Sample records for ems program conforms
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Sandia National Laboratories, California Environmental Management System program manual.
DOE Office of Scientific and Technical Information (OSTI.GOV)
Larsen, Barbara L.
2012-03-01
The Sandia National Laboratories, California (SNL/CA) Environmental Management System (EMS) Program Manual documents the elements of the site EMS Program. The SNL/CA EMS Program conforms to the International Standard on Environmental Management Systems, ISO 14001:2004and Department of Energy (DOE) Order 436.1. Sandia National Laboratories, California (SNL/CA) has maintained functional environmental programs to assist with regulatory compliance for more than 30 years. During 2005, these existing programs were rolled into a formal environmental management system (EMS) that expands beyond the traditional compliance focus to managing and improving environmental performance and stewardship practices for all site activities. An EMS is a setmore » of inter-related elements that represent a continuing cycle of planning, implementing, evaluating, and improving processes and actions undertaken to achieve environmental policy and goals. The SNL/CA EMS Program conforms to the International Standard for Environmental Management Systems, ISO 14001:2004 (ISO 2004). The site first received ISO 14001 certification in September 2006 and recertification in 2009. SNL/CA's EMS Program is applicable to the Sandia, Livermore site only. Although SNL/CA operates as one organizational division of the overall Sandia National Laboratories, the EMS Program is site-specific, with site-specific objectives and targets. SNL/CA (Division 8000) benefits from the organizational structure as it provides corporate level policies, procedures, and standards, and established processes that connect to and support elements of the SNL/CA EMS Program. Additionally, SNL/CA's EMS Program benefits from two corporate functional programs (Facilities Energy and Water Resource Management and Fleet Services programs) that maintain responsibility for energy management and fleet services for all Sandia locations. Each EMS element is further enhanced with site-specific processes and standards. Division 8000 has several groups operating at Sandia National Laboratories, New Mexico (SNL/NM). Although these groups, from an organizational perspective, are part of Division 8000, they are managed locally and fall under the environmental requirements specific to their New Mexico location. The New Mexico groups in Division 8000 follow the corporate EMS Program for New Mexico operations.« less
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- CONUS Double Resolution (Lambert Conformal - 40km) NEMS Non-hydrostatic Multiscale Model on the B grid AWIPS grid 212 Regional - CONUS Double Resolution (Lambert Conformal - 40km) NEMS Non-hydrostatic 132 - Double Resolution (Lambert Conformal - 16km) NEMS Non-hydrostatic Multiscale Model on the B grid
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A Descriptive Analysis of the Use of Twitter by Emergency Medicine Residency Programs.
Diller, David; Yarris, Lalena M
2018-02-01
Twitter is increasingly recognized as an instructional tool by the emergency medicine (EM) community. In 2012, the Council of Residency Directors in Emergency Medicine (CORD) recommended that EM residency programs' Twitter accounts be managed solely by faculty. To date, little has been published regarding the patterns of Twitter use by EM residency programs. We analyzed current patterns in Twitter use among EM residency programs with accounts and assessed conformance with CORD recommendations. In this mixed methods study, a 6-question, anonymous survey was distributed via e-mail using SurveyMonkey. In addition, a Twitter-based search was conducted, and the public profiles of EM residency programs' Twitter accounts were analyzed. We calculated descriptive statistics and performed a qualitative analysis on the data. Of 168 Accreditation Council for Graduate Medical Education-accredited EM programs, 88 programs (52%) responded. Of those programs, 58% (51 of 88) reported having a program-level Twitter account. Residents served as content managers for those accounts in the majority of survey respondents (61%, 28 of 46). Most programs did not publicly disclose the identity or position of their Twitter content manager. We found a wide variety of applications for Twitter, with EM programs most frequently using Twitter for educational and promotional purposes. There is significant variability in the numbers of followers for EM programs' Twitter accounts. Applications and usage among EM residency programs are varied, and are frequently not consistent with current CORD recommendations.
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Structure and conformational dynamics of scaffolded DNA origami nanoparticles
2017-05-08
all-atom molecular dynamics and coarse-grained finite element modeling to DX-based nanoparticles to elucidate their fine-scale and global conforma... finite element (FE) modeling approach CanDo is also routinely used to predict the 3D equilibrium conformation of programmed DNA assemblies based on a...model with both experimental cryo-electron microscopy (cryo-EM) data and all-atom modeling. MATERIALS AND METHODS Lattice-free finite element model
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Matsumoto, Atsushi; Miyazaki, Naoyuki; Takagi, Junichi; Iwasaki, Kenji
2017-03-23
In this study, we develop an approach termed "2D hybrid analysis" for building atomic models by image matching from electron microscopy (EM) images of biological molecules. The key advantage is that it is applicable to flexible molecules, which are difficult to analyze by 3DEM approach. In the proposed approach, first, a lot of atomic models with different conformations are built by computer simulation. Then, simulated EM images are built from each atomic model. Finally, they are compared with the experimental EM image. Two kinds of models are used as simulated EM images: the negative stain model and the simple projection model. Although the former is more realistic, the latter is adopted to perform faster computations. The use of the negative stain model enables decomposition of the averaged EM images into multiple projection images, each of which originated from a different conformation or orientation. We apply this approach to the EM images of integrin to obtain the distribution of the conformations, from which the pathway of the conformational change of the protein is deduced.
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Conformal Electromagnetic Particle in Cell: A Review
Meierbachtol, Collin S.; Greenwood, Andrew D.; Verboncoeur, John P.; ...
2015-10-26
We review conformal (or body-fitted) electromagnetic particle-in-cell (EM-PIC) numerical solution schemes. Included is a chronological history of relevant particle physics algorithms often employed in these conformal simulations. We also provide brief mathematical descriptions of particle-tracking algorithms and current weighting schemes, along with a brief summary of major time-dependent electromagnetic solution methods. Several research areas are also highlighted for recommended future development of new conformal EM-PIC methods.
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Sanchez Sorzano, Carlos Oscar; Alvarez-Cabrera, Ana Lucia; Kazemi, Mohsen; Carazo, Jose María; Jonić, Slavica
2016-04-26
Single-particle electron microscopy (EM) has been shown to be very powerful for studying structures and associated conformational changes of macromolecular complexes. In the context of analyzing conformational changes of complexes, distinct EM density maps obtained by image analysis and three-dimensional (3D) reconstruction are usually analyzed in 3D for interpretation of structural differences. However, graphic visualization of these differences based on a quantitative analysis of elastic transformations (deformations) among density maps has not been done yet due to a lack of appropriate methods. Here, we present an approach that allows such visualization. This approach is based on statistical analysis of distances among elastically aligned pairs of EM maps (one map is deformed to fit the other map), and results in visualizing EM maps as points in a lower-dimensional distance space. The distances among points in the new space can be analyzed in terms of clusters or trajectories of points related to potential conformational changes. The results of the method are shown with synthetic and experimental EM maps at different resolutions. Copyright © 2016 Biophysical Society. Published by Elsevier Inc. All rights reserved.
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Inmetro acts in the accreditation of Conformity Assessment Bodies - CAB. Acreditação de Laboratórios Acreditação de Organismos de Certificação Acreditação de Organismos de Inspeção See the lectures
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Department of Natural Resources logo, color scheme Alaska Department of Natural Resources Recorder's Office two pages. ** At the time of recording, a conformed copy is $2.00 - Any copy made after that time will
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Vector Galileon and inflationary magnetogenesis
NASA Astrophysics Data System (ADS)
Nandi, Debottam; Shankaranarayanan, S.
2018-01-01
Cosmological inflation provides the initial conditions for the structure formation. However, the origin of large-scale magnetic fields can not be addressed in this framework. The key issue for this long-standing problem is the conformal invariance of the electromagnetic (EM) field in 4-D. While many approaches have been proposed in the literature for breaking conformal invariance of the EM action, here, we provide a completely new way of looking at the modifications to the EM action and generation of primordial magnetic fields during inflation. We explicitly construct a higher derivative EM action that breaks conformal invariance by demanding three conditions—theory be described by vector potential Aμ and its derivatives, Gauge invariance be satisfied, and equations of motion be linear in second derivatives of vector potential. The unique feature of our model is that appreciable magnetic fields are generated at small wavelengths while tiny magnetic fields are generated at large wavelengths that are consistent with current observations.
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Shao, Xuan; Gao, Yanfeng; Zhu, Chuanjun; Liu, Xuehui; Yao, Jinlong; Cui, Yuxin; Wang, Rui
2007-05-15
We investigated a series of conformations of endomorphin-2 (EM-2) analogs substituted by phenylglycine (Phg) and homophenylalanine (Hfe) in the position 3 or 4 by two-dimensional (1)H NMR spectroscopy and molecular modeling. Evaluating the aromatic interactions and the dihedral angles in these phenylalanine mimics, we have observed that the conformations in trans isomer have varied from extended to folded as bioactivity decreases. It is suggested that the flexibility of aromatic side chain affects the backbone of EM-2 to adopt folded structures, which may block the ligands in binding to micro-opioid receptor.
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Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy
Yeung, Heidi O.; Förster, Andreas; Bebeacua, Cecilia; Niwa, Hajime; Ewens, Caroline; McKeown, Ciarán; Zhang, Xiaodong; Freemont, Paul S.
2014-01-01
The type II AAA+ protein p97 is involved in numerous cellular activities, including endoplasmic reticulum-associated degradation, transcription activation, membrane fusion and cell-cycle control. These activities are at least in part regulated by the ubiquitin system, in which p97 is thought to target ubiquitylated protein substrates within macromolecular complexes and assist in their extraction or disassembly. Although ATPase activity is essential for p97 function, little is known about how ATP binding or hydrolysis is coupled with p97 conformational changes and substrate remodelling. Here, we have used single-particle electron cryomicroscopy (cryo-EM) to study the effect of nucleotides on p97 conformation. We have identified conformational heterogeneity within the cryo-EM datasets from which we have resolved two major p97 conformations. A comparison of conformations reveals inter-ring rotations upon nucleotide binding and hydrolysis that may be linked to the remodelling of target protein complexes. PMID:24598262
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Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study.
Huang, Rui; Ripstein, Zev A; Augustyniak, Rafal; Lazniewski, Michal; Ginalski, Krzysztof; Kay, Lewis E; Rubinstein, John L
2016-07-19
The AAA+ (ATPases associated with a variety of cellular activities) enzymes play critical roles in a variety of homeostatic processes in all kingdoms of life. Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), the archaeal homolog of the ubiquitous AAA+ protein Cdc48/p97, functions in concert with the 20S proteasome by unfolding substrates and passing them on for degradation. Here, we present electron cryomicroscopy (cryo-EM) maps showing that VAT undergoes large conformational rearrangements during its ATP hydrolysis cycle that differ dramatically from the conformational states observed for Cdc48/p97. We validate key features of the model with biochemical and solution methyl-transverse relaxation optimized spectroscopY (TROSY) NMR experiments and suggest a mechanism for coupling the energy of nucleotide hydrolysis to substrate unfolding. These findings illustrate the unique complementarity between cryo-EM and solution NMR for studies of molecular machines, showing that the structural properties of VAT, as well as the population distributions of conformers, are similar in the frozen specimens used for cryo-EM and in the solution phase where NMR spectra are recorded.
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Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study
Huang, Rui; Ripstein, Zev A.; Augustyniak, Rafal; Lazniewski, Michal; Ginalski, Krzysztof; Kay, Lewis E.; Rubinstein, John L.
2016-01-01
The AAA+ (ATPases associated with a variety of cellular activities) enzymes play critical roles in a variety of homeostatic processes in all kingdoms of life. Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), the archaeal homolog of the ubiquitous AAA+ protein Cdc48/p97, functions in concert with the 20S proteasome by unfolding substrates and passing them on for degradation. Here, we present electron cryomicroscopy (cryo-EM) maps showing that VAT undergoes large conformational rearrangements during its ATP hydrolysis cycle that differ dramatically from the conformational states observed for Cdc48/p97. We validate key features of the model with biochemical and solution methyl-transverse relaxation optimized spectroscopY (TROSY) NMR experiments and suggest a mechanism for coupling the energy of nucleotide hydrolysis to substrate unfolding. These findings illustrate the unique complementarity between cryo-EM and solution NMR for studies of molecular machines, showing that the structural properties of VAT, as well as the population distributions of conformers, are similar in the frozen specimens used for cryo-EM and in the solution phase where NMR spectra are recorded. PMID:27402735
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Structural dynamics of ribosome subunit association studied by mixing-spraying time-resolved cryo-EM
Chen, Bo; Kaledhonkar, Sandip; Sun, Ming; Shen, Bingxin; Lu, Zonghuan; Barnard, David; Lu, Toh-Ming; Gonzalez, Ruben L.; Frank, Joachim
2015-01-01
Ribosomal subunit association is a key checkpoint in translation initiation, but its structural dynamics are poorly understood. Here, we used a recently developed mixing-spraying, time-resolved, cryogenic electron microscopy (cryo-EM) method to study ribosomal subunit association in the sub-second time range. We have improved this method and increased the cryo-EM data yield by tenfold. Pre-equilibrium states of the association reaction were captured by reacting the mixture of ribosomal subunits for 60 ms and 140 ms. We also identified three distinct ribosome conformations in the associated ribosomes. The observed proportions of these conformations are the same in these two time points, suggesting that ribosomes equilibrate among the three conformations within less than 60 ms upon formation. Our results demonstrate that the mixing-spraying method can capture multiple states of macromolecules during a sub-second reaction. Other fast processes, such as translation initiation, decoding and ribosome recycling, are amenable to study with this method. PMID:26004440
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Combining theoretical and experimental data to decipher CFTR 3D structures and functions.
Hoffmann, Brice; Elbahnsi, Ahmad; Lehn, Pierre; Décout, Jean-Luc; Pietrucci, Fabio; Mornon, Jean-Paul; Callebaut, Isabelle
2018-05-19
Cryo-electron microscopy (cryo-EM) has recently provided invaluable experimental data about the full-length cystic fibrosis transmembrane conductance regulator (CFTR) 3D structure. However, this experimental information deals with inactive states of the channel, either in an apo, quiescent conformation, in which nucleotide-binding domains (NBDs) are widely separated or in an ATP-bound, yet closed conformation. Here, we show that 3D structure models of the open and closed forms of the channel, now further supported by metadynamics simulations and by comparison with the cryo-EM data, could be used to gain some insights into critical features of the conformational transition toward active CFTR forms. These critical elements lie within membrane-spanning domains but also within NBD1 and the N-terminal extension, in which conformational plasticity is predicted to occur to help the interaction with filamin, one of the CFTR cellular partners.
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Communication: Origin of the contributions to DNA structure in phages
Myers, Christopher G.; Pettitt, B. Montgomery
2013-01-01
Cryo electron microscopy (cryo-EM) data of the interior of phages show ordering of the interior DNA that has been interpreted as a nearly perfectly ordered polymer. We show surface-induced correlations, excluded volume, and electrostatic forces are sufficient to predict most of the major features of the current structural data for DNA packaged within viral capsids without additional ordering due to elastic bending forces for the polymer. Current models assume highly-ordered, even spooled, hexagonally packed conformations based on interpretation of cryo-EM density maps. We show herein that the surface induced packing of short (6mer), unconnected DNA polymer segments is the only necessary ingredient in creating ringed densities consistent with experimental density maps. This implies the ensemble of possible conformations of polymeric DNA within the capsid that are consistent with cryo-EM data may be much larger than implied by traditional interpretations where such rings can only result from highly-ordered spool-like conformations. This opens the possibility of a more disordered, entropically-driven view of phage packaging thermodynamics. We also show the electrostatics of the DNA contributes a large portion of the internal hydrostatic and osmotic pressures of a phage virion, suggesting that nonlinear elastic anomalies might reduce the overall elastic bending enthalpy of more disordered conformations to have allowable free energies. PMID:23444988
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Communication: Origin of the contributions to DNA structure in phages.
Myers, Christopher G; Pettitt, B Montgomery
2013-02-21
Cryo electron microscopy (cryo-EM) data of the interior of phages show ordering of the interior DNA that has been interpreted as a nearly perfectly ordered polymer. We show surface-induced correlations, excluded volume, and electrostatic forces are sufficient to predict most of the major features of the current structural data for DNA packaged within viral capsids without additional ordering due to elastic bending forces for the polymer. Current models assume highly-ordered, even spooled, hexagonally packed conformations based on interpretation of cryo-EM density maps. We show herein that the surface induced packing of short (6mer), unconnected DNA polymer segments is the only necessary ingredient in creating ringed densities consistent with experimental density maps. This implies the ensemble of possible conformations of polymeric DNA within the capsid that are consistent with cryo-EM data may be much larger than implied by traditional interpretations where such rings can only result from highly-ordered spool-like conformations. This opens the possibility of a more disordered, entropically-driven view of phage packaging thermodynamics. We also show the electrostatics of the DNA contributes a large portion of the internal hydrostatic and osmotic pressures of a phage virion, suggesting that nonlinear elastic anomalies might reduce the overall elastic bending enthalpy of more disordered conformations to have allowable free energies.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Lin, Yen-Chen; Naveen, Vankadari; Molecular Cell Biology, Taiwan International Graduate Program, Institute of Molecular Biology, Academia Sinica, and Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
During DNA replication, bacterial helicase is recruited as a complex in association with loader proteins to unwind the parental duplex. Previous structural studies have reported saturated 6:6 helicase-loader complexes with different conformations. However, structural information on the sub-stoichiometric conformations of these previously-documented helicase-loader complexes remains elusive. Here, with the aid of single particle electron-microscopy (EM) image reconstruction, we present the Geobacillus kaustophilus HTA426 helicase-loader (DnaC-DnaI) complex with a 6:2 binding stoichiometry in the presence of ATPγS. In the 19 Å resolution EM map, the undistorted and unopened helicase ring holds a robust loader density above the C-terminal RecA-like domain. Meanwhile, themore » path of the central DNA binding channel appears to be obstructed by the reconstructed loader density, implying its potential role as a checkpoint conformation to prevent the loading of immature complex onto DNA. Our data also reveals that the bound nucleotides and the consequently induced conformational changes in the helicase hexamer are essential for active association with loader proteins. These observations provide fundamental insights into the formation of the helicase-loader complex in bacteria that regulates the DNA replication process. - Highlights: • Helicase-loader complex structure with 6:2 sub-stoichiometry is resolved by EM. • Helicase hexamer in 6:2 sub-stoichiometry is constricted and un-opened. • 6:2 binding ratio of helicase-loader complex could act as a DNA loading checkpoint. • Nucleotides stabilize helicase-loader complex at low protein concentrations.« less
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ACHP GUIDANCE ON PROGRAM COMMENTS AS A PROGRAM ALTERNATIVE
the benefits of the program comment process? Are program comments appropriate for all classes of undertakings or agency programs? Who can make requests for program comments? Does my agency need to justify the agency's responsibility in the program comment process? What is the ACHP's responsibility in the program
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Fitting Multimeric Protein Complexes into Electron Microscopy Maps Using 3D Zernike Descriptors
Esquivel-Rodríguez, Juan; Kihara, Daisuke
2012-01-01
A novel computational method for fitting high-resolution structures of multiple proteins into a cryoelectron microscopy map is presented. The method named EMLZerD generates a pool of candidate multiple protein docking conformations of component proteins, which are later compared with a provided electron microscopy (EM) density map to select the ones that fit well into the EM map. The comparison of docking conformations and the EM map is performed using the 3D Zernike descriptor (3DZD), a mathematical series expansion of three-dimensional functions. The 3DZD provides a unified representation of the surface shape of multimeric protein complex models and EM maps, which allows a convenient, fast quantitative comparison of the three dimensional structural data. Out of 19 multimeric complexes tested, near native complex structures with a root mean square deviation of less than 2.5 Å were obtained for 14 cases while medium range resolution structures with correct topology were computed for the additional 5 cases. PMID:22417139
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Fitting multimeric protein complexes into electron microscopy maps using 3D Zernike descriptors.
Esquivel-Rodríguez, Juan; Kihara, Daisuke
2012-06-14
A novel computational method for fitting high-resolution structures of multiple proteins into a cryoelectron microscopy map is presented. The method named EMLZerD generates a pool of candidate multiple protein docking conformations of component proteins, which are later compared with a provided electron microscopy (EM) density map to select the ones that fit well into the EM map. The comparison of docking conformations and the EM map is performed using the 3D Zernike descriptor (3DZD), a mathematical series expansion of three-dimensional functions. The 3DZD provides a unified representation of the surface shape of multimeric protein complex models and EM maps, which allows a convenient, fast quantitative comparison of the three-dimensional structural data. Out of 19 multimeric complexes tested, near native complex structures with a root-mean-square deviation of less than 2.5 Å were obtained for 14 cases while medium range resolution structures with correct topology were computed for the additional 5 cases.
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X-rays in the Cryo-EM Era: Structural Biology’s Dynamic Future
Shoemaker, Susannah C.; Ando, Nozomi
2018-01-01
Over the past several years, single-particle cryo-electron microscopy (cryo-EM) has emerged as a leading method for elucidating macromolecular structures at near-atomic resolution, rivaling even the established technique of X-ray crystallography. Cryo-EM is now able to probe proteins as small as hemoglobin (64 kDa), while avoiding the crystallization bottleneck entirely. The remarkable success of cryo-EM has called into question the continuing relevance of X-ray methods, particularly crystallography. To say that the future of structural biology is either cryo-EM or crystallography, however, would be misguided. Crystallography remains better suited to yield precise atomic coordinates of macromolecules under a few hundred kDa in size, while the ability to probe larger, potentially more disordered assemblies is a distinct advantage of cryo-EM. Likewise, crystallography is better equipped to provide high-resolution dynamic information as a function of time, temperature, pressure, and other perturbations, whereas cryo-EM offers increasing insight into conformational and energy landscapes, particularly as algorithms to deconvolute conformational heterogeneity become more advanced. Ultimately, the future of both techniques depends on how their individual strengths are utilized to tackle questions on the frontiers of structural biology. Structure determination is just one piece of a much larger puzzle: a central challenge of modern structural biology is to relate structural information to biological function. In this perspective, we share insight from several leaders in the field and examine the unique and complementary ways in which X-ray methods and cryo-EM can shape the future of structural biology. PMID:29227642
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Directly Reconstructing Principal Components of Heterogeneous Particles from Cryo-EM Images
Tagare, Hemant D.; Kucukelbir, Alp; Sigworth, Fred J.; Wang, Hongwei; Rao, Murali
2015-01-01
Structural heterogeneity of particles can be investigated by their three-dimensional principal components. This paper addresses the question of whether, and with what algorithm, the three-dimensional principal components can be directly recovered from cryo-EM images. The first part of the paper extends the Fourier slice theorem to covariance functions showing that the three-dimensional covariance, and hence the principal components, of a heterogeneous particle can indeed be recovered from two-dimensional cryo-EM images. The second part of the paper proposes a practical algorithm for reconstructing the principal components directly from cryo-EM images without the intermediate step of calculating covariances. This algorithm is based on maximizing the (posterior) likelihood using the Expectation-Maximization algorithm. The last part of the paper applies this algorithm to simulated data and to two real cryo-EM data sets: a data set of the 70S ribosome with and without Elongation Factor-G (EF-G), and a data set of the inluenza virus RNA dependent RNA Polymerase (RdRP). The first principal component of the 70S ribosome data set reveals the expected conformational changes of the ribosome as the EF-G binds and unbinds. The first principal component of the RdRP data set reveals a conformational change in the two dimers of the RdRP. PMID:26049077
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Damped-Dynamics Flexible Fitting
Kovacs, Julio A.; Yeager, Mark; Abagyan, Ruben
2008-01-01
In fitting atomic structures into EM maps, it often happens that the map corresponds to a different conformation of the structure. We have developed a new methodology to handle these situations that preserves the covalent geometry of the structure and allows the modeling of large deformations. The first goal is achieved by working in generalized coordinates (positional and internal coordinates), and the second by avoiding harmonic potentials. Instead, we use dampers (shock absorbers) between every pair of atoms, combined with a force field that attracts the atomic structure toward incompletely occupied regions of the EM map. The trajectory obtained by integrating the resulting equations of motion converges to a conformation that, in our validation cases, was very close to the target atomic structure. Compared to current methods, our approach is more efficient and robust against wrong solutions and to overfitting, and does not require user intervention or subjective decisions. Applications to the computation of transition pathways between known conformers, homology and loop modeling, as well as protein docking, are also discussed. PMID:18586844
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Damped-dynamics flexible fitting.
Kovacs, Julio A; Yeager, Mark; Abagyan, Ruben
2008-10-01
In fitting atomic structures into EM maps, it often happens that the map corresponds to a different conformation of the structure. We have developed a new methodology to handle these situations that preserves the covalent geometry of the structure and allows the modeling of large deformations. The first goal is achieved by working in generalized coordinates (positional and internal coordinates), and the second by avoiding harmonic potentials. Instead, we use dampers (shock absorbers) between every pair of atoms, combined with a force field that attracts the atomic structure toward incompletely occupied regions of the EM map. The trajectory obtained by integrating the resulting equations of motion converges to a conformation that, in our validation cases, was very close to the target atomic structure. Compared to current methods, our approach is more efficient and robust against wrong solutions and to overfitting, and does not require user intervention or subjective decisions. Applications to the computation of transition pathways between known conformers, homology and loop modeling, as well as protein docking, are also discussed.
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Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy.
Fischer, Niels; Konevega, Andrey L; Wintermeyer, Wolfgang; Rodnina, Marina V; Stark, Holger
2010-07-15
The translocation step of protein synthesis entails large-scale rearrangements of the ribosome-transfer RNA (tRNA) complex. Here we have followed tRNA movement through the ribosome during translocation by time-resolved single-particle electron cryomicroscopy (cryo-EM). Unbiased computational sorting of cryo-EM images yielded 50 distinct three-dimensional reconstructions, showing the tRNAs in classical, hybrid and various novel intermediate states that provide trajectories and kinetic information about tRNA movement through the ribosome. The structures indicate how tRNA movement is coupled with global and local conformational changes of the ribosome, in particular of the head and body of the small ribosomal subunit, and show that dynamic interactions between tRNAs and ribosomal residues confine the path of the tRNAs through the ribosome. The temperature dependence of ribosome dynamics reveals a surprisingly flat energy landscape of conformational variations at physiological temperature. The ribosome functions as a Brownian machine that couples spontaneous conformational changes driven by thermal energy to directed movement.
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University of Maryland MRSEC - Education
Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher : Championing Service-based Education Outreach Since 1996 Program Areas Pre-college Programs Project Lead the , and post-docs effective skills in education outreach at the pre-college level. The UMD-MRSEC uses a
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Reducing Energy Burden with Solar: Colorado's Strategy and a Roadmap for
purchasing other necessities. In some circumstances, solar photovoltaics (PV) can reduce this energy burden -income community solar demonstration projects Incorporating PV into its weatherization program Promoting utility investment in low-income PV programs. In 2015, CEO launched its low-income community solar program
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Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher Programs Community Outreach Educational Resources News MRSEC Featured MRSEC Calendar Employment contents without alteration is granted to educational institutions for non-profit administrative or
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Science Programs Applied Energy Programs Civilian Nuclear Energy Programs Laboratory Directed Research Service Academies Research Associates (SARA) Postdocs, Students Employee, Retiree Resources Benefits New
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strategic scenario planning and analysis Program portfolio analysis Program management, planning and strategic execution Change management and operational improvement Research Interests Bioenergy supply chains management, organizational improvement, and program and project management. Prior Work Experience Consultant
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Science Programs Applied Energy Programs Civilian Nuclear Energy Programs Laboratory Directed Research Service Academies Research Associates (SARA) Postdocs, Students Employee, Retiree Resources Benefits New
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Science Programs Applied Energy Programs Civilian Nuclear Energy Programs Laboratory Directed Research Service Academies Research Associates (SARA) Postdocs, Students Employee, Retiree Resources Benefits New
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Ocean Drilling Program: Public Information: News
site ODP's main web site ODP/TAMU Science Operator Home Ocean Drilling Program News The Ocean Drilling Program was succeeded in 2003 by the Integrated Ocean Drilling Program (IODP). The IODP U.S. Implementing
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Science Programs Applied Energy Programs Civilian Nuclear Energy Programs Laboratory Directed Research Service Academies Research Associates (SARA) Postdocs, Students Employee, Retiree Resources Benefits New
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Computational prediction of atomic structures of helical membrane proteins aided by EM maps.
Kovacs, Julio A; Yeager, Mark; Abagyan, Ruben
2007-09-15
Integral membrane proteins pose a major challenge for protein-structure prediction because only approximately 100 high-resolution structures are available currently, thereby impeding the development of rules or empirical potentials to predict the packing of transmembrane alpha-helices. However, when an intermediate-resolution electron microscopy (EM) map is available, it can be used to provide restraints which, in combination with a suitable computational protocol, make structure prediction feasible. In this work we present such a protocol, which proceeds in three stages: 1), generation of an ensemble of alpha-helices by flexible fitting into each of the density rods in the low-resolution EM map, spanning a range of rotational angles around the main helical axes and translational shifts along the density rods; 2), fast optimization of side chains and scoring of the resulting conformations; and 3), refinement of the lowest-scoring conformations with internal coordinate mechanics, by optimizing the van der Waals, electrostatics, hydrogen bonding, torsional, and solvation energy contributions. In addition, our method implements a penalty term through a so-called tethering map, derived from the EM map, which restrains the positions of the alpha-helices. The protocol was validated on three test cases: GpA, KcsA, and MscL.
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NBIC: Ballast Water Reporting Forms
for the Coast Guard's Equivalent Reporting Program (ERP). The ERP program is restricted to NON regulations, submit a BWMR at least 24 hours before the vessel arrives in Montreal, Quebec. Non-US/non | FAQ| Equivalent Reporting Program Privacy policy - Terms of Use - Contact us: nbic@ballastreport.org
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Office of Water Programs | Water Research Program | University of Wyoming
to UW Global Navigation Admissions UW Admissions First Year Transfer International Graduate Cost of Plans Graduate Education Honors Program Majors/Degrees UW at a Distance Art Museum UW Libraries Ctr UW Life Campus Safety Campus Maps Transit & Parking Res Life & Dining Diversity Student
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Tier 3 Vehicle and Gasoline Sulfur Program The Tier 3 Vehicle and Gasoline Sulfur Program requires run on gasoline, diesel, or alternative fuels. Additionally, this program requires gasoline refiners and importers to reduce the sulfur content of gasoline sold in the United States. For more information
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Intern Programs | College and University Faculty
application process, please feel free to get in touch with the program contacts. Letters of Recommendation If applicant in the following areas: Academic achievement Academic potential Capability for working Teng PARTI SIST SULI VFP Program Requirements CCI IPM Lee Teng PARTI SULI IPM VFP The Fermilab
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University of Maryland MRSEC - Research: Highlights
; National Labs International Educational Education Pre-College Programs Homeschool Programs Undergraduate Perspective at UMD MRSEC Nanoscience Camp Annual Middle School Student Science Conference (SSC) Pre ) Activities UMD-MRSEC Research Experience for Undergraduates Program (REU) Pre-Engineering Program
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Environmental Protection: Controlling the Present
Science Programs Applied Energy Programs Civilian Nuclear Energy Programs Laboratory Directed Research Service Academies Research Associates (SARA) Postdocs, Students Employee, Retiree Resources Benefits New
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Technology to Market subprogram. Sue focuses on effective management, planning, milestone tracking, reporting Market programs, the Federal Energy Management Program Office, and the Office of Strategic Programs administration, planning and financial analysis. Education Human Resources Management, Employee Relations and
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Verification of Employment (VOE)
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IARC - Illinois Accelerator Research Center | Pilot Program
Toggle navigation Pilot Program Agenda Directions Registration Illinois Accelerator Research Center National Laboratory present Accelerator Stewardship Test Facility Pilot Program Use accelerator technology , energy and environment. With this pilot program, the DOE Office of Science National Laboratories are
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Pollution Prevention Grants Program The Pollution Prevention (P2) Grants Program supports state and tribal technical assistance, education, and research programs that help businesses and industries
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications â¹âº You are here CTIO Home » Outreach » Tourism » Tourism in Chile Tourism in Chile Map of
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications â¹âº You are here CTIO Home » Outreach » Tourism » Astro Tourism in Chile Astro Tourism in
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Coastal Warning Display Program
! Boating Safety Beach Hazards Rip Currents Hypothermia Hurricanes Thunderstorms Lightning Coastal Flooding Tsunamis 406 EPIRB's National Weather Service Marine Forecasts COASTAL WARNING DISPLAY PROGRAM Marine COASTAL WARNING DISPLAY PROGRAM As of February 15, 1989, the National Weather Service retired its Coastal
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PMC's Florida Bay & Adjacent Marine Systems Science Program
Florida Bay and Adjacent Marine Systems Science Program Inverted image, click link below to view actual image and caption click to display actual image and caption Program Overview Management & - January 2002 >For more, click here to view the What's New Page... | Main | Overview | Management &
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Alternative Fuels Data Center: City of Chicago Program Encourages Petroleum
Displacement and Collaboration Between Departments City of Chicago Program Encourages Petroleum : City of Chicago Program Encourages Petroleum Displacement and Collaboration Between Departments on Facebook Tweet about Alternative Fuels Data Center: City of Chicago Program Encourages Petroleum
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Employment Opportunities | CTIO
Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Natural Gas and Propane Vehicle Grant Program The Tennessee Department of Environment and Conservation's Office of Energy Programs administers the Natural Gas and Propane Vehicle Grant Program (Program and must intend to operate vehicles in Tennessee for a minimum of six years. Grant applications are
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University of Maryland MRSEC - Education: College
; (we call this type of surface a vicinal surface). Modern scanned-probe microscopes, such as the STM Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher MRSEC Templates Opportunities Search Home » Education » Undergraduate/Graduate Programs Undergraduate
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Other Student Opportunities | CTIO
Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Observing at NOAO South | CTIO
Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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EPO/CADIAS Calendar Activities | CTIO
Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Excited State Processes in Electronic and Bio Nanomaterials (ESP-2016)
Science Programs Applied Energy Programs Civilian Nuclear Energy Programs Laboratory Directed Research Service Academies Research Associates (SARA) Postdocs, Students Employee, Retiree Resources Benefits New
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications â¹âº You are here CTIO Home » Outreach » Tololo and Tourism Tololo and Tourism Visits to Cerro
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Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications , and books, most of which can be found at CTIO's La Serena library branch. Electronic Resources Access
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Health and Environmental Research [OHER], the program that supported most Biology in the Department. The origins of DOE's biology program traced to the Manhattan Project, the World War II program that produced Technical Report; 1964 Impact of Radiation Biology on Fundamental Insights in Biology; DOE Technical Report
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Directly reconstructing principal components of heterogeneous particles from cryo-EM images.
Tagare, Hemant D; Kucukelbir, Alp; Sigworth, Fred J; Wang, Hongwei; Rao, Murali
2015-08-01
Structural heterogeneity of particles can be investigated by their three-dimensional principal components. This paper addresses the question of whether, and with what algorithm, the three-dimensional principal components can be directly recovered from cryo-EM images. The first part of the paper extends the Fourier slice theorem to covariance functions showing that the three-dimensional covariance, and hence the principal components, of a heterogeneous particle can indeed be recovered from two-dimensional cryo-EM images. The second part of the paper proposes a practical algorithm for reconstructing the principal components directly from cryo-EM images without the intermediate step of calculating covariances. This algorithm is based on maximizing the posterior likelihood using the Expectation-Maximization algorithm. The last part of the paper applies this algorithm to simulated data and to two real cryo-EM data sets: a data set of the 70S ribosome with and without Elongation Factor-G (EF-G), and a data set of the influenza virus RNA dependent RNA Polymerase (RdRP). The first principal component of the 70S ribosome data set reveals the expected conformational changes of the ribosome as the EF-G binds and unbinds. The first principal component of the RdRP data set reveals a conformational change in the two dimers of the RdRP. Copyright © 2015 Elsevier Inc. All rights reserved.
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ACHP GUIDANCE ON PROGRAM COMMENTS AS A PROGRAM ALTERNATIVE
usual case-by-case basis. Format of this Guidance The following table identifies the steps in the adequate monitoring of issued program comments. Following the table, the ACHP has developed a series of following subject line: "RE: ACHP Program Comment Guidance." Return to Top
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Telescopes on Cerro Tololo & Cerro Pachon | CTIO
Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Victor Blanco 4-m Telescope | CTIO
Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications
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Research Library Science Briefs Science News Science Highlights Lab Organizations Science Programs Applied Innovation Research Capabilities Deploying Innovation Technology Opportunities Innovation in New Mexico Los Laboratory Delivering science and technology to protect our nation and promote world stability Science &
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NOAA Office of Exploration and Research > Science > Overview
2014 Funding Opportunities Contact Us Program Review Review Panel Final Report Review Team Documents Opportunities Contact Us Program Review Review Panel Final Report Review Team Documents Presentations Supporting
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Defense Threat Reduction Agency > Careers > Onboarding > Before You Report
Development Work/Life Programs Onboarding Onboarding Overview Before You Report Sponsor Program Getting Here , you may be eligible to enroll in health, dental and vision, life insurance, and flexible spending and Mass Transit Benefit Program. Health/Dental/Vision/Life for Civilian Employees Health/Dental/Life
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ACHP | Working Together to Build a More Inclusive Preservation Program
Dennis Arguelles, Los Angeles Program Manager, National Parks Conservation Association; Former Director of Programs for Search To Involve Pilipino Americans Dennis G. Arguelles is currently the Los Angeles Filipinotown community of Los Angeles and Filipino Americans throughout Los Angeles County. He is the former
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The Robotic Hugo E. Schwarz Telescope | CTIO
Program PIA Program GO-FAAR Program Other Opportunities Tourism Visits to Tololo Astro tourism in Chile Tourism in Chile Information for travelers Visit Tololo Media Relations News Press Release Publications of a new electronic drive system for the mount, and the second, dedicate to re-design the dome
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Idaho | Midmarket Solar Policies in the United States | Solar Research |
to develop a 500 kW community solar project. State Incentive Programs Program Administrator Incentive and incentive programs. Net metering and interconnection Idaho Power: Net Metering and Interconnection
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DoD Yellow Ribbon Program For Reintegration
their families get the support and care they need. VIDEO Video Link Yellow Ribbon Program Eases Post Reintegration Program will help them resolve Velazquez' No. 1 post-deployment challenge: finding a civilian job reintegration event regarding post-traumatic stress: "I need your help." Story Program Fills Gap for
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Defense Threat Reduction Agency > Careers > Onboarding > Special Programs
, programs, and practices to help our employees and Service members balance work and family responsibilities . We have put in place family-friendly Work/Life programs and policies designed to create a more Children and Family Leave Programs Work/Life Resources Onboarding Home Onboarding Overview Before You
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Fermilab Friends for Science Education | Programs
Fermilab Friends for Science Education FFSE Home About Us Join Us Support Us Contact Us Programs and conducts programs to enhance the teaching and learning of science and mathematics at the inception in 1983, sponsored more than 30 programs; most of them are still offered today. FFSE supports the
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Fermilab Friends for Science Education | Programs | Past Donors
to support science education in this way. Here are their thoughts: I have attended many programs for teachers around the country. Sometimes just attending, sometimes presenting. Most programs were top down assessments WITH teachers, and trusted teachers to set up and run the programs. In other words, it was
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University of Maryland MRSEC - Site Map
; National Labs International Educational Education Pre-College Programs Homeschool Programs Undergraduate Education Outreach: Pre-college Programs Project Lead the Way Chemistry Programs Student Science Conference
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Defense.gov Special Report: MoDA: Ministry of Defense Advisors Program
range of international schools, the Foreign Service Institute, and a four day advisor training course alliances, new partnerships throughout the world by engaging in exercises, in training, in assistance and in . Several elements make the program unique: Extensive Training The MoDA program offers a comprehensive 7
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participants may invite up to two students (one of which may be a graduate student) to participate in hands-on touring the world class facilities at NREL. Program Requirements Participate in the one week summer program. Implement one lesson in the fall or spring. Local teachers receive a stipend of $250 for the one
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Government International, Research, and Nonprofit Organizations R&D Programs NREL is the only federal laboratory dedicated to the research, development, commercialization, and deployment of renewable energy and Program supports NREL research and development that focuses on biomass characterization, thermochemical
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Electrical and Computer Engineering |
PROGRAM GRADUATE PROGRAM RESEARCH FACULTY & STAFF MEET THE STUDENTS ALUMNI CORPORATE RELATIONS GIVING Gift FOLLOW US ON ECE SITE FEEDBACK 2012 Distinguished Alumni Award Recipients 2013 Distinguished Alumni Award Recipients 2014 Distinguished Alumni Award Recipients 2015 Distinguished Alumni Award
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reached out to elementary and high school students to expose them to earthquakes in a hands-on products laboratories publications nisee b.i.p. members education FAQs links education Education Program Internships K-12 Education Contact the PEER Education Program PEER's Educational Affiliates Student Design
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Environmental Epidemiology Program
accessible with JavaScript activated. Utah Department of Health Bureau of Epidemiology Environmental Epidemiology Program (EEP) The Environmental Epidemiology Program strives to improve the health of Utah residents through science-based environmental health policy and by empowering citizens with knowledge about
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History of the DOE Human Genome Program
History of the DOE Human Genome Program The following history is taken from the U.S. Department of Energy 1991-91 Human Genome Program Report (June 1992). This is an archived item. A brief history of the U.S. Department of Energy (DOE) Human Genome Program will be useful in a discussion of the objectives
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NREL Projects Awarded More Than $3 Million to Advance Novel Solar
in Grid Operations," evaluating a research solution to better integrate solar power generation funding program, which advances state-of-the-art techniques for predicting solar power generation to Office to advance predictive modeling of solar power as part of its Solar Forecasting 2 funding program
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Software Applications on the Peregrine System | High-Performance Computing
programming and optimization. Gaussian Chemistry Program for calculating molecular electronic structure and Materials Science Open-source classical molecular dynamics program designed for massively parallel systems framework Q-Chem Chemistry ab initio quantum chemistry package for predictin molecular structures
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University of Maryland MRSEC - Education: Professional Development for
"stepped" (we call this type of surface a vicinal surface). Modern scanned-probe microscopes International Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Facilities Logos MRSEC Templates Opportunities Search Home » Education » Teacher Programs Professional
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University of Maryland MRSEC - Research: Publications
; (we call this type of surface a vicinal surface). Modern scanned-probe microscopes, such as the STM Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher Publications Seed Publications Education Publications MRSEC III Publications (2005-Present) IRG 1 Publications
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University of Maryland MRSEC - News: Employment
. University of Maryland Materials Research Science and Engineering Center Home About Us Leadership Administration Committees Directory Research IRG 1 IRG 2 Seed 1 Seed 2 Seed 3 Highlights Publications Facilities Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher
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University of Maryland MRSEC - Collaborations: Educational
. University of Maryland Materials Research Science and Engineering Center Home About Us Leadership Administration Committees Directory Research IRG 1 IRG 2 Seed 1 Seed 2 Seed 3 Highlights Publications Facilities Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher
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Computational Prediction of Atomic Structures of Helical Membrane Proteins Aided by EM Maps
Kovacs, Julio A.; Yeager, Mark; Abagyan, Ruben
2007-01-01
Integral membrane proteins pose a major challenge for protein-structure prediction because only ≈100 high-resolution structures are available currently, thereby impeding the development of rules or empirical potentials to predict the packing of transmembrane α-helices. However, when an intermediate-resolution electron microscopy (EM) map is available, it can be used to provide restraints which, in combination with a suitable computational protocol, make structure prediction feasible. In this work we present such a protocol, which proceeds in three stages: 1), generation of an ensemble of α-helices by flexible fitting into each of the density rods in the low-resolution EM map, spanning a range of rotational angles around the main helical axes and translational shifts along the density rods; 2), fast optimization of side chains and scoring of the resulting conformations; and 3), refinement of the lowest-scoring conformations with internal coordinate mechanics, by optimizing the van der Waals, electrostatics, hydrogen bonding, torsional, and solvation energy contributions. In addition, our method implements a penalty term through a so-called tethering map, derived from the EM map, which restrains the positions of the α-helices. The protocol was validated on three test cases: GpA, KcsA, and MscL. PMID:17496035
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Home | SREL Herpetology Program
Savannah River Ecology Laboratory Herpetology Program Herp Home Research Publications Herps of SC /GA P.A.R.C. Outreach SREL Home powered by Google Search Herpetology at SREL The University of SREL herpetology research programs have always included faculty of the University of Georgia, post
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Naval Sea Systems Command > Home
Parties Vehicles for Partnering STEM Programs FIRST LEGO League Robotics Program Carderock Math Contest Educational Partnership Agreements Math Clubs Seaplane Challenge Calculator-Controlled Robot Program Students - 'Fun Twist on Math' May 24, 2018 More SOCIAL MEDIA Facebook Logo Join us live as we commission
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Massachusetts | Midmarket Solar Policies in the United States | Solar
Research | NREL Massachusetts Massachusetts An arrow graphic shows that Massachusetts's retail rate. State Incentive Programs Program Administrator Incentive Leading By Example Solar PV Canopy Environmental Affairs: Leading by Example Program Other MassSolar: Solar Policies and Resources Massachusetts
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University of Maryland MRSEC - For Members: Opportunities
. University of Maryland Materials Research Science and Engineering Center Home About Us Leadership Administration Committees Directory Research IRG 1 IRG 2 Seed 1 Seed 2 Seed 3 Highlights Publications Facilities Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher
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University of Maryland MRSEC - Education: Community
; (we call this type of surface a vicinal surface). Modern scanned-probe microscopes, such as the STM Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher MRSEC Templates Opportunities Search Home » Education » Community Outreach Community Outreach
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University of Maryland MRSEC - About Us: Committees
; (we call this type of surface a vicinal surface). Modern scanned-probe microscopes, such as the STM Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher -2014 IRG 1 Donna Hammer Hammer, Donna MRSEC Associate Director & Director of Education Outreach
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South Dakota | Solar Research | NREL
South Dakota. Utilities and developers may offer community solar programs. State Incentive Programs Program Administrator Incentive Renewable Energy System Exemption South Dakota Department of Revenue and more than $2 million. The incentive was designed for wind, but solar PV is also eligible. Utility
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University of Maryland MRSEC - Facilities: Float Zone Furnace
. University of Maryland Materials Research Science and Engineering Center Home About Us Leadership Administration Committees Directory Research IRG 1 IRG 2 Seed 1 Seed 2 Seed 3 Highlights Publications Facilities Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher
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University of Maryland MRSEC - About Us: Adminsitration
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University of Maryland MRSEC - For Members: Shipping
. University of Maryland Materials Research Science and Engineering Center Home About Us Leadership Administration Committees Directory Research IRG 1 IRG 2 Seed 1 Seed 2 Seed 3 Highlights Publications Facilities Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher
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University of Maryland MRSEC - For Members: Facilities
. University of Maryland Materials Research Science and Engineering Center Home About Us Leadership Administration Committees Directory Research IRG 1 IRG 2 Seed 1 Seed 2 Seed 3 Highlights Publications Facilities Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher
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NOAA Office of Exploration and Research > Data Access > Publications
2014 Funding Opportunities Contact Us Program Review Review Panel Final Report Review Team Documents Affiliate Locations Strategic Plan 2014 Funding Opportunities Contact Us Program Review Review Panel Final Report Review Team Documents Presentations Supporting Documents Guiding Documents Exploration Overview
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Institute for Water and Watersheds | | Oregon State University
Program OSU Hydrophiles Club Featured Projects Student Research Sponsored Events Willamette Water 2100 ; Facilities Water Resources Graduate Program OSU Hydrophiles Club Featured Projects Student Research Sponsored Kemper kayaking in the Opal Creek Wilderness. Combining Water Adventure & Research A love of kayaking
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NOAA Office of Exploration and Research > About OER > Program Review
Organization Guiding Documents Organizational Structure Map of Staff and Affiliate Locations Strategic Plan Media News Room OER Symposium Overview Organization Guiding Documents Organizational Structure Map of Program Review Home About OER Overview Organization Guiding Documents Organizational Structure Map of
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The Next Linear Collider Program
. Records including program management records, financial records, technical and R&D data needed to international collaboration including BINP (Protvino), DESY, FNAL, KEK, LAL d'Orsay, MPI (Munich) and SLAC. SLAC scientific records for proper NLC documentation. Both paper and electronic files are archived in conjunction
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NREL to Work with 14 Additional Small Businesses as Part of the DOE Small
Business Vouchers Program | NREL | News | NREL to Work with 14 Additional Small Businesses as Part of the DOE Small Business Vouchers Program News Release: NREL to Work with 14 Additional Small Businesses as Part of the DOE Small Business Vouchers Program May 2, 2017 The U.S. Department of Energy's
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Conformational Dynamics inside Amino-Terminal Disease Hotspot of Ryanodine Receptor
Zhong, Xiaowei; Liu, Ying; Zhu, Li; Meng, Xing; Wang, Ruiwu; Van Petegem, Filip; Wagenknecht, Terence; Wayne Chen, S. R.; Liu, Zheng
2013-01-01
Summary The N-terminal region of both skeletal and cardiac ryanodine receptor is a disease mutation hotspot. Recently, a crystal structure of the RyR1 fragment (residues 1-559) was solved. This N-terminal structure contains three separate domains, A, B, and C, and was docked into a central vestibule in a full-length RyR1 cryo-EM map. Here we reconstructed 3D cryo-EM structures of two GFP-tagged RyR2s with GFP inserted after residue Glu-310 and Ser-437, respectively. The structures of RyR2E310-GFP and RyR2S437-GFP displayed an extra mass on domain B and C, directly validating the predicted docking model. Next, we revealed domain movements in molecular dynamics flexible fitting models in both the closed and open state cryo-EM maps. To further probe the conformational changes, we generated FRET pairs by inserting CFP or YFP in two selected domains, FRET studies of three dual-insertion pairs and three co-expressed single-insertion pairs showed the dynamic structural changes within the N-terminal domains. PMID:24139989
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New Jersey | Midmarket Solar Policies in the United States | Solar Research
| NRELA> Jersey New Jersey An arrow graphic shows that New Jersey's renewable portfolio standard property by a renewable system is exempt from property tax. Utility Incentive Programs The Board of Public incentive programs. Renewable Portfolio Standard New Jersey Board of Public Utilities: RPS Background New
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ACHP | News | ACHP Issues Program Comment for Disposal of Navy vessels
Search skip specific nav links Home arrow News arrow ACHP Issues Program Comment for Disposal of Navy vessels ACHP Issues Program Comment for Disposal of Navy vessels March 8, 2010 Â The Advisory Council on Historic Preservation (ACHP) has issued a Program Comment, pursuant to 36 CFR 800.14(e), to the U.S. Navy
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Poker Flats Mine - Div. of Mining, Land, and Water
Lands Coal Regulatory Program Large Mine Permits Mineral Property and Rights Mining Index Land Fishery Water Resources Factsheets Forms banner image of landscape Poker Flats Mine Home Mining Coal Regulatory Program Poker Flats Mine Mining Coal Regulatory Program Info Chickaloon Chuit Watershed Chuitna
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Ocean Drilling Program: Cruise Information
Morgan. Cruise Information The Ocean Drilling Program ended on 30 September 2003 and has been succeeded by the Integrated Ocean Drilling Program (IODP). The U.S. Implementing Organization (IODP-USIO ) (Consortium for Ocean Leadership, Lamont-Doherty Earth Observatory, and Texas A&M University) continues to
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, through astronomy. It also promote full access of all people in the Region of Coquimbo to their facilities the subject of astronomy. 1999 The Student Network of La Serena is an organization formed in August Planetarium NOAO-S School Astronomy Program Astronomical Observation Program Astrophotograpy Program â¹ NOAO
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WinHPC System Programming | High-Performance Computing | NREL
Programming WinHPC System Programming Learn how to build and run an MPI (message passing interface (mpi.h) and library (msmpi.lib) are. To build from the command line, run... Start > Intel Software Development Tools > Intel C++ Compiler Professional... > C++ Build Environment for applications running
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Lydia Finney appointed WIST program initiator - Argonne Today
Home Mission People Work/Life Connections Focal Point Inside Argonne Argonne Public Website Argonne Today Argonne Today Mission People Work/Life Connections Focal Point Lydia Finney appointed WIST program initiator Home People Lydia Finney appointed WIST program initiator Lydia Finney appointed WIST
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Under Secretary of Defense for Policy > OUSDP Offices > ASD for
cooperation programs and foreign military sales programs in these regions. Responsibilities and Functions The defense establishments; and for oversight of security cooperation programs and foreign military sales all foreign governments in assigned areas of responsibility. Develop regional security and defense
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Update History NOAAPORT Technical Contacts NOAAPORT Program Overview NOAAPORT Reference Documentation NOAAPORT Update History - for the NOAAPORT Program. NOAAPORT Technical Contacts - NWS Technical Points of Alignment Information. Receiver Characteristics - Technical Characteristics of the NOAAPORT Receiver. Data
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Sandia National Laboratories: Careers: Special Programs
Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios
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Welcome to CALFED Bay-Delta Program
Skip to: Content | Footer | Accessibility Search: Search CALFED Search CA.GOV | CALFED Bay-Delta California Delta Delta Home About the Delta CALFED Science About the Program Independent Science Board , CALFED Director photo of blue heron Bay-Delta Public Advisory Committee CALFED Agencies Calendar
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Defense Threat Reduction Agency > Careers > Strategic Recruiting Programs
graduate science, mathematics and engineering students. Students are offered these scholarships and graduate science, mathematics and engineering students. Students are offered scholarships and fellowships with disabilities, please call (703) 767-4451. Workforce Recruitment Program for College Students with
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Family Programs News - The National Guard
ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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State Partnership Program News - The National Guard
ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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Small Business Programs - The National Guard
ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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USPAS | U.S. Particle Accelerator School
U.S. Particle Accelerator School U.S. Particle Accelerator School U.S. Particle Accelerator School U.S. Particle Accelerator School Education in Beam Physics and Accelerator Technology Home About About University Credits Joint International Accelerator School University-Style Programs Symposium-Style Programs
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NREL: International Activities - Bilateral Partnerships
development and use of renewable energy and energy efficiency technologies: Algeria Angola Argentina Australia sufficiently accurate information for national-level strategic energy planning. China NREL manages renewable energy cooperation with China under the U.S.-China Renewable Energy Partnership program. This program was
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Program (USAP) sister projects focusing on observational Antarctic meteorological research, providing real -Madison Antarctic Meteorological Research Center & Automatic Weather Stations Project The Antarctic Meteorological Research Center (AMRC) and Automatic Weather Station (AWS) program are United States Antarctic
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Sandia National Laboratories: Community Involvement: Volunteer Programs
Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios
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Ocean Drilling Program: Science Operator
: www.odplegacy.org Integrated Ocean Drilling Program (IODP): www.iodp.org IODP U.S. Implementing Organization (IODP -USIO): www.iodp-usio.org The Ocean Drilling Program (ODP) was funded by the U.S. National Science Foundation and 22 international partners (JOIDES) to conduct basic research into the history of the ocean
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IT Resources - Betty Petersen Memorial Library
Available NOAA-wide. Note: This link takes you to a nonfederal website. Guide for usage Apress.com Free eBooks Free eBooks available through Apress publishers. Topics include PHP, Perl, and programming VB .Net . Note: This link takes you to a nonfederal website. Online Programming Books Free programming books
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Alternative Fuels Data Center: Voucher Incentive Programs: Lessons From the
. For example, most programs provide funding on a first-come, first-served basis. Programs to date have incentives for HVIP to increase regional fuel and emissions reductions. For example, the San Joaquin Valley Energy Research and Development Authority (NYSERDA) is administering the New York Truck - Voucher
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Albert LiVecchi Photo of Al Livecchi Albert LiVecchi Laboratory Program Manager- Water Power Al.Livecchi@nrel.gov | 303-384-7138 Al has been part of the Wind and Water Power Program Management Team at focuses on marine and hydrokinetic technologies. As Water Power Laboratory Program Manager, Al is
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NOAA Workforce Management Office
Home Careers at NOAA Search Criteria Click to Search WORKFORCE MANAGEMENT OFFICE NATIONAL OCEANIC Executive Service ST and SL Responsibilities Performance Management Performance Management Resources Portal Management Fellows (PMFs) Program Coordination Office - Leadership Development Program (PCO-LDP) Employee
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Technical Risk Analysis for the Geothermal Technologies ProgramPDF. Golden, CO: National Renewable Energy analysis and planning activities (PAE Hub) Research Interests Analytical support to Geothermal Technologies Program, including assessment of the competitiveness of geothermal electricity generation Investigation of
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University of Maryland MRSEC - For Members: Purchasing
Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher next to each file. Purchasing Policies & Procedures Purchases of products and services require pre
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; (we call this type of surface a vicinal surface). Modern scanned-probe microscopes, such as the STM Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher
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University of Maryland MRSEC - For Members: Travel
Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher University of Maryland requires pre-approval for all travel. Domestic travel approval requests must be
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Kansas Department of Health and Environment - Immunization Program
Immunize and Win a Prize Click on Immunize Win a Prize logo for more information Yellow Fever Click on the logo above for more information on Yellow Fever PERINATAL HEPATITIS B PREVENTION PROGRAM Click on logo
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CIDR Program Contacts NIH CIDR Program Application Information Barbara Thomas, Ph.D. Scientific Review | Site Map | Get Adobe Reader Subscribe to CIDR News photo of lab tech A Research Technologist examines a
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University of Maryland MRSEC - For Members
; (we call this type of surface a vicinal surface). Modern scanned-probe microscopes, such as the STM Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher
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University of Maryland MRSEC - News: Calendar
; (we call this type of surface a vicinal surface). Modern scanned-probe microscopes, such as the STM Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher
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Fermilab Friends for Science Education | Calendar
Archives Scholarships Programs Current Programs Historical Review Testimonials Our Donors Board of Directors Board Tools Calendar Join Us Donate Now Get FermiGear! Education Office Search Programs Calendar
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Fermilab Friends for Science Education | Mission
Archives Scholarships Programs Current Programs Historical Review Testimonials Our Donors Board of Directors Board Tools Calendar Join Us Donate Now Get FermiGear! Education Office Search Programs Calendar
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IN2 Program Validates Data Center Cooling Solution | News | NREL
IN2 Program Validates Data Center Cooling Solution February 21, 2018 IN2 Program Validates Data Center Cooling Solution NREL researchers and LiquidCool Solutions representatives stand along-side centers on average consuming an estimated 70 billion kWh per year, a disruptive energy-saving solution is
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NOAA Photo Library - Meet the Photographers/Dr. Michael Van Woert
, California. In January 1993 he assumed duties as the program scientist for the NASA TOPEX/POSEIDON altimeter mission and program manager for the Physical Oceanography Program at NASA Headquarters. The only snow and ice he encountered during the two years at NASA was above average winter snowfall on the streets of
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Solar Resources for Local Governments | State, Local, and Tribal
integrating photovoltaic systems throughout the city. City and County Solar Photovoltaics Training Program NREL is offering a no-cost PV training program for 50 cities and counties seeking to go solar on their facilities-both buildings and land. For detailed information on the training program, view the City and
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National CPS Certification | A Program of Safe Kids Worldwide
the Tech! ABOUT THE PROGRAM National CPS Certification Training is a program of Safe Kids Worldwide ; E-Vouchers FAQS/HELP FAQs Fees Forms Policies & Procedures Who We Are NHTSA Safe Kids CPS-board State Farm Follow us on Facebook Copyright © 2017 by Safe Kids Worldwide - Child Passenger Safety
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Solar University-National Lab Ultra-Effective Program | Photovoltaic
Lab Ultra-Effective Program Solar University-National lab Ultra-effective Program (SUN UP) was created scientists arise out of long-standing collaborations. SUN UP was created to facilitate these interactions of a young man working in a laboratory setting with equipment. The goal of SUN UP is to increase the
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NOVA - Official Website | The Pluto Files
December 14, 2011 on PBS Program Description (Program not available for streaming.) When the American : So that's when most people first learn about the planets. So his name comes up, and you learn he's a DEGRASSE TYSON (American Museum of Natural History, Hayden Planetarium): In 1930, a farm boy, with a
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Skip Navigation medication-assisted treatment for substance use disorders Back to MAT home  Opioid Treatment Program Directory Select to view the opioid treatment programs in a State - Select - All Substance Abuse Treatment Division of Pharmacologic Therapies 5600 Fishers Lane * Rockville, MD 20857 * 240
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University of Maryland MRSEC - For Members: Templates
; (we call this type of surface a vicinal surface). Modern scanned-probe microscopes, such as the STM Educational Education Pre-College Programs Homeschool Programs Undergraduate & Graduate Programs Teacher
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ACHP | ACHP Native American Program: Guidance for Federal Agencies
Working with Section 106 Federal, State, & Tribal Programs Training & Education Publications Search skip specific nav links Home arrow Working with Section 106 arrow ACHP Native American Program
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Links Continuing Health Education Non-BSO 18 Funding ACADEMIC PROGRAMS Management & Specialty /Selection Information Reservist Information Operational Course Nomination Form Non-operational Course Commissioning Programs Graduate Medical Education Continuing Medical Education Continuing Health Education Non
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United States Census Bureau Topics Population Latest Information Age and Sex Ancestry Children Mobility Population Estimates Population Projections Race Veterans Economy Latest Information Portal Other Economic Programs Business Latest Information Business Characteristics Classification Codes
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United States Census Bureau Topics Population Latest Information Age and Sex Ancestry Children Mobility Population Estimates Population Projections Race Veterans Economy Latest Information Portal Other Economic Programs Business Latest Information Business Characteristics Classification Codes
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United States Census Bureau Topics Population Latest Information Age and Sex Ancestry Children Mobility Population Estimates Population Projections Race Veterans Economy Latest Information Portal Other Economic Programs Business Latest Information Business Characteristics Classification Codes
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United States Census Bureau Topics Population Latest Information Age and Sex Ancestry Children Mobility Population Estimates Population Projections Race Veterans Economy Latest Information Portal Other Economic Programs Business Latest Information Business Characteristics Classification Codes
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PEER Transportation Research Program | PEER Transportation Research Program
methodologies, integrating fundamental knowledge, enabling technologies, and systems. We further expect that the Bayesian Framework for Performance Assessment and Risk Management of Transportation Systems subject to Earthquakes Directivity Modeling for NGA West2 Ground Motion Studies for Transportation Systems Performance
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Gas Hydrates | Alaska Division of Geological & Geophysical Surveys
R&D Program USGS Energy Resources Program Industry and professional associations AAPG - Energy Alaska's Mineral Industry Reports AKGeology.info Rare Earth Elements WebGeochem Engineering Geology Alaska collaboratively with federal, university, and industry researchers to assess Alaska's gas hydrate resource
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PEER Business and Industry Partnership (BIP)
PEER logo Pacific Earthquake Engineering Research Center home about peer news events research Industry Partnership (BIP) Industry and government partners are an integral part of the research program at research and education programs and provides access to PEER researchers and products. Researchers share
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Documents | Office of Marine and Aviation Operations
; Facilities Public & Legislative Affairs Publication Regulation Report Safety Security Specifications ) 2007 NOAA Diving Program Annual Report This report highlights the significant achievements of the NOAA Program, Office of Marine and Aviation Operation, Report Download from OMAO OMAO (2008) 2008 NOAA Diving
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NREL: International Activities - Country Programs
for use of mini-grid quality assurance and design standards and advising on mini-grid business models communities of practice and technical collaboration across countries on mini-grid development, modeling and interconnection standards and procedures, and with strengthening mini-grids and energy access programs. NREL is
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Advisors, Centers and Research Programs
United States Census Bureau Topics Population Latest Information Age and Sex Ancestry Children Mobility Population Estimates Population Projections Race Veterans Economy Latest Information Portal Other Economic Programs Business Latest Information Business Characteristics Classification Codes
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Sandia National Laboratories: Careers: Benefits and Perks
Medical Leave Act and the California Family Rights Act Extended leave of absence for child, family, or medical care; military duty; and personal reasons Health programs Health programs Medical, dental, and
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Snoberger, Aaron; Brettrager, Evan J; Smith, David M
2018-06-18
Protein degradation in all domains of life requires ATPases that unfold and inject proteins into compartmentalized proteolytic chambers. Proteasomal ATPases in eukaryotes and archaea contain poorly understood N-terminally conserved coiled-coil domains. In this study, we engineer disulfide crosslinks in the coiled-coils of the archaeal proteasomal ATPase (PAN) and report that its three identical coiled-coil domains can adopt three different conformations: (1) in-register and zipped, (2) in-register and partially unzipped, and (3) out-of-register. This conformational heterogeneity conflicts with PAN's symmetrical OB-coiled-coil crystal structure but resembles the conformational heterogeneity of the 26S proteasomal ATPases' coiled-coils. Furthermore, we find that one coiled-coil can be conformationally constrained even while unfolding substrates, and conformational changes in two of the coiled-coils regulate PAN switching between resting and active states. This switching functionally mimics similar states proposed for the 26S proteasome from cryo-EM. These findings thus build a mechanistic framework to understand regulation of proteasome activity.
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Conformational states of the full-length glucagon receptor
Yang, Linlin; Yang, Dehua; de Graaf, Chris; Moeller, Arne; West, Graham M.; Dharmarajan, Venkatasubramanian; Wang, Chong; Siu, Fai Y.; Song, Gaojie; Reedtz-Runge, Steffen; Pascal, Bruce D.; Wu, Beili; Potter, Clinton S.; Zhou, Hu; Griffin, Patrick R.; Carragher, Bridget; Yang, Huaiyu; Wang, Ming-Wei; Stevens, Raymond C.; Jiang, Hualiang
2015-01-01
Class B G protein-coupled receptors are composed of an extracellular domain (ECD) and a seven-transmembrane (7TM) domain, and their signalling is regulated by peptide hormones. Using a hybrid structural biology approach together with the ECD and 7TM domain crystal structures of the glucagon receptor (GCGR), we examine the relationship between full-length receptor conformation and peptide ligand binding. Molecular dynamics (MD) and disulfide crosslinking studies suggest that apo-GCGR can adopt both an open and closed conformation associated with extensive contacts between the ECD and 7TM domain. The electron microscopy (EM) map of the full-length GCGR shows how a monoclonal antibody stabilizes the ECD and 7TM domain in an elongated conformation. Hydrogen/deuterium exchange (HDX) studies and MD simulations indicate that an open conformation is also stabilized by peptide ligand binding. The combined studies reveal the open/closed states of GCGR and suggest that glucagon binds to GCGR by a conformational selection mechanism. PMID:26227798
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Dr. William Tumas - Associate Laboratory Director, Materials and Chemical
Chemical Science and Technology Dr. William Tumas - Associate Laboratory Director, Materials and Chemical , technical direction, and workforce development of the materials and chemical science and technology , program management, and program execution. He joined NREL in December 2009 as Director of the Chemical and
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OHD/HL - National Weather Hydrology Laboratory
resources and services. Design and Programming Standards and Guidelines General Programming C C++ FORTRAN Java v 2.0 updated 3/28/2008 Java v 1.9 Korn and Bash Shell Software Design Phase Guidelines OHD Design Specification Template OHD Design Specification Example Software Peer Review Guidelines and Checklists Software
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Preserve America - Explore and Enjoy Our Heritage
House announcement here. New Report Cites Historic Tax Credits Create Thousands of Jobs and Billions of historic tax incentives program. Commonly known as the Historic Tax Credit, the program provides a 20 percent federal tax credit for rehabilitation of historic buildings for business or income-producing uses
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Federal support for state and local response operations - PHE
Electronic Benefits Transfer program, which provides summertime nutrition assistance to children who receive 15, a USDA Food and Nutrition Service nutritionist presented USDA nutrition information and menu Nutrition Program for Women, Infants, and Children (WIC) funds to conduct lead testing for WIC participants
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Energy Conservation Programs | Climate Neutral Research Campuses | NREL
. Recognize accomplishments. One common theme is that successful programs check in often with the target very small scale with one building or one department. The success and savings from that effort can then be used to grow incrementally. Harvard University adopted this approach, where investment in one
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Announcement Notice (AN) 241.4 - Software | OSTI, US Dept of Energy Office
of Scientific and Technical Information Skip to main content Scientific and Technical Information Program The home of the U.S. Department of Energy's Scientific and Technical Information Program ) Scientific and Technical Information (STI) products for announcement and availability. An AN includes review
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electric power professionals. Prior to that, Alex spent 15 years with Crain Communications' RCR Wireless @nrel.gov | 303-384-7018 As the Wind and Water Power Program Communications Team Lead, Alex serves as the primary interface to the Wind and Water Power Program management team to develop communication strategies
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Science at Fermilab Fermilab and the Higgs Boson Frontiers of Particle Physics Experiments & Projects Frontiers of Particle Physics Benefits to Society Contacting Fermilab General Contact Information Email -12 Programs Lederman Science Center Saturday Morning Physics Cooperative Education Program
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Emergency management training program: Guide to good practice
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1991-07-01
The Emergency Management Training Program Guide to Good Practice is a project of the Training Resources and Data Exchange (TRADE) Emergency Management Issues Special Interest Group (EMI SIG). EMI SIG members expressed interest in a resource to assist in development of a comprehensive emergency management training program. This publication provides guidelines, methods, and materials for EMI SIG members to use, assisting in complete and effective emergency management programs. The purposes of the Emergency Management Training Program Guide to Good Practice are: Provide guidance in the development and management of Emergency Management (EM) training programs; Assist EM trainers to incorporate componentsmore » of the DOE Emergency Management System philosophy of planning, preparedness, readiness assurance, and response into EM training programs; Help EM training managers meet EM training requirements and conditions established by current regulations and policies; Supplement other TRADE EMI SIG documents and complement individual facility training documents. This program is designed for emergency management personnel who are responsible for providing or overseeing EM training but who do not necessarily possess expertise in developing training. It provides good practices from the manager's point of view on how to produce, administer, and document facility EM training programs in the spirit of the DOE EM system philosophy. Basic guidance is also included for personnel who design, develop, deliver, and/or evaluate EM training programs or parts. This guidance includes key points of EM training programs and identifies other documents that contain useful and/or more detailed training information.« less
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Emergency management training program: Guide to good practice
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1991-07-01
The Emergency Management Training Program Guide to Good Practice is a project of the Training Resources and Data Exchange (TRADE) Emergency Management Issues Special Interest Group (EMI SIG). EMI SIG members expressed interest in a resource to assist in development of a comprehensive emergency management training program. This publication provides guidelines, methods, and materials for EMI SIG members to use, assisting in complete and effective emergency management programs. The purposes of the Emergency Management Training Program Guide to Good Practice are: Provide guidance in the development and management of Emergency Management (EM) training programs; Assist EM trainers to incorporate componentsmore » of the DOE Emergency Management System philosophy of planning, preparedness, readiness assurance, and response into EM training programs; Help EM training managers meet EM training requirements and conditions established by current regulations and policies; Supplement other TRADE EMI SIG documents and complement individual facility training documents. This program is designed for emergency management personnel who are responsible for providing or overseeing EM training but who do not necessarily possess expertise in developing training. It provides good practices from the manager`s point of view on how to produce, administer, and document facility EM training programs in the spirit of the DOE EM system philosophy. Basic guidance is also included for personnel who design, develop, deliver, and/or evaluate EM training programs or parts. This guidance includes key points of EM training programs and identifies other documents that contain useful and/or more detailed training information.« less
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Injuries to emergency medicine residents on EMS rotations.
Cone, D C; McNamara, R M
1998-01-01
To study the incidence and nature of injuries sustained by emergency medicine (EM) residents during EMS rotations, and steps taken at EM residency programs to increase resident safety during field activities. An eight-question survey form was mailed to all 114 U.S. EM residency directors, with a second mailing to nonresponders eight weeks after the initial mailing. A total of 105 surveys were returned (92%). Six surveys were from new programs whose residents have not yet rotated on EMS. These were excluded from further analysis, leaving 99 programs. Of these, 91 (92%) reported no injuries. One EM resident died in a helicopter crash in 1985. Seven other injury events were reported: 1) facial lacerations, rib fractures, and a shoulder injury in an ambulance accident; 2) an open finger fracture (crushed by a backboard); 3) contusions and a concussion when an ambulance was struck by a fire engine; 4) a groin pull sustained while entering a helicopter; 5) bilateral metatarsal fractures in a fall; 6) rib fractures, a pneumothorax, and a concussion in an ambulance accident; and 7) "minor injuries" sustained in a crash while responding to a scene in a program-owned response vehicle. Actions taken at residency programs to reduce the risk of injury include the use of ballistic vests (four programs), requiring helmets on flights (five programs), and changing flight experience from mandatory to optional (two programs). Ten programs (10%) reported using ground scene safety lectures, and nine programs (15% of those offering flights) reported various types of flight safety instruction. Sixty-nine programs (70%) reported no formal field safety training or other active steps to increase resident safety on EMS rotations. Injuries sustained by EM residents during EMS rotations are uncommon but nontrivial, with several serious injuries and one fatality reported. The majority of EM residency programs have no formal safety training programs for EMS rotations.
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Radiation Pattern of Chair Armed Microstrip Antenna
NASA Astrophysics Data System (ADS)
Mishra, Rabindra Kishore; Sahu, Kumar Satyabrat
2016-12-01
This work analyzes planar antenna conformable to chair arm shaped surfaces for WLAN application. Closed form expressions for its radiation pattern are developed and validated using measurements on prototype and commercial EM code at 2.4 GHz.
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Ocean Drilling Program: Privacy Policy
and products Drilling services and tools Online Janus database Search the ODP/TAMU web site ODP's main web site ODP/TAMU Science Operator Home Ocean Drilling Program Privacy Policy The following is the privacy policy for the www-odp.tamu.edu web site. 1. Cookies are used in the Database portion of the web
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Fermilab Education Office - Director's Award
. He has given Ask-A-Scientist lectures, talked at the Family Open House, performed in the Physics Slam , and given tours for Saturday Morning Physics. He is active in our KÂ12 programs and beyond by Saturday Morning Physics program has engendered a love of physics in thousands of high school students
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ACHP | News | Four Federal Agencies Honored For Preserve America
. The National Aeronautics and Space Administration (NASA) also responded in an exemplary manner. With the forthcoming phase-out of the Shuttle Program, NASA reported on tremendous strides it has made in future NASA programs. It is evident that the commitments made by NASA in its 2005 Section 3 Progress
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Copyrighted Software | OSTI, US Dept of Energy Office of Scientific and
Technical Information Skip to main content Scientific and Technical Information Program The home of the U.S. Department of Energy's Scientific and Technical Information Program (STIP) Here you Energy U.S. Department of Energy Office of Science Office of Scientific and Technical information Website
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Application Deadline Program Dates CCI October 16, 2017 January 12, 2018 June 4ÂAugust 10, 2018 GEM August 31, 2018 Lee Teng November 2017 January 22, 2018 May 29ÂAugust 10, 2018 QuarkNet March 19, 2018 August 10, 2018 SULI October 16, 2017 January 12, 2018 June 4ÂAugust 10, 2018 TARGET December 18, 2017
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- Oklahoma Water Resources Center
INTERDISCIPLINARY PROGRAMS Environmental Sciences Master of International Agriculture Degree Program OSU Home Professional Development Training (Baton Rouge, LA; 8/5-10) Global Water Security for Agriculture and Natural Oklahoma City Center for Health Sciences Division of Agriculture Institute of Technology Veterinary
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ACHP | Federal Programs that Can Support Heritage Tourism
farmers and ranchers in exploring alternate economic enterprises, including heritage tourism.(http Rural Business Enterprise Grants, Rural Business Opportunity Grants, and Rural Economic Development /td/mdcp/) Public Works, Economic Adjustment, Planning, and Research and Technical Assistance Programs
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ACHP | Federal Emergency Management Agency Historic Preservation Program
and Historic Preservation Review: https://www.fema.gov/fema-activities-may-trigger-environmental -historic-review FEMA's Environmental & Historic Preservation Guidance for Grant Applicants: http Historic Preservation Review: http://www.fema.gov/environmental-planning-and-historic-preservation-program
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NBIC: National Ballast Information Clearinghouse
Smithsonian Environmental Research Center Logo US Coast Guard Logo Submit BW Report | Search NBIC Database / Database Manager: Tami Huber Senior Analyst / Ecologist: Mark Minton Data Managers Ashley Arnwine Jessica Hardee Amanda Reynolds Database Design and Programming / Application Programming: Paul Winterbauer
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Array Manipulation Program (LAMP): IDL-based data analysis and visualization Open Genie: interactive -ray powder data ORTEP: Oak Ridge Thermal Ellipsoid Plot program for crystal structure illustrations structure VRML generator aClimax: modeling of inelastic neutron spectroscopy using Density Functional Theory
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Effect of changes in graduate medical education funding on emergency medicine residency programs.
Stead, L; Schafermeyer, R W; Counselman, F L; Blackburn, P; Perina, D
2001-06-01
To determine whether changes in graduate medical education (GME) funding have had an impact on emergency medicine (EM) residency training programs. A 34-question survey was mailed to the program directors (PDs) of all 115 Accreditation Council for Graduate Medical Education (ACGME)-accredited EM residency programs in the United States in the fall of 1998, requesting information concerning the impact of changes in GME funding on various aspects of the EM training. The results were then compared with a similar unpublished survey conducted in the fall of 1996. One hundred one completed surveys were returned (88% response rate). Seventy-one (70%) of the responding EM residency programs were PGY-I through PGY-III, compared with 55 (61%) of the responding programs in 1996. The number of PGY-II through PGY-IV programs decreased from 25 (28%) of responding programs in 1996 to 17 (16%). The number of PGY-I through PGY-IV programs increased slightly (13 vs 10); the number of EM residency positions remained relatively stable. Fifteen programs projected an increase in their number of training positions in the next two years, while only three predicted a decrease. Of the respondents, 56 programs reported reductions in non-EM residency positions and 35 programs reported elimination of fellowship positions at their institutions. Only four of these were EM fellowships. Forty-six respondents reported a reduction in the number of non-EM residents rotating through their EDs, and of these, 11 programs reported this had a moderate to significant effect on their ability to adequately staff the ED with resident physicians. Sixteen programs limited resident recruitment to only those eligible for the full three years of GME funding. Eighty-seven EM programs reported no change in faculty size due to funding issues. Sixty-two programs reported no change in the total number of hours of faculty coverage in the ED, while 34 programs reported an increase. Three EM programs reported recommendations being made to close their residency programs in the near future. Changes in GME funding have not caused a decrease in the number of existing EM residency and fellowship training positions, but may have had an impact in other areas, including: an increase in the number of EM programs structured in a PGY-I through PGY-III format (with a corresponding decrease in the number of PGY-II through PGY-IV programs); a decrease in the number of non-EM residents rotating through the ED; restriction of resident applicants who are ineligible for full GME funding from consideration by some EM training programs; and an increase in the total number of faculty clinical hours without an increase in faculty size.
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Lee, Hyunwook; Brendle, Sarah A.; Bywaters, Stephanie M.; Guan, Jian; Ashley, Robert E.; Yoder, Joshua D.; Makhov, Alexander M.; Conway, James F.; Christensen, Neil D.
2014-01-01
ABSTRACT Human papillomavirus 16 (HPV16) is a worldwide health threat and an etiologic agent of cervical cancer. To understand the antigenic properties of HPV16, we pursued a structural study to elucidate HPV capsids and antibody interactions. The cryo-electron microscopy (cryo-EM) structures of a mature HPV16 particle and an altered capsid particle were solved individually and as complexes with fragment of antibody (Fab) from the neutralizing antibody H16.V5. Fitted crystal structures provided a pseudoatomic model of the virus-Fab complex, which identified a precise footprint of H16.V5, including previously unrecognized residues. The altered-capsid–Fab complex map showed that binding of the Fab induced significant conformational changes that were not seen in the altered-capsid structure alone. These changes included more ordered surface loops, consolidated so-called “invading-arm” structures, and tighter intercapsomeric connections at the capsid floor. The H16.V5 Fab preferentially bound hexavalent capsomers likely with a stabilizing effect that directly correlated with the number of bound Fabs. Additional cryo-EM reconstructions of the virus-Fab complex for different incubation times and structural analysis provide a model for a hyperstabilization of the capsomer by H16.V5 Fab and showed that the Fab distinguishes subtle differences between antigenic sites. IMPORTANCE Our analysis of the cryo-EM reconstructions of the HPV16 capsids and virus-Fab complexes has identified the entire HPV.V5 conformational epitope and demonstrated a detailed neutralization mechanism of this clinically important monoclonal antibody against HPV16. The Fab bound and ordered the apical loops of HPV16. This conformational change was transmitted to the lower region of the capsomer, resulting in enhanced intercapsomeric interactions evidenced by the more ordered capsid floor and “invading-arm” structures. This study advances the understanding of the neutralization mechanism used by H16.V5. PMID:25392224
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Collaboration Careers Community Environment Science & Innovation Facilities Science Pillars Research Library Science Briefs Science News Science Highlights Lab Organizations Science Programs Applied Energy Programs
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Collaboration Careers Community Environment Science & Innovation Facilities Science Pillars Research Library Science Briefs Science News Science Highlights Lab Organizations Science Programs Applied Energy Programs
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Berkeley Lab - Materials Sciences Division
Chemical and Mechanical Properties of Surfaces, Interfaces and Nanostructures Inorganic-Organic (2016). top Inorganic-Organic Nanocomposites Program Leader: Ting Xu Co-PI's: A. Paul Alivisatos, Yi Liu , Miquel Salmeron, Lin-Wang Wang The organic/inorganic nanocomposite program aims to design and synthesize
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Sandia National Laboratories: About Sandia: Community Involvement:
DOE Regional Science Bowls - New Mexico DOE Regional Science Bowls - California Family Math Night Family Science Night Science, Technology, Engineering, and Math Programs About Education Programs a national concern. Encouraging students to pursue science, technology, engineering, and math (STEM
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Preserve America Clearinghouse
and in partnership with the U.S. Departments of Agriculture, Commerce, Defense, Education, Housing and United States Advisory Council on Historic Preservation logo U.S. Department of Agriculture logo U.S Agriculture USDA Forest Service Heritage Program "Passport in Time" Program Department of Commerce
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Find Us | Oregon State University Extension Service
Catalog Programs 4-H Agriculture & Natural Resources Family & Community Health Forestry & -H Youth Development State Office Agriculture and Natural Resources Family and Community Health/SNAP health, community development, food and agriculture, coastal issues, forestry, programs for young people
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Department of Natural Resources logo, color scheme Department of Natural Resources Division of Agriculture Search Search DNR's site DNR State of Alaska Toggle main menu visibility Agriculture Home Programs Asset Disposals Alaska Caps Progam Board of Agriculture & Conservation Farm To School Program Grants
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Commercial Vegetables | UGA Cooperative Extension
in many county offices for ag producers. Organic Agriculture Certificate Program Understand organic agriculture production in the southeastern United States. Pesticide Safety Education Program Topics include Hill Award Gaskin's career is focused on the use of conservation methods in traditional agriculture
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Search Site submit About Us Los Alamos National LaboratoryRichard P. Feynman Center for Innovation Innovation protecting tomorrow Los Alamos National Laboratory The Richard P. Feynman Center for Innovation key programs to achieve regional technology commercialization from Los Alamos. The programs below help
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Nome Offshore Mining Information
Lands Coal Regulatory Program Large Mine Permits Mineral Property and Rights Mining Index Land potential safety concerns, prevent overcrowding, and provide for efficient processing of the permits and Regulatory Program Large Mine Permitting Mineral Property Management Mining Fact Sheets Mining Forms APMA
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vehicles. The Program will be focused on funding projects for the voluntary early retirement and . Eligible applicants that have received funding for voluntary vehicle retirement under the California Bureau of Automotive Repair's Consumer Assistance Program are eligible for vehicle replacement funding under
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Mojave Desert Ecosystem Program
Toggle navigation logo garis Home About Search Contact About Us History The Mojave Desert Ecosystem providing dynamic, sustainable, land management decision-making at the ecosystem level. Its numerous mission of the Mojave Desert Ecosystem Program is to provide government agencies throughout the Mojave
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Defense Threat Reduction Agency > Careers > Professional Development
Justifications & Approvals Careers Who We Are Our Values Strategic Recruiting Programs Professional Your Reporting Day Senior Executive Service Special Programs PROFESSIONAL DEVELOPMENT Our Training and some of the pitfalls that may derail a career or delay a promotion. Competitive Professional
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Work with us | National Oceanic and Atmospheric Administration
Research Marine & Aviation Charting Sanctuaries Education About our agency News and features Our work for scholarships, internships, fellowships and post-doctoral experiences. Opportunities for teachers Innovation Research (SBIR) Program and the Technology Transfer Program. The Technology Partnerships Office
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Ground Project, New York; the Corinth and Alcorn County Mississippi Heritage Tourism Initiative heritage tourism programs. Since the program began in 2003, 843 communities have been designated as regional press releases; official notification of designation to state tourism offices and visitors bureaus
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Alternative Fuel Vehicle (AFV) Revolving Loan Program The Mississippi Alternative Fuel School Bus and Municipal Motor Vehicle Revolving Loan Program provides zero-interest loans for public school districts and municipalities to cover the incremental cost to purchase alternative fuel school buses and
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School Bus Replacement Grant Program The Ohio Environmental Protection Agency (EPA) supports the purchase of replacement school buses in eligible Ohio counties through the Diesel Emission Reduction Grant program. Purchases are also supported with state allocated grant funding from the U.S. Environmental
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Solvent mimicry with methylene carbene to probe protein topography.
Gómez, Gabriela Elena; Monti, José Luis E; Mundo, Mariana Rocío; Delfino, José María
2015-10-06
The solvent accessible surface area (SASA) of the polypeptide chain plays a key role in protein folding, conformational change, and interaction. This fundamental biophysical parameter is elusive in experimental measurement. Our approach to this problem relies on the reaction of the minimal photochemical reagent diazirine (DZN) with polypeptides. This reagent (i) exerts solvent mimicry because its size is comparable to water and (ii) shows scant chemical selectivity because it generates extremely reactive methylene carbene. Methylation gives rise to the EM (extent of modification) signal, which is useful for scrutinizing the conformational change triggered by Ca(2+) binding to calmodulin (CaM). The increased EM observed for the full protein is dominated by the enhanced exposure of hydrophobic area in Ca(2+)-CaM. Fragmentation allowed us to quantify the methylene incorporation at specific sites. Peptide 91-106 reveals a major reorganization around the calcium 151 binding site, resulting in local ordering and a greater exposure of the hydrophobic surface. Additionally, this technique shows a high sensitivity to probe recognition between CaM and melittin (Mel). The large decrease in EM indicates the occlusion of a significant hydrophobic area upon complexation. Protection from labeling reveals a larger involvement of the N-terminal and central regions of CaM in this interaction. Despite its smaller size, Mel's differential exposure can also be quantified. Moreover, MS/MS fragmentation realizes the goal of extending the resolution of labeled sites at the amino acid level. Overall, DZN labeling emerges as a useful footprinting method capable of shedding light on physiological conformational changes and interactions.
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Running ANSYS Fluent on the WinHPC System | High-Performance Computing |
. If you don't have one, see WinHPC system user basics. Check License Use Status Start > All Jason Lustbader. Run Using Fluent Launcher Start Fluent launcher by opening: Start > All Programs > . Available node groups can be found from HPC Job Manager. Start > All Programs > Microsoft HPC Pack
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ERIC Educational Resources Information Center
Harmon, Ronald M.
1994-01-01
Examines the process through which modern Portuguese borrows from other languages, mainly French and English. Portuguese adapts these derivatives to conform to its own rules of phonology, morphology, and semantics. (four references) (Author/CK)
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ACHP | Federal Agency Historic Preservation Programs and Officers
Federal Agency Historic Preservation Programs and Officers - Agency Information Updated: April 19, 2018 Federal Preservation Officer Chief, Real Property Management Branch Facilities Division, Agricultural @wdc.usda.gov Read more information For express and courier deliveries please use the following address: USDA
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greater danger near shore or any shallow waters? NOAA PORTS PROGRAM The Physical Oceanographic Real-Time navigation by providing ship masters and pilots with accurate real-time information required to avoid data acquisition and dissemination systems that provide real-time water levels, currents, and other
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; Children Page Content WIC is the Special Supplemental Nutrition Program for Women, Infants and Children . This public health program is designed to improve health outcomes and influence lifetime nutrition and health behaviors in targeted, at-risk populations. Nutrition education is the cornerstone of the WIC
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SUNREL Related Links | Buildings | NREL
SUNREL Related Links SUNREL Related Links DOE Simulation Software Tools Directory a directory of 301 building software tools for evaluation of energy efficiency, renewable energy, and sustainability in buildings. TREAT Software Program a computer program that uses SUNREL and is designed to provide
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Agreement (PA) for its Weatherization Assistance Program (WAP), State Energy Program (SEP), and Energy ability of signatories to amend or terminate the agreement. DOE formally requested the ACHP comment on its , and EECBG in each state in lieu of renegotiating and amending each executed agreement. The prototype
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Publications - GMC 233 | Alaska Division of Geological & Geophysical
Tidal Datum Portal Climate and Cryosphere Hazards Coastal Hazards Program Guide to Geologic Hazards in geologic field program in Lower Cook Inlet, Alaska Authors: Roberts, Chuck, Coastal Science Laboratories publication sales page for more information. Bibliographic Reference Roberts, Chuck, Coastal Science
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Materials and Chemical Science and Technology | Research | NREL
Applications and Performance Developing high-efficiency crystalline PV, measuring PV cell/module performance Cells and Hydrogen Program Developing, integrating, and demonstrating hydrogen production/delivery /storage through core programs and EFRCs Point of Contact Bill Tumas MCST Research Advisors/Fellows Senior
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studies. Investigators must supply positive and negative controls. Current pricing for CIDR Program studies are for a minimum study size of 90 samples and increasing in multiples of 90. Please inquire for for the assay is included for CIDR Program studies. FFPE samples are supported for MethylationEPIC
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Facebook YouTube logo YouTube News & Announcements New FY 18 Nonprofit Security Grant Program (NSGP ) - Applications DUE June 11, 2018 6:00pm New Press Release - Newtok Awarded HMGP Grant for Erosion Threatened Homes Hazard Mitigation Grant Program (HMGP) Funds Availability Announcement Fact Sheet - Preparing for
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Mailman Segal Center for Human Development | NSU
Dean Jim & Jan Moran Family Center Village Collaborations Early Learning Programs About Early Learning Programs Family Center Preschool About Our Preschool Enrollment Family Center Infant & Toddler - Advanced ABA M.S. in Developmental Disabilities - ABA Non-Degree Seeking - ABA & Advanced ABA Autism
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Indiana | Solar Research | NREL
Incentive Programs Indiana exempts solar PV modules, racking, and inverter from state sales and use taxes . The entire solar generating system is exempt from property taxation. Utility Incentive Programs Utility Incentive Limitations Northern Indiana Public Service Company (Solar PV feed-in-tariff) $0.1564
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Assessing Conformity to Standards for Treatment Foster Care.
ERIC Educational Resources Information Center
Farmer, Elizabeth M. Z.; Burns, Barbara J.; Dubs, Melanie S.; Thompson, Shealy
2002-01-01
This study examined conformity to the Program Standards for Treatment Foster Care among 42 statewide programs. Findings suggest fair to good overall conformity, with considerable variation among programs. A discussion of methodological and substantive considerations for future research and evaluation using this approach is included. (Contains…
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Work Our Culture Community Connections Space Astronomy Summer Program Program Details Application Logo Expanding the Frontiers of Space Astronomy Mission Ad Boxes Collage of artist illustrations of
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Flu Surveillance: Department of Health
Worker Flu Vaccination Rates Programs Acute Infectious Disease Epidemiology, Center for Immunization Surviellance Healthcare Worker Flu Vaccination Rates Programs Acute Infectious Disease Epidemiology, Center for
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Search Search Home SH Reference Manual E19 Documentation Program Management Training/Drills Other Dataweb National Water Information System Database SH Reference Manual, E-19 Docs, Program Management
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Alternative Fuels Data Center: Deploying Alternative Fuel Vehicles in
Rochester, New York, Through the Congestion Mitigation and Air Quality Improvement Program in Rochester, New York, Through the Congestion Mitigation and Air Quality Improvement Program to someone by E -mail Share Alternative Fuels Data Center: Deploying Alternative Fuel Vehicles in Rochester, New York
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Preservation Officer, U.S. Forest Service. "This program has done a great deal to make the public more its vital role in heritage education through museum exhibits and programs, and incorporating award underscores the importance of our role in sharing the stories of Asian Pacific Americans for all
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Defense Threat Reduction Agency > Careers > Onboarding > Sponsor Program
critical role in the Onboarding Program. In addition to the traditional supervisory roles and explain expectations to ensure a smooth transition, and help you become successful in your new role. While will quickly become productive and effective in your new role. Reasonable Accommodations DTRA provides
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Recreational Water Illness (RWI) - Infectious Disease Epidemiology Program
& Prevention A Division of the Maine Department of Health and Human Services Contact EPI | News | Online services | Publications | Subject index Search EPI Search Maine CDC Home Health Topics A-Z Data /Reports For Health Care Providers For Businesses For Homeowners/Renters Divisions/Programs + A | - A
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History - National Site for the Regional IPM Centers
History of the Regional IPM Centers 2014 - Crop Protection and Pest Management Program (CPPM) Funding for eventually cut short to two years when the Crop and Pest Management Program replaced existing funding the word "Integrated" was inserted in the titles. Regional Integrated Pest Management
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Fermilab Science Education Office - Educators/Teachers
wide variety of professional development workshops, programs and educational resources. As an Illinois State Board of Education approved professional development provider, we use the Standards for Professional Learning in designing all of our programs. Read our e-Alert: January 2018ÂAugust 2018. For
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Center for Subsurface Sensing & Imaging Systems (CenSSIS)
Contact Us Home Wavelets ALERT Center PROTECT Program Gordon Engineering Leadership Program Center Members Simon Pitts awarded 2015 Gordon Prize ALERT Center Director, Michael B. Silevitch and Gordon Engineering Leadership Director, Simon Pitts have been awarded the 2015 Bernard M. Gordon Prize for Engineering Education
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Engineering Geology | Alaska Division of Geological & Geophysical Surveys
Tidal Datum Portal Climate and Cryosphere Hazards Coastal Hazards Program Guide to Geologic Hazards in Tidal Datum Portal Climate and Cryosphere Hazards Coastal Hazards Program Guide to Geologic Hazards in Highway and development of avalanche susceptibility and prediction models near Atigun Pass. Alaska coastal
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ACHP | Working Together to Build a More Inclusive Preservation Program
special interest to the AAPI community. Preserve America program connections, Chairman's Award for Achievement in Historic Preservation winners of special interest, Section 106 Success Stories, and partner East at Main Street, a special social media project "pinning" places of interest to the AAPI
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New Hampshire | Midmarket Solar Policies in the United States | Solar
implemented. New Hampshire Public Utilities Commission's (NHPUC) administers a rebate program for commercial Administrator Incentive Commercial & Industrial Solar Incentive Program New Hampshire Public Utilities $0.25/W rebate for residential systems $0.25/W rebate for commercial/government systems Capped at $1,375
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Department of Navy FY17 Budget: Delivering Options, Assuring Allies,
Services program and Surface Electronic Warfare Improvement Program. Hard Choices This fiscal environment requires each Service to make hard choices in prioritizing their budget, examining every account to sustain advantage, accelerate learning and strengthen our team. In making hard choices and allocating risk
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The Ministry of Commerce and Industry
Commerce Minister Participates In The Celebration Of The World Intellectual Property Day Program Deputy Commerce Minister Participates In The Celebration Of The World Intellectual Property Day Program Hon the World Trade Organization at the e-Commerce Week Commerce Minister meets with the Director-General
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Capital Construction Fund Program :: Office of Management and Budget
vessels with before-tax, rather than after-tax dollars. Under the CCF Program, the amount accumulated by deferring tax on fishing income, when used to help pay for a vessel project, represents the time value of , to be applicable to any given tax year, a CCF agreement must be executed and entered on or before the
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7 CFR 1945.35 - Special EM loan training.
Code of Federal Regulations, 2010 CFR
2010-01-01
...) PROGRAM REGULATIONS (CONTINUED) EMERGENCY Disaster Assistance-General § 1945.35 Special EM loan training... workshop and a test. (c) Objective. The basic objective of this training program is to keep State and... employees in administering the EM loan program. (d) Comprehensive EM loan training package. A comprehensive...
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Work Our Culture Community Connections Space Astronomy Summer Program Program Details Application Ophiuchi Dark Cloud STScI Logo Expanding the Frontiers of Space Astronomy Mission Ad Boxes Collage of
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Virginia Natural Heritage Program
Heritage About Natural Heritage Overview, Mission Natural Heritage Inventory Community Ecology Program ) | Strategic Plan (PDF) | Executive Progress Report (PDF) | Code of Ethics (PDF) Your browser does not support
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Search Search Home SH Reference Manual E19 Documentation Program Management Training/Drills Other River and Lake Summary (RVD) SH Reference Manual, E-19 Docs, Program Management, Training/Drills, Other
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Morini, F; Knippenberg, S; Deleuze, M S; Hajgató, B
2010-04-01
The main purpose of the present work is to simulate from many-body quantum mechanical calculations the results of experimental studies of the valence electronic structure of n-hexane employing photoelectron spectroscopy (PES) and electron momentum spectroscopy (EMS). This study is based on calculations of the valence ionization spectra and spherically averaged (e, 2e) electron momentum distributions for each known conformer by means of one-particle Green's function [1p-GF] theory along with the third-order algebraic diagrammatic construction [ADC(3)] scheme and using Kohn-Sham orbitals derived from DFT calculations employing the Becke 3-parameters Lee-Yang-Parr (B3LYP) functional as approximations to Dyson orbitals. A first thermostatistical analysis of these spectra and momentum distributions employs recent estimations at the W1h level of conformational energy differences, by Gruzman et al. [J. Phys. Chem. A 2009, 113, 11974], and of correspondingly obtained conformer weights using MP2 geometrical, vibrational, and rotational data in thermostatistical calculations of partition functions beyond the level of the rigid rotor-harmonic oscillator approximation. Comparison is made with the results of a focal point analysis of these energy differences using this time B3LYP geometries and the corresponding vibrational and rotational partition functions in the thermostatistical analysis. Large differences are observed between these two thermochemical models, especially because of strong variations in the contributions of hindered rotations to relative entropies. In contrast, the individual ionization spectra or momentum profiles are almost insensitive to the employed geometry. This study confirms the great sensitivity of valence ionization bands and (e, 2e) momentum distributions on the molecular conformation and sheds further light on spectral fingerprints of through-space methylenic hyperconjugation, in both PES and EMS experiments.
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quality nonattainment and maintenance areas. The VALE Program provides funding through the Airport quality improvements. For more information, see the VALE Program website. (Reference 49 U.S. Code 47139
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Optical Astronomy Observatories (NOAO), located in La Serena, Chile, offers 10 week Undergraduate Research REU/PIA English/Spanish Astronomy Dictionary REU/PIA Current and Previous Programs CTIO REU/PIA Alumni
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ACHP | Federal Agency Historic Preservation Programs and Officers
Working with Section 106 Federal, State, & Tribal Programs Training & Education Publications foster conditions under which modern society and prehistoric and historic resources can exist in
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Office of the Under Secretary of Defense (Comptroller)
Estimates for FY 2019 (Green Book) PDF icon Excel icon (Zip File) Operations and Maintenance Overview Operation and Maintenance Overview PDF icon Budget Documents Military Personnel Programs (M-1) PDF icon Excel icon - Budget Appendix Display (M-1) Excel icon Operation and Maintenance Programs (O-1) PDF icon
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Energy Systems Integration News | Energy Systems Integration Facility |
Control of Power Electronics in AC Systems and Microgrids. These courses will be part of a Professional Master's Program in Power Electronics offered through the university. Get more information on the program Scheme for the Voltage Control of a DFIG-Based Wind Power Plant, IEEE Transactions on Power Electronics
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sexual assault « Coast Guard All Hands
accountability Some potentially positive news from the Sexual Assault Prevention and Response (SAPR) program: The . Coast Guard Sexual Assault Prevention and Response program logo. U.S. Coast Guard illustration by Petty Sexual Assault Prevention and Response Office, and U.S. Coast Guard Rear Adm. Erica Schwartz, director of
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Commuter Programs | Climate Neutral Research Campuses | NREL
. Offering a guaranteed ride home option that provides free taxi or shuttle rides home in cases of emergency with local public transportation systems and other organizations. Program features include: Free public transportation on campus for faculty, staff, and first-year students. Public transportation is free to all
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DUF6 Management and Uses DUF6 Conversion EIS Documents News FAQs Internet Resources Glossary Home  Depleted UF6 Conversion EIS or the Depleted UF6 Management Program web site. Your questions or comments site is to inform and involve the public in the Depleted UF6 Management Program, including the Depleted
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Florida Healthy Beaches Program | Florida Department of Health
Phone Numbers WIC Income Guidelines How WIC Works WIC Foods Food Vendors Health Care Providers Nutrition Materials What is WIC? WIC is a federally funded nutrition program for Women, Infants, and Children. WIC provides the following at no cost: healthy foods, nutrition education and counseling, breastfeeding support
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Renewable Energy Rebates | State, Local, and Tribal Governments | NREL
for renewable energy credits. Rebate programs may be most effective when designed and implemented as reviewed carefully when considering the correct rebate amount. These variables can greatly affect how technology without a rebate. In states where market activity is moderate or high prior to rebate program
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Program Alternatives - 36 CFR § 800.14
implementation of a particular agency program or the resolution of adverse effects from complex projects or and the potential effects from the undertakings must be foreseeable and likely to be minimal or not undertakings, effects, historic properties, or treatment options. Standard treatments carry the ACHP's explicit
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ACHP | Meet Maia Wikler, 2016 Intern at the Advisory Council on Historic
historic preservation careers, and is also developing recommendations for integrating the articles in the and in Brazil as well as developing community engagement programs, I was very interested in pursuing the connection of youth empowerment and cultural preservation through programming. The opportunity to
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Alternative Fuel Vehicle Conversion Grant Program The Ohio Environmental Protection Agency will administer a one-time, $5 million grant program to replace or convert Class 7 and Class 8 diesel or gasoline time. Maximum grant awards will be 50% of the fuel components of the new vehicle or 50% of the cost of
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ACHP | Working Together to Build a More Inclusive Preservation Program
Working with Section 106 Federal, State, & Tribal Programs Training & Education Publications should serve as a museum of one period in time but as a laboratory of its transformation over the years transformation of Cleveland's downtown from a singularly business-centric to a multi-use live/work/play
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Fermilab Friends for Science Education | Programs | Past Donors
the U.S. Trust Company of New York AT&T Bell Laboratories Aurora Foundation, The Batavia Schools Teachers of Mathematics Illinois Department of Natural Resources Illinois State Board of Education Science Literacy Program Joyce Foundation, The Kane County Board of Education Kane County Riverboat Fund Marmon
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available through the RFS Program website. Section 203 Feedstock Impact Study of RFS DOE Requires DOE to work with NAS to conduct a study and issue a report on the impacts of the RFS program, including , USDA Requires a study to report on the current and future environmental and resource conservation
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STATEMAP - Program information | Alaska Division of Geological &
Observatory (AVO) Mineral Resources Alaska's Mineral Industry Reports AKGeology.info Rare Earth Elements critical Earth science problems. STATEMAP products Alaska benefits of NCGMP's STATEMAP program Summary map
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Scout Programs For Boy Scouts, Webelos, and Girl Scouts
Programs | Science Adventures | Calendar | Registration | About | Contact | FAQ | Fermilab Friends - Fermilab Friends - Fermilab Home Fermilab Office of Education & Public Outreach Fermilab MS 226 Box 500
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Reintegration Program DMDC Defense Manpower Data Center Enterprise Training DMDC Transition Assistance Program Interest (CoI). This unclassified short course is a stand-alone, 100% online, web-based course that uses
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Equal Employment Opportunity Program, Division of Personnel and Labor
and organizations. Equal Employment Opportunity and Affirmative Action In conjunction with the EEO and Affirmative Action. The EEO Program Manager coordinates, reviews, or determines issues
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75 FR 66245 - HUD Programs: Violence Against Women Act Conforming Amendments
Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-27
...: Violence Against Women Act Conforming Amendments; Final Rule #0;#0;Federal Register / Vol. 75 , No. 207...-F-02] RIN 2577-AC65 HUD Programs: Violence Against Women Act Conforming Amendments AGENCY: Office of... rule that conformed HUD's regulations to those provisions of the Violence Against Women Act (VAWA), as...
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administers the Ethanol Infrastructure Incentive Program, providing grants to offset the cost of installing Ethanol Infrastructure Incentive Program website. (Reference South Dakota Statutes 10-47B-162 and 10-47B
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. Northern Command Speakers Program The U.S. Northern Command Speaker's Program works to increase face-to -face contact with our public to help build and sustain public understanding of our command missions and
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About Us - Director's Office | Alaska Division of Geological & Geophysical
, state, federal, and private agencies; seeks out and encourages cooperative geologic programs of value to local, state, federal, and private agencies; seeking out and encouraging cooperative geologic programs
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Vermont | Midmarket Solar Policies in the United State | Solar Research |
/Agricultural Energy Loan Program Vermont Economic Development Authority Maximum loan of $2 million may be Development Authority: Agricultural Energy Loan Program Vermont Economic Development Authority: Small Business
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Biofuels Infrastructure Partnership (BIP) grant program. The BIP program works with retailers and state and eligible applicants in the following amounts: Infrastructure Grant Amount E15 Pumps 50% of the costs of
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About STIP | OSTI, US Dept of Energy Office of Scientific and Technical
Information Skip to main content Scientific and Technical Information Program The home of the U.S. Department of Energy's Scientific and Technical Information Program (STIP) Here you will find through scientific and technical information (STI), a key outcome of DOE R&D and other activities
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Contact Us | OSTI, US Dept of Energy Office of Scientific and Technical
Information Skip to main content Scientific and Technical Information Program The home of the U.S. Department of Energy's Scientific and Technical Information Program (STIP) Here you will find MAIL TO: U.S. Department of Energy Office of Scientific and Technical Information ATTN: STIP P.O. Box
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Meshkat, Nazanin; Teklu, Sisay; Hunchak, Cheryl
2018-04-06
To design and implement an emergency medicine (EM) postgraduate training curriculum to support the establishment of the first EM residency program at Addis Ababa University (AAU). In response to the Ethiopian Federal Ministry of Health mandate to develop EM services in Ethiopia, University of Toronto EM faculty were invited to develop and deliver EM content and expertise for the first EM postgraduate residency training program at AAU. The Toronto Addis Ababa Academic Collaboration-EM (TAAAC-EM) used five steps of a six-step approach to guide curriculum development and implementation: 1. Problem identification and general needs assessment, 2. Targeted needs assessment using indirect methods (interviews and site visits of the learners and learning environment), 3. Defining goals and objectives, 4. Choosing educational strategies and curriculum map development and 5. The needs assessment identified a learning environment with appropriate, though limited, resources for the implementation of an EM residency program. A lack of educational activities geared towards EM practice was identified, specifically of active learning techniques (ALTs) such as bedside teaching, simulation and procedural teaching. A curriculum map was devised to supplement the AAU EM residency program curriculum. The TAAAC-EM curriculum was divided into three distinct streams: clinical, clinical epidemiology and EM administration. The clinical sessions were divided into didactic and ALTs including practical/procedural and simulation sessions, and bedside teaching was given a strong emphasis. Implementation is currently in its seventh year, with continuous monitoring and revisions of the curriculum to meet evolving needs. We have outlined the design and implementation of the TAAAC-EM curriculum; an evaluation of this curriculum is currently underway. As EM spreads as a specialty throughout Africa and other resource-limited regions, this model can serve as a working guide for similar bi-institutional educational partnerships seeking to develop novel EM postgraduate training programs.
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Presentations - Delaney, P.R. and others, 2008 | Alaska Division of
, northeastern Alaska (poster): AAPG Abstracts with Programs, San Antonio, Texas Authors: Delaney, P.R., Loveland thrust belt, Kavik River area, northeastern Alaska (poster): AAPG Abstracts with Programs, San Antonio
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Alternative Fuels Data Center: Maps and Data
emissions comparison of heavy duty vehicles as captured by the Clean Cities Program. Last update February emissions comparison of light duty vehicles as captured by the Clean Cities Program. Last update February
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Alternative Fuels Data Center: Maps and Data
gas emissions comparison of heavy duty vehicles as captured by the Clean Cities Program. Last update gas emissions comparison of light duty vehicles as captured by the Clean Cities Program. Last update
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Ross, Elliot M; Harper, Stephen A; Cunningham, Cord; Walrath, Benjamin D; DeMers, Gerard; Kharod, Chetan U
2017-03-01
As part of a Military Emergency Medical Services (EMS) system process improvement initiative, the authors sought to objectively evaluate the U.S. military EMS system for the island of Okinawa. They applied a program evaluation tool currently utilized by the U.S. National Park Service (NPS). A comprehensive needs assessment was conducted to evaluate the current Military EMS system in Okinawa, Japan. The NPS EMS Program Audit Worksheet was used to get an overall "score" of our assessment. After all the data had been collected, a joint committee of Military EMS physicians reviewed the findings and made formal recommendations. From 2011 to 2014, U.S. military EMS on Okinawa averaged 1,345 ± 137 patient transports annually. An advanced life support (ALS) provider would have been dispatched on 558 EMS runs (38%) based on chief complaint in 2014 had they been available. Over 36,000 man-hours were expended during this period to provide National Registry Emergency Medical Technician (EMT)-accredited instruction to certify 141 Navy Corpsman as EMT Basics. The NPS EMS Program Audit Worksheet was used and the program scored a total of 31, suggesting the program is well planned and operating within standards. This evaluation of the Military EMS system on Okinawa using the NPS program assessment and audit worksheet demonstrates the NPS evaluation instruments may offer a useful assessment tool for the evaluation of Military EMS systems. Reprint & Copyright © 2017 Association of Military Surgeons of the U.S.
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Energy Education Energy Education Learn how NREL's Workforce Development and Education Programs lectures at NREL's Education Center. Energy Education for Students 4th-12th Grades Energy Education
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Alternative Fuels Data Center: Idle Reduction Programs at Tennessee Schools
quality and reduce oil consumption," Keel said. But the impact is being felt inside the classroom too program is drawing interest, in part because the area has air quality challenges. "We're in a valley Jake Tisinger said that Knoxville has made great strides in improving its air quality, and the Idle
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FitEM2EM—Tools for Low Resolution Study of Macromolecular Assembly and Dynamics
Frankenstein, Ziv; Sperling, Joseph; Sperling, Ruth; Eisenstein, Miriam
2008-01-01
Studies of the structure and dynamics of macromolecular assemblies often involve comparison of low resolution models obtained using different techniques such as electron microscopy or atomic force microscopy. We present new computational tools for comparing (matching) and docking of low resolution structures, based on shape complementarity. The matched or docked objects are represented by three dimensional grids where the value of each grid point depends on its position with regard to the interior, surface or exterior of the object. The grids are correlated using fast Fourier transformations producing either matches of related objects or docking models depending on the details of the grid representations. The procedures incorporate thickening and smoothing of the surfaces of the objects which effectively compensates for differences in the resolution of the matched/docked objects, circumventing the need for resolution modification. The presented matching tool FitEM2EMin successfully fitted electron microscopy structures obtained at different resolutions, different conformers of the same structure and partial structures, ranking correct matches at the top in every case. The differences between the grid representations of the matched objects can be used to study conformation differences or to characterize the size and shape of substructures. The presented low-to-low docking tool FitEM2EMout ranked the expected models at the top. PMID:18974836
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CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel
James, Zachary M.; Borst, Andrew J.; Haitin, Yoni; Frenz, Brandon; DiMaio, Frank; Zagotta, William N.; Veesler, David
2017-01-01
Cyclic nucleotide-gated (CNG) and hyperpolarization-activated cyclic nucleotide-regulated (HCN) ion channels play crucial physiological roles in phototransduction, olfaction, and cardiac pace making. These channels are characterized by the presence of a carboxyl-terminal cyclic nucleotide-binding domain (CNBD) that connects to the channel pore via a C-linker domain. Although cyclic nucleotide binding has been shown to promote CNG and HCN channel opening, the precise mechanism underlying gating remains poorly understood. Here we used cryoEM to determine the structure of the intact LliK CNG channel isolated from Leptospira licerasiae—which shares sequence similarity to eukaryotic CNG and HCN channels—in the presence of a saturating concentration of cAMP. A short S4–S5 linker connects nearby voltage-sensing and pore domains to produce a non–domain-swapped transmembrane architecture, which appears to be a hallmark of this channel family. We also observe major conformational changes of the LliK C-linkers and CNBDs relative to the crystal structures of isolated C-linker/CNBD fragments and the cryoEM structures of related CNG, HCN, and KCNH channels. The conformation of our LliK structure may represent a functional state of this channel family not captured in previous studies. PMID:28396445
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Contact Us - Division of Mining, Land, and Water
Lands Coal Regulatory Program Large Mine Permits Mineral Property and Rights Mining Index Land Coal Regulatory Program 550 W. 7th Ave., Suite 900D Anchorage, AK 99501-3577 Phone: (907) 269-8650 Fax
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NREL: SMARTS - Register for SMARTS
provided free of charge to the User under the conditions that: The User recognizes that the Program is the Author's preliminary acceptance only if it is distributed free of charge. The Program is not to be used for
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Code of Federal Regulations, 2014 CFR
2014-01-01
... accreditation body which satisfies the established requirements. (b) NIST operates the NVCASE program as follows: (1) Conformity level: Under this program NIST accepts requests for evaluations of U.S. bodies involved in activities related to conformity assessment. NIST does not perform conformity assessments as...
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Code of Federal Regulations, 2012 CFR
2012-01-01
... accreditation body which satisfies the established requirements. (b) NIST operates the NVCASE program as follows: (1) Conformity level: Under this program NIST accepts requests for evaluations of U.S. bodies involved in activities related to conformity assessment. NIST does not perform conformity assessments as...
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Code of Federal Regulations, 2011 CFR
2011-01-01
... accreditation body which satisfies the established requirements. (b) NIST operates the NVCASE program as follows: (1) Conformity level: Under this program NIST accepts requests for evaluations of U.S. bodies involved in activities related to conformity assessment. NIST does not perform conformity assessments as...
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Code of Federal Regulations, 2010 CFR
2010-01-01
... accreditation body which satisfies the established requirements. (b) NIST operates the NVCASE program as follows: (1) Conformity level: Under this program NIST accepts requests for evaluations of U.S. bodies involved in activities related to conformity assessment. NIST does not perform conformity assessments as...
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Code of Federal Regulations, 2013 CFR
2013-01-01
... accreditation body which satisfies the established requirements. (b) NIST operates the NVCASE program as follows: (1) Conformity level: Under this program NIST accepts requests for evaluations of U.S. bodies involved in activities related to conformity assessment. NIST does not perform conformity assessments as...
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NOAA Office of Exploration and Research > Education > Materials
2014 Funding Opportunities Contact Us Program Review Review Panel Final Report Review Team Documents Review Review Panel Final Report Review Team Documents Presentations Supporting Documents Guiding
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F-35 program accelerating, at 'pivot point,' program chief tells Congress >
the CMSAF The Book Speeches Archive Former AF Top 3 Viewpoints and Speeches Air Force Warrior Games Games Portraits in Courage Portraits In Courage Vol. I Portraits In Courage Vol. II Portraits In Courage
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DOT National Transportation Integrated Search
1996-06-01
The Clean Air Act Amendments (CAAA) of 1990 required emissions reductions in : nonattainment areas. The CAAA contains conformity provisions requiring : transportation plans and programs to conform to air quality plans. Based on the : documented analy...
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Videos | Argonne National Laboratory
science --Agent-based modeling --Applied mathematics --Artificial intelligence --Cloud computing management -Intelligence & counterterrorrism -Vulnerability assessment -Sensors & detectors Programs
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A Study of Wind Turbine Comprehensive Operational Assessment Model Based on EM-PCA Algorithm
NASA Astrophysics Data System (ADS)
Zhou, Minqiang; Xu, Bin; Zhan, Yangyan; Ren, Danyuan; Liu, Dexing
2018-01-01
To assess wind turbine performance accurately and provide theoretical basis for wind farm management, a hybrid assessment model based on Entropy Method and Principle Component Analysis (EM-PCA) was established, which took most factors of operational performance into consideration and reach to a comprehensive result. To verify the model, six wind turbines were chosen as the research objects, the ranking obtained by the method proposed in the paper were 4#>6#>1#>5#>2#>3#, which are completely in conformity with the theoretical ranking, which indicates that the reliability and effectiveness of the EM-PCA method are high. The method could give guidance for processing unit state comparison among different units and launching wind farm operational assessment.
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NOAA: Primary GOES-R instrument cleared for installation onto spacecraft
: NOAA-NASA GOES-R Program Office) In early 2014 the ABI will be shipped from its developer, Exelis, in performance of power grids. NOAA manages the GOES-R Series program through an integrated NOAA-NASA office
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U.S. Pacific Command > Resources > Travel Requirements > ATFP FAQs
receiving errors when I try to access the TT/IATP program; what is causing this and how do I gain access to the program? 7. How will I know when/if my APACS request has been approved? 8. Do I need Theater and Country Clearance approval if I'm traveling on leave? 9. If I work in the American Embassy (USDAO/JUSMAG
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Alternatives to Traditional EMS Dispatch and Transport: A Scoping Review of Reported Outcomes.
Jensen, Jan L; Carter, Alix J E; Rose, Jennifer; Visintini, Sarah; Bourdon, Emmanuelle; Brown, Ryan; McVey, Jennifer; Travers, Andrew H
2015-09-01
Emergency medical services (EMS) programs, which provide an alternative to traditional EMS dispatch or transport to the emergency department (ED), are becoming widely implemented. This scoping review identified and catalogued all outcomes used to measure such alternative EMS programs. Data Source Broad systematized bibliographic and grey literature searches were conducted. Study Selection Inclusion criteria were 911 callers/EMS patients, reported on alternatives to traditional EMS dispatch OR traditional EMS transport to the ED, and reported an outcome measure. Data Extraction The reports were categorized as either alternative to dispatch or to EMS transport, and outcome measures were categorized and described. Data Synthesis The bibliographic search retrieved 13,215 records, of which 34 articles met the inclusion criteria, with an additional 10 added from reference list hand-searching (n=44 included). In the grey literature search, 31 websites were identified, from which four met criteria and were retrieved (n=4 included). Fifteen reports (16 studies) described alternatives to EMS dispatch, and 33 reports described alternatives to EMS transport. The most common outcomes reported in the alternatives to EMS dispatch reports were service utilization and decision accuracy. Twenty-four different specific outcomes were reported. The most common outcomes reported in the alternatives to EMS transport reports were service utilization and safety, and 50 different specific outcomes were reported. Numerous outcome measures were identified in reports of alternative EMS programs, which were catalogued and described. Researchers and program leaders should achieve consensus on uniform outcome measures, to allow benchmarking and improve comparison across programs.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Mountassif, Driss; Fabre, Lucien; Zaid, Younes
Single amino acid mutations in valosin containing protein (VCP/p97), a highly conserved member of the ATPases associated with diverse cellular activities (AAA) family of ATPases has been linked to a severe degenerative disease affecting brain, muscle and bone tissue. Previous studies have demonstrated the role of VCP mutations in altering the ATPase activity of the D2 ring; however the structural consequences of these mutations remain unclear. In this study, we report the three-dimensional (3D) map of the pathogenic VCP variant, R155P, as revealed by single-particle Cryo-Electron Microscopy (EM) analysis at 14 Å resolution. We show that the N-terminal R155P mutation inducesmore » a large structural reorganisation of the D2 ATPase ring. Results from docking studies using crystal structure data of available wild-type VCP in the EM density maps indicate that the major difference is localized at the interface between two protomers within the D2 ring. Consistent with a conformational change, the VCP R155P variant shifted the isoelectric point of the protein and reduced its interaction with its well-characterized cofactor, nuclear protein localization-4 (Npl4). Together, our results demonstrate that a single amino acid substitution in the N-terminal domain can relay long-range conformational changes to the distal D2 ATPase ring. Our results provide the first structural clues of how VCP mutations may influence the activity and function of the D2 ATPase ring. - Highlights: • p97{sub R155P} and p97{sub A232E} decrease the ability of p97 to bind to its co-factor Npl4. • p97{sub R155P} has a different isoelectric point than that of p97{sub R95G}, p97{sub A232E} and p97{sub WT}. • Mutation R155P changes principally the conformation of the D2 ring. • Mutation R155P modifies the interface between two protomers within the D2 ring.« less
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Department of Navy Chief Information Officer
(6) Freedom of Information Act (29) IT Investment Management (47) Records Management (37 Management and Knowledge Management programs. DON CIO Information About the DON CIO Website Accessibility this website is to facilitate effective information flow about information management/information
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of residential solar PV markets. Eric leads the lab's solar data partnerships program. Eric's current green power market research. Research Interests Economic analysis, econometrics, distributed solar PV . Ardani, R. Margolis. 2018. Solar plus: Optimization of distributed solar PV through battery storage and
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Process Development Unit. NREL's Thermal and Catalytic Process Development Unit can process 1/2 ton per biomass to fuels and chemicals Affiliated Research Programs Thermochemical Process Integration, Scale-Up
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atomic layer deposition for applications. He also manages the majority of X-ray characterization equipment at NREL, specifically X-ray diffraction and X-ray fluorescence instrumentation. Additionally, he for EERE's Hydrogen Storage program. He is also an expert in X-ray diffraction and X-ray fluorescence
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NOAA Office of Exploration and Research > About OER > Program Review >
OER Overview Organization Guiding Documents Organizational Structure Map of Staff and Affiliate Overview Organization Guiding Documents Organizational Structure Map of Staff and Affiliate Locations
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Smith Photo of Brian Smith Brian Smith Laboratory Program Manager II - Mechanical Engineering Brian.Smith@nrel.gov | 303-384-6911 Brian Smith is Partnership Manager for the NWTC and focuses on portfolio
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NOAA Office of Exploration and Research > Home
2014 Funding Opportunities Contact Us Program Review Review Panel Final Report Review Team Documents Review Review Panel Final Report Review Team Documents Presentations Supporting Documents Guiding the NOAA Science Advisory Board, a thirteen-member Review Panel conducted the first-ever formal
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Related Links & Resources Access and Applications Access Applications Example Applications Project Us -Privacy Policy -Site Map Search You are here: CIDR>Access and Applications> Deadlines NIH Program must submit an electronic application to NIH. Applications are continuously accepted and are
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Plug-In Electric Vehicle (PEV) Discounts - Mass Energy Mass Energy's Drive Green with Mass Energy discount program is available to all consumers, including those that are not in Mass Energy's service Drive Green with Mass Energy
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NREL: Renewable Resource Data Center - Geothermal Resource Information
Energy's Office of Energy Efficiency and Renewable Energy Geothermal Technologies Program. Its collection , and thermal springs. View NREL's Geothermal resource maps as well as maps for other renewable energy Geothermal Resource Information Geothermal Prospector Start exploring U.S. geothermal resources
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Structures of closed and open conformations of dimeric human ATM
Baretić, Domagoj; Pollard, Hannah K.; Fisher, David I.; Johnson, Christopher M.; Santhanam, Balaji; Truman, Caroline M.; Kouba, Tomas; Fersht, Alan R.; Phillips, Christopher; Williams, Roger L.
2017-01-01
ATM (ataxia-telangiectasia mutated) is a phosphatidylinositol 3-kinase–related protein kinase (PIKK) best known for its role in DNA damage response. ATM also functions in oxidative stress response, insulin signaling, and neurogenesis. Our electron cryomicroscopy (cryo-EM) suggests that human ATM is in a dynamic equilibrium between closed and open dimers. In the closed state, the PIKK regulatory domain blocks the peptide substrate–binding site, suggesting that this conformation may represent an inactive or basally active enzyme. The active site is held in this closed conformation by interaction with a long helical hairpin in the TRD3 (tetratricopeptide repeats domain 3) domain of the symmetry-related molecule. The open dimer has two protomers with only a limited contact interface, and it lacks the intermolecular interactions that block the peptide-binding site in the closed dimer. This suggests that the open conformation may be more active. The ATM structure shows the detailed topology of the regulator-interacting N-terminal helical solenoid. The ATM conformational dynamics shown by the structures represent an important step in understanding the enzyme regulation. PMID:28508083
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Characteristics of Emergency Medicine Residency Programs in Colombia
Patiño, Andrés; Alcalde, Victor; Gutierrez, Camilo; Romero, Mauricio Garcia; Carrillo, Atilio Moreno; Vargas, Luis E.; Vallejo, Carlos E.; Zarama, Virginia; Mora Rodriguez, José L.; Bustos, Yury; Granada, Juliana; Aguiar, Leonar G.; Menéndez, Salvador; Cohen, Jorge I.; Saavedra, Miguel A.; Rodriguez, Juan M.; Roldan, Tatiana; Arbelaez, Christian
2017-01-01
Introduction Emergency medicine (EM) is in different stages of development around the world. Colombia has made significant strides in EM development in the last two decades and recognized it as a medical specialty in 2005. The country now has seven EM residency programs: three in the capital city of Bogotá, two in Medellin, one in Manizales, and one in Cali. The seven residency programs are in different stages of maturity, with the oldest founded 20 years ago and two founded in the last two years. The objective of this study was to characterize these seven residency programs. Methods We conducted semi-structured interviews with faculty and residents from all the existing programs in 2013–2016. Topics included program characteristics and curricula. Results Colombian EM residencies are three-year programs, with the exception of one four-year program. Programs accept 3–10 applicants yearly. Only one program has free tuition and the rest charge tuition. The number of EM faculty ranges from 2–15. EM rotation requirements range from 11–33% of total clinical time. One program does not have a pediatric rotation. The other programs require 1–2 months of pediatrics or pediatric EM. Critical care requirements range from 4–7 months. Other common rotations include anesthesia, general surgery, internal medicine, obstetrics, gynecology, orthopedics, ophthalmology, radiology, toxicology, psychiatry, neurology, cardiology, pulmonology, and trauma. All programs offer 4–6 hours of protected didactic time each week. Some programs require Advanced Cardiac Life Support, Pediatric Advanced Life Support and Advanced Trauma Life Support, with some programs providing these trainings in-house or subsidizing the cost. Most programs require one research project for graduation. Resident evaluations consist of written tests and oral exams several times per year. Point-of-care ultrasound training is provided in four of the seven programs. Conclusion As emergency medicine continues to develop in Colombia, more residency programs are expected to emerge. Faculty development and sustainability of academic pursuits will be critically important. In the long term, the specialty will need to move toward certifying board exams and professional development through a national EM organization to promote standardization across programs. PMID:29085546
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Characteristics of Emergency Medicine Residency Programs in Colombia.
Patiño, Andrés; Alcalde, Victor; Gutierrez, Camilo; Romero, Mauricio Garcia; Carrillo, Atilio Moreno; Vargas, Luis E; Vallejo, Carlos E; Zarama, Virginia; Mora Rodriguez, José L; Bustos, Yury; Granada, Juliana; Aguiar, Leonar G; Menéndez, Salvador; Cohen, Jorge I; Saavedra, Miguel A; Rodriguez, Juan M; Roldan, Tatiana; Arbelaez, Christian
2017-10-01
Emergency medicine (EM) is in different stages of development around the world. Colombia has made significant strides in EM development in the last two decades and recognized it as a medical specialty in 2005. The country now has seven EM residency programs: three in the capital city of Bogotá, two in Medellin, one in Manizales, and one in Cali. The seven residency programs are in different stages of maturity, with the oldest founded 20 years ago and two founded in the last two years. The objective of this study was to characterize these seven residency programs. We conducted semi-structured interviews with faculty and residents from all the existing programs in 2013-2016. Topics included program characteristics and curricula. Colombian EM residencies are three-year programs, with the exception of one four-year program. Programs accept 3-10 applicants yearly. Only one program has free tuition and the rest charge tuition. The number of EM faculty ranges from 2-15. EM rotation requirements range from 11-33% of total clinical time. One program does not have a pediatric rotation. The other programs require 1-2 months of pediatrics or pediatric EM. Critical care requirements range from 4-7 months. Other common rotations include anesthesia, general surgery, internal medicine, obstetrics, gynecology, orthopedics, ophthalmology, radiology, toxicology, psychiatry, neurology, cardiology, pulmonology, and trauma. All programs offer 4-6 hours of protected didactic time each week. Some programs require Advanced Cardiac Life Support, Pediatric Advanced Life Support and Advanced Trauma Life Support, with some programs providing these trainings in-house or subsidizing the cost. Most programs require one research project for graduation. Resident evaluations consist of written tests and oral exams several times per year. Point-of-care ultrasound training is provided in four of the seven programs. As emergency medicine continues to develop in Colombia, more residency programs are expected to emerge. Faculty development and sustainability of academic pursuits will be critically important. In the long term, the specialty will need to move toward certifying board exams and professional development through a national EM organization to promote standardization across programs.
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Hurricane Research Division of AOML/NOAA
Statement The mission of NOAA's Hurricane Research Division (HRD) is to advance the understanding and Learn More. What's New Links of Interest Hurricane Field Program Current Hurricane Data Hurricane FAQ
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Family Programs Dean of Students Scholarships & Financial Aid Employee, Alumni, & Other Resources Education Georgia Tech Online Academic Calendar Admissions Prospective Students Admissions Overview roots extend worldwide, creating international business connections and giving students unique research
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Sandia National Laboratories: Locations: Kauai Test Facility
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NOAA Office of Exploration and Research > About OER > Program Review >
About OER Overview Organization Guiding Documents Organizational Structure Map of Staff and Affiliate About OER Overview Organization Guiding Documents Organizational Structure Map of Staff and Affiliate
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Sandia National Laboratories: News
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Sandia National Laboratories: Research
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Research/Teaching Assistant, Stanford University, Stanford, CA (2007-2014) Research Intern, Battelle Analysis Center. Areas of Expertise Energy systems modeling and analysis Linear programming Research Memorial Institute, Columbus, OH (2006-2007) Research Assistant, The Ohio State University, Columbus, OH
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, Community, and Economic Development Small Business Assistance Center More Business Links » Visitor Visiting (RUBA) Program Business Resources Department of Community and Economic Development Div. of Corporations Anchorage Economic Development Corporation Fairbanks Economic Development Corporation Juneau Economic
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ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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Distributed Wind Research | Wind | NREL
evaluation, and improve wind turbine and wind power plant performance. A photo of a snowy road leading to a single wind turbine surrounded by snow-covered pine trees against blue sky. Capabilities NREL's power plant and small wind turbine development. Algorithms and programs exist for simulating, designing
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DGIC Interconnection Insights | Distributed Generation Interconnection
Power Association (SEPA), produced a webinar Utility Participation in the Roof Top Solar PV Market with ). These leaders are pioneering utility-owned rooftop solar programs to broaden the reach of solar PV utility hired solar PV developers who, representing CPS Energy, will install, own, and maintain solar
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The New Jersey Water Resources Research Institute at Rutgers NJAES
Rutgers New Jersey Agricultural Experiment Station [The New Jersey Water Resources Research wetland Program Areas The New Jersey Water Resources Research Institute (NJWRRI) is a federally-funded water in the state. Its mission is to: sponsor research on all aspects of water quality, water quantity
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Sandia National Laboratories: Employee & Retiree Resources: Emergency
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Sandia National Laboratories: Research: Laboratory Directed Research &
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Sandia National Laboratories: Visiting Research Scholars
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Sandia National Laboratories: News: Videos
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Sandia National Laboratories: Cooperative Research and Development
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Sandia National Laboratories: Research: Bioscience
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Sandia National Laboratories: Integrated Military Systems
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Electron Microscopic Visualization of Protein Assemblies on Flattened DNA Origami.
Mallik, Leena; Dhakal, Soma; Nichols, Joseph; Mahoney, Jacob; Dosey, Anne M; Jiang, Shuoxing; Sunahara, Roger K; Skiniotis, Georgios; Walter, Nils G
2015-07-28
DNA provides an ideal substrate for the engineering of versatile nanostructures due to its reliable Watson-Crick base pairing and well-characterized conformation. One of the most promising applications of DNA nanostructures arises from the site-directed spatial arrangement with nanometer precision of guest components such as proteins, metal nanoparticles, and small molecules. Two-dimensional DNA origami architectures, in particular, offer a simple design, high yield of assembly, and large surface area for use as a nanoplatform. However, such single-layer DNA origami were recently found to be structurally polymorphous due to their high flexibility, leading to the development of conformationally restrained multilayered origami that lack some of the advantages of the single-layer designs. Here we monitored single-layer DNA origami by transmission electron microscopy (EM) and discovered that their conformational heterogeneity is dramatically reduced in the presence of a low concentration of dimethyl sulfoxide, allowing for an efficient flattening onto the carbon support of an EM grid. We further demonstrated that streptavidin and a biotinylated target protein (cocaine esterase, CocE) can be captured at predesignated sites on these flattened origami while maintaining their functional integrity. Our demonstration that protein assemblies can be constructed with high spatial precision (within ∼2 nm of their predicted position on the platforms) by using strategically flattened single-layer origami paves the way for exploiting well-defined guest molecule assemblies for biochemistry and nanotechnology applications.
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Search skip specific nav links Home arrow The National Historic Preservation Program arrow ACHP Policy Statements ACHP Policy Statements ACHP Policy Statement on Controversial Commemorative Works ACHP Policy Statement on Historic Preservation and Community Revitalizations Policy Statement on the ACHP's Interaction
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National Guard > Resources > Image Gallery
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Guard News - The National Guard
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Featured Videos - The National Guard
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ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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News Images - The National Guard
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ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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State Websites - The National Guard
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Helpful Links - The National Guard
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Sandia National Laboratories: Directed-energy tech receives funding to
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Skip to main content (Press Enter). DOD Open Government Logo DOD Open Government U.S. Department of Defense Search DOD Open Government: Home Open Government @ DoD Transparency Congressional Inquiries Cooperation Regulatory Program Initiatives FRD Declassification DARPA Open Catalog Contact Us Freedom of
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Skip to content South Carolina Department of Health and Environmental Control Search Button RSS Services Programs/Divisions Report State Agency Fraud Health Health All Health Topics Child and Teen Health Data, Maps - SC Public Health Diseases and Conditions Flu Tuberculosis STD/HIV and Viral Hepatitis Zika
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Skip to content South Carolina Department of Health and Environmental Control Search Button RSS Services Programs/Divisions Report State Agency Fraud Health Health All Health Topics Child and Teen Health Data, Maps - SC Public Health Diseases and Conditions Flu Tuberculosis STD/HIV and Viral Hepatitis Zika
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DHEC: General Agency Information
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Environmental Management. Responsibilities The Depleted UF6 Management Program Information Network web site is management, or national defense. For More Information: Contact the Depleted UF6 Webmaster: Robert Sullivan DUF6 Management and Uses DUF6 Conversion EIS Documents News FAQs Internet Resources Glossary Home Â
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Senior Enlisted Advisor to the CNGB - The National Guard
, Army Good Conduct Medal, Army Service Ribbon, National Defense Service Ribbon, Armed Forces Reserve ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training
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Institutes and provides genotyping, sequencing and statistical genetic services to investigators approved for access through competitive peer review. An application is required for projects supported by the NIH CIDR Two pathways exist to access the CIDR facility: NIH CIDR Program The CIDR contract is funded by 10 NIH
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Membership in CBE's Industry Consortium
Membership Benefits of Membership Membership FAQs Become a Member Board Meeting Logistics CBE's Overview CBE's research program is supported and guided by its Industry Advisory Board (IAB). Twice a year projects, and identify new research topics. Our Industry Advisory Board mirrors the diversity of the
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Innovation and Entrepreneurship | NREL
disadvantaged businesses. Programs A photo of a woman and a man creating a planning diagram. Energy I-Corps (DOE) national laboratory-developed technologies into the commercial marketplace. Read more A photo of two men working on a machine. Small Business Vouchers Pilot Provides selected clean energy small
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Statistics Quality Control Statistics CIDR is dedicated to producing the highest quality data for our investigators. These cumulative quality control statistics are based on data from 419 released CIDR Program
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Integration program, developing inverse modeling algorithms to calibrate building energy models, and is part related equipment. This work included developing an engineering grade operator training simulator for an
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OHD/SRC - Collaborative Research Projects
Collaborative Research Program Current Announcement Past Announcements Collaborative Research Projects General services. Collaborative Research Projects Fiscal Year 2004 Fiscal Year 2007 Fiscal Year 2008 Fiscal Year
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Publications - IC 52 | Alaska Division of Geological & Geophysical Surveys
Mapping Advisory Board STATEMAP Publications Geophysics Program Information Geophysical Survey ; Aerial Photography; Aeromagnetic; Aeromagnetic Data; Aeromagnetic Survey; Airborne Geophysical Survey Resistivity Data; Apparent Resistivity Map; Apparent Resistivity Survey; Arctic Deposit; Arsenic; Arsenopyrite
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Publications - IC 51 | Alaska Division of Geological & Geophysical Surveys
Mapping Advisory Board STATEMAP Publications Geophysics Program Information Geophysical Survey Photography; Aeromagnetic; Aeromagnetic Data; Aeromagnetic Survey; Airborne Geophysical Survey; Alaska Data; Apparent Resistivity Map; Apparent Resistivity Survey; Arctic Deposit; Arsenic; Arsenopyrite
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Publications - SR 61 | Alaska Division of Geological & Geophysical Surveys
Mapping Advisory Board STATEMAP Publications Geophysics Program Information Geophysical Survey K) Keywords Admiralty Island; Aeromagnetic Data; Aeromagnetic Survey; Airborne Geophysical Survey Dome; Conductivity Survey; Construction Materials; Copper; Core Drilling; Council; Crushed Gravel
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Energy - Sandia National Laboratories
; Components Compatibility Hydrogen Behavior Quantitative Risk Assessment Technical Reference for Hydrogen Combustion jbei Facilities Algae Testbed Battery Abuse Testing Laboratory Center for Infrastructure Research and Innovation Combustion Research Facility Joint BioEnergy Institute Close Energy Research Programs
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; Components Compatibility Hydrogen Behavior Quantitative Risk Assessment Technical Reference for Hydrogen Combustion jbei Facilities Algae Testbed Battery Abuse Testing Laboratory Center for Infrastructure Research and Innovation Combustion Research Facility Joint BioEnergy Institute Close Energy Research Programs
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Stationary Power - Sandia Energy
; Components Compatibility Hydrogen Behavior Quantitative Risk Assessment Technical Reference for Hydrogen Combustion jbei Facilities Algae Testbed Battery Abuse Testing Laboratory Center for Infrastructure Research and Innovation Combustion Research Facility Joint BioEnergy Institute Close Energy Research Programs
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Transportation Energy - Sandia Energy
; Components Compatibility Hydrogen Behavior Quantitative Risk Assessment Technical Reference for Hydrogen Combustion jbei Facilities Algae Testbed Battery Abuse Testing Laboratory Center for Infrastructure Research and Innovation Combustion Research Facility Joint BioEnergy Institute Close Energy Research Programs
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Grid Modernization - Sandia Energy
; Components Compatibility Hydrogen Behavior Quantitative Risk Assessment Technical Reference for Hydrogen Combustion jbei Facilities Algae Testbed Battery Abuse Testing Laboratory Center for Infrastructure Research and Innovation Combustion Research Facility Joint BioEnergy Institute Close Energy Research Programs
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Home | Sonoma County Water Agency
Precipitation Information (AQPI) Fluoridation Atmospheric Rivers Urban Water Management Plan Flood Protection Advanced Quantitative Precipitation Information (AQPI) Fluoridation Atmospheric Rivers Urban Water Management Plan Flood Protection Flood Forecast/Emergency Info Stream Maintenance Program Flood Protection
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Sandia National Laboratories: National Security Missions: International
Transportation Energy Energy Research Global Security WMD Counterterrorism & Response Global Threat Reduction Homeland Defense & Force Protection Homeland Security Cyber & Infrastructure Security Global Business Procurement Technical Assistance Program (PTAP) Current Suppliers iSupplier Account Accounts
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ACHP | Working Together to Build a More Inclusive Preservation Program
; landscape architecture history and architectural history; history; GIS; along with landscape design. Do you " project. The site is a National Historic Landmark with 147 years of military history. The project
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Sandia National Laboratories: News: Publications: Environmental Reports
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Sandia National Laboratories: Sandia National Laboratories: News: Events
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Sandia National Laboratories: About Sandia: Environmental Responsibility
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Sandia National Laboratories: About Sandia: Community Involvement
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Sandia National Laboratories: News: Publications: HPC Reports
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Sandia National Laboratories: News: Search Sandia Publications
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Sandia National Laboratories: Working with Sandia: Small Business
Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios
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Sandia National Laboratories: Microsystems Science & Technology Center
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Sandia National Laboratories: News: Publications: Strategic Plan
Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios
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Sandia National Laboratories: News: Media Resources: Media Contacts
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Sandia National Laboratories: Employee & Retiree Resources: Technical
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Sandia National Laboratories: Z Pulsed Power Facility
Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios
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Sandia National Laboratories: National Security Missions: Defense Systems
; Technology Defense Systems & Assessments About Defense Systems & Assessments Program Areas Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios
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Sandia National Laboratories: Advanced Simulation and Computing
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Sandia National Laboratories: News: Publications: Annual Report
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Sandia National Laboratories: Employee & Retiree Resources: Remote Access
Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios
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National Guard > Leadership > Joint Staff > Special Staff > Chaplain
ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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About the Air National Guard - The National Guard
ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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Overseas Operations News - The National Guard
ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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Your National Guard - The National Guard
ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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Chief, National Guard Bureau - Leadership - The National Guard
ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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The National Guard - Official Website of the National Guard
ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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National Guard Bureau Posture Statement - The National Guard
ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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Personal Staff - Joint Staff - The National Guard
ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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Special Staff - Joint Staff - Leadership - The National Guard
ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications
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Michigan field artillery's 'Blackjacks' training in Latvia > National Guard
Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications Civic Leader's Guide ARNG Vision 2020 Posture Statement
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Department of Pesticide Regulation Databases
; Safety Report an Illness | Food Safety | Risk Assessment & Mitigation | Human Health | Physicians Endangered Species Enforcement Food Safety Forms Human Health Laws Licensing Mill Assessment Permitting Pest Statewide search: Search Search Search this site: Search Search DPR California Home Programs Health &
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California Department of Pesticide Regulation Home Page
; Safety Report an Illness | Food Safety | Risk Assessment & Mitigation | Human Health | Physicians Endangered Species Enforcement Food Safety Forms Human Health Laws Licensing Mill Assessment Permitting Pest Statewide search: Search Search Search this site: Search Search DPR California Home Programs Health &
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Propane Education, Research, and Training The Propane Education and Research Act of 1996 established the Propane Education and Research Council (PERC) to develop programs education and training efforts to promote the use of propane as an alternative fuel. The Propane Education and Research
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Clean School Bus Program Any school district or charter school may receive a grant through the Texas Commission on Environmental Quality (TCEQ) to pay for the incremental costs to replace school equipment, and other emissions reduction technologies in qualified school buses. Furthermore, funds may also
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Batteries and Energy Storage | Argonne National Laboratory
-energy density lithium-ion batteries, while using our fundamental science capabilities to develop storage ), headquartered at Argonne National Laboratory, seeks to develop new technologies that move beyond lithium-ion Transportation SPOTLIGHT Batteries and Energy Storage Argonne's all- encompassing battery research program spans
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technological and implementation barriers faced by the residential construction industry. Prior to working at provides technical research management for DOE's Building America Program. In this role, she works to
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, engineering and computing. Working with Fermilab scientists or engineers, interns have an opportunity to four quarters at Fermilab, alternating periods of full-time study at their schools with full-time
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Structural basis for gating and activation of RyR1
des Georges, Amédée; Clarke, Oliver B.; Zalk, Ran; Yuan, Qi; Condon, Kendall J.; Grassucci, Robert A.; Hendrickson, Wayne A.; Marks, Andrew R.; Frank, Joachim
2016-01-01
Summary The type-1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel required for skeletal muscle contraction. Here we present cryo-EM reconstructions of RyR1 in multiple functional states revealing the structural basis of channel gating and ligand-dependent activation. Binding sites for the channel activators Ca2+, ATP and caffeine were identified at interdomain interfaces of the C-terminal domain. Either ATP or Ca2+ alone induce conformational changes in the cytoplasmic assembly (‘priming’), without pore dilation. In contrast, in the presence of all three activating ligands, high-resolution reconstructions of open and closed states of RyR1 were obtained from the same sample, enabling analyses of conformational changes associated with gating. Gating involves global conformational changes in the cytosolic assembly accompanied by local changes in the transmembrane domain, which include bending of the S6 transmembrane segment and consequent pore dilation, displacement and deformation of the S4-S5 linker, and conformational changes in the pseudo-voltage-sensor domain. PMID:27662087
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Smoot Astrophysics Research Program
the same basic force and have frozen out to different forces in the cooler present Universe. We see Implications of the COBE DMR Map of the Early Universe What COBE DMR saw: The COBE DMR (Cosmic Background Explorer Differential Microwave Radiometer) mapped the microwave (wavelengths of 9, 5,6, and 3.3
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, graphs, or information about datasets). A RESTful web service (external link) - a URL that computer to get the same information in a more computer-program-friendly format like JSON (external link .jsonlKVP, where column names are on every row): Each column has a column name and one type of information
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Biotechnology Process Engineering Center at MIT Home
is speaking at the 2004 Congressional Biomedical Research Caucus Briefings on July 14th. Her briefing | Education & Outreach | Research | Industrial Programs | Student Leadership Council Facilities | Umbrella
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United States Nuclear Data Program (USNDP)
Report FY 2016 Annual Report FY 2015 Annual Report FY 2014 Annual Report FY 2013 Annual Report FY 2012 Annual Report FY 2011 Annual Report FY 2010 Annual Report FY 2009 Annual Report FY 2008 Annual Report FY 2007 Annual Report FY 2006 Annual Report FY 2005 Annual Report FY 2004 Final Report FY 2003 Final
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Virginia Water Resources Research Center - at Virginia Tech since 1965
Virginia Water Resources Research Center at Virginia Tech since 1965 Search for: Search Skip to collaborative research, extension, and education programs to develop solutions to water resource challenges. We Monitoring Council Conference: March 21, 2018 The Virginia Water Resources Research Center at Virginia Tech
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Geothermal Technologies News | Geothermal Technologies | NREL
for this avid biker. The reason though is unusual. Passionate about geothermal energy research, he Geothermal Energy Program In her new role, Young will work closely with NREL management to establish the lab's geothermal energy portfolio, including research and development geared toward advancing the use of
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Energy Systems Integration Facility News | Energy Systems Integration
, 2018 News Release: NREL Taps Young to Oversee Geothermal Energy Program In her new role, Young will work closely with NREL management to establish the lab's geothermal energy portfolio, including research and development geared toward advancing the use of geothermal energy as a renewable power source
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Ocean Drilling Program: Drilling Services
Drilling operations team Material services team Development engineering team ODP/TAMU Science Operator Home Services department consists of three team-oriented project groups, which also work to improve the existing team. A member of this team sails with each cruise to provide expertise for the shipboard scientific
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Publications - SR 60 | Alaska Division of Geological & Geophysical Surveys
Mapping Advisory Board STATEMAP Publications Geophysics Program Information Geophysical Survey ; Aeromagnetic Survey; Airborne Geophysical Survey; Alaska Highway Corridor; Alaska Peninsula; Alaska, State of ; Bismuth; Chalcopyrite; Chandalar Mining District; Cleary Summit; Coal; Conductivity Survey; Construction
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Publications - IC 46 | Alaska Division of Geological & Geophysical Surveys
Mapping Advisory Board STATEMAP Publications Geophysics Program Information Geophysical Survey ; Aeromagnetic; Aeromagnetic Survey; Airborne Geophysical Survey; Antimony; Arsenic; Arsenopyrite; Base Metals ; Electromagnetic Data; Electromagnetic Survey; Exploration; Fairbanks Mining District; Fort Knox Mine; Fortymile
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Energy Fact Sheets - Sandia Energy
; Components Compatibility Hydrogen Behavior Quantitative Risk Assessment Technical Reference for Hydrogen Combustion jbei Facilities Algae Testbed Battery Abuse Testing Laboratory Center for Infrastructure Research and Innovation Combustion Research Facility Joint BioEnergy Institute Close Energy Research Programs
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Los Alamos National Laboratory Search Site submit About Mission Business Newsroom Publications Los Innovation in New Mexico Los Alamos Collaboration for Explosives Detection (LACED) SensorNexus Exascale Computing Project (ECP) User Facilities Center for Integrated Nanotechnologies (CINT) Los Alamos Neutron
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Los Alamos National Laboratory Search Site submit About Mission Business Newsroom Publications Los Innovation in New Mexico Los Alamos Collaboration for Explosives Detection (LACED) SensorNexus Exascale Computing Project (ECP) User Facilities Center for Integrated Nanotechnologies (CINT) Los Alamos Neutron
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Los Alamos National Laboratory Search Site submit About Mission Business Newsroom Publications Los Innovation in New Mexico Los Alamos Collaboration for Explosives Detection (LACED) SensorNexus Exascale Computing Project (ECP) User Facilities Center for Integrated Nanotechnologies (CINT) Los Alamos Neutron
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Working with Section 106 Federal, State, & Tribal Programs Training & Education Publications Search Youth & Historic Preservation Recovery Act skip specific nav links Home arrow Training and Education Training and Education Section 106 Classroom Training Instructor-led Webinars on Section 106
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links at each of these sites. General Links AgriNet-Texas A&M Agricultural Program - Agricultural University Extension National Agricultural Statistics Service (NASS) 2013 NASS Census of Aquaculture National Agricultural Library National Fisheries Institute National Sea Grant Netvet North Central Regional Aquaculture
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Sandia National Laboratories: What Sandia Looks For In Our Suppliers
Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios
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Sandia National Laboratories: Working with Sandia: What Does Sandia Buy?
Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios
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Sandia National Laboratories: Sandia inks pact with Fire and Rescue
; Technology Defense Systems & Assessments About Defense Systems & Assessments Program Areas Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios
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Scientific programming and high performance computing Research Interests Wind and solar resource assessment , Department of Geography and Environmental Sciences, Denver, CO Research Assistant, National Center for Atmospheric Research (NCAR), Boulder, CO Graduate Instructor and Research Assistant, University of Colorado
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United States Census Bureau Topics Population Latest Information Age and Sex Ancestry Children Mobility Population Estimates Population Projections Race Veterans Economy Latest Information Portal Other Economic Programs Business Latest Information Business Characteristics Classification Codes
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United States Census Bureau Topics Population Latest Information Age and Sex Ancestry Children Mobility Population Estimates Population Projections Race Veterans Economy Latest Information Portal Other Economic Programs Business Latest Information Business Characteristics Classification Codes
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United States Census Bureau Topics Population Latest Information Age and Sex Ancestry Children Mobility Population Estimates Population Projections Race Veterans Economy Latest Information Portal Other Economic Programs Business Latest Information Business Characteristics Classification Codes
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United States Census Bureau Topics Population Latest Information Age and Sex Ancestry Children Mobility Population Estimates Population Projections Race Veterans Economy Latest Information Portal Other Economic Programs Business Latest Information Business Characteristics Classification Codes
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United States Census Bureau Topics Population Latest Information Age and Sex Ancestry Children Mobility Population Estimates Population Projections Race Veterans Economy Latest Information Portal Other Economic Programs Business Latest Information Business Characteristics Classification Codes
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United States Census Bureau Topics Population Latest Information Age and Sex Ancestry Children Mobility Population Estimates Population Projections Race Veterans Economy Latest Information Portal Other Economic Programs Business Latest Information Business Characteristics Classification Codes
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NREL Employee Appointed to Presidential Panel
Employee Appointed to Presidential Panel For more information contact: e:mail: Public Affairs Development Panel. The panel will review current and projected U.S. energy research and development programs
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On-Farm Biofuel Production Grants The Governor's Office of Agricultural Policy provides grants through the County Agricultural Investment Program for on-farm energy efficiency and renewable energy Agricultural Development Fund
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Publications - MP 158 | Alaska Division of Geological & Geophysical Surveys
Portal Climate and Cryosphere Hazards Coastal Hazards Program Guide to Geologic Hazards in Alaska Deposits; Bluff; Coastal; Coastal Erosion; Depositional Environment; Dunes; Engineering Geology; Flood
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Fermilab | Science at Fermilab | Theory
future direction of experimental programs. Experimental results, in turn, can confirm or rule out GPS satellites, rely on the advances made in experimental and theoretical physics. Without a firm
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Community Solar Scenario Tool | Integrated Energy Solutions | NREL
Community Solar Scenario Tool Community Solar Scenario Tool The Community Solar Scenario Tool (CSST ) provides a "first cut" analysis of different community or shared solar program options. NREL sponsoring utility. Community Solar Scenario Tool -Beta Version Available as a Microsoft Excel file, which
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The Next Linear Collider Program
Navbar Other Address Books: Laboratory Phone/Email Web Directory SLAC SLAC Phonebook Entire SLAC Web FNAL Telephone Directory Fermilab Search LLNL Phone Book LLNL Web Servers LBNL Directory Services Web Search: A-Z Index KEK E-mail Database Research Projects NLC Website Search: Entire SLAC Web | Help
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Fleet Management | Climate Neutral Research Campuses | NREL
Fleet Management Fleet Management Research campuses often own and operate vehicles to carry out Sample Project Related Links Fleet Management Options The goal of fleet management within climate action alternative fuel use. The U.S. Department of Energy (DOE) Federal Energy Management Program (FEMP) outlines
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AFV special license plate, which are available from the Arizona Department of Transportation (ADOT license plate. ADOT has reached its maximum limit of 10,000 vehicles and the issuance of Energy Efficient Alternative Fuel Vehicle (AFV) and Energy Efficient Plate Programs Dedicated AFVs qualify for an
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Safety Information, Transportation & Public Facilities, State of Alaska
Department of Transportation & Public Facilities/ Safety Information Search DOT&PF State of Alaska DOT&PF> Safety Information DOT&PF Safety Information link to 511 511.alaska.gov - Traveler Information link to AHSO Alaska Highway Safety Office link to HSIP Highway Safety Improvement Program link to
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. Photo: Elliott McCrory On March 3, 71 local high school students graduated from the winter session of Figures STEM program for local students February 20, 2018 | Sarah Lawhun After watching short videos on Students and teachers Media News Navbar Toggle Newsroom News and features Press releases Fermilab in the
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Judge Advocate (NGB-JA) - Personal Staff - Joint Staff - The National Guard
training. Assists in identifying NG JAs to meet service operational requirements. And Coordinates and ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training
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Principal Assistant Responsible for Contracting (PARC) - J8 - The National
Officer of the ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News
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Long before smartphones, National Guard responded to nationwide muster in
Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & ; Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications Civic Leader's Guide ARNG
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ACHP | "The Section 106 Essentials" Course
Working with Section 106 Federal, State, & Tribal Programs Training & Education Publications Search skip specific nav links Home arrow Training and Education arrow The Section 106 Training Courses SECTION 106 TRAINING COURSES Why choose the ACHP for Section 106 training? Up-to-the-minute regulatory
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Massachusetts Air National Guard dad deploys with his son for final time >
Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications Civic Leader's Guide ARNG Vision 2020 Posture
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National Guard Bureau Office of Legislative Liaison - The National Guard
ARNG Command Sergeant Major of the ARNG State Mission Sustainability Training ARNG Distributed Learning Program Training & Technology Battle Lab (T3BL) Civil Support Simulation Exercises Regional Training Site Maintenance Battle Focused Training Strategy Battle Staff Training Resources News Publications