Sample records for endogenous electric fields

  1. Endogenous Cortical Oscillations Constrain Neuromodulation by Weak Electric Fields

    PubMed Central

    Schmidt, Stephen L.; Iyengar, Apoorva K.; Foulser, A. Alban; Boyle, Michael R.; Fröhlich, Flavio

    2014-01-01

    Background Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation modality that may modulate cognition by enhancing endogenous neocortical oscillations with the application of sine-wave electric fields. Yet, the role of endogenous network activity in enabling and shaping the effects of tACS has remained unclear. Objective We combined optogenetic stimulation and multichannel slice electrophysiology to elucidate how the effect of weak sine-wave electric field depends on the ongoing cortical oscillatory activity. We hypothesized that the structure of the response to stimulation depended on matching the stimulation frequency to the endogenous cortical oscillation. Methods We studied the effect of weak sine-wave electric fields on oscillatory activity in mouse neocortical slices. Optogenetic control of the network activity enabled the generation of in vivo like cortical oscillations for studying the temporal relationship between network activity and sine-wave electric field stimulation. Results Weak electric fields enhanced endogenous oscillations but failed to induce a frequency shift of the ongoing oscillation for stimulation frequencies that were not matched to the endogenous oscillation. This constraint on the effect of electric field stimulation imposed by endogenous network dynamics was limited to the case of weak electric fields targeting in vivo-like network dynamics. Together, these results suggest that the key mechanism of tACS may be enhancing but not overriding of intrinsic network dynamics. Conclusion Our results contribute to understanding the inconsistent tACS results from human studies and propose that stimulation precisely adjusted in frequency to the endogenous oscillations is key to rational design of non-invasive brain stimulation paradigms. PMID:25129402

  2. Endogenous field feedback promotes the detectability for exogenous electric signal in the hybrid coupled population.

    PubMed

    Wei, Xile; Zhang, Danhong; Lu, Meili; Wang, Jiang; Yu, Haitao; Che, Yanqiu

    2015-01-01

    This paper presents the endogenous electric field in chemical or electrical synaptic coupled networks, aiming to study the role of endogenous field feedback in the signal propagation in neural systems. It shows that the feedback of endogenous fields to network activities can reduce the required energy of the noise and enhance the transmission of input signals in hybrid coupled populations. As a common and important nonsynaptic interactive method among neurons, particularly, the endogenous filed feedback can not only promote the detectability of exogenous weak signal in hybrid coupled neural population but also enhance the robustness of the detectability against noise. Furthermore, with the increasing of field coupling strengths, the endogenous field feedback is conductive to the stochastic resonance by facilitating the transition of cluster activities from the no spiking to spiking regions. Distinct from synaptic coupling, the endogenous field feedback can play a role as internal driving force to boost the population activities, which is similar to the noise. Thus, it can help to transmit exogenous weak signals within the network in the absence of noise drive via the stochastic-like resonance.

  3. The influence of electric field and confinement on cell motility.

    PubMed

    Huang, Yu-Ja; Samorajski, Justin; Kreimer, Rachel; Searson, Peter C

    2013-01-01

    The ability of cells to sense and respond to endogenous electric fields is important in processes such as wound healing, development, and nerve regeneration. In cell culture, many epithelial and endothelial cell types respond to an electric field of magnitude similar to endogenous electric fields by moving preferentially either parallel or antiparallel to the field vector, a process known as galvanotaxis. Here we report on the influence of dc electric field and confinement on the motility of fibroblast cells using a chip-based platform. From analysis of cell paths we show that the influence of electric field on motility is much more complex than simply imposing a directional bias towards the cathode or anode. The cell velocity, directedness, as well as the parallel and perpendicular components of the segments along the cell path are dependent on the magnitude of the electric field. Forces in the directions perpendicular and parallel to the electric field are in competition with one another in a voltage-dependent manner, which ultimately govern the trajectories of the cells in the presence of an electric field. To further investigate the effects of cell reorientation in the presence of a field, cells are confined within microchannels to physically prohibit the alignment seen in 2D environment. Interestingly, we found that confinement results in an increase in cell velocity both in the absence and presence of an electric field compared to migration in 2D.

  4. THE ROLE OF ELECTRICAL SIGNALS IN MURINE CORNEAL WOUND RE-EPITHELIALISATION

    PubMed Central

    Kucerova, R.; Walczysko, P.; Reid, B.; Ou, J.; Leiper, L. J.; Rajnicek, A. M.; McCaig, C. D.; Zhao, M.; Collinson, J. M.

    2011-01-01

    Ion flow from intact tissue into epithelial wound sites results in lateral electric currents that may represent a major driver of wound healing cell migration. Use of applied electric fields to promote wound healing is the basis of Medicare-approved electric stimulation therapy. This study investigated the roles for electric fields in wound re-epithelialisation, using the Pax6+/− mouse model of the human ocular surface abnormality aniridic keratopathy (in which wound healing and corneal epithelial cell migration are disrupted). Both wild-type and Pax6+/− corneal epithelial cells showed increased migration speeds in response to applied electric fields in vitro. However, only Pax6+/+ cells demonstrated directional galvanotaxis towards the cathode, with activation of pSrc signalling, polarised to the leading edges of cells. In vivo, the epithelial wound site normally represents a cathode, but 43% of Pax6+/− corneas exhibited reversed endogenous wound-induced currents (the wound was an anode). These corneas healed at the same rate as wild-type. Surprisingly, epithelial migration did not correlate with direction or magnitude of endogenous currents for wild-type or mutant corneas. Furthermore, during healing in vivo, no polarisation of pSrc was observed. We found little evidence that Src-dependent mechanisms of cell migration, observed in response to applied EFs in vitro, normally exist in vivo. It is concluded that endogenous electric fields do not drive long-term directionality of sustained healing migration in this mouse corneal epithelial model. Ion flow from wounds may nevertheless represent an important component of wound signalling initiation. PMID:20945376

  5. Comparison of cardiac and 60 Hz magnetically induced electric fields measured in anesthetized rats

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miller, D.L.; Creim, J.A.

    1997-06-01

    Extremely low frequency magnetic fields interact with an animal by inducing internal electric fields, which are in addition to the normal endogenous fields present in living animals. Male rats weighing about 560 g each were anesthetized with ketamine and xylazine. Small incisions were made in the ventral body wall at the chest and upper abdomen to position a miniature probe for measuring internal electric fields. The calibration constant for the probe size was 5.7 mm, with a flat response from at least 12 Hz to 20 kHz. A cardiac signal, similar to the normal electrocardiogram with a heart rate ofmore » about 250 bpm, was readily obtained at the chest. Upon analysis of its spectrum, the cardiac field detected by the probe had a broad maximum at 32--95 Hz. When the rates were exposed to a 1 mT, 60 Hz magnetic field, a spike appeared in the spectrum at 60 Hz. The peak-to-peak magnitudes of electric fields associated with normal heart function were comparable to fields induced by a 1 mT magnetic field at 60 Hz for those positions measured on the body surface. Within the body, or in different directions relative to the applied field, the induced fields were reduced. The cardiac field increased near the heart, becoming much larger than the induced field. Thus, the cardiac electric field, together with the other endogenous fields, combine with induced electric fields and help to provide reference levels for the induced-field dosimetry of ELF magnetic field exposures of living animals.« less

  6. Synaptic Effects of Electric Fields

    NASA Astrophysics Data System (ADS)

    Rahman, Asif

    Learning and sensory processing in the brain relies on the effective transmission of information across synapses. The strength and efficacy of synaptic transmission is modifiable through training and can be modulated with noninvasive electrical brain stimulation. Transcranial electrical stimulation (TES), specifically, induces weak intensity and spatially diffuse electric fields in the brain. Despite being weak, electric fields modulate spiking probability and the efficacy of synaptic transmission. These effects critically depend on the direction of the electric field relative to the orientation of the neuron and on the level of endogenous synaptic activity. TES has been used to modulate a wide range of neuropsychiatric indications, for various rehabilitation applications, and cognitive performance in diverse tasks. How can a weak and diffuse electric field, which simultaneously polarizes neurons across the brain, have precise changes in brain function? Designing therapies to maximize desired outcomes and minimize undesired effects presents a challenging problem. A series of experiments and computational models are used to define the anatomical and functional factors leading to specificity of TES. Anatomical specificity derives from guiding current to targeted brain structures and taking advantage of the direction-sensitivity of neurons with respect to the electric field. Functional specificity originates from preferential modulation of neuronal networks that are already active. Diffuse electric fields may recruit connected brain networks involved in a training task and promote plasticity along active synaptic pathways. In vitro, electric fields boost endogenous synaptic plasticity and raise the ceiling for synaptic learning with repeated stimulation sessions. Synapses undergoing strong plasticity are preferentially modulated over weak synapses. Therefore, active circuits that are involved in a task could be more susceptible to stimulation than inactive circuits. Moreover, stimulation polarity has asymmetric effects on synaptic strength making it easier to enhance ongoing plasticity. These results suggest that the susceptibility of brain networks to an electric field depends on the state of synaptic activity. Combining a training task, which activates specific circuits, with TES may lead to functionally-specific effects. Given the simplicity of TES and the complexity of brain function, understanding the mechanisms leading to specificity is fundamental to the rational advancement of TES.

  7. Lymphocyte Electrotaxis in vitro and in vivo

    PubMed Central

    Lin, Francis; Baldessari, Fabio; Gyenge, Christina Crenguta; Sato, Tohru; Chambers, Robert D.; Santiago, Juan G.; Butcher, Eugene C.

    2008-01-01

    Electric fields are generated in vivo in a variety of physiologic and pathologic settings, including penetrating injury to epithelial barriers. An applied electric field with strength within the physiologic range can induce directional cell migration (i.e. electrotaxis) of epithelial cells, endothelial cells, fibroblasts, and neutrophils suggesting a potential role in cell positioning during wound healing. In the present study, we investigated the ability of lymphocytes to respond to applied direct current (DC) electric fields. Using a modified transwell assay and a simple microfluidic device, we show that human peripheral blood lymphocytes migrate toward the cathode in physiologically relevant DC electric fields. Additionally, electrical stimulation activates intracellular kinase signaling pathways shared with chemotactic stimuli. Finally, video microscopic tracing of GFP-tagged immunocytes in the skin of mouse ears reveals that motile cutaneous T cells actively migrate toward the cathode of an applied DC electric field. Lymphocyte positioning within tissues can thus be manipulated by externally applied electric fields, and may be influenced by endogenous electrical potential gradients as well. PMID:18684937

  8. Lymphocyte electrotaxis in vitro and in vivo.

    PubMed

    Lin, Francis; Baldessari, Fabio; Gyenge, Christina Crenguta; Sato, Tohru; Chambers, Robert D; Santiago, Juan G; Butcher, Eugene C

    2008-08-15

    Electric fields are generated in vivo in a variety of physiologic and pathologic settings, including penetrating injury to epithelial barriers. An applied electric field with strength within the physiologic range can induce directional cell migration (i.e., electrotaxis) of epithelial cells, endothelial cells, fibroblasts, and neutrophils suggesting a potential role in cell positioning during wound healing. In the present study, we investigated the ability of lymphocytes to respond to applied direct current (DC) electric fields. Using a modified Transwell assay and a simple microfluidic device, we show that human PBLs migrate toward the cathode in physiologically relevant DC electric fields. Additionally, electrical stimulation activates intracellular kinase signaling pathways shared with chemotactic stimuli. Finally, video microscopic tracing of GFP-tagged immunocytes in the skin of mouse ears reveals that motile cutaneous T cells actively migrate toward the cathode of an applied DC electric field. Lymphocyte positioning within tissues can thus be manipulated by externally applied electric fields, and may be influenced by endogenous electrical potential gradients as well.

  9. Cellular responses to endogenous electrochemical gradients in morphological development

    NASA Technical Reports Server (NTRS)

    Desrosiers, M. F.

    1996-01-01

    Endogenous electric fields give vectorial direction to morphological development in Zea mays (sweet corn) in response to gravity. Endogenous electrical fields are important because of their ability to influence: (1) intercellular organization and development through their effects on the membrane potential, (2) direct effects such as electrophoresis of membrane components, and (3) both intracellular and extracellular transport of charged compounds. Their primary influence is in providing a vectorial dimension to the progression of one physiological state to another. Gravity perception and transduction in the mesocotyl of vascular plants is a complex interplay of electrical and chemical gradients which ultimately provide the driving force for the resulting growth curvature called gravitropism. Among the earliest events in gravitropism are changes in impedance, voltage, and conductance between the vascular stele and the growth tissues, the cortex, in the mesocotyl of corn shoots. In response to gravistimulation: (1) a potential develops which is vectorial and of sufficient magnitude to be a driving force for transport between the vascular stele and cortex, (2) the ionic conductance changes within seconds showing altered transport between the tissues, and (3) the impedance shows a transient biphasic response which indicates that the mobility of charges is altered following gravistimulation and is possibly the triggering event for the cascade of actions which leads to growth curvature.

  10. Adult subependymal neural precursors, but not differentiated cells, undergo rapid cathodal migration in the presence of direct current electric fields.

    PubMed

    Babona-Pilipos, Robart; Droujinine, Ilia A; Popovic, Milos R; Morshead, Cindi M

    2011-01-01

    The existence of neural stem and progenitor cells (together termed neural precursor cells) in the adult mammalian brain has sparked great interest in utilizing these cells for regenerative medicine strategies. Endogenous neural precursors within the adult forebrain subependyma can be activated following injury, resulting in their proliferation and migration toward lesion sites where they differentiate into neural cells. The administration of growth factors and immunomodulatory agents following injury augments this activation and has been shown to result in behavioural functional recovery following stroke. With the goal of enhancing neural precursor migration to facilitate the repair process we report that externally applied direct current electric fields induce rapid and directed cathodal migration of pure populations of undifferentiated adult subependyma-derived neural precursors. Using time-lapse imaging microscopy in vitro we performed an extensive single-cell kinematic analysis demonstrating that this galvanotactic phenomenon is a feature of undifferentiated precursors, and not differentiated phenotypes. Moreover, we have shown that the migratory response of the neural precursors is a direct effect of the electric field and not due to chemotactic gradients. We also identified that epidermal growth factor receptor (EGFR) signaling plays a role in the galvanotactic response as blocking EGFR significantly attenuates the migratory behaviour. These findings suggest direct current electric fields may be implemented in endogenous repair paradigms to promote migration and tissue repair following neurotrauma.

  11. Electricity and colloidal stability: how charge distribution in the tissue can affects wound healing.

    PubMed

    Farber, Paulo Luiz; Hochman, Bernardo; Furtado, Fabianne; Ferreira, Lydia Masako

    2014-02-01

    The role of endogenous electric fields in wound healing is still not fully understood. Electric fields are of fundamental importance in various biological processes, ranging from embryonic development to disease progression, as described by many investigators in the last century. This hypothesis brings together some relevant literature on the importance of electric fields in physiology and pathology, the theory of biologically closed electric circuits, skin battery (a phenomenon that occurs after skin injury and seems to be involved in tissue repair), the relationship between electric charge and interstitial exclusion, and how skin tissues can be regarded as colloidal systems. The importance of electric charges, as established in the early works on the subject and the relevance of zeta potential and colloid stability are also analyzed, and together bring a new light for the physics involved in the wound repair of all the body tissues. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. ELECTRICAL SIGNALING IN CONTROL OF OCULAR CELL BEHAVIORS

    PubMed Central

    Zhao, Min; Chalmers, Laura; Cao, Lin; Viera, Ana C.; Mannis, Mark; Reid, Brian

    2011-01-01

    Epithelia of the cornea, lens and retina contain a vast array of ion channels and pumps. Together they produce a polarized flow of ions in and out of cells, as well as across the epithelia. These naturally occurring ion fluxes are essential to the hydration and metabolism of the ocular tissues, especially for the avascular cornea and lens. The directional transport of ions generates electric fields and currents in those tissues. Applied electric fields affect migration, division and proliferation of ocular cells which are important in homeostasis and healing of the ocular tissues. Abnormalities in any of those aspects may underlie many ocular diseases, for example chronic corneal ulcers, posterior capsule opacity after cataract surgery, and retinopathies. Electric field-inducing cellular responses, termed electrical signaling here, therefore may be an unexpected yet powerful mechanism in regulating ocular cell behavior. Both endogenous electric fields and applied electric fields could be exploited to regulate ocular cells. We aim to briefly describe the physiology of the naturally occurring electrical activities in the corneal, lens, and retinal epithelia, to provide experimental evidence of the effects of electric fields on ocular cell behaviors, and to suggest possible clinical implications. PMID:22020127

  13. In vitro effects of direct current electric fields on adipose-derived stromal cells.

    PubMed

    Hammerick, Kyle E; Longaker, Michael T; Prinz, Fritz B

    2010-06-18

    Endogenous electric fields play an important role in embryogenesis, regeneration, and wound repair and previous studies have shown that many populations of cells, leukocytes, fibroblasts, epithelial cells, and endothelial cells, exhibit directed migration in response to electric fields. As regenerative therapies continue to explore ways to control mesenchymal progenitor cells to recreate desirable tissues, it is increasingly necessary to characterize the vast nature of biological responses imposed by physical phenomena. Murine adipose-derived stromal cells (mASCs) migrated toward the cathode in direct current (DC) fields of physiologic strength and show a dose dependence of migration rate to stronger fields. Electric fields also caused mASCs to orient perpendicularly to the field vector and elicited a transient increase in cytosolic calcium. Additionally, their galvanotactic response appears to share classic chemotactic signaling pathways that are involved in the migration of other cell types. Galvanotaxis is one predominant result of electric fields on mASCs and it may be exploited to engineer adult stem cell concentrations and locations within implanted grafts or toward sites of wound repair. Copyright (c) 2010 Elsevier Inc. All rights reserved.

  14. Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways.

    PubMed

    Yoshihara, Shigemi; Morimoto, Hiroshi; Ohori, Makoto; Yamada, Yumi; Abe, Toshio; Arisaka, Osamu

    2005-09-01

    Although neurogenic inflammation via the activation of C fibers in the airway must have an important role in the pathogenesis of asthma, their regulatory mechanism remains uncertain. The pharmacological profiles of endogenous cannabinoid receptor agonists on the activation of C fibers in airway tissues were investigated and the mechanisms how cannabinoids regulate airway inflammatory reactions were clarified. The effects of endogenous cannabinoid receptor agonists on electrical field stimulation-induced bronchial smooth muscle contraction, capsaicin-induced bronchoconstriction and capsaicin-induced substance P release in guinea pig airway tissues were investigated. The influences of cannabinoid receptor antagonists and K+ channel blockers to the effects of cannabinoid receptor agonists on these respiratory reactions were examined. Both endogenous cannabinoid receptor agonists, anandamide and palmitoylethanolamide, inhibited electrical field stimulation-induced guinea pig bronchial smooth muscle contraction, but not neurokinin A-induced contraction. A cannabinoid CB2 antagonist, SR 144528, reduced the inhibitory effect of endogenous agonists, but not a cannabinoid CB1 antagonist, SR 141716A. Inhibitory effects of agonists were also reduced by the pretreatment of large conductance Ca2+ -activated K+ channel (maxi-K+ channel) blockers, iberiotoxin and charybdotoxin, but not by other K+ channel blockers, dendrotoxin or glibenclamide. Anandamide and palmitoylethanolamide blocked the capsaicin-induced release of substance P-like immunoreactivity from guinea pig airway tissues. Additionally, intravenous injection of palmitoylethanolamide dose-dependently inhibited capsaicin-induced guinea pig bronchoconstriction, but not neurokinin A-induced reaction. However, anandamide did not reduce capsaicin-induced guinea pig bronchoconstriction. These findings suggest that endogenous cannabinoid receptor agonists inhibit the activation of C fibers via cannabinoid CB2 receptors and maxi-K+ channels in guinea pig airways. Copyright (c) 2005 S. Karger AG, Basel.

  15. Electrical Stimulation for Wound-Healing: Simulation on the Effect of Electrode Configurations

    PubMed Central

    2017-01-01

    Endogenous electric field is known to play important roles in the wound-healing process, mainly through its effects on protein synthesis and cell migration. Many clinical studies have demonstrated that electrical stimulation (ES) with steady direct currents is beneficial to accelerating wound-healing, even though the underlying mechanisms remain unclear. In the present study, a three-dimensional finite element wound model was built to optimize the electrode configuration in ES. Four layers of the skin, stratum corneum, epidermis, dermis, and subcutis, with defined thickness and electrical properties were modeled. The main goal was to evaluate the distributions of exogenous electric fields delivered with direct current (DC) stimulation using different electrode configurations such as sizes and positions. Based on the results, some guidelines were obtained in designing the electrode configuration for applications of clinical ES. PMID:28497054

  16. The Role of Direct Current Electric Field-Guided Stem Cell Migration in Neural Regeneration.

    PubMed

    Yao, Li; Li, Yongchao

    2016-06-01

    Effective directional axonal growth and neural cell migration are crucial in the neural regeneration of the central nervous system (CNS). Endogenous currents have been detected in many developing nervous systems. Experiments have demonstrated that applied direct current (DC) electric fields (EFs) can guide axonal growth in vitro, and attempts have been made to enhance the regrowth of damaged spinal cord axons using DC EFs in in vivo experiments. Recent work has revealed that the migration of stem cells and stem cell-derived neural cells can be guided by DC EFs. These studies have raised the possibility that endogenous and applied DC EFs can be used to direct neural tissue regeneration. Although the mechanism of EF-directed axonal growth and cell migration has not been fully understood, studies have shown that the polarization of cell membrane proteins and the activation of intracellular signaling molecules are involved in the process. The application of EFs is a promising biotechnology for regeneration of the CNS.

  17. Polarizing intestinal epithelial cells electrically through Ror2

    PubMed Central

    Cao, Lin; McCaig, Colin D.; Scott, Roderick H.; Zhao, Siwei; Milne, Gillian; Clevers, Hans; Zhao, Min; Pu, Jin

    2014-01-01

    ABSTRACT The apicobasal polarity of enterocytes determines where the brush border membrane (apical membrane) will form, but how this apical membrane faces the lumen is not well understood. The electrical signal across the epithelium could serve as a coordinating cue, orienting and polarizing enterocytes. Here, we show that applying a physiological electric field to intestinal epithelial cells, to mimic the natural electric field created by the transepithelial potential difference, polarized phosphorylation of the actin-binding protein ezrin, increased expression of intestinal alkaline phosphatase (ALPI, a differentiation marker) and remodeled the actin cytoskeleton selectively on the cathode side. In addition, an applied electric field also activated ERK1/2 and LKB1 (also known as STK11), key molecules in apical membrane formation. Disruption of the tyrosine protein kinase transmembrane receptor Ror2 suppressed activation of ERK1/2 and LKB1 significantly, and subsequently inhibited apical membrane formation in enterocytes. Our findings indicate that the endogenous electric field created by the transepithelial potential difference might act as an essential coordinating signal for apical membrane formation at a tissue level, through activation of LKB1 mediated by Ror2–ERK signaling. PMID:24928904

  18. Endogenous electromagnetic fields in plant leaves: a new hypothesis for vascular pattern formation.

    PubMed

    Pietak, Alexis Mari

    2011-06-01

    Electromagnetic (EM) phenomena have long been implicated in biological development, but few detailed, practical mechanisms have been put forth to connect electromagnetism with morphogenetic processes. This work describes a new hypothesis for plant leaf veination, whereby an endogenous electric field forming as a result of a coherent Frohlich process, and corresponding to an EM resonant mode of the developing leaf structure, is capable of instigating leaf vascularisation. In order to test the feasibility of this hypothesis, a three-dimensional, EM finite-element model (FEM) of a leaf primordium was constructed to determine if suitable resonant modes were physically possible for geometric and physical parameters similar to those of developing leaf tissue. Using the FEM model, resonant EM modes with patterns of relevance to developing leaf vein modalities were detected. On account of the existence of shared geometric signatures in a leaf's vascular pattern and the electric field component of EM resonant modes supported by a developing leaf structure, further theoretical and experimental investigations are warranted. Significantly, this hypothesis is not limited to leaf vascular patterning, but may be applicable to a variety of morphogenetic phenomena in a number of living systems.

  19. Electric polarization and the viability of living systems: ion cyclotron resonance-like interactions.

    PubMed

    Liboff, A R

    2009-01-01

    Wellness can be described in physical terms as a state that is a function of the organism's electric polarization vector P(r, t). One can alter P by invasive application of electric fields or by non invasive external pulsed magnetic fields (PMF) or ion cyclotron resonance (ICR)-like combinations of static and sinusoidal magnetic fields. Changes in human (total) body bioimpedance are significantly altered during exposure to ICR magnetic field combinations. The conductivities of polar amino acids in solution exhibit sharp discontinuities at ICR magnetic fields tuned to the specific charge to mass ratio of the amino acid. It has been reported that protein peptide bonds are broken by such amino acid ICR fields. Remarkably, some of these effects are only found at ultra-low AC magnetic intensities, on the order of .05 muT. This is approximately 10(3) below accepted levels determined by engineering estimates. Such strikingly low magnetic intensities imply the existence of physically equivalent endogenous weak electric field oscillations. These observations not only make claims related to electromagnetic pollution more credible but also provide a basis for future electromagnetic applications in medicine. They also reinforce the notion that physical factors acting to influence the electric polarization in living organisms play a key role in biology.

  20. Transcranial Electrical Currents to Probe EEG Brain Rhythms and Memory Consolidation during Sleep in Humans

    PubMed Central

    Marshall, Lisa; Kirov, Roumen; Brade, Julian; Mölle, Matthias; Born, Jan

    2011-01-01

    Previously the application of a weak electric anodal current oscillating with a frequency of the sleep slow oscillation (∼0.75 Hz) during non-rapid eye movement sleep (NonREM) sleep boosted endogenous slow oscillation activity and enhanced sleep-associated memory consolidation. The slow oscillations occurring during NonREM sleep and theta oscillations present during REM sleep have been considered of critical relevance for memory formation. Here transcranial direct current stimulation (tDCS) oscillating at 5 Hz, i.e., within the theta frequency range (theta-tDCS) is applied during NonREM and REM sleep. Theta-tDCS during NonREM sleep produced a global decrease in slow oscillatory activity conjoint with a local reduction of frontal slow EEG spindle power (8–12 Hz) and a decrement in consolidation of declarative memory, underlining the relevance of these cortical oscillations for sleep-dependent memory consolidation. In contrast, during REM sleep theta-tDCS appears to increase global gamma (25–45 Hz) activity, indicating a clear brain state-dependency of theta-tDCS. More generally, results demonstrate the suitability of oscillating-tDCS as a tool to analyze functions of endogenous EEG rhythms and underlying endogenous electric fields as well as the interactions between EEG rhythms of different frequencies. PMID:21340034

  1. Can Neural Activity Propagate by Endogenous Electrical Field?

    PubMed Central

    Qiu, Chen; Shivacharan, Rajat S.; Zhang, Mingming

    2015-01-01

    It is widely accepted that synaptic transmissions and gap junctions are the major governing mechanisms for signal traveling in the neural system. Yet, a group of neural waves, either physiological or pathological, share the same speed of ∼0.1 m/s without synaptic transmission or gap junctions, and this speed is not consistent with axonal conduction or ionic diffusion. The only explanation left is an electrical field effect. We tested the hypothesis that endogenous electric fields are sufficient to explain the propagation with in silico and in vitro experiments. Simulation results show that field effects alone can indeed mediate propagation across layers of neurons with speeds of 0.12 ± 0.09 m/s with pathological kinetics, and 0.11 ± 0.03 m/s with physiologic kinetics, both generating weak field amplitudes of ∼2–6 mV/mm. Further, the model predicted that propagation speed values are inversely proportional to the cell-to-cell distances, but do not significantly change with extracellular resistivity, membrane capacitance, or membrane resistance. In vitro recordings in mice hippocampi produced similar speeds (0.10 ± 0.03 m/s) and field amplitudes (2.5–5 mV/mm), and by applying a blocking field, the propagation speed was greatly reduced. Finally, osmolarity experiments confirmed the model's prediction that cell-to-cell distance inversely affects propagation speed. Together, these results show that despite their weak amplitude, electric fields can be solely responsible for spike propagation at ∼0.1 m/s. This phenomenon could be important to explain the slow propagation of epileptic activity and other normal propagations at similar speeds. SIGNIFICANCE STATEMENT Neural activity (waves or spikes) can propagate using well documented mechanisms such as synaptic transmission, gap junctions, or diffusion. However, the purpose of this paper is to provide an explanation for experimental data showing that neural signals can propagate by means other than synaptic transmission, gap junction, or diffusion. The results indicate that electric fields (ephaptic effects) are capable of mediating propagation of self-regenerating neural waves. This novel mechanism coupling cell-by-volume conduction could be involved in other types of propagating neural signals, such as slow-wave sleep, sharp hippocampal waves, theta waves, or seizures. PMID:26631463

  2. Electro-Acoustic Behavior of the Mitotic Spindle: A Semi-Classical Coarse-Grained Model

    PubMed Central

    Havelka, Daniel; Kučera, Ondřej; Deriu, Marco A.; Cifra, Michal

    2014-01-01

    The regulation of chromosome separation during mitosis is not fully understood yet. Microtubules forming mitotic spindles are targets of treatment strategies which are aimed at (i) the triggering of the apoptosis or (ii) the interruption of uncontrolled cell division. Despite these facts, only few physical models relating to the dynamics of mitotic spindles exist up to now. In this paper, we present the first electromechanical model which enables calculation of the electromagnetic field coupled to acoustic vibrations of the mitotic spindle. This electromagnetic field originates from the electrical polarity of microtubules which form the mitotic spindle. The model is based on the approximation of resonantly vibrating microtubules by a network of oscillating electric dipoles. Our computational results predict the existence of a rapidly changing electric field which is generated by either driven or endogenous vibrations of the mitotic spindle. For certain values of parameters, the intensity of the electric field and its gradient reach values which may exert a not-inconsiderable force on chromosomes which are aligned in the spindle midzone. Our model may describe possible mechanisms of the effects of ultra-short electrical and mechanical pulses on dividing cells—a strategy used in novel methods for cancer treatment. PMID:24497952

  3. Airway epithelial wounds in rhesus monkey generate ionic currents that guide cell migration to promote healing

    PubMed Central

    Sun, Yao-Hui; Reid, Brian; Fontaine, Justin H.; Miller, Lisa A.; Hyde, Dallas M.; Mogilner, Alex

    2011-01-01

    Damage to the respiratory epithelium is one of the most critical steps to many life-threatening diseases, such as acute respiratory distress syndrome and chronic obstructive pulmonary disease. The mechanisms underlying repair of the damaged epithelium have not yet been fully elucidated. Here we provide experimental evidence suggesting a novel mechanism for wound repair: endogenous electric currents. It is known that the airway epithelium maintains a voltage difference referred to as the transepithelial potential. Using a noninvasive vibrating probe, we demonstrate that wounds in the epithelium of trachea from rhesus monkeys generate significant outward electric currents. A small slit wound produced an outward current (1.59 μA/cm2), which could be enhanced (nearly doubled) by the ion transport stimulator aminophylline. In addition, inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) with CFTR(Inh)-172 significantly reduced wound currents (0.17 μA/cm2), implicating an important role of ion transporters in wound induced electric potentials. Time-lapse video microscopy showed that applied electric fields (EFs) induced robust directional migration of primary tracheobronchial epithelial cells from rhesus monkeys, towards the cathode, with a threshold of <23 mV/mm. Reversal of the field polarity induced cell migration towards the new cathode. We further demonstrate that application of an EF promoted wound healing in a monolayer wound healing assay. Our results suggest that endogenous electric currents at sites of tracheal epithelial injury may direct cell migration, which could benefit restitution of damaged airway mucosa. Manipulation of ion transport may lead to novel therapeutic approaches to repair damaged respiratory epithelium. PMID:21719726

  4. Computationally efficient simulation of electrical activity at cell membranes interacting with self-generated and externally imposed electric fields

    NASA Astrophysics Data System (ADS)

    Agudelo-Toro, Andres; Neef, Andreas

    2013-04-01

    Objective. We present a computational method that implements a reduced set of Maxwell's equations to allow simulation of cells under realistic conditions: sub-micron cell morphology, a conductive non-homogeneous space and various ion channel properties and distributions. Approach. While a reduced set of Maxwell's equations can be used to couple membrane currents to extra- and intracellular potentials, this approach is rarely taken, most likely because adequate computational tools are missing. By using these equations, and introducing an implicit solver, numerical stability is attained even with large time steps. The time steps are limited only by the time development of the membrane potentials. Main results. This method allows simulation times of tens of minutes instead of weeks, even for complex problems. The extracellular fields are accurately represented, including secondary fields, which originate at inhomogeneities of the extracellular space and can reach several millivolts. We present a set of instructive examples that show how this method can be used to obtain reference solutions for problems, which might not be accurately captured by the traditional approaches. This includes the simulation of realistic magnitudes of extracellular action potential signals in restricted extracellular space. Significance. The electric activity of neurons creates extracellular potentials. Recent findings show that these endogenous fields act back onto the neurons, contributing to the synchronization of population activity. The influence of endogenous fields is also relevant for understanding therapeutic approaches such as transcranial direct current, transcranial magnetic and deep brain stimulation. The mutual interaction between fields and membrane currents is not captured by today's concepts of cellular electrophysiology, including the commonly used activation function, as those concepts are based on isolated membranes in an infinite, isopotential extracellular space. The presented tool makes simulations with detailed morphology and implicit interactions of currents and fields available to the electrophysiology community.

  5. Enkephalinase inhibitor potentiates substance P- and electrically induced contraction in ferret trachea.

    PubMed

    Sekizawa, K; Tamaoki, J; Nadel, J A; Borson, D B

    1987-10-01

    To determine the role of endogenous enkephalinase (EC 3.4.24.11) in regulating peptide-induced contraction of airway smooth muscle, we studied the effect of the enkephalinase inhibitor, leucine-thiorphan (Leu-thiorphan), on responses of isolated ferret tracheal smooth muscle segments to substance P (SP) and to electrical field stimulation (EFS). Leu-thiorphan shifted the dose-response curve to SP to lower concentrations. Atropine or the SP antagonist [D-Pro2,D-Trp7,9]SP significantly inhibited SP-induced contractions in the presence of Leu-thiorphan. Leu-thiorphan increased the contractile responses to EFS dose dependently, an effect that was significantly inhibited by the SP antagonist [D-Pro2,D-Trp7,9]SP. SP, in a concentration that did not cause contraction, increased the contractile responses to EFS. This effect was augmented by Leu-thiorphan dose dependently and was not inhibited by hexamethonium or by phentolamine but was inhibited by atropine. Because contractile responses to acetylcholine were not significantly affected by SP or by Leu-thiorphan, the potentiating effects of SP were probably on presynaptic-postganglionic cholinergic neurotransmission. Captopril, bestatin, or leupeptin did not augment contractions, suggesting that enkephalinase was responsible for the effects. These results suggest that endogenous tachykinins modulate smooth muscle contraction and endogenous enkephalinase modulates contractions produced by endogenous or exogenous tachykinins and tachykinin-induced facilitation of cholinergic neurotransmission.

  6. Quality stability and sensory attributes of apple juice processed by thermosonication, pulsed electric field and thermal processing.

    PubMed

    Sulaiman, Alifdalino; Farid, Mohammed; Silva, Filipa Vm

    2017-04-01

    Worldwide, apple juice is the second most popular juice, after orange juice. It is susceptible to enzymatic browning spoilage by polyphenoloxidase, an endogenous enzyme. In this study, Royal Gala apple juice was treated by thermosonication (TS: 1.3 W/mL, 58 ℃, 10 min), pulsed electric field (PEF: 24.8 kV/cm, 60 pulses, 169 µs treatment time, 53.8 ℃) and heat (75 ℃, 20 min) and stored at 3.0 ℃ and 20.0 ℃ for 30 days. A sensory analysis was carried out after processing. The polyphenoloxidase activity, antioxidant activity and total color difference of the apple juice were determined before and after processing and during storage. The sensory analysis revealed that thermosonication and pulsed electric field juices tasted differently from the thermally treated juice. Apart from the pulsed electric field apple juice stored at room temperature, the processed juice was stable during storage, since the pH and soluble solids remained constant and fermentation was not observed. Polyphenoloxidase did not reactivate during storage. Along storage, the juices' antioxidant activity decreased and total color difference increased (up to 6.8). While the antioxidant activity increased from 86 to 103% with thermosonication and was retained after pulsed electric field, thermal processing reduced it to 67%. The processing increased the total color difference slightly. No differences in the total color difference of the juices processed by the three methods were registered after storage. Thermosonication and pulsed electric field could possibly be a better alternative to thermal preservation of apple juice, but refrigerated storage is recommended for pulsed electric field apple juice.

  7. Propagation of Epileptiform Activity Can Be Independent of Synaptic Transmission, Gap Junctions, or Diffusion and Is Consistent with Electrical Field Transmission

    PubMed Central

    Zhang, Mingming; Ladas, Thomas P.; Qiu, Chen; Shivacharan, Rajat S.; Gonzalez-Reyes, Luis E.

    2014-01-01

    The propagation of activity in neural tissue is generally associated with synaptic transmission, but epileptiform activity in the hippocampus can propagate with or without synaptic transmission at a speed of ∼0.1 m/s. This suggests an underlying common nonsynaptic mechanism for propagation. To study this mechanism, we developed a novel unfolded hippocampus preparation, from CD1 mice of either sex, which preserves the transverse and longitudinal connections and recorded activity with a penetrating microelectrode array. Experiments using synaptic transmission and gap junction blockers indicated that longitudinal propagation is independent of chemical or electrical synaptic transmission. Propagation speeds of 0.1 m/s are not compatible with ionic diffusion or pure axonal conduction. The only other means of communication between neurons is through electric fields. Computer simulations revealed that activity can indeed propagate from cell to cell solely through field effects. These results point to an unexpected propagation mechanism for neural activity in the hippocampus involving endogenous field effect transmission. PMID:24453330

  8. A galvanotaxis assay for analysis of neural precursor cell migration kinetics in an externally applied direct current electric field.

    PubMed

    Babona-Pilipos, Robart; Popovic, Milos R; Morshead, Cindi M

    2012-10-13

    The discovery of neural stem and progenitor cells (collectively termed neural precursor cells) (NPCs) in the adult mammalian brain has led to a body of research aimed at utilizing the multipotent and proliferative properties of these cells for the development of neuroregenerative strategies. A critical step for the success of such strategies is the mobilization of NPCs toward a lesion site following exogenous transplantation or to enhance the response of the endogenous precursors that are found in the periventricular region of the CNS. Accordingly, it is essential to understand the mechanisms that promote, guide, and enhance NPC migration. Our work focuses on the utilization of direct current electric fields (dcEFs) to promote and direct NPC migration - a phenomenon known as galvanotaxis. Endogenous physiological electric fields function as critical cues for cell migration during normal development and wound repair. Pharmacological disruption of the trans-neural tube potential in axolotl embryos causes severe developmental malformations(1). In the context of wound healing, the rate of repair of wounded cornea is directly correlated with the magnitude of the epithelial wound potential that arises after injury, as shown by pharmacological enhancement or disruption of this dcEF(2-3). We have demonstrated that adult subependymal NPCs undergo rapid and directed cathodal migration in vitro when exposed to an externally applied dcEF. In this protocol we describe our lab's techniques for creating a simple and effective galvanotaxis assay for high-resolution, long-term observation of directed cell body translocation (migration) on a single-cell level. This assay would be suitable for investigating the mechanisms that regulate dcEF transduction into cellular motility through the use of transgenic or knockout mice, short interfering RNA, or specific receptor agonists/antagonists.

  9. Ionic components of electric current at rat corneal wounds.

    PubMed

    Vieira, Ana Carolina; Reid, Brian; Cao, Lin; Mannis, Mark J; Schwab, Ivan R; Zhao, Min

    2011-02-25

    Endogenous electric fields and currents occur naturally at wounds and are a strong signal guiding cell migration into the wound to promote healing. Many cells involved in wound healing respond to small physiological electric fields in vitro. It has long been assumed that wound electric fields are produced by passive ion leakage from damaged tissue. Could these fields be actively maintained and regulated as an active wound response? What are the molecular, ionic and cellular mechanisms underlying the wound electric currents? Using rat cornea wounds as a model, we measured the dynamic timecourses of individual ion fluxes with ion-selective probes. We also examined chloride channel expression before and after wounding. After wounding, Ca(2+) efflux increased steadily whereas K(+) showed an initial large efflux which rapidly decreased. Surprisingly, Na(+) flux at wounds was inward. A most significant observation was a persistent large influx of Cl(-), which had a time course similar to the net wound electric currents we have measured previously. Fixation of the tissues abolished ion fluxes. Pharmacological agents which stimulate ion transport significantly increased flux of Cl(-), Na(+) and K(+). Injury to the cornea caused significant changes in distribution and expression of Cl(-) channel CLC2. These data suggest that the outward electric currents occurring naturally at corneal wounds are carried mainly by a large influx of chloride ions, and in part by effluxes of calcium and potassium ions. Ca(2+) and Cl(-) fluxes appear to be mainly actively regulated, while K(+) flux appears to be largely due to leakage. The dynamic changes of electric currents and specific ion fluxes after wounding suggest that electrical signaling is an active response to injury and offers potential novel approaches to modulate wound healing, for example eye-drops targeting ion transport to aid in the challenging management of non-healing corneal ulcers.

  10. Endogenous electric fields as guiding cue for cell migration

    PubMed Central

    Funk, Richard H. W.

    2015-01-01

    This review covers two topics: (1) “membrane potential of low magnitude and related electric fields (bioelectricity)” and (2) “cell migration under the guiding cue of electric fields (EF).”Membrane potentials for this “bioelectricity” arise from the segregation of charges by special molecular machines (pumps, transporters, ion channels) situated within the plasma membrane of each cell type (including eukaryotic non-neural animal cells). The arising patterns of ion gradients direct many cell- and molecular biological processes such as embryogenesis, wound healing, regeneration. Furthermore, EF are important as guiding cues for cell migration and are often overriding chemical or topographic cues. In osteoblasts, for instance, the directional information of EF is captured by charged transporters on the cell membrane and transferred into signaling mechanisms that modulate the cytoskeleton and motor proteins. This results in a persistent directional migration along an EF guiding cue. As an outlook, we discuss questions concerning the fluctuation of EF and the frequencies and mapping of the “electric” interior of the cell. Another exciting topic for further research is the modeling of field concepts for such distant, non-chemical cellular interactions. PMID:26029113

  11. Cognitive and Neural Bases of Skilled Performance

    DTIC Science & Technology

    1990-08-09

    torso. The only significant source of noise was a slow variation of the ambient field, which produces a drift of the baseline. The first depended upon...brief survey. Scand. J. of Psychology, Suppl. 1:170-174, 1982. [25] S. A. Hillyard, R. F. Hink , V. L. Schwent, and T. W. Picton. Electrical signs of...Okada, L. Kaufman, and S. J. Williamson. The hippocampal formation as a source of the slow endogenous potentials. Electroencepk. Clin. Neurophysiol

  12. Toward a convergence of regenerative medicine, rehabilitation, and neuroprosthetics.

    PubMed

    Aravamudhan, Shyam; Bellamkonda, Ravi V

    2011-11-01

    No effective therapeutic interventions exist for severe neural pathologies, despite significant advances in regenerative medicine, rehabilitation, and neuroprosthetics. Our current hypothesis is that a specific combination of tissue engineering, pharmacology, cell replacement, drug delivery, and electrical stimulation, together with plasticity-promoting and locomotor training (neurorehabilitation) is necessary to interact synergistically in order to activate and enable all damaged circuits. We postulate that various convergent themes exist among the different therapeutic fields. Therefore, the objective of this review is to highlight the convergent themes, which we believe have a common goal of restoring function after neural damage. The convergent themes discussed in this review include modulation of inflammation and secondary damage, encouraging endogenous repair/regeneration (using scaffolds, cell transplantation, and drug delivery), application of electrical fields to modulate healing and/or activity, and finally modulation of plasticity.

  13. Continuous exposure to low amplitude extremely low frequency electrical fields characterizing the vascular streaming potential alters elastin accumulation in vascular smooth muscle cells.

    PubMed

    Bergethon, Peter R; Kindler, Dean D; Hallock, Kevin; Blease, Susan; Toselli, Paul

    2013-07-01

    In normal development and pathology, the vascular system depends on complex interactions between cellular elements, biochemical molecules, and physical forces. The electrokinetic vascular streaming potential (EVSP) is an endogenous extremely low frequency (ELF) electrical field resulting from blood flowing past the vessel wall. While generally unrecognized, it is a ubiquitous electrical biophysical force to which the vascular tree is exposed. Extracellular matrix elastin plays a central role in normal blood vessel function and in the development of atherosclerosis. It was hypothesized that ELF fields of low amplitude would alter elastin accumulation, supporting a link between the EVSP and the biology of vascular smooth muscle cells. Neonatal rat aortic smooth muscle cell cultures were exposed chronically to electrical fields characteristic of the EVSP. Extracellular protein accumulation, DNA content, and electron microscopic (EM) evaluation were performed after 2 weeks of exposure. Stimulated cultures showed no significant change in cellular proliferation as measured by the DNA concentration. The per-DNA normalized protein in the extracellular matrix was unchanged while extracellular elastin accumulation decreased 38% on average. EM analysis showed that the stimulated cells had a 2.85-fold increase in mitochondrial number. These results support the formulation that ELF fields are a potential factor in both normal vessel biology and in the pathogenesis of atherosclerotic diseases including heart disease, stroke, and peripheral vascular disease. Copyright © 2013 Wiley Periodicals, Inc.

  14. Ionic Components of Electric Current at Rat Corneal Wounds

    PubMed Central

    Cao, Lin; Mannis, Mark J.; Schwab, Ivan R.; Zhao, Min

    2011-01-01

    Background Endogenous electric fields and currents occur naturally at wounds and are a strong signal guiding cell migration into the wound to promote healing. Many cells involved in wound healing respond to small physiological electric fields in vitro. It has long been assumed that wound electric fields are produced by passive ion leakage from damaged tissue. Could these fields be actively maintained and regulated as an active wound response? What are the molecular, ionic and cellular mechanisms underlying the wound electric currents? Methodology/Principal Findings Using rat cornea wounds as a model, we measured the dynamic timecourses of individual ion fluxes with ion-selective probes. We also examined chloride channel expression before and after wounding. After wounding, Ca2+ efflux increased steadily whereas K+ showed an initial large efflux which rapidly decreased. Surprisingly, Na+ flux at wounds was inward. A most significant observation was a persistent large influx of Cl−, which had a time course similar to the net wound electric currents we have measured previously. Fixation of the tissues abolished ion fluxes. Pharmacological agents which stimulate ion transport significantly increased flux of Cl−, Na+ and K+. Injury to the cornea caused significant changes in distribution and expression of Cl− channel CLC2. Conclusions/Significance These data suggest that the outward electric currents occurring naturally at corneal wounds are carried mainly by a large influx of chloride ions, and in part by effluxes of calcium and potassium ions. Ca2+ and Cl− fluxes appear to be mainly actively regulated, while K+ flux appears to be largely due to leakage. The dynamic changes of electric currents and specific ion fluxes after wounding suggest that electrical signaling is an active response to injury and offers potential novel approaches to modulate wound healing, for example eye-drops targeting ion transport to aid in the challenging management of non-healing corneal ulcers. PMID:21364900

  15. Nanowires and Electrical Stimulation Synergistically Improve Functions of hiPSC Cardiac Spheroids.

    PubMed

    Richards, Dylan J; Tan, Yu; Coyle, Robert; Li, Yang; Xu, Ruoyu; Yeung, Nelson; Parker, Arran; Menick, Donald R; Tian, Bozhi; Mei, Ying

    2016-07-13

    The advancement of human induced pluripotent stem-cell-derived cardiomyocyte (hiPSC-CM) technology has shown promising potential to provide a patient-specific, regenerative cell therapy strategy to treat cardiovascular disease. Despite the progress, the unspecific, underdeveloped phenotype of hiPSC-CMs has shown arrhythmogenic risk and limited functional improvements after transplantation. To address this, tissue engineering strategies have utilized both exogenous and endogenous stimuli to accelerate the development of hiPSC-CMs. Exogenous electrical stimulation provides a biomimetic pacemaker-like stimuli that has been shown to advance the electrical properties of tissue engineered cardiac constructs. Recently, we demonstrated that the incorporation of electrically conductive silicon nanowires to hiPSC cardiac spheroids led to advanced structural and functional development of hiPSC-CMs by improving the endogenous electrical microenvironment. Here, we reasoned that the enhanced endogenous electrical microenvironment of nanowired hiPSC cardiac spheroids would synergize with exogenous electrical stimulation to further advance the functional development of nanowired hiPSC cardiac spheroids. For the first time, we report that the combination of nanowires and electrical stimulation enhanced cell-cell junction formation, improved development of contractile machinery, and led to a significant decrease in the spontaneous beat rate of hiPSC cardiac spheroids. The advancements made here address critical challenges for the use of hiPSC-CMs in cardiac developmental and translational research and provide an advanced cell delivery vehicle for the next generation of cardiac repair.

  16. Electric Signals Regulate the Directional Migration of Oligodendrocyte Progenitor Cells (OPCs) via β1 Integrin.

    PubMed

    Zhu, Bangfu; Nicholls, Matthew; Gu, Yu; Zhang, Gaofeng; Zhao, Chao; Franklin, Robin J M; Song, Bing

    2016-11-22

    The guided migration of neural cells is essential for repair in the central nervous system (CNS). Oligodendrocyte progenitor cells (OPCs) will normally migrate towards an injury site to re-sheath demyelinated axons; however the mechanisms underlying this process are not well understood. Endogenous electric fields (EFs) are known to influence cell migration in vivo, and have been utilised in this study to direct the migration of OPCs isolated from neonatal Sprague-Dawley rats. The OPCs were exposed to physiological levels of electrical stimulation, and displayed a marked electrotactic response that was dependent on β1 integrin, one of the key subunits of integrin receptors. We also observed that F-actin, an important component of the cytoskeleton, was re-distributed towards the leading edge of the migrating cells, and that this asymmetric rearrangement was associated with β1 integrin function.

  17. Age-related changes in functional NANC innervation with VIP and substance P in the jejunum of Lewis rats.

    PubMed

    Kasparek, Michael S; Fatima, Javairiah; Iqbal, Corey W; Duenes, Judith A; Sarr, Michael G

    2009-12-03

    Age-related changes in non-adrenergic, non-cholinergic (NANC) neurotransmission might contribute to differences in gastrointestinal motility. Our aim was to determine age-related changes in functional innervation with vasoactive intestinal polypeptide (VIP) and substance P (Sub P) in rat jejunum. We hypothesized that maturation causes changes in neurotransmission with these two neuropeptides. Longitudinal and circular jejunal muscle strips from young (3 months) and middle-aged (15 months) rats (total: 24 rats) were studied; the response to exogenous VIP and Sub P and the effect of their endogenous release from the enteric nervous system during electrical field stimulation (EFS) were evaluated. In longitudinal muscle, response to exogenous VIP and endogenously released VIP during EFS were increased in middle-aged rats, while the effect of endogenously released Sub P was decreased. In the circular muscle, the response to endogenously released VIP was increased in middle-aged rats, while the effects of exogenous VIP and endogenously released Sub P were unchanged. Response to exogenous Sub P was unaffected by maturation in both muscle layers. Spontaneous contractile activity was increased in the longitudinal and circular muscle of the older rats. In the jejunum of middle-aged rats, participation of VIP in functional NANC innervation was increased, while functional innervation with Sub P was decreased. These changes in the balance of inhibitory and excitatory neurotransmission occur during the year of maturation in rats and demonstrate an age-dependant plasticity of neuromuscular bowel function.

  18. Influence of Electric Fields on Biofouling of Carbonaceous Electrodes.

    PubMed

    Pandit, Soumya; Shanbhag, Sneha; Mauter, Meagan; Oren, Yoram; Herzberg, Moshe

    2017-09-05

    Biofouling commonly occurs on carbonaceous capacitive deionization electrodes in the process of treating natural waters. Although previous work reported the effect of electric fields on bacterial mortality for a variety of medical and engineered applications, the effect of electrode surface properties and the magnitude and polarity of applied electric fields on biofilm development has not been comprehensively investigated. This paper studies the formation of a Pseudomonas aeruginosa biofilm on a Papyex graphite (PA) and a carbon aerogel (CA) in the presence and the absence of an electric field. The experiments were conducted using a two-electrode flow cell with a voltage window of ±0.9 V. The CA was less susceptible to biofilm formation compared to the PA due to its lower surface roughness, lower hydrophobicity, and significant antimicrobial properties. For both positive and negative applied potentials, we observed an inverse relationship between biofilm formation and the magnitude of the applied potential. The effect is particularly strong for the CA electrodes and may be a result of cumulative effects between material toxicity and the stress experienced by cells at high applied potentials. Under the applied potentials for both electrodes, high production of endogenous reactive oxygen species (ROS) was indicative of bacterial stress. For both electrodes, the elevated specific ROS activity was lowest for the open circuit potential condition, elevated when cathodically and anodically polarized, and highest for the ±0.9 V cases. These high applied potentials are believed to affect the redox potential across the cell membrane and disrupt redox homeostasis, thereby inhibiting bacterial growth.

  19. The Electrical Response to Injury: Molecular Mechanisms and Wound Healing

    PubMed Central

    Reid, Brian; Zhao, Min

    2014-01-01

    Significance: Natural, endogenous electric fields (EFs) and currents arise spontaneously after wounding of many tissues, especially epithelia, and are necessary for normal healing. This wound electrical activity is a long-lasting and regulated response. Enhancing or inhibiting this electrical activity increases or decreases wound healing, respectively. Cells that are responsible for wound closure such as corneal epithelial cells or skin keratinocytes migrate directionally in EFs of physiological magnitude. However, the mechanisms of how the wound electrical response is initiated and regulated remain unclear. Recent Advances: Wound EFs and currents appear to arise by ion channel up-regulation and redistribution, which are perhaps triggered by an intracellular calcium wave or cell depolarization. We discuss the possibility of stimulation of wound healing via pharmacological enhancement of the wound electric signal by stimulation of ion pumping. Critical Issues: Chronic wounds are a major problem in the elderly and diabetic patient. Any strategy to stimulate wound healing in these patients is desirable. Applying electrical stimulation directly is problematic, but pharmacological enhancement of the wound signal may be a promising strategy. Future Directions: Understanding the molecular regulation of wound electric signals may reveal some fundamental mechanisms in wound healing. Manipulating fluxes of ions and electric currents at wounds might offer new approaches to achieve better wound healing and to heal chronic wounds. PMID:24761358

  20. Simulations of centriole of polarized centrosome as a monopole antenna in immune and viral synapses.

    PubMed

    Dvorak, Josef; Melichar, Bohuslav; Filipova, Alzbeta; Grimova, Jana; Grimova, Nela; Rozsypalova, Aneta; Buka, David; Voboril, Rene; Zapletal, Radek; Buchler, Tomas; Richter, Igor; Buka, David

    2018-01-01

    The immune synapse (IS) is a temporary interface between an antigen-presenting cell and an effector lymphocyte. Viral synapse is a molecularly organized cellular junction that is structurally similar to the IS. Primary cilium is considered as a functional homologue of the IS due to the morphological and functional similarities in architecture between both micotubule structures. It has been hypothesized that endogenous electromagnetic field in the cell is generated by a unique cooperating system between mitochondria and microtubules. We are extending this prior hypothesis of the endogenous electromagnetic field in the cell postulating that polarized centriole in immune and viral synapse could serve as a monopole antenna. This is an addition to our hypothesis that primary cilium could serve as a monopole antenna. We simulated the distribution of electric field of centriole of polarized centrosome as a monopole antenna in immune and viral synapse. Very weak electromagnetic field of polarized centriole of CD8+ T lymphocyte in IS can contribute to the transport of cytolytic granules into the attacked (cancer) cell. Analogically, very weak electromagnetic field of polarized centriole in viral synapse of infected CD4 cells can aid the transport of viruses (human immunodeficiency virus) to non-infected CD4 cells. We hypothesized that healthy organisms need these monopole antennas. If, during the neoplastic transformation, healthy cells lose monopole antennas in form of primary cilia, the IS aims to replace them by monopole antennas of polarized centrioles in IS to restore homeostasis.

  1. Effect of endogenous tachykinins on neuro-effector transmission of vagal nerve in guinea-pig tracheal tissue.

    PubMed

    Aizawa, H; Miyazaki, N; Inoue, H; Ikeda, T; Shigematsu, N

    1990-01-01

    To elucidate the effect of endogenous tachykinins on neuro-effector transmission of vagal nerves, we performed in vitro experiments using guinea-pig tracheal smooth muscle. The subthreshold dose (the highest dose which did not induce any smooth muscle contraction) of capsaicin (10(-8) to 10(-7) M) increased the amplitudes of contractions evoked by electrical field stimulation (EFS) significantly, but not those by acetylcholine (ACh). The inhibitor of neutral endopeptidase, phosphoramidon (10(-7) to 10(-6) M), increased the contractions evoked by EFS significantly. The inhibitor of cholinesterase, physostigmine (10(-6) to 10(-5) M), induced smooth muscle contractions, but such contractions were inhibited by atropine, suggesting the spontaneous release of ACh from the vagal nerve terminals. The subthreshold dose of substance P or capsaicin increased the contractions evoked by physostigmine. These results indicated that endogenous tachykinins increase the spontaneous ACh release as well as the ACh release in response to vagal stimulation from the nerve terminals. Furthermore, it is suggested that the excitatory effects of the tachykinins on the vagal neuro-effector transmission may be modulated by neutral endopeptidase in the guinea pig.

  2. Functional electrical stimulation-facilitated proliferation and regeneration of neural precursor cells in the brains of rats with cerebral infarction

    PubMed Central

    Xiang, Yun; Liu, Huihua; Yan, Tiebin; Zhuang, Zhiqiang; Jin, Dongmei; Peng, Yuan

    2014-01-01

    Previous studies have shown that proliferation of endogenous neural precursor cells cannot alone compensate for the damage to neurons and axons. From the perspective of neural plasticity, we observed the effects of functional electrical stimulation treatment on endogenous neural precursor cell proliferation and expression of basic fibroblast growth factor and epidermal growth factor in the rat brain on the infarct side. Functional electrical stimulation was performed in rat models of acute middle cerebral artery occlusion. Simultaneously, we set up a placebo stimulation group and a sham-operated group. Immunohistochemical staining showed that, at 7 and 14 days, compared with the placebo group, the numbers of nestin (a neural precursor cell marker)-positive cells in the subgranular zone and subventricular zone were increased in the functional electrical stimulation treatment group. Western blot assays and reverse-transcription PCR showed that total protein levels and gene expression of epidermal growth factor and basic fibroblast growth factor were also upregulated on the infarct side. Prehensile traction test results showed that, at 14 days, prehension function of rats in the functional electrical stimulation group was significantly better than in the placebo group. These results suggest that functional electrical stimulation can promote endogenous neural precursor cell proliferation in the brains of acute cerebral infarction rats, enhance expression of basic fibroblast growth factor and epidermal growth factor, and improve the motor function of rats. PMID:25206808

  3. Thermal noise due to surface-charge effects within the Debye layer of endogenous structures in dendrites.

    PubMed

    Poznanski, Roman R

    2010-02-01

    An assumption commonly used in cable theory is revised by taking into account electrical amplification due to intracellular capacitive effects in passive dendritic cables. A generalized cable equation for a cylindrical volume representation of a dendritic segment is derived from Maxwell's equations under assumptions: (i) the electric-field polarization is restricted longitudinally along the cable length; (ii) extracellular isopotentiality; (iii) quasielectrostatic conditions; and (iv) homogeneous medium with constant conductivity and permittivity. The generalized cable equation is identical to Barenblatt's equation arising in the theory of infiltration in fissured strata with a known analytical solution expressed in terms of a definite integral involving a modified Bessel function and the solution to a linear one-dimensional classical cable equation. Its solution is used to determine the impact of thermal noise on voltage attenuation with distance at any particular time. A regular perturbation expansion for the membrane potential about the linear one-dimensional classical cable equation solution is derived in terms of a Green's function in order to describe the dynamics of free charge within the Debye layer of endogenous structures in passive dendritic cables. The asymptotic value of the first perturbative term is explicitly evaluated for small values of time to predict how the slowly fluctuating (in submillisecond range) electric field attributed to intracellular capacitive effects alters the amplitude of the membrane potential. It was found that capacitive effects are almost negligible for cables with electrotonic lengths L>0.5 , contributes up to 10% of the signal for cables with electrotonic lengths in the range between 0.25

  4. Biofield Physiology: A Framework for an Emerging Discipline

    PubMed Central

    Levin, Michael; McCraty, Rollin; Bat, Namuun; Ives, John A.; Lutgendorf, Susan K.; Oschman, James L.

    2015-01-01

    Biofield physiology is proposed as an overarching descriptor for the electromagnetic, biophotonic, and other types of spatially-distributed fields that living systems generate and respond to as integral aspects of cellular, tissue, and whole organism self-regulation and organization. Medical physiology, cell biology, and biophysics provide the framework within which evidence for biofields, their proposed receptors, and functions is presented. As such, biofields can be viewed as affecting physiological regulatory systems in a manner that complements the more familiar molecular-based mechanisms. Examples of clinically relevant biofields are the electrical and magnetic fields generated by arrays of heart cells and neurons that are detected, respectively, as electrocardiograms (ECGs) or magnetocardiograms (MCGs) and electroencephalograms (EEGs) or magnetoencephalograms (MEGs). At a basic physiology level, electromagnetic activity of neural assemblies appears to modulate neuronal synchronization and circadian rhythmicity. Numerous nonneural electrical fields have been detected and analyzed, including those arising from patterns of resting membrane potentials that guide development and regeneration, and from slowly-varying transepithelial direct current fields that initiate cellular responses to tissue damage. Another biofield phenomenon is the coherent, ultraweak photon emissions (UPE), detected from cell cultures and from the body surface. A physiological role for biophotons is consistent with observations that fluctuations in UPE correlate with cerebral blood flow, cerebral energy metabolism, and EEG activity. Biofield receptors are reviewed in 3 categories: molecular-level receptors, charge flux sites, and endogenously generated electric or electromagnetic fields. In summary, sufficient evidence has accrued to consider biofield physiology as a viable scientific discipline. Directions for future research are proposed. PMID:26665040

  5. Biofield Physiology: A Framework for an Emerging Discipline.

    PubMed

    Hammerschlag, Richard; Levin, Michael; McCraty, Rollin; Bat, Namuun; Ives, John A; Lutgendorf, Susan K; Oschman, James L

    2015-11-01

    Biofield physiology is proposed as an overarching descriptor for the electromagnetic, biophotonic, and other types of spatially-distributed fields that living systems generate and respond to as integral aspects of cellular, tissue, and whole organism self-regulation and organization. Medical physiology, cell biology, and biophysics provide the framework within which evidence for biofields, their proposed receptors, and functions is presented. As such, biofields can be viewed as affecting physiological regulatory systems in a manner that complements the more familiar molecular-based mechanisms. Examples of clinically relevant biofields are the electrical and magnetic fields generated by arrays of heart cells and neurons that are detected, respectively, as electrocardiograms (ECGs) or magnetocardiograms (MCGs) and electroencephalograms (EEGs) or magnetoencephalograms (MEGs). At a basic physiology level, electromagnetic activity of neural assemblies appears to modulate neuronal synchronization and circadian rhythmicity. Numerous nonneural electrical fields have been detected and analyzed, including those arising from patterns of resting membrane potentials that guide development and regeneration, and from slowly-varying transepithelial direct current fields that initiate cellular responses to tissue damage. Another biofield phenomenon is the coherent, ultraweak photon emissions (UPE), detected from cell cultures and from the body surface. A physiological role for biophotons is consistent with observations that fluctuations in UPE correlate with cerebral blood flow, cerebral energy metabolism, and EEG activity. Biofield receptors are reviewed in 3 categories: molecular-level receptors, charge flux sites, and endogenously generated electric or electromagnetic fields. In summary, sufficient evidence has accrued to consider biofield physiology as a viable scientific discipline. Directions for future research are proposed.

  6. Rats with decreased brain cholecystokinin levels show increased responsiveness to peripheral electrical stimulation-induced analgesia.

    PubMed

    Zhang, L X; Li, X L; Wang, L; Han, J S

    1997-01-16

    Using the P77PMC strain of rat, which is genetically prone to audiogenic seizures, and also has decreased levels of cholecystokinin (CCK), we examined the analgesic response to peripheral electrical stimulation, which is, in part, opiate-mediated. A number of studies have suggested that CCK may function as an antagonist to endogenous opiate effects. Therefore, we hypothesized that the P77PMC animals would show an enhanced analgesic response based on their decreased CCK levels producing a diminished endogenous opiate antagonism. We found that the analgesic effect on tail flick latency produced by 100 Hz peripheral electrical stimulation was more potent and longer lasting in P77PMC rats than in control rats. Moreover, the potency of the stimulation-produced analgesia correlated with the vulnerability to audiogenic seizures in these rats. We were able to block the peripheral electrical stimulation-induced analgesia (PSIA) using a cholecystokinin octapeptide (CCK-8) administered parenterally. Radioimmunoassay showed that the content of CCK-8 in cerebral cortex, hippocampus and periaqueductal gray was much lower in P77PMC rat than in controls. These results suggest that low CCK-8 content in the central nervous system of the P77PMC rats may be related to the high analgesic response to peripheral electrical stimulation, and further support the notion that CCK may be endogenous opiate antagonist.

  7. Computing by physical interaction in neurons.

    PubMed

    Aur, Dorian; Jog, Mandar; Poznanski, Roman R

    2011-12-01

    The electrodynamics of action potentials represents the fundamental level where information is integrated and processed in neurons. The Hodgkin-Huxley model cannot explain the non-stereotyped spatial charge density dynamics that occur during action potential propagation. Revealed in experiments as spike directivity, the non-uniform charge density dynamics within neurons carry meaningful information and suggest that fragments of information regarding our memories are endogenously stored in structural patterns at a molecular level and are revealed only during spiking activity. The main conceptual idea is that under the influence of electric fields, efficient computation by interaction occurs between charge densities embedded within molecular structures and the transient developed flow of electrical charges. This process of computation underlying electrical interactions and molecular mechanisms at the subcellular level is dissimilar from spiking neuron models that are completely devoid of physical interactions. Computation by interaction describes a more powerful continuous model of computation than the one that consists of discrete steps as represented in Turing machines.

  8. Electromagnetic homeostasis and the role of low-amplitude electromagnetic fields on life organization.

    PubMed

    De Ninno, Antonella; Pregnolato, Massimo

    2017-01-01

    The appearance of endogenous electromagnetic fields in biological systems is a widely debated issue in modern science. The electrophysiological fields have very tiny intensities and it can be inferred that they are rapidly decreasing with the distance from the generating structure, vanishing at very short distances. This makes very hard their detection using standard experimental methods. However, the existence of fast-moving charged particles in the macromolecules inside both intracellular and extracellular fluids may envisage the generation of localized electric currents as well as the presence of closed loops, which implies the existence of magnetic fields. Moreover, the whole set of oscillatory frequencies of various substances, enzymes, cell membranes, nucleic acids, bioelectrical phenomena generated by the electrical rhythm of coherent groups of cells, cell-to-cell communication among population of host bacteria, forms the increasingly complex hierarchies of electromagnetic signals of different frequencies which cover the living being and represent a fundamental information network controlling the cell metabolism. From this approach emerges the concept of electromagnetic homeostasis: that is, the capability of the human body to maintain the balance of highly complex electromagnetic interactions within, in spite of the external electromagnetic noisy environment. This concept may have an important impact on the actual definitions of heal and disease.

  9. Electrical stimulation of schwann cells promotes sustained increases in neurite outgrowth.

    PubMed

    Koppes, Abigail N; Nordberg, Andrea L; Paolillo, Gina M; Goodsell, Nicole M; Darwish, Haley A; Zhang, Linxia; Thompson, Deanna M

    2014-02-01

    Endogenous electric fields are instructive during embryogenesis by acting to direct cell migration, and postnatally, they can promote axonal growth after injury (McCaig 1991, Al-Majed 2000). However, the mechanisms for these changes are not well understood. Application of an appropriate electrical stimulus may increase the rate and success of nerve repair by directly promoting axonal growth. Previously, DC electrical stimulation at 50 mV/mm (1 mA, 8 h duration) was shown to promote neurite outgrowth and a more pronounced effect was observed if both peripheral glia (Schwann cells) and neurons were co-stimulated. If electrical stimulation is delivered to an injury site, both the neurons and all resident non-neuronal cells [e.g., Schwann cells, endothelial cells, fibroblasts] will be treated and this biophysical stimuli can influence axonal growth directly or indirectly via changes to the resident, non-neuronal cells. In this work, non-neuronal cells were electrically stimulated, and changes in morphology and neuro-supportive cells were evaluated. Schwann cell response (morphology and orientation) was examined after an 8 h stimulation over a range of DC fields (0-200 mV/mm, DC 1 mA), and changes in orientation were observed. Electrically prestimulating Schwann cells (50 mV/mm) promoted 30% more neurite outgrowth relative to co-stimulating both Schwann cells with neurons, suggesting that electrical stimulation modifies Schwann cell phenotype. Conditioned medium from the electrically prestimulated Schwann cells promoted a 20% increase in total neurite outgrowth and was sustained for 72 h poststimulation. An 11-fold increase in nerve growth factor but not brain-derived neurotrophic factor or glial-derived growth factor was found in the electrically prestimulated Schwann cell-conditioned medium. No significant changes in fibroblast or endothelial morphology and neuro-supportive behavior were observed poststimulation. Electrical stimulation is widely used in clinical settings; however, the rational application of this cue may directly impact and enhance neuro-supportive behavior, improving nerve repair.

  10. Lipid rafts sense and direct electric field-induced migration

    PubMed Central

    Lin, Bo-jian; Tsao, Shun-hao; Chen, Alex; Hu, Shu-Kai; Chao, Ling

    2017-01-01

    Endogenous electric fields (EFs) are involved in developmental regulation and wound healing. Although the phenomenon is known for more than a century, it is not clear how cells perceive the external EF. Membrane proteins, responding to electrophoretic and electroosmotic forces, have long been proposed as the sensing molecules. However, specific charge modification of surface proteins did not change cell migration motility nor directionality in EFs. Moreover, symmetric alternating current (AC) EF directs cell migration in a frequency-dependent manner. Due to their charge and ability to coalesce, glycolipids are therefore the likely primary EF sensor driving polarization of membrane proteins and intracellular signaling. We demonstrate that detergent-resistant membrane nanodomains, also known as lipid rafts, are the primary response element in EF sensing. The clustering and activation of caveolin and signaling proteins further stabilize raft structure and feed-forward downstream signaling events, such as rho and PI3K activation. Theoretical modeling supports the experimental results and predicts AC frequency-dependent cell and raft migration. Our results establish a fundamental mechanism for cell electrosensing and provide a role in lipid raft mechanotransduction. PMID:28739955

  11. Lipid rafts sense and direct electric field-induced migration.

    PubMed

    Lin, Bo-Jian; Tsao, Shun-Hao; Chen, Alex; Hu, Shu-Kai; Chao, Ling; Chao, Pen-Hsiu Grace

    2017-08-08

    Endogenous electric fields (EFs) are involved in developmental regulation and wound healing. Although the phenomenon is known for more than a century, it is not clear how cells perceive the external EF. Membrane proteins, responding to electrophoretic and electroosmotic forces, have long been proposed as the sensing molecules. However, specific charge modification of surface proteins did not change cell migration motility nor directionality in EFs. Moreover, symmetric alternating current (AC) EF directs cell migration in a frequency-dependent manner. Due to their charge and ability to coalesce, glycolipids are therefore the likely primary EF sensor driving polarization of membrane proteins and intracellular signaling. We demonstrate that detergent-resistant membrane nanodomains, also known as lipid rafts, are the primary response element in EF sensing. The clustering and activation of caveolin and signaling proteins further stabilize raft structure and feed-forward downstream signaling events, such as rho and PI3K activation. Theoretical modeling supports the experimental results and predicts AC frequency-dependent cell and raft migration. Our results establish a fundamental mechanism for cell electrosensing and provide a role in lipid raft mechanotransduction.

  12. Spontaneous and electrically modulated spatiotemporal dynamics of the neocortical slow oscillation and associated local fast activity.

    PubMed

    Greenberg, Anastasia; Dickson, Clayton T

    2013-12-01

    The neocortical slow oscillation (SO; ~1Hz) of non-REM sleep and anesthesia reflects synchronized network activity composed of alternating active and silent (ON/OFF) phases at the local network and cellular level. The SO itself shows self-organized spatiotemporal dynamics as it appears to originate at unique foci on each cycle and then propagates across the cortical surface. During sleep, this rhythm is relevant for neuroplastic processes mediating memory consolidation especially since its enhancement by slow, rhythmic electrical fields improves subsequent recall. However, the neurobiological mechanism by which spontaneous or enhanced SO activity might operate on memory traces is unknown. Here we show a series of original results, using cycle to cycle tracking across multiple neocortical sites in urethane anesthetized rats: The spontaneous spatiotemporal dynamics of the SO are complex, showing interfering propagation patterns in the anterior-to-posterior plane. These patterns compete for expression and tend to alternate following phase resets that take place during the silent OFF phase of the SO. Applying sinusoidal electrical field stimulation to the anterior pole of the cerebral cortex progressively entrained local field, gamma, and multi-unit activity at all sites, while disrupting the coordination of endogenous SO activity. Field stimulation also biased propagation in the anterior-to-posterior direction and more notably, enhanced the long-range gamma synchrony between cortical regions. These results are the first to show that changes to slow wave dynamics cause enhancements in high frequency cortico-cortical communication and provide mechanistic clues into how the SO is relevant for sleep-dependent memory consolidation. © 2013.

  13. The body electric 2.0: recent advances in developmental bioelectricity for regenerative and synthetic bioengineering.

    PubMed

    Mathews, Juanita; Levin, Michael

    2018-04-20

    Breakthroughs in biomedicine and synthetic bioengineering require predictive, rational control over anatomical structure and function. Recent successes in manipulating cellular and molecular hardware have not been matched by progress in understanding the patterning software implemented during embryogenesis and regeneration. A fundamental capability gap is driving desired changes in growth and form to address birth defects and traumatic injury. Here we review new tools, results, and conceptual advances in an exciting emerging field: endogenous non-neural bioelectric signaling, which enables cellular collectives to make global decisions and implement large-scale pattern homeostasis. Spatially distributed electric circuits regulate gene expression, organ morphogenesis, and body-wide axial patterning. Developmental bioelectricity facilitates the interface to organ-level modular control points that direct patterning in vivo. Cracking the bioelectric code will enable transformative progress in bioengineering and regenerative medicine. Copyright © 2018 Elsevier Ltd. All rights reserved.

  14. Leaf spray: direct chemical analysis of plant material and living plants by mass spectrometry.

    PubMed

    Liu, Jiangjiang; Wang, He; Cooks, R Graham; Ouyang, Zheng

    2011-10-15

    The chemical constituents of intact plant material, including living plants, are examined by a simple spray method that provides real-time information on sugars, amino acids, fatty acids, lipids, and alkaloids. The experiment is applicable to various plant parts and is demonstrated for a wide variety of species. An electrical potential is applied to the plant and its natural sap, or an applied solvent generates an electrospray that carries endogenous chemicals into an adjacent benchtop or miniature mass spectrometer. The sharp tip needed to create a high electric field can be either natural (e.g., bean sprout) or a small nick can be cut in a leaf, fruit, bark, etc. Stress-induced changes in glucosinolates can be followed on the minute time scale in several plants, including potted vegetables. Differences in spatial distributions and the possibility of studying plant metabolism are demonstrated. © 2011 American Chemical Society

  15. On spatial attention and its field size on the repulsion effect

    PubMed Central

    Cutrone, Elizabeth K.; Heeger, David J.; Carrasco, Marisa

    2018-01-01

    We investigated the attentional repulsion effect—stimuli appear displaced further away from attended locations—in three experiments: one with exogenous (involuntary) attention, and two with endogenous (voluntary) attention with different attention-field sizes. It has been proposed that differences in attention-field size can account for qualitative differences in neural responses elicited by attended stimuli. We used psychophysical comparative judgments and manipulated either exogenous attention via peripheral cues or endogenous attention via central cues and a demanding rapid serial visual presentation task. We manipulated the attention field size of endogenous attention by presenting streams of letters at two specific locations or at two of many possible locations during each block. We found a robust attentional repulsion effect in all three experiments: with endogenous and exogenous attention and with both attention-field sizes. These findings advance our understanding of the influence of spatial attention on the perception of visual space and help relate this repulsion effect to possible neurophysiological correlates.

  16. Electric field-induced suppression of PTEN drives epithelial-to-mesenchymal transition via mTORC1 activation.

    PubMed

    Yan, Tiantian; Jiang, Xupin; Guo, Xiaowei; Chen, Wen; Tang, Di; Zhang, Junhui; Zhang, Xingyue; Zhang, Dongxia; Zhang, Qiong; Jia, Jiezhi; Huang, Yuesheng

    2017-02-01

    Naturally occurring electric fields (EFs) are an intrinsic property of wounds. Endogenous EFs in skin wounds play critical roles in the dynamic and well-ordered biological process of wound healing. The epithelial-to-mesenchymal transition (EMT) allows keratinocytes to transition from sedentary cells to motile cells, facilitating wound healing. However, EMT-related studies have been performed without considering endogenous EFs. Thus, the relationship between electrical signals and the EMT remain elusive. Phosphatase and tension homolog (PTEN) and mammalian target of rapamycin complex 1 (mTORC1) are key molecules in sensing electrical cues, and they play significant roles in cellular responses to EFs. In addition, these molecules are closely related to the occurrence of the EMT in other cells. We used primary human keratinocytes to investigate the influence of EFs on the EMT as well as the roles of PTEN and mTORC1 in this process. The effects of EFs on the EMT were investigated by analyzing the levels of specific proteins and transcription factors. The roles of mTORC1 and PTEN and their relationship with each other were studied via pharmacological inhibition or genetic knockdown. A Zeiss imaging system and scratch assays were used to study single-cell motility and monolayer cell migration. EFs induced a range of both biochemical changes (e.g., increased Snail, Slug, vimentin, and N-cadherin expression, decreased E-cadherin expression) and functional changes (e.g., enhanced migratory capacity) that are characteristic of the EMT. EF-stimulated cells exhibited suppressed PTEN expression, and further PTEN downregulation led to the acquisition of more mesenchymal features and the loss of epithelial characteristics, which was accompanied by increased migratory capacity. PTEN overexpression reversed the EF-induced EMT and inhibited the migratory capacity of keratinocytes. EF-induced mTORC1 activation was a required component of the causal relationship between PTEN suppression and the EMT, as mTORC1 inhibition reversed the EMT induced by PTEN downregulation. Our data demonstrate that the EF-induced suppression of PTEN drives the EMT via mTORC1 activation, thereby revealing a new and promising role of EFs in facilitating wound reepithelialization. These results provide a novel perspective regarding the significance of EFs in wound healing; therefore, electrical stimulation offers a new avenue of wound management for improved and accelerated wound healing. Copyright © 2016 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.

  17. Influence of White and Gray Matter Connections on Endogenous Human Cortical Oscillations

    PubMed Central

    Hawasli, Ammar H.; Kim, DoHyun; Ledbetter, Noah M.; Dahiya, Sonika; Barbour, Dennis L.; Leuthardt, Eric C.

    2016-01-01

    Brain oscillations reflect changes in electrical potentials summated across neuronal populations. Low- and high-frequency rhythms have different modulation patterns. Slower rhythms are spatially broad, while faster rhythms are more local. From this observation, we hypothesized that low- and high-frequency oscillations reflect white- and gray-matter communications, respectively, and synchronization between low-frequency phase with high-frequency amplitude represents a mechanism enabling distributed brain-networks to coordinate local processing. Testing this common understanding, we selectively disrupted white or gray matter connections to human cortex while recording surface field potentials. Counter to our original hypotheses, we found that cortex consists of independent oscillatory-units (IOUs) that maintain their own complex endogenous rhythm structure. IOUs are differentially modulated by white and gray matter connections. White-matter connections maintain topographical anatomic heterogeneity (i.e., separable processing in cortical space) and gray-matter connections segregate cortical synchronization patterns (i.e., separable temporal processing through phase-power coupling). Modulation of distinct oscillatory modules enables the functional diversity necessary for complex processing in the human brain. PMID:27445767

  18. Long-Term Modulation of Electrical Synapses in the Mammalian Thalamus

    NASA Astrophysics Data System (ADS)

    Landisman, Carole E.; Connors, Barry W.

    2005-12-01

    Electrical synapses are common between inhibitory neurons in the mammalian thalamus and neocortex. Synaptic modulation, which allows flexibility of communication between neurons, has been studied extensively at chemical synapses, but modulation of electrical synapses in the mammalian brain has barely been examined. We found that the activation of metabotropic glutamate receptors, via endogenous neurotransmitter or by agonist, causes long-term reduction of electrical synapse strength between the inhibitory neurons of the rat thalamic reticular nucleus.

  19. Neurite Outgrowth On Electrospun PLLA Fibers Is Enhanced By Exogenous Electrical Stimulation

    PubMed Central

    Koppes, A. N.; Zaccor, N. W.; Rivet, C. J.; Williams, L. A.; Piselli, J. M.; Gilbert, R. J.; Thompson, D. M.

    2014-01-01

    Objective Both electrical stimuli (endogenous and exogenous) and topographical cues are instructive to axonal extension. This report, for the first time, investigated the relative dominance of directional topographical guidance cues and directional electrical cues to enhance and/or direct primary neurite extension. We hypothesized the combination of electrical stimulation with electrospun fiber topography would induce longer neurite extension from DRG neurons than the presence of electrical stimulation or aligned topography alone. Approach To test the hypothesis, neurite outgrowth was examined on laminin-coated poly-L-lactide (PLLA) films or electrospun fibers (2 μm in diameter) in the presence or absence of electrical stimulation. Immunostained neurons were semi-automatically traced using Neurolucida software and morphology was evaluated. Results Neurite extension increased 74% on the aligned fibers compared to film controls. Stimulation alone increased outgrowth by 32% on films or fibers relative to unstimulated film controls. The co-presentation of topographical (fibers) with biophysical (electrical stimulation) cues resulted in a synergistic 126% increase in outgrowth relative to unstimulated film controls. Field polarity had no influence on the directionality of neurite, indicating topographical cues are responsible to guide neurite extension. Significance Both cues (electrical stimulation and fiber geometry) are modular in nature and can be synergistically applied in conjunction with other common methods in regenerative medicine such as controlled release of growth factors to further influence axonal growth in vivo. The combined application of electrical and aligned fiber topographical guidance cues described herein, if translated in vivo, could provide a more supportive environment for directed and robust axonal regeneration following peripheral nerve injury. PMID:24891494

  20. Neurite outgrowth on electrospun PLLA fibers is enhanced by exogenous electrical stimulation.

    PubMed

    Koppes, A N; Zaccor, N W; Rivet, C J; Williams, L A; Piselli, J M; Gilbert, R J; Thompson, D M

    2014-08-01

    Both electrical stimuli (endogenous and exogenous) and topographical cues are instructive to axonal extension. This report, for the first time, investigated the relative dominance of directional topographical guidance cues and directional electrical cues to enhance and/or direct primary neurite extension. We hypothesized the combination of electrical stimulation with electrospun fiber topography would induce longer neurite extension from dorsal root ganglia neurons than the presence of electrical stimulation or aligned topography alone. To test the hypothesis, neurite outgrowth was examined on laminin-coated poly-L-lactide films or electrospun fibers (2 µm in diameter) in the presence or absence of electrical stimulation. Immunostained neurons were semi-automatically traced using Neurolucida software and morphology was evaluated. Neurite extension increased 74% on the aligned fibers compared to film controls. Stimulation alone increased outgrowth by 32% on films or fibers relative to unstimulated film controls. The co-presentation of topographical (fibers) with biophysical (electrical stimulation) cues resulted in a synergistic 126% increase in outgrowth relative to unstimulated film controls. Field polarity had no influence on the directionality of neurites, indicating topographical cues are responsible for guiding neurite extension. Both cues (electrical stimulation and fiber geometry) are modular in nature and can be synergistically applied in conjunction with other common methods in regenerative medicine such as controlled release of growth factors to further influence axonal growth in vivo. The combined application of electrical and aligned fiber topographical guidance cues described herein, if translated in vivo, could provide a more supportive environment for directed and robust axonal regeneration following peripheral nerve injury.

  1. Cell therapy for spinal cord injury informed by electromagnetic waves.

    PubMed

    Finnegan, Jack; Ye, Hui

    2016-10-01

    Spinal cord injury devastates the CNS, besetting patients with symptoms including but not limited to: paralysis, autonomic nervous dysfunction, pain disorders and depression. Despite the identification of several molecular and genetic factors, a reliable regenerative therapy has yet to be produced for this terminal disease. Perhaps the missing piece of this puzzle will be discovered within endogenous electrotactic cellular behaviors. Neurons and stem cells both show mediated responses (growth rate, migration, differentiation) to electromagnetic waves, including direct current electric fields. This review analyzes the pathophysiology of spinal cord injury, the rationale for regenerative cell therapy and the evidence for directing cell therapy via electromagnetic waves shown by in vitro experiments.

  2. Galvanic zinc-copper microparticles inhibit melanogenesis via multiple pigmentary pathways.

    PubMed

    Won, Yen-Kim; Lin, Connie B; Seiberg, Miri; Chen, Nannan; Hu, Yaping; Rossetti, Dianne; Saliou, Claude; Loy, Chong-Jin

    2014-01-01

    The endogenous electrical field of human skin plays an important role in many skin functions. However, the biological effects and mechanism of action of externally applied electrical stimulation on skin remain unclear. Recent study showed that galvanic zinc-copper microparticles produce electrical stimulation and reduce inflammatory and immune responses in intact skin, suggesting the important role of electrical stimulation in non-wounded skin. The objective of this study is to investigate the biological effect of galvanic zinc-copper microparticles on skin pigmentation. Our findings showed that galvanic zinc-copper microparticles inhibited melanogenesis in a human melanoma cell line (MNT-1), human keratinocytes and melanoma cells co-cultures, and in pigmented epidermal equivalents. Treatment of galvanic zinc-copper microparticles inhibited melanogenesis by reducing the promoter transactivation of tyrosinase and tyrosinase-related protein-1 in human melanoma cells. In a co-culture Transwell system of keratinocytes and melanoma cells, galvanic zinc-copper microparticles reduced melanin production via downregulation of endothelin-1 secretion from keratinocytes and reduced tyrosinase gene expression in melanoma cells. In addition, exposure of pigmented epidermal equivalents to galvanic zinc-copper microparticles resulted in reduced melanin deposition. In conclusion, our data demonstrated for the first time that galvanic zinc-copper microparticles reduced melanogenesis in melanoma cells and melanin deposition in pigmented epidermal equivalents by affecting multiple pigmentary pathways.

  3. Metabolomic profiling of prostate cancer by matrix assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry imaging using Matrix Coating Assisted by an Electric Field (MCAEF).

    PubMed

    Wang, Xiaodong; Han, Jun; Hardie, Darryl B; Yang, Juncong; Pan, Jingxi; Borchers, Christoph H

    2017-07-01

    In this work, we combined the use of two MALDI matrices (quercetin and 9-aminoacridine), a recently developed new matrix coating technique - matrix coating assisted by an electric field (MCAEF), and matrix-assisted laser desorption/ionization - Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICRMS) to detect and image endogenous compounds in the cancerous and non-cancerous regions of three human prostate cancer (stage II) tissue specimens. After three rounds of imaging data acquisitions (i.e., quercetin for positive and negative ion detection and 9-aminoacridine for negative ion detection), and metabolite identification, a total of 1091 metabolites including 1032 lipids and 59 other metabolites were routinely detected and successfully localized. Of these compounds, 250 and 217 were only detected in either the cancerous or the non-cancerous regions respectively, although we cannot rule out the presence of these metabolites at concentrations below the detection limit. In addition, 152 of the other 624 metabolites showed differential distributions (p<0.05, t-test) between the two regions of the tissues. Further studies on a larger number of clinical specimens will need to be carried out to confirm this large number of apparently cancer-related metabolites. The successful determination of the spatial locations and abundances of these endogenous biomolecules indicated significant metabolism abnormalities - e.g., increased energy charge and under-expression of neutral acyl glycerides, in the prostate cancer samples. To our knowledge, this work has resulted in MALDI-MS imaging of the largest group of metabolites in prostate cancer thus far and demonstrated the importance of using complementary matrices for comprehensive metabolomic imaging by MALDI-MS. This article is part of a Special Issue entitled: MALDI Imaging, edited by Dr. Corinna Henkel and Prof. Peter Hoffmann. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Analysis of the mechanisms by which amphetamine releases dopamine from striatal dopaminergic neurons

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Parker, E.M.

    1987-01-01

    The goals of the studies were (1) to determine the intraneuronal transmitter pools that contribute to the efflux of dopamine (DA) elicited by amphetamine (AMPH) and (2) to determine the biochemical mechanism by which AMPH increases DA efflux from dopaminergic neurons. AMPH increased the efflux of endogenous DA and decreased the electrically-evoked overflow of (/sup 3/H) acetylcholine (ACh) from superfused rabbit striatal slices. These effects were most pronounced when both vesicular DA stores and DA synthesis were intact. Therefore, extravesicular, newly synthesized DA and vesicular stores of DA contribute to AMPH-induced DA efflux. Simultaneous inhibition of monoamine oxidase (MAO) andmore » neuronal DA uptake did not increase the efflux of endogenous DA or inhibit the electrically-evoked overflow of (/sup 3/H)ACh to the same extent as AMPH. Hence, inhibition of MAO and neuronal DA uptake are probably not the major mechanisms by which AMPH increases DA efflux. The AMPH-induced efflux of endogenous or (/sup 3/H)DA was blocked by inhibitors of neuronal DA uptake.« less

  5. Effect of Transcutaneous Electrical Nerve Stimulation on Sensation Thresholds in Patients with Painful Diabetic Neuropathy: An Observational Study

    ERIC Educational Resources Information Center

    Moharic, Metka

    2010-01-01

    Transcutaneous electrical nerve stimulation (TENS) is one of the therapies for painful neuropathy. Its analgesic mechanisms probably involve the gate control theory, the physiological block and the endogenous pain inhibitory system. The aim of the study was to determine whether TENS improves small fibre function diminished because of painful…

  6. Modelling the role of intrinsic electric fields in microtubules as an additional control mechanism of bi-directional intracellular transport.

    PubMed

    Sataric, M V; Budinski-Petkovic, L; Loncarevic, I; Tuszynski, J A

    2008-01-01

    Active transport is essential for cellular function, while impaired transport has been linked to diseases such as neuronal degeneration. Much long distance transport in cells uses opposite polarity molecular motors of the kinesin and dynein families to move cargos along microtubules. It is clear that many types of cargo are moved by both sets of motors, and frequently in a reverse direction. The general question of how the direction of transport is regulated is still open. The mechanism of the cell's differential control of diverse cargos within the same cytoplasmic background is still unclear as is the answer to the question how endosomes and mitochondria move to different locations within the same cell. To answer these questions we postulate the existence of a local signaling mechanism used by the cell to specifically control different cargos. In particular, we propose an additional physical mechanism that works through the use of constant and alternating intrinsic (endogenous) electric fields as a means of controlling the speed and direction of microtubule-based transport. A specific model is proposed and analyzed in this paper. The model involves the rotational degrees of freedom of the C-termini of tubulin, their interactions and the coupling between elastic and dielectric degrees of freedom. Viscosity of the solution is also included and the resultant equation of motion is found as a nonlinear elliptic equation with dissipation. A particular analytical solution of this equation is obtained in the form of a kink whose properties are analyzed. It is concluded that this solution can be modulated by the presence of electric fields and hence may correspond to the observed behavior of motor protein transport along microtubules.

  7. Modulation of the release of ( sup 3 H)norepinephrine from the base and body of the rat urinary bladder by endogenous adrenergic and cholinergic mechanisms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Somogyi, G.T.; de Groat, W.C.

    Modulation of (3H)NE release was studied in rat urinary bladder strips prelabeled with (3H)NE. (3H)NE uptake occurred in strips from the bladder base and body, but was very prominent in the base where the noradrenergic innervation is most dense. Electrical field stimulation markedly increased (3H)NE outflow from the superfused tissue. The quantity of (3H)NE release was approximately equal during three consecutive periods of stimulation. Activation of presynaptic muscarinic receptors by 1.0 microM oxotremorine reduced (3H)NE release to 46% of the control. Atropine (1 microM) blocked the effect of oxotremorine and increased the release to 147% of predrug control levels. Activationmore » of presynaptic alpha-2 adrenoceptors by 1 microM clonidine reduced (3H)NE release to 55% of control. Yohimbine blocked the action of clonidine and increased the release to 148% of control. The release of (3H)NE from the bladder base and body was increased by both 1 microM atropine (to 167% and 174% of control, respectively) and 1 microM yohimbine (to 286% and 425% of control, respectively). Atropine and yohimbine administered in combination had similar facilitatory effects as when administered alone. We conclude that the release of (3H)NE from adrenergic nerve endings in electrically stimulated bladder strips is modulated via endogenous transmitters acting on both muscarinic and alpha-2 adrenergic presynaptic receptors and that the latter provide the most prominent control.« less

  8. Safety Implications of High-Field MRI: Actuation of Endogenous Magnetic Iron Oxides in the Human Body

    PubMed Central

    Dobson, Jon; Bowtell, Richard; Garcia-Prieto, Ana; Pankhurst, Quentin

    2009-01-01

    Background Magnetic Resonance Imaging scanners have become ubiquitous in hospitals and high-field systems (greater than 3 Tesla) are becoming increasingly common. In light of recent European Union moves to limit high-field exposure for those working with MRI scanners, we have evaluated the potential for detrimental cellular effects via nanomagnetic actuation of endogenous iron oxides in the body. Methodology Theoretical models and experimental data on the composition and magnetic properties of endogenous iron oxides in human tissue were used to analyze the forces on iron oxide particles. Principal Finding and Conclusions Results show that, even at 9.4 Tesla, forces on these particles are unlikely to disrupt normal cellular function via nanomagnetic actuation. PMID:19412550

  9. Tachykinin receptors and noncholinergic bronchoconstriction in the guinea-pig isolated bronchi.

    PubMed

    Maggi, C A; Patacchini, R; Rovero, P; Santicioli, P

    1991-08-01

    The aim of the study was to assess which type(s) of tachykinin receptor mediate the noncholinergic bronchoconstriction produced by activation (electrical field stimulation) of capsaicin-sensitive primary afferents in epithellum-denuded guinea-pig isolated bronchi. Experiments with natural and synthetic tachykinin agonists indicated the presence of both NK-1 and NK-2 receptors at this level. Experiments with the putative NK-1 (L668, 169) or NK-2 (MEN 10,207, MEN 10,376, L659,877, and R396) selective antagonists against NK-1 and NK-2 selective agonists further supported this conclusion. All the tachykinin antagonists tested reduced the noncholinergic bronchoconstriction to field stimulation with the order of potency MEN 10,207 = MEN 10,376 greater than L659,877 greater than L668,169 congruent to R396. In the presence of peptidase inhibitors, the activity of MEN 10,376 toward the noncholinergic bronchoconstriction was slightly reduced, whereas that of L668,169 was increased. These findings demonstrate that both NK-1 and NK-2 receptors mediate the noncholinergic constriction produced by endogenous tachykinins in guinea-pig bronchi and that the relative contribution of NK-2 receptors is greater than that of NK-1. These findings implicate a major role for neurokinin A rather than for substance P as an endogenous bronchoconstrictor in the guinea-pig isolated bronchi. In the presence of peptidase inhibitors, the relative contribution of NK-1 receptors is increased.

  10. Field-Based Approach for Assessing the Impact of Treated Pulp and Paper Mill Effluent on Endogenous Metabolites of Fathead Minnows (Pimephales promelas)

    EPA Science Inventory

    A field-based metabolomic study was conducted during a shutdown of a pulp and paper mill (PPM) to assess the impacts of treated PPM effluent on endogenous polar metabolites in fathead minnow (FHM; Pimephales promelas) livers. Caged male and female FHMs were deployed at a Great La...

  11. Lack of endogenous adenosine tonus on sympathetic neurotransmission in spontaneously hypertensive rat mesenteric artery.

    PubMed

    Sousa, Joana Beatriz; Vieira-Rocha, Maria Sofia; Sá, Carlos; Ferreirinha, Fátima; Correia-de-Sá, Paulo; Fresco, Paula; Diniz, Carmen

    2014-01-01

    Increased sympathetic activity has been implicated in hypertension. Adenosine has been shown to play a role in blood flow regulation. In the present study, the endogenous adenosine neuromodulatory role, in mesenteric arteries from normotensive and spontaneously hypertensive rats, was investigated. The role of endogenous adenosine in sympathetic neurotransmission was studied using electrically-evoked [3H]-noradrenaline release experiments. Purine content was determined by HPLC with fluorescence detection. Localization of adenosine A1 or A2A receptors in adventitia of mesenteric arteries was investigated by Laser Scanning Confocal Microscopy. Results indicate a higher electrically-evoked noradrenaline release from hypertensive mesenteric arteries. The tonic inhibitory modulation of noradrenaline release is mediated by adenosine A1 receptors and is lacking in arteries from hypertensive animals, despite their purine levels being higher comparatively to those determined in normotensive ones. Tonic facilitatory adenosine A2A receptor-mediated effects were absent in arteries from both strains. Immunohistochemistry revealed an adenosine A1 receptors redistribution from sympathetic fibers to Schwann cells, in adventitia of hypertensive mesenteric arteries which can explain, at least in part, the absence of effects observed for these receptors. Data highlight the role of purines in hypertension revealing that an increase in sympathetic activity in hypertensive arteries is occurring due to a higher noradrenaline/ATP release from sympathetic nerves and the loss of endogenous adenosine inhibitory tonus. The observed nerve-to-glial redistribution of inhibitory adenosine A1 receptors in hypertensive arteries may explain the latter effect.

  12. Transcranial fluorescence imaging of auditory cortical plasticity regulated by acoustic environments in mice.

    PubMed

    Takahashi, Kuniyuki; Hishida, Ryuichi; Kubota, Yamato; Kudoh, Masaharu; Takahashi, Sugata; Shibuki, Katsuei

    2006-03-01

    Functional brain imaging using endogenous fluorescence of mitochondrial flavoprotein is useful for investigating mouse cortical activities via the intact skull, which is thin and sufficiently transparent in mice. We applied this method to investigate auditory cortical plasticity regulated by acoustic environments. Normal mice of the C57BL/6 strain, reared in various acoustic environments for at least 4 weeks after birth, were anaesthetized with urethane (1.7 g/kg, i.p.). Auditory cortical images of endogenous green fluorescence in blue light were recorded by a cooled CCD camera via the intact skull. Cortical responses elicited by tonal stimuli (5, 10 and 20 kHz) exhibited mirror-symmetrical tonotopic maps in the primary auditory cortex (AI) and anterior auditory field (AAF). Depression of auditory cortical responses regarding response duration was observed in sound-deprived mice compared with naïve mice reared in a normal acoustic environment. When mice were exposed to an environmental tonal stimulus at 10 kHz for more than 4 weeks after birth, the cortical responses were potentiated in a frequency-specific manner in respect to peak amplitude of the responses in AI, but not for the size of the responsive areas. Changes in AAF were less clear than those in AI. To determine the modified synapses by acoustic environments, neural responses in cortical slices were investigated with endogenous fluorescence imaging. The vertical thickness of responsive areas after supragranular electrical stimulation was significantly reduced in the slices obtained from sound-deprived mice. These results suggest that acoustic environments regulate the development of vertical intracortical circuits in the mouse auditory cortex.

  13. Endomorphin-2 is Released from Newborn Rat Primary Sensory Neurons in a Frequency- and Calcium- Dependent Manner

    PubMed Central

    Scanlin, Heather L.; Carroll, Elizabeth A.; Jenkins, Victoria K.; Balkowiec, Agnieszka

    2008-01-01

    Recent evidence indicates that endomorphins, endogenous mu-opioid receptor (MOR) agonists, modulate synaptic transmission in both somatic and visceral sensory pathways. Here we show that endomorphin-2 (END-2) is expressed in newborn rat dorsal root ganglion (DRG) and nodose-petrosal ganglion complex (NPG) neurons, and rarely co-localizes with brain-derived neurotrophic factor (BDNF). In order to examine activity-dependent release of END-2 from neurons, we established a model using dispersed cultures of DRG and NPG cells activated by patterned electrical field stimulation. To detect release of END-2, we developed a novel rapid capture ELISA, in which END-2 capture antibody was added to neuronal cultures shortly before their electrical stimulation. The conventional assay was effective at reliably detecting END-2 only when the cells were stimulated in the presence of CTAP, a MOR-selective antagonist. This suggests that the strength of the novel assay is related primarily to rapid capture of released END-2 before it binds to endogenous MORs. Using the rapid capture ELISA, we found that stimulation protocols known to induce plastic changes at sensory synapses were highly effective at releasing END-2. Removal of extracellular calcium or blocking voltage-activated calcium channels significantly reduced the release. Together, our data provide the first evidence that END-2 is expressed by newborn DRG neurons of all sizes found in this age group, and can be released from these, as well as from NPG neurons, in an activity-dependent manner. These results point to END-2 as a likely mediator of activity-dependent plasticity in sensory pathways. PMID:18513316

  14. Expression of endogenous proteins in maize hybrids in a multi-location field trial in India.

    PubMed

    Gutha, Linga R; Purushottam, Divakar; Veeramachaneni, Aruna; Tigulla, Sarita; Kodappully, Vikas; Enjala, Chandana; Rajput, Hitendrasinh; Anderson, Jennifer; Hong, Bonnie; Schmidt, Jean; Bagga, Shveta

    2018-05-17

    Genetically modified (GM) crops undergo large scale multi-location field trials to characterize agronomics, composition, and the concentration of newly expressed protein(s) [herein referred to as transgenic protein(s)]. The concentration of transgenic proteins in different plant tissues and across the developmental stages of the plant is considered in the safety assessment of GM crops. Reference or housekeeping proteins are expected to maintain a relatively stable expression pattern in healthy plants given their role in cellular functions. Understanding the effects of genotype, growth stage and location on the concentration of endogenous housekeeping proteins may provide insight into the contribution these factors could have on transgenic protein concentrations in GM crops. The concentrations of three endogenous proteins (actin, elongation factor 1-alpha, and glyceraldehyde 3-phosphate dehydrogenase) were measured in several different maize hybrids grown across multiple field locations over 2 years. Leaf samples were collected from healthy plants at three developmental stages across the growing seasons, and protein concentrations were quantified by indirect enzyme-linked immunosorbent assay (ELISA) for each protein. In general, the concentrations of these three endogenous proteins were relatively consistent across hybrid backgrounds, when compared within one growth stage and location (2-26%CV), whereas the concentrations of proteins in the same hybrid and growth stage across different locations were more variable (12-64%CV). In general, the protein concentrations in 2013 and 2014 show similar trends in variability. Some degree of variability in protein concentrations should be expected for both transgenic and endogenous plant-expressed proteins. In the case of GM crops, the potential variation in protein concentrations due to location effects is captured in the current model of multi-location field testing.

  15. Endogenous opiates and behavior: 2007.

    PubMed

    Bodnar, Richard J

    2008-12-01

    This paper is the thirtieth consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2007 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior, and the roles of these opioid peptides and receptors in pain and analgesia; stress and social status; tolerance and dependence; learning and memory; eating and drinking; alcohol and drugs of abuse; sexual activity and hormones, pregnancy, development and endocrinology; mental illness and mood; seizures and neurologic disorders; electrical-related activity and neurophysiology; general activity and locomotion; gastrointestinal, renal and hepatic functions; cardiovascular responses; respiration and thermoregulation; and immunological responses.

  16. Tryptophan availability modulates serotonin release from rat hypothalamic slices

    NASA Technical Reports Server (NTRS)

    Schaechter, Judith D.; Wurtman, Richard J.

    1989-01-01

    The relationship between the tryptophan availability and serononin release from rat hypothalamus was investigated using a new in vitro technique for estimating rates at which endogenous serotonin is released spontaneously or upon electrical depolarization from hypothalamic slices superfused with a solution containing various amounts of tryptophan. It was found that the spontaneous, as well as electrically induced, release of serotonin from the brain slices exhibited a dose-dependent relationship with the tryptophan concentration of the superfusion medium.

  17. Electric propulsion technology

    NASA Technical Reports Server (NTRS)

    Finke, R. C.

    1980-01-01

    The advanced electric propulsion program is directed towards lowering the specific impulse and increasing the thrust per unit of ion thruster systems. In addition, electrothermal and electromagnetic propulsion technologies are being developed to attempt to fill the gap between the conventional ion thruster and chemical rocket systems. Most of these new concepts are exagenous and are represented by rail accelerators, ablative Teflon thrusters, MPD arcs, Free Radicals, etc. Endogenous systems such as metallic hydrogen offer great promise and are also being pursued.

  18. Hippocampal Sharp-Wave Ripples Influence Selective Activation of the Default Mode Network

    PubMed Central

    Kaplan, Raphael; Adhikari, Mohit H.; Hindriks, Rikkert; Mantini, Dante; Murayama, Yusuke; Logothetis, Nikos K.; Deco, Gustavo

    2016-01-01

    Summary The default mode network (DMN) is a commonly observed resting-state network (RSN) that includes medial temporal, parietal, and prefrontal regions involved in episodic memory [1, 2, 3]. The behavioral relevance of endogenous DMN activity remains elusive, despite an emerging literature correlating resting fMRI fluctuations with memory performance [4, 5]—particularly in DMN regions [6, 7, 8]. Mechanistic support for the DMN’s role in memory consolidation might come from investigation of large deflections (sharp-waves) in the hippocampal local field potential that co-occur with high-frequency (>80 Hz) oscillations called ripples—both during sleep [9, 10] and awake deliberative periods [11, 12, 13]. Ripples are ideally suited for memory consolidation [14, 15], since the reactivation of hippocampal place cell ensembles occurs during ripples [16, 17, 18, 19]. Moreover, the number of ripples after learning predicts subsequent memory performance in rodents [20, 21, 22] and humans [23], whereas electrical stimulation of the hippocampus after learning interferes with memory consolidation [24, 25, 26]. A recent study in macaques showed diffuse fMRI neocortical activation and subcortical deactivation specifically after ripples [27]. Yet it is unclear whether ripples and other hippocampal neural events influence endogenous fluctuations in specific RSNs—like the DMN—unitarily. Here, we examine fMRI datasets from anesthetized monkeys with simultaneous hippocampal electrophysiology recordings, where we observe a dramatic increase in the DMN fMRI signal following ripples, but not following other hippocampal electrophysiological events. Crucially, we find increases in ongoing DMN activity after ripples, but not in other RSNs. Our results relate endogenous DMN fluctuations to hippocampal ripples, thereby linking network-level resting fMRI fluctuations with behaviorally relevant circuit-level neural dynamics. PMID:26898464

  19. Multi-session transcranial direct current stimulation (tDCS) elicits inflammatory and regenerative processes in the rat brain.

    PubMed

    Rueger, Maria Adele; Keuters, Meike Hedwig; Walberer, Maureen; Braun, Ramona; Klein, Rebecca; Sparing, Roland; Fink, Gereon Rudolf; Graf, Rudolf; Schroeter, Michael

    2012-01-01

    Transcranial direct current stimulation (tDCS) is increasingly being used in human studies as an adjuvant tool to promote recovery of function after stroke. However, its neurobiological effects are still largely unknown. Electric fields are known to influence the migration of various cell types in vitro, but effects in vivo remain to be shown. Hypothesizing that tDCS might elicit the recruitment of cells to the cortex, we here studied the effects of tDCS in the rat brain in vivo. Adult Wistar rats (n = 16) were randomized to either anodal or cathodal stimulation for either 5 or 10 consecutive days (500 µA, 15 min). Bromodeoxyuridine (BrdU) was given systemically to label dividing cells throughout the experiment. Immunohistochemical analyses ex vivo included stainings for activated microglia and endogenous neural stem cells (NSC). Multi-session tDCS with the chosen parameters did not cause a cortical lesion. An innate immune response with early upregulation of Iba1-positive activated microglia occurred after both cathodal and anodal tDCS. The involvement of adaptive immunity as assessed by ICAM1-immunoreactivity was less pronounced. Most interestingly, only cathodal tDCS increased the number of endogenous NSC in the stimulated cortex. After 10 days of cathodal stimulation, proliferating NSC increased by ∼60%, with a significant effect of both polarity and number of tDCS sessions on the recruitment of NSC. We demonstrate a pro-inflammatory effect of both cathodal and anodal tDCS, and a polarity-specific migratory effect on endogenous NSC in vivo. Our data suggest that tDCS in human stroke patients might also elicit NSC activation and modulate neuroinflammation.

  20. An Environmental and Economic Evaluation of Pyrolysis for Energy Generation in Taiwan with Endogenous Land Greenhouse Gases Emissions

    PubMed Central

    Kung, Chih-Chun; McCarl, Bruce A.; Chen, Chi-Chung

    2014-01-01

    Taiwan suffers from energy insecurity and the threat of potential damage from global climate changes. Finding ways to alleviate these forces is the key to Taiwan’s future social and economic development. This study examines the economic and environmental impacts when ethanol, conventional electricity and pyrolysis-based electricity are available alternatives. Biochar, as one of the most important by-product from pyrolysis, has the potential to provide significant environmental benefits. Therefore, alternative uses of biochar are also examined in this study. In addition, because planting energy crops would change the current land use pattern, resulting in significant land greenhouse gases (GHG) emissions, this important factor is also incorporated. Results show that bioenergy production can satisfy part of Taiwan’s energy demand, but net GHG emissions offset declines if ethanol is chosen. Moreover, at high GHG price conventional electricity and ethanol will be driven out and pyrolysis will be a dominant technology. Fast pyrolysis dominates when ethanol and GHG prices are low, but slow pyrolysis is dominant at high GHG price, especially when land GHG emissions are endogenously incorporated. The results indicate that when land GHG emission is incorporated, up to 3.8 billion kWh electricity can be produced from fast pyrolysis, while up to 2.2 million tons of CO2 equivalent can be offset if slow pyrolysis is applied. PMID:24619159

  1. An environmental and economic evaluation of pyrolysis for energy generation in Taiwan with endogenous land greenhouse gases emissions.

    PubMed

    Kung, Chih-Chun; McCarl, Bruce A; Chen, Chi-Chung

    2014-03-11

    Taiwan suffers from energy insecurity and the threat of potential damage from global climate changes. Finding ways to alleviate these forces is the key to Taiwan's future social and economic development. This study examines the economic and environmental impacts when ethanol, conventional electricity and pyrolysis-based electricity are available alternatives. Biochar, as one of the most important by-product from pyrolysis, has the potential to provide significant environmental benefits. Therefore, alternative uses of biochar are also examined in this study. In addition, because planting energy crops would change the current land use pattern, resulting in significant land greenhouse gases (GHG) emissions, this important factor is also incorporated. Results show that bioenergy production can satisfy part of Taiwan's energy demand, but net GHG emissions offset declines if ethanol is chosen. Moreover, at high GHG price conventional electricity and ethanol will be driven out and pyrolysis will be a dominant technology. Fast pyrolysis dominates when ethanol and GHG prices are low, but slow pyrolysis is dominant at high GHG price, especially when land GHG emissions are endogenously incorporated. The results indicate that when land GHG emission is incorporated, up to 3.8 billion kWh electricity can be produced from fast pyrolysis, while up to 2.2 million tons of CO2 equivalent can be offset if slow pyrolysis is applied.

  2. ElectroTaxis-on-a-Chip (ETC): an integrated quantitative high-throughput screening platform for electrical field-directed cell migration.

    PubMed

    Zhao, Siwei; Zhu, Kan; Zhang, Yan; Zhu, Zijie; Xu, Zhengping; Zhao, Min; Pan, Tingrui

    2014-11-21

    Both endogenous and externally applied electrical stimulation can affect a wide range of cellular functions, including growth, migration, differentiation and division. Among those effects, the electrical field (EF)-directed cell migration, also known as electrotaxis, has received broad attention because it holds great potential in facilitating clinical wound healing. Electrotaxis experiment is conventionally conducted in centimetre-sized flow chambers built in Petri dishes. Despite the recent efforts to adapt microfluidics for electrotaxis studies, the current electrotaxis experimental setup is still cumbersome due to the needs of an external power supply and EF controlling/monitoring systems. There is also a lack of parallel experimental systems for high-throughput electrotaxis studies. In this paper, we present a first independently operable microfluidic platform for high-throughput electrotaxis studies, integrating all functional components for cell migration under EF stimulation (except microscopy) on a compact footprint (the same as a credit card), referred to as ElectroTaxis-on-a-Chip (ETC). Inspired by the R-2R resistor ladder topology in digital signal processing, we develop a systematic approach to design an infinitely expandable microfluidic generator of EF gradients for high-throughput and quantitative studies of EF-directed cell migration. Furthermore, a vacuum-assisted assembly method is utilized to allow direct and reversible attachment of our device to existing cell culture media on biological surfaces, which separates the cell culture and device preparation/fabrication steps. We have demonstrated that our ETC platform is capable of screening human cornea epithelial cell migration under the stimulation of an EF gradient spanning over three orders of magnitude. The screening results lead to the identification of the EF-sensitive range of that cell type, which can provide valuable guidance to the clinical application of EF-facilitated wound healing.

  3. Ephemeral Electric Potential and Electric Field Sensor

    NASA Technical Reports Server (NTRS)

    Generazio, Edward R. (Inventor)

    2017-01-01

    Systems, methods, and devices of the various embodiments provide for the minimization of the effects of intrinsic and extrinsic leakage electrical currents enabling true measurements of electric potentials and electric fields. In an embodiment, an ephemeral electric potential and electric field sensor system may have at least one electric field sensor and a rotator coupled to the electric field sensor and be configured to rotate the electric field sensor at a quasi-static frequency. In an embodiment, ephemeral electric potential and electric field measurements may be taken by rotating at least one electric field sensor at a quasi-static frequency, receiving electrical potential measurements from the electric field sensor when the electric field sensor is rotating at the quasi-static frequency, and generating and outputting images based at least in part on the received electrical potential measurements.

  4. Endogenous angiotensin affects responses to stimulation of baroreceptor afferent nerves.

    PubMed

    DiBona, Gerald F; Jones, Susan Y

    2003-08-01

    To study effects of endogenous angiotensin II on responses to standardized stimulation of afferent neural input into the central portion of the arterial and cardiac baroreflexes. Different dietary sodium intakes were used to physiologically alter endogenous angiotensin II activity. Candesartan, an angiotensin II type 1 receptor antagonist, was used to assess dependency of observed effects on angiotensin II stimulation of angiotensin II type 1 receptors. Electrical stimulation of arterial and cardiac baroreflex afferent nerves was used to provide a standardized input to the central portion of the arterial and cardiac baroreflexes. In anesthetized rats in balance on low, normal and high dietary sodium intake, arterial pressure, heart rate and renal sympathetic nerve activity responses to electrical stimulation of vagus and aortic depressor nerves were determined. Compared with plasma renin activity values in normal dietary sodium intake rats, those from low dietary sodium intake rats were higher and those from high dietary sodium intake rats were lower. During vagus nerve stimulation, the heart rate, arterial pressure and renal sympathetic nerve activity responses were similar in all three dietary sodium intake groups. During aortic depressor nerve stimulation, the heart rate and arterial pressure responses were similar in all three dietary sodium intake groups. However, the renal sympathetic nerve activity response was significantly greater in the low sodium group than in the normal and high sodium group at 4, 8 and 16 Hz. Candesartan administered to low dietary sodium intake rats had no effect on the heart rate and arterial pressure responses to either vagus or aortic depressor nerve stimulation but increased the magnitude of the renal sympathoinhibitory responses. Increased endogenous angiotensin II in rats on a low dietary sodium intake attenuates the renal sympathoinhibitory response to activation of the cardiac and sinoaortic baroreflexes by standardized vagus and aortic depressor nerve stimulation, respectively.

  5. Bioelectronic neural pixel: Chemical stimulation and electrical sensing at the same site

    PubMed Central

    Jonsson, Amanda; Inal, Sahika; Uguz, Ilke; Williamson, Adam J.; Kergoat, Loïg; Rivnay, Jonathan; Khodagholy, Dion; Berggren, Magnus; Bernard, Christophe; Malliaras, George G.

    2016-01-01

    Local control of neuronal activity is central to many therapeutic strategies aiming to treat neurological disorders. Arguably, the best solution would make use of endogenous highly localized and specialized regulatory mechanisms of neuronal activity, and an ideal therapeutic technology should sense activity and deliver endogenous molecules at the same site for the most efficient feedback regulation. Here, we address this challenge with an organic electronic multifunctional device that is capable of chemical stimulation and electrical sensing at the same site, at the single-cell scale. Conducting polymer electrodes recorded epileptiform discharges induced in mouse hippocampal preparation. The inhibitory neurotransmitter, γ-aminobutyric acid (GABA), was then actively delivered through the recording electrodes via organic electronic ion pump technology. GABA delivery stopped epileptiform activity, recorded simultaneously and colocally. This multifunctional “neural pixel” creates a range of opportunities, including implantable therapeutic devices with automated feedback, where locally recorded signals regulate local release of specific therapeutic agents. PMID:27506784

  6. Endogenous Opiates and Behavior: 2015.

    PubMed

    Bodnar, Richard J

    2017-02-01

    This paper is the thirty-eighth consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2015 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior, and the roles of these opioid peptides and receptors in pain and analgesia, stress and social status, tolerance and dependence, learning and memory, eating and drinking, drug abuse and alcohol, sexual activity and hormones, pregnancy, development and endocrinology, mental illness and mood, seizures and neurologic disorders, electrical-related activity and neurophysiology, general activity and locomotion, gastrointestinal, renal and hepatic functions, cardiovascular responses, respiration and thermoregulation, and immunological responses. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Endogenous opiates and behavior: 2013.

    PubMed

    Bodnar, Richard J

    2014-12-01

    This paper is the thirty-sixth consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2013 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior, and the roles of these opioid peptides and receptors in pain and analgesia; stress and social status; tolerance and dependence; learning and memory; eating and drinking; alcohol and drugs of abuse; sexual activity and hormones, pregnancy, development and endocrinology; mental illness and mood; seizures and neurologic disorders; electrical-related activity and neurophysiology; general activity and locomotion; gastrointestinal, renal and hepatic functions; cardiovascular responses; respiration and thermoregulation; and immunological responses. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. Endogenous opiates and behavior: 2004.

    PubMed

    Bodnar, Richard J; Klein, Gad E

    2005-12-01

    This paper is the 27th consecutive installment of the annual review of research concerning the endogenous opioid system, now spanning over 30 years of research. It summarizes papers published during 2004 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior, and the roles of these opioid peptides and receptors in pain and analgesia; stress and social status; tolerance and dependence; learning and memory; eating and drinking; alcohol and drugs of abuse; sexual activity and hormones, pregnancy, development and endocrinology; mental illness and mood; seizures and neurologic disorders; electrical-related activity and neurophysiology; general activity and locomotion; gastrointestinal, renal and hepatic functions; cardiovascular responses; respiration and thermoregulation; and immunological responses.

  9. Tripolar electric field Structure in guide field magnetic reconnection

    NASA Astrophysics Data System (ADS)

    Fu, Song; Huang, Shiyong; Zhou, Meng; Ni, Binbin; Deng, Xiaohua

    2018-03-01

    It has been shown that the guide field substantially modifies the structure of the reconnection layer. For instance, the Hall magnetic and electric fields are distorted in guide field reconnection compared to reconnection without guide fields (i.e., anti-parallel reconnection). In this paper, we performed 2.5-D electromagnetic full particle simulation to study the electric field structures in magnetic reconnection under different initial guide fields (Bg). Once the amplitude of a guide field exceeds 0.3 times the asymptotic magnetic field B0, the traditional bipolar Hall electric field is clearly replaced by a tripolar electric field, which consists of a newly emerged electric field and the bipolar Hall electric field. The newly emerged electric field is a convective electric field about one ion inertial length away from the neutral sheet. It arises from the disappearance of the Hall electric field due to the substantial modification of the magnetic field and electric current by the imposed guide field. The peak magnitude of this new electric field increases linearly with the increment of guide field strength. Possible applications of these results to space observations are also discussed.

  10. Endogenous opiates and behavior: 2014.

    PubMed

    Bodnar, Richard J

    2016-01-01

    This paper is the thirty-seventh consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2014 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior (endogenous opioids and receptors), and the roles of these opioid peptides and receptors in pain and analgesia (pain and analgesia); stress and social status (human studies); tolerance and dependence (opioid mediation of other analgesic responses); learning and memory (stress and social status); eating and drinking (stress-induced analgesia); alcohol and drugs of abuse (emotional responses in opioid-mediated behaviors); sexual activity and hormones, pregnancy, development and endocrinology (opioid involvement in stress response regulation); mental illness and mood (tolerance and dependence); seizures and neurologic disorders (learning and memory); electrical-related activity and neurophysiology (opiates and conditioned place preferences (CPP)); general activity and locomotion (eating and drinking); gastrointestinal, renal and hepatic functions (alcohol and drugs of abuse); cardiovascular responses (opiates and ethanol); respiration and thermoregulation (opiates and THC); and immunological responses (opiates and stimulants). This paper is the thirty-seventh consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2014 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior (endogenous opioids and receptors), and the roles of these opioid peptides and receptors in pain and analgesia (pain and analgesia); stress and social status (human studies); tolerance and dependence (opioid mediation of other analgesic responses); learning and memory (stress and social status); eating and drinking (stress-induced analgesia); alcohol and drugs of abuse (emotional responses in opioid-mediated behaviors); sexual activity and hormones, pregnancy, development and endocrinology (opioid involvement in stress response regulation); mental illness and mood (tolerance and dependence); seizures and neurologic disorders (learning and memory); electrical-related activity and neurophysiology (opiates and conditioned place preferences (CPP)); general activity and locomotion (eating and drinking); gastrointestinal, renal and hepatic functions (alcohol and drugs of abuse); cardiovascular responses (opiates and ethanol); respiration and thermoregulation (opiates and THC); and immunological responses (opiates and stimulants). Copyright © 2015 Elsevier Inc. All rights reserved.

  11. P2X and P2Y Receptors Mediate Contraction Induced by Electrical Field Stimulation in Feline Esophageal Smooth Muscle.

    PubMed

    Cho, Young Rae; Jang, Hyeon Soon; Kim, Won; Park, Sun Young; Sohn, Uy Dong

    2010-10-01

    It is well-known that electrical field stimulation (EFS)-induced contraction is mediated by a cholinergic mechanism and other neurotransmitters. NO, ATP, calcitonin gene-related peptide (CGRP), and substance P are released by EFS. To investigate the purinergic mechanism involved in the EFS-induced contraction, purinegic receptors antagonists were used. Suramine, a non-selective P2 receptor antagonist, reduced the contraction induced by EFS. NF023 (10(-7)~10(-4) M), a selective P2X antagonist, inhibited the contraction evoked by EFS. Reactive blue (10(-6)~10(-4) M), selective P2Y antagonist, also blocked the contraction in a dose-dependent manner. In addition, P2X agonist α,β-methylene 5'-adenosine triphosphate (αβMeATP, 10(-7)~10(-5) M) potentiated EFS-induced contraction in a dose-dependent manner. P2Y agonist adenosine 5'-[β-thio]diphosphate trilithium salt (ADPβS, 10(-7)~10(-5) M) also potentiated EFS-induced contractions in a dose-dependent manner. Ecto-ATPase activator apyrase (5 and 10 U/ml) reduced EFS-induced contractions. Inversely, 6-N,N-diethyl-D-β,γ-dibromomethylene 5'-triphosphate triammonium (ARL 67156, 10(-4) M) increased EFS-induced contraction. These data suggest that endogenous ATP plays a role in EFS-induced contractions which are mediated through both P2X-receptors and P2Y-receptors stimulation in cat esophageal smooth muscle.

  12. Wireless Electrical Device Using Open-Circuit Elements Having No Electrical Connections

    NASA Technical Reports Server (NTRS)

    Taylor, Bryant Douglas (Inventor); Woodard, Stanley E. (Inventor)

    2012-01-01

    A wireless electrical device includes an electrically unconnected electrical conductor and at least one electrically unconnected electrode spaced apart from the electrical conductor. The electrical conductor is shaped for storage of an electric field and a magnetic field. In the presence of a time-varying magnetic field, the electrical conductor so-shaped resonates to generate harmonic electric and magnetic field responses. Each electrode is at a location lying within the magnetic field response so-generated and is constructed such that a linear movement of electric charges is generated in each electrode due to the magnetic field response so-generated.

  13. Static electric fields modify the locomotory behaviour of cockroaches.

    PubMed

    Jackson, Christopher W; Hunt, Edmund; Sharkh, Suleiman; Newland, Philip L

    2011-06-15

    Static electric fields are found throughout the environment and there is growing interest in how electric fields influence insect behaviour. Here we have analysed the locomotory behaviour of cockroaches (Periplaneta americana) in response to static electric fields at levels equal to and above those found in the natural environment. Walking behaviour (including velocity, distance moved, turn angle and time spent walking) were analysed as cockroaches approached an electric field boundary in an open arena, and also when continuously exposed to an electric field. On approaching an electric field boundary, the greater the electric field strength the more likely a cockroach would be to turn away from, or be repulsed by, the electric field. Cockroaches completely exposed to electric fields showed significant changes in locomotion by covering less distance, walking slowly and turning more often. This study highlights the importance of electric fields on the normal locomotory behaviour of insects.

  14. The Effects of Spatial Endogenous Pre-cueing across Eccentricities

    PubMed Central

    Feng, Jing; Spence, Ian

    2017-01-01

    Frequently, we use expectations about likely locations of a target to guide the allocation of our attention. Despite the importance of this attentional process in everyday tasks, examination of pre-cueing effects on attention, particularly endogenous pre-cueing effects, has been relatively little explored outside an eccentricity of 20°. Given the visual field has functional subdivisions that attentional processes can differ significantly among the foveal, perifoveal, and more peripheral areas, how endogenous pre-cues that carry spatial information of targets influence our allocation of attention across a large visual field (especially in the more peripheral areas) remains unclear. We present two experiments examining how the expectation of the location of the target shapes the distribution of attention across eccentricities in the visual field. We measured participants’ ability to pick out a target among distractors in the visual field after the presentation of a highly valid cue indicating the size of the area in which the target was likely to occur, or the likely direction of the target (left or right side of the display). Our first experiment showed that participants had a higher target detection rate with faster responses, particularly at eccentricities of 20° and 30°. There was also a marginal advantage of pre-cueing effects when trials of the same size cue were blocked compared to when trials were mixed. Experiment 2 demonstrated a higher target detection rate when the target occurred at the cued direction. This pre-cueing effect was greater at larger eccentricities and with a longer cue-target interval. Our findings on the endogenous pre-cueing effects across a large visual area were summarized using a simple model to assist in conceptualizing the modifications of the distribution of attention over the visual field. We discuss our finding in light of cognitive penetration of perception, and highlight the importance of examining attentional process across a large area of the visual field. PMID:28638353

  15. The Effects of Spatial Endogenous Pre-cueing across Eccentricities.

    PubMed

    Feng, Jing; Spence, Ian

    2017-01-01

    Frequently, we use expectations about likely locations of a target to guide the allocation of our attention. Despite the importance of this attentional process in everyday tasks, examination of pre-cueing effects on attention, particularly endogenous pre-cueing effects, has been relatively little explored outside an eccentricity of 20°. Given the visual field has functional subdivisions that attentional processes can differ significantly among the foveal, perifoveal, and more peripheral areas, how endogenous pre-cues that carry spatial information of targets influence our allocation of attention across a large visual field (especially in the more peripheral areas) remains unclear. We present two experiments examining how the expectation of the location of the target shapes the distribution of attention across eccentricities in the visual field. We measured participants' ability to pick out a target among distractors in the visual field after the presentation of a highly valid cue indicating the size of the area in which the target was likely to occur, or the likely direction of the target (left or right side of the display). Our first experiment showed that participants had a higher target detection rate with faster responses, particularly at eccentricities of 20° and 30°. There was also a marginal advantage of pre-cueing effects when trials of the same size cue were blocked compared to when trials were mixed. Experiment 2 demonstrated a higher target detection rate when the target occurred at the cued direction. This pre-cueing effect was greater at larger eccentricities and with a longer cue-target interval. Our findings on the endogenous pre-cueing effects across a large visual area were summarized using a simple model to assist in conceptualizing the modifications of the distribution of attention over the visual field. We discuss our finding in light of cognitive penetration of perception, and highlight the importance of examining attentional process across a large area of the visual field.

  16. Electric Field Sensor for Lightning Early Warning System

    NASA Astrophysics Data System (ADS)

    Premlet, B.; Mohammed, R.; Sabu, S.; Joby, N. E.

    2017-12-01

    Electric field mills are used popularly for atmospheric electric field measurements. Atmospheric Electric Field variation is the primary signature for Lightning Early Warning systems. There is a characteristic change in the atmospheric electric field before lightning during a thundercloud formation.A voltage controlled variable capacitance is being proposed as a method for non-contacting measurement of electric fields. A varactor based mini electric field measurement system is developed, to detect any change in the atmospheric electric field and to issue lightning early warning system. Since this is a low-cost device, this can be used for developing countries which are facing adversities. A network of these devices can help in forming a spatial map of electric field variations over a region, and this can be used for more improved atmospheric electricity studies in developing countries.

  17. Apparatuses and methods for generating electric fields

    DOEpatents

    Scott, Jill R; McJunkin, Timothy R; Tremblay, Paul L

    2013-08-06

    Apparatuses and methods relating to generating an electric field are disclosed. An electric field generator may include a semiconductive material configured in a physical shape substantially different from a shape of an electric field to be generated thereby. The electric field is generated when a voltage drop exists across the semiconductive material. A method for generating an electric field may include applying a voltage to a shaped semiconductive material to generate a complex, substantially nonlinear electric field. The shape of the complex, substantially nonlinear electric field may be configured for directing charged particles to a desired location. Other apparatuses and methods are disclosed.

  18. Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice

    PubMed Central

    Jessberger, Jakob; Zhong, Weiwei; Brankačk, Jurij; Draguhn, Andreas

    2016-01-01

    It is well established that local field potentials (LFP) in the rodent olfactory bulb (OB) follow respiration. This respiration-related rhythm (RR) in OB depends on nasal air flow, indicating that it is conveyed by sensory inputs from the nasal epithelium. Recently RR was found outside the olfactory system, suggesting that it plays a role in organizing distributed network activity. It is therefore important to measure RR and to delineate it from endogenous electrical rhythms like theta which cover similar frequency bands in small rodents. In order to validate such measurements in freely behaving mice, we compared rhythmic LFP in the OB with two respiration-related biophysical parameters: whole-body plethysmography (PG) and nasal temperature (thermocouple; TC). During waking, all three signals reflected respiration with similar reliability. Peak power of RR in OB decreased with increasing respiration rate whereas power of PG increased. During NREM sleep, respiration-related TC signals disappeared and large amplitude slow waves frequently concealed RR in OB. In this situation, PG provided a reliable signal while breathing-related rhythms in TC and OB returned only during microarousals. In summary, local field potentials in the olfactory bulb do reliably reflect respiratory rhythm during wakefulness and REM sleep but not during NREM sleep. PMID:27247803

  19. Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice.

    PubMed

    Jessberger, Jakob; Zhong, Weiwei; Brankačk, Jurij; Draguhn, Andreas

    2016-01-01

    It is well established that local field potentials (LFP) in the rodent olfactory bulb (OB) follow respiration. This respiration-related rhythm (RR) in OB depends on nasal air flow, indicating that it is conveyed by sensory inputs from the nasal epithelium. Recently RR was found outside the olfactory system, suggesting that it plays a role in organizing distributed network activity. It is therefore important to measure RR and to delineate it from endogenous electrical rhythms like theta which cover similar frequency bands in small rodents. In order to validate such measurements in freely behaving mice, we compared rhythmic LFP in the OB with two respiration-related biophysical parameters: whole-body plethysmography (PG) and nasal temperature (thermocouple; TC). During waking, all three signals reflected respiration with similar reliability. Peak power of RR in OB decreased with increasing respiration rate whereas power of PG increased. During NREM sleep, respiration-related TC signals disappeared and large amplitude slow waves frequently concealed RR in OB. In this situation, PG provided a reliable signal while breathing-related rhythms in TC and OB returned only during microarousals. In summary, local field potentials in the olfactory bulb do reliably reflect respiratory rhythm during wakefulness and REM sleep but not during NREM sleep.

  20. Introduction to power-frequency electric and magnetic fields.

    PubMed Central

    Kaune, W T

    1993-01-01

    This paper introduces the reader to electric and magnetic fields, particularly those fields produced by electric power systems and other sources using frequencies in the power-frequency range. Electric fields are produced by electric charges; a magnetic field also is produced if these charges are in motion. Electric fields exert forces on other charges; if in motion, these charges will experience magnetic forces. Power-frequency electric and magnetic fields induce electric currents in conducting bodies such as living organisms. The current density vector is used to describe the distribution of current within a body. The surface of the human body is an excellent shield for power-frequency electric fields, but power-frequency magnetic fields penetrate without significant attenuation; the electric fields induced inside the body by either exposure are comparable in magnitude. Electric fields induced inside a human by most environmental electric and magnetic fields appear to be small in magnitude compared to levels naturally occurring in living tissues. Detection of such fields thus would seem to require the existence of unknown biological mechanisms. Complete characterization of a power-frequency field requires measurement of the magnitudes and electrical phases of the fundamental and harmonic amplitudes of its three vector components. Most available instrumentation measures only a small subset, or some weighted average, of these quantities. Hand-held survey meters have been used widely to measure power-frequency electric and magnetic fields. Automated data-acquisition systems have come into use more recently to make electric- and magnetic-field recordings, covering periods of hours to days, in residences and other environments.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8206045

  1. Mapping absolute tissue endogenous fluorophore concentrations with chemometric wide-field fluorescence microscopy

    NASA Astrophysics Data System (ADS)

    Xu, Zhang; Reilley, Michael; Li, Run; Xu, Min

    2017-06-01

    We report chemometric wide-field fluorescence microscopy for imaging the spatial distribution and concentration of endogenous fluorophores in thin tissue sections. Nonnegative factorization aided by spatial diversity is used to learn both the spectral signature and the spatial distribution of endogenous fluorophores from microscopic fluorescence color images obtained under broadband excitation and detection. The absolute concentration map of individual fluorophores is derived by comparing the fluorescence from "pure" fluorophores under the identical imaging condition following the identification of the fluorescence species by its spectral signature. This method is then demonstrated by characterizing the concentration map of endogenous fluorophores (including tryptophan, elastin, nicotinamide adenine dinucleotide, and flavin adenine dinucleotide) for lung tissue specimens. The absolute concentrations of these fluorophores are all found to decrease significantly from normal, perilesional, to cancerous (squamous cell carcinoma) tissue. Discriminating tissue types using the absolute fluorophore concentration is found to be significantly more accurate than that achievable with the relative fluorescence strength. Quantification of fluorophores in terms of the absolute concentration map is also advantageous in eliminating the uncertainties due to system responses or measurement details, yielding more biologically relevant data, and simplifying the assessment of competing imaging approaches.

  2. The history of fever, leukocytic pyrogen and interleukin-1.

    PubMed

    Dinarello, Charles A

    2015-01-01

    There has been great progress in the 30 y since the reporting in 1984 of the cDNA for interleukin1 (IL1) β in the human and IL1α in the mouse. However, the history of IL1 begins in the early 1940s with investigations into the nature of an endogenous fever-producing protein released rabbit peritoneal neutrophils. Most researchers in immunology today are unaware that the field of cytokines, particularly the field of inflammatory cytokines. Toll-like receptors and innate immunity traces back to studies on fever. Researchers in infectious diseases wanted to know about an endogenous protein that caused fever, independent of infection. The endogenous fever-producing protein was called by various names: granulocyte, endogenous or leukocytic pyrogen. It is a fascinating and sometimes controversial story for biology and medicine and for the treatment of inflammatory diseases. Few imagined that this fever-producing protein would play such a major role in nearly every cell and in most diseases. This paper reviews the true background and milestones of interleukin1 from the purification of leukocytic pyrogen to the first cDNA of IL1β and the validation of cytokine biology from ill-defined factors to its present day importance.

  3. Saturation of the Electric Field Transmitted to the Magnetosphere

    NASA Technical Reports Server (NTRS)

    Lyatsky, Wladislaw; Khazanov, George V.; Slavin, James A.

    2010-01-01

    We reexamined the processes leading to saturation of the electric field, transmitted into the Earth's ionosphere from the solar wind, incorporating features of the coupled system previously ignored. We took into account that the electric field is transmitted into the ionosphere through a region of open field lines, and that the ionospheric conductivity in the polar cap and auroral zone may be different. Penetration of the electric field into the magnetosphere is linked with the generation of the Alfven wave, going out from the ionosphere into the solar wind and being coupled with the field-aligned currents at the boundary of the open field limes. The electric field of the outgoing Alfven wave reduces the original electric field and provides the saturation effect in the electric field and currents during strong geomagnetic disturbances, associated with increasing ionospheric conductivity. The electric field and field-aligned currents of this Alfven wave are dependent on the ionospheric and solar wind parameters and may significantly affect the electric field and field-aligned currents, generated in the polar ionosphere. Estimating the magnitude of the saturation effect in the electric field and field-aligned currents allows us to improve the correlation between solar wind parameters and resulting disturbances in the Earth's magnetosphere.

  4. Endogenous opiates and behavior: 2008.

    PubMed

    Bodnar, Richard J

    2009-12-01

    This paper is the 31st consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2008 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior (Section 2), and the roles of these opioid peptides and receptors in pain and analgesia (Section 3); stress and social status (Section 4); tolerance and dependence (Section 5); learning and memory (Section 6); eating and drinking (Section 7); alcohol and drugs of abuse (Section 8); sexual activity and hormones, pregnancy, development and endocrinology (Section 9); mental illness and mood (Section 10); seizures and neurologic disorders (Section 11); electrical-related activity and neurophysiology (Section 12); general activity and locomotion (Section 13); gastrointestinal, renal and hepatic functions (Section 14); cardiovascular responses (Section 15); respiration and thermoregulation (Section 16); and immunological responses (Section 17).

  5. Effects of ionotropic glutamate receptor antagonists on rat dural artery diameter in an intravital microscopy model.

    PubMed

    Chan, K Y; Gupta, S; de Vries, R; Danser, A H J; Villalón, C M; Muñoz-Islas, E; Maassenvandenbrink, A

    2010-07-01

    During migraine, trigeminal nerves may release calcitonin gene-related peptide (CGRP), inducing cranial vasodilatation and central nociception; hence, trigeminal inhibition or blockade of craniovascular CGRP receptors may prevent this vasodilatation and abort migraine headache. Several preclinical studies have shown that glutamate receptor antagonists affect the pathophysiology of migraine. This study investigated whether antagonists of NMDA (ketamine and MK801), AMPA (GYKI52466) and kainate (LY466195) glutamate receptors affected dural vasodilatation induced by alpha-CGRP, capsaicin and periarterial electrical stimulation in rats, using intravital microscopy. Male Sprague-Dawley rats were anaesthetized and the overlying bone was thinned to visualize the dural artery. Then, vasodilator responses to exogenous (i.v. alpha-CGRP) and endogenous (released by i.v. capsaicin and periarterial electrical stimulation) CGRP were elicited in the absence or presence of the above antagonists. alpha-CGRP, capsaicin and periarterial electrical stimulation increased dural artery diameter. Ketamine and MK801 inhibited the vasodilator responses to capsaicin and electrical stimulation, while only ketamine attenuated those to alpha-CGRP. In contrast, GYKI52466 only attenuated the vasodilatation to exogenous alpha-CGRP, while LY466195 did not affect the vasodilator responses to endogenous or exogenous CGRP. Although GYKI52466 has not been tested clinically, our data suggest that it would not inhibit migraine via vascular mechanisms. Similarly, the antimigraine efficacy of LY466195 seems unrelated to vascular CGRP-mediated pathways and/or receptors. In contrast, the cranial vascular effects of ketamine and MK801 may represent a therapeutic mechanism, although the same mechanism might contribute, peripherally, to cardiovascular side effects.

  6. Laser-driven electron acceleration in a plasma channel with an additional electric field

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cheng, Li-Hong; Xue, Ju-Kui, E-mail: xuejk@nwnu.edu.cn; Liu, Jie, E-mail: liu-jie@iapcm.ac.cn

    2016-05-15

    We examine the electron acceleration in a two-dimensional plasma channel under the action of a laser field and an additional static electric field. We propose to design an appropriate additional electric field (its direction and location), in order to launch the electron onto an energetic trajectory. We find that the electron acceleration strongly depends on the coupled effects of the laser polarization, the direction, and location of the additional electric field. The additional electric field affects the electron dynamics by changing the dephasing rate. Particularly, a suitably designed additional electric field leads to a considerable energy gain from the lasermore » pulse after the interaction with the additional electric field. The electron energy gain from the laser with the additional electric field can be much higher than that without the additional electric field. This engineering provides a possible means for producing high energetic electrons.« less

  7. Auroral zone electric fields from DE 1 and 2 at magnetic conjunctions

    NASA Technical Reports Server (NTRS)

    Weimer, D. R.; Goertz, C. K.; Gurnett, D. A.; Maynard, N. C.; Burch, J. L.

    1985-01-01

    Nearly simultaneous measurements of auroral zone electric fields are obtained by the Dynamics Explorer spacecraft at altitudes below 900 km and above 4,500 km during magnetic conjunctions. The measured electric fields are usually perpendicular to the magnetic field lines. The north-south meridional electric fields are projected to a common altitude by a mapping function which accounts for the convergence of the magnetic field lines. When plotted as a function of invariant latitude, graphs of the projected electric fields measured by both DE-1 and DE-2 show that the large-scale electric field is the same at both altitudes, as expected. Superimposed on the large-scale fields, however, are small-scale features with wavelengths less than 100 km which are larger in magnitude at the higher altitude. Fourier transforms of the electric fields show that the magnitudes depend on wavelength. Outside of the auroral zone the electric field spectrums are nearly identical. But within the auroral zone the high and low altitude electric fields have a ratio which increases with the reciprocal of the wavelength. The small-scale electric field variations are associated with field-aligned currents. These currents are measured with both a plasma instrument and magnetometer on DE-1.

  8. Analysis of Surface Electric Field Measurements from an Array of Electric Field Mills

    NASA Astrophysics Data System (ADS)

    Lucas, G.; Thayer, J. P.; Deierling, W.

    2016-12-01

    Kennedy Space Center (KSC) has operated an distributed array of over 30 electric field mills over the past 18 years, providing a unique data set of surface electric field measurements over a very long timespan. In addition to the electric field instruments there are many meteorological towers around KSC that monitor the local meteorological conditions. Utilizing these datasets we have investigated and found unique spatial and temporal signatures in the electric field data that are attributed to local meteorological effects and the global electric circuit. The local and global scale influences on the atmospheric electric field will be discussed including the generation of space charge from the ocean surf, local cloud cover, and a local enhancement in the electric field that is seen at sunrise.

  9. The effect of pulsed electric fields on the electrotactic migration of human neural progenitor cells through the involvement of intracellular calcium signaling.

    PubMed

    Hayashi, Hisamitsu; Edin, Fredrik; Li, Hao; Liu, Wei; Rask-Andersen, Helge

    2016-12-01

    Endogenous electric fields (EFs) are required for the physiological control of the central nervous system development. Application of the direct current EFs to neural stem cells has been studied for the possibility of stem cell transplantation as one of the therapies for brain injury. EFs generated within the nervous system are often associated with action potentials and synaptic activity, apparently resulting in a pulsed current in nature. The aim of this study is to investigate the effect of pulsed EF, which can reduce the cytotoxicity, on the migration of human neural progenitor cells (hNPCs). We applied the mono-directional pulsed EF with a strength of 250mV/mm to hNPCs for 6h. The migration distance of the hNPCs exposed to pulsed EF was significantly greater compared with the control not exposed to the EF. Pulsed EFs, however, had less of an effect on the migration of the differentiated hNPCs. There was no significant change in the survival of hNPCs after exposure to the pulsed EF. To investigate the role of Ca 2+ signaling in electrotactic migration of hNPCs, pharmacological inhibition of Ca 2+ channels in the EF-exposed cells revealed that the electrotactic migration of hNPCs exposed to Ca 2+ channel blockers was significantly lower compared to the control group. The findings suggest that the pulsed EF induced migration of hNPCs is partly influenced by intracellular Ca 2+ signaling. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Effects of direct current electric fields on lung cancer cell electrotaxis in a PMMA-based microfluidic device.

    PubMed

    Li, Yaping; Xu, Tao; Chen, Xiaomei; Lin, Shin; Cho, Michael; Sun, Dong; Yang, Mengsu

    2017-03-01

    Tumor metastasis is the primary cause of cancer death. Numerous studies have demonstrated the electrotactic responses of various cancer cell types, and suggested its potential implications in metastasis. In this study, we used a microfluidic device to emulate endogenous direct current electric field (dcEF) environment, and studied the electrotactic migration of non-small cell lung cancer cell lines (H460, HCC827, H1299, and H1975) and the underlying mechanisms. These cell lines exhibited greatly different response in applied dcEFs (2-6 V/cm). While H460 cells (large cell carcinoma) showed slight migration toward cathode, H1299 cells (large cell carcinoma) showed increased motility and dcEF-dependent anodal migration with cell reorientation. H1975 cells (adenocarcinoma) showed dcEF-dependent cathodal migration with increased motility, and HCC827 cells (adenocarcinoma) responded positively in migration speed and reorientation but minimally in migrating directions to dcEF. Activation of MAPK and PI3K signaling pathways was found to be associated with the realignment and directed migration of lung cancer cells. In addition, both Ca 2+ influx through activated stretch-activated calcium channels (SACCs) (but not voltage-gated calcium channels, VGCCs) and Ca 2+ release from intracellular storage were involved in lung cancer cell electrotactic responses. The results demonstrated that the microfluidic device provided a stable and controllable microenvironment for cell electrotaxis study, and revealed that the electrotactic responses of lung cancer cells were heterogeneous and cell-type dependent, and multiple signals contributed to lung cancer cells electrotaxis.

  11. Preliminary Findings from the One-Year Electric Field Study in the North Slope of Alaska (OYES-NSA), Atmospheric Radiation Measurement (ARM) Field Campaign

    NASA Astrophysics Data System (ADS)

    Lavigne, T.; Liu, C.

    2017-12-01

    Previous studies focusing on the comparison of the measured electric field to the physical properties of global electrified clouds have been conducted almost exclusively in the Southern Hemisphere. The One-Year Electric Field Study-North Slope of Alaska (OYES-NSA) aims to establish a long-running collection of this valuable electric field data in the Northern Hemisphere. Presented here is the six-month preliminary data and results of the OYES-NSA Atmospheric Radiation Mission (ARM) field campaign. The local electric field measured in Barrow, Alaska using two CS110 reciprocating shutter field meters, has been compared to simultaneous measurements from the ARM Ka-Band zenith radar, to better understand the influence and contribution of different types of clouds on the local electric field. The fair-weather electric field measured in Barrow has also been analyzed and compared to the climatology of electric field at Vostok Station, Antarctica. The combination of the electric field dataset in the Northern Hemisphere, alongside the local Ka cloud radar, global Precipitation Feature (PF) database, and quasi-global lightning activity (55oN-55oS), allows for advances in the physical understanding of the local electric field, as well as the Global Electric Circuit (GEC).

  12. Why acupuncture in pain treatment?

    PubMed

    Ondrejkovicova, Alena; Petrovics, Gabriel; Svitkova, Katarína; Bajtekova, Bibiana; Bangha, Ondrej

    2016-07-01

    Acupuncture is one of the branches of Chinese Traditional Medicine dating back almost 5 000 years. The expansion of China's trade and business relations with other Asian countries brought about the spreading of acupuncture in 7th Century. Nowadays, acupuncture is an interdisciplinary clinical field of Medicine dealing with treatment, diagnostics and prevention of mainly functional disorders, algic, allergic and addictive conditions of various etiology, localization and intensity. It draws from the millennia of experience of Oriental Medicine as well as contemporary knowledge of morphology, physiology and neurophysiology. The acupuncture method is based on influencing the body functions in a precise way by controlled irritation of particular active meridian points using special needles, heat (moxibustion), pressure (acupressure), underpressure (cupping), electricity (electroacupuncture), light (laser therapy), ultrasound (sonopuncture), static or pulsating electromagnetic field (magnetic therapy) and solutions (pharmacopuncture).The use of acupuncture as a method of pain relief in Modern Western Medicine is based on a wide range of clinical trials, and there is no doubt that it has significant effect in the treatment of acute and chronic pain classification. The introduction of gate-control theory and endogenous opioids facilitated the recognition of acupuncture in pain treatment.

  13. Age-dependent changes of presynaptic neuromodulation via A1-adenosine receptors in rat hippocampal slices.

    PubMed

    Sperlágh, B; Zsilla, G; Baranyi, M; Kékes-Szabó, A; Vizi, E S

    1997-10-01

    The presynaptic neuromodulation of stimulation-evoked release of [3H]-acetylcholine by endogenous adenosine, via A1-adenosine receptors, was studied in superfused hippocampal slices taken from 4-, 12- and 24-month-old rats. 8-Cyclopentyl-1,3-dimethylxanthine (0.25 microM), a selective A1-receptor antagonist, increased significantly the electrical field stimulation-induced release of [3H]-acetylcholine in slices prepared from 4- and 12-month-old rats, showing a tonic inhibitory action of endogenous adenosine via stimulation of presynaptic A1-adenosine receptors. In contrast, 8-cyclopentyl-1,3-dimethylxanthine had no effect in 24-month-old rats. 2-Chloroadenosine (10 microM), an adenosine receptor agonist decreased the release of [3H]-acetylcholine in slices taken from 4- and 12-month-old rats, and no significant change was observed in slices taken from 24-month-old rats. In order to show whether the number/or affinity of the A1-receptors was affected in aged rats, [3H]-8-cyclopentyl-1,3-dimethylxanthine binding was studied in hippocampal membranes prepared from rats of different ages. Whereas the Bmax value was significantly lower in 2-year-old rats than in younger counterparts, the dissociation constant (Kd) was not affected by aging, indicating that the density rather than the affinity of adenosine receptors was altered. Endogenous adenosine levels present in the extracellular space were also measured in the superfusate by high performance liquid chromatography (HPLC) coupled with ultraviolet detection, and an age-related increase in the adenosine level was found. In summary, our results indicate that during aging the level of adenosine in the extracellular fluid is increased in the hippocampus. There is a downregulation and reduced responsiveness of presynaptic adenosine A1-receptors, and it seems likely that these changes are due to the enhanced adenosine level in the extracellular space.

  14. Engineering and commercialization of human-device interfaces, from bone to brain.

    PubMed

    Knothe Tate, Melissa L; Detamore, Michael; Capadona, Jeffrey R; Woolley, Andrew; Knothe, Ulf

    2016-07-01

    Cutting edge developments in engineering of tissues, implants and devices allow for guidance and control of specific physiological structure-function relationships. Yet the engineering of functionally appropriate human-device interfaces represents an intractable challenge in the field. This leading opinion review outlines a set of current approaches as well as hurdles to design of interfaces that modulate transfer of information, i.a. forces, electrical potentials, chemical gradients and haptotactic paths, between endogenous and engineered body parts or tissues. The compendium is designed to bridge across currently separated disciplines by highlighting specific commonalities between seemingly disparate systems, e.g. musculoskeletal and nervous systems. We focus on specific examples from our own laboratories, demonstrating that the seemingly disparate musculoskeletal and nervous systems share common paradigms which can be harnessed to inspire innovative interface design solutions. Functional barrier interfaces that control molecular and biophysical traffic between tissue compartments of joints are addressed in an example of the knee. Furthermore, we describe the engineering of gradients for interfaces between endogenous and engineered tissues as well as between electrodes that physically and electrochemically couple the nervous and musculoskeletal systems. Finally, to promote translation of newly developed technologies into products, protocols, and treatments that benefit the patients who need them most, regulatory and technical challenges and opportunities are addressed on hand from an example of an implant cum delivery device that can be used to heal soft and hard tissues, from brain to bone. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

  15. Neuron matters: electric activation of neuronal tissue is dependent on the interaction between the neuron and the electric field.

    PubMed

    Ye, Hui; Steiger, Amanda

    2015-08-12

    In laboratory research and clinical practice, externally-applied electric fields have been widely used to control neuronal activity. It is generally accepted that neuronal excitability is controlled by electric current that depolarizes or hyperpolarizes the excitable cell membrane. What determines the amount of polarization? Research on the mechanisms of electric stimulation focus on the optimal control of the field properties (frequency, amplitude, and direction of the electric currents) to improve stimulation outcomes. Emerging evidence from modeling and experimental studies support the existence of interactions between the targeted neurons and the externally-applied electric fields. With cell-field interaction, we suggest a two-way process. When a neuron is positioned inside an electric field, the electric field will induce a change in the resting membrane potential by superimposing an electrically-induced transmembrane potential (ITP). At the same time, the electric field can be perturbed and re-distributed by the cell. This cell-field interaction may play a significant role in the overall effects of stimulation. The redistributed field can cause secondary effects to neighboring cells by altering their geometrical pattern and amount of membrane polarization. Neurons excited by the externally-applied electric field can also affect neighboring cells by ephaptic interaction. Both aspects of the cell-field interaction depend on the biophysical properties of the neuronal tissue, including geometric (i.e., size, shape, orientation to the field) and electric (i.e., conductivity and dielectricity) attributes of the cells. The biophysical basis of the cell-field interaction can be explained by the electromagnetism theory. Further experimental and simulation studies on electric stimulation of neuronal tissue should consider the prospect of a cell-field interaction, and a better understanding of tissue inhomogeneity and anisotropy is needed to fully appreciate the neural basis of cell-field interaction as well as the biological effects of electric stimulation.

  16. Simple estimation of induced electric fields in nervous system tissues for human exposure to non-uniform electric fields at power frequency

    NASA Astrophysics Data System (ADS)

    Tarao, Hiroo; Miyamoto, Hironobu; Korpinen, Leena; Hayashi, Noriyuki; Isaka, Katsuo

    2016-06-01

    Most results regarding induced current in the human body related to electric field dosimetry have been calculated under uniform field conditions. We have found in previous work that a contact current is a more suitable way to evaluate induced electric fields, even in the case of exposure to non-uniform fields. If the relationship between induced currents and external non-uniform fields can be understood, induced electric fields in nervous system tissues may be able to be estimated from measurements of ambient non-uniform fields. In the present paper, we numerically calculated the induced electric fields and currents in a human model by considering non-uniform fields based on distortion by a cubic conductor under an unperturbed electric field of 1 kV m-1 at 60 Hz. We investigated the relationship between a non-uniform external electric field with no human present and the induced current through the neck, and the relationship between the current through the neck and the induced electric fields in nervous system tissues such as the brain, heart, and spinal cord. The results showed that the current through the neck can be formulated by means of an external electric field at the central position of the human head, and the distance between the conductor and the human model. As expected, there is a strong correlation between the current through the neck and the induced electric fields in the nervous system tissues. The combination of these relationships indicates that induced electric fields in these tissues can be estimated solely by measurements of the external field at a point and the distance from the conductor.

  17. Spherical Ethylene/Air Diffusion Flames Subject to Concentric DC Electric Field in Microgravity

    NASA Technical Reports Server (NTRS)

    Yuan, Z. -G.; Hegde, U.; Faeth, G. M.

    2001-01-01

    It is well known that microgravity conditions, by eliminating buoyant flow, enable many combustion phenomena to be observed that are not possible to observe at normal gravity. One example is the spherical diffusion flame surrounding a porous spherical burner. The present paper demonstrates that by superimposing a spherical electrical field on such a flame, the flame remains spherical so that we can study the interaction between the electric field and flame in a one-dimensional fashion. Flames are susceptible to electric fields that are much weaker than the breakdown field of the flame gases owing to the presence of ions generated in the high temperature flame reaction zone. These ions and the electric current of the moving ions, in turn, significantly change the distribution of the electric field. Thus, to understand the interplay between the electric field and the flame is challenging. Numerous experimental studies of the effect of electric fields on flames have been reported. Unfortunately, they were all involved in complex geometries of both the flow field and the electric field, which hinders detailed study of the phenomena. In a one-dimensional domain, however, the electric field, the flow field, the thermal field and the chemical species field are all co-linear. Thus the problem is greatly simplified and becomes more tractable.

  18. Study of electric field distorted by space charges under positive lightning impulse voltage

    NASA Astrophysics Data System (ADS)

    Wang, Zezhong; Geng, Yinan

    2018-03-01

    Actually, many insulation problems are related to electric fields. And measuring electric fields is an important research topic of high-voltage engineering. In particular, the electric field distortion caused by space charge is the basis of streamer theory, and thus quantitatively measuring the Poisson electric field caused by space charge is significant to researching the mechanism of air gap discharge. In this paper, we used our photoelectric integrated sensor to measure the electric field distribution in a 1-m rod-plane gap under positive lightning impulse voltage. To verify the reliability of this quantitative measurement, we compared the measured results with calculated results from a numerical simulation. The electric-field time domain waveforms on the axis of the 1-m rod-plane out of the space charge zone were measured with various electrodes. The Poisson electric fields generated by space charge were separated from the Laplace electric field generated by applied voltages, and the amplitudes and variations were measured for various applied voltages and at various locations. This work also supplies the feasible basis for directly measuring strong electric field under high voltage.

  19. Wireless Chemical Sensor and Sensing Method for Use Therewith

    NASA Technical Reports Server (NTRS)

    Oglesby, Donald M. (Inventor); Taylor, Bryant D. (Inventor); Woodard, Stanley E. (Inventor)

    2016-01-01

    A wireless chemical sensor includes an electrical conductor and a material separated therefrom by an electric insulator. The electrical conductor is an unconnected open-circuit shaped for storage of an electric field and a magnetic field. In the presence of a time-varying magnetic field, the first electrical conductor resonates to generate harmonic electric and magnetic field responses. The material is positioned at a location lying within at least one of the electric and magnetic field responses so-generated. The material changes in electrical conductivity in the presence of a chemical-of-interest.

  20. Wireless Chemical Sensor and Sensing Method for Use Therewith

    NASA Technical Reports Server (NTRS)

    Woodard, Stanley E. (Inventor); Oglesby, Donald M. (Inventor); Taylor, Bryant Douglas (Inventor)

    2014-01-01

    A wireless chemical sensor includes an electrical conductor and a material separated therefrom by an electric insulator. The electrical conductor is an unconnected open-circuit shaped for storage of an electric field and a magnetic field. In the presence of a time-varying magnetic field, the first electrical conductor resonates to generate harmonic electric and magnetic field responses. The material is positioned at a location lying within at least one of the electric and magnetic field responses so-generated. The material changes in electrical conductivity in the presence of a chemical-of-interest.

  1. Wireless Chemical Sensing Method

    NASA Technical Reports Server (NTRS)

    Taylor, Bryant D. (Inventor); Woodard, Stanley E. (Inventor); Oglesby, Donald M. (Inventor)

    2017-01-01

    A wireless chemical sensor includes an electrical conductor and a material separated therefrom by an electric insulator. The electrical conductor is an unconnected open-circuit shaped for storage of an electric field and a magnetic field. In the presence of a time-varying magnetic field, the first electrical conductor resonates to generate harmonic electric and magnetic field responses. The material is positioned at a location lying within at least one of the electric and magnetic field responses so-generated. The material changes in electrical conductivity in the presence of a chemical-of-interest.

  2. Giant Electric Field Enhancement in Split Ring Resonators Featuring Nanometer-Sized Gaps

    NASA Astrophysics Data System (ADS)

    Bagiante, S.; Enderli, F.; Fabiańska, J.; Sigg, H.; Feurer, T.

    2015-01-01

    Today's pulsed THz sources enable us to excite, probe, and coherently control the vibrational or rotational dynamics of organic and inorganic materials on ultrafast time scales. Driven by standard laser sources THz electric field strengths of up to several MVm-1 have been reported and in order to reach even higher electric field strengths the use of dedicated electric field enhancement structures has been proposed. Here, we demonstrate resonant electric field enhancement structures, which concentrate the incident electric field in sub-diffraction size volumes and show an electric field enhancement as high as ~14,000 at 50 GHz. These values have been confirmed through a combination of near-field imaging experiments and electromagnetic simulations.

  3. Biological and Agricultural Studies on Application of Discharge Plasma and Electromagnetic Fields 5. Effects of High Electric Fields on Animals

    NASA Astrophysics Data System (ADS)

    Isaka, Katsuo

    The biological effects of extremely low frequency electric fields on animals are reviewed with emphasis on studies of the nervous system, behavior, endocrinology, and blood chemistry. First, this paper provides a histrical overview of studies on the electric field effects initiated in Russia and the United States mainly regarding electric utility workers in high voltage substations and transmission lines. Then, the possible mechanisms of electric field effects are explained using the functions of surface electric fields and induced currents in biological objects. The real mechanisms have not yet been identified. The thresholds of electric field perception levels for rats, baboons, and humans are introduced and compared. The experimental results concerning the depression of melatonin secretion in rats exposed to electric fields are described.

  4. Magnetospheric electric fields and currents

    NASA Technical Reports Server (NTRS)

    Mauk, B. H.; Zanetti, L. J.

    1987-01-01

    The progress made in the years 1983-1986 in understanding the character and operation of magnetospheric electric fields and electric currents is discussed, with emphasis placed on the connection with the interior regions. Special attention is given to determinations of global electric-field configurations, measurements of the response of magnetospheric particle populations to the electric-field configurations, and observations of the magnetospheric currents at high altitude and during northward IMF. Global simulations of current distributions are discussed, and the sources of global electric fields and currents are examined. The topics discussed in the area of impulsive and small-scale phenomena include substorm current systems, impulsive electric fields and associated currents, and field-aligned electrodynamics. A key finding of these studies is that the electric fields and currents are interrelated and cannot be viewed as separate entities.

  5. Phenotypically silent Cre recombination within the postnatal ventricular conduction system.

    PubMed

    Bhattacharyya, Samadrita; Bhakta, Minoti; Munshi, Nikhil Vilas

    2017-01-01

    The cardiac conduction system (CCS) is composed of specialized cardiomyocytes that initiate and maintain cardiac rhythm. Any perturbation to the normal sequence of electrical events within the heart can result in cardiac arrhythmias. To understand how cardiac rhythm is established at the molecular level, several genetically modified mouse lines expressing Cre recombinase within specific CCS compartments have been created. In general, Cre driver lines have been generated either by homologous recombination of Cre into an endogenous locus or Cre expression driven by a randomly inserted transgene. However, haploinsufficiency of the endogenous gene compromises the former approach, while position effects negatively impact the latter. To address these limitations, we generated a Cre driver line for the ventricular conduction system (VCS) that preserves endogenous gene expression by targeting the Contactin2 (Cntn2) 3' untranslated region (3'UTR). Here we show that Cntn23'UTR-IRES-Cre-EGFP/+ mice recombine floxed alleles within the VCS and that Cre expression faithfully recapitulates the spatial distribution of Cntn2 within the heart. We further demonstrate that Cre expression initiates after birth with preservation of native Cntn2 protein. Finally, we show that Cntn23'UTR-IRES-Cre-EGFP/+ mice maintain normal cardiac mechanical and electrical function. Taken together, our results establish a novel VCS-specific Cre driver line without the adverse consequences of haploinsufficiency or position effects. We expect that our new mouse line will add to the accumulating toolkit of CCS-specific mouse reagents and aid characterization of the cell-autonomous molecular circuitry that drives VCS maintenance and function.

  6. Molecules with an induced dipole moment in a stochastic electric field.

    PubMed

    Band, Y B; Ben-Shimol, Y

    2013-10-01

    The mean-field dynamics of a molecule with an induced dipole moment (e.g., a homonuclear diatomic molecule) in a deterministic and a stochastic (fluctuating) electric field is solved to obtain the decoherence properties of the system. The average (over fluctuations) electric dipole moment and average angular momentum as a function of time for a Gaussian white noise electric field are determined via perturbative and nonperturbative solutions in the fluctuating field. In the perturbative solution, the components of the average electric dipole moment and the average angular momentum along the deterministic electric field direction do not decay to zero, despite fluctuations in all three components of the electric field. This is in contrast to the decay of the average over fluctuations of a magnetic moment in a Gaussian white noise magnetic field. In the nonperturbative solution, the component of the average electric dipole moment and the average angular momentum in the deterministic electric field direction also decay to zero.

  7. The relationship between anatomically correct electric and magnetic field dosimetry and publishe delectric and magnetic field exposure limits.

    PubMed

    Kavet, Robert; Dovan, Thanh; Reilly, J Patrick

    2012-12-01

    Electric and magnetic field exposure limits published by International Commission for Non-Ionizing Radiation Protection and Institute of Electrical and Electronics Engineers are aimed at protection against adverse electrostimulation, which may occur by direct coupling to excitable tissue and, in the case of electric fields, through indirect means associated with surface charge effects (e.g. hair vibration, skin sensations), spark discharge and contact current. For direct coupling, the basic restriction (BR) specifies the not-to-be-exceeded induced electric field. The key results of anatomically based electric and magnetic field dosimetry studies and the relevant characteristics of excitable tissue were first identified. This permitted us to assess the electric and magnetic field exposure levels that induce dose in tissue equal to the basic restrictions, and the relationships of those exposure levels to the limits now in effect. We identify scenarios in which direct coupling of electric fields to peripheral nerve could be a determining factor for electric field limits.

  8. Cloaking magnetic field and generating electric field with topological insulator and superconductor bi-layer sphere

    NASA Astrophysics Data System (ADS)

    Xu, Jin

    2017-12-01

    When an electric field is applied on a topological insulator, not only the electric field is generated, but also the magnetic field is generated, vice versa. I designed topological insulator and superconductor bi-layer magnetic cloak, derived the electric field and magnetic field inside and outside the topological insulator and superconductor sphere. Simulation and calculation results show that the applied magnetic field is screened by the topological insulator and superconductor bi-layer, and the electric field is generated in the cloaked region.

  9. Electric Field Feature of Moving Magnetic Field

    NASA Astrophysics Data System (ADS)

    Chen, You Jun

    2001-05-01

    A new fundamental relationship of electric field with magnetic field has been inferred from the fundamental experimental laws and theories of classical electromagnetics. It can be described as moving magnetic field has or gives electric feature. When a field with magnetic induction of B moves in the velocity of V, it will show electric field character, the electric field intensity E is E = B x V and the direction of E is in the direction of the vector B x V. It is improper to use the time-varying electromagnetics theories as the fundamental theory of the electromagnetics and group the electromagnetic field into static kind and time-varying kind for the static is relative to motional not only time-varying. The relationship of time variation of magnetic field induction or magnetic flux with electric field caused by magnetic field is fellowship not causality. Thus time-varying magnetic field can cause electric field is not a nature principle. Sometime the time variation of magnetic flux is equal to the negative electromotive force or the time variation of magnetic field induction is equal to the negative curl of electric field caused by magnetic field motion, but not always. And not all motion of magnetic field can cause time variation of magnetic field. Therefore Faraday-Lenz`s law can only be used as mathematics tool to calculate the quantity relation of the electricity with the magnetism in some case like the magnetic field moving in uniform medium. Faraday-Lenz`s law is unsuitable to be used in moving uniform magnetic field or there is magnetic shield. Key word: Motional magnetic field, Magnetic induction, Electric field intensity, Velocity, Faraday-Lenz’s law

  10. Endogenous sex steroids and cardio- and cerebro-vascular disease in the postmenopausal period.

    PubMed

    Pappa, Theodora; Alevizaki, Maria

    2012-08-01

    Cardio- and cerebro-vascular diseases are two leading causes of death and long-term disability in postmenopausal women. The acute fall of estrogen in menopause is associated with increased cardiovascular risk. The relative contribution of androgen to this risk is also being recognized. The use of more sensitive assays for estradiol measurement and the study of receptor and carrier protein gene polymorphisms have provided some new information on the clinical relevance of endogenous sex steroids. We provide an update on the role of endogenous sex steroids on cardio- and cerebro-vascular disease in the postmenopausal period. We performed a PubMed search using the terms 'endogenous estrogen', 'androgen', 'cardiovascular disease', 'cerebro-vascular disease', 'stroke', 'carotid artery disease', and 'subclinical atherosclerosis'. The majority of studies show a beneficial effect of endogenous estrogen on the vasculature; however, there are a few studies reporting the contrary. A significant body of literature has reported associations of endogenous estrogen and androgen with early markers of atherosclerosis and metabolic parameters. Data on the relevance of endogenous sex steroids in heart disease and stroke are inconclusive. Most studies support a beneficial role of endogenous estrogens and, probably, an adverse effect of androgens in the vasculature in postmenopausal women. However, the described associations may not always be considered as causal. It is possible that circulating estrogen might represent a marker of general health status or alternatively reflect the sum of endogenous androgens aromatized in the periphery. Elucidating the role of sex steroids in cardio- and cerebro-vascular disease remains an interesting field of future research.

  11. Processes in suspensions of nanocomposite microcapsules exposed to external electric fields

    NASA Astrophysics Data System (ADS)

    Ermakov, A. V.; Lomova, M. V.; Kim, V. P.; Chumakov, A. S.; Gorbachev, I. A.; Gorin, D. A.; Glukhovskoy, E. G.

    2016-04-01

    Microcapsules with and without magnetite nanoparticles incorporated in the polyelectrolyte shell were prepared. The effect of external electric field on the nanocomposite polyelectrolyte microcapsules containing magnetite nanoparticles in the shell was studied in this work as a function of the electric field strength. Effect of electric fields on polyelectrolyte microcapsules and the control over integrity of polyelectrolyte microcapsules with and without inorganic nanoparticles by constant electric field has been investigated. Beads effect, aggregation and deformations of nanocomposite microcapsule shell in response to electric field were observed by confocal laser scanning microscopy (CLSM). Thus, a new approach for effect on the nanocomposite microcapsule, including opening microcapsule shell by an electric field, was demonstrated. These results can be used for creation of new systems for drug delivery systems with controllable release by external electric field.

  12. On high-latitude convection field inhomogeneities, parallel electric fields and inverted-V precipitation events

    NASA Technical Reports Server (NTRS)

    Lennartsson, W.

    1977-01-01

    A simple model of a static electric field with a component parallel to the magnetic field is proposed for calculating the electric field and current distributions at various altitudes when the horizontal distribution of the convection electric field is given at a certain altitude above the auroral ionosphere. The model is shown to be compatible with satellite observations of inverted-V electron precipitation structures and associated irregularities in the convection electric field.

  13. Permanent magnetic field, direct electric field, and infrared to reduce blood glucose level and hepatic function in mus musculus with diabetic mellitus

    NASA Astrophysics Data System (ADS)

    Suhariningsih; Basuki Notobroto, Hari; Winarni, Dwi; Achmad Hussein, Saikhu; Anggono Prijo, Tri

    2017-05-01

    Blood contains several electrolytes with positive (cation) and negative (anion) ion load. Both electrolytes deliver impulse synergistically adjusting body needs. Those electrolytes give specific effect to external disturbance such as electric, magnetic, even infrared field. A study has been conducted to reduce blood glucose level and liver function, in type 2 Diabetes Mellitus patients, using Biophysics concept which uses combination therapy of permanent magnetic field, electric field, and infrared. This study used 48 healthy mice (mus musculus), male, age 3-4 weeks, with approximately 25-30 g in weight. Mice was fed with lard as high fat diet orally, before Streptozotocin (STZ) induction become diabetic mice. Therapy was conducted by putting mice in a chamber that emits the combination of permanent magnetic field, electric field, and infrared, every day for 1 hour for 28 days. There were 4 combinations of therapy/treatment, namely: (1) permanent magnetic field, direct electric field, and infrared; (2) permanent magnetic field, direct electric field, without infrared; (3) permanent magnetic field, alternating electric field, and infrared; and (4) permanent magnetic field, alternating electric field, without infrared. The results of therapy show that every combination is able to reduce blood glucose level, AST, and ALT. However, the best result is by using combination of permanent magnetic field, direct electric field, and infrared.

  14. High sensitive space electric field sensing based on micro fiber interferometer with field force driven gold nanofilm.

    PubMed

    Zhu, Tao; Zhou, Liming; Liu, Min; Zhang, Jingdong; Shi, Leilei

    2015-10-28

    The traditional electrical field sensing can be realized by utilizing electro-optic materials or liquid crystals, and has limitations of easy breakdown, free assembly and difficult measurement of low-frequency. Here, we propose a new method to realize safe measurement of spatial dynamic electric field by using a micro fiber interferometer integrated with gold nanofilm. The energy of the electric charge received through antenna forms the intrinsic electric field with two micro electrodes, one of which is the 120 nm gold film vibration beam micromachined by femtosecond lasers and integrated with the micro fiber. The change of the intrinsic electric field force due to the spatial electric field will cause the vibration of the film beam. By demodulating the output signal of the micro fiber interferometer, the electric field can be measured. We demonstrate the detectable frequency ranges from tens of Hz to tens of KHz, and the minimum electric field intensity is ~200 V/m at 1 KHz. Our electric field measurement technology combining optical fiber interference with gold nanostructures shows the advantages of security, high sensitivity, compact size, and multiplexed multi-point and remote detection.

  15. High sensitive space electric field sensing based on micro fiber interferometer with field force driven gold nanofilm

    PubMed Central

    Zhu, Tao; Zhou, Liming; Liu, Min; Zhang, Jingdong; Shi, Leilei

    2015-01-01

    The traditional electrical field sensing can be realized by utilizing electro-optic materials or liquid crystals, and has limitations of easy breakdown, free assembly and difficult measurement of low-frequency. Here, we propose a new method to realize safe measurement of spatial dynamic electric field by using a micro fiber interferometer integrated with gold nanofilm. The energy of the electric charge received through antenna forms the intrinsic electric field with two micro electrodes, one of which is the 120 nm gold film vibration beam micromachined by femtosecond lasers and integrated with the micro fiber. The change of the intrinsic electric field force due to the spatial electric field will cause the vibration of the film beam. By demodulating the output signal of the micro fiber interferometer, the electric field can be measured. We demonstrate the detectable frequency ranges from tens of Hz to tens of KHz, and the minimum electric field intensity is ~200 V/m at 1 KHz. Our electric field measurement technology combining optical fiber interference with gold nanostructures shows the advantages of security, high sensitivity, compact size, and multiplexed multi-point and remote detection. PMID:26507680

  16. Direct comparison between satellite electric field measurements and the visual aurora

    NASA Technical Reports Server (NTRS)

    Swift, D. W.; Gurnett, D. A.

    1973-01-01

    Electric field data from two passes of the Injun 5 satellite, one corresponding to magnetically quiet conditions and one corresponding to substorm conditions, are compared with simultaneous all-sky-camera data from College, Alaska. In each case, a significant deviation of the electric field from the expected V x B field (where V is the satellite velocity) was evident and a distinct electric field reversal could be identified. In the region of substantial electric field equatorward of the electric field reversal a diffuse auroral arc was observed during the magnetically quiet pass and auroral patches were observed during the substorm pass. The motion of the auroral patches was consistent with the general direction and magnitude of the E x B drift computed from the satellite electric field measurements. In the substorm case the electric field reversal occurred very near a discrete auroral arc at the poleward side of the diffuse arcs and patches. Comparison of the quiet time and substorm cases suggests that the convection electric field penetrates deeper into the magnetosphere during a substorm.

  17. Inhibition of brain tumor cell proliferation by alternating electric fields

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jeong, Hyesun; Oh, Seung-ick; Hong, Sunghoi, E-mail: shong21@korea.ac.kr, E-mail: radioyoon@korea.ac.kr

    2014-11-17

    This study was designed to investigate the mechanism by which electric fields affect cell function, and to determine the optimal conditions for electric field inhibition of cancer cell proliferation. Low-intensity (<2 V/cm) and intermediate-frequency (100–300 kHz) alternating electric fields were applied to glioblastoma cell lines. These electric fields inhibited cell proliferation by inducing cell cycle arrest and abnormal mitosis due to the malformation of microtubules. These effects were significantly dependent on the intensity and frequency of applied electric fields.

  18. A corotation electric field model of the Earth derived from Swarm satellite magnetic field measurements

    NASA Astrophysics Data System (ADS)

    Maus, Stefan

    2017-08-01

    Rotation of the Earth in its own geomagnetic field sets up a primary corotation electric field, compensated by a secondary electric field of induced electrical charges. For the geomagnetic field measured by the Swarm constellation of satellites, a derivation of the global corotation electric field inside and outside of the corotation region is provided here, in both inertial and corotating reference frames. The Earth is assumed an electrical conductor, the lower atmosphere an insulator, followed by the corotating ionospheric E region again as a conductor. Outside of the Earth's core, the induced charge is immediately accessible from the spherical harmonic Gauss coefficients of the geomagnetic field. The charge density is positive at high northern and southern latitudes, negative at midlatitudes, and increases strongly toward the Earth's center. Small vertical electric fields of about 0.3 mV/m in the insulating atmospheric gap are caused by the corotation charges located in the ionosphere above and the Earth below. The corotation charges also flow outward into the region of closed magnetic field lines, forcing the plasmasphere to corotate. The electric field of the corotation charges further extends outside of the corotating regions, contributing radial outward electric fields of about 10 mV/m in the northern and southern polar caps. Depending on how the magnetosphere responds to these fields, the Earth may carry a net electric charge.

  19. Rotation Detection Using the Precession of Molecular Electric Dipole Moment

    NASA Astrophysics Data System (ADS)

    Ke, Yi; Deng, Xiao-Bing; Hu, Zhong-Kun

    2017-11-01

    We present a method to detect the rotation by using the precession of molecular electric dipole moment in a static electric field. The molecular electric dipole moments are polarized under the static electric field and a nonzero electric polarization vector emerges in the molecular gas. A resonant radio-frequency pulse electric field is applied to realize a 90° flip of the electric polarization vector of a particular rotational state. After the pulse electric field, the electric polarization vector precesses under the static electric field. The rotation induces a shift in the precession frequency which is measured to deduce the angular velocity of the rotation. The fundamental sensitivity limit of this method is estimated. This work is only a proposal and does not involve experimental results.

  20. The effect of pulsed electric fields on carotenoids bioaccessibility: The role of tomato matrix.

    PubMed

    Bot, Francesca; Verkerk, Ruud; Mastwijk, Hennie; Anese, Monica; Fogliano, Vincenzo; Capuano, Edoardo

    2018-02-01

    Tomato fractions were subjected to pulsed electric fields treatment combined or not with heating. Results showed that pulsed electric fields and heating applied in combination or individually induced permeabilization of cell membranes in the tomato fractions. However, no changes in β-carotene and lycopene bioaccessibility were found upon combined and individual pulsed electric fields and heating, except in the following cases: (i) in tissue, a significant decrease in lycopene bioaccessibility upon combined pulsed electric fields and heating and heating only was observed; (ii) in chromoplasts, both β-carotene and lycopene bioaccessibility significantly decreased upon combined pulsed electric fields and heating and pulsed electric fields only. The reduction in carotenoids bioaccessibility was attributed to modification in chromoplasts membrane and carotenoids-protein complexes. Differences in the effects of pulsed electric fields on bioaccessibility among different tomato fractions were related to tomato structure complexity. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Health consequences of electric lighting practices in the modern world: A report on the National Toxicology Program's workshop on shift work at night, artificial light at night, and circadian disruption.

    PubMed

    Lunn, Ruth M; Blask, David E; Coogan, Andrew N; Figueiro, Mariana G; Gorman, Michael R; Hall, Janet E; Hansen, Johnni; Nelson, Randy J; Panda, Satchidananda; Smolensky, Michael H; Stevens, Richard G; Turek, Fred W; Vermeulen, Roel; Carreón, Tania; Caruso, Claire C; Lawson, Christina C; Thayer, Kristina A; Twery, Michael J; Ewens, Andrew D; Garner, Sanford C; Schwingl, Pamela J; Boyd, Windy A

    2017-12-31

    The invention of electric light has facilitated a society in which people work, sleep, eat, and play at all hours of the 24-hour day. Although electric light clearly has benefited humankind, exposures to electric light, especially light at night (LAN), may disrupt sleep and biological processes controlled by endogenous circadian clocks, potentially resulting in adverse health outcomes. Many of the studies evaluating adverse health effects have been conducted among night- and rotating-shift workers, because this scenario gives rise to significant exposure to LAN. Because of the complexity of this topic, the National Toxicology Program convened an expert panel at a public workshop entitled "Shift Work at Night, Artificial Light at Night, and Circadian Disruption" to obtain input on conducting literature-based health hazard assessments and to identify data gaps and research needs. The Panel suggested describing light both as a direct effector of endogenous circadian clocks and rhythms and as an enabler of additional activities or behaviors that may lead to circadian disruption, such as night-shift work and atypical and inconsistent sleep-wake patterns that can lead to social jet lag. Future studies should more comprehensively characterize and measure the relevant light-related exposures and link these exposures to both time-independent biomarkers of circadian disruption and biomarkers of adverse health outcomes. This information should lead to improvements in human epidemiological and animal or in vitro models, more rigorous health hazard assessments, and intervention strategies to minimize the occurrence of adverse health outcomes due to these exposures. Published by Elsevier B.V.

  2. Reception and learning of electric fields in bees

    PubMed Central

    Greggers, Uwe; Koch, Gesche; Schmidt, Viola; Dürr, Aron; Floriou-Servou, Amalia; Piepenbrock, David; Göpfert, Martin C.; Menzel, Randolf

    2013-01-01

    Honeybees, like other insects, accumulate electric charge in flight, and when their body parts are moved or rubbed together. We report that bees emit constant and modulated electric fields when flying, landing, walking and during the waggle dance. The electric fields emitted by dancing bees consist of low- and high-frequency components. Both components induce passive antennal movements in stationary bees according to Coulomb's law. Bees learn both the constant and the modulated electric field components in the context of appetitive proboscis extension response conditioning. Using this paradigm, we identify mechanoreceptors in both joints of the antennae as sensors. Other mechanoreceptors on the bee body are potentially involved but are less sensitive. Using laser vibrometry, we show that the electrically charged flagellum is moved by constant and modulated electric fields and more strongly so if sound and electric fields interact. Recordings from axons of the Johnston organ document its sensitivity to electric field stimuli. Our analyses identify electric fields emanating from the surface charge of bees as stimuli for mechanoreceptors, and as biologically relevant stimuli, which may play a role in social communication. PMID:23536603

  3. Reception and learning of electric fields in bees.

    PubMed

    Greggers, Uwe; Koch, Gesche; Schmidt, Viola; Dürr, Aron; Floriou-Servou, Amalia; Piepenbrock, David; Göpfert, Martin C; Menzel, Randolf

    2013-05-22

    Honeybees, like other insects, accumulate electric charge in flight, and when their body parts are moved or rubbed together. We report that bees emit constant and modulated electric fields when flying, landing, walking and during the waggle dance. The electric fields emitted by dancing bees consist of low- and high-frequency components. Both components induce passive antennal movements in stationary bees according to Coulomb's law. Bees learn both the constant and the modulated electric field components in the context of appetitive proboscis extension response conditioning. Using this paradigm, we identify mechanoreceptors in both joints of the antennae as sensors. Other mechanoreceptors on the bee body are potentially involved but are less sensitive. Using laser vibrometry, we show that the electrically charged flagellum is moved by constant and modulated electric fields and more strongly so if sound and electric fields interact. Recordings from axons of the Johnston organ document its sensitivity to electric field stimuli. Our analyses identify electric fields emanating from the surface charge of bees as stimuli for mechanoreceptors, and as biologically relevant stimuli, which may play a role in social communication.

  4. Exogenous and endogenous attention during perceptual learning differentially affect post-training target thresholds

    PubMed Central

    Mukai, Ikuko; Bahadur, Kandy; Kesavabhotla, Kartik; Ungerleider, Leslie G.

    2012-01-01

    There is conflicting evidence in the literature regarding the role played by attention in perceptual learning. To further examine this issue, we independently manipulated exogenous and endogenous attention and measured the rate of perceptual learning of oriented Gabor patches presented in different quadrants of the visual field. In this way, we could track learning at attended, divided-attended, and unattended locations. We also measured contrast thresholds of the Gabor patches before and after training. Our results showed that, for both exogenous and endogenous attention, accuracy in performing the orientation discrimination improved to a greater extent at attended than at unattended locations. Importantly, however, only exogenous attention resulted in improved contrast thresholds. These findings suggest that both exogenous and endogenous attention facilitate perceptual learning, but that these two types of attention may be mediated by different neural mechanisms. PMID:21282340

  5. Electric Field Imaging Project

    NASA Technical Reports Server (NTRS)

    Wilcutt, Terrence; Hughitt, Brian; Burke, Eric; Generazio, Edward

    2016-01-01

    NDE historically has focused technology development in propagating wave phenomena with little attention to the field of electrostatics and emanating electric fields. This work is intended to bring electrostatic imaging to the forefront of new inspection technologies, and new technologies in general. The specific goals are to specify the electric potential and electric field including the electric field spatial components emanating from, to, and throughout volumes containing objects or in free space.

  6. Electric-field enhanced performance in catalysis and solid-state devices involving gases

    DOEpatents

    Blackburn, Bryan M.; Wachsman, Eric D.; Van Assche, IV, Frederick Martin

    2015-05-19

    Electrode configurations for electric-field enhanced performance in catalysis and solid-state devices involving gases are provided. According to an embodiment, electric-field electrodes can be incorporated in devices such as gas sensors and fuel cells to shape an electric field provided with respect to sensing electrodes for the gas sensors and surfaces of the fuel cells. The shaped electric fields can alter surface dynamics, system thermodynamics, reaction kinetics, and adsorption/desorption processes. In one embodiment, ring-shaped electric-field electrodes can be provided around sensing electrodes of a planar gas sensor.

  7. Effect of strong electric field on the conformational integrity of insulin.

    PubMed

    Wang, Xianwei; Li, Yongxiu; He, Xiao; Chen, Shude; Zhang, John Z H

    2014-10-02

    A series of molecular dynamics (MD) simulations up to 1 μs for bovine insulin monomer in different external electric fields were carried out to study the effect of external electric field on conformational integrity of insulin. Our results show that the secondary structure of insulin is kept intact under the external electric field strength below 0.15 V/nm, but disruption of secondary structure is observed at 0.25 V/nm or higher electric field strength. Although the starting time of secondary structure disruption of insulin is not clearly correlated with the strength of the external electric field ranging between 0.15 and 0.60 V/nm, long time MD simulations demonstrate that the cumulative effect of exposure time under the electric field is a major cause for the damage of insulin's secondary structure. In addition, the strength of the external electric field has a significant impact on the lifetime of hydrogen bonds when it is higher than 0.60 V/nm. The fast evolution of some hydrogen bonds of bovine insulin in the presence of the 1.0 V/nm electric field shows that different microwaves could either speed up protein folding or destroy the secondary structure of globular proteins deponding on the intensity of the external electric field.

  8. Electron transport in reduced graphene oxides in high electric field

    NASA Astrophysics Data System (ADS)

    Jian, Wen-Bin; Lai, Jian-Jhong; Wang, Sheng-Tsung; Tsao, Rui-Wen; Su, Min-Chia; Tsai, Wei-Yu; Rosenstein, Baruch; Zhou, Xufeng; Liu, Zhaoping

    Due to a honeycomb structure, charge carriers in graphene exhibit quasiparticles of linear energy-momentum dispersion and phenomena of Schwinger pair creation may be explored. Because graphene is easily broken in high electric fields, single-layer reduced graphene oxides (rGO) are used instead. The rGO shows a small band gap while it reveals a graphene like behavior in high electric fields. Electron transport in rGO exhibits two-dimensional Mott's variable range hopping. The temperature behavior of resistance in low electric fields and the electric field behavior of resistance at low temperatures are all well explained by the Mott model. At temperatures higher than 200 K, the electric field behavior does not agree with the model while it shows a power law behavior with an exponent of 3/2, being in agreement with the Schwinger model. Comparing with graphene, the rGO is more sustainable to high electric field thus presenting a complete high-electric field behavior. When the rGO is gated away from the charge neutral point, the turn-on electric field of Schwinger phenomena is increased. A summary figure is given to present electric field behaviors and power law variations of resistances of single-layer rGO, graphene, and MoS2.

  9. Endogenous opiates and behavior: 2005.

    PubMed

    Bodnar, Richard J; Klein, Gad E

    2006-12-01

    This paper is the 28th consecutive installment of the annual review of research concerning the endogenous opioid system, now spanning over a quarter-century of research. It summarizes papers published during 2005 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior (Section 2), and the roles of these opioid peptides and receptors in pain and analgesia (Section 3); stress and social status (Section 4); tolerance and dependence (Section 5); learning and memory (Section 6); eating and drinking (Section 7); alcohol and drugs of abuse (Section 8); sexual activity and hormones, pregnancy, development and endocrinology (Section 9); mental illness and mood (Section 10); seizures and neurologic disorders (Section 11); electrical-related activity, neurophysiology and transmitter release (Section 12); general activity and locomotion (Section 13); gastrointestinal, renal and hepatic functions (Section 14); cardiovascular responses (Section 15); respiration and thermoregulation (Section 16); immunological responses (Section 17).

  10. Endogenous opiates and behavior: 2010.

    PubMed

    Bodnar, Richard J

    2011-12-01

    This paper is the thirty-third consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2010 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior (Section 2), and the roles of these opioid peptides and receptors in pain and analgesia (Section 3); stress and social status (Section 4); tolerance and dependence (Section 5); learning and memory (Section 6); eating and drinking (Section 7); alcohol and drugs of abuse (Section 8); sexual activity and hormones, pregnancy, development and endocrinology (Section 9); mental illness and mood (Section 10); seizures and neurologic disorders (Section 11); electrical-related activity and neurophysiology (Section 12); general activity and locomotion (Section 13); gastrointestinal, renal and hepatic functions (Section 14); cardiovascular responses (Section 15); respiration (Section 16); and immunological responses (Section 17). Copyright © 2011 Elsevier Inc. All rights reserved.

  11. Endogenous opiates and behavior: 2002.

    PubMed

    Bodnar, Richard J; Hadjimarkou, Maria M

    2003-08-01

    This paper is the twenty-fifth consecutive installment of the annual review of research concerning the endogenous opioid system, now spanning over a quarter-century of research. It summarizes papers published during 2002 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior (Section 2), and the roles of these opioid peptides and receptors in pain and analgesia (Section 3); stress and social status (Section 4); tolerance and dependence (Section 5); learning and memory (Section 6); eating and drinking (Section 7); alcohol and drugs of abuse (Section 8); sexual activity and hormones, pregnancy, development and endocrinology (Section 9); mental illness and mood (Section 10); seizures and neurologic disorders (Section 11); electrical-related activity and neurophysiology (Section 12); general activity and locomotion (Section 13); gastrointestinal, renal and hepatic functions (Section 14); cardiovascular responses (Section 15); respiration and thermoregulation (Section 16); and immunological responses (Section 17).

  12. Endogenous opiates and behavior: 2006.

    PubMed

    Bodnar, Richard J

    2007-12-01

    This paper is the 29th consecutive installment of the annual review of research concerning the endogenous opioid system, now spanning 30 years of research. It summarizes papers published during 2006 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior (Section 2), and the roles of these opioid peptides and receptors in pain and analgesia (Section 3); stress and social status (Section 4); tolerance and dependence (Section 5); learning and memory (Section 6); eating and drinking (Section 7); alcohol and drugs of abuse (Section 8); sexual activity and hormones, pregnancy, development and endocrinology (Section 9); mental illness and mood (Section 10); seizures and neurological disorders (Section 11); electrical-related activity and neurophysiology (Section 12); general activity and locomotion (Section 13); gastrointestinal, renal and hepatic functions (Section 14); cardiovascular responses (Section 15); respiration and thermoregulation (Section 16); and immunological responses (Section 17).

  13. Endogenous opiates and behavior: 2009.

    PubMed

    Bodnar, Richard J

    2010-12-01

    This paper is the 32nd consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2009 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior (Section 2), and the roles of these opioid peptides and receptors in pain and analgesia (Section 3); stress and social status (Section 4); tolerance and dependence (Section 5); learning and memory (Section 6); eating and drinking (Section 7); alcohol and drugs of abuse (Section 8); sexual activity and hormones, pregnancy, development and endocrinology (Section 9); mental illness and mood (Section 10); seizures and neurologic disorders (Section 11); electrical-related activity and neurophysiology (Section 12); general activity and locomotion (Section 13); gastrointestinal, renal and hepatic functions (Section 14); cardiovascular responses (Section 15); respiration and thermoregulation (Section 16); and immunological responses (Section 17). Copyright © 2010 Elsevier Inc. All rights reserved.

  14. Endogenous opiates and behavior: 2011.

    PubMed

    Bodnar, Richard J

    2012-12-01

    This paper is the thirty-fourth consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2011 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior (Section 2), and the roles of these opioid peptides and receptors in pain and analgesia (Section 3); stress and social status (Section 4); tolerance and dependence (Section 5); learning and memory (Section 6); eating and drinking (Section 7); alcohol and drugs of abuse (Section 8); sexual activity and hormones, pregnancy, development and endocrinology (Section 9); mental illness and mood (Section 10); seizures and neurologic disorders (Section 11); electrical-related activity and neurophysiology (Section 12); general activity and locomotion (Section 13); gastrointestinal, renal and hepatic functions (Section 14); cardiovascular responses (Section 15); respiration (Section 16); and immunological responses (Section 17). Copyright © 2012 Elsevier Inc. All rights reserved.

  15. Endogenous opiates and behavior: 2003.

    PubMed

    Bodnar, Richard J; Klein, Gad E

    2004-12-01

    This paper is the 26th consecutive installment of the annual review of research concerning the endogenous opioid system, now spanning over a quarter-century of research. It summarizes papers published during 2003 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior (Section 2), and the roles of these opioid peptides and receptors in pain and analgesia (Section 3); stress and social status (Section 4); tolerance and dependence (Section 5); learning and memory (Section 6); eating and drinking (Section 7); alcohol and drugs of abuse (Section 8); sexual activity and hormones, pregnancy, development and endocrinology (Section 9); mental illness and mood (Section 10); seizures and neurologic disorders (Section 11); electrical-related activity and neurophysiology (Section 12); general activity and locomotion (Section 13); gastrointestinal, renal and hepatic functions (Section 14); cardiovascular responses (Section 15); respiration and thermoregulation (Section 16); and immunological responses (Section 17).

  16. Endogenous Opiates and Behavior: 2006

    PubMed Central

    Bodnar, Richard J.

    2009-01-01

    This paper is the twenty-ninth consecutive installment of the annual review of research concerning the endogenous opioid system, now spanning thirty years of research. It summarizes papers published during 2006 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior (Section 2), and the roles of these opioid peptides and receptors in pain and analgesia (Section 3); stress and social status (Section 4); tolerance and dependence (Section 5); learning and memory (Section 6); eating and drinking (Section 7); alcohol and drugs of abuse (Section 8); sexual activity and hormones, pregnancy, development and endocrinology (Section 9); mental illness and mood (Section 10); seizures and neurological disorders (Section 11); electrical-related activity and neurophysiology (Section 12); general activity and locomotion (Section 13); gastrointestinal, renal and hepatic functions (Section 14); cardiovascular responses (Section 15); respiration and thermoregulation (Section 16); and immunological responses (Section 17). PMID:17949854

  17. Endogenous opiates and behavior: 2012.

    PubMed

    Bodnar, Richard J

    2013-12-01

    This paper is the thirty-fifth consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2012 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior (Section 2), and the roles of these opioid peptides and receptors in pain and analgesia (Section 3); stress and social status (Section 4); tolerance and dependence (Section 5); learning and memory (Section 6); eating and drinking (Section 7); alcohol and drugs of abuse (Section 8); sexual activity and hormones, pregnancy, development and endocrinology (Section 9); mental illness and mood (Section 10); seizures and neurologic disorders (Section 11); electrical-related activity and neurophysiology (Section 12); general activity and locomotion (Section 13); gastrointestinal, renal and hepatic functions (Section 14); cardiovascular responses (Section 15); respiration and thermoregulation (Section 16); and immunological responses (Section 17). Copyright © 2013 Elsevier Inc. All rights reserved.

  18. Electric-field-driven switching of individual magnetic skyrmions

    NASA Astrophysics Data System (ADS)

    Hsu, Pin-Jui; Kubetzka, André; Finco, Aurore; Romming, Niklas; von Bergmann, Kirsten; Wiesendanger, Roland

    2017-02-01

    Controlling magnetism with electric fields is a key challenge to develop future energy-efficient devices. The present magnetic information technology is mainly based on writing processes requiring either local magnetic fields or spin torques, but it has also been demonstrated that magnetic properties can be altered on the application of electric fields. This has been ascribed to changes in magnetocrystalline anisotropy caused by spin-dependent screening and modifications of the band structure, changes in atom positions or differences in hybridization with an adjacent oxide layer. However, the switching between states related by time reversal, for example magnetization up and down as used in the present technology, is not straightforward because the electric field does not break time-reversal symmetry. Several workarounds have been applied to toggle between bistable magnetic states with electric fields, including changes of material composition as a result of electric fields. Here we demonstrate that local electric fields can be used to switch reversibly between a magnetic skyrmion and the ferromagnetic state. These two states are topologically inequivalent, and we find that the direction of the electric field directly determines the final state. This observation establishes the possibility to combine electric-field writing with the recently envisaged skyrmion racetrack-type memories.

  19. Questions Students Ask: Why Not Bend Light with an Electric Field?

    ERIC Educational Resources Information Center

    Van Heuvelen, Alan

    1983-01-01

    In response to a question, "Why not use a magnetic or electric field to deflect light?," reviews the relation between electric charge and electric/magnetic fields. Discusses the Faraday effect, (describing matter as an intermediary in the rotation of the place of polarization) and other apparent interactions of light with electric/magnetic fields.…

  20. Assessing human exposure to power-frequency electric and magnetic fields.

    PubMed Central

    Kaune, W T

    1993-01-01

    This paper reviews published literature and current problems relating to the assessment of occupational and residential human exposures to power-frequency electric and magnetic fields. Available occupational exposure data suggest that the class of job titles known as electrical workers may be an effective surrogate for time-weighted-average (TWA) magnetic-field (but not electric-field) exposure. Current research in occupational-exposure assessment is directed to the construction of job-exposure matrices based on electric- and magnetic-field measurements and estimates of worker exposures to chemicals and other factors of interest. Recent work has identified five principal sources of residential magnetic fields: electric power transmission lines, electric power distribution lines, ground currents, home wiring, and home appliances. Existing residential-exposure assessments have used one or more of the following techniques: questionnaires, wiring configuration coding, theoretical field calculations, spot electric- and magnetic-field measurements, fixed-site magnetic-field recordings, personal- exposure measurements, and geomagnetic-field measurements. Available normal-power magnetic-field data for residences differ substantially between studies. It is not known if these differences are due to geographical differences, differences in measurement protocols, or instrumentation differences. Wiring codes and measured magnetic fields (but not electric fields) are associated weakly. Available data suggest, but are far from proving, that spot measurements may be more effective than wire codes as predictors of long-term historical magnetic-field exposure. Two studies find that away-from-home TWA magnetic-field exposures are less variable than at-home exposures. The importance of home appliances as contributors to total residential magnetic-field exposure is not known at this time. It also is not known what characteristics (if any) of residential electric and magnetic fields are determinants of human health effects. PMID:8206021

  1. Remote sensing of mesospheric electric fields using MF radars

    NASA Astrophysics Data System (ADS)

    Meek, C. E.; Manson, A. H.; Martynenko, S. I.; Rozumenko, V. T.; Tyrnov, O. F.

    2004-07-01

    Large mesospheric electric fields can play an essential role in middle atmospheric electrodynamics (see, e.g., Goldberg, R. A., Middle Atmospheric Electrodynamics during MAP, Adv. Space Res. 10 (10) (1990) 209). The V/m electric fields of atmospheric origin can be the possible cause of large variations in the electron collision frequency at mesospheric altitudes, and this provides a unique opportunity to take measurements of electric fields in the lower ionosphere by using remote sensing instruments employing radiowave techniques. A technique has been proposed for making estimates of large mesospheric electric field intensities on the lower edge of the ionosphere by using MF radar data and the inherent effective electron collision frequency. To do this, data collected in Canada and Ukraine were utilized. The developed technique permits the changes in mesospheric electric field intensities to be derived from MF radar data in real time. The statistical analysis of data consistent with large mesospheric electric field intensities in the 60-67km region resulted in the following inferences. There are at least two mechanisms for the generation of large mesospheric electric fields in the mesosphere. The most likely mechanism, with a probability of 60-70%, is the summation of random fields from a large number of elementary small-scale mesospheric generators, which results in a one-parameter Rayleigh distribution of the total large mesospheric electric field intensity E with a mean value of approximately 0.7-0.9V/m in the 60-67km altitude region, or in the corresponding one-parameter exponential distribution of the intensity squared E2 of large mesospheric electric fields. The second mechanism of unknown nature, with 5-15% probability, gives rise to the sporadic appearance of large mesospheric electric field intensities E>2.5V/m with a mean of 4V/m. Statistically significant seasonal differences in the averaged large mesospheric electric field parameters have not been revealed. The probability of the absence of local large mesospheric electric fields amounts to approximately 25% for Ukraine and approximately 30% for Canada. A comparison of the Ukrainian and Canadian data indicates the possible existence of a latitudinal dependence in mean large mesospheric electric field features. Hence, the large electric fields are an additional source of electron heating that must be taken into account in studying a disturbed lower ionosphere and radio wave propagation within it.

  2. High electric field conduction in low-alkali boroaluminosilicate glass

    NASA Astrophysics Data System (ADS)

    Dash, Priyanka; Yuan, Mengxue; Gao, Jun; Furman, Eugene; Lanagan, Michael T.

    2018-02-01

    Electrical conduction in silica-based glasses under a low electric field is dominated by high mobility ions such as sodium, and there is a transition from ionic transport to electronic transport as the electric field exceeds 108 V/m at low temperatures. Electrical conduction under a high electric field was investigated in thin low-alkali boroaluminosilicate glass samples, showing nonlinear conduction with the current density scaling approximately with E1/2, where E is the electric field. In addition, thermally stimulated depolarization current (TSDC) characterization was carried out on room-temperature electrically poled glass samples, and an anomalous discharging current flowing in the same direction as the charging current was observed. High electric field conduction and TSDC results led to the conclusion that Poole-Frenkel based electronic transport occurs in the mobile-cation-depleted region adjacent to the anode, and accounts for the observed anomalous current.

  3. Electric emissions from electrical appliances.

    PubMed

    Leitgeb, N; Cech, R; Schröttner, J

    2008-01-01

    Electric emissions from electric appliances are frequently considered negligible, and standards consider electric appliances to comply without testing. By investigating 122 household devices of 63 different categories, it could be shown that emitted electric field levels do not justify general disregard. Electric reference values can be exceeded up to 11-fold. By numerical dosimetry with homogeneous human models, induced intracorporal electric current densities were determined and factors calculated to elevate reference levels to accounting for reduced induction efficiency of inhomogeneous fields. These factors were found not high enough to allow generally concluding on compliance with basic restrictions without testing. Electric appliances usually simultaneously emit both electric and magnetic fields exposing almost the same body region. Since the sum of induced current densities is limited, one field component reduces the available margin for the other. Therefore, superposition of electric current densities induced by either field would merit consideration.

  4. Neuropeptide Y is a prejunctional inhibitor of vagal but not sympathetic inotropic responses in guinea-pig isolated left atria

    PubMed Central

    Serone, Adrian P; Angus, James A

    1999-01-01

    The effects of NPY and related peptides were examined on basal contractile force and nerve-mediated inotropic responses to electrical field stimulation of the guinea-pig isolated left atrium.Electrical field stimulus (EFS)-inotropic response curves were constructed by applying 1-64 trains of four field pulses (200 Hz, 0.1 ms duration, 100 V) across isolated left atria (paced at 4 Hz, 2 ms, 1–4 V) within the atrial refractory period. Curves were constructed in presence of vehicle, propranolol (1 μM) or atropine (1 μM) to determine appropriate stimulus conditions.The effects of PYY (1–10,000 nM), NPY (0.01–10 μM), N-Ac-[Leu28,31]NPY(24–36) (N-A[L]NPY(24–36); 0.01–10 μM) and clonidine (0.1–1000 nM) were examined on the positive and negative inotropic responses to EFS (eight trains, four pulses per refractory period).NPY-related peptides had no effect on basal force of contraction nor on the inotropic concentration-response curves to bethanechol or isoprenaline. All three peptides inhibited vagally-mediated negative inotropic responses; rank order of potency PYY>NPY⩾N-A[L]NPY(24–36) was consistent with an action at prejunctional Y2-receptors. Clonidine concentration-dependently inhibited sympathetic inotropic responses. However, PYY, NPY and N-A[L]NPY(24–36) failed to mediate any significant inhibition of the positive inotropic response to EFS.These data demonstrate that NPY is an effective inhibitor of vagal but not sympathetically-mediated inotropic responses in the guinea-pig isolated left atria. This may suggest that endogenously co-released NPY is important in mediating cross talk between efferent components of the autonomic nervous system modulating cardiac contractility, acting overall to sustain positive inotropic responses. PMID:10385237

  5. Electric Potential and Electric Field Imaging with Applications

    NASA Technical Reports Server (NTRS)

    Generazio, Ed

    2016-01-01

    The technology and techniques for remote quantitative imaging of electrostatic potentials and electrostatic fields in and around objects and in free space is presented. Electric field imaging (EFI) technology may be applied to characterize intrinsic or existing electric potentials and electric fields, or an externally generated electrostatic field may be used for (illuminating) volumes to be inspected with EFI. The baseline sensor technology, electric field sensor (e-sensor), and its construction, optional electric field generation (quasistatic generator), and current e-sensor enhancements (ephemeral e-sensor) are discussed. Demonstrations for structural, electronic, human, and memory applications are shown. This new EFI capability is demonstrated to reveal characterization of electric charge distribution, creating a new field of study that embraces areas of interest including electrostatic discharge mitigation, crime scene forensics, design and materials selection for advanced sensors, dielectric morphology of structures, inspection of containers, inspection for hidden objects, tether integrity, organic molecular memory, and medical diagnostic and treatment efficacy applications such as cardiac polarization wave propagation and electromyography imaging.

  6. Effects of an electric field on interaction of aromatic systems.

    PubMed

    Youn, Il Seung; Cho, Woo Jong; Kim, Kwang S

    2016-04-30

    The effect of uniform external electric field on the interactions between small aromatic compounds and an argon atom is investigated using post-HF (MP2, SCS-MP2, and CCSD(T)) and density functional (PBE0-D3, PBE0-TS, and vdW-DF2) methods. The electric field effect is quantified by the difference of interaction energy calculated in the presence and absence of the electric field. All the post-HF methods describe electric field effects accurately although the interaction energy itself is overestimated by MP2. The electric field effect is explained by classical electrostatic models, where the permanent dipole moment from mutual polarization mainly determines its sign. The size of π-conjugated system does not have significant effect on the electric field dependence. We found out that PBE0-based methods give reasonable interaction energies and electric field response in every case, while vdW-DF2 sometimes shows spurious artifact owing to its sensitivity toward the real space electron density. © 2015 Wiley Periodicals, Inc.

  7. Lattice QCD with strong external electric fields.

    PubMed

    Yamamoto, Arata

    2013-03-15

    We study particle generation by a strong electric field in lattice QCD. To avoid the sign problem of the Minkowskian electric field, we adopt the "isospin" electric charge. When a strong electric field is applied, the insulating vacuum is broken down and pairs of charged particles are produced by the Schwinger mechanism. The competition against the color confining force is also discussed.

  8. Divergent effect of electric fields on the mechanical property of water-filled carbon nanotubes with an application as a nanoscale trigger

    NASA Astrophysics Data System (ADS)

    Ye, Hongfei; Zheng, Yonggang; Zhou, Lili; Zhao, Junfei; Zhang, Hongwu; Chen, Zhen

    2018-01-01

    Polar water molecules exhibit extraordinary phenomena under nanoscale confinement. Through the application of an electric field, a water-filled carbon nanotube (CNT) that has been successfully fabricated in the laboratory is expected to have distinct responses to the external electricity. Here, we examine the effect of electric field direction on the mechanical property of water-filled CNTs. It is observed that a longitudinal electric field enhances, but the transverse electric field reduces the elastic modulus and critical buckling stress of water-filled CNTs. The divergent effect of the electric field is attributed to the competition between the axial and circumferential pressures induced by polar water molecules. Furthermore, it is notable that the transverse electric field could result in an internal pressure with elliptical distribution, which is an effective and convenient approach to apply nonuniform pressure on nanochannels. Based on pre-strained water-filled CNTs, we designed a nanoscale trigger with an evident and rapid height change initiated by switching the direction of the electric field. The reported finding provides a foundation for an electricity-controlled property of nanochannels filled with polar molecules and provides an insight into the design of nanoscale functional devices.

  9. Divergent effect of electric fields on the mechanical property of water-filled carbon nanotubes with an application as a nanoscale trigger.

    PubMed

    Ye, Hongfei; Zheng, Yonggang; Zhou, Lili; Zhao, Junfei; Zhang, Hongwu; Chen, Zhen

    2017-12-11

    Polar water molecules exhibit extraordinary phenomena under nanoscale confinement. Through the application of an electric field, a water-filled carbon nanotube (CNT) that has been successfully fabricated in the laboratory is expected to have distinct responses to the external electricity. Here, we examine the effect of electric field direction on the mechanical property of water-filled CNTs. It is observed that a longitudinal electric field enhances, but the transverse electric field reduces the elastic modulus and critical buckling stress of water-filled CNTs. The divergent effect of the electric field is attributed to the competition between the axial and circumferential pressures induced by polar water molecules. Furthermore, it is notable that the transverse electric field could result in an internal pressure with elliptical distribution, which is an effective and convenient approach to apply nonuniform pressure on nanochannels. Based on pre-strained water-filled CNTs, we designed a nanoscale trigger with an evident and rapid height change initiated by switching the direction of the electric field. The reported finding provides a foundation for an electricity-controlled property of nanochannels filled with polar molecules and provides an insight into the design of nanoscale functional devices.

  10. Elucidating the Role of Injury-Induced Electric Fields (EFs) in Regulating the Astrocytic Response to Injury in the Mammalian Central Nervous System

    PubMed Central

    Baer, Matthew L.; Henderson, Scott C.; Colello, Raymond J.

    2015-01-01

    Injury to the vertebrate central nervous system (CNS) induces astrocytes to change their morphology, to increase their rate of proliferation, and to display directional migration to the injury site, all to facilitate repair. These astrocytic responses to injury occur in a clear temporal sequence and, by their intensity and duration, can have both beneficial and detrimental effects on the repair of damaged CNS tissue. Studies on highly regenerative tissues in non-mammalian vertebrates have demonstrated that the intensity of direct-current extracellular electric fields (EFs) at the injury site, which are 50–100 fold greater than in uninjured tissue, represent a potent signal to drive tissue repair. In contrast, a 10-fold EF increase has been measured in many injured mammalian tissues where limited regeneration occurs. As the astrocytic response to CNS injury is crucial to the reparative outcome, we exposed purified rat cortical astrocytes to EF intensities associated with intact and injured mammalian tissues, as well as to those EF intensities measured in regenerating non-mammalian vertebrate tissues, to determine whether EFs may contribute to the astrocytic injury response. Astrocytes exposed to EF intensities associated with uninjured tissue showed little change in their cellular behavior. However, astrocytes exposed to EF intensities associated with injured tissue showed a dramatic increase in migration and proliferation. At EF intensities associated with regenerating non-mammalian vertebrate tissues, these cellular responses were even more robust and included morphological changes consistent with a regenerative phenotype. These findings suggest that endogenous EFs may be a crucial signal for regulating the astrocytic response to injury and that their manipulation may be a novel target for facilitating CNS repair. PMID:26562295

  11. Effects of epithelium removal on relaxation of airway smooth muscle induced by vasoactive intestinal peptide and electrical field stimulation.

    PubMed Central

    Farmer, S. G.; Togo, J.

    1990-01-01

    1. We have studied the effect of epithelium removal on relaxation of guinea-pig isolated tracheal smooth muscle induced by vasoactive intestinal peptide (VIP) or stimulation of non-adrenergic, non-cholinergic (NANC) inhibitory nerves. Also examined were the effects of inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE). 2. Epithelium removal produced a 3.6 +/- 0.4 fold leftward shift in the VIP concentration-response curve. The supersensitivity to VIP, following epithelium removal was abolished by phosphoramidon or thiorphan (NEP inhibitors), but unaffected by captopril (an ACE inhibitor). In intact trachea, the NEP inhibitors produced leftward shifts in the VIP curves similar to those produced by epithelium removal. 3. In contrast to responses to exogenous VIP, neurogenic NANC inhibitory responses to electrical field stimulation were affected neither by epithelial denudation nor by the peptidase inhibitors. 4. As in previous studies, epithelium removal increased tracheal sensitivity to isoprenaline. This was not altered by pretreatment with a cocktail of peptidase inhibitors. Thus, the effect of the NEP inhibitors on responses to VIP appears to be relatively specific. 5. These data indicate that exogenous VIP is a substrate for airway NEP, since inhibition of the enzyme potentiates the peptide. This is further evidence that the airway epithelium provides a source for the metabolism of mediators. 6. In guinea-pig trachea the NEP responsible for cleaving VIP may be located largely in the epithelial layer, since NEP inhibition was without effect on sensitivity to VIP in epithelium-denuded preparations. If VIP is a NANC inhibitory neurotransmitter in this tissue its degradation endogenously does not appear to involve epithelial NEP. PMID:2196967

  12. Effects of electric fields on human mesenchymal stem cell behaviour and morphology using a novel multichannel device.

    PubMed

    Banks, T A; Luckman, P S B; Frith, J E; Cooper-White, J J

    2015-06-01

    The intrinsic piezoelectric nature of collagenous-rich tissues, such as bone and cartilage, can result in the production of small, endogenous electric fields (EFs) during applied mechanical stresses. In vivo, these EFs may influence cell migration, a vital component of wound healing. As a result, the application of small external EFs to bone fractures and cutaneous wounds is actively practiced clinically. Due to the significant regenerative potential of stem cells in bone and cartilage healing, and their potential role in the observed improved healing in vivo post applied EFs, using a novel medium throughput device, we investigated the impacts of physiological and aphysiological EFs on human bone marrow-derived mesenchymal stem cells (hBM-MSCs) for up to 15 hours. The applied EFs had significant impacts on hBM-MSC morphology and migration; cells displayed varying degrees of conversion to a highly elongated phenotype dependent on the EF strength, consistent perpendicular alignment to the EF vector, and definitive cathodal migration in response to EF strengths ≥0.5 V cm(-1), with the fastest migration speeds observed at between 1.7 and 3 V cm(-1). We observed variability in hBM-MSC donor-to-donor responses and overall tolerances to applied EFs. This study thus confirms hBM-MSCs are responsive to applied EFs, and their rate of migration towards the cathode is controllable depending on the EF strength, providing new insight into the physiology of hBM-MSCs and possibly a significant opportunity for the utilisation of EFs in directed scaffold colonisation in vitro for tissue engineering applications or in vivo post implantation.

  13. Domain switching of fatigued ferroelectric thin films

    NASA Astrophysics Data System (ADS)

    Tak Lim, Yun; Yeog Son, Jong; Shin, Young-Han

    2014-05-01

    We investigate the domain wall speed of a ferroelectric PbZr0.48Ti0.52O3 (PZT) thin film using an atomic force microscope incorporated with a mercury-probe system to control the degree of electrical fatigue. The depolarization field in the PZT thin film decreases with increasing the degree of electrical fatigue. We find that the wide-range activation field previously reported in ferroelectric domains result from the change of the depolarization field caused by the electrical fatigue. Domain wall speed exhibits universal behavior to the effective electric field (defined by an applied electric field minus the depolarization field), regardless of the degree of the electrical fatigue.

  14. Heisenberg spin-1/2 XXZ chain in the presence of electric and magnetic fields

    NASA Astrophysics Data System (ADS)

    Thakur, Pradeep; Durganandini, P.

    2018-02-01

    We study the interplay of electric and magnetic order in the one-dimensional Heisenberg spin-1/2 XXZ chain with large Ising anisotropy in the presence of the Dzyaloshinskii-Moriya (DM) interaction and with longitudinal and transverse magnetic fields, interpreting the DM interaction as a coupling between the local electric polarization and an external electric field. We obtain the ground state phase diagram using the density matrix renormalization group method and compute various ground state quantities like the magnetization, staggered magnetization, electric polarization and spin correlation functions, etc. In the presence of both longitudinal and transverse magnetic fields, there are three different phases corresponding to a gapped Néel phase with antiferromagnetic (AF) order, gapped saturated phase, and a critical incommensurate gapless phase. The external electric field modifies the phase boundaries but does not lead to any new phases. Both external magnetic fields and electric fields can be used to tune between the phases. We also show that the transverse magnetic field induces a vector chiral order in the Néel phase (even in the absence of an electric field) which can be interpreted as an electric polarization in a direction parallel to the AF order.

  15. Endogenous spatial attention: evidence for intact functioning in adults with autism

    PubMed Central

    Grubb, Michael A.; Behrmann, Marlene; Egan, Ryan; Minshew, Nancy J.; Carrasco, Marisa; Heeger, David J.

    2012-01-01

    Lay Abstract Attention allows us to selectively process the vast amount of information with which we are confronted. Focusing on a certain location of the visual scene (visual spatial attention) enables the prioritization of some aspects of information while ignoring others. Rapid manipulation of the attention field (i.e., the location and spread of visual spatial attention) is a critical aspect of human cognition, and previous research on spatial attention in individuals with autism spectrum disorders (ASD) has produced inconsistent results. In a series of three experiments, we evaluated claims in the literature that individuals with ASD exhibit a deficit in voluntarily controlling the deployment and size of the spatial attention field. We measured how well participants perform a visual discrimination task (accuracy) and how quickly they do so (reaction time), with and without spatial uncertainty (i.e., the lack of predictability concerning the spatial position of the upcoming stimulus). We found that high–functioning adults with autism exhibited slower reactions times overall with spatial uncertainty, but the effects of attention on performance accuracies and reaction times were indistinguishable between individuals with autism and typically developing individuals, in all three experiments. These results provide evidence of intact endogenous spatial attention function in high–functioning adults with ASD, suggesting that atypical endogenous spatial attention cannot be a latent characteristic of autism in general. Scientific Abstract Rapid manipulation of the attention field (i.e., the location and spread of visual spatial attention) is a critical aspect of human cognition, and previous research on spatial attention in individuals with autism spectrum disorders (ASD) has produced inconsistent results. In a series of three psychophysical experiments, we evaluated claims in the literature that individuals with ASD exhibit a deficit in voluntarily controlling the deployment and size of the spatial attention field. We measured the spatial distribution of performance accuracies and reaction times to quantify the sizes and locations of the attention field, with and without spatial uncertainty (i.e., the lack of predictability concerning the spatial position of the upcoming stimulus). We found that high–functioning adults with autism exhibited slower reactions times overall with spatial uncertainty, but the effects of attention on performance accuracies and reaction times were indistinguishable between individuals with autism and typically developing individuals, in all three experiments. These results provide evidence of intact endogenous spatial attention function in high–functioning adults with ASD, suggesting that atypical endogenous attention cannot be a latent characteristic of autism in general. PMID:23427075

  16. Electric field with bipolar structure during magnetic reconnection without a guide field

    NASA Astrophysics Data System (ADS)

    Guo, Jun

    2014-05-01

    We present a study on the polarized electric field during the collisionless magnetic reconnection of antiparallel fields using two dimensional particle-in-cell simulations. The simulations demonstrate clearly that electron holes and electric field with bipolar structure are produced during magnetic reconnection without a guide field. The electric field with bipolar structure can be found near the X-line and on the separatrix and the plasma sheet boundary layer, which is consistent with the observations. These structures will elongate electron's time staying in the diffusion region. In addition, the electric fields with tripolar structures are also found in our simulation.

  17. The role of the large scale convection electric field in erosion of the plasmasphere during moderate and strong storms

    NASA Astrophysics Data System (ADS)

    Thaller, S. A.; Wygant, J. R.; Cattell, C. A.; Breneman, A. W.; Bonnell, J. W.; Kletzing, C.; De Pascuale, S.; Kurth, W. S.; Hospodarsky, G. B.; Bounds, S. R.

    2015-12-01

    The Van Allen Probes offer the first opportunity to investigate the response of the plasmasphere to the enhancement and penetration of the large scale duskward convection electric field in different magnetic local time (MLT) sectors. Using electric field measurements and estimates of the cold plasma density from the Van Allen Probes' Electric Fields and Waves (EFW) instrument, we study erosion of the plasmasphere during moderate and strong geomagnetic storms. We present the electric field and density data both on an orbit by orbit basis and synoptically, showing the behavior of the convection electric field and plasmasphere over a period of months. The data indicate that the large scale duskward electric field penetrates deep (L shell < 3) into the inner magnetosphere on both the dusk and dawn sides, but that the plasmasphere response on the dusk and dawn sides differ. In particular, significant (~2 orders of magnitude) decreases in the cold plasma density occur on the dawn side within hours of the onset of enhanced duskward electric field. In contrast, on the dusk side, the plasmapause is located at higher L shell than it is on the dawn side. In some cases, in the post-noon sector, cold plasma density enhancements accompany duskward electric field enhancements for the first orbit after the electric field enchantment, consistent with a duskside, sunward flowing, drainage plume.

  18. Correlation between dielectric property by dielectrophoretic levitation and growth activity of cells exposed to electric field.

    PubMed

    Hakoda, Masaru; Hirota, Yusuke

    2013-09-01

    The purpose of this study is to develop a system analyzing cell activity by the dielectrophoresis method. Our previous studies revealed a correlation between the growth activity and dielectric property (Re[K(ω)]) of mouse hybridoma 3-2H3 cells using dielectrophoretic levitation. Furthermore, it was clarified that the differentiation activity of many stem cells could be evaluated by the Re[K(ω)] without differentiation induction. In this paper, 3-2H3 cells exposed to an alternating current (AC) electric field or a direct current (DC) electric field were cultivated, and the influence of damage by the electric field on the growth activity of the cells was examined. To evaluate the activity of the cells by measuring the Re[K(ω)], the correlation between the growth activity and the Re[K(ω)] of the cells exposed to the electric field was examined. The relations between the cell viability, growth activity, and Re[K(ω)] in the cells exposed to the AC electric field were obtained. The growth activity of the cells exposed to the AC electric field could be evaluated by the Re[K(ω)]. Furthermore, it was found that the adverse effects of the electric field on the cell viability and the growth activity were smaller in the AC electric field than the DC electric field.

  19. Energy utilization and gluconeogenesis in isolated leech segmental ganglia: Quantitative studies on the control and cellular localization of endogenous glycogen.

    PubMed

    Pennington, A J; Pentreath, V W

    1988-01-01

    The isolated segmental ganglia of the horse leech Haemopis sanguisuga were used as a model system to study the utilization and control of glycogen stores within nervous tissue. The glycogen in the ganglia was extracted and assayed fluorimentrically and its cellular localization and turnover studied by autoradiography in conjunction with [(3)H]glucose. We measured the glycogen after various periods of electrical stimulation and after incubation with K(+), Ca(2+), ouabain and glucose. The results for each experimental ganglion were compared to a paired control ganglion and the results analysed by paired t-tests. Electrical stimulation caused sequential changes in glycogen levels: a reduction of up to 67% (5-10 min); followed by an increase of up to 124% (between 15-50 min); followed by a reduction of up to 63% (60-90 min). Values were calculated for glucose utilization (e.g. 0.53 ?mol glucose/gm wet weight/min after 90 min) and estimates derived for glucose consumption per action potential per neuron (e.g. 0.12 fmol at 90 min). Glucose (1.5-10 mM) increased the amount of glycogen (1.5 mM by 30% at 60 min) and attenuated the effects of electrical stimulation. Ouabain (1 mM) blocked the effect of 5 min electrical stimulation. Nine millimolar K(+) increased glycogen by 27% after 10 min and decreased glycogen by 34% after 60 min; 3 mM Ca(2+) had no effect after 10 or 20 min and decreased glycogen by 29% after 60 min. Other concentrations of K(+) and Ca(2+) reduced glycogen after 60 min. Autoradiographic analysis demonstrated that the effects of elevated K(+) were principally within the glial cells. We conclude that (i) the glycogen stores in the glial cells of leech segmental ganglia provide an endogenous energy source which can support sustained neuronal activity, (ii) both electrical stimulation and elevated K(+) can induce gluconeogenesis within the ganglia, (iii) that electrical activation of neurons produces changes in the glycogen in the glial cells which are controlled in part by changes in K(+).

  20. Dynamics analysis of extraction of manganese intensified by electric field

    NASA Astrophysics Data System (ADS)

    Ma, Wenrui; Tao, Changyuan; Li, Huizhan; Liu, Zuohua; Liu, Renlong

    2018-06-01

    In this study, a process reinforcement technology for leaching process of pyrolusite was developed. The electric field was introduced to decrease reaction temperature and improve the leaching rate of pyrolusite. The mechanisms of electric field intensifying leaching process of pyrolusite were investigated through X-ray diffraction (XRD), and Brunauer Emmett Teller (BET) in detail. The results showed that the electric field could decrease obviously the apparent activation energy of leaching process of pyrolusite. The apparent activation energy of the leaching of pyrolusite intensified by electric field was calculated to be 53.76 kJ.mol-1. In addition, the leaching efficiency of manganese was effectively increased by 10% to 20% than that without electric field under the same conditions. This was because that the electron conduit between Fe (II)/Fe (III) and pyrite was dredged effectively by electric field.

  1. Electric field prediction for a human body-electric machine system.

    PubMed

    Ioannides, Maria G; Papadopoulos, Peter J; Dimitropoulou, Eugenia

    2004-01-01

    A system consisting of an electric machine and a human body is studied and the resulting electric field is predicted. A 3-phase induction machine operating at full load is modeled considering its geometry, windings, and materials. A human model is also constructed approximating its geometry and the electric properties of tissues. Using the finite element technique the electric field distribution in the human body is determined for a distance of 1 and 5 m from the machine and its effects are studied. Particularly, electric field potential variations are determined at specific points inside the human body and for these points the electric field intensity is computed and compared to the limit values for exposure according to international standards.

  2. Rebalancing Spatial Attention: Endogenous Orienting May Partially Overcome the Left Visual Field Bias in Rapid Serial Visual Presentation.

    PubMed

    Śmigasiewicz, Kamila; Hasan, Gabriel Sami; Verleger, Rolf

    2017-01-01

    In dynamically changing environments, spatial attention is not equally distributed across the visual field. For instance, when two streams of stimuli are presented left and right, the second target (T2) is better identified in the left visual field (LVF) than in the right visual field (RVF). Recently, it has been shown that this bias is related to weaker stimulus-driven orienting of attention toward the RVF: The RVF disadvantage was reduced with salient task-irrelevant valid cues and increased with invalid cues. Here we studied if also endogenous orienting of attention may compensate for this unequal distribution of stimulus-driven attention. Explicit information was provided about the location of T1 and T2. Effectiveness of the cue manipulation was confirmed by EEG measures: decreasing alpha power before stream onset with informative cues, earlier latencies of potentials evoked by T1-preceding distractors at the right than at the left hemisphere when T1 was cued left, and decreasing T1- and T2-evoked N2pc amplitudes with informative cues. Importantly, informative cues reduced (though did not completely abolish) the LVF advantage, indicated by improved identification of right T2, and reflected by earlier N2pc latency evoked by right T2 and larger decrease in alpha power after cues indicating right T2. Overall, these results suggest that endogenously driven attention facilitates stimulus-driven orienting of attention toward the RVF, thereby partially overcoming the basic LVF bias in spatial attention.

  3. Development, Validation, and Interlaboratory Evaluation of a Quantitative Multiplexing Method To Assess Levels of Ten Endogenous Allergens in Soybean Seed and Its Application to Field Trials Spanning Three Growing Seasons.

    PubMed

    Hill, Ryan C; Oman, Trent J; Wang, Xiujuan; Shan, Guomin; Schafer, Barry; Herman, Rod A; Tobias, Rowel; Shippar, Jeff; Malayappan, Bhaskar; Sheng, Li; Xu, Austin; Bradshaw, Jason

    2017-07-12

    As part of the regulatory approval process in Europe, comparison of endogenous soybean allergen levels between genetically engineered (GE) and non-GE plants has been requested. A quantitative multiplex analytical method using tandem mass spectrometry was developed and validated to measure 10 potential soybean allergens from soybean seed. The analytical method was implemented at six laboratories to demonstrate the robustness of the method and further applied to three soybean field studies across multiple growing seasons (including 21 non-GE soybean varieties) to assess the natural variation of allergen levels. The results show environmental factors contribute more than genetic factors to the large variation in allergen abundance (2- to 50-fold between environmental replicates) as well as a large contribution of Gly m 5 and Gly m 6 to the total allergen profile, calling into question the scientific rational for measurement of endogenous allergen levels between GE and non-GE varieties in the safety assessment.

  4. Electroporation of the photosynthetic membrane: structural changes in protein and lipid-protein domains.

    PubMed Central

    Rosemberg, Y; Rotenberg, M; Korenstein, R

    1994-01-01

    A biological membrane undergoes a reversible permeability increase through structural changes in the lipid domain when exposed to high external electric fields. The present study shows the occurrence of electric field-induced changes in the conductance of the proton channel of the H(+)-ATPase as well as electric field-induced structural changes in the lipid-protein domain of photosystem (PS) II in the photosynthetic membrane. The study was carried out by analyzing the electric field-stimulated delayed luminescence (EPL), which originates from charge recombination in the protein complexes of PS I and II of photosynthetic vesicles. We established that a small fraction of the total electric field-induced conductance change was abolished by N,N'-dicyclohexylcarbodiimide (DCCD), an inhibitor of the H(+)-ATPase. This reversible electric field-induced conductance change has characteristics of a small channel and possesses a lifetime < or = 1 ms. To detect electric field-induced changes in the lipid-protein domains of PS II, we examined the effects of phospholipase A2 (PLA2) on EPL. Higher values of EPL were observed from vesicles that were exposed in the presence of PLA2 to an electroporating electric field than to a nonelectroporating electric field. The effect of the electroporating field was a long-lived one, lasting for a period > or = 2 min. This effect was attributed to long-lived electric field-induced structural changes in the lipid-protein domains of PS II. PMID:7811916

  5. Structured DC Electric Fields With and Without Associated Plasma Density Gradients Observed with the C/NOFS Satellite

    NASA Technical Reports Server (NTRS)

    Pfaff, R.; Rowland, D.; Klenzing, J.; Freudenreich, H.; Bromund, K.; Liebrecht, C.; Roddy, P.; Hunton, D.

    2009-01-01

    DC electric field observations and associated plasma drifts gathered with the Vector Electric Field Investigation on the Air Force Communication/Navigation Outage Forecasting System (C/NOFS) satellite typically reveal considerable variation at large scales (approximately 100's of km), in both daytime and nighttime cases, with enhanced structures usually confined to the nightside. Although such electric field structures are typically associated with plasma density depletions and structures, as observed by the Planar Langmuir Probe on C/NOFS, what is surprising is the number of cases in which large amplitude, structured DC electric fields are observed without a significant plasma density counterpart structure, including their appearance at times when the ambient plasma density appears relatively quiescent. We investigate the relationship of such structured DC electric fields and the ambient plasma density in the C/NOFS satellite measurements observed thus far, taking into account both plasma density depletions and enhancements. We investigate the mapping of the electric fields along magnetic field lines from distant altitudes and latitudes to locations where the density structures, which presumably formed the original seat of the electric fields, are no longer discernible in the observations. In some cases, the electric field structures and spectral characteristics appear to mimic those associated with equatorial spread-F processes, providing important clues to their origins. We examine altitude, seasonal, and longitudinal effects in an effort to establish the origin of such structured DC electric fields observed both with, and without, associated plasma density gradients

  6. A vector-free ECG interpretation with P, QRS & T waves as unbalanced transitions between stable configurations of the heart electric field during P-R, S-T & T-P segments

    PubMed Central

    2014-01-01

    Since cell membranes are weak sources of electrostatic fields, this ECG interpretation relies on the analogy between cells and electrets. It is here assumed that cell-bound electric fields unite, reach the body surface and the surrounding space and form the thoracic electric field that consists from two concentric structures: the thoracic wall and the heart. If ECG leads measure differences in electric potentials between skin electrodes, they give scalar values that define position of the electric field center along each lead. Repolarised heart muscle acts as a stable positive electric source, while depolarized heart muscle produces much weaker negative electric field. During T-P, P-R and S-T segments electric field is stable, only subtle changes are detectable by skin electrodes. Diastolic electric field forms after ventricular depolarization (T-P segments in the ECG recording). Telediastolic electric field forms after the atria have been depolarized (P-Q segments in the ECG recording). Systolic electric field forms after the ventricular depolarization (S-T segments in the ECG recording). The three ECG waves (P, QRS and T) can then be described as unbalanced transitions of the heart electric field from one stable configuration to the next and in that process the electric field center is temporarily displaced. In the initial phase of QRS, the rapidly diminishing septal electric field makes measured potentials dependent only on positive charges of the corresponding parts of the left and the right heart that lie within the lead axes. If more positive charges are near the "DOWN" electrode than near the "UP" electrode, a Q wave will be seen, otherwise an R wave is expected. Repolarization of the ventricular muscle is dampened by the early septal muscle repolarization that reduces deflection of T waves. Since the "UP" electrode of most leads is near the usually larger left ventricle muscle, T waves are in these leads positive, although of smaller amplitude and longer duration than the QRS wave in the same lead. The proposed interpretation is applied to bundle branch blocks, fascicular (hemi-) blocks and changes during heart muscle ischemia. PMID:24506945

  7. Genomic instantiation of consciousness in neurons through a biophoton field theory.

    PubMed

    Cacha, Lleuvelyn A; Poznanski, Roman R

    2014-06-01

    A theoretical framework is developed based on the premise that brains evolved into sufficiently complex adaptive systems capable of instantiating genomic consciousness through self-awareness and complex interactions that recognize qualitatively the controlling factors of biological processes. Furthermore, our hypothesis assumes that the collective interactions in neurons yield macroergic effects, which can produce sufficiently strong electric energy fields for electronic excitations to take place on the surface of endogenous structures via alpha-helical integral proteins as electro-solitons. Specifically the process of radiative relaxation of the electro-solitons allows for the transfer of energy via interactions with deoxyribonucleic acid (DNA) molecules to induce conformational changes in DNA molecules producing an ultra weak non-thermal spontaneous emission of coherent biophotons through a quantum effect. The instantiation of coherent biophotons confined in spaces of DNA molecules guides the biophoton field to be instantaneously conducted along the axonal and neuronal arbors and in-between neurons and throughout the cerebral cortex (cortico-thalamic system) and subcortical areas (e.g., midbrain and hindbrain). Thus providing an informational character of the electric coherence of the brain - referred to as quantum coherence. The biophoton field is realized as a conscious field upon the re-absorption of biophotons by exciplex states of DNA molecules. Such quantum phenomenon brings about self-awareness and enables objectivity to have access to subjectivity in the unconscious. As such, subjective experiences can be recalled to consciousness as subjective conscious experiences or qualia through co-operative interactions between exciplex states of DNA molecules and biophotons leading to metabolic activity and energy transfer across proteins as a result of protein-ligand binding during protein-protein communication. The biophoton field as a conscious field is attributable to the resultant effect of specifying qualia from the metabolic energy field that is transported in macromolecular proteins throughout specific networks of neurons that are constantly transforming into more stable associable representations as molecular solitons. The metastability of subjective experiences based on resonant dynamics occurs when bottom-up patterns of neocortical excitatory activity are matched with top-down expectations as adaptive dynamic pressures. These dynamics of on-going activity patterns influenced by the environment and selected as the preferred subjective experience in terms of a functional field through functional interactions and biological laws are realized as subjectivity and actualized through functional integration as qualia. It is concluded that interactionism and not information processing is the key in understanding how consciousness bridges the explanatory gap between subjective experiences and their neural correlates in the transcendental brain.

  8. Bifunctional metamaterials with simultaneous and independent manipulation of thermal and electric fields.

    PubMed

    Lan, Chuwen; Bi, Ke; Fu, Xiaojian; Li, Bo; Zhou, Ji

    2016-10-03

    Metamaterials offer a powerful way to manipulate a variety of physical fields ranging from wave fields (electromagnetic field, acoustic field, elastic wave, etc.), static fields (static magnetic field, static electric field) to diffusive fields (thermal field, diffusive mass). However, the relevant reports and studies are usually limited to a single physical field or functionality. In this study, we proposed and experimentally demonstrated a bifunctional metamaterial which could manipulate thermal and electric fields simultaneously and independently. Specifically, a composite with independently controllable thermal and electric conductivity was introduced, on the basis of which a bifunctional device capable of shielding thermal flux and concentrating electric current simultaneously was designed, fabricated and characterized. This work provides an encouraging example of metamaterials transcending their natural limitations, which offers a promising future in building a broad platform for the manipulation of multi-physics fields.

  9. Surface electric fields for North America during historical geomagnetic storms

    USGS Publications Warehouse

    Wei, Lisa H.; Homeier, Nichole; Gannon, Jennifer L.

    2013-01-01

    To better understand the impact of geomagnetic disturbances on the electric grid, we recreate surface electric fields from two historical geomagnetic storms—the 1989 “Quebec” storm and the 2003 “Halloween” storms. Using the Spherical Elementary Current Systems method, we interpolate sparsely distributed magnetometer data across North America. We find good agreement between the measured and interpolated data, with larger RMS deviations at higher latitudes corresponding to larger magnetic field variations. The interpolated magnetic field data are combined with surface impedances for 25 unique physiographic regions from the United States Geological Survey and literature to estimate the horizontal, orthogonal surface electric fields in 1 min time steps. The induced horizontal electric field strongly depends on the local surface impedance, resulting in surprisingly strong electric field amplitudes along the Atlantic and Gulf Coast. The relative peak electric field amplitude of each physiographic region, normalized to the value in the Interior Plains region, varies by a factor of 2 for different input magnetic field time series. The order of peak electric field amplitudes (largest to smallest), however, does not depend much on the input. These results suggest that regions at lower magnetic latitudes with high ground resistivities are also at risk from the effect of geomagnetically induced currents. The historical electric field time series are useful for estimating the flow of the induced currents through long transmission lines to study power flow and grid stability during geomagnetic disturbances.

  10. Peripheral ionotropic glutamate receptors contribute to Fos expression increase in the spinal cord through antidromic electrical stimulation of sensory nerves.

    PubMed

    Li, Jia-Heng; He, Pei-Yao; Fan, Dan-Ni; Alemujiang, Dilinapa; Huo, Fu-Quan; Zhao, Yan; Cao, Dong-Yuan

    2018-06-21

    Previous studies have shown that peripheral ionotropic glutamate receptors are involved in the increase in sensitivity of a cutaneous branch of spinal dorsal ramus (CBDR) through antidromic electrical stimulation (ADES) of another CBDR in the adjacent segment. CBDR in the thoracic segments run parallel to each other and no synaptic contact at the periphery is reported. The present study investigated whether the increased sensitivity of peripheral sensory nerves via ADES of a CBDR induced Fos expression changes in the adjacent segments of the spinal cord. Fos expression increased in the T8 - T12 segments of the spinal cord evoked by ADES of the T10 CBDR in rats. The increased Fos expression in the T11 and T12, but not T8 - T10 spinal cord segments, was significantly blocked by local application of either N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine maleate (MK-801) or non-NMDA receptor antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX) into the receptive field of T11 CBDR. The results suggest that endogenous glutamate released by ADES of sensory nerve may bind to peripheral ionotropic glutamate receptors and activate adjacent sensory nerve endings to increase the sensitivity of the spinal cord. These data reveal the potential mechanisms of neuron activation in the spinal cord evoked by peripheral sensitization. Copyright © 2018 Elsevier B.V. All rights reserved.

  11. Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle

    PubMed Central

    Hernández-Ochoa, Erick O; Robison, Patrick; Contreras, Minerva; Shen, Tiansheng; Zhao, Zhiyong; Schneider, Martin F

    2012-01-01

    The transcription factor nuclear factor of activated T-cells 5 (NFAT5) is a key protector from hypertonic stress in the kidney, but its role in skeletal muscle is unexamined. Here, we evaluate the effects of glucose hypertonicity and hyperglycemia on endogenous NFAT5 activity, transverse tubular system morphology and Ca2+ signaling in adult murine skeletal muscle fibers. We found that exposure to elevated glucose (25–50 mmol/L) increased NFAT5 expression and nuclear translocation, and NFAT-driven transcriptional activity. These effects were insensitive to the inhibition of calcineurin A, but sensitive to both p38a mitogen-activated protein kinases and phosphoinositide 3-kinase-related kinase inhibition. Fibers exposed to elevated glucose exhibited disrupted transverse tubular morphology, characterized by swollen transverse tubules and an increase in longitudinal connections between adjacent transverse tubules. Ca2+ transients elicited by a single, brief electric field stimuli were increased in amplitude in fibers challenged by elevated glucose. Muscle fibers from type 1 diabetic mice exhibited increased NFAT5 expression and transverse tubule disruptions, but no differences in electrically evoked Ca2+ transients. Our results suggest the hypothesis that these changes in skeletal muscle could play a role in the pathophysiology of acute and severe hyperglycemic episodes commonly observed in uncontrolled diabetes. PMID:22966145

  12. 30 CFR 18.91 - Electric equipment for which field approvals will be issued.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Electric equipment for which field approvals... OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Field Approval of Electrically Operated Mining Equipment § 18.91 Electric equipment...

  13. 30 CFR 18.91 - Electric equipment for which field approvals will be issued.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Electric equipment for which field approvals... OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Field Approval of Electrically Operated Mining Equipment § 18.91 Electric equipment...

  14. Phosphodiesterase type 4 inhibition enhances nitric oxide- and hydrogen sulfide-mediated bladder neck inhibitory neurotransmission.

    PubMed

    Agis-Torres, Ángel; Recio, Paz; López-Oliva, María Elvira; Martínez, María Pilar; Barahona, María Victoria; Benedito, Sara; Bustamante, Salvador; Jiménez-Cidre, Miguel Ángel; García-Sacristán, Albino; Prieto, Dolores; Fernandes, Vítor S; Hernández, Medardo

    2018-03-16

    Nitric oxide (NO) and hydrogen sulfide (H 2 S) play a pivotal role in nerve-mediated relaxation of the bladder outflow region. In the bladder neck, a marked phosphodiesterase type 4 (PDE4) expression has also been described and PDE4 inhibitors, as rolipram, produce smooth muscle relaxation. This study investigates the role of PDE4 isoenzyme in bladder neck gaseous inhibitory neurotransmission. We used Western blot and double immunohistochemical staining for the detection of NPP4 (PDE4) and PDE4A and organ baths for isometric force recording to roflumilast and tadalafil, PDE4 and PDE5, respectively, inhibitors in pig and human samples. Endogenous H 2 S production measurement and electrical field stimulation (EFS) were also performed. A rich PDE4 and PDE4A expression was observed mainly limited to nerve fibers of the smooth muscle layer of both species. Moreover, roflumilast produced a much more potent smooth muscle relaxation than that induced by tadalafil. In porcine samples, H 2 S generation was diminished by H 2 S and NO synthase inhibition and augmented by roflumilast. Relaxations elicited by EFS were potentiated by roflumilast. These results suggest that PDE4, mainly PDE4A, is mostly located within nerve fibers of the pig and human bladder neck, where roflumilast produces a powerful smooth muscle relaxation. In pig, the fact that roflumilast increases endogenous H 2 S production and EFS-induced relaxations suggests a modulation of PDE4 on NO- and H 2 S-mediated inhibitory neurotransmission.

  15. Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation

    PubMed Central

    Paulk, Angelique C.; Zhou, Yanqiong; Stratton, Peter; Liu, Li

    2013-01-01

    Neural networks in vertebrates exhibit endogenous oscillations that have been associated with functions ranging from sensory processing to locomotion. It remains unclear whether oscillations may play a similar role in the insect brain. We describe a novel “whole brain” readout for Drosophila melanogaster using a simple multichannel recording preparation to study electrical activity across the brain of flies exposed to different sensory stimuli. We recorded local field potential (LFP) activity from >2,000 registered recording sites across the fly brain in >200 wild-type and transgenic animals to uncover specific LFP frequency bands that correlate with: 1) brain region; 2) sensory modality (olfactory, visual, or mechanosensory); and 3) activity in specific neural circuits. We found endogenous and stimulus-specific oscillations throughout the fly brain. Central (higher-order) brain regions exhibited sensory modality-specific increases in power within narrow frequency bands. Conversely, in sensory brain regions such as the optic or antennal lobes, LFP coherence, rather than power, best defined sensory responses across modalities. By transiently activating specific circuits via expression of TrpA1, we found that several circuits in the fly brain modulate LFP power and coherence across brain regions and frequency domains. However, activation of a neuromodulatory octopaminergic circuit specifically increased neuronal coherence in the optic lobes during visual stimulation while decreasing coherence in central brain regions. Our multichannel recording and brain registration approach provides an effective way to track activity simultaneously across the fly brain in vivo, allowing investigation of functional roles for oscillations in processing sensory stimuli and modulating behavior. PMID:23864378

  16. Charged particle mobility refrigerant analyzer

    DOEpatents

    Allman, S.L.; Chunghsuan Chen; Chen, F.C.

    1993-02-02

    A method for analyzing a gaseous electronegative species comprises the steps of providing an analysis chamber; providing an electric field of known potential within the analysis chamber; admitting into the analysis chamber a gaseous sample containing the gaseous electronegative species; providing a pulse of free electrons within the electric field so that the pulse of free electrons interacts with the gaseous electronegative species so that a swarm of electrically charged particles is produced within the electric field; and, measuring the mobility of the electrically charged particles within the electric field.

  17. Charged particle mobility refrigerant analyzer

    DOEpatents

    Allman, Steve L.; Chen, Chung-Hsuan; Chen, Fang C.

    1993-01-01

    A method for analyzing a gaseous electronegative species comprises the steps of providing an analysis chamber; providing an electric field of known potential within the analysis chamber; admitting into the analysis chamber a gaseous sample containing the gaseous electronegative species; providing a pulse of free electrons within the electric field so that the pulse of free electrons interacts with the gaseous electronegative species so that a swarm of electrically charged particles is produced within the electric field; and, measuring the mobility of the electrically charged particles within the electric field.

  18. Measured electric field intensities near electric cloud discharges detected by the Kennedy Space Center's Lightning Detection and Ranging System, LDAR

    NASA Technical Reports Server (NTRS)

    Poehler, H. A.

    1977-01-01

    For a summer thunderstorm, for which simultaneous, airborne electric field measurements and Lightning Detection and Ranging (LDAR) System data was available, measurements were coordinated to present a picture of the electric field intensity near cloud electrical discharges detected by the LDAR System. Radar precipitation echos from NOAA's 10 cm weather radar and measured airborne electric field intensities were superimposed on LDAR PPI plots to present a coordinated data picture of thunderstorm activity.

  19. Modelling of induced electric fields based on incompletely known magnetic fields

    NASA Astrophysics Data System (ADS)

    Laakso, Ilkka; De Santis, Valerio; Cruciani, Silvano; Campi, Tommaso; Feliziani, Mauro

    2017-08-01

    Determining the induced electric fields in the human body is a fundamental problem in bioelectromagnetics that is important for both evaluation of safety of electromagnetic fields and medical applications. However, existing techniques for numerical modelling of induced electric fields require detailed information about the sources of the magnetic field, which may be unknown or difficult to model in realistic scenarios. Here, we show how induced electric fields can accurately be determined in the case where the magnetic fields are known only approximately, e.g. based on field measurements. The robustness of our approach is shown in numerical simulations for both idealized and realistic scenarios featuring a personalized MRI-based head model. The approach allows for modelling of the induced electric fields in biological bodies directly based on real-world magnetic field measurements.

  20. Electric-field-induced structural changes in water confined between two graphene layers

    NASA Astrophysics Data System (ADS)

    Sobrino Fernández, Mario; Peeters, F. M.; Neek-Amal, M.

    2016-07-01

    An external electric field changes the physical properties of polar liquids due to the reorientation of their permanent dipoles. Using molecular dynamics simulations, we predict that an in-plane electric field applied parallel to the channel polarizes water molecules which are confined between two graphene layers, resulting in distinct ferroelectricity and electrical hysteresis. We found that electric fields alter the in-plane order of the hydrogen bonds: Reversing the electric field does not restore the system to the nonpolar initial state, instead a residual dipole moment remains in the system. The square-rhombic structure of 2D ice is transformed into two rhombic-rhombic structures. Our study provides insights into the ferroelectric state of water when confined in nanochannels and shows how this can be tuned by an electric field.

  1. History of research on angiogenesis.

    PubMed

    Ribatti, Domenico

    2014-01-01

    Over the past 25 years, the number of Medline publications dealing with angiogenesis has increased in a nonlinear fashion, reflecting the interest among basic scientists and clinicians in this field. Under physiological conditions, angiogenesis is regulated by the local balance between endogenous stimulators and inhibitors of this process. In tumor growth, there is an imbalance between endogenous stimulator and inhibitor levels, leading to an 'angiogenic switch'. Starting with the hypothesis formulated by Judah Folkman that tumor growth is angiogenesis-dependent, this area of research has a solid scientific foundation and inhibition of angiogenesis is a major area of therapeutic development for the treatment of cancer. This paper offers an account of the most relevant discoveries in this field of biomedical research. Copyright © 2014 S. Karger AG, Basel.

  2. Electric potential and electric field imaging

    NASA Astrophysics Data System (ADS)

    Generazio, E. R.

    2017-02-01

    The technology and methods for remote quantitative imaging of electrostatic potentials and electrostatic fields in and around objects and in free space is presented. Electric field imaging (EFI) technology may be applied to characterize intrinsic or existing electric potentials and electric fields, or an externally generated electrostatic field made be used for "illuminating" volumes to be inspected with EFI. The baseline sensor technology (e-Sensor) and its construction, optional electric field generation (quasi-static generator), and current e-Sensor enhancements (ephemeral e-Sensor) are discussed. Demonstrations for structural, electronic, human, and memory applications are shown. This new EFI capability is demonstrated to reveal characterization of electric charge distribution creating a new field of study embracing areas of interest including electrostatic discharge (ESD) mitigation, crime scene forensics, design and materials selection for advanced sensors, dielectric morphology of structures, tether integrity, organic molecular memory, and medical diagnostic and treatment efficacy applications such as cardiac polarization wave propagation and electromyography imaging.

  3. Imaging electric field dynamics with graphene optoelectronics.

    PubMed

    Horng, Jason; Balch, Halleh B; McGuire, Allister F; Tsai, Hsin-Zon; Forrester, Patrick R; Crommie, Michael F; Cui, Bianxiao; Wang, Feng

    2016-12-16

    The use of electric fields for signalling and control in liquids is widespread, spanning bioelectric activity in cells to electrical manipulation of microstructures in lab-on-a-chip devices. However, an appropriate tool to resolve the spatio-temporal distribution of electric fields over a large dynamic range has yet to be developed. Here we present a label-free method to image local electric fields in real time and under ambient conditions. Our technique combines the unique gate-variable optical transitions of graphene with a critically coupled planar waveguide platform that enables highly sensitive detection of local electric fields with a voltage sensitivity of a few microvolts, a spatial resolution of tens of micrometres and a frequency response over tens of kilohertz. Our imaging platform enables parallel detection of electric fields over a large field of view and can be tailored to broad applications spanning lab-on-a-chip device engineering to analysis of bioelectric phenomena.

  4. Effects of an electric field on the electronic and optical properties of zigzag boron nitride nanotubes

    NASA Astrophysics Data System (ADS)

    Chegel, Raad; Behzad, Somayeh

    2011-02-01

    We have investigated the electro-optical properties of zigzag BNNTs, under an external electric field, using the tight binding approximation. It is found that an electric field modifies the band structure and splits the band degeneracy. Also the large electric strength leads to coupling the neighbor subbands which these effects reflect in the DOS and JDOS spectrum. It has been shown that, unlike CNTs, the band gap of BNNTs can be reduced linearly by applying a transverse external electric field. Also we show that the larger diameter tubes are more sensitive than small ones. The semiconducting metallic transition can be achieved through increasing the applied fields. The number and position of peaks in the JDOS spectrum are dependent on electric field strength. It is found that at a high electric field, the two lowest subbands are oscillatory with multiple nodes at the Fermi level.

  5. Optimization of Pockels electric field in transverse modulated optical voltage sensor

    NASA Astrophysics Data System (ADS)

    Huang, Yifan; Xu, Qifeng; Chen, Kun-Long; Zhou, Jie

    2018-05-01

    This paper investigates the possibilities of optimizing the Pockels electric field in a transverse modulated optical voltage sensor with a spherical electrode structure. The simulations show that due to the edge effect and the electric field concentrations and distortions, the electric field distributions in the crystal are non-uniform. In this case, a tiny variation in the light path leads to an integral error of more than 0.5%. Moreover, a 2D model cannot effectively represent the edge effect, so a 3D model is employed to optimize the electric field distributions. Furthermore, a new method to attach a quartz crystal to the electro-optic crystal along the electric field direction is proposed to improve the non-uniformity of the electric field. The integral error is reduced therefore from 0.5% to 0.015% and less. The proposed method is simple, practical and effective, and it has been validated by numerical simulations and experimental tests.

  6. Creation of vector bosons by an electric field in curved spacetime

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kangal, E. Ersin; Yanar, Hilmi; Havare, Ali

    2014-04-15

    We investigate the creation rate of massive spin-1 bosons in the de Sitter universe by a time-dependent electric field via the Duffin–Kemmer–Petiau (DKP) equation. Complete solutions are given by the Whittaker functions and particle creation rate is computed by using the Bogoliubov transformation technique. We analyze the influence of the electric field on the particle creation rate for the strong and vanishing electric fields. We show that the electric field amplifies the creation rate of charged, massive spin-1 particles. This effect is analyzed by considering similar calculations performed for scalar and spin-1/2 particles. -- Highlights: •Duffin–Kemmer–Petiau equation is solved exactlymore » in the presence of an electrical field. •Solutions were made in (1+1)-dimensional curved spacetime. •Particle creation rate for the de Sitter model is calculated. •Pure gravitational or pure electrical field effect on the creation rate is analyzed.« less

  7. The fragmentation of ethanol cation under an electric field: An ab initio/RRKM study

    NASA Astrophysics Data System (ADS)

    Lu, Hsiu-Feng; Li, F.-Y.; Lin, Chun-Chin; Nagaya, K.; Chao, Ito; Lin, S. H.

    2007-08-01

    We present a theoretical study of ethanol cation under an electric field due to the existence of laser field in order to understand the influence of electric field on the mass spectrum of ethanol. The electric field was applied to the four major reaction channels of an ethanol cation, such as the conversion between C 2H 5OH + and c-C 2H 5OH +, CH 3-elimination and two α-H-eliminations, respectively. The correlation between product distribution and field strength is quite complex due to the different responses of the reactants and transition states toward the external electric field. This makes the product distribution change as field strength varies.

  8. Double-edged effect of electric field on the mechanical property of water-filled carbon nanotubes with an application to nanoscale trigger.

    PubMed

    Ye, Hongfei; Zheng, Yonggang; Zhou, Lili; Zhao, Junfei; Zhang, Hong Wu; Chen, Zhen

    2017-11-08

    Polar water molecules would exhibit extraordinary phenomena under nanoscale confinement. By means of electric field, the water-filled carbon nanotube (CNT) that has been successfully fabricated in laboratory is expected to make distinct responses to the external electricity. Here, we examine the effect of electric field direction on the mechanical property of water-filled CNTs. It is found that the longitudinal electric field enhances but the transversal electric field reduces the elastic modulus and critical buckling stress of water-filled CNTs. The double-edged effect of electric field is attributed to the competition between the axial and circumferential pressures induced by polar water molecules. Furthermore, it is notable that the transversal electric field could result in an internal pressure with elliptical distribution, which is an effective and convenient approach to apply the nonuniform pressure on nanochannels. Based on a pre-strained water-filled CNTs, we design a nanoscale trigger with the evident and rapid height change started through switching the direction of electric field. The reported finding lays a foundation for the electricity-controlled property of nanochannels filled with polar molecules and provides an insight into the design of nanoscale functional devices. © 2017 IOP Publishing Ltd.

  9. Engineering Topological Surface State of Cr-doped Bi2Se3 under external electric field

    NASA Astrophysics Data System (ADS)

    Zhang, Jian-Min; Lian, Ruqian; Yang, Yanmin; Xu, Guigui; Zhong, Kehua; Huang, Zhigao

    2017-03-01

    External electric field control of topological surface states (SSs) is significant for the next generation of condensed matter research and topological quantum devices. Here, we present a first-principles study of the SSs in the magnetic topological insulator (MTI) Cr-doped Bi2Se3 under external electric field. The charge transfer, electric potential, band structure and magnetism of the pure and Cr doped Bi2Se3 film have been investigated. It is found that the competition between charge transfer and spin-orbit coupling (SOC) will lead to an electrically tunable band gap in Bi2Se3 film under external electric field. As Cr atom doped, the charge transfer of Bi2Se3 film under external electric field obviously decreases. Remarkably, the band gap of Cr doped Bi2Se3 film can be greatly engineered by the external electric field due to its special band structure. Furthermore, magnetic coupling of Cr-doped Bi2Se3 could be even mediated via the control of electric field. It is demonstrated that external electric field plays an important role on the electronic and magnetic properties of Cr-doped Bi2Se3 film. Our results may promote the development of electronic and spintronic applications of magnetic topological insulator.

  10. Hy-wire and fast electric field change measurements near an isolated thunderstorm, appendix C

    NASA Technical Reports Server (NTRS)

    Holzworth, R. H.; Levine, D. M.

    1983-01-01

    Electric field measurements near an isolated thunderstorm at 6.4 km distance are presented from both a tethered balloon experiment called Hy-wire and also from ground based fast and slow electric field change systems. Simultaneous measurements were made of the electric fields during several lightning flashes at the beginning of the storm which the data clearly indicate were cloud-to-ground flashes. In addition to providing a comparison between the Hy-wire technique for measuring electric fields and more traditional methods, these data are interesting because the lightning flashes occurred prior to changes in the dc electric field, although Hy-wire measured changes in the dc field of up to 750 V/m in the direction opposite to the fair weather field a short time later. Also, the dc electric field was observed to decay back to its preflash value after each flash. The data suggest that Hy-wire was at the field reversal distance from this storm and suggest the charge realignment was taking place in the cloud with a time constant on the order of 20 seconds.

  11. Nonlinearity in the High-Electric-Field Piezoelectricity of Epitaxial BiFeO3 on SrTiO3

    DTIC Science & Technology

    2012-02-10

    Nonlinearity in the high- electric -field piezoelectricity of epitaxial BiFeO3 on SrTiO3 Pice Chen,1 Rebecca J. Sichel-Tissot,1,a) Ji Young Jo,1,b...field linear response in electric fields higher than 150 MV/m. Time-resolved synchrotron x-ray microdiffraction reveals a low-field piezoelectric...decreases throughout the high- electric -field regime, accompanied by increased diffuse scattering, consistent with lattice softening lattice near a field

  12. Magnetic field controlled electronic state and electric field controlled magnetic state in α-Fe1.6Ga0.4O3 oxide

    NASA Astrophysics Data System (ADS)

    Lone, Abdul Gaffar; Bhowmik, R. N.

    2018-04-01

    We have prepared α-Fe1.6Ga0.4O3 (Ga doped α-Fe2O3) system in rhombohedral phase. The material has shown room temperature ferroelectric and ferromagnetic properties. The existence of magneto-electric coupling at room temperature has been confirmed by the experimental observation of magnetic field controlled electric properties and electric field controlled magnetization. The current-voltage characteristics were controlled by external magnetic field. The magnetic state switching and exchange bias effect are highly sensitive to the polarity and ON and OFF modes of external electric field. Such materials can find novel applications in magneto-electronic devices, especially in the field of electric field controlled spintronics devices and energy storage devices which need low power consumption.

  13. Rates of Charged Clocks in an Electric Field.

    NASA Astrophysics Data System (ADS)

    Ozer, Murat

    2008-04-01

    The gravitational arguments leading to time dilation, redshift, and spacetime curvature are adapted to electric fields. The energy levels of two identical positively charged atoms at different potentials in a static electric field are shown to undergo blueshift. Secondly, the period of a charged simple pendulum (clock) in the electric field of a metallic sphere is shown to vary with the electric potential. The spacetime diagram for the world lines of two photons emitted and absorbed by two pendulums at different potentials at different times and the world lines of the pendulums, as in Schild's argument, is shown to be not a parallelogram in Minkowski spacetime, concluding that spacetime must be curved. A Pound-Rebka-Snider experiment in an electric field is proposed to confirm that photons undergo a frequency shift in an electric field and hence the spacetime manifold is curved. Next, Torretti's gravitational argument that spacetime around a mass distribution concentrated at a point is curved is extended to electric charge distributions to conclude that the nonuniform electric fields of such charge distributions too curve spacetime. Finally, the local equivalence of a uniform electric field times the charge to mass ratio to a uniform acceleration is shown through spacetime transformations and the electrical redshift is obtained in a uniformly accelerated frame by using this principle. These arguments lead to the conclusion that special relativistic electromagnetism is an approximation to a general relativistic multi-metric theory.

  14. Electric toothbrushes induce electric current in fixed dental appliances by creating magnetic fields.

    PubMed

    Kameda, Takashi; Ohkuma, Kazuo; Ishii, Nozomu; Sano, Natsuki; Ogura, Hideo; Terada, Kazuto

    2012-01-01

    Magnetic fields can represent a health problem, especially low frequency electromagnetic fields sometimes induced by electric current in metallic objects worn or used in or on the body (as opposed to high frequency electromagnetic fields that produce heat). Electric toothbrushes are widely used because of their convenience, but the electric motors that power them may produce electromagnetic waves. In this study, we showed that electric toothbrushes generate low frequency (1-2000 Hz) magnetic fields and induce electric current in dental appliances (e. g. orthodontic and prosthetic appliances and dental implants). Current induced by electric toothbrushes might be dependent on the quantity and types of metals used, and the shape of the appliances. Furthermore, these induced currents in dental appliances could impact upon human oral health, producing pain and discomfort.

  15. Characteristics of DC electric fields in transient plasma sheet events

    NASA Astrophysics Data System (ADS)

    Laakso, H. E.; Escoubet, C. P.; Masson, A.

    2015-12-01

    We take an advantage of five different DC electric field measurements in the plasma sheet available from the EFW double probe experiment, EDI electron drift instrument, CODIF and HIA ion spectrometers, and PEACE electron spectrometer on the four Cluster spacecraft. The calibrated observations of the three spectrometers are used to determine the proton and electron velocity moments. The velocity moments can be used to estimate the proton and electron drift velocity and furthermore the DC electric field, assuming that the electron and proton velocity perpendicular to the magnetic field is dominated by the ExB drift motion. Naturally when ions and electrons do not perform a proper drift motion, which can happen in the plasma sheet, the estimated DC electric field from ion and electron motion is not correct. However, surprisingly often the DC electric fields estimated from electron and ion motions are identical suggesting that this field is a real DC electric field around the measurement point. As the measurement techniques are so different, it is quite plausible that when two different measurements yield the same DC electric field, it is the correct field. All five measurements of the DC electric field are usually not simultaneously available, especially on Cluster 2 where CODIF and HIA are not operational, or on Cluster 4 where EDI is off. In this presentation we investigate DC electric field in various transient plasma sheet events such as dipolarization events and BBF's and how the five measurements agree or disagree. There are plenty of important issues that are considered, e.g., (1) what kind of DC electric fields exist in such events and what are their spatial scales, (2) do electrons and ions perform ExB drift motions in these events, and (3) how well the instruments have been calibrated.

  16. Evaluation method for in situ electric field in standardized human brain for different transcranial magnetic stimulation coils

    NASA Astrophysics Data System (ADS)

    Iwahashi, Masahiro; Gomez-Tames, Jose; Laakso, Ilkka; Hirata, Akimasa

    2017-03-01

    This study proposes a method to evaluate the electric field induced in the brain by transcranial magnetic stimulation (TMS) to realize focal stimulation in the target area considering the inter-subject difference of the brain anatomy. The TMS is a non-invasive technique used for treatment/diagnosis, and it works by inducing an electric field in a specific area of the brain via a coil-induced magnetic field. Recent studies that report on the electric field distribution in the brain induced by TMS coils have been limited to simplified human brain models or a small number of detailed human brain models. Until now, no method has been developed that appropriately evaluates the coil performance for a group of subjects. In this study, we first compare the magnetic field and the magnetic vector potential distributions to determine if they can be used as predictors of the TMS focality derived from the electric field distribution. Next, the hotspots of the electric field on the brain surface of ten subjects using six coils are compared. Further, decisive physical factors affecting the focality of the induced electric field by different coils are discussed by registering the computed electric field in a standard brain space for the first time, so as to evaluate coil characteristics for a large population of subjects. The computational results suggest that the induced electric field in the target area cannot be generalized without considering the morphological variability of the human brain. Moreover, there was no remarkable difference between the various coils, although focality could be improved to a certain extent by modifying the coil design (e.g., coil radius). Finally, the focality estimated by the electric field was more correlated with the magnetic vector potential than the magnetic field in a homogeneous sphere.

  17. Evaluation method for in situ electric field in standardized human brain for different transcranial magnetic stimulation coils.

    PubMed

    Iwahashi, Masahiro; Gomez-Tames, Jose; Laakso, Ilkka; Hirata, Akimasa

    2017-03-21

    This study proposes a method to evaluate the electric field induced in the brain by transcranial magnetic stimulation (TMS) to realize focal stimulation in the target area considering the inter-subject difference of the brain anatomy. The TMS is a non-invasive technique used for treatment/diagnosis, and it works by inducing an electric field in a specific area of the brain via a coil-induced magnetic field. Recent studies that report on the electric field distribution in the brain induced by TMS coils have been limited to simplified human brain models or a small number of detailed human brain models. Until now, no method has been developed that appropriately evaluates the coil performance for a group of subjects. In this study, we first compare the magnetic field and the magnetic vector potential distributions to determine if they can be used as predictors of the TMS focality derived from the electric field distribution. Next, the hotspots of the electric field on the brain surface of ten subjects using six coils are compared. Further, decisive physical factors affecting the focality of the induced electric field by different coils are discussed by registering the computed electric field in a standard brain space for the first time, so as to evaluate coil characteristics for a large population of subjects. The computational results suggest that the induced electric field in the target area cannot be generalized without considering the morphological variability of the human brain. Moreover, there was no remarkable difference between the various coils, although focality could be improved to a certain extent by modifying the coil design (e.g., coil radius). Finally, the focality estimated by the electric field was more correlated with the magnetic vector potential than the magnetic field in a homogeneous sphere.

  18. Evaluation of the induced electric field and compliance procedure for a wireless power transfer system in an electrical vehicle.

    PubMed

    Laakso, Ilkka; Hirata, Akimasa

    2013-11-07

    In this study, an induced electric field in a human body is evaluated for the magnetic field leaked from a wireless power transfer system for charging an electrical vehicle. The magnetic field from the wireless power transfer system is modelled computationally, and its effectiveness is confirmed by comparison with the field measured in a previous study. The induced electric field in a human standing around the vehicle is smaller than the allowable limit prescribed in international guidelines, although the magnetic field strength in the human body is locally higher than the allowable external field strength. Correlation between the external magnetic field and the induced electric field is confirmed to be reasonable at least in the standing posture, which is the case discussed in the international standard. Based on this finding, we discussed and confirmed the applicability of a three-point magnetic field measurement at heights of 0.5, 1.0, and 1.5 m for safety compliance.

  19. Ultrafast Electric Field Pulse Control of Giant Temperature Change in Ferroelectrics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Qi, Y.; Liu, S.; Lindenberg, A. M.

    There is a surge of interest in developing environmentally friendly solid-state-based cooling technology. Here, we point out that a fast cooling rate (≈ 10 11 K/s) can be achieved by driving solid crystals to a high-temperature phase with a properly designed electric field pulse. Specifically, we predict that an ultrafast electric field pulse can cause a giant temperature decrease up to 32 K in PbTiO 3 occurring on few picosecond time scales. Here, we explain the underlying physics of this giant electric field pulse-induced temperature change with the concept of internal energy redistribution: the electric field does work on amore » ferroelectric crystal and redistributes its internal energy, and the way the kinetic energy is redistributed determines the temperature change and strongly depends on the electric field temporal profile. This concept is supported by our all-atom molecular dynamics simulations of PbTiO 3 and BaTiO 3. Moreover, this internal energy redistribution concept can also be applied to understand electrocaloric effect. We further propose new strategies for inducing giant cooling effect with ultrafast electric field pulse. This Letter offers a general framework to understand electric-field-induced temperature change and highlights the opportunities of electric field engineering for controlled design of fast and efficient cooling technology.« less

  20. Ultrafast Electric Field Pulse Control of Giant Temperature Change in Ferroelectrics

    DOE PAGES

    Qi, Y.; Liu, S.; Lindenberg, A. M.; ...

    2018-01-30

    There is a surge of interest in developing environmentally friendly solid-state-based cooling technology. Here, we point out that a fast cooling rate (≈ 10 11 K/s) can be achieved by driving solid crystals to a high-temperature phase with a properly designed electric field pulse. Specifically, we predict that an ultrafast electric field pulse can cause a giant temperature decrease up to 32 K in PbTiO 3 occurring on few picosecond time scales. Here, we explain the underlying physics of this giant electric field pulse-induced temperature change with the concept of internal energy redistribution: the electric field does work on amore » ferroelectric crystal and redistributes its internal energy, and the way the kinetic energy is redistributed determines the temperature change and strongly depends on the electric field temporal profile. This concept is supported by our all-atom molecular dynamics simulations of PbTiO 3 and BaTiO 3. Moreover, this internal energy redistribution concept can also be applied to understand electrocaloric effect. We further propose new strategies for inducing giant cooling effect with ultrafast electric field pulse. This Letter offers a general framework to understand electric-field-induced temperature change and highlights the opportunities of electric field engineering for controlled design of fast and efficient cooling technology.« less

  1. Ultrafast Electric Field Pulse Control of Giant Temperature Change in Ferroelectrics

    NASA Astrophysics Data System (ADS)

    Qi, Y.; Liu, S.; Lindenberg, A. M.; Rappe, A. M.

    2018-01-01

    There is a surge of interest in developing environmentally friendly solid-state-based cooling technology. Here, we point out that a fast cooling rate (≈1011 K /s ) can be achieved by driving solid crystals to a high-temperature phase with a properly designed electric field pulse. Specifically, we predict that an ultrafast electric field pulse can cause a giant temperature decrease up to 32 K in PbTiO3 occurring on few picosecond time scales. We explain the underlying physics of this giant electric field pulse-induced temperature change with the concept of internal energy redistribution: the electric field does work on a ferroelectric crystal and redistributes its internal energy, and the way the kinetic energy is redistributed determines the temperature change and strongly depends on the electric field temporal profile. This concept is supported by our all-atom molecular dynamics simulations of PbTiO3 and BaTiO3 . Moreover, this internal energy redistribution concept can also be applied to understand electrocaloric effect. We further propose new strategies for inducing giant cooling effect with ultrafast electric field pulse. This Letter offers a general framework to understand electric-field-induced temperature change and highlights the opportunities of electric field engineering for controlled design of fast and efficient cooling technology.

  2. Effects of an electric field on white sharks: in situ testing of an electric deterrent.

    PubMed

    Huveneers, Charlie; Rogers, Paul J; Semmens, Jayson M; Beckmann, Crystal; Kock, Alison A; Page, Brad; Goldsworthy, Simon D

    2013-01-01

    Elasmobranchs can detect minute electromagnetic fields, <1 nV cm(-1), using their ampullae of Lorenzini. Behavioural responses to electric fields have been investigated in various species, sometimes with the aim to develop shark deterrents to improve human safety. The present study tested the effects of the Shark Shield Freedom7™ electric deterrent on (1) the behaviour of 18 white sharks (Carcharodon carcharias) near a static bait, and (2) the rates of attacks on a towed seal decoy. In the first experiment, 116 trials using a static bait were performed at the Neptune Islands, South Australia. The proportion of baits taken during static bait trials was not affected by the electric field. The electric field, however, increased the time it took them to consume the bait, the number of interactions per approach, and decreased the proportion of interactions within two metres of the field source. The effect of the electric field was not uniform across all sharks. In the second experiment, 189 tows using a seal decoy were conducted near Seal Island, South Africa. No breaches and only two surface interactions were observed during the tows when the electric field was activated, compared with 16 breaches and 27 surface interactions without the electric field. The present study suggests that the behavioural response of white sharks and the level of risk reduction resulting from the electric field is contextually specific, and depends on the motivational state of sharks.

  3. Basic Restriction and Reference Level in Anatomically-based Japanese Models for Low-Frequency Electric and Magnetic Field Exposures

    NASA Astrophysics Data System (ADS)

    Takano, Yukinori; Hirata, Akimasa; Fujiwara, Osamu

    Human exposed to electric and/or magnetic fields at low frequencies may cause direct effect such as nerve stimulation and excitation. Therefore, basic restriction is regulated in terms of induced current density in the ICNIRP guidelines and in-situ electric field in the IEEE standard. External electric or magnetic field which does not produce induced quantities exceeding the basic restriction is used as a reference level. The relationship between the basic restriction and reference level for low-frequency electric and magnetic fields has been investigated using European anatomic models, while limited for Japanese model, especially for electric field exposures. In addition, that relationship has not well been discussed. In the present study, we calculated the induced quantities in anatomic Japanese male and female models exposed to electric and magnetic fields at reference level. A quasi static finite-difference time-domain (FDTD) method was applied to analyze this problem. As a result, spatially averaged induced current density was found to be more sensitive to averaging algorithms than that of in-situ electric field. For electric and magnetic field exposure at the ICNIRP reference level, the maximum values of the induced current density for different averaging algorithm were smaller than the basic restriction for most cases. For exposures at the reference level in the IEEE standard, the maximum electric fields in the brain were larger than the basic restriction in the brain while smaller for the spinal cord and heart.

  4. Effect of multilayer structure, stacking order and external electric field on the electrical properties of few-layer boron-phosphide.

    PubMed

    Chen, Xianping; Tan, Chunjian; Yang, Qun; Meng, Ruishen; Liang, Qiuhua; Jiang, Junke; Sun, Xiang; Yang, D Q; Ren, Tianling

    2016-06-28

    Development of nanoelectronics requires two-dimensional (2D) systems with both direct-bandgap and tunable electronic properties as they act in response to the external electric field (E-field). Here, we present a detailed theoretical investigation to predict the effect of atomic structure, stacking order and external electric field on the electrical properties of few-layer boron-phosphide (BP). We demonstrate that the splitting of bands and bandgap of BP depends on the number of layers and the stacking order. The values for the bandgap show a monotonically decreasing relationship with increasing layer number. We also show that AB-stacking BP has a direct-bandgap, while ABA-stacking BP has an indirect-bandgap when the number of layers n > 2. In addition, for a bilayer and a trilayer, the bandgap increases (decreases) as the electric field increases along the positive direction of the external electric field (E-field) (negative direction). In the case of four-layer BP, the bandgap exhibits a nonlinearly decreasing behavior as the increase in the electric field is independent of the electric field direction. The tunable mechanism of the bandgap can be attributed to a giant Stark effect. Interestingly, the investigation also shows that a semiconductor-to-metal transition may occur for the four-layer case or more layers beyond the critical electric field. Our findings may inspire more efforts in fabricating new nanoelectronics devices based on few-layer BP.

  5. Effects of an Electric Field on White Sharks: In Situ Testing of an Electric Deterrent

    PubMed Central

    Huveneers, Charlie; Rogers, Paul J.; Semmens, Jayson M.; Beckmann, Crystal; Kock, Alison A.; Page, Brad; Goldsworthy, Simon D.

    2013-01-01

    Elasmobranchs can detect minute electromagnetic fields, <1 nVcm–1, using their ampullae of Lorenzini. Behavioural responses to electric fields have been investigated in various species, sometimes with the aim to develop shark deterrents to improve human safety. The present study tested the effects of the Shark Shield Freedom7™ electric deterrent on (1) the behaviour of 18 white sharks (Carcharodon carcharias) near a static bait, and (2) the rates of attacks on a towed seal decoy. In the first experiment, 116 trials using a static bait were performed at the Neptune Islands, South Australia. The proportion of baits taken during static bait trials was not affected by the electric field. The electric field, however, increased the time it took them to consume the bait, the number of interactions per approach, and decreased the proportion of interactions within two metres of the field source. The effect of the electric field was not uniform across all sharks. In the second experiment, 189 tows using a seal decoy were conducted near Seal Island, South Africa. No breaches and only two surface interactions were observed during the tows when the electric field was activated, compared with 16 breaches and 27 surface interactions without the electric field. The present study suggests that the behavioural response of white sharks and the level of risk reduction resulting from the electric field is contextually specific, and depends on the motivational state of sharks. PMID:23658766

  6. Cryosurgery with pulsed electric fields.

    PubMed

    Daniels, Charlotte S; Rubinsky, Boris

    2011-01-01

    This study explores the hypothesis that combining the minimally invasive surgical techniques of cryosurgery and pulsed electric fields will eliminate some of the major disadvantages of these techniques while retaining their advantages. Cryosurgery, tissue ablation by freezing, is a well-established minimally invasive surgical technique. One disadvantage of cryosurgery concerns the mechanism of cell death; cells at high subzero temperature on the outer rim of the frozen lesion can survive. Pulsed electric fields (PEF) are another minimally invasive surgical technique in which high strength and very rapid electric pulses are delivered across cells to permeabilize the cell membrane for applications such as gene delivery, electrochemotherapy and irreversible electroporation. The very short time scale of the electric pulses is disadvantageous because it does not facilitate real time control over the procedure. We hypothesize that applying the electric pulses during the cryosurgical procedure in such a way that the electric field vector is parallel to the heat flux vector will have the effect of confining the electric fields to the frozen/cold region of tissue, thereby ablating the cells that survive freezing while facilitating controlled use of the PEF in the cold confined region. A finite element analysis of the electric field and heat conduction equations during simultaneous tissue treatment with cryosurgery and PEF (cryosurgery/PEF) was used to study the effect of tissue freezing on electric fields. The study yielded motivating results. Because of decreased electrical conductivity in the frozen/cooled tissue, it experienced temperature induced magnified electric fields in comparison to PEF delivered to the unfrozen tissue control. This suggests that freezing/cooling confines and magnifies the electric fields to those regions; a targeting capability unattainable in traditional PEF. This analysis shows how temperature induced magnified and focused PEFs could be used to ablate cells in the high subzero freezing region of a cryosurgical lesion.

  7. Electric-field-induced structural changes in multilayer piezoelectric actuators during electrical and mechanical loading

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Esteves, Giovanni; Fancher, Chris M.; Röhrig, Sören

    The effects of electrical and mechanical loading on the behavior of domains and phases in Multilayer Piezoelectric Actuators (MAs) is studied using in situ high-energy X-ray diffraction (XRD) and macroscopic property measurements. Rietveld refinement is carried out on measured diffraction patterns using a two-phase tetragonal (P4mm) and rhombohedral (R3m) model. Applying an electric field promotes the rhombohedral phase, while increasing compressive uniaxial pre-stress prior to electric field application favors the tetragonal phase. The competition between electrical and mechanical energy leads to a maximal difference between electric-field-induced phase fractions at 70 MPa pre-stress. Additionally, the available volume fraction of non-180° domainmore » reorientation that can be accessed during electric field application increases with compressive pre-stress up to 70 MPa. The origin for enhanced strain and polarization with applied pre-stress is attributed to a combination of enhanced non-180° domain reorientation and electric-field-induced phase transitions. The suppression of both the electric-field-induced phase transitions and domain reorientation at high pre-stresses (>70 MPa) is attributed to a large mechanical energy barrier, and alludes to the competition of the electrical and mechanical energy within the MA during applied stimuli.« less

  8. Electric-field-induced structural changes in multilayer piezoelectric actuators during electrical and mechanical loading

    DOE PAGES

    Esteves, Giovanni; Fancher, Chris M.; Röhrig, Sören; ...

    2017-04-08

    The effects of electrical and mechanical loading on the behavior of domains and phases in Multilayer Piezoelectric Actuators (MAs) is studied using in situ high-energy X-ray diffraction (XRD) and macroscopic property measurements. Rietveld refinement is carried out on measured diffraction patterns using a two-phase tetragonal (P4mm) and rhombohedral (R3m) model. Applying an electric field promotes the rhombohedral phase, while increasing compressive uniaxial pre-stress prior to electric field application favors the tetragonal phase. The competition between electrical and mechanical energy leads to a maximal difference between electric-field-induced phase fractions at 70 MPa pre-stress. Additionally, the available volume fraction of non-180° domainmore » reorientation that can be accessed during electric field application increases with compressive pre-stress up to 70 MPa. The origin for enhanced strain and polarization with applied pre-stress is attributed to a combination of enhanced non-180° domain reorientation and electric-field-induced phase transitions. The suppression of both the electric-field-induced phase transitions and domain reorientation at high pre-stresses (>70 MPa) is attributed to a large mechanical energy barrier, and alludes to the competition of the electrical and mechanical energy within the MA during applied stimuli.« less

  9. The coil orientation dependency of the electric field induced by TMS for M1 and other brain areas.

    PubMed

    Janssen, Arno M; Oostendorp, Thom F; Stegeman, Dick F

    2015-05-17

    The effectiveness of transcranial magnetic stimulation (TMS) depends highly on the coil orientation relative to the subject's head. This implies that the direction of the induced electric field has a large effect on the efficiency of TMS. To improve future protocols, knowledge about the relationship between the coil orientation and the direction of the induced electric field on the one hand, and the head and brain anatomy on the other hand, seems crucial. Therefore, the induced electric field in the cortex as a function of the coil orientation has been examined in this study. The effect of changing the coil orientation on the induced electric field was evaluated for fourteen cortical targets. We used a finite element model to calculate the induced electric fields for thirty-six coil orientations (10 degrees resolution) per target location. The effects on the electric field due to coil rotation, in combination with target site anatomy, have been quantified. The results confirm that the electric field perpendicular to the anterior sulcal wall of the central sulcus is highly susceptible to coil orientation changes and has to be maximized for an optimal stimulation effect of the motor cortex. In order to obtain maximum stimulation effect in areas other than the motor cortex, the electric field perpendicular to the cortical surface in those areas has to be maximized as well. Small orientation changes (10 degrees) do not alter the induced electric field drastically. The results suggest that for all cortical targets, maximizing the strength of the electric field perpendicular to the targeted cortical surface area (and inward directed) optimizes the effect of TMS. Orienting the TMS coil based on anatomical information (anatomical magnetic resonance imaging data) about the targeted brain area can improve future results. The standard coil orientations, used in cognitive and clinical neuroscience, induce (near) optimal electric fields in the subject-specific head model in most cases.

  10. Probing the plasma near high power wave launchers in fusion devices for static and dynamic electric fields

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Klepper, C Christopher; Martin, Elijah H; Isler, Ralph C

    2014-01-01

    An exploratory study was carried out in the long-pulse tokamak Tore Supra, to determine if electric fields in the plasma around high-power, RF wave launchers could be measured with non-intrusive, passive, optical emission spectroscopy. The focus was in particular on the use of the external electric field Stark effect. The feasibility was found to be strongly dependent on the spatial extent of the electric fields and overlap between regions of strong (> 1 kV/cm) electric fields and regions of plasma particle recycling and plasma-induced, spectral line emission. Most amenable to the measurement was the RF electric field in edge plasma,more » in front of a lower hybrid heating and current drive launcher. Electric field strengths and direction, derived from fitting the acquired spectra to a model including time-dependent Stark effect and the tokamak-range magnetic field Zeeman-effect, were found to be in good agreement with full-wave modeling of the observed launcher.« less

  11. Probing the plasma near high power wave launchers in fusion devices for static and dynamic electric fields (invited)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Klepper, C. C., E-mail: kleppercc@ornl.gov; Isler, R. C.; Biewer, T. M.

    2014-11-15

    An exploratory study was carried out in the long-pulse tokamak Tore Supra, to determine if electric fields in the plasma around high-power, RF wave launchers could be measured with non-intrusive, passive, optical emission spectroscopy. The focus was in particular on the use of the external electric field Stark effect. The feasibility was found to be strongly dependent on the spatial extent of the electric fields and overlap between regions of strong (>∼1 kV/cm) electric fields and regions of plasma particle recycling and plasma-induced, spectral line emission. Most amenable to the measurement was the RF electric field in edge plasma, inmore » front of a lower hybrid heating and current drive launcher. Electric field strengths and direction, derived from fitting the acquired spectra to a model including time-dependent Stark effect and the tokamak-range magnetic field Zeeman-effect, were found to be in good agreement with full-wave modeling of the observed launcher.« less

  12. Probing the plasma near high power wave launchers in fusion devices for static and dynamic electric fields (invited).

    PubMed

    Klepper, C C; Martin, E H; Isler, R C; Colas, L; Goniche, M; Hillairet, J; Panayotis, S; Pegourié, B; Jacquot, J; Lotte, Ph; Colledani, G; Biewer, T M; Caughman, J B; Ekedahl, A; Green, D L; Harris, J H; Hillis, D L; Shannon, S C; Litaudon, X

    2014-11-01

    An exploratory study was carried out in the long-pulse tokamak Tore Supra, to determine if electric fields in the plasma around high-power, RF wave launchers could be measured with non-intrusive, passive, optical emission spectroscopy. The focus was in particular on the use of the external electric field Stark effect. The feasibility was found to be strongly dependent on the spatial extent of the electric fields and overlap between regions of strong (>∼1 kV/cm) electric fields and regions of plasma particle recycling and plasma-induced, spectral line emission. Most amenable to the measurement was the RF electric field in edge plasma, in front of a lower hybrid heating and current drive launcher. Electric field strengths and direction, derived from fitting the acquired spectra to a model including time-dependent Stark effect and the tokamak-range magnetic field Zeeman-effect, were found to be in good agreement with full-wave modeling of the observed launcher.

  13. Manipulation of a neutral and nonpolar nanoparticle in water using a nonuniform electric field

    NASA Astrophysics Data System (ADS)

    Xu, Zhen; Wang, Chunlei; Sheng, Nan; Hu, Guohui; Zhou, Zhewei; Fang, Haiping

    2016-01-01

    The manipulation of nanoparticles in water is of essential importance in chemical physics, nanotechnology, medical technology, and biotechnology applications. Generally, a particle with net charges or charge polarity can be driven by an electric field. However, many practical particles only have weak and even negligible charge and polarity, which hinders the electric field to exert a force large enough to drive these nanoparticles directly. Here, we use molecular dynamics simulations to show that a neutral and nonpolar nanoparticle in liquid water can be driven directionally by an external electric field. The directed motion benefits from a nonuniform water environment produced by a nonuniform external electric field, since lower water energies exist under a higher intensity electric field. The nanoparticle spontaneously moves toward locations with a weaker electric field intensity to minimize the energy of the whole system. Considering that the distance between adjacent regions of nonuniform field intensity can reach the micrometer scale, this finding provides a new mechanism of manipulating nanoparticles from the nanoscale to the microscale.

  14. General Matrix Inversion for the Calibration of Electric Field Sensor Arrays on Aircraft Platforms

    NASA Technical Reports Server (NTRS)

    Mach, D. M.; Koshak, W. J.

    2006-01-01

    We have developed a matrix calibration procedure that uniquely relates the electric fields measured at the aircraft with the external vector electric field and net aircraft charge. Our calibration method is being used with all of our aircraft/electric field sensing combinations and can be generalized to any reasonable combination of electric field measurements and aircraft. We determine a calibration matrix that represents the individual instrument responses to the external electric field. The aircraft geometry and configuration of field mills (FMs) uniquely define the matrix. The matrix can then be inverted to determine the external electric field and net aircraft charge from the FM outputs. A distinct advantage of the method is that if one or more FMs need to be eliminated or de-emphasized (for example, due to a malfunction), it is a simple matter to reinvert the matrix without the malfunctioning FMs. To demonstrate our calibration technique, we present data from several of our aircraft programs (ER-2, DC-8, Altus, Citation).

  15. Tip-Enhanced Photoinduced Electron Transfer and Ionization on Vertical Silicon Nanowires.

    PubMed

    Chen, Xiaoming; Wang, Tao; Lin, Leimiao; Wo, Fangjie; Liu, Yaqin; Liang, Xiao; Ye, Hui; Wu, Jianmin

    2018-05-02

    Nanostructured semiconductors are one of the most potent candidates for matrix-free laser desorption/ionization mass spectrometric (LDI-MS) analysis of low-molecular-weight molecules. Herein, the enhanced photoinduced electron transfer and LDI on the tip of a vertical silicon nanowire (SiNW) array were investigated. Theoretical simulation and LDI detection of indigo and isatin molecules in negative ion mode revealed that the electric field can be enhanced on the tip end of SiNWs, thereby promoting the energy and electron transfer to the analytes adsorbed on the tip of SiNWs. On the basis of this finding, a tip-contact sampling method coupled with LDI-MS detection was established. In this strategy, the tip of SiNWs can be regarded as microextraction heads for the sampling of molecules when they come in contact with analytes. Impression of skin, tissue, and pericarp on the vertical SiNW array can effectively transfer endogenous metabolites or exogenous substances onto the tip. Upon laser irradiation, the adsorbed molecules on the SiNW tip can be efficiently ionized and detected in negative ion mode because of the tip-enhanced electron transfer and LDI effect. We believe this work may significantly expand the application of LDI-MS in various fields.

  16. Exposure assessment of extremely low frequency electric fields in Tehran, Iran, 2010.

    PubMed

    Nassiri, Parvin; Esmaeilpour, Mohammad Reza Monazzam; Gharachahi, Ehsan; Haghighat, Gholamali; Yunesian, Masoud; Zaredar, Narges

    2013-01-01

    Extremely Low-Frequency (ELF) electric and magnetic fields belonging to the nonionizing electromagnetic radiation spectrum have a frequency of 50 - 60 Hz. All people are exposed to a complex set of electric and magnetic fields that spread throughout the environment. The current study was carried out to assess people's exposure to an ELF electric field in the Tehran metropolitan area in 2010. The measurement of the electronic fields was performed using an HI-3604 power frequency field strength measurement device. A total number of 2,753 measurements were performed. Afterward, the data obtained were transferred to the base map using Arc View Version 3.2 and Arc Map Version 9.3. Finally, an interpolation method was applied to expand the intensity of the electric field to the entire city. Based on the results obtained, the electric field was divided into three parts with various intensities including 0-5 V m, 5-15 V m, and >15 V m. It should be noted that the status of high voltage transmission lines, electric substations, and specific points including schools and hospitals were also marked on the map. Minimum and maximum electric field intensities were measured tantamount to 0.31 V m and 19.80 V m, respectively. In all measurements, the electric field was much less than the amount provided in the ICNIRP Guide. The results revealed that 141 hospitals and 6,905 schools are situated in an area with electric field intensity equal to 0-5 V m, while 15 hospitals and 95 schools are located in zones of 5-15 V m and more than 15 V m. Examining high voltage transmission lines and electric substations in Tehran and its suburbs suggested that the impact of the lines on the background electric field of the city was low. Accordingly, 0.97 km of Tehran located on the city border adjacent to the high voltage transmission lines have an electric field in the range of 5 to 15 V m. The noted range is much lower than the available standards. In summary, it can be concluded that the public is not exposed to a risky background electric field in metropolitan Tehran. The result of comparing sensitive recipients showed that the schools have a more desirable status than the hospitals. Nonetheless, epidemiologic studies can lead to more understanding of the impact on public health.

  17. Response of ionospheric electric fields at mid-low latitudes during sudden commencements

    NASA Astrophysics Data System (ADS)

    Takahashi, N.; Kasaba, Y.; Shinbori, A.; Nishimura, Y.; Kikuchi, T.; Ebihara, Y.; Nagatsuma, T.

    2015-06-01

    Using in situ observations from the Republic of China Satellite-1 spacecraft, we investigated the time response and local time dependence of the ionospheric electric field at mid-low latitudes associated with geomagnetic sudden commencements (SCs) that occurred from 1999 to 2004. We found that the ionospheric electric field variation associated with SCs instantaneously responds to the preliminary impulse (PI) signature on the ground regardless of spacecraft local time. Our statistical analysis also supports the global instant transmission of electric field from the polar region. In contrast, the peak time detected in the ionospheric electric field is earlier than that of the equatorial geomagnetic field (~20 s before in the PI phase). Based on the ground-ionosphere waveguide model, this time lag can be attributed to the latitudinal difference of ionospheric conductivity. However, the local time distribution of the initial excursion of ionospheric electric field shows that dusk-to-dawn ionospheric electric fields develop during the PI phase. Moreover, the westward electric field in the ionosphere, which produces the preliminary reverse impulse of the geomagnetic field on the dayside feature, appears at 18-22 h LT where the ionospheric conductivity beyond the duskside terminator (18 h LT) is lower than on the dayside. The result of a magnetohydrodynamic simulation for an ideal SC shows that the electric potential distribution is asymmetric with respect to the noon-midnight meridian. This produces the local time distribution of ionospheric electric fields similar to the observed result, which can be explained by the divergence of the Hall current under nonuniform ionospheric conductivity.

  18. Contributions of poroelastic-wave potentials to seismoelectromagnetic wavefields and validity of the quasi-static calculation: a view from a borehole model

    NASA Astrophysics Data System (ADS)

    Guan, Wei; Shi, Peng; Hu, Hengshan

    2018-01-01

    In this study, we theoretically analyse the contributions of the four poroelastic-wave potentials to seismoelectromagnetic (SEM) wavefields, verify the validity of the quasi-static calculation of the electric field and provide a method to calculate the magnetic field by using the curl-free electric field. Calculations show that both the fast and slow P waves and the SH and SV waves have non-negligible contributions to the SEM fields. The S waves have indirect contribution to the electric field through the EM conversion from the magnetic field, although the direct contribution due to streaming current is negligible if EM wavenumbers are much smaller than those of the S waves. The P waves have indirect contribution to the magnetic field through EM conversion from the electric field, although the direct contribution is absent. The quasi-static calculation of the electric field is practicable since it is normally satisfied in reality that the EM wavenumbers are much smaller than those of poroelastic waves. While the direct contribution of the S waves and the higher-order EM conversions are ignored, the first-order EM conversion from the S-wave-induced magnetic field is reserved through the continuity of the electric-current density. To calculate the magnetic field on this basis, we separate the quasi-static electric field into a rotational and an irrotational part. The magnetic-field solutions are derived through Hertz vectors in which the coefficients of the magnetic Hertz vector are determined from the magnetic-field continuities and those of the electric Hertz vector originate from the irrotational part of the quasi-static electric field.

  19. Microscopic Investigation into the Electric Field Effect on Proximity-Induced Magnetism in Pt

    NASA Astrophysics Data System (ADS)

    Yamada, K. T.; Suzuki, M.; Pradipto, A.-M.; Koyama, T.; Kim, S.; Kim, K.-J.; Ono, S.; Taniguchi, T.; Mizuno, H.; Ando, F.; Oda, K.; Kakizakai, H.; Moriyama, T.; Nakamura, K.; Chiba, D.; Ono, T.

    2018-04-01

    Electric field effects on magnetism in metals have attracted widespread attention, but the microscopic mechanism is still controversial. We experimentally show the relevancy between the electric field effect on magnetism and on the electronic structure in Pt in a ferromagnetic state using element-specific measurements: x-ray magnetic circular dichroism (XMCD) and x-ray absorption spectroscopy (XAS). Electric fields are applied to the surface of ultrathin metallic Pt, in which a magnetic moment is induced by the ferromagnetic proximity effect resulting from a Co underlayer. XMCD and XAS measurements performed under the application of electric fields reveal that both the spin and orbital magnetic moments of Pt atoms are electrically modulated, which can be explained not only by the electric-field-induced shift of the Fermi level but also by the change in the orbital hybridizations.

  20. Modelling and assessment of the electric field strength caused by mobile phone to the human head.

    PubMed

    Buckus, Raimondas; Strukcinskiene, Birute; Raistenskis, Juozas; Stukas, Rimantas

    2016-06-01

    Electromagnetic field exposure is the one of the most important physical agents that actively affects live organisms and environment. Active use of mobile phones influences the increase of electromagnetic field radiation. The aim of the study was to measure and assess the electric field strength caused by mobile phones to the human head. In this paper the software "COMSOL Multiphysics" was used to establish the electric field strength created by mobile phones around the head. The second generation (2G) Global System for Mobile (GSM) phones that operate in the frequency band of 900 MHz and reach the power of 2 W have a stronger electric field than (2G) GSM mobile phones that operate in the higher frequency band of 1,800 MHz and reach the power up to 1 W during conversation. The third generation of (3G) UMTS smart phones that effectively use high (2,100 MHz) radio frequency band emit the smallest electric field strength values during conversation. The highest electric field strength created by mobile phones is around the ear, i.e. the mobile phone location. The strength of mobile phone electric field on the phantom head decreases exponentially while moving sidewards from the center of the effect zone (the ear), and constitutes 1-12% of the artificial head's surface. The highest electric field strength values of mobile phones are associated with their higher power, bigger specific energy absorption rate (SAR) and lower frequency of mobile phone. The stronger electric field emitted by the more powerful mobile phones takes a higher percentage of the head surface. The highest electric field strength created by mobile phones is distributed over the user's ear.

  1. Linear electric field time-of-flight ion mass spectrometer

    DOEpatents

    Funsten, Herbert O [Los Alamos, NM; Feldman, William C [Los Alamos, NM

    2008-06-10

    A linear electric field ion mass spectrometer having an evacuated enclosure with means for generating a linear electric field located in the evacuated enclosure and means for injecting a sample material into the linear electric field. A source of pulsed ionizing radiation injects ionizing radiation into the linear electric field to ionize atoms or molecules of the sample material, and timing means determine the time elapsed between ionization of atoms or molecules and arrival of an ion out of the ionized atoms or molecules at a predetermined position.

  2. Electric field effects on the optical properties of buckled GaAs monolayer

    NASA Astrophysics Data System (ADS)

    Bahuguna, Bhagwati Prasad; Saini, L. K.; Sharma, Rajesh O.

    2018-04-01

    Buckled GaAs monolayer has a direct band gap semiconductor with energy gap of 1.31 eV in the absence of electric field. When we applied transverse electric field, the value of band gap decreases with increasing of electric field strength. In our previous work [1], it is observed that the buckled GaAs monolayer becomes metallic at 1.3 V/Å. In the present work, we investigate the optical properties such as photon energy-dependent dielectric functions, extinction coefficient, refractive index, absorption spectrum and reflectivity of buckled GaAs monolayer in the semiconducting phase i.e. absence of external electric field and metallic phase i.e. presence of external electric field using density functional theory.

  3. Underwater electric field detection system based on weakly electric fish

    NASA Astrophysics Data System (ADS)

    Xue, Wei; Wang, Tianyu; Wang, Qi

    2018-04-01

    Weakly electric fish sense their surroundings in complete darkness by their active electric field detection system. However, due to the insufficient detection capacity of the electric field, the detection distance is not enough, and the detection accuracy is not high. In this paper, a method of underwater detection based on rotating current field theory is proposed to improve the performance of underwater electric field detection system. First of all, we built underwater detection system based on the theory of the spin current field mathematical model with the help of the results of previous researchers. Then we completed the principle prototype and finished the metal objects in the water environment detection experiments, laid the foundation for the further experiments.

  4. Multipactor susceptibility on a dielectric with a bias dc electric field and a background gas

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang Peng; Lau, Y. Y.; Franzi, Matthew

    2011-05-15

    We use Monte Carlo simulations and analytical calculations to derive the condition for the onset of multipactor discharge on a dielectric surface at various combinations of the bias dc electric field, rf electric field, and background pressures of noble gases, such as Argon. It is found that the presence of a tangential bias dc electric field on the dielectric surface lowers the magnitude of rf electric field threshold to initiate multipactor, therefore plausibly offering robust protection against high power microwaves. The presence of low pressure gases may lead to a lower multipactor saturation level, however. The combined effects of tangentialmore » dc electric field and external gases on multipactor susceptibility are presented.« less

  5. Electric field control of magnetic properties in FeRh/PMN-PT heterostructures

    NASA Astrophysics Data System (ADS)

    Xie, Yali; Zhan, Qingfeng; Shang, Tian; Yang, Huali; Liu, Yiwei; Wang, Baomin; Li, Run-Wei

    2018-05-01

    We investigated electric control of magnetic properties in FeRh/PMN-PT heterostructures. An electric field of 1 kV/cm applied on the PMN-PT substrate could increase the coercivity of FeRh film from 60 to 161 Oe at 360 K where the FeRh antiferromagnetic to ferromagnetic phase transition occurs. The electric field dependent coercive field reveals a butterfly shape, indicating a strain-mediated magnetoelectric coupling across the FeRh/PMN-PT interface. However, the uniaxial magnetic anisotropy of FeRh is almost unchanged with the applied electric field on the PMN-PT substrate, which suggests the change of coercivity in FeRh films is mainly due to the shift of the magnetic transition temperature under the electric field.

  6. Measured electric field in the vicinity of a thunderstorm system at an altitude of 37 km

    NASA Technical Reports Server (NTRS)

    Benbrook, J. R.; Kern, J. W.; Sheldon, W. R.

    1974-01-01

    A balloon-borne experiment to measure the atmospheric electric field was flown from the National Scientific Balloon Facility at Palestine, Texas, on July 10, 1973. The electric field and atmospheric conductivity were measured during ascent and for a 4-hour float period at 37-km altitude. Termination of the flight occurred near a thunderstorm line in west Texas. The perturbing influence of the thunderstorms on the electric field was observed at least 100 km from the storm line. The measured electric field is in reasonable agreement with calculations based on simple models of cloud structure and atmospheric conductivity. Large pulses in the measured electric field are interpreted as being the result of intracloud lightning.

  7. Characteristics of DC electric fields at dipolarization fronts

    NASA Astrophysics Data System (ADS)

    Laakso, Harri; Escoubet, Philippe; Masson, Arnaud

    2016-04-01

    We investigate the characteristics of DC electric field at dipolarization fronts and BBF's using multi-point Cluster observations. There are plenty of important issues that are considered, such as what kind of DC electric fields exist in such events and what are their spatial scales. One can also recognize if electrons and ions perform ExB drift motions in these events. To investigate this, we take an advantage of five different DC electric field measurements in the plasma sheet available from the EFW double probe experiment, EDI electron drift instrument, CODIF and HIA ion spectrometers, and PEACE electron spectrometer. The calibrated observations of the three spectrometers are used to determine the proton and electron drift velocity and furthermore the DC electric field, assuming that the electron and proton velocity perpendicular to the magnetic field is dominated by the ExB drift motion. Naturally when ions and electrons do not perform a proper drift motion, which can happen in the plasma sheet, the estimated DC electric field from ion and electron motion is not correct. However, surprisingly often the DC electric fields estimated from electron and ion motions are identical suggesting that this field is a real DC electric field around the measurement point. This investigation also helps understand how well different measurements are calibrated.

  8. Gate control of quantum dot-based electron spin-orbit qubits

    NASA Astrophysics Data System (ADS)

    Wu, Shudong; Cheng, Liwen; Yu, Huaguang; Wang, Qiang

    2018-07-01

    We investigate theoretically the coherent spin dynamics of gate control of quantum dot-based electron spin-orbit qubits subjected to a tilted magnetic field under electric-dipole spin resonance (EDSR). Our results reveal that Rabi oscillation of qubit states can be manipulated electrically based on rapid gate control of SOC strength. The Rabi frequency is strongly dependent on the gate-induced electric field, the strength and orientation of the applied magnetic field. There are two major EDSR mechanisms. One arises from electric field-induced spin-orbit hybridization, and the other arises from magnetic field-induced energy-level crossing. The SOC introduced by the gate-induced electric field allows AC electric fields to drive coherent Rabi oscillations between spin-up and -down states. After the crossing of the energy-levels with the magnetic field, the spin-transfer crossing results in Rabi oscillation irrespective of whether or not the external electric field is present. The spin-orbit qubit is transferred into the orbit qubit. Rabi oscillation is anisotropic and periodic with respect to the tilted and in-plane orientation of the magnetic field originating from the interplay of the SOC, orbital, and Zeeman effects. The strong electrically-controlled SOC strength suggests the possibility for scalable applications of gate-controllable spin-orbit qubits.

  9. Mars Atmospheric Chemistry in Electrified Dust Devils and Storms

    NASA Technical Reports Server (NTRS)

    Farrell, W. M.; Delory, G. T.; Atreya, S. K.; Wong, A.-S.; Renno, N. O.; Sentmann, D. D.; Marshall, J. G.; Cummer, S. A.; Rafkin, S.; Catling, D.

    2005-01-01

    Laboratory studies, simulations and desert field tests all indicate that aeolian mixing dust can generate electricity via contact electrification or "triboelectricity". In convective structures like dust devils or storms, grain stratification (or charge separation) occurs giving rise to an overall electric dipole moment to the aeolian feature, similar in nature to the dipolar electric field generated in terrestrial thunderstorms. Previous simulation studies [1] indicate that this storm electric field on Mars can approach atmospheric breakdown field strength of 20 kV/m. In terrestrial dust devils, coherent dipolar electric fields exceeding 20 kV/m have been measured directly via electric field instrumentation. Given the expected electrostatic fields in Martian dust devils and storms, electrons in the low pressure CO2 gas can be energized via the electric field to values exceeding the electron dissociative attachment energy of both CO2 and H2O, resulting in the formation of new chemical products CO and O- and OH and H- within the storm. Using a collisional plasma physics model we present a calculation of the CO/O- and OH/H- reaction and production rates. We demonstrate that these rates vary geometrically with ambient electric field, with substantial production of dissociative products when fields approach breakdown levels of 20-30 kV/m.

  10. In-situ electric field in human body model in different postures for wireless power transfer system in an electrical vehicle.

    PubMed

    Shimamoto, Takuya; Laakso, Ilkka; Hirata, Akimasa

    2015-01-07

    The in-situ electric field of an adult male model in different postures is evaluated for exposure to the magnetic field leaked from a wireless power transfer system in an electrical vehicle. The transfer system is located below the centre of the vehicle body and the transferred power and frequency are 7 kW and 85 kHz, respectively. The in-situ electric field is evaluated for a human model (i) crouching near the vehicle, (ii) lying on the ground with or without his arm stretched, (iii) sitting in the driver's seat, and (iv) standing on a transmitting coil without a receiving coil. In each scenario, the maximum in-situ electric fields are lower than the allowable limit prescribed by international guidelines, although the local magnetic field strength in regions of the human body is higher than the allowable external magnetic field strength. The highest in-situ electric field is observed when the human body model is placed on the ground with his arm extended toward the coils, because of a higher magnetic field around the arm.

  11. RESIDENTIAL EXPOSURE TO EXTREMELY LOW FREQUENCY ELECTRIC AND MAGNETIC FIELDS IN THE CITY OF RAMALLAH-PALESTINE.

    PubMed

    Abuasbi, Falastine; Lahham, Adnan; Abdel-Raziq, Issam Rashid

    2018-04-01

    This study was focused on the measurement of residential exposure to power frequency (50-Hz) electric and magnetic fields in the city of Ramallah-Palestine. A group of 32 semi-randomly selected residences distributed amongst the city were under investigations of fields variations. Measurements were performed with the Spectrum Analyzer NF-5035 and were carried out at one meter above ground level in the residence's bedroom or living room under both zero and normal-power conditions. Fields' variations were recorded over 6-min and some times over few hours. Electric fields under normal-power use were relatively low; ~59% of residences experienced mean electric fields <10 V/m. The highest mean electric field of 66.9 V/m was found at residence R27. However, electric field values were log-normally distributed with geometric mean and geometric standard deviation of 9.6 and 3.5 V/m, respectively. Background electric fields measured under zero-power use, were very low; ~80% of residences experienced background electric fields <1 V/m. Under normal-power use, the highest mean magnetic field (0.45 μT) was found at residence R26 where an indoor power substation exists. However, ~81% of residences experienced mean magnetic fields <0.1 μT. Magnetic fields measured inside the 32 residences showed also a log-normal distribution with geometric mean and geometric standard deviation of 0.04 and 3.14 μT, respectively. Under zero-power conditions, ~7% of residences experienced average background magnetic field >0.1 μT. Fields from appliances showed a maximum mean electric field of 67.4 V/m from hair dryer, and maximum mean magnetic field of 13.7 μT from microwave oven. However, no single result surpassed the ICNIRP limits for general public exposures to ELF fields, but still, the interval 0.3-0.4 μT for possible non-thermal health impacts of exposure to ELF magnetic fields, was experienced in 13% of the residences.

  12. Electrorotation of a metal sphere immersed in an electrolyte of finite Debye length.

    PubMed

    García-Sánchez, Pablo; Ramos, Antonio

    2015-11-01

    We theoretically study the rotation induced on a metal sphere immersed in an electrolyte and subjected to a rotating electric field. The rotation arises from the interaction of the field with the electric charges induced at the metal-electrolyte interface, i.e., the induced electrical double layer (EDL). Particle rotation is due to the torque on the induced dipole, and also from induced-charge electro-osmostic flow (ICEO). The interaction of the electric field with the induced dipole on the system gives rise to counterfield rotation, i.e., the direction opposite to the rotation of the electric field. ICEO generates co-field rotation of the sphere. For thin EDL, ICEO generates negligible rotation. For increasing size of EDL, co-field rotation appears and, in the limit of very thick EDL, it compensates the counter-field rotation induced by the electrical torque. We also report computations of the rotating fluid velocity field around the sphere.

  13. Consistency restrictions on maximal electric-field strength in quantum field theory.

    PubMed

    Gavrilov, S P; Gitman, D M

    2008-09-26

    Quantum field theory with an external background can be considered as a consistent model only if backreaction is relatively small with respect to the background. To find the corresponding consistency restrictions on an external electric field and its duration in QED and QCD, we analyze the mean-energy density of quantized fields for an arbitrary constant electric field E, acting during a large but finite time T. Using the corresponding asymptotics with respect to the dimensionless parameter eET2, one can see that the leading contributions to the energy are due to the creation of particles by the electric field. Assuming that these contributions are small in comparison with the energy density of the electric background, we establish the above-mentioned restrictions, which determine, in fact, the time scales from above of depletion of an electric field due to the backreaction.

  14. A percolation approach to study the high electric field effect on electrical conductivity of insulating polymer

    NASA Astrophysics Data System (ADS)

    Benallou, Amina; Hadri, Baghdad; Martinez-Vega, Juan; El Islam Boukortt, Nour

    2018-04-01

    The effect of percolation threshold on the behaviour of electrical conductivity at high electric field of insulating polymers has been briefly investigated in literature. Sometimes the dead ends links are not taken into account in the study of the electric field effect on the electrical properties. In this work, we present a theoretical framework and Monte Carlo simulation of the behaviour of the electric conductivity at high electric field based on the percolation theory using the traps energies levels which are distributed according to distribution law (uniform, Gaussian, and power-law). When a solid insulating material is subjected to a high electric field, and during trapping mechanism the dead ends of traps affect with decreasing the electric conductivity according to the traps energies levels, the correlation length of the clusters, the length of the dead ends, and the concentration of the accessible positions for the electrons. A reasonably good agreement is obtained between simulation results and the theoretical framework.

  15. Contribution of storm time substorms to the prompt electric field disturbances in the equatorial ionosphere

    DOE PAGES

    Hui, Debrup; Chakrabarty, D.; Sekar, R.; ...

    2017-05-08

    This study tries to bring out the fact that storm time substorms can compete and at times significantly contribute to the geomagnetically disturbed time prompt penetration electric field effects on low and equatorial latitudes. Observations of unusual equatorial plasma drift data from Jicamarca Unattended Long-term Investigations of the Ionosphere and Atmosphere during two space weather events show that substorms can induce both eastward and westward penetration electric fields under steady southward interplanetary magnetic field (IMF B z) conditions. During the first event on 2 January 2005, the enhancement of the daytime eastward electric field over Jicamarca due to substorm ismore » found to be comparable with the Sq and interplanetary electric field (IEFy) generated electric fields combined. During the second event on 19 August 2006, the substorm is seen to weaken the daytime eastward field thereby inducing a westward field in spite of the absence of northward turning of IMF B z (overshielding). The westward electric field perturbation in the absence of any overshielding events is observationally sparse and contrary to the earlier results. Further, the substorm-induced field is found to be strong enough to compete or almost nullify the effects of storm time IEFy fields. This study also shows quantitatively that at times substorm contribution to the disturbed time prompt electric fields can be significant and thus should be taken into consideration in evaluating penetration events over low latitudes.« less

  16. Contribution of storm time substorms to the prompt electric field disturbances in the equatorial ionosphere

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hui, Debrup; Chakrabarty, D.; Sekar, R.

    This study tries to bring out the fact that storm time substorms can compete and at times significantly contribute to the geomagnetically disturbed time prompt penetration electric field effects on low and equatorial latitudes. Observations of unusual equatorial plasma drift data from Jicamarca Unattended Long-term Investigations of the Ionosphere and Atmosphere during two space weather events show that substorms can induce both eastward and westward penetration electric fields under steady southward interplanetary magnetic field (IMF B z) conditions. During the first event on 2 January 2005, the enhancement of the daytime eastward electric field over Jicamarca due to substorm ismore » found to be comparable with the Sq and interplanetary electric field (IEFy) generated electric fields combined. During the second event on 19 August 2006, the substorm is seen to weaken the daytime eastward field thereby inducing a westward field in spite of the absence of northward turning of IMF B z (overshielding). The westward electric field perturbation in the absence of any overshielding events is observationally sparse and contrary to the earlier results. Further, the substorm-induced field is found to be strong enough to compete or almost nullify the effects of storm time IEFy fields. This study also shows quantitatively that at times substorm contribution to the disturbed time prompt electric fields can be significant and thus should be taken into consideration in evaluating penetration events over low latitudes.« less

  17. Relationship Between the Global Electric Circuit and Electrified Cloud Parameters at Diurnal, Seasonal and Interannual Timescales

    NASA Astrophysics Data System (ADS)

    Lavigne, Thomas

    In the early 1900's, J.W. Whipple began validating C.R. Wilson's Global Electric Circuit (GEC) hypothesis by correlating diurnal variations of global thunder days with diurnal variations of the fair weather electric field. This study applies 16+ years of Precipitation Feature (PF) data from the Tropical Rainfall Measuring Mission (TRMM), including lightning data from the Lightning Imaging Sensor (LIS), alongside 12-years of electric field measurements from Vostok, Antarctica to further examine this relationship. Joint diurnal-seasonal variations of the electric field are compared with PF parameters that are potentially related to the GEC. The flash rate and volume of 30 dBZ between -5°C and -35°C variables are shown to have the best direct relationship to the electric field, with r2 values of 0.67 and 0.62, respectively. However, the Coefficient of Variation (COV) of the flash rate (28%) and the electric field (12%), display relatively large differences in the spread of the variables. The volume of 30 dBZ between -5°C and -35°C shows a closer amplitude agreement to the variance of the electric field (COV=17%). Furthermore, these relationships are analyzed during two different phases of the El Nino Southern Oscillation (ENSO). Results show different seasonal-diurnal variations of the electric field during ENSO phases, with enhancements in the electric field between January through April at 16-24 UTC in La Nina years. In all, similar variations have been found in the fair weather electric field, and the variation of properties of global PFs with high potential of electrification at diurnal, seasonal, and interannual timescales. These confirm the dominant role of the global thunderclouds and electrified clouds in the global electric circuit.

  18. Electronic Properties of SiNTs Under External Electric and Magnetic Fields Using the Tight-Binding Method

    NASA Astrophysics Data System (ADS)

    Chegel, Raad; Behzad, Somayeh

    2014-02-01

    We investigated the electronic properties of silicon nanotubes (SiNTs) under external transverse electric fields and axial magnetic fields using the tight-binding approximation. It was found that, after switching on the electric and magnetic fields, band modifications such as distortion of degeneracy, change in energy dispersion and subband spacing, and bandgap size reduction occur. The bandgap of silicon gear-like nanotubes (Si g-NTs) decreases linearly with increasing electric field strength, but the bandgap for silicon hexagonal nanotubes (Si h-NTs) first increases and then decreases (metallic) or first remains constant and then decreases (semiconducting). Our results show that the bandgap of Si h-NTs is very sensitive to both electric and magnetic fields, unlike Si g-NTs, which are more sensitive to electric than magnetic fields.

  19. High-frequency electric field measurement using a toroidal antenna

    DOEpatents

    Lee, Ki Ha

    2002-01-01

    A simple and compact method and apparatus for detecting high frequency electric fields, particularly in the frequency range of 1 MHz to 100 MHz, uses a compact toroidal antenna. For typical geophysical applications the sensor will be used to detect electric fields for a wide range of spectrum starting from about 1 MHz, in particular in the frequency range between 1 to 100 MHz, to detect small objects in the upper few meters of the ground. Time-varying magnetic fields associated with time-varying electric fields induce an emf (voltage) in a toroidal coil. The electric field at the center of (and perpendicular to the plane of) the toroid is shown to be linearly related to this induced voltage. By measuring the voltage across a toroidal coil one can easily and accurately determine the electric field.

  20. Vector electric field measurement via position-modulated Kelvin probe force microscopy

    NASA Astrophysics Data System (ADS)

    Dwyer, Ryan P.; Smieska, Louisa M.; Tirmzi, Ali Moeed; Marohn, John A.

    2017-10-01

    High-quality spatially resolved measurements of electric fields are critical to understanding charge injection, charge transport, and charge trapping in semiconducting materials. Here, we report a variation of frequency-modulated Kelvin probe force microscopy that enables spatially resolved measurements of the electric field. We measure electric field components along multiple directions simultaneously by employing position modulation and lock-in detection in addition to numeric differentiation of the surface potential. We demonstrate the technique by recording linescans of the in-plane electric field vector in the vicinity of a patch of trapped charge in a 2,7-diphenyl[1]benzothieno[3,2-b][1]benzothiophene (DPh-BTBT) organic field-effect transistor. This technique is simple to implement and should be especially useful for studying electric fields in spatially inhomogeneous samples like organic transistors and photovoltaic blends.

  1. Externally applied electric fields up to 1.6 × 10(5) V/m do not affect the homogeneous nucleation of ice in supercooled water.

    PubMed

    Stan, Claudiu A; Tang, Sindy K Y; Bishop, Kyle J M; Whitesides, George M

    2011-02-10

    The freezing of water can initiate at electrically conducting electrodes kept at a high electric potential or at charged electrically insulating surfaces. The microscopic mechanisms of these phenomena are unknown, but they must involve interactions between water molecules and electric fields. This paper investigates the effect of uniform electric fields on the homogeneous nucleation of ice in supercooled water. Electric fields were applied across drops of water immersed in a perfluorinated liquid using a parallel-plate capacitor; the drops traveled in a microchannel and were supercooled until they froze due to the homogeneous nucleation of ice. The distribution of freezing temperatures of drops depended on the rate of nucleation of ice, and the sensitivity of measurements allowed detection of changes by a factor of 1.5 in the rate of nucleation. Sinusoidal alternation of the electric field at frequencies from 3 to 100 kHz prevented free ions present in water from screening the electric field in the bulk of drops. Uniform electric fields in water with amplitudes up to (1.6 ± 0.4) × 10(5) V/m neither enhanced nor suppressed the homogeneous nucleation of ice. Estimations based on thermodynamic models suggest that fields in the range of 10(7)-10(8) V/m might cause an observable increase in the rate of nucleation.

  2. Methodology for Time-Domain Estimation of Storm-Time Electric Fields Using the 3D Earth Impedance

    NASA Astrophysics Data System (ADS)

    Kelbert, A.; Balch, C. C.; Pulkkinen, A. A.; Egbert, G. D.; Love, J. J.; Rigler, E. J.; Fujii, I.

    2016-12-01

    Magnetic storms can induce geoelectric fields in the Earth's electrically conducting interior, interfering with the operations of electric-power grid industry. The ability to estimate these electric fields at Earth's surface in close to real-time and to provide local short-term predictions would improve the ability of the industry to protect their operations. At any given time, the electric field at the Earth's surface is a function of the time-variant magnetic activity (driven by the solar wind), and the local electrical conductivity structure of the Earth's crust and mantle. For this reason, implementation of an operational electric field estimation service requires an interdisciplinary, collaborative effort between space science, real-time space weather operations, and solid Earth geophysics. We highlight in this talk an ongoing collaboration between USGS, NOAA, NASA, Oregon State University, and the Japan Meteorological Agency, to develop algorithms that can be used for scenario analyses and which might be implemented in a real-time, operational setting. We discuss the development of a time domain algorithm that employs discrete time domain representation of the impedance tensor for a realistic 3D Earth, known as the discrete time impulse response (DTIR), convolved with the local magnetic field time series, to estimate the local electric field disturbances. The algorithm is validated against measured storm-time electric field data collected in the United States and Japan. We also discuss our plans for operational real-time electric field estimation using 3D Earth impedances.

  3. Signals of ENPEMF Used in Earthquake Prediction

    NASA Astrophysics Data System (ADS)

    Hao, G.; Dong, H.; Zeng, Z.; Wu, G.; Zabrodin, S. M.

    2012-12-01

    The signals of Earth's natural pulse electromagnetic field (ENPEMF) is a combination of the abnormal crustal magnetic field pulse affected by the earthquake, the induced field of earth's endogenous magnetic field, the induced magnetic field of the exogenous variation magnetic field, geomagnetic pulsation disturbance and other energy coupling process between sun and earth. As an instantaneous disturbance of the variation field of natural geomagnetism, ENPEMF can be used to predict earthquakes. This theory was introduced by A.A Vorobyov, who expressed a hypothesis that pulses can arise not only in the atmosphere but within the Earth's crust due to processes of tectonic-to-electric energy conversion (Vorobyov, 1970; Vorobyov, 1979). The global field time scale of ENPEMF signals has specific stability. Although the wave curves may not overlap completely at different regions, the smoothed diurnal ENPEMF patterns always exhibit the same trend per month. The feature is a good reference for observing the abnormalities of the Earth's natural magnetic field in a specific region. The frequencies of the ENPEMF signals generally locate in kilo Hz range, where frequencies within 5-25 kilo Hz range can be applied to monitor earthquakes. In Wuhan, the best observation frequency is 14.5 kilo Hz. Two special devices are placed in accordance with the S-N and W-E direction. Dramatic variation from the comparison between the pulses waveform obtained from the instruments and the normal reference envelope diagram should indicate high possibility of earthquake. The proposed detection method of earthquake based on ENPEMF can improve the geodynamic monitoring effect and can enrich earthquake prediction methods. We suggest the prospective further researches are about on the exact sources composition of ENPEMF signals, the distinction between noise and useful signals, and the effect of the Earth's gravity tide and solid tidal wave. This method may also provide a promising application in mineral deposits detecting, surface relics pipeline surveying and safety resonance monitoring on reservoir dam.

  4. Electrical stimulation: a novel tool for tissue engineering.

    PubMed

    Balint, Richard; Cassidy, Nigel J; Cartmell, Sarah H

    2013-02-01

    New advances in tissue engineering are being made through the application of different types of electrical stimuli to influence cell proliferation and differentiation. Developments made in the last decade have allowed us to improve the structure and functionality of tissue-engineered products through the use of growth factors, hormones, drugs, physical stimuli, bioreactor use, and two-dimensional (2-D) and three-dimensional (3-D) artificial extracellular matrices (with various material properties and topography). Another potential type of stimulus is electricity, which is important in the physiology and development of the majority of all human tissues. Despite its great potential, its role in tissue regeneration and its ability to influence cell migration, orientation, proliferation, and differentiation has rarely been considered in tissue engineering. This review highlights the importance of endogenous electrical stimulation, gathering the current knowledge on its natural occurrence and role in vivo, discussing the novel methods of delivering this stimulus and examining its cellular and tissue level effects, while evaluating how the technique could benefit the tissue engineering discipline in the future.

  5. Electric field generated by longitudinal axial microtubule vibration modes with high spatial resolution microtubule model

    NASA Astrophysics Data System (ADS)

    Cifra, M.; Havelka, D.; Deriu, M. A.

    2011-12-01

    Microtubules are electrically polar structures fulfilling prerequisites for generation of oscillatory electric field in the kHz to GHz region. Energy supply for excitation of elasto-electrical vibrations in microtubules may be provided from GTP-hydrolysis; motor protein-microtubule interactions; and energy efflux from mitochondria. It recently was determined from anisotropic elastic network modeling of entire microtubules that the frequencies of microtubule longitudinal axial eigenmodes lie in the region of tens of GHz for the physiologically common microtubule lengths. We calculated electric field generated by axial longitudinal vibration modes of microtubule, which model is based on subnanometer precision of charge distribution. Due to elastoelectric nature of the vibrations, the vibration wavelength is million-fold shorter than that of the electromagnetic field in free space and the electric field around the microtubule manifests rich spatial structure with multiple minima. The dielectrophoretic force exerted by electric field on the surrounding molecules will influence the kinetics of reactions via change in the probability of the transport of charge and mass particles. The electric field generated by vibrations of electrically polar cellular structures is expected to play a role in biological self-organization.

  6. Separation of Electric Fields Into Potential and Inductive Parts, and Implications for Radial Diffusion

    NASA Astrophysics Data System (ADS)

    Chan, A. A.; Ilie, R.; Elkington, S. R.; Albert, J.; Huie, W.

    2017-12-01

    It has been traditional to separate radiation belt radial-diffusion coefficients into two contributions: an "electrostatic" diffusion coefficient, which is assumed to be due to a potential (non-inductive) electric field, and an "electromagnetic" diffusion coefficient , which is assumed to be due to the combined effect of an inductive electric field and the corresponding time-dependent magnetic field. One difficulty in implementing this separation when using magnetospheric fields obtained from measurements, or from MHD simulations, is that only the total electric field is given; the separation of the electric field into potential and inductive parts is not readily available. In this work we separate the electric field using a numerical method based on the Helmholtz decomposition of the total motional electric field calculated by the BATS-R-US MHD code. The inner boundary for the electric potential is based on the Ridley Ionospheric Model solution and we assume floating boundary conditions in the solar wind. Using different idealized solar wind drivers, including a solar wind density that is oscillating at a single frequency or with a broad spectrum of frequencies, we calculate potential and inductive electric fields, electric and magnetic power spectral densities, and corresponding radial diffusion coefficients. Simulations driven by idealized solar wind conditions show a clear separation of the potential and inductive contributions to the power spectral densities and diffusion coefficients. Simulations with more realistic solar wind drivers are underway to better assess the use of electrostatic and electromagnetic diffusion coefficients in understanding ULF wave-particle interactions in Earth's radiation belts.

  7. Process development and exergy cost sensitivity analysis of a hybrid molten carbonate fuel cell power plant and carbon dioxide capturing process

    NASA Astrophysics Data System (ADS)

    Mehrpooya, Mehdi; Ansarinasab, Hojat; Moftakhari Sharifzadeh, Mohammad Mehdi; Rosen, Marc A.

    2017-10-01

    An integrated power plant with a net electrical power output of 3.71 × 105 kW is developed and investigated. The electrical efficiency of the process is found to be 60.1%. The process includes three main sub-systems: molten carbonate fuel cell system, heat recovery section and cryogenic carbon dioxide capturing process. Conventional and advanced exergoeconomic methods are used for analyzing the process. Advanced exergoeconomic analysis is a comprehensive evaluation tool which combines an exergetic approach with economic analysis procedures. With this method, investment and exergy destruction costs of the process components are divided into endogenous/exogenous and avoidable/unavoidable parts. Results of the conventional exergoeconomic analyses demonstrate that the combustion chamber has the largest exergy destruction rate (182 MW) and cost rate (13,100 /h). Also, the total process cost rate can be decreased by reducing the cost rate of the fuel cell and improving the efficiency of the combustion chamber and heat recovery steam generator. Based on the total avoidable endogenous cost rate, the priority for modification is the heat recovery steam generator, a compressor and a turbine of the power plant, in rank order. A sensitivity analysis is done to investigate the exergoeconomic factor parameters through changing the effective parameter variations.

  8. Porous stabilized beds, methods of manufacture thereof and articles comprising the same

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Klausner, James F.; Mei, Renwei; Momen, Ayyoub Mehdizadeh

    Disclosed herein is a method comprising disposing a first particle in a reactor; the first particle being a magnetic particle or a particle that can be influenced by a magnetic field, an electric field or a combination of an electrical field and a magnetic field; fluidizing the first particle in the reactor; applying a uniform magnetic field, a uniform electrical field or a combination of a uniform magnetic field and a uniform electrical field to the reactor; elevating the temperature of the reactor; and fusing the first particles to form a monolithic solid.

  9. One-dimensional nonlinear instability study of a slightly viscoelastic, perfectly conducting liquid jet under a radial electric field

    NASA Astrophysics Data System (ADS)

    Li, Fang; Yin, Xie-Yuan; Yin, Xie-Zhen

    2016-05-01

    A one-dimensional electrified viscoelastic model is built to study the nonlinear behavior of a slightly viscoelastic, perfectly conducting liquid jet under a radial electric field. The equations are solved numerically using an implicit finite difference scheme together with a boundary element method. The electrified viscoelastic jet is found to evolve into a beads-on-string structure in the presence of the radial electric field. Although the radial electric field greatly enhances the linear instability of the jet, its influence on the decay of the filament thickness is limited during the nonlinear evolution of the jet. On the other hand, the radial electric field induces axial non-uniformity of the first normal stress difference within the filament. The first normal stress difference in the center region of the filament may be greatly decreased by the radial electric field. The regions with/without satellite droplets are illuminated on the χ (the electrical Bond number)-k (the dimensionless wave number) plane. Satellite droplets may be formed for larger wave numbers at larger radial electric fields.

  10. Interaction of excitable waves emitted from two defects by pulsed electric fields

    NASA Astrophysics Data System (ADS)

    Chen, Jiang-Xing; Zhang, Han; Qiao, Li-Yan; Liang, Hong; Sun, Wei-Gang

    2018-01-01

    In response to a pulsed electric field, spatial distributed heterogeneities in excitable media can serve as nucleation sites for the generation of intramural electrical waves, a phenomenon called as ;wave emission from heterogeneities; (WEH effect). Heterogeneities in cardiac tissue strongly influence each other in the WEH effect. We study the WEH effect in a medium possessing two defects. The role of two defects and their interaction by pulsed DC electric fields (DEF) and rotating electric fields (REF) are investigated. The direction of the applied electric field plays a major role not only in the minimum electrical field necessary to originate wave propagation, but also in the degree of influences of nearby defects. The distance between two defects, i.e. the density of defects, also play an important role in the WEH effect. Generally, the REF is better than the DEF when pulsed electric fields are applied. These results may contribute to the improved application of WEH, especially in older patients with fibrosis and scarring, which are accompanied by a higher incidence of conductivity discontinuities.

  11. Formation of Organized Protein Thin Films with External Electric Field.

    PubMed

    Ferreira, Cecília Fabiana da G; Camargo, Paulo C; Benelli, Elaine M

    2015-10-01

    The effect of an external electric field on the formation of protein GlnB-Hs films and on its buffer solution on siliconized glass slides has been analyzed by current versus electric field curves and atomic force microscopy (AFM). The Herbaspirillum seropedicae GlnB protein (GlnB-Hs) is a globular, soluble homotrimer (36 kDa) with its 3-D structure previously determined. Concentrations of 10 nM native denatured GlnB-Hs protein were deposited on siliconized glass slides under ambient conditions. Immediately after solution deposition a maximum electric field of 30 kV/m was applied with rates of 3 V/s. The measured currents were surface currents and were analyzed as transport current. Electric current started to flow only after a minimum electric field (critical value) for the systems analyzed. The AFM images showed films with a high degree of directional organization only when the proteins were present in the solution. These results showed that the applied electric field favored directional organization of the protein GlnB-Hs films and may contribute to understand the formation of protein films under applied electric fields.

  12. Evaluation of DC electric field distribution of PPLP specimen based on the measurement of electrical conductivity in LN2

    NASA Astrophysics Data System (ADS)

    Hwang, Jae-Sang; Seong, Jae-Kyu; Shin, Woo-Ju; Lee, Jong-Geon; Cho, Jeon-Wook; Ryoo, Hee-Suk; Lee, Bang-Wook

    2013-11-01

    High temperature superconducting (HTS) cable has been paid much attention due to its high efficiency and high current transportation capability, and it is also regarded as eco-friendly power cable for the next generation. Especially for DC HTS cable, it has more sustainable and stable properties compared to AC HTS cable due to the absence of AC loss in DC HTS cable. Recently, DC HTS cable has been investigated competitively all over the world, and one of the key components of DC HTS cable to be developed is a cable joint box considering HVDC environment. In order to achieve the optimum insulation design of the joint box, analysis of DC electric field distribution of the joint box is a fundamental process to develop DC HTS cable. Generally, AC electric field distribution depends on relative permittivity of dielectric materials but in case of DC, electrical conductivity of dielectric material is a dominant factor which determines electric field distribution. In this study, in order to evaluate DC electric field characteristics of the joint box for DC HTS cable, polypropylene laminated paper (PPLP) specimen has been prepared and its DC electric field distribution was analyzed based on the measurement of electrical conductivity of PPLP in liquid nitrogen (LN2). Electrical conductivity of PPLP in LN2 has not been reported yet but it should be measured for DC electric field analysis. The experimental works for measuring electrical conductivity of PPLP in LN2 were presented in this paper. Based on the experimental works, DC electric field distribution of PPLP specimen was fully analyzed considering the steady state and the transient state of DC. Consequently, it was possible to determine the electric field distribution characteristics considering different DC applying stages including DC switching on, DC switching off and polarity reversal conditions.

  13. Analysis of DE-1 PWI electric field data

    NASA Technical Reports Server (NTRS)

    Weimer, Daniel

    1994-01-01

    The measurement of low frequency electric field oscillations may be accomplished with the Plasma Wave Instrument (PWI) on DE 1. Oscillations at a frequency around 1 Hz are below the range of the conventional plasma wave receivers, but they can be detected by using a special processing of the quasi-static electric field data. With this processing it is also possible to determine if the electric field oscillations are predominately parallel or perpendicular to the ambient magnetic field. The quasi-static electric field in the DE 1 spin/orbit plane is measured with a long-wire 'double probe'. This antenna is perpendicular to the satellite spin axis, which in turn is approximately perpendicular to the geomagnetic field in the polar magnetosphere. The electric field data are digitally sampled at a frequency of 16 Hz. The measured electric field signal, which has had phase reversals introduced by the rotating antenna, is multiplied by the sine of the rotation angle between the antenna and the magnetic field. This is called the 'perpendicular' signal. The measured time series is also multiplied with the cosine of the angle to produce a separate 'parallel' signal. These two separate time series are then processed to determine the frequency power spectrum.

  14. Electric field measurements in a near atmospheric pressure nanosecond pulse discharge with picosecond electric field induced second harmonic generation

    NASA Astrophysics Data System (ADS)

    Goldberg, Benjamin M.; Chng, Tat Loon; Dogariu, Arthur; Miles, Richard B.

    2018-02-01

    We present an optical electric field measurement method for use in high pressure plasma discharges. The method is based upon the field induced second harmonic generation technique and can be used for localized electric field measurements with sub-nanosecond resolution in any gaseous species. When an external electric field is present, a dipole is induced in the typically centrosymmetric medium, allowing for second harmonic generation with signal intensities which scale by the square of the electric field. Calibrations have been carried out in 100 Torr room air, and a minimum sensitivity of 450 V/cm is demonstrated. Measurements were performed with nanosecond or faster temporal resolution in a 100 Torr room air environment both with and without a plasma present. It was shown that with no plasma present, the field follows the applied voltage to gap ratio, as measured using the back current shunt method. When the electric field is strong enough to exceed the breakdown threshold, the measured field was shown to exceed the anticipated voltage to gap ratio which is taken as an indication of the ionization wave front as it sweeps through the plasma volume.

  15. Steering Electromagnetic Fields in MRI: Investigating Radiofrequency Field Interactions with Endogenous and External Dielectric Materials for Improved Coil Performance at High Field

    NASA Astrophysics Data System (ADS)

    Vaidya, Manushka

    Although 1.5 and 3 Tesla (T) magnetic resonance (MR) systems remain the clinical standard, the number of 7 T MR systems has increased over the past decade because of the promise of higher signal-to-noise ratio (SNR), which can translate to images with higher resolution, improved image quality and faster acquisition times. However, there are a number of technical challenges that have prevented exploiting the full potential of ultra-high field (≥ 7 T) MR imaging (MRI), such as the inhomogeneous distribution of the radiofrequency (RF) electromagnetic field and specific energy absorption rate (SAR), which can compromise image quality and patient safety. To better understand the origin of these issues, we first investigated the dependence of the spatial distribution of the magnetic field associated with a surface RF coil on the operating frequency and electrical properties of the sample. Our results demonstrated that the asymmetries between the transmit (B1+) and receive (B 1-) circularly polarized components of the magnetic field, which are in part responsible for RF inhomogeneity, depend on the electric conductivity of the sample. On the other hand, when sample conductivity is low, a high relative permittivity can result in an inhomogeneous RF field distribution, due to significant constructive and destructive interference patterns between forward and reflected propagating magnetic field within the sample. We then investigated the use of high permittivity materials (HPMs) as a method to alter the field distribution and improve transmit and receive coil performance in MRI. We showed that HPM placed at a distance from an RF loop coil can passively shape the field within the sample. Our results showed improvement in transmit and receive sensitivity overlap, extension of coil field-of-view, and enhancement in transmit/receive efficiency. We demonstrated the utility of this concept by employing HPM to improve performance of an existing commercial head coil for the inferior regions of the brain, where the specific coil's imaging efficiency was inherently poor. Results showed a gain in SNR, while the maximum local and head SAR values remained below the prescribed limits. We showed that increasing coil performance with HPM could improve detection of functional MR activation during a motor-based task for whole brain fMRI. Finally, to gain an intuitive understanding of how HPM improves coil performance, we investigated how HPM separately affects signal and noise sensitivity to improve SNR. For this purpose, we employed a theoretical model based on dyadic Green's functions to compare the characteristics of current patterns, i.e. the optimal spatial distribution of coil conductors, that would either maximize SNR (ideal current patterns), maximize signal reception (signal-only optimal current patterns), or minimize sample noise (dark mode current patterns). Our results demonstrated that the presence of a lossless HPM changed the relative balance of signal-only optimal and dark mode current patterns. For a given relative permittivity, increasing the thickness of the HPM altered the magnitude of the currents required to optimize signal sensitivity at the voxel of interest as well as decreased the net electric field in the sample, which is associated, via reciprocity, to the noise received from the sample. Our results also suggested that signal-only current patterns could be used to identify HPM configurations that lead to high SNR gain for RF coil arrays. We anticipate that physical insights from this work could be utilized to build the next generation of high performing RF coils integrated with HPM.

  16. Method of sustaining a radial electric field and poloidal plasma rotation over most of the cross-section of a tokamak

    DOEpatents

    Darrow, Douglass S.; Ono, Masayuki

    1990-03-06

    A radial electric field of a desired magnitude and configuration is created throughout a substantial portion of the cross-section of the plasma of a tokamak. The radial electric field is created by injection of a unidirectional electron beam. The magnitude and configuration of the radial electric field may be controlled by the strength of the toroidal magnetic field of the tokamak.

  17. Method of sustaining a radial electric field and poloidal plasma rotation over most of the cross-section of a tokamak

    DOEpatents

    Darrow, Douglass S.; Ono, Masayuki

    1990-01-01

    A radial electric field of a desired magnitude and configuration is created hroughout a substantial portion of the cross-section of the plasma of a tokamak. The radial electric field is created by injection of a unidirectional electron beam. The magnitude and configuration of the radial electric field may be controlled by the strength of the toroidal magnetic field of the tokamak.

  18. Rotationally Vibrating Electric-Field Mill

    NASA Technical Reports Server (NTRS)

    Kirkham, Harold

    2008-01-01

    A proposed instrument for measuring a static electric field would be based partly on a conventional rotating-split-cylinder or rotating-split-sphere electric-field mill. However, the design of the proposed instrument would overcome the difficulty, encountered in conventional rotational field mills, of transferring measurement signals and power via either electrical or fiber-optic rotary couplings that must be aligned and installed in conjunction with rotary bearings. Instead of being made to rotate in one direction at a steady speed as in a conventional rotational field mill, a split-cylinder or split-sphere electrode assembly in the proposed instrument would be set into rotational vibration like that of a metronome. The rotational vibration, synchronized with appropriate rapid electronic switching of electrical connections between electric-current-measuring circuitry and the split-cylinder or split-sphere electrodes, would result in an electrical measurement effect equivalent to that of a conventional rotational field mill. A version of the proposed instrument is described.

  19. Electric Field-Controlled Ion Transport In TiO2 Nanochannel.

    PubMed

    Li, Dan; Jing, Wenheng; Li, Shuaiqiang; Shen, Hao; Xing, Weihong

    2015-06-03

    On the basis of biological ion channels, we constructed TiO2 membranes with rigid channels of 2.3 nm to mimic biomembranes with flexible channels; an external electric field was employed to regulate ion transport in the confined channels at a high ionic strength in the absence of electrical double layer overlap. Results show that transport rates for both Na+ and Mg2+ were decreased irrespective of the direction of the electric field. Furthermore, a voltage-gated selective ion channel was formed, the Mg2+ channel closed at -2 V, and a reversed relative electric field gradient was at the same order of the concentration gradient, whereas the Na+ with smaller Stokes radius and lower valence was less sensitive to the electric field and thus preferentially occupied and passed the channel. Thus, when an external electric field is applied, membranes with larger nanochannels have promising applications in selective separation of mixture salts at a high concentration.

  20. Enhancing Food Processing by Pulsed and High Voltage Electric Fields: Principles and Applications.

    PubMed

    Wang, Qijun; Li, Yifei; Sun, Da-Wen; Zhu, Zhiwei

    2018-02-02

    Improvements in living standards result in a growing demand for food with high quality attributes including freshness, nutrition and safety. However, current industrial processing methods rely on traditional thermal and chemical methods, such as sterilization and solvent extraction, which could induce negative effects on food quality and safety. The electric fields (EFs) involving pulsed electric fields (PEFs) and high voltage electric fields (HVEFs) have been studied and developed for assisting and enhancing various food processes. In this review, the principles and applications of pulsed and high voltage electric fields are described in details for a range of food processes, including microbial inactivation, component extraction, and winemaking, thawing and drying, freezing and enzymatic inactivation. Moreover, the advantages and limitations of electric field related technologies are discussed to foresee future developments in the food industry. This review demonstrates that electric field technology has a great potential to enhance food processing by supplementing or replacing the conventional methods employed in different food manufacturing processes. Successful industrial applications of electric field treatments have been achieved in some areas such as microbial inactivation and extraction. However, investigations of HVEFs are still in an early stage and translating the technology into industrial applications need further research efforts.

  1. Vertical electric field stimulation of neural cells on porous amorphous carbon electrodes

    NASA Astrophysics Data System (ADS)

    Jain, Shilpee; Sharma, Ashutosh; Basu, Bikramjit

    2014-03-01

    We demonstrate the efficacy of amorphous macroporous carbon substrates as electrodes to stimulate neuronal cell proliferation in presence of external electric field. The electric field was applied perpendicular to carbon electrode, while growing mouse neuroblastoma (N2a) cells in vitro. The placement of the second electrode outside of the cell culture medium allows the investigation of cell response to electric field without the concurrent complexities of submerged electrodes such as potentially toxic electrode reactions, electro-kinetic flows and charge transfer (electrical current) in the cell medium. The macroporous carbon electrodes are uniquely characterized by a higher specific charge storage capacity (0.2 mC/cm2) and low impedance (3.3 k Ω at 1 kHz). When a uniform or a gradient electric field was applied perpendicular to the amorphous carbon substrate, it was found that the N2a cell viability and neurite length were higher at low electric field strengths (<= 2.5 V/cm) compared to that measured without an applied field (0 V/cm). Overall, the results of the present study unambiguously establish the uniform/gradient vertical electric field based culture protocol to stimulate neurite outgrowth and viability of nerve cells.

  2. Numerically simulated exposure of children and adults to pulsed gradient fields in MRI.

    PubMed

    Samoudi, Amine M; Vermeeren, Gunter; Tanghe, Emmeric; Van Holen, Roel; Martens, Luc; Josephs, Wout

    2016-11-01

    To determine exposure to gradient switching fields of adults and children in a magnetic resonance imaging (MRI) scanner by evaluating internal electric fields within realistic models of adult male, adult female, and child inside transverse and longitudinal gradient coils, and to compare these results with compliance guidelines. Patients inside x-, y-, and z-gradient coils were simulated using anatomically realistic models of adult male, adult female, and child. The induced electric fields were computed for 1 kHz sinusoidal current with a magnitude of 1 A in the gradient coils. Rheobase electric fields were then calculated and compared to the International Commission on Non-Ionizing Radiation Protection (ICNIRP) 2004 and International Electrotechnical Commission (IEC) 2010 guidelines. The effect of the human body, coil type, and skin conductivity on the induced electric field was also investigated. The internal electric fields are within the first level controlled operating mode of the guidelines and range from 2.7V m -1 to 4.5V m -1 , except for the adult male inside the y-gradient coil (induced field reaches 5.4V m -1 ).The induced electric field is sensitive to the coil type (electric field in the skin of adult male: 4V m -1 , 4.6V m -1 , and 3.8V m -1 for x-, y-, and z-gradient coils, respectively), the human body model (electric field in the skin inside y-gradient coil: 4.6V m -1 , 4.2V m -1 , and 3V m -1 for adult male, adult female, and child, respectively), and the skin conductivity (electric field 2.35-4.29% higher for 0.1S m -1 skin conductivity compared to 0.2S m -1 ). The y-gradient coil induced the largest fields in the patients. The highest levels of internal electric fields occurred for the adult male model. J. Magn. Reson. Imaging 2016;44:1360-1367. © 2016 International Society for Magnetic Resonance in Medicine.

  3. Wireless Open-Circuit In-Plane Strain and Displacement Sensor Requiring No Electrical Connections

    NASA Technical Reports Server (NTRS)

    Woodard, Stanley E. (Inventor)

    2014-01-01

    A wireless in-plane strain and displacement sensor includes an electrical conductor fixedly coupled to a substrate subject to strain conditions. The electrical conductor is shaped between its ends for storage of an electric field and a magnetic field, and remains electrically unconnected to define an unconnected open-circuit having inductance and capacitance. In the presence of a time-varying magnetic field, the electrical conductor so-shaped resonates to generate harmonic electric and magnetic field responses. The sensor also includes at least one electrically unconnected electrode having an end and a free portion extending from the end thereof. The end of each electrode is fixedly coupled to the substrate and the free portion thereof remains unencumbered and spaced apart from a portion of the electrical conductor so-shaped. More specifically, at least some of the free portion is disposed at a location lying within the magnetic field response generated by the electrical conductor. A motion guidance structure is slidingly engaged with each electrode's free portion in order to maintain each free portion parallel to the electrical conductor so-shaped.

  4. Nanosecond liquid crystalline optical modulator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Borshch, Volodymyr; Shiyanovskii, Sergij V.; Lavrentovich, Oleg D.

    2016-07-26

    An optical modulator includes a liquid crystal cell containing liquid crystal material having liquid crystal molecules oriented along a quiescent director direction in the unbiased state, and a voltage source configured to apply an electric field to the liquid crystal material wherein the direction of the applied electric field does not cause the quiescent director direction to change. An optical source is arranged to transmit light through or reflect light off the liquid crystal cell with the light passing through the liquid crystal material at an angle effective to undergo phase retardation in response to the voltage source applying themore » electric field. The liquid crystal material may have negative dielectric anisotropy, and the voltage source configured to apply an electric field to the liquid crystal material whose electric field vector is transverse to the quiescent director direction. Alternatively, the liquid crystal material may have positive dielectric anisotropy and the voltage source configured to apply an electric field to the liquid crystal material whose electric field vector is parallel with the quiescent director direction.« less

  5. Wetting and motion behaviors of water droplet on graphene under thermal-electric coupling field

    NASA Astrophysics Data System (ADS)

    Zhang, Zhong-Qiang; Dong, Xin; Ye, Hong-Fei; Cheng, Guang-Gui; Ding, Jian-Ning; Ling, Zhi-Yong

    2015-02-01

    Wetting dynamics and motion behaviors of a water droplet on graphene are characterized under the electric-thermal coupling field using classical molecular dynamics simulation method. The water droplet on graphene can be driven by the temperature gradient, while the moving direction is dependent on the electric field intensity. Concretely, the water droplet on graphene moves from the low temperature region to the high temperature region for the relatively weak electric field intensity. The motion acceleration increases with the electric field intensity on graphene, whereas the moving direction switches when the electric field intensity increases up to a threshold. The essence is the change from hydrophilic to hydrophobic for the water droplet on graphene at a threshold of the electric field intensity. Moreover, the driven force of the water droplet caused by the overall oscillation of graphene has important influence on the motion behaviors. The results are helpful to control the wettability of graphene and further develop the graphene-based fluidic nanodevices.

  6. Electrically-induced polarization selection rules of a graphene quantum dot

    NASA Astrophysics Data System (ADS)

    Dong, Qing-Rui; Li, Yan; Jia, Chen; Wang, Fu-Li; Zhang, Ya-Ting; Liu, Chun-Xiang

    2018-05-01

    We study theoretically the single-electron triangular zigzag graphene quantum dot in uniform in-plane electric fields. The absorption spectra of the dot are calculated by the tight-binding method. The energy spectra and the distribution of wave functions are also presented to analyse the absorption spectra. The orthogonal zero-energy eigenstates are arranged along to the direction of the external field. The remarkable result is that all intraband transitions and some interband transitions are forbidden when the absorbed light is polarized along the direction of the electric field. With x-direction electric field, all intraband absorption is y polarized due to the electric-field-direction-polarization selection rule. Moreover, with y-direction electric field, all absorption is either x or y polarized due to the parity selection rule as well as to the electric-field-direction-polarization selection rule. Our calculation shows that the formation of the absorption spectra is co-decided by the polarization selection rules and the overlap between the eigenstates of the transition.

  7. Imaging electric field dynamics with graphene optoelectronics

    DOE PAGES

    Horng, Jason; Balch, Halleh B.; McGuire, Allister F.; ...

    2016-12-16

    The use of electric fields for signalling and control in liquids is widespread, spanning bioelectric activity in cells to electrical manipulation of microstructures in lab-on-a-chip devices. However, an appropriate tool to resolve the spatio-temporal distribution of electric fields over a large dynamic range has yet to be developed. Here we present a label-free method to image local electric fields in real time and under ambient conditions. Our technique combines the unique gate-variable optical transitions of graphene with a critically coupled planar waveguide platform that enables highly sensitive detection of local electric fields with a voltage sensitivity of a few microvolts,more » a spatial resolution of tens of micrometres and a frequency response over tens of kilohertz. Our imaging platform enables parallel detection of electric fields over a large field of view and can be tailored to broad applications spanning lab-on-a-chip device engineering to analysis of bioelectric phenomena.« less

  8. Imaging electric field dynamics with graphene optoelectronics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Horng, Jason; Balch, Halleh B.; McGuire, Allister F.

    The use of electric fields for signalling and control in liquids is widespread, spanning bioelectric activity in cells to electrical manipulation of microstructures in lab-on-a-chip devices. However, an appropriate tool to resolve the spatio-temporal distribution of electric fields over a large dynamic range has yet to be developed. Here we present a label-free method to image local electric fields in real time and under ambient conditions. Our technique combines the unique gate-variable optical transitions of graphene with a critically coupled planar waveguide platform that enables highly sensitive detection of local electric fields with a voltage sensitivity of a few microvolts,more » a spatial resolution of tens of micrometres and a frequency response over tens of kilohertz. Our imaging platform enables parallel detection of electric fields over a large field of view and can be tailored to broad applications spanning lab-on-a-chip device engineering to analysis of bioelectric phenomena.« less

  9. Numerical investigation of the effect of net charge injection on the electric field deviation in a TE CO2 laser

    NASA Astrophysics Data System (ADS)

    Jahanianl, Nahid; Aram, Majid; Morshedian, Nader; Mehramiz, Ahmad

    2018-03-01

    In this report, the distribution of and deviation in the electric field were investigated in the active medium of a TE CO2 laser. The variation in the electric field is due to injection of net electron and proton charges as a plasma generator. The charged-particles beam density is assumed to be Gaussian. The electric potential and electric field distribution were simulated by solving Poisson’s equation using the SOR numerical method. The minimum deviation of the electric field obtained was about 2.2% and 6% for the electrons and protons beams, respectively, for a charged-particles beam-density of 106 cm-3. This result was obtained for a system geometry ensuring a mean-free-path of the particles beam of 15 mm. It was also found that the field deviation increases for a the mean-free-path smaller than that or larger than 25 mm. Moreover, the electric field deviation decreases when the electrons beam density exceeds 106 cm-3.

  10. Application of integral equation theory to analyze stability of electric field in multimode microwave heating cavity

    NASA Astrophysics Data System (ADS)

    Tang, Zhengming; Hong, Tao; Chen, Fangyuan; Zhu, Huacheng; Huang, Kama

    2017-10-01

    Microwave heating uniformity is mainly dependent on and affected by electric field. However, little study has paid attention to its stability characteristics in multimode cavity. In this paper, this problem is studied by the theory of Freedholm integral equation. Firstly, Helmholtz equation and the electric dyadic Green's function are used to derive the electric field integral equation. Then, the stability of electric field is demonstrated as the characteristics of solutions to Freedholm integral equation. Finally, the stability characteristics are obtained and verified by finite element calculation. This study not only can provide a comprehensive interpretation of electric field in multimode cavity but also help us make better use of microwave energy.

  11. Soap-film flow induced by electric fields in asymmetric frames

    NASA Astrophysics Data System (ADS)

    Mollaei, S.; Nasiri, M.; Soltanmohammadi, N.; Shirsavar, R.; Ramos, A.; Amjadi, A.

    2018-04-01

    Net fluid flow of soap films induced by (ac or dc) electric fields in asymmetric frames is presented. Previous experiments of controllable soap film flow required the simultaneous use of an electrical current passing through the film and an external electric field or the use of nonuniform ac electric fields. Here a single voltage difference generates both the electrical current going through the film and the electric field that actuates on the charge induced on the film. The film is set into global motion due to the broken symmetry that appears by the use of asymmetric frames. If symmetric frames are used, the film flow is not steady but time dependent and irregular. Finally, we study numerically these film flows by employing the model of charge induction in ohmic liquids.

  12. Soap-film flow induced by electric fields in asymmetric frames.

    PubMed

    Mollaei, S; Nasiri, M; Soltanmohammadi, N; Shirsavar, R; Ramos, A; Amjadi, A

    2018-04-01

    Net fluid flow of soap films induced by (ac or dc) electric fields in asymmetric frames is presented. Previous experiments of controllable soap film flow required the simultaneous use of an electrical current passing through the film and an external electric field or the use of nonuniform ac electric fields. Here a single voltage difference generates both the electrical current going through the film and the electric field that actuates on the charge induced on the film. The film is set into global motion due to the broken symmetry that appears by the use of asymmetric frames. If symmetric frames are used, the film flow is not steady but time dependent and irregular. Finally, we study numerically these film flows by employing the model of charge induction in ohmic liquids.

  13. Stable current outputs and phytate degradation by yeast-based biofuel cell.

    PubMed

    Hubenova, Yolina; Georgiev, Danail; Mitov, Mario

    2014-09-01

    In this paper, we report for the first time that Candida melibiosica 2491 yeast strain expresses enhanced phytase activity when used as a biocatalyst in biofuel cells. The polarization also results in an increase of the yeast biomass. Higher steady-state electrical outputs, assigned to earlier production of an endogenous mediator, were achieved at continuous polarization under constant load. The obtained results prove that the C. melibiosica yeast-based biofuel cell could be used for simultaneous electricity generation and phytate bioremediation. In addition, the higher phytase activity obtained by interruptive polarization suggests a new method for increasing the phytase yield from microorganisms. Copyright © 2014 John Wiley & Sons, Ltd.

  14. Surface area generation and droplet size control in solvent extraction systems utilizing high intensity electric fields

    DOEpatents

    Scott, Timothy C.; Wham, Robert M.

    1988-01-01

    A method and system for solvent extraction where droplets are shattered by a high intensity electric field. These shattered droplets form a plurality of smaller droplets which have a greater combined surface area than the original droplet. Dispersion, coalescence and phase separation are accomplished in one vessel through the use of the single pulsing high intensity electric field. Electric field conditions are chosen so that simultaneous dispersion and coalescence are taking place in the emulsion formed in the electric field. The electric field creates a large amount of interfacial surface area for solvent extraction when the droplet is disintegrated and is capable of controlling droplet size and thus droplet stability. These operations take place in the presence of a counter current flow of the continuous phase.

  15. Controlling the anomalous Hall effect by electric-field-induced piezo-strain in Fe40Pt60/(001)-Pb(Mg1/3Nb2/3)0.67Ti0.33O3 multiferroic heterostructures

    NASA Astrophysics Data System (ADS)

    Yang, Yuanjun; Yao, Yingxue; Chen, Lei; Huang, Haoliang; Zhang, Benjian; Lin, Hui; Luo, Zhenlin; Gao, Chen; Lu, Y. L.; Li, Xiaoguang; Xiao, Gang; Feng, Ce; Zhao, Y. G.

    2018-01-01

    Electric-field control of the anomalous Hall effect (AHE) was investigated in Fe40Pt60/(001)-Pb(Mg1/3Nb2/3)0.67Ti0.33O3 (FePt/PMN-PT) multiferroic heterostructures at room temperature. It was observed that a very large Hall resistivity change of up to 23.9% was produced using electric fields under a magnetic field bias of 100 Oe. A pulsed electric field sequence was used to generate nonvolatile strain to manipulate the Hall resistivity. Two corresponding nonvolatile states with distinct Hall resistivities were achieved after the electric fields were removed, thus enabling the encoding of binary information for memory applications. These results demonstrate that the Hall resistivity can be reversibly switched in a nonvolatile manner using programmable electric fields. Two remanent magnetic states that were created by electric-field-induced piezo-strain from the PMN-PT were attributed to the nonvolatile and reversible properties of the AHE. This work suggests that a low-energy-consumption-based approach can be used to create nonvolatile resistance states for spintronic devices based on electric-field control of the AHE.

  16. Exploring Instructive Physiological Signaling with the Bioelectric Tissue Simulation Engine

    PubMed Central

    Pietak, Alexis; Levin, Michael

    2016-01-01

    Bioelectric cell properties have been revealed as powerful targets for modulating stem cell function, regenerative response, developmental patterning, and tumor reprograming. Spatio-temporal distributions of endogenous resting potential, ion flows, and electric fields are influenced not only by the genome and external signals but also by their own intrinsic dynamics. Ion channels and electrical synapses (gap junctions) both determine, and are themselves gated by, cellular resting potential. Thus, the origin and progression of bioelectric patterns in multicellular tissues is complex, which hampers the rational control of voltage distributions for biomedical interventions. To improve understanding of these dynamics and facilitate the development of bioelectric pattern control strategies, we developed the BioElectric Tissue Simulation Engine (BETSE), a finite volume method multiphysics simulator, which predicts bioelectric patterns and their spatio-temporal dynamics by modeling ion channel and gap junction activity and tracking changes to the fundamental property of ion concentration. We validate performance of the simulator by matching experimentally obtained data on membrane permeability, ion concentration and resting potential to simulated values, and by demonstrating the expected outcomes for a range of well-known cases, such as predicting the correct transmembrane voltage changes for perturbation of single cell membrane states and environmental ion concentrations, in addition to the development of realistic transepithelial potentials and bioelectric wounding signals. In silico experiments reveal factors influencing transmembrane potential are significantly different in gap junction-networked cell clusters with tight junctions, and identify non-linear feedback mechanisms capable of generating strong, emergent, cluster-wide resting potential gradients. The BETSE platform will enable a deep understanding of local and long-range bioelectrical dynamics in tissues, and assist the development of specific interventions to achieve greater control of pattern during morphogenesis and remodeling. PMID:27458581

  17. Electric Potential Across Epidermis and Its Role During Wound Healing Can Be Studied by Using an In Vitro Reconstructed Human Skin

    PubMed Central

    Moulin, Véronique J.; Dubé, Jean; Rochette-Drouin, Olivier; Lévesque, Philippe; Gauvin, Robert; Roberge, Charles J.; Auger, François A.; Goulet, Daniel; Bourdages, Michel; Plante, Michel; Germain, Lucie

    2012-01-01

    Background After human epidermis wounding, transepithelial potential (TEP) present in nonlesional epidermis decreases and induces an endogenous direct current epithelial electric field (EEF) that could be implicated in the wound re-epithelialization. Some studies suggest that exogenous electric stimulation of wounds can stimulate healing, although the mechanisms remain to be determined. The Problem Little is known concerning the exact action of the EEF during healing. The mechanism responsible for TEP and EEF is unknown due to the lack of an in vitro model to study this phenomenon. Basic Science Advances We carried out studies by using a wound created in a human tissue-engineered skin and determined that TEP undergoes ascending and decreasing phases during the epithelium formation. The in vitro TEP measurements over time in the wound were corroborated with histological changes and with in vivo TEP variations during porcine skin wound healing. The expression of a crucial element implicated in Na+ transport, Na+/K+ ATPase pumps, was also evaluated at the same time points during the re-epithelialization process. The ascending and decreasing TEP values were correlated with changes in the expression of these pumps. The distribution of Na+/K+ ATPase pumps also varied according to epidermal differentiation. Further, inhibition of the pump activity induced a significant decrease of the TEP and of the re-epithelization rate. Clinical Care Relevance A better comprehension of the role of EEF could have important future medical applications regarding the treatment of chronic wound healing. Conclusion This study brings a new perspective to understand the formation and restoration of TEP during the cutaneous wound healing process. PMID:24527285

  18. Status-Dependent Vasotocin Modulation of Dominance and Subordination in the Weakly Electric Fish Gymnotus omarorum.

    PubMed

    Perrone, Rossana; Silva, Ana C

    2018-01-01

    Dominant-subordinate status emerges from agonistic encounters. The weakly electric fish, Gymnotus omarorum , displays a clear-cut example of non-breeding territorial aggression. The asymmetry in the behavior of dominants and subordinates is outstanding. Dominants are highly aggressive and subordinates signal submission in a precise sequence of locomotor and electric traits: retreating, decreasing their electric organ discharge rate, and emitting transient electric signals. The hypothalamic neuropeptide arginine-vasotocin (AVT) and its mammalian homolog arginine-vasopressin, are key modulators of social behavior, known to adapt their actions to different contexts. By analyzing the effects of pharmacological manipulations of the AVT system in both dominants and subordinates, we show evidence of distinct status-dependent actions of AVT. We demonstrate an endogenous effect of AVT on dominants' aggression levels: blocking the V1a AVT receptor induced a significant decrease in dominants' attack rate. AVT administered to subordinates enhanced the expression of the electric signals of submission, without affecting subordinates' locomotor displays. This study contributes a clear example of status-dependent AVT modulation of agonistic behavior in teleosts, and reveals distinctive activation patterns of the AVT system between dominants and subordinates.

  19. Effects of the reconnection electric field on crescent electron distribution functions in asymmetric guide field reconnection

    NASA Astrophysics Data System (ADS)

    Bessho, N.; Chen, L. J.; Hesse, M.; Wang, S.

    2017-12-01

    In asymmetric reconnection with a guide field in the Earth's magnetopause, electron motion in the electron diffusion region (EDR) is largely affected by the guide field, the Hall electric field, and the reconnection electric field. The electron motion in the EDR is neither simple gyration around the guide field nor simple meandering motion across the current sheet. The combined meandering motion and gyration has essential effects on particle acceleration by the in-plane Hall electric field (existing only in the magnetospheric side) and the out-of-plane reconnection electric field. We analyze electron motion and crescent-shaped electron distribution functions in the EDR in asymmetric guide field reconnection, and perform 2-D particle-in-cell (PIC) simulations to elucidate the effect of reconnection electric field on electron distribution functions. Recently, we have analytically expressed the acceleration effect due to the reconnection electric field on electron crescent distribution functions in asymmetric reconnection without a guide field (Bessho et al., Phys. Plasmas, 24, 072903, 2017). We extend the theory to asymmetric guide field reconnection, and predict the crescent bulge in distribution functions. Assuming 1D approximation of field variations in the EDR, we derive the time period of oscillatory electron motion (meandering + gyration) in the EDR. The time period is expressed as a hybrid of the meandering period and the gyro period. Due to the guide field, electrons not only oscillate along crescent-shaped trajectories in the velocity plane perpendicular to the antiparallel magnetic fields, but also move along parabolic trajectories in the velocity plane coplanar with magnetic field. The trajectory in the velocity space gradually shifts to the acceleration direction by the reconnection electric field as multiple bounces continue. Due to the guide field, electron distributions for meandering particles are bounded by two paraboloids (or hyperboloids) in the velocity space. We compare theory and PIC simulation results of the velocity shift of crescent distribution functions based on the derived time period of bounce motion in a guide field. Theoretical predictions are applied to electron distributions observed by MMS in magnetopause reconnection to estimate the reconnection electric field.

  20. Step-wise potential development across the lipid bilayer under external electric fields

    NASA Astrophysics Data System (ADS)

    Majhi, Amit Kumar

    2018-04-01

    Pore formation across the bilayers under external electric field is an important phenomenon, which has numerous applications in biology and bio-engineering fields. However, it is not a ubiquitous event under all field applications. To initiate a pore in the bilayer a particular threshold electric field is required. The electric field alters the intrinsic potential distribution across the bilayer as we as it enhances total potential drop across the bilayer, which causes the pore formation. The intrinsic potential profile has a maximum peak value, which is 0.8 V and it gets enhanced under application of external field, 0.43 V/nm. The peak value becomes 1.4 V when a pore appears in the bilayer and it continues to evolve as along as the external electric field remains switched on.

  1. Electric field distribution and current emission in a miniaturized geometrical diode

    NASA Astrophysics Data System (ADS)

    Lin, Jinpu; Wong, Patrick Y.; Yang, Penglu; Lau, Y. Y.; Tang, W.; Zhang, Peng

    2017-06-01

    We study the electric field distribution and current emission in a miniaturized geometrical diode. Using Schwarz-Christoffel transformation, we calculate exactly the electric field inside a finite vacuum cathode-anode (A-K) gap with a single trapezoid protrusion on one of the electrode surfaces. It is found that there is a strong field enhancement on both electrodes near the protrusion, when the ratio of the A-K gap distance to the protrusion height d /h <2. The calculations are spot checked against COMSOL simulations. We calculate the effective field enhancement factor for the field emission current, by integrating the local Fowler-Nordheim current density along the electrode surfaces. We systematically examine the electric field enhancement and the current rectification of the miniaturized geometrical diode for various geometric dimensions and applied electric fields.

  2. Electric field induced optical gain of a hydrogenic impurity in a Cd{sub 0.8}Zn{sub 0.2}Se/ZnSe parabolic quantum dot

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jasmine, P. Christina Lily; Peter, A. John, E-mail: a.john.peter@gmail.com

    The dependence of electric field on the electronic and optical properties is investigated in a Cd{sub 0.8}Zn{sub 0.2}Se/ZnSe quantum dot. The hydrogenic binding energy, in the presence of electric field, is calculated with the spatial confinement effect. The electric field dependent optical gain with the photon energy is found using compact density matrix method. The results show that the electric field has a great influence on the optical properties of II-VI semiconductor quantum dot.

  3. Electrophoretic mobilities of counterions and a polymer in cylindrical pores

    PubMed Central

    Singh, Sunil P.; Muthukumar, M.

    2014-01-01

    We have simulated the transport properties of a uniformly charged flexible polymer chain and its counterions confined inside cylindrical nanopores under an external electric field. The hydrodynamic interaction is treated by describing the solvent molecules explicitly with the multiparticle collision dynamics method. The chain consisting of charged monomers and the counterions interact electrostatically with themselves and with the external electric field. We find rich behavior of the counterions around the polymer under confinement in the presence of the external electric field. The mobility of the counterions is heterogeneous depending on their location relative to the polymer. The adsorption isotherm of the counterions on the polymer depends nonlinearly on the electric field. As a result, the effective charge of the polymer exhibits a sigmoidal dependence on the electric field. This in turn leads to a nascent nonlinearity in the chain stretching and electrophoretic mobility of the polymer in terms of their dependence on the electric field. The product of the electric field and the effective polymer charge is found to be the key variable to unify our simulation data for various polymer lengths. Chain extension and the electrophoretic mobility show sigmoidal dependence on the electric field, with crossovers from the linear response regime to the nonlinear regime and then to the saturation regime. The mobility of adsorbed counterions is nonmonotonic with the electric field. For weaker and moderate fields, the adsorbed counterions move with the polymer and at higher fields they move opposite to the polymer's direction. We find that the effective charge and the mobility of the polymer decrease with a decrease in the pore radius. PMID:25240366

  4. Electric Fields, Cloud Microphysics, and Reflectivity in Anvils of Florida Thunderstorms

    NASA Technical Reports Server (NTRS)

    Dye, J. E.; Bateman, M. G.; Christian, H. J.; Grainger, C. A.; Hall, W. D.; Krider, E. P.; Lewis, S. A.; Mach, D. M.; Merceret, F. J.; Willett, J. C.; hide

    2006-01-01

    A coordinated aircraft - radar project that investigated the electric fields, cloud microphysics and radar reflectivity of thunderstorm anvils near Kennedy Space Center is described. Measurements from two cases illustrate the extensive nature of the microphysics and electric field observations. As the aircraft flew from the edges of anvils into the interior, electric fields very frequently increased abruptly from approx.1 to >10 kV/m even though the particle concentrations and radar reflectivity increased smoothly. The abrupt increase in field usually occurred when the aircraft entered regions with a reflectivity of 10 to 15 dBZ. It is suggested that the abrupt increase in electric field may be because the charge advection from the storm core did not occur across the entire breadth of the anvil and was not constant in time. Screening layers were not detected near the edges of the anvils. Some long-lived anvils showed subsequent enhancement of electric field and reflectivity and growth of particles, which if localized, might be a factor in explaining the abrupt change of field in some cases. Comparisons of electric field magnitude with particle concentration or reflectivity for a combined data set that included all anvil measurements showed a threshold behavior. When the average reflectivity, such as in a 3-km cube, was less than approximately 5 dBZ, the electric field magnitude was <3 kV/m. Based on these findings, the Volume Averaged Height Integrated Radar Reflectivity (VAHIRR) is now being used by NASA, the Air Force and Federal Aviation Administration in new Lightning Launch Commit Criteria as a diagnostic for high electric fields in anvils.

  5. Influence of thermodynamic mechanism of inter- facial adsorption on purifying air-conditioning engineering under intensification of electric field

    NASA Astrophysics Data System (ADS)

    Chen, Yun-Yu

    2016-12-01

    As a kind of mass transfer process as well as the basis of separating and purifying mixtures, interfacial adsorption has been widely applied to fields like chemical industry, medical industry and purification engineering in recent years. Influencing factors of interfacial adsorption, in addition to the traditional temperature, intensity of pressure, amount of substance and concentration, also include external fields, such as magnetic field, electric field and electromagnetic field, etc. Starting from the point of thermodynamics and taking the Gibbs adsorption as the model, the combination of energy axiom and the first law of thermodynamics was applied to boundary phase, and thus the theoretical expression for the volume of interface absorption under electric field as well as the mathematical relationship between surface tension and electric field intensity was obtained. In addition, according to the obtained theoretical expression, the volume of interface absorption of ethanol solution under different electric field intensities and concentrations was calculated. Moreover, the mechanism of interfacial adsorption was described from the perspective of thermodynamics and the influence of electric field on interfacial adsorption was explained reasonably, aiming to further discuss the influence of thermodynamic mechanism of interfacial adsorption on purifying air-conditioning engineering under intensification of electric field.

  6. The contribution of inductive electric fields to particle energization in the inner magnetosphere

    NASA Astrophysics Data System (ADS)

    Ilie, R.; Toth, G.; Liemohn, M. W.; Chan, A. A.

    2017-12-01

    Assessing the relative contribution of potential versus inductive electric fields at the energization of the hot ion population in the inner magnetosphere is only possible by thorough examination of the time varying magnetic field and current systems using global modeling of the entire system. We present here a method to calculate the inductive and potential components of electric field in the entire magnetosphere region. This method is based on the Helmholtz vector decomposition of the motional electric field as calculated by the BATS-R-US model, and is subject to boundary conditions. This approach removes the need to trace independent field lines and lifts the assumption that the magnetic field lines can be treated as frozen in a stationary ionosphere. In order to quantify the relative contributions of potential and inductive electric fields at driving plasma sheet ions into the inner magnetosphere, we apply this method for the March 17th, 2013 geomagnetic storm. We present here the consequences of slow continuous changes in the geomagnetic field as well as the strong tail dipolarizations on the distortion of the near-Earth magnetic field and current systems. Our findings indicate that the inductive component of the electric field is comparable, and even higher at times than the potential component, suggesting that the electric field induced by the time varying magnetic field plays a crucial role in the overall particle energization in the inner magnetosphere.

  7. Geometric properties-dependent neural synchrony modulated by extracellular subthreshold electric field

    NASA Astrophysics Data System (ADS)

    Wei, Xile; Si, Kaili; Yi, Guosheng; Wang, Jiang; Lu, Meili

    2016-07-01

    In this paper, we use a reduced two-compartment neuron model to investigate the interaction between extracellular subthreshold electric field and synchrony in small world networks. It is observed that network synchronization is closely related to the strength of electric field and geometric properties of the two-compartment model. Specifically, increasing the electric field induces a gradual improvement in network synchrony, while increasing the geometric factor results in an abrupt decrease in synchronization of network. In addition, increasing electric field can make the network become synchronous from asynchronous when the geometric parameter is set to a given value. Furthermore, it is demonstrated that network synchrony can also be affected by the firing frequency and dynamical bifurcation feature of single neuron. These results highlight the effect of weak field on network synchrony from the view of biophysical model, which may contribute to further understanding the effect of electric field on network activity.

  8. General Matrix Inversion Technique for the Calibration of Electric Field Sensor Arrays on Aircraft Platforms

    NASA Technical Reports Server (NTRS)

    Mach, D. M.; Koshak, W. J.

    2007-01-01

    A matrix calibration procedure has been developed that uniquely relates the electric fields measured at the aircraft with the external vector electric field and net aircraft charge. The calibration method can be generalized to any reasonable combination of electric field measurements and aircraft. A calibration matrix is determined for each aircraft that represents the individual instrument responses to the external electric field. The aircraft geometry and configuration of field mills (FMs) uniquely define the matrix. The matrix can then be inverted to determine the external electric field and net aircraft charge from the FM outputs. A distinct advantage of the method is that if one or more FMs need to be eliminated or deemphasized [e.g., due to a malfunction), it is a simple matter to reinvert the matrix without the malfunctioning FMs. To demonstrate the calibration technique, data are presented from several aircraft programs (ER-2, DC-8, Altus, and Citation).

  9. Equatorial measurement of SAID electric fields and relation with the plasmapause location

    NASA Astrophysics Data System (ADS)

    Nishimura, Y.; Wygant, J.; Ono, T.; Iizima, M.; Kumamoto, A.; Brautigam, D.; Rich, F.

    2007-12-01

    In order to investigate the equatorial source of subauroral ion drifts (SAID) and its association with the plasmapause position, multi-spacecraft measurements of SAID are presented using the CRRES, Akebono, and DMSP. Direct measurement of the convection electric field and plasmapause density close to the equator is measured by the electric field instrument onboard the CRRES satellite, and the plasmasheet electrons and low energy part of the ring current ions are measured by the low energy plasma instrument. The CRRES satellite is on the dusk inner magnetosphere, and the DMSP-F8 and Akebono satellites are approximately on the same field line. Associated with a substorm onset at 16:40 UT on February 20, 1991, the DMSP-F8 satellite at 19 MLT measures SAID with a maximum westward velocity of 1,500 m/s. The CRRES satellite is on outbound in the inner magnetosphere at ~21 MLT and ~5 RE at the onset of the substorm. It measures increase of DC electric field with 0.4 mV/m in the plasmasphere just after the substorm onset. Thirty minutes later, injection of ring current ions are observed in the plasmasphere with Bz decrease. After the crossing of the plasmapause, the electric field increases to 0.8 mV/m. At the same time, the spacecraft enters the plasmasheet, and the DC electric field disappears. The same time sequence is also identified in other SAID events detected on the dusk inner magnetosphere. The above CRRES measurement indicates that DC electric field is intensified in a narrow region between the ring current and electron plasmasheet after the onset of the substorm. Although the E*B drift points sunward in this region, this region with enhanced electric field is filled with plasmaspheric plasma without abrupt density change. The position where the convection electric field is equal to the corotation electric field locates inside the plasmapause. The plasmapause coincides with inner edge of the plasmasheet. This association suggests that the plasmaspheric plasma is depleted by the plasmasheet electrons, possibly by the enhanced E*B drift earthward of the plasmasheet. During the SAID event on 16:40 UT on February 20, 1991, the Akebono satellite was approximately on the same field line of the CRRES satellite (21 MLT and 5 RE) 40 minutes later the substorm onset. It measures enhancement of electric field with 2 mV/m between L=5 and 6. The inner edge of the electric field corresponds to the inner edge of ring current ions, and the outer edge coincides with the plasmasheet electrons. This signature of the electric field intensification in the charge-separated region is in accordance with the CRRES measurement. This study has clarified that the equatorial source of SAID electric fields is charge separation of ring current ions and plasmasheet electrons by electric field associated with substorms. This is consistent with the theoretical study by Southwood and Wolf [1978] and low-altitude measurements by Anderson et al. [2001] by that the charge separation provides current and voltage sources and the electric field is increased by the low conductance of the subauroral ionosphere.

  10. Electric field around a dielectric elastomer actuator in proximity to the human body

    NASA Astrophysics Data System (ADS)

    McKenzie, Anita C.; Calius, Emilio P.; Anderson, Iain A.

    2008-03-01

    Dielectric elastomer actuators (DEAs) are a promising artificial muscle technology that will enable new kinds of prostheses and wearable rehabilitation devices. DEAs are driven by electric fields in the MV/m range and the dielectric elastomer itself is typically 30μm in thickness or more. Large operating voltages, in the order of several kilovolts, are then required to produce useful strains and these large voltages and the resulting electric fields could potentially pose problems when DEAs are used in close proximity to the human body. The fringing electric fields of a DEA in close association with the skin were modelled using finite element methods. The model was verified against a known analytic solution describing the electric field surrounding a capacitor in air. The agreement between the two is good, as the difference is less than 10% unless within 4.5mm of the DEA's lateral edges. As expected, it was found that for a DEA constructed with thinner dielectric layers, the fringe field strength dropped in direct proportion to the reduction in applied voltage, despite the internal field being maintained at the same level. More interestingly, modelling the electric field around stacked DEAs showed that for an even number of layers the electric field is an order of magnitude less than for an odd number of layers, due to the cancelling of opposing electric fields.

  11. Stepwise formation of H3O(+)(H2O)n in an ion drift tube: Empirical effective temperature of association/dissociation reaction equilibrium in an electric field.

    PubMed

    Nakai, Yoichi; Hidaka, Hiroshi; Watanabe, Naoki; Kojima, Takao M

    2016-06-14

    We measured equilibrium constants for H3O(+)(H2O)n-1 + H2O↔H3O(+)(H2O)n (n = 4-9) reactions taking place in an ion drift tube with various applied electric fields at gas temperatures of 238-330 K. The zero-field reaction equilibrium constants were determined by extrapolation of those obtained at non-zero electric fields. From the zero-field reaction equilibrium constants, the standard enthalpy and entropy changes, ΔHn,n-1 (0) and ΔSn,n-1 (0), of stepwise association for n = 4-8 were derived and were in reasonable agreement with those measured in previous studies. We also examined the electric field dependence of the reaction equilibrium constants at non-zero electric fields for n = 4-8. An effective temperature for the reaction equilibrium constants at non-zero electric field was empirically obtained using a parameter describing the electric field dependence of the reaction equilibrium constants. Furthermore, the size dependence of the parameter was thought to reflect the evolution of the hydrogen-bond structure of H3O(+)(H2O)n with the cluster size. The reflection of structural information in the electric field dependence of the reaction equilibria is particularly noteworthy.

  12. 76 FR 56745 - Notice of Availability of Government-Owned Inventions; Available for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... No. 12/175262: Coupled Electric Field Sensors for DC Target Electric Field Detection; U.S. Patent Application No. 12/732023: Coupled Bi-Stable Microcircuit System for Ultra-Sensitive Electrical and Magnetic... Electric Field Sensing Utilizing Differential Transistors Pairs. FOR FURTHER INFORMATION CONTACT: Brian Suh...

  13. Cryosurgery with Pulsed Electric Fields

    PubMed Central

    Daniels, Charlotte S.; Rubinsky, Boris

    2011-01-01

    This study explores the hypothesis that combining the minimally invasive surgical techniques of cryosurgery and pulsed electric fields will eliminate some of the major disadvantages of these techniques while retaining their advantages. Cryosurgery, tissue ablation by freezing, is a well-established minimally invasive surgical technique. One disadvantage of cryosurgery concerns the mechanism of cell death; cells at high subzero temperature on the outer rim of the frozen lesion can survive. Pulsed electric fields (PEF) are another minimally invasive surgical technique in which high strength and very rapid electric pulses are delivered across cells to permeabilize the cell membrane for applications such as gene delivery, electrochemotherapy and irreversible electroporation. The very short time scale of the electric pulses is disadvantageous because it does not facilitate real time control over the procedure. We hypothesize that applying the electric pulses during the cryosurgical procedure in such a way that the electric field vector is parallel to the heat flux vector will have the effect of confining the electric fields to the frozen/cold region of tissue, thereby ablating the cells that survive freezing while facilitating controlled use of the PEF in the cold confined region. A finite element analysis of the electric field and heat conduction equations during simultaneous tissue treatment with cryosurgery and PEF (cryosurgery/PEF) was used to study the effect of tissue freezing on electric fields. The study yielded motivating results. Because of decreased electrical conductivity in the frozen/cooled tissue, it experienced temperature induced magnified electric fields in comparison to PEF delivered to the unfrozen tissue control. This suggests that freezing/cooling confines and magnifies the electric fields to those regions; a targeting capability unattainable in traditional PEF. This analysis shows how temperature induced magnified and focused PEFs could be used to ablate cells in the high subzero freezing region of a cryosurgical lesion. PMID:22087224

  14. Electric field control in DC cable test termination by nano silicone rubber composite

    NASA Astrophysics Data System (ADS)

    Song, Shu-Wei; Li, Zhongyuan; Zhao, Hong; Zhang, Peihong; Han, Baozhong; Fu, Mingli; Hou, Shuai

    2017-07-01

    The electric field distributions in high voltage direct current cable termination are investigated with silicone rubber nanocomposite being the electric stress control insulator. The nanocomposite is composed of silicone rubber, nanoscale carbon black and graphitic carbon. The experimental results show that the physical parameters of the nanocomposite, such as thermal activation energy and nonlinearity-relevant coefficient, can be manipulated by varying the proportion of the nanoscale fillers. The numerical simulation shows that safe electric field distribution calls for certain parametric region of the thermal activation energy and nonlinearity-relevant coefficient. Outside the safe parametric region, local maximum of electric field strength around the stress cone appears in the termination insulator, enhancing the breakdown of the cable termination. In the presence of the temperature gradient, thermal activation energy and nonlinearity-relevant coefficient work as complementary factors to produce a reasonable electric field distribution. The field maximum in the termination insulator show complicate variation in the transient processes. The stationary field distribution favors the increase of the nonlinearity-relevant coefficient; for the transient field distribution in the process of negative lighting impulse, however, an optimized value of the nonlinearity-relevant coefficient is necessary to equalize the electric field in the termination.

  15. Electromagnetic coupling of spins and pseudospins in bilayer graphene

    NASA Astrophysics Data System (ADS)

    Winkler, R.; Zülicke, U.

    2015-03-01

    We present a theoretical study of bilayer-graphene's electronic properties in the presence of electric and magnetic fields. In contrast to known materials, including single-layer graphene, any possible coupling of physical quantities to components of the electric field has a counterpart where the analogous component of the magnetic field couples to exactly the same quantities. For example, a purely electric spin splitting appears as the magneto-electric analogue of the magnetic Zeeman spin splitting. The measurable thermodynamic response induced by magnetic and electric fields is thus completely symmetric. The Pauli magnetization induced by a magnetic field takes exactly the same functional form as the polarization induced by an electric field. Although they seem counterintuitive, our findings are consistent with fundamental principles such as time reversal symmetry. For example, only a magnetic field can give rise to a macroscopic spin polarization, whereas only a perpendicular electric field can induce a macroscopic polarization of the sublattice-related pseudospin in bilayer graphene. These rules enforced by symmetry for the matter-field interactions clarify the nature of spins versus pseudospins. We have obtained numerical values of prefactors for relevant terms. NSF Grant DMR-1310199 and Marsden Fund Contract No. VUW0719.

  16. Field distribution and DNA transport in solid tumors during electric field-mediated gene delivery.

    PubMed

    Henshaw, Joshua W; Yuan, Fan

    2008-02-01

    Gene therapy has a great potential in cancer treatment. However, the efficacy of cancer gene therapy is currently limited by the lack of a safe and efficient means to deliver therapeutic genes into the nucleus of tumor cells. One method under investigation for improving local gene delivery is based on the use of pulsed electric field. Despite repeated demonstration of its effectiveness in vivo, the underlying mechanisms behind electric field-mediated gene delivery remain largely unknown. Without a thorough understanding of these mechanisms, it will be difficult to further advance the gene delivery. In this review, the electric field-mediated gene delivery in solid tumors will be examined by following individual transport processes that must occur in vivo for a successful gene transfer. The topics of examination include: (i) major barriers for gene delivery in the body, (ii) distribution of electric fields at both cell and tissue levels during the application of external fields, and (iii) electric field-induced transport of genes across each of the barriers. Through this approach, the review summarizes what is known about the mechanisms behind electric field-mediated gene delivery and what require further investigations in future studies.

  17. Multi-point Measurements of Relativistic Electrons in the Magnetosphere

    NASA Astrophysics Data System (ADS)

    Li, X.; Selesnick, R.; Baker, D. N.; Blake, J. B.; Schiller, Q.; Blum, L. W.; Zhao, H.; Jaynes, A. N.; Kanekal, S.

    2014-12-01

    We take an advantage of five different DC electric field measurements in the plasma sheet available from the EFW double probe experiment, EDI electron drift instrument, CODIF and HIA ion spectrometers, and PEACE electron spectrometer on the four Cluster spacecraft. The calibrated observations of the three spectrometers are used to determine the proton and electron velocity moments. The velocity moments can be used to estimate the proton and electron drift velocity and furthermore the DC electric field, assuming that the electron and proton velocity perpendicular to the magnetic field is dominated by the ExB drift motion. Naturally when ions and electrons do not perform a proper drift motion, which can happen in the plasma sheet, the estimated DC electric field from ion and electron motion is not correct. However, surprisingly often the DC electric fields estimated from electron and ion motions are identical suggesting that this field is a real DC electric field around the measurement point. As the measurement techniques are so different, it is quite plausible that when two different measurements yield the same DC electric field, it is the correct field. All five measurements of the DC electric field are usually not simultaneously available, especially on Cluster 2 where CODIF and HIA are not operational, or on Cluster 4 where EDI is off. In this presentation we investigate DC electric field in various transient plasma sheet events such as dipolarization events and BBF's and how the five measurements agree or disagree. There are plenty of important issues that are considered, e.g., (1) what kind of DC electric fields exist in such events and what are their spatial scales, (2) do electrons and ions perform ExB drift motions in these events, and (3) how well the instruments have been calibrated.

  18. On the electric field model for an open magnetosphere

    NASA Technical Reports Server (NTRS)

    Wang, Zhi; Ashour-Abdalla, Maha; Walker, Raymond J.

    1993-01-01

    We have developed a new canonical separator line type magnetospheric magnetic field and electric field model for use in magnetospheric calculations, we determine the magnetic and electric field by controlling the reconnection rate at the subsolar magnetopause. The model is applicable only for purely southward interplanetary magnetic field (IMF). We have obtained a more realistic magnetotail configuration by applying a stretch transformation to an axially symmetric field solution. We also discuss the Stern singularity in which there is an electric field singlarity in the canonical separate line models for B(sub y) not = to 0 by using a new technique that solves for the electric field along a field line directly instead of determining it by a potential mapping. The singularity not only causes an infinite electric field on the polar cap, but also causes the boundary conditions at plus infinity and minus infinity in the solar wind to contradict each other. This means that the canonical separator line models do not represent the open magnetosphere well, except for the case of purely southward IMF.

  19. Water-Constrained Electric Sector Capacity Expansion Modeling Under Climate Change Scenarios

    NASA Astrophysics Data System (ADS)

    Cohen, S. M.; Macknick, J.; Miara, A.; Vorosmarty, C. J.; Averyt, K.; Meldrum, J.; Corsi, F.; Prousevitch, A.; Rangwala, I.

    2015-12-01

    Over 80% of U.S. electricity generation uses a thermoelectric process, which requires significant quantities of water for power plant cooling. This water requirement exposes the electric sector to vulnerabilities related to shifts in water availability driven by climate change as well as reductions in power plant efficiencies. Electricity demand is also sensitive to climate change, which in most of the United States leads to warming temperatures that increase total cooling-degree days. The resulting demand increase is typically greater for peak demand periods. This work examines the sensitivity of the development and operations of the U.S. electric sector to the impacts of climate change using an electric sector capacity expansion model that endogenously represents seasonal and local water resource availability as well as climate impacts on water availability, electricity demand, and electricity system performance. Capacity expansion portfolios and water resource implications from 2010 to 2050 are shown at high spatial resolution under a series of climate scenarios. Results demonstrate the importance of water availability for future electric sector capacity planning and operations, especially under more extreme hotter and drier climate scenarios. In addition, region-specific changes in electricity demand and water resources require region-specific responses that depend on local renewable resource availability and electricity market conditions. Climate change and the associated impacts on water availability and temperature can affect the types of power plants that are built, their location, and their impact on regional water resources.

  20. Manipulation of positron orbits in a dipole magnetic field with fluctuating electric fields

    NASA Astrophysics Data System (ADS)

    Saitoh, H.; Horn-Stanja, J.; Nißl, S.; Stenson, E. V.; Hergenhahn, U.; Pedersen, T. Sunn; Singer, M.; Dickmann, M.; Hugenschmidt, C.; Stoneking, M. R.; Danielson, J. R.; Surko, C. M.

    2018-01-01

    We report the manipulation of positron orbits in a toroidal dipole magnetic field configuration realized with electric fields generated by segmented electrodes. When the toroidal circulation motion of positrons in the dipole field is coupled with time-varying electric fields generated by azimuthally segmented outer electrodes, positrons undergo oscillations of their radial positions. This enables quick manipulation of the spatial profiles of positrons in a dipole field trap by choosing appropriate frequency, amplitude, phase, and gating time of the electric fields. According to numerical orbit analysis, we applied these electric fields to positrons injected from the NEPOMUC slow positron facility into a prototype dipole field trap experiment with a permanent magnet. Measurements with annihilation γ-rays clearly demonstrated the efficient compression effects of positrons into the strong magnetic field region of the dipole field configuration. This positron manipulation technique can be used as one of essential tools for future experiments on the formation of electron-positron plasmas.

  1. On The Design and Implementation of a New Electric-Field Meter with Reciprocating Shutter and Field-Change-Antenna Option

    NASA Astrophysics Data System (ADS)

    Swenson, J.; Byerley, L. G.; Bogoev, I.; Hinckley, A.; Beasley, W. H.

    2003-12-01

    The atmospheric electric field is a unique indicator of locally disturbed weather, local thunderstorms and local atmospheric electrical hazards. Yet, surprisingly, routine observations of ambient electric field have never been included in the canonical suite of measured meteorological variables. This notable omission may be a result of the historically high costs to acquire, install, and maintain conventional electric-field mills. To reduce costs and overcome limitations of traditional field meters, Campbell Scientific, Inc. has developed an electric-field meter (patent pending) with a reciprocating shutter that eliminates the problem of making electrical contact with a rotating shaft. The reciprocating action is under microprocessor control, so the sample rate can be varied in response to measured conditions. Between samples of electric field, the shutter can even be left open indefinitely, allowing the instrument to function as a field-change antenna. Since the shutter is closed before and after each measurement in field-meter mode, it is relatively easy to account for drift and offsets automatically, so that measurements can be made even if the electrode insulator becomes degraded by conductive deposits of the types likely to be encountered in severe outdoor environments. Because the motor is energized for only a small fraction of each measurement cycle, average power consumption is exceptionally low, making the new field meter especially suitable for solar-powered applications such as automated remote meteorological stations. Some preliminary observations demonstrate the capabilities of the instrument.

  2. Nongyrotropic Electrons in Guide Field Reconnection

    NASA Technical Reports Server (NTRS)

    Wendel, D. E.; Hesse, M.; Bessho, N.; Adrian, M. L.; Kuznetsova, M.

    2016-01-01

    We apply a scalar measure of nongyrotropy to the electron pressure tensor in a 2D particle-in-cell simulation of guide field reconnection and assess the corresponding electron distributions and the forces that account for the nongyrotropy. The scalar measure reveals that the nongyrotropy lies in bands that straddle the electron diffusion region and the separatrices, in the same regions where there are parallel electric fields. Analysis of electron distributions and fields shows that the nongyrotropy along the inflow and outflow separatrices emerges as a result of multiple populations of electrons influenced differently by large and small-scale parallel electric fields and by gradients in the electric field. The relevant parallel electric fields include large-scale potential ramps emanating from the x-line and sub-ion inertial scale bipolar electron holes. Gradients in the perpendicular electric field modify electrons differently depending on their phase, thus producing nongyrotropy. Magnetic flux violation occurs along portions of the separatrices that coincide with the parallel electric fields. An inductive electric field in the electron EB drift frame thus develops, which has the effect of enhancing nongyrotropies already produced by other mechanisms and under certain conditions producing their own nongyrotropy. Particle tracing of electrons from nongyrotropic populations along the inflows and outflows shows that the striated structure of nongyrotropy corresponds to electrons arriving from different source regions. We also show that the relevant parallel electric fields receive important contributions not only from the nongyrotropic portion of the electron pressure tensor but from electron spatial and temporal inertial terms as well.

  3. Towards more Global Coordination of Atmospheric Electricity Measurements (GloCAEM)

    NASA Astrophysics Data System (ADS)

    Nicoll, Keri; Harrison, Giles

    2017-04-01

    Earth's atmospheric electrical environment has been studied since the 1750s but its more recent applications to science questions around clouds and climate highlight the incompleteness of our understanding, in part due to lack of suitable global measurements. The Global Electric Circuit (GEC) sustains the near-surface fair weather (FW) electric field, which is present globally in regions which are not strongly electrically disturbed by weather or pollution. It can be measured routinely at the surface using well established instrumentation such as electric field mills. Despite the central role of lightning as a weather hazard and the potentially widespread importance of charge for atmospheric processes, research is hampered by the fragmented nature of surface atmospheric electricity measurements. This makes anything other than local studies in fortuitous fair weather conditions difficult. In contrast to detection of global lightning using satellite measurements and ground-based radio networks, the FW electric field and GEC cannot be measured by remote sensing and no similar measurement networks exist for its study. This presents an opportunity as many researchers worldwide now make high temporal resolution measurements of the FW electric field routinely, which is neither coordinated nor exploited. The GLOCAEM (Global Coordination of Atmospheric Electricity Measurements) project is currently bringing some of these experts together to make the first steps towards an effective global network for FW atmospheric electricity monitoring. A specific objective of the project is to establish the first modern archive of international FW atmospheric electric field data in close to real time to allow global studies of atmospheric electricity to be straightforwardly and robustly performed. Data will be archived through the UK Centre for Environmental Data Analysis (CEDA) and will be available for download by users from early 2018. Both 1 second and 1 minute electric field data will be archived, along with meteorological measurements (if available) for ease of interpretation of electrical measurements. Although the primary aim of the project is to provide a close to real time electric field database, archiving of existing historical electric field datasets is also planned to extend the range of studies possible. This presentation will provide a summary of progress with the GLOCAEM project.

  4. A study of the glow discharge plasma jet of the novel Hamburger-electrode

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Wenzheng, E-mail: wzhliu@bjtu.edu.cn; Ma, Chuanlong, E-mail: 15121452@bjtu.edu.cn; Yang, Xiao

    2016-08-15

    To generate atmospheric pressure glow discharge plasma jets (APGDPJs), a novel Hamburger-electrode was proposed. Through the study on electric field distributions, flow field distributions, and characteristics of the discharge and jet, we found that adopting the mode of dielectric barrier discharge with non-uniform thickness of dielectric, it was easy to form the strong electric field areas which were conducive to generate discharge and electric field distributions with large electric field intensity in the narrow gap and weak electric field intensity in the wide gap that were not inclined to form a filament discharge. Using the structure of evenly distributed innermore » electrodes, it was easy to weaken the pressure of strong electric field areas and form flow field distributions which is beneficial for taking out the high density charged particles and generating APGDPJs. Stable APGDPJs in nitrogen with 3.5 mm in diameter and 9 mm in length were formed by using the novel Hamburger-electrode.« less

  5. The magnetospheric electric field and convective processes as diagnostics of the IMF and solar wind

    NASA Technical Reports Server (NTRS)

    Kaye, S. M.

    1979-01-01

    Indirect measurements of the convection field as well as direct of the ionospheric electric field provide a means to at least monitor quanitatively solar wind processes. For instance, asymmetries in the ionospheric electric field and ionospheric Hall currents over the polar cap reflect the solar wind sector polarity. A stronger electric field, and thus convective flow, is found on the side of the polar cap where the y component of the IMF is parallel to the y component of the geomagnetic field. Additionally, the magnitude of the electric field and convective southward B sub Z and/or solar wind velocity, and thus may indicate the arrival at Earth of an interaction region in the solar wind. It is apparent that processes associated with the convention electric field may be used to predict large scale features in the solar wind; however, with present empirical knowledge it is not possible to make quantitative predictions of individual solar wind or IMF parameters.

  6. Theoretical evaluation of maximum electric field approximation of direct band-to-band tunneling Kane model for low bandgap semiconductors

    NASA Astrophysics Data System (ADS)

    Dang Chien, Nguyen; Shih, Chun-Hsing; Hoa, Phu Chi; Minh, Nguyen Hong; Thi Thanh Hien, Duong; Nhung, Le Hong

    2016-06-01

    The two-band Kane model has been popularly used to calculate the band-to-band tunneling (BTBT) current in tunnel field-effect transistor (TFET) which is currently considered as a promising candidate for low power applications. This study theoretically clarifies the maximum electric field approximation (MEFA) of direct BTBT Kane model and evaluates its appropriateness for low bandgap semiconductors. By analysing the physical origin of each electric field term in the Kane model, it has been elucidated in the MEFA that the local electric field term must be remained while the nonlocal electric field terms are assigned by the maximum value of electric field at the tunnel junction. Mathematical investigations have showed that the MEFA is more appropriate for low bandgap semiconductors compared to high bandgap materials because of enhanced tunneling probability in low field regions. The appropriateness of the MEFA is very useful for practical uses in quickly estimating the direct BTBT current in low bandgap TFET devices.

  7. A sensor for vector electric field measurements through a nonlinear anisotropic optical crystal

    NASA Astrophysics Data System (ADS)

    Barbieri, Luca; Gondola, Marco; Potenza, Marco; Villa, Andrea; Malgesini, Roberto

    2017-11-01

    Electrical applications require the development of electric field sensors that can reproduce vector electric field waveforms with a very large spectral width ranging from 50 Hz to at least 70 MHz. This makes it possible to measure both the normal operation modes of electrical components and abnormal behaviors such as the corona emission and partial discharges. In this work, we aim to develop a fully dielectric sensor capable of measuring two components of the electric field using a wide class of optical crystals including anisotropic ones, whereas most of the efforts in this field have been devoted to isotropic crystals. We report the results of the measurements performed at 50 Hz and with a lightning impulse, to validate the sensor.

  8. Current densities in a pregnant woman model induced by simultaneous ELF electric and magnetic field exposure

    NASA Astrophysics Data System (ADS)

    Cech, R.; Leitgeb, N.; Pediaditis, M.

    2008-01-01

    The pregnant woman model SILVY was studied to ascertain to what extent the electric current densities induced by 50 Hz homogeneous electric and magnetic fields increase in the case of simultaneous exposure. By vectorial addition of the electric current densities, it could be shown that under worst case conditions the basic restrictions recommended by ICNIRP (International Commission on Non-Ionizing Radiation Protection) guidelines are exceeded within the central nervous system (CNS) of the mother, whereas in sole field exposure they are not. However, within the foetus the induced current densities do not comply with basic restrictions, either from single reference-level electric fields or from simultaneous exposure to electric and magnetic fields. Basic limits were considerably exceeded.

  9. Convection Electric Field Observations by THEMIS and the Van Allen Probes

    NASA Astrophysics Data System (ADS)

    Califf, S.; Li, X.; Bonnell, J. W.; Wygant, J. R.; Malaspina, D.; Hartinger, M.; Thaller, S. A.

    2013-12-01

    We present direct electric field measurements made by THEMIS and the Van Allen Probes in the inner magnetosphere, focusing on the large-scale, near-DC convection electric field. The convection electric field drives plasma Earthward from the tail into the inner magnetosphere, playing a critical role in forming the ring current. Although it is normally shielded deep inside the magnetosphere, during storm times this large-scale electric field can penetrate to low L values (L < 3), eroding the plasmasphere and also providing a mechanism for ~100 keV electron injection into the slot region and inner radiation belt. The relationship of the convection electric field with the plasmasphere is also important for understanding the dynamic outer radiation belt, as the plasmapause boundary has been strongly correlated with the dynamic variation of the outer radiation belt electrons.

  10. Low- and mid-latitude ionospheric electric fields during the January 1984 GISMOS campaign

    NASA Technical Reports Server (NTRS)

    Fejer, B. G.; Kelley, M. C.; Senior, C.; De La Beaujardiere, O.; Lepping, R.

    1990-01-01

    The electrical coupling between the high-, middle-, and low-latitude ionospheres during January 17-19, 1984 is examined, using interplanetary and high-latitude magnetic field data together with F region plasma drift measurements from the EISCAT, Sondre Stromfjord, Millstone Hill, Saint-Santin, Arecibo, and Jicamarca incoherent scatter radars. The penetration both the zonal and meridional electric field components of high-latitude origin into the low-latitude and the equatorial ionospheres are studied. The observations in the postmidnight sector are used to compare the longitudinal variations of the zonal perturbation electric field with predictions made from global convection models. The results show that the meridional electric field perturbations are considerably more attenuated with decreasing latitude than the zonal fluctuations. It is concluded that variations in the meridional electric field at low latitudes are largely due to dynamo effects.

  11. Electric Field Simulation of Surge Capacitors with Typical Defects

    NASA Astrophysics Data System (ADS)

    Zhang, Chenmeng; Mao, Yuxiang; Xie, Shijun; Zhang, Yu

    2018-03-01

    The electric field of power capacitors with different typical defects in DC working condition and impulse oscillation working condition is studied in this paper. According to the type and location of defects and considering the influence of space charge, two-dimensional models of surge capacitors with different typical defects are simulated based on ANSYS. The distribution of the electric field inside the capacitor is analyzed, and the concentration of electric field and its influence on the insulation performance are obtained. The results show that the type of defects, the location of defects and the space charge all affect the electric field distribution inside the capacitor in varying degrees. Especially the electric field distortion in the local area such as sharp corners and burrs is relatively larger, which increases the probability of partial discharge inside the surge capacitor.

  12. Photodetachment dynamics in a time-dependent oscillating electric field

    NASA Astrophysics Data System (ADS)

    Wang, De-hua; Xu, Qin-feng; Du, Jie

    2017-03-01

    Using the time-dependent form of closed orbit theory, as developed by Haggerty and Delos [M.R. Haggerty, J.B. Delos, Phys. Rev. A 61, 053406 (2000)], and by Yang and Robicheaux [B.C. Yang, F. Robicheaux, Phys. Rev. A 93, 053413 (2016)], we study the photodetachment dynamics of a hydrogen negative ion in a time-dependent oscillating electric field. Compared to the photodetachment in a static electric field, the photodetachment dynamics of a negative ion in the time-dependent oscillating electric field become much more complicated but more interesting. Since the applied electric field is oscillating with time, the photodetachment cross section of the negative ion in the oscillating electric field is time-dependent. In a time-dependent framework, we put forward an analytical formula for calculating the instantaneous photodetachment cross section of this system. Our study suggests that the instantaneous photodetachment cross section exhibits oscillatory structure, which depends sensitively on the frequency of the oscillating electric field. With increasing frequency of the oscillating electric field, the number of closed orbits increases and the oscillatory structure in the photodetachment cross section becomes much more complicated. The connection between the detached electron's closed orbit with the oscillating cross section is analyzed quantitatively. This study provides a clear and intuitive picture for the photodetachment processes of a negative ion in the presence of an oscillating electric field. We hope that our work will be useful in guiding future experimental research.

  13. Coordinated EV adoption: double-digit reductions in emissions and fuel use for $40/vehicle-year.

    PubMed

    Choi, Dong Gu; Kreikebaum, Frank; Thomas, Valerie M; Divan, Deepak

    2013-09-17

    Adoption of electric vehicles (EVs) would affect the costs and sources of electricity and the United States efficiency requirements for conventional vehicles (CVs). We model EV adoption scenarios in each of six regions of the Eastern Interconnection, containing 70% of the United States population. We develop electricity system optimization models at the multidecade, day-ahead, and hour-ahead time scales, incorporating spatial wind energy modeling, endogenous modeling of CV efficiencies, projections for EV efficiencies, and projected CV and EV costs. We find two means to reduce total consumer expenditure (TCE): (i) controlling charge timing and (ii) unlinking the fuel economy regulations for CVs from EVs. Although EVs provide minimal direct GHG reductions, controlled charging provides load flexibility, lowering the cost of renewable electricity. Without EVs, a 33% renewable electricity standard (RES) would cost $193/vehicle-year more than the reference case (10% RES). Combining a 33% RES, EVs with controlled charging and unlinking would reduce combined electric- and vehicle-sector CO2 emissions by 27% and reduce gasoline consumption by 59% for $40/vehicle-year more than the reference case. Coordinating EV adoption with adoption of controlled charging, unlinked fuel economy regulations, and renewable electricity standards would provide low-cost reductions in emissions and fuel usage.

  14. Assessment of the electrochemical effects of pulsed electric fields in a biological cell suspension.

    PubMed

    Chafai, Djamel Eddine; Mehle, Andraž; Tilmatine, Amar; Maouche, Bachir; Miklavčič, Damijan

    2015-12-01

    Electroporation of cells is successfully used in biology, biotechnology and medicine. Practical problems still arise in the electroporation of cells in suspension. For example, the determination of cell electroporation is still a demanding and time-consuming task. Electric pulses also cause contamination of the solution by the metal released from the electrodes and create local enhancements of the electric field, leading to the occurrence of electrochemical reactions at the electrode/electrolyte interface. In our study, we investigated the possibility of assessing modifications to the cell environment caused by pulsed electric fields using electrochemical impedance spectroscopy. We designed an experimental protocol to elucidate the mechanism by which a pulsed electric field affects the electrode state in relation to different electrolyte conductivities at the interface. The results show that a pulsed electric field affects electrodes and its degree depends on the electrolyte conductivity. Evolution of the electrochemical reaction rate depends on the initial free charges and those generated by the pulsed electric field. In the presence of biological cells, the initial free charges in the medium are reduced. The electrical current path at low frequency is longer, i.e., conductivity is decreased, even in the presence of increased permeability of the cell membrane created by the pulsed electric field. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Electric field variations measured continuously in free air over a conductive thin zone in the tilted Lias-epsilon black shales near Osnabrück, Northwest Germany

    NASA Astrophysics Data System (ADS)

    Gurk, M.; Bosch, F. P.; Tougiannidis, N.

    2013-04-01

    Common studies on the static electric field distribution over a conductivity anomaly use the self-potential method. However, this method is time consuming and requires nonpolarizable electrodes to be placed in the ground. Moreover, the information gained by this method is restricted to the horizontal variations of the electric field. To overcome the limitation in the self-potential technique, we conducted a field experiment using a non conventional technique to assess the static electric field over a conductivity anomaly. We use two metallic potential probes arranged on an insulated boom with a separation of 126 cm. When placed into the electric field of the free air, a surface charge will be induced on each probe trying to equalize with the potential of the surrounding atmosphere. The use of a plasma source at both probes facilitated continuous and quicker measurement of the electric field in the air. The present study shows first experimental measurements with a modified potential probe technique (MPP) along a 600-meter-long transect to demonstrate the general feasibility of this method for studying the static electric field distribution over shallow conductivity anomalies. Field measurements were carried out on a test site on top of the Bramsche Massif near Osnabrück (Northwest Germany) to benefit from a variety of available near surface data over an almost vertical conductivity anomaly. High resolution self-potential data served in a numerical analysis to estimate the expected individual components of the electric field vector. During the experiment we found more anomalies in the vertical and horizontal components of the electric field than self-potential anomalies. These contrasting findings are successfully cross-validated with conventional near surface geophysical methods. Among these methods, we used self-potential, radiomagnetotelluric, electric resistivity tomography and induced polarization data to derive 2D conductivity models of the subsurface in order to infer the geometrical properties and the origin of the conductivity anomaly in the survey area. The presented study demonstrates the feasibility of electric field measurements in free air to detect and study near surface conductivity anomalies. Variations in Ez correlate well with the conductivity distribution obtained from resistivity methods. Compared to the self-potential technique, continuously free air measurements of the electric field are more rapid and of better lateral resolution combined with the unique ability to analyze vertical components of the electric field which are of particular importance to detect lateral conductivity contrasts. Mapping Ez in free air is a good tool to precisely map lateral changes of the electric field distribution in areas where SP generation fails. MPP offers interesting application in other geophysical techniques e.g. in time domain electromagnetics, DC and IP. With this method we were able to reveal a ca. 150 m broad zone of enhanced electric field strength.

  16. Temperature Modulation of Electric Fields in Biological Matter

    PubMed Central

    Daniels, Charlotte S.; Rubinsky, Boris

    2011-01-01

    Pulsed electric fields (PEF) have become an important minimally invasive surgical technology for various applications including genetic engineering, electrochemotherapy and tissue ablation. This study explores the hypothesis that temperature dependent electrical parameters of tissue can be used to modulate the outcome of PEF protocols, providing a new means for controlling and optimizing this minimally invasive surgical procedure. This study investigates two different applications of cooling temperatures applied during PEF. The first case utilizes an electrode which simultaneously delivers pulsed electric fields and cooling temperatures. The subsequent results demonstrate that changes in electrical properties due to temperature produced by this configuration can substantially magnify and confine the electric fields in the cooled regions while almost eliminating electric fields in surrounding regions. This method can be used to increase precision in the PEF procedure, and eliminate muscle contractions and damage to adjacent tissues. The second configuration considered introduces a third probe that is not electrically active and only applies cooling boundary conditions. This second study demonstrates that in this probe configuration the temperature induced changes in electrical properties of tissue substantially reduce the electric fields in the cooled regions. This novel treatment can potentially be used to protect sensitive tissues from the effect of the PEF. Perhaps the most important conclusion of this investigation is that temperature is a powerful and accessible mechanism to modulate and control electric fields in biological tissues and can therefore be used to optimize and control PEF treatments. PMID:21695144

  17. Measurement of large parallel and perpendicular electric fields on electron spatial scales in the terrestrial bow shock.

    PubMed

    Bale, S D; Mozer, F S

    2007-05-18

    Large parallel (

  18. Computational dosimetry of induced electric fields during realistic movements in the vicinity of a 3 T MRI scanner

    NASA Astrophysics Data System (ADS)

    Laakso, Ilkka; Kännälä, Sami; Jokela, Kari

    2013-04-01

    Medical staff working near magnetic resonance imaging (MRI) scanners are exposed both to the static magnetic field itself and also to electric currents that are induced in the body when the body moves in the magnetic field. However, there are currently limited data available on the induced electric field for realistic movements. This study computationally investigates the movement induced electric fields for realistic movements in the magnetic field of a 3 T MRI scanner. The path of movement near the MRI scanner is based on magnetic field measurements using a coil sensor attached to a human volunteer. Utilizing realistic models for both the motion of the head and the magnetic field of the MRI scanner, the induced fields are computationally determined using the finite-element method for five high-resolution numerical anatomical models. The results show that the time-derivative of the magnetic flux density (dB/dt) is approximately linearly proportional to the induced electric field in the head, independent of the position of the head with respect to the magnet. This supports the use of dB/dt measurements for occupational exposure assessment. For the path of movement considered herein, the spatial maximum of the induced electric field is close to the basic restriction for the peripheral nervous system and exceeds the basic restriction for the central nervous system in the international guidelines. The 99th percentile electric field is a considerably less restrictive metric for the exposure than the spatial maximum electric field; the former is typically 60-70% lower than the latter. However, the 99th percentile electric field may exceed the basic restriction for dB/dt values that can be encountered during tasks commonly performed by MRI workers. It is also shown that the movement-induced eddy currents may reach magnitudes that could electrically stimulate the vestibular system, which could play a significant role in the generation of vertigo-like sensations reported by people moving in a strong static magnetic field.

  19. Asymptotic expansion of pair production probability in a time-dependent electric field

    NASA Astrophysics Data System (ADS)

    Arai, Takashi

    2015-12-01

    We study particle creation in a single pulse of an electric field in scalar quantum electrodynamics. We investigate the parameter condition for the case where the dynamical pair creation and Schwinger mechanism respectively dominate. Then, an asymptotic expansion for the particle distribution in terms of the time interval of the applied electric field is derived. We compare our result with particle creation in a constant electric field with a finite-time interval. These results coincide in an extremely strong field, however they differ in general field strength. We interpret the reason of this difference as a nonperturbative effect of high-frequency photons in external electric fields. Moreover, we find that the next-to-leading-order term in our asymptotic expansion coincides with the derivative expansion of the effective action.

  20. Nanomechanical electric and electromagnetic field sensor

    DOEpatents

    Datskos, Panagiotis George; Lavrik, Nickolay

    2015-03-24

    The present invention provides a system for detecting and analyzing at least one of an electric field and an electromagnetic field. The system includes a micro/nanomechanical oscillator which oscillates in the presence of at least one of the electric field and the electromagnetic field. The micro/nanomechanical oscillator includes a dense array of cantilevers mounted to a substrate. A charge localized on a tip of each cantilever interacts with and oscillates in the presence of the electric and/or electromagnetic field. The system further includes a subsystem for recording the movement of the cantilever to extract information from the electric and/or electromagnetic field. The system further includes a means of adjusting a stiffness of the cantilever to heterodyne tune an operating frequency of the system over a frequency range.

  1. CRIT II electric, magnetic, and density measurements within an ionizing neutral stream

    NASA Technical Reports Server (NTRS)

    Swenson, C. M.; Kelley, M. C.; Primdahl, F.; Baker, K. D.

    1990-01-01

    Measurements from rocket-borne sensors inside a high-velocity neutral barium beam show a-factor-of-six increase in plasma density in a moving ionizing front. This region was colocated with intense fluctuating electric fields at frequencies well under the lower hybrid frequency for a barium plasma. Large quasi-dc electric and magnetic field fluctuations were also detected with a large component of the current and the electric field parallel to B(0). An Alfven wave with a finite electric field component parallel to the geomagnetic field was observed to propagate along B(0), where it was detected by an instrumented subpayload.

  2. Electric Field Distribution in High Voltage Power Modules Using Finite Element Simulations

    NASA Astrophysics Data System (ADS)

    Wang, Zhao; Liu, Yaoning

    2018-03-01

    With the development of the high voltage insulated gate bipolar transistor (IGBT) power module, it leads to serious problems concerning the electric field insulation. The electric field capabilities of the silicone gels used in the power module encapsulation directly affect the module insulation. Some solutions have been developed to optimize the electric field and reliability. In this letter, the finite element simulation was used to analyze and localize the maximum electric field position; solutions were proposed to improve the module insulation. It’s demonstrated that BaTiO3 silicone composite is a promising insulation material for high voltage power device.

  3. [Research advances of anti-tumor immune response induced by pulse electric field ablation].

    PubMed

    Cui, Guang-ying; Diao, Hong-yan

    2015-11-01

    As a novel tumor therapy, pulse electric field has shown a clinical perspective. This paper reviews the characteristics of tumor ablation by microsecond pulse and nanosecond pulse electric field, and the research advances of anti-tumor immune response induced by pulse electric field ablation. Recent researches indicate that the pulse electric field not only leads to a complete ablation of local tumor, but also stimulates a protective immune response, thereby inhibiting tumor recurrence and metastasis. These unique advantages will show an extensive clinical application in the future. However, the mechanism of anti-tumor immune response and the development of related tumor vaccine need further studies.

  4. Controllable deformation of salt water-filled carbon nanotubes using an electric field with application to molecular sieving

    NASA Astrophysics Data System (ADS)

    Ye, Hongfei; Zheng, Yonggang; Zhang, Zhongqiang; Zhang, Hongwu; Chen, Zhen

    2016-08-01

    Precisely controlling the deformation of carbon nanotubes (CNTs) has practical application in the development of nanoscale functional devices, although it is a challenging task. Here, we propose a novel method to guide the deformation of CNTs through filling them with salt water and applying an electric field. With the electric field along the axial direction, the height of CNTs is enlarged by the axial electric force due to the internal ions and polar water molecules. Under an electric field with two mutually orthogonal components, the transverse electric force could further induce the bending deformation of CNTs. Based on the classical rod and beam theories, two mechanical models are constructed to verify and quantitatively describe the relationships between the tension and bending deformations of CNTs and the electric field intensity. Moreover, by means of the electric field-driven tension behavior of CNTs, we design a stretchable molecular sieve to control the flow rate of mixed gas and collect a single high-purity gas. The present work opens up new avenues in the design and fabrication of nanoscale controlling units.

  5. DC and AC Electric Field Measurements by Spin-Plane Double Probes Onboard MMS

    NASA Astrophysics Data System (ADS)

    Lindqvist, P. A.; Marklund, G. T.; Khotyaintsev, Y. V.; Ergun, R. E.; Goodrich, K.; Torbert, R. B.; Argall, M. R.; Nakamura, R.

    2015-12-01

    The four spacecraft of the NASA Magnetospheric Multiscale mission (MMS) were launched on 12 March 2015 into a 1.2 x 12 Re equatorial orbit to study energy conversion processes in Earth's magnetosphere. After a 5-month commissioning period the first scientific phase starts on 1 September as the orbit enters the dusk magnetopause region. The Spin-plane Double Probe electric field instrument (SDP), part of the electric and magnetic fields instrument suite FIELDS, measures the electric field in the range 0.3 - 500 mV/m with a continuous time resolution up to 8192 samples/s. The instrument features adjustable bias currents and guard voltages to optimize the measurement performance. SDP also measures the spacecraft potential, which can be controlled by the Active Spacecraft Potential Control (ASPOC) ion emitter, and under certain conditions can be used to determine plasma density. We present observations of DC and AC electric fields in different plasma regions covered by MMS since launch including the night side flow braking region, reconnection regions at the dusk and dayside magnetopause, and in the magnetosheath. We compare the electric field measurements by SDP to other, independent determinations of the electric field, in particular by the Electron Drift Instrument (EDI), in order to assess the accuracy of the electric field measurement under different plasma conditions. We also study the influence of the currents emitted by ASPOC and EDI on the SDP measurements.

  6. The source of the electric field in the nightside magnetosphere

    NASA Technical Reports Server (NTRS)

    Stern, D. P.

    1975-01-01

    In the open magnetosphere model magnetic field lines from the polar caps connect to the interplanetary magnetic field and conduct an electric field from interplanetary space to the polar ionosphere. By examining the magnetic flux involved it is concluded that only slightly more than half of the magnetic flux in the polar caps belongs to open field lines and that such field lines enter or leave the magnetosphere through narrow elongated windows stretching the tail. These window regions are identified with the tail's boundary region and shift their position with changes in the interplanetary magnetic field, in particular when a change of interplanetary magnetic sector occurs. The circuit providing electric current in the magnetopause and the plasma sheet is extended across those windows; thus energy is drained from the interplanetary electric field and an electric potential drop is produced across the plasma sheet. The polar cap receives its electric field from interplanetary space on the day side from open magnetic field lines and on the night side from closed field lines leading to the plasma sheet. The theory described provides improved understanding of magnetic flux bookkeeping, of the origin of Birkeland currents, and of the boundary layer of the geomagnetic tail.

  7. Electric Fields, Cloud Microphysics, and Reflectivity in Anvils of Florida Thunderstorms

    NASA Technical Reports Server (NTRS)

    Dye, J. E.; Bateman, M. G.; Christian, H. J.; Defer, E.; Grainger, C. A.; Hall, W. D.; Krider, E. P.; Lewis, S. A.; Mach, D. M.; Merceret, F. J.; hide

    2007-01-01

    A coordinated aircraft - radar project that investigated the electric fields, cloud microphysics and radar reflectivity of thunderstorm anvils near Kennedy Space Center is described. Measurements from two cases illustrate the extensive nature of the microphysics and electric field observations. As the aircraft flew from the edges of anvils into the interior, electric fields very frequently increased abruptly from approximately 1 to more than 10 kV m(exp -1) even though the particle concentration and radar reflectivity increased smoothly. The abrupt increase in field usually occurred when the aircraft entered regions with a reflectivity of 10 to 15 dBZ. It is suggested that the abrupt increase in electric field may be because the charge advection from the storm core did not occur across the entire breadth of the anvil and was not constant in time. Screening layers were not detected near the edges of the anvils. Some long-lived anvils showed subsequent enhancement of electric field and reflectivity and growth of particles, which if localized, might be a factor in explaining the abrupt change of field in some cases. Comparisons of electric field magnitude with particle concentration or reflectivity for a combined data set that included all anvil measurements showed a threshold behavior. When the average reflectivity, such as in a 3-km cube, was less than approximately 5 dBZ, the electric field magnitude was les than kV m(exp -1). Based on these findings, the Volume Averaged Height Integrated Radar Reflectivity (VAHIRR) is now being used by NASA, the Air Force and Federal Aviation Administration in new Lightning Launch Commit Criteria as a diagnostic for high electric fields in anvils.

  8. Global electric field determination in the Earth's outer magnetosphere using energetic charged particles

    NASA Technical Reports Server (NTRS)

    Eastman, Timothy E.; Sheldon, R.; Hamilton, D.

    1995-01-01

    Although many properties of the Earth's magnetosphere have been measured and quantified in the past 30 years since it was discovered, one fundamental measurement (for zeroth order MHD equilibrium) has been made infrequently and with poor spatial coverage - the global electric field. This oversight is due in part to the neglect of theorists. However, there is renewed interest in the convection electric field because it is now realized to be central to many magnetospheric processes, including the global MHD equilibrium, reconnection rates, Region 2 Birkeland currents, magnetosphere ionosphere coupling, ring current and radiation belt transport, substorm injections, and several acceleration mechanisms. Unfortunately the standard experimental methods have not been able to synthesize a global field (excepting the pioneering work of McIlwain's geostationary models) and we are left with an overly simplistic theoretical field, the Volland-Stern electric field model. Single point measurements of the plasmapause were used to infer the appropriate amplitudes of this model, parameterized by K(sub p). Although this result was never intended to be the definitive electric field model, it has gone nearly unchanged for 20 years. The analysis of current data sets requires a great deal more accuracy than can be provided by the Volland-Stern model. The variability of electric field shielding has not been properly addressed although effects of penetrating magnetospheric electric fields has been seen in mid-and low-latitude ionospheric data sets. The growing interest in substorm dynamics also requires a much better assessment of the electric fields responsible for particle injections. Thus we proposed and developed algorithms for extracting electric fields from particle data taken in the Earth's magnetosphere. As a test of the effectiveness of these new techniques, we analyzed data taken by the AMPTE/CCE spacecraft in equatorial orbit from 1984 to 1989.

  9. Unbalanced field RF electron gun

    DOEpatents

    Hofler, Alicia

    2013-11-12

    A design for an RF electron gun having a gun cavity utilizing an unbalanced electric field arrangement. Essentially, the electric field in the first (partial) cell has higher field strength than the electric field in the second (full) cell of the electron gun. The accompanying method discloses the use of the unbalanced field arrangement in the operation of an RF electron gun in order to accelerate an electron beam.

  10. In-channel electrochemical detection in the middle of microchannel under high electric field.

    PubMed

    Kang, Chung Mu; Joo, Segyeong; Bae, Je Hyun; Kim, Yang-Rae; Kim, Yongseong; Chung, Taek Dong

    2012-01-17

    We propose a new method for performing in-channel electrochemical detection under a high electric field using a polyelectrolytic gel salt bridge (PGSB) integrated in the middle of the electrophoretic separation channel. The finely tuned placement of a gold working electrode and the PGSB on an equipotential surface in the microchannel provided highly sensitive electrochemical detection without any deterioration in the separation efficiency or interference of the applied electric field. To assess the working principle, the open circuit potentials between gold working electrodes and the reference electrode at varying distances were measured in the microchannel under electrophoretic fields using an electrically isolated potentiostat. In addition, "in-channel" cyclic voltammetry confirmed the feasibility of electrochemical detection under various strengths of electric fields (∼400 V/cm). Effective separation on a microchip equipped with a PGSB under high electric fields was demonstrated for the electrochemical detection of biological compounds such as dopamine and catechol. The proposed "in-channel" electrochemical detection under a high electric field enables wider electrochemical detection applications in microchip electrophoresis.

  11. The tunable mechanical property of water-filled carbon nanotubes under an electric field

    NASA Astrophysics Data System (ADS)

    Ye, Hongfei; Zhang, Zhongqiang; Zhang, Hongwu; Chen, Zhen; Zong, Zhi; Zheng, Yonggang

    2014-03-01

    The spring-induced compression of water-filled carbon nanotubes (CNTs) under an electric field is investigated by molecular dynamics simulations. Due to the incompressibility and polarity of water, the mechanical property of CNTs can be tuned through filling with water molecules and applying an electric field. To explore the variation of the mechanical property of water-filled CNTs, the effects of the CNT length, the filling density and the electric field intensity are examined. The simulation results indicate that the water filling and electric field can result in a slight change in the elastic property (the elastic modulus and Poisson's ratio) of water-filled CNTs. However, the yield stress and average post-buckling stress exhibit a significant response to the water density and electric field intensity. As compared to hollow CNTs, the increment in yield stress of the water-filled CNTs under an electric field of 2.0 V Å-1 is up to 35.29%, which is even higher than that resulting from metal filling. The findings from this study provide a valuable theoretical basis for designing and fabricating the controlling units at the nanoscale.

  12. Electric Field Fluctuations in Water

    NASA Astrophysics Data System (ADS)

    Thorpe, Dayton; Limmer, David; Chandler, David

    2013-03-01

    Charge transfer in solution, such as autoionization and ion pair dissociation in water, is governed by rare electric field fluctuations of the solvent. Knowing the statistics of such fluctuations can help explain the dynamics of these rare events. Trajectories short enough to be tractable by computer simulation are virtually certain not to sample the large fluctuations that promote rare events. Here, we employ importance sampling techniques with classical molecular dynamics simulations of liquid water to study statistics of electric field fluctuations far from their means. We find that the distributions of electric fields located on individual water molecules are not in general gaussian. Near the mean this non-gaussianity is due to the internal charge distribution of the water molecule. Further from the mean, however, there is a previously unreported Bjerrum-like defect that stabilizes certain large fluctuations out of equilibrium. As expected, differences in electric fields acting between molecules are gaussian to a remarkable degree. By studying these differences, though, we are able to determine what configurations result not only in large electric fields, but also in electric fields with long spatial correlations that may be needed to promote charge separation.

  13. Electric Mars: A Large Trans-Terminator Electric Potential Drop on Closed Magnetic Field Lines Above Utopia Planitia

    NASA Technical Reports Server (NTRS)

    Collinson, Glyn; Mitchell, David; Xu, Shaosui; Glocer, Alex; Grebowsky, Joseph; Hara, Takuya; Lillis, Robert; Espley, Jared; Mazelle, Christian; Sauvaud, Jean-Andre

    2017-01-01

    Abstract Parallel electric fields and their associated electric potential structures play a crucial role inionospheric-magnetospheric interactions at any planet. Although there is abundant evidence that parallel electric fields play key roles in Martian ionospheric outflow and auroral electron acceleration, the fields themselves are challenging to directly measure due to their relatively weak nature. Using measurements by the Solar Wind Electron Analyzer instrument aboard the NASA Mars Atmosphere and Volatile EvolutioN(MAVEN) Mars Scout, we present the discovery and measurement of a substantial (Phi) Mars 7.7 +/-0.6 V) parallel electric potential drop on closed magnetic field lines spanning the terminator from day to night above the great impact basin of Utopia Planitia, a region largely free of crustal magnetic fields. A survey of the previous 26 orbits passing over a range of longitudes revealed similar signatures on seven orbits, with a mean potential drop (Phi) Mars of 10.9 +/- 0.8 V, suggestive that although trans-terminator electric fields of comparable strength are not ubiquitous, they may be common, at least at these northerly latitudes.

  14. Electric field measurement in the dielectric tube of helium atmospheric pressure plasma jet

    NASA Astrophysics Data System (ADS)

    Sretenović, Goran B.; Guaitella, Olivier; Sobota, Ana; Krstić, Ivan B.; Kovačević, Vesna V.; Obradović, Bratislav M.; Kuraica, Milorad M.

    2017-03-01

    The results of the electric field measurements in the capillary of the helium plasma jet are presented in this article. Distributions of the electric field for the streamers are determined for different gas flow rates. It is found that electric field strength in front of the ionization wave decreases as it approaches to the exit of the tube. The values obtained under presented experimental conditions are in the range of 5-11 kV/cm. It was found that the increase in gas flow above 1500 SCCM could induce substantial changes in the discharge operation. This is reflected through the formation of the brighter discharge region and appearance of the electric field maxima. Furthermore, using the measured values of the electric field strength in the streamer head, it was possible to estimate electron densities in the streamer channel. Maximal density of 4 × 1011 cm-3 is obtained in the vicinity of the grounded ring electrode. Similar behaviors of the electron density distributions to the distributions of the electric field strength are found under the studied experimental conditions.

  15. Influence of an external electric field on the potential-energy surface of alkali-metal-decorated C60

    NASA Astrophysics Data System (ADS)

    De, Deb Sankar; Saha, Santanu; Genovese, Luigi; Goedecker, Stefan

    2018-06-01

    We present a fully ab initio, unbiased structure search of the configurational space of decorated C60 fullerenes in the presence of an electric field. We observed that the potential-energy surface is significantly perturbed by an external electric field and that the energetic ordering of low-energy isomers differs with and without electric field. We identify the energetically lowest configuration for a varying number of decorating atoms (1 ≤n ≤12 ) for Li and (1 ≤n ≤6 ) for K on the C60 surface at different electric-field strengths. Using the correct geometric ground state in the electric field for the calculation of the dipole we obtain better agreement with the experimentally measured values than previous calculations based on the ground state in absence of an electric field. Since the lowest-energy structures are typically nearly degenerate in energy, a combination of different structures is expected to be found at room temperature. The experimentally measured dipole is therefore also expected to contain significant contributions from several low-energy structures.

  16. The Vector Electric Field Instrument on the C/NOFS Satellite

    NASA Technical Reports Server (NTRS)

    Pfaff, R.; Kujawski, J.; Uribe, P.; Bromund, K.; Fourre, R.; Acuna, M.; Le, G.; Farrell, W.; Holzworth, R.; McCarthy, M.; hide

    2008-01-01

    We provide an overview of the Vector Electric Field Instrument (VEFI) on the Air Force Communication/Navigation Outage Forecasting System (C/NOFS) satellite, a mission designed to understand, model, and forecast the presence of equatorial ionospheric irregularities. VEFI is a NASA GSFC instrument designed 1) to investigate the role of the ambient electric fields in initiating nighttime ionospheric density depletions and turbulence; 2) to determine the electric fields associated with abrupt, large amplitude, density depletions and 3) to quantify the spectrum of the wave electric fields and plasma densities (irregularities) associated with density depletions or Equatorial Spread-F. The VEFI instrument includes a vector electric field double probe detector, a Langmuir trigger probe, a flux gate magnetometer, a lightning detector and associated electronics. The heart of the instrument is the set of double probe detectors designed to measure DC and AC electric fields using 6 identical, mutually orthogonal, deployable 9.5 m booms tipped with 10 cm diameter spheres containing embedded preamplifiers. A description of the instrument and its sensors will be presented. If available, representative measurements will be provided.

  17. The Electric Field of a Weakly Electric Fish

    NASA Astrophysics Data System (ADS)

    Rasnow, Brian K.

    Freshwater fish of the genus Apteronotus (family Gymnotidae) generate a weak, high frequency electric field (<100 mV/cm, 0.5-10 kHz) which permeates their local environment. These nocturnal fish are acutely sensitive to perturbations in their electric field caused by other electric fish, and nearby objects whose impedance is different from the surrounding water. This thesis presents high temporal and spatial resolution maps of the electric potential and field on and near Apteronotus. The fish's electric field is a complicated and highly stable function of space and time. Its characteristics, such as spectral composition, timing, and rate of attenuation, are examined in terms of physical constraints, and their possible functional roles in electroreception. Temporal jitter of the periodic field is less than 1 musec. However, electrocyte activity is not globally synchronous along the fish's electric organ. The propagation of electrocyte activation down the fish's body produces a rotation of the electric field vector in the caudal part of the fish. This may assist the fish in identifying nonsymmetrical objects, and could also confuse electrosensory predators that try to locate Apteronotus by following its fieldlines. The propagation also results in a complex spatiotemporal pattern of the EOD potential near the fish. Visualizing the potential on the same and different fish over timescales of several months suggests that it is stable and could serve as a unique signature for individual fish. Measurements of the electric field were used to calculate the effects of simple objects on the fish's electric field. The shape of the perturbation or "electric image" on the fish's skin is relatively independent of a simple object's size, conductivity, and rostrocaudal location, and therefore could unambiguously determine object distance. The range of electrolocation may depend on both the size of objects and their rostrocaudal location. Only objects with very large dielectric constants cause appreciable phase shifts, and these are strongly dependent on the water conductivity.

  18. Dynamical Generation of Quasi-Stationary Alfvenic Double Layers and Charge Holes and Unified Theory of Quasi-Static and Alfvenic Auroral Arc Formation

    NASA Astrophysics Data System (ADS)

    Song, Y.; Lysak, R. L.

    2015-12-01

    Parallel E-fields play a crucial role for the acceleration of charged particles, creating discrete aurorae. However, once the parallel electric fields are produced, they will disappear right away, unless the electric fields can be continuously generated and sustained for a fairly long time. Thus, the crucial question in auroral physics is how to generate such a powerful and self-sustained parallel electric fields which can effectively accelerate charge particles to high energy during a fairly long time. We propose that nonlinear interaction of incident and reflected Alfven wave packets in inhomogeneous auroral acceleration region can produce quasi-stationary non-propagating electromagnetic plasma structures, such as Alfvenic double layers (DLs) and Charge Holes. Such Alfvenic quasi-static structures often constitute powerful high energy particle accelerators. The Alfvenic DL consists of localized self-sustained powerful electrostatic electric fields nested in a low density cavity and surrounded by enhanced magnetic and mechanical stresses. The enhanced magnetic and velocity fields carrying the free energy serve as a local dynamo, which continuously create the electrostatic parallel electric field for a fairly long time. The generated parallel electric fields will deepen the seed low density cavity, which then further quickly boosts the stronger parallel electric fields creating both Alfvenic and quasi-static discrete aurorae. The parallel electrostatic electric field can also cause ion outflow, perpendicular ion acceleration and heating, and may excite Auroral Kilometric Radiation.

  19. One-step fabrication of nanostructure-covered microstructures using selective aluminum anodization based on non-uniform electric field

    NASA Astrophysics Data System (ADS)

    Park, Yong Min; Kim, Byeong Hee; Seo, Young Ho

    2016-06-01

    This paper presents a selective aluminum anodization technique for the fabrication of microstructures covered by nanoscale dome structures. It is possible to fabricate bulging microstructures, utilizing the different growth rates of anodic aluminum oxide in non-uniform electric fields, because the growth rate of anodic aluminum oxide depends on the intensity of electric field, or current density. After anodizing under a non-uniform electric field, bulging microstructures covered by nanostructures were fabricated by removing the residual aluminum layer. The non-uniform electric field induced by insulative micropatterns was estimated by computational simulations and verified experimentally. Utilizing computational simulations, the intensity profile of the electric field was calculated according to the ratio of height and width of the insulative micropatterns. To compare computational simulation results and experimental results, insulative micropatterns were fabricated using SU-8 photoresist. The results verified that the shape of the bottom topology of anodic alumina was strongly dependent on the intensity profile of the applied electric field, or current density. The one-step fabrication of nanostructure-covered microstructures can be applied to various fields, such as nano-biochip and nano-optics, owing to its simplicity and cost effectiveness.

  20. Electrostatic risk to reticles in the nanolithography era

    NASA Astrophysics Data System (ADS)

    Rider, Gavin C.

    2016-04-01

    Reticles can be damaged by electric field as well as by the conductive transfer of charge. As device feature sizes have moved from the micro- into the nano-regime, reticle sensitivity to electric field has been increasing owing to the physics of field induction. Hence, the predominant risk to production reticles today is from exposure to electric field. Measurements of electric field that illustrate the extreme risk faced by today's production reticles are presented. It is shown that some of the standard methods used for prevention of electrostatic discharge in semiconductor manufacturing, being based on controlling static charge and voltage, do not offer reticles adequate protection against electric field. In some cases, they actually increase the risk of reticle damage. Methodology developed specifically to protect reticles against electric field is required, which is described in SEMI Standard E163. Measurements are also presented showing that static dissipative plastic is not an ideal material to use for the construction of reticle pods as it both generates and transmits transient electric field. An appropriate combination of insulating material and metallic shielding is shown to provide the best electrostatic protection for reticles, with fail-safe protection only being possible if the reticle is fully shielded within a metal Faraday cage.

  1. Calculations of low-frequency radio emission by cosmic-ray-induced particle showers

    NASA Astrophysics Data System (ADS)

    García-Fernández, Daniel; Revenu, Benoît; Charrier, Didier; Dallier, Richard; Escudie, Antony; Martin, Lilian

    2018-05-01

    The radio technique for the detection of high-energy cosmic rays consists in measuring the electric field created by the particle showers created inside a medium by the primary cosmic ray. The electric field is then used to infer the properties of the primary particle. Nowadays, the radio technique is a standard, well-established technique. While most current experiments measure the field at frequencies above 20 MHz, several experiments have reported a large emission at low frequencies, below 10 MHz. The EXTASIS experiment aims at measuring again and understanding this low-frequency electric field. Since at low frequencies the standard far-field approximation for the calculation of the electric field does not necessarily hold, in order to comprehend the low-frequency emission we need to go beyond the far-field approximation. We present in this work a formula for the electric field created by a particle track inside a dielectric medium that is valid for all frequencies. We then implement this formula in the SELFAS Monte Carlo code and calculate the low-frequency electric field of the extensive air shower (EAS). We also study the electric field of a special case of the transition radiation mechanism when the EAS particles cross the air-soil boundary. We introduce the sudden death pulse, the direct emission caused by the coherent deceleration of the shower front at the boundary, as a first approximation to the whole electric field for the air-soil transition, and study its properties. We show that at frequencies larger than 20 MHz and distances larger than 100 m, the standard far-field approximation for the horizontal polarizations of the field is always accurate at the 1% level.

  2. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Toriello, Nicholas M.; Douglas, Erik S.; Mathies, Richard A.

    A microchip that performs directed capture and chemical activation of surface-modified single-cells has been developed. The cell-capture system is comprised of interdigitated gold electrodes microfabricated on a glass substrate within PDMS channels. The cell surface is labeled with thiol functional groups using endogenous RGD receptors and adhesion to exposed gold pads on the electrodes is directed by applying a driving electric potential. Multiple cell types can thus be sequentially and selectively captured on desired electrodes. Single-cell capture efficiency is optimized by varying the duration of field application. Maximum single-cell capture is attained for the 10 min trial, with 63+-9 percentmore » (n=30) of the electrode pad rows having a single cell. In activation studies, single M1WT3 CHO cells loaded with the calcium-sensitive dye fluo-4 AM were captured; exposure to the muscarinic agonist carbachol increased the fluorescence to 220+-74percent (n=79) of the original intensity. These results demonstrate the ability to direct the adhesion of selected living single cells on electrodes in a microfluidic device and to analyze their response to chemical stimuli.« less

  3. Electric Field Controlled Magnetism in BiFeO3/Ferromagnet Films

    NASA Astrophysics Data System (ADS)

    Holcomb, M. B.; Chu, Y. H.; Martin, L. W.; Gajek, M.; Seidel, J.; Ramesh, R.; Scholl, A.; Fraile-Rodriguez, A.

    2008-03-01

    Electric field control of magnetism is a hot technological topic at the moment due to its potential to revolutionize today's devices. Magnetoelectric materials, those having both electric and magnetic order and the potential for coupling between the two, are a promising avenue to approach electric control. BiFeO3, both a ferroelectric and an antiferromagnet, is the only single phase room temperature magnetoelectric that is currently known. In addition to other possibilities, its multiferroic nature has potential in the very active field of exchange bias, where an antiferromagnetic thin film pins the magnetic direction of an adjoining ferromagnetic layer. Since this antiferromagnet is electrically tunable, this coupling could allow electric-field control of the ferromagnetic magnetization. Direction determination of antiferromagnetic domains in BFO has recently been shown using linear and circular dichroism studies. Recently, this technique has been extended to look at the magnetic domains of a ferromagnetic grown on top of BFO. The clear magnetic changes induced by application of electric fields reveal the possibility of electric control.

  4. Flexible gas insulated transmission line having regions of reduced electric field

    DOEpatents

    Cookson, Alan H.; Fischer, William H.; Yoon, Kue H.; Meyer, Jeffry R.

    1983-01-01

    A gas insulated transmission line having radially flexible field control means for reducing the electric field along the periphery of the inner conductor at predetermined locations wherein the support insulators are located. The radially flexible field control means of the invention includes several structural variations of the inner conductor, wherein careful controlling of the length to depth of surface depressions produces regions of reduced electric field. Several embodiments of the invention dispose a flexible connector at the predetermined location along the inner conductor where the surface depressions that control the reduced electric field are located.

  5. Simultaneous electric-field measurements on nearby balloons.

    NASA Technical Reports Server (NTRS)

    Mozer, F. S.

    1972-01-01

    Electric-field payloads were flown simultaneously on two balloons from Great Whale River, Canada, on September 21, 1971, to provide data at two points in the upper atmosphere that differed in altitude by more than one atmospheric density scale height and in horizontal position by 30-140 km. The altitude dependences in the two sets of data prove conclusively that the vertical electric field at balloon altitudes stems from fair-weather atmospheric electricity sources and that the horizontal fields are mapped down ionospheric fields, since the weather-associated horizontal fields were smaller than 2 mV/m.

  6. COMSOL based Simulation on the Effect of Electric Field changes due to Lightning on Ground

    NASA Astrophysics Data System (ADS)

    Premlet, B.; Joby, N. E.; Sabu, S.

    2017-12-01

    The phenomenon of lightning is accompanied by localised changes in atmospheric electric fields. In cloud-to-ground strike locations, changes in atmospheric electric fields can even be observed at the ground a few minutes prior to a strike. A lot of research has been done already on the electrostatic changes prior to lightning in the region above ground. Through this work, we investigate into the effects of lightning electric fields on/under ground with the aid of simulations done in COMSOL Multiphysics. Horizontal and vertical profiles of voltage gradient, electric field, polarisation etc. are investigated. Simulation experiments were conducted using a general model of lightning electric fields formed using data recorded by the Electric Field Mills(EFMs) from three diverse parts of the world- Kennedy Space Centre (KSC),Florida (Using GHRC datasets),Sonnblick Observatory, Austria and National Centre for Earth Science Studies Trivandrum (NCESS),India. COMSOL models of the global electric circuit were developed using Sandstone as the base model for ground. Similar works in literature have only dealt with lightning electric fields above the ground. This work is the first step towards a high-level simulation on the effects of atmospheric electric field on/below ground. The results of this simulation work can aid lightning forecasting and preparedness by opening new doors for voltage based prediction methods at ground. It is also a tool to understand phenomena such as fulgurites, corona effect etc. It also helps in the design of buried cables and improved grounding systems. This work can also be a first step towards understanding localised potential variations at the ground during lightning.

  7. Organic magnetic field sensor

    DOEpatents

    McCamey, Dane; Boehme, Christoph

    2017-01-24

    An organic, spin-dependent magnetic field sensor (10) includes an active stack (12) having an organic material with a spin-dependence. The sensor (10) also includes a back electrical contact (14) electrically coupled to a back of the active stack (12) and a front electrical contact (16) electrically coupled to a front of the active stack (12). A magnetic field generator (18) is oriented so as to provide an oscillating magnetic field which penetrates the active stack (12).

  8. Electric field numerical simulation of disc type electrostatic spinning spinneret

    NASA Astrophysics Data System (ADS)

    Wei, L.; Deng, ZL; Qin, XH; Liang, ZY

    2018-01-01

    Electrospinning is a new type of free-end spinning built on electric field. Different from traditional single needle spinneret, in this study, a new disc type free surface spinneret is used to produce multiple jets, this will greatly improve production efficiency of nanofiber. The electric-field distribution of spinneret is the crux of the formation and trajectory of jets. In order to probe the electric field intensity of the disc type spinneret, computational software of Ansoft Maxwell 12 is adopted for a precise and intuitive analysis. The results showed that the whole round cambered surface of the spinning solution at edge of each layer of the spinneret with the maximum curvature has the highest electric field intensity, and through the simulation of the electric field distribution of different spinneret parameters such as layer, the height and radius of the spinneret. Influences of various parameters on the electrostatic spinning are obtained.

  9. Acceleration of metal-atom diffusion in electric field at metal/insulator interfaces: First-principles study

    NASA Astrophysics Data System (ADS)

    Nagasawa, Riki; Asayama, Yoshihiro; Nakayama, Takashi

    2018-04-01

    Metal-atom diffusion from metal electrodes into SiO2 in electric fields was studied using first-principles calculations. It was shown in the case without electric field that the diffusion barrier of a metal atom is mainly made of the cohesive energy of bulk metal layers, while the shape of the diffusion potential reflects the hybridization of the metal-atom state with metal-induced gap states (MIGSs) and the electron transfer between the metal atom and the electrode. We found that the metal-atom diffusion is markedly accelerated by the applied electric field, such that the diffusion barrier ϕB(E) decreases almost linearly with increasing electric field strength E. By analyzing the physical origins of the metal-atom diffusion, we derived the universal formula to estimate the diffusion barrier in the electric field, which is closely related to MIGSs.

  10. Electro-optical properties of zigzag and armchair boron nitride nanotubes under a transverse electric field: Tight binding calculations

    NASA Astrophysics Data System (ADS)

    Chegel, Raad; Behzad, Somayeh

    2012-02-01

    The electro-optical properties of zigzag and armchair BNNTs in a uniform transverse electric field are investigated within tight binding approximation. It is found that the electric field modifies the band structure and splits band degeneracy where these effects reflect in the DOS and JDOS spectra. A decrease in the band gap, as a function of the electric field, is observed. This gap reduction increases with the diameter and it is independent of chirality. An analytic function to estimate the electric field needed for band gap closing is proposed which is in good agreement with DFT results. In additional, we show that the larger diameter tubes are more sensitive than small ones. Number and position of peaks in DOS and JDOS spectra for armchair and zigzag tubes with similar radius are dependent on electric field strength.

  11. Electric fields in the plasma sheet and plasma sheet boundary layer

    NASA Technical Reports Server (NTRS)

    Pedersen, A.; Knott, K.; Cattell, C. A.; Mozer, F. S.; Falthammar, C.-G.; Lindqvist, P.-A.; Manka, R. H.

    1985-01-01

    Results obtained by Forbes et al. (1981) on the basis of time delay measurements between ISEE 1 and ISEE 2 imply that the plasma flow and the boundary contracting velocity were nearly the same, whereas the expanding boundary velocity was not accompanied by any significant plasma sheet plasma motion. In the present study, this observation is discussed in conjunction with electric field data. The study is based on electric field data from the spherical double probe experiment on ISEE 1. Electric field data from GEOS 2 are used to some extent to monitor the electric fields near the geostationary orbit during the considered eve nts. Electric field data during CDAW 6 events are discussed, taking into account positions of ISEE 1/ISEE 2 and GEOS 2; March 22, 0600-1300 UT; and March 22, UT; and March 31, 1400-2400 UT.

  12. Effects of electric field and light polarization on the electromagnetically induced transparency in an impurity doped quantum ring

    NASA Astrophysics Data System (ADS)

    Bejan, D.; Stan, C.; Niculescu, E. C.

    2018-01-01

    We theoretically investigated the effects of the impurity position, in-plane electric field, intensity and polarization of the probe and control lasers on the electromagnetically induced transparency (EIT) in GaAs/GaAlAs disc shaped quantum ring. Our study reveals that, depending on the impurity position, the quantum system presents two specific configurations for the EIT occurrence even in the absence of the external electric field, i.e. ladder-configuration or V-configuration, and changes the configuration from ladder to V for specific electric field values. The polarization of the probe and control lasers plays a crucial role in obtaining a good transparency. The electric field controls the red-shift (blue-shift) of the transparency window and modifies its width. The system exhibits birefringence for the probe light in a limited interval of electric field values.

  13. Indirect determination of the electric field in plasma discharges using laser-induced fluorescence spectroscopy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vaudolon, J., E-mail: julien.vaudolon@cnrs-orleans.fr; Mazouffre, S., E-mail: stephane.mazouffre@cnrs-orleans.fr

    2014-09-15

    The evaluation of electric fields is of prime interest for the description of plasma characteristics. In this work, different methods for determining the electric field profile in low-pressure discharges using one- and two-dimensional Laser-Induced Fluorescence (LIF) measurements are presented and discussed. The energy conservation, fluid, and kinetic approaches appear to be well-suited for the electric field evaluation in this region of the plasma flow. However, the numerical complexity of a two-dimensional kinetic model is penalizing due to the limited signal-to-noise ratio that can be achieved, making the computation of the electric field subject to large error bars. The ionization contributionmore » which appears in the fluid model makes it unattractive on an experimental viewpoint. The energy conservation and 1D1V kinetic approaches should therefore be preferred for the determination of the electric field when LIF data are used.« less

  14. Deformation analysis of vesicles in an alternating-current electric field.

    PubMed

    Tang, Yu-Gang; Liu, Ying; Feng, Xi-Qiao

    2014-08-01

    In this paper the shape equation for axisymmetric vesicles subjected to an ac electric field is derived on the basis of the liquid-crystal model. The equilibrium morphology of a lipid vesicle is determined by the minimization of its free energy in coupled mechanical and ac electric fields. Besides elastic bending, the effects of the osmotic pressure difference, surface tension, Maxwell pressure, and flexoelectric and dielectric properties of phospholipid membrane as well are taken into account. The influences of elastic bending, osmotic pressure difference, and surface tension on the frequency-dependent behavior of a vesicle membrane in an ac electric field are examined. The singularity of the ac electric field is also investigated. Our theoretical results of vesicle deformation agree well with previous experimental and numerical results. The present study provides insights into the physical mechanisms underpinning the frequency-dependent morphological evolution of vesicles in the electric and mechanical fields.

  15. Endogenous opiates and behavior: 2001.

    PubMed

    Bodnar, Richard J; Hadjimarkou, Maria M

    2002-12-01

    This paper is the twenty-fourth installment of the annual review of research concerning the opiate system. It summarizes papers published during 2001 that studied the behavioral effects of the opiate peptides and antagonists. The particular topics covered this year include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (Section 2), and the roles of these opioid peptides and receptors in pain and analgesia (Section 3); stress and social status (Section 4); tolerance and dependence (Section 5); learning and memory (Section 6); eating and drinking (Section 7); alcohol and drugs of abuse (Section 8); sexual activity and hormones, pregnancy, development and endocrinology(Section 9); mental illness and mood (Section 10); seizures and neurologic disorders (Section 11); electrical-related activity and neurophysiology (Section 12); general activity and locomotion (Section 13); gastrointestinal, renal and hepatic functions (Section 14); cardiovascular responses (Section 15); respiration and thermoregulation (Section 16); and immunological responses (Section 17).

  16. Response of ionospheric electric fields at mid-low latitudes during geomagnetic sudden commencements

    NASA Astrophysics Data System (ADS)

    Takahashi, N.; Kasaba, Y.; Shinbori, A.; Nishimura, Y.; Kikuchi, T.; Ebihara, Y.; Nagatsuma, T.

    2014-12-01

    Geomagnetic sudden commencements (SCs) are known as one of the distinct magnetospheric disturbance phenomena triggered by solar wind disturbances. Many previous studies have focused on the generation mechanism of SCs by using in-situ observations and simulations. However, the global evolution of ionospheric electric fields has primarily been estimated from the ionospheric current. Although a few studies utilized electric field data from radar observations, the coverage is limited in time, and limited component of the electric field is obtained. In this study, we investigated the response and local time dependence of the ionospheric electric field at mid-low latitudes associated with 203 SCs occurred from 1999 to 2004 by the in-situ observation of the ROCSAT-1 spacecraft. We found that the ionospheric electric field associated with SCs instantaneously responds to geomagnetic fields regardless of spacecraft local time. Our statistical analysis also showed the instantaneous response of the electric field, which indicates the global instant transmission of the electric field from polar region. In contrast, peak times in the preliminary impulse (PI) and main impulse (MI) phases were different between the ionospheric electric field and equatorial geomagnetic field (20 sec in the PI phase). Based on a comparison to the ground-ionosphere waveguide model by Kikuchi [2014], this time lag is suggested to be due to the latitudinal difference of the ionospheric conductivity. After constructing the local time distribution of the SC amplitude, we found that the dayside feature was seen at 18-22 h even the ionospheric conductivity is lower than that at dayside. We performed a magnetohydrodynamic (MHD) simulation for an ideal SC. The result of the simulation showed that the electric potential distribution is asymmetric with respect to the noon-midnight meridian, which is similar to our observational result. It appears to result from the divergence of the Hall current under the non-uniform ionospheric conductivity near the terminator as well as the auroral region.

  17. Effects of electric and magnetic fields on the electronic properties of zigzag carbon and boron nitride nanotubes

    NASA Astrophysics Data System (ADS)

    Chegel, Raad; Behzad, Somayeh; Ahmadi, Eghbal

    2012-04-01

    We have investigated the electronic properties of zigzag CNTs and BNNTs under the external transverse electric field and axial magnetic field, using tight binding approximation. It was found that after switching on the electric and magnetic fields, the band modification such as distortion of the degeneracy, change in energy dispersion, subband spacing and band gap size reduction occurs. The band gap of zigzag BNNTs decreases linearly with increasing the electric field strength but the band gap variation for CNTs increases first and later decreases (Metallic) or first hold constant and then decreases (semiconductor). For type (II) CNTs, at a weak magnetic field, by increasing the electric field strength, the band gap remains constant first and then decreases and in a stronger magnetic field the band gap reduction becomes parabolic. For type (III) CNTs, in any magnetic field, the band gap increases slowly until reaches a maximum value and then decreases linearly. Unlike to CNTs, the magnetic field has less effects on the BNNTs band gap variation.

  18. Generalized theoretical method for the interaction between arbitrary nonuniform electric field and molecular vibrations: Toward near-field infrared spectroscopy and microscopy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Iwasa, Takeshi, E-mail: tiwasa@mail.sci.hokudai.ac.jp; Takenaka, Masato; Taketsugu, Tetsuya

    A theoretical method to compute infrared absorption spectra when a molecule is interacting with an arbitrary nonuniform electric field such as near-fields is developed and numerically applied to simple model systems. The method is based on the multipolar Hamiltonian where the light-matter interaction is described by a spatial integral of the inner product of the molecular polarization and applied electric field. The computation scheme is developed under the harmonic approximation for the molecular vibrations and the framework of modern electronic structure calculations such as the density functional theory. Infrared reflection absorption and near-field infrared absorption are considered as model systems.more » The obtained IR spectra successfully reflect the spatial structure of the applied electric field and corresponding vibrational modes, demonstrating applicability of the present method to analyze modern nanovibrational spectroscopy using near-fields. The present method can use arbitral electric fields and thus can integrate two fields such as computational chemistry and electromagnetics.« less

  19. Generalized theoretical method for the interaction between arbitrary nonuniform electric field and molecular vibrations: Toward near-field infrared spectroscopy and microscopy.

    PubMed

    Iwasa, Takeshi; Takenaka, Masato; Taketsugu, Tetsuya

    2016-03-28

    A theoretical method to compute infrared absorption spectra when a molecule is interacting with an arbitrary nonuniform electric field such as near-fields is developed and numerically applied to simple model systems. The method is based on the multipolar Hamiltonian where the light-matter interaction is described by a spatial integral of the inner product of the molecular polarization and applied electric field. The computation scheme is developed under the harmonic approximation for the molecular vibrations and the framework of modern electronic structure calculations such as the density functional theory. Infrared reflection absorption and near-field infrared absorption are considered as model systems. The obtained IR spectra successfully reflect the spatial structure of the applied electric field and corresponding vibrational modes, demonstrating applicability of the present method to analyze modern nanovibrational spectroscopy using near-fields. The present method can use arbitral electric fields and thus can integrate two fields such as computational chemistry and electromagnetics.

  20. Electro- and Magneto-Modulated Ion Transport through Graphene Oxide Membranes

    PubMed Central

    Sun, Pengzhan; Zheng, Feng; Wang, Kunlin; Zhong, Minlin; Wu, Dehai; Zhu, Hongwei

    2014-01-01

    The control of ion trans-membrane transport through graphene oxide (GO) membranes is achieved by electric and magnetic fields. Electric field can either increase or decrease the ion transport through GO membranes depending on its direction, and magnetic field can enhance the ion penetration monotonically. When electric field is applied across GO membrane, excellent control of ion fluidic flows can be done. With the magnetic field, the effective anchoring of ions is demonstrated but the modulation of the ion flowing directions does not occur. The mechanism of the electro- and magneto-modulated ion trans-membrane transport is investigated, indicating that the electric fields dominate the ion migration process while the magnetic fields tune the structure of nanocapillaries within GO membranes. Results also show that the ion selectivity of GO membranes can be tuned with the electric fields while the transport of ions can be enhanced synchronously with the magnetic fields. These excellent properties make GO membranes promising in areas such as field-induced mass transport control and membrane separation. PMID:25347969

  1. Analysis of electric field distribution in GaAs metal-semiconductor field effect transistor with a field-modulating plate

    NASA Astrophysics Data System (ADS)

    Hori, Yasuko; Kuzuhara, Masaaki; Ando, Yuji; Mizuta, Masashi

    2000-04-01

    Electric field distribution in the channel of a field effect transistor (FET) with a field-modulating plate (FP) has been theoretically investigated using a two-dimensional ensemble Monte Carlo simulation. This analysis revealed that the introduction of FP is effective in canceling the influence of surface traps under forward bias conditions and in reducing the electric field intensity at the drain side of the gate edge under pinch-off bias conditions. This study also found that a partial overlap of the high-field region under the gate and that at the FP electrode is important for reducing the electric field intensity. The optimized metal-semiconductor FET with FP (FPFET) (LGF˜0.2 μm) exhibited a much lower peak electric field intensity than a conventional metal-semiconductor FET. Based on these numerically calculated results, we have proposed a design procedure to optimize the power FPFET structure with extremely high breakdown voltages while maintaining reasonable gain performance.

  2. Temporal evolution of the electric field accelerating electrons away from the auroral ionosphere.

    PubMed

    Marklund, G T; Ivchenko, N; Karlsson, T; Fazakerley, A; Dunlop, M; Lindqvist, P A; Buchert, S; Owen, C; Taylor, M; Vaivalds, A; Carter, P; André, M; Balogh, A

    2001-12-13

    The bright night-time aurorae that are visible to the unaided eye are caused by electrons accelerated towards Earth by an upward-pointing electric field. On adjacent geomagnetic field lines the reverse process occurs: a downward-pointing electric field accelerates electrons away from Earth. Such magnetic-field-aligned electric fields in the collisionless plasma above the auroral ionosphere have been predicted, but how they could be maintained is still a matter for debate. The spatial and temporal behaviour of the electric fields-a knowledge of which is crucial to an understanding of their nature-cannot be resolved uniquely by single satellite measurements. Here we report on the first observations by a formation of identically instrumented satellites crossing a beam of upward-accelerated electrons. The structure of the electric potential accelerating the beam grew in magnitude and width for about 200 s, accompanied by a widening of the downward-current sheet, with the total current remaining constant. The 200-s timescale suggests that the evacuation of the electrons from the ionosphere contributes to the formation of the downward-pointing magnetic-field-aligned electric fields. This evolution implies a growing load in the downward leg of the current circuit, which may affect the visible discrete aurorae.

  3. High-frequency thermal-electrical cycles for pyroelectric energy conversion

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bhatia, Bikram; Damodaran, Anoop R.; Cho, Hanna

    2014-11-21

    We report thermal to electrical energy conversion from a 150 nm thick BaTiO{sub 3} film using pyroelectric cycles at 1 kHz. A microfabricated platform enables temperature and electric field control with temporal resolution near 1 μs. The rapid electric field changes as high as 11 × 10{sup 5 }kV/cm-s, and temperature change rates as high as 6 × 10{sup 5 }K/s allow exploration of pyroelectric cycles in a previously unexplored operating regime. We investigated the effect of phase difference between electric field and temperature cycles, and electric field and temperature change rates on the electrical energy generated from thermal-electrical cycles based on the pyroelectric Ericsson cycle. Complete thermodynamic cyclesmore » are possible up to the highest cycle rates tested here, and the energy density varies significantly with phase shifts between temperature and electric field waveforms. This work could facilitate the design and operation of pyroelectric cycles at high cycle rates, and aid in the design of new pyroelectric systems.« less

  4. Measurements and models of electric fields in the in vivo human brain during transcranial electric stimulation

    PubMed Central

    Huang, Yu; Liu, Anli A; Lafon, Belen; Friedman, Daniel; Dayan, Michael; Wang, Xiuyuan; Bikson, Marom; Doyle, Werner K; Devinsky, Orrin; Parra, Lucas C

    2017-01-01

    Transcranial electric stimulation aims to stimulate the brain by applying weak electrical currents at the scalp. However, the magnitude and spatial distribution of electric fields in the human brain are unknown. We measured electric potentials intracranially in ten epilepsy patients and estimated electric fields across the entire brain by leveraging calibrated current-flow models. When stimulating at 2 mA, cortical electric fields reach 0.8 V/m, the lower limit of effectiveness in animal studies. When individual whole-head anatomy is considered, the predicted electric field magnitudes correlate with the recorded values in cortical (r = 0.86) and depth (r = 0.88) electrodes. Accurate models require adjustment of tissue conductivity values reported in the literature, but accuracy is not improved when incorporating white matter anisotropy or different skull compartments. This is the first study to validate and calibrate current-flow models with in vivo intracranial recordings in humans, providing a solid foundation to target stimulation and interpret clinical trials. DOI: http://dx.doi.org/10.7554/eLife.18834.001 PMID:28169833

  5. Measuring the vertical electrical field above an oceanic convection system using a meteorological sounding balloon

    NASA Astrophysics Data System (ADS)

    Chen, A. B.; Chiu, C.; Lai, S.; Chen, C.; Kuo, C.; Su, H.; Hsu, R.

    2012-12-01

    The vertical electric field above thundercloud plays an important role in the generation and modeling of transient luminous events. For example, Pasko [1995] proposed that the high quasi-static E-field following the positive cloud-to-ground lightning could accelerate and input energy to ambient electrons; as they collide and excite nitrogen and oxygen molecules in upper atmosphere, sprites may be induced. A series of balloon experiments led by Holzworth have investigated the temporal and spatial fluctuations of the electric field and conductivity in the upper atmosphere at different sites [Holzworth 2005, and references in]. But the strength and variation of the vertical electric field above thundercloud, especially oceanic ones, are not well documented so far. A lightweight, low-cost measurement system including an electric field meter and the associated aviation electronics are developed to carry out the in-situ measurement of the vertical electric field and the inter-cloud charge distribution. Our measuring system was first deployed using a meteorological sounding balloon from Taitung, Taiwan in May 2012. The measured electric field below 3km height shows an exponential decay and it is consistent with the expected potential gradient variation between ionosphere and the Earth surface. But the background strength of the measured E-field grows up exponentially and a violent fluctuations is also observed when the balloon flew over a developing oceanic convection cell. The preliminary results from this flight will be reported and discussed. This low-cost electric field meter is developed within one year. In the coming months, more flights will be performed with the aim to measure the rapid variation of the electric field above thundercloud as well as the E-field that may induce transient luminous events. Our ground campaigns show that the occurrence rates of blue and gigantic jet are relatively high in the vicinity of Taiwan. Our experiment can be used to diagnose the dynamics of the E-field associated with blue and gigantic jets.

  6. Electric ants: A cross-disciplinary approach to understanding insect behavior

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Slowik, T.J.; Thorvilson, H.G.; Green, B.L.

    1996-12-31

    The response and attraction of the red imported fire ant, Solenopsis invicta, to electrical equipment was examined using an interdisciplinary approach. Entomologists specializing in fire ant behavior combined expertise with electrical engineers to investigate the economically damaging interaction of fire ants with electrical circuitry. Knowledge from the realms of physics, engineering, and biology were integrated in experimentation to test for a fire ant response to electric fields and magnetic fields associated with electrical equipment. It was determined that fire ants react to electrified conductive material and the alternating-current magnetic fields associated with electricity.

  7. Bandstructure modulation for Si-h and Si-g nanotubes in a transverse electric field: Tight binding approach

    NASA Astrophysics Data System (ADS)

    Chegel, Raad; Behzad, Somayeh

    2013-11-01

    We have investigated the electronic properties of SiNTs, under the external electric field, using Tight Binding (TB) approximation. It was found that the energy levels, energy gaps, and density of states (DOS) strongly depend on the electric field strength. The large electric strength leads to coupling the neighbor subbands and induce destruction of subband degeneracy, increase of low-energy states, and strong modulation of energy gap which these effects reflect in the DOS spectrum. It has been shown that, the band gap reduction of Si g-NTs is linearly proportional to the electric field strength. The band gap variation for Si h-NTs increases first and later decreases (Metallic) or first remains constant and then decreases (semiconductor). Also we show that the larger diameter tubes are more sensitive to the field strength than smaller ones. The semiconducting metallic transition or vice versa can be achieved through an increasing of applied fields. Number and position of peaks in DOS spectrum are dependent on electric field strength.

  8. Effect of an alternating current electric field on Co(OH)2 periodic precipitation

    NASA Astrophysics Data System (ADS)

    Karam, Tony; Sultan, Rabih

    2013-02-01

    The present paper studies the effect of an alternating current (AC) electric field on Co(OH)2 Liesegang patterns. In the presence of an AC electric field, the band spacing increases with spacing number, but reaches a plateau at large spacing (or band) numbers. The band spacing increases with applied AC voltage, but to a much lesser extent than the effect of a DC electric field under the same applied voltage [see R. Sultan, R. Halabieh, Chem. Phys. Lett. 332 (2000) 331][1]. At low enough applied voltage, the band spacing increases with frequency. At higher voltages, the band spacing becomes independent of the field frequency. The effect of concentration of the inner electrolyte (Co2+), exactly opposes that observed under DC electric field; i.e., the band spacing decreases with increasing concentration. The dynamics were shown to be governed by a competitive scenario between the diffusion gradient and the alternating current electric field factor.

  9. Relationship of the interplanetary electric field to the high-latitude ionospheric electric field and currents Observations and model simulation

    NASA Technical Reports Server (NTRS)

    Clauer, C. R.; Banks, P. M.

    1986-01-01

    The electrical coupling between the solar wind, magnetosphere, and ionosphere is studied. The coupling is analyzed using observations of high-latitude ion convection measured by the Sondre Stromfjord radar in Greenland and a computer simulation. The computer simulation calculates the ionospheric electric potential distribution for a given configuration of field-aligned currents and conductivity distribution. The technique for measuring F-region in velocities at high time resolution over a large range of latitudes is described. Variations in the currents on ionospheric plasma convection are examined using a model of field-aligned currents linking the solar wind with the dayside, high-latitude ionosphere. The data reveal that high-latitude ionospheric convection patterns, electric fields, and field-aligned currents are dependent on IMF orientation; it is observed that the electric field, which drives the F-region plasma curve, responds within about 14 minutes to IMF variations in the magnetopause. Comparisons of the simulated plasma convection with the ion velocity measurements reveal good correlation between the data.

  10. New Effects of the Interaction of Electric and Gravitational Fields

    NASA Astrophysics Data System (ADS)

    Krechet, V. G.; Oshurko, V. B.; Ivanova, S. D.

    2018-06-01

    The properties of stationary distributions of self-gravitating electric fields are considered within the framework of GRT with the presence of a vortex component in the gravitational field taken into account. It is shown that under the indicated conditions, cylindrically symmetric configurations of the gravitational field and electric fields can lead to the formation of "wormholes" and other remarkable effects.

  11. The effect of longitudinal conductance variations on the ionospheric prompt penetration electric fields

    NASA Astrophysics Data System (ADS)

    Sazykin, S.; Wolf, R.; Spiro, R.; Fejer, B.

    Ionospheric prompt penetration electric fields of magnetospheric origin, together with the atmospheric disturbance dynamo, represent the most important parameters controlling the storm-time dynamics of the low and mid-latitude ionosphere. These prompt penetration fields result from the disruption of region-2 field-aligned shielding currents during geomagnetically disturbed conditions. Penetration electric fields con- trol, to a large extent, the generation and development of equatorial spread-F plasma instabilities as well as other dynamic space weather phenomena in the ionosphere equatorward of the auroral zone. While modeling studies typically agree with average patterns of prompt penetration fields, experimental results suggest that longitudinal variations of the ionospheric con- ductivities play a non-negligible role in controlling spread-F phenomena, an effect that has not previously been modeled. We present first results of modeling prompt pene- tration electric fields using a version of the Rice Convection Model (RCM) that allows for longitudinal variations in the ionospheric conductance tensor. The RCM is a first- principles numerical ionosphere-magnetosphere coupling model that solves for the electric fields, field-aligned currents, and particle distributions in the ionosphere and inner/middle magnetosphere. We compare these new theoretical results with electric field observations.

  12. Effects of a parallel electric field and the geomagnetic field in the topside ionosphere on auroral and photoelectron energy distributions

    NASA Technical Reports Server (NTRS)

    Min, Q.-L.; Lummerzheim, D.; Rees, M. H.; Stamnes, K.

    1993-01-01

    The consequences of electric field acceleration and an inhomogeneous magnetic field on auroral electron energy distributions in the topside ionosphere are investigated. The one-dimensional, steady state electron transport equation includes elastic and inelastic collisions, an inhomogeneous magnetic field, and a field-aligned electric field. The case of a self-consistent polarization electric field is considered first. The self-consistent field is derived by solving the continuity equation for all ions of importance, including diffusion of O(+) and H(+), and the electron and ion energy equations to derive the electron and ion temperatures. The system of coupled electron transport, continuity, and energy equations is solved numerically. Recognizing observations of parallel electric fields of larger magnitude than the baseline case of the polarization field, the effect of two model fields on the electron distribution function is investigated. In one case the field is increased from the polarization field magnitude at 300 km to a maximum at the upper boundary of 800 km, and in another case a uniform field is added to the polarization field. Substantial perturbations of the low energy portion of the electron flux are produced: an upward directed electric field accelerates the downward directed flux of low-energy secondary electrons and decelerates the upward directed component. Above about 400 km the inhomogeneous magnetic field produces anisotropies in the angular distribution of the electron flux. The effects of the perturbed energy distributions on auroral spectral emission features are noted.

  13. Effects of a Parallel Electric Field and the Geomagnetic Field in the Topside Ionosphere on Auroral and Photoelectron Energy Distributions

    NASA Technical Reports Server (NTRS)

    Min, Q.-L.; Lummerzheim, D.; Rees, M. H.; Stamnes, K.

    1993-01-01

    The consequences of electric field acceleration and an inhomogencous magnetic field on auroral electron energy distributions in the topside ionosphere are investigated. The one- dimensional, steady state electron transport equation includes elastic and inelastic collisions, an inhomogencous magnetic field, and a field-aligned electric field. The case of a self-consistent polarization electric field is considered first. The self-consistent field is derived by solving the continuity equation for all ions of importance, including diffusion of 0(+) and H(+), and the electron and ion energy equations to derive the electron and ion temperatures. The system of coupled electron transport, continuity, and energy equations is solved numerically. Recognizing observations of parallel electric fields of larger magnitude than the baseline case of the polarization field, the effect of two model fields on the electron distribution function in investigated. In one case the field is increased from the polarization field magnitude at 300 km to a maximum at the upper boundary of 800 km, and in another case a uniform field is added to the polarization field. Substantial perturbations of the low energy portion of the electron flux are produced: an upward directed electric field accelerates the downward directed flux of low-energy secondary electrons and decelerates the upward directed component. Above about 400 km the inhomogencous magnetic field produces anisotropies in the angular distribution of the electron flux. The effects of the perturbed energy distributions on auroral spectral emission features are noted.

  14. A New Electric Field in Asymmetric Magnetic Reconnection

    NASA Astrophysics Data System (ADS)

    Malakit, K.; Shay, M. A.; Cassak, P.; Ruffolo, D. J.

    2013-12-01

    Magnetic reconnection is an important plasma process that drives the dynamics of the plasma in the magnetosphere and plays a crucial role in the interaction between magnetospheric and magnetosheath plasma. It has been shown that when a reconnection occurs in a collisionless plasma, it exhibits the Hall electric field, an in-plane electric field structure pointing toward the X-line. In this work, we show that when the reconnection has asymmetric inflow conditions such as the reconnection at the day-side magnetopause, a new in-plane electric field structure can exist. This electric field points away from the X-line and is distinct from the known Hall electric field. We argue that the origin of the electric field is associated with the physics of finite Larmor radius. A theory and predictions of the electric field properties are presented and backed up by results from fully kinetic particle-in-cell simulations of asymmetric reconnection with various inflow conditions. Under normal day-side reconnection inflow conditions, the electric field is expected to occur on the magnetospheric side of the X-line pointing Earthward. Hence, it has a potential to be used as a signature for satellites, such as the upcoming Magnetospheric Multi-Scale (MMS) mission, to locate the reconnection sites at the day-side magnetopause. This research was supported by the postdoctoral research sponsorship of Mahidol University (KM), NSF grants ATM-0645271 - Career Award (MAS) and AGS-0953463 (PAC), NASA grants NNX08A083G - MMS IDS, NNX11AD69G, and NNX13AD72G (MAS) and NNX10AN08A (PAC), and the Thailand Research Fund (DR).

  15. Effects Of Electric Field On Hydrocarbon-Fueled Flames

    NASA Technical Reports Server (NTRS)

    Yuan, Z.-G.; Hegde, U.

    2003-01-01

    It has been observed that flames are susceptible to electric fields that are much weaker than the breakdown field strength of the flame gases. When an external electric field is imposed on a flame, the ions generated in the flame reaction zone drift in the direction of the electric forces exerted on them. The moving ions collide with the neutral species and change the velocity distribution in the affected region. This is often referred to as ionic wind effect. In addition, the removal of ions from the flame reaction zone can alter the chemical reaction pathway of the flame. On the other hand, the presence of space charges carried by moving ions affects the electric field distribution. As a result, the flame often changes its shape, location and color once an external electric field is applied. The interplay between the flame movement and the change of electric field makes it difficult to determine the flame location for a given configuration of electrodes and fuel source. In normal gravity, the buoyancy-induced flow often complicates the problem and hinders detailed study of the interaction between the flame and the electric field. In this work, the microgravity environment established at the 2.2 Second Drop Tower at the NASA Glenn Research Center is utilized to effectively remove the buoyant acceleration. The interaction between the flame and the electric field is studied in a one-dimensional domain. A specially designed electrode makes flame current measurements possible; thus, the mobility of ions, ion density, and ionic wind effect can be evaluated.

  16. Application of low-frequency alternating current electric fields via interdigitated electrodes: effects on cellular viability, cytoplasmic calcium, and osteogenic differentiation of human adipose-derived stem cells.

    PubMed

    McCullen, Seth D; McQuilling, John P; Grossfeld, Robert M; Lubischer, Jane L; Clarke, Laura I; Loboa, Elizabeth G

    2010-12-01

    Electric stimulation is known to initiate signaling pathways and provides a technique to enhance osteogenic differentiation of stem and/or progenitor cells. There are a variety of in vitro stimulation devices to apply electric fields to such cells. Herein, we describe and highlight the use of interdigitated electrodes to characterize signaling pathways and the effect of electric fields on the proliferation and osteogenic differentiation of human adipose-derived stem cells (hASCs). The advantage of the interdigitated electrode configuration is that cells can be easily imaged during short-term (acute) stimulation, and this identical configuration can be utilized for long-term (chronic) studies. Acute exposure of hASCs to alternating current (AC) sinusoidal electric fields of 1 Hz induced a dose-dependent increase in cytoplasmic calcium in response to electric field magnitude, as observed by fluorescence microscopy. hASCs that were chronically exposed to AC electric field treatment of 1 V/cm (4 h/day for 14 days, cultured in the osteogenic differentiation medium containing dexamethasone, ascorbic acid, and β-glycerol phosphate) displayed a significant increase in mineral deposition relative to unstimulated controls. This is the first study to evaluate the effects of sinusoidal AC electric fields on hASCs and to demonstrate that acute and chronic electric field exposure can significantly increase intracellular calcium signaling and the deposition of accreted calcium under osteogenic stimulation, respectively.

  17. Nitrergic signalling via interstitial cells of Cajal regulates motor activity in murine colon.

    PubMed

    Lies, Barbara; Beck, Katharina; Keppler, Jonas; Saur, Dieter; Groneberg, Dieter; Friebe, Andreas

    2015-10-15

    In the enteric nervous systems, NO is released from nitrergic neurons as a major inhibitory neurotransmitter. NO acts via NO-sensitive guanylyl cyclase (NO-GC), which is found in different gastrointestinal (GI) cell types including smooth muscle cells (SMCs) and interstitial cells of Cajal (ICC). The precise mechanism of nitrergic signalling through these two cell types to regulate colonic spontaneous contractions is not fully understood yet. In the present study we investigated the impact of endogenous and exogenous NO on colonic contractile motor activity using mice lacking nitric oxide-sensitive guanylyl cyclase (NO-GC) globally and specifically in SMCs and ICC. Longitudinal smooth muscle of proximal colon from wild-type (WT) and knockout (KO) mouse strains exhibited spontaneous contractile activity ex vivo. WT and smooth muscle-specific guanylyl cyclase knockout (SMC-GCKO) colon showed an arrhythmic contractile activity with varying amplitudes and frequencies. In contrast, colon from global and ICC-specific guanylyl cyclase knockout (ICC-GCKO) animals showed a regular contractile rhythm with constant duration and amplitude of the rhythmic contractions. Nerve blockade (tetrodotoxin) or specific blockade of NO signalling (L-NAME, ODQ) did not significantly affect contractions of GCKO and ICC-GCKO colon whereas the arrhythmic contractile patterns of WT and SMC-GCKO colon were transformed into uniform motor patterns. In contrast, the response to electric field-stimulated neuronal NO release was similar in SMC-GCKO and global GCKO. In conclusion, our results indicate that basal enteric NO release acts via myenteric ICC to influence the generation of spontaneous contractions whereas the effects of elevated endogenous NO are mediated by SMCs in the murine proximal colon. © 2015 The Authors. The Journal of Physiology © 2015 The Physiological Society.

  18. Role for NK(1) and NK(2) receptors in the motor activity in mouse colon.

    PubMed

    Mulè, Flavia; Amato, Antonella; Serio, Rosa

    2007-09-10

    The present study examined the effects induced by endogenous and exogenous activation of NK(1) and NK(2) receptors on the mechanical activity of mouse proximal colon. Experiments were performed in vitro recording the changes in intraluminal pressure from isolated colonic segments. Electrical field stimulation in the presence of atropine and guanethidine produced a small relaxation, followed by nonadrenergic noncholinergic (NANC) contraction. SR140333, NK(1) receptor antagonist, or SR48968, NK(2) receptor antagonist, significantly reduced the contraction, although SR48968 appeared more efficacious. The co-administration of SR140333 and SR48968 virtually abolished the NANC contraction. [Sar(9), Met(O(2))(11)]-substance P, selective NK(1) receptor agonist, induced a concentration-dependent biphasic effect, contraction followed by reduction of the mechanical spontaneous activity. Both effects were antagonized by SR140333, but not by SR48968. [beta-Ala(8)]-neurokinin A (4-10), selective NK(2) receptor agonist, evoked concentration-dependent contraction, which was antagonized by SR48968, but not by SR140333. The contraction induced by [Sar(9), Met(O(2))(11)]-substance P, but not by [beta-Ala(8)]-neurokinin A (4-10), was reduced by tetrodotoxin or atropine, and increased by N(omega)-nitro-L-arginine methyl ester (L-NAME), inhibitor of nitric oxide synthase. The inhibitory effects induced by [Sar(9), Met(O(2))(11)]-substance P were abolished by tetrodotoxin or L-NAME. The results of the present study suggest that in mouse colon both NK(1) and NK(2) receptors are junctionally activated by endogenous tachykinins to cause an additive response. NK(1) receptors appear to be located on cholinergic and on nitrergic neurons as well as on smooth muscle cells, whereas NK(2) receptors seem to be present exclusively on smooth muscle cells.

  19. Robust modulation of arousal regulation, performance, and frontostriatal activity through central thalamic deep brain stimulation in healthy nonhuman primates

    PubMed Central

    Ryou, Jae-Wook; Wei, Xuefeng F.; Butson, Christopher R.; Schiff, Nicholas D.; Purpura, Keith P.

    2016-01-01

    The central thalamus (CT) is a key component of the brain-wide network underlying arousal regulation and sensory-motor integration during wakefulness in the mammalian brain. Dysfunction of the CT, typically a result of severe brain injury (SBI), leads to long-lasting impairments in arousal regulation and subsequent deficits in cognition. Central thalamic deep brain stimulation (CT-DBS) is proposed as a therapy to reestablish and maintain arousal regulation to improve cognition in select SBI patients. However, a mechanistic understanding of CT-DBS and an optimal method of implementing this promising therapy are unknown. Here we demonstrate in two healthy nonhuman primates (NHPs), Macaca mulatta, that location-specific CT-DBS improves performance in visuomotor tasks and is associated with physiological effects consistent with enhancement of endogenous arousal. Specifically, CT-DBS within the lateral wing of the central lateral nucleus and the surrounding medial dorsal thalamic tegmental tract (DTTm) produces a rapid and robust modulation of performance and arousal, as measured by neuronal activity in the frontal cortex and striatum. Notably, the most robust and reliable behavioral and physiological responses resulted when we implemented a novel method of CT-DBS that orients and shapes the electric field within the DTTm using spatially separated DBS leads. Collectively, our results demonstrate that selective activation within the DTTm of the CT robustly regulates endogenous arousal and enhances cognitive performance in the intact NHP; these findings provide insights into the mechanism of CT-DBS and further support the development of CT-DBS as a therapy for reestablishing arousal regulation to support cognition in SBI patients. PMID:27582298

  20. Electric fields measured by ISEE-1 within and near the neutral sheet during quiet and active times

    NASA Technical Reports Server (NTRS)

    Cattell, C. A.; Mozer, F. S.

    1982-01-01

    An understanding of the physical processes occurring in the magnetotail and plasmasheet during different interplanetary magnetic field orientations and differing levels of ground magnetic activity is crucial for the development of a theory of energy transfer from the solar wind to the particles which produce auroral arcs. In the present investigation, the first observations of electric fields during neutral sheet crossings are presented, taking into account the statistical correlations of the interplanetary magnetic field direction and ground activity with the character of the electric field. The electric field data used in the study were obtained from a double probe experiment on the ISEE-1 satellite. The observations suggest that turbulent electric and magnetic fields are intimately related to plasma acceleration in the neutral sheet and to the processes which create auroral particles.

  1. Interpretation of the electric fields measured in an ionospheric critical ionization velocity experiment

    NASA Technical Reports Server (NTRS)

    Brenning, N.; Faelthammar, C.-G.; Marklund, G.; Haerendel, G.; Kelley, M. C.; Pfaff, R.

    1991-01-01

    The quasi-dc electric fields measured in the CRIT I ionospheric release experiment are studied. In the experiment, two identical barium shaped charges were fired toward a main payload, and three-dimensional measurements of the electric field inside the streams were made. The relevance of proposed mechanisms for electron heating in the critical ionization velocity (CIV) mechanism is addressed. It is concluded that both the 'homogeneous' and the 'ionizing front' models probably are valid, but in different parts of the streams. It is also possible that electrons are directly accelerated by a magnetic field-aligned component of the electric field. The coupling between the ambient ionosphere and the ionized barium stream is more complicated that is usually assumed in CIV theories, with strong magnetic-field-aligned electric fields and probably current limitation as important processes.

  2. Piezoelectric and optical setup to measure an electrical field: application to the longitudinal near-field generated by a tapered coax.

    PubMed

    Euphrasie, S; Vairac, P; Cretin, B; Lengaigne, G

    2008-03-01

    We propose a new setup to measure an electrical field in one direction. This setup is made of a piezoelectric sintered lead zinconate titanate film and an optical interferometric probe. We used this setup to investigate how the shape of the extremity of a coaxial cable influences the longitudinal electrical near-field generated by it. For this application, we designed our setup to have a spatial resolution of 100 microm in the direction of the electrical field. Simulations and experiments are presented.

  3. Effect of electric field on RbCl quantum pseudodot qubit

    NASA Astrophysics Data System (ADS)

    Liang, Zhi-Hui; Xiao, Jing-Lin

    2018-04-01

    By employing the variational method of Pekar type, we study the effects of electric field on RbCl quantum pseudodot (QPD) qubits. Our results confirm that (1) the electron oscillates in the RbCl QPD with a certain period; (2) the electron's probability density is a raising function of electric field; (3) the oscillating frequency is an increasing one of the electric field and the two-dimensional electron gas chemical potential. Two ways are found for prolonging the lifetime of the qubit and suppressing the decoherence in the quantum information field.

  4. A rocket borne instrument to measure electric fields inside electrified clouds

    NASA Technical Reports Server (NTRS)

    Ruhnke, L. H.

    1971-01-01

    The development of a rocket borne instrument to measure electric fields in thunderstorms is described. Corona currents from a sharp needle atop a small rocket are used to sense the electric field. A high ohm resistor in series with the corona needle linearizes the relationship between corona current and electric field. The corona current feeds a relaxation oscillator, whose pulses trigger a transmitter which operates in the 395 to 410 MHz meteorological band. The instrument senses fields between 5 kV/m and 100 kV/m.

  5. Effectiveness of a worker-worn electric-field sensor to detect power-line proximity and electrical-contact.

    PubMed

    Zeng, Shengke; Powers, John R; Newbraugh, Bradley H

    2010-06-01

    Construction workers suffer the most electrocutions among all industries. Currently, there are no electrical contact warning devices on the market to protect workers. This paper proposes a worker-worn electric-field sensor. As the worker is in proximity to, or in contact with, a live power-circuit, the sensor sets off an audible/visual warning alarm. The sensor also has the potential to wirelessly trip a wireless-capable circuit breaker, and to trigger a wireless transmitter to notify emergency response of an electrical contact. An experiment was conducted to measure electric-field variation on simulated human-wrists (10 defrosted hog-legs) in various proximities and in electrical-contact to a simulated power-circuit. The purpose of these tests was to determine the feasibility of developing a worker-worn electric-field detection sensor for use in protecting workers from contact with energized electrical conductors. This study observed a significant electric-field-magnitude increase as a hog-leg approaches the live-circuit, and the distinct electric-field-magnitude jump as the leg contacts with the live-circuit. The observation indicates that this sensor can be an effective device to warn the workers of electrical hazards. Additionally, the sensor has the potential to wirelessly trip a wireless-capable circuit-breaker and trigger a wireless transmitter (such as a cell phone) to notify an emergency response. The prompt notification prevents the worker from further injury caused by postponed medical-care. Widespread use of this sensor could lower electrocution and electrically related injury rates in the construction industry. (c) 2010 Elsevier Ltd. All rights reserved.

  6. Engineering of electric field distribution in GaN(cap)/AlGaN/GaN heterostructures: theoretical and experimental studies

    NASA Astrophysics Data System (ADS)

    Gladysiewicz, M.; Janicki, L.; Misiewicz, J.; Sobanska, M.; Klosek, K.; Zytkiewicz, Z. R.; Kudrawiec, R.

    2016-09-01

    Polarization engineering of GaN-based heterostructures opens a way to develop advanced transistor heterostructures, although measurement of the electric field in such heterostructures is not a simple task. In this work, contactless electroreflectance (CER) spectroscopy has been applied to measure the electric field in GaN-based heterostructures. For a set of GaN(d  =  0, 5, 15, and 30 nm)/AlGaN(20 nm)/GaN(buffer) heterostructures a decrease of electric field in the GaN(cap) layer from 0.66 MV cm-1 to 0.27 MV cm-1 and an increase of the electric field in the AlGaN layer from 0.57 MV cm-1 to 0.99 MV cm-1 have been observed with the increase in the GaN(cap) thickness from 5-30 nm. For a set of GaN(20 nm)/AlGaN(d  =  10, 20, 30, and 40 nm)/GaN(buffer) heterostructures a decrease of the electric field in the AlGaN layer from 1.77 MV cm-1 to 0.64 MV cm-1 and an increase of the electric field in the GaN layer from 0.57 MV cm-1 to 0.99 MV cm-1 were observed with the increase in the AlGaN thickness from 10-40 nm. To determine the distribution of the electric field in these heterostructures the Schrödinger and Poisson equations are solved in a self-consistent manner and matched with experimental data. It is shown that the built-in electric field in the GaN(cap) and AlGaN layers obtained from measurements does not reach values of electric field resulting only from polarization effects. The measured electric fields are smaller due to a screening of polarization effects by free carriers, which are inhomogeneously distributed across the heterostructure and accumulate at interfaces. The results clearly demonstrate that CER measurements supported by theoretical calculations are able to determine the electric field distribution in GaN-based heterostructures quantitatively, which is very important for polarization engineering in this material system.

  7. Dielectric-spectroscopy approach to ferrofluid nanoparticle clustering induced by an external electric field.

    PubMed

    Rajnak, Michal; Kurimsky, Juraj; Dolnik, Bystrik; Kopcansky, Peter; Tomasovicova, Natalia; Taculescu-Moaca, Elena Alina; Timko, Milan

    2014-09-01

    An experimental study of magnetic colloidal particles cluster formation induced by an external electric field in a ferrofluid based on transformer oil is presented. Using frequency domain isothermal dielectric spectroscopy, we study the influence of a test cell electrode separation distance on a low-frequency relaxation process. We consider the relaxation process to be associated with an electric double layer polarization taking place on the particle surface. It has been found that the relaxation maximum considerably shifts towards lower frequencies when conducting the measurements in the test cells with greater electrode separation distances. As the electric field intensity was always kept at a constant value, we propose that the particle cluster formation induced by the external ac electric field accounts for that phenomenon. The increase in the relaxation time is in accordance with the Schwarz theory of electric double layer polarization. In addition, we analyze the influence of a static electric field generated by dc bias voltage on a similar shift in the relaxation maximum position. The variation of the dc electric field for the hysteresis measurements purpose provides understanding of the development of the particle clusters and their decay. Following our results, we emphasize the utility of dielectric spectroscopy as a simple, complementary method for detection and study of clusters of colloidal particles induced by external electric field.

  8. Fabrication and electrorotation of a novel epoxy based micromotor working in a uniform DC electric field

    NASA Astrophysics Data System (ADS)

    Bauer, Rita A.; Kelemen, Lóránd; Nakano, Masami; Totsuka, Atsushi; Zrínyi, Miklós

    2015-10-01

    We have presented the first direct observation of electric field induced rotation of epoxy based polymer rotors. Polymer disks, hollow cylinders and gears were prepared in few micrometer dimensions as rotors. Electrorotation of these sub-millimeter sized tools was studied under uniform dc electric field. The effects of shape, size and thickness were investigated. The novel epoxy based micro devices show intensive spinning in a uniform dc electric field. The rotational speed of micron-sized polymer rotors can be conveniently tuned in a wide range (between 300 and 3000 rpm) by the electric field intensity, opening new perspectives for their use in several MEMS applications.

  9. Measuring of the pitch variation of cholesteric liquid crystals under electric field using wavelength-swept laser

    NASA Astrophysics Data System (ADS)

    Ko, Myeong Ock; Kim, Sung-Jo; Kim, Jong-Hyun; Jeon, Min Yong

    2017-04-01

    We measure the pitch variation of cholesteric liquid crystals (CLCs) according to the applied electric field using a wavelength-swept laser. While the electric field is applied to the CLC, the pitch of the CLC is elongated normal to the direction of electric field. Therefore, the reflection band is shifted to the longer wavelength. When the applied electric field to the CLC cell was over 1.52 V/μm, the reflection band was changed to the longer wavelength of about 75.1 nm. We believe that the dynamic behavior of the CLC can be analyzed if a high-speed wavelength-swept laser is used as an optical source.

  10. Electronic structure and its external electric field modulation of PbPdO2 ultrathin slabs with (002) and (211) preferred orientations.

    PubMed

    Yang, Yanmin; Zhong, Kehua; Xu, Guigui; Zhang, Jian-Min; Huang, Zhigao

    2017-07-31

    The Electronic structure of PbPdO 2 with (002) and (211) preferred orientations were investigated using first-principles calculation. The calculated results indicate that, (002) and (211) orientations exhibit different electric field dependence of band-gap and carrier concentration. The small band gap and more sensitive electric field modulation of band gap were found in (002) orientation. Moreover, the electric field modulation of the resistivity up to 3-4 orders of magnitude is also observed in (002) slab, which reveals that origin of colossal electroresistance. Lastly, electric field modulation of band gap is well explained. This work should be significant for repeating the colossal electroresistance.

  11. Electric field-induced ferromagnetic resonance in a CoFeB/MgO magnetic tunnel junction under dc bias voltages

    NASA Astrophysics Data System (ADS)

    Kanai, Shun; Gajek, Martin; Worledge, D. C.; Matsukura, Fumihiro; Ohno, Hideo

    2014-12-01

    We measure homodyne-detected ferromagnetic resonance (FMR) induced by the electric-field effect in a CoFeB/MgO/CoFeB magnetic tunnel junction (MTJ) with perpendicular magnetic easy axis under dc bias voltages up to 0.1 V. From the bias dependence of the resonant frequency, we find that the first order perpendicular magnetic anisotropy is modulated by the applied electric field, whereas the second order component is virtually independent of the electric field. The lineshapes of the FMR spectra are bias dependent, which are explained by the combination of electric-field effect and reflection of the bias voltage from the MTJ.

  12. Stripe formation in an immiscible polymer blend under electric and shear-flow fields

    NASA Astrophysics Data System (ADS)

    Na, Yang-Ho; Shibuya, Tetsunori; Ujiie, Seiji; Nagaya, Tomoyuki; Orihara, Hiroshi

    2008-04-01

    We found a stripe formation in an emulsion of a liquid crystalline polymer (LCP) and a machine oil (OIL) in electric and shear fields. Through the simultaneous measurement with a confocal scanning laser microscope and a rheometer, it was clearly shown that the formation of stripes, which are periodically arrayed, leads to the increase of the shear stress. The droplets, which are one component of the emulsion, start to be connected at low electric fields and then change into the stripes with the increase of electric field. Finally, a three-dimensional network is formed at high electric fields. The period and fluctuation of the stripe structure were also investigated in detail.

  13. Enhanced Fair-Weather Electric Fields Soon After Sunrise

    NASA Technical Reports Server (NTRS)

    Marshall, T. C.; Rust, W. D.; Stolzenburg, M.; Roeder, W.; Krehbiel, P. R.

    1999-01-01

    The typical fair weather electric field at the ground is between -100 and -300 V/m. At the NASA Kennedy Space Center and US Air Force Cape Canaveral Air Station (KSC) the electric field at the ground sometimes reaches -400 to -1200 V/m within an hour or two after sunrise on days that otherwise seem to be fair weather. We refer to the enhanced negative electric fields as the "sunrise enhancement." To investigate the sunrise enhancement at KSC we measured the electric field (E) in the first few hundred meters above the ground before and during several sunrise enhancements. From these E soundings we can infer the presence of charge layers and determine their thickness and charge density.

  14. Polymer-Polymer Bilayer Actuator

    NASA Technical Reports Server (NTRS)

    Su, Ji (Inventor); Harrison, Joycelyn S. (Inventor); St.Clair, Terry L. (Inventor)

    2003-01-01

    A device for providing an electromechanical response includes two polymeric webs bonded to each other along their lengths. At least one polymeric web is activated upon application thereto of an electric field and exhibits electrostriction by rotation of polar graft moieties within the polymeric web. In one embodiment, one of the two polymeric webs in an active web upon application thereto of the electric field, and the other polymeric web is a non-active web upon application thereto of the electric field. In another embodiment, both of the two polymeric webs are capable of being active webs upon application thereto of the electric field. However, these two polymeric webs are alternately activated and non-activated by the electric field.

  15. Large plasmaspheric electric fields at L approximately 2 measured by the S3-3 satellite during strong geomagnetic activity

    NASA Technical Reports Server (NTRS)

    Gonzalez, W. D.; Pinto, O., Jr.; Mendes, O., Jr.; Mozer, F. S.

    1986-01-01

    Large plasmaspheric electric fields at L is approximately 2 measured by the S3-3 satellite during strong geomagnetic activity are reported. Since these measurements have amplitudes comparable to those of the local corotation electric field, during such events the plasmasphere is expected to get strongly altered event at such low L-values. Furthermore, those measurements could contribute to the understanding of the physics of the convection/electric field penetration to the low latitude plasmaphere as well as the disturbed dynamo, during strong geomagnetic activity. For this purpose, critical parameters related to geomagnetic activity are also presented for the reported electric field events.

  16. Multipactor susceptibility on a dielectric with two carrier frequencies

    NASA Astrophysics Data System (ADS)

    Iqbal, Asif; Verboncoeur, John; Zhang, Peng

    2018-04-01

    This work investigates multipactor discharge on a single dielectric surface with two carrier frequencies of an rf electric field. We use Monte Carlo simulations and analytical calculations to obtain susceptibility diagrams in terms of the rf electric field and normal electric field due to the residual charge on the dielectric. It is found that in contrast to the single frequency case, in general, the presence of a second carrier frequency of the rf electric field increases the threshold of the magnitude of the rf electric field to initiate multipactor. The effects of the relative strength and phase, and the frequency separation of the two carrier frequencies are examined. The conditions to minimize mulitpactor are derived.

  17. Vector optical fields with polarization distributions similar to electric and magnetic field lines.

    PubMed

    Pan, Yue; Li, Si-Min; Mao, Lei; Kong, Ling-Jun; Li, Yongnan; Tu, Chenghou; Wang, Pei; Wang, Hui-Tian

    2013-07-01

    We present, design and generate a new kind of vector optical fields with linear polarization distributions modeling to electric and magnetic field lines. The geometric configurations of "electric charges" and "magnetic charges" can engineer the spatial structure and symmetry of polarizations of vector optical field, providing additional degrees of freedom assisting in controlling the field symmetry at the focus and allowing engineering of the field distribution at the focus to the specific applications.

  18. GROUNDWATER AND SOIL REMEDIATION USING ELECTRICAL FIELD

    EPA Science Inventory

    Enhancements of contaminants removal and degradation in low permeability soils by electrical fields are achieved by the processes of electrical heating, electrokinetics, and electrochemical reactions. Electrical heating increases soil temperature resulting in the increase of cont...

  19. Effects of coil orientation on the electric field induced by TMS over the hand motor area

    NASA Astrophysics Data System (ADS)

    Laakso, Ilkka; Hirata, Akimasa; Ugawa, Yoshikazu

    2014-01-01

    Responses elicited by transcranial magnetic stimulation (TMS) over the hand motor area depend on the position and orientation of the stimulating coil. In this work, we computationally investigate the induced electric field for multiple coil orientations and locations in order to determine which parts of the brain are affected and how the sensitivity of motor cortical activation depends on the direction of the electric field. The finite element method is used for calculating the electric field induced by TMS in two individual anatomical models of the head and brain. The orientation of the coil affects both the strength and depth of penetration of the electric field, and the field strongly depends on the direction of the sulcus, where the target neurons are located. The coil position that gives the strongest electric field in the target cortical region may deviate from the closest scalp location by a distance on the order of 1 cm. Together with previous experimental data, the results support the hypothesis that the cortex is most sensitive to fields oriented perpendicular to the cortical layers, while it is relatively insensitive to fields parallel to them. This has important implications for targeting of TMS. To determine the most effective coil position and orientation, it is essential to consider both biological (the direction of the targeted axons) and physical factors (the strength and direction of the electric field).

  20. Short perturbations of cosmic ray intensity and electric field in atmosphere

    NASA Technical Reports Server (NTRS)

    Alexeyenko, V. V.; Chudakov, A. E.; Sborshikov, V. G.; Tizengauzen, V. A.

    1985-01-01

    Short perturbations of cosmic ray intensity were found to be a common phenomenon. Its meteorological origin and correlation with electric field is established. The phenomenon can be explained by the electric field if the strength of this field at high altitudes is much bigger than the measured one at surface.

  1. An investigation into the induced electric fields from transcranial magnetic stimulation

    NASA Astrophysics Data System (ADS)

    Hadimani, Ravi; Lee, Erik; Duffy, Walter; Waris, Mohammed; Siddiqui, Waquar; Islam, Faisal; Rajamani, Mahesh; Nathan, Ryan; Jiles, David; David C Jiles Team; Walter Duffy Collaboration

    Transcranial magnetic stimulation (TMS) is a promising tool for noninvasive brain stimulation that has been approved by the FDA for the treatment of major depressive disorder. To stimulate the brain, TMS uses large, transient pulses of magnetic field to induce an electric field in the head. This transient magnetic field is large enough to cause the depolarization of cortical neurons and initiate a synaptic signal transmission. For this study, 50 unique head models were created from MRI images. Previous simulation studies have primarily used a single head model, and thus give a limited image of the induced electric field from TMS. This study uses finite element analysis simulations on 50 unique, heterogeneous head models to better investigate the relationship between TMS and the electric field induced in brain tissues. Results showed a significant variation in the strength of the induced electric field in the brain, which can be reasonably predicted by the distance from the TMS coil to the stimulated brain. Further, it was seen that some models had high electric field intensities in over five times as much brain volume as other models.

  2. A novel approach for in vitro studies applying electrical fields to cell cultures by transformer-like coupling.

    PubMed

    Hess, R; Neubert, H; Seifert, A; Bierbaum, S; Hart, D A; Scharnweber, D

    2012-12-01

    The purpose of this study was to develop a new apparatus for in vitro studies applying low frequency electrical fields to cells without interfering side effects like biochemical reactions or magnetic fields which occur in currently available systems. We developed a non-invasive method by means of the principle of transformer-like coupling where the magnetic field is concentrated in a toroid and, therefore, does not affect the cell culture. Next to an extensive characterization of the electrical field parameters, initial cell culture studies have focused on examining the response of bone marrow-derived human mesenchymal stem cells (MSCs) to pulsed electrical fields. While no significant differences in the proliferation of human MSCs could be detected, significant increases in ALP activity as well as in gene expression of other osteogenic markers were observed. The results indicate that transformer-like coupled electrical fields can be used to influence osteogenic differentiation of human MSCs in vitro and can pose a useful tool in understanding the influence of electrical fields on the cellular and molecular level.

  3. SwePep, a database designed for endogenous peptides and mass spectrometry.

    PubMed

    Fälth, Maria; Sköld, Karl; Norrman, Mathias; Svensson, Marcus; Fenyö, David; Andren, Per E

    2006-06-01

    A new database, SwePep, specifically designed for endogenous peptides, has been constructed to significantly speed up the identification process from complex tissue samples utilizing mass spectrometry. In the identification process the experimental peptide masses are compared with the peptide masses stored in the database both with and without possible post-translational modifications. This intermediate identification step is fast and singles out peptides that are potential endogenous peptides and can later be confirmed with tandem mass spectrometry data. Successful applications of this methodology are presented. The SwePep database is a relational database developed using MySql and Java. The database contains 4180 annotated endogenous peptides from different tissues originating from 394 different species as well as 50 novel peptides from brain tissue identified in our laboratory. Information about the peptides, including mass, isoelectric point, sequence, and precursor protein, is also stored in the database. This new approach holds great potential for removing the bottleneck that occurs during the identification process in the field of peptidomics. The SwePep database is available to the public.

  4. Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?

    PubMed

    Wang, Rui

    2002-11-01

    Bearing the public image of a deadly "gas of rotten eggs," hydrogen sulfide (H2S) can be generated in many types of mammalian cells. Functionally, H2S has been implicated in the induction of hippocampal long-term potentiation, brain development, and blood pressure regulation. By acting specifically on KATP channels, H2S can hyperpolarize cell membranes, relax smooth muscle cells, or decrease neuronal excitability. The endogenous metabolism and physiological functions of H2S position this gas well in the novel family of endogenous gaseous transmitters, termed "gasotransmitters." It is hypothesized that H2S is the third endogenous signaling gasotransmitter, besides nitric oxide and carbon monoxide. This positioning of H2S will open an exciting field-H2S physiology-encompassing realization of the interaction of H2S and other gasotransmitters, sulfurating modification of proteins, and the functional role of H2S in multiple systems. It may shed light on the pathogenesis of many diseases related to the abnormal metabolism of H2S.

  5. Role of Endogenous Sulfur Dioxide in Regulating Vascular Structural Remodeling in Hypertension

    PubMed Central

    Chen, Selena; Tang, Chaoshu

    2016-01-01

    Sulfur dioxide (SO2), an emerging gasotransmitter, was discovered to be endogenously generated in the cardiovascular system. Recently, the physiological effects of endogenous SO2 were confirmed. Vascular structural remodeling (VSR), an important pathological change in many cardiovascular diseases, plays a crucial role in the pathogenesis of the diseases. Here, the authors reviewed the research progress of endogenous SO2 in regulating VSR by searching the relevant data from PubMed and Medline. In spontaneously hypertensive rats (SHRs) and pulmonary hypertensive rats, SO2/aspartate aminotransferase (AAT) pathway was significantly altered. SO2 inhibited vascular smooth muscle cell (VSMC) proliferation, promoted apoptosis, inhibited the synthesis of extracellular collagen but promoted its degradation, and enhanced antioxidative capacity, thereby playing a significant role in attenuating VSR. However, the detailed mechanisms needed to be further explored. Further studies in this field would be important for the better understanding of the pathogenesis of systemic hypertension and pulmonary hypertension. Also, clinical trials are needed to demonstrate if SO2 would be a potential therapeutic target in cardiovascular diseases. PMID:27721913

  6. Method of electric field flow fractionation wherein the polarity of the electric field is periodically reversed

    DOEpatents

    Stevens, Fred J.

    1992-01-01

    A novel method of electric field flow fractionation for separating solute molecules from a carrier solution is disclosed. The method of the invention utilizes an electric field that is periodically reversed in polarity, in a time-dependent, wave-like manner. The parameters of the waveform, including amplitude, frequency and wave shape may be varied to optimize separation of solute species. The waveform may further include discontinuities to enhance separation.

  7. Electric-Field-Induced Magnetization Reversal in a Ferromagnet-Multiferroic Heterostructure

    NASA Astrophysics Data System (ADS)

    Heron, J. T.; Trassin, M.; Ashraf, K.; Gajek, M.; He, Q.; Yang, S. Y.; Nikonov, D. E.; Chu, Y.-H.; Salahuddin, S.; Ramesh, R.

    2011-11-01

    A reversal of magnetization requiring only the application of an electric field can lead to low-power spintronic devices by eliminating conventional magnetic switching methods. Here we show a nonvolatile, room temperature magnetization reversal determined by an electric field in a ferromagnet-multiferroic system. The effect is reversible and mediated by an interfacial magnetic coupling dictated by the multiferroic. Such electric-field control of a magnetoelectric device demonstrates an avenue for next-generation, low-energy consumption spintronics.

  8. Electric-field-induced magnetization reversal in a ferromagnet-multiferroic heterostructure.

    PubMed

    Heron, J T; Trassin, M; Ashraf, K; Gajek, M; He, Q; Yang, S Y; Nikonov, D E; Chu, Y-H; Salahuddin, S; Ramesh, R

    2011-11-18

    A reversal of magnetization requiring only the application of an electric field can lead to low-power spintronic devices by eliminating conventional magnetic switching methods. Here we show a nonvolatile, room temperature magnetization reversal determined by an electric field in a ferromagnet-multiferroic system. The effect is reversible and mediated by an interfacial magnetic coupling dictated by the multiferroic. Such electric-field control of a magnetoelectric device demonstrates an avenue for next-generation, low-energy consumption spintronics.

  9. Nanoscale electron manipulation in metals with intense THz electric fields

    NASA Astrophysics Data System (ADS)

    Takeda, Jun; Yoshioka, Katsumasa; Minami, Yasuo; Katayama, Ikufumi

    2018-03-01

    Improved control over the electromagnetic properties of metals on a nanoscale is crucial for the development of next-generation nanoelectronics and plasmonic devices. Harnessing the terahertz (THz)-electric-field-induced nonlinearity for the motion of electrons is a promising method of manipulating the local electromagnetic properties of metals, while avoiding undesirable thermal effects and electronic transitions. In this review, we demonstrate the manipulation of electron delocalization in ultrathin gold (Au) films with nanostructures, by intense THz electric-field transients. On increasing the electric-field strength of the THz pulses, the transmittance in the THz-frequency region abruptly decreases around the percolation threshold. The observed THz-electric-field-induced nonlinearity is analysed, based on the Drude-Smith model. The results suggest that ultrafast electron delocalization occurs by electron tunnelling across the narrow insulating bridge between the Au nanostructures, without material breakdown. In order to quantitatively discuss the tunnelling process, we perform scanning tunnelling microscopy with carrier-envelope phase (CEP)-controlled single-cycle THz electric fields. By applying CEP-controlled THz electric fields to the 1 nm nanogap between a metal nanotip and graphite sample, many electrons could be coherently driven through the quantum tunnelling process, either from the nanotip to the sample or vice versa. The presented concept, namely, electron tunnelling mediated by CEP-controlled single-cycle THz electric fields, can facilitate the development of nanoscale electron manipulation, applicable to next-generation ultrafast nanoelectronics and plasmonic devices.

  10. Optical properties of an elliptic quantum ring: Eccentricity and electric field effects

    NASA Astrophysics Data System (ADS)

    Bejan, Doina; Stan, Cristina; Niculescu, Ecaterina C.

    2018-04-01

    We have theoretically studied the electronic and optical properties of a GaAs/AlGaAs elliptic quantum ring under in-plane electric field. The effects of an eccentric internal barrier -placed along the electric field direction, chosen as x-axis- and incident light polarization are particularly taken into account. The one-electron energy spectrum and wave functions are found using the adiabatic approximation and the finite element method within the effective-mass model. We show that it is possible to repair the structural distortion by applying an appropriate in-plane electric field, and the compensation is almost complete for all electronic states under study. For both concentric and eccentric quantum ring the intraband optical properties are very sensitive to the electric field and probe laser polarization. As expected, in the systems with eccentricity distortions the energy spectrum, as well as the optical response, strongly depends on the direction of the externally applied electric field, an effect that can be used as a signature of ring eccentricity. We demonstrated the possibility of generating second harmonic response at double resonance condition for incident light polarized along the x-axis if the electric field or/and eccentric barrier break the inversion symmetry. Also, strong third harmonic signal can be generated at triple resonance condition for a specific interval of electric field values when using y-polarized light.

  11. Fast electric control of the droplet size in a microfluidic T-junction droplet generator

    NASA Astrophysics Data System (ADS)

    Shojaeian, Mostafa; Hardt, Steffen

    2018-05-01

    The effect of DC electric fields on the generation of droplets of water and xanthan gum solutions in sunflower oil at a microfluidic T-junction is experimentally studied. The electric field leads to a significant reduction of the droplet diameter, by about a factor of 2 in the case of water droplets. The droplet size can be tuned by varying the electric field strength, an effect that can be employed to produce a stream of droplets with a tailor-made size sequence. Compared to the case of purely hydrodynamic droplet production without electric fields, the electric control has about the same effect on the droplet size if the electric stress at the liquid/liquid interface is the same as the hydrodynamic stress.

  12. Influence and Correction from the Human Body on the Measurement of a Power-Frequency Electric Field Sensor

    PubMed Central

    Xiao, Dongping; Liu, Huaitong; Zhou, Qiang; Xie, Yutong; Ma, Qichao

    2016-01-01

    According to the operating specifications of existing electric field measuring instruments, measuring technicians must be located far from the instruments to eliminate the influence of the human body occupancy on a spatial electric field. Nevertheless, in order to develop a portable safety protection instrument with an effective electric field warning function for working staff in a high-voltage environment, it is necessary to study the influence of an approaching human body on the measurement of an electric field and to correct the measurement results. A single-shaft electric field measuring instrument called the Type LP-2000, which was developed by our research team, is used as the research object in this study. First, we explain the principle of electric field measurement and describe the capacitance effect produced by the human body. Through a theoretical analysis, we show that the measured electric field value decreases as a human body approaches. Their relationship is linearly proportional. Then, the ratio is identified as a correction coefficient to correct for the influence of human body proximity. The conclusion drawn from the theoretical analysis is proved via simulation. The correction coefficient kb = 1.8010 is obtained on the basis of the linear fitting of simulated data. Finally, a physical experiment is performed. When no human is present, we compare the results from the Type LP-2000 measured with Narda EFA-300 and the simulated value to verify the accuracy of the Type LP-2000. For the case of an approaching human body, the correction coefficient kb* = 1.9094 is obtained by comparing the data measured with the Type LP-2000 to the simulated value. The correction coefficient obtained from the experiment (i.e., kb*) is highly consistent with that obtained from the simulation (i.e., kb). Two experimental programs are set; under these programs, the excitation voltages and distance measuring points are regulated to produce different electric field intensities. Using kb = 1.9094, the corrected measurement of electric field intensity can accurately reflect the original environmental electric field intensity, and the maximal error is less than 6% in all the data comparisons. These results verify the effectiveness of our proposed method. PMID:27294936

  13. Transmission of the electric fields to the low latitude ionosphere in the magnetosphere-ionosphere current circuit

    NASA Astrophysics Data System (ADS)

    Kikuchi, Takashi; Hashimoto, Kumiko K.

    2016-12-01

    The solar wind energy is transmitted to low latitude ionosphere in a current circuit from a dynamo in the magnetosphere to the equatorial ionosphere via the polar ionosphere. During the substorm growth phase and storm main phase, the dawn-to-dusk convection electric field is intensified by the southward interplanetary magnetic field (IMF), driving the ionospheric DP2 currents composed of two-cell Hall current vortices in high latitudes and Pedersen currents amplified at the dayside equator (EEJ). The EEJ-Region-1 field-aligned current (R1 FAC) circuit is completed via the Pedersen currents in midlatitude. On the other hand, the shielding electric field and the Region-2 FACs develop in the inner magnetosphere, tending to cancel the convection electric field at the mid-equatorial latitudes. The shielding often causes overshielding when the convection electric field reduces substantially and the EEJ is overcome by the counter electrojet (CEJ), leading to that even the quasi-periodic DP2 fluctuations are contributed by the overshielding as being composed of the EEJ and CEJ. The overshielding develop significantly during substorms and storms, leading to that the mid and low latitude ionosphere is under strong influence of the overshielding as well as the convection electric fields. The electric fields on the day- and night sides are in opposite direction to each other, but the electric fields in the evening are anomalously enhanced in the same direction as in the day. The evening anomaly is a unique feature of the electric potential distribution in the global ionosphere. DP2-type electric field and currents develop during the transient/short-term geomagnetic disturbances like the geomagnetic sudden commencements (SC), which appear simultaneously at high latitude and equator within the temporal resolution of 10 s. Using the SC, we can confirm that the electric potential and currents are transmitted near-instantaneously to low latitude ionosphere on both day- and night sides, which is explained by means of the light speed propagation of the TM0 mode waves in the Earth-ionosphere waveguide.

  14. Transmission of the Magnetospheric Electric Fields to the Low Latitude Ionosphere during Storm and Substorms

    NASA Astrophysics Data System (ADS)

    Kikuchi, T.; Hashimoto, K. K.; Ebihara, Y.; Tanaka, T.; Tomizawa, I.; Nagatsuma, T.

    2016-12-01

    The solar wind energy is transmitted to the low latitude ionosphere in a current circuit from a dynamo in the magnetosphere to the equatorial ionosphere via the polar ionosphere. During the substorm growth phase and storm main phase, the dawn-to-dusk convection electric field is intensified by the southward interplanetary magnetic field (IMF), driving the ionospheric DP2 currents composed of two-cell Hall current vortices in high latitudes and Pedersen currents amplified at the dayside equator (EEJ). The EEJ-Region-1 field-aligned current (R1 FAC) circuit is completed via the Pedersen currents in midlatitude. On the other hand, the shielding electric field and the Region-2 FACs develop in the inner magnetosphere, tending to cancel the convection electric field at the mid-equatorial latitudes. The shielding often causes overshielding when the convection electric field reduces substantially and the EEJ is overcome by the counter-electrojet (CEJ), leading to that even the quasi-periodic DP2 fluctuations are contributed by the overshielding. The overshielding develop significantly during substorms and storms, leading to that the mid and low latitude ionosphere is under strong influence of the overshielding as well as the convection electric fields. The electric fields on the day- and night-sides are in opposite direction to each other, but the electric fields in the evening are anomalously enhanced in the same direction as in the day. The evening anomaly is a unique feature of the electric potential distribution in the global ionosphere. DP2-type electric field and currents also develop during the transient/short-term geomagnetic disturbances like the geomagnetic sudden commencements (SC) and ULF pulsations, which appear simultaneously at high latitude and equator within the temporal resolution of 10 sec. Using the SC, we can confirm that the electric potential and currents are transmitted near-instantaneously to low latitude ionosphere on both the day- and night-sides, which is explained by means of the light speed propagation of the TM0 mode waves in the Earth-ionosphere waveguide.

  15. Influence and Correction from the Human Body on the Measurement of a Power-Frequency Electric Field Sensor.

    PubMed

    Xiao, Dongping; Liu, Huaitong; Zhou, Qiang; Xie, Yutong; Ma, Qichao

    2016-06-10

    According to the operating specifications of existing electric field measuring instruments, measuring technicians must be located far from the instruments to eliminate the influence of the human body occupancy on a spatial electric field. Nevertheless, in order to develop a portable safety protection instrument with an effective electric field warning function for working staff in a high-voltage environment, it is necessary to study the influence of an approaching human body on the measurement of an electric field and to correct the measurement results. A single-shaft electric field measuring instrument called the Type LP-2000, which was developed by our research team, is used as the research object in this study. First, we explain the principle of electric field measurement and describe the capacitance effect produced by the human body. Through a theoretical analysis, we show that the measured electric field value decreases as a human body approaches. Their relationship is linearly proportional. Then, the ratio is identified as a correction coefficient to correct for the influence of human body proximity. The conclusion drawn from the theoretical analysis is proved via simulation. The correction coefficient kb = 1.8010 is obtained on the basis of the linear fitting of simulated data. Finally, a physical experiment is performed. When no human is present, we compare the results from the Type LP-2000 measured with Narda EFA-300 and the simulated value to verify the accuracy of the Type LP-2000. For the case of an approaching human body, the correction coefficient kb* = 1.9094 is obtained by comparing the data measured with the Type LP-2000 to the simulated value. The correction coefficient obtained from the experiment (i.e., kb*) is highly consistent with that obtained from the simulation (i.e., kb). Two experimental programs are set; under these programs, the excitation voltages and distance measuring points are regulated to produce different electric field intensities. Using kb = 1.9094, the corrected measurement of electric field intensity can accurately reflect the original environmental electric field intensity, and the maximal error is less than 6% in all the data comparisons. These results verify the effectiveness of our proposed method.

  16. Disturbances of electrodynamic activity affect abortion in human

    NASA Astrophysics Data System (ADS)

    Jandová, A.; Nedbalová, M.; Kobilková, J.; Čoček, A.; Dohnalová, A.; Cifra, M.; Pokorný, J.

    2011-12-01

    Biochemical research of biological systems is highly developed, and it has disclosed a spectrum of chemical reactions, genetic processes, and the pathological development of various diseases. The fundamental hypothesis of physical processes in biological systems, in particular of coherent electrically polar vibrations and electromagnetic activity, was formulated by H. Fröhlich he assumed connection of cancer process with degradation of coherent electromagnetic activity. But the questions of cellular structures capable of the coherent electrical polar oscillation, mechanisms of energy supply, and the specific role of the endogenous electromagnetic fields in transport, organisation, interactions, and information transfer remained open. The nature of physical disturbances caused by some diseases (including the recurrent abortion in humans and the cancer) was unknown. We have studied the reasons of recurrent abortions in humans by means of the cell mediated immunity (using immunologic active RNA prepared from blood of inbred laboratory mice strain C3H/H2K, infected with the lactate dehydrogenase elevating virus-LD V) and the cytogenetic examination from karyotype pictures. The recurrent abortion group contained women with dg. spontaneous abortion (n = 24) and the control group was composed of 30 healthy pregnant women. Our hypothesis was related to quality of endometrium in relation to nidation of the blastocyst. The energetic insufficiency (ATP) inhibits normal development of fetus and placenta. We hope that these ideas might have impact on further research, which could provide background for effective interdisciplinary cooperation of malignant and non-malignant diseases.

  17. Inward transport of a toroidally confined plasma subject to strong radial electric fields

    NASA Technical Reports Server (NTRS)

    Roth, J. R.; Krawczonek, W. M.; Powers, E. J.; Hong, J.; Kim, Y.

    1977-01-01

    The paper aims at showing that the density and confinement time of a toroidal plasma can be enhanced by radial electric fields far stronger than the ambipolar values, and that, if such electric fields point into the plasma, radially inward transport can result. The investigation deals with low-frequency fluctuation-induced transport using digitally implemented spectral analysis techniques and with the role of strong applied radial electric fields and weak vertical magnetic fields on plasma density and particle confinement times in a Bumpy Torus geometry. Results indicate that application of sufficiently strong radially inward electric fields results in radially inward fluctuation-induced transport into the toroidal electrostatic potential well; this inward transport gives rise to higher average electron densities and longer particle confinement times in the toroidal plasma.

  18. Effects of electrical stimulation of ventral septal area on firing rates of pyrogen-treated thermosensitive neurons in preoptic anterior hypothalamus from rabbits.

    PubMed

    Dong, Jun; Xie, Xin-Hua; Lu, Da-Xiang; Fu, Yong-Mei

    2007-01-09

    Although there is considerable evidence supporting that fever evolved as a host defense response, it is important that the rise in body temperature would not be too high. Many endogenous cryogens or antipyretics that limit the rise in body temperature have been identified. Endogenous antipyretics attenuate fever by influencing the thermoregulatory neurons in the preoptic anterior hypothalamus (POAH) and in adjacent septal areas including ventral septal area (VSA). Our previous study showed that intracerebroventricular (I.C.V.) injection of interleukin-1beta (IL-1beta) affected electrophysiological activities of thermosensitive neurons in VSA regions, and electrical stimulation of POAH reversed the effect of IL-1beta. To further investigate the functional electrophysiological connection between POAH and VSA and its mechanisms in thermoregulation, the firing rates of thermosensitive neurons in POAH of forty-seven unit discharge were recorded by using extracellular microelectrode technique in New Zealand white rabbits. Our results show that the firing rates of the warm-sensitive neurons decreased significantly and those of the cold-sensitive neurons increased in POAH when the pyrogen (IL-1beta) was injected I.C.V. The effects of IL-1beta on firing rates in thermosensitive neurons of POAH were reversed by electrical stimulation of VSA. An arginine vasopressin (AVP) V1 antagonist abolished the regulatory effects of VSA on the firing rates in thermosensitive neurons of POAH evoked by IL-1beta. However, an AVP V2 antagonist had no effects. These data indicated that VSA regulates the activities of the thermosensitive neurons of POAH through AVP V1 but not AVP V2 receptor.

  19. Biosynthesis of acetyl-coenzyme A in the electric organ of Torpedo marmorata in relation to acetylcholine metabolism.

    PubMed Central

    Diebler, M F; Morot-Gaudry, Y

    1977-01-01

    Formation of acetyl-CoA through acetyl-CoA synthetase (forward reaction) and through choline acyltransferase (backward reaction) was investigated in tissue extract from the electric organ of Torpedo marmorata. When the tissue extract was submitted to gel filtration on Sephadex G-25, the formation of acetyl-CoA by acetyl-CoA synthetase appeared fully dependent on ATP and CoA and partially dependent on acetate (an endogenous supply of acetate is discussed). Choline acetyltransferase was a potent source of acetyl-CoA, only requiring acetylcholine and CoA, and was much more efficient than acetyl-CoA synthetase for concentrations of acetylcholine likely to be present in nerve endings. PMID:23101

  20. Electric field control of deterministic current-induced magnetization switching in a hybrid ferromagnetic/ferroelectric structure

    NASA Astrophysics Data System (ADS)

    Cai, Kaiming; Yang, Meiyin; Ju, Hailang; Wang, Sumei; Ji, Yang; Li, Baohe; Edmonds, Kevin William; Sheng, Yu; Zhang, Bao; Zhang, Nan; Liu, Shuai; Zheng, Houzhi; Wang, Kaiyou

    2017-07-01

    All-electrical and programmable manipulations of ferromagnetic bits are highly pursued for the aim of high integration and low energy consumption in modern information technology. Methods based on the spin-orbit torque switching in heavy metal/ferromagnet structures have been proposed with magnetic field, and are heading toward deterministic switching without external magnetic field. Here we demonstrate that an in-plane effective magnetic field can be induced by an electric field without breaking the symmetry of the structure of the thin film, and realize the deterministic magnetization switching in a hybrid ferromagnetic/ferroelectric structure with Pt/Co/Ni/Co/Pt layers on PMN-PT substrate. The effective magnetic field can be reversed by changing the direction of the applied electric field on the PMN-PT substrate, which fully replaces the controllability function of the external magnetic field. The electric field is found to generate an additional spin-orbit torque on the CoNiCo magnets, which is confirmed by macrospin calculations and micromagnetic simulations.

  1. Measurement of surface charges on the dielectric film based on field mills under the HVDC corona wire

    NASA Astrophysics Data System (ADS)

    Donglai, WANG; Tiebing, LU; Yuan, WANG; Bo, CHEN; Xuebao, LI

    2018-05-01

    The ion flow field on the ground is one of the significant parameters used to evaluate the electromagnetic environment of high voltage direct current (HVDC) power lines. HVDC lines may cross the greenhouses due to the restricted transmission corridors. Under the condition of ion flow field, the dielectric films on the greenhouses will be charged, and the electric fields in the greenhouses may exceed the limit value. Field mills are widely used to measure the ground-level direct current electric fields under the HVDC power lines. In this paper, the charge inversion method is applied to calculate the surface charges on the dielectric film according to the measured ground-level electric fields. The advantages of hiding the field mill probes in the ground are studied. The charge inversion algorithm is optimized in order to decrease the impact of measurement errors. Based on the experimental results, the surface charge distribution on a piece of quadrate dielectric film under a HVDC corona wire is studied. The enhanced effect of dielectric film on ground-level electric field is obviously weakened with the increase of film height. Compared with the total electric field strengths, the normal components of film-free electric fields at the corresponding film-placed positions have a higher effect on surface charge accumulation.

  2. The Relation between Reconnected Flux, the Parallel Electric Field, and the Reconnection Rate in a Three-Dimensional Kinetic Simulation of Magnetic Reconnection

    NASA Astrophysics Data System (ADS)

    Wendel, D. E.; Olson, D. K.; Hesse, M.; Karimabadi, H.; Daughton, W. S.

    2013-12-01

    We investigate the distribution of parallel electric fields and their relationship to the location and rate of magnetic reconnection of a large particle-in-cell simulation of 3D turbulent magnetic reconnection with open boundary conditions. The simulation's guide field geometry inhibits the formation of topological features such as separators and null points. Therefore, we derive the location of potential changes in magnetic connectivity by finding the field lines that experience a large relative change between their endpoints, i.e., the quasi-separatrix layer. We find a correspondence between the locus of changes in magnetic connectivity, or the quasi-separatrix layer, and the map of large gradients in the integrated parallel electric field (or quasi-potential). Furthermore, we compare the distribution of parallel electric fields along field lines with the reconnection rate. We find the reconnection rate is controlled by only the low-amplitude, zeroth and first-order trends in the parallel electric field, while the contribution from high amplitude parallel fluctuations, such as electron holes, is negligible. The results impact the determination of reconnection sites within models of 3D turbulent reconnection as well as the inference of reconnection rates from in situ spacecraft measurements. It is difficult through direct observation to isolate the locus of the reconnection parallel electric field amidst the large amplitude fluctuations. However, we demonstrate that a positive slope of the partial sum of the parallel electric field along the field line as a function of field line length indicates where reconnection is occurring along the field line.

  3. Piezostrain tuning exchange bias mediated by electric field in composite heterostructure

    NASA Astrophysics Data System (ADS)

    Li, Pingping; Zhou, Cai; Wang, Wenqiang; Cao, Cuimei; Yao, Jinli; Jiang, Changjun

    2017-12-01

    The change of unidirectional anisotropy and uniaxial anisotropy field turned by piezostrain in an IrMn/Co/Ta/Pb(Mg1/3Nb2/3)O3-PbTiO3 heterostructure with an exchange bias was investigated by ferromagnetic resonance at room temperature. The curve of the magnetic resonance field versus the electric fields showed an asymmetric butterfly-like behavior, which was consistent with the result of strain versus electric field curves. This butterfly-like behavior can be attributed to the piezostrain effect. Specifically, the non-volatile uniaxial anisotropy field and unidirectional anisotropy field behavior under different electric fields induced by piezostrain effect were obtained. Our result is crucial for further application of future multiferroic devices.

  4. ELECTRIC AND MAGNETIC FIELDS <100 KHZ IN ELECTRIC AND GASOLINE-POWERED VEHICLES.

    PubMed

    Tell, Richard A; Kavet, Robert

    2016-12-01

    Measurements were conducted to investigate electric and magnetic fields (EMFs) from 120 Hz to 10 kHz and 1.2 to 100 kHz in 9 electric or hybrid vehicles and 4 gasoline vehicles, all while being driven. The range of fields in the electric vehicles enclosed the range observed in the gasoline vehicles. Mean magnetic fields ranged from nominally 0.6 to 3.5 µT for electric/hybrids depending on the measurement band compared with nominally 0.4 to 0.6 µT for gasoline vehicles. Mean values of electric fields ranged from nominally 2 to 3 V m -1 for electric/hybrid vehicles depending on the band, compared with 0.9 to 3 V m -1 for gasoline vehicles. In all cases, the fields were well within published exposure limits for the general population. The measurements were performed with Narda model EHP-50C/EHP-50D EMF analysers that revealed the presence of spurious signals in the EHP-50C unit, which were resolved with the EHP-50D model. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  5. Mechanosensory hairs in bumblebees (Bombus terrestris) detect weak electric fields

    PubMed Central

    Sutton, Gregory P.; Clarke, Dominic; Morley, Erica L.; Robert, Daniel

    2016-01-01

    Bumblebees (Bombus terrestris) use information from surrounding electric fields to make foraging decisions. Electroreception in air, a nonconductive medium, is a recently discovered sensory capacity of insects, yet the sensory mechanisms remain elusive. Here, we investigate two putative electric field sensors: antennae and mechanosensory hairs. Examining their mechanical and neural response, we show that electric fields cause deflections in both antennae and hairs. Hairs respond with a greater median velocity, displacement, and angular displacement than antennae. Extracellular recordings from the antennae do not show any electrophysiological correlates to these mechanical deflections. In contrast, hair deflections in response to an electric field elicited neural activity. Mechanical deflections of both hairs and antennae increase with the electric charge carried by the bumblebee. From this evidence, we conclude that sensory hairs are a site of electroreception in the bumblebee. PMID:27247399

  6. Mechanosensory hairs in bumblebees (Bombus terrestris) detect weak electric fields.

    PubMed

    Sutton, Gregory P; Clarke, Dominic; Morley, Erica L; Robert, Daniel

    2016-06-28

    Bumblebees (Bombus terrestris) use information from surrounding electric fields to make foraging decisions. Electroreception in air, a nonconductive medium, is a recently discovered sensory capacity of insects, yet the sensory mechanisms remain elusive. Here, we investigate two putative electric field sensors: antennae and mechanosensory hairs. Examining their mechanical and neural response, we show that electric fields cause deflections in both antennae and hairs. Hairs respond with a greater median velocity, displacement, and angular displacement than antennae. Extracellular recordings from the antennae do not show any electrophysiological correlates to these mechanical deflections. In contrast, hair deflections in response to an electric field elicited neural activity. Mechanical deflections of both hairs and antennae increase with the electric charge carried by the bumblebee. From this evidence, we conclude that sensory hairs are a site of electroreception in the bumblebee.

  7. Electric Field Screening with Backflow at Pulsar Polar Cap

    NASA Astrophysics Data System (ADS)

    Kisaka, Shota; Asano, Katsuaki; Terasawa, Toshio

    2016-09-01

    Recent γ-ray observations suggest that particle acceleration occurs at the outer region of the pulsar magnetosphere. The magnetic field lines in the outer acceleration region (OAR) are connected to the neutron star surface (NSS). If copious electron-positron pairs are produced near the NSS, such pairs flow into the OAR and screen the electric field there. To activate the OAR, the electromagnetic cascade due to the electric field near the NSS should be suppressed. However, since a return current is expected along the field lines through the OAR, the outflow extracted from the NSS alone cannot screen the electric field just above the NSS. In this paper, we analytically and numerically study the electric field screening at the NSS, taking into account the effects of the backflowing particles from the OAR. In certain limited cases, the electric field is screened without significant pair cascade if only ultra-relativistic particles (γ \\gg 1) flow back to the NSS. On the other hand, if electron-positron pairs with a significant number density and mildly relativistic temperature, expected to distribute in a wide region of the magnetosphere, flow back to the NSS, these particles adjust the current and charge densities so that the electric field can be screened without pair cascade. We obtain the condition needed for the number density of particles to screen the electric field at the NSS. We also find that in the ion-extracted case from the NSS, bunches of particles are ejected to the outer region quasi-periodically, which is a possible mechanism of observed radio emission.

  8. Method of Mapping Anomalies in Homogenous Material

    NASA Technical Reports Server (NTRS)

    Taylor, Bryant D. (Inventor); Woodard, Stanley E. (Inventor)

    2016-01-01

    An electrical conductor and antenna are positioned in a fixed relationship to one another. Relative lateral movement is generated between the electrical conductor and a homogenous material while maintaining the electrical conductor at a fixed distance from the homogenous material. The antenna supplies a time-varying magnetic field that causes the electrical conductor to resonate and generate harmonic electric and magnetic field responses. Disruptions in at least one of the electric and magnetic field responses during this lateral movement are indicative of a lateral location of a subsurface anomaly. Next, relative out-of-plane movement is generated between the electrical conductor and the homogenous material in the vicinity of the anomaly's lateral location. Disruptions in at least one of the electric and magnetic field responses during this out-of-plane movement are indicative of a depth location of the subsurface anomaly. A recording of the disruptions provides a mapping of the anomaly.

  9. Estimation of the Lyman-α signal of the EFILE diagnostic under static or radiofrequency electric field in vacuum

    NASA Astrophysics Data System (ADS)

    Carlo, POGGI; Théo, GUILLAUME; Fabrice, DOVEIL; Laurence, CHÉRIGIER-KOVACIC

    2018-07-01

    The electric field induced Lyman-α emission diagnostic aims to provide a non intrusive and precise measurement of the electric field in plasma, using a beam of hydrogen atoms prepared in the metastable 2s state. The metastable particles are obtained by means of a proton beam extracted from a hydrogen plasma source, and neutralised by interaction with vaporised caesium. When a 2s atom enters a region where an electric field is present, it undergoes a transition to the 2p state (Stark mixing). It then quickly decays to the ground level, emitting Lyman-α radiation, which is collected by a photomultiplier. The 2s\\to 2p transition rate is proportional to the square of the magnitude of the electric field, and depends on the field oscillation frequency (with peaks around 1 GHz). By measuring the intensity of the Lyman-α radiation emitted by the beam it is possible to determine the magnitude of the field in a defined region. In this work, an analysis of the behaviour of the diagnostic under static or radiofrequency electric field is presented. Electric field simulations obtained with a finite element solver of Maxwell equations, combined with theoretical calculations of the Stark mixing transition rate, are used to develop a model for the interpretation of photomultiplier data. This method shows good agreement with experimental results for the static field case, and allows to measure the field magnitude for the oscillating case.

  10. Partial independence of bioelectric and biomagnetic fields and its implications for encephalography and cardiography

    NASA Astrophysics Data System (ADS)

    Irimia, Andrei; Swinney, Kenneth R.; Wikswo, John P.

    2009-05-01

    In this paper, we clearly demonstrate that the electric potential and the magnetic field can contain different information about current sources in three-dimensional conducting media. Expressions for the magnetic fields of electric dipole and quadrupole current sources immersed in an infinite conducting medium are derived, and it is shown that two different point dipole distributions that are electrically equivalent have different magnetic fields. Although measurements of the electric potential are not sufficient to determine uniquely the characteristics of a quadrupolar source, the radial component of the magnetic field can supply the additional information needed to resolve these ambiguities and to determine uniquely the configuration of dipoles required to specify the electric quadrupoles. We demonstrate how the process can be extended to even higher-order terms in an electrically silent series of magnetic multipoles. In the context of a spherical brain source model, it has been mathematically demonstrated that the part of the neuronal current generating the electric potential lives in the orthogonal complement of the part of the current generating the magnetic potential. This implies a mathematical relationship of complementarity between electroencephalography and magnetoencephalography, although the theoretical result in question does not apply to the nonspherical case [G. Dassios, Math. Med. Biol. 25, 133 (2008)]. Our results have important practical applications in cases where electrically silent sources that generate measurable magnetic fields are of interest. Moreover, electrically silent, magnetically active moments of higher order can be useful when cancellation due to superposition of fields can occur, since this situation leads to a substantial reduction in the measurable amplitude of the signal. In this context, information derived from magnetic recordings of electrically silent, magnetically active multipoles can supplement electrical recordings for the purpose of studying the physiology of the brain. Magnetic fields of the electric multipole sources in a conducting medium surrounded by an insulating spherical shell are also presented and the relevance of this calculation to cardiographic and encephalographic experimentation is discussed.

  11. Beyond 2D: Parallel Electric Fields and Dissipation in Guide Field Reconnectio

    NASA Astrophysics Data System (ADS)

    Wilder, F. D.; Ergun, R.; Ahmadi, N.; Goodrich, K.; Eriksson, S.; Shimoda, E.; Burch, J. L.; Phan, T.; Torbert, R. B.; Strangeway, R. J.; Giles, B. L.; Lindqvist, P. A.; Khotyaintsev, Y. V.

    2017-12-01

    In 2015, NASA launched the Magnetospheric Multiscale (MMS) mission to study phenomenon of magnetic reconnection down to the electron scale. Advantages of MMS include a 20s spin period and long axial booms, which together allow for measurement of 3-D electric fields with accuracy down to 1 mV/m. During the two dayside phases of the prime mission, MMS has observed multiple electron and ion diffusion region events at the Earth's subsolar and flank magnetopause, as well as in the magnetosheath, providing an option to study both symmetric and asymmetric reconnection at a variety of guide field strengths. We present a review of parallel electric fields observed by MMS during diffusion region events, and discuss their implications for simulations and laboratory observations of reconnection. We find that as the guide field increases, the dissipation in the diffusion region transitions from being due to currents and fields perpendicular to the background magnetic field, to being associated with parallel electric fields and currents. Additionally, the observed parallel electric fields are significantly larger than those predicted by simulations of reconnection under strong guide field conditions.

  12. Colloidal particle electrorotation in a nonuniform electric field

    NASA Astrophysics Data System (ADS)

    Hu, Yi; Vlahovska, Petia M.; Miksis, Michael J.

    2018-01-01

    A model to study the dynamics of colloidal particles in nonuniform electric fields is proposed. For an isolated sphere, the conditions and threshold for sustained (Quincke) rotation in a linear direct current (dc) field are determined. Particle dynamics becomes more complex with increasing electric field strength, changing from steady spinning around the particle center to time-dependent orbiting motion around the minimum field location. Pairs of particles exhibit intricate trajectories, which are a combination of translation, due to dielectrophoresis, and rotation, due to the Quincke effect. Our model provides a basis to study the collective dynamics of many particles in a general electric field.

  13. Colloidal particle electrorotation in a nonuniform electric field.

    PubMed

    Hu, Yi; Vlahovska, Petia M; Miksis, Michael J

    2018-01-01

    A model to study the dynamics of colloidal particles in nonuniform electric fields is proposed. For an isolated sphere, the conditions and threshold for sustained (Quincke) rotation in a linear direct current (dc) field are determined. Particle dynamics becomes more complex with increasing electric field strength, changing from steady spinning around the particle center to time-dependent orbiting motion around the minimum field location. Pairs of particles exhibit intricate trajectories, which are a combination of translation, due to dielectrophoresis, and rotation, due to the Quincke effect. Our model provides a basis to study the collective dynamics of many particles in a general electric field.

  14. Conductivity of molten sodium chloride in an arbitrarily weak dc electric field.

    PubMed

    Delhommelle, Jerome; Cummings, Peter T; Petravic, Janka

    2005-09-15

    We use nonequilibrium molecular-dynamics (NEMD) simulations to characterize the response of a fluid subjected to an electric field. We focus on the response for very weak fields. Fields accessible by conventional NEMD methods are typically of the order of 10(9) V m(-1), i.e., several orders of magnitude larger than those typically used in experiments. Using the transient time-correlation function, we show how NEMD simulations can be extended to study systems subjected to a realistic dc electric field. We then apply this approach to study the response of molten sodium chloride for a wide range of dc electric fields.

  15. Inner Magnetospheric Electric Fields Derived from IMAGE EUV

    NASA Technical Reports Server (NTRS)

    Gallagher, D. L.; Adrian, M. L.

    2007-01-01

    The local and global patterns of plasmaspheric plasma transport reflect the influence of electric fields imposed by all sources in the inner magnetosphere. Image sequences of thermal plasma G:istribution obtained from the IMAGE Mission Extreme Ultraviolet Imager can be used to derive plasma motions and, using a magnetic field model, the corresponding electric fields. These motions and fields directly reflect the dynamic coupling of injected plasmasheet plasma and the ionosphere, in addition to solar wind and atmospheric drivers. What is being learned about the morphology of inner magnetospheric electric fields during storm and quite conditions from this new empirical tool will be presented and discussed.

  16. Effect of external electric and magnetic field on propagation of atmospheric pressure plasma jet

    NASA Astrophysics Data System (ADS)

    Zhu, Ping; Meng, Zhaozhong; Hu, Haixin; Ouyang, Jiting

    2017-10-01

    The behaviors of atmospheric pressure plasma jet produced by a coplanar dielectric barrier discharge (CDBD) in helium in external electrostatic and magnetic field are investigated experimentally. Time-resolved ICCD images of jet in electric field, magnetic field, and floating metal ring are recorded, respectively. The results show that the jet dynamics is affected significantly by a metal ring, an electric, and/or a magnetic field. In a transverse electric field, the jet shows behavior of deflection, broadening, and shortening according to the structure of electric field. In a transverse magnetic field, the jet deflects to up or down depending on the magnetic direction. The jet can be slowed down or obstructed by a floating metal ring on the jet path, but will still pass through the tube at higher applied voltages of DBD, without significant change in jet length or shape out of the tube compared with that without metal ring. A positive DC voltage on the metal ring helps to improve the jet length, but a negative voltage will reduce the length or completely stop the jet. The electric field to sustain the jet in helium is estimated to be about 24 ± 15 kV/cm from this experiment.

  17. Bubble Detachment in Variable Gravity Under the Influence of a Non-Uniform Electric Field

    NASA Technical Reports Server (NTRS)

    Chang, Shinan; Herman, Cila; Iacona, Estelle

    2002-01-01

    The objective of the study reported in this paper is to investigate the effects of variable, reduced gravity on the formation and detachment behavior of individual air bubbles under the influence of a non-uniform electric field. For this purpose, variable gravity experiments were carried out in parabolic nights. The non-uniform electric field was generated by a spherical electrode and a plate electrode. The effect of the magnitude of the non-uniform electric field and gravity level on bubble formation, development and detachment at an orifice was investigated. An image processing code was developed that allows the measurement of bubble volume, dimensions and contact angle at detachment. The results of this research can be used to explore the possibility of enhancing boiling heat transfer in the variable and low gravity environments by substituting the buoyancy force with a force induced by the electric field. The results of experiments and measurements indicate that the level of gravity significantly affects bubble shape, size and frequency. The electric field magnitude also influences bubble detachment, however, its impact is not as profound as that of variable gravity for the range of electric field magnitudes investigated in the present study.

  18. Statistical analysis of electric field parameters for negative lightning in Malaysia

    NASA Astrophysics Data System (ADS)

    Wooi, Chin-Leong; Abdul-Malek, Zulkurnain; Ahmad, Noor-Azlinda; El Gayar, Ali I.

    2016-08-01

    This paper presents a comparative study on the electric field and its derivative parameters of negative lightning in Malaysia and other regions. This study is the first in Malaysia where the parameters of negative electric field and its derivative are thoroughly analyzed. 104 negative lightning flashes containing 277 negative return strokes occurring within 10-100 km from the measuring station and recorded during monsoon period in the state of Johor, Malaysia had been analyzed. It was found that 73% of the recorded flashes are multiple strokes with an average multiplicity of 2.6 strokes per flash. For first return strokes, the arithmetic mean (AM) of initial peak electric field and the AM of initial peak electric field derivative are 21.8 V/m and 11.3 V/m/μs, respectively. The initial peaks of electric field and its derivative for first return strokes are larger than those for the subsequent return strokes. Comparison of overall results with those obtained earlier in Sri Lanka, Germany, Sweden, Japan, Florida indicates that several electric field and its derivative parameters are affected by propagation media and geographical region. Similarity of results with other countries having the same climatic condition is also observed.

  19. Electric field strength determination in filamentary DBDs by CARS-based four-wave mixing

    NASA Astrophysics Data System (ADS)

    Boehm, Patrick; Kettlitz, Manfred; Brandenburg, Ronny; Hoeft, Hans; Czarnetzki, Uwe

    2016-09-01

    The electric field strength is a basic parameter of non-thermal plasmas. Therefore, a profound knowledge of the electric field distribution is crucial. In this contribution a four wave mixing technique based on Coherent Anti-Stokes Raman spectroscopy (CARS) is used to measure electric field strengths in filamentary dielectric barrier discharges (DBDs). The discharges are operated with a pulsed voltage in nitrogen at atmospheric pressure. Small amounts hydrogen (10 vol%) are admixed as tracer gas to evaluate the electric field strength in the 1 mm discharge gap. Absolute values of the electric field strength are determined by calibration of the CARS setup with high voltage amplitudes below the ignition threshold of the arrangement. Alteration of the electric field strength has been observed during the internal polarity reversal and the breakdown process. In this case the major advantage over emission based methods is that this technique can be used independently from emission, e.g. in the pre-phase and in between two consecutive, opposite discharge pulses where no emission occurs at all. This work was supported by the Deutsche Forschungsgemeinschaft, Forschergruppe FOR 1123 and Sonderforschungsbereich TRR 24 ``Fundamentals of complex plasmas''.

  20. Electrohydrodynamics in nanochannels coated by mixed polymer brushes: effects of electric field strength and solvent quality

    NASA Astrophysics Data System (ADS)

    Cao, Qianqian; Tian, Xiu; You, Hao

    2018-04-01

    We examine the electrohydrodynamics in mixed polymer brush-coated nanochannels and the conformational dynamics of grafted polymers using molecular dynamics simulations. Charged (A) and neutral polymers (B) are alternately grafted on the channel surfaces. The effects of the electric field strength and solvent quality are addressed in detail. The dependence of electroosmotic flow characteristics and polymer conformational behavior on the solvent quality is influenced due to the change of the electric field strength. The enhanced electric field induces a collapse of the neutral polymer chains which adopt a highly extended conformation along the flow direction. However, the thickness of the charged polymer layer is affected weakly by the electric field, and even a slight swelling is identified for the A-B attraction case, implying the conformational coupling between two polymer species. Furthermore, the charged polymer chains incline entirely towards the electric field direction oppositely to the flow direction. More importantly, unlike the neutral polymer chains, the shape factor of the charged polymer chains, which is used to describe the overall shape of polymer chains, is reduced significantly with increasing the electric field strength, corresponding to a more coiled structure.

  1. External electric field driven modification of the anomalous and spin Hall conductivities in Fe thin films on MgO(001)

    NASA Astrophysics Data System (ADS)

    Pradipto, Abdul-Muizz; Akiyama, Toru; Ito, Tomonori; Nakamura, Kohji

    2018-01-01

    The effects of applying external electric fields to the anomalous and spin Hall conductivities in Fe thin-film models with different layer thicknesses on MgO(001) are investigated by using first-principles calculations. We observe that, for the considered systems, the application of positive electric field associated with the accumulation of negative charges on the Fe side generally decreases (increases) the anomalous (spin) Hall conductivities. The mapping of the Hall conductivities within the two-dimensional Brillouin zone shows that the electric-field-induced modifications are related to the modification of the band structures of the atoms at the interface with the MgO substrate. In particular, the external electric field affects the Hall conductivities via the modifications of the dx z,dy z orbitals, in which the application of positive electric field pushes the minority-spin states of the dx z,dy z bands closer to the Fermi level. Better agreement with the anomalous Hall conductivity for bulk Fe and a more realistic scenario for the electric field modification of Hall conductivities are obtained by using the thicker layers of Fe on MgO (Fe3/MgO and Fe5/MgO).

  2. Analysis of the contributions of ring current and electric field effects to the chemical shifts of RNA bases.

    PubMed

    Sahakyan, Aleksandr B; Vendruscolo, Michele

    2013-02-21

    Ring current and electric field effects can considerably influence NMR chemical shifts in biomolecules. Understanding such effects is particularly important for the development of accurate mappings between chemical shifts and the structures of nucleic acids. In this work, we first analyzed the Pople and the Haigh-Mallion models in terms of their ability to describe nitrogen base conjugated ring effects. We then created a database (DiBaseRNA) of three-dimensional arrangements of RNA base pairs from X-ray structures, calculated the corresponding chemical shifts via a hybrid density functional theory approach and used the results to parametrize the ring current and electric field effects in RNA bases. Next, we studied the coupling of the electric field and ring current effects for different inter-ring arrangements found in RNA bases using linear model fitting, with joint electric field and ring current, as well as only electric field and only ring current approximations. Taken together, our results provide a characterization of the interdependence of ring current and electric field geometric factors, which is shown to be especially important for the chemical shifts of non-hydrogen atoms in RNA bases.

  3. Influence of Electric Fields and Conductivity on Pollen Tube Growth assessed via Electrical Lab-on-Chip

    PubMed Central

    Agudelo, Carlos; Packirisamy, Muthukumaran; Geitmann, Anja

    2016-01-01

    Pollen tubes are polarly growing plant cells that are able to rapidly respond to a combination of chemical, mechanical, and electrical cues. This behavioural feature allows them to invade the flower pistil and deliver the sperm cells in highly targeted manner to receptive ovules in order to accomplish fertilization. How signals are perceived and processed in the pollen tube is still poorly understood. Evidence for electrical guidance in particular is vague and highly contradictory. To generate reproducible experimental conditions for the investigation of the effect of electric fields on pollen tube growth we developed an Electrical Lab-on-Chip (ELoC). Pollen from the species Camellia displayed differential sensitivity to electric fields depending on whether the entire cell or only its growing tip was exposed. The response to DC fields was dramatically higher than that to AC fields of the same strength. However, AC fields were found to restore and even promote pollen growth. Surprisingly, the pollen tube response correlated with the conductivity of the growth medium under different AC frequencies—consistent with the notion that the effect of the field on pollen tube growth may be mediated via its effect on the motion of ions. PMID:26804186

  4. Modeling the Adsorbate Coverage Distribution Over a Multi-Faceted Catalytic Grain in the Presence of an Electric Field: O/Fe from First Principles

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bray, Jacob; Hensley, Alyssa J. R.; Collinge, Greg

    The impact of an external electric field on the concerted behavior of oxygen over a multi-faceted catalytic Fe grain is determined via the interpolation of ab initio models of oxygen adsorption on Fe(100), Fe(110), and Fe(111) in the presence of an external electric field. The application of both negative and positive electric fields weaken the adsorption strength for oxygen on all three surface facets, with Fe(110) experiencing the greatest effect. Kinetic models of a multi-faceted catalytic Fe grain show that the average oxygen coverage over the grain surface is reduced under the influence of both a negative and positive electricmore » field, which are consistent with phase diagram results at comparable pressures. Furthermore, we show that there is a weak synergistic effect between a Pd promoter and a positive electric field on the oxygen adsorption energy, i.e. the Pd promoter and electric field combination weaken the oxygen adsorption energy to a greater degree than the simple addition of both components separately. In conclusion, the work shows that the application of an applied external electric field may be a useful tool in fine-tuning chemical properties of Fe-based catalysts in hydrodeoxygenation applications.« less

  5. Modeling the Adsorbate Coverage Distribution Over a Multi-Faceted Catalytic Grain in the Presence of an Electric Field: O/Fe from First Principles

    DOE PAGES

    Bray, Jacob; Hensley, Alyssa J. R.; Collinge, Greg; ...

    2018-04-15

    The impact of an external electric field on the concerted behavior of oxygen over a multi-faceted catalytic Fe grain is determined via the interpolation of ab initio models of oxygen adsorption on Fe(100), Fe(110), and Fe(111) in the presence of an external electric field. The application of both negative and positive electric fields weaken the adsorption strength for oxygen on all three surface facets, with Fe(110) experiencing the greatest effect. Kinetic models of a multi-faceted catalytic Fe grain show that the average oxygen coverage over the grain surface is reduced under the influence of both a negative and positive electricmore » field, which are consistent with phase diagram results at comparable pressures. Furthermore, we show that there is a weak synergistic effect between a Pd promoter and a positive electric field on the oxygen adsorption energy, i.e. the Pd promoter and electric field combination weaken the oxygen adsorption energy to a greater degree than the simple addition of both components separately. In conclusion, the work shows that the application of an applied external electric field may be a useful tool in fine-tuning chemical properties of Fe-based catalysts in hydrodeoxygenation applications.« less

  6. Comparison of in-situ Electric Field and Radar Derived Parameters for Stratiform Clouds in Central Florida

    NASA Astrophysics Data System (ADS)

    Bateman, M.; Mach, D.; Lewis, S.; Dye, J.; Defer, E.; Grainger, C.; Willis, P.; Christian, H.; Merceret, F.

    2003-12-01

    Airborne measurements of electric fields and particle microphysics were made during a field program at NASA's Kennedy Space Center. The aircraft, a Cessna Citation II jet operated by the University of North Dakota, carried six rotating-vane style electric field mills, several microphysics instruments, and thermodynamic instruments. In addition to the aircraft measurements, we also have data from both the Eastern Test Range WSR-74C (Patrick AFB) and the U.S. National Weather Service WSR-88D radars (primarily Melbourne, FL). One specific goal of this program was to try to develop a radar-based rule for estimating the hazard that an in-cloud electric field would present to a vehicle launched into the cloud. Based on past experience, and our desire to quantify the mixed-phase region of the cloud in question, we have assessed several algorithms for integrating radar reflectivity data in and above the mixed-phase region as a proxy for electric field. A successful radar proxy is one that can accurately predict the presence or absence of significant electric fields. We have compared various proxies with the measured in-cloud electric field strength in an attempt to develop a radar rule for assessing launch hazard. Assessment of the best proxy is presented.

  7. Communication: Influence of external static and alternating electric fields on water from long-time non-equilibrium ab initio molecular dynamics

    NASA Astrophysics Data System (ADS)

    Futera, Zdenek; English, Niall J.

    2017-07-01

    The response of water to externally applied electric fields is of central relevance in the modern world, where many extraneous electric fields are ubiquitous. Historically, the application of external fields in non-equilibrium molecular dynamics has been restricted, by and large, to relatively inexpensive, more or less sophisticated, empirical models. Here, we report long-time non-equilibrium ab initio molecular dynamics in both static and oscillating (time-dependent) external electric fields, therefore opening up a new vista in rigorous studies of electric-field effects on dynamical systems with the full arsenal of electronic-structure methods. In so doing, we apply this to liquid water with state-of-the-art non-local treatment of dispersion, and we compute a range of field effects on structural and dynamical properties, such as diffusivities and hydrogen-bond kinetics.

  8. MEASUREMENT OF SMALL MECHANICAL VIBRATIONS OF BRAIN TISSUE EXPOSED TO EXTREMELY-LOW-FREQUENCY ELECTRIC FIELDS

    EPA Science Inventory

    Electromagnetic fields can interact with biological tissue both electrically and mechanically. This study investigated the mechanical interaction between brain tissue and an extremely-low-frequency (ELF) electric field by measuring the resultant vibrational amplitude. The exposur...

  9. Comparison of fast electric field changes from subsequent return strokes of natural and triggered lightning

    NASA Technical Reports Server (NTRS)

    Le Vine, D. M.; Willett, J.

    1988-01-01

    Fast electric field changes from subsequent return strokes of natural and triggered lightning with propagation paths almost entirely over water are compared. Data were collected at the Kennedy Space Center, Florida. Comparisons have been made of the average shape, the rise time and the spectrum of the electric field changes. The electric field changes from the triggered flashes tend to rise to peak faster and decay faster than do their counterparts in natural cloud-to-ground flashes.

  10. Effect of electric field on the magnetic characteristics of a ferromagnetic nanosemiconductor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kozhushner, M. A., E-mail: kozhushner@gmail.com; Lidskii, B. V.; Posvyanskii, V. S.

    A theory is developed to describe the effect of an electric field on the magnetization of a thin ferromagnetic semiconductor plate. It is shown that the magnetic moment density is nonuniform under these conditions and that the total magnetic moment and its density depend on the electric field and the temperature. An electric field is found to increase the Curie temperature, and an inflection point is detected in the temperature dependence of the derivative of the total magnetic moment with respect to temperature.

  11. High dynamic range electric field sensor for electromagnetic pulse detection.

    PubMed

    Lin, Che-Yun; Wang, Alan X; Lee, Beom Suk; Zhang, Xingyu; Chen, Ray T

    2011-08-29

    We design a high dynamic range electric field sensor based on domain inverted electro-optic (E-O) polymer Y-fed directional coupler for electromagnetic wave detection. This electrode-less, all optical, wideband electrical field sensor is fabricated using standard processing for E-O polymer photonic devices. Experimental results demonstrate effective detection of electric field from 16.7V/m to 750KV/m at a frequency of 1GHz, and spurious free measurement range of 70dB.

  12. The Study for Shortening the Process Time at Soy Food Production by using the Pulsed Electric Field

    NASA Astrophysics Data System (ADS)

    Saito, Tsukasa; Jinushi, Makoto; Minamitani, Yasushi

    We investigated method to osmose water and seasoner to dried soybeans fast by pulsed electric field, in order to make soybeans a processed food fast. By applying the pulsed electric field to the dried soybeans in water, osmosis time of water to the soybean became approximately half. Then the emission of the discharge was observed on dried soybean. The color of coffee permeated more into the soybean treated than no-treated by the pulsed electric field.

  13. Electric fields and conductivity in the nighttime E-region - A new magnetosphere-ionosphere-atmosphere coupling effect

    NASA Technical Reports Server (NTRS)

    Banks, P. M.; Yasuhara, F.

    1978-01-01

    Calculations have been made of the effects of intense poleward-directed electric fields upon the nighttime ionospheric E-region. The results show the Pedersen and Hall conductivities are substantially changed, thereby decreasing the ionospheric electrical load seen by magnetospheric sources. It appears that relatively large electric fields can exist in the absence of accompanying large field-aligned currents, as long as the underlying ionosphere remains in darkness and/or energetic particle precipitation is absent.

  14. International Conference on Quantum Chemical Calculations of NMR and EPR Parameters Held in Castle Smolenice, Slovak Republic on September 14-18 1998

    DTIC Science & Technology

    1998-10-21

    site. The electric-field- induced linear shift is also observed in the hyperfine splitting of nuclear quadrupole resonance ( NQR ) spectrum of a nucleus...located at a noncentrosymmetric site in a molecule or in crystal lattice. Thus, the linear electric field effect on the ESR and NQR hyperfine splitting...the electric field effects on ESR and NQR hyperfine couplings. Theoretical methods to calculate the electric field effects within Hartree-Fock

  15. Simulation study on electric field intensity above train roof

    NASA Astrophysics Data System (ADS)

    Fan, Yizhe; Li, Huawei; Yang, Shasha

    2018-04-01

    In order to understand the distribution of electric field in the space above the train roof accurately and select the installation position of the detection device reasonably, in this paper, the 3D model of pantograph-catenary is established by using SolidWorks software, and the spatial electric field distribution of pantograph-catenary model is simulated based on Comsol software. According to the electric field intensity analysis within the 0.4m space above train roof, we give a reasonable installation of the detection device.

  16. Melatonin Regulates Daily Variations in Electric Behavior Arousal in Two Species of Weakly Electric Fish with Different Social Structures.

    PubMed

    Migliaro, Adriana; Silva, Ana

    2016-01-01

    Timing is crucial for social interactions. Animal behavior is synchronized with biotic and abiotic environment variables ensuring that the activity phase of conspecifics occurs during the same period of the day. As biological rhythms are embedded in the complex integrative control of the brain, it is fundamental to explore its interaction with environmental and social factors. This approach will unravel the link between external stimuli carrying information on environmental cycles and the neural commands for behavior, including social behavior, associated with precise phases of those cycles. Arousal in the solitary Gymnotus omarorum and in the gregarious Brachyhypopomus gauderio is characterized by a nocturnal increase in the basal discharge rate of electric behavior, which is mild and transient in G. omarorum and large and persistent in B. gauderio. In this study, we show that the major integrator of social behavior, AVT (arginine vasotocin), is not involved in the nocturnal increase of electric behavior basal rate in isolated animals of either species. On the other hand, endogenous melatonin, the major modulator of the circadian system, is responsible for the nocturnal increase in electric behavior in isolated individuals of both species. © 2016 S. Karger AG, Basel.

  17. ROCSAT and HF Doppler sounder observations of the DP2-type electric field during the global Pc5 magnetic pulsation event

    NASA Astrophysics Data System (ADS)

    Hashimoto, K. K.; Kikuchi, T.; Nagatsuma, T.; Tomizawa, I.

    2016-12-01

    During the stormtime Pc5 magnetic pulsations on 31 October 2003, we detected large amplitude oscillations in the ionospheric electric field with the HF Doppler sounders at midlatitude for 10 hours from 11 to 21 LT. Similar oscillations were recorded on the magnetometer data at high-to-equatorial latitudes with significant amplitude enhancement at the dayside equator. We deduced the equatorial electrojet (EEJ) by subtracting the low latitude Pc5 from the equatorial Pc5 and found that the midlatitude electric field (EF) is well correlated with the EEJ with correlation coefficients (0.80-0.95) and that the EEJ to EF ratio reached maximum at 11 LT and dramatically decreased until 18 LT in a function of cos0.6(solar zenith angle). With these observations, we suggest that the midlatitude electric field (EF) is associated with the DP2 type ionospheric currents transmitted from high latitude to the equator. It is to be noted that the EF is well correlated with the EEJ during the night after 18 LT, indicating that the Pc5 electric field is so strong as to drive equatorial electrojet in the nighttime ionosphere. Using the electric field measured by ROCSAT-1/IPEI, we confirmed that the Pc5 electric field in the mid- and low-latitude ionosphere is comparable to or even stronger than those observed by the HF Doppler sounders. High correlations between the ground- and satellite-based observations over 15 minutes indicate that the Pc5 electric field distribute uniform over 6500 km along the ROCSAT orbit which is consistent with the large-scale DP2 electric field.

  18. Electro-aerodynamic field aided needleless electrospinning.

    PubMed

    Yan, Guilong; Niu, Haitao; Zhou, Hua; Wang, Hongxia; Shao, Hao; Zhao, Xueting; Lin, Tong

    2018-06-08

    Auxiliary fields have been used to enhance the performance of needle electrospinning. However, much less has been reported on how auxiliary fields affect needleless electrospinning. Herein, we report a novel needleless electrospinning technique that consists of an aerodynamic field and a second electric field. The second electric field is generated by setting two grounded inductive electrodes near the spinneret. The two auxiliary fields have to be applied simultaneously to ensure working of the electrospinning process. A synergistic effect was observed between inductive electrode and airflow. The aerodynamic-electric auxiliary field was found to significantly increase fiber production rate (4.5 g h -1 ), by 350% in comparison to the setup without auxiliary field (1.0 g h -1 ), whereas it had little effect on fiber diameter. The auxiliary fields allow running needleless electrospinning at an applied voltage equivalent to that in needle electrospinning (e.g. 10-30 kV). The finite element analyses of electric field and airflow field verify that the inductive electrodes increase electric field strength near the spinneret, and the airflow assists in fiber deposition. This novel needleless electrospinning may be useful for development of high-efficiency, low energy-consumption nanofiber production systems.

  19. Electro-aerodynamic field aided needleless electrospinning

    NASA Astrophysics Data System (ADS)

    Yan, Guilong; Niu, Haitao; Zhou, Hua; Wang, Hongxia; Shao, Hao; Zhao, Xueting; Lin, Tong

    2018-06-01

    Auxiliary fields have been used to enhance the performance of needle electrospinning. However, much less has been reported on how auxiliary fields affect needleless electrospinning. Herein, we report a novel needleless electrospinning technique that consists of an aerodynamic field and a second electric field. The second electric field is generated by setting two grounded inductive electrodes near the spinneret. The two auxiliary fields have to be applied simultaneously to ensure working of the electrospinning process. A synergistic effect was observed between inductive electrode and airflow. The aerodynamic-electric auxiliary field was found to significantly increase fiber production rate (4.5 g h‑1), by 350% in comparison to the setup without auxiliary field (1.0 g h‑1), whereas it had little effect on fiber diameter. The auxiliary fields allow running needleless electrospinning at an applied voltage equivalent to that in needle electrospinning (e.g. 10–30 kV). The finite element analyses of electric field and airflow field verify that the inductive electrodes increase electric field strength near the spinneret, and the airflow assists in fiber deposition. This novel needleless electrospinning may be useful for development of high-efficiency, low energy-consumption nanofiber production systems.

  20. Electroosmotic Flow Driven by DC and AC Electric Fields in Curved Microchannels

    NASA Astrophysics Data System (ADS)

    Chen, Jia-Kun; Luo, Win-Jet; Yang, Ruey-Jen

    2006-10-01

    The purpose of this study is to investigate electroosmotic flows driven by externally applied DC and AC electric fields in curved microchannels. For the DC electric driving field, the velocity distribution and secondary flow patterns are investigated in microchannels with various curvature ratios. We use the Dean number to describe the curvature effect of the flow field in DC electric field. The result implies that the effect of curvatures and the strength of the secondary flows become get stronger when the curvature ratio of C/A (where C is the radius of curvature of the microchannel and A is the half-height of rectangular curved tube.) is smaller. For the AC electric field, the velocity distribution and secondary flow patterns are investigated for driving frequencies in the range of 2.0 kHz (\\mathit{Wo}=0.71) to 11 kHz (\\mathit{Wo}=1.66). The numerical results reveal that the velocity at the center of the microchannel becomes lower at higher frequencies of the AC electric field and the strength of the secondary flow decreases. When the applied frequency exceeds 3.0 kHz (\\mathit{Wo}=0.87), vortices are no longer observed at the corners of the microchannel. Therefore, it can be concluded that the secondary flow induced at higher AC electric field frequencies has virtually no effect on the axial flow field in the microchannel.

  1. Electric field measurements during the Condor critical velocity experiment

    NASA Technical Reports Server (NTRS)

    Kelley, M. C.; Pfaff, R. F.; Haerendel, G.

    1986-01-01

    The instrumentation of the Condor critical velocity Ba experiment (Wescott et al., 1986) for the measurements of the energetic particles and the electric field associated with a Ba explosion is described. The Ba explosion created a complex electric field pulse detected in situ by a single-axis double electric-field probe on a separate spacecraft. The measurements provide evidence of several important links in the critical-velocity chain, and are consistent with two hypotheses. The first hypothesis involves the creation of large polarization electric field due to charge separation; the second hypothesis implies a polarization of the beam by currents flowing across it. The chain of physical processes inferred from the observations is in agreement with most theories for the Alfven process.

  2. Propagation characteristics of a focused laser beam in a strontium barium niobate photorefractive crystal under reverse external electric field.

    PubMed

    Guo, Q L; Liang, B L; Wang, Y; Deng, G Y; Jiang, Y H; Zhang, S H; Fu, G S; Simmonds, P J

    2014-10-01

    The propagation characteristics of a focused laser beam in a SBN:75 photorefractive crystal strongly depend on the signal-to-background intensity ratio (R=Is/Ib) under reverse external electric field. In the range 20>R>0.05, the laser beam shows enhanced self-defocusing behavior with increasing external electric field, while it shows self-focusing in the range 0.03>R>0.01. Spatial solitons are observed under a suitable reverse external electric field for R=0.025. A theoretical model is proposed to explain the experimental observations, which suggest a new type of soliton formation due to "enhancement" not "screening" of the external electrical field.

  3. Simulations of electrically induced particle structuring on spherical drop surface

    NASA Astrophysics Data System (ADS)

    Hu, Yi; Vlahovska, Petia; Miksis, Michael

    2016-11-01

    Recent experiments (Ouriemi and Vlahovska, 2014) show intriguing surface patterns when a uniform electric field is applied to a droplet covered with colloidal particles. Depending on the particle properties and the electrical field intensity, particles organize into an equatorial belt, pole-to-pole chains, or dynamic vortices. Here we present a model to simulate the collective particle dynamics, which accounts for the electrohydrodynamic flow and particle dielectrophoresis due to the non-uniformity of local electrical field. In stronger electric fields, particles are expected to undergo Quincke rotation, inducing rotating clusters through inter-particle hydrodynamical interaction. We discuss how the field intensity influences the width, orientation and periodicity of the particle clusters. Our results provide insight into the various particle assembles discovered in the experiments.

  4. Influence of bias electric field on elastic waves propagation in piezoelectric layered structures.

    PubMed

    Burkov, S I; Zolotova, O P; Sorokin, B P

    2013-08-01

    Theoretical and computer investigations of acoustic wave propagation in piezoelectric layered structures, subjected to the dc electric field influence have been fulfilled. Analysis of the dispersive parameters of elastic waves propagation in the BGO/fused silica and fused silica/LiNbO3 piezoelectric layered structures for a number of variants of dc electric field application has been executed. Transformation of bulk acoustic wave into SAW type mode under the dc electric field influence has been found. Possibility to control the permission or prohibition of the wave propagation by the dc electric field application and the appropriate choice of the layer and substrate materials has been discussed. Copyright © 2013 Elsevier B.V. All rights reserved.

  5. Electrical tuning of spin splitting in Bi-doped ZnO nanowires

    NASA Astrophysics Data System (ADS)

    Aras, Mehmet; Kılıç, ćetin

    2018-01-01

    The effect of applying an external electric field on doping-induced spin-orbit splitting of the lowest conduction-band states in a bismuth-doped zinc oxide nanowire is studied by performing electronic structure calculations within the framework of density functional theory. It is demonstrated that spin splitting in Bi-doped ZnO nanowires could be tuned and enhanced electrically via control of the strength and direction of the applied electric field, thanks to the nonuniform and anisotropic response of the ZnO:Bi nanowire to external electric fields. The results reported here indicate that a single ZnO nanowire doped with a low concentration of Bi could function as a spintronic device, the operation of which is controlled by applied lateral electric fields.

  6. Optical Limiting Using the Two-Photon Absorption Electrical Modulation Effect in HgCdTe Photodiode

    PubMed Central

    Cui, Haoyang; Yang, Junjie; Zeng, Jundong; Tang, Zhong

    2013-01-01

    The electrical modulation properties of the output intensity of two-photon absorption (TPA) pumping were analyzed in this paper. The frequency dispersion dependence of TPA and the electric field dependence of TPA were calculated using Wherrett theory model and Garcia theory model, respectively. Both predicted a dramatic variation of TPA coefficient which was attributed into the increasing of the transition rate. The output intensity of the laser pulse propagation in the pn junction device was calculated by using function-transfer method. It shows that the output intensity increases nonlinearly with increasing intensity of incident light and eventually reaches saturation. The output saturation intensity depends on the electric field strength; the greater the electric field, the smaller the output intensity. Consequently, the clamped saturation intensity can be controlled by the electric field. The prior advantage of electrical modulation is that the TPA can be varied extremely continuously, thus adjusting the output intensity in a wide range. This large change provides a manipulate method to control steady output intensity of TPA by adjusting electric field. PMID:24198721

  7. Hall effect in the presence of rotation

    NASA Astrophysics Data System (ADS)

    Zubkov, M. A.

    2018-02-01

    A rotating relativistic fermion system is considered. The consideration is based on the Dirac equation written in the laboratory (non-rotating) reference frame. Rotation in this approach gives rise to the effective magnetic and electric fields that act in the same way both on positive and negative electric charges. In the presence of external electric field in the given system the electric current appears orthogonal to both the electric field and the axis of rotation. The possible applications to the physics of quark-gluon plasma are discussed.

  8. Thermal to electricity conversion using thermal magnetic properties

    DOEpatents

    West, Phillip B [Idaho Falls, ID; Svoboda, John [Idaho Falls, ID

    2010-04-27

    A system for the generation of Electricity from Thermal Energy using the thermal magnetic properties of a Ferromagnetic, Electrically Conductive Material (FECM) in one or more Magnetic Fields. A FECM is exposed to one or more Magnetic Fields. Thermal Energy is applied to a portion of the FECM heating the FECM above its Curie Point. The FECM, now partially paramagnetic, moves under the force of the one or more Magnetic Fields. The movement of the FECM induces an electrical current through the FECM, generating Electricity.

  9. Computational estimation of magnetically induced electric fields in a rotating head

    NASA Astrophysics Data System (ADS)

    Ilvonen, Sami; Laakso, Ilkka

    2009-01-01

    Change in a magnetic field, or similarly, movement in a strong static magnetic field induces electric fields in human tissues, which could potentially cause harmful effects. In this paper, the fields induced by different rotational movements of a head in a strong homogeneous magnetic field are computed numerically. Average field magnitudes near the retinas and inner ears are studied in order to gain insight into the causes of phosphenes and vertigo-like effects, which are associated with extremely low-frequency (ELF) magnetic fields. The induced electric fields are calculated in four different anatomically realistic head models using an efficient finite-element method (FEM) solver. The results are compared with basic restriction limits by IEEE and ICNIRP. Under rotational movement of the head, with a magnetic flux rate of change of 1 T s-1, the maximum IEEE-averaged electric field and maximum ICNIRP-averaged current density were 337 mV m-1 and 8.84 mA m-2, respectively. The limits by IEEE seem significantly stricter than those by ICNIRP. The results show that a magnetic flux rate of change of 1 T s-1 may induce electric field in the range of 50 mV m-1 near retinas, and possibly even larger values near the inner ears. These results provide information for approximating the threshold electric field values of phosphenes and vertigo-like effects.

  10. Dielectrics for long term space exposure and spacecraft charging: A briefing

    NASA Technical Reports Server (NTRS)

    Frederickson, A. R.

    1989-01-01

    Charging of dielectrics is a bulk, not a surface property. Radiation driven charge stops within the bulk and is not quickly conducted to the surface. Very large electric fields develop in the bulk due to this stopped charge. At space radiation levels, it typically requires hours or days for the internal electric fields to reach steady state. The resulting electric fields are large enough to produce electrical failure within the insulator. This type failure is thought to produce nearly all electric discharge anomalies. Radiation also induces bond breakage, creates reactive radicals, displaces atoms and, in general, severely changes the chemistry of the solid state material. Electric fields can alter this process by reacting with charged species, driving them through the solid. Irradiated polymers often lose as much as a percent of their mass, or more, at exposures typical in space. Very different aging or contaminant emission can be induced by the stopped charge electric fields. These radiation effects are detailed.

  11. Electric field replaces gravity in laboratory

    NASA Astrophysics Data System (ADS)

    Gorgolewski, S.

    For several years experiments in physical laboratories and in the fitotron have shown that one can replace gravitational field with electrical fields for plants. First obvious experiments in strong electrical fields in the MV/m regi on show that any materials and living plants respond immediately to Coulomb forces. Such fields are found in nature during thunderstorms. One has to be very careful in handling such strong fields for safety reasons. The fair weather global electrical field is about 20,000 times weaker. The coulomb forces are proportional to the square of the field strength and are thus 400 milion times weaker for a field of the order of 100 V/m.Yet it was found that some plants respond to such "weak" fields. We must remember that the electrical field is a factor of 10 38 times stronger than gravitational interaction. In plants we have dissociated in water mineral salts and the ions are subject to such ernormous forces. It was shown and published that the positive charges in the air in fields of the order of 3kV/m enhance lettuce growth by a factor of four relative to fields about 30 times weaker (100V/m). Reversal of the field polarity reverses the direction of plant growth and retards the plant's growth. Such fields overpower the gravitropism in the laboratory. More so horizontal electrical field is othogonal to gravity, now the fields do not see each other. Lettuce now growth horizontally ignoring the gravitational field. We can thus select the plants whose electrotropism even in the laboratory overwhelms gravity. This is important for the long space flights that we must grow vegetarian food for the crew. The successful harvesting of wheat in orbit does not contradict our experimental findings because wheat is not electrotropic like all plants from the grass family. The results of fitotron experiments with kV/m electrical fields are richly illustrated with colour digital photographs. We also subjected the candle flame to very strong horizontal electrical fields. The flame splits into two horizontal flames, ignoring the gravitational field in the laboratory. This result is similar to the behaviour of ions in plants which are responsible for the transport of nutrients from the roots to leaves and opposite ions to roots from the leaves. It shows that we can control the transport phenomena in the process of growth in plants as well as of combustion in space with proper electrical fields.

  12. In-plane electric field controlled ferromagnetism and anisotropic magnetoresistance in an LSMO/PMN-PT heterostructure.

    PubMed

    Guo, Qi; Xu, Xiaoguang; Wang, Fang; Lu, Yunhao; Chen, Jikun; Wu, Yanjun; Meng, Kangkang; Wu, Yong; Miao, Jun; Jiang, Yong

    2018-06-01

    We report the in-plane electric field controlled ferromagnetism of La 2/3 Sr 1/3 MnO 3 (LSMO) films epitaxially deposited on [Pb(Mg 1/3 Nb 2/3 )O 3 ] 0.7 -(PbTiO 3 ) 0.3 (PMN-PT) (001), (011) and (111) single crystal substrates. The in-plane coercivities (H c∥ ) and remanences of the LSMO films greatly depend on the in-plane electric field applied on the PMN-PT (001) and (011) substrates. The experimental change of H c∥ is consistent with the Stoner-Wohlfarth model and first principle calculation with the electric field varying from -10 to 10 kV cm -1 . Moreover, the Curie temperature and anisotropic magnetoresistance of the LSMO films can also be manipulated by an in-plane electric field. Finally, the LSMO/PMN-PT (001) heterostructure is designed to be a new kind of magnetic signal generator with the source of electric field.

  13. Simulation of the effects of sub-breakdown electric fields on the chemical kinetics in nonpremixed counterflow methane/air flames

    NASA Astrophysics Data System (ADS)

    Belhi, Memdouh; Im, Hong; Computational Reacting Flows Laboratory, Clean Combustion Research Center Team

    2017-11-01

    The effects of an electric field on the combustion kinetics in nonpremixed counterflow methane/air flames were investigated via one-dimensional numerical simulations. A classical fluid model coupling Poison's equation with transport equations for combustion species and electric field-induced particles was used. A methane-air reaction mechanism accounting for the natural ionization in flames was combined with a set of reactions that describe the formation of active particles induced by the electric field. Kinetic parameters for electron-impact reactions and transport coefficients of electrons were modeled as functions of reduced electric field via solutions to the Boltzmann kinetic equation using the BOLSIG code. Mobility of ions was computed based on the (n,6,4) and coulomb interaction potentials, while the diffusion coefficient was approximated from the mobility using Einstein relation. Contributions of electron dissociation, excitation and ionization processes were characterized quantitatively. An analysis to identify the plasma regime where the electric field can alter the combustion kinetic was proposed.

  14. In-plane electric field controlled ferromagnetism and anisotropic magnetoresistance in an LSMO/PMN-PT heterostructure

    NASA Astrophysics Data System (ADS)

    Guo, Qi; Xu, Xiaoguang; Wang, Fang; Lu, Yunhao; Chen, Jikun; Wu, Yanjun; Meng, Kangkang; Wu, Yong; Miao, Jun; Jiang, Yong

    2018-06-01

    We report the in-plane electric field controlled ferromagnetism of La2/3Sr1/3MnO3 (LSMO) films epitaxially deposited on [Pb(Mg1/3Nb2/3)O3]0.7-(PbTiO3)0.3 (PMN-PT) (001), (011) and (111) single crystal substrates. The in-plane coercivities (H c∥) and remanences of the LSMO films greatly depend on the in-plane electric field applied on the PMN-PT (001) and (011) substrates. The experimental change of H c∥ is consistent with the Stoner–Wohlfarth model and first principle calculation with the electric field varying from ‑10 to 10 kV cm‑1. Moreover, the Curie temperature and anisotropic magnetoresistance of the LSMO films can also be manipulated by an in-plane electric field. Finally, the LSMO/PMN-PT (001) heterostructure is designed to be a new kind of magnetic signal generator with the source of electric field.

  15. Theoretical study of the influence of the electric field on the electronic properties of armchair boron nitride nanoribbon

    NASA Astrophysics Data System (ADS)

    Chegel, Raad; Behzad, Somayeh

    2014-11-01

    We have investigated the electronic properties of A-BNNRs in the external electric field using third nearest neighbor tight binding approximation including edge effects. We found that the dependence of on-site energy to the external electric field for edge atoms and center part atoms is different. By comparing the band structure in the different fields, several differences are clearly seen such as modification of energy dispersions, creation of additional band edge states and band gap reduction. By increasing the electric field the band gap reduces linearly until reaches zero and BNNRs with larger width are more sensitive than small ones. All changes in the band structure are directly reflected in the DOS spectrum. The numbers and the energies of the DOS peaks are dependent on the electric field strength.

  16. Optical Remote Sensing of Electric Fields Above Thunderstorms

    NASA Astrophysics Data System (ADS)

    Burns, B. M.; Carlson, B. E.; Lauben, D.; Cohen, M.; Smith, D.; Inan, U. S.

    2010-12-01

    Measurement of thunderstorm electric fields typically require balloon-borne measurements in the region of interest. Such measurements are cumbersome and provide limited information at a single point. Remote sensing of electric fields by Kerr-effect induced optical polarization changes of background skylight circumvents many of these difficulties and can in principle provide a high-speed movie of electric field behavior. Above-thundercloud 100 kV/m quasi-static electric fields are predicted to produce polarization changes at above the part in one million level that should be detectable at a ground instrument featuring 1 cm2sr geometric factor and 1 kHz bandwidth (though more sensitivity is nonetheless desired). Currently available optical and electronic components may meet these requirements. We review the principles of this measurement and discuss the current status of a field-ready prototype instrument currently in construction.

  17. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lin, Meng-Lin; Peng, J. S.; Lee, Sanboh, E-mail: sblee@mx.nthu.edu.tw

    We studied the digestive ripening of thiol-capped gold nanoparticles under simultaneous action of electric field and reflux heating in a silicone oil bath at 130 °C, using transmission electron microscopy. Observation revealed that a polydispersed gold nanoparticle system reached the state of nearly monodispersity under the action of an electric field and the thiol-capped gold nanoparticles carried negative charges. The electric field caused the increase of the particle size for the nearly monodispersed gold nanoparticle system. The self-assembly of the nearly monodisperse gold nanoparticles under the action of an electric field of a high field intensity was observed. The gold nanoparticlesmore » tended to form self-assembled nanostructures of six-fold symmetry. This study provides a new route for system engineering to control the particle size of metallic nanoparticles by electric field and digestive ripening.« less

  18. Experimental Measurements of the Dynamic Electric Field Topology Associated with Magnetized RF Sheaths

    NASA Astrophysics Data System (ADS)

    Martin, E. H.; Caughman, J. B. O.; Shannon, S. C.; Klepper, C. C.; Isler, R. C.

    2013-10-01

    A major challenge facing magnetic fusion devices and the success of ITER is the design and implementation of reliable ICRH systems. The primary issue facing ICRH is the parasitic near-field which leads to an increased heat flux, sputtering, and arcing of the antenna/faraday screen. In order to aid the theoretical development of near-field physics and thus propel the design process experimental measurements are highly desired. In this work we have developed a diagnostic based on passive emission spectroscopy capable of measuring time periodic electric fields utilizing a generalized dynamic Stark effect model and a novel spectral line profile fitting package. The diagnostic was implemented on a small scale laboratory experiment designed to simulate the edge environment associated with ICRF antenna/faraday screen. The spatially and temporally resolved electric field associated with magnetized RF sheaths will be presented for two field configurations: magnetic field parallel to electric field and magnetic field perpendicular to electric field, both hydrogen and helium discharges where investigated. ORNL is managed by UT-Battelle, LCC, for the US DOE under Contract No. DE-AC05-00OR22725.

  19. Deep-subwavelength imaging of both electric and magnetic localized optical fields by plasmonic campanile nanoantenna

    DOE PAGES

    Caselli, Niccolò; La China, Federico; Bao, Wei; ...

    2015-06-05

    Tailoring the electromagnetic field at the nanoscale has led to artificial materials exhibiting fascinating optical properties unavailable in naturally occurring substances. Besides having fundamental implications for classical and quantum optics, nanoscale metamaterials provide a platform for developing disruptive novel technologies, in which a combination of both the electric and magnetic radiation field components at optical frequencies is relevant to engineer the light-matter interaction. Thus, an experimental investigation of the spatial distribution of the photonic states at the nanoscale for both field components is of crucial importance. Here we experimentally demonstrate a concomitant deep-subwavelength near-field imaging of the electric and magneticmore » intensities of the optical modes localized in a photonic crystal nanocavity. We take advantage of the “campanile tip”, a plasmonic near-field probe that efficiently combines broadband field enhancement with strong far-field to near-field coupling. In conclusion, by exploiting the electric and magnetic polarizability components of the campanile tip along with the perturbation imaging method, we are able to map in a single measurement both the electric and magnetic localized near-field distributions.« less

  20. Electrically tunable hole g factor of an optically active quantum dot for fast spin rotations

    NASA Astrophysics Data System (ADS)

    Prechtel, Jonathan H.; Maier, Franziska; Houel, Julien; Kuhlmann, Andreas V.; Ludwig, Arne; Wieck, Andreas D.; Loss, Daniel; Warburton, Richard J.

    2015-04-01

    We report a large g factor tunability of a single hole spin in an InGaAs quantum dot via an electric field. The magnetic field lies in the in-plane direction x , the direction required for a coherent hole spin. The electrical field lies along the growth direction z and is changed over a large range, 100 kV/cm. Both electron and hole g factors are determined by high resolution laser spectroscopy with resonance fluorescence detection. This, along with the low electrical-noise environment, gives very high quality experimental results. The hole g factor ghx depends linearly on the electric field Fz,d ghx/d Fz=(8.3 ±1.2 ) ×10-4 cm/kV, whereas the electron g factor gex is independent of electric field d gex/d Fz=(0.1 ±0.3 ) ×10-4 cm/kV (results averaged over a number of quantum dots). The dependence of ghx on Fz is well reproduced by a 4 ×4 k .p model demonstrating that the electric field sensitivity arises from a combination of soft hole confining potential, an In concentration gradient, and a strong dependence of material parameters on In concentration. The electric field sensitivity of the hole spin can be exploited for electrically driven hole spin rotations via the g tensor modulation technique and based on these results, a hole spin coupling as large as ˜1 GHz can be envisaged.

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