Science.gov

Sample records for energy supply regulation

  1. Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands

    PubMed Central

    Saks, Valdur; Favier, Roland; Guzun, Rita; Schlattner, Uwe; Wallimann, Theo

    2006-01-01

    This review re-evaluates regulatory aspects of substrate supply in heart. In aerobic heart, the preferred substrates are always free fatty acids, and workload-induced increase in their oxidation is observed at unchanged global levels of ATP, phosphocreatine and AMP. Here, we evaluate the mechanisms of regulation of substrate supply for mitochondrial respiration in muscle cells, and show that a system approach is useful also for revealing mechanisms of feedback signalling within the network of substrate oxidation and particularly for explaining the role of malonyl-CoA in regulation of fatty acid oxidation in cardiac muscle. This approach shows that a key regulator of fatty acid oxidation is the energy demand. Alterations in malonyl-CoA would not be the reason for, but rather the consequence of, the increased fatty acid oxidation at elevated workloads, when the level of acetyl-CoA decreases due to shifts in the kinetics of the Krebs cycle. This would make malonyl-CoA a feedback regulator that allows acyl-CoA entry into mitochondrial matrix space only when it is needed. Regulation of malonyl-CoA levels by AMPK does not seem to work as a master on–off switch, but rather as a modulator of fatty acid import. PMID:17008367

  2. Lightweight Regulated Power Supply

    NASA Technical Reports Server (NTRS)

    Mclyman, C. W.

    1985-01-01

    Power-supply circuit regulates output voltage by adjusting frequency of chopper circuit according to variations. Currently installed in battery charger for electric wheelchair, circuit is well suited to other uses in which light weight is important - for example, in portable computers, radios, and test instruments.

  3. Technical regulation in low-rise construction in the context of heat supply energy efficient projects

    NASA Astrophysics Data System (ADS)

    Prokofyeva, G. I.; Gusakova, N. V.

    2015-01-01

    The present article is devoted to the problem of energy saving and energy efficiency in construction industry and solving the issues of technical regulation and development of the sufficient regulatory basis. Economic calculations have been performed to study the influence of energy efficient heat sources and application of energy saving ventilation systems on the total operation costs. The efficiency of their use has been proved. The use of energy efficient heat sources and energy saving ventilation systems allowed significant reduction of utility expenses providing comfortable living conditions for the residents.

  4. Colostrum production in ewes: a review of regulation mechanisms and of energy supply.

    PubMed

    Banchero, G E; Milton, J T B; Lindsay, D R; Martin, G B; Quintans, G

    2015-05-01

    In sheep production systems based on extensive grazing, neonatal mortality often reaches 15% to 20% of lambs born, and the mortality rate can be doubled in the case of multiple births. An important contributing factor is the nutrition of the mother because it affects the amount of colostrum available at birth. Ewes carrying multiple lambs have higher energy requirements than ewes carrying a single lamb and this problem is compounded by limitations to voluntary feed intake as the gravid uterus compresses the rumen. This combination of factors means that the nutritional requirements of the ewe carrying multiple lambs can rarely be met by the supply of pasture alone. This problem can overcome by supplementation with energy during the last week of pregnancy, a treatment that increases colostrum production and also reduces colostrum viscosity, making it easier for the neonatal lamb to suck. In addition, litter size and nutrition both accelerate the decline in concentration of circulating progesterone that, in turn, triggers the onsets of both birth and lactogenesis, and thus ensures the synchrony of these two events. Furthermore, the presence of colostrum in the gut of the lamb increases its ability to recognize its mother, and thus improves mother-young bonding. Most cereal grains that are rich in energy in the form of starch, when used as supplements in late pregnancy will increase colostrum production by 90% to 185% above control (unsupplemented) values. Variation among types of cereal grain in the response they induce may be due to differences in the amount of starch digested post-ruminally. As a percentage of grain dry matter intake, the amount of starch entering the lower digestive tract is 14% for maize, 8.5% for barley and 2% for oats. Supplements of high quality protein from legumes and oleiferous seeds can also increase colostrum production but they are less effective than cereal grains. In conclusion, short-term supplementation before parturition

  5. Supply curves of conserved energy

    NASA Astrophysics Data System (ADS)

    Meier, A. K.

    1982-05-01

    Supply curves of conserved energy provide an accounting framework that expresses the potential for energy conservation. The economic worthiness of a conservation measure is expressed in terms of the cost of conserved energy, and a measure is considered economical when the cost of conserved energy is less than the price of the energy it replaces. A supply curve of conserved energy is independent of energy prices; however, the economical reserves of conserved energy will depend on energy prices. Double-counting of energy savings and error propagation are common problems when estimating conservation potentials, but supply curves minimize these difficulties and make their consequences predictable. The sensitivity of the cost of conserved energy is examined, as are variations in the optimal investment strategy in response to changes in inputs. Guidelines are presented for predicting the consequences of such changes.

  6. US energy consumption and supply

    NASA Astrophysics Data System (ADS)

    Vanatta, C. M.

    1981-01-01

    Energy consumption and cost in 1978 and 1979 are discussed with emphasis on the effect of imported oil on the economy of the United States. Some of the international aspects of energy supply are described, and actions to meet the probability of a cutoff of oil imports from the Persian Gulf area are suggested. Short and long range strategies for ensuring energy self sufficiency are discussed. A rationale for major, long range dependence on fission and fusion power is given, and the possible advantages of a nearly all electric energy system are mentioned. Projection of energy consumption and supply to the year 2020 based upon economic and demographic models is discussed.

  7. Supply Curves of Conserved Energy

    SciTech Connect

    Meier, Alan Kevin

    1982-05-01

    Supply curves of conserved energy provide an accounting framework that expresses the potential for energy conservation. The economic worthiness of a conservation measure is expressed in terms of the cost of conserved energy, and a measure is considered economical when the cost of conserved energy is less than the price of the energy it replaces. A supply curve of conserved energy is independent of energy prices; however, the economical reserves of conserved energy will depend on energy prices. Double-counting of energy savings and error propagation are common problems when estimating conservation potentials, but supply curves minimize these difficulties and make their consequences predictable. The sensitivity of the cost of conserved energy is examined, as are variations in the optimal investment strategy in response to changes in inputs. Guidelines are presented for predicting the consequences of such changes. The conservation supply curve concept can be applied to peak power, water, pollution, and other markets where consumers demand a service rather than a particular good.

  8. Post regulation circuit with energy storage

    DOEpatents

    Ball, Don G.; Birx, Daniel L.; Cook, Edward G.

    1992-01-01

    A charge regulation circuit provides regulation of an unregulated voltage supply and provides energy storage. The charge regulation circuit according to the present invention provides energy storage without unnecessary dissipation of energy through a resistor as in prior art approaches.

  9. A novel flattop current regulated energy discharge type pulsed power supply and magnet yielding 4. 4 kGauss-meter for 6 milliseconds

    SciTech Connect

    Visser, A.T.

    1989-07-01

    Most energy discharge power supplies obtain their bursts of power from the energy stored in charged capacitors when it is suddenly released into a load. This note describes the design of a similar small 800 Joules energy discharge type power supply and magnet. The magnet gap is 2 in.{times}2 in.{times}25-1/2 in. long and produces about 4.4 kGauss-meters at a rate of 12 pulses per minute. Each pulse is current regulated at the top for a duration of 6 msec. and varies less than 0.6% of set value. Current regulation at flattop is obtained by switching a resistor in and out of the discharge circuit with an IGBT at a rate of about 5 kHz. Most energy discharge systems produce half sine wave pulses, and current regulation is obtained by controlling the charge voltage at the energy storage capacitor, resulting only in a controlled peak current value of the half sine wave pulse. The current value at the top changes substantially during 6 msec. depending on the operating frequency.

  10. Power-supply regulation by microprocessor

    SciTech Connect

    Sheehan, J.; Langenbach, H.

    1983-01-01

    Many small-magnet power supplies are regulated by using a microprocessor system to generate control voltages to continuously servoregulate each power supply. The power supplies are of very simple design since all regulation and feedback hardware are parts of the microprocessor system. Most of the supplies are bipolar transistor followers, powered by a common unregulated dc power supply and are used to power trim steering magnets on the three NSLS synchrotron rings. Twelve-bit accuracy is obtained using commercially available microprocessor pc cards.

  11. Health costs of a reduced energy supply.

    PubMed

    McCarroll, J R

    1983-10-01

    Health effects associated with electricity production, especially air pollution from fossil fuel combustion, have received much attention in the past 30 years. Virtually no attention has been paid to the health costs of a reduced or overpriced energy supply although these are real and formidable. Stringent regulations mandating control technology on stack emissions and/or burning of low sulfur fuels have been promulgated which cost the American public billions of dollars. These have indeed alleviated some health problems, but pressures to further tighten regulations offer little chance of further health benefits commensurate with their cost and are most likely to produce a new series of problems.

  12. EU ENERGY STAR Certified Uninterruptible Power Supplies

    EPA Pesticide Factsheets

    Certified models meet all ENERGY STAR requirements as listed in the Version 1.0 ENERGY STAR Program Requirements for Uninterruptible Power Supplies that are effective as of August 1, 2012. A detailed listing of key efficiency criteria are available at http://www.energystar.gov/index.cfm?c=uninterruptible_power_supplies.pr_crit_uninterruptible_power_supplies

  13. ENERGY STAR Certified Uninterruptible Power Supplies

    EPA Pesticide Factsheets

    Certified models meet all ENERGY STAR requirements as listed in the Version 1.0 ENERGY STAR Program Requirements for Uninterruptible Power Supplies that are effective as of August 1, 2012. A detailed listing of key efficiency criteria are available at http://www.energystar.gov/index.cfm?c=uninterruptible_power_supplies.pr_crit_uninterruptible_power_supplies

  14. 76 FR 67721 - PNE Energy Supply, LLC;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission PNE Energy Supply, LLC; Supplemental Notice that Initial Market-Based Rate...-referenced proceeding of PNE Energy Supply, LLC's application for market-based rate authority, with...

  15. Water supply and demand in an energy supply model

    SciTech Connect

    Abbey, D; Loose, V

    1980-12-01

    This report describes a tool for water and energy-related policy analysis, the development of a water supply and demand sector in a linear programming model of energy supply in the United States. The model allows adjustments in the input mix and plant siting in response to water scarcity. Thus, on the demand side energy conversion facilities can substitute more costly dry cooling systems for conventional evaporative systems. On the supply side groundwater and water purchased from irrigators are available as more costly alternatives to unappropriated surface water. Water supply data is developed for 30 regions in 10 Western states. Preliminary results for a 1990 energy demand scenario suggest that, at this level of spatial analysis, water availability plays a minor role in plant siting. Future policy applications of the modeling system are discussed including the evaluation of alternative patterns of synthetic fuels development.

  16. Global Energy: Supply, Demand, Consequences, Opportunities

    ScienceCinema

    Majumdar, Arun

    2016-07-12

    July 29, 2008 Berkeley Lab lecture: Arun Majumdar, Director of the Environmental Energy Technologies Division, discusses current and future projections of economic growth, population, and global energy demand and supply, and explores the implications of these trends for the environment.

  17. Global Energy: Supply, Demand, Consequences, Opportunities

    SciTech Connect

    Majumdar, Arun

    2008-08-14

    July 29, 2008 Berkeley Lab lecture: Arun Majumdar, Director of the Environmental Energy Technologies Division, discusses current and future projections of economic growth, population, and global energy demand and supply, and explores the implications of these trends for the environment.

  18. Turkey's energy demand and supply

    SciTech Connect

    Balat, M.

    2009-07-01

    The aim of the present article is to investigate Turkey's energy demand and the contribution of domestic energy sources to energy consumption. Turkey, the 17th largest economy in the world, is an emerging country with a buoyant economy challenged by a growing demand for energy. Turkey's energy consumption has grown and will continue to grow along with its economy. Turkey's energy consumption is high, but its domestic primary energy sources are oil and natural gas reserves and their production is low. Total primary energy production met about 27% of the total primary energy demand in 2005. Oil has the biggest share in total primary energy consumption. Lignite has the biggest share in Turkey's primary energy production at 45%. Domestic production should be to be nearly doubled by 2010, mainly in coal (lignite), which, at present, accounts for almost half of the total energy production. The hydropower should also increase two-fold over the same period.

  19. Compact energy metabolism model: brain controlled energy supply.

    PubMed

    Göbel, Britta; Langemann, Dirk; Oltmanns, Kerstin M; Chung, Matthias

    2010-06-21

    The regulation of the energy metabolism is crucial to ensure the functionality of the entire organism. Deregulations may lead to severe pathologies such as obesity and type 2 diabetes mellitus. The decisive role of the brain as the active controller and heavy consumer in the complex whole body energy metabolism is the matter of recent research. Latest studies suggest that the brain's energy supply has the highest priority while all organs in the organism compete for the available energy resources. In our novel mathematical model, we address these new findings. We integrate energy fluxes and their control signals such as glucose fluxes, insulin signals as well as the ingestion momentum in our new dynamical system. As a novel characteristic, the hormone insulin is regarded as central feedback signal of the brain. Hereby, our model particularly contains the competition for energy between brain and body periphery. The analytical investigation of the presented dynamical system shows a stable long-term behavior of the entire energy metabolism while short time observations demonstrate the typical oscillating blood glucose variations as a consequence of food intake. Our simulation results demonstrate a realistic behavior even in situations like exercise or exhaustion, and key elements like the brain's preeminence are reflected. The presented dynamical system is a step towards a systemic understanding of the human energy metabolism and thus may shed light to defects causing diseases based on deregulations in the energy metabolism. Copyright 2010 Elsevier Ltd. All rights reserved.

  20. Energy supply problems for emergency telephones

    NASA Astrophysics Data System (ADS)

    Steiger, S.

    1983-09-01

    The energy supply for isolated emergency telephones is discussed. The required energy for telephoning is so low that dry batteries are used. An illumination was necessary to recognize and find these telephones. Besides reflecting foils, five energy supplies are used: cable connection to the public electric grid, dry batteries, rechargeable batteries, solar energy, and chemical sources. A solar generator (40W, 12V) was developed. Tests show that an 80W solar generator and 200 A/hr buffer batteries are required. The utilization of these generators could be endangered by theft.

  1. Biomass for energy: Supply prospects

    SciTech Connect

    Hall, D.O.; Rosillo-Calle, F.; Woods, J.; Williams, R.H.

    1993-12-31

    Biomass for energy can be obtained from residues of ongoing agricultural and forest-product industries, from harvesting forests, and from dedicated plantations. The harvesting of forests for biomass is likely to be limited by environmental concerns. Over the next couple of decades new bioenergy industries will be launched primarily using residues as feedstocks. Subsequently, the industrial base will shift to plantations, the largest potential source of biomass. The most promising sites for plantations are deforested and otherwise degraded lands in developing countries and excess croplands in the industrialized countries. Revenues from the sale of biomass crops grown on plantations established on degraded lands can help finance the restoration of these lands. Establishing plantations on excess croplands can be a new livelihood to farmers who might otherwise abandon their land because of foodcrop overproduction. In either case, biomass plantations can, with careful planning, substantially improve these lands ecologically relative to their present uses. But a substantial and sustained research and development effort is needed to ensure the realization and sustainability of high yields under a wide range of growing conditions. Moreover, the establishment and maintenance of biomass plantations must be carried out in the framework of sustainable economic development in ways that are acceptable and beneficial to the local people. Ultimately, land and water resource constraints will limit the contributions that biomass can make as an energy source in advanced societies. But biomass energy can nevertheless make major contributions to sustainable development before these limits are reached, if biomass is grown productively and sustainably and is efficiently converted to modern energy carriers that are used in energy-efficient end-use technologies. 88 refs., 5 figs., 13 tabs.

  2. Energy supply and demand in California

    NASA Technical Reports Server (NTRS)

    Griffith, E. D.

    1978-01-01

    The author expresses his views on future energy demand on the west coast of the United States and how that energy demand translates into demand for major fuels. He identifies the major uncertainties in determining what future demands may be. The major supply options that are available to meet projected demands and the policy implications that flow from these options are discussed.

  3. Coordinated regulation of nitrogen supply mode and initial cell density for energy storage compounds production with economized nitrogen utilization in a marine microalga Isochrysis zhangjiangensis.

    PubMed

    Chi, Lei; Yao, Changhong; Cao, Xupeng; Xue, Song

    2016-01-01

    Lipids and carbohydrates are main energy storage compounds (ESC) of microalgae under stressed conditions and they are potential feedstock for biofuel production. Yet, the sustainable and commercially successful production of ESC in microalgae needs to consider nitrogen utilization efficiency. Here the impact of different initial cell densities (ICDs) on ESC accumulation in Isochrysis zhangjiangensis under two nitrogen supply modes (an initially equal concentration of nitrogen per-cell in the medium (N1) and an equal total concentration of nitrogen in the culture system (N2)) were investigated. The results demonstrated that the highest ESC yield (1.36gL(-1)) at N1, which included a maximal nitrogen supply in the cultivation system, and the highest ESC content (66.5%) and ESC productivity per mass of nitrogen (3.28gg(-1) (N) day(-1)) at N2, were all obtained under a high ICD of 8.0×10(6)cellsmL(-1). Therefore I. zhangjiangensis qualifies for ESC-enriched biomass production with economized nitrogen utilization.

  4. Power Supplies for High Energy Particle Accelerators

    NASA Astrophysics Data System (ADS)

    Dey, Pranab Kumar

    2016-06-01

    The on-going research and the development projects with Large Hadron Collider at CERN, Geneva, Switzerland has generated enormous enthusiasm and interest amongst all to know about the ultimate findings on `God's Particle'. This paper has made an attempt to unfold the power supply requirements and the methodology adopted to provide the stringent demand of such high energy particle accelerators during the initial stages of the search for the ultimate particles. An attempt has also been made to highlight the present status on the requirement of power supplies in some high energy accelerators with a view that, precautionary measures can be drawn during design and development from earlier experience which will be of help for the proposed third generation synchrotron to be installed in India at a huge cost.

  5. DC switching regulated power supply for driving an inductive load

    DOEpatents

    Dyer, G.R.

    1983-11-29

    A dc switching regulated power supply for driving an inductive load is provided. The regulator basic circuit is a bridge arrangement of diodes and transistors. First and second opposite legs of the bridge are formed by first and second parallel-connected transistor arrays, respectively, while the third and fourth legs of the bridge are formed by appropriately connected first and second parallel connected diode arrays, respectively. A dc power supply is connected to the input of the bridge and the output is connected to the load. A servo controller is provided to control the switching rate of the transistors to maintain a desired current to the load. The regulator may be operated in three stages or modes: (1) for current runup in the load, both first and second transistor switch arrays are turned on and current is supplied to the load through both transistor arrays. (2) When load current reaches the desired level, the first switch is turned off, and load current flywheels through the second switch array and the fourth leg diode array connecting the second switch array in series with the load. Current is maintained by alternating between modes 1 and 2 at a suitable duty cycle and switching rate set by the controller. (3) Rapid current rundown is accomplished by turning both switch arrays off, allowing load current to be dumped back into the source through the third and fourth diode arrays connecting the source in series opposition with the load to recover energy from the inductive load.

  6. DC switching regulated power supply for driving an inductive load

    DOEpatents

    Dyer, George R.

    1986-01-01

    A power supply for driving an inductive load current from a dc power supply hrough a regulator circuit including a bridge arrangement of diodes and switching transistors controlled by a servo controller which regulates switching in response to the load current to maintain a selected load current. First and second opposite legs of the bridge are formed by first and second parallel-connected transistor arrays, respectively, while the third and fourth legs of the bridge are formed by appropriately connected first and second parallel connected diode arrays, respectively. The regulator may be operated in three "stages" or modes: (1) For current runup in the load, both first and second transistor switch arrays are turned "on" and current is supplied to the load through both transistor arrays. (2) When load current reaches the desired level, the first switch is turned "off", and load current "flywheels" through the second switch array and the fourth leg diode array connecting the second switch array in series with the load. Current is maintained by alternating between modes 1 and 2 at a suitable duty cycle and switching rate set by the controller. (3) Rapid current rundown is accomplished by turning both switch arrays "off", allowing load current to be dumped back into the source through the third and fourth diode arrays connecting the source in series opposition with the load to recover energy from the inductive load. The three operating states are controlled automatically by the controller.

  7. Regulation of Energy Balance.

    ERIC Educational Resources Information Center

    Bray, George A.

    1985-01-01

    Explains relationships between energy intake and expenditure focusing on the cellular, chemical and neural mechanisms involved in regulation of energy balance. Information is referenced specifically to conditions of obesity. (Physicians may earn continuing education credit by completing an appended test). (ML)

  8. Regulation of Energy Balance.

    ERIC Educational Resources Information Center

    Bray, George A.

    1985-01-01

    Explains relationships between energy intake and expenditure focusing on the cellular, chemical and neural mechanisms involved in regulation of energy balance. Information is referenced specifically to conditions of obesity. (Physicians may earn continuing education credit by completing an appended test). (ML)

  9. 141. NITROGEN SUPPLY PANEL PRESSURE REGULATOR IN NORTHWEST CORNER OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    141. NITROGEN SUPPLY PANEL PRESSURE REGULATOR IN NORTHWEST CORNER OF CONTROL ROOM (214), LSB (BLDG. 751), FACING WEST - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

  10. Energy supply chain optimization of hybrid feedstock processes: a review.

    PubMed

    Elia, Josephine A; Floudas, Christodoulos A

    2014-01-01

    The economic, environmental, and social performances of energy systems depend on their geographical locations and the surrounding market infrastructure for feedstocks and energy products. Strategic decisions to locate energy conversion facilities must take all upstream and downstream operations into account, prompting the development of supply chain modeling and optimization methods. This article reviews the contributions of energy supply chain studies that include heat, power, and liquid fuels production. Studies are categorized based on specific features of the mathematical model, highlighting those that address energy supply chain models with and without considerations of multiperiod decisions. Studies that incorporate uncertainties are discussed, and opportunities for future research developments are outlined.

  11. Global Energy: Supply, Demand, Consequences, Opportunities (LBNL Summer Lecture Series)

    SciTech Connect

    Majumdar, Arun

    2008-07-29

    Summer Lecture Series 2009: Arun Majumdar, Director of the Environmental Energy Technologies Division, discusses current and future projections of economic growth, population, and global energy demand and supply, and explores the implications of these trends for the environment.

  12. Global Energy: Supply, Demand, Consequences, Opportunities (LBNL Summer Lecture Series)

    ScienceCinema

    Majumdar, Arun

    2016-07-12

    Summer Lecture Series 2009: Arun Majumdar, Director of the Environmental Energy Technologies Division, discusses current and future projections of economic growth, population, and global energy demand and supply, and explores the implications of these trends for the environment.

  13. Assuring Supply Through New Energy Alternatives and Opportunities: The Defense Energy Support Center

    DTIC Science & Technology

    2009-04-27

    an energy and fuel supplier, DESC is sup- porting programs and initiatives that involve renewable energy , synthetic paraffinic kerosene, waste-to...overseeing their energy sustainment needs for the contract duration. BRANCHING INTO RENEWABLE ENERGY DESC recently developed the Renewable...projects intended to use renewable energy sources to supply power to installations. Solar Energy and Hydrogen The Defense Energy Supply Center has

  14. Energy supply alternatives for Picatinny Arsenal, NJ. Final report

    SciTech Connect

    Savoie, M.J.; Moshage, R.E.; Davidson, J.E.; Schanche, G.W.

    1992-09-01

    This report documents a study to determine the most economic methods of supplying thermal and electrical energy to Picatinny Arsenal, NJ. Based on energy use patterns and the condition of existing equipment, 10 major potential energy supply alternatives were identified and evaluated. Most of the alternatives contain additional options for various fuels and electrical generation. Each alternative was evaluated on the basis of (1) availability of funds, (2) initial capital costs, and (3) annual O and M costs.

  15. Multifunctional role of astrocytes as gatekeepers of neuronal energy supply

    PubMed Central

    Stobart, Jillian L.; Anderson, Christopher M.

    2013-01-01

    Dynamic adjustments to neuronal energy supply in response to synaptic activity are critical for neuronal function. Glial cells known as astrocytes have processes that ensheath most central synapses and express G-protein-coupled neurotransmitter receptors and transporters that respond to neuronal activity. Astrocytes also release substrates for neuronal oxidative phosphorylation and have processes that terminate on the surface of brain arterioles and can influence vascular smooth muscle tone and local blood flow. Membrane receptor or transporter-mediated effects of glutamate represent a convergence point of astrocyte influence on neuronal bioenergetics. Astrocytic glutamate uptake drives glycolysis and subsequent shuttling of lactate from astrocytes to neurons for oxidative metabolism. Astrocytes also convert synaptically reclaimed glutamate to glutamine, which is returned to neurons for glutamate salvage or oxidation. Finally, astrocytes store brain energy currency in the form of glycogen, which can be mobilized to produce lactate for neuronal oxidative phosphorylation in response to glutamatergic neurotransmission. These mechanisms couple synaptically driven astrocytic responses to glutamate with release of energy substrates back to neurons to match demand with supply. In addition, astrocytes directly influence the tone of penetrating brain arterioles in response to glutamatergic neurotransmission, coordinating dynamic regulation of local blood flow. We will describe the role of astrocytes in neurometabolic and neurovascular coupling in detail and discuss, in turn, how astrocyte dysfunction may contribute to neuronal bioenergetic deficit and neurodegeneration. Understanding the role of astrocytes as a hub for neurometabolic and neurovascular coupling mechanisms is a critical underpinning for therapeutic development in a broad range of neurodegenerative disorders characterized by chronic generalized brain ischemia and brain microvascular dysfunction. PMID:23596393

  16. Energy Supply and Development: A Major Concern.

    ERIC Educational Resources Information Center

    Avery, J. S.

    1978-01-01

    Reviews (1) problems created by United States dependence on foreign oil, (2) recent progress in oil and natural gas development in the U.S., and (3) alternative sources of energy such as the sun, coal, and uranium. (AV)

  17. Wind Energy: A Maturing Power Supply Possibility.

    ERIC Educational Resources Information Center

    Petersen, Erik Lundtang; And Others

    1987-01-01

    Suggests that wind energy for electrification will prove to be an appropriate technology with very positive socioeconomic benefits, especially in developing countries. Provides examples of projects conducted by a Danish wind research laboratory. (TW)

  18. Wind Energy: A Maturing Power Supply Possibility.

    ERIC Educational Resources Information Center

    Petersen, Erik Lundtang; And Others

    1987-01-01

    Suggests that wind energy for electrification will prove to be an appropriate technology with very positive socioeconomic benefits, especially in developing countries. Provides examples of projects conducted by a Danish wind research laboratory. (TW)

  19. Energy Supply and Development: A Major Concern.

    ERIC Educational Resources Information Center

    Avery, J. S.

    1978-01-01

    Reviews (1) problems created by United States dependence on foreign oil, (2) recent progress in oil and natural gas development in the U.S., and (3) alternative sources of energy such as the sun, coal, and uranium. (AV)

  20. Renewable energy and utility regulation

    SciTech Connect

    Not Available

    1991-04-10

    This report summarizes the results of a joint project on renewable energy of the National Association of Regulatory Utility Commissioners (NARUC) and the US DOE. NARUC`S Task Force on Renewable Energy conducted a review of the current state of renewable energy technologies to evaluate their potential and extract key policy lessons from experience already gained in deployment of these technologies in numerous states. The main focus of this effort has been to clarify how utility regulators affect the development of renewable energy resources. The goal of the project was twofold: (1) identify the factors that have led to success or failure or renewable energy technologies in various energy markets, and (2) to develop an agenda on renewable energy and utility regulation for NARUC and the DOE. This report consists of three sections: renewable energy contributions, costs and potential; factors affecting development of renewable energy resources; and a renewable energy agenda for NARUC.

  1. Renewable energy and utility regulation

    SciTech Connect

    Not Available

    1991-04-10

    This report summarizes the results of a joint project on renewable energy of the National Association of Regulatory Utility Commissioners (NARUC) and the US DOE. NARUC'S Task Force on Renewable Energy conducted a review of the current state of renewable energy technologies to evaluate their potential and extract key policy lessons from experience already gained in deployment of these technologies in numerous states. The main focus of this effort has been to clarify how utility regulators affect the development of renewable energy resources. The goal of the project was twofold: (1) identify the factors that have led to success or failure or renewable energy technologies in various energy markets, and (2) to develop an agenda on renewable energy and utility regulation for NARUC and the DOE. This report consists of three sections: renewable energy contributions, costs and potential; factors affecting development of renewable energy resources; and a renewable energy agenda for NARUC.

  2. Supply chain carbon footprinting and responsibility allocation under emission regulations.

    PubMed

    Chen, Jin-Xiao; Chen, Jian

    2017-03-01

    Reduction of greenhouse gas emissions has become an enormous challenge for any single enterprise and its supply chain because of the increasing concern on global warming. This paper investigates carbon footprinting and responsibility allocation for supply chains involved in joint production. Our study is conducted from the perspective of a social planner who aims to achieve social value optimization. The carbon footprinting model is based on operational activities rather than on firms because joint production blurs the organizational boundaries of footprints. A general model is proposed for responsibility allocation among firms who seek to maximize individual profits. This study looks into ways for the decentralized supply chain to achieve centralized optimality of social value under two emission regulations. Given a balanced allocation for the entire supply chain, we examine the necessity of over-allocation to certain firms under specific situations and find opportunities for the firms to avoid over-allocation. The comparison of the two regulations reveals that setting an emission standard per unit of product will motivate firms to follow the standard and improve their emission efficiencies. Hence, a more efficient and promising policy is needed in contrast to existing regulations on total production. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Optimizing energy for a 'green' vaccine supply chain.

    PubMed

    Lloyd, John; McCarney, Steve; Ouhichi, Ramzi; Lydon, Patrick; Zaffran, Michel

    2015-02-11

    This paper describes an approach piloted in the Kasserine region of Tunisia to increase the energy efficiency of the distribution of vaccines and temperature sensitive drugs. The objectives of an approach, known as the 'net zero energy' (NZE) supply chain were demonstrated within the first year of operation. The existing distribution system was modified to store vaccines and medicines in the same buildings and to transport them according to pre-scheduled and optimized delivery circuits. Electric utility vehicles, dedicated to the integrated delivery of vaccines and medicines, improved the regularity and reliability of the supply chains. Solar energy, linked to the electricity grid at regional and district stores, supplied over 100% of consumption meeting all energy needs for storage, cooling and transportation. Significant benefits to the quality and costs of distribution were demonstrated. Supply trips were scheduled, integrated and reliable, energy consumption was reduced, the recurrent cost of electricity was eliminated and the release of carbon to the atmosphere was reduced. Although the initial capital cost of scaling up implementation of NZE remain high today, commercial forecasts predict cost reduction for solar energy and electric vehicles that may permit a step-wise implementation over the next 7-10 years. Efficiency in the use of energy and in the deployment of transport is already a critical component of distribution logistics in both private and public sectors of industrialized countries. The NZE approach has an intensified rationale in countries where energy costs threaten the maintenance of public health services in areas of low population density. In these countries where the mobility of health personnel and timely arrival of supplies is at risk, NZE has the potential to reduce energy costs and release recurrent budget to other needs of service delivery while also improving the supply chain. Copyright © 2014 The Authors. Published by Elsevier Ltd

  4. Renewable energy water supply - Mexico program summary

    SciTech Connect

    Foster, R.

    1997-12-01

    This paper describes a program directed by the US Agency for International Development and Sandia National Laboratory which installed sustainable energy sources in the form of photovoltaic modules and wind energy systems in rural Mexico to pump water and provide solar distillation services. The paper describes the guidelines which appeared most responsible for success as: promote an integrated development program; install quality systems that develop confidence; instill local project ownership; train local industry and project developers; develop a local maintenance infrastructure; provide users training and operations guide; develop clear lines of responsibilities for system upkeep. The paper emphasizes the importance of training. It also presents much collected data as to the characteristics and performance of the installed systems.

  5. (Energy and electricity supply and demand)

    SciTech Connect

    Wilbanks, T.J.

    1990-10-09

    At the request of the International Atomic Energy Agency (IAEA), representing eleven international agencies which are sponsoring the 1991 Helsinki Symposium on Electricity and the Environment, I traveled to Brussels to participate in the second meeting of one of four advisory groups established to prepare for the Symposium. At the meeting, I was involved in a review of a draft issue paper being prepared for the Symposium and of the Symposium program.

  6. Optimizing energy for a ‘green’ vaccine supply chain

    PubMed Central

    Lloyd, John; McCarney, Steve; Ouhichi, Ramzi; Lydon, Patrick; Zaffran, Michel

    2015-01-01

    This paper describes an approach piloted in the Kasserine region of Tunisia to increase the energy efficiency of the distribution of vaccines and temperature sensitive drugs. The objectives of an approach, known as the ‘net zero energy’ (NZE) supply chain were demonstrated within the first year of operation. The existing distribution system was modified to store vaccines and medicines in the same buildings and to transport them according to pre-scheduled and optimized delivery circuits. Electric utility vehicles, dedicated to the integrated delivery of vaccines and medicines, improved the regularity and reliability of the supply chains. Solar energy, linked to the electricity grid at regional and district stores, supplied over 100% of consumption meeting all energy needs for storage, cooling and transportation. Significant benefits to the quality and costs of distribution were demonstrated. Supply trips were scheduled, integrated and reliable, energy consumption was reduced, the recurrent cost of electricity was eliminated and the release of carbon to the atmosphere was reduced. Although the initial capital cost of scaling up implementation of NZE remain high today, commercial forecasts predict cost reduction for solar energy and electric vehicles that may permit a step-wise implementation over the next 7–10 years. Efficiency in the use of energy and in the deployment of transport is already a critical component of distribution logistics in both private and public sectors of industrialized countries. The NZE approach has an intensified rationale in countries where energy costs threaten the maintenance of public health services in areas of low population density. In these countries where the mobility of health personnel and timely arrival of supplies is at risk, NZE has the potential to reduce energy costs and release recurrent budget to other needs of service delivery while also improving the supply chain. PMID:25444811

  7. A reduced energy supply strategy in active vibration control

    NASA Astrophysics Data System (ADS)

    Ichchou, M. N.; Loukil, T.; Bareille, O.; Chamberland, G.; Qiu, J.

    2011-12-01

    In this paper, a control strategy is presented and numerically tested. This strategy aims to achieve the potential performance of fully active systems with a reduced energy supply. These energy needs are expected to be comparable to the power demands of semi-active systems, while system performance is intended to be comparable to that of a fully active configuration. The underlying strategy is called 'global semi-active control'. This control approach results from an energy investigation based on management of the optimal control process. Energy management encompasses storage and convenient restitution. The proposed strategy monitors a given active law without any external energy supply by considering purely dissipative and energy-demanding phases. Such a control law is offered here along with an analysis of its properties. A suboptimal form, well adapted for practical implementation steps, is also given. Moreover, a number of numerical experiments are proposed in order to validate test findings.

  8. 76 FR 57897 - Energy Conservation Program: Energy Conservation Standards for Certain External Power Supplies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... mode energy efficiency standards established in paragraph (w)(1)(i) of this section shall not apply to... RIN 1904-AB57 Energy Conservation Program: Energy Conservation Standards for Certain External Power Supplies AGENCY: Office of Energy Efficiency and Renewable Energy, Department of Energy. ACTION: Final...

  9. The impact of food regulation on the food supply chain.

    PubMed

    Aruoma, Okezie I

    2006-04-03

    Food regulation in the main is aimed at protecting the consumer's health, increasing economic viability, harmonizing well-being and engendering fair trade on foods within and between nations. Consumers nowadays are faced with food or food ingredients that may derive from distant countries or continents, and with a less transparent food supply. Safety concerns must cover the range of different food chains relevant to a certain food product or product group, including all relevant producers, manufacturing sites and food service establishments within a country as well as those importing into the country. Hazard analysis at critical control points (HACCP), good manufacturing practice (GMP) and good hygiene practice (GHP) are major components of the safety management systems in the food supply chain. Principally, "a hazard" is a biological, chemical or physical agent in, or condition of, food that has the potential to cause an adverse health effect. The likelihood of occurrence and severity of the same is important for the assessment of the risk presented by the hazard to the food supply chain. The Government's regulatory mechanisms in accordance with the WTO agreements (HACCPs, sanitary and phytosanitary measures, etc.) oversee the analyses of public health problems and their association to the food supply. Under the WTO SPS Agreements and the codes of practices issued by the Codex Alimentarius Commission, there now exists a benchmark for international harmonization that guarantee the trade of safe food. Inevitably, food safety is still mainly the responsibility of the consumer.

  10. New Industrial Park Energy Supply (NIPES): a method of efficiently supplying energy to a community of industrial users

    SciTech Connect

    Not Available

    1984-08-01

    The New Industrial Park Energy Supply (NIPES) concept allows the use of coal by small as well as large industrial users. The NIPES concept consists of a system of Energy Supply Stations groups of cogeneration plants) and steam transmission lines that supplies process heat and electricity to multiple existing and/or new users in an industrial park(s) setting. The Energy Supply Stations grow along with the industrial park(s) as new industries are attracted by a reliable reasonably priced energy source. The growth of the Energy Supply Stations over a period of years allows the introduction of new energy sources and technologies as they become established. This report describes the generic NIPES concept and the results of the evaluation of a specific NIPES system for the Lake Charles, Louisiana, area. A ten-year process steam load growth scenario is developed including both new and existing industrial users. During the initial years of the growth scenario, process steam is supplied to the industrial users by several coal-fired plants. Later, as the process steam load develops, a two-unit nuclear plant is integrated into the specific NIPES system. An evaluation is also performed for a NIPES system consisting of all coal-fired plants. The specific NIPES system is compared to: (1) individual user owned oil-fired facilities for existing industrial users; and (2) individual user owned coal-fired facilities for new industrial plants. A financial analysis is performed to determine the total economic advantages associated with the NIPES system: savings in a steam costs for industrial users, potential return on investment for investors.

  11. Supply of and demand for selected energy related mineral commodities

    USGS Publications Warehouse

    Sibley, Scott F.

    2010-01-01

    In this report, subjects discussed include components of mineral supply, production, and consumption data, and information on selected mineral commodities in which the Energy Critical Elements Study Group has an interest, and U.S. Geological Survey (USGS) recycling studies, with some results of these studies.

  12. Summary report on the Department of Energy`s management and operating contractors` use of government supply sources

    SciTech Connect

    Not Available

    1994-08-19

    Since 1992, the Office of Inspector General (OIG) audited the use of Government supply sources by five Department of Energy management and operating (M&O) contractors. The Department of Energy Acquisition Regulation (DEAR) prescribes that M&O contractors should use Government supply sources to satisfy their requirements for goods and services when these sources are made available to them and when it is economically advantageous. Four of the five audits disclosed that M&O contractors did not always use Government supply sources when these sources were available at a lower cost to the Government. As a result, these contractors incurred costs of approximately $13.6 million more for the supplies and services than necessary. The audit reports addressing these issues are summarized. Management did not agree with all aspects of the audit findings. It raised several objections which, when analyzed, questioned the very basis for the Federal Supply Schedule Program and its application to the Department`s contractors. These included: (1) questions about the Regulation language establishing the Federal Supply Schedule Program, (2) the impacts the Federal Supply Schedule Program had on the ability of the M&O`s to meet their small and small disadvantaged business procurement targets, and (3) the cost effectiveness of the Federal Supply Schedule Program itself. In addition to management`s objections to several of the audit findings, the authors noted that the re-invention concepts embodied in the National Performance Review (NPR) appear not to support the policy of centralized procurement. The purpose of this report is to highlight unresolved issues so that policies related to the use of Government supply sources can be clarified for use throughout the Department`s complex.

  13. Energy Supply Options for Modernizing Army Heating Systems

    DTIC Science & Technology

    1999-01-01

    sheet is to assist a base or command engineer screen for the economic viability of several energy supply options. To select the most life-cycle cost...Energy Screening Analysis Site General Data Notice to users: This sheet is to assist a base or command engineer screen for the economic viability of several...Screening Analysis Site General Data Notice to users: This sheet is to assist a base or command engineer screen for the economic viability of several

  14. Structural Optimization of an Energy Supply System from Economic Viewpoint

    NASA Astrophysics Data System (ADS)

    Gamou, Satoshi; Ito, Koichi; Yokoyama, Ryohei; Yoshida, Shu

    An optimal planning method of system structure is proposed to determine kinds, numbers and capacities of equipment for an energy supply system installed in commercial and public buildings from economic viewpoint. In this method, they are determined together with maximum contract demands of utilities such as electricity and natural gas so as to minimize the annual total cost in consideration of system's annual operational strategies corresponding to seasonal and hourly energy demand requirements. A numerical study is carried out for an office building with total floor area of 15000m2. Through the study, the following are clarified: (a) the optimal system structure for the office building; (b) the economic effects of the optimal system compared to other typical energy supply systems; (c) the influence on the optimal system structure of the future efficiency improvement and initial capital cost reduction of equipment.

  15. Demand-driven energy supply from stored biowaste for biomethanisation.

    PubMed

    Aichinger, Peter; Kuprian, Martin; Probst, Maraike; Insam, Heribert; Ebner, Christian

    2015-10-01

    Energy supply is a global hot topic. The social and political pressure forces a higher percentage of energy supplied by renewable resources. The production of renewable energy in form of biomethane can be increased by co-substrates such as municipal biowaste. However, a demand-driven energy production or its storage needs optimisation, the option to store the substrate with its inherent energy is investigated in this study. The calorific content of biowaste was found unchanged after 45 d of storage (19.9±0.19 kJ g(-1) total solids), and the methane yield obtained from stored biowaste was comparable to fresh biowaste or even higher (approx. 400 m(3) Mg(-1) volatile solids). Our results show that the storage supports the hydrolysis of the co-substrate via acidification and production of volatile fatty acids. The data indicate that storage of biowaste is an efficient way to produce bioenergy on demand. This could in strengthen the role of biomethane plants for electricity supply the future. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Performance of fuel cell for energy supply of passive house

    SciTech Connect

    Badea, G.; Felseghi, R. A. Mureşan, D.; Naghiu, G.; Răboacă, S. M.; Aşchilean, I.

    2015-12-23

    Hydrogen technology and passive house represent two concepts with a remarkable role for the efficiency and decarbonisation of energy systems in the residential buildings area. Through design and functionality, the passive house can make maximum use of all available energy resources. One of the solutions to supply energy of these types of buildings is the fuel cell, using this technology integrated into a system for generating electricity from renewable primary sources, which take the function of backup power (energy reserve) to cover peak load and meteorological intermittents. In this paper is presented the results of the case study that provide an analysis of the energy, environmental and financial performances regarding energy supply of passive house by power generation systems with fuel cell fed with electrolytic hydrogen produced by harnessing renewable energy sources available. Hybrid systems have been configured and operate in various conditions of use for five differentiated locations according to the main areas of solar irradiation from the Romanian map. Global performance of hybrid systems is directly influenced by the availability of renewable primary energy sources - particular geo-climatic characteristics of the building emplacement.

  17. Performance of fuel cell for energy supply of passive house

    NASA Astrophysics Data System (ADS)

    Badea, G.; Felseghi, R. A.; Rǎboacǎ, S. M.; Aşchilean, I.; Mureşan, D.; Naghiu, G.

    2015-12-01

    Hydrogen technology and passive house represent two concepts with a remarkable role for the efficiency and decarbonisation of energy systems in the residential buildings area. Through design and functionality, the passive house can make maximum use of all available energy resources. One of the solutions to supply energy of these types of buildings is the fuel cell, using this technology integrated into a system for generating electricity from renewable primary sources, which take the function of backup power (energy reserve) to cover peak load and meteorological intermittents. In this paper is presented the results of the case study that provide an analysis of the energy, environmental and financial performances regarding energy supply of passive house by power generation systems with fuel cell fed with electrolytic hydrogen produced by harnessing renewable energy sources available. Hybrid systems have been configured and operate in various conditions of use for five differentiated locations according to the main areas of solar irradiation from the Romanian map. Global performance of hybrid systems is directly influenced by the availability of renewable primary energy sources - particular geo-climatic characteristics of the building emplacement.

  18. Possibilities of energy recovery and integrated energy supply for foundries

    NASA Astrophysics Data System (ADS)

    Pautz, J.

    1980-08-01

    The energy utilization of foundries equipped with electric melting and arc furnaces was investigated. Systems were studied which optimize heat economy. Studies of the energy balance of arc furnaces with conventional refractory linings and with water cooled linings clearly demonstrate recovery possibilities as a function of the temperature of the waste heat. Domestic water heating, central heating, scrap drying and steam generator plant applications are proposed for the recovered heat. A considerable overall improvement in efficiency can be achieved.

  19. Energy regulation in young people.

    PubMed

    Dodd, Caroline J

    2007-09-01

    Obesity in young people is now realised as a worldwide crisis of epidemic proportion. The aetiology of this disease suggests a disruption in regulation of energy at the population level, leading to a positive energy balance and excess adiposity. The relative contribution of food intake and physical inactivity remains to be elucidated. Treatment interventions have aimed to create a deficit in energy balance through manipulation of physical activity, behavioural components or, to a lesser extent, dietary modification. Whether such intervention is maintained in the long-term is as yet unclear, however it seems a combination of therapies is optimal. Mindful of a mismatch between energy intake and expenditure, recent work has begun to examine the acute relationship between physical activity and food intake in children. Initial findings suggest a short-term delay in compensation through energy intake for exercise- induced energy expenditure. The overarching study of energy regulation in children and adolescents is clearly multifaceted in nature and variables to be assessed or manipulated require careful consideration. The collection of paediatric physical activity, energy expenditure and food intake data is a time-consuming process, fraught with potential sources of error. Investigators should consider the validity and reliability of these and other issues, alongside the logistics of any proposed study. Despite these areas of concern, recent advances in the field should provide exciting opportunities for future research in paediatric energy regulation on a variety of levels. Key pointsPhysical activity appears to be an effective intervention in paediatric weight-management, however future studies need to be extended over the longer-term employing consistent protocols to aid comparison.In the short-term, exercise-induced energy expenditure and subsequent energy intake do not appear to be tightly regulated in young people; this acute imbalance is similar to the 'loose

  20. Space colonies and energy supply to the earth

    NASA Technical Reports Server (NTRS)

    Oneill, G. K.

    1975-01-01

    It is pointed out that a space manufacturing facility may be economically more effective than alternative industries on the earth for the construction of products which are to be used in geosynchronous or higher orbits. The suggestion is made to construct solar power stations at a space colony and relocate them in geosynchronous orbit to supply energy to the earth. Attention is given to energy problems and approaches for solving them, taking into account environmental effects and economic factors. Economic aspects of space manufacturing are discussed in some detail.

  1. Histone supply regulates S phase timing and cell cycle progression

    PubMed Central

    Günesdogan, Ufuk; Jäckle, Herbert; Herzig, Alf

    2014-01-01

    Eukaryotes package DNA into nucleosomes that contain a core of histone proteins. During DNA replication, nucleosomes are disrupted and re-assembled with newly synthesized histones and DNA. Despite much progress, it is still unclear why higher eukaryotes contain multiple core histone genes, how chromatin assembly is controlled, and how these processes are coordinated with cell cycle progression. We used a histone null mutation of Drosophila melanogaster to show that histone supply levels, provided by a defined number of transgenic histone genes, regulate the length of S phase during the cell cycle. Lack of de novo histone supply not only extends S phase, but also causes a cell cycle arrest during G2 phase, and thus prevents cells from entering mitosis. Our results suggest a novel cell cycle surveillance mechanism that monitors nucleosome assembly without involving the DNA repair pathways and exerts its effect via suppression of CDC25 phosphatase String expression. DOI: http://dx.doi.org/10.7554/eLife.02443.001 PMID:25205668

  2. Microbial substrate preference dictated by energy demand rather than supply

    NASA Astrophysics Data System (ADS)

    Amenabar, Maximiliano J.; Shock, Everett L.; Roden, Eric E.; Peters, John W.; Boyd, Eric S.

    2017-08-01

    Growth substrates that maximize energy yield are widely thought to be utilized preferentially by microorganisms. However, observed distributions of microorganisms and their activities often deviate from predictions based solely on thermodynamic considerations of substrate energy supply. Here we present observations of the bioenergetics and growth yields of a metabolically flexible, thermophilic strain of the archaeon Acidianus when grown autotrophically on minimal medium with hydrogen (H2) or elemental sulfur (S°) as an electron donor, and S° or ferric iron (Fe3+) as an electron acceptor. Thermodynamic calculations indicate that S°/Fe3+ and H2/Fe3+ yield three- and fourfold more energy per mole of electrons transferred, respectively, than the H2/S° couple. However, biomass yields in Acidianus cultures provided with H2/S° were eightfold greater than when provided S°/Fe3+ or H2/Fe3+, indicating that the H2/S° redox couple is preferred. Indeed, cells provided with all three growth substrates (H2, Fe3+ and S°) grew preferentially by reduction of S° with H2. We conclude that substrate preference is dictated by differences in the energy demand of electron transfer reactions in Acidianus when grown with different substrates, rather than substrate energy supply.

  3. Survey on a cold-energy supply system using natural energy

    NASA Astrophysics Data System (ADS)

    1991-03-01

    This paper examines how unused cold energy sources are distributed and exist in the natural world and also evaluates the feasibility of the system to take out these cold energy sources by the use of solar energy, etc. and to supply them as cold energy to the surrounding area. Using a heat supply model building located at the dam-lake side, the system is outlined in the following three cases: dam-lake water and commercial electric power source system; dam-lake water and photovoltaic power generation system; and conventional energy system. These are viewed in terms of economy and effective energy utilization. When using a cold energy source below 10 C directly for the cold energy supply, a large effect is expected in terms of cost and energy. In a combination with the photovoltaic power generation, the problem is measured against snowfall, etc. The cold energy supply system which uses dam-lake water as a heat source of the heat pump has a large significance. A marked effect can be expected from a combination of an ice making heat pump and low temperature dam-lake water, in terms of effective energy utilization and cost reduction.

  4. Energy supplies and future engines for land, sea, and air.

    PubMed

    Wilson, David Gordon

    2012-06-01

    The years 2012 and beyond seem likely to record major changes in energy use and power generation. The Japanese tsunami has resulted in large countries either scaling back or abolishing the future use of nuclear energy. The discovery of what seems like vast amounts of economically deliverable natural gas has many forecasting a rapid switch from coal- to gas-fired generating plants. On the other hand, environmentalists have strong objections to the production of natural gas and of petroleum by hydraulic fracturing from shale, or by extraction of heavy oil. They believe that global warming from the use of fossil fuels is now established beyond question. There has been rapid progress in the development of alternative energy supplies, particularly from on-shore and off-shore wind. Progress toward a viable future energy mix has been slowed by a U.S. energy policy that seems to many to be driven by politics. The author will review the history of power and energy to put all of the above in context and will look at possible future developments. He will propose what he believes to be an idealized energy policy that could result in an optimum system that would be arrived at democratically.

  5. Energy and air emission effects of water supply.

    PubMed

    Stokes, Jennifer R; Horvath, Arpad

    2009-04-15

    Life-cycle air emission effects of supplying water are explored using a hybrid life-cycle assessment For the typically sized U.S. utility analyzed, recycled water is preferable to desalination and comparable to importation. Seawater desalination has an energy and air emission footprint that is 1.5-2.4 times larger than that of imported water. However, some desalination modes fare better; brackish groundwater is 53-66% as environmentally intensive as seawater desalination. The annual water needs (326 m3) of a typical Californian that is met with imported water requires 5.8 GJ of energy and creates 360 kg of CO2 equivalent emissions. With seawater desalination, energy use would increase to 14 GJ and 800 kg of CO2 equivalent emissions. Meeting the water demand of California with desalination would consume 52% of the state's electricity. Supply options were reassessed using alternative electricity mixes, including the average mix of the United States and several renewable sources. Desalination using solar thermal energy has lower greenhouse gas emissions than that of imported and recycled water (using California's electricity mix), but using the U.S. mix increases the environmental footprint by 1.5 times. A comparison with a more energy-intensive international scenario shows that CO2 equivalent emissions for desalination in Dubai are 1.6 times larger than in California. The methods, decision support tool (WEST), and results of this study should persuade decision makers to make informed water policy choices by including energy consumption and material use effects in the decision-making process.

  6. The Regulation of Energy Medicine

    NASA Astrophysics Data System (ADS)

    Kosovich, Judy; Esq

    This paper describes the laws and regulations that affect the practice of energy medicine. State law often has more impact on a health care practice than federal law, but federal law provides a common denominator among states. Device law is emphasized here because practitioners of energy medicine are more likely to use devices than drugs. For purposes of this paper, energy medicine is defined as practices that measure or benefit energy flow and overall energy in the body. This broad definition encompasses things as diverse as certain forms of exercise, measurement of meridian resistance, the use of electrical current or magnetic pulses to relieve pain, and the use of light, sound, scent, touch, position, or movement to stimulate the body's own electrical systems. What is of greatest importance in determining legal implications of a practice is whether there are any health-related claims. Two federal entities are pivotal. The Food and Drug Administration ("FDA") is authorized to protect health and safety and the Federal Trade Commission ("FTC") is authorized to protect consumers from false or misleading advertising. There are 5 things that FDA looks at: 1) intended use, 2) claims made in advertising and in labeling, 3) substantial equivalence to a predicate, 4) safety, and 5) effectiveness. A concern regarding any one of these can be the basis for denying clearance to market a device. The FTC looks at whether statements are true and substantiated and whether they might be misleading. The FTC often consults with the FDA on the interpretation of technical information.

  7. Supply of reactants for Redox bulk energy storage systems

    NASA Technical Reports Server (NTRS)

    Gahn, R. F.

    1978-01-01

    World resources, reserves, production, and costs of reactant materials, iron, chromium, titanium and bromine for proposed redox cell bulk energy storage systems are reviewed. Supplying required materials for multimegawatt hour systems appears to be feasible even at current production levels. Iron and chromium ores are the most abundant and lowest cost of four reactants. Chromium is not a domestic reserve, but redox system installations would represent a small fraction of U.S. imports. Vast quantities of bromine are available, but present production is low and therefore cost is high. Titanium is currently available at reasonable cost, with ample reserves available for the next fifty years.

  8. Medium-chain fatty acid nanoliposomes for easy energy supply.

    PubMed

    Liu, Wei; Liu, Wei-Lin; Liu, Cheng-Mei; Liu, Jian-Hua; Yang, Shui-Bing; Zheng, Hui-Juan; Lei, Han-Wu; Ruan, Roger; Li, Ti; Tu, Zong-Cai; Song, Xin-Yong

    2011-06-01

    Developing a nanoliposome delivery system for an easy energy supply of medium-chain fatty acids (MCFAs) to improve oral doses and bioavailability. Bangham's method and high-pressure microfluidization were used to prepare MCFA liposomes. The easy energy-supply property of MCFA nanoliposomes was estimated by the anti-fatigue experiments of mice including a weight-loaded swimming test and its corresponding parameters (serum urea nitrogen, blood lactic acid, and hepatic glycogen). For comparison, nanoliposomes without MCFAs and MCFAs not entrapped in nanoliposomes were used throughout. Compared with crude MCFA liposomes according to Bangham's method, the MCFA nanoliposomes made by high-pressure microfluidization exhibited great advantages in their characteristics, with a small average diameter (76.2 ± 34.7 nm), narrow size distribution (polydispersity index 0.207), high ζ-potential (-50.51 mV), great entrapment efficiency (70.5%) and drug loading (9.4%), and good stability. The high-dose group and the MCFA group (680 mg/kg) showed a longer weight-loaded swimming time (104 ± 29 min, P = 0.087, and 108 ± 11 min, P = 0.047, respectively) and significantly higher hepatic glycogen (16.40 ± 1.45 mg/g, P < 0.001 and 17.27 ± 2.13 mg/g, P < 0.001, respectively) than the control group (59 ± 11 min and 8.79 ± 2.76 mg/g, respectively). Moreover, serum urea nitrogen (891.5 ± 113.4 mg/L, P = 0.024, and 876.6 ± 70.8 mg/L, P = 0.015, respectively) and blood lactic acid (6.05 ± 1.40 mmol/L, P = 0.001, and 5.95 ± 1.27 mmol/L, P < 0.001, respectively) in the high-dose group and the group with an equivalent MCFA dose were significantly lower than those in the control group (1153.6 ± 102.5 mg/L and 12.53 ± 1.86 mmol/L, respectively). Similar to MCFAs, MCFA nanoliposomes prepared by high-pressure microfluidization showed a strong easy energy-supply property, which suggested that MCFA nanoliposomes could be a potential drug candidate for an easy energy supply. Copyright © 2011

  9. Development of a Pressure Regulator to Conserve Energy Emitting in LP Gas Pressure Regulator

    NASA Astrophysics Data System (ADS)

    Kurihara, Yosuke; Misawa, Keigo; Watanabe, Kajiro; Kobayashi, Kazuyuki

    The development of electronics devices yields circuits which operates with low power consumption. This paper is aimed at describing a novel power supply system to such the devices. The energy levels diverged by mechanical vibration, pressure drops by regulators, thermal diverged, are low in the mechanical field but high enough to operate the electronics devices above. Here we describe a novel energy collecting method from pressure regulators in which high pressure is regulated to constant low pressure. In the regulation, energy is diverged. The method converts gas flow to rotation by a pneumatic motor and generates electric power by a generator connected with the motor. An LP gas regulator under normal use in a house, diverges about 30W energy. The devices developed here collected about 9W energy which is enough high for operating electronics devices around LP gas including intelligent gas meter.

  10. Energy demand and supply in human skeletal muscle.

    PubMed

    Barclay, C J

    2017-03-12

    The energy required for muscle contraction is provided by the breakdown of ATP but the amount of ATP in muscles cells is sufficient to power only a short duration of contraction. Buffering of ATP by phosphocreatine, a reaction catalysed by creatine kinase, extends the duration of activity possible but sustained activity depends on continual regeneration of PCr. This is achieved using ATP generated by oxidative processes and, during intense activity, by anaerobic glycolysis. The rate of ATP breakdown ranges from 70 to 140 mM min(-1) during isometric contractions of various intensity to as much as 400 mM min(-1) during intense, dynamic activity. The maximum rate of oxidative energy supply in untrained people is ~50 mM min(-1) which, if the contraction duty cycle is 0.5 as is often the case in cyclic activity, is sufficient to match an ATP breakdown rate during contraction of 100 mM min(-1). During brief, intense activity the rate of ATP turnover can exceed the rates of PCr regeneration by combined oxidative and glycolytic energy supply, resulting in a net decrease in PCr concentration. Glycolysis has the capacity to produce between 30 and 50 mM of ATP so that, for example, anaerobic glycolysis could provide ATP at an average of 100 mM min(-1) over 30 s of exhausting activity. The creatine kinase reaction plays an important role not only in buffering ATP but also in communicating energy demand from sites of ATP breakdown to the mitochondria. In that role, creatine kinases acts to slow and attenuate the response of mitochondria to changes in energy demand.

  11. Transforming intermittent wind energy to a baseload power supply economically

    SciTech Connect

    Cavallo, A.J.

    1996-12-31

    Wind generated electricity can be transformed from an intermittent to a baseload power supply cost-effectively by taking advantage of the fundamental properties of wind and by the efficient utilization of compressed air energy storage (CAES) systems. A utility scale wind-CAES-transmission system can have a 95 percent capacity factor at a cost of delivered electricity that is about 15 percent greater than a conventional wind energy system with a 34 percent capacity factor. This approach has several compelling advantages. It is based on existing technology and makes best use of costly transmission lines. It produces electricity that is the technical equivalent of that from fossil fuel or nuclear power stations. It minimizes greenhouse gas and other fossil fuel pollution, and is an industrial scale system that could cover a significant fraction of total electrical demand in regions such as the US, Mexico, China or Europe.

  12. Problems of cosmic laser energy supply to users on Earth

    NASA Astrophysics Data System (ADS)

    Kuzyakov, Boris A.; Batenin, Vyatcheslav M.; Klimovskii, Ivan I.; Konev, Yuri B.

    1999-01-01

    The global cosmic systems may be used for solution of problems of the Earth supply with energy in the nearest future. Such system can involve several cosmic platforms on the polar or heliostationary orbits. The present paper deals with prospects for using 3 types of the high power IR lasers for the cosmic power systems. The first laser type is a laser optically pumped by thermal radiation; it uses an intermediate 'black body' radiator heated by solar radiation and offers substantial and important advantages. The second laser type is a CO2 laser with radio frequency pumping. We can use several 33 X 30000 W lasers in one module for approximately 1 MW cosmic laser system. The module of 320 X 320 m2 solar cells is needed for such laser system energy supply. The third laser type is a CO2 gas-dynamic laser. The numerical studies of carbon dioxide laser that is pumped by solar-thermal heating were made, and the output laser power approximately 1 MW was calculated. The parameters studies were conducted for this laser conception.

  13. 10 CFR 205.375 - Guidelines defining inadequate fuel or energy supply.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Guidelines defining inadequate fuel or energy supply. 205.375 Section 205.375 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Electric... Electric Power § 205.375 Guidelines defining inadequate fuel or energy supply. An inadequate utility...

  14. 10 CFR 205.375 - Guidelines defining inadequate fuel or energy supply.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Guidelines defining inadequate fuel or energy supply. 205.375 Section 205.375 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Electric... Electric Power § 205.375 Guidelines defining inadequate fuel or energy supply. An inadequate utility...

  15. 10 CFR 205.375 - Guidelines defining inadequate fuel or energy supply.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Guidelines defining inadequate fuel or energy supply. 205.375 Section 205.375 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Electric... Electric Power § 205.375 Guidelines defining inadequate fuel or energy supply. An inadequate utility...

  16. 10 CFR 205.375 - Guidelines defining inadequate fuel or energy supply.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Guidelines defining inadequate fuel or energy supply. 205.375 Section 205.375 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Electric... Electric Power § 205.375 Guidelines defining inadequate fuel or energy supply. An inadequate utility...

  17. 10 CFR 205.375 - Guidelines defining inadequate fuel or energy supply.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Guidelines defining inadequate fuel or energy supply. 205.375 Section 205.375 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Electric... Electric Power § 205.375 Guidelines defining inadequate fuel or energy supply. An inadequate utility...

  18. Wind Energy's New Role in Supplying the World's Energy: What Role Will Structural Health Monitoring Play?

    SciTech Connect

    Butterfield, S.; Sheng, S.; Oyague, F.

    2009-12-01

    Wind energy installations are leading all other forms of new energy installations in the United States and Europe. In Europe, large wind plants are supplying as much as 25% of Denmark's energy needs and 8% of the electric needs for Germany and Spain, who have more ambitious goals on the horizon. Although wind energy only produces about 2% of the current electricity demand in the United States, the U.S. Department of Energy, in collaboration with wind industry experts, has drafted a plan that would bring the U.S. installed wind capacity up to 20% of the nation's total electrical supply. To meet these expectations, wind energy must be extremely reliable. Structural health monitoring will play a critical role in making this goal successful.

  19. Glucagon regulation of energy metabolism.

    PubMed

    Heppner, Kristy M; Habegger, Kirk M; Day, Jonathan; Pfluger, Paul T; Perez-Tilve, Diego; Ward, Brian; Gelfanov, Vasily; Woods, Steve C; DiMarchi, Richard; Tschöp, Matthias

    2010-07-14

    Glucagon has long been known as a counter-regulatory hormone to insulin of fundamental importance to glucose homeostasis. Its prominent ability to stimulate glycogenolysis and gluconeogenesis, has historically cast this peptide as one hormone where the metabolic consequences of increasing blood glucose levels, especially in obesity, are viewed largely as being deleterious. This perspective may be changing in light of emerging data and reconsideration of historic studies, which suggest that glucagon has beneficial effects on body fat mass, food intake, and energy expenditure. In this review, we discuss the mechanisms of glucagon-mediated body weight regulation as well as possible novel therapeutic approaches in the treatment of obesity and glucose intolerance that may arise from these findings. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009. Published by Elsevier Inc.

  20. Net-Zero Energy Buildings: A Classification System Based on Renewable Energy Supply Options

    SciTech Connect

    Pless, S.; Torcellini, P.

    2010-06-01

    A net-zero energy building (NZEB) is a residential or commercial building with greatly reduced energy needs. In such a building, efficiency gains have been made such that the balance of energy needs can be supplied with renewable energy technologies. Past work has developed a common NZEB definition system, consisting of four well-documented definitions, to improve the understanding of what net-zero energy means. For this paper, we created a classification system for NZEBs based on the renewable sources a building uses.

  1. The emerging role of AMPK in the regulation of breathing and oxygen supply

    PubMed Central

    Evans, A. Mark; Mahmoud, Amira D.; Moral-Sanz, Javier; Hartmann, Sandy

    2016-01-01

    Regulation of breathing is critical to our capacity to accommodate deficits in oxygen availability and demand during, for example, sleep and ascent to altitude. It is generally accepted that a fall in arterial oxygen increases afferent discharge from the carotid bodies to the brainstem and thus delivers increased ventilatory drive, which restores oxygen supply and protects against hypoventilation and apnoea. However, the precise molecular mechanisms involved remain unclear. We recently identified as critical to this process the AMP-activated protein kinase (AMPK), which is key to the cell-autonomous regulation of metabolic homoeostasis. This observation is significant for many reasons, not least because recent studies suggest that the gene for the AMPK-α1 catalytic subunit has been subjected to natural selection in high-altitude populations. It would appear, therefore, that evolutionary pressures have led to AMPK being utilized to regulate oxygen delivery and thus energy supply to the body in the short, medium and longer term. Contrary to current consensus, however, our findings suggest that AMPK regulates ventilation at the level of the caudal brainstem, even when afferent input responses from the carotid body are normal. We therefore hypothesize that AMPK integrates local hypoxic stress at defined loci within the brainstem respiratory network with an index of peripheral hypoxic status, namely afferent chemosensory inputs. Allied to this, AMPK is critical to the control of hypoxic pulmonary vasoconstriction and thus ventilation–perfusion matching at the lungs and may also determine oxygen supply to the foetus by, for example, modulating utero-placental blood flow. PMID:27574022

  2. Possibilities of utilizing alternative energy sources for combined heat supply systems in the Baltic

    SciTech Connect

    Shipkovs, P.; Grislis, V.; Zebergs, V. )

    1991-01-01

    The problem of alternative energy sources is an issue of major importance for the Baltic republics because of the limited supply of conventional energy resources. One of the ways to solve this problem could be the introduction of combined heat supply systems (CHSS). The combined heat supply systems are such systems where various energy sources in different regimes are made use of to ensure the optimum temperature on residential and industrial premises. The influence of climatic conditions on the selection of heat supply systems has been studied at large. In the present paper the use of alternative energy sources (AES) in combined heat supply systems (CHSS) is described.

  3. Adoption and supply of a distributed energy technology

    NASA Astrophysics Data System (ADS)

    Strachan, Neil Douglas

    2000-12-01

    Technical and economic developments in distributed generation (DG) represent an opportunity for a radically different energy market paradigm, and potentially significant cuts in global carbon emissions. This thesis investigates DG along two interrelated themes: (1) Early adoption and supply of the DG technology of internal combustion (IC) engine cogeneration. (2) Private and social cost implications of DG for private investors and within an energy system. IC engine cogeneration of both power and heat has been a remarkable success in the Netherlands with over 5,000 installations and 1,500MWe of installed capacity by 1997. However, the technology has struggled in the UK with an installed capacity of 110Mwe, fulfilling only 10% of its large estimated potential. An investment simulation model of DG investments in the UK and Netherlands was used, together with analysis of site level data on all DG adoptions from 1985 through 1997. In the UK over 60% of the early installations were sized too small (<140kWe) to be economically attractive (suppliers made their money with maintenance contracts). In the Netherlands, most facilities were sized well above the economic size threshold of 100kWe (lower due to reduced operating and grid connection costs). Institutional players were key in improved sizing of DG. Aided by energy market and CO2 reduction regulatory policy, Dutch distributions utilities played a proactive role in DG. This involved joint ventures with engine cogen suppliers and users, offering improved electricity buy-back tariffs and lower connection costs. This has allowed flexible operation of distributed generation, especially in electricity sales to the grid. Larger units can be sized for on-site heat requirements with electricity export providing revenue and aiding in management of energy networks. A comparison of internal and external costs of three distributed and three centralized generation technologies over a range of heat to power ratios (HPR) was made

  4. Securing US energy supplies: the private sector as an instrument of public policy

    SciTech Connect

    Prast, W.G.

    1981-01-01

    Dr. Prast suggests that policy options that rely on private companies to help secure energy supplies need to consider the conflicts and tensions that exist between these companies and the public agencies, especially Federal agencies, that regulate their activities. The US still needs a combination of private initiative and public control, but the naive approach of the 1960s should be replaced with an atmosphere of continuous assessment to make sure the companies are meeting public policy goals. A new kind of private/public arrangement may be needed to deal with the large reserves on Federal lands. This will require redefining present Federal roles in energy production to focus on frontier technology and eliminate a duplication of effort. Dr. Prast feels that improvements can be made in the effectiveness of the Federal bureaucracy by profiting from past errors, but that efforts to disband DOE are premature until a relationship of cooperation and confidence develops between private companies and regulators. 64 references. (DCK)

  5. Modeling water supply for the energy sector. Final report

    SciTech Connect

    Buras, N.

    1982-02-01

    This report summarizes the initial phase of constructing the WATER-EPM (W-EPM) model, which is the Energy Policy Model (EPM) of the Lawrence Livermore Laboratory enlarged to include quantitative descriptions of water availabilities. A salient feature of W-EPM is its regionalized formulation, which identifies areas of potentially sharp competition between energy and nonenergy demands for limited water resources and which represents in some detail the constraining situation regarding energy-related activities. In an attempt to maintain the original structure of EPM, water supply functions are estimated on the basis of information available regarding the investment required to build storage facilities which would yield the next increment of flow available to users with a given reliability. A second important feature of the linkage of water and energy submodels in W-EPM is the estimation of a water transportation matrix (dollars per acre-foot per mile). A third feature of W-EPM is that it includes projections of nonenergy water uses, as a surrogate for water demand functions. A limited number of computer test runs made with W-EPM indicate that in the Lower Colorado, Upper Colorado, Great Basin, and Platte-Lower Missouri regions shortages of water may occur as early as the current decade. California, Rio Grande, Texas-Gulf, and Upper Missouri regions may experience water shortages before the end of this century. Early in the next century, the Great Lakes-Ohio, Upper Mississippi, Pacific Northwest, and Arkansas-Lower-Mississippi regions may develop water shortages. The Atlantic Region apparently has ample water, except for local areas, to satisfy projected demands well into the 21st century.

  6. Energy development scenarios and water demands and supplies: an overview

    USGS Publications Warehouse

    Kilpatrick, F.A.

    1977-01-01

    On the basis of average mean annual flows, ample water exists in the upper Missouri River basin for energy development. The lack of storage and diversion works upstream as well as State compacts preclude the ready use of this surplus water. These surplus flows are impounded in mainstream reservoirs on the Missouri downstream from coal mining areas but could be transported back at some expense for use in Wyoming and North Dakota. There are limited water supplies available for the development of coal and oil shale industries in the upper Colorado River Basin. Fortunately oil shale mining, retorting and reclamation do not require as much water as coal conversion; in-situ oil shale retorting would seem to be particularly desirable in the light of reduced water consumption. Existing patterns of energy production, transport, and conversion suggest that more of the coal to be mined out West is apt to be transmitted to existing load centers rather than converted to electricity or gas in the water-short West. Scenarios of development of the West 's fossil fuels may be overestimating the need for water since they have assumed that major conversion industries would develop in the West. Transport of coal to existing users will require all means of coal movement including unit trains, barges, and coal slurry pipelines. The latter is considered more desirable than the development of conversion industries in the West when overall water consumption is considered. (Woodard-USGS)

  7. Brain Regulation of Energy Metabolism.

    PubMed

    Roh, Eun; Kim, Min Seon

    2016-12-01

    In healthy individuals, energy intake is in balance with energy expenditure, which helps to maintain a normal body weight. The brain's inability to control energy homeostasis underlies the pathology of hyperphagia and obesity. The brain detects body energy excess and deficit by sensing the levels of circulating metabolic hormones and nutrients and by receiving metabolic information from the periphery via the autonomic nervous system. A specialized neuronal network coordinates energy intake behavior and the metabolic processes affecting energy expenditure. Here, we briefly review neuronal mechanisms by which our body maintains energy balance.

  8. Brain Regulation of Energy Metabolism

    PubMed Central

    2016-01-01

    In healthy individuals, energy intake is in balance with energy expenditure, which helps to maintain a normal body weight. The brain's inability to control energy homeostasis underlies the pathology of hyperphagia and obesity. The brain detects body energy excess and deficit by sensing the levels of circulating metabolic hormones and nutrients and by receiving metabolic information from the periphery via the autonomic nervous system. A specialized neuronal network coordinates energy intake behavior and the metabolic processes affecting energy expenditure. Here, we briefly review neuronal mechanisms by which our body maintains energy balance. PMID:28029023

  9. 77 FR 20019 - FirstEnergy Solutions Corp., Allegheny Energy Supply Company, LLC v. PJM Interconnection, L.L.C...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FirstEnergy Solutions Corp., Allegheny Energy Supply Company, LLC v. PJM... Practice and Procedure, 18 CFR 385.206 and 206(h), FirstEnergy Solutions Corp. (FirstEnergy Solutions)...

  10. 75 FR 56021 - Energy Conservation Standards for Battery Chargers and External Power Supplies: Public Meeting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-15

    ... of Standards Rulemaking for Battery Chargers and External Power Supplies A. Background B. Current.... Current Rulemaking Process Subsequent to the activities noted above, Congress enacted the Energy... external power supply as ``an external power supply circuit that is used to convert household...

  11. Solar Energy Economics Revisited: The Promise and Challenge of Orbiting Reflectors for World Energy Supply

    NASA Technical Reports Server (NTRS)

    Billman, Kenneth W.; Gilbreath, William P.; Bowen, Stuart W.

    1978-01-01

    A system of orbiting, large-area, low mass density reflector satellites which provide nearly continuous solar energy to a world-distributed set of conversion sites is examined under the criteria for any potential new energy system: technical feasibility, significant and renewable energy impact, economic feasibility and social/political acceptability. Although many technical issues need further study, reasonable advances in space technology appear sufficient to implement the system. The enhanced insolation is shown to greatly improve the economic competitiveness of solar-electric generation to circa 1995 fossil/nuclear alternatives. The system is shown to have the potential for supplying a significant fraction of future domestic and world energy needs. Finally, the environmental and social issues, including a means for financing such a large shift to a world solar energy dependence, is addressed.

  12. Solar Energy Economics Revisited: The Promise and Challenge of Orbiting Reflectors for World Energy Supply

    NASA Technical Reports Server (NTRS)

    Billman, Kenneth W.; Gilbreath, William P.; Bowen, Stuart W.

    1978-01-01

    A system of orbiting, large-area, low mass density reflector satellites which provide nearly continuous solar energy to a world-distributed set of conversion sites is examined under the criteria for any potential new energy system: technical feasibility, significant and renewable energy impact, economic feasibility and social/political acceptability. Although many technical issues need further study, reasonable advances in space technology appear sufficient to implement the system. The enhanced insolation is shown to greatly improve the economic competitiveness of solar-electric generation to circa 1995 fossil/nuclear alternatives. The system is shown to have the potential for supplying a significant fraction of future domestic and world energy needs. Finally, the environmental and social issues, including a means for financing such a large shift to a world solar energy dependence, is addressed.

  13. Circuit protects regulated power supply against overload current

    NASA Technical Reports Server (NTRS)

    Airth, H. B.

    1966-01-01

    Sensing circuit in which a tunnel diode controls a series regulator transistor protects a low voltage transistorized dc regulator from damage by excessive load currents. When a fault occurs, the faulty circuit is limited to a preset percentage of the current when limiting first occurs.

  14. A novel four-quadrant power supply for low-energy correction magnets

    NASA Astrophysics Data System (ADS)

    García-Gil, R.; Espí, J. M.; Voelker, F.; Dede, E. J.; Castelló, J.

    2003-09-01

    This paper describes an efficient power supply to feed low-energy correction magnets in particle accelerator applications, where a controlled current with trapezoidal profile and four-quadrant operation is needed. The selected design is based on an AC-DC matrix converter topology, which uses the Space Vector Modulation (SVM) technique to obtain a near unity power factor at the AC input and output DC current regulation. This topology allows performing high-frequency isolation, while four-quadrant operation is maintained, and reducing volume and weight as compared with the classical thyristor (SCR)-based technology. Control tasks are implemented on an all-digital control card: output current regulation is accomplished in a digital signal processor device and SVM is implemented in a Field-Programmable Gate-Array. Simulations and experimental results of a 1.2 kW prototype validate the design.

  15. Voltage Regulator Chip: Power Supplies on a Chip

    SciTech Connect

    2010-09-01

    ADEPT Project: CPES at Virginia Tech is finding ways to save real estate on a computer's motherboard that could be used for other critical functions. Every computer processor today contains a voltage regulator that automatically maintains a constant level of electricity entering the device. These regulators contain bulky components and take up about 30% of a computer's motherboard. CPES at Virginia Tech is developing a voltage regulator that uses semiconductors made of gallium nitride on silicon (GaN-on-Si) and high-frequency soft magnetic material. These materials are integrated on a small, 3D chip that can handle the same amount of power as traditional voltage regulators at 1/10 the size and with improved efficiency. The small size also frees up to 90% of the motherboard space occupied by current voltage regulators.

  16. Modeling sustainability in renewable energy supply chain systems

    NASA Astrophysics Data System (ADS)

    Xie, Fei

    This dissertation aims at modeling sustainability of renewable fuel supply chain systems against emerging challenges. In particular, the dissertation focuses on the biofuel supply chain system design, and manages to develop advanced modeling framework and corresponding solution methods in tackling challenges in sustaining biofuel supply chain systems. These challenges include: (1) to integrate "environmental thinking" into the long-term biofuel supply chain planning; (2) to adopt multimodal transportation to mitigate seasonality in biofuel supply chain operations; (3) to provide strategies in hedging against uncertainty from conversion technology; and (4) to develop methodologies in long-term sequential planning of the biofuel supply chain under uncertainties. All models are mixed integer programs, which also involves multi-objective programming method and two-stage/multistage stochastic programming methods. In particular for the long-term sequential planning under uncertainties, to reduce the computational challenges due to the exponential expansion of the scenario tree, I also developed efficient ND-Max method which is more efficient than CPLEX and Nested Decomposition method. Through result analysis of four independent studies, it is found that the proposed modeling frameworks can effectively improve the economic performance, enhance environmental benefits and reduce risks due to systems uncertainties for the biofuel supply chain systems.

  17. 78 FR 12750 - FirstEnergy Solutions Corp., Allegheny Energy Supply Company, LLC v. PJM Interconnection, L.L.C...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FirstEnergy Solutions Corp., Allegheny Energy Supply Company, LLC v. PJM... sections 206 and 306 of the Federal Power Act, 16 U.S.C. 824(e) and 825(e), FirstEnergy Solutions Corp....

  18. 77 FR 790 - FirstEnergy Solutions Corp., Allegheny Energy Supply Company, LLC v. PJM Interconnection, L.L.C...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-06

    ... 306 of the Federal Power Act, Rule 206 of the Federal Energy Regulatory Commission's (Commission... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission FirstEnergy Solutions Corp., Allegheny Energy Supply Company, LLC v. PJM...

  19. Association between shortage of energy supply and nuclear gene mutations leading to carcinomatous transformation.

    PubMed

    DU, Jianping

    2016-01-01

    Anaerobic bacteria use glycolysis, an oxygen-independent metabolic pathway, whereas energy metabolism in the evolved eukaryotic cell is performed via oxidative phosphorylation, with all eukaryotic cell activities depending upon high energy consumption. However, in cancer cells evolving from eukaryotic cells, the energy metabolism switches from oxidative phosphorylation to glycolysis. The shortage of energy supply induces cancer cells to acquire specific characteristics. Base pair renewal is the most energy-consuming process in the cell, and shortage of energy supply may lead to errors in this process; the more prominent the shortage in energy supply, the more errors are likely to occur in base pair renewal, resulting in gene mutations and expression of cancer cell characteristics. Thus, shortage of energy supply is associated with carcinomatous transformation.

  20. Single Stage High Voltage Power Supply for Ion Energies

    NASA Astrophysics Data System (ADS)

    Herty, F.; Franke, A.; Kiewe, B.

    2008-09-01

    The European Space Mission GOCE, the AlphaBus Platform and the new High Efficiency Multistage Plasma (HEMP) thruster for future telecom missions, have triggered the development of a Generic High Voltage Power Supply referred as "HVPS - Next Generation" at Astrium. Focusing to a generic approach a high voltage module has been designed as a core functional block. It can be manufactured for high voltage levels between a few hundreds Volts up to 2000 Volts at maximum power of 1.4kW per module. Higher power levels can be supported by connecting the necessary number of modules in parallel. The HVPS portfolio comprises different converter topologies which are optimised either for a fixed or a variable input/output voltage. The high voltage module can be used for all converter types [1]. This paper deals with a patented single stage variant, being optimised to deliver a constant output voltage with highest efficiency when supplied by a regulated power bus system. The presented converter topology is a derivation of a single-stage, phase-shift controlled full bridge. The bridge is used to generate an ac voltage which is stepped up by a high voltage transformer. At the high voltage output side, the ac voltage is converted to a dc voltage using a rectifier and filter stage. All high voltage components are accommodated in a separate high voltage assembly which is completely encapsulated using a space proven epoxy-based potting material. The bridge is operated in a way that the transformer current has an almost rectangular shape. This reduces I2R losses of the bridge and the HV transformer and permits the use of small filter capacitors and inductors, resulting in a very high power to mass ratio. According to the a.m. current shape, the presented converter is named 'Flattop converter'. Reduction of copper losses is further achieved by reduction of the proximity losses of the HV transformer secondary and primary windings. All power switches and high voltage rectifier diodes

  1. Supply and demand: sink regulation of sugar accumulation in sugarcane.

    PubMed

    McCormick, A J; Watt, D A; Cramer, M D

    2009-01-01

    Sugarcane (Saccharum spp. hybrids) accumulates sucrose to high concentrations and, as a result, has been the focus of extensive research into the biochemistry and physiology of sucrose accumulation. Despite this, the relationship between source leaf photosynthetic activity and sucrose accumulation in the culm sink is not well understood. The observations that photosynthetic activity declines during culm maturation in commercial cultivars and that high-sucrose-accumulating noble ancestral genotypes (Saccharum officinarum L.) photosynthesize at rates two-thirds of those of low-sucrose ancestors (Saccharum spontaneum L.) indicate that source-sink communication may play a pivotal role in determining sucrose yield. Although maturation of the culm results in a decreased demand for sucrose, recent evidence from partial leaf shading, defoliation, and transgenic studies indicates that sugarcane cultivars are capable of further increases in sugar content. Furthermore, sugarcane leaves appear to retain the capacity to increase the supply of assimilate to culm tissues under conditions of increased assimilate demand. The relationship between source and sink tissues in sugarcane should be viewed within a supply-demand paradigm; an often neglected conceptual approach in the study of this crop. Uncoupling of the signalling pathways that mediate negative feedback between source and sink tissues may result in improved leaf assimilation rates and, consequently, lead to increased sugarcane sucrose yields.

  2. Integrating renewable energy technologies in the electric supply industry: A risk management approach

    SciTech Connect

    Hoff, T.E.

    1997-07-01

    Regulatory and technical forces are causing electric utilities to move from a natural monopoly to a more competitive environment. Associated with this movement is an increasing concern about how to manage the risks associated with the electric supply business. One approach to managing risks is to purchase financial instruments such as options and futures contracts. Another approach is to own physical assets that have low risk attributes or characteristics. This research evaluates how investments in renewable energy technologies can mitigate risks in the electric supply industry. It identifies risks that are known to be of concern to utilities and other power producers. These risks include uncertainty in fuel prices, demand, environmental regulations, capital cost, supply, and market structure. The research then determines how investments in renewables can mitigate these risks. Methods are developed to calculate the value of renewables in terms of their attributes of fuel costs, environmental costs, lead-time, modularity, availability, initial capital costs, and investment reversibility. Examples illustrate how to apply the methods.

  3. 41 CFR 109-28.306 - Customer supply center (CSC) accounts and related controls.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Management Federal Property Management Regulations System (Continued) DEPARTMENT OF ENERGY PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 28-STORAGE AND DISTRIBUTION 28.3-Customer Supply Centers §...

  4. Regional growth and energy supply: Is there an energy security issue?

    SciTech Connect

    Roop, J.M.; Freund, K.A.; Godoy-Kain, P.; Gu, A.Y.; Johnson, A.K.; Paananen, O.H.; Woodruff, M.G.

    1996-12-01

    This study examines how the growth of the developing world might affect energy markets in the future. Based on recent growth trends, world energy demand could reasonably be expected to grow from about 350 Exajoules (EJ: 1.0E18=0.95 Quad) to nearly 1025 EJ by the year 2020, nearly 3x current consumption estimates. Introduction of more energy-efficient technologies could reduce this growth by about 17% to 830 EJ. But one cannot rely exclusively on current trends to forecast future energy demand. The growth of the developing world will interact with supply to affect prices, which in turn will mitigate the growth of demand, and growth rates of energy use will be much more modes. Under the Business as Usual scenario, energy demand will grow to 835 EJ by 2020, and this could be reduced a further 15% to 714 EJ through the adoption of more energy efficient technologies. Fuel prices based on model results are analyzed. Energy security implications of rapid growth in the developing world are considered and found to be of likely little significance.

  5. Renewable Energy Supply for Power Dominated, Energy Intense Production Processes - A Systematic Conversion Approach for the Anodizing Process

    NASA Astrophysics Data System (ADS)

    >D Stollenwerk, T Kuvarakul, I Kuperjans,

    2013-06-01

    European countries are highly dependent on energy imports. To lower this import dependency effectively, renewable energies will take a major role in future energy supply systems. To assist the national and inter-European efforts, extensive changes towards a renewable energy supply, especially on the company level, will be unavoidable. To conduct this conversion in the most effective way, the methodology developed in this paper can support the planning procedure. It is applied to the energy intense anodizing production process, where the electrical demand is the governing factor for the energy system layout. The differences between the classical system layout based on the current energy procurement and an approach with a detailed load-time-curve analysis, using process decomposition besides thermodynamic optimization, are discussed. The technical effects on the resulting energy systems are shown besides the resulting energy supply costs which will be determined by hourly discrete simulation.

  6. Regulation of geothermal energy development in Colorado

    SciTech Connect

    Coe, B.A.; Forman, N.A.

    1980-01-01

    The regulatory system is presented in a format to help guide geothermal energy development. State, local, and federal agencies, legislation, and regulations are presented. Information sources are listed. (MHR)

  7. New histone supply regulates replication fork speed and PCNA unloading

    PubMed Central

    Mejlvang, Jakob; Feng, Yunpeng; Alabert, Constance; Neelsen, Kai J.; Jasencakova, Zuzana; Zhao, Xiaobei; Lees, Michael; Sandelin, Albin; Pasero, Philippe; Lopes, Massimo

    2014-01-01

    Correct duplication of DNA sequence and its organization into chromatin is central to genome function and stability. However, it remains unclear how cells coordinate DNA synthesis with provision of new histones for chromatin assembly to ensure chromosomal stability. In this paper, we show that replication fork speed is dependent on new histone supply and efficient nucleosome assembly. Inhibition of canonical histone biosynthesis impaired replication fork progression and reduced nucleosome occupancy on newly synthesized DNA. Replication forks initially remained stable without activation of conventional checkpoints, although prolonged histone deficiency generated DNA damage. PCNA accumulated on newly synthesized DNA in cells lacking new histones, possibly to maintain opportunity for CAF-1 recruitment and nucleosome assembly. Consistent with this, in vitro and in vivo analysis showed that PCNA unloading is delayed in the absence of nucleosome assembly. We propose that coupling of fork speed and PCNA unloading to nucleosome assembly provides a simple mechanism to adjust DNA replication and maintain chromatin integrity during transient histone shortage. PMID:24379417

  8. Fundamental performance of novel power supply for HTS magnet using solar energy system

    NASA Astrophysics Data System (ADS)

    Chung, Yoon Do; Kim, Dae Wook; Jo, Hyun Chul; Yoon, Yong Soo; Kim, Hyun Ki; Ko, Tae Kuk

    2011-06-01

    A technical fusion is an important option to establish renewal development in the mutual fields. We have proposed a novel superconducting power supply that is combined with superconducting power supply and solar energy system. An eternal electric energy can be converted by solar energy system, which contains solar panel, photovoltaic (PV) controller and energy-storing battery, can be utilized in the utility power of superconducting power applications. The novel power supply could operate without external utility power to charge the HTS load magnet due to the solar energy. We can improve the operating efficiency and install it in remote locations where utility power is not available. In this paper, as a first step of this work, we showed the possibility of technical fusion between a superconducting power supply and a solar energy system.

  9. World Energy Supplies: The Present Use and Future Prospects.

    ERIC Educational Resources Information Center

    Harris, John; Osborne, Jonathan

    1978-01-01

    Presents Unit Nine Change and Chance of the Nuffield Advanced Physics, dealing with energy conservation, and a novel statistical approach to diffusion, thermal equilibrium and thermodynamics. Information about energy resources, alternative sources of energy, and energy-cost of materials are also presented. (HM)

  10. World Energy Supplies: The Present Use and Future Prospects.

    ERIC Educational Resources Information Center

    Harris, John; Osborne, Jonathan

    1978-01-01

    Presents Unit Nine Change and Chance of the Nuffield Advanced Physics, dealing with energy conservation, and a novel statistical approach to diffusion, thermal equilibrium and thermodynamics. Information about energy resources, alternative sources of energy, and energy-cost of materials are also presented. (HM)

  11. 75 FR 16957 - Energy Conservation Program: Test Procedures for Battery Chargers and External Power Supplies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ...The U.S. Department of Energy (DOE) proposes major revisions to its test procedures for battery chargers and external power supplies. In particular, DOE proposes to insert a new active mode energy consumption test procedure for battery chargers, to assist in the development of energy conservation standards as directed by the Energy Independence and Security Act of 2007. DOE also proposes to......

  12. Opportunities for renewable energy technologies in water supply in developing country villages

    SciTech Connect

    Niewoehner, J.; Larson, R.; Azrag, E.; Hailu, T.; Horner, J.; VanArsdale, P.

    1997-03-01

    This report provides the National Renewable Energy Laboratory (NREL) with information on village water supply programs in developing countries. The information is intended to help NREL develop renewable energy technologies for water supply and treatment that can be implemented, operated, and maintained by villagers. The report is also useful to manufacturers and suppliers in the renewable energy community in that it describes a methodology for introducing technologies to rural villages in developing countries.

  13. Trends in the use of digital technology for control and regulation of power supplies.

    SciTech Connect

    Carwardine, J.; Lenkszus, F.

    1999-10-22

    Since the availability of computers, accelerator power supplies have relied on digital technology in some way, from such simple tasks as turning the supplies on and off to the supplying of computer-controlled references. However, advances in digital technology, both in performance and cost, allow considerably more than simple control and monitoring. This, coupled with increasing demand for higher performance and monitoring capabilities, has made it appealing to integrate such technology into power supply designs. This paper will review current trends in the use of such advanced technology as embedded DSP controllers, and the application of real-time algorithms to the regulation and control of power supplies for accelerators and other large-scale physics applications.

  14. A high voltage power supply for the AE-C and D low energy electron experiment

    NASA Technical Reports Server (NTRS)

    Gillis, J. A.

    1974-01-01

    A description is given of the electrical and mechanical design and operation of high voltage power supplies for space flight use. The supply was used to generate the spiraltron high voltage for low energy electron experiment on AE-C and D. Two versions of the supply were designed and built; one design is referred to as the low power version (AE-C) and the other as the high power version (AE-D). Performance is discussed under all operating conditions.

  15. An energy-efficient, adiabatic electrode stimulator with inductive energy recycling and feedback current regulation.

    PubMed

    Arfin, Scott K; Sarpeshkar, Rahul

    2012-02-01

    In this paper, we present a novel energy-efficient electrode stimulator. Our stimulator uses inductive storage and recycling of energy in a dynamic power supply. This supply drives an electrode in an adiabatic fashion such that energy consumption is minimized. It also utilizes a shunt current-sensor to monitor and regulate the current through the electrode via feedback, thus enabling flexible and safe stimulation. Since there are no explicit current sources or current limiters, wasteful energy dissipation across such elements is naturally avoided. The dynamic power supply allows efficient transfer of energy both to and from the electrode and is based on a DC-DC converter topology that we use in a bidirectional fashion in forward-buck or reverse-boost modes. In an exemplary electrode implementation intended for neural stimulation, we show how the stimulator combines the efficiency of voltage control and the safety and accuracy of current control in a single low-power integrated-circuit built in a standard .35 μm CMOS process. This stimulator achieves a 2x-3x reduction in energy consumption as compared to a conventional current-source-based stimulator operating from a fixed power supply. We perform a theoretical analysis of the energy efficiency that is in accord with experimental measurements. This theoretical analysis reveals that further improvements in energy efficiency may be achievable with better implementations in the future. Our electrode stimulator could be widely useful for neural, cardiac, retinal, cochlear, muscular and other biomedical implants where low power operation is important.

  16. [Energy and nutrient supply during childhood. VII. Vitamins. (author's transl)].

    PubMed

    Droese, W; Stolley, H; Kersting, M

    1980-06-01

    Vitamin intake (retinol, carotene, thiamine, riboflavin, niacin, ascorbic acid) of 2--14 year old children living at home is reported. The vitamin supply corresponds with the recommendations of the committees for nutrition of the Federal Republic of Germany, of the German Democratic Republic, of the United Kingdom and of USA. The vitamin intake of the children is in the same range with the vitamin intake of children in similar European countries. Children in USA get more vitamins with their diet. There are more foodstuffs with added vitamins in USA than in Europe. The children observed by us received with their warm midday meals 40--60% of their daily vitamin intake. Determinations of the mean vitamin intake for an individual child need longer observation periods (6--8 weeks) than determinations for other nutrients. With a mixed well-composed diet children have a good supply with vitamins.

  17. Factors Influencing Renewable Energy Production & Supply - A Global Analysis

    NASA Astrophysics Data System (ADS)

    Ali, Anika; Saqlawi, Juman Al

    2016-04-01

    Renewable energy is one of the key technologies through which the energy needs of the future can be met in a sustainable and carbon-neutral manner. Increasing the share of renewable energy in the total energy mix of each country is therefore a critical need. While different countries have approached this in different ways, there are some common aspects which influence the pace and effectiveness of renewable energy incorporation. This presentation looks at data and information from 34 selected countries, analyses the patterns, compares the different parameters and identifies the common factors which positively influence renewable energy incorporation. The most successful countries are analysed for their renewable energy performance against their GDP, policy/regulatory initiatives in the field of renewables, landmass, climatic conditions and population to identify the most influencing factors to bring about positive change in renewable energy share.

  18. The energy and emissions footprint of water supply for Southern California

    NASA Astrophysics Data System (ADS)

    Fang, A. J.; Newell, Joshua P.; Cousins, Joshua J.

    2015-11-01

    Due to climate change and ongoing drought, California and much of the American West face critical water supply challenges. California’s water supply infrastructure sprawls for thousands of miles, from the Colorado River to the Sacramento Delta. Bringing water to growing urban centers in Southern California is especially energy intensive, pushing local utilities to balance water security with factors such as the cost and carbon footprint of the various supply sources. To enhance water security, cities are expanding efforts to increase local water supply. But do these local sources have a smaller carbon footprint than imported sources? To answer this question and others related to the urban water-energy nexus, this study uses spatially explicit life cycle assessment to estimate the energy and emissions intensity of water supply for two utilities in Southern California: Los Angeles Department of Water and Power, which serves Los Angeles, and the Inland Empire Utility Agency, which serves the San Bernardino region. This study differs from previous research in two significant ways: (1) emissions factors are based not on regional averages but on the specific electric utility and generation sources supplying energy throughout transport, treatment, and distribution phases of the water supply chain; (2) upstream (non-combustion) emissions associated with the energy sources are included. This approach reveals that in case of water supply to Los Angeles, local recycled water has a higher carbon footprint than water imported from the Colorado River. In addition, by excluding upstream emissions, the carbon footprint of water supply is potentially underestimated by up to 30%. These results have wide-ranging implications for how carbon footprints are traditionally calculated at local and regional levels. Reducing the emissions intensity of local water supply hinges on transitioning the energy used to treat and distribute water away from fossil fuel, sources such as coal.

  19. Hormonal regulation of energy partitioning.

    PubMed

    Rohner-Jeanrenaud, F

    2000-06-01

    A loop system exists between hypothalamic neuropeptide Y (NPY) and peripheral adipose tissue leptin to maintain normal body homeostasis. When hypothalamic NPY levels are increased by fasting or by intracerebroventricular (i.c.v.) infusion, food intake and body weight increase. NPY has genuine hormono-metabolic effects. It increases insulin and corticosterone secretion relative to controls. These hormonal changes, acting singly or combined, favor adipose tissue lipogenic activity, while producing muscle insulin resistance. They also promote leptin release from adipose tissue. When infused i.c.v. to normal rats to mimic its central effects, leptin decreases NPY levels, thus food intake and body weight. Leptin i.c.v. has also genuine hormono-metabolic effects. It decreases insulinemia and adipose tissue storage ability, enhancing glucose disposal. Leptin increases the expression of uncoupling proteins (UCP-1, -2, -3) and thus energy dissipation. Leptin-induced changes favor oxidation at the expense of storage. Circadian fluctuations of NPY and leptin levels maintain normal body homeostasis. In animal obesity, defective hypothalamic leptin receptor activation prevent leptin from acting, with resulting obesity, insulin and leptin resistance.

  20. Impacts of the Resource Conservation and Recovery Act on energy supply

    NASA Astrophysics Data System (ADS)

    Carnes, S. A.; Copenhaver, E. D.; Weeter, D. W.; Calzonetti, F. J.; Tevepaugh, C. W.; Parzyck, D. C.

    1980-10-01

    The signficant characteristics of the waste streams of representative technologies of different energy supply alternatives are reported, including coal combustion and conversion, solar, geothermal, oil sands, oil shales, and petroleum refining. The overall relationship of RCRA and energy issues was examined, with special emphasis on how RCRA's hazardous waste provisions impact with these technologies. The issues addressed were: the magnitude of energy related waste; public and private sector responses to RCRA and energy waste problems; the relationship of RCRA to other environmental and public health protection policies; the effect of RCRA on the deployment of energy supply; the role of reuse, recovery, and utilization of energy waste; and possible health and environmental effects associated with solid or hazardous wastes of various energy supply systems.

  1. Assessment of Supply Chain Energy Efficiency Potentials: A U.S. Case Study

    SciTech Connect

    Masanet, Eric; Kramer, Klaas Jan; Homan, Gregory; Brown, Richard; Worrell, Ernst

    2009-01-01

    This paper summarizes a modeling framework that characterizes the key underlying technologies and processes that contribute to the supply chain energy use and greenhouse gas (GHG) emissions of a variety of goods and services purchased by U.S. consumers. The framework couples an input-output supply chain modeling approach with"bottom-up" fuel end use models for individual IO sectors. This fuel end use modeling detail allows energy and policy analysts to better understand the underlying technologies and processes contributing to the supply chain energy and GHG"footprints" of goods and services. To illustrate the policy-relevance of thisapproach, a case study was conducted to estimate achievable household GHG footprint reductions associated with the adoption of best practice energy-efficient supply chain technologies.

  2. NEMS International Energy Module, model documentation report: World Oil Market, Petroleum Products Supply and Oxygenates Supply components

    SciTech Connect

    Not Available

    1994-04-04

    The Energy Information Administration (EIA) is developing the National Energy Modeling System (NEMS) to enhance its energy forecasting capabilities and to provide the Department of Energy with a comprehensive framework for analyzing alternative energy` futures. NEMS is designed with a multi-level modular structure that represents specific energy supply activities, conversion processes, and demand sectors as a series of self-contained units which are linked by an integrating mechanism. The NEMS International Energy Module (IEM) computes world oil prices and the resulting patterns of international trade in crude oil and refined products. This report is a reference document for energy analysts, model users, and the public that is intended to meet EIA`s legal obligation to provide adequate documentation for all statistical and forecast reports (Public Law 93-275, section 57(b)(1). Its purpose is to describe the structure of the IEM. Actual operation of the model is not discussed here. The report contains four sections summarizing the overall structure of the IEM and its interface with other NEMS modules, mathematical specifications of behavioral relationships, and data sources and estimation methods. Following a general description of the function and rationale of its key components, system and equation level information sufficient to permit independent evaluation of the model`s technical details is presented.

  3. Programmable high voltage power supply with regulation confined to the high voltage section

    NASA Technical Reports Server (NTRS)

    Castell, Karen D. (Inventor); Ruitberg, Arthur P. (Inventor)

    1994-01-01

    A high voltage power supply in a dc-dc converter configuration includes a pre-regulator which filters and regulates the dc input and drives an oscillator which applies, in turn, a low voltage ac signal to the low side of a step-up high voltage transformer. The high voltage side of the transformer drives a voltage multiplier which provides a stepped up dc voltage to an output filter. The output voltage is sensed by a feedback network which then controls a regulator. Both the input and output of the regulator are on the high voltage side, avoiding isolation problems. The regulator furnishes a portion of the drive to the voltage multiplier, avoiding having a regulator in series with the load with its attendant, relatively high power losses. This power supply is highly regulated, has low power consumption, a low parts count and may be manufactured at low cost. The power supply has a programmability feature that allows for the selection of a large range of output voltages.

  4. High-fructose corn syrup, energy intake, and appetite regulation.

    PubMed

    Melanson, Kathleen J; Angelopoulos, Theodore J; Nguyen, Von; Zukley, Linda; Lowndes, Joshua; Rippe, James M

    2008-12-01

    High-fructose corn syrup (HFCS) has been implicated in excess weight gain through mechanisms seen in some acute feeding studies and by virtue of its abundance in the food supply during years of increasing obesity. Compared with pure glucose, fructose is thought to be associated with insufficient secretion of insulin and leptin and suppression of ghrelin. However, when HFCS is compared with sucrose, the more commonly consumed sweetener, such differences are not apparent, and appetite and energy intake do not differ in the short-term. Longer-term studies on connections between HFCS, potential mechanisms, and body weight have not been conducted. The main objective of this review was to examine collective data on associations between consumption of HFCS and energy balance, with particular focus on energy intake and its regulation.

  5. The effect of localized pulse-periodic energy supply on supersonic mixing in channels

    NASA Astrophysics Data System (ADS)

    Zheltovodov, A. A.; Pimonov, E. A.

    2017-08-01

    Results of numerical simulations of supersonic flows in flat channels with narrowing and expanding input sections confirm the possibility of intensification of the mixing of a low-density supersonic gas jet with surrounding co-current flow by means of a localized pulse-periodic energy supply. The influence of the positions of the jet and energy-supply source on the formation of large-scale vortex structures favoring the intensification of mixing is demonstrated.

  6. Nonstationary flow in a channel with variable cross section under conditions of periodic pulsed energy supply

    NASA Astrophysics Data System (ADS)

    Zamuraev, V. P.; Kalinina, A. P.

    2007-04-01

    The effect of a periodic pulsed supply of energy, equal to that of hydrogen combustion in air, on the structure of a supersonic flow in a channel of variable cross section modeling a ramjet tract has been studied. The flow has been numerically simulated based on two-dimensional gasdynamic equations. Various flow regimes are obtained depending on the configuration of energy supply zones and the excess air ratio in the channel.

  7. Local Energy Supply and Resiliency Act of 2013

    THOMAS, 113th Congress

    Sen. Franken, Al [D-MN

    2013-06-20

    06/25/2013 Committee on Energy and Natural Resources Subcommittee on Energy. Hearings held. With printed Hearing: S.Hrg. 113-70. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  8. Local Energy Supply and Resiliency Act of 2013

    THOMAS, 113th Congress

    Sen. Franken, Al [D-MN

    2013-06-20

    Senate - 06/25/2013 Committee on Energy and Natural Resources Subcommittee on Energy. Hearings held. With printed Hearing: S.Hrg. 113-70. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  9. Local Energy Supply and Resiliency Act of 2013

    THOMAS, 113th Congress

    Sen. Franken, Al [D-MN

    2013-06-20

    06/25/2013 Committee on Energy and Natural Resources Subcommittee on Energy. Hearings held. With printed Hearing: S.Hrg. 113-70. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  10. Sudden clearing of estuarine waters upon crossing the threshold from transport to supply regulation of sediment transport as an erodible sediment pool is depleted: San Francisco Bay, 1999

    USGS Publications Warehouse

    Schoellhamer, David H.

    2011-01-01

    The quantity of suspended sediment in an estuary is regulated either by transport, where energy or time needed to suspend sediment is limiting, or by supply, where the quantity of erodible sediment is limiting. This paper presents a hypothesis that suspended-sediment concentration (SSC) in estuaries can suddenly decrease when the threshold from transport to supply regulation is crossed as an erodible sediment pool is depleted. This study was motivated by a statistically significant 36% step decrease in SSC in San Francisco Bay from water years 1991–1998 to 1999–2007. A quantitative conceptual model of an estuary with an erodible sediment pool and transport or supply regulation of sediment transport is developed. Model results confirm that, if the regulation threshold was crossed in 1999, SSC would decrease rapidly after water year 1999 as observed. Estuaries with a similar history of a depositional sediment pulse followed by erosion may experience sudden clearing.

  11. Energy-conserving development regulations: current practice

    SciTech Connect

    Not Available

    1980-05-01

    Almost every aspect of land development has an effect on energy use, from minute architectural details to broad considerations of urban density. Energy-efficiency depends in part on how development is planned and carried out. Conventional development regulations, such as zoning ordinances and subdivision regulations, can be adapted in many ways to promote energy conservation at the community level. This report is about energy-efficient site and neighborhood design. It examines recent experiences of local governments that have adopted new development regulations or amended existing ones to promote energy conservation, more efficient generation and distribution, or a switch to alternative, renewable sources. Although much has been written in recent years about saving energy through community design, actual experience in applying these new ideas is still limited. To date, most communities have focused their efforts on studying the problem, documenting consumption patterns, and writing reports and plans. Only a handful have amended their land-use controls for the express purpose of saving energy. This study identifies 13 of these pioneering communities, after undertaking a survey of over 1400 local, regional, and state planning agencies. It takes a look at their experiences, to learn what has been done, how well it has worked, and what problems have been encountered.

  12. A study on an energy supply method for a transcutaneous energy transmission system.

    PubMed

    Ozeki, Toshinaga; Chinzei, Tsuneo; Abe, Yusuke; Saito, Itsuro; Isoyama, Takashi; Ono, Toshiya; Kouno, Akimasa; Ishimaru, Mitsuhiko; Takiura, Koki; Baba, Atsushi; Toyama, Takahiro; Imachi, Kou

    2003-01-01

    This study proposes a new type of a transcutaneous energy transmission system (TETS) that can supply electrical power for an implanted device without an external battery. In this system, the power is supplied from the floor to the shoes of the patients through coils that are set beneath the floor and the bottom of the shoes. If the patients wear the special shoes, they will be able to move freely on the specially designed floor without an external battery. Direct current (DC)-DC power efficiency was measured in the experiments, and the results showed that it varies with relative positions between the shoe and the floor coils. The results suggested that three-layered floor coils would enable the system to meet the demand for providing the required power anywhere on the floor without intermission. DC-DC power efficiency could be kept over 60% under the practical condition. It can then be concluded that the proposed system has a potential to provide better quality of life for the patients using a TETS.

  13. An overview of energy supply and demand in China

    SciTech Connect

    Liu, F.; Davis, W.B.; Levine, M.D.

    1992-05-01

    Although China is a poor country, with much of its population still farming for basic subsistence in rural villages, China is rich in energy resources. With the world`s largest hydropower potential, and ranking third behind the US and USSR in coal reserves, China is in a better position than many other developing countries when planning for its future energy development and self-sufficiency. China is now the third largest producer and consumer of commercial energy, but its huge populace dilutes this impressive aggregate performance into a per capita figure which is an order of magnitude below the rich industrialized nations. Despite this fact, it is still important to recognize that China`s energy system is still one of the largest in the world. A system this size allows risk taking and can capture economies of scale. The Chinese have maintained rapid growth in energy production for several decades. In order to continue and fully utilize its abundant resources however, China must successfully confront development challenges in many areas. For example, the geographic distribution of consumption centers poorly matches the distribution of resources, which makes transportation a vital but often weak link in the energy system. Another example -- capital -- is scarce relative to labor, causing obsolete and inefficiently installed technology to be operated well beyond what would be considered its useful life in the West. Major improvements in industrial processes, buildings, and other energy-using equipment and practices are necessary if China`s energy efficiency is to continue to improve. Chinese energy planners have been reluctant to invest in environmental quality at the expense of more tangible production quotas.

  14. An overview of energy supply and demand in China

    SciTech Connect

    Liu, F.; Davis, W.B.; Levine, M.D.

    1992-05-01

    Although China is a poor country, with much of its population still farming for basic subsistence in rural villages, China is rich in energy resources. With the world's largest hydropower potential, and ranking third behind the US and USSR in coal reserves, China is in a better position than many other developing countries when planning for its future energy development and self-sufficiency. China is now the third largest producer and consumer of commercial energy, but its huge populace dilutes this impressive aggregate performance into a per capita figure which is an order of magnitude below the rich industrialized nations. Despite this fact, it is still important to recognize that China's energy system is still one of the largest in the world. A system this size allows risk taking and can capture economies of scale. The Chinese have maintained rapid growth in energy production for several decades. In order to continue and fully utilize its abundant resources however, China must successfully confront development challenges in many areas. For example, the geographic distribution of consumption centers poorly matches the distribution of resources, which makes transportation a vital but often weak link in the energy system. Another example -- capital -- is scarce relative to labor, causing obsolete and inefficiently installed technology to be operated well beyond what would be considered its useful life in the West. Major improvements in industrial processes, buildings, and other energy-using equipment and practices are necessary if China's energy efficiency is to continue to improve. Chinese energy planners have been reluctant to invest in environmental quality at the expense of more tangible production quotas.

  15. Energy storage in remote area power supply (RAPS) systems

    NASA Astrophysics Data System (ADS)

    Moseley, Patrick T.

    Preliminary cost analyses indicate that hybrid RAPS systems are more economically attractive as a means to provide electricity to remote villages than are alternatives such as 24 h diesel generation. A hybrid remote area power supply (RAPS) system is being deployed to provide 24 h electricity to villages in the Amazon region of Peru. The RAPS system consists of modules designed to provide 150 kWh per day of utility grade ac electricity over a 24 h period. Each module contains a diesel generator, battery bank using heavy-duty 2 V VRLA gelled electrolyte batteries, a battery charger, a photovoltaic array and an inverter. Despite early difficulties, the system in the first village has now commenced operation and the promise of RAPS schemes as a means for providing sustainable remote electrification appears to be bright.

  16. Melanocortin-4 receptor–regulated energy homeostasis

    PubMed Central

    Krashes, Michael J; Lowell, Bradford B; Garfield, Alastair S

    2017-01-01

    The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components—two antagonistically acting ligands and two cognate receptors—this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation. Over the last decade the application of conditional genetic techniques has facilitated the neuroanatomical dissection of the melanocortinergic network and identified the specific neural substrates and circuits that underscore the regulation of feeding behavior, energy expenditure, glucose homeostasis and autonomic outflow. In this regard, the melanocortin-4 receptor is a critical coordinator of mammalian energy homeostasis and body weight. Drawing on recent advances in neuroscience and genetic technologies, we consider the structure and function of the melanocortin-4 receptor circuitry and its role in energy homeostasis. PMID:26814590

  17. Regulation as a tool for improving the management of water supply and sanitation companies.

    PubMed

    Lee, T

    2000-01-01

    The establishment of a strong independent regulator appears to be the most successful means to remedy the endemic poor management of water supply and sanitation services. This paper discusses why this is so and illustrates the argument with reference to recent experience in Chile.

  18. Atmospheric Emissions from Forest Biomass Residues to Energy Supply Chain: A Case Study in Portugal

    PubMed Central

    Rafael, Sandra; Tarelho, Luis; Monteiro, Alexandra; Monteiro, Tânia; Gonçalves, Catarina; Freitas, Sylvio; Lopes, Myriam

    2015-01-01

    Abstract During the past decades, pressures on global environment and energy security have led to an increasing demand on renewable energy sources and diversification of the world's energy supply. The Portuguese energy strategy considers the use of Forest Biomass Residues (FBR) to energy as being essential to accomplish the goals established in the National Energy Strategy for 2020. However, despite the advantages pointing to FBR to the energy supply chain, few studies have evaluated the potential impacts on air quality. In this context, a case study was selected to estimate the atmospheric emissions of the FBR to the energy supply chain in Portugal. Results revealed that production, harvesting, and energy conversion processes are the main culprits for the biomass energy supply chain emissions (with a contribution higher than 90%), while the transport processes have a minor importance for all the pollutants. Compared with the coal-fired plants, the FBR combustion produces lower greenhouses emissions, on a mass basis of fuel consumed; the same is true for NOX and SO2 emissions. PMID:26064039

  19. Atmospheric Emissions from Forest Biomass Residues to Energy Supply Chain: A Case Study in Portugal.

    PubMed

    Rafael, Sandra; Tarelho, Luis; Monteiro, Alexandra; Monteiro, Tânia; Gonçalves, Catarina; Freitas, Sylvio; Lopes, Myriam

    2015-06-01

    During the past decades, pressures on global environment and energy security have led to an increasing demand on renewable energy sources and diversification of the world's energy supply. The Portuguese energy strategy considers the use of Forest Biomass Residues (FBR) to energy as being essential to accomplish the goals established in the National Energy Strategy for 2020. However, despite the advantages pointing to FBR to the energy supply chain, few studies have evaluated the potential impacts on air quality. In this context, a case study was selected to estimate the atmospheric emissions of the FBR to the energy supply chain in Portugal. Results revealed that production, harvesting, and energy conversion processes are the main culprits for the biomass energy supply chain emissions (with a contribution higher than 90%), while the transport processes have a minor importance for all the pollutants. Compared with the coal-fired plants, the FBR combustion produces lower greenhouses emissions, on a mass basis of fuel consumed; the same is true for NOX and SO2 emissions.

  20. Sustainable energy development and water supply security in Kamojang Geothermal Field: The Energy-Water Nexus

    NASA Astrophysics Data System (ADS)

    Sofyan, Y.; Nishijima, J.; Fujimitsu, Y.

    2014-12-01

    The Kamojang Geothermal Field (KGF) is a typical vapor dominated hydrothermal system in West Java, Indonesia. This geothermal field is the oldest exploited geothermal field in Indonesia. From 1983 to 2005, more than 160 million tons of steam have been exploited from the KGF and more than 30 million tons of water were injected into the reservoir system. The injected water come from condensed water, local river and ground water. Sustainable production in the geothermal energy development is the ability of the production system applied to sustain the stable production level over long times and to manage the mass balance between production, injection and natural recharge in the geothermal reservoir during exploitation. Mass balance in the reservoir system can be monitored by using time lapse gravity monitoring. Mass variation of hydrodynamic in the reservoir of KGF from 1999 to 2005 is about -3.34 Mt/year while is about -3.78 Mt/year from 1999 to 2008. Another period between 2009 and 2010, mass variation decreased about -8.24 Mt. According to the history of production and injection, natural recharge to the KGF's reservoir is estimated at about 2.77 Mt/year from 1999 to 2005 and 2.75 Mt/year from 1999 to 2008. Between 2009 and 2010, KGF has a bigger mass deficiency rate throughout 200 MWe maintain production. Large amount of fresh water is needed for sustainable geothermal energy production, while the domestic water supply need is also increased. Natural recharge, about 50% of injected water, cooling system, drilling and other production activities in KGF spend large amounts of fresh water. Water consumption for local people around KGF is about 1.46 MT/year. The water volume around KGF of total runoff is the range between dry season 0.07 MT/month and rainy season 4.4 MT/month. The water demands for sustainable geothermal production of KGF and for local people's consumption will increase in the future. Integrated planning between the energy and water sectors in KGF

  1. Foreign Direct Investment and Energy Supply in the Middle East and North Africa: A Correlational Study

    NASA Astrophysics Data System (ADS)

    Elghali, Siddig

    Middle East and North Africa countries have been criticized for failing to utilize foreign direct investment energy resources efficiently. The changing of energy resources environment of the past decades with its growing emphasis on the importance of imminent energy supply challenges require strategists to consider different types of energy resources investment to improve energy supply. One type of energy investment will show effectiveness and efficiency in utilizing foreign direct investment in exposing RE, fossil fuels, natural gas, and reducing CO2 emissions. The purpose of this quantitative correlational study was to utilize foreign direct investment to predict total primary energy supply in the Middle East and North Africa region between 1971 and 2013. The study was conducted using a sample size of 43 years of energy supply resources and foreign direct investment from 1971 to 2013, which includes all of the years for which FDI is available. RE potential may equip Middle East and North Africa countries with sustainable and clean electricity for centuries to come, as non-renewable energy resources may not meet the demands globally and domestically or environmentally. As demands for fossil fuels grow, carbon emissions will increase. RE may be a better option of CO 2 emissions sequestration and will increase electricity to rural areas without government subsidies and complex decision-making policies. RE infrastructure will reduce water desalinization costs, cooling systems, and be useful in heating. Establishing concentrated solar power may be useful for the region cooperation, negotiations, and integration to share this energy. The alternative sought to fossil fuels was nuclear power. However, nuclear power depends on depleting, non-renewable uranium resources. The cost of uranium will increase if widely used and the presence of a nuclear plant in an unstable region is unsafe. Thus, renewable energy as a long-term option is efficient. A nonlinear regression

  2. [Control of supply and use of energy substrates in the encephalon].

    PubMed

    Schelp, A O; Burini, R C

    1995-09-01

    Although accounting for 2% of body weight, brain has one of the greatest metabolic rates compared with other organs and systems. The energy metabolic consum is expended mainly in the maintenance of ionic gradient, essential to neuronal activity. Brain receives energy substrates from circulation, with interference of blood brain barrier (BBB). Glucose is the main substrate and has a metabolic rate so high as 150 g/day (0.7 mM/G/min). At cellular level, metabolism of glucose seems to be controlled by phosphofructokynase. If the cellular level were high enough, manose and other products like fructose 1,6 biphosphate, pyruvate, lactate and acetate can be used in the place of glucose. Lactate, when oxyded, consums at least 21% of the cerebral needs of O2. In ischemia and inflammatory infections, brain tissue produces lactate instead of use it. Ketone bodies reduce cerebral needs of glucose; in view of the disturbances that occur in cerebral production of succinyl CoA and guanosine 3 phosphate (GTP), they must be considered as complementary substrate but not as an alternative one. Although they can be metabolized, there are no evidences that brain could produce energy from systemic free fatty acids, even when hypoglicemia is present. Ethanol and glycerol are considered only at experimental level. Brain uptake of aminoacids occur better for long chain aminoacids, specially valine. The aminoacids that are synthetised in the brain (aspartate, gluconate and alanine) show the lower absortion rates. All aminoacids should be oxided to CO2 and H2O. Even when glucose consum is reduced to 30%, aminoacid accounts for only 10% of the energetic expenditure of the brain. To maintain cerebral glucose and oxygen supply to the brain, blood flow must be at least 800 ml/min. The regulation of supply and consumption of energy substrate by the brain is changed in few situations. Among them, are included the oxidation of lactate immediately before milk diet early in development and

  3. Ca(2+)-regulated cyclic electron flow supplies ATP for nitrogen starvation-induced lipid biosynthesis in green alga.

    PubMed

    Chen, Hui; Hu, Jinlu; Qiao, Yaqin; Chen, Weixian; Rong, Junfeng; Zhang, Yunming; He, Chenliu; Wang, Qiang

    2015-10-09

    We previously showed that both the linear photosynthetic electron transportation rate and the respiration rate dropped significantly during N starvation-induced neutral lipid accumulation in an oil-producing microalga, Chlorella sorokiniana, and proposed a possible role for cyclic electron flow (CEF) in ATP supply. In this study, we further exploited this hypothesis in both Chlorella sorokiniana C3 and the model green alga Chlamydomonas. We found that both the rate of CEF around photosystem I and the activity of thylakoid membrane-located ATP synthetase increased significantly during N starvation to drive ATP production. Furthermore, we demonstrated that the Chlamydomonas mutant pgrl1, which is deficient in PGRL1-mediated CEF, accumulated less neutral lipids and had reduced rates of CEF under N starvation. Further analysis revealed that Ca(2+) signaling regulates N starvation-induced neutral lipid biosynthesis in Chlamydomonas by increasing calmodulin activity and boosting the expression of the calcium sensor protein that regulates Pgrl1-mediated CEF. Thus, Ca(2+)-regulated CEF supplies ATP for N starvation-induced lipid biosynthesis in green alga. The increased CEF may re-equilibrate the ATP/NADPH balance and recycle excess light energy in photosystems to prevent photooxidative damage, suggesting Ca(2+)-regulated CEF also played a key role in protecting and sustaining photosystems.

  4. Energy Crisis: Environmental Issue Exacerbates Power Supply Problem

    ERIC Educational Resources Information Center

    Boffey, Philip M.

    1970-01-01

    Analyzes problems of providing sufficient electrical power in terms of inefficiency of industry and of the conflict between need for power and need for environmental quality. Suggests ways of slowing the growth in demand, and indicates needed research into energy production. (EB)

  5. Energy Crisis: Environmental Issue Exacerbates Power Supply Problem

    ERIC Educational Resources Information Center

    Boffey, Philip M.

    1970-01-01

    Analyzes problems of providing sufficient electrical power in terms of inefficiency of industry and of the conflict between need for power and need for environmental quality. Suggests ways of slowing the growth in demand, and indicates needed research into energy production. (EB)

  6. Nonregenerative natural resources in a sustainable system of energy supply.

    PubMed

    Bradshaw, Alex M; Hamacher, Thomas

    2012-03-12

    Following the lead of the European Union in introducing binding measures to promote the use of regenerative energy forms, it is not unreasonable to assume that the global demand for combustible raw materials for energy generation will be reduced considerably in the second half of this century. This will not only have a favourable effect on the CO(2) concentration in the atmosphere, but will also help preserve fossil fuels-important as raw materials in the chemical industry-for future generations. Nevertheless, associated with the concomitant massive shift to regenerative energy forms, there will be a strong demand for other exhaustible raw materials, in particular metals, some of which are already regarded as scarce. After reviewing the debate on mineral depletion between "cornucopians" and "pessimists", we discuss the meaning of mineral "scarcity", particularly in the geochemical sense, and mineral "exhaustion". The expected drastic increase in demand for mineral resources caused by demographic and societal pressures, that is, due to the increase in in-use stock, is emphasised. Whilst not discussing the issue of "strong" versus "weak" sustainability in detail, we conclude that regenerative energy systems-like nearly all resource-consuming systems in our society-do not necessarily satisfy generally accepted sustainability criteria. In this regard, we discuss some current examples, namely, lithium and cobalt for batteries, rare earth-based permanent magnets for wind turbines, cadmium and tellurium for solar cells and copper for electrical power distribution.

  7. Astrocyte activation in working brain: energy supplied by minor substrates.

    PubMed

    Dienel, Gerald A; Cruz, Nancy F

    2006-01-01

    Glucose delivered to brain by the cerebral circulation is the major and obligatory fuel for all brain cells, and assays of functional activity in working brain routinely focus on glucose utilization. However, these assays do not take into account the contributions of minor substrates or endogenous fuel consumed by astrocytes during brain activation, and emerging evidence suggests that glycogen, acetate, and, perhaps, glutamate, are metabolized by working astrocytes in vivo to provide physiologically significant amounts of energy in addition to that derived from glucose. Rates of glycogenolysis during sensory stimulation of normal, conscious rats are high enough to support the notion that glycogen can contribute substantially to astrocytic glucose utilization during activation. Oxidative metabolism of glucose provides most of the ATP for cultured astrocytes, and a substantial contribution of respiration to astrocyte energetics is supported by recent in vivo studies. Astrocytes preferentially oxidize acetate taken up into brain from blood, and calculated local rates of acetate utilization in vivo are within the range of calculated rates of glucose oxidation in astrocytes. Glutamate may also serve as an energy source for activated astrocytes in vivo because astrocytes in tissue culture and in adult brain tissue readily oxidize glutamate. Taken together, contributions of minor metabolites derived from endogenous and exogenous sources add substantially to the energy obtained by astrocytes from blood-borne glucose. Because energy-generating reactions from minor substrates are not taken into account by routine assays of functional metabolism, they reflect a "hidden cost" of astrocyte work in vivo.

  8. Energy density, energy intake, and body weight regulation in adults.

    PubMed

    Karl, J Philip; Roberts, Susan B

    2014-11-01

    The role of dietary energy density (ED) in the regulation of energy intake (EI) is controversial. Methodologically, there is also debate about whether beverages should be included in dietary ED calculations. To address these issues, studies examining the effects of ED on EI or body weight in nonelderly adults were reviewed. Different approaches to calculating dietary ED do not appear to alter the direction of reported relations between ED and body weight. Evidence that lowering dietary ED reduces EI in short-term studies is convincing, but there are currently insufficient data to determine long-term effectiveness for weight loss. The review also identified key barriers to progress in understanding the role of ED in energy regulation, in particular the absence of a standard definition of ED, and the lack of data from multiple long-term clinical trials examining the effectiveness of low-ED diet recommendations for preventing both primary weight gain and weight regain in nonobese individuals. Long-term clinical trials designed to examine the impact of dietary ED on energy regulation, and including multiple ED calculation methods within the same study, are still needed to determine the importance of ED in the regulation of EI and body weight. © 2014 American Society for Nutrition.

  9. Critique of the mid-range energy forecasting, system oil and gas supply models

    SciTech Connect

    Patton, W.P.

    1980-10-01

    The Mid-Range Energy Forecasting System (MEFS) is a model used by the Department of Energy to forecast domestic production, consumption and price for conventional energy sources on a regional basis over a period of 5 to 15 years. Among the energy sources included in the model are oil, gas and other petroleum fuels, coal, uranium, and electricity. Final consumption of alternative energy sources is broken into end-use categories, such as residential, commercial and industrial uses. Regional prices for all energy sources are calculated by iteratively equating domestic supply and demand. The purpose of this paper is to assess the ability of the Oil and Gas Supply Submodels of MEFS to reliably and accurately project oil and gas supply curves, which are used in the integrating model, along with fuel demand curves to estimate market price. The reliability and accuracy of the oil and gas model cannot be judged by comparing its predictions against actual observations because those observations have not yet occurred. The reliability and reasonableness of the oil and gas supply model can be judged, however, by analyzing how well its assumptions and predictions correspond to accepted economic principles. This is the approach taken in this critique. The remainder of this paper describes the general structure of the oil and gas supply model and how it functions to project the quantity of oil and gas forthcoming at given prices in a particular year, then discusses the economic soundness of the model, and finally suggests model changes to improve its performance.

  10. Potential supply and cost of biomass from energy crops in the TVA region

    SciTech Connect

    Graham, R.L.; Downing, M.E.

    1995-04-01

    The economic and supply structures of energy crop markets have not been established. Establishing the likely price and supply of energy crop biomass in a region is a complex task because biomass is not an established commodity as are oil, natural gas, and coal. In this study, the cost and supply of short-rotation woody crop (SRWC) and switchgrass biomass for the Tennessee Valley Authority (TVA) region-a 276-county area that includes portions of 11 states in the southeastern United States - are projected. Projected prices and quantities of biomass are assumed to be a function of the amount and quality of crop and pasture land available in a region, expected energy crop yields and production costs on differing soils and land types, and the profit that could be obtained from current conventional crop production on these same lands. Results include the supply curves of SRWC and switchgrass biomass that are projected to be available from the entire region, the amount and location of crop and pasture land that would be used, and the conventional agricultural crops that would be displaced as a function of energy crop production. Finally, the results of sensitivity analysis on the projected cost and supply of energy crop biomass are shown. In particular, the separate impacts of varying energy crop production costs and yields, and interest rates are examined.

  11. Increased food energy supply as a major driver of the obesity epidemic: a global analysis

    PubMed Central

    Chow, Carson C; Hall, Kevin D; Umali, Elaine; Swinburn, Boyd A

    2015-01-01

    Abstract Objective We investigated associations between changes in national food energy supply and in average population body weight. Methods We collected data from 24 high-, 27 middle- and 18 low-income countries on the average measured body weight from global databases, national health and nutrition survey reports and peer-reviewed papers. Changes in average body weight were derived from study pairs that were at least four years apart (various years, 1971–2010). Selected study pairs were considered to be representative of an adolescent or adult population, at national or subnational scale. Food energy supply data were retrieved from the Food and Agriculture Organization of the United Nations food balance sheets. We estimated the population energy requirements at survey time points using Institute of Medicine equations. Finally, we estimated the change in energy intake that could theoretically account for the observed change in average body weight using an experimentally-validated model. Findings In 56 countries, an increase in food energy supply was associated with an increase in average body weight. In 45 countries, the increase in food energy supply was higher than the model-predicted increase in energy intake. The association between change in food energy supply and change in body weight was statistically significant overall and for high-income countries (P < 0.001). Conclusion The findings suggest that increases in food energy supply are sufficient to explain increases in average population body weight, especially in high-income countries. Policy efforts are needed to improve the healthiness of food systems and environments to reduce global obesity. PMID:26170502

  12. Increased food energy supply as a major driver of the obesity epidemic: a global analysis.

    PubMed

    Vandevijvere, Stefanie; Chow, Carson C; Hall, Kevin D; Umali, Elaine; Swinburn, Boyd A

    2015-07-01

    We investigated associations between changes in national food energy supply and in average population body weight. We collected data from 24 high-, 27 middle- and 18 low-income countries on the average measured body weight from global databases, national health and nutrition survey reports and peer-reviewed papers. Changes in average body weight were derived from study pairs that were at least four years apart (various years, 1971-2010). Selected study pairs were considered to be representative of an adolescent or adult population, at national or subnational scale. Food energy supply data were retrieved from the Food and Agriculture Organization of the United Nations food balance sheets. We estimated the population energy requirements at survey time points using Institute of Medicine equations. Finally, we estimated the change in energy intake that could theoretically account for the observed change in average body weight using an experimentally-validated model. In 56 countries, an increase in food energy supply was associated with an increase in average body weight. In 45 countries, the increase in food energy supply was higher than the model-predicted increase in energy intake. The association between change in food energy supply and change in body weight was statistically significant overall and for high-income countries (P < 0.001). The findings suggest that increases in food energy supply are sufficient to explain increases in average population body weight, especially in high-income countries. Policy efforts are needed to improve the healthiness of food systems and environments to reduce global obesity.

  13. Research on Load Energy Efficiency of DC Power Supply

    NASA Astrophysics Data System (ADS)

    Yue, Qing; Sun, Yiwei; Li, Ke; Li, Mengyu

    Traditional distribution network based on AC current has severely suffered from low efficiency in actual application, especially when an increasing numbers of home appliances are technically rely on DC current. In this paper, the energy efficiency of DC distribution system was analysed by means of comparison with traditional AC system. Firstly four types of typical appliances were discussed in terms of energy efficiency, which are the server, air conditioner, laptop computer and lighting. And then Models were further built up to perform the case study of three familiar situations in modern life, namely a typical living apartment, an office building and a data center. Finally, the power efficiencies of the three buildings were sorted up for comparison and analysis.

  14. Electric energy supply systems: description of available technologies

    SciTech Connect

    Eisenhauer, J.L.; Rogers, E.A.; King, J.C.; Stegen, G.E.; Dowis, W.J.

    1985-02-01

    When comparing coal transportation with electric transmission as a means of delivering electric power, it is desirable to compare entire energy systems rather than just the transportation/transmission components because the requirements of each option may affect the requirements of other energy system components. PNL's assessment consists of two parts. The first part, which is the subject of this document, is a detailed description of the technical, cost, resource and environmental characteristics of each system component and technologies available for these components. The second part is a computer-based model that PNL has developed to simulate construction and operation of alternative system configurations and to compare the performance of these systems under a variety of economic and technical conditions. This document consists of six chapters and two appendices. A more thorough description of coal-based electric energy systems is presented in the Introduction and Chapter 1. Each of the subsequent chapters describes technologies for five system components: Western coal resources (Chapter 2), coal transportation (Chapter 3), coal gasification and gas transmission (Chapter 4), and electric power transmission (Chapter 6).

  15. The place of hard coal in energy supply pattern of Turkey

    SciTech Connect

    Yilmaz, A.O.; Aydiner, K.

    2009-07-01

    Lignite and hard coal are the major sources of domestic energy sources of Turkey. Hard coal is produced at only one district in the country. Zonguldak Hard Coal Basin is the major power for development of the Turkish steel-making industry. It is the only hard coal basin in the country and it has, to date, supplied approximately 400 million tons of run-of-mine hard coal. This article investigates the potential of hard coal as an energy source and discusses the measures to activate the region for the future energy supply objectives of the country.

  16. Materials Flows Through Industry Tool to Track Supply Chain Energy Demand

    SciTech Connect

    Carpenter, Alberta; Mann, Margaret; Gelman, Rachel; Lewis, John; Benson, David; Cresko, Joe; Ma, Seungwook

    2014-10-01

    In evaluating next-generation materials and processes, the supply chain can have a large impact on the life cycle energy impacts. The Materials Flow through Industry (MFI) tool was developed for the Department of Energy's Advanced Manufacturing Office to be able to evaluate the energy impacts of the U.S. supply chain. The tool allows users to perform process comparisons, material substitutions, and grid modifications, and to see the effects of implementing sector efficiency potentials (Masanet, et al. 2009). This paper reviews the methodology of the tool and provides results around specific scenarios.

  17. Nonstationary flow in the model channel of a ramjet engine in pulse-periodic energy supply

    NASA Astrophysics Data System (ADS)

    Zamuraev, V. P.; Kalinina, A. P.

    2008-05-01

    A study has been made of the influence of the pulse-periodic supply of energy that is equal to the energy released in the combustion of hydrogen in air on the structure of supersonic flow in a channel of variable cross section, modeling the duct of a ramjet engine. The flow has been modeled on the basis of two-dimensional nonstationary gas-dynamic equations. Different flow regimes have been obtained depending on the configuration of the zones of energy supply and the excess-air coefficients.

  18. Evaluating opportunities to improve material and energy impacts in commodity supply chains

    DOE PAGES

    Hanes, Rebecca J.; Carpenter, Alberta

    2017-01-10

    When evaluated at the scale of individual processes, next-generation technologies may be more energy and emissions intensive than current technology. However, many advanced technologies have the potential to reduce material and energy consumption in upstream or downstream processing stages. In order to fully understand the benefits and consequences of technology deployment, next-generation technologies should be evaluated in context, as part of a supply chain. This work presents the Materials Flow through Industry (MFI) supply chain modeling tool. The MFI tool is a cradle-to-gate linear network model of the US industrial sector that can model a wide range of manufacturing scenarios,more » including changes in production technology and increases in industrial energy efficiency. The MFI tool was developed to perform supply chain scale analyses in order to quantify the impacts and benefits of next-generation technologies and materials at that scale. For the analysis presented in this paper, the MFI tool is utilized to explore a case study comparing three lightweight vehicle supply chains to the supply chain of a conventional, standard weight vehicle. Several of the lightweight vehicle supply chains are evaluated under manufacturing scenarios that include next-generation production technologies and next-generation materials. Results indicate that producing lightweight vehicles is more energy and emission intensive than producing the non-lightweight vehicle, but the fuel saved during vehicle use offsets this increase. In this case study, greater reductions in supply chain energy and emissions were achieved through the application of the next-generation technologies than from application of energy efficiency increases.« less

  19. Evaluating Opportunities to Improve Material and Energy Impacts in Commodity Supply Chains

    SciTech Connect

    Hanes, Rebecca J.; Carpenter, Alberta

    2017-01-01

    When evaluated at the scale of individual processes, next-generation technologies may be more energy and emissions intensive than current technology. However, many advanced technologies have the potential to reduce material and energy consumption in upstream or downstream processing stages. In order to fully understand the benefits and consequences of technology deployment, next-generation technologies should be evaluated in context, as part of a supply chain. This work presents the Materials Flow through Industry (MFI) supply chain modeling tool. The MFI tool is a cradle-to-gate linear network model of the US industrial sector that can model a wide range of manufacturing scenarios, including changes in production technology and increases in industrial energy efficiency. The MFI tool was developed to perform supply chain scale analyses in order to quantify the impacts and benefits of next-generation technologies and materials at that scale. For the analysis presented in this paper, the MFI tool is utilized to explore a case study comparing three lightweight vehicle supply chains to the supply chain of a conventional, standard weight vehicle. Several of the lightweight vehicle supply chains are evaluated under manufacturing scenarios that include next-generation production technologies and next-generation materials. Results indicate that producing lightweight vehicles is more energy and emission intensive than producing the non-lightweight vehicle, but the fuel saved during vehicle use offsets this increase. In this case study, greater reductions in supply chain energy and emissions were achieved through the application of the next-generation technologies than from application of energy efficiency increases.

  20. Public utility regulation and national energy policy

    SciTech Connect

    Navarro, P.

    1980-09-01

    The linkage between Public Utility Commission (PUC) regulation, the deteriorating financial health of the electric utility industry, and implementation of national energy policy, particularly the reduction of foreign petroleum consumption in the utility sector is examined. The role of the Nation's utilities in the pursuit of national energy policy goals and postulates a linkage between PUC regulation, the poor financial health of the utility industry, and the current and prospective failure to displace foreign petroleum in the utility sector is discussed. A brief history of PUC regulation is provided. The concept of regulatory climate and how the financial community has developed a system of ranking regulatory climate in the various State jurisdictions are explained. The existing evidence on the hypothesis that the cost of capital to a utility increases and its availability is reduced as regulatory climate grows more unfavorable from an investor's point of view is analyzed. The implications of this cost of capital effect on the electric utilities and collaterally on national energy policy and electric ratepayers are explained. Finally various State, regional and Federal regulatory responses to problems associated with PUC regulation are examined.

  1. Energy Supply- Production of Fuel from Agricultural and Animal Waste

    SciTech Connect

    Gabriel Miller

    2009-03-25

    The Society for Energy and Environmental Research (SEER) was funded in March 2004 by the Department of Energy, under grant DE-FG-36-04GO14268, to produce a study, and oversee construction and implementation, for the thermo-chemical production of fuel from agricultural and animal waste. The grant focuses on the Changing World Technologies (CWT) of West Hempstead, NY, thermal conversion process (TCP), which converts animal residues and industrial food processing biproducts into fuels, and as an additional product, fertilizers. A commercial plant was designed and built by CWT, partially using grant funds, in Carthage, Missouri, to process animal residues from a nearby turkey processing plant. The DOE sponsored program consisted of four tasks. These were: Task 1 Optimization of the CWT Plant in Carthage - This task focused on advancing and optimizing the process plant operated by CWT that converts organic waste to fuel and energy. Task 2 Characterize and Validate Fuels Produced by CWT - This task focused on testing of bio-derived hydrocarbon fuels from the Carthage plant in power generating equipment to determine the regulatory compliance of emissions and overall performance of the fuel. Task 3 Characterize Mixed Waste Streams - This task focused on studies performed at Princeton University to better characterize mixed waste incoming streams from animal and vegetable residues. Task 4 Fundamental Research in Waste Processing Technologies - This task focused on studies performed at the Massachusetts Institute of Technology (MIT) on the chemical reformation reaction of agricultural biomass compounds in a hydrothermal medium. Many of the challenges to optimize, improve and perfect the technology, equipment and processes in order to provide an economically viable means of creating sustainable energy were identified in the DOE Stage Gate Review, whose summary report was issued on July 30, 2004. This summary report appears herein as Appendix 1, and the findings of the report

  2. Placental supply of energy and protein substrates to the fetus.

    PubMed

    Hay, W W

    1994-12-01

    Table 1 shows an approximate metabolic balance sheet for the fetal sheep at late gestation. The metabolic balance in humans has not been determined but is estimated to be similar, except for a greater caloric requirement for fat deposition, adding about 33 kcal/kg/day to the total fetal caloric intake (34). The total fetal metabolic rate accounts for about 58% of caloric uptake. This percentage is close to the sum of the measured oxidation percentages of the principal energy substrates; this discrepancy cannot yet be explained.

  3. 10 CFR 603.1330 - Supplies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Supplies. 603.1330 Section 603.1330 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in this Part § 603.1330 Supplies. Tangible property other than real property and equipment. Supplies have...

  4. 77 FR 31182 - Final Withdrawal of Regulations Pertaining to Imports of Cotton Woven Fabric and Short Supply...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ... Pertaining to Imports of Cotton Woven Fabric and Short Supply Procedures AGENCY: Import Administration... (``IA'') issues this final rule withdrawing regulations pertaining to imports of cotton woven fabric and short supply procedures. Both sets of regulations are obsolete: The tariff quota on cotton woven...

  5. Evaluating the sustainability of an energy supply system using renewable energy sources: An energy demand assessment of South Carolina

    NASA Astrophysics Data System (ADS)

    Green, Cedric Fitzgerald

    Sustainable energy is defined as a dynamic harmony between the equitable availability of energy-intensive goods and services to all people and the preservation of the earth for future generations. Sustainable energy development continues to be a major focus within the government and regulatory governing bodies in the electric utility industry. This is as a result of continued demand for electricity and the impact of greenhouse gas emissions from electricity generating plants on the environment by way of the greenhouse effect. A culmination of increasing concerns about climate change, the nuclear incident in Fukushima four years ago, and discussions on energy security in a world with growing energy demand have led to a movement for increasing the share of power generation from renewable energy sources. This work studies demand for electricity from primarily residential, commercial, agricultural, and industrial customers in South Carolina (SC) and its effect on the environment from coal-fired electricity generating plants. Moreover, this work studies sustainable renewable energy source-options based on the renewable resources available in the state of SC, as viable options to supplement generation from coal-fired electricity generating plants. In addition, greenhouse gas emissions and other pollutants from primarily coal-fired plants will be defined and quantified. Fundamental renewable energy source options will be defined and quantified based on availability and sustainability of SC's natural resources. This work studies the environmental, economic, and technical aspects of each renewable energy source as a sustainable energy option to replace power generation from coal-fired plants. Additionally, social aspect implications will be incorporated into each of the three aspects listed above, as these aspects are explored during the research and analysis. Electricity demand data and alternative energy source-supply data in SC are carried out and are used to develop and

  6. The Effect of Natural Gas Supply on US Renewable Energy and Greenhouse Gas Emissions

    NASA Astrophysics Data System (ADS)

    Shearer, C.; Bistline, J.; Inman, M.; Davis, S. J.

    2014-12-01

    Increased use of natural gas has been promoted as a means of decarbonizing the US power sector, because of superior generator efficiency and lower CO2 emissions per unit of electricity than coal. We model the effect of different gas supplies on the US power sector and greenhouse gas (GHG) emissions. Across a range of climate policies, we find that more abundant natural gas decreases use of both coal and renewable energy technologies in the future. Without a climate policy, overall energy use also increases as the gas supply increases. With reduced deployment of lower-carbon renewable energies and increased electricity consumption, the effect of higher gas supplies on GHG emissions is small: cumulative emissions 2013-2055 in our high gas supply scenario are 2% less than in our low gas supply scenario, when there are no new climate policies and a methane leakage rate of 1.5% is assumed. Assuming leakage rates of 0 or 3% does not substantially alter this finding. In our results, only climate policies bring about a significant reduction in future CO2 emissions within the US electricity sector. Our results suggest that without strong limits on GHG emissions or policies that explicitly encourage renewable energy, more abundant natural gas may actually slow the process of decarbonization, primarily by delaying deployment of renewable energy technologies.

  7. Opportunities of energy supply of farm holdings on the basis of small-scale renewable energy sources

    NASA Astrophysics Data System (ADS)

    Efendiev, A. M.; Nikolaev, Yu. E.; Evstaf'ev, D. P.

    2016-02-01

    One of the major national economic problems of Russia is raising of agricultural production, which will provide strategic security and sustainable supply of the population with provisions. Creation of subsidiary small holdings, farm holdings, and peasant farm holdings will require addressing issues of energy supply. At considerable distance of small farms from centralized energy systems (by fuel, electricity and thermal energy) it is proposed to create a system of local energy networks on the basis of low-powered power plants using renewable energy sources (RES). There is economic unreasonableness of use of imported components of small power plants. Creation of new combined small power plants on renewable energy sources produced by domestic manufacturers is recommended. Schemes of arrangements of small power plants based on renewable energy sources are proposed, variants and characteristics of a basic source are provided—biogas plants developed by the authors. Calculations revealed that heat and power supply of self-contained farms distant from small power plants based on renewable energy sources is 2.5-2.6 times cheaper than from centralized networks. Production of biogas through anaerobic fermentation of organic waste of cattle complexes is considered as the basis. The analysis of biowaste output in various cattle farms is carried out, and the volume of biogas is determined to meet the requirements of these farms in electrical and thermal energy. The objective of the present article is to study the possibility of creating small combined power plants in Russia based on renewable sources of energy for independent consumers.

  8. Edible energy: balancing inputs and waste in food supply chain and biofuels from algae

    NASA Astrophysics Data System (ADS)

    Alimonti, Gianluca; Brambilla, Riccardo; Pileci, Rosaria; Romano, Riccardo; Rosa, Francesca; Spinicci, Luca

    2017-01-01

    Energy is life. Without it there is no water, there is no nutrition. Man's ability to live, grow, produce wealth is closely linked to the energy availability and use. Fire has been the first energy conversion technology; since that moment, the link between energy and progress has been indissoluble. Nowadays, a much greater energy input into the food supply chain has made a much higher food production possible. This might have an impact on the water availability. Algae are a promising solution for the energy-food-water nexus.

  9. Public utilities supply solar energy to eager customers

    SciTech Connect

    1995-01-01

    This articles examines how photovoltaic power is an alternative source of energy that can help utilities earn goodwill from their customers for being innovative, saving money, and reducing harmful emissions. Planners at municipal utilities are discovering the advantages that photovoltaic (PV) power offers. In addition to the thousands of private, federal, state, and commercial PV systems installed during the last 20 years, more than 65 cities in 24 states also have installed such systems. PV power is cost effective in selected utility applications today, and those applications are expanding every year. PV can be useful in applications ranging from low-power uses to decentralized applications to large, central stations. Public utilities in Austin and Sacramento are among those successfully using PV power for all three types of applications.

  10. [Structure problem analysis and trend prediction of energy supply and demand in Guangzhou City].

    PubMed

    Zhong, Xiao-qing; Ji, Xiu-jiang; Zhu, Hai-yan; Yi, Xia-jun; Ren, Fang

    2006-04-01

    This paper aims at the tense situation of energy demand and supply and analysis the current situation and problems of energy supply and demand in Guangzhou. We predict total demand of energy which will be 4534.7 x 10(4) of standard coal in 2010 by using the department analysis method and sequence method, and the balance between supply and demand of energy will be 45,000 thousand tons of standard coal. From the primary conclusions of our empirical analysis and together with the overall environment of energy in Guangdong and China, we think the development strategies of energy in Guangzhou in the future should involve several main points as following: (1) Energy of Guangzhou should base on the overall energy development programming of China and that is, it should depend on the "transmission of electricity from the western to the eastern region", power incorporation of Sanxia, power generated of water energy, nuclear power and new resource. (2) Stop setting up or expending the natural monopoly and resource oriented Huangpu thermal power plant located in the windward direction of summer of Guangzhou which has serious pollution and consumes large quantities of energy. (3) It should not absolutely depend on the coal of the poor mountainous region of Guangdong and small power station and can make full use of the resource potential.

  11. Glutamine transport. From energy supply to sensing and beyond.

    PubMed

    Scalise, Mariafrancesca; Pochini, Lorena; Galluccio, Michele; Indiveri, Cesare

    2016-08-01

    Glutamine is the most abundant amino acid in plasma and is actively involved in many biosynthetic and regulatory processes. It can be synthesized endogenously but becomes "conditionally essential" in physiological or pathological conditions of high proliferation rate. To accomplish its functions glutamine has to be absorbed and distributed in the whole body. This job is efficiently carried out by a network of membrane transporters that differ in transport mechanisms and energetics, belonging to families SLC1, 6, 7, 38, and possibly, 25. Some of the transporters are involved in glutamine traffic across different membranes for metabolic purposes; others are involved in specific signaling functions through mTOR. Structure/function relationships and regulatory aspects of glutamine transporters are still at infancy. In the while, insights in involvement of these transporters in cell redox control, cancer metabolism and drug interactions are arising, stimulating basic research to uncover molecular mechanisms of transport and regulation. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Regional industrial ecology: examples from regional economic systems of forest industry and energy supply in Finland.

    PubMed

    Korhonen, J

    2001-12-01

    Industrial ecology (IE) promotes the development of industrial systems based on recycling of matter and cascading of energy through cooperation. In this paper, the local/regional industrial ecosystem approach is reflected in two examples from Finland. The local forest industry system is based on renewable resources, waste materials and energy utilisation between forestry companies, a saw-mill, a pulp mill, a paper mill and a forest industry power plant. Waste energy from electricity production is used for production of heat and process steam. Regional city energy supply systems in Finland are also to a large extent arranged around power plants that utilise waste energy. The potential of combining the forest industry system with the energy supply systems of cities is considered and the conditions for success in the Finnish case are discussed.

  13. Reducing supply chain energy use in next-generation vehicle lightweighting

    SciTech Connect

    Hanes, Rebecca J.; Das, Sujit; Carpenter, Alberta

    2016-09-29

    Vehicle lightweighting reduces the amount of fuel consumed in a vehicle's use phase, but depending on what lightweight materials replace the conventional materials, and in what amounts, the manufacturing energy may increase or decrease. For carbon fiber reinforced polymer (CFRP), a next-generation lightweighting material, the increase in vehicle manufacturing energy is greater than the fuel savings, resulting in a net increase in energy consumption over a vehicle's manufacturing and use relative to a standard non-lightweighted car. [1] This work explores ways to reduce the supply chain energy of CFRP lightweighted vehicles through alternative production technologies and energy efficiency improvements. The objective is to determine if CFRP can offer energy savings comparable to or greater than aluminum, a conventional lightweighting material. Results of this analysis can be used to inform additional research and development efforts in CFRP production and future directions in lightweight vehicle production. The CFRP supply chain is modeled using the Material Flows through Industry (MFI) scenario modeling tool, which calculates 'mine to materials' energy consumption, material inventories and greenhouse gas emissions for industrial supply chains. In this analysis, the MFI tool is used to model the supply chains of two lightweighted vehicles, an aluminum intensive vehicle (AIV) and a carbon fiber intensive vehicle (CFV), under several manufacturing scenarios. Vehicle specifications are given in [1]. Scenarios investigated cover alternative carbon fiber (CF) feedstocks and energy efficiency improvements at various points in the vehicle supply chains. The alternative CF feedstocks are polyacrylonitrile, lignin and petroleum-derived mesophase pitch. Scenarios in which the energy efficiency of CF and CFRP production increases are explored using sector efficiency potential values, which quantify the reduction in energy consumption achievable when process equipment is

  14. Leaf habit and woodiness regulate different leaf economy traits at a given nutrient supply.

    PubMed

    Ordoñez, Jenny C; van Bodegom, Peter M; Witte, Jan-Philip M; Bartholomeus, Ruud P; van Dobben, Han F; Aerts, Rien

    2010-11-01

    The large variation in the relationships between environmental factors and plant traits observed in natural communities exemplifies the alternative solutions that plants have developed in response to the same environmental limitations. Qualitative attributes, such as growth form, woodiness, and leaf habit can be used to approximate these alternative solutions. Here, we quantified the extent to which these attributes affect leaf trait values at a given resource supply level, using measured plant traits from 105 different species (254 observations) distributed across 50 sites in mesic to wet plant communities in The Netherlands. For each site, soil total N, soil total P, and water supply estimates were obtained by field measurements and modeling. Effects of growth forms, woodiness, and leaf habit on relations between leaf traits (SLA, specific leaf area; LNC, leaf nitrogen concentration; and LPC, leaf phosphorus concentration) vs. nutrient and water supply were quantified using maximum-likelihood methods and Bonferroni post hoc tests. The qualitative attributes explained 8-23% of the variance within sites in leaf traits vs. soil fertility relationships, and therefore they can potentially be used to make better predictions of global patterns of leaf traits in relation to nutrient supply. However, at a given soil fertility, the strength of the effect of each qualitative attribute was not the same for all leaf traits. These differences may imply a differential regulation of the leaf economy traits at a given nutrient supply, in which SLA and LPC seem to be regulated in accordance to changes in plant size and architecture while LNC seems to be primarily regulated at the leaf level by factors related to leaf longevity.

  15. The feedback control cycle as regulator of past and future mineral supply

    NASA Astrophysics Data System (ADS)

    Wellmer, Friedrich-W.; Dalheimer, Manfred

    2012-10-01

    Mineral supply is controlled by a feedback mechanism. When there is a shortage of a commodity in a market economy, prices will rise, triggering this mechanism. The expectation of high financial returns will encourage inventiveness and creativity in the quest for new solutions. On the supply side, for primary resources, the appropriate response is to cut losses in the mining process, to lower the cut-off grade, to improve recoveries in the beneficiation and smelting processes, to expand existing production facilities, and to discover and bring into production new deposits. For secondary resources, the key to increasing the supply lies in improving recycling rates by better technology, reprocessing lower-grade scrap which becomes economic because of increased prices, and reducing downgrading to optimize the usefulness of secondary materials. On the demand side, implementation of new and more efficient processes, development of substitution technologies, material savings, and the invention of entirely new technologies that fulfill the same function without the need of using the scarce and suddenly more expensive material are effective reactions to a price rise. The effectiveness of this self-regulating mechanism can be shown by examples of historical price peaks of metals, such as Mo, Co, and Ta, and the current rare earth elements peak. Concerning supply from secondary resources, a model is developed in order to determine how far the supply from this resource domain can be achieved and how the recycling rate is influenced by growth rate and lifetime. The feedback control cycle of mineral supply is influenced on the demand side by ever shorter life cycles, by products getting more complex with ever more elements involved in their production, and by an increase in element dispersion. All these factors have an immediate effect on the feasibility of sourcing raw materials from the technosphere. The supply side of primary materials is influenced by increasing lead times

  16. A decision model for cost effective design of biomass based green energy supply chains.

    PubMed

    Yılmaz Balaman, Şebnem; Selim, Hasan

    2015-09-01

    The core driver of this study is to deal with the design of anaerobic digestion based biomass to energy supply chains in a cost effective manner. In this concern, a decision model is developed. The model is based on fuzzy multi objective decision making in order to simultaneously optimize multiple economic objectives and tackle the inherent uncertainties in the parameters and decision makers' aspiration levels for the goals. The viability of the decision model is explored with computational experiments on a real-world biomass to energy supply chain and further analyses are performed to observe the effects of different conditions. To this aim, scenario analyses are conducted to investigate the effects of energy crop utilization and operational costs on supply chain structure and performance measures.

  17. Mimicking bipolar sextupole power supplies for low-energy operations at RHIC

    SciTech Connect

    Montag, C.; Bruno, D.; Jain, A.; Robert-Demolaize, G.; Satogata, T.; Tepikian, S.

    2011-03-28

    RHIC operated at energies below the nominal ion injection energy of E=9.8 GeV/u in 2010. Earlier test runs and magnet measurements indicated that all defocusing sextupole unipolar power supplies should be reversed to provide the proper sign of chromaticity. However, vertical chromaticity at E=3.85 GeV/u with this power supply configuration was still not optimal. This uncertainty inspired a new machine configuration where only half of the defocusing sextupole power supplies were reversed, taking advantage of the flexibility of the RHIC nonlinear chromaticity correction system to mimic bipolar sextupoles. This configuration resulted in a 30 percent luminosity gain and eliminated the need for further polarity changes for later 2010 low energy physics operations. Here we describe the background to this problem, operational experience, and RHIC online model changes to implement this solution.

  18. A low jitter supply regulated charge pump PLL with self-calibration

    NASA Astrophysics Data System (ADS)

    Min, Chen; Yuntao, Liu; Zhichao, Li; Jingbo, Xiao; Jie, Chen

    2016-01-01

    This paper describes a ring oscillator based low jitter charge pump PLL with supply regulation and digital calibration. In order to combat power supply noise, a low drop output voltage regulator is implemented. The VCO gain is tunable by using the 4 bit control self-calibration technique. So that the optimal VCO gain is automatically selected and the process/temperature variation is compensated. Fabricated in the 0.13 μm CMOS process, the PLL achieves a frequency range of 100-400 MHz and occupies a 190 × 200 μm2 area. The measured RMS jitter is 5.36 ps at a 400 MHz operating frequency. Project supported by the National Key Basic Research and Development Program of China (No. 2015CB352100).

  19. P.L. 95-619, "National Energy Supply Policy Act" (NECPA) (1978)

    SciTech Connect

    2011-12-13

    The purposes of this Act are to provide for the regulation of interstate commerce, to reduce the growth in demand for energy, and to conserve non-renewable energy resources without inhibiting beneficial economic growth.

  20. Effect of microwave freeze drying on quality and energy supply in drying of barley grass.

    PubMed

    Cao, Xiaohuang; Zhang, Min; Mujumdar, Arun S; Zhong, Qifeng; Wang, Zhushang

    2017-08-22

    Young barley grass leaves are well-known for antioxidant substances of flavonoid and chlorophyll. However, low product quality and energy efficiency exist in dehydration of barley grass leaves. To improve energy supply and quality of barley grass, microwave heating instead of contact heat were applied for freeze drying of barley grass in pilot-scale at 1W/g, 1.5W/g and 2W/g, respectively; After drying, energy supply and quality parameters of color, moisture content, chlorophyll, flavonoids, odors of dried barley grass were determined for evaluating the feasibility of this study. MFD allowed low energy supply and high contents of chlorophyll and flavonoids. Lightness value of 60.0, green value of -11.5, and energy supply of 0.61KW.h/g occurred in 1.5 W/g MFD; whereas drying time (7 hours) decreased by 42%, compared to contact heating. Maximum content of flavonoid and chlorophyll was 11.7g/kg and 12.8g/kg of barley grass. Microwave heat leads to odor change larger than that contact heat in freeze drying of barley grass. MFD retains chlorophyll and flavonoids, colors and odors of samples and decreases energy consumption in freeze drying barley grass. This article is protected by copyright. All rights reserved.

  1. The status and impact of state and local regulation on private timber supply

    Treesearch

    John L. Greene; William C. Siegel

    1994-01-01

    State and local regulatory enactments that affect private forest management are identified and summarized. The results of a Delphi technique survey of the current  and long-term effects of such regulation on private timber harvests, and TAMM projec­ tions of  their impact on U.S. timber supply and price, are de­scribed.

  2. Understanding the influence of climate change on the embodied energy of water supply.

    PubMed

    Mo, Weiwei; Wang, Haiying; Jacobs, Jennifer M

    2016-05-15

    The current study aims to advance understandings on how and to what degree climate change will affect the life cycle chemical and energy uses of drinking water supply. A dynamic life cycle assessment was performed to quantify historical monthly operational embodied energy of a selected water supply system located in northeast US. Comprehensive multivariate and regression analyses were then performed to understand the statistical correlation among monthly life cycle energy consumptions, three water quality indicators (UV254, pH, and water temperature), and five climate indicators (monthly mean temperature, monthly mean maximum/minimum temperatures, total precipitation, and total snow fall). Thirdly, a calculation was performed to understand how volumetric and total life cycle energy consumptions will change under two selected IPCC emission scenarios (A2 and B1). It was found that volumetric life cycle energy consumptions are highest in winter months mainly due to the higher uses of natural gas in the case study system, but total monthly life cycle energy consumptions peak in both July and January because of the increasing water demand in summer months. Most of the variations in chemical and energy uses can be interpreted by water quality and climate variations except for the use of soda ash. It was also found that climate change might lead to an average decrease of 3-6% in the volumetric energy use of the case study system by the end of the century. This result combined with conclusions reached by previous climate versus water supply studies indicates that effects of climate change on drinking water supply might be highly dependent on the geographical location and treatment process of individual water supply systems.

  3. Evaluating Opportunities to Improve Material and Energy Impacts in Commodity Supply Chains.

    SciTech Connect

    Hanes, Rebecca J.; Carpenter, Alberta

    2016-06-28

    When evaluated at the process level, next-generation technologies may be more energy and emissions intensive than current technology. However, many advanced technologies have the potential to reduce material and energy consumption in upstream or downstream processing stages. In order to fully understand the benefits and consequences of technology deployment, next-generation technologies should be evaluated in context, as part of a supply chain. This work presents the Material Flows through Industry (MFI) scenario modeling tool. The MFI tool is a cradle-to-gate linear network model of the U.S. industrial sector that can model a wide range of manufacturing scenarios, including changes in production technology, increases in industrial energy efficiency, and substitution between functionally equivalent materials. The MFI tool was developed to perform supply chain scale analyses in order to quantify the impacts and benefits of next-generation technologies and materials at that scale. For the analysis presented in this paper, the MFI tool is utilized to explore a case study comparing a steel supply chain to the supply chains of several functionally equivalent materials. Several of the alternatives to the baseline steel supply chain include next-generation production technologies and materials. Results of the case study show that aluminum production scenarios can out-perform the steel supply chain by using either an advanced smelting technology or an increased aluminum recycling rate. The next-generation material supply chains do not perform as well as either aluminum or steel, but may offer additional use phase reductions in energy and emissions that are outside the scope of the MFI tool. Future work will combine results from the MFI tool with a use phase analysis.

  4. Energy supply and demand modeling. (Latest citations from the NTIS data base). Published Search

    SciTech Connect

    Not Available

    1992-10-01

    The bibliography contains citations concerning the use of mathematical models in trend analysis and forecasting of energy supply and demand factors. Models are presented for the industrial, transportation, and residential sectors. Aspects of long term energy strategies and markets are discussed at the global, national, state, and regional levels. Energy demand and pricing, and econometrics of energy, are explored for electric utilities and natural resources, such as coal, oil, and natural gas. Energy resources are modeled both for fuel usage and for reserves. (Contains 250 citations and includes a subject term index and title list.)

  5. Energy supply and demand modeling. (Latest citations from the NTIS bibliographic database). Published Search

    SciTech Connect

    Not Available

    1994-12-01

    The bibliography contains citations concerning the use of mathematical models in trend analysis and forecasting of energy supply and demand factors. Models are presented for the industrial, transportation, and residential sectors. Aspects of long term energy strategies and markets are discussed at the global, national, state, and regional levels. Energy demand and pricing, and econometrics of energy, are explored for electric utilities and natural resources, such as coal, oil, and natural gas. Energy resources are modeled both for fuel usage and for reserves. (Contains 250 citations and includes a subject term index and title list.)

  6. Energy supply and demand modeling. (Latest citations from the NTIS bibliographic database). Published Search

    SciTech Connect

    Not Available

    1994-01-01

    The bibliography contains citations concerning the use of mathematical models in trend analysis and forecasting of energy supply and demand factors. Models are presented for the industrial, transportation, and residential sectors. Aspects of long term energy strategies and markets are discussed at the global, national, state, and regional levels. Energy demand and pricing, and econometrics of energy, are explored for electric utilities and natural resources, such as coal, oil, and natural gas. Energy resources are modeled both for fuel usage and for reserves. (Contains 250 citations and includes a subject term index and title list.)

  7. Miscellaneous: Uruguay energy supply options study assessing the market for natural gas - executive summary.

    SciTech Connect

    Conzelmann, G.; Veselka, T.; Decision and Information Sciences

    2008-03-04

    Uruguay is in the midst of making critical decisions affecting the design of its future energy supply system. Momentum for change is expected to come from several directions, including recent and foreseeable upgrades and modifications to energy conversion facilities, the importation of natural gas from Argentina, the possibility for a stronger interconnection of regional electricity systems, the country's membership in MERCOSUR, and the potential for energy sector reforms by the Government of Uruguay. The objective of this study is to analyze the effects of several fuel diversification strategies on Uruguay's energy supply system. The analysis pays special attention to fuel substitution trends due to potential imports of natural gas via a gas pipeline from Argentina and increasing electricity ties with neighboring countries. The Government of Uruguay has contracted with Argonne National Laboratory (ANL) to study several energy development scenarios with the support of several Uruguayan institutions. Specifically, ANL was asked to conduct a detailed energy supply and demand analysis, develop energy demand projections based on an analysis of past energy demand patterns with support from local institutions, evaluate the effects of potential natural gas imports and electricity exchanges, and determine the market penetration of natural gas under various scenarios.

  8. Coalmines as Underground Pumped Storage Power Plants (UPP) - A Contribution to a Sustainable Energy Supply?

    NASA Astrophysics Data System (ADS)

    Luick, H.; Niemann, A.; Perau, E.; Schreiber, U.

    2012-04-01

    In Europe, electrical power generation from renewable energy sources rose by about 50% in the last 20 years. In Germany, renewable electricity is mainly provided by wind power and photovoltaic. Energy output depends on weather conditions like wind speed or solar radiation and may therefore vary considerably. Rapid fluctuations in power generation already require regulation of conventional power plants by the distribution network operators to stabilize and ensure grid frequency and overall system stability. In order to avoid future blackouts caused by intermittent energy sources, it is necessary to increase the storage capacity for electric power. Theoretically, there are many technologies for storing energy, like accumulators, hydrogen storage systems, biomethane facilities (hydrocarbon synthesis) or compressed air storage. Only a few technologies combine sufficient capacity, fast response, high efficiency, low storage loss and long-term application experience. A pumped storage power plant (PSPP) is a state of the art technology which combines all of these aspects. Energy is stored in form of potential energy by pumping water to an upper reservoir in times of energy surplus or low energy costs. In times of insufficient power supply or high energy costs, the water is released through turbines to produce electric energy. The efficiency of state-of-the-art systems is about 70-80%. The total head (geodetic height between upper and lower reservoirs) and the storage capacity of the reservoirs as given in a mountainous terrain, determine the energy storage capacity of a PSPP. An alternative is the use of man-made geodetic height differences as given in ore, coal or open cast lignite mines. In these cases, the lower reservoir of the plant is located in the drifts or at the bottom of the mine. Energieforschungszentrum Niedersachsen (EFZN) has already explored the installation of a PSPP in abandoned ore mines in the Harz-region/Germany (Beck 2011). In 2011/2012 a basic

  9. Innovation, Diffusion, and Regulation in Energy Technologies

    NASA Astrophysics Data System (ADS)

    Fetter, Theodore Robert

    The innovation and diffusion of new technologies is one of the central concerns of economics. New inventions or technological combinations do not spring fully formed into the world; as firms encounter and learn about new technologies they experiment, refine, and learn about them, improving productivity (and sometimes earning economic rents). Understanding the processes by which firms learn, and how these processes interact with regulations, is fundamental to understanding the emergence of new technologies, their contribution to growth, and the interaction of innovation and regulation. This dissertation addresses how firms learn and respond to regulations in the context of emerging technologies. Within this framework, I address several questions. When production inputs are socially controversial, do firms respond to disclosure laws by voluntarily constraining their inputs? Do these public disclosure laws facilitate knowledge transmission across firms, and if so, what are the implications for public welfare - for instance, do the gains from trade outweigh any effects of reduced incentives for innovation? I study these questions in the context of hydraulic fracturing, though the results offer insight for more general settings. Panning out to a much broader view, I also explore how energy-related technologies - in both generation and consumption - diffuse across national boundaries over time, and whether innovation and diffusion of energy-efficient technologies has led to more or less energy-efficient economic growth. In my first paper, I contribute to improved understanding of the conditions in which information-based regulations, which are increasingly common in multiple policy domains, decrease externalities such as environmental pollution. Specifically, I test whether information disclosure regulations applied to hydraulic fracturing chemicals caused firms to decrease their use of toxic inputs. Prior to these mandatory disclosure laws, some operators voluntarily

  10. Integrated energy and media supply concepts for long-term space missions

    NASA Astrophysics Data System (ADS)

    Schwarzott, W.; Reich, G.; Denner, W.-J.

    In order to minimize the operational cost of future long-term manned space missions, an integrated regenerative energy and media supply system (EMSS) for spacecraft and Space Station is proposed. Based on H2/O2- technology, the first step into a regenerative EMSS could be the integration of the subsystems energy supply, environmental control and life support (ECLS) as well as attitude and orbit control (AOC). Further extension of such a system may also comprise the nutrition system including then further elements as N 2 and C. Electrolyser and fuel cell systems play an important role within EMSS as energy converter while solar dynamic energy supply systems may offer thermal energy in parallel to electricity. Simultaneous availability of thermal and electric energy including adequate storage facilities will form an optimum basis to a variety of different chemical recycling processes as well as media and energy conversion. The motivation for such a technology is presented, the technical characteristics of subsystems technology are summarized and the first approaches of possible concepts are developed. Step by step solutions seem possible so that pilot test plants of low degree of integration may be investigated already in the course of the planned Space Station.

  11. NOX4 regulates autophagy during energy deprivation

    PubMed Central

    Sciarretta, Sebastiano; Volpe, Massimo; Sadoshima, Junichi

    2014-01-01

    NADPH oxidase is a cellular enzyme devoted to the production of reactive oxygen species (ROS). NOX4 and NOX2 are the main isoforms of NADPH oxidase in the cardiovascular system. In our recent study, we demonstrated that NOX4, but not NOX2, is a critical mediator of the cardiomyocyte adaptive response to energy stress. NOX4 activity and protein levels are increased in the endoplasmic reticulum (ER) but not in mitochondria of cardiomyocytes during the early phase of energy deprivation. NOX4-derived production of ROS in the ER is a critical event that activates autophagy through stimulation of the EIF2AK3/PERK-EIF2S1/eIF-2α-ATF4 pathway. NOX4-dependent autophagy is an important mechanism to preserve cellular energy and limit cell death in energy-deprived cardiomyocytes. Aside from elucidating a crucial physiological function of NOX4 during cellular energy stress, our study dissects a novel signaling mechanism that regulates autophagy under this condition. PMID:24492492

  12. NOX4 regulates autophagy during energy deprivation.

    PubMed

    Sciarretta, Sebastiano; Volpe, Massimo; Sadoshima, Junichi

    2014-04-01

    NADPH oxidase is a cellular enzyme devoted to the production of reactive oxygen species (ROS). NOX4 and NOX2 are the main isoforms of NADPH oxidase in the cardiovascular system. In our recent study, we demonstrated that NOX4, but not NOX2, is a critical mediator of the cardiomyocyte adaptive response to energy stress. NOX4 activity and protein levels are increased in the endoplasmic reticulum (ER) but not in mitochondria of cardiomyocytes during the early phase of energy deprivation. NOX4-derived production of ROS in the ER is a critical event that activates autophagy through stimulation of the EIF2AK3/PERK-EIF2S1/eIF-2α-ATF4 pathway. NOX4-dependent autophagy is an important mechanism to preserve cellular energy and limit cell death in energy-deprived cardiomyocytes. Aside from elucidating a crucial physiological function of NOX4 during cellular energy stress, our study dissects a novel signaling mechanism that regulates autophagy under this condition.

  13. Short-Term Energy Outlook Model Documentation: Petroleum Products Supply Module

    EIA Publications

    2013-01-01

    The Petroleum Products Supply Module of the Short-Term Energy Outlook (STEO) model provides forecasts of petroleum refinery inputs (crude oil, unfinished oils, pentanes plus, liquefied petroleum gas, motor gasoline blending components, and aviation gasoline blending components) and refinery outputs (motor gasoline, jet fuel, distillate fuel, residual fuel, liquefied petroleum gas, and other petroleum products).

  14. Short-Term Energy Outlook Model Documentation: Petroleum Products Supply Module

    EIA Publications

    2013-01-01

    The Petroleum Products Supply Module of the Short-Term Energy Outlook (STEO) model provides forecasts of petroleum refinery inputs (crude oil, unfinished oils, pentanes plus, liquefied petroleum gas, motor gasoline blending components, and aviation gasoline blending components) and refinery outputs (motor gasoline, jet fuel, distillate fuel, residual fuel, liquefied petroleum gas, and other petroleum products).

  15. Minimax Analysis of Economic and Energy Efficiencies of Heat-Supply Pipelines

    NASA Astrophysics Data System (ADS)

    Sabdenov, K. O.

    2016-11-01

    A minimax problem of minimization of financial expenses and energy expenditure in a heat-supply system of buildings has been formulated and solved. The optimum parameters of a pipeline, i.e., the pipe radius and the thickness of the heat-insulating material, have been found.

  16. Willingness of nonindustrial private forest owners in Norway to supply logging residues for wood energy

    Treesearch

    Hanne K. Sjolie; Dennis Becker; Daniel Habesland; Birger Solberg; Berit Hauger Lindstad; Stephanie Snyder; Mike. Kilgore

    2016-01-01

    Norway has set ambitious targets for increasing bioenergy production. Forest residue extraction levels are currently very low, but residues have the potential to be an important component of the wood energy supply chain. A representative sample of Norwegian nonindustrial private forest owners having at least 8 ha (20 acres) of productive forest land was surveyed about...

  17. Forecasting optimal solar energy supply in Jiangsu Province (China): a systematic approach using hybrid of weather and energy forecast models.

    PubMed

    Zhao, Xiuli; Asante Antwi, Henry; Yiranbon, Ethel

    2014-01-01

    The idea of aggregating information is clearly recognizable in the daily lives of all entities whether as individuals or as a group, since time immemorial corporate organizations, governments, and individuals as economic agents aggregate information to formulate decisions. Energy planning represents an investment-decision problem where information needs to be aggregated from credible sources to predict both demand and supply of energy. To do this there are varying methods ranging from the use of portfolio theory to managing risk and maximizing portfolio performance under a variety of unpredictable economic outcomes. The future demand for energy and need to use solar energy in order to avoid future energy crisis in Jiangsu province in China require energy planners in the province to abandon their reliance on traditional, "least-cost," and stand-alone technology cost estimates and instead evaluate conventional and renewable energy supply on the basis of a hybrid of optimization models in order to ensure effective and reliable supply. Our task in this research is to propose measures towards addressing optimal solar energy forecasting by employing a systematic optimization approach based on a hybrid of weather and energy forecast models. After giving an overview of the sustainable energy issues in China, we have reviewed and classified the various models that existing studies have used to predict the influences of the weather influences and the output of solar energy production units. Further, we evaluate the performance of an exemplary ensemble model which combines the forecast output of two popular statistical prediction methods using a dynamic weighting factor.

  18. Forecasting Optimal Solar Energy Supply in Jiangsu Province (China): A Systematic Approach Using Hybrid of Weather and Energy Forecast Models

    PubMed Central

    Zhao, Xiuli; Yiranbon, Ethel

    2014-01-01

    The idea of aggregating information is clearly recognizable in the daily lives of all entities whether as individuals or as a group, since time immemorial corporate organizations, governments, and individuals as economic agents aggregate information to formulate decisions. Energy planning represents an investment-decision problem where information needs to be aggregated from credible sources to predict both demand and supply of energy. To do this there are varying methods ranging from the use of portfolio theory to managing risk and maximizing portfolio performance under a variety of unpredictable economic outcomes. The future demand for energy and need to use solar energy in order to avoid future energy crisis in Jiangsu province in China require energy planners in the province to abandon their reliance on traditional, “least-cost,” and stand-alone technology cost estimates and instead evaluate conventional and renewable energy supply on the basis of a hybrid of optimization models in order to ensure effective and reliable supply. Our task in this research is to propose measures towards addressing optimal solar energy forecasting by employing a systematic optimization approach based on a hybrid of weather and energy forecast models. After giving an overview of the sustainable energy issues in China, we have reviewed and classified the various models that existing studies have used to predict the influences of the weather influences and the output of solar energy production units. Further, we evaluate the performance of an exemplary ensemble model which combines the forecast output of two popular statistical prediction methods using a dynamic weighting factor. PMID:24511292

  19. Application of programmable logic controller to pump regulation system for supplying water

    NASA Astrophysics Data System (ADS)

    Ye, Dao-Yi; Yang, Yong-Bin; Lu, Zong-Qi

    This paper describes a pump regulation system for supplying-water. The controlled variable is the output water pressure for supplying-water pumps. The reference input signal is given in PLC. The water pressure for supplying-water pump output is fed back by a A/D converter to CPU in PLC. The output of Programmable Logic Controller Controls a frequency converter. The frequency converter controls three groups of motor-pump. The water from the three pumps enters the same pipe. Programmable Logic Controller (PLC) uses Ladder-shaped diagram software to implement logical control and proportional-plus-integral control. The method for automatic tuning of regulator of the PID type is based on a simple identification method which gives one point on the Nyquist curve of the open loop transfer function. The key idea is a scheme which provides automatic excitation of the process which is nearly optimal for estimating the desired process characteristics. Only a frequency converter controls several groups of motor pumps, therefore, the cost of the system is decreased. This system has electrically breaking off protection function and automatically restoring software. Through a long time operation, the system can work well.

  20. Modeling the influence of various water stressors on regional water supply infrastructures and their embodied energy

    NASA Astrophysics Data System (ADS)

    Mo, Weiwei; Zhang, Qiong

    2016-06-01

    Water supply consumes a substantial amount of energy directly and indirectly. This study aims to provide an enhanced understanding of the influence of water stressors on the embodied energy of water supply (EEWS). To achieve this goal, the EEWS in 75 North Carolina counties was estimated through an economic input-output based hybrid life cycle assessment. Ten water stressor indicators related to population, economic development, climate, water source, and land use were obtained for the 75 counties. A multivariate analysis was performed to understand the correlations between water stressor indicators and the EEWS. A regression analysis was then conducted to identify the statistically significant indicators in describing the EEWS. It was found that the total amount of water supply energy varies significantly among selected counties. Water delivery presents the highest energy use and water storage presents the least. The total embodied energy was found to be highly correlated with total population. The regression analysis shows that the total embodied energy can be best described by total population and temperature indicators with a relatively high R square value of 0.69.

  1. Advanced Building Efficiency Testbed Initiative/Intelligent Workplace Energy Supply System; ABETI/IWESS

    SciTech Connect

    David Archer; Frederik Betz; Yun Gu; Rong Li; Flore Marion; Sophie Masson; Ming Qu; Viraj Srivastava; Hongxi Yin; Chaoqin Zhai; Rui Zhang; Elisabeth Aslanian; Berangere Lartigue

    2008-05-31

    ABETI/IWESS is a project carried out by Carnegie Mellon's Center for Building Performance and Diagnostics, the CBPD, supported by the U.S. Department of Energy/EERE, to design, procure, install, operate, and evaluate an energy supply system, an ESS, that will provide power, cooling, heating and ventilation for CBPD's Intelligent Workplace, the IW. The energy sources for this system, the IWESS, are solar radiation and bioDiesel fuel. The components of this overall system are: (1) a solar driven cooling and heating system for the IW comprising solar receivers, an absorption chiller, heat recovery exchanger, and circulation pump; (2) a bioDiesel fueled engine generator with heat recovery exchangers, one on the exhaust to provide steam and the other on the engine coolant to provide heated water; (3) a ventilation system including an enthalpy recovery wheel, an air based heat pump, an active desiccant wheel, and an air circulation fan; and (4) various convective and radiant cooling/heating units and ventilation air diffusers distributed throughout the IW. The goal of the ABETI/IWESS project is to demonstrate an energy supply system for a building space that will provide a healthy, comfortable environment for the occupants and that will reduce the quantity of energy consumed in the operation of a building space by a factor of 2 less than that of a conventional energy supply for power, cooling, heating, and ventilation based on utility power and natural gas fuel for heating.

  2. Membrane Supply and Demand Regulates F-Actin in a Cell Surface Reservoir.

    PubMed

    Figard, Lauren; Wang, Mengyu; Zheng, Liuliu; Golding, Ido; Sokac, Anna Marie

    2016-05-09

    Cells store membrane in surface reservoirs of pits and protrusions. These membrane reservoirs facilitate cell shape change and buffer mechanical stress, but we do not know how reservoir dynamics are regulated. During cellularization, the first cytokinesis in Drosophila embryos, a reservoir of microvilli unfolds to fuel cleavage furrow ingression. We find that regulated exocytosis adds membrane to the reservoir before and during unfolding. Dynamic F-actin deforms exocytosed membrane into microvilli. Single microvilli extend and retract in ∼20 s, while the overall reservoir is depleted in sync with furrow ingression over 60-70 min. Using pharmacological and genetic perturbations, we show that exocytosis promotes microvillar F-actin assembly, while furrow ingression controls microvillar F-actin disassembly. Thus, reservoir F-actin and, consequently, reservoir dynamics are regulated by membrane supply from exocytosis and membrane demand from furrow ingression.

  3. 10 CFR Appendix Z to Subpart B of... - Uniform Test Method for Measuring the Energy Consumption of External Power Supplies

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... established by IEC Standard 62301 for measuring average power or accumulated energy over time for both input... 10 Energy 3 2013-01-01 2013-01-01 false Uniform Test Method for Measuring the Energy Consumption of External Power Supplies Z Appendix Z to Subpart B of Part 430 Energy DEPARTMENT OF ENERGY ENERGY...

  4. 10 CFR Appendix Z to Subpart B of... - Uniform Test Method for Measuring the Energy Consumption of External Power Supplies

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Uniform Test Method for Measuring the Energy Consumption of External Power Supplies Z Appendix Z to Subpart B of Part 430 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CONSERVATION PROGRAM FOR CONSUMER PRODUCTS Test Procedures Pt. 430, Subpt. B, App. Z...

  5. Development of compact rapid charging power supply for capacitive energy storage in pulsed power drivers.

    PubMed

    Sharma, Surender Kumar; Shyam, Anurag

    2015-02-01

    High energy capacitor bank is used for primary electrical energy storage in pulsed power drivers. The capacitors used in these pulsed power drivers have low inductance, low internal resistance, and less dc life, so it has to be charged rapidly and immediately discharged into the load. A series resonant converter based 45 kV compact power supply is designed and developed for rapid charging of the capacitor bank with constant charging current up to 150 mA. It is short circuit proof, and zero current switching technique is used to commute the semiconductor switch. A high frequency resonant inverter switching at 10 kHz makes the overall size small and reduces the switching losses. The output current of the power supply is limited by constant on-time and variable frequency switching control technique. The power supply is tested by charging the 45 kV/1.67 μF and 15 kV/356 μF capacitor banks. It has charged the capacitor bank up to rated voltage with maximum charging current of 150 mA and the average charging rate of 3.4 kJ/s. The output current of the power supply is limited by reducing the switching frequency at 5 kHz, 3.3 kHz, and 1.7 kHz and tested with 45 kV/1.67 μF capacitor bank. The protection circuit is included in the power supply for over current, under voltage, and over temperature. The design details and the experimental testing results of the power supply for resonant current, output current, and voltage traces of the power supply with capacitive, resistive, and short circuited load are presented and discussed.

  6. Development of compact rapid charging power supply for capacitive energy storage in pulsed power drivers

    NASA Astrophysics Data System (ADS)

    Sharma, Surender Kumar; Shyam, Anurag

    2015-02-01

    High energy capacitor bank is used for primary electrical energy storage in pulsed power drivers. The capacitors used in these pulsed power drivers have low inductance, low internal resistance, and less dc life, so it has to be charged rapidly and immediately discharged into the load. A series resonant converter based 45 kV compact power supply is designed and developed for rapid charging of the capacitor bank with constant charging current up to 150 mA. It is short circuit proof, and zero current switching technique is used to commute the semiconductor switch. A high frequency resonant inverter switching at 10 kHz makes the overall size small and reduces the switching losses. The output current of the power supply is limited by constant on-time and variable frequency switching control technique. The power supply is tested by charging the 45 kV/1.67 μF and 15 kV/356 μF capacitor banks. It has charged the capacitor bank up to rated voltage with maximum charging current of 150 mA and the average charging rate of 3.4 kJ/s. The output current of the power supply is limited by reducing the switching frequency at 5 kHz, 3.3 kHz, and 1.7 kHz and tested with 45 kV/1.67 μF capacitor bank. The protection circuit is included in the power supply for over current, under voltage, and over temperature. The design details and the experimental testing results of the power supply for resonant current, output current, and voltage traces of the power supply with capacitive, resistive, and short circuited load are presented and discussed.

  7. An Overview of Seafood Supply, Food Safety and Regulation in New South Wales, Australia

    PubMed Central

    Hussain, Malik A.; Saputra, Themy; Szabo, Elizabeth A.; Nelan, Bruce

    2017-01-01

    Seafood consumption is increasing in Australia, especially in New South Wales (NSW). Average per capita seafood consumption in NSW is higher than the national average. Seafood supply in NSW comes from domestic (wild catch and aquaculture) and overseas (seafood imports) sources. The contribution of wild catch and aquaculture in domestic seafood production (2012–2013) was 73.42% and 26.52%, respectively. Seafood-associated foodborne illness outbreaks are not common and on an average four outbreaks occur each year in NSW. Most of the outbreaks in 2015 and 2016 were related to ciguatera poisoning. The regulation of the seafood industry and the management of food safety is an example of the coordinated work of multiple government agencies and organizations in which NSW Food Authority is responsible for managing the overall risks through the Seafood Safety Scheme. Overall, seafood supply in NSW is of high quality and poses low food safety risk to consumers. PMID:28753923

  8. The cardiac cycle: regulation and energy oscillations.

    PubMed

    Wikman-Coffelt, J; Sievers, R; Coffelt, R J; Parmley, W W

    1983-08-01

    Cyclical changes in energy-related metabolites were observed in glucose-perfused but not pyruvate-perfused isolated working rat hearts. A chronological study of various phases of the cardiac cycle indicated maximum changes in metabolites occurred at half time to peak pressure (dF/dtmax). The high-energy phosphates ATP and phosphocreatine, as well as the glycolytic metabolites, glucose 6-phosphate and pyruvate, reached minimum values immediately prior to peak systole and maximum values during late diastole. The products of high-energy phosphate hydrolysis, ADP, inorganic phosphate, and creatine, as well as the regulator, adenosine 3',5'-cyclic monophosphate, showed the phase alternate. It was necessary to study cyclical changes in a maximally stressed glucose-perfused heart because the cyclical changes were small and appeared to be the result of rate-limiting steps in glycolysis and the slow transport of NADH into the mitochondria. For stressing the heart, thereby increasing ATP utilization and augmenting cyclical changes, the afterload chamber was set at 110 mmHg, and the perfusate contained high concentrations of calcium (3.5 mM, free) and isoproterenol (5 X 10(-9) M). When correction was made for binding and compartmentation of metabolites, data indicated that the free energy of ATP hydrolysis was preserved during the contraction process by a continuous binding and recycling of ADP.

  9. Forecasting jobs in the supply chain for investments in residential energy efficiency retrofits in Florida

    NASA Astrophysics Data System (ADS)

    Fobair, Richard C., II

    This research presents a model for forecasting the numbers of jobs created in the energy efficiency retrofit (EER) supply chain resulting from an investment in upgrading residential buildings in Florida. This investigation examined material supply chains stretching from mining to project installation for three product types: insulation, windows/doors, and heating, ventilating, and air conditioning (HVAC) systems. Outputs from the model are provided for the project, sales, manufacturing, and mining level. The model utilizes reverse-estimation to forecast the numbers of jobs that result from an investment. Reverse-estimation is a process that deconstructs a total investment into its constituent parts. In this research, an investment is deconstructed into profit, overhead, and hard costs for each level of the supply chain and over multiple iterations of inter-industry exchanges. The model processes an investment amount, the type of work and method of contracting into a prediction of the number of jobs created. The deconstruction process utilizes data from the U.S. Economic Census. At each supply chain level, the cost of labor is reconfigured into full-time equivalent (FTE) jobs (i.e. equivalent to 40 hours per week for 52 weeks) utilizing loaded labor rates and a typical employee mix. The model is sensitive to adjustable variables, such as percentage of work performed per type of product, allocation of worker time per skill level, annual hours for FTE calculations, wage rate, and benefits. This research provides several new insights into job creation. First, it provides definitions that can be used for future research on jobs in supply chains related to energy efficiency. Second, it provides a methodology for future investigators to calculate jobs in a supply chain resulting from an investment in energy efficiency upgrades to a building. The methodology used in this research is unique because it examines gross employment at the sub-industry level for specific

  10. 77 FR 22472 - Energy Conservation Program: Energy Conservation Standards for Certain External Power Supplies...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-16

    .... Department of Energy, Office of Energy Efficiency and Renewable Energy, Building Technologies Program, EE-2J...)) Those standards consisted of minimum efficiency levels that these products must meet during active mode... April 9, 2012. Kathleen B. Hogan, Deputy Assistant Secretary for Energy Efficiency, Energy...

  11. Nanotechnology and clean energy: sustainable utilization and supply of critical materials

    NASA Astrophysics Data System (ADS)

    Fromer, Neil A.; Diallo, Mamadou S.

    2013-11-01

    Advances in nanoscale science and engineering suggest that many of the current problems involving the sustainable utilization and supply of critical materials in clean and renewable energy technologies could be addressed using (i) nanostructured materials with enhanced electronic, optical, magnetic and catalytic properties and (ii) nanotechnology-based separation materials and systems that can recover critical materials from non-traditional sources including mine tailings, industrial wastewater and electronic wastes with minimum environmental impact. This article discusses the utilization of nanotechnology to improve or achieve materials sustainability for energy generation, conversion and storage. We highlight recent advances and discuss opportunities of utilizing nanotechnology to address materials sustainability for clean and renewable energy technologies.

  12. Waste biomass-to-energy supply chain management: a critical synthesis.

    PubMed

    Iakovou, E; Karagiannidis, A; Vlachos, D; Toka, A; Malamakis, A

    2010-10-01

    The development of renewable energy sources has clearly emerged as a promising policy towards enhancing the fragile global energy system with its limited fossil fuel resources, as well as for reducing the related environmental problems. In this context, waste biomass utilization has emerged as a viable alternative for energy production, encompassing a wide range of potential thermochemical, physicochemical and bio-chemical processes. Two significant bottlenecks that hinder the increased biomass utilization for energy production are the cost and complexity of its logistics operations. In this manuscript, we present a critical synthesis of the relative state-of-the-art literature as this applies to all stakeholders involved in the design and management of waste biomass supply chains (WBSCs). We begin by presenting the generic system components and then the unique characteristics of WBSCs that differentiate them from traditional supply chains. We proceed by discussing state-of-the-art energy conversion technologies along with the resulting classification of all relevant literature. We then recognize the natural hierarchy of the decision-making process for the design and planning of WBSCs and provide a taxonomy of all research efforts as these are mapped on the relevant strategic, tactical and operational levels of the hierarchy. Our critical synthesis demonstrates that biomass-to-energy production is a rapidly evolving research field focusing mainly on biomass-to-energy production technologies. However, very few studies address the critical supply chain management issues, and the ones that do that, focus mainly on (i) the assessment of the potential biomass and (ii) the allocation of biomass collection sites and energy production facilities. Our analysis further allows for the identification of gaps and overlaps in the existing literature, as well as of critical future research areas.

  13. Energy Harvesting Chip and the Chip Based Power Supply Development for a Wireless Sensor Network.

    PubMed

    Lee, Dasheng

    2008-12-02

    In this study, an energy harvesting chip was developed to scavenge energy from artificial light to charge a wireless sensor node. The chip core is a miniature transformer with a nano-ferrofluid magnetic core. The chip embedded transformer can convert harvested energy from its solar cell to variable voltage output for driving multiple loads. This chip system yields a simple, small, and more importantly, a battery-less power supply solution. The sensor node is equipped with multiple sensors that can be enabled by the energy harvesting power supply to collect information about the human body comfort degree. Compared with lab instruments, the nodes with temperature, humidity and photosensors driven by harvested energy had variation coefficient measurement precision of less than 6% deviation under low environmental light of 240 lux. The thermal comfort was affected by the air speed. A flow sensor equipped on the sensor node was used to detect airflow speed. Due to its high power consumption, this sensor node provided 15% less accuracy than the instruments, but it still can meet the requirement of analysis for predicted mean votes (PMV) measurement. The energy harvesting wireless sensor network (WSN) was deployed in a 24-hour convenience store to detect thermal comfort degree from the air conditioning control. During one year operation, the sensor network powered by the energy harvesting chip retained normal functions to collect the PMV index of the store. According to the one month statistics of communication status, the packet loss rate (PLR) is 2.3%, which is as good as the presented results of those WSNs powered by battery. Referring to the electric power records, almost 54% energy can be saved by the feedback control of an energy harvesting sensor network. These results illustrate that, scavenging energy not only creates a reliable power source for electronic devices, such as wireless sensor nodes, but can also be an energy source by building an energy efficient

  14. Energy Harvesting Chip and the Chip Based Power Supply Development for a Wireless Sensor Network

    PubMed Central

    Lee, Dasheng

    2008-01-01

    In this study, an energy harvesting chip was developed to scavenge energy from artificial light to charge a wireless sensor node. The chip core is a miniature transformer with a nano-ferrofluid magnetic core. The chip embedded transformer can convert harvested energy from its solar cell to variable voltage output for driving multiple loads. This chip system yields a simple, small, and more importantly, a battery-less power supply solution. The sensor node is equipped with multiple sensors that can be enabled by the energy harvesting power supply to collect information about the human body comfort degree. Compared with lab instruments, the nodes with temperature, humidity and photosensors driven by harvested energy had variation coefficient measurement precision of less than 6% deviation under low environmental light of 240 lux. The thermal comfort was affected by the air speed. A flow sensor equipped on the sensor node was used to detect airflow speed. Due to its high power consumption, this sensor node provided 15% less accuracy than the instruments, but it still can meet the requirement of analysis for predicted mean votes (PMV) measurement. The energy harvesting wireless sensor network (WSN) was deployed in a 24-hour convenience store to detect thermal comfort degree from the air conditioning control. During one year operation, the sensor network powered by the energy harvesting chip retained normal functions to collect the PMV index of the store. According to the one month statistics of communication status, the packet loss rate (PLR) is 2.3%, which is as good as the presented results of those WSNs powered by battery. Referring to the electric power records, almost 54% energy can be saved by the feedback control of an energy harvesting sensor network. These results illustrate that, scavenging energy not only creates a reliable power source for electronic devices, such as wireless sensor nodes, but can also be an energy source by building an energy efficient

  15. Requirements and potential development pathways for fission energy supply infrastructures of the 21st century - a systems viewpoint.

    SciTech Connect

    Wade, D. C.

    1999-06-14

    Using an energy supply systems approach, we envision attributes and characteristic needs of a future global fission-based energy supply infrastructure, enumerate potential pathways for meeting those needs, and identify the underlying enabling science and technology developments for R and D efforts to meet the needs.

  16. Regulation of Kidney Function and Metabolism: A Question of Supply and Demand

    PubMed Central

    Blantz, Roland C.; Deng, Aihua; Miracle, Cynthia M.; Thomson, Scott C.

    2007-01-01

    Kidney blood flow and glomerular filtration rate (GFR) are maintained relatively constant by hormonal influences and by efficient autoregulation. However, the kidney remains at risk for ischemia and acute kidney injury. Increases in kidney blood flow cause parallel increments in GFR, thereby dictating tubular reabsorption and increased oxygen/metabolic demands. Coordination between kidney blood flow and GFR with tubular reabsorption is maintained by the tubuloglomerular feedback (TGF) system whereby delivery of NaCl to the macula densa varies inversely with nephron GFR. Metabolic products, ATP and adenosine, are the mediators of TGF via afferent arteriolar vasoconstriction, and nitric oxide; COX-2 products and angiotensin II are modulators of acute TGF responses and temporal adaptation of TGF. Oxygen requirements and metabolic efficiency of Na transport in the kidney are significant variables that are regulated by both mediators and modulators of TGF. These metabolic and hormonal substances efficiently regulate both kidney supply and demand. PMID:18528487

  17. Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells

    PubMed Central

    Cai, Ming; He, Jingquan; Xiong, Jian; Tay, Li Wei Rachel; Wang, Ziqing; Rog, Colin; Wang, Jingshu; Xie, Yizhao; Wang, Guobin; Banno, Yoshiko; Li, Feng; Zhu, Michael; Du, Guangwei

    2016-01-01

    Cancer cells utilize flexible metabolic programs to maintain viability and proliferation under stress conditions including nutrient deprivation. Here we report that phospholipase D1 (PLD1) participates in the regulation of metabolic plasticity in cancer cells. PLD1 activity is required for cancer cell survival during prolonged glucose deprivation. Blocking PLD1 sensitizes cancer cells to glycolysis inhibition by 2-deoxy-D-glucose (2-DG) and results in decreased autophagic flux, enlarged lysosomes, and increased lysosomal pH. Mechanistically, PLD1-regulated autophagy hydrolyzes bulk membrane phospholipids to supply fatty acids (FAs) for oxidation in mitochondria. In low glucose cultures, the blockade of fatty acid oxidation (FAO) by PLD1 inhibition suppresses adenosine triphosphate (ATP) production and increases reactive oxygen species (ROS), leading to cancer cell death. In summary, our findings reveal a novel role of PLD1 in sustaining cancer cell survival during metabolic stress, and suggest PLD1 as a potential target for anticancer metabolism therapy. PMID:27809301

  18. The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching.

    PubMed

    Umbrello, Michele; Dyson, Alex; Feelisch, Martin; Singer, Mervyn

    2013-11-10

    A mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow--hypoxic vasodilation--occur in an attempt to restore oxygen supply. Nitric oxide (NO) is a major signaling and effector molecule mediating the body's response to hypoxia, given its unique characteristics of vasodilation (improving blood flow and oxygen supply) and modulation of energetic metabolism (reducing oxygen consumption and promoting utilization of alternative pathways). This review covers the role of oxygen in metabolism and responses to hypoxia, the hemodynamic and metabolic effects of NO, and mechanisms underlying the involvement of NO in hypoxic vasodilation. Recent insights into NO metabolism will be discussed, including the role for dietary intake of nitrate, endogenous nitrite (NO₂⁻) reductases, and release of NO from storage pools. The processes through which NO levels are elevated during hypoxia are presented, namely, (i) increased synthesis from NO synthases, increased reduction of NO₂⁻ to NO by heme- or pterin-based enzymes and increased release from NO stores, and (ii) reduced deactivation by mitochondrial cytochrome c oxidase. Several reviews covered modulation of energetic metabolism by NO, while here we highlight the crucial role NO plays in achieving cardiocirculatory homeostasis during acute hypoxia through both vasodilation and metabolic suppression. We identify a key position for NO in the body's adaptation to an acute energy supply-demand mismatch.

  19. Single Event Transients in Voltage Regulators for FPGA Power Supply Applications

    NASA Technical Reports Server (NTRS)

    Poivey, Christian; Sanders, Anthony; Kim, Hak; Phan, Anthony; Forney, Jim; LaBel, Kenneth A.; Karsh, Jeremy; Pursley, Scott; Kleyner, Igor; Katz, Richard

    2006-01-01

    As with other bipolar analog devices, voltage regulators are known to be sensitive to single event transients (SET). In typical applications, large output capacitors are used to provide noise immunity. Therefore, since SET amplitude and duration are generally small, they are often of secondary importance due to this capacitance filtering. In low voltage applications, however, even small SET are a concern. Over-voltages may cause destructive conditions. Under-voltages may cause functional interrupts and may also trigger electrical latchup conditions. In addition, internal protection circuits which are affected by load as well as internal thermal effects can also be triggered from heavy ions, causing dropouts or shutdown ranging from milliseconds to seconds. In the case of FPGA power supplies applications, SETS are critical. For example, in the case of Actel FPGA RTAX family, core power supply voltage is 1.5V. Manufacturer specifies an absolute maximum rating of 1.6V and recommended operating conditions between 1.425V and 1.575V. Therefore, according to the manufacturer, any transient of amplitude greater than 75 mV can disrupt normal circuit functions, and overvoltages greater than 100 mV may damage the FPGA. We tested five low dropout voltage regulators for SET sensitivity under a large range of circuit application conditions.

  20. Impact of enhanced geothermal systems on US energy supply in the twenty-first century.

    PubMed

    Tester, Jefferson W; Anderson, Brian J; Batchelor, Anthony S; Blackwell, David D; DiPippo, Ronald; Drake, Elisabeth M; Garnish, John; Livesay, Bill; Moore, Michal C; Nichols, Kenneth; Petty, Susan; Toksoz, M Nafi; Veatch, Ralph W; Baria, Roy; Augustine, Chad; Murphy, Enda; Negraru, Petru; Richards, Maria

    2007-04-15

    Recent national focus on the value of increasing US supplies of indigenous renewable energy underscores the need for re-evaluating all alternatives, particularly those that are large and well distributed nationally. A panel was assembled in September 2005 to evaluate the technical and economic feasibility of geothermal becoming a major supplier of primary energy for US base-load generation capacity by 2050. Primary energy produced from both conventional hydrothermal and enhanced (or engineered) geothermal systems (EGS) was considered on a national scale. This paper summarizes the work of the panel which appears in complete form in a 2006 MIT report, 'The future of geothermal energy' parts 1 and 2. In the analysis, a comprehensive national assessment of US geothermal resources, evaluation of drilling and reservoir technologies and economic modelling was carried out. The methodologies employed to estimate geologic heat flow for a range of geothermal resources were utilized to provide detailed quantitative projections of the EGS resource base for the USA. Thirty years of field testing worldwide was evaluated to identify the remaining technology needs with respect to drilling and completing wells, stimulating EGS reservoirs and converting geothermal heat to electricity in surface power and energy recovery systems. Economic modelling was used to develop long-term projections of EGS in the USA for supplying electricity and thermal energy. Sensitivities to capital costs for drilling, stimulation and power plant construction, and financial factors, learning curve estimates, and uncertainties and risks were considered.

  1. An assessment of climate change impacts on micro-hydropower energy recovery in water supply networks

    NASA Astrophysics Data System (ADS)

    Brady, Jennifer; Patil, Sopan; McNabola, Aonghus; Gallagher, John; Coughlan, Paul; Harris, Ian; Packwood, Andrew; Williams, Prysor

    2015-04-01

    Continuity of service of a high quality water supply is vital in sustaining economic and social development. However, water supply and wastewater treatment are highly energy intensive processes and the overall cost of water provision is rising rapidly due to increased energy costs, higher capital investment requirements, and more stringent regulatory compliance in terms of both national and EU legislation. Under the EU Directive 2009/28/EC, both Ireland and the UK are required to have 16% and 15% respectively of their electricity generated by renewable sources by 2020. The projected impacts of climate change, population growth and urbanisation will place additional pressures on resources, further increasing future water demand which in turn will lead to higher energy consumption. Therefore, there is a need to achieve greater efficiencies across the water industry. The implementation of micro-hydropower turbines within the water supply network has shown considerable viability for energy recovery. This is achieved by harnessing energy at points of high flow or pressure along the network which can then be utilised on site or alternatively sold to the national grid. Micro-hydropower can provide greater energy security for utilities together with a reduction in greenhouse gas emissions. However, potential climate change impacts on water resources in the medium-to-long term currently act as a key barrier to industry confidence as changes in flow and pressure within the network can significantly alter the available energy for recovery. The present study aims to address these uncertainties and quantify the regional and local impacts of climate change on the viability of energy recovery across water infrastructure in Ireland and the UK. Specifically, the research focuses on assessing the potential future effects of climate change on flow rates at multiple pressure reducing valve sites along the water supply network and also in terms of flow at a number of wastewater

  2. The Ĝ Infrared Search for Extraterrestrial Civilizations with Large Energy Supplies. I. Background and Justification

    NASA Astrophysics Data System (ADS)

    Wright, J. T.; Mullan, B.; Sigurdsson, S.; Povich, M. S.

    2014-09-01

    We motivate the Ĝ infrared search for extraterrestrial civilizations with large energy supplies. We discuss some philosophical difficulties of the search for extraterrestrial intelligence (SETI), and how communication SETI circumvents them. We review "Dysonian SETI," the search for artifacts of alien civilizations, and find that it is highly complementary to traditional communication SETI; the two together might succeed where either one alone has not. We discuss the argument of Hart that spacefaring life in the Milky Way should be either galaxy-spanning or non-existent, and examine a portion of his argument that we call the "monocultural fallacy." We discuss some rebuttals to Hart that invoke sustainability and predict long Galaxy colonization timescales. We find that the maximum Galaxy colonization timescale is actually much shorter than previous work has found (<109 yr), and that many "sustainability" counter-arguments to Hart's thesis suffer from the monocultural fallacy. We extend Hart's argument to alien energy supplies and argue that detectably large energy supplies can plausibly be expected to exist because life has the potential for exponential growth until checked by resources or other limitations, and intelligence implies the ability to overcome such limitations. As such, if Hart's thesis is correct, then searches for large alien civilizations in other galaxies may be fruitful; if it is incorrect, then searches for civilizations within the Milky Way are more likely to succeed than Hart argued. We review some past Dysonian SETI efforts and discuss the promise of new mid-infrared surveys, such as that of WISE.

  3. A combined uninterruptible power supply and dynamic voltage compensator using a flywheel energy storage system

    NASA Astrophysics Data System (ADS)

    Weissbach, Robert Stephen

    Due to recent technological advances in materials, power electronics, magnetic bearings and controls, the flywheel energy storage system has become a viable alternative to electrochemical batteries. The advantages of the flywheel system are its higher power density, insensitivity to environmental conditions, lack of hazardous materials and ease of checking the charge. One potential use is in a power distribution system. The flywheel energy storage system may be used as both an uninterruptible power supply as well as a means of dynamic voltage compensation to protect critical loads on radial distribution feeders. To perform dynamic voltage compensation, a comparison was performed which shows that the series injection of power is preferable to the shunt injection of power in utilizing the available kVA of the flywheel system motor/generator. The system was designed and modeled using the Electromagnetic Transients Program to ensure a proper dynamic response of the flywheel energy storage system in either mode of operation. The design incorporates a boost converter on the dc link to enable the load voltage to be maintained as the flywheel spins down. The same boost converter also allows for extended operation in the series compensation mode, by implementing a novel control scheme where sinusoidal pulse width modulation control is used for to compensate for smaller supply voltage dips, while the boost converter is used to control the compensation for larger supply voltage dips.

  4. Sustainable global energy supply based on lignocellulosic biomass from afforestation of degraded areas.

    PubMed

    Metzger, Jürgen O; Hüttermann, Aloys

    2009-02-01

    An important aspect of present global energy scenarios is the assumption that the amount of biomass that can be grown on the available area is so limited that a scenario based on biomass as the major source of energy should be unrealistic. We have been investigating the question whether a Biomass Scenario may be realistic. We found that the global energy demand projected by the International Energy Agency in the Reference Scenario for the year 2030 could be provided sustainably and economically primarily from lignocellulosic biomass grown on areas which have been degraded by human activities in historical times. Moreover, other renewable energies will contribute to the energy mix. There would be no competition with increasing food demand for existing arable land. Afforestation of degraded areas and investment for energy and fuel usage of the biomass are not more expensive than investment in energy infrastructure necessary up to 2030 assumed in the fossil energy based Reference Scenario, probably much cheaper considering the additional advantages such as stopping the increase of and even slowly reducing the CO(2) content of the atmosphere, soil, and water conservation and desertification control. Most importantly, investment for a Biomass Scenario would be actually sustainable, in contrast to investment in energy-supply infrastructure of the Reference Scenario. Methods of afforestation of degraded areas, cultivation, and energetic usage of lignocellulosic biomass are available but have to be further improved. Afforestation can be started immediately, has an impact in some few years, and may be realized in some decades.

  5. Sustainable global energy supply based on lignocellulosic biomass from afforestation of degraded areas

    NASA Astrophysics Data System (ADS)

    Metzger, Jürgen O.; Hüttermann, Aloys

    2009-02-01

    An important aspect of present global energy scenarios is the assumption that the amount of biomass that can be grown on the available area is so limited that a scenario based on biomass as the major source of energy should be unrealistic. We have been investigating the question whether a Biomass Scenario may be realistic. We found that the global energy demand projected by the International Energy Agency in the Reference Scenario for the year 2030 could be provided sustainably and economically primarily from lignocellulosic biomass grown on areas which have been degraded by human activities in historical times. Moreover, other renewable energies will contribute to the energy mix. There would be no competition with increasing food demand for existing arable land. Afforestation of degraded areas and investment for energy and fuel usage of the biomass are not more expensive than investment in energy infrastructure necessary up to 2030 assumed in the fossil energy based Reference Scenario, probably much cheaper considering the additional advantages such as stopping the increase of and even slowly reducing the CO2 content of the atmosphere, soil, and water conservation and desertification control. Most importantly, investment for a Biomass Scenario would be actually sustainable, in contrast to investment in energy-supply infrastructure of the Reference Scenario. Methods of afforestation of degraded areas, cultivation, and energetic usage of lignocellulosic biomass are available but have to be further improved. Afforestation can be started immediately, has an impact in some few years, and may be realized in some decades.

  6. End User Functional and Performance Requirements for HTGR Energy Supply to Industrial Processes

    SciTech Connect

    L.E. Demick

    2010-09-01

    This document specifies end user functional and performance requirements to be used in the development of the design of a high temperature gas-cooled reactor (HTGR) based plant supplying energy to industrial processes. These requirements were developed from collaboration with industry and HTGR suppliers and from detailed evaluation of integration of the HTGR technology in industrial processes. The functional and performance requirements specified herein are an effective representation of the industrial sector energy needs and an effective basis for developing a plant design that will serve the broadest range of industrial applications.

  7. Energy metabolism and hindbrain AMPK: regulation by estradiol.

    PubMed

    Briski, Karen P; Ibrahim, Baher A; Tamrakar, Pratistha

    2014-03-01

    Nerve cell energy status is screened within multiple classically defined hypothalamic and hindbrain components of the energy balance control network, including the hindbrain dorsal vagal complex (DVC). Signals of caudal DVC origin have a physiological role in glucostasis, e.g., maintenance of optimal supply of the critical substrate fuel, glucose, through control of motor functions such as fuel consumption and gluco-counterregulatory hormone secretion. A2 noradrenergic neurons are a likely source of these signals as combinatory laser microdissection/high-sensitivity Western blotting reveals expression of multiple biomarkers for metabolic sensing, including adenosine 5'-monophosphate-activated protein kinase (AMPK). Hypoglycemia elicits estradiol-dependent sex differences in A2 AMPK activation as phospho-AMPK (pAMPK) expression is augmented in male and ovariectomized (OVX) female, but not estrogen-replaced, OVX rats. This dichotomy may reflect, in part, estradiol-mediated up-regulation of glycolytic and tricarboxylic acid cycle enzyme expression during hypoglycemia. Our new model for short-term feeding abstinence has physiological relevance to planned (dieting) or unplanned (meal delay) interruption of consumption in modern life, which is negatively correlated with appetite control and obesity, and is useful for investigating how estrogen may mitigate the effects of disrupted fuel acquisition on energy balance via actions within the DVC. Estradiol reduces DVC AMPK activity after local delivery of the AMP mimic, 5-aminoimidazole-4-carboxamide-riboside, or cessation of feeding for 12 h but elevates pAMPK expression when these treatments are combined. These data suggest that estrogen maintains cellular energy stability over periods of suspended fuel acquisition and yet optimizes, by DVC AMPK-dependent mechanisms, counter-regulatory responses to metabolic challenges that occur during short-span feeding abstinence.

  8. Geothermal Program Review XV: proceedings. Role of Research in the Changing World of Energy Supply

    SciTech Connect

    1997-01-01

    The U.S. Department of Energy`s Office of Geothermal Technologies conducted its annual Program Review XV in Berkeley, March 24-26, 1997. The geothermal community came together for an in-depth review of the federally-sponsored geothermal research and development program. This year`s theme focussed on {open_quotes}The Role of Research in the Changing World of Energy Supply.{close_quotes} This annual conference is designed to promote technology transfer by bringing together DOE-sponsored researchers; utility representatives; geothermal developers; equipment and service suppliers; representatives from local, state, and federal agencies; and others with an interest in geothermal energy. Separate abstracts have been indexed to the database for contributions to this conference.

  9. Neural Energy Supply-Consumption Properties Based on Hodgkin-Huxley Model.

    PubMed

    Wang, Yihong; Wang, Rubin; Xu, Xuying

    2017-01-01

    Electrical activity is the foundation of the neural system. Coding theories that describe neural electrical activity by the roles of action potential timing or frequency have been thoroughly studied. However, an alternative method to study coding questions is the energy method, which is more global and economical. In this study, we clearly defined and calculated neural energy supply and consumption based on the Hodgkin-Huxley model, during firing action potentials and subthreshold activities using ion-counting and power-integral model. Furthermore, we analyzed energy properties of each ion channel and found that, under the two circumstances, power synchronization of ion channels and energy utilization ratio have significant differences. This is particularly true of the energy utilization ratio, which can rise to above 100% during subthreshold activity, revealing an overdraft property of energy use. These findings demonstrate the distinct status of the energy properties during neuronal firings and subthreshold activities. Meanwhile, after introducing a synapse energy model, this research can be generalized to energy calculation of a neural network. This is potentially important for understanding the relationship between dynamical network activities and cognitive behaviors.

  10. Neural Energy Supply-Consumption Properties Based on Hodgkin-Huxley Model

    PubMed Central

    2017-01-01

    Electrical activity is the foundation of the neural system. Coding theories that describe neural electrical activity by the roles of action potential timing or frequency have been thoroughly studied. However, an alternative method to study coding questions is the energy method, which is more global and economical. In this study, we clearly defined and calculated neural energy supply and consumption based on the Hodgkin-Huxley model, during firing action potentials and subthreshold activities using ion-counting and power-integral model. Furthermore, we analyzed energy properties of each ion channel and found that, under the two circumstances, power synchronization of ion channels and energy utilization ratio have significant differences. This is particularly true of the energy utilization ratio, which can rise to above 100% during subthreshold activity, revealing an overdraft property of energy use. These findings demonstrate the distinct status of the energy properties during neuronal firings and subthreshold activities. Meanwhile, after introducing a synapse energy model, this research can be generalized to energy calculation of a neural network. This is potentially important for understanding the relationship between dynamical network activities and cognitive behaviors. PMID:28316842

  11. Comparison of Two Railgun Power Supply Architectures to Quantify the Energy Dissipated After the Projectile Leaves the Railgun

    DTIC Science & Technology

    2016-06-01

    post-fire energy 15. NUMBER OF PAGES 79 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT Unclassified 18. SECURITY CLASSIFICATION OF...RAILGUN POWER SUPPLY ARCHITECTURES TO QUANTIFY THE ENERGY DISSIPATED AFTER THE PROJECTILE LEAVES THE RAILGUN by Mitchell C. Stewart June...SUPPLY ARCHITECTURES TO QUANTIFY THE ENERGY DISSIPATED AFTER THE PROJECTILE LEAVES THE RAILGUN 5. FUNDING NUMBERS 6. AUTHOR(S) Mitchell C

  12. U.S. Wind Energy Manufacturing and Supply Chain: A Competitiveness Analysis

    SciTech Connect

    Fullenkamp, Patrick H; Holody, Diane S

    2014-06-15

    The goal of the project was to develop a greater understanding of the key factors determining wind energy component manufacturing costs and pricing on a global basis in order to enhance the competitiveness of U.S. manufacturers, and to reduce installed systems cost. Multiple stakeholders including DOE, turbine OEMs, and large component manufactures will all benefit by better understanding the factors determining domestic competitiveness in the emerging offshore and next generation land-based wind industries. Major objectives of this project were to: 1. Carry out global cost and process comparisons for 5MW jacket foundations, blades, towers, and permanent magnet generators; 2. Assess U.S. manufacturers’ competitiveness and potential for cost reduction; 3. Facilitate informed decision-making on investments in U.S. manufacturing; 4. Develop an industry scorecard representing the readiness of the U.S. manufacturers’ to produce components for the next generations of wind turbines, nominally 3MW land-based and 5MW offshore; 5. Disseminate results through the GLWN Wind Supply Chain GIS Map, a free website that is the most comprehensive public database of U.S. wind energy suppliers; 6. Identify areas and develop recommendations to DOE on potential R&D areas to target for increasing domestic manufacturing competitiveness, per DOE’s Clean Energy Manufacturing Initiative (CEMI). Lists of Deliverables 1. Cost Breakdown Competitive Analyses of four product categories: tower, jacket foundation, blade, and permanent magnet (PM) generator. The cost breakdown for each component includes a complete Bill of Materials with net weights; general process steps for labor; and burden adjusted by each manufacturer for their process categories of SGA (sales general and administrative), engineering, logistics cost to a common U.S. port, and profit. 2. Value Stream Map Competitiveness Analysis: A tool that illustrates both information and material flow from the point of getting a

  13. Effects of energy supply on leucine utilization by growing steers at two body weights.

    PubMed

    Schroeder, G F; Titgemeyer, E C; Moore, E S

    2007-12-01

    The effects of energy supplementation on Leu utilization in growing steers were evaluated in 2 experiments by using 6 ruminally cannulated Holstein steers. In Exp. 1, steers (initial BW = 150 +/- 7 kg) were limit-fed (2.3 kg of DM/d) a diet based on soybean hulls and received a basal ruminal infusion of 100 g of acetate/d, 75 g of propionate/d, and 75 g of butyrate/d, as well as abomasal infusions of 200 g of glucose/d and a mixture (215 g/d) containing all essential AA except Leu. Treatments were arranged as a 3 x 2 factorial, with 3 amounts of Leu infused abomasally (0, 4, and 8 g/d) and supplementation of diets with 2 amounts of energy (0 and 1.9 Mcal/d of GE). Supplemental energy was supplied by ruminal infusion of 100 g of acetate/ d, 75 g of propionate/d, and 75 g of butyrate/d, as well as abomasal infusion of 200 g of glucose/d to provide energy to the animal without affecting the microbial protein supply. When no supplemental energy was provided, Leu supplementation increased N balance, with no difference between 4 and 8 g/d of Leu (24.5, 27.0, and 27.3 g/d for 0, 4, and 8 g/d of Leu), but when additional energy was supplied, N retention increased linearly in response to Leu (25.6, 28.5, and 31.6 g/d for 0, 4, and 8 g/d of Leu; Leu x energy interaction, P = 0.06). The changes in N balance were the result of changes in urinary N excretion. The greater Leu retentions in response to energy supplementation when Leu was the most limiting nutrient indicate that energy supplementation improved the true efficiency of Leu utilization. In addition, supplemental energy increased the gross efficiency of Leu utilization when the Leu supply was not limiting by increasing the maximal rates of protein deposition. Experiment 2 was similar to Exp. 1, but steers had an initial BW of 275 +/- 12 kg and were limit-fed at 3.6 kg of DM/d. Retention of N was not affected (P = 0.22) by Leu supplementation, indicating that Leu did not limit protein deposition. Energy supply increased

  14. [Genetic variations in energy balance regulation].

    PubMed

    Pankov, Iu A

    2010-01-01

    Single nucleotide polymorphism (SNP) near certain genes revealed association of FAT(fat mass and obesity-associated gene), MC4R (melanocortin 4 receptor gene), and other genes with obesity. Participation of the FAT expression products in the regulation of energy balance remains to be clarified. The function of MC4R encoding melanocortin 4 receptor (MC4R) is somewhat better understood. alpha-, beta-, and gamma-MSH encoded by the POMC gene bind to MC4R, reduce food intake, and slow down fat accumulation. Expression of POMC that codes MSH is enhanced by leptin binding to the receptor (LepRb) in hypothalamic neurons. Mutations in human and animal MC4R, POMC, and LEP genes are known to be associated with obesity. More than 60 mutations in MC4R, more than 20 mutations in POMC and fewer LEP mutations have been reported. Nonsense mutations and reading frame shifts block gene expression and thereby disrupt protein synthesis. Missense mutations frequently affect protein folding in endoplasmic reticulum; unfolded or misfolded proteins remain in the cytoplasm and undergo degradation. Certain missence mutations do not interfere with gene expression and folding of proteins but impair their functioning at the periphery. P.S127L mutation in MC4R, p.E206X and p.F144L mutations in POMC as well as other mutations in homozygous and heterozygous forms account for disturbed energy balance in man. The LEP gene has been reported to contain G133fsX15, p.R105X, p.R1O5W, and p.S141C mutations. As a rule, they are associated with obesity and other pathological conditions only in homozygous forms.

  15. Global Regulation of Food Supply by Pseudomonas putida DOT-T1E▿ †

    PubMed Central

    Daniels, Craig; Godoy, Patricia; Duque, Estrella; Molina-Henares, M. Antonia; de la Torre, Jesús; del Arco, José María; Herrera, Carmen; Segura, Ana; Guazzaroni, M. Eugenia; Ferrer, Manuel; Ramos, Juan Luis

    2010-01-01

    Pseudomonas putida DOT-T1E was used as a model to develop a “phenomics” platform to investigate the ability of P. putida to grow using different carbon, nitrogen, and sulfur sources and in the presence of stress molecules. Results for growth of wild-type DOT-T1E on 90 different carbon sources revealed the existence of a number of previously uncharted catabolic pathways for compounds such as salicylate, quinate, phenylethanol, gallate, and hexanoate, among others. Subsequent screening on the subset of compounds on which wild-type DOT-TIE could grow with four knockout strains in the global regulatory genes Δcrc, Δcrp, ΔcyoB, and ΔptsN allowed analysis of the global response to nutrient supply and stress. The data revealed that most global regulator mutants could grow in a wide variety of substrates, indicating that metabolic fluxes are physiologically balanced. It was found that the Crc mutant did not differ much from the wild-type regarding the use of carbon sources. However, certain pathways are under the preferential control of one global regulator, i.e., metabolism of succinate and d-fructose is influenced by CyoB, and l-arginine is influenced by PtsN. Other pathways can be influenced by more than one global regulator; i.e., l-valine catabolism can be influenced by CyoB and Crp (cyclic AMP receptor protein) while phenylethylamine is affected by Crp, CyoB, and PtsN. These results emphasize the cross talk required in order to ensure proper growth and survival. With respect to N sources, DOT-T1E can use a wide variety of inorganic and organic nitrogen sources. As with the carbon sources, more than one global regulator affected growth with some nitrogen sources; for instance, growth with nucleotides, dipeptides, d-amino acids, and ethanolamine is influenced by Crp, CyoB, and PtsN. A surprising finding was that the Crp mutant was unable to flourish on ammonium. Results for assayed sulfur sources revealed that CyoB controls multiple points in methionine

  16. The AMPK/SNF1/SnRK1 fuel gauge and energy regulator: structure, function and regulation.

    PubMed

    Ghillebert, Ruben; Swinnen, Erwin; Wen, Jing; Vandesteene, Lies; Ramon, Matthew; Norga, Koen; Rolland, Filip; Winderickx, Joris

    2011-11-01

    All life forms on earth require a continuous input and monitoring of carbon and energy supplies. The AMP-activated kinase (AMPK)/sucrose non-fermenting1 (SNF1)/Snf1-related kinase1 (SnRK1) protein kinases are evolutionarily conserved metabolic sensors found in all eukaryotic organisms from simple unicellular fungi (yeast SNF1) to animals (AMPK) and plants (SnRK1). Activated by starvation and energy-depleting stress conditions, they enable energy homeostasis and survival by up-regulating energy-conserving and energy-producing catabolic processes, and by limiting energy-consuming anabolic metabolism. In addition, they control normal growth and development as well as metabolic homeostasis at the organismal level. As such, the AMPK/SNF1/SnRK1 kinases act in concert with other central signaling components to control carbohydrate uptake and metabolism, fatty acid and lipid biosynthesis and the storage of carbon energy reserves. Moreover, they have a tremendous impact on developmental processes that are triggered by environmental changes such as nutrient depletion or stress. Although intensive research by many groups has partly unveiled the factors that regulate AMPK/SNF1/SnRK1 kinase activity as well as the pathways and substrates they control, several fundamental issues still await to be clarified. In this review, we will highlight these issues and focus on the structure, function and regulation of the AMPK/SNF1/SnRK1 kinases.

  17. Effect of improved hydrogen supply on energy state, ureogenesis and gluconeogenesis in isolated hepatocytes.

    PubMed

    Letko, G; Halangk, W

    1986-01-01

    The cellular energy state as well as ureogenesis and gluconeogenesis as ATP-consuming processes were studied as a function of hydrogen supply of mitochondria in isolated hepatocytes. Even though the ATP turnover was quite different during ureogenesis and gluconeogenesis and in the absence of these syntheses both the safranine signals (as a probe for the mitochondrial membrane potential) and the total ATP contents of the cells did not vary to a great extent. Partial uncoupling by FCCP destroyed the mitochondrial membrane potential and decreased the cellular ATP totally. Under these conditions the presence of ornithine plus lactate maintained a measurable membrane potential and ATP level. In order to demonstrate the relevance of hydrogen supply of mitochondria to the syntheses of glucose and urea, the load on energy metabolism was additionally increased by partial uncoupling, and the cells were incubated in a parallel mode in Krebs-Henseleit buffer and an 80 mM succinate containing medium, the latter forcing succinate into the cells. After partial uncoupling, ureogenesis and gluconeogenesis as well as the ATP level were seen to decrease markedly in Krebs-Henseleit buffer, whereas in the succinate medium the improved hydrogen supply of mitochondria counteracted the drain by FCCP, and substantially higher rates of the syntheses and elevated ATP levels were maintained.

  18. Energy Levels and Co-evolution of Product Innovation in Supply Chain Clusters

    NASA Astrophysics Data System (ADS)

    Ji, Guojun

    In the last decade supply chain clusters phenomenon has emerged as a new approach in product innovation studies. This article makes three contributions to the approach by addressing some open issues. The first contribution is to explicitly incorporate the energy levels in the analysis. Hence, the unit of analysis is widened from sectoral systems of innovation to socio-technical systems. Hence, the unit of analysis is widened from sectoral systems of innovation to socio-technical systems. The second contribution is to suggest an analytical distinction between different evolution method, actors involved in them, and the institutions which guide actor's perceptions and activities. Thirdly, the article opens up the black box of institutions, making them an integral part of supply chain. The article provides a coherent conceptual multi-level perspective, using insights from sociology, institutional theory and innovation studies. The perspective is particularly useful to analyze long-term dynamics supply chain clusters phenomenon, shifts from one energy level to another and the co-evolution of product innovation.

  19. 78 FR 69267 - Defense Federal Acquisition Regulation Supplement: Requirements Relating to Supply Chain Risk...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-18

    ... supply chain risk. This rule implements section 806's three supply-chain risk-management approaches as... to improve supply chain risk management (SCRM). In doing so, the DoDI requires, among other things... consider the impact of supply chain risk in specified types of procurements related to national...

  20. Sudden Clearing of Estuarine Waters upon Crossing the Threshold from Transport to Supply Regulation of Sediment Transport as an Erodible Sediment Pool is Depleted: San Francisco Bay, 1999

    USGS Publications Warehouse

    Schoellhamer, D.H.

    2011-01-01

    The quantity of suspended sediment in an estuary is regulated either by transport, where energy or time needed to suspend sediment is limiting, or by supply, where the quantity of erodible sediment is limiting. This paper presents a hypothesis that suspended-sediment concentration (SSC) in estuaries can suddenly decrease when the threshold from transport to supply regulation is crossed as an erodible sediment pool is depleted. This study was motivated by a statistically significant 36% step decrease in SSC in San Francisco Bay from water years 1991-1998 to 1999-2007. A quantitative conceptual model of an estuary with an erodible sediment pool and transport or supply regulation of sediment transport is developed. Model results confirm that, if the regulation threshold was crossed in 1999, SSC would decrease rapidly after water year 1999 as observed. Estuaries with a similar history of a depositional sediment pulse followed by erosion may experience sudden clearing. ?? 2011 Coastal and Estuarine Research Federation (outside the USA).

  1. A Preliminary Analysis of the Economics of Using Distributed Energy as a Source of Reactive Power Supply

    SciTech Connect

    Li, Fangxing; Kueck, John D; Rizy, D Tom; King, Thomas F

    2006-04-01

    A major blackout affecting 50 million people in the Northeast United States, where insufficient reactive power supply was an issue, and an increased number of filings made to the Federal Energy Regulatory Commission by generators for reactive power has led to a closer look at reactive power supply and compensation. The Northeastern Massachusetts region is one such area where there is an insufficiency in reactive power compensation. Distributed energy due to its close proximity to loads seems to be a viable option for solving any present or future reactive power shortage problems. Industry experts believe that supplying reactive power from synchronized distributed energy sources can be 2 to 3 times more effective than providing reactive support in bulk from longer distances at the transmission or generation level. Several technology options are available to supply reactive power from distributed energy sources such as small generators, synchronous condensers, fuel cells or microturbines. In addition, simple payback analysis indicates that investments in DG to provide reactive power can be recouped in less than 5 years when capacity payments for providing reactive power are larger than $5,000/kVAR and the DG capital and installation costs are lower than $30/kVAR. However, the current institutional arrangements for reactive power compensation present a significant barrier to wider adoption of distributed energy as a source of reactive power. Furthermore, there is a significant difference between how generators and transmission owners/providers are compensated for reactive power supplied. The situation for distributed energy sources is even more difficult, as there are no arrangements to compensate independent DE owners interested in supplying reactive power to the grid other than those for very large IPPs. There are comparable functionality barriers as well, as these smaller devices do not have the control and communications requirements necessary for automatic

  2. Energy Costs of Urban Water Supply Systems: Evidence from India (Invited)

    NASA Astrophysics Data System (ADS)

    Malghan, D.; Mehta, V. K.; Goswami, R.

    2013-12-01

    For the first time in human history more people around the globe now live in urban centres rather than in rural settings. Although India's urban population proportion at 31% is still below the global average, it has been urbanizing rapidly. The population growth rate in urban India is more than two-and-half times that of rural India. The current Indian urban population, of over 370 million people, exceeds that of the total population of every other country on the planet with the exception of China. Supplying water to India's burgeoning urban agglomerations poses a challenge in terms of social equity, biophysical sustainability, and economic efficiency. A typical Indian city relies on both surface and ground water sources. Several Indian cities import surface water from distances that now exceed a hundred kilometres and across gradients of up to three thousand metres. While the depleting groundwater levels as a result of rapidly growing demand from urban India is at least anecdotally understood even when reliable estimates are not available, the energy costs of supplying water to urban India has thus far not received academic or policy attention it deserves. We develop a simple framework to integrate distributed groundwater models with water consumption data to estimate the energy and emissions associated with supplying water to urban centres. We assemble a unique data set from seventy five of the largest urban agglomerations in India and derive estimated values of energy consumption and carbon emissions associated with water provision in urban India. Our analysis shows that in every major city, the energy cost associated with long distance import of surface water significantly exceeds groundwater extraction. However, with rapidly depleting groundwater levels, we estimate inflection points for select cities when energy costs of groundwater extraction will exceed energy required to import surface water into the city. In addition to the national snapshot, we also

  3. Motor protein traffic regulation by supply-demand balance of resources

    NASA Astrophysics Data System (ADS)

    Ciandrini, Luca; Neri, Izaak; Walter, Jean Charles; Dauloudet, Olivier; Parmeggiani, Andrea

    2014-10-01

    In cells and in in vitro assays the number of motor proteins involved in biological transport processes is far from being unlimited. The cytoskeletal binding sites are in contact with the same finite reservoir of motors (either the cytosol or the flow chamber) and hence compete for recruiting the available motors, potentially depleting the reservoir and affecting cytoskeletal transport. In this work we provide a theoretical framework in which to study, analytically and numerically, how motor density profiles and crowding along cytoskeletal filaments depend on the competition of motors for their binding sites. We propose two models in which finite processive motor proteins actively advance along cytoskeletal filaments and are continuously exchanged with the motor pool. We first look at homogeneous reservoirs and then examine the effects of free motor diffusion in the surrounding medium. We consider as a reference situation recent in vitro experimental setups of kinesin-8 motors binding and moving along microtubule filaments in a flow chamber. We investigate how the crowding of linear motor proteins moving on a filament can be regulated by the balance between supply (concentration of motor proteins in the flow chamber) and demand (total number of polymerized tubulin heterodimers). We present analytical results for the density profiles of bound motors and the reservoir depletion, and propose novel phase diagrams that present the formation of jams of motor proteins on the filament as a function of two tuneable experimental parameters: the motor protein concentration and the concentration of tubulins polymerized into cytoskeletal filaments. Extensive numerical simulations corroborate the analytical results for parameters in the experimental range and also address the effects of diffusion of motor proteins in the reservoir. We then propose experiments for validating our models and discuss how the ‘supply-demand’ effects can regulate motor traffic also in in vivo

  4. Investigations of DC power supplies with optoelectronic transducers and RF energy converters

    NASA Astrophysics Data System (ADS)

    Guzowski, B.; Gozdur, R.; Bernacki, L.; Lakomski, M.

    2016-04-01

    Fiber Distribution Cabinets (FDC) monitoring systems are increasingly popular. However it is difficult to realize such system in passive FDC, due to lack of source of power supply. In this paper investigation of four different DC power supplies with optoelectronic transducers is described. Two converters: photovoltaic power converter and PIN photodiode can convert the light transmitted through the optical fiber to electric energy. Solar cell and antenna RF-PCB are also tested. Results presented in this paper clearly demonstrate that it is possible to build monitoring system in passive FDC. During the tests maximum obtained output power was 11 mW. However all converters provided enough power to excite 32-bit microcontroller with ARM-cores and digital thermometer.

  5. Modulation of energy and protein supplies in sequential feeding in laying hens.

    PubMed

    Traineau, M; Bouvarel, I; Mulsant, C; Roffidal, L; Launay, C; Lescoat, P

    2015-01-01

    Sequential feeding (SF) consists of splitting energy (E) and protein/calcium (P) fractions temporally, improving the feed conversion ratio (FCR) of hens compared with a continuous distribution during the day. In a previous study, the E fraction (with a low level of protein) was provided in the morning, whereas the P fraction (with low level of energy) was given in the afternoon. However, there is no clear evidence that a requirement in energy or proteins is connected to these distribution sequences, whereas the requirement for calcium is known to be required in the afternoon. To evaluate the effects on performances of the modulation of energy and protein supplies in SF, five different sequential treatments were offered: E0P0/E0P0; E+P+/E-P-; E+P-/E-P+; E0P+/E0P- and E+P0/E-P0 where E+ represents a high energy level, E0 a moderate one and E- a low one (with the same meaning for P regarding protein supply). Afternoon fractions were provided with particulate calcium. A total of 168 Hendrix hens were housed in individual cages from 20 to 39 weeks of age in two environmentally contrasted rooms. Feed intake in the morning and afternoon fractions, egg production, egg weight, BW and weight of digestive organs were recorded. No diet effect was observed concerning feed intake, egg production and BW. These results suggested that hens are not able to fit their feed intake on energy or protein level of fractions within half-day duration, whereas at the day scale same protein and energy intakes were observed. Moreover, the time of nutrient distribution in feeding did not seem to have an impact on birds' performances. These studies have also demonstrated that, despite strong environmental pressure, the hens with SF had attenuated performance but continue to produce eggs.

  6. A simple metabolic model of glacial-interglacial energy supply to the upper ocean

    NASA Astrophysics Data System (ADS)

    Pelegrí, J. L.; Olivella, R.; García-Olivares, A.

    2011-03-01

    We use a simple two-state two-box ocean to simulate the CO2 signal during the last four glacial-interglacial transitions in the earth system. The model is inspired by the similarity in spatial organization and temporal transition patterns between the earth and other complex systems, such as mammals. The comparison identifies the earth's metabolic rate with net autotrophic primary production in the upper ocean, sustained through new inorganic carbon and nutrients advected from the deep ocean and organic matter remineralized within the upper ocean. We view the glacial-interglacial transition as a switch of the upper ocean from a basal to an enhanced metabolic state, with energy supply initially relying on the remineralization of the local organic sources and the eventual steady state resulting from the increased advective supply of inorganic deep sources. During the interglacial-glacial transition the opposite occurs, with an initial excess of advective supply and primary production that allows the replenishment of the upper-ocean organic storages. We set the relative change in energy supply from the CO2 signal and use genetic algorithms to explore the sensitivity of the model output to both the basal recirculation rate and the intensity-timing of the maximum recirculation rate. The model is capable of reproducing quite well the long-term oscillations, as shown by correlations with observations typically about 0.8. The dominant time scale for each cycle ranges between about 40 and 45 kyr, close to the 41 kyr average obliquity astronomical period, and the deep-ocean recirculation rate increases between one and two orders of magnitude from glacial to interglacial periods.

  7. [Assessment of energy metabolism and nutritional supply in children with mechanical ventilation].

    PubMed

    Ji, Jian; Qian, Suyun; Yan, Jie

    2016-01-01

    To determine the resting energy expenditure on mechanical ventilation in pediatric intensive care unit (PICU) by indirect calorimetry, and analyze the distribution of metabolic states. The nutrition supply was assessed according to the resting energy expenditure. An observational study which was held in PICU of Beijing Children's Hospital from November 2013 to April 2014. Critically ill children with mechanical ventilation were enrolled in this study. The inclusion criteria included the following: (1) pediatric critical illness score < 90, or meet the United States PICU admission criteria; (2) age > 29 days, < 18 years old; (3) time of mechanical ventilation > 24 hours; (4) volume of mechanical ventilation > 60 ml. Resting energy expenditure was determined by US Med Graphic Company CCM/D energy metabolism test system. Predictive resting energy expenditure was calculated for each subject with age-appropriate equation (Schofield-HTWT). According to the actual energy intake records and required energy intake (10% higher than the measured value) to define the nutritional status. The selected subjects were grouped according to gender, age, types of disease and nutritional status, and compared the metabolic status and nutritional supply of different groups. Sixty-eight children were enrolled in this study, 46 were boys and 22 were girls, including 25 cases of pneumonia with respiratory failure, 23 cases of central nervous system diseases complicated with respiratory failure and 20 cases of postoperative tracheal intubation. The ratio of boys and girls was 2:1. The results showed 36 patients in a low metabolic state, accounting for 53%, 23 patients in a high metabolic state, accounting for 34% and 9 patients (13%) in the metabolism of the normal state. In the male children, 12 cases (26%) were in the high metabolism and 26 cases (57%) were in the low metabolism, and 8 cases (17%) were in the normal metabolism. In the female children, 11 cases (50%) were classified into

  8. Temperature conditions and heat supply of apartments in an apartment house with individual regulators

    NASA Astrophysics Data System (ADS)

    Danilevskii, L. N.

    2011-03-01

    This paper presents the results of mathematical modeling of the values of the temperature and the heat source power in apartments of an apartment house with individual regulators. It has been shown that for the existing structures of buildings the heat transfer between apartments with individual thermoregulation strongly influences the values of the heat source power established in apartments in the process of regulation. Without changing the total heating load of the building, this process leads to considerable deviations of readings of the thermal energy meters in apartments from the thermal energy actually consumed for their heating. This fact throws doubt upon the expediency of installing individual calorimeters in an apartment house with thermoregulation in each apartment.

  9. Mapping medical marijuana: state laws regulating patients, product safety, supply chains and dispensaries, 2017.

    PubMed

    Klieger, Sarah B; Gutman, Abraham; Allen, Leslie; Pacula, Rosalie Liccardo; Ibrahim, Jennifer K; Burris, Scott

    2017-07-11

    (1) To describe open source legal data sets, created for research use, that capture the key provisions of US state medical marijuana laws. The data document how state lawmakers have regulated a medicine that remains, under federal law, a Schedule I illegal drug with no legitimate medical use. (2) To demonstrate the variability that exists across states in rules governing patient access, product safety and dispensary practice. Two legal researchers collected and coded state laws governing marijuana patients, product safety and dispensaries in effect on 1 February 2017, creating three empirical legal data sets. We used summary tables to identify the variation in specific statutory provisions specified in each state's medical marijuana law as it existed on 1 February 2017. We compared aspects of these laws to the traditional Federal approach to regulating medicine. Full data sets, codebooks and protocols are available through the Prescription Drug Abuse Policy System (http://www.pdaps.org/; Archived at http://www.webcitation.org/6qv5CZNaZ on 2 June 2017). Twenty-eight states (including the District of Columbia) have authorized medical marijuana. Twenty-seven specify qualifying diseases, which differ across states. All states protect patient privacy; only 14 protect patients against discrimination. Eighteen states have mandatory product safety testing before any sale. While the majority have package/label regulations, states have a wide range of specific requirements. Most regulate dispensaries (25 states), with considerable variation in specific provisions such as permitted product supply sources number of dispensaries per state and restricting proximity to various types of location. The federal ban in the United States on marijuana has resulted in a patchwork of regulatory strategies that are not uniformly consistent with the approach usually taken by the Federal government and whose effectiveness remains unknown. © 2017 Society for the Study of Addiction.

  10. Energy supply and environmental issues: The Los Alamos National Laboratory experience in regional and international programs

    SciTech Connect

    Goff, S.J.

    1995-12-31

    The Los Alamos National Laboratory, operated by the University of California, encompasses more than forty-three square miles of mesas and canyons in northern New Mexico. A Department of Energy national laboratory, Los Alamos is one of the largest multidisciplinary, multiprogram laboratories in the world. Our mission, to apply science and engineering capabilities to problems of national security, has expanded to include a broad array of programs. We conduct extensive research in energy, nuclear safeguards and security, biomedical science, computational science, environmental protection and cleanup, materials science, and other basic sciences. The Energy Technology Programs Office is responsible for overseeing and developing programs in three strategic areas: energy systems and the environment, transportation and infrastructure, and integrated chemicals and materials processing. Our programs focus on developing reliable, economic and environmentally sound technologies that can help ensure an adequate supply of energy for the nation. To meet these needs, we are involved in programs that range from new and enhanced oil recovery technologies and tapping renewable energy sources, through efforts in industrial processes, electric power systems, clean coal technologies, civilian radioactive waste, high temperature superconductivity, to studying the environmental effects of energy use.

  11. An increase in the efficiency of heat supply systems on reconstruction of energy sources and modernization of gas supply systems

    NASA Astrophysics Data System (ADS)

    Kolegov, Yu. Ye.; Stennikov, N. V.; Fedyaev, A. V.

    2012-04-01

    The present paper deals with technical and economic problems related to an increase in the efficiency of the use of natural gas on reconstruction of the hest supply systems in the urban-type settlement of Nogliki, with the use of combined heat and power production at the local gas-turbine-based power plant.

  12. Wind-powered asynchronous AC/DC/AC converter system. [for electric power supply regulation

    NASA Technical Reports Server (NTRS)

    Reitan, D. K.

    1973-01-01

    Two asynchronous ac/dc/ac systems are modelled that utilize wind power to drive a variable or constant hertz alternator. The first system employs a high power 60-hertz inverter tie to the large backup supply of the power company to either supplement them from wind energy, storage, or from a combination of both at a preset desired current; rectifier and inverter are identical and operate in either mode depending on the silicon control rectifier firing angle. The second system employs the same rectification but from a 60-hertz alternator arrangement; it provides mainly dc output, some sinusoidal 60-hertz from the wind bus and some high harmonic content 60-hertz from an 800-watt inverter.

  13. Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply.

    PubMed Central

    Sugden, M C; Langdown, M L; Harris, R A; Holness, M J

    2000-01-01

    Activation of the pyruvate dehydrogenase (PDH) complex (PDHC) promotes glucose disposal, whereas inactivation conserves glucose. The PDH kinases (PDHKs) regulate glucose oxidation through inhibitory phosphorylation of PDHC. The adult rat heart contains three PDHK isoforms PDHK1, PDHK2 and PDHK4. Using Western-blot analysis, with specific antibodies raised against individual recombinant PDHK1, PDHK2 and PDHK4, the present study investigated PDHK isoform expression in the developing rat heart and adulthood. We identified clear differences in the patterns of protein expression of each of these PDHK isoforms during the first 3 weeks of post-natal development, with most marked up-regulation of isoforms PDHK1 and PDHK4. Distinctions between the three cardiac PDHK isoforms were also demonstrated with respect to post-neonatal maturational up-regulation; with greatest up-regulation of PDHK1 and least up-regulation of PDHK4 from the post-neonatal period until maturity. The study also examined the role of thyroid hormone status and lipid supply on PDHK isoform expression. We observed marked selective increases in the amount of PDHK4 protein present relative to total cardiac protein in both hyperthyroidism and high-fat feeding. Overall, our data identify PDHK isoform PDHK1 as being of more potential regulatory importance for glucose oxidation in the adult compared with the neonatal heart, and cardiac PDHK4 as a PDHK isoform whose expression is specifically responsive to changes in lipid supply, suggesting that its up-regulation during early post-natal life may be the perinatal switch to use fatty acids as the energy source. We also identify regulation of pyruvate sensitivity of cardiac PDHK as a physiological variable, a change in which requires factors in addition to a change in lipid supply. PMID:11104680

  14. On Maximizing the Lifetime of Wireless Sensor Networks by Optimally Assigning Energy Supplies

    PubMed Central

    Asorey-Cacheda, Rafael; García-Sánchez, Antonio Javier; García-Sánchez, Felipe; García-Haro, Joan; Gonzalez-Castaño, Francisco Javier

    2013-01-01

    The extension of the network lifetime of Wireless Sensor Networks (WSN) is an important issue that has not been appropriately solved yet. This paper addresses this concern and proposes some techniques to plan an arbitrary WSN. To this end, we suggest a hierarchical network architecture, similar to realistic scenarios, where nodes with renewable energy sources (denoted as primary nodes) carry out most message delivery tasks, and nodes equipped with conventional chemical batteries (denoted as secondary nodes) are those with less communication demands. The key design issue of this network architecture is the development of a new optimization framework to calculate the optimal assignment of renewable energy supplies (primary node assignment) to maximize network lifetime, obtaining the minimum number of energy supplies and their node assignment. We also conduct a second optimization step to additionally minimize the number of packet hops between the source and the sink. In this work, we present an algorithm that approaches the results of the optimization framework, but with much faster execution speed, which is a good alternative for large-scale WSN networks. Finally, the network model, the optimization process and the designed algorithm are further evaluated and validated by means of computer simulation under realistic conditions. The results obtained are discussed comparatively. PMID:23939582

  15. On maximizing the lifetime of Wireless Sensor Networks by optimally assigning energy supplies.

    PubMed

    Asorey-Cacheda, Rafael; García-Sánchez, Antonio Javier; García-Sánchez, Felipe; García-Haro, Joan; González-Castano, Francisco Javier

    2013-08-09

    The extension of the network lifetime of Wireless Sensor Networks (WSN) is an important issue that has not been appropriately solved yet. This paper addresses this concern and proposes some techniques to plan an arbitrary WSN. To this end, we suggest a hierarchical network architecture, similar to realistic scenarios, where nodes with renewable energy sources (denoted as primary nodes) carry out most message delivery tasks, and nodes equipped with conventional chemical batteries (denoted as secondary nodes) are those with less communication demands. The key design issue of this network architecture is the development of a new optimization framework to calculate the optimal assignment of renewable energy supplies (primary node assignment) to maximize network lifetime, obtaining the minimum number of energy supplies and their node assignment. We also conduct a second optimization step to additionally minimize the number of packet hops between the source and the sink. In this work, we present an algorithm that approaches the results of the optimization framework, but with much faster execution speed, which is a good alternative for large-scale WSN networks. Finally, the network model, the optimization process and the designed algorithm are further evaluated and validated by means of computer simulation under realistic conditions. The results obtained are discussed comparatively.

  16. The Ĝ infrared search for extraterrestrial civilizations with large energy supplies. I. Background and justification

    SciTech Connect

    Wright, J. T.; Mullan, B.; Sigurdsson, S.; Povich, M. S.

    2014-09-01

    We motivate the Ĝ infrared search for extraterrestrial civilizations with large energy supplies. We discuss some philosophical difficulties of the search for extraterrestrial intelligence (SETI), and how communication SETI circumvents them. We review 'Dysonian SETI', the search for artifacts of alien civilizations, and find that it is highly complementary to traditional communication SETI; the two together might succeed where either one alone has not. We discuss the argument of Hart that spacefaring life in the Milky Way should be either galaxy-spanning or non-existent, and examine a portion of his argument that we call the 'monocultural fallacy'. We discuss some rebuttals to Hart that invoke sustainability and predict long Galaxy colonization timescales. We find that the maximum Galaxy colonization timescale is actually much shorter than previous work has found (<10{sup 9} yr), and that many 'sustainability' counter-arguments to Hart's thesis suffer from the monocultural fallacy. We extend Hart's argument to alien energy supplies and argue that detectably large energy supplies can plausibly be expected to exist because life has the potential for exponential growth until checked by resources or other limitations, and intelligence implies the ability to overcome such limitations. As such, if Hart's thesis is correct, then searches for large alien civilizations in other galaxies may be fruitful; if it is incorrect, then searches for civilizations within the Milky Way are more likely to succeed than Hart argued. We review some past Dysonian SETI efforts and discuss the promise of new mid-infrared surveys, such as that of WISE.

  17. An investigation into the relationship between metabolic responses and energy regulation in antibody-producing cell.

    PubMed

    Sun, Ya-Ting; Zhao, Liang; Ye, Zhao-Yang; Fan, Li; Liu, Xu-Ping; Tan, Wen-Song

    2013-11-28

    Energy-efficient metabolic responses were often noted in high-productive cultures. To better understand these metabolic responses, an investigation into the relationship between metabolic responses and energy regulation was conducted via a comparative analysis among cultures with different energy source supplies. Both glycolysis and glutaminolysis were studied through the kinetic analyses of major extracellular metabolites concerning the fast and slow cell growth stages, respectively, as well as the time-course profiles of intracellular metabolites. In three cultures showing distinct antibody productivities, the amino acid metabolism and energy state were further examined. Both the transition of lactate from production to consumption and steady intracellular pools of pyruvate and lactate were observed to be correlated with efficient energy regulation. In addition, an efficient utilization of amino acids as the replenishment for the TCA cycle was also found in the cultures with upregulated energy metabolism. It was further revealed that the inefficient energy regulation would cause low cell productivity based on the comparative analysis of cell growth and productivity in cultures having distinct energy regulation.

  18. Geothermal energy and the utility market -- the opportunities and challenges for expanding geothermal energy in a competitive supply market: Proceedings

    SciTech Connect

    Not Available

    1992-01-01

    Each year the Geothermal Division of the US Department of Energy conducts an in-depth review of its entire geothermal R D program. The conference serves several purposes: a status report on current R D activities, an assessment of progress and problems, a review of management issues, and a technology transfer opportunity between DOE and the US geothermal city. This year's conference, Program Review X, was held in San Francisco on March 24--26, 1992. The theme of the review, Geothermal Energy and the Utility Market -- The Opportunities and Challenges for Expanding Geothermal Energy in a Competitive Supply Market,'' focused on the needs of the electric utility sector. Geothermal energy, with its power capacity potential of 10 GWe by the year 2010, can provide reliable, enviromentally clean electricity which can help offset the projected increase in demand. Program Review X consisted of seven sessions including an opening session with presentations by Mr. Vikram Budhraja, Vice President of System Planning and Operations, Southern California Edison Company, and Mr. Richard Jaros, President and Chief Operating Officer, California Energy Company. The six technical sessions included presentations by the relevant field researchers covering DOE-sponsored R D in hydrothermal, hot dry rock, and geopressured energy. Individual projects are processed separately for the data bases.

  19. American Security and the International Energy Situation. Volume 2. World Energy and the Security of Supply

    DTIC Science & Technology

    1975-04-15

    Leontlef, Peck, Samuelson and Solow . The stbtement, titled "Oil Shortages and Middle East Politics," was reproduced in its entirely ir The Energy... Daniel Ellsberg’s study on "The Art and Practice of Blackmail" (mimeo., 1950) helps to Illuminate this tendency to ascribe success to the oil weapon by

  20. The General Evolving Model for Energy Supply-Demand Network with Local-World

    NASA Astrophysics Data System (ADS)

    Sun, Mei; Han, Dun; Li, Dandan; Fang, Cuicui

    2013-10-01

    In this paper, two general bipartite network evolving models for energy supply-demand network with local-world are proposed. The node weight distribution, the "shifting coefficient" and the scaling exponent of two different kinds of nodes are presented by the mean-field theory. The numerical results of the node weight distribution and the edge weight distribution are also investigated. The production's shifted power law (SPL) distribution of coal enterprises and the installed capacity's distribution of power plants in the US are obtained from the empirical analysis. Numerical simulations and empirical results are given to verify the theoretical results.

  1. The sustainable water-energy nexus: Life-cycle impacts and feasibility of regional energy and water supply scenarios

    NASA Astrophysics Data System (ADS)

    Dale, Alexander T.

    Water and energy are critical, interdependent, and regional resources, and effective planning and policies around which sources to use requires combining information on environmental impacts, cost, and availability. Questions around shifting energy and water sources towards more renewable options, as well as the potential role of natural gas from shale formations are under intense discussion. Decisions on these issues will be made in the shadow of climate change, which will both impact and be impacted by energy and water supplies. This work developed a model for calculating the life-cycle environmental impacts of regional energy and water supply scenarios (REWSS). The model was used to discuss future energy pathways in Pennsylvania, future electricity impacts in Brazil, and future water pathways in Arizona. To examine energy in Pennsylvania, this work also developed the first process-based life-cycle assessment (LCA) of shale gas, focusing on greenhouse gas (GHG) emissions, energy consumption, and water consumption. This LCA confirmed results that shale gas is similar to conventional gas in GHG emissions, though potentially has a lower net energy due to a wide range of production rates for wells. Brazil's electricity-related impacts will rise as development continues. GHG emissions are shown to double by 2020 due to expanded natural gas (NG) and coal usage, with a rise of 390% by 2040 posssible with tropical hydropower reservoirs. While uncertainty around reservoir impacts is large, Brazil's low GHG emissions intensity and future carbon emissions targets are threatened by likely electricity scenarios. Pennsylvania's energy-related impacts are likely to hinge on whether NG is used as a replacement for coal, allowing GHG emissions to drop and then plateau at 93% of 2010 values; or as a transition fuel to expanded renewable energy sources, showing a steady decrease to 86% in 2035. Increased use of biofuels will dominate land occupation and may dominate water

  2. Decentralized control of units in smart grids for the support of renewable energy supply

    SciTech Connect

    Sonnenschein, Michael; Lünsdorf, Ontje; Bremer, Jörg; Tröschel, Martin

    2015-04-15

    Due to the significant environmental impact of power production from fossil fuels and nuclear fission, future energy systems will increasingly rely on distributed and renewable energy sources (RES). The electrical feed-in from photovoltaic (PV) systems and wind energy converters (WEC) varies greatly both over short and long time periods (from minutes to seasons), and (not only) by this effect the supply of electrical power from RES and the demand for electrical power are not per se matching. In addition, with a growing share of generation capacity especially in distribution grids, the top-down paradigm of electricity distribution is gradually replaced by a bottom-up power supply. This altogether leads to new problems regarding the safe and reliable operation of power grids. In order to address these challenges, the notion of Smart Grids has been introduced. The inherent flexibilities, i.e. the set of feasible power schedules, of distributed power units have to be controlled in order to support demand–supply matching as well as stable grid operation. Controllable power units are e.g. combined heat and power plants, power storage systems such as batteries, and flexible power consumers such as heat pumps. By controlling the flexibilities of these units we are particularly able to optimize the local utilization of RES feed-in in a given power grid by integrating both supply and demand management measures with special respect to the electrical infrastructure. In this context, decentralized systems, autonomous agents and the concept of self-organizing systems will become key elements of the ICT based control of power units. In this contribution, we first show how a decentralized load management system for battery charging/discharging of electrical vehicles (EVs) can increase the locally used share of supply from PV systems in a low voltage grid. For a reliable demand side management of large sets of appliances, dynamic clustering of these appliances into uniformly

  3. Production and supply of radioisotopes with high-energy particle accelerators current status and future directions

    SciTech Connect

    Srivastava, S.C.; Mausner, L.F.

    1994-03-01

    Although the production of radioisotopes in reactors or in low to medium energy cyclotrons appears to be relatively well established, especially for those isotopes that are routinely used and have a commercial market, certain isotopes can either be made only in high-energy particle accelerators or their production is more cost effective when made this way. These facilities are extremely expensive to build and operate, and isotope production is, in general, either not cost-effective or is in conflict with their primary mandate or missions which involve physics research. Isotope production using high-energy accelerators in the US, therefore, has been only an intermittent and parasitic activity. However, since a number of isotopes produced at higher energies are emerging as being potentially useful for medical and other applications, there is a renewed concern about their availability in a continuous and reliable fashion. In the US, in particular, the various aspects of the prediction and availability of radioisotopes from high-energy accelerators are presently undergoing a detailed scrutiny and review by various scientific and professional organizations as well as the Government. A number of new factors has complicated the supply/demand equation. These include considerations of cost versus needs, reliability factors, mission orientation, research and educational components, and commercial viability. This paper will focus on the present status and projected needs of radioisotope production with high-energy accelerators in the US, and will compare and examine the existing infrastructure in other countries for this purpose.

  4. Variations in Nutrient and Energy Supplies as Foundations for Hydrothermal Ecosystems

    NASA Astrophysics Data System (ADS)

    Shock, E. L.

    2008-12-01

    Our field work at Yellowstone National Park, and associated analytical and theoretical work, is guided by the hypothesis that the enormous phylogenetic diversity of hot spring microbial communities reflects the metabolic diversity that is allowed by the geochemical diversity of nutrient and energy supplies. Wide-ranging fluid compositions result from differences in fluid sources, host rock compositions, the extent of water-rock reaction progress, phase separation, subsurface mixing with groundwater or soil water, atmospheric exchange, aeolian deposition, and biological activity. In the systems we have studied pH varies from 0.8 to 9.3, and serves as a reference frame for other variations in composition. Major nutrients show several order of magnitude variations (phosphate from 0.0005 to 0.05 millimolal, nitrate from micro to millimolal, ammonia from micro to 0.1 molal). Micronutrients also have highly variable concentrations (Mo and V over 3; Zn, W and Mn over 5; and Fe over 6 orders of magnitude). As a consequence, the combined multi-component compositional diversity presents an enormous array of possible geochemical habitats. Likewise, the supply of chemical energy in hot spring ecosystems varies with composition, with some reactions universally providing similar amounts of energy (oxidation of CO, formate, hydrogen, ammonia, magnetite or methane), while others change dramatically depending on subtleties of fluid composition (ferrous ion oxidation coupled to reduction of oxygen, nitrate, or nitrite; sulfur disproportionation to pyrite and sulfate). Increasing pH amplifies the energy yield from reactions in which sulfur is reduced to pyrite, or in which ferrous ions are oxidized, while at strongly acidic pH, magnetite rivals oxygen in energy yield for oxidation reactions. Chemical affinities for many reactions change sign from one spring to the next, exemplified by the coupling of ferrous ion oxidation to magnetite, hematite or goethite with sulfur reduction to

  5. Policy implications of the GRI baseline projection of U. S. energy supply and demand to 2010, 1992

    SciTech Connect

    Not Available

    1992-01-01

    The 1992 Edition of the GRI Baseline Projection of U.S. Energy Supply and Demand is summarized. Three broad implications concerning the future of the natural gas industry are highlighted: the residual impact of the August 1990 Gulf War on crude oil prices and the factors influencing the long-term price path, the impact of the growing number of environmental constraints on future energy use, and the effect of recent developments in gas production on future gas supply and price.

  6. Weathering the cold of `94. A review of the January 1994 energy supply disruptions in the Eastern United States

    SciTech Connect

    1995-05-01

    This report examines the causes of and responses to the very low temperatures over a wide region of the Eastern US causing unprecedented sustained demand for energy during the week of January 16--22, 1994. The topics of the report include the vagaries of the weather, the North American power supply structure, a chronology of major events of January, natural gas industry operations during peak demand periods, and recommendations for fuel supply, load forecasting, and energy emergency response exercises.

  7. Lithuanian Energy Security: Lithuania’s Dependence on Energy Supply From Russia

    DTIC Science & Technology

    2011-03-16

    unsuccessful aspirations to purchase the oil refinery Mazeikiu nafta , which provides vitally needed tax revenue for Lithuania (accounting for 10 percent...and oil is used as a means of bribing and blackmail against Eastern European countries. This monopoly assists Moscow in creating alternative transit...great energy resources – its territory contains 1/3 of the world natural gas reserves, 1/10 of oil reserves, 1/5 of coal reserves and 14 % of uranium

  8. Meeting today's challenges to supply tomorrow's energy. Clean fossil energy technical and policy seminar

    SciTech Connect

    2005-07-01

    Papers discussed the coal policy of China, Russia, Indonesia and Vietnam; clean coal technology (small-scale coal power plants, carbon capture and sequestration, new coking process SCOPE21, coal gasification (HyPr-RING), CO{sub 2} reduction technology, Supercritical coal-fired units and CFB boilers, EAGLE project, coal liquefaction), the coal consumer's view of clean fossil energy policy, and natural gas policy and technology. Some of the papers only consist of the presentation overheads/viewgraphs.

  9. Supply and demand for alcohol in Australia: relationships between industry structures, regulation and the marketplace.

    PubMed

    Stockwell, T; Crosbie, D

    2001-07-01

    Aspects of alcohol supply and demand relationships are examined in relation to the two main beverage varieties in Australia, wine and beer. It is argued that this case study illustrates how the 'supply side' is able to create and protect demand for alcohol through both taking advantage of and influencing government regulation of the market for alcohol. In relation to low alcohol beer the impact on public health and safety has been extremely positive. In relation to the creation of cask wine in the late 1960s there have been demonstrably deleterious effects. Preferential taxation arrangements for the Australian wine industry have dramatically increased both exports and home consumption. One unintended consequence has been the creation of a major new market for cheap bulk wines that have had a devastating public health impact, particularly on Aboriginal communities, and also the invention of 'alco-pops'. Two-thirds of all table wine consumed in Australia now comes in a cask and 90% of this product is manufactured by three multi-national companies that wield enormous power and political influence to maintain the status quo. The Australian beer industry is well known internationally for its export of 'full strength' (around 5% by volume) beers. What is less well known is its commercial success in the development of low and mid-strength varieties for home consumption. In some States these now comprise 40% by volume of the beer market. This development can largely be attributed to State taxation arrangements, to drink-driving law enforcement, marketing strategies and to a decade of intense competition between several major brewers. This case study indicates how alcohol taxation policy can have major impacts on public health (both positive and negative) but that in a modern market economy it is difficult for governments to act in the public interest due to pressures from vested interest groups.

  10. Hypothalamic proopiomelanocortin processing and the regulation of energy balance

    PubMed Central

    Wardlaw, Sharon L.

    2011-01-01

    Hypothalamic proopiomelanocortin (POMC) neurons play a key role in regulating energy balance and neuroendocrine function. Much attention has been focused on regulation of POMC gene expression with less emphasis on regulated peptide processing. This is particularly important given the complexity of posttranslational POMC processing which is essential for the generation of biologically active MSH peptides. Mutations that impair POMC sorting and processing are associated with obesity in humans and in animals. Specifically, mutations in the POMC processing enzymes prohormone convertase 1/3 (PCI/3) and in carboxypeptidase E (CPE) and in the α-MSH degrading enzyme, PRCP, are associated with changes in energy balance. There is increasing evidence that POMC processing is regulated with respect to energy balance. Studies have implicated both the leptin and insulin signaling pathways in the regulation of POMC at various steps in the processing pathway. This article will review the role of hypothalamic POMC in regulating energy balance with a focus on POMC processing. PMID:21208604

  11. Emergency and backup power supplies at Department of Energy facilities: Augmented Evaluation Team -- Final report

    SciTech Connect

    Not Available

    1993-11-01

    This report documents the results of the Defense Programs (DP) Augmented Evaluation Team (AET) review of emergency and backup power supplies (i.e., generator, uninterruptible power supply, and battery systems) at DP facilities. The review was conducted in response to concerns expressed by former Secretary of Energy James D. Watkins over the number of incidents where backup power sources failed to provide electrical power during tests or actual demands. The AET conducted a series of on-site reviews for the purpose of understanding the design, operation, maintenance, and safety significance of emergency and backup power (E&BP) supplies. The AET found that the quality of programs related to maintenance of backup power systems varies greatly among the sites visited, and often among facilities at the same site. No major safety issues were identified. However, there are areas where the AET believes the reliability of emergency and backup power systems can and should be improved. Recommendations for improving the performance of E&BP systems are provided in this report. The report also discusses progress made by Management and Operating (M&O) contractors to improve the reliability of backup sources used in safety significant applications. One area that requires further attention is the analysis and understanding of the safety implications of backup power equipment. This understanding is needed for proper graded-approach implementation of Department of Energy (DOE) Orders, and to help ensure that equipment important to the safety of DOE workers, the public, and the environment is identified, classified, recognized, and treated as such by designers, users, and maintainers. Another area considered important for improving E&BP system performance is the assignment of overall ownership responsibility and authority for ensuring that E&BP equipment performs adequately and that reliability and availability are maintained at acceptable levels.

  12. Methods of reducing energy consumption of the oxidant supply system for MHD/steam power plants

    NASA Technical Reports Server (NTRS)

    Juhasz, A. J.

    1983-01-01

    An in-depth study was conducted to identify possible improvements to the oxidant supply system for combined cycle MHD power plants which would lead to higher thermal efficiency and reduction in the cost of electricity, COE. Results showed that the oxidant system energy consumption could be minimized when the process was designed to deliver a product O2 concentration of 70 mole percent. The study also led to the development of a new air separation process, referred to as 'liquid pumping and internal compression'. MHD system performance calculations show that the new process would permit an increase in plant thermal efficiency of 0.6 percent while allowing more favorable tradeoffs between magnetic energy and oxidant system capacity requirements.

  13. Methods of reducing energy consumption of the oxidant supply system for MHD/steam power plants

    NASA Technical Reports Server (NTRS)

    Juhasz, A. J.

    1983-01-01

    An in-depth study was conducted to identify possible improvements to the oxidant supply system for combined cycle MHD power plants which would lead to higher thermal efficiency and reduction in the cost of electricity, COE. Results showed that the oxidant system energy consumption could be minimized when the process was designed to deliver a product O2 concentration of 70 mole percent. The study also led to the development of a new air separation process, referred to as liquid pumping and internal compression. MHD system performance calculations show that the new process would permit an increase in plant thermal efficiency of 0.6 percent while allowing more favorable tradeoffs between magnetic energy and oxidant system capacity requirements.

  14. Methods of reducing energy consumption of the oxidant supply system for MHD/steam power plants

    NASA Technical Reports Server (NTRS)

    Juhasz, A. J.

    1983-01-01

    An in-depth study was conducted to identify possible improvements to the oxidant supply system for combined cycle MHD power plants which would lead to higher thermal efficiency and reduction in the cost of electricity, COE. Results showed that the oxidant system energy consumption could be minimized when the process was designed to deliver a product O2 concentration of 70 mole percent. The study also led to the development of a new air separation process, referred to as 'liquid pumping and internal compression'. MHD system performance calculations show that the new process would permit an increase in plant thermal efficiency of 0.6 percent while allowing more favorable tradeoffs between magnetic energy and oxidant system capacity requirements.

  15. Energy supply processes for magnetospheric substorms and solar flares - Tippy bucket model or pitcher model?

    NASA Technical Reports Server (NTRS)

    Akasofu, S.-I.

    1985-01-01

    In the past, both magnetospheric substorms and solar flares have almost exclusively been discussed in terms of explosive magnetic reconnection. Such a model may conceptually be illustrated by the so-called 'tippy-bucket model', which causes sudden unloading processes, namely a sudden (catastrophic, stochastic, and unpredictable) conversion of stored magnetic energy. However, recent observations indicate that magnetospheric substorms can be understood as a result of a directly driven process which can conceptually be illustrated by the 'pitcher model' in which the output rate varies in harmony with the input rate. It is also possible that solar flare phenomena are directly driven by a photospheric dynamo. Thus, explosive magnetic reconnection may simply be an unworkable hypothesis and may not be a puzzle to be solved as the primary energy supply process for magnetospheric substorms and solar flares.

  16. Underground coal gasification with integrated carbon dioxide mitigation supports Bulgaria's low carbon energy supply

    NASA Astrophysics Data System (ADS)

    Nakaten, Natalie; Kempka, Thomas; Azzam, Rafig

    2013-04-01

    plants can be economically substituted by low carbon based technologies. Furthermore, the integrated annual load management notably contributes to innovative process integration becoming economic in an energy system affected by low efficiency and flexibility. Further limiting flexibility, the geographic location of this innovative low carbon energy production technology strictly depends on geological boundary conditions, namely the presence of exploitable coal resources, and availability of energy transport networks to supply potential end users with the product. Hereby, feeding upgraded synthesis gas directly into the Bulgarian gas pipeline network avoiding its conversion into electricity is an alternative approach with relevant economic potentials. For that purpose, the proximity and availability of these transport networks as well as the demand of end users are validated by the integrated energy system model. Coupling our techno-economic process model to an energy system-modelling framework allows the determination of the future economical potentials and the limitations for the implementation of a low carbon energy production technology into the Bulgarian energy system. The obtained results show that the Bulgarian energy system can significantly benefit from the integration of underground coal gasification considering carbon dioxide mitigation technologies potentially initiating a continuous substitution of imported fuels by domestic coal resources.

  17. Serotonin and the regulation of mammalian energy balance

    PubMed Central

    Donovan, Michael H.; Tecott, Laurence H.

    2013-01-01

    Maintenance of energy balance requires regulation of the amount and timing of food intake. Decades of experiments utilizing pharmacological and later genetic manipulations have demonstrated the importance of serotonin signaling in this regulation. Much progress has been made in recent years in understanding how central nervous system (CNS) serotonin systems acting through a diverse array of serotonin receptors impact feeding behavior and metabolism. Particular attention has been paid to mechanisms through which serotonin impacts energy balance pathways within the hypothalamus. How upstream factors relevant to energy balance regulate the release of hypothalamic serotonin is less clear, but work addressing this issue is underway. Generally, investigation into the central serotonergic regulation of energy balance has had a predominantly “hypothalamocentric” focus, yet non-hypothalamic structures that have been implicated in energy balance regulation also receive serotonergic innervation and express multiple subtypes of serotonin receptors. Moreover, there is a growing appreciation of the diverse mechanisms through which peripheral serotonin impacts energy balance regulation. Clearly, the serotonergic regulation of energy balance is a field characterized by both rapid advances and by an extensive and diverse set of central and peripheral mechanisms yet to be delineated. PMID:23543912

  18. Electric vehicle (EV) storage supply chain risk and the energy market: A micro and macroeconomic risk management approach

    NASA Astrophysics Data System (ADS)

    Aguilar, Susanna D.

    As a cost effective storage technology for renewable energy sources, Electric Vehicles can be integrated into energy grids. Integration must be optimized to ascertain that renewable energy is available through storage when demand exists so that cost of electricity is minimized. Optimization models can address economic risks associated with the EV supply chain- particularly the volatility in availability and cost of critical materials used in the manufacturing of EV motors and batteries. Supply chain risk can reflect itself in a shortage of storage, which can increase the price of electricity. We propose a micro-and macroeconomic framework for managing supply chain risk through utilization of a cost optimization model in combination with risk management strategies at the microeconomic and macroeconomic level. The study demonstrates how risk from the EVs vehicle critical material supply chain affects manufacturers, smart grid performance, and energy markets qualitatively and quantitatively. Our results illustrate how risk in the EV supply chain affects EV availability and the cost of ancillary services, and how EV critical material supply chain risk can be mitigated through managerial strategies and policy.

  19. Energy metabolism, fuel selection and body weight regulation.

    PubMed

    Galgani, J; Ravussin, E

    2008-12-01

    Energy homeostasis is critical for the survival of species. Therefore, multiple and complex mechanisms have evolved to regulate energy intake and expenditure to maintain body weight. For weight maintenance, not only does energy intake have to match energy expenditure, but also macronutrient intake must balance macronutrient oxidation. However, this equilibrium seems to be particularly difficult to achieve in individuals with low fat oxidation, low energy expenditure, low sympathetic activity or low levels of spontaneous physical activity, as in addition to excess energy intake, all of these factors explain the tendency of some people to gain weight. Additionally, large variability in weight change is observed when energy surplus is imposed experimentally or spontaneously. Clearly, the data suggest a strong genetic influence on body weight regulation implying a normal physiology in an 'obesogenic' environment. In this study, we also review evidence that carbohydrate balance may represent the potential signal that regulates energy homeostasis by impacting energy intake and body weight. Because of the small storage capacity for carbohydrate and its importance for metabolism in many tissues and organs, carbohydrate balance must be maintained at a given level. This drive for balance may in turn cause increased energy intake when consuming a diet high in fat and low in carbohydrate. If sustained over time, such an increase in energy intake cannot be detected by available methods, but may cause meaningful increases in body weight. The concept of metabolic flexibility and its impact on body weight regulation is also presented.

  20. Energy metabolism, fuel selection and body weight regulation

    PubMed Central

    Galgani, J; Ravussin, E

    2010-01-01

    Energy homeostasis is critical for the survival of species. Therefore, multiple and complex mechanisms have evolved to regulate energy intake and expenditure to maintain body weight. For weight maintenance, not only does energy intake have to match energy expenditure, but also macronutrient intake must balance macronutrient oxidation. However, this equilibrium seems to be particularly difficult to achieve in individuals with low fat oxidation, low energy expenditure, low sympathetic activity or low levels of spontaneous physical activity, as in addition to excess energy intake, all of these factors explain the tendency of some people to gain weight. Additionally, large variability in weight change is observed when energy surplus is imposed experimentally or spontaneously. Clearly, the data suggest a strong genetic influence on body weight regulation implying a normal physiology in an ‘obesogenic’ environment. In this study, we also review evidence that carbohydrate balance may represent the potential signal that regulates energy homeostasis by impacting energy intake and body weight. Because of the small storage capacity for carbohydrate and its importance for metabolism in many tissues and organs, carbohydrate balance must be maintained at a given level. This drive for balance may in turn cause increased energy intake when consuming a diet high in fat and low in carbohydrate. If sustained over time, such an increase in energy intake cannot be detected by available methods, but may cause meaningful increases in body weight. The concept of metabolic flexibility and its impact on body weight regulation is also presented. PMID:19136979

  1. 76 FR 34634 - Federal Acquisition Regulation; Prioritizing Sources of Supplies and Services for Use by the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    ... Strategic Sourcing Initiative (FSSI) agreements). The existing contracts and instruments are not listed in...) under Federal Supply Schedule contracts (e.g., Federal Strategic Sourcing Initiative (FSSI) agreements...

  2. Supply evaluation of a herbaceous and woody energy crop at three midwest regions

    SciTech Connect

    English, B.C.; Dillivan, K.D.; Ojo, M.A.

    1994-12-31

    While substantial research has been conducted on the argronomic issues of biomass production and on the processes of converting biofuel crops into energy, little work has been completed analyzing the economic and physical impacts of biofuel production on an agriculturally based region. Acres currently devoted to traditional crops will be replaced by biomass crops if such a conversion proves to be economically attractive. These shifts could have impacts on local and regional levels of farm income, current farmland market values, commodity prices received, and the demand for and prices of farm level inputs. This paper examines the economic and physical ramifications of introducing biomass production to three Midwest regions centered in the following counties; Cass County, North Dakota, Olmsted County, Minnesota, and Orange County, Indiana. Using a regional linear programming model that maximizes net returns to producers subject to several constraints, a supply curve for biomass is developed for each of the three regions. The model predicts that at a plant gate price of $26, $40, and $52 per dry ton, biomass begins to enter into production in the Cass, Olmsted, and Orange Regions respectively. Prices of $28, $44, and $54 per dry ton of biomass are sufficient to supply a quantity necessary to operate a power plant requiring 5,000 dry tons per day in Cass, Olmsted, and Orange regions respectively. In the Olmsted and Orange regions, biomass production results in fertilizer being applied, however, in the Cass Region a slight increase in fertilizer use corresponds to biomass production.

  3. State of and prospects for automation of energy-supply sources of iron and steel industry enterprises

    NASA Astrophysics Data System (ADS)

    Kryukov, G. Y.; Lyambakh, R. V.; Lyashenko, L. E.; Sergeev, A. D.

    1982-07-01

    Automation at various levels of items of the energy management of enterprises belonging to the iron and steel industry is considered in the light of recent developments and the energy-supply situation as a whole. Examples of benefits obtained through automation are given.

  4. What is the Efficiency of ATP Signaling from Erythrocytes to Regulate Distribution of O2 Supply within the Microvasculature?

    PubMed Central

    C.G., Ellis; S., Milkovich; D., Goldman

    2012-01-01

    Erythrocytes appear to be ideal sensors for regulating microvascular O2 supply since they release the potent vasodilator adenosine 5′-triphosphate (ATP) in an O2 saturation dependent manner. Whether erythrocytes play a significant role in regulating O2 supply in the complex environment of diffusional O2 exchange among capillaries, arterioles and venules, depends on the efficiency with which erythrocytes signal the vascular endothelium. If one assumes that the distribution of purinergic receptors is uniform throughout the microvasculature, then the most efficient site for signaling should occur in capillaries, where the erythrocyte membrane is in close proximity to the endothelium. ATP released from erythrocytes would diffuse a short distance to P2y receptors inducing an increase in blood flow possibly the result of endothelial hyperpolarization. We hypothesize that this hyperpolarization varies across the capillary bed dependent upon erythrocyte supply rate and the flux of O2 from these erythrocytes to support O2 metabolism. This would suggest that the capillary bed would be the most effective site for erythrocytes to communicate tissue oxygen needs. Electrically coupled endothelial cells conduct the integrated signal upstream where arterioles adjust vascular resistance, thus enabling ATP released from erythrocytes to regulate the magnitude and distribution of O2 supply to individual capillary networks. PMID:22587367

  5. What is the efficiency of ATP signaling from erythrocytes to regulate distribution of O(2) supply within the microvasculature?

    PubMed

    Ellis, Christopher G; Milkovich, Stephanie; Goldman, Daniel

    2012-07-01

    Erythrocytes appear to be ideal sensors for regulating microvascular O(2) supply as they release the potent vasodilator ATP in an O(2) saturation-dependent manner. Whether erythrocytes play a significant role in regulating O(2) supply in the complex environment of diffusional O(2) exchange among capillaries, arterioles, and venules, depends on the efficiency with which erythrocytes signal the vascular endothelium. If one assumes that the distribution of purinergic receptors is uniform throughout the microvasculature, then the most efficient site for signaling should occur in capillaries, where the erythrocyte membrane is in close proximity to the endothelium. ATP released from erythrocytes would diffuse a short distance to P(2y) receptors inducing an increase in blood flow, possibly the result of endothelial hyperpolarization. We hypothesize that this hyperpolarization varies across the capillary bed depending upon erythrocyte supply rate and the flux of O(2) from these erythrocytes to support O(2) metabolism. This would suggest that the capillary bed would be the most effective site for erythrocytes to communicate tissue oxygen needs. Electrically coupled endothelial cells conduct the integrated signal upstream where arterioles adjust vascular resistance, thus enabling ATP released from erythrocytes to regulate the magnitude and distribution of O(2) supply to individual capillary networks. © 2012 John Wiley & Sons Ltd.

  6. Appetite Regulation In Relation To Energy Provision.

    PubMed

    Fatima, Sadia; Ahmed, Nasir; Fatima, Fozia; Wazir, Salim

    2016-01-01

    Appetite control is a very complex process which influences the short term feeding behaviour and a long term adaptive process that responds to the energy input. Appetite control and food intake is influenced by a combination of behavioural, psychological and neuro-endocrine influences. For identification of articles search engines of the databases EMBASE, OVID, Pub med and MEDLINE were used for papers published from 2002 to 2015 in English language. The higher endogenous peptide YY (PYY) and cholecystokinin (CCK) and lower ghrelin levels are not always associated with subjective feelings of fullness or hunger and a decreased energy intake which highlights the fact that appetite control and food intake is a very intricate process. When food is ingested, numerous physiological, hormonal, social and psychological processes are triggered in an intricate manner. Therefore, it can be said that ghrelin, PYY and CCK are just few pieces, which contributes to the process of appetite control and energy intake.

  7. Marihuana Medical Access Regulations unconstitutional because they do not provide for legal source or supply of marijuana.

    PubMed

    Betteridge, Glenn

    2003-04-01

    In a 9 January 2003 ruling in Hitzig, the Ontario Superior Court of Justice determined that the Marihuana Medical Access Regulations (MMAR) fail to provide for a legal source and safe supply of marijuana. This failure infringed the applicants' section 7 Charter rights to liberty and security of the person in a manner inconsistent with the principles of fundamental justice. The MMAR could not be saved under section I of the Charter. The Court declared the MMAR invalid, but suspended that order for six months to allow the government to decide how to create a legal source and supply of marijuana.

  8. The brain endocannabinoid system in the regulation of energy balance.

    PubMed

    Richard, Denis; Guesdon, Benjamin; Timofeeva, Elena

    2009-02-01

    The role played by the endocannabinoid system in the regulation of energy balance is currently generating a great amount of interest among several groups of investigators. This interest in large part comes from the urgent need to develop anti-obesity and anti-cachexia drugs around target systems (such as the endocannabinoid system), which appears to be genuinely involved in energy balance regulation. When activated, the endocannabinoid system favors energy deposition through increasing energy intake and reducing energy expenditure. This system is activated in obesity and following food deprivation, which further supports its authentic function in energy balance regulation. The cannabinoid receptor type 1 (CB1), one of the two identified cannabinoid receptors, is expressed in energy-balance brain structures that are also able to readily produce or inactivate N-arachidonoyl ethanolamine (anandamide) and 2-arachidonoylglycerol (2AG), the most abundantly formed and released endocannabinoids. The brain action of endocannabinoid system on energy balance seems crucial and needs to be delineated in the context of the homeostatic and hedonic controls of food intake and energy expenditure. These controls require the coordinated interaction of the hypothalamus, brainstem and limbic system and it appears imperative to unravel those interplays. It is also critical to investigate the metabolic endocannabinoid system while considering the panoply of functions that the endocannabinoid system fulfills in the brain and other tissues. This article aims at reviewing the potential mechanisms whereby the brain endocannabinoid system influences the regulation energy balance.

  9. Physiologic regulation of body energy storage

    NASA Technical Reports Server (NTRS)

    Pitts, G. C.

    1978-01-01

    Both new and published data (rats, mice, and human beings) on three parameters - fat mass, fat-free body mass (FFBM), and total body mass in some cases - are evaluated. Steady state values of the parameters are analyzed for changes in response to specific perturbing agents and for their frequency distributions. Temporal sequences of values on individuals are examined for evidence of regulatory responses. The results lead to the hypothesis that the FFBM is regulated, but probably not as a unit, and that mass of fat is regulated with a high priority near the range extremes but with a much lower priority in the mid-range. Properties and advantages of such a mechanism are discussed.

  10. Impact of innovations on future energy supply - chemical enhanced oil recovery (CEOR).

    PubMed

    Bittner, Christian

    2013-01-01

    The International Energy Agency (IEA) expects an increase of global energy demand by one-third during next 20 years together with a change in the global energy mix. A key-influencing factor is a strong expected increase in oil and gas production in the United States driven by 'new' technologies such as hydraulic fracturing. Chemical enhanced oil recovery (CEOR) is another strong growing technology with the potential of a step change innovation, which will help to secure future oil supply by turning resources into reserves. While conventional production methods give access to on average only one-third of original oil in place, the use of surfactants and polymers allows for recovery of up to another third of this oil. In the case of polymer flooding with poly acrylamide, the number of full field implementations has increased in recent years. In the meantime new polymers have been developed to cover previously unmet needs - such polymers can be applied in fields of high salinity and high temperature. Use of surfactants is in an earlier stage, but pilot tests show promising results.

  11. Supply and demand for wood as a source of energy in Zambia: An econometric analysis

    SciTech Connect

    Mupimpila, C.

    1993-01-01

    This study examines the status of biomass energy in Zambia. In its current usage, the concept of biomass energy often implies woodfuel because woodfuel is the main biomass energy. This study develops an econometric model of household woodfuel demand and also evaluates the supply of woodfuel in Zambia. The study finds that there are significant sectoral differences in woodfuel demand between the rural and urban sectors. In the rural sector, inflation is by far the most significant determinant of household woodfuel demand. The coefficients on inflation are statistically significant at better than the one percent level and also have expected positive signs. In the urban sector, inflation is again by far the most significant determinant of woodfuel demand. However, in the urban sector, household income and woodfuel price are also significant determinants of demand. The coefficients on inflation, household income, and woodfuel price are all significant at better than the one percent level and have expected signs. The income elasticity of woodfuel demand is positive, suggesting that in the short-run, woodfuel is a normal good. However, the elasticity of woodfuel demand with respect to growth in investment is negative, indicating that long-run structural change in the economy reduces woodfuel demand.

  12. Preparation and evaluation of easy energy supply property of medium-chain fatty acids liposomes.

    PubMed

    Liu, Weilin; Liu, Wei; Liu, Chengmei; Liu, Jianhua; Zheng, Huijuan; Yang, Shuibing; Su, Jiahong

    2011-01-01

    To develop an easy-energy-supply agent, medium-chain fatty acids (MCFAs) liposomes were prepared by thin-layer dispersion, freeze-thawing and dynamic high pressure microfluidization (DHPM)-freeze-thawing methods. Results showed that MCFAs nanoliposomes obtained by the novel method (DHPM-freeze-thawing) exhibited a smaller size (72.6 ± 4.9 nm), narrower size distribution (PDI = 0.175 ± 0.005), higher zeta potential (-41.27 ± 1.16 mV) and entrapment efficiency (45.9 ± 6.0%) compared to the other two methods. In the weight-loaded swimming test of the mice, the high-dose group of MCFAs nanoliposomes indicated a significantly longer swimming time (105 ± 31 min, p < 0.05), a lower serum urea nitrogen (839.5 ± 111.9 mg/L, p < 0.05) and blood lactic acid (5.7 ± 1.0 mmol/L, p ≤ 0.001), and a higher hepatic glycogen (15.0 ± 3.6 mg/g, p ≤ 0.001) than those of the control group (53 ± 13 min, 1153.6 ± 102.5 mg/L, 12.5 ± 1.9 mmol/L and 8.8 ± 3.3 mg/g, respectively). However, no significant difference was found between the high-dose group and MCFAs group. The results suggested that MCFAs nanoliposomes could be used as a potential easy-energy-supply agent.

  13. Energy utilization, nitrogen balance and microbial protein supply in cattle fed Pennisetum purpureum and condensed tannins.

    PubMed

    Piñeiro-Vázquez, A T; Canul-Solis, J R; Alayón-Gamboa, J A; Chay-Canul, A J; Ayala-Burgos, A J; Solorio-Sánchez, F J; Aguilar-Pérez, C F; Ku-Vera, J C

    2017-02-01

    The aim of the experiment was to assess the effect of condensed tannins (CT) on feed intake, dry matter digestibility, nitrogen balance, supply of microbial protein to the small intestine and energy utilization in cattle fed a basal ration of Pennisetum purpureum grass. Five heifers (Bos taurus × Bos indicus) with an average live weight of 295 ± 19 kg were allotted to five treatments consisting of increasing levels of CT (0, 1, 2, 3 and 4% CT/kg DM) in a 5 × 5 Latin square design. Dry matter intake (DMI) was similar (p > 0.05) between treatments containing 0, 1, 2 and 3% of CT/kg DM and it was reduced (p < 0.05) to 4% CT (5.71 kg DM/day) with respect to that observed with 0% CT (6.65 kg DM/day). Nitrogen balance, purine derivatives excretion in urine, microbial protein synthesis and efficiency of synthesis of microbial nitrogen in the rumen were not affected (p ≥ 0.05) by the increase in the levels of condensed tannins in the ration. Energy loss as CH4 was on average 2.7% of the gross energy consumed daily. Metabolizable energy intake was 49.06 MJ/day in cattle fed low-quality tropical grass with a DMI of 6.27 kg/day. It is concluded that concentrations of CT between 2 and 3% of DM of ration reduced energy loss as CH4 by 31.3% and 47.6%, respectively, without affecting intakes of dry and organic matter; however, digestibilities of dry and organic matter are negatively affected. Journal of Animal Physiology and Animal Nutrition © 2016 Blackwell Verlag GmbH.

  14. Analysis of Diurnal Variations in Energy Footprint and Its Associated Carbon Emission for Water Supply and Reuse in Arid and Semi-Arid Areas

    NASA Astrophysics Data System (ADS)

    Sobhani, Reza

    characterized by water scarcity, such as Southern California, groundwater containing chromophoric dissolved organic matter is a viable source of water supply. However, the seawater intrusion increased the concentration of bromide in extracted groundwater. Bromide, a precursor to bromate formation is regulated by USEPA as a potential carcinogen. This study compares the energy footprint among the two processes utilized for treatment of highly colored groundwater (i.e. nanofiltration and ozone injection coupled with biologically activated carbon) and discusses the impacts of bromate formation among these processes.

  15. Appraisal and regulation of the ship energy performance

    NASA Astrophysics Data System (ADS)

    Badea, N.; Epureanu, A.; Badea, G. V.; Frumuşanu, G.

    2015-11-01

    The ship may be viewed as a living environment associated with two industrial environments, one corresponding to the transport industry and other one to the processing, services, or other specific type of industry developed aboard. Each environment has its own energy system and changes energy with the other two. Nowadays, the appraisal and regulation of the ship energy performance is based on the Energy Efficiency Design Index (EEDI). Its definition covers the three mentioned systems, without distinction between them. This paper addresses the assessment and regulation of the ship energy performance, bearing in mind that, by far, the main purpose is to increase the level of performance by selecting, from the available measures of performance improvement, those that are the most effective. The paper highlights the EEDI shortcomings, explaining that they appear mainly due the fact that this index covers a couple of energy systems that are far too different (though these energy systems are intimately interpenetrated).

  16. Measuring the embodied energy in drinking water supply systems: a case study in the Great Lakes region.

    PubMed

    Mo, Weiwei; Nasiri, Fuzhan; Eckelman, Matthew J; Zhang, Qiong; Zimmerman, Julie B

    2010-12-15

    A sustainable supply of both energy and water is critical to long-term national security, effective climate policy, natural resource sustainability, and social wellbeing. These two critical resources are inextricably and reciprocally linked; the production of energy requires large volumes of water, while the treatment and distribution of water is also significantly dependent upon energy. In this paper, a hybrid analysis approach is proposed to estimate embodied energy and to perform a structural path analysis of drinking water supply systems. The applicability of this approach is then tested through a case study of a large municipal water utility (city of Kalamazoo) in the Great Lakes region to provide insights on the issues of water-energy pricing and carbon footprints. Kalamazoo drinking water requires approximately 9.2 MJ/m(3) of energy to produce, 30% of which is associated with indirect inputs such as system construction and treatment chemicals.

  17. The Physiological Regulation of Skeletal Muscle Fatty Acid Supply and Oxidation During Moderate-Intensity Exercise.

    PubMed

    van Hall, Gerrit

    2015-11-01

    Energy substrates that are important to the working muscle at moderate intensities are the non-esterified fatty acids (NEFAs) taken up from the circulation and NEFAs originating from lipolysis of the intramuscular triacylglycerol (IMTAG). Moreover, NEFA from lipolysis via lipoprotein lipase (LPL) in the muscle of the very-low-density lipoproteins and in the (semi) post-prandial state chylomicrons may also contribute. In this review, the NEFA fluxes and oxidation by skeletal muscle during prolonged moderate-intensity exercise are described in terms of the integration of physiological systems. Steps involved in the regulation of the active muscle NEFA uptake include (1) increased energy demand; (2) delivery of NEFA to the muscle; (3) transport of NEFA into the muscle by NEFA transporters; and (4) activation of the NEFAs and either oxidation or re-esterification into IMTAG. The increased metabolic demand of the exercising muscle is the main driving force for all physiological regulatory processes. It elicits functional hyperemia, increasing the recruitment of capillaries and muscle blood flow resulting in increased NEFA delivery and accessibility to NEFA transporters and LPL. It also releases epinephrine that augments adipose tissue NEFA release and thereby NEFA delivery to the active muscle. Moreover, NEFA transporters translocate to the plasma membrane, further increasing the NEFA uptake. The majority of the NEFAs taken up by the active muscle is oxidized and a minor portion is re-esterified to IMTAG. Net IMTAG lipolysis occurs; however, the IMTAG contribution to total fat oxidation is rather limited compared to plasma-derived NEFA oxidation, suggesting a complex role and regulation of IMTAG utilization.

  18. Beyond Renewable Portfolio Standards: An Assessment of Regional Supply and Demand Conditions Affecting the Future of Renewable Energy in the West; Report and Executive Summary

    SciTech Connect

    Hurlbut, D. J.; McLaren, J.; Gelman, R.

    2013-08-01

    This study assesses the outlook for utility-scale renewable energy development in the West once states have met their renewable portfolio standard (RPS) requirements. In the West, the last state RPS culminates in 2025, so the analysis uses 2025 as a transition point on the timeline of RE development. Most western states appear to be on track to meet their final requirements, relying primarily on renewable resources located relatively close to the customers being served. What happens next depends on several factors including trends in the supply and price of natural gas, greenhouse gas and other environmental regulations, consumer preferences, technological breakthroughs, and future public policies and regulations. Changes in any one of these factors could make future renewable energy options more or less attractive.

  19. Genetic regulation of feed intake and energy balance in poultry.

    PubMed

    Richards, M P

    2003-06-01

    Intensive selection by poultry breeders over many generations for economically important production traits such as growth rate and meat production has been accompanied by significant changes in feed intake and energy balance. For example, the modern commercial broiler, selected for rapid growth and enhanced muscle mass, does not adequately regulate voluntary feed intake to achieve energy balance. When given unrestricted access to feed, broilers exhibit hyperphagia leading to an excessive accumulation of energy (fat) stores, making these birds prone to obesity and other health-related problems. Humoral and neural pathways have been identified and studied in mammals that link appetite and energy balance. A series of highly integrated regulatory mechanisms exists for both of these processes involving complex interactions between peripheral tissues and the central nervous system. Within the central nervous system, the brainstem and the hypothalamus play critical roles in the regulation of feed intake and energy balance. Genes encoding key regulatory factors such as hormones, neuropeptides, receptors, enzymes, transcription factors, and binding/transport proteins constitute the molecular basis for regulatory systems that derive from integrated sensing, signaling, and metabolic pathways. However, we do not yet have a complete understanding of the genetic basis for this regulation in poultry. This review examines what is currently known about the regulation of feed intake and energy balance in poultry. A better understanding of the genes associated with controlling feed intake and energy balance and how their expression is regulated by nutritional and hormonal stimuli will offer new insights into current poultry breeding and management practices.

  20. Regulation of energy balance by inflammation: common theme in physiology and pathology.

    PubMed

    Wang, Hui; Ye, Jianping

    2015-03-01

    Inflammation regulates energy metabolism in both physiological and pathological conditions. Pro-inflammatory cytokines involves in energy regulation in several conditions, such as obesity, aging (calorie restriction), sports (exercise), and cancer (cachexia). Here, we introduce a view of integrative physiology to understand pro-inflammatory cytokines in the control of energy expenditure. In obesity, chronic inflammation is derived from energy surplus that induces adipose tissue expansion and adipose tissue hypoxia. In addition to the detrimental effect on insulin sensitivity, pro-inflammatory cytokines also stimulate energy expenditure and facilitate adipose tissue remodeling. In caloric restriction (CR), inflammatory status is decreased by low energy intake that results in less energy supply to immune cells to favor energy saving under caloric restriction. During physical exercise, inflammatory status is elevated due to muscle production of pro-inflammatory cytokines, which promote fatty acid mobilization from adipose tissue to meet the muscle energy demand. In cancer cachexia, chronic inflammation is elevated by the immune response in the fight against cancer. The energy expenditure from chronic inflammation contributes to weight loss. Immune tolerant cancer cells gains more nutrients during the inflammation. In these conditions, inflammation coordinates energy distribution and energy demand between tissues. If the body lacks response to the pro-inflammatory cytokines (Inflammation Resistance), the energy metabolism will be impaired leading to an increased risk for obesity. In contrast, super-induction of the inflammation activity leads to weight loss and malnutrition in cancer cachexia. In summary, inflammation is a critical component in the maintenance of energy balance in the body. Literature is reviewed in above fields to support this view.

  1. On the Integration of Wind and Solar Energy to Provide a Total Energy Supply in the U.S

    NASA Astrophysics Data System (ADS)

    Liebig, E. C.; Rhoades, A.; Sloggy, M.; Mills, D.; Archer, C. L.

    2009-12-01

    This study examines the feasibility of using renewable energy - mostly wind and solar radiation - as the primary sources of energy in the U.S., under the assumption that a nationwide electric transmission grid is in place. Previous studies have shown that solar output from California and Texas using energy storage is well correlated with the state energy load on an hour by hour basis throughout the year and with the US national load on a monthly basis. Other studies have shown that solar or wind alone can power the present US grid on average. This study explores scenarios for use of wind and solar energy together at the national scale on an hour by hour basis to determine if such a combination is a better match to national seasonal load scenarios than either of the two alone on an hour-by-hour basis. Actual hour by hour national load data from a particular year will be used as a basis, with some scenarios incorporating vehicle sector electrification and building heating and cooling using electric heat pumps. Hydro and geothermal generation can provide additional controllable output, when needed, to fulfill the hourly electricity and/or energy needs. Hourly wind speed data were calculated at the hub height of 80 m above the ground for the year 2006 at over 150 windy locations in the continental US using an extrapolation technique based on 10-m wind speed measurements and vertical sounding profiles. Using a 1.5 MW wind turbine as benchmark, the hourly wind power production nationwide was determined at all locations. Similarly, the hourly output from solar plants, with and without thermal storage, was calculated based on Ausra’s model assuming that the solar production would occur in the Southwest, the area with the greatest solar radiation density in the U.S. Hourly electricity demand for the year 2006 was obtained nationwide from a variety of sources, including the Federal Energy Regulation Commission. Hourly residential heating and cooking, industrial heat

  2. Evidence of Energy Supply by Active-Region Spicules to the Solar Atmosphere

    NASA Astrophysics Data System (ADS)

    Zeighami, S.; Ahangarzadeh Maralani, A. R.; Tavabi, E.; Ajabshirizadeh, A.

    2016-03-01

    We investigate the role of active-region spicules in the mass balance of the solar wind and energy supply in heating the solar atmosphere. We use high-cadence observations from the Solar Optical Telescope (SOT) onboard the Hinode satellite in the Ca ii H-line filter obtained on 26 January 2007. The observational technique provides the high spatio-temporal resolution required to detect fine structures such as spicules. We apply a Fourier power spectrum and wavelet analysis to Hinode/SOT time series of an active-region data set to explore the existence of coherent intensity oscillations. Coherent waves could be evidence of energy transport that serves to heat the solar atmosphere. Using time series, we measure the phase difference between two intensity profiles obtained at two different heights, which gives information about the phase difference between oscillations at those heights as a function of frequency. The results of a fast Fourier transform (FFT) show peaks in the power spectrum at frequencies in the range from 2 to 8 mHz at four different heights (above the limb), while the wavelet analysis indicates dominant frequencies similar to those of the Fourier power spectrum results. A coherency study indicates coherent oscillations at about 5.5 mHz (3 min). We measure mean phase speeds in the range 250-425 km s^{-1} increasing with height. The energy flux of these waves is estimated to be F = 1.8 × 106-11.2 × 106 erg cm^{-2} s^{-1} or 1.8-11.2 kW m^{-2}, which indicates that they are sufficiently energetic to accelerate the solar wind and heat the corona to temperatures of several million degrees. We compute the the mass flux carried by spicules of 3 × 10^{-10}-2 × 10^{-9} g cm^{-2} s^{-1}, which is 10-60 times higher than the mass that is carried away from the corona because of the solar wind (about 3 × 10^{-11} g cm^{-2} s^{-1}). Therefore, our results indicate that about 0.02-0.1 of the spicule mass is ejected from the corona, while the remainder reverts

  3. Decomposition and control of complex systems - Application to the analysis and control of industrial and economic systems /energy production/ with limited supplies

    NASA Astrophysics Data System (ADS)

    de Coligny, M.

    Optimized control strategies are developed for industrial installations where many variables of energy supply and storage are involved, with a particular focus on characteristics of a solar central tower power plant. It is shown that optimal regulation resides in controlling all disturbances which occur in a limited domain of the entire system, using robust control schemes. Choosing a command is then dependent on defining precise operational limits as constraints on the machines' performances. Attention is given to the development of variational principles used for the elements of the command logic. Particular consideration is given to a limited supply in storage in spatial and temporal terms. Commands for alterations in functions are then available on-line, and discontinuities are not a feature of the control system. The strategy is applied to the case of a field of heliostats and a central tower themal receiver showing that management is possible on the basis of a sliding horizon.

  4. PPARs: diverse regulators in energy metabolism and metabolic diseases.

    PubMed

    Wang, Yong-Xu

    2010-02-01

    The nuclear receptor PPARs are fundamentally important for energy homeostasis. Through their distinct yet overlapping functions and tissue distribution, the PPARs regulate many aspects of energy metabolism at the transcriptional level. Functional impairment or dysregulation of these receptors leads to a variety of metabolic diseases, while their ligands offer many metabolic benefits. Studies of these receptors have advanced our knowledge of the transcriptional basis of energy metabolism and helped us understand the pathogenic mechanisms of metabolic syndrome.

  5. Distribution System Voltage Regulation by Distributed Energy Resources

    SciTech Connect

    Ceylan, Oguzhan; Liu, Guodong; Xu, Yan; Tomsovic, Kevin

    2014-01-01

    This paper proposes a control method to regulate voltages in 3 phase unbalanced electrical distribution systems. A constrained optimization problem to minimize voltage deviations and maximize distributed energy resource (DER) active power output is solved by harmony search algorithm. IEEE 13 Bus Distribution Test System was modified to test three different cases: a) only voltage regulator controlled system b) only DER controlled system and c) both voltage regulator and DER controlled system. The simulation results show that systems with both voltage regulators and DER control provide better voltage profile.

  6. Amino acid and energy interrelationships in growing beef steers: II. Effects of energy intake and metabolizable lysine supply on growth.

    PubMed

    Ludden, P A; Kerley, M S

    1998-12-01

    We conducted three experiments to determine the optimal metabolizable Lys:net energy ratio for growth of beef calves. The single basal diet fed contained corn (56.1%), soybean hulls (18%), cottonseed hulls (15%), animal fat (4.25%), and corn gluten meal (5.6%). In Exp. 1, 54 steers were individually fed the basal diet at 1.5, 2.25, and 3.0 times NEm requirement; rations were top-dressed with 3.4 g of rumen-stable (RS) Met and either 0, 2, 4, 6, 8, or 12 g of RS-Lys daily. An additional 18 steers were fed the same three levels of energy and supplemented with 125 g of blood meal per steer. In Exp. 2, 68 crossbred steers were subjected to the same experimental protocol, with the exception that only the two highest levels of energy were used. Of these steers, 48 were fed individually and received the RS-Lys treatments; the remaining 20 steers received 125 g of blood meal per steer. No interaction (P > .10) was detected between level of supplemental Lys and energy intake in Exp. 1 or 2. Supplementation with RS-Lys improved (P < .01) ADG in Exp. 1, but it had no effect (P > .10) on growth in Exp. 2. The Lys requirement estimates were 44.3 and 51.3 g/d, corresponding to maximal growth rates of 1.21 and 1.64 kg/d for the 2.25 and 3.0 times maintenance treatments, respectively. Comparing the growth rates of steers fed supplemental Lys with those of steers fed blood meal in Exp. 1 and 2 revealed an ADG advantage (P < .03) with blood meal supplementation. To confirm the blood meal response, Exp. 3 used 75 crossbred steers fed the basal diet at 3.0 times NEm requirement plus either 3.4 g RS-Met, 3.4 g RS-Met and 12 g RS-Lys, or 125 g of blood meal per steer. Blood meal supplementation improved (P < .01) growth of steers over those fed supplemental Met or Met plus Lys. Although a distinct relationship between amino acid requirements and energy supply may exist, Lys and Met were not first-limiting in these experiments, or selective supplementation with undegradable protein may

  7. Energy metabolism regulated by HDAC inhibitor attenuates cardiac injury in hemorrhagic rat model

    PubMed Central

    Kuai, Qiyuan; Wang, Chunyan; Wang, Yanbing; Li, Weijing; Zhang, Gongqing; Qiao, Zhixin; He, Min; Wang, Xuanlin; Wang, Yu; Jiang, Xingwei; Su, Lihua; He, Yuezhong; Ren, Suping; Yu, Qun

    2016-01-01

    A disturbance of energy metabolism reduces cardiac function in acute severe hemorrhagic patients. Alternatively, adequate energy supply reduces heart failure and increases survival. However, the approach to regulating energy metabolism conductive to vital organs is limited, and the underlying molecular mechanism remains unknown. This study assesses the ability of histone deacetylase inhibitors (HDACIs) to preserve cardiac energy metabolism during lethal hemorrhagic injury. In the lethally hemorrhagic rat and hypoxic myocardial cells, energy metabolism and heart function were well maintained following HDACI treatment, as evident by continuous ATP production with normal cardiac contraction. Valproic acid (VPA) regulated the energy metabolism of hemorrhagic heart by reducing lactate synthesis and protecting the mitochondrial ultrastructure and respiration, which were attributable to the inhibition of lactate dehydrogenase A activity and the increased myeloid cell leukemia-1 (mcl-1) gene expression, ultimately facilitating ATP production and consumption. MCL-1, the key target of VPA, mediated this cardioprotective effect under acute severe hemorrhage conditions. Our results suggest that HDACIs promote cardioprotection by improving energy metabolism during hemorrhagic injury and could therefore be an effective strategy to counteract this process in the clinical setting. PMID:27910887

  8. Energy metabolism regulated by HDAC inhibitor attenuates cardiac injury in hemorrhagic rat model.

    PubMed

    Kuai, Qiyuan; Wang, Chunyan; Wang, Yanbing; Li, Weijing; Zhang, Gongqing; Qiao, Zhixin; He, Min; Wang, Xuanlin; Wang, Yu; Jiang, Xingwei; Su, Lihua; He, Yuezhong; Ren, Suping; Yu, Qun

    2016-12-02

    A disturbance of energy metabolism reduces cardiac function in acute severe hemorrhagic patients. Alternatively, adequate energy supply reduces heart failure and increases survival. However, the approach to regulating energy metabolism conductive to vital organs is limited, and the underlying molecular mechanism remains unknown. This study assesses the ability of histone deacetylase inhibitors (HDACIs) to preserve cardiac energy metabolism during lethal hemorrhagic injury. In the lethally hemorrhagic rat and hypoxic myocardial cells, energy metabolism and heart function were well maintained following HDACI treatment, as evident by continuous ATP production with normal cardiac contraction. Valproic acid (VPA) regulated the energy metabolism of hemorrhagic heart by reducing lactate synthesis and protecting the mitochondrial ultrastructure and respiration, which were attributable to the inhibition of lactate dehydrogenase A activity and the increased myeloid cell leukemia-1 (mcl-1) gene expression, ultimately facilitating ATP production and consumption. MCL-1, the key target of VPA, mediated this cardioprotective effect under acute severe hemorrhage conditions. Our results suggest that HDACIs promote cardioprotection by improving energy metabolism during hemorrhagic injury and could therefore be an effective strategy to counteract this process in the clinical setting.

  9. The Energy, Greenhouse Gas Emissions, and Cost Implications of Municipal Water Supply & Wastewater Treatment

    NASA Astrophysics Data System (ADS)

    Rodriguez-Winter, Thelma

    All man-made structures and materials have a design life. Across the United States there is a common theme for our water and wastewater treatment facilities and infrastructure. The design life of many of our mid 20 th century water and wastewater infrastructures in the United States have reached or are reaching life expectancy limits (ASCE, 2010). To compound the financial crisis of keeping up with the degradation, meeting and exceeding quality standards has never been more important in order to protect local fresh water supplies. This thesis analyzes the energy consumption of a municipal water and wastewater treatment system from a Lake Erie intake through potable treatment and back through wastewater treatment then discharge. The system boundary for this thesis includes onsite energy consumed by the treatment system and distribution/reclamation system as well as the energy consumed by the manufacturing of treatment chemicals applied during the study periods. By analyzing energy consumption, subsequent implications from greenhouse gas emissions and financial expenditures were quantified. Through the segregation of treatment and distribution processes from non-process energy consumption, such as heating, lighting, and air handling, this study identified that the potable water treatment system consumed an annual average of 2.42E+08 kBtu, spent 5,812,144 for treatment and distribution, and emitted 28,793 metric tons of CO2 equivalent emissions. Likewise, the wastewater treatment system consumed an annual average of 2.45E+08 kBtu, spent 3,331,961 for reclamation and treatment, and emitted 43,780 metric tons of CO2 equivalent emissions. The area with the highest energy usage, financial expenditure, and greenhouse gas emissions for the potable treatment facility and distribution system was from the manufacturing of the treatment chemicals, 1.10E+08 kBtu, 3.7 million, and 17,844 metric tons of CO2 equivalent, respectively. Of the onsite energy (1.4E-03 kWh per gallon

  10. Hypothalamic AMPK as a Regulator of Energy Homeostasis

    PubMed Central

    Huynh, My Khanh Q.; Kinyua, Ann W.; Yang, Dong Joo

    2016-01-01

    Activated in energy depletion conditions, AMP-activated protein kinase (AMPK) acts as a cellular energy sensor and regulator in both central nervous system and peripheral organs. Hypothalamic AMPK restores energy balance by promoting feeding behavior to increase energy intake, increasing glucose production, and reducing thermogenesis to decrease energy output. Besides energy state, many hormones have been shown to act in concert with AMPK to mediate their anorexigenic and orexigenic central effects as well as thermogenic influences. Here we explore the factors that affect hypothalamic AMPK activity and give the underlying mechanisms for the role of central AMPK in energy homeostasis together with the physiological effects of hypothalamic AMPK on energy balance restoration. PMID:27547453

  11. A bottom-up assessment method of limitations to and vulnerability of energy supply in developing countries

    NASA Astrophysics Data System (ADS)

    Lissner, Tabea; Olonscheck, Mady; Walther, Carsten; Kropp, Jürgen P.; Reusser, Dominik

    2015-04-01

    Sufficient energy access is essential for development and adequate livelihood conditions, as the majority of societal activities depend on reliable and sufficient energy. Especially in developing and threshold countries, energy access remains limited and intermittent. Moreover, compared to developed countries, often the expenditures for energy constitute a huge part of the available money. The vulnerability of energy systems to the impacts of climate change differs depending on the utilized source of energy. A special characteristic of developing and threshold countries is the fact that the spatial heterogeneity of the energy supply structure, especially between urban and rural regions, is generally larger than in developed countries, while the adaptive capacity of people is often much lower. A sound consideration of these complex conditions is a necessary basis for determining in how far climate change impacts can further diminish energy access in regions, where energy access is already limited. The topic of energy vulnerability has often been addressed for developed countries, but assessments for less developed countries remain scarce. On the one hand, data needed for energy vulnerability assessments, as they exist for the developed world, is usually not available. On the other hand, existing assessment methods for the developed world are often not transferable because they focus on specific supply infrastructure or energy carriers. Transferability is also hindered by the large differences in energy access and energy use patterns. We propose a novel approach to assess domestic energy supply vulnerability, by reversing the usual chain of assessment. On the basis of a basket of household energy needs for different purposes, we first assess which sources are used in order to fulfil specific energy needs. By focussing on the regionally specific energy carriers, we are able to significantly reduce data needs and assess directly, how energy vulnerability may play out

  12. [General profile of the nutrition surplus in Mexico from 1990-2013: An approach using the energy supplied by macronutrients and food groups].

    PubMed

    Hernández Ramírez, José Cutberto; Ortega Canto, Judith Elena

    2016-01-01

    This text analyzes the evolution of the excessive food energy supply in Mexico from 1990 to 2013. For each year, the energy and macronutrient requirements of the Mexican population were estimated and contrasted with the per capita energy supply. Discrepancies between requirement and supply were analyzed as a time series. The energy surplus ranged from 700 to 800 kcal per capita per day throughout the studied period and sugar/sweeteners contributed the highest above-requirement energy supply. Lipids excess increased steadily and intensely, mainly due to lipid increases from poultry and pork. Excess energy from alcoholic beverages tended to be concentrated into growing beer consumption. In summary, the energy supply and the corresponding surplus tended to be made up mainly of sugar/sweeteners and meat. This has direct implications for the prevalence of chronic non-communicable diseases as well as unsustainable use of land, water and energy.

  13. Hypothalamic proopiomelanocortin processing and the regulation of energy balance.

    PubMed

    Wardlaw, Sharon L

    2011-06-11

    Hypothalamic proopiomelanocortin (POMC) neurons play a key role in regulating energy balance and neuroendocrine function. Much attention has been focused on the regulation of POMC gene expression with less emphasis on regulated peptide processing. This is particularly important given the complexity of posttranslational POMC processing which is essential for the generation of biologically active MSH peptides. Mutations that impair POMC sorting and processing are associated with obesity in humans and in animals. Specifically, mutations in the POMC processing enzymes prohormone convertase 1/3 (PC1/3) and in carboxypeptidase E (CPE) and in the α-MSH degrading enzyme, PRCP, are associated with changes in energy balance. There is increasing evidence that POMC processing is regulated with respect to energy balance. Studies have implicated both the leptin and insulin signaling pathways in the regulation of POMC at various steps in the processing pathway. This article will review the role of hypothalamic POMC in regulating energy balance with a focus on POMC processing. Copyright © 2010 Elsevier B.V. All rights reserved.

  14. Natural Regulation of Energy Flow in a Green Quantum Photocell.

    PubMed

    Arp, Trevor B; Barlas, Yafis; Aji, Vivek; Gabor, Nathaniel M

    2016-12-14

    Manipulating the flow of energy in nanoscale and molecular photonic devices is of both fundamental interest and central importance for applications in light energy harvesting optoelectronics. Under erratic solar irradiance conditions, unregulated power fluctuations in a light-harvesting photocell lead to inefficient energy storage in conventional solar cells and potentially fatal oxidative damage in photosynthesis. Here, we compare the theoretical minimum energy fluctuations in nanoscale quantum heat engine photocells that incorporate one or two photon-absorbing channels and show that fluctuations are naturally suppressed in the two-channel photocell. This intrinsic suppression acts as a passive regulation mechanism that enables the efficient conversion of varying incident solar power into a steady output for absorption over a broad range of the solar spectrum on Earth. Remarkably, absorption in the green portion of the spectrum provides no inherent regulatory benefit, indicating that green light should be rejected in a photocell whose primary role is the regulation of energy flow.

  15. The Influence on Population Weight Gain and Obesity of the Macronutrient Composition and Energy Density of the Food Supply.

    PubMed

    Crino, Michelle; Sacks, Gary; Vandevijvere, Stefanie; Swinburn, Boyd; Neal, Bruce

    2015-03-01

    Rates of overweight and obesity have increased dramatically in all regions of the world over the last few decades. Almost all of the world's population now has ubiquitous access to low-cost, but highly-processed, energy-dense, nutrient-poor food products. These changes in the food supply, rather than decreases in physical activity, are most likely the primary driver of population weight gain and obesity. To-date, the majority of prevention efforts focus on personalised approaches targeting individuals. Population-wide food supply interventions addressing sodium and trans fat reduction have proven highly effective and comparable efforts are now required to target obesity. The evidence suggests that strategies focusing upon reducing the energy density and portion size of foods will be more effective than those targeting specific macronutrients. Government leadership, clearly specified targets, accountability and transparency will be the key to achieving the food supply changes required to address the global obesity epidemic.

  16. Novel Molecules Regulating Energy Homeostasis: Physiology and Regulation by Macronutrient Intake and Weight Loss

    PubMed Central

    Gavrieli, Anna

    2016-01-01

    Excess energy intake, without a compensatory increase of energy expenditure, leads to obesity. Several molecules are involved in energy homeostasis regulation and new ones are being discovered constantly. Appetite regulating hormones such as ghrelin, peptide tyrosine-tyrosine and amylin or incretins such as the gastric inhibitory polypeptide have been studied extensively while other molecules such as fibroblast growth factor 21, chemerin, irisin, secreted frizzle-related protein-4, total bile acids, and heme oxygenase-1 have been linked to energy homeostasis regulation more recently and the specific role of each one of them has not been fully elucidated. This mini review focuses on the above mentioned molecules and discusses them in relation to their regulation by the macronutrient composition of the diet as well as diet-induced weight loss. PMID:27469065

  17. Prognostic health monitoring in switch-mode power supplies with voltage regulation

    NASA Technical Reports Server (NTRS)

    Hofmeister, James P (Inventor); Judkins, Justin B (Inventor)

    2009-01-01

    The system includes a current injection device in electrical communication with the switch mode power supply. The current injection device is positioned to alter the initial, non-zero load current when activated. A prognostic control is in communication with the current injection device, controlling activation of the current injection device. A frequency detector is positioned to receive an output signal from the switch mode power supply and is able to count cycles in a sinusoidal wave within the output signal. An output device is in communication with the frequency detector. The output device outputs a result of the counted cycles, which are indicative of damage to an a remaining useful life of the switch mode power supply.

  18. Metabolic and genetic regulation of cardiac energy substrate preference.

    PubMed

    Kodde, Izaäk Frederik; van der Stok, Johan; Smolenski, Ryszard T; de Jong, Jan Willem

    2007-01-01

    Proper heart function relies on high efficiency of energy conversion. Mitochondrial oxygen-dependent processes transfer most of the chemical energy from metabolic substrates into ATP. Healthy myocardium uses mainly fatty acids as its major energy source, with little contribution of glucose. However, lactate, ketone bodies, amino acids or even acetate can be oxidized under certain circumstances. A complex interplay exists between various substrates responding to energy needs and substrate availability. The relative substrate concentration is the prime factor defining preference and utilization rate. Allosteric enzyme regulation and protein phosphorylation cascades, partially controlled by hormones such as insulin, modulate the concentration effect; together they provide short-term adjustments of cardiac energy metabolism. The expression of metabolic machinery genes is also dynamically regulated in response to developmental and (patho)physiological conditions, leading to long-term adjustments. Specific nuclear receptor transcription factors and co-activators regulate the expression of these genes. These include peroxisome proliferator-activated receptors and their nuclear receptor co-activator, estrogen-related receptor and hypoxia-inducible transcription factor 1. Increasing glucose and reducing fatty acid oxidation by metabolic regulation is already a target for effective drugs used in ischemic heart disease and heart failure. Interaction with genetic factors that control energy metabolism could provide even more powerful pharmacological tools.

  19. Is energy supply the trigger for reproductive activity in male edible dormice (Glis glis)?

    PubMed

    Fietz, Joanna; Kager, Timo; Schauer, Sebastian

    2009-10-01

    In edible dormice (Glis glis) reproduction is synchronised with the intermittent masting of the European beech (Fagus sylvatica). In years of mast failure dormouse males seem to anticipate future low food availability and fail to develop functional testes. We hypothesised that the availability of high-quality food is linked to male reproductive capacity, because of high male energetic demands during gonad maturation. We therefore evaluated the relationship between beech seed production and male reproductivity in the field between 1993 and 2005. In order to know whether the energy content of the food as such triggers sexual capacity, we supplemented high-quality food in the field for 3 years and investigated reproductive output, reproductive capacity, and body mass changes. Results revealed that male reproductive capacity was positively linked with beech seed production. Body mass changes of reference males during the high reproductive year further revealed high energetic demands of male reproduction, which were counter balanced in food-supplemented males. However, in contrast to our assumptions, artificial food supply during a year of mast failure failed to evoke high reproductivity in edible dormice. The availability of high-quality food can therefore be ruled out from being the primary trigger for sexual activity in male edible dormice.

  20. Limiting factors in photosynthesis. V. Photochemical energy supply colimits photosynthesis at low values of intercellular CO/sub 2/ concentration

    SciTech Connect

    Taylor, S.E.; Terry, N.

    1984-05-01

    Although there is now some agreement with the view that the supply of photochemical energy may influence photosynthetic rate (P) at high CO/sub 2/ pressures, it is less clear whether this limitation extends to P at low CO/sub 2/. This was investigated by measuring P per area as a function of the intercellular CO/sub 2/ concentration (C/sub i/) at different levels of photochemical energy supply. Changes in the latter were obtained experimentally by varying the level of irradiance to normal (Fe-sufficient) leaves of Beta vulgaris L. cv F58-554H1, and by varying photosynthetic electron transport capacity using leaves from Fe-deficient and Fe-sufficient plants. P and C/sub i/ were determined for attached sugar beet leaves using open flow gas exchange. The results suggest the P/area was colimited by the supply of photochemical energy at very low as well as high values of C/sub i/. Using the procedure developed by Perchorowicz et al., we investigated the effect or irradiance on ribulose bisphosphate carboxylase (RuBPCase) activation. The ratio of initial extractable activity to total inducible RuBPCase activity increased from 0.25 to 0.90 as leaf irradiance increased from 100 to 1500 microeinsteins photosynthetically active radiation per square meter per second. These data suggest that colimitation by photochemical energy supply at low C/sub i/ may be mediated via effects on RuBPCase activation.

  1. 78 FR 2392 - Allegheny Energy Supply, LLC; Notice of Intent To File License Application, Filing of Pre...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ... Energy Supply, LLC. e. Name of Project: Millville Hydroelectric. f. Location: On the Shenandoah River... must include on the first page, project name (Millville Hydroelectric Project) and ] number (P-2343-081... should meet at Millville Hydroelectric Project, on the Shenandoah River, WV. All participants...

  2. A proteomic study showing differential regulation of stress, redox regulation and peroxidase proteins by iron supply and the transcription factor FER.

    PubMed

    Brumbarova, Tzvetina; Matros, Andrea; Mock, Hans-Peter; Bauer, Petra

    2008-04-01

    Plants need to mobilize iron in the soil, and the basic helix-loop-helix transcription factor FER is a central regulator of iron acquisition in tomato roots. FER activity is controlled by iron supply. To analyse to what extent FER influences Fe-regulated protein expression, we investigated the root proteome of wild-type tomato, the fer mutant and a transgenic FER overexpression line under low-iron conditions versus sufficient and generous iron supply. The root proteomes were analysed by two-dimensional gel electrophoresis with three technical and three biological replicates. Statistical analysis identified 39 protein spots that were differentially regulated in selected pairwise comparisons of experimental conditions. Of these, 24 were correlated with expression clusters revealed by principal component analysis. The 39 protein spots were analysed by MALDI-TOF and nanoLC-MS/MS to deduce their possible functions. We investigated the functional representation in the identified expression clusters, and found that loss of FER function in iron-cultured plants mimicked an iron-deficiency status. The largest identified protein expression cluster was upregulated by iron deficiency and in the fer mutant. Two iron-regulated proteins required FER activity for induction by iron deficiency. Few proteins were suppressed by iron deficiency. The differentially expressed proteins belonged predominantly to the functional categories 'stress', 'redox regulation' and 'miscellaneous peroxidases'. Hence, we were able to identify distinct expression clusters of proteins with distinct functions.

  3. Resource limits and conversion efficiency with implications for climate change and California's energy supply

    NASA Astrophysics Data System (ADS)

    Croft, Gregory Donald

    There are two commonly-used approaches to modeling the future supply of mineral resources. One is to estimate reserves and compare the result to extraction rates, and the other is to project from historical time series of extraction rates. Perceptions of abundant oil supplies in the Middle East and abundant coal supplies in the United States are based on the former approach. In both of these cases, an approach based on historical production series results in a much smaller resource estimate than aggregate reserve numbers. This difference is not systematic; natural gas production in the United States shows a strong increasing trend even though modest reserve estimates have resulted in three decades of worry about the gas supply. The implication of a future decline in Middle East oil production is that the market for transportation fuels is facing major changes, and that alternative fuels should be analyzed in this light. Because the U.S. holds very large coal reserves, synthesizing liquid hydrocarbons from coal has been suggested as an alternative fuel supply. To assess the potential of this process, one has to look at both the resource base and the net efficiency. The three states with the largest coal production declines in the 1996 to 2006 period are among the top 5 coal reserve holders, suggesting that gross coal reserves are a poor indicator of future production. Of the three categories of coal reserves reported by the U.S. Energy Information Administration, reserves at existing mines is the narrowest category and is approximately the equivalent of proved developed oil reserves. By this measure, Wyoming has the largest coal reserves in the U.S., and it accounted for all of U.S. coal production growth over the 1996 to 2006 time period. In Chapter 2, multi-cycle Hubbert curve analysis of historical data of coal production from 1850 to 2007 demonstrates that U.S. anthracite and bituminous coal are past their production peak. This result contradicts estimates based

  4. Three new players in energy regulation: preptin, adropin and irisin.

    PubMed

    Aydin, Suleyman

    2014-06-01

    Homeostasis of energy is regulated by genetic factors, food intake, and energy expenditure. When energy input is greater than expenditure, the balance is positive, which can lead to weight gain and obesity. When the balance is negative, weight is lost. Regulation of this homeostasis is multi-factorial, involving many orexigenic (appetite-stimulating) and anorexigenic (appetite-suppressing) peptide hormones. Peripheral tissues are now known to be involved in weight regulation and research on its endocrine characteristics proceeds apace. Preptin with 34 amino acids (MW 3948 Da), adropin with 43 amino acids and a molecular weight of (4999 Da), and irisin with 112 amino acids (12587 Da), are three newly discovered peptides critical for regulating energy metabolism. Preptin is synthesized primarily in pancreatic beta cells, and adropin mainly in the liver and brain, and many peripheral tissues. Irisin, however, is synthesized principally in the heart muscle, along with peripheral tissues, including salivary glands, kidney and liver. The prime functions of preptin and adropin include regulating carbohydrate, lipid and protein metabolisms by moderating glucose-mediated insulin release. Irisin is an anti-obesitic and anti-diabetic hormone regulating adipose tissue metabolism and glucose homeostasis by converting white to brown adipose tissue. This review offers a historical account of these discovery and function of these peptides, including their structure, and physiological and biochemical properties. Their roles in energy regulation will be discussed. Their measurement in biological fluids will be considered, which will lead to further discussion of their possible clinical value. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Designing Performance Measurement For Supply Chain's Actors And Regulator Using Scale Balanced Scorecard And Data Envelopment Analysis

    NASA Astrophysics Data System (ADS)

    Kusrini, Elisa; Subagyo; Aini Masruroh, Nur

    2016-01-01

    This research is a sequel of the author's earlier conducted researches in the fields of designing of integrated performance measurement between supply chain's actors and regulator. In the previous paper, the design of performance measurement is done by combining Balanced Scorecard - Supply Chain Operation Reference - Regulator Contribution model and Data Envelopment Analysis. This model referred as B-S-Rc-DEA model. The combination has the disadvantage that all the performance variables have the same weight. This paper investigates whether by giving weight to performance variables will produce more sensitive performance measurement in detecting performance improvement. Therefore, this paper discusses the development of the model B-S-Rc-DEA by giving weight to its performance'variables. This model referred as Scale B-S-Rc-DEA model. To illustrate the model of development, some samples from small medium enterprises of leather craft industry supply chain in province of Yogyakarta, Indonesia are used in this research. It is found that Scale B-S-Rc-DEA model is more sensitive to detecting performance improvement than B-S- Rc-DEA model.

  6. On the integration of wind and solar energy to provide a total energy supply in the USA

    NASA Astrophysics Data System (ADS)

    Archer, Cristina; Mills, David; Cheng, Weili; Sloggy, Matthew; Liebig, Edwin; Rhoades, Alan

    2010-05-01

    This study examines the feasibility of using renewable energy - mostly wind and solar radiation - as the primary source of energy in the USA, under the assumption that a nationwide electric transmission grid is in place. Previous studies have shown that solar or wind alone can power the present U.S. grid on average. Other studies have shown that solar output from California and Texas using energy storage is well correlated with the state energy load on an hour by hour basis throughout the year and with the U.S. national load on a monthly basis. This study explores scenarios for use of wind and solar energy together at the national scale on an hour by hour basis to determine if such a combination is a better match to national seasonal load scenarios than either of the two alone on an hour-by-hour basis. Actual hour by hour national load data from the year 2006 are used as a basis, with some scenarios incorporating vehicle sector electrification and building heating and cooling using electric heat pumps. Hourly wind speed data were calculated at the hub height of 80 m above the ground for the year 2006 at over 150 windy locations in the continental U.S. using an extrapolation technique based on 10-m wind speed measurements and vertical sounding profiles. Using a 1.5 MW wind turbine as benchmark, the hourly wind power production nationwide was determined at all suitable locations. Similarly, the hourly output from solar plants, with and without thermal storage, was calculated based on Ausra's model assuming that the solar production would occur in the Southwest, the area with the greatest solar radiation density in the U.S. Hourly electricity demand for the year 2006 was obtained nationwide from a variety of sources, including the Federal Energy Regulation Commission. Hourly residential heating and cooking, industrial heat processing, and future electrified transportation loads were calculated from monthly and yearly energy consumption data from the Energy Information

  7. Designing Energy Supply Chains with the P-graph Framework under Cost Constraints and Sustainability Considerations

    EPA Science Inventory

    A computer-aided methodology for designing sustainable supply chains is presented using the P-graph framework to develop supply chain structures which are analyzed using cost, the cost of producing electricity, and two sustainability metrics: ecological footprint and emergy. They...

  8. Designing Energy Supply Chains with the P-graph Framework under Cost Constraints and Sustainability Considerations

    EPA Science Inventory

    A computer-aided methodology for designing sustainable supply chains is presented using the P-graph framework to develop supply chain structures which are analyzed using cost, the cost of producing electricity, and two sustainability metrics: ecological footprint and emergy. They...

  9. Japan's Long-term Energy Demand and Supply Scenario to 2050 - Estimation for the Potential of Massive CO2 Mitigation

    SciTech Connect

    Komiyama, Ryoichi; Marnay, Chris; Stadler, Michael; Lai, Judy; Borgeson, Sam; Coffey, Brian; Azevedo, Ines Lima

    2009-09-01

    In this analysis, the authors projected Japan's energy demand/supply and energy-related CO{sub 2} emissions to 2050. Their analysis of various scenarios indicated that Japan's CO{sub 2} emissions in 2050 could be potentially reduced by 26-58% from the current level (FY 2005). These results suggest that Japan could set a CO{sub 2} emission reduction target for 2050 at between 30% and 60%. In order to reduce CO{sub 2} emissions by 60% in 2050 from the present level, Japan will have to strongly promote energy conservation at the same pace as an annual rate of 1.9% after the oil crises (to cut primary energy demand per GDP (TPES/GDP) in 2050 by 60% from 2005) and expand the share of non-fossil energy sources in total primary energy supply in 2050 to 50% (to reduce CO{sub 2} emissions per primary energy demand (CO{sub 2}/TPES) in 2050 by 40% from 2005). Concerning power generation mix in 2050, nuclear power will account for 60%, solar and other renewable energy sources for 20%, hydro power for 10% and fossil-fired generation for 10%, indicating substantial shift away from fossil fuel in electric power supply. Among the mitigation measures in the case of reducing CO{sub 2} emissions by 60% in 2050, energy conservation will make the greatest contribution to the emission reduction, being followed by solar power, nuclear power and other renewable energy sources. In order to realize this massive CO{sub 2} abatement, however, Japan will have to overcome technological and economic challenges including the large-scale deployment of nuclear power and renewable technologies.

  10. Moving from self-regulation to external regulation of Department of Energy facilities

    SciTech Connect

    Wishau, R.J.; Dawson, J.; Lee, D.W.

    1999-03-01

    This paper discusses the initiative to transfer the regulation of Department of Energy (DOE) nuclear facilities to the US Nuclear Regulatory Commission (NRC). The paper gives an overview of some of the major technical, policy and legal issues that accompany this initiative. The paper focuses on specific issues and how they may be affected by external regulation of occupational radiation protection at DOE facilities. Differences between the NRC and the DOE approach to regulating nuclear safety are compared and contrasted. Some projected impacts from this transition are examined. Finally, recommendations are provided that may enhance the transition, increasing the likelihood of successful external NRC regulation.

  11. Structuring energy supply and demand networks in a general equilibrium model to simulate global warming control strategies

    SciTech Connect

    Hamilton, S.; Veselka, T.D.; Cirillo, R.R.

    1991-01-01

    Global warming control strategies which mandate stringent caps on emissions of greenhouse forcing gases can substantially alter a country's demand, production, and imports of energy products. Although there is a large degree of uncertainty when attempting to estimate the potential impact of these strategies, insights into the problem can be acquired through computer model simulations. This paper presents one method of structuring a general equilibrium model, the ENergy and Power Evaluation Program/Global Climate Change (ENPEP/GCC), to simulate changes in a country's energy supply and demand balance in response to global warming control strategies. The equilibrium model presented in this study is based on the principle of decomposition, whereby a large complex problem is divided into a number of smaller submodules. Submodules simulate energy activities and conversion processes such as electricity production. These submodules are linked together to form an energy supply and demand network. Linkages identify energy and fuel flows among various activities. Since global warming control strategies can have wide reaching effects, a complex network was constructed. The network represents all energy production, conversion, transportation, distribution, and utilization activities. The structure of the network depicts interdependencies within and across economic sectors and was constructed such that energy prices and demand responses can be simulated. Global warming control alternatives represented in the network include: (1) conservation measures through increased efficiency; and (2) substitution of fuels that have high greenhouse gas emission rates with fuels that have lower emission rates. 6 refs., 4 figs., 4 tabs.

  12. Regulation of energy balance and body weight by the brain: a distributed system prone to disruption.

    PubMed

    Faulconbridge, Lucy F; Hayes, Matthew R

    2011-12-01

    Maintaining adequate energy supply via regulation of food intake and energy expenditure is crucial for survival and reproduction. The neural control of energy balance is highly complex, occurs across distributed central and peripheral areas, and incorporates multiple domains of control (including homeostatic and hedonic processes). The sheer number of active compounds (such as leptin and GLP-1) involved in the regulation of food intake speaks to the redundancy and complexity of the system. The balance between energy intake and expenditure is under CNS control. Constant bidirectional communication between the brain and the GI tract, as well as between the brain and other relevant tissues (ie, adipose tissue, pancreas, and liver), ensures that the brain constantly perceives and responds accordingly to the energy status/needs of the body. This elegant biological system is subject to disruption by a toxic obesogenic environment, leading to syndromes such as leptin and insulin resistance, and ultimately further exposing obese individuals to further weight gain and T2DM. Recent imaging studies in humans are beginning to examine the influence that higher-order/hedonic brain regions have on homeostatic areas, as well as their responsiveness to homeostatic peripheral signals. With greater understanding of these mechanisms, the field moves closer to understanding and eventually treating the causalities of obesity.

  13. A proposed national wind power R and D program. [offshore wind power system for electric energy supplies

    NASA Technical Reports Server (NTRS)

    Heronemus, W.

    1973-01-01

    An offshore wind power system is described that consists of wind driven electrical dc generators mounted on floating towers in offshore waters. The output from the generators supplies underwater electrolyzer stations in which water is converted into hydrogen and oxygen. The hydrogen is piped to shore for conversion to electricity in fuel cell stations. It is estimated that this system can produce 159 x 10 to the ninth power kilowatt-hours per year. It is concluded that solar energy - and that includes wind energy - is the only way out of the US energy dilemma in the not too distant future.

  14. Marine Hydrokinetic Energy Regulators Workshop: Lessons from Wind

    SciTech Connect

    Baring-Gould, E. Ian

    2015-09-03

    Ian Baring-Gould presented these lessons learned from wind energy to an audience of marine hydrokinetic regulators. Lessons learned spanned the areas of technology advances, using collaborative approaches to involve key stakeholders; using baseline studies to measure and prioritize wildlife impacts, and look at avoidance and mitigation options early in the process.

  15. Polyphosphate - an ancient energy source and active metabolic regulator

    PubMed Central

    2011-01-01

    There are a several molecules on Earth that effectively store energy within their covalent bonds, and one of these energy-rich molecules is polyphosphate. In microbial cells, polyphosphate granules are synthesised for both energy and phosphate storage and are degraded to produce nucleotide triphosphate or phosphate. Energy released from these energetic carriers is used by the cell for production of all vital molecules such as amino acids, nucleobases, sugars and lipids. Polyphosphate chains directly regulate some processes in the cell and are used as phosphate donors in gene regulation. These two processes, energetic metabolism and regulation, are orchestrated by polyphosphate kinases. Polyphosphate kinases (PPKs) can currently be categorized into three groups (PPK1, PPK2 and PPK3) according their functionality; they can also be divided into three groups according their homology (EcPPK1, PaPPK2 and ScVTC). This review discusses historical information, similarities and differences, biochemical characteristics, roles in stress response regulation and possible applications in the biotechnology industry of these enzymes. At the end of the review, a hypothesis is discussed in view of synthetic biology applications that states polyphosphate and calcium-rich organelles have endosymbiotic origins from ancient protocells that metabolized polyphosphate. PMID:21816086

  16. Information Integration and Energy Expenditure in Gene Regulation.

    PubMed

    Estrada, Javier; Wong, Felix; DePace, Angela; Gunawardena, Jeremy

    2016-06-30

    The quantitative concepts used to reason about gene regulation largely derive from bacterial studies. We show that this bacterial paradigm cannot explain the sharp expression of a canonical developmental gene in response to a regulating transcription factor (TF). In the absence of energy expenditure, with regulatory DNA at thermodynamic equilibrium, information integration across multiple TF binding sites can generate the required sharpness, but with strong constraints on the resultant "higher-order cooperativities." Even with such integration, there is a "Hopfield barrier" to sharpness; for n TF binding sites, this barrier is represented by the Hill function with the Hill coefficient n. If, however, energy is expended to maintain regulatory DNA away from thermodynamic equilibrium, as in kinetic proofreading, this barrier can be breached and greater sharpness achieved. Our approach is grounded in fundamental physics, leads to testable experimental predictions, and suggests how a quantitative paradigm for eukaryotic gene regulation can be formulated.

  17. Regulation of energy metabolism by the skeleton: osteocalcin and beyond.

    PubMed

    Ferron, Mathieu; Lacombe, Julie

    2014-11-01

    The skeleton has recently emerged as an endocrine organ implicated in the regulation of glucose and energy metabolism. This function of bone is mediated, at least in part, by osteocalcin, an osteoblast-derived protein acting as a hormone stimulating insulin sensitivity, insulin secretion and energy expenditure. Osteocalcin secretion and bioactivity is in turn regulated by several hormonal cues including insulin, leptin, the sympathetic nervous system and glucocorticoids. Recent findings support the notion that osteocalcin functions and regulations are conserved between mice and humans. Moreover, studies in mice suggest that osteocalcin could represent a viable therapeutic approach for the treatment of obesity and insulin resistance. In this review, we summarize the current knowledge on osteocalcin functions, its various modes of action and the mechanisms implicated in the control of this hormone.

  18. Economic growth and energy regulation in the environmental Kuznets curve.

    PubMed

    Lorente, Daniel Balsalobre; Álvarez-Herranz, Agustín

    2016-08-01

    This study establishes the existence of a pattern of behavior, between economic growth and environmental degradation, consistent with the environmental Kuznets curve (EKC) hypothesis for 17 Organization for Economic Cooperation and Development (OECD) countries between 1990 and 2012. Based on this EKC pattern, it shows that energy regulation measures help reduce per capita greenhouse gas (GHG) emissions. To validate this hypothesis, we also add the explanatory variables: renewable energy promotion, energy innovation processes, and the suppression effect of income level on the contribution of renewable energy sources to total energy consumption. It aims to be a tool for decision-making regarding energy policy. This paper provides a two-stage econometric analysis of instrumental variables with the aim of correcting the existence of endogeneity in the variable GDP per capita, verifying that the instrumental variables used in this research are appropriate for our aim. To this end, it first makes a methodological contribution before incorporating additional variables associated with environmental air pollution into the EKC hypothesis and showing how they positively affect the explanation of the correction in the GHG emission levels. This study concludes that air pollution will not disappear on its own as economic growth increases. Therefore, it is necessary to promote energy regulation measures to reduce environmental pollution.

  19. Benefits from flywheel energy storage for area regulation in California - demonstration results : a study for the DOE Energy Storage Systems program.

    SciTech Connect

    Eyer, James M.

    2009-10-01

    This report documents a high-level analysis of the benefit and cost for flywheel energy storage used to provide area regulation for the electricity supply and transmission system in California. Area regulation is an 'ancillary service' needed for a reliable and stable regional electricity grid. The analysis was based on results from a demonstration, in California, of flywheel energy storage developed by Beacon Power Corporation (the system's manufacturer). Demonstrated was flywheel storage systems ability to provide 'rapid-response' regulation. Flywheel storage output can be varied much more rapidly than the output from conventional regulation sources, making flywheels more attractive than conventional regulation resources. The performance of the flywheel storage system demonstrated was generally consistent with requirements for a possible new class of regulation resources - 'rapid-response' energy-storage-based regulation - in California. In short, it was demonstrated that Beacon Power Corporation's flywheel system follows a rapidly changing control signal (the ACE, which changes every four seconds). Based on the results and on expected plant cost and performance, the Beacon Power flywheel storage system has a good chance of being a financially viable regulation resource. Results indicate a benefit/cost ratio of 1.5 to 1.8 using what may be somewhat conservative assumptions. A benefit/cost ratio of one indicates that, based on the financial assumptions used, the investment's financial returns just meet the investors target.

  20. AMPK and the neuroendocrine regulation of appetite and energy expenditure.

    PubMed

    Stark, Romana; Ashley, Sarah E; Andrews, Zane B

    2013-02-25

    This review highlights recent advances in the hormonal control of hypothalamic AMPK activity and the impact on appetite and energy metabolism. AMPK is an intracellular energy sensor that switches off ATP-consuming pathways and switches on ATP-producing pathways such as glucose uptake and fatty acid oxidation. In this regard, it is well positioned to respond to dynamic changes in metabolic state and nutritional over- or under-supply. Within the hypothalamus, AMPK responds to peripheral hormones that convey metabolic information based on increased plasma concentrations. For example, negative energy balance increases plasma ghrelin concentrations, increases hypothalamic AMPK and drives food intake. Conversely, plasma leptin concentrations are secreted in proportion to adipose levels and leptin suppresses hypothalamic AMPK activity and restricts food intake. This review explains that hypothalamic AMPK mediates neuroendocrine feedback control of energy metabolism. A current working model suggests that endocrine feedback influences hypothalamic AMPK via a number of mechanisms designed to shift an organism from negative to neutral energy balance. These mechanisms include (1) ghrelin stimulation of AMPK in NPY/AgRP in the arcuate nucleus (2) ghrelin stimulation of AMPK in the ventromedial hypothalamic nucleus, (3) a novel ghrelin-stimulated AMPK-dependent presynaptic mechanism that sustains AgRP neuron firing via a local synaptic memory system, (4) adiponectin stimulation of hypothalamic AMPK and (5) hypothalamic AMPK control of energy expenditure by thyroid hormone or leptin. The number of diverse mechanisms ensures hypothalamic AMPK drives the shift from negative to neutral energy balance and underscores the fundamental importance of hypothalamic AMPK to maintain neutral energy balance. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  1. Regionalized LCA-based optimization of building energy supply: method and case study for a Swiss municipality.

    PubMed

    Saner, Dominik; Vadenbo, Carl; Steubing, Bernhard; Hellweg, Stefanie

    2014-07-01

    This paper presents a regionalized LCA-based multiobjective optimization model of building energy demand and supply for the case of a Swiss municipality for the minimization of greenhouse gas emissions and particulate matter formation. The results show that the environmental improvement potential is very large: in the optimal case, greenhouse gas emissions from energy supply could be reduced by more than 75% and particulate emissions by over 50% in the municipality. This scenario supposes a drastic shift of heat supply systems from a fossil fuel dominated portfolio to a portfolio consisting of mainly heat pump and woodchip incineration systems. In addition to a change in heat supply technologies, roofs, windows and walls would need to be refurbished in more than 65% of the municipality's buildings. The full potential of the environmental impact reductions will hardly be achieved in reality, particularly in the short term, for example, because of financial constraints and social acceptance, which were not taken into account in this study. Nevertheless, the results of the optimization model can help policy makers to identify the most effective measures for improvement at the decision making level, for example, at the building level for refurbishment and selection of heating systems or at the municipal level for designing district heating networks. Therefore, this work represents a starting point for designing effective incentives to reduce the environmental impact of buildings. While the results of the optimization model are specific to the municipality studied, the model could readily be adapted to other regions.

  2. 10 CFR 603.1330 - Supplies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Supplies. 603.1330 Section 603.1330 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in... a useful life of less than one year or an acquisition cost of less than $5,000 per unit. ...

  3. 10 CFR 603.1330 - Supplies.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Supplies. 603.1330 Section 603.1330 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in... a useful life of less than one year or an acquisition cost of less than $5,000 per unit. ...

  4. 10 CFR 603.1330 - Supplies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Supplies. 603.1330 Section 603.1330 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in... a useful life of less than one year or an acquisition cost of less than $5,000 per unit. ...

  5. 10 CFR 603.1330 - Supplies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Supplies. 603.1330 Section 603.1330 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Definitions of Terms Used in... a useful life of less than one year or an acquisition cost of less than $5,000 per unit. ...

  6. 75 FR 11841 - Proposed Information Collection; Comment Request; Short Supply Regulations, Petroleum (Crude Oil)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... Regulations, Petroleum (Crude Oil) AGENCY: Bureau of Industry and Security. ACTION: Notice. SUMMARY: The... petroleum (crude oil) and is used by licensing officers to determine the exporter's compliance with the five...

  7. 78 FR 5448 - Federal Acquisition Regulation; Submission for OMB Review; Economic Purchase Quantity-Supplies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... for the proper performance of functions of the Federal Acquisition Regulation (FAR), and whether it... Secretariat (MVCB), 1275 First Street NE., Washington, DC 20417. ATTN: Hada Flowers/IC 9000-0082, Economic...

  8. FOXO1 in the ventromedial hypothalamus regulates energy balance.

    PubMed

    Kim, Ki Woo; Donato, Jose; Berglund, Eric D; Choi, Yun-Hee; Kohno, Daisuke; Elias, Carol F; Depinho, Ronald A; Elmquist, Joel K

    2012-07-01

    The transcription factor FOXO1 plays a central role in metabolic homeostasis by regulating leptin and insulin activity in many cell types, including neurons. However, the neurons mediating these effects and the identity of the molecular targets through which FOXO1 regulates metabolism remain to be defined. Here, we show that the ventral medial nucleus of the hypothalamus (VMH) is a key site of FOXO1 action. We found that mice lacking FOXO1 in steroidogenic factor 1 (SF-1) neurons of the VMH are lean due to increased energy expenditure. The mice also failed to appropriately suppress energy expenditure in response to fasting. Furthermore, these mice displayed improved glucose tolerance due to increased insulin sensitivity in skeletal muscle and heart. Gene expression profiling and sequence analysis revealed several pathways regulated by FOXO1. In addition, we identified the nuclear receptor SF-1 as a direct FOXO1 transcriptional target in the VMH. Collectively, our data suggest that the transcriptional networks modulated by FOXO1 in VMH neurons are key components in the regulation of energy balance and glucose homeostasis.

  9. FOXO1 in the ventromedial hypothalamus regulates energy balance

    PubMed Central

    Kim, Ki Woo; Donato, Jose; Berglund, Eric D.; Choi, Yun-Hee; Kohno, Daisuke; Elias, Carol F.; DePinho, Ronald A.; Elmquist, Joel K.

    2012-01-01

    The transcription factor FOXO1 plays a central role in metabolic homeostasis by regulating leptin and insulin activity in many cell types, including neurons. However, the neurons mediating these effects and the identity of the molecular targets through which FOXO1 regulates metabolism remain to be defined. Here, we show that the ventral medial nucleus of the hypothalamus (VMH) is a key site of FOXO1 action. We found that mice lacking FOXO1 in steroidogenic factor 1 (SF-1) neurons of the VMH are lean due to increased energy expenditure. The mice also failed to appropriately suppress energy expenditure in response to fasting. Furthermore, these mice displayed improved glucose tolerance due to increased insulin sensitivity in skeletal muscle and heart. Gene expression profiling and sequence analysis revealed several pathways regulated by FOXO1. In addition, we identified the nuclear receptor SF-1 as a direct FOXO1 transcriptional target in the VMH. Collectively, our data suggest that the transcriptional networks modulated by FOXO1 in VMH neurons are key components in the regulation of energy balance and glucose homeostasis. PMID:22653058

  10. Controlling a transonic flow around airfoils by means of energy supply with allowance for real properties of air

    NASA Astrophysics Data System (ADS)

    Aulchenko, S. M.; Zamuraev, V. P.; Kalinina, A. P.

    2010-05-01

    The influence of molecular (thermodynamic and transport) properties of air on gas-dynamic effects of pulsed-periodic energy supply in a transonic flow around airfoils is studied. Relations for air with allowance for excitation of vibrations and dissociation are taken as the thermal equation of state and the caloric equation. The influence of the transport properties (viscosity) is taken into account approximately, within the framework of the boundary layer model. It is demonstrated that the effects in qualitative considerations do not depend on taking into account the molecular properties, but the allowance for internal degrees of freedom yields a significantly lower temperature than the temperature predicted by the ideal gas model. Allowance for viscosity ensures certain attenuation of the energy supply effects.

  11. Role of Erythrocyte-released ATP in the Regulation of Microvascular Oxygen Supply in Skeletal Muscle

    PubMed Central

    Ellsworth, Mary L.; Ellis, Christopher G.; Sprague, Randy S.

    2015-01-01

    In a 1914 book entitled The Respiratory Function of the Blood, Joseph Barcroft stated that “the cell takes what it needs and leaves the rest.” He postulated that there must be both a “call for oxygen” and a “mechanism by which the call elicits a response…” In the past century, intensive investigation has provided significant insights into the hemodynamic and biophysical mechanisms involved in supplying oxygen to skeletal muscle. However, the identification of the mechanism by which tissue oxygen needs are sensed and the affector responsible for altering the upstream vasculature to enable the need to be appropriately met has been a challenge. In 1995, Ellsworth et al proposed that the oxygen carrying erythrocyte, by virtue of its capacity to release the vasoactive mediator ATP in response to a decrease in oxygen saturation, could serve both roles. Several in vitro and in situ studies have established that exposure of erythrocytes to reduced oxygen tension induces the release of ATP which does result in a conducted arteriolar vasodilation with a sufficiently rapid time course to make the mechanism physiologically relevant. The components of the signaling pathway for the controlled release of ATP from erythrocytes in response to exposure to low oxygen tension have been determined. In addition, the implications of defective ATP release on human pathological conditions have been explored. This review provides a perspective on oxygen supply and the role that such a mechanism plays in meeting the oxygen needs of skeletal muscle. PMID:26336065

  12. Role of erythrocyte-released ATP in the regulation of microvascular oxygen supply in skeletal muscle.

    PubMed

    Ellsworth, M L; Ellis, C G; Sprague, R S

    2016-03-01

    In a 1914 book entitled The Respiratory Function of the Blood, Joseph Barcroft stated that 'the cell takes what it needs and leaves the rest'. He postulated that there must be both a 'call for oxygen' and a 'mechanism by which the call elicits a response...' In the past century, intensive investigation has provided significant insights into the haemodynamic and biophysical mechanisms involved in supplying oxygen to skeletal muscle. However, the identification of the mechanism by which tissue oxygen needs are sensed and the affector responsible for altering the upstream vasculature to enable the need to be appropriately met has been a challenge. In 1995, Ellsworth et al. proposed that the oxygen-carrying erythrocyte, by virtue of its capacity to release the vasoactive mediator ATP in response to a decrease in oxygen saturation, could serve both roles. Several in vitro and in situ studies have established that exposure of erythrocytes to reduced oxygen tension induces the release of ATP which does result in a conducted arteriolar vasodilation with a sufficiently rapid time course to make the mechanism physiologically relevant. The components of the signalling pathway for the controlled release of ATP from erythrocytes in response to exposure to low oxygen tension have been determined. In addition, the implications of defective ATP release on human pathological conditions have been explored. This review provides a perspective on oxygen supply and the role that such a mechanism plays in meeting the oxygen needs of skeletal muscle.

  13. Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation

    PubMed Central

    Guzun, R.; Kaambre, T.; Bagur, R.; Grichine, A.; Usson, Y.; Varikmaa, M.; Anmann, T.; Tepp, K.; Timohhina, N.; Shevchuk, I.; Chekulayev, V.; Boucher, F.; Santos, P. Dos; Schlattner, U.; Wallimann, T.; Kuznetsov, A. V.; Dzeja, P.; Aliev, M.; Saks, V.

    2014-01-01

    To meet high cellular demands, the energy metabolism of cardiac muscles is organized by precise and coordinated functioning of intracellular energetic units (ICEUs). ICEUs represent structural and functional modules integrating multiple fluxes at sites of ATP generation in mitochondria and ATP utilization by myofibrillar, sarcoplasmic reticulum and sarcolemma ion-pump ATPases. The role of ICEUs is to enhance the efficiency of vectorial intracellular energy transfer and fine tuning of oxidative ATP synthesis maintaining stable metabolite levels to adjust to intracellular energy needs through the dynamic system of compartmentalized phosphoryl transfer networks. One of the key elements in regulation of energy flux distribution and feedback communication is the selective permeability of mitochondrial outer membrane (MOM) which represents a bottleneck in adenine nucleotide and other energy metabolite transfer and microcompartmentalization. Based on the experimental and theoretical (mathematical modelling) arguments, we describe regulation of mitochondrial ATP synthesis within ICEUs allowing heart workload to be linearly correlated with oxygen consumption ensuring conditions of metabolic stability, signal communication and synchronization. Particular attention was paid to the structure–function relationship in the development of ICEU, and the role of mitochondria interaction with cytoskeletal proteins, like tubulin, in the regulation of MOM permeability in response to energy metabolic signals providing regulation of mitochondrial respiration. Emphasis was given to the importance of creatine metabolism for the cardiac energy homoeostasis. PMID:24666671

  14. Evolving Role of the Power Sector Regulator: A Clean Energy Regulators Initiative Report

    SciTech Connect

    Zinaman, O.; Miller, M.; Bazilian, M.

    2014-04-01

    This paper seeks to briefly characterize the evolving role of power sector regulation. Given current global dynamics, regulation of the power sector is undergoing dramatic changes. This transformation is being driven by various factors including technological advances and cost reductions in renewable energy, energy efficiency, and demand management; increasing air pollution and climate change concerns; and persistent pressure for ensuring sustainable economic development and increased access to energy services by the poor. These issues add to the already complex task of power sector regulation, of which the fundamental remit remains to objectively and transparently ensure least-cost service delivery at high quality. While no single regulatory task is trivial to undertake, it is the prioritization and harmonization of a multitude of objectives that exemplifies the essential challenge of power sector regulation. Evolving regulatory roles can be understood through the concept of existing objectives and an additional layer of emerging objectives. Following this categorization, we describe seven existing objectives of power sector regulators and nine emerging objectives, highlighting key challenges and outlining interdependencies. This essay serves as a preliminary installment in the Clean Energy Regulatory Initiative (CERI) series, and aims to lay the groundwork for subsequent reports and case studies that will explore these topics in more depth.

  15. Dcf1 regulates neuropeptide expression and maintains energy balance.

    PubMed

    Liu, Qiang; Chen, Yu; Li, Qian; Wu, Liang; Wen, Tieqiao

    2017-05-22

    Neuropeptide Y (NPY) is an important neurotransmitter in the brain that plays a pivotal role in food intake and energy storage. Although many studies have focused on these functions, the regulation of NPY expression remains unclear. Here we showed that dendritic cell factor 1 (Dcf1) regulates NPY expression and maintains energy balance. We found that NPY expression is significantly reduced in the hypothalamus of Dcf1 knockout (Dcf1(-/-), KO) mice. In contrast, Dcf1 overexpression significantly increases NPY expression in the cell line. We also found that Dcf1 acts upstream of the NPY gene to regulate NPY expression and modulates the NPY-NPY receptor 1-GABA signal. Notably, we observed a significant increase in the ATP concentration in Dcf1(-/-) mice, suggesting a greater demand for energy in the absence of Dcf1. We studied the relationship between Dcf1 and NPY and revealed that Dcf1 plays a critical role in energy balance. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Brain regulation of energy balance and body weight.

    PubMed

    Rui, Liangyou

    2013-12-01

    Body weight is determined by a balance between food intake and energy expenditure. Multiple neural circuits in the brain have evolved to process information about food, food-related cues and food consumption to control feeding behavior. Numerous gastrointestinal endocrine cells produce and secrete satiety hormones in response to food consumption and digestion. These hormones suppress hunger and promote satiation and satiety mainly through hindbrain circuits, thus governing meal-by-meal eating behavior. In contrast, the hypothalamus integrates adiposity signals to regulate long-term energy balance and body weight. Distinct hypothalamic areas and various orexigenic and anorexigenic neurons have been identified to homeostatically regulate food intake. The hypothalamic circuits regulate food intake in part by modulating the sensitivity of the hindbrain to short-term satiety hormones. The hedonic and incentive properties of foods and food-related cues are processed by the corticolimbic reward circuits. The mesolimbic dopamine system encodes subjective "liking" and "wanting" of palatable foods, which is subjected to modulation by the hindbrain and the hypothalamic homeostatic circuits and by satiety and adiposity hormones. Satiety and adiposity hormones also promote energy expenditure by stimulating brown adipose tissue (BAT) activity. They stimulate BAT thermogenesis mainly by increasing the sympathetic outflow to BAT. Many defects in satiety and/or adiposity hormone signaling and in the hindbrain and the hypothalamic circuits have been described and are believed to contribute to the pathogenesis of energy imbalance and obesity.

  17. Preliminary investigation on a primary energy saving heat supply system for the residential district "Maria Lindenhof" in Dorsten, West Germany

    NASA Astrophysics Data System (ADS)

    Bechtel, A.; Berlinghoff, K.; Grossmann, H.; Kaschube, H.; Reinmuth, F.

    1980-12-01

    Ways and means to operate a heating station by gas motor-driven heat pumps, using river water as heat source are investigated. The economic viability of the scheme is considered. A comparison with conventional technologies clearly shows the feasibility and effectiveness of this application, and at the same time supplies guidelines for design and dimensioning. Because of possible energy saving, the present investigation supports the realization of the project.

  18. Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply

    PubMed Central

    Ask, Katrine; Jasencakova, Zuzana; Menard, Patrice; Feng, Yunpeng; Almouzni, Geneviève; Groth, Anja

    2012-01-01

    Efficient supply of new histones during DNA replication is critical to restore chromatin organization and maintain genome function. The histone chaperone anti-silencing function 1 (Asf1) serves a key function in providing H3.1-H4 to CAF-1 for replication-coupled nucleosome assembly. We identify Codanin-1 as a novel interaction partner of Asf1 regulating S-phase histone supply. Mutations in Codanin-1 can cause congenital dyserythropoietic anaemia type I (CDAI), characterized by chromatin abnormalities in bone marrow erythroblasts. Codanin-1 is part of a cytosolic Asf1–H3.1-H4–Importin-4 complex and binds directly to Asf1 via a conserved B-domain, implying a mutually exclusive interaction with the chaperones CAF-1 and HIRA. Codanin-1 depletion accelerates the rate of DNA replication and increases the level of chromatin-bound Asf1, suggesting that Codanin-1 guards a limiting step in chromatin replication. Consistently, ectopic Codanin-1 expression arrests S-phase progression by sequestering Asf1 in the cytoplasm, blocking histone delivery. We propose that Codanin-1 acts as a negative regulator of Asf1 function in chromatin assembly. This function is compromised by two CDAI mutations that impair complex formation with Asf1, providing insight into the molecular basis for CDAI disease. PMID:22407294

  19. Energy II: Use, Conservation and Supply. No. 6 in a Series of Special "Science" Compendia.

    ERIC Educational Resources Information Center

    Abelson, Philip H., Ed.; Hammond, Allen L., Ed.

    Presented are 26 articles originally published in "Science" during 1975-78. The document is divided into three parts. The first part contains articles on changes in energy use. Included are articles on industrial energy use, energy options and strategies for Western Europe, energy use in Brazil, and solar energy for village development, as well as…

  20. Energy II: Use, Conservation and Supply. No. 6 in a Series of Special "Science" Compendia.

    ERIC Educational Resources Information Center

    Abelson, Philip H., Ed.; Hammond, Allen L., Ed.

    Presented are 26 articles originally published in "Science" during 1975-78. The document is divided into three parts. The first part contains articles on changes in energy use. Included are articles on industrial energy use, energy options and strategies for Western Europe, energy use in Brazil, and solar energy for village development, as well as…

  1. Energy balance regulation by thyroid hormones at central level.

    PubMed

    López, Miguel; Alvarez, Clara V; Nogueiras, Rubén; Diéguez, Carlos

    2013-07-01

    Classically, medical textbooks taught that most effects of thyroid hormones (THs) on energy homeostasis are directly exerted in peripheral tissues. However, current evidence is changing (and challenging) our perspective about the role of THs from a 'peripheral' to a 'central' vision, implying that they affect food intake, energy expenditure, and metabolism by acting, to a large extent, at the central level. Interestingly, effects of THs are interrelated with global energy sensors in the central nervous system (CNS), such as uncoupling protein 2 (UCP2), AMP-activated protein kinase (AMPK; the 'AMPK-BAT axis'), and mechanistic target of rapamycin (mTOR). Here, we review what is currently known about THs and their regulation of energy balance and metabolism in both peripheral and central tissues.

  2. Impact of active and break wind spells on the demand-supply balance in wind energy in India

    NASA Astrophysics Data System (ADS)

    Kulkarni, Sumeet; Deo, M. C.; Ghosh, Subimal

    2017-01-01

    With an installed capacity of over 19,000 MW, the wind power currently accounts for almost 70% of the total installed capacity among the renewable energy sector in India. The extraction of wind power mainly depends on prevailing meteorology which is strongly influenced by monsoon variability. The monsoon season is characterized by significant fluctuations in between periods of wet and dry spells. During the dry spells, the demand for power from agriculture and cooling equipment increases, whereas during the wet periods, such demand reduces, although, at the same time, the power supply increases because of strong westerly winds contributing to an enhanced production of wind energy. At this backdrop, we aim to assess the impact of intra-seasonal wind variability on the balance of energy supply and demand during monsoon seasons in India. Further, we explore the probable cause of wind variability by relating it to El Nino events. It is observed that the active and break phases in wind significantly impact the overall wind potential output. Although the dry spells are generally found to reduce the overall wind potential, their impact on the potential seems to have declined after the year 2000. The impact of meteorological changes on variations in wind power studied in this work should find applications typically in taking investment decisions on conventional generation facilities, like thermal, which are currently used to maintain the balance of power supply and demand.

  3. Dual regulation of Department of Energy mixed waste

    SciTech Connect

    Dever, G.L.

    1989-01-01

    The purposes of this paper are to discuss the US Department of Energy's (DOE's) experience with dual regulation under the Resource Conservation and Recovery Act (RCRA), as amended, and the Atomic Energy Act (AEA), as amended, of mixed waste and to describe one mechanism for the resolution of inconsistencies that may arise. To date, the department has not identified any unresolvable inconsistency between the AEA and RCRA, although technical differences are being discussed among DOE, EPA, and state regulators at several locations. As long as the flexibilities of RCRA are explored with careful consideration of the radiological hazard of each mixed-waste stream, the potential for inconsistencies between AEA and RCRA that DOE must resolve is expected to remain small.

  4. 78 FR 58533 - FirstEnergy Generation, LLC, Allegheny Energy Supply Company, LLC, and Green Valley Hydro, LLC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project Nos. 2280-017, 2343-084, 2459-245, 2516-057, 2517-036, 3494- 091, 3671-086, 2391-046, 2425-052, and 2509-046] FirstEnergy Generation, LLC, Allegheny Energy...

  5. Technical Study of a Standalone Photovoltaic–Wind Energy Based Hybrid Power Supply Systems for Island Electrification in Malaysia

    PubMed Central

    Samrat, Nahidul Hoque; Ahmad, Norhafizan; Choudhury, Imtiaz Ahmed; Taha, Zahari

    2015-01-01

    Energy is one of the most important factors in the socioeconomic development of a country. In a developing country like Malaysia, the development of islands is mostly related to the availability of electric power. Power generated by renewable energy sources has recently become one of the most promising solutions for the electrification of islands and remote rural areas. But high dependency on weather conditions and the unpredictable nature of these renewable energy sources are the main drawbacks. To overcome this weakness, different green energy sources and power electronic converters need to be integrated with each other. This study presents a battery storage hybrid standalone photovoltaic-wind energy power supply system. In the proposed standalone hybrid system, a DC-DC buck-boost bidirectional converter controller is used to accumulates the surplus hybrid power in the battery bank and supplies this power to the load during the hybrid power shortage by maintaining the constant dc-link voltage. A three-phase voltage source inverter complex vector control scheme is used to control the load side voltage in terms of the voltage amplitude and frequency. Based on the simulation results obtained from MATLAB/Simulink, it has been found that the overall hybrid framework is capable of working under variable weather and load conditions. PMID:26121032

  6. Technical Study of a Standalone Photovoltaic-Wind Energy Based Hybrid Power Supply Systems for Island Electrification in Malaysia.

    PubMed

    Samrat, Nahidul Hoque; Ahmad, Norhafizan; Choudhury, Imtiaz Ahmed; Taha, Zahari

    2015-01-01

    Energy is one of the most important factors in the socioeconomic development of a country. In a developing country like Malaysia, the development of islands is mostly related to the availability of electric power. Power generated by renewable energy sources has recently become one of the most promising solutions for the electrification of islands and remote rural areas. But high dependency on weather conditions and the unpredictable nature of these renewable energy sources are the main drawbacks. To overcome this weakness, different green energy sources and power electronic converters need to be integrated with each other. This study presents a battery storage hybrid standalone photovoltaic-wind energy power supply system. In the proposed standalone hybrid system, a DC-DC buck-boost bidirectional converter controller is used to accumulates the surplus hybrid power in the battery bank and supplies this power to the load during the hybrid power shortage by maintaining the constant dc-link voltage. A three-phase voltage source inverter complex vector control scheme is used to control the load side voltage in terms of the voltage amplitude and frequency. Based on the simulation results obtained from MATLAB/Simulink, it has been found that the overall hybrid framework is capable of working under variable weather and load conditions.

  7. Hypothalamic Wnt Signalling and its Role in Energy Balance Regulation.

    PubMed

    Helfer, G; Tups, A

    2016-03-01

    Wnt signalling and its downstream effectors are well known for their roles in embryogenesis and tumourigenesis, including the regulation of cell proliferation, survival and differentiation. In the nervous system, Wnt signalling has been described mainly during embryonic development, although accumulating evidence suggests that it also plays a major role in adult brain morphogenesis and function. Studies have predominantly concentrated on memory formation in the hippocampus, although recent data indicate that Wnt signalling is also critical for neuroendocrine control of the developed hypothalamus, a brain centre that is key in energy balance regulation and whose dysfunction is implicated in metabolic disorders such as type 2 diabetes and obesity. Based on scattered findings that report the presence of Wnt molecules in the tanycytes and ependymal cells lining the third ventricle and arcuate nucleus neurones of the hypothalamus, their potential importance in key regions of food intake and body weight regulation has been investigated in recent studies. The present review brings together current knowledge on Wnt signalling in the hypothalamus of adult animals and discusses the evidence suggesting a key role for members of the Wnt signalling family in glucose and energy balance regulation in the hypothalamus in diet-induced and genetically obese (leptin deficient) mice. Aspects of Wnt signalling in seasonal (photoperiod sensitive) rodents are also highlighted, given the recent evidence indicating that the Wnt pathway in the hypothalamus is not only regulated by diet and leptin, but also by photoperiod in seasonal animals, which is connected to natural adaptive changes in food intake and body weight. Thus, Wnt signalling appears to be critical as a modulator for normal functioning of the physiological state in the healthy adult brain, and is also crucial for normal glucose and energy homeostasis where its dysregulation can lead to a range of metabolic disorders. © 2016

  8. Chronobiology and obesity: Interactions between circadian rhythms and energy regulation.

    PubMed

    Summa, Keith C; Turek, Fred W

    2014-05-01

    Recent advances in the understanding of the molecular, genetic, neural, and physiologic basis for the generation and organization of circadian clocks in mammals have revealed profound bidirectional interactions between the circadian clock system and pathways critical for the regulation of metabolism and energy balance. The discovery that mice harboring a mutation in the core circadian gene circadian locomotor output cycles kaput (Clock) develop obesity and evidence of the metabolic syndrome represented a seminal moment for the field, clearly establishing a link between circadian rhythms, energy balance, and metabolism at the genetic level. Subsequent studies have characterized in great detail the depth and magnitude of the circadian clock's crucial role in regulating body weight and other metabolic processes. Dietary nutrients have been shown to influence circadian rhythms at both molecular and behavioral levels; and many nuclear hormone receptors, which bind nutrients as well as other circulating ligands, have been observed to exhibit robust circadian rhythms of expression in peripheral metabolic tissues. Furthermore, the daily timing of food intake has itself been shown to affect body weight regulation in mammals, likely through, at least in part, regulation of the temporal expression patterns of metabolic genes. Taken together, these and other related findings have transformed our understanding of the important role of time, on a 24-h scale, in the complex physiologic processes of energy balance and coordinated regulation of metabolism. This research has implications for human metabolic disease and may provide unique and novel insights into the development of new therapeutic strategies to control and combat the epidemic of obesity. © 2014 American Society for Nutrition.

  9. Influence of topiramate in the regulation of energy balance.

    PubMed

    Richard, D; Ferland, J; Lalonde, J; Samson, P; Deshaies, Y

    2000-10-01

    Topiramate (TPM) is a novel neurotherapeutic agent currently indicated for the treatment of epilepsy and undergoing development for other central nervous system indications including neuropathic pain, bipolar disorder, and migraine prophylaxis. TPM is synthesized from D-fructose and contains a sulfamate moiety that is essential for its pharmacologic activity. TPM has been observed to significantly reduce body weight in patients treated for seizure, which has prompted the realization of preclinical studies to characterize the effects of TPM in the regulation of energy balance. Studies carried out in various strains of rats have provided good evidence for the ability of TPM to blunt energy deposition. Body composition analyses from rat trials have demonstrated that TPM inhibits fat deposition while reducing the activity of lipoprotein lipase (LPL) in various white adipose tissue depots. High doses of TPM (likely above the therapeutic dose range) have also been observed to reduce protein gain without catabolic effects. Although TPM cannot be described as a potent anorectic agent, it seems to have the ability to reduce food intake; significant reductions in food intake have been observed in female obese (fa/fa) Zucker rats and in female Wistar rats. TPM can also reduce energy deposition in the absence of alterations in food intake. This effect has been clearly emphasized in female lean (Fa/?) Zucker rats. In female Sprague-Dawley rats, TPM also increased energy expenditure and it has been observed to increase LPL activity in brown adipose tissue, which could indicate that TPM has the ability to enhance regulatory thermogenesis. In addition, TPM stimulates LPL activity in skeletal muscles, further emphasizing its potential to promote substrate oxidation. The mechanisms whereby TPM affects the regulation of energy balance have yet to be understood. TPM represents an antiepileptic drug (AED) with complex biochemical/pharmacologic actions. Its negative effects on energy

  10. Synthesis of Sustainable Energy Supply Chain by the P-Graph Framework

    EPA Science Inventory

    The present work proposes a computer-aided methodology for designing sustainable supply chains in terms of sustainability metrics by utilizing the P-graph framework. The methodology is an outcome of the collaboration between the Office of Research and Development (ORD) of the U.S...

  11. Synthesis of Sustainable Energy Supply Chain by the P-Graph Framework

    EPA Science Inventory

    The present work proposes a computer-aided methodology for designing sustainable supply chains in terms of sustainability metrics by utilizing the P-graph framework. The methodology is an outcome of the collaboration between the Office of Research and Development (ORD) of the U.S...

  12. Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity

    PubMed Central

    Timper, Katharina; Brüning, Jens C.

    2017-01-01

    ABSTRACT The ‘obesity epidemic’ represents a major global socioeconomic burden that urgently calls for a better understanding of the underlying causes of increased weight gain and its associated metabolic comorbidities, such as type 2 diabetes mellitus and cardiovascular diseases. Improving our understanding of the cellular basis of obesity could set the stage for the development of new therapeutic strategies. The CNS plays a pivotal role in the regulation of energy and glucose homeostasis. Distinct neuronal cell populations, particularly within the arcuate nucleus of the hypothalamus, sense the nutrient status of the organism and integrate signals from peripheral hormones including pancreas-derived insulin and adipocyte-derived leptin to regulate calorie intake, glucose metabolism and energy expenditure. The arcuate neurons are tightly connected to other specialized neuronal subpopulations within the hypothalamus, but also to various extrahypothalamic brain regions, allowing a coordinated behavioral response. This At a Glance article gives an overview of the recent knowledge, mainly derived from rodent models, regarding the CNS-dependent regulation of energy and glucose homeostasis, and illustrates how dysregulation of the neuronal networks involved can lead to overnutrition and obesity. The potential impact of recent research findings in the field on therapeutic treatment strategies for human obesity is also discussed. PMID:28592656

  13. Biodiesel Supply and Consumption in the Short-Term Energy Outlook

    EIA Publications

    2009-01-01

    The historical biodiesel consumption data published in the Energy Information Administration's Monthly Energy Review March 2009 edition were revised to account for imports and exports. Table 10.4 of the Monthly Energy Review was expanded to display biodiesel imports, exports, stocks, stock change, and consumption. Similar revisions were made in the April 2009 edition of the Short-Term Energy Outlook (STEO).

  14. Biodiesel Supply and Consumption in the Short-Term Energy Outlook

    EIA Publications

    2009-01-01

    The historical biodiesel consumption data published in the Energy Information Administration's Monthly Energy Review March 2009 edition were revised to account for imports and exports. Table 10.4 of the Monthly Energy Review was expanded to display biodiesel imports, exports, stocks, stock change, and consumption. Similar revisions were made in the April 2009 edition of the Short-Term Energy Outlook (STEO).

  15. Bone and the regulation of global energy balance.

    PubMed

    Zhang, Q; Riddle, R C; Clemens, T L

    2015-06-01

    The skeleton, populated by large numbers of osteoblasts and long-lived osteocytes, requires a constant supply of energy-rich molecules to fuel the synthesis, deposition and mineralization of bone matrix during bone modelling and remodelling. When these energetic demands are not met, bone acquisition is suppressed. Recent findings suggest that key developmental signals emanating from Wnt low-density lipoprotein-related receptor 5 and hypoxia-inducible factor pathways impact osteoblast bioenergetics to accommodate the energy requirements for bone cells to fulfil their function. In vivo studies in several mutant mouse strains have confirmed a link between bone cells and global metabolism, ultimately leading to the identification of hormonal interactions between the skeleton and other tissues. The hormones insulin and leptin affect postnatal bone acquisition, whilst osteocalcin produced by the osteoblast in turn stimulates insulin secretion by the pancreas. These observations have prompted additional questions regarding the nature of the mechanisms of fuel sensing and processing in the osteoblast and their contribution to overall energy utilization and homeostasis. Answers to such questions should advance our understanding of metabolic diseases and may ultimately improve management of affected patients. In this review, we highlight recent studies in this field and offer a perspective on the evolutionary implications of bone as a metabolic endocrine organ. © 2015 The Association for the Publication of the Journal of Internal Medicine.

  16. A method to estimate cow potential and subsequent responses to energy and protein supply according to stage of lactation.

    PubMed

    Daniel, J B; Friggens, N C; Van Laar, H; Ferris, C P; Sauvant, D

    2017-05-01

    Milk responses to dietary change are influenced by the relative production level, that is, the distance between observed production and potential production. The closer the animal is to its potential, the smaller the expected response is to extra nutrients. Therefore, the aim of this work was to provide a method to quantify cow potential, to estimate subsequent responses to changes in nutrient supply. The observed efficiencies in net energy for lactation (NEL) and metabolizable protein (MP) are proposed as a basis to estimate the relative production level of the animal. The rationale for using NEL and MP efficiency (ratios of milk energy yield/NEL above maintenance supply and milk protein yield/MP above maintenance supply) builds on the uniformity of the observed relationships between size of the milk responses and extra NEL supply and MP supply, when centered on a given efficiency. From there, a pivot nutritional situation where MP and NEL efficiency are 0.67 and 1.00, respectively, was defined, from which milk responses could be derived across animals varying in production potential. An implicit assumption of using response equations centered on reference efficiency pivots is that the size of the response to a fixed change in nutrient supply, relative to the pivot, is identical for animals with different production capacities. The proposed approach was evaluated with 2 independent data sets, where different dietary treatments were applied during the whole lactation. In these data sets, MP and NEL above maintenance supply were calculated weekly using the recently updated INRA Systali feed units system. Differences in NEL and MP supply above maintenance between the extreme dietary treatments were large, on average 667 g of MP/d and 13 MJ of NEL/d (3.11 Mcal/d) in the first data set, and 513 g of MP/d and 29 MJ of NEL/d (6.93 Mcal/d) for the second data set. Milk energy yield and milk component yields were predicted with root mean square prediction errors between 7

  17. Energy-efficient and low-voltage design methodology for a supply-sensing CMOS biosensor using biofuel cells for energy-autonomous healthcare applications

    NASA Astrophysics Data System (ADS)

    Kobayashi, Atsuki; Ikeda, Kei; Nakazato, Kazuo; Niitsu, Kiichi

    2017-01-01

    The power sources of wearable sensors play a key role in sensing-system architecture. As potential power sources for sensors monitoring physiological signals near the human body, biofuel cells, which generate energy from the biological environment through chemical methods, have attracted much attention. However, the insufficient open-circuit voltage of biofuel cells owing to thermodynamic limitation is a basic issue. Thus, the use of biofuel cells as a power supply for a sensor imposes a strict limitation upon the power budget. In this report, we propose a design methodology for a low-voltage supply-sensing CMOS biosensor using biofuel cells. To explore the design methodology for performance optimization, a SPICE simulation was conducted. The simulated results reveal an optimum energy-efficient point in the biosensor design parameters. A fabricated 250 nm CMOS test chip was used to verify the validity of the design methodology and the measurement results matched the simulated results.

  18. p75 neurotrophin receptor regulates energy balance in obesity

    PubMed Central

    Baeza-Raja, Bernat; Sachs, Benjamin D.; Li, Pingping; Christian, Frank; Vagena, Eirini; Davalos, Dimitrios; Le Moan, Natacha; Ryu, Jae Kyu; Sikorski, Shoana L.; Chan, Justin P.; Scadeng, Miriam; Taylor, Susan S.; Houslay, Miles D.; Baillie, George S.; Saltiel, Alan R.; Olefsky, Jerrold M.; Akassoglou, Katerina

    2015-01-01

    Summary Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis. Here we show that upon high-fat diet (HFD), the p75 neurotrophin receptor (p75NTR) controls energy expenditure in obese mice. Despite no changes in food intake, p75NTR-null mice were protected from HFD-induced obesity and remained lean due to increased energy expenditure, without developing insulin resistance or liver steatosis. p75NTR directly interacts with the catalytic subunit of protein kinase A (PKA) and regulates cAMP signaling in adipocytes, leading to decreased lipolysis and thermogenesis. Adipocyte-specific depletion of p75NTR or transplantation of p75NTR-null white adipose tissue (WAT) into wild-type mice fed a HFD protected against weight gain and insulin resistance. Our results reveal that signaling from p75NTR to cAMP/PKA regulates energy balance and suggest that non-neuronal functions of neurotrophin receptor signaling could be a new target for treating obesity and the metabolic syndrome. PMID:26748707

  19. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.

    PubMed

    Baeza-Raja, Bernat; Sachs, Benjamin D; Li, Pingping; Christian, Frank; Vagena, Eirini; Davalos, Dimitrios; Le Moan, Natacha; Ryu, Jae Kyu; Sikorski, Shoana L; Chan, Justin P; Scadeng, Miriam; Taylor, Susan S; Houslay, Miles D; Baillie, George S; Saltiel, Alan R; Olefsky, Jerrold M; Akassoglou, Katerina

    2016-01-12

    Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis. Here, we show that the p75 neurotrophin receptor (p75(NTR)) controls energy expenditure in obese mice on a high-fat diet (HFD). Despite no changes in food intake, p75(NTR)-null mice were protected from HFD-induced obesity and remained lean as a result of increased energy expenditure without developing insulin resistance or liver steatosis. p75(NTR) directly interacts with the catalytic subunit of protein kinase A (PKA) and regulates cAMP signaling in adipocytes, leading to decreased lipolysis and thermogenesis. Adipocyte-specific depletion of p75(NTR) or transplantation of p75(NTR)-null white adipose tissue (WAT) into wild-type mice fed a HFD protected against weight gain and insulin resistance. Our results reveal that signaling from p75(NTR) to cAMP/PKA regulates energy balance and suggest that non-CNS neurotrophin receptor signaling could be a target for treating obesity and the metabolic syndrome. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  20. Development of a frequency regulation duty-cycle for standardized energy storage performance testing

    DOE PAGES

    Rosewater, David; Ferreira, Summer

    2016-05-25

    The US DOE Protocol for uniformly measuring and expressing the performance of energy storage systems, first developed in 2012 through inclusive working group activities, provides standardized methodologies for evaluating an energy storage system’s ability to supply specific services to electrical grids. This article elaborates on the data and decisions behind the duty-cycle used for frequency regulation in this protocol. Analysis of a year of publicly available frequency regulation control signal data from a utility was considered in developing the representative signal for this use case. Moreover, this showed that signal standard deviation can be used as a metric for aggressivenessmore » or rigor. From these data, we select representative 2 h long signals that exhibit nearly all of dynamics of actual usage under two distinct regimens, one for average use and the other for highly aggressive use. Our results were combined into a 24-h duty-cycle comprised of average and aggressive segments. The benefits and drawbacks of the selected duty-cycle are discussed along with its potential implications to the energy storage industry.« less

  1. Development of a frequency regulation duty-cycle for standardized energy storage performance testing

    SciTech Connect

    Rosewater, David; Ferreira, Summer

    2016-05-25

    The US DOE Protocol for uniformly measuring and expressing the performance of energy storage systems, first developed in 2012 through inclusive working group activities, provides standardized methodologies for evaluating an energy storage system’s ability to supply specific services to electrical grids. This article elaborates on the data and decisions behind the duty-cycle used for frequency regulation in this protocol. Analysis of a year of publicly available frequency regulation control signal data from a utility was considered in developing the representative signal for this use case. Moreover, this showed that signal standard deviation can be used as a metric for aggressiveness or rigor. From these data, we select representative 2 h long signals that exhibit nearly all of dynamics of actual usage under two distinct regimens, one for average use and the other for highly aggressive use. Our results were combined into a 24-h duty-cycle comprised of average and aggressive segments. The benefits and drawbacks of the selected duty-cycle are discussed along with its potential implications to the energy storage industry.

  2. Development of a frequency regulation duty-cycle for standardized energy storage performance testing

    SciTech Connect

    Rosewater, David; Ferreira, Summer

    2016-05-25

    The US DOE Protocol for uniformly measuring and expressing the performance of energy storage systems, first developed in 2012 through inclusive working group activities, provides standardized methodologies for evaluating an energy storage system’s ability to supply specific services to electrical grids. This article elaborates on the data and decisions behind the duty-cycle used for frequency regulation in this protocol. Analysis of a year of publicly available frequency regulation control signal data from a utility was considered in developing the representative signal for this use case. Moreover, this showed that signal standard deviation can be used as a metric for aggressiveness or rigor. From these data, we select representative 2 h long signals that exhibit nearly all of dynamics of actual usage under two distinct regimens, one for average use and the other for highly aggressive use. Our results were combined into a 24-h duty-cycle comprised of average and aggressive segments. The benefits and drawbacks of the selected duty-cycle are discussed along with its potential implications to the energy storage industry.

  3. Overheated and Out of Breath: Temperature Regulation of Respiration and Oxygen Supply in Coastal Zooplankton

    NASA Astrophysics Data System (ADS)

    Roman, M.; Elliott, D. T.; Pierson, J. J.

    2016-02-01

    Increasing global coastal hypoxia occurs under a large range of temperature and salinity conditions. Temperature directly influences oxygen solubility in seawater as well as the oxygen demand of zooplankton, thus oxygen concentration alone is not sufficient to categorize the biological impact of hypoxia for pelagic organisms. To effectively assess the impacts of hypoxic stress on zooplankton habitat space and production, it is necessary to consider the effects of temperature on both oxygen availability and zooplankton metabolism. Our analysis and modeling evaluate available oxygen (partial pressure and concentration) in the context of ambient temperature conditions and zooplankton oxygen demand. We will present allometric models, accounting for both body size and temperature that predict temperature-dependent oxygen supply and demand in coastal zooplankton. Our goal is to develop generalized, functional relationships that describe and quantify the interactive effects of temperature and low oxygen on coastal zooplankton that can lead to improved size-structured models that serve to predict impacts of increasing coastal hypoxia on pelagic food webs.

  4. Regulation of systemic energy homeostasis by serotonin in adipose tissues

    PubMed Central

    Oh, Chang-Myung; Namkung, Jun; Go, Younghoon; Shong, Ko Eun; Kim, Kyuho; Kim, Hyeongseok; Park, Bo-Yoon; Lee, Ho Won; Jeon, Yong Hyun; Song, Junghan; Shong, Minho; Yadav, Vijay K.; Karsenty, Gerard; Kajimura, Shingo; Lee, In-Kyu; Park, Sangkyu; Kim, Hail

    2015-01-01

    Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis. Here we show 5-HT regulates white and brown adipose tissue function. Pharmacological inhibition of 5-HT synthesis leads to inhibition of lipogenesis in epididymal white adipose tissue (WAT), induction of browning in inguinal WAT and activation of adaptive thermogenesis in brown adipose tissue (BAT). Mice with inducible Tph1 KO in adipose tissues exhibit a similar phenotype as mice in which 5-HT synthesis is inhibited pharmacologically, suggesting 5-HT has localized effects on adipose tissues. In addition, Htr3a KO mice exhibit increased energy expenditure and reduced weight gain when fed a high-fat diet. Treatment with an Htr2a antagonist reduces lipid accumulation in 3T3-L1 adipocytes. These data suggest important roles for adipocyte-derived 5-HT in controlling energy homeostasis. PMID:25864946

  5. Regulation of systemic energy homeostasis by serotonin in adipose tissues.

    PubMed

    Oh, Chang-Myung; Namkung, Jun; Go, Younghoon; Shong, Ko Eun; Kim, Kyuho; Kim, Hyeongseok; Park, Bo-Yoon; Lee, Ho Won; Jeon, Yong Hyun; Song, Junghan; Shong, Minho; Yadav, Vijay K; Karsenty, Gerard; Kajimura, Shingo; Lee, In-Kyu; Park, Sangkyu; Kim, Hail

    2015-04-13

    Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis. Here we show 5-HT regulates white and brown adipose tissue function. Pharmacological inhibition of 5-HT synthesis leads to inhibition of lipogenesis in epididymal white adipose tissue (WAT), induction of browning in inguinal WAT and activation of adaptive thermogenesis in brown adipose tissue (BAT). Mice with inducible Tph1 KO in adipose tissues exhibit a similar phenotype as mice in which 5-HT synthesis is inhibited pharmacologically, suggesting 5-HT has localized effects on adipose tissues. In addition, Htr3a KO mice exhibit increased energy expenditure and reduced weight gain when fed a high-fat diet. Treatment with an Htr2a antagonist reduces lipid accumulation in 3T3-L1 adipocytes. These data suggest important roles for adipocyte-derived 5-HT in controlling energy homeostasis.

  6. Hypothalamic Lipids: Key Regulators of Whole Body Energy Balance.

    PubMed

    González-García, Ismael; Fernø, Johan; Diéguez, Carlos; Nogueiras, Rubén; López, Miguel

    2017-01-01

    Hypothalamic lipid metabolism plays a major role in the physiological regulation of energy balance. Modulation of several enzymatic activities that control lipid biosynthesis, such as fatty acid synthase and AMP-activated protein kinase, impacts both feeding and energy expenditure. However, lipids can also cause pathological alterations in the hypothalamus. Lipotoxicity is promoted by excess lipids in tissues not suitable for their storage. A large amount of evidence has demonstrated that lipotoxicity is a pathophysiological mechanism leading to metabolic diseases such as insulin resistance, cardiomyopathy, atherosclerosis, and steatohepatitis. Current data have reported that, similar to what is observed in peripheral tissues, complex lipids such as ceramides and sphingolipids act as lipotoxic species at the hypothalamic level to impact metabolism. Here, we will review what is currently known about hypothalamic lipid metabolism and the modulation of energy homeostasis. © 2016 S. Karger AG, Basel.

  7. Daily magnesium fluxes regulate cellular timekeeping and energy balance.

    PubMed

    Feeney, Kevin A; Hansen, Louise L; Putker, Marrit; Olivares-Yañez, Consuelo; Day, Jason; Eades, Lorna J; Larrondo, Luis F; Hoyle, Nathaniel P; O'Neill, John S; van Ooijen, Gerben

    2016-04-21

    Circadian clocks are fundamental to the biology of most eukaryotes, coordinating behaviour and physiology to resonate with the environmental cycle of day and night through complex networks of clock-controlled genes. A fundamental knowledge gap exists, however, between circadian gene expression cycles and the biochemical mechanisms that ultimately facilitate circadian regulation of cell biology. Here we report circadian rhythms in the intracellular concentration of magnesium ions, [Mg(2+)]i, which act as a cell-autonomous timekeeping component to determine key clock properties both in a human cell line and in a unicellular alga that diverged from each other more than 1 billion years ago. Given the essential role of Mg(2+) as a cofactor for ATP, a functional consequence of [Mg(2+)]i oscillations is dynamic regulation of cellular energy expenditure over the daily cycle. Mechanistically, we find that these rhythms provide bilateral feedback linking rhythmic metabolism to clock-controlled gene expression. The global regulation of nucleotide triphosphate turnover by intracellular Mg(2+) availability has potential to impact upon many of the cell's more than 600 MgATP-dependent enzymes and every cellular system where MgNTP hydrolysis becomes rate limiting. Indeed, we find that circadian control of translation by mTOR is regulated through [Mg(2+)]i oscillations. It will now be important to identify which additional biological processes are subject to this form of regulation in tissues of multicellular organisms such as plants and humans, in the context of health and disease.

  8. Developmental programming of energy balance and its hypothalamic regulation.

    PubMed

    Remmers, Floor; Delemarre-van de Waal, Henriette A

    2011-04-01

    Developmental programming is an important physiological process that allows different phenotypes to originate from a single genotype. Through plasticity in early life, the developing organism can adopt a phenotype (within the limits of its genetic background) that is best suited to its expected environment. In humans, together with the relative irreversibility of the phenomenon, the low predictive value of the fetal environment for later conditions in affluent countries makes it a potential contributor to the obesity epidemic of recent decades. Here, we review the current evidence for developmental programming of energy balance. For a proper understanding of the subject, knowledge about energy balance is indispensable. Therefore, we first present an overview of the major hypothalamic routes through which energy balance is regulated and their ontogeny. With this background, we then turn to the available evidence for programming of energy balance by the early nutritional environment, in both man and rodent models. A wealth of studies suggest that energy balance can indeed be permanently affected by the early-life environment. However, the direction of the effects of programming appears to vary considerably, both between and within different animal models. Because of these inconsistencies, a comprehensive picture is still elusive. More standardization between studies seems essential to reach veritable conclusions about the role of developmental programming in adult energy balance and obesity.

  9. Compensatory Changes in Energy Balance Regulation over One Athletic Season.

    PubMed

    Silva, Analiza M; Matias, Catarina N; Santos, Diana A; Thomas, Diana; Bosy-Westphal, Anja; MüLLER, Manfred J; Heymsfield, Steven B; Sardinha, LUíS B

    2017-06-01

    Mechanisms in energy balance (EB) regulation may include compensatory changes in energy intake (EI) and metabolic adaption (MA), but information is unavailable in athletes who often change EB components. We aim to investigate EB regulation compensatory mechanisms over one athletic season. Fifty-seven athletes (39 males/18 females; handball, volleyball, basketball, triathlon, and swimming) were evaluated from the beginning to the competitive phase of the season. Resting and total energy expenditure (REE and TEE, respectively) were assessed by indirect calorimetry and doubly labeled water, respectively, and physical activity energy expenditure was determined as TEE - 0.1(TEE) - REE. Fat mass (FM) and fat-free mass (FFM) were evaluated by dual-energy x-ray absorptiometry and changed body energy stores was determined by 1.0(ΔFFM/Δtime) + 9.5(ΔFM/Δtime). EI was derived as TEE + EB. REE was predicted from baseline FFM, FM, sex, and sports. %MA was calculated as 100(measured REE/predicted REE-1) and MA (kcal) as %MA/100 multiplied by baseline measured REE. Average EI minus average physical activity energy expenditure was computed as a proxy of average energy availability, assuming that a constant nonexercise EE occurred over the season. Body mass increased by 0.8 ± 2.5 kg (P < 0.05), but a large individual variability was found ranging from -6.1 to 5.2 kg. The TEE raise (16.8% ± 11.7%) was compensated by an increase EI change (16.3% ± 12.0%) for the whole group (P < 0.05). MA was found in triathletes, sparing 128 ± 168 kcal·d, and basketball players, dissipating 168 ± 205 kcal·d (P < 0.05). MA was associated (P < 0.05) with EB and energy availability (r = 0.356 and r = 0.0644, respectively). TEE increased over the season without relevant mean changes in weight, suggesting that EI compensation likely occurred. The thrifty or spendthrift phenotypes observed among sports and the demanding workloads these athletes are exposed to highlight the need for sport

  10. Impact of energy prices and cellulosic biomass supply on agriculture, energy, and the environment: An integrated modeling approach

    EPA Science Inventory

    The accelerated growth in biofuels markets has both created and reinforced linkages between agricultural and energy markets. This study investigates the dynamics in agricultural and biofuel markets under alternative price scenarios for both crude oil and natural gas. Two energy ...

  11. Impact of energy prices and cellulosic biomass supply on agriculture, energy, and the environment: An integrated modeling approach

    EPA Science Inventory

    The accelerated growth in biofuels markets has both created and reinforced linkages between agricultural and energy markets. This study investigates the dynamics in agricultural and biofuel markets under alternative price scenarios for both crude oil and natural gas. Two energy ...

  12. Neutralization of space charge on high-current low-energy ion beam by low-energy electrons supplied from silicon based field emitter arrays

    SciTech Connect

    Gotoh, Yasuhito; Tsuji, Hiroshi; Taguchi, Shuhei; Ikeda, Keita; Kitagawa, Takayuki; Ishikawa, Junzo; Sakai, Shigeki

    2012-11-06

    Neutralization of space charge on a high-current and low-energy ion beam was attempted to reduce the divergence with an aid of low-energy electrons supplied from silicon based field emitter arrays (Si-FEAs). An argon ion beam with the energy of 500 eV and the current of 0.25 mA was produced by a microwave ion source. The initial beam divergence and the emittance were measured at the entrance of the analysis chamber in order to estimate the intrinsic factors for beam divergence. The current density distribution of the beam after transport of 730 mm was measured by a movable Faraday cup, with and without electron supply from Si-FEAs. A similar experiment was performed with tungsten filaments as an electron source. The results indicated that the electron supply from FEA had almost the same effect as the thermionic filament, and it was confirmed that both electron sources can neutralize the ion beam.

  13. Overview of human obesity and central mechanisms regulating energy homeostasis.

    PubMed

    Crowley, Vivion E F

    2008-05-01

    Obesity is now regarded as a global epidemic affecting both adults and children, and is associated with significant morbidity and mortality. Thus the effective management of obesity has become an important clinical focus. Therefore, an understanding of the pathways controlling appetite, satiety and food intake is critical for gaining an insight into the pathogenesis of obesity and also for the development of diagnostic tests and therapeutic agents for use in the clinical management of this condition. Over the last decade or more research using both mouse and human genetic models has elucidated the critical role of the leptin-melanocortin pathway in the hypothalamus, in regulating mammalian energy balance. In tandem with this, a clearer understanding of the regulation of gut-derived hormones and their interaction with the central nervous system has further illuminated the complex interplay between central and peripheral aspects of energy regulation. The obesity epidemic and the expanded knowledge base relating to its aetiopathogenesis have specific implications for clinical biochemistry. In particular, an increase in workload may be expected due to biochemical investigation of obesity and its co-morbidities. Moreover, advice on the in-depth investigation of complex cases of obesity may be sought, including information on newer diagnostic tests, such as serum leptin or molecular genetic analysis. There may also be a substantive role for chemical pathologists in establishing and running clinical obesity services. Finally, clinical biochemistry has a role in research pertaining to obesity and cardiometabolic risk.

  14. Hypoxia inducible factor-2α regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors.

    PubMed

    Duan, Li-Juan; Takeda, Kotaro; Fong, Guo-Hua

    2014-01-01

    Here we investigate the role of hypoxia inducible factor (HIF)-2α in coordinating the development of retinal astrocytic and vascular networks. Three Cre mouse lines were used to disrupt floxed Hif-2α, including Rosa26(CreERT2), Tie2(Cre), and GFAP(Cre). Global Hif-2α disruption by Rosa26(CreERT2) led to reduced astrocytic and vascular development in neonatal retinas, whereas endothelial disruption by Tie2(Cre) had no apparent effects. Hif-2α deletion in astrocyte progenitors by GFAP(Cre) significantly interfered with the development of astrocytic networks, which failed to reach the retinal periphery and were incapable of supporting vascular development. Perplexingly, the abundance of strongly GFAP(+) mature astrocytes transiently increased at P0 before they began to lag behind the normal controls by P3. Pax2(+) and PDGFRα(+) astrocytic progenitors and immature astrocytes were dramatically diminished at all stages examined. Despite decreased number of astrocyte progenitors, their proliferation index or apoptosis was not altered. The above data can be reconciled by proposing that HIF-2α is required for maintaining the supply of astrocyte progenitors by slowing down their differentiation into non-proliferative mature astrocytes. HIF-2α deficiency in astrocyte progenitors may accelerate their differentiation into astrocytes, a change which greatly interferes with the replenishment of astrocyte progenitors due to insufficient time for proliferation. Rapidly declining progenitor supply may lead to premature cessation of astrocyte development. Given that HIF-2α protein undergoes oxygen dependent degradation, an interesting possibility is that retinal blood vessels may regulate astrocyte differentiation through their oxygen delivery function. While our findings support the consensus that retinal astrocytic template guides vascular development, they also raise the possibility that astrocytic and vascular networks may mutually regulate each other's development

  15. Involvement of the TetR-Type Regulator PaaR in the Regulation of Pristinamycin I Biosynthesis through an Effect on Precursor Supply in Streptomyces pristinaespiralis

    PubMed Central

    Zhao, Yawei; Feng, Rongrong; Zheng, Guosong; Tian, Jinzhong; Ruan, Lijun; Ge, Mei; Jiang, Weihong

    2015-01-01

    transcription of paa genes involved in phenylacetic acid (PAA) catabolism, was identified as playing a positive role in the regulation of pristinamycin I (PI) by affecting the supply of one of seven amino acid precursors, l-phenylglycine, in Streptomyces pristinaespiralis. To our knowledge, this is the first report describing the interplay between PAA catabolism and antibiotic biosynthesis in Streptomyces strains. Considering that the PAA catabolic pathway and its regulation by PaaR are widespread in antibiotic-producing actinomycetes, it could be suggested that PaaR-dependent regulation of antibiotic biosynthesis might commonly exist. PMID:25868645

  16. Manpower requirements and supply for magnetic-fusion energy, 1981-2000

    SciTech Connect

    Finn, M.G.; Hansen, A.H.; Harr, P.A.

    1981-09-01

    This study has been conducted to help the US Department of Energy (DOE) complete a task assigned to it by the Magnetic Fusion Energy Engineering Act of 1980 (P.L. 96-386). The law requires that the Secretary make recommendations regarding the need for increased support for education in engineering and scientific disciplines. This study focuses on estimating current employment and future manpower requirements for magnetic fusion energy to the year 2000. It also examines sources of labor for fusion energy and competing demands for the disciplines most important to the future growth of fusion energy.

  17. An overview of US energy options: Supply- and demand-side history and prospects

    NASA Technical Reports Server (NTRS)

    Hirshberg, A. S.

    1977-01-01

    An overview was provided of nonsolar energy policy options available to the United States until solar energy conversion and utilization devices can produce power at a cost competitive with that obtained from fossil fuels. The economics of the development of new fossil fuel sources and of mandatory conservation measures in energy usage were clarified in the context of the historic annual rate of increase in U.S. energy demand. An attempt was made to compare the costs and relative efficiencies of energy obtainable from various sources by correlating the many confusing measurement units in current use.

  18. Cigarette smoking and brain regulation of energy homeostasis.

    PubMed

    Chen, Hui; Saad, Sonia; Sandow, Shaun L; Bertrand, Paul P

    2012-01-01

    Cigarette smoking is an addictive behavior, and is the primary cause of cardiovascular and pulmonary disease, and cancer (among other diseases). Cigarette smoke contains thousands of components that may affect caloric intake and energy expenditure, although nicotine is the major addictive substance present, and has the best described actions. Nicotine exposure from cigarette smoke can change brain feeding regulation to reduce appetite via both energy homeostatic and reward mechanisms, causing a negative energy state which is characterized by reduced energy intake and increased energy expenditure that are linked to low body weight. These findings have led to the public perception that smoking is associated with weight loss. However, its effects at reducing abdominal fat mass (a predisposing factor for glucose intolerance and insulin resistance) are marginal, and its promotion of lean body mass loss in animal studies suggests a limited potential for treatment in obesity. Smoking during pregnancy puts pressure on the mother's metabolic system and is a significant contributor to adverse pregnancy outcomes. Smoking is a predictor of future risk for respiratory dysfunction, social behavioral problems, cardiovascular disease, obesity, and type-2 diabetes. Catch-up growth is normally observed in children exposed to intrauterine smoke, which has been linked to subsequent childhood obesity. Nicotine can have a profound impact on the developing fetal brain, via its ability to rapidly and fully pass the placenta. In animal studies this has been linked with abnormal hypothalamic gene expression of appetite regulators such as downregulation of NPY and POMC in the arcuate nucleus of the hypothalamus. Maternal smoking or nicotine replacement leads to unhealthy eating habits (such as junk food addiction) and other behavioral disorders in the offspring.

  19. Cigarette Smoking and Brain Regulation of Energy Homeostasis

    PubMed Central

    Chen, Hui; Saad, Sonia; Sandow, Shaun L.; Bertrand, Paul P.

    2012-01-01

    Cigarette smoking is an addictive behavior, and is the primary cause of cardiovascular and pulmonary disease, and cancer (among other diseases). Cigarette smoke contains thousands of components that may affect caloric intake and energy expenditure, although nicotine is the major addictive substance present, and has the best described actions. Nicotine exposure from cigarette smoke can change brain feeding regulation to reduce appetite via both energy homeostatic and reward mechanisms, causing a negative energy state which is characterized by reduced energy intake and increased energy expenditure that are linked to low body weight. These findings have led to the public perception that smoking is associated with weight loss. However, its effects at reducing abdominal fat mass (a predisposing factor for glucose intolerance and insulin resistance) are marginal, and its promotion of lean body mass loss in animal studies suggests a limited potential for treatment in obesity. Smoking during pregnancy puts pressure on the mother’s metabolic system and is a significant contributor to adverse pregnancy outcomes. Smoking is a predictor of future risk for respiratory dysfunction, social behavioral problems, cardiovascular disease, obesity, and type-2 diabetes. Catch-up growth is normally observed in children exposed to intrauterine smoke, which has been linked to subsequent childhood obesity. Nicotine can have a profound impact on the developing fetal brain, via its ability to rapidly and fully pass the placenta. In animal studies this has been linked with abnormal hypothalamic gene expression of appetite regulators such as downregulation of NPY and POMC in the arcuate nucleus of the hypothalamus. Maternal smoking or nicotine replacement leads to unhealthy eating habits (such as junk food addiction) and other behavioral disorders in the offspring. PMID:22848202

  20. Hypothalamic CB1 cannabinoid receptors regulate energy balance in mice.

    PubMed

    Cardinal, Pierre; Bellocchio, Luigi; Clark, Samantha; Cannich, Astrid; Klugmann, Matthias; Lutz, Beat; Marsicano, Giovanni; Cota, Daniela

    2012-09-01

    Cannabinoid type 1 (CB(1)) receptor activation is generally considered a powerful orexigenic signal and inhibition of the endocannabinoid system is beneficial for the treatment of obesity and related metabolic diseases. The hypothalamus plays a critical role in regulating energy balance by modulating both food intake and energy expenditure. Although CB(1) receptor signaling has been implicated in the modulation of both these mechanisms, a complete understanding of its role in the hypothalamus is still lacking. Here we combined a genetic approach with the use of adeno-associated viral vectors to delete the CB(1) receptor gene in the adult mouse hypothalamus and assessed the impact of such manipulation on the regulation of energy balance. Viral-mediated deletion of the CB(1) receptor gene in the hypothalamus led to the generation of Hyp-CB(1)-KO mice, which displayed an approximately 60% decrease in hypothalamic CB(1) receptor mRNA levels. Hyp-CB(1)-KO mice maintained on a normocaloric, standard diet showed decreased body weight gain over time, which was associated with increased energy expenditure and elevated β(3)-adrenergic receptor and uncoupling protein-1 mRNA levels in the brown adipose tissue but, surprisingly, not to changes in food intake. Additionally, Hyp-CB(1)-KO mice were insensitive to the anorectic action of the hormone leptin (5 mg/kg) and displayed a time-dependent hypophagic response to the CB(1) inverse agonist rimonabant (3 mg/kg). Altogether these findings suggest that hypothalamic CB(1) receptor signaling is a key determinant of energy expenditure under basal conditions and reveal its specific role in conveying the effects of leptin and pharmacological CB1 receptor antagonism on food intake.

  1. Energy Density, Energy Intake, and Body Weight Regulation in Adults12345

    PubMed Central

    Karl, J. Philip; Roberts, Susan B.

    2014-01-01

    The role of dietary energy density (ED) in the regulation of energy intake (EI) is controversial. Methodologically, there is also debate about whether beverages should be included in dietary ED calculations. To address these issues, studies examining the effects of ED on EI or body weight in nonelderly adults were reviewed. Different approaches to calculating dietary ED do not appear to alter the direction of reported relations between ED and body weight. Evidence that lowering dietary ED reduces EI in short-term studies is convincing, but there are currently insufficient data to determine long-term effectiveness for weight loss. The review also identified key barriers to progress in understanding the role of ED in energy regulation, in particular the absence of a standard definition of ED, and the lack of data from multiple long-term clinical trials examining the effectiveness of low-ED diet recommendations for preventing both primary weight gain and weight regain in nonobese individuals. Long-term clinical trials designed to examine the impact of dietary ED on energy regulation, and including multiple ED calculation methods within the same study, are still needed to determine the importance of ED in the regulation of EI and body weight. PMID:25398750

  2. Biogeomorphic responses to flow regulation and fine sediment supply in Mediterranean streams (the Guadalete River, southern Spain)

    NASA Astrophysics Data System (ADS)

    González del Tánago, M.; Bejarano, M. D.; García de Jalón, D.; Schmidt, J. C.

    2015-09-01

    Geomorphic responses to damming are primarily determined by the magnitude of sediment transport and sediment supply alteration and by the resulting change in the balance between the two. The former change is caused by alterations in the flow regime that are caused by reservoir operations. Flow regime changes also affect the distribution and amount of riparian vegetation that, in turn, also may enhance geomorphic responses. The latter change is caused by sediment trapping in reservoirs and by the magnitude of sediment supply from watersheds that are downstream from the dam. We examined the bio-geomorphic responses to flow regulation along a Mediterranean stream located in an agricultural area of southern Spain where there is significant fine sediment erosion from adjacent hillsides. We measured changes in active channel width and riparian corridor features during the last fifty years, based on field work and aerial photographs surveys from 1956, 1984 and 2004. We assessed the hydrological alteration and sediment delivery trends linked to dam operation and land use changes. Channel narrowing of nearly 75% and 30% reduction in total corridor area, together with average accretion rates of 0.045 m y-1 and vegetation encroachment with a 305% increase of mature forest occurred between 1956 and 2004. Causal linkages were attributed to the strong reduction of peak flows and transport capacity of flows, together with land-use changes that likely promoted increased fine sediment delivery. Vegetation overgrowth favored by increased summer flows could contribute to the narrowing and aggradation processes. Our results differ from channel responses to damming in Mediterranean regions dominated by steep gradient gravel bed rivers, and highlight the relevance of topography and land-use affecting the sediment regime downstream from the dams. We argue for a more holistic approach of water resources and land-use management at the catchment scale in order to understand the synergistic

  3. Supply and demand in energy and agriculture: Emitters of CO{sub 2} and possibilities for global biomass energy strategies

    SciTech Connect

    Ahamer, G.; Hubergasse, J.

    1996-12-31

    As seen from the perspective of global E3-modelling (= environment-economy-energy), the sectors of energy and of agriculture are double players situated in a field of tension: both exhibit growing emissions--but both also exhibit reduction potentials for CO{sub 2}, if areas are used for growth of biomass energy carriers. On the one hand, meeting food demand requires increasing agricultural land use in some regions, on the other hand in other regions, an important input of fossil fuels buys higher efficiency levels. In the First World, newly set-aside land can be used for biomass energy production. Before envisaging global strategies for CO{sub 2} emission reductions and more specifically for an enhanced use of biomass for energy, the present boundary conditions of the global energy and agricultural systems have to be analyzed. In a second step, a likely future development has to be contrasted with the desirable increase of bioenergy.

  4. Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis

    PubMed Central

    Shen, Minqian; Shi, Haifei

    2015-01-01

    The liver is one of the most essential organs involved in the regulation of energy homeostasis. Hepatic steatosis, a major manifestation of metabolic syndrome, is associated with imbalance between lipid formation and breakdown, glucose production and catabolism, and cholesterol synthesis and secretion. Epidemiological studies show sex difference in the prevalence in fatty liver disease and suggest that sex hormones may play vital roles in regulating hepatic steatosis. In this review, we summarize current literature and discuss the role of estrogens and androgens and the mechanisms through which estrogen receptors and androgen receptors regulate lipid and glucose metabolism in the liver. In females, estradiol regulates liver metabolism via estrogen receptors by decreasing lipogenesis, gluconeogenesis, and fatty acid uptake, while enhancing lipolysis, cholesterol secretion, and glucose catabolism. In males, testosterone works via androgen receptors to increase insulin receptor expression and glycogen synthesis, decrease glucose uptake and lipogenesis, and promote cholesterol storage in the liver. These recent integrated concepts suggest that sex hormone receptors could be potential promising targets for the prevention of hepatic steatosis. PMID:26491440

  5. Donepezil regulates energy metabolism and favors bone mass accrual.

    PubMed

    Eimar, Hazem; Alebrahim, Sharifa; Manickam, Garthiga; Al-Subaie, Ahmed; Abu-Nada, Lina; Murshed, Monzur; Tamimi, Faleh

    2016-03-01

    The autonomous nervous system regulates bone mass through the sympathetic and parasympathetic arms. The sympathetic nervous system (SNS) favors bone loss whereas the parasympathetic nervous system (PNS) promotes bone mass accrual. Donepezil, a central-acting cholinergic agonist, has been shown to down-regulate SNS and up-regulate PNS signaling tones. Accordingly, we hypothesize that the use of donepezil could have beneficial effects in regulating bone mass. To test our hypothesis, two groups of healthy female mice were treated either with donepezil or saline. Differences in body metabolism and bone mass of the treated groups were compared. Body and visceral fat weights as well as serum leptin level were increased in donepezil-treated mice compared to control, suggesting that donepezil effects on SNS influenced metabolic activity. Donepezil-treated mice had better bone quality than controls due to a decrease in osteoclasts number. These results indicate that donepezil is able to affect whole body energy metabolism and favors bone mass in young female WT mice.

  6. CART in the regulation of appetite and energy homeostasis

    PubMed Central

    Lau, Jackie; Herzog, Herbert

    2014-01-01

    The cocaine- and amphetamine-regulated transcript (CART) has been the subject of significant interest for over a decade. Work to decipher the detailed mechanism of CART function has been hampered by the lack of specific pharmacological tools like antagonists and the absence of a specific CART receptor(s). However, extensive research has been devoted to elucidate the role of the CART peptide and it is now evident that CART is a key neurotransmitter and hormone involved in the regulation of diverse biological processes, including food intake, maintenance of body weight, reward and addiction, stress response, psychostimulant effects and endocrine functions (Rogge et al., 2008; Subhedar et al., 2014). In this review, we focus on knowledge gained on CART's role in controlling appetite and energy homeostasis, and also address certain species differences between rodents and humans. PMID:25352770

  7. CART in the regulation of appetite and energy homeostasis.

    PubMed

    Lau, Jackie; Herzog, Herbert

    2014-01-01

    The cocaine- and amphetamine-regulated transcript (CART) has been the subject of significant interest for over a decade. Work to decipher the detailed mechanism of CART function has been hampered by the lack of specific pharmacological tools like antagonists and the absence of a specific CART receptor(s). However, extensive research has been devoted to elucidate the role of the CART peptide and it is now evident that CART is a key neurotransmitter and hormone involved in the regulation of diverse biological processes, including food intake, maintenance of body weight, reward and addiction, stress response, psychostimulant effects and endocrine functions (Rogge et al., 2008; Subhedar et al., 2014). In this review, we focus on knowledge gained on CART's role in controlling appetite and energy homeostasis, and also address certain species differences between rodents and humans.

  8. Delineating the regulation of energy homeostasis using hypothalamic cell models.

    PubMed

    Wellhauser, Leigh; Gojska, Nicole M; Belsham, Denise D

    2015-01-01

    Attesting to its intimate peripheral connections, hypothalamic neurons integrate nutritional and hormonal cues to effectively manage energy homeostasis according to the overall status of the system. Extensive progress in the identification of essential transcriptional and post-translational mechanisms regulating the controlled expression and actions of hypothalamic neuropeptides has been identified through the use of animal and cell models. This review will introduce the basic techniques of hypothalamic investigation both in vivo and in vitro and will briefly highlight the key advantages and challenges of their use. Further emphasis will be place on the use of immortalized models of hypothalamic neurons for in vitro study of feeding regulation, with a particular focus on cell lines proving themselves most fruitful in deciphering fundamental basics of NPY/AgRP, Proglucagon, and POMC neuropeptide function. Copyright © 2014 Elsevier Inc. All rights reserved.

  9. the Ĝ infrared search for extraterrestrial civilizations with large energy supplies. II. Framework, strategy, and first result

    SciTech Connect

    Wright, J. T.; Griffith, R. L.; Sigurdsson, S.; Povich, M. S.; Mullan, B.

    2014-09-01

    We describe the framework and strategy of the Ĝ infrared search for extraterrestrial civilizations with large energy supplies, which will use the wide-field infrared surveys of WISE and Spitzer to search for these civilizations' waste heat. We develop a formalism for translating mid-infrared photometry into quantitative upper limits on extraterrestrial energy supplies. We discuss the likely sources of false positives, how dust can and will contaminate our search, and prospects for distinguishing dust from alien waste heat. We argue that galaxy-spanning civilizations may be easier to distinguish from natural sources than circumstellar civilizations (i.e., Dyson spheres), although GAIA will significantly improve our capability to identify the latter. We present a zeroth order null result of our search based on the WISE all-sky catalog: we show, for the first time, that Kardashev Type III civilizations (as Kardashev originally defined them) are very rare in the local universe. More sophisticated searches can extend our methodology to smaller waste heat luminosities, and potentially entirely rule out (or detect) both Kardashev Type III civilizations and new physics that allows for unlimited 'free' energy generation.

  10. The Ĝ Infrared Search for Extraterrestrial Civilizations with Large Energy Supplies. II. Framework, Strategy, and First Result

    NASA Astrophysics Data System (ADS)

    Wright, J. T.; Griffith, R. L.; Sigurdsson, S.; Povich, M. S.; Mullan, B.

    2014-09-01

    We describe the framework and strategy of the Ĝ infrared search for extraterrestrial civilizations with large energy supplies, which will use the wide-field infrared surveys of WISE and Spitzer to search for these civilizations' waste heat. We develop a formalism for translating mid-infrared photometry into quantitative upper limits on extraterrestrial energy supplies. We discuss the likely sources of false positives, how dust can and will contaminate our search, and prospects for distinguishing dust from alien waste heat. We argue that galaxy-spanning civilizations may be easier to distinguish from natural sources than circumstellar civilizations (i.e., Dyson spheres), although GAIA will significantly improve our capability to identify the latter. We present a zeroth order null result of our search based on the WISE all-sky catalog: we show, for the first time, that Kardashev Type III civilizations (as Kardashev originally defined them) are very rare in the local universe. More sophisticated searches can extend our methodology to smaller waste heat luminosities, and potentially entirely rule out (or detect) both Kardashev Type III civilizations and new physics that allows for unlimited "free" energy generation.

  11. Quality evaluation of energy consumed in flow regulation method by speed variation in centrifugal pumps

    NASA Astrophysics Data System (ADS)

    Morales, S.; Culman, M.; Acevedo, C.; Rey, C.

    2014-06-01

    Nowadays, energy efficiency and the Electric Power Quality are two inseparable issues in the evaluation of three-phase induction motors, framed within the program of Rational and Efficient Use of Energy (RUE).The use of efficient energy saving devices has been increasing significantly in RUE programs, for example the use of variable frequency drives (VFD) in pumping systems.The overall objective of the project was to evaluate the impact on power quality and energy efficiency in a centrifugal pump driven by an induction three-phase motor, using the flow control method of speed variation by VFD. The fundamental purpose was to test the opinions continuously heard about the use of flow control methods in centrifugal pumps, analyzing the advantages and disadvantages that have been formulated deliberately in order to offer support to the industry in taking correct decisions. The VFD changes the speed of the motor-pump system increasing efficiency compared to the classical methods of regulation. However, the VFD originates conditions that degrade the quality of the electric power supplied to the system and therefore its efficiency, due to the nonlinearity and presence of harmonic currents. It was possible to analyze the power quality, ensuring that the information that comes to the industry is generally biased.

  12. The Role of the Latvian District Heating System in the Development of Sustainable Energy Supply

    NASA Astrophysics Data System (ADS)

    Bazbauers, Gatis; Cimdina, Ginta

    2011-01-01

    The aim of the study is to determine whether and to what extent it is possible to use excess electricity produced by wind power plants during low demand periods for district heat production by heat pumps. Energy system analysis on an hourly basis is conducted at various capacities of wind power plants. The results show that it is possible to increase the share of renewable energy sources, decrease the use of primary energy sources and CO2 emissions per unit of the produced energy, i.e. heat and electricity, by using the surplus electricity produced by wind power in the heat pumps combined with the heat storage.

  13. DC Bus Regulation with a Flywheel Energy Storage System

    NASA Technical Reports Server (NTRS)

    Kenny, Barbara H.; Kascak, Peter E.

    2003-01-01

    This paper describes the DC bus regulation control algorithm for the NASA flywheel energy storage system during charge, charge reduction and discharge modes of operation. The algorithm was experimentally verified with results given in a previous paper. This paper presents the necessary models for simulation with detailed block diagrams of the controller algorithm. It is shown that the flywheel system and the controller can be modeled in three levels of detail depending on the type of analysis required. The three models are explained and then compared using simulation results.

  14. Adipocytes as regulators of energy balance and glucose homeostasis

    PubMed Central

    Rosen, Evan D.; Spiegelman, Bruce M.

    2011-01-01

    Adipocytes have been studied with increasing intensity as a result of the emergence of obesity as a serious public health problem and the realization that adipose tissue serves as an integrator of various physiological pathways. In particular, their role in calorie storage makes adipocytes well suited to the regulation of energy balance. Adipose tissue also serves as a crucial integrator of glucose homeostasis. Knowledge of adipocyte biology is therefore crucial for understanding the pathophysiological basis of obesity and metabolic diseases such as type 2 diabetes. Furthermore, the rational manipulation of adipose physiology is a promising avenue for therapy of these conditions. PMID:17167472

  15. Energy balance regulation by endocannabinoids at central and peripheral levels.

    PubMed

    Quarta, Carmelo; Mazza, Roberta; Obici, Silvana; Pasquali, Renato; Pagotto, Uberto

    2011-09-01

    Dysregulation of the endocannabinoid system (ECS) is a universal and, perhaps, causative feature of obesity. Central nervous system (CNS) circuits that regulate food intake were initially believed to be the targets for dysregulation. However, it is increasingly evident that endocannabinoids affect food intake, energy expenditure and substrate metabolism by acting on peripheral sites. Cannabinoid type 1 receptor (CB1r) antagonists can effectively treat obesity and associated metabolic alterations but, unfortunately, cause and exacerbate mood disorders. Drugs restricted to act on peripheral CB1rs might be safer and more effective, retaining the anti-obesity effects but lacking the adverse neurodepressive reactions. This review summarizes the emerging roles of the ECS in energy balance and discusses future pharmacological approaches for developing peripherally restricted CB1r antagonists.

  16. Influence of provider mix and regulation on primary care services supplied to US patients.

    PubMed

    Richards, Michael R; Polsky, Daniel

    2016-04-01

    Access to medical care and how it differs for various patients remain key policy issues. While existing work has examined clinic structure's influence on productivity, less research has explored the link between provider mix and access for different patient types - which also correspond to different service prices. We exploit experimental data from a large field study spanning 10 US states where trained audit callers were randomly assigned an insurance status and then contacted primary care physician practices seeking new patient appointments. We find clinics with more non-physician clinicians are associated with better access for Medicaid patients and lower prices for office visits; however, these relationships are only found in states granting full practice autonomy to these providers. Substituting more non-physician labor in primary care settings may facilitate greater appointment availability for Medicaid patients, but this likely rests on a favorable policy environment. Relaxing regulations for non-physicians may be an important initiative as US health reforms continue and also relevant to other countries coping with greater demands for medical care and related financial strain.

  17. Lipid sensing in the brain and regulation of energy balance.

    PubMed

    Moullé, V-S; Picard, A; Le Foll, C; Levin, B-E; Magnan, C

    2014-02-01

    Nutrient-sensitive neurons [to glucose and fatty acids (FAs)] are present at many sites throughout the brain, including the hypothalamus and brain stem, and play a key role in the neural control of energy and glucose homoeostasis. Through their neuronal output, FAs can modulate feeding behaviour as well as insulin secretion and activity. Central administration of oleate, for example, inhibits food intake and glucose production in rats. This suggests that daily variations in plasma FA concentrations could be detected by the central nervous system as a signal that contributes to regulation of energy balance. At the cellular level, subpopulations of neurons in the ventromedial and arcuate hypothalamic nuclei are selectively either inhibited or activated by FAs. Possible molecular effectors of these FA effects most likely include the chloride and potassium ion channels. While intracellular metabolism and activation of the ATP-sensitive K(+) channels appear to be necessary for some signalling effects of FAs, at least half the FA responses in ventromedial hypothalamic neurons are mediated by interaction with fatty acid translocase (FAT)/CD36, an FA transporter/receptor that does not require intracellular metabolism to activate downstream signalling. Thus, FAs and their metabolites can modulate neuronal activity by directly monitoring the ongoing fuel availability for brain nutrient-sensing neurons involved in the regulation of energy and glucose homoeostasis. Besides these physiological effects, FA overload or metabolic dysfunction may also impair neural control of energy homoeostasis and contribute to obesity and/or type 2 diabetes in predisposed subjects. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  18. Regulation of international energy markets: Economic effects of political actions

    NASA Astrophysics Data System (ADS)

    Shcherbakova, Anastasia V.

    Recent increases in volatility of energy prices have led many governments to reevaluate their regard of national energy reserves and reconsider future exploration, production, and consumption patterns. The flurry of activity that has been generated by such price volatility has included large-scale nationalizations of energy sectors, unilateral renegotiations of foreign energy development contracts, and expropriations of resources from foreign energy firms on one hand, and on the other hand more rapid energy sector liberalization, intensified search for and development of renewable fuels and technologies, and development of incentives for increased energy efficiency and conservation. The aim of this dissertation is to examine and quantify the extent of positive and negative effects that have resulted from some of these activities. The first chapter focuses on quantifying the effect that nationalistic sentiment has had on economic attractiveness of energy sectors during the decade prior to the recent global economic crisis, as measured by foreign direct investment (FDI) inflows. Empirical results demonstrate that both political and economic conditions play an important role in investors' decisions. A combination of investment friendliness, corruption levels, and democracy all help to explain the trends in energy-sector investment levels over time in my sample countries, although differences in the types of corruption existing in these nations do not. Investment levels, in turn, appear to influence future levels of oil production, underscoring the significance of good investment policies for future success of energy sectors. Chapter two considers the response of energy stock prices to severe regulatory actions. It employs an event study framework to examine causal effects of critical informational announcements (i.e. events of expropriation and nationalization) on daily returns and cumulative losses in firm value of energy corporations. Results show that a firm

  19. Impact of energy supply and oxygen transfer on selective lipopeptide production by Bacillus subtilis BBG21.

    PubMed

    Fahim, Sameh; Dimitrov, Krasimir; Gancel, Frederique; Vauchel, Peggy; Jacques, Philippe; Nikov, Iordan

    2012-12-01

    The influence of power dissipation and volumetric oxygen transfer coefficient k(L)a on Bacillus subtilis productivity of lipopeptides surfactin and fengycin was studied in shake flasks in view of scaling-up of this fermentation process. The experiments performed with different flask sizes, relative filling volumes, and shaking frequencies confirmed clearly that lipopeptide production changed in function of power dissipation, via interfacial gas-liquid contact surface and oxygen supply. It was demonstrated that k(L)a is the key parameter controlling the productivity and the selectivity of the bioreaction. Varying the oxygen transfer conditions, the synthesis could be oriented to mixed production or to surfactin mono-production. The fraction of surfactin towards total lipopeptides produced and the maximal surfactin production both increased with k(L)a increase (surfactin concentration about 2 g L(-1) at k(L)a=0.04-0.08 s(-1)), while the maximal fengycin production (fengycin concentration about 0.3 g L(-1)) was obtained at moderate oxygen supply (k(L)a=0.01 s(-1)). Copyright © 2012 Elsevier Ltd. All rights reserved.

  20. Daily magnesium fluxes regulate cellular timekeeping and energy balance

    PubMed Central

    Feeney, Kevin A.; Hansen, Louise L.; Putker, Marrit; Olivares-Yañez, Consuelo; Day, Jason; Eades, Lorna J.; Larrondo, Luis F.; Hoyle, Nathaniel P.; O'Neill, John S.; van Ooijen, Gerben

    2016-01-01

    Circadian clocks are fundamental to the biology of most eukaryotes, coordinating behavior and physiology to resonate with the environmental cycle of day and night through complex networks of clock-controlled genes1–3. A fundamental knowledge gap exists however, between circadian gene expression cycles and the biochemical mechanisms that ultimately facilitate circadian regulation of cell biology4,5. Here we report circadian rhythms in the intracellular concentration of magnesium ions, [Mg2+]i, which act as a cell-autonomous timekeeping component to determine key clock properties in both a human cell line and a unicellular alga that diverged from metazoans more than 1 billion years ago6. Given the essential role of Mg2+ as a cofactor for ATP, a functional consequence of [Mg2+]i oscillations is dynamic regulation of cellular energy expenditure over the daily cycle. Mechanistically, we find that these rhythms provide bilateral feedback linking rhythmic metabolism to clock-controlled gene expression. The global regulation of nucleotide triphosphate turnover by intracellular Mg2+ availability has potential to impact upon many of the cell’s >600 MgATP-dependent enzymes7 and every cellular system where MgNTP hydrolysis becomes rate limiting. Indeed, we find that circadian control of translation by mTOR8 is regulated through [Mg2+]i oscillations. It will now be important to identify which additional biological processes are subject to this form of regulation in tissues of multicellular organisms such as plants and humans, in the context of health and disease. PMID:27074515

  1. Optimal planning and design of a renewable energy based supply system for microgrids

    DOE PAGES

    Hafez, Omar; Bhattacharya, Kankar

    2012-03-03

    This paper presents a technique for optimal planning and design of hybrid renewable energy systems for microgrid applications. The Distributed Energy Resources Customer Adoption Model (DER-CAM) is used to determine the optimal size and type of distributed energy resources (DERs) and their operating schedules for a sample utility distribution system. Using the DER-CAM results, an evaluation is performed to evaluate the electrical performance of the distribution circuit if the DERs selected by the DER-CAM optimization analyses are incorporated. Results of analyses regarding the economic benefits of utilizing the optimal locations identified for the selected DER within the system are alsomore » presented. The actual Brookhaven National Laboratory (BNL) campus electrical network is used as an example to show the effectiveness of this approach. The results show that these technical and economic analyses of hybrid renewable energy systems are essential for the efficient utilization of renewable energy resources for microgird applications.« less

  2. Optimal planning and design of a renewable energy based supply system for microgrids

    SciTech Connect

    Hafez, Omar; Bhattacharya, Kankar

    2012-03-03

    This paper presents a technique for optimal planning and design of hybrid renewable energy systems for microgrid applications. The Distributed Energy Resources Customer Adoption Model (DER-CAM) is used to determine the optimal size and type of distributed energy resources (DERs) and their operating schedules for a sample utility distribution system. Using the DER-CAM results, an evaluation is performed to evaluate the electrical performance of the distribution circuit if the DERs selected by the DER-CAM optimization analyses are incorporated. Results of analyses regarding the economic benefits of utilizing the optimal locations identified for the selected DER within the system are also presented. The actual Brookhaven National Laboratory (BNL) campus electrical network is used as an example to show the effectiveness of this approach. The results show that these technical and economic analyses of hybrid renewable energy systems are essential for the efficient utilization of renewable energy resources for microgird applications.

  3. The role of short chain fatty acids in appetite regulation and energy homeostasis.

    PubMed

    Byrne, C S; Chambers, E S; Morrison, D J; Frost, G

    2015-09-01

    Over the last 20 years there has been an increasing interest in the influence of the gastrointestinal tract on appetite regulation. Much of the focus has been on the neuronal and hormonal relationship between the gastrointestinal tract and the brain. There is now mounting evidence that the colonic microbiota and their metabolic activity have a significant role in energy homeostasis. The supply of substrate to the colonic microbiota has a major impact on the microbial population and the metabolites they produce, particularly short chain fatty acids (SCFAs). SCFAs are produced when non-digestible carbohydrates, namely dietary fibres and resistant starch, undergo fermentation by the colonic microbiota. Both the consumption of fermentable carbohydrates and the administration of SCFAs have been reported to result in a wide range of health benefits including improvements in body composition, glucose homeostasis, blood lipid profiles and reduced body weight and colon cancer risk. However, published studies tend to report the effects that fermentable carbohydrates and SCFAs have on specific tissues and metabolic processes, and fail to explain how these local effects translate into systemic effects and the mitigation of disease risk. Moreover, studies tend to investigate SCFAs collectively and neglect to report the effects associated with individual SCFAs. Here, we bring together the recent evidence and suggest an overarching model for the effects of SCFAs on one of their beneficial aspects: appetite regulation and energy homeostasis.

  4. Improving government regulations: a guidebook for conservation and renewable energy

    SciTech Connect

    Neese, R. J.; Scheer, R. M.; Marasco, A. L.

    1981-04-01

    An integrated view of the Office of Conservation and Solar Energy (CS) policy making encompassing both administrative procedures and policy analysis is presented. Chapter One very briefly sketches each step in the development of a significant regulation, noting important requirements and participants. Chapter Two expands upon the Overview, providing the details of the process, the rationale and source of requirements, concurrence procedures, and advice on the timing and synchronization of steps. Chapter Three explains the types of analysis documents that may be required for a program. Regulatory Analyses, Environmental Impact Statements, Urban and Community Impact Analyses, and Regulatory Flexibility Analyses are all discussed. Specific information to be included in the documents and the circumstances under which the documents need to be prepared are explained. Chapter Four is a step-by-step discussion of how to do good analysis. Use of models and data bases is discussed. Policy objectives, alternatives, and decision making are explained. In Chapter five guidance is provided on identifying the public that would most likely be interested in the regulation, involving its constituents in a dialogue with CS, evaluating and handling comments, and engineering the final response. Chapter Six provides direction on planning the evaluation, monitoring the regulation's success once it has been promulgated, and allowing for constructive support or criticism from outside DOE. (MCW)

  5. Short-Term Energy Outlook Model Documentation: Hydrocarbon Gas Liquids Supply and Demand

    EIA Publications

    2015-01-01

    The hydrocarbon gas liquids (ethane, propane, butanes, and natural gasoline) module of the Short-Term Energy Outlook (STEO) model is designed to provide forecasts of U.S. production, consumption, refinery inputs, net imports, and inventories.

  6. Short-Term Energy Outlook Model Documentation: Hydrocarbon Gas Liquids Supply and Demand

    EIA Publications

    2015-01-01

    The hydrocarbon gas liquids (ethane, propane, butanes, and natural gasoline) module of the Short-Term Energy Outlook (STEO) model is designed to provide forecasts of U.S. production, consumption, refinery inputs, net imports, and inventories.

  7. Revitalization of Energy Supply Systems in the Scale of a Town, a District and an Island

    NASA Astrophysics Data System (ADS)

    Juchimiuk, Justyna

    2016-09-01

    Model actions undertaken in HafenCity and Wilhelmsburg during IBA Hamburg 2006- 13 as well as energy transformation of Danish island of Samsø towards self-sufficiency are examples of the use of energy as one of the key factors in the design of revitalization process in various scales. An important issue is to determine the impact of renewable energy systems on design process, architecture and urbanism of revitalized structures. Article examines the programs and projects related to the processes: renewal of degraded inner-industrial areas (brownfields), ecological restoration of degraded land, the revitalization of port and underdeveloped areas in the aspects of climate protection, the use of energy from renewable sources and improvement of technical conditions of building substance while maintaining the principles of sustainable development.

  8. Improving the energy and nutrient supply for common marmoset monkeys fed under long-term laboratory conditions.

    PubMed

    Mitura, A; Liebert, F; Schlumbohm, C; Fuchs, E

    2012-04-01

    Current knowledge about the optimal energy and nutrient supply for common marmoset monkeys (Callithrix jacchus) is scarce, and more information is needed for establishing the underlying nutritional concepts for facilitating longevity of this species as laboratory animals for biomedical research. Two feeding experiments were conducted to yield fundamental data about feed acceptance, real feed intake, and feed preferences under laboratory conditions. Newly developed feeding concepts for marmoset monkeys were also examined in preliminary investigations to compare the outcomes with those of a commercial pelletized mixed feed. The first experiments showed preferences for main protein sources in the diets studied, specifically that plant proteins are more accepted than fish meal or egg protein as the main protein source. Several aroma supplements did not modify the acceptance and feed intake markedly. The newly developed feeding concept yielded promising preliminary data for long-term studies of energy and nutrient supply under laboratory conditions. However, studies of the fundamental requirements are still needed. © 2011 Animal Nutrition Physiology.

  9. Brain lipoprotein lipase as a regulator of energy balance.

    PubMed

    Cruciani-Guglielmacci, Céline; Magnan, Christophe

    2017-07-24

    The central nervous system is an essential actor in the control of the energy balance. Indeed, many signals of nervous (vagal afferent for example) or circulating (hormone, nutrients) origin converge towards the brain to inform it permanently of the energetic status of the organism. In turn, the brain sends information to the periphery (sympathetic vagal balance, thyroid or corticotropic axis) which allows a fine regulation of the energy fluxes by acting on the hepatic glucose production, the secretion of the pancreatic hormones (glucagon, insulin) or food behavior. Among the nutrients, increasing amount of data assigns a signal molecule role to lipids such as fatty acids. These fatty acids may originate from the bloodstream but may also be the product of the hydrolysis of lipoproteins such as chylomicrons or VLDLs. Indeed, the identification of lipoprotein lipase (LPL) in the brain has led to the hypothesis that the LPL-dependent degradation of TG-enriched particles, and the addition of fatty acids, as informative molecules, to sensitive cells (neurons and/or astrocytes), plays a key role in maintaining the energy balance at equilibrium. Other lipases could also participate in these regulatory mechanisms. This review will summarize the state of the art and open up perspectives. Copyright © 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

  10. Models and mechanisms of energy balance regulation in the young.

    PubMed

    Mercer, Julian G

    2008-11-01

    The proportion of the child and adolescent population that is in appropriate energy balance is declining throughout the developed world, and childhood obesity is a particular problem in the UK relative to other northern European countries. Assessment of the underlying causes of obesity, and the different routes to its development, may assist in the definition of successful intervention strategies. The network of peripheral and central (brain) regulatory systems that underlie energy balance and body weight and composition can, for the most part, only be approached experimentally through the study of appropriate laboratory animal models. This problem is particularly acute when the target is overweight and obesity in the young. Some of the mechanisms underlying the development of energy imbalance and specifically the onset of overweight and obesity in the young, and the metabolic health consequences of obesity, can be addressed by examination of experimental rodent models in which mutation of a single gene causes early-onset extreme obesity, genetic susceptibility to obesity is revealed in an obesogenic environment or early-life nutritional experience programmes susceptibility to obesity or metabolic problems in later life. These studies highlight genes that are essential to normal body-weight regulation in rodents and man, the impact of diet and diet-induced obesity on regulatory systems in the young and the potential sensitivity of developing regulatory systems to nutritional experiences in utero and during early life.

  11. An Intelligent Approach to Strengthening of the Rural Electrical Power Supply Using Renewable Energy Resources

    NASA Astrophysics Data System (ADS)

    Robert, F. C.; Sisodia, G. S.; Gopalan, S.

    2017-08-01

    The healthy growth of economy lies in the balance between rural and urban development. Several developing countries have achieved a successful growth of urban areas, yet rural infrastructure has been neglected until recently. The rural electrical grids are weak with heavy losses and low capacity. Renewable energy represents an efficient way to generate electricity locally. However, the renewable energy generation may be limited by the low grid capacity. The current solutions focus on grid reinforcement only. This article presents a model for improving renewable energy integration in rural grids with the intelligent combination of three strategies: 1) grid reinforcement, 2) use of storage and 3) renewable energy curtailments. Such approach provides a solution to integrate a maximum of renewable energy generation on low capacity grids while minimising project cost and increasing the percentage of utilisation of assets. The test cases show that a grid connection agreement and a main inverter sized at 60 kW (resp. 80 kW) can accommodate a 100 kWp solar park (resp. 100 kW wind turbine) with minimal storage.

  12. Analysis of Time-of-Day Energy Demand and Supply in University and Hospital

    NASA Astrophysics Data System (ADS)

    Shimazaki, Yoichi

    The aim of this study was to estimate the time-of-day energy demand in University of Yamanashi. Our University consisted of Kofu campus (Faculty of Education & Human Sciences and Faculty of Engineering) and Faculty of Medicine campus (Faculty of Medicine and University Hospital). The energy data of 4 facilities were classified into hot water, heating, cooling and electric power demands based on electric power consumptions, city gas and heavy oil from 1996 to 2005. For 10 years, primary energy increased 1.2 times in the whole of the university. The amount of electric power consumption was 63% in the fuel classification. The amount of electric power consumption of faculty reacted to the change in temperature greatly. In 2005, it was found that thermoelectric-ratios for 4 facilities, i.e. Education, Engineering, Medicine and Hospital were 2.3, 1.5, 2.0 and 2.7 respectively. These data are very useful for the energy saving and energy management of university.

  13. Impact of forest biomass residues to the energy supply chain on regional air quality.

    PubMed

    Rafael, S; Tarelho, L; Monteiro, A; Sá, E; Miranda, A I; Borrego, C; Lopes, M

    2015-02-01

    The increase of the share of renewable energy in Portugal can be met from different sources, of which forest biomass residues (FBR) can play a main role. Taking into account the demand for information about the strategy of FBR to energy, and its implications on the Portuguese climate policy, the impact of energy conversion of FBR on air quality is evaluated. Three emission scenarios were defined and a numerical air quality model was selected to perform this evaluation. The results reveal that the biomass thermal plants contribute to an increment of the pollutant concentrations in the atmosphere, however restricted to the surrounding areas of the thermal plants, and most significant for NO₂ and O₃.

  14. Geothermal Program Review X: proceedings. Geothermal Energy and the Utility Market -- the Opportunities and Challenges for Expanding Geothermal Energy in a Competitive Supply Market

    SciTech Connect

    Not Available

    1992-01-01

    Each year the Geothermal Division of the US Department of Energy conducts an in-depth review of its entire geothermal R&D program. The conference serves several purposes: a status report on current R&D activities, an assessment of progress and problems, a review of management issues, and a technology transfer opportunity between DOE and the US geothermal city. This year`s conference, Program Review X, was held in San Francisco on March 24--26, 1992. The theme of the review, ``Geothermal Energy and the Utility Market -- The Opportunities and Challenges for Expanding Geothermal Energy in a Competitive Supply Market,`` focused on the needs of the electric utility sector. Geothermal energy, with its power capacity potential of 10 GWe by the year 2010, can provide reliable, enviromentally clean electricity which can help offset the projected increase in demand. Program Review X consisted of seven sessions including an opening session with presentations by Mr. Vikram Budhraja, Vice President of System Planning and Operations, Southern California Edison Company, and Mr. Richard Jaros, President and Chief Operating Officer, California Energy Company. The six technical sessions included presentations by the relevant field researchers covering DOE-sponsored R&D in hydrothermal, hot dry rock, and geopressured energy. Individual projects are processed separately for the data bases.

  15. 20% Wind Energy by 2030: Increasing Wind Energy's Contribution to U.S. Electricity Supply; Executive Summary (Revised)

    SciTech Connect

    Not Available

    2008-12-01

    This document is a 21-page summary of the 200+ page analysis that explores one clearly defined scenario for providing 20% of our nation's electricity demand with wind energy by 2030 and contrasts it to a scenario of no new U.S. wind power capacity.

  16. Re-energizing energy supply: Electrolytically-produced hydrogen as a flexible energy storage medium and fuel for road transport

    NASA Astrophysics Data System (ADS)

    Emonts, Bernd; Schiebahn, Sebastian; Görner, Klaus; Lindenberger, Dietmar; Markewitz, Peter; Merten, Frank; Stolten, Detlef

    2017-02-01

    "Energiewende", which roughly translates as the transformation of the German energy sector in accordance with the imperatives of climate change, may soon become a byword for the corresponding processes most other developed countries are at various stages of undergoing. Germany's notable progress in this area offers valuable insights that other states can draw on in implementing their own transitions. The German state of North Rhine-Westphalia (NRW) is making its own contribution to achieving the Energiewende's ambitious objectives: in addition to funding an array of 'clean and green' projects, the Virtual Institute Power to Gas and Heat was established as a consortium of seven scientific and technical organizations whose aim is to inscribe a future, renewable-based German energy system with adequate flexibility. Thus, it is tasked with conceiving of and evaluating suitable energy path options. This paper outlines one of the most promising of these pathways, which is predicated on the use of electrolytically-produced hydrogen as an energy storage medium, as well as the replacement of hydrocarbon-based fuel for most road vehicles. We describe and evaluate this path and place it in a systemic context, outlining a case study from which other countries and federated jurisdictions therein may draw inspiration.

  17. Energy storage and thermal control system design status. [for space station power supplies

    NASA Technical Reports Server (NTRS)

    Simons, Stephen N.; Willhoite, Bryan C.; Van Ommering, Gert

    1989-01-01

    The Space Station Freedom electric power system (EPS) will initially rely on photovoltaics for power generation and Ni/H2 batteries for electrical energy storage. The current design for the development status of two major subsystems in the PV Power Module is discussed. The energy storage subsystem comprised of high capacity Ni/H2 batteries and the single-phase thermal control system that rejects the excess heat generated by the batteries and other components associated with power generation andstorage is described.

  18. P.L. 100-357, "National Appliance Energy Supply Amendments" (1988)

    SciTech Connect

    2011-12-13

    Amends the Energy Policy and Conservation Act to include fluorescent lamp ballasts within the list of products covered by the Act. Amends the definition of "consumer product" to include fluorescent lamp ballasts distributed in commerce for personal or commercial use or consumption.

  19. U.S. Wind Energy Manufacturing & Supply Chain: A Competitive Analysis

    SciTech Connect

    Fullenkamp, Patrick

    2014-06-15

    The Global Wind Network (GLWN) assessed the key factors that determine wind energy component manufacturing costs and pricing on a global basis in order to provide a better understanding of the factors that will help enhance the competitiveness of U.S. manufacturers, and reduce installed system costs.

  20. The supply and energy potential of forest resources in northern Wisconsin and Michigan's Upper Peninsula.

    Treesearch

    Dennis P. Bradley; Eugene M. Carpenter; James A. Mattson; Jerold T. Hahn; Sharon A. Winsauer

    1980-01-01

    Analyzes the economic potential of achieving energy independence by 10 pulp and paper mills in northern Wisconsin and Upper Michigan. Independence would require the annual harvest of 5.79 million green tons for both fuel and fiber needs, compared to a recommended harvest level of 31 million green tons. Delivered wood cost projections seem well within affordable...

  1. Parental Influences on Children's Self-Regulation of Energy Intake: Insights from Developmental Literature on Emotion Regulation

    PubMed Central

    Frankel, Leslie A.; Hughes, Sheryl O.; O'Connor, Teresia M.; Power, Thomas G.; Fisher, Jennifer O.; Hazen, Nancy L.

    2012-01-01

    The following article examines the role of parents in the development of children's self-regulation of energy intake. Various paths of parental influence are offered based on the literature on parental influences on children's emotion self-regulation. The parental paths include modeling, responses to children's behavior, assistance in helping children self-regulate, and motivating children through rewards and punishments. Additionally, sources of variation in parental influences on regulation are examined, including parenting style, child temperament, and child-parent attachment security. Parallels in the nature of parents' role in socializing children's regulation of emotions and energy intake are examined. Implications for future research are discussed. PMID:22545206

  2. Regulation control and energy management scheme for wireless power transfer

    SciTech Connect

    Miller, John M.

    2015-12-29

    Power transfer rate at a charging facility can be maximized by employing a feedback scheme. The state of charge (SOC) and temperature of the regenerative energy storage system (RESS) pack of a vehicle is monitored to determine the load due to the RESS pack. An optimal frequency that cancels the imaginary component of the input impedance for the output signal from a grid converter is calculated from the load of the RESS pack, and a frequency offset f* is made to the nominal frequency f.sub.0 of the grid converter output based on the resonance frequency of a magnetically coupled circuit. The optimal frequency can maximize the efficiency of the power transfer. Further, an optimal grid converter duty ratio d* can be derived from the charge rate of the RESS pack. The grid converter duty ratio d* regulates wireless power transfer (WPT) power level.

  3. Regulation of Hepatic Energy Metabolism and Gluconeogenesis by BAD

    PubMed Central

    Giménez-Cassina, Alfredo; Garcia-Haro, Luisa; Choi, Cheol Soo; Osundiji, Mayowa A.; Lane, Elizabeth; Huang, Hu; Yildirim, Muhammed A.; Szlyk, Benjamin; Fisher, Jill K.; Polak, Klaudia; Patton, Elaura; Wiwczar, Jessica; Godes, Marina; Lee, Dae Ho; Robertson, Kirsten; Kim, Sheene; Kulkarni, Ameya; Distefano, Alberto; Samuel, Varman; Cline, Gary; Kim, Young-Bum; Shulman, Gerald I.; Danial, Nika N.

    2014-01-01

    SUMMARY The homeostatic balance of hepatic glucose utilization, storage and production is exquisitely controlled by hormonal signals and hepatic carbon metabolism during fed and fasted states. How the liver senses extracellular glucose to cue glucose utilization versus production is not fully understood. Here, we show that the physiologic balance of hepatic glycolysis and gluconeogenesis is regulated by BAD, a dual function protein with roles in apoptosis and metabolism. BAD deficiency reprograms hepatic substrate and energy metabolism towards diminished glycolysis, excess fatty acid oxidation and exaggerated glucose production that escapes suppression by insulin. Genetic and biochemical evidence suggest that BAD’s suppression of gluconeogenesis is actuated by phosphorylation of its BH3 domain and subsequent activation of glucokinase. The physiologic relevance of these findings is evident from the ability of a BAD phospho-mimic variant to counteract unrestrained gluconeogenesis and improve glycemia in leptin resistant and high-fat diet models of diabetes and insulin resistance. PMID:24506868

  4. An adipo-biliary-uridine axis that regulates energy homeostasis.

    PubMed

    Deng, Yingfeng; Wang, Zhao V; Gordillo, Ruth; An, Yu; Zhang, Chen; Liang, Qiren; Yoshino, Jun; Cautivo, Kelly M; De Brabander, Jef; Elmquist, Joel K; Horton, Jay D; Hill, Joseph A; Klein, Samuel; Scherer, Philipp E

    2017-03-17

    Uridine, a pyrimidine nucleoside present at high levels in the plasma of rodents and humans, is critical for RNA synthesis, glycogen deposition, and many other essential cellular processes. It also contributes to systemic metabolism, but the underlying mechanisms remain unclear. We found that plasma uridine levels are regulated by fasting and refeeding in mice, rats, and humans. Fasting increases plasma uridine levels, and this increase relies largely on adipocytes. In contrast, refeeding reduces plasma uridine levels through biliary clearance. Elevation of plasma uridine is required for the drop in body temperature that occurs during fasting. Further, feeding-induced clearance of plasma uridine improves glucose metabolism. We also present findings that implicate leptin signaling in uridine homeostasis and consequent metabolic control and thermoregulation. Our results indicate that plasma uridine governs energy homeostasis and thermoregulation in a mechanism involving adipocyte-dependent uridine biosynthesis and leptin signaling.

  5. Facing Water Scarcity in Jordan: Reuse, Demand Reduction, Energy and Transboundary Approaches to Assure Future Water Supplies

    NASA Astrophysics Data System (ADS)

    Scott, C. A.; El-Naser, H.; Hagan, R. E.; Hijazi, A.

    2001-05-01

    Jordan is extremely water-scarce with just 170 cubic meters per capita per year to meet domestic, industrial, agricultural, tourism, and environmental demands for water. Given the natural climatological conditions, demographic pressure, and transboundary nature of water resources, all renewable water resources of suitable quality are being exploited and some non-renewable aquifers are being depleted. The heavy exploitation of water resources has contributed to declines in the level of the Dead Sea. Rapid growth in demand, particularly for higher quality water for domestic, industrial and tourism uses, is significantly increasing pressure on agricultural and environmental uses of water, both of which must continue to adapt to reduced volumes and lower quality water. The agricultural sector has begun to respond by improving irrigation efficiency and increasing the use of recycled water. Total demand for water still exceeds renewable supplies while inadequate treatment of sewage used for irrigation creates potential environmental and health risks and presents agricultural marketing challenges that undermine the competitiveness of exports. The adaptive capability of the natural environment may already be past sustainable limits with groundwater discharge oasis wetlands that have been seriously affected. Development of new water resources is extremely expensive in Jordan with an average investment cost of US\\$ 4-5 per cubic meter. Integrated water resources management (IWRM) that incorporates factors external to the 'water sector' as conventionally defined will help to assure sustainable future water supplies in Jordan. This paper examines four IWRM approaches of relevance to Jordan: water reuse, demand management, energy-water linkages, and transboundary water management. While progress in Jordan has been made, the Ministry of Water and Irrigation continues to be concerned about the acute water scarcity the country faces as well as the need to continue working with

  6. The economic value of transportation energy contingency planning: An objective model for analyzing the economics of domestic renewable energy for supply augmentation

    NASA Astrophysics Data System (ADS)

    Shaten, Richard Jay

    1998-12-01

    Petroleum provides 90% of transportation energy needs. Domestic production is decreasing and global demand is increasing. Risk of escalating prices and supply interruptions are compounded by environmental and military externalities and lost opportunities from the failure to develop alternative domestic resources. Within the context of "energy contingency planning" municipalities should evaluate crisis mitigation strategies. Supply augmentation using domestic renewable fuels is proposed to avert future financial liabilities. A method for calculating the economic value of this strategy is demonstrated. An objective function and associated constraints represent the cost of preparing for each of three possible scenarios: status quo, inflationary and crisis. Constraints ensure that municipal fuel needs are met. Environmental costs may be included. Optimal solutions determine the fuel supply mix for each scenario. A 3 x 3 matrix presents the range of actual costs resulting from preparing for each scenario and subsequent three possible outcomes. The distribution of probabilities of the outcomes is applied to the cost matrix and an "expected value" of preparing for each scenario is calculated. An unanticipated crisis outcome results in. The expected value of the cost of preparing for a crisis is cast as an insurance premium against potential economic liability. Policy makers accept the crisis preparation fuel mix if: (a) they agree with the calculated penalty cost, or (b) they accept the burden of the insurance premium. Green Bay Wisconsin was chosen as a sample municipality. Results show that a perceived 10% chance of crisis requires an annual tax of 4.00 per household to avert economic impacts of 50 million. At a perceived 50% chance of crisis preparing for the crisis would begin to save the municipality money.

  7. Cancer: NF-κB regulates energy metabolism.

    PubMed

    Moretti, Marta; Bennett, Jason; Tornatore, Laura; Thotakura, Anil K; Franzoso, Guido

    2012-12-01

    NF-κB transcription factors are evolutionarily conserved, central coordinators of immune and inflammatory responses. They also play a pivotal role in oncogenesis. NF-κB exerts these functions by regulating the transcription of genes encoding many immunoregulators, inflammatory mediators and inhibitors of apoptosis. Several studies during the past few years have also underscored the key role of the IKK/NF-κB pathway in the induction and maintenance of the state of inflammation that underlies metabolic pathologies such as obesity, insulin resistance and type-2 diabetes, reflecting the co-evolution and integration of nutrient- and pathogen-sensing systems. Recent reports, however, are revealing an even more intimate, direct connection between NF-κB and metabolism. These studies demonstrate that NF-κB regulates energy homeostasis via direct engagement of the cellular networks governing glycolysis and respiration, with profound implications that extend beyond metabolic pathologies, to cellular physiology, cancer, and anti-cancer therapy. In this review article, we discuss these emerging metabolic functions of NF-κB and their significance to oncogenesis and cancer treatment.

  8. Central regulation of energy balance: inputs, outputs and leptin resistance.

    PubMed

    Arch, Jonathan R S

    2005-02-01

    The regulation of energy balance is complex and, in man, imprecise. Nevertheless, in many individuals intake and expenditure are balanced with <1% error with little or no conscious effect. Essential components of such a regulatory system are signals, leptin and insulin, that reflect the size of lipid stores. Leptin receptors signal via phosphatidylinositol 3-kinase (as do insulin receptors) and via the transcription factor signal transducer and activator of transcription-3 to activate various types of neurone. Obese rodents, and possibly man, are resistant to leptin; in some cases because of genetic or perinatal programming (primary resistance), but commonly in response to high leptin levels (secondary resistance). Secondary leptin resistance may be a result of reduced transport of leptin to the brain or down-regulation of leptin signalling. Signals that reflect lipid stores form the tonic homeostatic regulatory system. They interact with episodic homeostatic signals carried by neurones, hormones and metabolites to regulate meal size and frequency. They also interact with signals related to the palatability of food, biorhythms and learning. Many neurotransmitters and hormones mediate responses to more than one input (e.g. gastric and adipocyte leptin), but are nevertheless most involved with particular inputs (e.g. leptin with adipocyte fat stores). Feeding can be divided into appetitive (preparation for feeding) and consummatory phases, which can both be further subdivided. Different sets of neurotransmitters and hormones are involved at each stage. In the long term it may be possible to customise obesity therapies according to those inputs and outputs that are most disturbed and most amenable to intervention in individual subjects.

  9. Single Source Applicability Determination for Environmental Wood Supply, LLC and District Energy St. Paul, Inc

    EPA Pesticide Factsheets

    This document may be of assistance in applying the New Source Review (NSR) air permitting regulations including the Prevention of Significant Deterioration (PSD) requirements. This document is part of the NSR Policy and Guidance Database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  10. P.L. 100-12, "National Appliance Energy Supply Act" (1987)

    SciTech Connect

    2011-12-13

    Amends the Energy Policy and Conservation Act to add to the list of products covered under the Act: (1) freezers which can be operated by alternating current electricity (with specified exceptions); (2) central air conditioning heat pumps; (3) direct heating equipment; and (4) pool heaters. Deletes from specific coverage: (1) humidifiers; and (2) dehumidifiers. Excludes from such coverage consumer products designed solely for use in recreational vehicles and other mobile equipment.

  11. A presently available energy supply for high temperature environment (550-1000 deg F)

    NASA Technical Reports Server (NTRS)

    Jacquelin, J.; Vic, R. L.

    1981-01-01

    Sodium-sulfur cells attractive electric energy storage device for long service, are discussed. The state of art is given. More than 200 Wh/kg cells were tested. The known range of working temperature is 550 to 750 F. Self-discharge is quite nonexistent for months in operation. The technical basis for expecting an operating range up to 1,000 F under a high pressure atmosphere is given. Possibilities to adapt size and characteristics to particular interplanetary missions are discussed.

  12. Wind for Schools: Fostering the Human Talent Supply Chain for a 20% Wind Energy Future (Poster)

    SciTech Connect

    Baring-Gould, I.

    2011-03-01

    As the United States dramatically expands wind energy deployment, the industry is challenged with developing a skilled workforce and addressing public resistance. Wind Powering America's Wind for Schools project addresses these issues by: 1) Developing Wind Application Centers (WACs) at universities; WAC students assist in implementing school wind turbines and participate in wind courses. 2) Installing small wind turbines at community "host" schools. 3) Implementing teacher training with interactive curricula at each host school.

  13. Long integral temperature Brillouin sensor for off- shore wind energy power supply lines

    NASA Astrophysics Data System (ADS)

    Quintela, M. A.; Ullán, A.; Quintela, A.; Galindez, C.; Perez-Herrera, R. A.; López-Amo, M.; Lopez-Higuera, J. M.

    2011-05-01

    A hybrid Erbium-Brillouin fiber laser sensor to measure the temperature along 22 km fiber is proposed and experimentally demonstrated. A multi-line laser oscillation is induced by the Brillouin gain of different concatenated transducer fiber sections placed in the ring cavity. Integral temperature measurements of each fiber section are obtained through each laser line. This sensor can be used to monitor the temperature of off-shore wind energy power cables.

  14. Forward and pressure retarded osmosis: potential solutions for global challenges in energy and water supply.

    PubMed

    Klaysom, Chalida; Cath, Tazhi Y; Depuydt, Tom; Vankelecom, Ivo F J

    2013-08-21

    Osmotically driven membrane processes (ODMP) have gained renewed interest in recent years and they might become a potential solution for the world's most challenging problems of water and energy scarcity. Though the concept of utilizing osmotic pressure difference between high and low salinity streams across semipermeable membranes has been explored for several decades, lack of optimal membranes and draw solutions hindered competition between forward osmosis (FO) and pressure retarded osmosis (PRO) with existing water purification and power generation technologies, respectively. Driven by growing global water scarcity and by energy cost and negative environmental impacts, novel membranes and draw solutions are being developed for ODMPs, mass and heat transfer in osmotic process are becoming better understood, and new applications of ODMPs are emerging. Therefore, OMDPs might become promising green technologies to provide clean water and clean energy from abundantly available renewable resources. This review focuses primarily on new insights into osmotic membrane transport mechanisms and on novel membranes and draw solutions that are currently being developed. Furthermore, the effects of operating conditions on the overall performance of osmotic membranes will be highlighted and future perspectives will be presented.

  15. Red blood cell β-adrenergic receptors contribute to diet-induced energy expenditure by increasing O2 supply

    PubMed Central

    Kim, Eun Ran; Fan, Shengjie; Akhmedov, Dmitry; Sun, Kaiqi; Lim, Hoyong; O’Brien, William; Xu, Yuanzhong; Mangieri, Leandra R.; Zhu, Yaming; Lee, Cheng-Chi; Chung, Yeonseok; Xia, Yang; Xu, Yong; Li, Feng; Sun, Kai

    2017-01-01

    Diet-induced obesity (DIO) represents the major cause for the current obesity epidemic, but the mechanism underlying DIO is unclear. β-Adrenergic receptors (β-ARs) play a major role in sympathetic nervous system–mediated (SNS-mediated) diet-induced energy expenditure (EE). Rbc express abundant β-ARs; however, a potential role for rbc in DIO remains untested. Here, we demonstrated that high-fat, high-caloric diet (HFD) feeding increased both EE and blood O2 content, and the HFD-induced increases in blood O2 level and in body weight gain were negatively correlated. Deficiency of β-ARs in rbc reduced glycolysis and ATP levels, diminished HFD-induced increases in both blood O2 content and EE, and resulted in DIO. Importantly, specific activation of cAMP signaling in rbc promoted HFD-induced EE and reduced HFD-induced tissue hypoxia independent of obesity. Both HFD and pharmacological activation cAMP signaling in rbc led to increased glycolysis and ATP levels. These results identify a previously unknown role for rbc β-ARs in mediating the SNS action on HFD-induced EE by increasing O2 supply, and they demonstrate that HFD-induced EE is limited by blood O2 availability and can be augenmented by increased O2 supply. PMID:28724789

  16. Endocrine Regulation of Bone and Energy Metabolism in Hibernating Mammals

    PubMed Central

    Doherty, Alison H.; Florant, Gregory L.; Donahue, Seth W.

    2014-01-01

    Precise coordination among organs is required to maintain homeostasis throughout hibernation. This is particularly true in balancing bone remodeling processes (bone formation and resorption) in hibernators experiencing nutritional deprivation and extreme physical inactivity, two factors normally leading to pronounced bone loss in non-hibernating mammals. In recent years, important relationships between bone, fat, reproductive, and brain tissues have come to light. These systems share interconnected regulatory mechanisms of energy metabolism that potentially protect the skeleton during hibernation. This review focuses on the endocrine and neuroendocrine regulation of bone/fat/energy metabolism in hibernators. Hibernators appear to have unique mechanisms that protect musculoskeletal tissues while catabolizing their abundant stores of fat. Furthermore, the bone remodeling processes that normally cause disuse-induced bone loss in non-hibernators are compared to bone remodeling processes in hibernators, and possible adaptations of the bone signaling pathways that protect the skeleton during hibernation are discussed. Understanding the biological mechanisms that allow hibernators to survive the prolonged disuse and fasting associated with extreme environmental challenges will provide critical information regarding the limit of convergence in mammalian systems and of skeletal plasticity, and may contribute valuable insight into the etiology and treatment of human diseases. PMID:24556365

  17. Endocrine regulation of bone and energy metabolism in hibernating mammals.

    PubMed

    Doherty, Alison H; Florant, Gregory L; Donahue, Seth W

    2014-09-01

    Precise coordination among organs is required to maintain homeostasis throughout hibernation. This is particularly true in balancing bone remodeling processes (bone formation and resorption) in hibernators experiencing nutritional deprivation and extreme physical inactivity, two factors normally leading to pronounced bone loss in non-hibernating mammals. In recent years, important relationships between bone, fat, reproductive, and brain tissues have come to light. These systems share interconnected regulatory mechanisms of energy metabolism that potentially protect the skeleton during hibernation. This review focuses on the endocrine and neuroendocrine regulation of bone/fat/energy metabolism in hibernators. Hibernators appear to have unique mechanisms that protect musculoskeletal tissues while catabolizing their abundant stores of fat. Furthermore, the bone remodeling processes that normally cause disuse-induced bone loss in non-hibernators are compared to bone remodeling processes in hibernators, and possible adaptations of the bone signaling pathways that protect the skeleton during hibernation are discussed. Understanding the biological mechanisms that allow hibernators to survive the prolonged disuse and fasting associated with extreme environmental challenges will provide critical information regarding the limit of convergence in mammalian systems and of skeletal plasticity, and may contribute valuable insight into the etiology and treatment of human diseases. © The Author 2014. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

  18. Vermont Biofuels Initiative: Local Production for Local Use to Supply a Portion of Vermont's Energy Needs

    SciTech Connect

    Sawyer, Scott; Kahler, Ellen

    2009-05-31

    The Vermont Biofuels initiative (VBI) is the Vermont Sustainable Jobs Fund's (VSJF) biomass-to-biofuels market development program. Vermont is a small state with a large petroleum dependency for transportation (18th in per capita petroleum consumption) and home heating (55% of all households use petroleum for heating). The VBI marks the first strategic effort to reduce Vermont's dependency on petroleum through the development of homegrown alternatives. As such, it supports the four key priorities of the U.S. Department of Energy's Multi-year Biomass Plan: 1.) Dramatically reduce dependence on foreign oil; 2.) Promote the use of diverse, domestic and sustainable energy resources; 3.) Reduce carbon emissions from energy production and consumption; 4.) Establish a domestic bioindustry. In 2005 VSJF was awarded with a $496,000 Congressionally directed award from U.S. Senator Patrick Leahy. This award was administered through the U.S. Department of Energy (DE-FG36- 05GO85017, hereafter referred to as DOE FY05) with $396,000 to be used by VSJF for biodiesel development and $100,000 to be used by the Vermont Department of Public Service for methane biodigester projects. The intent and strategic focus of the VBI is similar to another DOE funded organization-the Biofuels Center of North Carolina-in that it is a nonprofit driven, statewide biofuels market development effort. DOE FY05 funds were expensed from 2006 through 2008 for seven projects: 1) a feedstock production, logistics, and biomass conversion research project conducted by the University of Vermont Extension; 2) technical assistance in the form of a safety review and engineering study of State Line Biofuels existing biodiesel production facility; 3) technical assistance in the form of a safety review and engineering study of Borderview Farm's proposed biodiesel production facility; 4) technology and infrastructure purchases for capacity expansion at Green Technologies, LLC, a waste vegetable biodiesel producer; 5

  19. Water supply for the Nuclear Rocket Development Station at the U.S. Atomic Energy Commission's Nevada Test Site

    USGS Publications Warehouse

    Young, Richard Arden

    1972-01-01

    The Nuclear Rocket Development Station, in Jackass Flats, occupies about 123 square miles in the southwestern part of the U.S. Atomic Energy Commission's Nevada Test Site. Jackass Flats, an intermontane valley bordered by highlands on all sides except for a drainage outlet in the southwestern corner, has an average annual rainfall of 4 inches. Jackass Flats is underlain by alluvium, colluvium, and volcanic rocks of Cenozoic age and, at greater depth, by sedimentary rocks of Paleozoic age. The alluvium and the colluvium lie above the saturated zone throughout nearly all of Jackass Flats. The Paleozoic sedimentary rocks contain limestone and dolomite units that are excellent water producers elsewhere ; however, these units are too deep in Jackass Flats to be economic sources of water. The only important water-producing unit known in the vicinity of the Nuclear Rocket Development Station is a welded-tuff aquifer, the Topopah Spring Member of the Paintbrush Tuff, which receives no significant recharge. This member contains about 500 feet of highly fractured rock underlying an area 11 miles long and 3 miles wide in western Jackass Flats. Permeability of the aquifer is derived mostly from joints and fractures; however, some permeability may be derived from gas bubbles in the upper part of the unit. Transmissivity, obtained from pumping tests, ranges from 68,000 to 488,000 gallons per day per foot. Volume of the saturated part of the aquifer is about 3.5 cubic miles, and the average specific yield probably ranges from 1 to 5 percent. The volume of ground water in storage is probably within the range of 37-187 billion gallons. This large amount of water should be sufficient to supply the needs of the Nuclear Rocket Development Station for many years. Water at the Nuclear Rocket Development Station is used for public supply, construction, test-cell coolant, exhaust cooling, and thermal shielding during nuclear reactor and engine testing, and washdown. Present (1967) average

  20. Energy supply of food processing plants and breweries from its specific solid wastes

    SciTech Connect

    Behmel, U.; Leupold, G.; Meyer-Pittroff, R.

    1993-12-31

    Disposal of solid wastes in the food processing industry causes problems. Constant utilization as animal food is not guaranteed any longer and costs for disposal will increase. Biogas production is an alternative for disposal of brewery wastes. Recent investigations have reduced retention time for hydrolysis and total retention time. Retention time is directly proportional to fermenter size consequently resulting in drastic cost reductions. Yielded energy can be utilized in the production line so that fossil fuel use can be reduced with reductions in carbon dioxide emissions. However, some problems remain: sumptous technology; highly qualified specialists; need to reduce ammonia to prevent inhibition of biogas production; cost of technology.

  1. A PFC power supply with minimized energy storage components and a new control technique for cascaded SMPS

    NASA Astrophysics Data System (ADS)

    Frost, Damien F.

    2009-12-01

    This Master of Applied Science thesis proposes a new design of low power, power factor corrected (PFC), power supplies. By lifting the hold up time restriction for devices that have a battery built in, the energy storage elements of the converter can be reduced, permitting a small and inexpensive power converter to be built. In addition, a new control technique for controlling cascaded converters is presented, named duty mode control (DMC). Its advantages are shown through simulations. The system was proven using a prototype developed in the laboratory designed for a universal ac input voltage (85 - 265 VRMS at 50 - 60Hz) and a 40W output at 12V . It consisted of two interleaved phases sensed and digitally controlled on the isolated side of the converter. The prototype was able to achieve a power factor of greater than 0.98 for all operating conditions, and input harmonic current distortion well below any set of standards.

  2. Technological development of high energy density capacitors. [for spacecraft power supplies

    NASA Technical Reports Server (NTRS)

    Parker, R. D.

    1976-01-01

    A study was conducted to develop cylindrical wound metallized film capacitors rated 2 micron F 500 VDC that had energy densities greater than 0.1J/g. Polysulfone (PS) and polyvinylidene (PVF2) were selected as dielectrics. Single film PS capacitors of 0.2J/g (uncased) were made of 3.75 micron material. Single film PVF2 capacitors of 0.19J/g (uncased) were made of 6.0 micron material. Corona measurements were made at room temperature, and capacitance and dissipation factor measurements were made over the ranges 25 C to 125 C and 120 Hz to 100 kHz. Nineteen of twenty PVF2 components survived a 2500 hour dc plus ac life test. Failure analyses revealed most failures occurred at wrinkles, but some edge failures were also seen. A 0.989g case was designed. When the case was combined with the PVF2 component, a finished energy density of 0.11J/g was achieved.

  3. Use of a turboexpander in steam power units for heat energy recovery in heat supply systems

    NASA Astrophysics Data System (ADS)

    Sadykov, R. A.; Daminov, A. Z.; Solomin, I. N.; Futin, V. A.

    2016-05-01

    A method for raising the efficiency of a boiler plant by installing a unit operating by the organic Rankine cycle is presented. Such units allow one to generate electricity to cover the auxiliaries of a heat source at a heat-transfer fluid temperature of no more than 130°C. The results of commissioning tests of boilers revealed that their efficiency is maximized under a load that is close or corresponds to the nominal one. If this load is maintained constantly, excess heat energy is produced. This excess may be used to generate electric energy in a steam power unit with a turboexpander. A way to insert this unit into the flow diagram of a boiler plant is proposed. The results of analysis of turbine types (turboexpanders included) with various capacities are presented, and the optimum type for the proposed flow diagram is chosen. The methodology for the design of turboexpanders and compressors used in the oil and gas industry and their operational data were applied in the analysis of a turboexpander. The results of the thermogasdynamic analysis of a turboexpander and the engineered shape of an axial-radial impeller are presented. Halocarbon R245fa is chosen as the working medium based on its calorimetric properties.

  4. Power supply

    DOEpatents

    Hart, Edward J.; Leeman, James E.; MacDougall, Hugh R.; Marron, John J.; Smith, Calvin C.

    1976-01-01

    An electric power supply employs a striking means to initiate ferroelectric elements which provide electrical energy output which subsequently initiates an explosive charge which initiates a second ferroelectric current generator to deliver current to the coil of a magnetic field current generator, creating a magnetic field around the coil. Continued detonation effects compression of the magnetic field and subsequent generation and delivery of a large output current to appropriate output loads.

  5. Effects of altered glucose supply and adiposity on expression of hypothalamic energy balance regulatory genes in late gestation growth restricted ovine fetuses.

    PubMed

    Adam, C L; Bake, T; Findlay, P A; Milne, J S; Aitken, R P; Wallace, J M

    2011-11-01

    Intra-uterine growth restriction (IUGR) predisposes obesity in adulthood. This may be due to altered fetal nutrition causing sustained changes within the developing hypothalamic energy balance regulatory system. Using our established ovine model of IUGR, 130-day singleton fetuses (term=147 days) were obtained from growing adolescent mothers on control dietary intake (C), high intake (H) or H with growth hormone administration during either early (H+early GH) or late gestation (H+late GH) (n=6/group). GH increased maternal glycemia for the duration of treatment. H and H+early GH fetuses showed IUGR compared with C fetuses; body weight was partially restored in H+late GH fetuses, with 40% increased adiposity. In the fetal hypothalamic arcuate nucleus (ARC), cocaine- and amphetamine-regulated transcript mRNA (anorexigenic) was decreased in H fetuses and correlated across all groups with total fetal liver glycogen. Neuropeptide Y, agouti-related peptide (orexigenic) and proopiomelanocortin (anorexigenic) mRNAs were not different between groups. Insulin receptor mRNA in the ARC was increased in H, H+early GH and H+late GH fetuses and correlated negatively with fetal plasma insulin. Leptin receptor mRNA in the ARC correlated positively with fetal plasma leptin concentration and fetal fat content. Therefore, in IUGR fetuses, a key anorexigenic neuropeptide is sensitive to altered glucose supply and the hypothalamic leptin-signaling pathway is altered prenatally by increased adiposity and leptinemia. These changes could impact on postnatal energy balance regulation. Copyright © 2011 ISDN. Published by Elsevier Ltd. All rights reserved.

  6. Linear magnetic motor/generator. [to generate electric energy using magnetic flux for spacecraft power supply

    NASA Technical Reports Server (NTRS)

    Studer, P. A. (Inventor)

    1982-01-01

    A linear magnetic motor/generator is disclosed which uses magnetic flux to provide mechanical motion or electrical energy. The linear magnetic motor/generator includes an axially movable actuator mechanism. A permament magnet mechanism defines a first magnetic flux path which passes through a first end portion of the actuator mechanism. Another permament magnet mechanism defines a second magnetic flux path which passes through a second end portion of the actuator mechanism. A drive coil defines a third magnetic flux path passing through a third central portion of the actuator mechanism. A drive coil selectively adds magnetic flux to and subtracts magnetic flux from magnetic flux flowing in the first and second magnetic flux path.

  7. Energy efficiency by use of automated energy-saving windows with heat-reflective screens and solar battery for power supply systems of European and Russian buildings

    NASA Astrophysics Data System (ADS)

    Zakharov, V. M.; Smirnov, N. N.; Tyutikov, V. V.; Flament, B.

    2015-10-01

    The new energy saving windows with heat-reflecting shields have been developed, and for their practical use they need to be integrated into the automated system for controlling heat supply in buildings and the efficiency of their use together with the existing energy-saving measures must be determined. The study was based on the results of field tests of windows with heat-reflective shields in a certified climate chamber. The method to determine the minimum indoor air temperature under standby heating using heat-reflective shields in the windows and multifunctional energy-efficient shutter with solar battery have been developed. Annual energy saving for the conditions of different regions of Russia and France was determined. Using windows with heat-reflecting screens and a solar battery results in a triple power effect: reduced heat losses during the heating season due to increased window resistance; lower cost of heating buildings due to lowering of indoor ambient temperature; also electric power generation.

  8. A non-autonomous optimal control model of renewable energy production under the aspect of fluctuating supply and learning by doing.

    PubMed

    Moser, Elke; Grass, Dieter; Tragler, Gernot

    Given the constantly raising world-wide energy demand and the accompanying increase in greenhouse gas emissions that pushes the progression of climate change, the possibly most important task in future is to find a carbon-low energy supply that finds the right balance between sustainability and energy security. For renewable energy generation, however, especially the second aspect turns out to be difficult as the supply of renewable sources underlies strong volatility. Further on, investment costs for new technologies are so high that competitiveness with conventional energy forms is hard to achieve. To address this issue, we analyze in this paper a non-autonomous optimal control model considering the optimal composition of a portfolio that consists of fossil and renewable energy and which is used to cover the energy demand of a small country. While fossil energy is assumed to be constantly available, the supply of the renewable resource fluctuates seasonally. We further on include learning effects for the renewable energy technology, which will underline the importance of considering the whole life span of such a technology for long-term energy planning decisions.

  9. Macroautophagy regulates energy metabolism during effector T cell activation.

    PubMed

    Hubbard, Vanessa M; Valdor, Rut; Patel, Bindi; Singh, Rajat; Cuervo, Ana Maria; Macian, Fernando

    2010-12-15

    Macroautophagy is a highly conserved mechanism of lysosomal-mediated protein degradation that plays a key role in maintaining cellular homeostasis by recycling amino acids, reducing the amount of damaged proteins, and regulating protein levels in response to extracellular signals. We have found that macroautophagy is induced after effector T cell activation. Engagement of the TCR and CD28 results in enhanced microtubule-associated protein 1 light chain 3 (LC3) processing, increased numbers of LC3-containing vesicles, and increased LC3 flux, indicating active autophagosome formation and clearance. The autophagosomes formed in stimulated T cells actively fuse with lysosomes to degrade their cargo. Using a conditional KO mouse model where Atg7, a critical gene for macroautophagy, is specifically deleted in T cells, we have found that macroautophagy-deficient effector Th cells have defective IL-2 and IFN-γ production and reduced proliferation after stimulation, with no significant increase in apoptosis. We have found that ATP generation is decreased when autophagy is blocked, and defects in activation-induced cytokine production are restored when an exogenous energy source is added to macroautophagy-deficient T cells. Furthermore, we present evidence showing that the nature of the cargo inside autophagic vesicles found in resting T cells differs from the cargo of autophagosomes in activated T cells, where mitochondria and other organelles are selectively excluded. These results suggest that macroautophagy is an actively regulated process in T cells that can be induced in response to TCR engagement to accommodate the bioenergetic requirements of activated T cells.

  10. An Aquifer Thermal Energy Storage (ATES) System for Continuous and Sustainable Cold Supply in Oman

    NASA Astrophysics Data System (ADS)

    Winterleitner, G.; Schütz, F.; Huenges, E.

    2016-12-01

    The aim of the GeoSolCool research programme between the German Research Centre for Geoscience (GFZ) and The Research Council of Oman (TRC) is the development of an innovative and sustainable cooling system in combination with an aquifer thermal energy storage system in northern Oman. An integral part of this project is the design of a subsurface aquifer reservoir system for storage of thermal energy through hot water injection. An accurate characterisation of potential storage horizons is thus essential to ensure optimal efficiency of the cooling system. The study area, 40 km west of Muscat is characterised by a thick Cenozoic mixed carbonate-siliciclastic sedimentary succession, containing at least 3 aquifer horizons. We used a multidisciplinary approach for the initial ATES development phase, including geological fieldwork dovetailed with remote sensing analyses, thin-section analyses, geological modelling and reservoir fluid flow forecasting. First results indicate two potential storage horizons: (1) a Miocene-aged clastic-dominated alluvial fan system and (2) an Eocene carbonate sequence. The alluvial fan system is a more than 300 m thick, coarse clastic (mainly gravels and sandstones) succession of coalesced individual fans. Thin-section analyses showed that hydraulic parameters are favourable for the gravel and sandstone intervals but reservoir architecture is complex due to multiple generations of interconnecting fans with highly heterogeneous facies distributions. The Eocene carbonates were deposited in a carbonate ramp setting, strongly influenced by currents and storm events. Individual facies belts extend over kilometres and thus horizontal reservoir connectivity is expected to be good with minor facies variability. Thin-section analyses showed that especially the fossil-rich sections show good storage qualities. Fluid flow forecasting indicate that both potential horizons have good to very good storage characteristics. However, intense diagenetic

  11. Biofuels in the long-run global energy supply mix for transportation.

    PubMed

    Timilsina, Govinda R

    2014-01-13

    Various policy instruments along with increasing oil prices have contributed to a sixfold increase in global biofuels production over the last decade (2000-2010). This rapid growth has proved controversial, however, and has raised concerns over potential conflicts with global food security and climate change mitigation. To address these concerns, policy support is now focused on advanced or second-generation biofuels instead of crop-based first-generation biofuels. This policy shift, together with the global financial crisis, has slowed the growth of biofuels production, which has remained stagnant since 2010. Based upon a review of the literature, this paper examines the potential long-run contribution of biofuels to the global energy mix, particularly for transportation. We find that the contribution of biofuels to global transportation fuel demand is likely to be limited to around 5% over the next 10-15 years. However, a number of studies suggest that biofuels could contribute up to a quarter of global transportation fuel demand by 2050, provided technological breakthroughs reduce the costs of sustainably produced advanced biofuels to a level where they can compete with petroleum fuels.

  12. SUPPLY AND DEMAND IN CEREBRAL ENERGY METABOLISM: THE ROLE OF NUTRIENT TRANSPORTERS

    PubMed Central

    Simpson, Ian A.; Carruthers, Anthony; Vannucci, Susan J.

    2007-01-01

    Glucose is the obligate energetic fuel for the mammalian brain and most studies of cerebral energy metabolism assume that the vast majority of cerebral glucose utilization fuels neuronal activity via oxidative metabolism, both in the basal and activated state. Glucose transporter proteins (GLUTs) deliver glucose from the circulation to the brain: GLUT1 in the microvascular endothelial cells of the blood brain barrier (BBB) and glia; GLUT3 in neurons. Lactate, the glycolytic product of glucose metabolism, is transported into and out of neural cells by the monocarboxylate transporters: MCT1 in the BBB and astrocytes and MCT2 in neurons. The proposal of the astrocyte-neuron lactate shuttle hypothesis (Pellerin and Magistretti, 1994) suggested that astrocytes play the primary role in cerebral glucose utilization and generate lactate for neuronal energetics, especially during activation. Since the identification of the GLUTs and MCTs in brain, much has been learned about their transport properties, i.e. capacity and affinity for substrate, which must be considered in any model of cerebral glucose uptake and utilization. Using concentrations and kinetic parameters of GLUT1 and GLUT3 in BBB endothelial cells, astrocytes and neurons, along with the corresponding kinetic properties of the monocarboxylate transporters, we have successfully modeled brain glucose and lactate levels as well as lactate transients in response to neuronal stimulation. Simulations based on these parameters suggest that glucose readily diffuses through the basal lamina and interstitium to neurons, which are primarily responsible for glucose uptake, metabolism, and the generation of the lactate transients observed upon neuronal activation. PMID:17579656

  13. [Breast hormones--regulators of energy homeostasis: growth of infants].

    PubMed

    Kon', I Ia; Shilina, N M; Gmoshinskaia, M V; Ivanushkina, T A

    2011-01-01

    Studied the possible relationship between the growth rate of children who are breastfed, and the level of protein, fat, insulin-like growth factor- 1 (IGF-1), ghrelin, leptin, adiponectin in breast milk. Examined 71 pair--a mother and a healthy child, who is breastfed. All infants were divided into 3 groups: low, normal and high weight gain. Daily breast milk intake, the level of fat, protein and hormones proteins regulators of energy homeostasis (adiponectin, grelin, IGF-1 and leptin) in breast milk were measured at 1, 2 and 3 months of lactation. It was found that daily breast milk consumption was higher in the group of infants with high weight gain and the content of protein and fat in it did not differ in three groups. Total daily consumption of protein and fat with breast milk was higher in groups of infants with high weight gain. There was significantly higher IGF-1 level and the tendency to higher grelin level in breast milk of mothers of infants with higher weight gain. The possible link of breast milk hormones with growth velocity of breast-fed infants is discussed.

  14. Hydro, wind and solar power as a base for a 100% renewable energy supply for South and Central America

    PubMed Central

    Barbosa, Larissa de Souza Noel Simas; Bogdanov, Dmitrii; Vainikka, Pasi; Breyer, Christian

    2017-01-01

    Power systems for South and Central America based on 100% renewable energy (RE) in the year 2030 were calculated for the first time using an hourly resolved energy model. The region was subdivided into 15 sub-regions. Four different scenarios were considered: three according to different high voltage direct current (HVDC) transmission grid development levels (region, country, area-wide) and one integrated scenario that considers water desalination and industrial gas demand supplied by synthetic natural gas via power-to-gas (PtG). RE is not only able to cover 1813 TWh of estimated electricity demand of the area in 2030 but also able to generate the electricity needed to fulfil 3.9 billion m3 of water desalination and 640 TWhLHV of synthetic natural gas demand. Existing hydro dams can be used as virtual batteries for solar and wind electricity storage, diminishing the role of storage technologies. The results for total levelized cost of electricity (LCOE) are decreased from 62 €/MWh for a highly decentralized to 56 €/MWh for a highly centralized grid scenario (currency value of the year 2015). For the integrated scenario, the levelized cost of gas (LCOG) and the levelized cost of water (LCOW) are 95 €/MWhLHV and 0.91 €/m3, respectively. A reduction of 8% in total cost and 5% in electricity generation was achieved when integrating desalination and power-to-gas into the system. PMID:28329023

  15. Hydro, wind and solar power as a base for a 100% renewable energy supply for South and Central America.

    PubMed

    Barbosa, Larissa de Souza Noel Simas; Bogdanov, Dmitrii; Vainikka, Pasi; Breyer, Christian

    2017-01-01

    Power systems for South and Central America based on 100% renewable energy (RE) in the year 2030 were calculated for the first time using an hourly resolved energy model. The region was subdivided into 15 sub-regions. Four different scenarios were considered: three according to different high voltage direct current (HVDC) transmission grid development levels (region, country, area-wide) and one integrated scenario that considers water desalination and industrial gas demand supplied by synthetic natural gas via power-to-gas (PtG). RE is not only able to cover 1813 TWh of estimated electricity demand of the area in 2030 but also able to generate the electricity needed to fulfil 3.9 billion m3 of water desalination and 640 TWhLHV of synthetic natural gas demand. Existing hydro dams can be used as virtual batteries for solar and wind electricity storage, diminishing the role of storage technologies. The results for total levelized cost of electricity (LCOE) are decreased from 62 €/MWh for a highly decentralized to 56 €/MWh for a highly centralized grid scenario (currency value of the year 2015). For the integrated scenario, the levelized cost of gas (LCOG) and the levelized cost of water (LCOW) are 95 €/MWhLHV and 0.91 €/m3, respectively. A reduction of 8% in total cost and 5% in electricity generation was achieved when integrating desalination and power-to-gas into the system.

  16. 10 CFR 603.695 - Requirements for supplies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Requirements for supplies. 603.695 Section 603.695 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Award Terms Affecting Participants' Financial, Property, and Purchasing Systems Property § 603.695 Requirements for...

  17. 10 CFR 603.695 - Requirements for supplies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Requirements for supplies. 603.695 Section 603.695 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Award Terms Affecting Participants' Financial, Property, and Purchasing Systems Property § 603.695 Requirements for...

  18. Analyzing opportunities for energy conservation in municipal fleet management: service delivery patterns, equipment, supply, operations, and maintenance. Information bulletin of the energy task force of the urban consortium

    SciTech Connect

    1980-01-01

    Vehicle fleet management as a five-step process is portrayed and the multiple energy conservation opportunities within each step are examined. The five steps described are, configuration of service area and service delivery patterns, equipping the fleet, operating the fleet, maintaining the fleet, and supplying the fleet with fuel. A systems approach to decision making about municipal fleets is outlined. Management options, control techniques, and devices are suggested for each of the five steps. Reference is made to analytic tools which will assist in deliberating options at each of these steps. These tools are presented in a list. Four concise case studies of jurisdictions which are taking deliberate steps to reduce fuel use are presented. Key opportunities for fuel conservation are then summarized, followed by a selected bibliography, and listing of reference materials and additional resources.

  19. Effects of prepartal body condition score and peripartal energy supply of dairy cows on postpartal lipolysis, energy balance and ketogenesis: an animal model to investigate subclinical ketosis.

    PubMed

    Schulz, Kirsten; Frahm, Jana; Meyer, Ulrich; Kersten, Susanne; Reiche, Dania; Rehage, Jürgen; Dänicke, Sven

    2014-08-01

    Subclinical ketosis is a metabolic disorder which often goes undiagnosed and leads to constricted performance and an impairment of general condition. In the current study subclinical ketosis was characterised by a β-hydroxybutyrate (BHB) concentration of >1·2 mmol/l in blood serum. To generate this metabolic situation, an animal model was created. The model, based on group-specific interaction of dietary energy supply and body condition, is appropriate for testing the medical effectiveness of treating this kind of ketosis and its concomitants. During the trial, 18 dairy cows (primiparous and pluriparous) were assigned, according to their body condition score (BCS) 6 weeks before expected parturition, to a normal [6.78 MJ net energy for lactation (NEL)/kg dry matter; 20% concentrate] or to a high-energy feeding group (7·71 MJ NEL/kg dry matter; 60% concentrate). Therefore cows with the highest BCS were allocated to the high-energy group to enhance the contrast with the control group. Statistical analysis was done using the MIXED procedure of SAS. Effects were declared significant when P-values were ⩽0.05. Owing to the higher energy concentration and dry matter intake, the energy intake and balance was significantly higher in the high-energy feeding group, with strong effects on lipid metabolism and health in blood and liver post partum. Within the first 2 weeks after calving, 8 out of 9 cows (89%) of the high-energy group had BHB values indicative of subclinical ketosis. These cows also had significantly higher values of non-esterified fatty acids (NEFA), aspartate transaminase (AST) and glutamate dehydrogenase (GLDH) post partum, as well as a raised total lipid content of the liver. RQUICKI, a calculated parameter which is based on serum concentrations of glucose, insulin and NEFA to assess the insulin sensitivity, was not affected by treatment. Therefore, RQUICKI does not seem to be the right parameter for diagnosing decreased insulin sensitivity in cows

  20. Impaired mitochondrial energy supply coupled to increased H2O2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes.

    PubMed

    Tocchetti, Carlo G; Stanley, Brian A; Sivakumaran, Vidhya; Bedja, Djahida; O'Rourke, Brian; Paolocci, Nazareno; Cortassa, Sonia; Aon, Miguel A

    2015-10-01

    In Type I diabetic (T1DM) patients, both peaks of hyperglycaemia and increased sympathetic tone probably contribute to impair systolic and diastolic function. However, how these stressors eventually alter cardiac function during T1DM is not fully understood. In the present study, we hypothesized that impaired mitochondrial energy supply and excess reactive oxygen species (ROS) emission is centrally involved in T1DM cardiac dysfunction due to metabolic/redox stress and aimed to determine the mitochondrial sites implicated in these alterations. To this end, we used isolated myocytes and mitochondria from Sham and streptozotocin (STZ)-induced T1DM guinea pigs (GPs), untreated or treated with insulin. Relative to controls, T1DM myocytes exhibited higher oxidative stress when challenged with high glucose (HG) combined with β-adrenergic stimulation [via isoprenaline (isoproterenol) (ISO)], leading to contraction/relaxation deficits. T1DM mitochondria had decreased respiration with complex II and IV substrates and markedly lower ADP phosphorylation rates and higher H2O2 emission when challenged with oxidants to mimic the more oxidized redox milieu present in HG + ISO-treated cardiomyocytes. Since in T1DM hearts insulin-sensitivity is preserved and a glucose-to-fatty acid (FA) shift occurs, we next tested whether insulin therapy or acute palmitate (Palm) infusion prevents HG + ISO-induced cardiac dysfunction. We found that insulin rescued proper cardiac redox balance, but not mitochondrial respiration or contractile performance. Conversely, Palm restored redox balance and preserved myocyte function. Thus, stressors such as peaks of HG and adrenergic hyperactivity impair mitochondrial respiration, hampering energy supply while exacerbating ROS emission. Our study suggests that an ideal therapeutic measure to treat metabolically/redox-challenged T1DM hearts should concomitantly correct energetic and redox abnormalities to fully maintain cardiac function.

  1. MicroRNAs regulate the main events in rice drought stress response by manipulating the water supply to shoots.

    PubMed

    Fard, Ehsan Mohseni; Bakhshi, Behnam; Farsi, Mohammad; Kakhki, Amin Mirshamsi; Nikpay, Nava; Ebrahimi, Mohammad Ali; Mardi, Mohsen; Salekdeh, Ghasem Hosseini

    2017-09-05

    MicroRNAs (miRNAs) are small endogenous regulatory RNAs that are involved in a variety of biological processes related to proliferation, development, and response to biotic and abiotic stresses. miRNA profiles of rice (Oryza sativa L. cv. IR64.) leaves in a partial root zone drying (PRD) system were analysed using a high-throughput sequencing approach to identify miRNAs associated with drought signalling. The treatments performed in this study were as follows: well-watered ("wet" roots, WW), wherein both halves of the pot were watered daily; drought ("dry" roots, DD), wherein water was withheld from both halves of the pot; and well-watered/drought ("wet" and "dry" roots, WD), wherein one half of each pot was watered daily, the same as in WW, and water was withheld from the other part, the same as in DD. High-throughput sequencing enabled us to detect novel miRNAs and study the differential expression of known miRNAs. A total of 209 novel miRNAs were detected in this study. Differential miRNA profiling of the DD, WD and WW conditions showed differential expression of 159 miRNAs, among which 83, 44 and 32 miRNAs showed differential expression under both DD and WD conditions. The detection of putative targets of the differentially expressed miRNAs and investigation of their functions showed that most of these genes encode transcription factors involved in growth and development, leaf morphology, regulation of hormonal homeostasis, and stress response. The most important differences between the DD and WD conditions involved regulation of the levels of hormones such as auxin, cytokinin, abscisic acid, and jasmonic acid and also regulation of phosphor homeostasis. Overall, differentially expressed miRNAs under WD conditions were found to differ from those under DD conditions, with such differences playing a role in adaptation and inducing the normal condition. The mechanisms involved in regulating hormonal homeostasis and involved in energy production and consumption

  2. Governmental regulation in the sector of alternative energy sources: some pros and cons

    SciTech Connect

    Grivoyannis, E.C.

    1983-12-01

    The energy crisis of the 1970s has lead to a demand for increased regulation of the energy sector by certain governments for several reasons. Increased regulation is viewed as a means of assuring access to alternative energy sources for all people. This is the welfare argument. Regulation is also viewed as a means of rationalizing the system of energy delivery. This is the efficiency argument. Under this traditional view of regulation the prices and profits of the regulated energy industry are expected to be lower and the allocation of energy sources more efficient. However, this traditional view of alternative energy source regulation is not without flaw. Firms of the energy producing industry can use several methods to ''capture'' established regulatory agencies and ''force'' them to ''regulate'' the dissatisfaction of the general public rather than the behavior of the firms. As a result, regulatory agencies can formulate decisions that are approximate to what the regulated energy industry desires instead of what the public expects. This paper will apply the arguments of the capture theory and the theory of political-economy for regulatory agencies in the alternative energy sources sector. Further, it will analyze a firm's behavior under uncertainty about demand and cost conditions. These conditions make it difficult for regulatory agencies to force a monopoly to make competitive investment and output decisions. Finally, it will discuss some of the problems associated with cost-benefit analysis which is widely used by regulatory agencies in their decision-making process.

  3. Parental influences on children's self-regulation of energy intake: Insights from developmental literature on emotion regulation

    USDA-ARS?s Scientific Manuscript database

    This article examines the role of parents in the development of children's self-regulation of energy intake. Various paths of parental influence are offered based on the literature on parental influences on children's emotion self-regulation. The parental paths include modeling, responses to childre...

  4. Energy-effective method for low-temperature deaeration of make-up water on the heating supply system of heat power plants

    NASA Astrophysics Data System (ADS)

    Sharapov, V. I.; Pazushkina, O. V.; Kudryavtseva, E. V.

    2016-01-01

    The technology for low-temperature deaeration of make-up water of heating supply systems is developed that makes it possible to substantially enhance the energy efficiency of heat power plants (HPPs). As a desorbing agent for deaeration of make-up water of heating supply systems, it is proposed to use not steam or superheated water but a gas supplied to boiler burners. Natural gas supplied to steam boilers of HPPs has very low or often negative temperature after reducing devices. At the same time, it is virtually corrosive gas-free (oxygen and carbon dioxide) and, therefore, can be successfully used as the desorbing agent for water deaeration. These factors make it possible to perform deaeration of make-up water of heating supply systems at relatively low temperatures (10-30°C). Mixing of the cold deaerated make-up water with the return delivery water results in a significant decrease in the temperature the return delivery water before a lower delivery heater of a dual-purpose turbine plant, increase in the power output with the heat consumption, and, consequently, enhancement in the operation efficiency of the HPP. The article presents the calculation of the consumption of gas theoretically required for deaeration and reveals the evaluation of the energy efficiency of the technology for a typical energy unit of thermal power station. The mass transfer efficiency of the deaeration of the make-up water of heating supply systems is estimated for the case of using natural gas as the desorbing agent for which the specific gas consumption required theoretically for deaeration is calculated. It is shown that the consumption of natural gas used as fuel in boilers of HPPs is sufficient for the deaeration of any volumes of the make-up water of heating supply systems. The energy efficiency of the developed technology is evaluated for a typical heat power-generating unit of the HPP with a T-100-12.8 turbine. The calculation showed that the application of the new technology

  5. Global energy regulation in the solar wind-magnetosphere-ionosphere system

    NASA Technical Reports Server (NTRS)

    Sato, T.

    1985-01-01

    Some basic concepts which are essential in the understanding of global energy regulation in the solar wind-magnetosphere-ionosphere system are introduced. The importance of line-tying concept is particularly emphasized in connection with the solar wind energy, energy release in the magnetosphere and energy dissipation in the ionosphere.

  6. Comparison of Test Procedures and Energy Efficiency Criteria in Selected International Standards & Labeling Programs for Copy Machines, External Power Supplies, LED Displays, Residential Gas Cooktops and Televisions

    SciTech Connect

    Zheng, Nina; Zhou, Nan; Fridley, David

    2012-03-01

    This report presents a technical review of international minimum energy performance standards (MEPS), voluntary and mandatory energy efficiency labels and test procedures for five products being considered for new or revised MEPS in China: copy machines, external power supply, LED displays, residential gas cooktops and flat-screen televisions. For each product, an overview of the scope of existing international standards and labeling programs, energy values and energy performance metrics and description and detailed summary table of criteria and procedures in major test standards are presented.

  7. A simple model for the energy supply of a stand-alone house using a hybrid wind-solar power system

    NASA Astrophysics Data System (ADS)

    Beke, Tamas

    2016-01-01

    A research project for secondary school students involving both physical measurements and modelling is presented. The problem to be solved is whether and how a typical house can be supplied with energy off-grid, based entirely on renewable energy sources, more specifically, on solar and wind energy, while using relatively simple devices, namely, photovoltaic modules, wind turbines and accumulators. To this end our students carried out a long term measurement series in order to assess the typical energy consumption of houses. Further, the number of solar modules and wind turbines, and the necessary accumulator capacity, was estimated.

  8. Creatine kinase adenosine triphosphate and phosphocreatine energy supply in a single kindred of patients with hypertrophic cardiomyopathy.

    PubMed

    Abraham, M Roselle; Bottomley, Paul A; Dimaano, Veronica Lea; Pinheiro, Aurelio; Steinberg, Angela; Traill, Thomas A; Abraham, Theodore P; Weiss, Robert G

    2013-09-15

    A lethal and extensively characterized familial form of hypertrophic cardiomyopathy (HC) is due to a point mutation (Arg403Gln) in the cardiac β-myosin heavy chain gene. Although this is associated with abnormal energy metabolism and progression to heart failure in an animal model, in vivo cardiac energetics have not been characterized in patients with this mutation. Noninvasive phosphorus saturation transfer magnetic resonance spectroscopy was used to measure the adenosine triphosphate supplied by the creatine kinase (CK) reaction and phosphocreatine, the heart's primary energy reserve, in 9 of 10 patients from a single kindred with HC caused by the Arg403GIn mutation and 17 age-matched healthy controls. Systolic and diastolic function was assessed by echocardiography in all 10 patients with HC. The patients with HC had impairment of diastolic function and mild systolic dysfunction, when assessed using global systolic longitudinal strain. Myocardial phosphocreatine was significantly decreased by 24% in patients (7.1 ± 2.3 μmol/g) compared with the controls (9.4 ± 1.2 μmol/g; p = 0.003). The pseudo-first-order CK rate-constant was 26% lower (0.28 ± 0.15 vs 0.38 ± 0.07 s⁻¹, p = 0.035) and the forward CK flux was 44% lower (2.0 ± 1.4 vs 3.6 ± 0.9 μmol/g/s, p = 0.001) than in the controls. The contractile abnormalities did not correlate with the metabolic indexes. In conclusion, myocardial phosphocreatine and CK-ATP delivery are significantly reduced in patients with HC caused by the Arg403Gln mutation, akin to previous results from mice with the same mutation. A lack of a relation between energetic and contractile abnormalities suggests the former result from the sarcomeric mutation and not a late consequence of mechanical dysfunction. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. IMPROVING ENERGY EFFICIENCY AND REDUCING COSTS IN THE DRINKING WATER SUPPLY INDUSTRY: An ENERGY STAR Resource Guide for Energy and Plant Managers

    SciTech Connect

    Melody, Moya; Dunham Whitehead, Camilla; Brown, Richard

    2010-09-30

    As American drinking water agencies face higher production costs, demand, and energy prices, they seek opportunities to reduce costs without negatively affecting the quality of the water they deliver. This guide describes resources for cost-effectively improving the energy efficiency of U.S. public drinking water facilities. The guide (1) describes areas of opportunity for improving energy efficiency in drinking water facilities; (2) provides detailed descriptions of resources to consult for each area of opportunity; (3) offers supplementary suggestions and information for the area; and (4) presents illustrative case studies, including analysis of cost-effectiveness.

  10. Overview of the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market - The Opportunities and Challenges for Expanding Geothermal Energy in a Competitive Supply Market

    SciTech Connect

    Mock, John E.; Budraja, Vikram; Jaros, Richard; Yamaguchi, Tsutomu; Hinrichs, Thomas C.

    1992-01-01

    This overview at the Geothermal Program Review X: Geothermal Energy and the Utility Market consisted of five presentations: ''Technology Advancements to Support Growth in Geothermal Power Sales in a Dynamic Utility Market'' by John E. Mock; ''Geothermal Energy Market in Southern California: Past, Present and Future'' by Vikram Budraja; ''Taking the High Ground: Geothermal's Place in the Revolving Energy Market'' by Richard Jaros; ''Recent Developments in Japan's Hot Dry Rock Program'' by Tsutomu Yamaguchi; and ''Options in the Eleventh Year for Interim Standard Offer Number Four Contracts'' by Thomas C. Hinrichs.

  11. 75 FR 44276 - Bureau of Ocean Energy Management, Regulation, and Enforcement (BOEMRE); Cancellation of Oil and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    .... The findings of the National Commission on the BP Deepwater Horizon Oil Spill and Offshore Drilling... Bureau of Ocean Energy Management, Regulation, and Enforcement (BOEMRE); Cancellation of Oil and Gas... Mexico (GOM) AGENCY: Bureau of Ocean Energy Management, Regulation, and Enforcement, Interior....

  12. A Study on Collaborative Operation Methods between New Energy Type Dispersed Power Supply System and SMES by Modified Euler Type Moving Average Prediction Model

    NASA Astrophysics Data System (ADS)

    Monai, Toshiharu; Takano, Ichiro; Nishikawa, Hisao; Sawada, Yoshio

    In this paper, the modified Euler type Moving Average Prediction (EMAP) model is proposed in order to operate a dispersed power supply system using new energy in autonomous mode. Furthermore, EMAP model is applied to operate a new type dispersed power supply system consisting of a large scale photovoltaic system (PV), a fuel cell (FC) as well as a small scale superconducting magnetic energy storage system (SMES). This distributed power supply system can meet the multi-quality electric power requirements of customers, and ensures voltage stability and UPS (Uninterruptible Power Supply) function as well. Each sub-system of this distributed power supply contributes to the above-mentioned system performance with its own excellent characteristics. Moreover, response characteristics of this system are confirmed with simulation by software PSIM, and, under collaborative operation methods by EMAP model, the required capacity of SMES to compensate the fluctuation of both PV output and load demand is examined by the simulation using software MATLAB/Simulink.

  13. Designing Energy Supply Chains with the P-Graph Framework under Cost Constraints andSustainability Considerations

    EPA Science Inventory

    A computer-aided methodology for designing sustainable supply chains is presented using the P-graph framework to develop supply chain structures which are analyzed using cost, the cost of producing electricity, and two sustainability metrics: ecological footprint and emergy. They...

  14. Designing Energy Supply Chains with the P-Graph Framework under Cost Constraints andSustainability Considerations

    EPA Science Inventory

    A computer-aided methodology for designing sustainable supply chains is presented using the P-graph framework to develop supply chain structures which are analyzed using cost, the cost of producing electricity, and two sustainability metrics: ecological footprint and emergy. They...

  15. Regulation of metabolic flux in Lactobacillus casei for lactic acid production by overexpressed ldhL gene with two-stage oxygen supply strategy.

    PubMed

    Ge, Xiang-Yang; Xu, Yan; Chen, Xiang; Zhang, Long-Yun

    2015-01-01

    This study describes a novel strategy to regulate the metabolic flux for lactic acid production in Lactobacillus casei. The ldhL gene encoding L-lactate dehydrogenase (L-LDH) was overexpressed in L. casei, and a two-stage oxygen supply strategy (TOS) that maintained a medium oxygen supply level during the early fermentation phase, and a low oxygen supply level in the later phase was carried out. As a consequence, a maximum L-LDH activity of 95.6 U/ml was obtained in the recombinant strain, which was over 4-fold higher than that of the initial strain. Under the TOS for L. casei (pMG-ldhL), the maximum lactic acid concentration of 159.6 g/l was obtained in 36 h, corresponding to a 62.8% increase. The results presented here provide a novel way to regulate the metabolic flux of L. casei for lactic acid production in different fermentation stages, which is available to enhance organic acid production in other strains.

  16. Discussion of Consumer Perspectives on Regulation of Energy Efficiency Investments

    EPA Pesticide Factsheets

    This report considers consumers’ perspectives on policy and regulatory issues associated with the administration of energy efficiency investments funded by ratepayers of electric and natural gas utilities.

  17. 76 FR 33615 - Energy Priorities and Allocations System Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-09

    ..., unexploded bomb reconnaissance, essential debris clearance, emergency welfare measures, and immediately... coal, coke, coal chemicals, coal liquification, and coal gasification), and atomic energy, and the...

  18. Issues in federal preemption of state appliance energy efficiency regulations

    SciTech Connect

    Fang, J.M.; Balistocky, S.; Schaefler, A.M.

    1982-12-01

    The findings and conclusions of the analysis of the various issues involved in the federal preemption of state regulations for the DOE no standard rule on covered appliances are summarized. The covered products are: refrigerators, refrigerator-freezers, freezers, clothes dryers, kitchen ranges and ovens, water heaters (excluding heat pump water heaters), room air conditioners, central air conditioners (excluding heat pumps), and furnaces. A detailed discussion of the rationale for the positions of groups offering comment for the record is presneted. The pertinent categories of state and local regulations and programs are explained, then detailed analysis is conducted on the covered products and regulations. Issues relating to the timing of preemption of state regulations are discussed, as well as issues relating to burden of proof, contents of petitions for exemptions from preemption, criteria for evaluating petitions, and procedural and other issues. (LEW)

  19. Energy-water nexus analysis of enhanced water supply scenarios: a regional comparison of Tampa Bay, Florida, and San Diego, California.

    PubMed

    Mo, Weiwei; Wang, Ranran; Zimmerman, Julie B

    2014-05-20

    Increased water demand and scarce freshwater resources have forced communities to seek nontraditional water sources. These challenges are exacerbated in coastal communities, where population growth rates and densities in the United States are the highest. To understand the current management dilemma between constrained surface and groundwater sources and potential new water sources, Tampa Bay, Florida (TB), and San Diego, California (SD), were studied through 2030 accounting for changes in population, water demand, and electricity grid mix. These locations were chosen on the basis of their similar populations, land areas, economies, and water consumption characters as well as their coastal locations and rising contradictions between water demand and supply. Three scenarios were evaluated for each study area: (1) maximization of traditional supplies; (2) maximization of seawater desalination; and (3) maximization of nonpotable water reclamation. Three types of impacts were assessed: embodied energy, greenhouse gas (GHG) emission, and energy cost. SD was found to have higher embodied energy and energy cost but lower GHG emission than TB in most of its water infrastructure systems because of the differences between the electricity grid mixes and water resources of the two regions. Maximizing water reclamation was found to be better than increasing either traditional supplies or seawater desalination in both regions in terms of the three impact categories. The results further imply the importance of assessing the energy-water nexus when pursuing demand-side control targets or goals as well to ensure that the potentially most economical options are considered.

  20. Energy status regulates disease development and respiratory metabolism of Lasiodiplodia theobromae (Pat.) Griff. & Maubl.-infected longan fruit.

    PubMed

    Zhang, Shen; Lin, Hetong; Lin, Yifen; Lin, Yixiong; Hung, Yen-Con; Chen, Yihui; Wang, Hui; Shi, John

    2017-09-15

    Lasiodiplodia theobromae (Pat.) Griff. & Maubl. is a major pathogen causing decay of harvested longan fruit. The roles of energy status regulated by 2,4-dinitrophenol (DNP) and adenosine triphosphate (ATP) in disease development regarding respiratory metabolism of L. theobromae-inoculated "Fuyan" longan fruit were studied. Compared with L. theobromae-inoculated longans, DNP treatment could promote the index of fruit disease, accelerate the decrease in energy charge, increase respiration rate and the activities of respiratory terminal oxidases like CCO, AAO and PPO, elevate contents of NAD and NADH, but decrease NAD kinase activity, as well as contents of NADP and NADPH; however, exogenous ATP supply acted contrarily. Above results suggested the different energy status caused by DNP and ATP treatments accelerated or delayed the disease development of L. theobromae-inoculated longans via regulating Embden-Meyerhof pathway (EMP) and tricarboxylic acid (TCA) cycle, pentose phosphate pathway (PPP) and activities of respiratory terminal oxidases. Copyright © 2017 Elsevier Ltd. All rights reserved.