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Sample records for energy-saving hepatoprotective compound

  1. Interactions between Transporters and Herbal Medicines/Drugs: A Focus on Hepatoprotective Compounds.

    PubMed

    Zhang, Aijie; Li, Quansheng; He, Xin; Si, Duanyun; Liu, Changxiao

    2015-01-01

    Many herbal medicines and drugs are available in the clinic as potent hepatoprotective agents for the treatment of commonly occurring liver diseases. Recently, herbal medicines such as silymarin and curcumin have gained more attention and popularity for the treatment of various liver diseases because of their safety and efficacy profiles. Some of them are related to transporters for drug disposition processes, therapeutic efficacy and/or adverse drug reactions. Currently, herbal medicines and diet supplements made from natural products are widely used in patients who are being treated with conventional prescription medicines, which are related to an increasing risk of herbal-drug interactions (HDIs) and/or drug-drug interactions (DDIs). The purpose of present review is to summarize the contemporary knowledge of transporter-mediated HDIs or DDIs for herbal medicines/drugs focusing on hepatoprotective compounds. Several herbal medicines/drugs are discussed in detail in this review.

  2. The use of marine-derived bioactive compounds as potential hepatoprotective agents

    PubMed Central

    Nair, Dileep G; Weiskirchen, Ralf; Al-Musharafi, Salma K

    2015-01-01

    The marine environment may be explored as a rich source for novel drugs. A number of marine-derived compounds have been isolated and identified, and their therapeutic effects and pharmacological profiles are characterized. In the present review, we highlight the recent studies using marine compounds as potential hepatoprotective agents for the treatment of liver fibrotic diseases and discuss the proposed mechanisms of their activities. In addition, we discuss the significance of similar studies in Oman, where the rich marine life provides a potential for the isolation of novel natural, bioactive products that display therapeutic effects on liver diseases. PMID:25500871

  3. Save Energy: Save Money!

    ERIC Educational Resources Information Center

    Eccli, Eugene; And Others

    This publication is a collection of inexpensive energy saving tips and home improvements for home owners, particularly in low-income areas or in older homes. Section titles are: (1) Keeping Warm; (2) Getting Heat Where You Need It; (3) Using the Sun; (4) Furnaces, Stoves, and Fireplaces; (5) Insulation and Other Energy Needs; (6) Do-It-Yourself…

  4. Plugging into Energy Savings.

    ERIC Educational Resources Information Center

    Harrigan, Merrilee

    1999-01-01

    The nonprofit Alliance to Save Energy has been helping schools reduce energy consumption through a combination of retrofits, classroom instruction, and behavior. Lists eight small steps to big energy savings, among them: involve the whole school, stop leaks, turn off computers, and recycle. (MLF)

  5. Remanufacturing and energy savings.

    PubMed

    Gutowski, Timothy G; Sahni, Sahil; Boustani, Avid; Graves, Stephen C

    2011-05-15

    Remanufactured products that can substitute for new products are generally claimed to save energy. These claims are made from studies that look mainly at the differences in materials production and manufacturing. However, when the use phase is included, the situation can change radically. In this Article, 25 case studies for eight different product categories were studied, including: (1) furniture, (2) clothing, (3) computers, (4) electric motors, (5) tires, (6) appliances, (7) engines, and (8) toner cartridges. For most of these products, the use phase energy dominates that for materials production and manufacturing combined. As a result, small changes in use phase efficiency can overwhelm the claimed savings from materials production and manufacturing. These use phase energy changes are primarily due to efficiency improvements in new products, and efficiency degradation in remanufactured products. For those products with no, or an unchanging, use phase energy requirement, remanufacturing can save energy. For the 25 cases, we found that 8 cases clearly saved energy, 6 did not, and 11 were too close to call. In some cases, we could examine how the energy savings potential of remanufacturing has changed over time. Specifically, during times of significant improvements in energy efficiency, remanufacturing would often not save energy. A general design trend seems to be to add power to a previously unpowered product, and then to improve on the energy efficiency of the product over time. These trends tend to undermine the energy savings potential of remanufacturing.

  6. Lighting Control Energy Savings

    SciTech Connect

    LBL,

    1985-01-01

    CONTROLITE 1.0 is a lighting energy analysis program designed to calculate the energy savings and cost benefits obtainable using lighting controls in buildings. The program can compute the lighting energy reductions that result from using daylighting, scheduling, and other control strategies. When modeling daylight control systems, the program uses QUICKLITE to compute the daylight illuminances at specified points 5 times a day, 12 days a year (the 21st of each month), and for two sky conditions (clear and overcast skies). Fourier series techniques are used to fit a continuous curve through the computed illuminance points. The energy use for each of the 12 days is then computed given user-specified power-in/light-out characteristics of the modeled control system. The monthly and annual energy usage for overcast and clear conditions are found separately by fitting two long-term Fourier series curves to the energy use computed for each of the 12 days. Finally, the monthly energy use is calculated by taking a weighted average for the monthly energy use computed for the overcast and clear sky conditions. The program only treats the energy use directly attributable to lighting. The impact of lighting control strategies on building thermal loads is not computed. The program allows input of different control schedules (i.e., on/off times for the lighting system) for each day of the week, but every week of the year is treated the same; thus, holidays cannot be modeled explicitly. When used for daylighting purposes, CONTROLITE1.0 understands only clear and overcast conditions. User-supplied values for the proportion of clear and overcast hours for each month of the year are required to accommodate different climatic conditions.

  7. Lighting Control Energy Savings

    1985-01-01

    CONTROLITE 1.0 is a lighting energy analysis program designed to calculate the energy savings and cost benefits obtainable using lighting controls in buildings. The program can compute the lighting energy reductions that result from using daylighting, scheduling, and other control strategies. When modeling daylight control systems, the program uses QUICKLITE to compute the daylight illuminances at specified points 5 times a day, 12 days a year (the 21st of each month), and for two skymore » conditions (clear and overcast skies). Fourier series techniques are used to fit a continuous curve through the computed illuminance points. The energy use for each of the 12 days is then computed given user-specified power-in/light-out characteristics of the modeled control system. The monthly and annual energy usage for overcast and clear conditions are found separately by fitting two long-term Fourier series curves to the energy use computed for each of the 12 days. Finally, the monthly energy use is calculated by taking a weighted average for the monthly energy use computed for the overcast and clear sky conditions. The program only treats the energy use directly attributable to lighting. The impact of lighting control strategies on building thermal loads is not computed. The program allows input of different control schedules (i.e., on/off times for the lighting system) for each day of the week, but every week of the year is treated the same; thus, holidays cannot be modeled explicitly. When used for daylighting purposes, CONTROLITE1.0 understands only clear and overcast conditions. User-supplied values for the proportion of clear and overcast hours for each month of the year are required to accommodate different climatic conditions.« less

  8. Effect of Brewing Duration on the Antioxidant and Hepatoprotective Abilities of Tea Phenolic and Alkaloid Compounds in a t-BHP Oxidative Stress-Induced Rat Hepatocyte Model.

    PubMed

    Braud, Laura; Peyre, Ludovic; de Sousa, Georges; Armand, Martine; Rahmani, Roger; Maixent, Jean-Michel

    2015-01-01

    Tea is an interesting source of antioxidants capable of counteracting the oxidative stress implicated in liver diseases. We investigated the impact of antioxidant molecules provided by a mixture of teas' leaves (green, oolong, pu-erh) after different infusion durations in the prevention of oxidative stress in isolated rat hepatocytes, by comparison with pure epigallocatechin-3-gallate (EGCG), the main representative of tea catechins. Dried aqueous tea extracts (ATE) obtained after 5, 15 and 30 min infusion time were characterized for total polyphenols (gallic acid equivalent), catechins, gallic acid and caffeine (HPLC-DAD/ESI-MS) contents, and for scavenging ability against 2,2-diphenyl-1-picrylhydrazyl free radical. Hepatoprotection was evaluated through hepatocyte viability tests using tert-butyl hydroperoxide as a stress inducer, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, neutral red uptake, real-time cellular impedance) and mitochondrial function tests. We showed that a 5-min incubation time is sufficient for an optimal bioaccessibility of tea compounds with the highest antioxidative ability, which decreases for longer durations. A 4-h pretreatment of cells with ATE significantly prevented cell death by regulating reactive oxygen species production and maintaining mitochondrial integrity. Pure EGCG, at doses similar in ATE (5-12 µM), was inefficient, suggesting a plausible synergy of several water-soluble tea compounds to explain the ATE beneficial effects. PMID:26287152

  9. Effect of Brewing Duration on the Antioxidant and Hepatoprotective Abilities of Tea Phenolic and Alkaloid Compounds in a t-BHP Oxidative Stress-Induced Rat Hepatocyte Model.

    PubMed

    Braud, Laura; Peyre, Ludovic; de Sousa, Georges; Armand, Martine; Rahmani, Roger; Maixent, Jean-Michel

    2015-08-17

    Tea is an interesting source of antioxidants capable of counteracting the oxidative stress implicated in liver diseases. We investigated the impact of antioxidant molecules provided by a mixture of teas' leaves (green, oolong, pu-erh) after different infusion durations in the prevention of oxidative stress in isolated rat hepatocytes, by comparison with pure epigallocatechin-3-gallate (EGCG), the main representative of tea catechins. Dried aqueous tea extracts (ATE) obtained after 5, 15 and 30 min infusion time were characterized for total polyphenols (gallic acid equivalent), catechins, gallic acid and caffeine (HPLC-DAD/ESI-MS) contents, and for scavenging ability against 2,2-diphenyl-1-picrylhydrazyl free radical. Hepatoprotection was evaluated through hepatocyte viability tests using tert-butyl hydroperoxide as a stress inducer, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, neutral red uptake, real-time cellular impedance) and mitochondrial function tests. We showed that a 5-min incubation time is sufficient for an optimal bioaccessibility of tea compounds with the highest antioxidative ability, which decreases for longer durations. A 4-h pretreatment of cells with ATE significantly prevented cell death by regulating reactive oxygen species production and maintaining mitochondrial integrity. Pure EGCG, at doses similar in ATE (5-12 µM), was inefficient, suggesting a plausible synergy of several water-soluble tea compounds to explain the ATE beneficial effects.

  10. Moonlight project promotes energy-saving technology

    NASA Astrophysics Data System (ADS)

    Ishihara, A.

    1986-01-01

    In promoting energy saving, development of energy conservation technologies aimed at raising energy efficiency in the fields of energy conversion, its transportation, its storage, and its consumption is considered, along with enactment of legal actions urging rational use of energies and implementation of an enlightenment campaign for energy conservation to play a crucial role. Under the Moonlight Project, technical development is at present being centered around the following six pillars: (1) large scale energy saving technology; (2) pioneering and fundamental energy saving technology; (3) international cooperative research project; (4) research and survey of energy saving technology; (5) energy saving technology development by private industry; and (6) promotion of energy saving through standardization. Heat pumps, magnetohydrodynamic generators and fuel cells are discussed.

  11. The hepatoprotection of caffeic acid and rosmarinic acid, major compounds of Perilla frutescens, against t-BHP-induced oxidative liver damage.

    PubMed

    Yang, Sung-Yong; Hong, Chung-Oui; Lee, Gung Pyo; Kim, Cheong-Tae; Lee, Kwang-Won

    2013-05-01

    Perilla frutescens leaves are often used in East Asian gourmet food. In this study, we investigated the hepatoprotective effects of caffeic acid (CA), rosmarinic acid (RA), and their combination. P. frutescens contains 1.32μg CA/mg dry material (DM) and 26.84μg RA/mg DM analyzed by HPLC-DAD and HPLC-MS. CA remarkably reduced the oxidative damage than rosmarinic acid in an in vitro study. Oral intubation with CA or RA alone for five days was conducted prior to treatment with a single dose of tert-butyl hydroperoxide (0.5mmol/kg b.w., i.p.), which led to a significant reduction of indicators of hepatic toxicity, such as aspartate aminotransferase, alanine aminotransferase, oxidized glutathione, lipid peroxidation and enzyme activities related to antioxidant such as catalase, glutathione peroxidase and superoxide dismutase. Interestingly, compared to treatment with CA or RA alone, a combination of both compounds more increased the endogenous antioxidant enzymes and glutathione (GSH) and decreased lipid peroxidation in livers. These results suggest that CA from perilla leaves plays a role in the increased hepatic GSH concentration, and shows an additive hepatic protection with RA against oxidative hepatic damage.

  12. Energy savings in Polish buildings

    SciTech Connect

    Markel, L.C.; Gula, A.; Reeves, G.

    1995-12-31

    A demonstration of low-cost insulation and weatherization techniques was a part of phase 1 of the Krakow Clean Fossil Fuels and Energy Efficient Project. The objectives were to identify a cost-effective set of measures to reduce energy used for space heating, determine how much energy could be saved, and foster widespread implementation of those measures. The demonstration project focused on 4 11-story buildings in a Krakow housing cooperative. Energy savings of over 20% were obtained. Most important, the procedures and materials implemented in the demonstration project have been adapted to Polish conditions and applied to other housing cooperatives, schools, and hospitals. Additional projects are being planned, in Krakow and other cities, under the direction of FEWE-Krakow, the Polish Energie Cities Network, and Biuro Rozwoju Krakowa.

  13. Potential Water and Energy Savings from Showerheads

    SciTech Connect

    Biermayer, Peter J.

    2005-09-28

    This paper estimates the benefits and costs of six water reduction scenarios. Benefits and costs of showerhead scenarios are ranked in this paper by an estimated water reduction percentage. To prioritize potential water and energy saving scenarios regarding showerheads, six scenarios were analyzed for their potential water and energy savings and the associated dollar savings to the consumer.

  14. Energy Savings Measure Packages: Existing Homes

    SciTech Connect

    Casey, S.; Booten, C.

    2011-11-01

    This document presents the most cost effective Energy Savings Measure Packages (ESMP) for existing mixed-fuel and all electric homes to achieve 15% and 30% savings for each BetterBuildings grantee location across the US. These packages are optimized for minimum cost to homeowners for given source energy savings given the local climate and prevalent building characteristics (i.e. foundation types). Maximum cost savings are typically found between 30% and 50% energy savings over the reference home. The dollar value of the maximum annual savings varies significantly by location but typically amounts to $300 - $700/year.

  15. Energy Savings Measure Packages. Existing Homes

    SciTech Connect

    Casey, Sean; Booten, Chuck

    2011-11-01

    This document presents the most cost effective Energy Savings Measure Packages (ESMP) for existing mixed-fuel and all electric homes to achieve 15% and 30% savings for each BetterBuildings grantee location across the United States. These packages are optimized for minimum cost to homeowners for source energy savings given the local climate and prevalent building characteristics (i.e. foundation types). Maximum cost savings are typically found between 30% and 50% energy savings over the reference home; this typically amounts to $300 - $700/year.

  16. Hepatoprotective effect of silymarin

    PubMed Central

    Vargas-Mendoza, Nancy; Madrigal-Santillán, Eduardo; Morales-González, Ángel; Esquivel-Soto, Jaime; Esquivel-Chirino, Cesar; García-Luna y González-Rubio, Manuel; Gayosso-de-Lucio, Juan A; Morales-González, José A

    2014-01-01

    The use of medicinal plants in treating illnesses has been reported since ancestral times. In the case of hepatic diseases, several species such as Silybum marianum, Phyllanthus niruri, and Panus giganteus (Berk.) have been shown to ameliorate hepatic lesions. Silymarin is a natural compound derived from the species Silybum marianum, which is commonly known as Milk thistle. This plant contains at least seven flavoligands and the flavonoid taxifolin. The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free radicals that are produced from the metabolism of toxic substances such as ethanol, acetaminophen, and carbon tetrachloride. The generation of free radicals is known to damage cellular membranes and cause lipoperoxidation. Silymarin enhances hepatic glutathione and may contribute to the antioxidant defense of the liver. It has also been shown that silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity. A previous study on humans reported that silymarin treatment caused a slight increase in the survival of patients with cirrhotic alcoholism compared with untreated controls. PMID:24672644

  17. Energy Savings Performance Contract Success Stories

    SciTech Connect

    2009-07-27

    Three case study success stories showcasing energy savings performance contract projects at Dyess Air Force Base, Food and Drug Administration White Oaks Campus, and the Harold Washington Social Security Administration Center.

  18. Terpenoids from Juniperus procera with hepatoprotective activity.

    PubMed

    Alqasoumi, Saleh Ibrahim; Abdel-Kader, Maged Saad

    2012-04-01

    The petroleum ether fraction of Juniperus procera showed significant activity as hepatoprotective when investigated against carbon tetrachloride induced liver injury. The hepatoprotective activity was evaluated through the quantification of biochemical parameters and confirmed using histopathology analysis. Phytochemical investigation of the petroleum ether fraction utilizing different chromatographic techniques resulted in the isolation of six known diterpenoids namely: 4-epi-abietol (1), ferruginol (2), hinokiol (3), sugiol (4), Z-communic acid (5) and hinokiol-1-one 3β,12-dihydroxyabieta-8,11,13-triene-1-one) (6), in addition to the sesquiterpene 8α-acetoxyelemol (7). Both physical and spectral data were used for structure determination and all isolates were evaluated for their hepatoprotective activity. Compounds 1 and 4 were the most effective in reducing the elevated liver enzymes as indication for liver protection.

  19. Silybum marianum: Beyond Hepatoprotection.

    PubMed

    Bahmani, Mahmood; Shirzad, Hedayatollah; Rafieian, Samira; Rafieian-Kopaei, Mahmoud

    2015-10-01

    Silybum marianum is a medicinal plant that has long been used as hepatoprotective remedy. It has been used for the treatment of numerous liver disorders characterized by functional impairment or degenerative necrosis. Its hepatoprotective activity is unique and acts in different ways, including antioxidant and anti-inflammatory activities, cell permeability regulator and membrane stabilizer, stimulation of liver regeneration and inhibition of deposition in collagen fibers, which may lead to cirrhosis. Most of documented data with Silybum marianum are about liver disorders; however, recently several beneficial properties on a wide variety of other disorders such as renal protection, hypolipidemic and anti-atherosclerosis activities, cardiovascular protection, prevention of insulin resistance, especially in cirrhotic patients, cancer, and Alzheimer prevention. It is also used as a food remedy. This review article aims to present different aspects of Silybum marianum, especially the data in recently published articles about its effects on different diseases, apart from presenting the aspects of its hepatoprotection.

  20. Risk transfer via energy savings insurance

    SciTech Connect

    Mills, Evan

    2001-10-01

    Among the key barriers to investment in energy efficiency improvements are uncertainties about attaining projected energy savings and apprehension about potential disputes over these savings. The fields of energy management and risk management are thus intertwined. While many technical methods have emerged to manage performance risks (e.g. building commissioning), financial risk transfer techniques are less developed in the energy management arena than in other more mature segments of the economy. Energy Savings Insurance (ESI) - formal insurance of predicted energy savings - is one method of transferring financial risks away from the facility owner or energy services contractor. ESI offers a number of significant advantages over other forms of financial risk transfer, e.g. savings guarantees or performance bonds. ESI providers manage risk via pre-construction design review as well as post-construction commissioning and measurement and verification of savings. We found that the two mos t common criticisms of ESI - excessive pricing and onerous exclusions - are not born out in practice. In fact, if properly applied, ESI can potentially reduce the net cost of energy savings projects by reducing the interest rates charged by lenders, and by increasing the level of savings through quality control. Debt service can also be ensured by matching loan payments to projected energy savings while designing the insurance mechanism so that payments are made by the insurer in the event of a savings shortfall. We estimate the U.S. ESI market potential of $875 million/year in premium income. From an energy-policy perspective, ESI offers a number of potential benefits: ESI transfers performance risk from the balance sheet of the entity implementing the energy savings project, thereby freeing up capital otherwise needed to ''self-insure'' the savings. ESI reduces barriers to market entry of smaller energy services firms who do not have sufficiently strong balance sheets to self

  1. 78 FR 20097 - Energy Savings Performance Contracts

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-03

    ... ESPCs at 10 CFR part 436, Subpart B. (See, 60 FR 18334.) To facilitate and accelerate the use of ESPCs... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy Energy Savings Performance Contracts AGENCY: Office...

  2. Remodeling kitchens: A smorgasbord of energy savings

    SciTech Connect

    Sullivan, B.

    1995-09-01

    The kitchen is often the busiest room in the house and is most likely to remodeled repeatedly over the life of a house. The kitchen also represents a concentration of household energy use. Remodeling a kitchen can mean introducing a host of new energy-saving features or making major energy blunders. This article discusses ways to utilized the best features: layout and design; appliances; lighting; windows and skylights; ventilation; insulation and air sealing; water; household recycling; green building materials.

  3. Weekend home energy-saving projects

    SciTech Connect

    Jones, P.

    1984-01-01

    There are guidelines in this book for numerous inexpensive, minimally time-consuming energy-saving projects that can reduce the amount of energy used in a household and the size of the monthly utility bill. Five chapters on insulation, weatherstripping, plumbing improvements, solar heating, and ways to reduce electricity bills provide specific projects that require little or no prior experience. The final chapter offers suggestions and tips for buying and installing a wood-burning stove. 52 figures.

  4. Energy Savings Potential of Radiative Cooling Technologies

    SciTech Connect

    Fernandez, Nicholas; Wang, Weimin; Alvine, Kyle J.; Katipamula, Srinivas

    2015-11-30

    Pacific Northwest National Laboratory (PNNL), with funding from the U.S. Department of Energy’s (DOE’s) Building Technologies Program (BTP), conducted a study to estimate, through simulation, the potential cooling energy savings that could be achieved through novel approaches to capturing free radiative cooling in buildings, particularly photonic ‘selective emittance’ materials. This report documents the results of that study.

  5. Economic Energy Savings Potential in Federal Buildings

    SciTech Connect

    Brown, Daryl R.; Dirks, James A.; Hunt, Diane M.

    2000-09-04

    The primary objective of this study was to estimate the current life-cycle cost-effective (i.e., economic) energy savings potential in Federal buildings and the corresponding capital investment required to achieve these savings, with Federal financing. Estimates were developed for major categories of energy efficiency measures such as building envelope, heating system, cooling system, and lighting. The analysis was based on conditions (building stock and characteristics, retrofit technologies, interest rates, energy prices, etc.) existing in the late 1990s. The potential impact of changes to any of these factors in the future was not considered.

  6. Energy Savings Performance Contract (ESPC) ENABLE Program

    SciTech Connect

    2012-06-01

    The Energy Savings Performance Contract (ESPC) ENABLE program, a new project funding approach, allows small Federal facilities to realize energy and water savings in six months or less. ESPC ENABLE provides a standardized and streamlined process to install targeted energy conservation measures (ECMs) such as lighting, water, and controls with measurement and verification (M&V) appropriate for the size and scope of the project. This allows Federal facilities smaller than 200,000 square feet to make progress towards important energy efficiency and water conservation requirements.

  7. Cool energy savings opportunities in commercial refrigeration

    SciTech Connect

    Westphalen, D.; Brodrick, J.; Zogg, R.

    1998-07-01

    The commercial sector consumes over 13 quads of primary energy annually. Most of this consumption (two-thirds) meets the energy needs of lighting and heating, ventilation, and air-conditioning. The largest consuming group of the remaining one-third is commercial refrigeration at about one quad annually (990 trillion Btu), valued at over $7 billion per year to the commercial sector consumer. Potential energy savings are estimated to be about 266 trillion Btu, with consumer savings valued at about $2 billion. This study provides the first known estimates of these values using a bottom-up approach. The authors evaluated numerous self-contained and engineered commercial refrigeration systems in this study, such as: supermarket central systems, beverage merchandisers, ice machines, and vending machines. Typical physical characteristics of each equipment type were identified at the component level for energy consumption. This information was used to form a detailed database from which they arrived at the estimate of 990 trillion Btu energy consumption for the major equipment types used in commercial refrigeration. Based on the implementation of the most cost-effective technology improvements for the seven major equipment types, they estimated an annual potential energy savings of 266 trillion Btu. Much of the savings can be realized with the implementation of high-efficiency fan motors and compressors. In many cases, payback can be realized within three years.

  8. Chinese hotel general managers' perspectives on energy-saving practices

    NASA Astrophysics Data System (ADS)

    Zhu, Yidan

    As hotels' concern about sustainability and budget-control is growing steadily, energy-saving issues have become one of the important management concerns hospitality industry face. By executing proper energy-saving practices, previous scholars believed that hotel operation costs can decrease dramatically. Moreover, they believed that conducting energy-saving practices may eventually help the hotel to gain other benefits such as an improved reputation and stronger competitive advantage. The energy-saving issue also has become a critical management problem for the hotel industry in China. Previous research has not investigated energy-saving in China's hotel segment. To achieve a better understanding of the importance of energy-saving, this document attempts to present some insights into China's energy-saving practices in the tourist accommodations sector. Results of the study show the Chinese general managers' attitudes toward energy-saving issues and the differences among the diverse hotel managers who responded to the study. Study results indicate that in China, most of the hotels' energy bills decrease due to the implementation of energy-saving equipments. General managers of hotels in operation for a shorter period of time are typically responsible for making decisions about energy-saving issues; older hotels are used to choosing corporate level concerning to this issue. Larger Chinese hotels generally have official energy-saving usage training sessions for employees, but smaller Chinese hotels sometimes overlook the importance of employee training. The study also found that for the Chinese hospitality industry, energy-saving practices related to electricity are the most efficient and common way to save energy, but older hotels also should pay attention to other ways of saving energy such as water conservation or heating/cooling system.

  9. Energy Savings Potential and Research & Development Opportunities for Commercial Refrigeration

    SciTech Connect

    none,

    2009-09-01

    This study documents the energy consumption of commercial refrigeration equipment (CRE) in the U.S. and evaluated the energy savings potential of various technologies and energy efficiency measures that could be applied to such equipment. The study provided an overview of CRE applications, assessed the energy-savings potential of CRE in the U.S., outline key barriers to adoption of energy-savings technologies, and recommended opportunities for advanced energy saving technology research. The study was modeled after an earlier 1996 report by Arthur D. Little, Inc., and updated key information, examined more equipment types, and outlined long-term research and development opportunities.

  10. Hepatoprotective glycosides from Leonurus japonicus Houtt.

    PubMed

    Li, Yixiu; Chen, Zhong; Feng, Ziming; Yang, Yanan; Jiang, Jianshuang; Zhang, Peicheng

    2012-02-01

    Two new phenylethanoid glycosides 1 and 2 named leonoside E and leonoside F, and one new sesquiterpene glycoside (3) identified as 7α (H)-eudesmane-4,11 (12)-diene-3-one-2β-hydroxy-13-β-d-glucopyranoside, together with seven known glycosides (4-10), were isolated from the aerial part of Leonurus japonicus Houtt. Their structures were elucidated on the basis of spectroscopic data and chemical evidence. When tested in in vitro assays, compounds 1, 2, 4, and 6 exhibited potent hepatoprotective activity against d-galactosamine-induced toxicity in HL-7702 cells at concentration of 1×10(-5) M.

  11. Study of the hepatoprotective effect of Juniperus phoenicea constituents.

    PubMed

    Alqasoumi, Saleh Ibrahim; Farraj, Abdallah Ibrahim; Abdel-Kader, Maged Saad

    2013-09-01

    Different fraction obtained from the aerial parts of Juniperus phoenicea showed significant activity as hepatoprotective when investigated against carbon tetrachloride induced liver injury. The hepatoprotective activity was evaluated through the quantification of biochemical parameters and confirmed using histopathology study. Phytochemical investigation of the petroleum ether, chloroform and methanol fractions utilizing different chromatographic techniques resulted in the isolation of five known diterpenoids namely: 13-epicupressic acid (1), imbricatolic acid (2), 7α-hydroxysandaracopimaric acid (3), 3β-hydroxysandaracopimaric acid (4), isopimaric acid (5), four flavonoid derivatives: cupressuflavone (6), hinokiflavone (7), hypolaetin-7-O-β-xylopyranoside (9), (-) catechin (10), inaddition to sucrose (8). Both physical and spectral data were used for structure determination and all isolates were evaluated for their hepatoprotective activity. Compounds 2 and 6 were effective, however; 7 was the most active. Hepatoprotective activity of 7 is comparable with the standard drug silymarin in reducing the elevated liver enzymes and restoring normal appearance of hepatocytes. Hepatoprotective effect of combination of 6, 7 and silymarin with the diterpene sugiol was also explored.

  12. Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/d-galactosamine-induced liver injury.

    PubMed

    Morita, Tatsuya; Jinno, Keiko; Kawagishi, Hirokazu; Arimoto, Yasushi; Suganuma, Hiroyuki; Inakuma, Takahiro; Sugiyama, Kimio

    2003-03-12

    To evaluate the hepatoprotective activity of spices, 21 different spices were fed to rats with liver damage caused by lipopolysaccharide (LPS) plus d-galactosamine (D-GalN). As assessed by plasma aminotranferase activities, nutmeg showed the most potent hepatoprotective activity. Bioassay-guided isolation of the active compound from nutmeg was carried out in mice by a single oral administration of the respective fractions. Myristicin, one of the major essential oils of nutmeg, was found to possess extraordinarily potent hepatoprotective activity. Myristicin markedly suppressed LPS/D-GalN-induced enhancement of serum TNF-alpha concentrations and hepatic DNA fragmentation in mice. These findings suggest that the hepatoprotective activity of myristicin might be, at least in part, due to the inhibition of TNF-alpha release from macrophages. However, further studies are needed to elucidate the hepatoprotective mechanism(s) of myristicin.

  13. Energy Savings by Treating Buildings as Systems

    NASA Astrophysics Data System (ADS)

    Harvey, L. D. Danny

    2008-09-01

    This paper reviews the opportunities for dramatically reducing energy use in buildings by treating buildings as systems, rather than focusing on device efficiencies. Systems-level considerations are relevant for the operation of heat pumps (where the temperatures at which heat or coldness are distributed are particularly important); the joint or separate provision of heating, cooling, and ventilation; the joint or separate removal of sensible heat and moisture; and in the operation of fluid systems having pumps. Passive heating, cooling, and ventilation, as well as daylighting (use of sunlight for lighting purposes) also require consideration of buildings as systems. In order to achieve the significant (50-75%) energy savings that are possible through a systems approach, the design process itself has to involve a high degree of integration between the architect and various engineering disciplines (structural, mechanical, electrical), and requires the systematic examination and adjustment of alternative designs using computer simulation models.

  14. The Economics of Energy Savings Performance Contracts

    SciTech Connect

    Shonder, John A

    2010-01-01

    Energy Savings Performance Contracts (ESPCs) allow governments to tap private capital to finance energy efficiency improvements; the debt service on the financing is paid from the energy and energy-related cost savings generated by the efficiency projects themselves. Since 1998 about 43% of the funding for energy efficiency upgrades in US federal buildings has come from ESPC and other similar programs. This paper describes the balance sheet for an ESPC project as currently implemented by US federal agencies, and shows how parameters such as the cost of the project, the interest rate for financing, level of savings, energy escalation rates, and others combine to determine the project cash flow. The paper also examines the sensitivity of project economics to changes in each of these parameters.

  15. 48 CFR 23.205 - Energy-savings performance contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water Efficiency and Renewable Energy 23.205 Energy-savings... Conservation Policy Act (42 U.S.C. 8287) to use an energy-savings performance contract (ESPC), when...

  16. 48 CFR 23.205 - Energy-savings performance contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND DRUG-FREE WORKPLACE Energy and Water Efficiency and Renewable Energy 23.205 Energy-savings... Conservation Policy Act (42 U.S.C. 8287) to use an energy-savings performance contract (ESPC), when...

  17. Hepatoprotective triterpenes from the gum resin of Boswellia carterii.

    PubMed

    Wang, Yan-Gai; Ma, Qin-Ge; Tian, Jin; Ren, Jin; Wang, Ai-Guo; Ji, Teng-Fei; Yang, Jian-Bo; Su, Ya-Lun

    2016-03-01

    Ten tirucallane-type triterpenes named boscartene A-J and a nor-tetracyclic triterpene boscartene K, together with ten known compounds were isolated from the gum resin of Boswellia carterii Birdw. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis. In vitro assay, some of these compounds (10 μM) showed moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell damage.

  18. Hepatoprotective triterpenes from the gum resin of Boswellia carterii.

    PubMed

    Wang, Yan-Gai; Ma, Qin-Ge; Tian, Jin; Ren, Jin; Wang, Ai-Guo; Ji, Teng-Fei; Yang, Jian-Bo; Su, Ya-Lun

    2016-03-01

    Ten tirucallane-type triterpenes named boscartene A-J and a nor-tetracyclic triterpene boscartene K, together with ten known compounds were isolated from the gum resin of Boswellia carterii Birdw. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis. In vitro assay, some of these compounds (10 μM) showed moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell damage. PMID:26739386

  19. Hepatoprotective phenylethanoid glycosides from Cirsium setosum.

    PubMed

    Ma, Qinge; Guo, Yongming; Luo, Baomin; Liu, Wenmin; Wei, Rongrui; Yang, Chunxia; Ding, Chenghua; Xu, Xuefeng; He, Minghui

    2016-08-01

    Two new phenylethanoid glycosides, namely β-D-glucopyranoside, 1″-O-(7S)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-α-L-rhamnopyranosyl-4″-[(8E)-7-(3-methoxyl-4-hydroxyphenyl)-8-propenoate] (1) and β-D-glucopyranoside, 1″-O-(7S)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-α-L-rhamnopyranosyl-4″-[(8E)-7-(4-hydroxyphenyl)-8-propenoate] (2), together with six phenylethanoid glycosides were isolated from Cirsium setosum. Their structures were elucidated by their spectroscopic data and references. Compounds 2, 4, 5, 7 and 8 (10 μM) exhibited moderate hepatoprotective activities. Compounds (3-8) were obtained from this plant for the first time.

  20. Demonstration of energy savings of cool roofs

    SciTech Connect

    Konopacki, S.; Gartland, L.; Akbari, H.; Rainer, L.

    1998-06-01

    Dark roofs raise the summertime air-conditioning demand of buildings. For highly-absorptive roofs, the difference between the surface and ambient air temperatures can be as high as 90 F, while for highly-reflective roofs with similar insulative properties, the difference is only about 20 F. For this reason, cool roofs are effective in reducing cooling energy use. Several experiments on individual residential buildings in California and Florida show that coating roofs white reduces summertime average daily air-conditioning electricity use from 2--63%. This demonstration project was carried out to address some of the practical issues regarding the implementation of reflective roofs in a few commercial buildings. The authors monitored air-conditioning electricity use, roof surface temperature, plenum, indoor, and outdoor air temperatures, and other environmental variables in three buildings in California: two medical office buildings in Gilroy and Davis and a retail store in San Jose. Coating the roofs of these buildings with a reflective coating increased the roof albedo from an average of 0.20--0.60. The roof surface temperature on hot sunny summer afternoons fell from 175 F--120 F after the coating was applied. Summertime average daily air-conditioning electricity use was reduced by 18% (6.3 kWh/1000ft{sup 2}) in the Davis building, 13% (3.6 kWh/1000ft{sup 2}) in the Gilroy building, and 2% (0.4 kWh/1000ft{sup 2}) in the San Jose store. In each building, a kiosk was installed to display information from the project in order to educate and inform the general public about the environmental and energy-saving benefits of cool roofs. They were designed to explain cool-roof coating theory and to display real-time measurements of weather conditions, roof surface temperature, and air-conditioning electricity use. 55 figs., 15 tabs.

  1. Hepatoprotective Limonoids from Andiroba (Carapa guianensis).

    PubMed

    Ninomiya, Kiyofumi; Miyazawa, Seiya; Ozeki, Kaiten; Matsuo, Natsuko; Muraoka, Osamu; Kikuchi, Takashi; Yamada, Takeshi; Tanaka, Reiko; Morikawa, Toshio

    2016-01-01

    Three gedunin-type limonoids, gedunin (1), 6α-acetoxygedunin (2), and 7-deacetoxy-7-oxogedunin (3), which were isolated from the seed and flower oils of andiroba (Carapa guianensis Aublet, Meliaceae), exhibited hepatoprotective effects at doses of 25 mg/kg, p.o. against d-galactosamine (d-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. To characterize the mechanisms of action of 1-3 and clarify the structural requirements for their hepatoprotective effects, 17 related limonoids (1-17) isolated from the seed and/or flower oils of C. guianensis were examined in in vitro studies assessing their effects on (i) d-GalN-induced cytotoxicity in primary cultured mouse hepatocytes, (ii) LPS-induced nitric oxide (NO) production in mouse peritoneal macrophages, and (iii) tumor necrosis factor-α (TNF-α)-induced cytotoxicity in L929 cells. The mechanisms of action of 1-3 are likely to involve the inhibition of LPS-induced macrophage activation and reduced sensitivity of hepatocytes to TNF-α; however, these compounds did not decrease the cytotoxicity caused by d-GalN. In addition, the structural requirements of limonoids (1-17) for inhibition of LPS-induced NO production in mouse peritoneal macrophages and TNF-α-induced cytotoxicity in L929 cells were evaluated. PMID:27104518

  2. Hepatoprotective Limonoids from Andiroba (Carapa guianensis)

    PubMed Central

    Ninomiya, Kiyofumi; Miyazawa, Seiya; Ozeki, Kaiten; Matsuo, Natsuko; Muraoka, Osamu; Kikuchi, Takashi; Yamada, Takeshi; Tanaka, Reiko; Morikawa, Toshio

    2016-01-01

    Three gedunin-type limonoids, gedunin (1), 6α-acetoxygedunin (2), and 7-deacetoxy-7-oxogedunin (3), which were isolated from the seed and flower oils of andiroba (Carapa guianensis Aublet, Meliaceae), exhibited hepatoprotective effects at doses of 25 mg/kg, p.o. against d-galactosamine (d-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. To characterize the mechanisms of action of 1–3 and clarify the structural requirements for their hepatoprotective effects, 17 related limonoids (1–17) isolated from the seed and/or flower oils of C. guianensis were examined in in vitro studies assessing their effects on (i) d-GalN-induced cytotoxicity in primary cultured mouse hepatocytes, (ii) LPS-induced nitric oxide (NO) production in mouse peritoneal macrophages, and (iii) tumor necrosis factor-α (TNF-α)-induced cytotoxicity in L929 cells. The mechanisms of action of 1–3 are likely to involve the inhibition of LPS-induced macrophage activation and reduced sensitivity of hepatocytes to TNF-α; however, these compounds did not decrease the cytotoxicity caused by d-GalN. In addition, the structural requirements of limonoids (1–17) for inhibition of LPS-induced NO production in mouse peritoneal macrophages and TNF-α-induced cytotoxicity in L929 cells were evaluated. PMID:27104518

  3. General Merchandise 50% Energy Savings Technical Support Document

    SciTech Connect

    Hale, E.; Leach, M.; Hirsch, A.; Torcellini, P.

    2009-09-01

    This report documents technical analysis for medium-box general merchandise stores aimed at providing design guidance that achieves whole-building energy savings of at least 50% over ASHRAE Standard 90.1-2004.

  4. Breakthrough Energy Savings with Waterjet Technology

    SciTech Connect

    Lee W. Saperstein; R. Larry Grayson; David A. Summers; Jorge Garcia-Joo; Greg Sutton; Mike Woodward; T.P. McNulty

    2007-05-15

    Experiments performed at the University of Missouri-Rolla's Waterjet Laboratory have demonstrated clearly the ability of waterjets to disaggregate, in a single step, four different mineral ores, including ores containing iron, lead and copper products. The study focused mainly on galena-bearing dolomite, a lead ore, and compared the new technology with that of traditional mining and milling to liberate the valuable constituent for the more voluminous host rock. The technical term for the disintegration of the ore to achieve this liberation is comminution. The potential for energy savings if this process can be improved, is immense. Further, if this separation can be made at the mining face, then the potential energy savings include avoidance of transportation (haulage and hoisting) costs to move, process and store this waste at the surface. The waste can, instead, be disposed into the available cavities within the mine. The savings also include the elimination of the comminution, crushing and grinding, stages in the processing plant. Future prototype developments are intended to determine if high-pressure waterjet mining and processing can be optimized to become cheaper than traditional fragmentation by drilling and blasting and to optimize the separation process. The basic new mining process was illustrated in tests on two local rock types, a low-strength sandstone with hematite inclusions, and a medium to high-strength dolomite commonly used for construction materials. Illustrative testing of liberation of minerals, utilized a lead-bearing dolomite, and included a parametric study of the optimal conditions needed to create a size distribution considered best for separation. The target goal was to have 50 percent of the mined material finer than 100 mesh (149 microns). Of the 21 tests that were run, five clearly achieved the target. The samples were obtained as run-of-mine lumps of ore, which exhibited a great deal of heterogeneity within the samples. This, in

  5. Hepatoprotective and antioxidant activity of standardized herbal extracts

    PubMed Central

    Hiraganahalli, Bhaskarmurthy Deepak; Chinampudur, Velusami Chandrasekaran; Dethe, Shekhar; Mundkinajeddu, Deepak; Pandre, Manoj Kumar; Balachandran, Jaya; Agarwal, Amit

    2012-01-01

    Background: Phyllanthus emblica, Camellia sinensis, Mangifera indica, Punica granatum, and Acacia catechu have been shown to possess widespread pharmacological application against multitude of diseases namely cancer, diabetes, liver disorders, and oxidative stress. Objective: We evaluated the hepatoprotective activity of the standardized herbal extracts against tert-butyl hydroperoxide (t-BH) induced toxicity and their mechanism of hepatoprotective action in human hepatocarcinoma cells (HepG2 cell line). Materials and Methods: The hepatoprotective activity was studied by observing the effect of these herbal extracts on t-BH induced reduction in cell viability of HepG2 cells. In addition, the reducing power of the extracts and their ability to scavenge free radicals were evaluated using two antioxidant assay systems: cell free [oxygen radical absorbance capacity (ORAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and [2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonicacid)] (ABTS)] and cell based [cellular antioxidant activity (CAA)]. Results and Discussion: The results obtained showed that these extracts possess significant hepatoprotective activity. This may indicate that the plant extracts contain compounds, which can remove toxic metabolites following t-BH induced toxicity. The extracts exhibited significant antioxidant property as evident by the Trolox values and effective scavenging of DPPH and ABTS radicals. The extracts also demonstrated inhibition of AAPH-induced fluorescence in HepG2 cells. These results indicate the ability of the plant extracts to protect the liver cells from chemical-induced damage, which might be correlated to their radical scavenging potential. Conclusion: This study demonstrates that these extracts have potential hepatoprotective activity which is mainly attributed to the antioxidant potential, which might occur by reduction of lipid peroxidation and cellular damage. PMID:22701284

  6. Technical Support Document: 50% Energy Savings for Small Office Buildings

    SciTech Connect

    Thornton, Brian A.; Wang, Weimin; Huang, Yunzhi; Lane, Michael D.; Liu, Bing

    2010-04-30

    The Technical Support Document (TSD) for 50% energy savings in small office buildings documents the analysis and results for a recommended package of energy efficiency measures (EEMs) referred to as the advanced EEMs. These are changes to a building design that will reduce energy usage. The package of advanced EEMs achieves a minimum of 50% energy savings and a construction area weighted average energy savings of 56.6% over the ANSI/ASHRAE/IESNA Standard 90.1-2004 for 16 cities which represent the full range of climate zones in the United States. The 50% goal is for site energy usage reduction. The weighted average is based on data on the building area of construction in the various climate locations. Cost-effectiveness of the EEMs is determined showing an average simple payback of 6.7 years for all 16 climate locations. An alternative set of results is provided which includes a variable air volume HVAC system that achieves at least 50% energy savings in 7 of the 16 climate zones with a construction area weighted average savings of 48.5%. Other packages of EEMs may also achieve 50% energy savings; this report does not consider all alternatives but rather presents at least one way to reach the goal. Design teams using this TSD should follow an integrated design approach and utilize additional analysis to evaluate the specific conditions of a project.

  7. Large Hospital 50% Energy Savings: Technical Support Document

    SciTech Connect

    Bonnema, E.; Studer, D.; Parker, A.; Pless, S.; Torcellini, P.

    2010-09-01

    This Technical Support Document documents the technical analysis and design guidance for large hospitals to achieve whole-building energy savings of at least 50% over ANSI/ASHRAE/IESNA Standard 90.1-2004 and represents a step toward determining how to provide design guidance for aggressive energy savings targets. This report documents the modeling methods used to demonstrate that the design recommendations meet or exceed the 50% goal. EnergyPlus was used to model the predicted energy performance of the baseline and low-energy buildings to verify that 50% energy savings are achievable. Percent energy savings are based on a nominal minimally code-compliant building and whole-building, net site energy use intensity. The report defines architectural-program characteristics for typical large hospitals, thereby defining a prototype model; creates baseline energy models for each climate zone that are elaborations of the prototype models and are minimally compliant with Standard 90.1-2004; creates a list of energy design measures that can be applied to the prototype model to create low-energy models; uses industry feedback to strengthen inputs for baseline energy models and energy design measures; and simulates low-energy models for each climate zone to show that when the energy design measures are applied to the prototype model, 50% energy savings (or more) are achieved.

  8. Potential energy savings from aquifer thermal energy storage

    SciTech Connect

    Anderson, M.R.; Weijo, R.O.

    1988-07-01

    Pacific Northwest Laboratory researchers developed an aggregate-level model to estimate the short- and long-term potential energy savings from using aquifer thermal storage (ATES) in the United States. The objectives of this effort were to (1) develop a basis from which to recommend whether heat or chill ATES should receive future research focus and (2) determine which market sector (residential, commercial, or industrial) offers the largest potential energy savings from ATES. Information was collected on the proportion of US land area suitable for ATES applications. The economic feasibility of ATES applications was then evaluated. The potential energy savings from ATES applications was calculated. Characteristic energy use in the residential, commercial, and industrial sectors was examined, as was the relationship between waste heat production and consumption by industrial end-users. These analyses provided the basis for two main conclusions: heat ATES applications offer higher potential for energy savings than do chill ATES applications; and the industrial sector can achieve the highest potential energy savings for the large consumption markets. Based on these findings, it is recommended that future ATES research and development efforts be directed toward heat ATES applications in the industrial sector. 11 refs., 6 figs., 9 tabs.

  9. Achieving Deeper Energy Savings in Federal Energy Performance Contracts

    DOE PAGESBeta

    Shonder, John A.; Nasseri, Cyrus

    2015-01-01

    Legislation requires each agency of the US federal government to reduce the aggregate energy use index of its buildings by 30% by 2015, with respect to a 2003 baseline. The declining availability of appropriated funding means that energy performance contracting will be key to achieving this goal. Historically however, energy performance contracts have been able to reduce energy use by only about 20% over baseline. Achieving 30% energy reductions using performance contracting will require new approaches and a specific focus on achieving higher energy savings, both by ESCOs and by agencies. This paper describes some of the ways federal agenciesmore » are meeting this challenge, and presents results from the efforts of one agency the US General Services Administration -- to achieve deeper energy savings in conventional energy savings performance contracts.« less

  10. Achieving Deeper Energy Savings in Federal Energy Performance Contracts

    SciTech Connect

    Shonder, John A.; Nasseri, Cyrus

    2015-01-01

    Legislation requires each agency of the US federal government to reduce the aggregate energy use index of its buildings by 30% by 2015, with respect to a 2003 baseline. The declining availability of appropriated funding means that energy performance contracting will be key to achieving this goal. Historically however, energy performance contracts have been able to reduce energy use by only about 20% over baseline. Achieving 30% energy reductions using performance contracting will require new approaches and a specific focus on achieving higher energy savings, both by ESCOs and by agencies. This paper describes some of the ways federal agencies are meeting this challenge, and presents results from the efforts of one agency the US General Services Administration -- to achieve deeper energy savings in conventional energy savings performance contracts.

  11. Energy savings potential from energy-conserving irrigation systems

    SciTech Connect

    Wilfert, G.L.; Patton, W.P.; Harrer, B.J.; Clark, M.A.

    1982-11-01

    This report systematically compares, within a consistent framework, the technical and economic characteristics of energy-conserving irrigation systems with those of conventional irrigation systems and to determine total energy savings. Levelized annual costs of owning and operating both energy-conserving and conventional irrigation systems have been developed and compared for all 17 states to account for the differences in energy costs and irrigation conditions in each state. Market penetration of energy-conserving systems is assessed for those systems having lower levelized annual costs than conventional systems performing the same function. Annual energy savings were computed by matching the energy savings per system with an assumed maximum market penetration of 100 percent in those markets where the levelized annual costs of energy-conserving systems are lower than the levelized annual costs of conventional systems.

  12. VO2 thermochromic smart window for energy savings and generation

    PubMed Central

    Zhou, Jiadong; Gao, Yanfeng; Zhang, Zongtao; Luo, Hongjie; Cao, Chuanxiang; Chen, Zhang; Dai, Lei; Liu, Xinling

    2013-01-01

    The ability to achieve energy saving in architectures and optimal solar energy utilisation affects the sustainable development of the human race. Traditional smart windows and solar cells cannot be combined into one device for energy saving and electricity generation. A VO2 film can respond to the environmental temperature to intelligently regulate infrared transmittance while maintaining visible transparency, and can be applied as a thermochromic smart window. Herein, we report for the first time a novel VO2-based smart window that partially utilises light scattering to solar cells around the glass panel for electricity generation. This smart window combines energy-saving and generation in one device, and offers potential to intelligently regulate and utilise solar radiation in an efficient manner. PMID:24157625

  13. VO₂ thermochromic smart window for energy savings and generation.

    PubMed

    Zhou, Jiadong; Gao, Yanfeng; Zhang, Zongtao; Luo, Hongjie; Cao, Chuanxiang; Chen, Zhang; Dai, Lei; Liu, Xinling

    2013-10-24

    The ability to achieve energy saving in architectures and optimal solar energy utilisation affects the sustainable development of the human race. Traditional smart windows and solar cells cannot be combined into one device for energy saving and electricity generation. A VO2 film can respond to the environmental temperature to intelligently regulate infrared transmittance while maintaining visible transparency, and can be applied as a thermochromic smart window. Herein, we report for the first time a novel VO2-based smart window that partially utilises light scattering to solar cells around the glass panel for electricity generation. This smart window combines energy-saving and generation in one device, and offers potential to intelligently regulate and utilise solar radiation in an efficient manner.

  14. VO₂ thermochromic smart window for energy savings and generation.

    PubMed

    Zhou, Jiadong; Gao, Yanfeng; Zhang, Zongtao; Luo, Hongjie; Cao, Chuanxiang; Chen, Zhang; Dai, Lei; Liu, Xinling

    2013-01-01

    The ability to achieve energy saving in architectures and optimal solar energy utilisation affects the sustainable development of the human race. Traditional smart windows and solar cells cannot be combined into one device for energy saving and electricity generation. A VO2 film can respond to the environmental temperature to intelligently regulate infrared transmittance while maintaining visible transparency, and can be applied as a thermochromic smart window. Herein, we report for the first time a novel VO2-based smart window that partially utilises light scattering to solar cells around the glass panel for electricity generation. This smart window combines energy-saving and generation in one device, and offers potential to intelligently regulate and utilise solar radiation in an efficient manner. PMID:24157625

  15. Modeled and metered energy savings from exterior wall insulation

    SciTech Connect

    Ternes, M.; Parker, D.; McLain, H.; Barkaszi, S. Jr.

    1996-09-01

    Millions of single-family masonry (block) houses with slab foundations exist in the southern United States. In fact, approximately 50% of Florida`s six million residences are of concrete block construction. The block walls in these homes are usually uninsulated, and the technology for retrofitting wall insulation is not well developed. Two field tests were performed--one near Phoenix, Arizona and one in Cocoa, Florida--to measure the air-conditioning energy savings and demand reduction impact of applying an exterior insulation and finish system (EEFS) to the exterior of the block wall, and gain practical experience with retrofit application techniques and costs. One field test used a {open_quotes}site-fabricated{close_quotes} insulation system, while the other field test used a commercially available system. The field tests measured a savings of 9% in Arizona and less savings in Florida, and emphasized the impact indoor temperature settings have on cooling energy savings: exterior wall insulation on block homes will produce energy savings in Florida houses only if a low cooling thermostat setting is desirable. The field tests also highlighted an improved comfort benefit from the retrofit - namely, elimination of overheating in rooms with south and west exposures. The DOE-2. ID program was used to analyze the energy savings (air-conditioning and heating) and electric demand impact of applying an EIFS. Air-conditioning energy savings were estimated to be in the range of 8% to 10% in many southern U.S. regions. A 12% savings was predicted for Phoenix, Arizona and a savings of 1% to 4% was predicted for seacoast regions, particularly in Florida. These predictions were in good agreement with the measured values. Peak hour cooling energy savings were predicted to be more uniform throughout the country, generally in the range of %8 to %12.

  16. Pharmacological screening of Coriandrum sativum Linn. for hepatoprotective activity

    PubMed Central

    Pandey, A.; Bigoniya, P.; Raj, V.; Patel, K. K.

    2011-01-01

    Objective: Coriandrum sativum (Linn.), a glabrous, aromatic, herbaceous annual plant, is well known for its use in jaundice. Essential oil, flavonoids, fatty acids, and sterols have been isolated from different parts of C. sativum. The plant has a very effective antioxidant profile showing 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, lipoxygenase inhibition, phospholipid peroxidation inhibition, iron chelating activity, hydroxyl radical scavenging activity, superoxide dismutation, glutathione reduction and antilipid peroxidation due to its high total phenolic content with the presence of constituents like pyrogallol, caffeic acid, glycitin, etc. Materials and Methods: This study was aimed at investigating the hepatoprotective activity of C. sativum against carbon tetrachloride (CCl4), with estimation of serum serum glutamyl oxaloacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT), alkaine phosphatase (ALP) and bilirubin, and with liver histopathology. Results: Ethanolic extract was found to be rich in alkaloids, phenolic compounds and flavonoids, and high performance liquid chromatography (HPLC) fingerprinting showed the presence of iso-quercetin and quercetin. C. sativum signifies hepatoprotection by reducing the liver weight, activities of SGOT, SGPT, and ALP, and direct bilirubin of CCl4 intoxicated animals. Administration of C. sativum extract at 300 mg/kg dose resulted in disappearance of fatty deposit, ballooning degeneration and necrosis, indicating antihepatotoxic activity. Conclusion: The results of this study have led to the conclusion that ethanolic extract of C. sativum possesses hepatoprotective activity which may be due to the antioxidant potential of phenolic compounds. PMID:21966166

  17. Antioxidant and hepatoprotective effects of Boswellia ovalifoliolata bark extracts.

    PubMed

    Mahesh, Bandari Uma; Shrivastava, Shweta; Pragada, Rajeswara Rao; Naidu, V G M; Sistla, Ramakrishna

    2014-09-01

    Paracetamol (PCM) hepatotoxicity is related to reactive oxygen species (ROS) formation and excessive oxidative stress; natural antioxidant compounds have been tested as an alternative therapy. This study evaluated the hepatoprotective activity of an alcoholic extract of Boswellia ovalifoliolata (BO) bark against PCM-induced hepatotoxicity. BO extract also demonstrated antioxidant activity in vitro, as well as scavenger activity against 2, 2-diphenyl-1-picrylhydrazyl. Administration of PCM caused a significant increase in the release of transaminases, alkaline phosphatase, and lactate dehydrogenase in serum. Significant enhancement in hepatic lipid peroxidation and marked depletion in reduced glutathione were observed after parac intoxication with severe alterations in liver histology. BO treatment was able to mitigate hepatic damage induced by acute intoxication of PCM and showed a pronounced protective effect against lipid peroxidation, deviated serum enzymatic variables, and maintained glutathione status toward control. The results clearly demonstrate the hepatoprotective effect of BO against the toxicity induced by PCM. PMID:25263977

  18. Delivering energy savings through community-based Organizations

    SciTech Connect

    Berry, David

    2010-11-15

    To achieve greater energy savings through energy efficiency programs, participation in those programs must increase. Community-based organizations provide a potentially effective way to reach more residential and small commercial consumers and increase the adoption of energy efficiency measures. (author)

  19. Compact cities: energy saving strategies for the eighties

    SciTech Connect

    Not Available

    1980-07-01

    This report is concerned with energy and urban form. One specific focus is on energy-saving land use patterns: how to halt urban sprawl with its excessive energy consumption. The second focus is on appropriate renewable energy sources and conservation incentives for cities.

  20. Intrinsic Changes: Energy Saving Behaviour among Resident University Students

    ERIC Educational Resources Information Center

    Black, Rosemary; Davidson, Penny; Retra, Karen

    2010-01-01

    This paper presents the results of a study that explored the effectiveness of three intervention strategies in facilitating energy saving behaviour among resident undergraduate university students. In contrast to a dominant practice of motivating with rewards or competition this study sought to appeal to students' intrinsic motivations. An…

  1. 48 CFR 23.205 - Energy-savings performance contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... provided in 10 CFR part 436, subpart B; at http://www1.eere.energy.gov/femp/financing/espcs_regulations...) Except as provided in 10 CFR 436.34, ESPC's are subject to subpart 17.1. (c) To solicit and award an ESPC... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Energy-savings...

  2. 48 CFR 23.205 - Energy-savings performance contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... provided in 10 CFR part 436, subpart B; at http://www1.eere.energy.gov/femp/financing/espcs_regulations...) Except as provided in 10 CFR 436.34, ESPC's are subject to subpart 17.1. (c) To solicit and award an ESPC... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Energy-savings...

  3. Iridoids from Neopicrorhiza scrophulariiflora and their hepatoprotective activities in vitro.

    PubMed

    Wang, Hao; Wu, Fei-Hua; Xiong, Fei; Wu, Jia-Jun; Zhang, Lu-Yong; Ye, Wen-Cai; Li, Ping; Zhao, Shou-Xun

    2006-08-01

    Four new non-glycosidic iridoids, piscrocins D (1), E (2), F (6), and G (7), as well as two new iridoid glycosides, piscrosides A (8) and B (9), were isolated from the roots of Neopicrorhiza scrophulariiflora (Scrophulariaceae), together with seven known iridoids. The structures of the isolated compounds were established by means of 1D and 2D NMR spectroscopy and chemical methods. The hepatoprotective activities of these compounds were evaluated by measuring their effects on CCl(4)-induced hepatocytes damage in vitro, and the structure-activity relationships were also discussed.

  4. An evaluation of the Fort Polk energy savings performance contract

    SciTech Connect

    Hughes, P.J.; Shonder, J.A.

    1998-11-01

    The US Army, in cooperation with an energy services company (ESCO), used private capital to retrofit 4,003 family housing units on the Fort Polk, Louisiana, military base with geothermal heat pumps (GHPs). The project was performed under an energy savings performance contract (ESPC) that provides for the Army and the ESCO to share the cost savings realized through the energy retrofit over the 20-year life of the contract. Under the terms of the contract, the ESCO is responsible for maintaining the GHPs and provides ongoing measurement and verification (M and V) to assure cost and energy savings to the Army. An independent evaluation conducted by the Department of Energy`s Oak Ridge National Laboratory indicates that the GHP systems in combination with other energy retrofit measures have reduced annual whole-community electrical consumption by 33%, and natural gas consumption by 100%. These energy savings correspond to an estimated reduction in CO{sub 2} emissions of 22,400 tons per year. Peak electrical demand has been reduced by 43%. The electrical energy and demand savings correspond to an improvement in the whole-community annual electric load factor from 0.52 to 0.62. As a result of the project, Fort Polk saves about $450,000 annually and benefits from complete renewal of the major energy consuming systems in family housing and maintenance of those systems for 20 years. Given the magnitude of the project, the cost and energy savings achieved, and the lessons learned during its design and implementation, the Fort Polk ESPC can provide a model for other housing-related energy savings performance contracts in both the public and private sectors.

  5. Aerodynamic Drag and Drag Reduction: Energy and Energy Savings (Invited)

    NASA Technical Reports Server (NTRS)

    Wood, Richard M.

    2003-01-01

    An assessment of the role of fluid dynamic resistance and/or aerodynamic drag and the relationship to energy use in the United States is presented. Existing data indicates that up to 25% of the total energy consumed in the United States is used to overcome aerodynamic drag, 27% of the total energy used in the United States is consumed by transportation systems, and 60% of the transportation energy or 16% of the total energy consumed in the United States is used to overcome aerodynamic drag in transportation systems. Drag reduction goals of 50% are proposed and discussed which if realized would produce a 7.85% total energy savings. This energy savings correlates to a yearly cost savings in the $30Billion dollar range.

  6. Energy saving through trail following in a marine snail.

    PubMed

    Davies, Mark S; Blackwell, Janine

    2007-05-01

    Most snails and slugs locomote over a layer of mucus and although the resultant mucus trail is expensive to produce, we show that this expense can be reduced by trail following. When tracking over fresh conspecific trails, the marine intertidal snail Littorina littorea (L.) produced only approximately 27% of the mucus laid by marker snails. When tracking over weathered trails, snails adjusted their mucus production to recreate a convex trail profile of similar shape and thickness to the trail as originally laid. Maximum energy saving occurs when following recently laid trails which are little weathered. Many and diverse ecological roles for trail following have been proposed. Energy saving is the only role that applies across the Gastropoda and so may help to explain why trail following is such a well-established behaviour. PMID:17327203

  7. Energy Saving Glass Lamination via Selective Radio-Frequency Heating

    SciTech Connect

    Shulman, Holly S.; Allan, Shawn M.

    2009-11-11

    This Inventions and Innovations program supported the technical and commercial research and development needed to elevate Ceralink's energy saving process for flat glass lamination from bench scale to a self-supporting technology with significant potential for growth. Radio-frequency heating was any un-explored option for laminating glass prior to this program. With significant commercial success through time and energy savings in the wood, paper, and plastics industries, RF heating was found to have significant promise for the energy intensive glass lamination industry. A major technical goal of the program was to demonstrate RF lamination across a wide range of laminate sizes and materials. This was successfully accomplished, dispelling many skeptics' concerns about the abilities of the technology. Ceralink laminated panels up to 2 ft x 3 ft, with four sets processed simultaneously, in a 3 minute cycle. All major categories of interlayer materials were found to work with RF lamination. In addition to laminating glass, other materials including photovoltaic silicon solar cells, light emitting diodes, metallized glass, plastics (acrylic and polycarbonate), and ceramics (alumina) were found compatible with the RF process. This opens up a wide range of commercial opportunities beyond the initially targeted automotive industry. The dramatic energy savings reported for RF lamination at the bench scale were found to be maintained through the scale up of the process. Even at 2 ft x 3 ft panel sizes, energy savings are estimated to be at least 90% compared to autoclaving or vacuum lamination. With targeted promotion through conference presentations, press releases and internet presence, RF lamination has gained significant attention, drawing large audiences at American Ceramic Society meetings. The commercialization success of the project includes the establishment of a revenue-generating business model for providing process development and demonstrations for potential RF

  8. Investigating energy-saving potentials in the cloud.

    PubMed

    Lee, Da-Sheng

    2014-01-01

    Collecting webpage messages can serve as a sensor for investigating the energy-saving potential of buildings. Focusing on stores, a cloud sensor system is developed to collect data and determine their energy-saving potential. The owner of a store under investigation must register online, report the store address, area, and the customer ID number on the electric meter. The cloud sensor system automatically surveys the energy usage records by connecting to the power company website and calculating the energy use index (EUI) of the store. Other data includes the chain store check, company capital, location price, and the influence of weather conditions on the store; even the exposure frequency of store under investigation may impact the energy usage collected online. After collecting data from numerous stores, a multi-dimensional data array is constructed to determine energy-saving potential by identifying stores with similarity conditions. Similarity conditions refer to analyzed results that indicate that two stores have similar capital, business scale, weather conditions, and exposure frequency on web. Calculating the EUI difference or pure technical efficiency of stores, the energy-saving potential is determined. In this study, a real case study is performed. An 8-dimensional (8D) data array is constructed by surveying web data related to 67 stores. Then, this study investigated the savings potential of the 33 stores, using a site visit, and employed the cloud sensor system to determine the saving potential. The case study results show good agreement between the data obtained by the site visit and the cloud investigation, with errors within 4.17%. Among 33 the samples, eight stores have low saving potentials of less than 5%. The developed sensor on the cloud successfully identifies them as having low saving potential and avoids wasting money on the site visit. PMID:24561405

  9. A preliminary review of energy savings from EADC plant audits

    SciTech Connect

    Wilfert, G.L.; Kinzey, B.R.; Kaae, P.S.

    1993-01-01

    This paper reviews the long-term energy savings attributed to industrial plant energy audits conducted under the US Department of Energy's (DOE's) Energy Analysis and Diagnostic Center (EADC) Program. By the end of FY91, this program is expected to have performed over 3600 plant energy audits since it began in late 1976. During FY91, 500 of the 3600 are expected to be completed. Currently, 18 universities participate in the program. DOE's expansion plan, as specified in the National Energy Strategy, calls for adding three universities to the program during FY92. This review, requested by the OIT as part of their program planning effort, is preliminary and limited in scope. The primary purpose of this paper is to independently assess the accuracy of past energy savings reporting, specifically: whether a 2-year assessment horizon for identifying implemented ECOs captures all the ECOs implemented under the program whether the number of implemented ECOs and thus, the energy savings associated with program audits, significantly decrease in years 3 through 7 after the audit.

  10. A preliminary review of energy savings from EADC plant audits

    SciTech Connect

    Wilfert, G.L.; Kinzey, B.R.; Kaae, P.S.

    1993-03-01

    This paper reviews the long-term energy savings attributed to industrial plant energy audits conducted under the US Department of Energy`s (DOE`s) Energy Analysis and Diagnostic Center (EADC) Program. By the end of FY91, this program is expected to have performed over 3600 plant energy audits since it began in late 1976. During FY91, 500 of the 3600 are expected to be completed. Currently, 18 universities participate in the program. DOE`s expansion plan, as specified in the National Energy Strategy, calls for adding three universities to the program during FY92. This review, requested by the OIT as part of their program planning effort, is preliminary and limited in scope. The primary purpose of this paper is to independently assess the accuracy of past energy savings reporting, specifically: whether a 2-year assessment horizon for identifying implemented ECOs captures all the ECOs implemented under the program whether the number of implemented ECOs and thus, the energy savings associated with program audits, significantly decrease in years 3 through 7 after the audit.

  11. Review of natural products with hepatoprotective effects.

    PubMed

    Madrigal-Santillán, Eduardo; Madrigal-Bujaidar, Eduardo; Álvarez-González, Isela; Sumaya-Martínez, María Teresa; Gutiérrez-Salinas, José; Bautista, Mirandeli; Morales-González, Ángel; García-Luna y González-Rubio, Manuel; Aguilar-Faisal, J Leopoldo; Morales-González, José A

    2014-10-28

    The liver is one of the most important organs in the body, performing a fundamental role in the regulation of diverse processes, among which the metabolism, secretion, storage, and detoxification of endogenous and exogenous substances are prominent. Due to these functions, hepatic diseases continue to be among the main threats to public health, and they remain problems throughout the world. Despite enormous advances in modern medicine, there are no completely effective drugs that stimulate hepatic function, that offer complete protection of the organ, or that help to regenerate hepatic cells. Thus, it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases, with the aim of these alternatives being more effective and less toxic. The use of some plants and the consumption of different fruits have played basic roles in human health care, and diverse scientific investigations have indicated that, in those plants and fruits so identified, their beneficial effects can be attributed to the presence of chemical compounds that are called phytochemicals. The present review had as its objective the collecting of data based on research conducted into some fruits (grapefruit, cranberries, and grapes) and plants [cactus pear (nopal) and cactus pear fruit, chamomile, silymarin, and spirulina], which are consumed frequently by humans and which have demonstrated hepatoprotective capacity, as well as an analysis of a resin (propolis) and some phytochemicals extracted from fruits, plants, yeasts, and algae, which have been evaluated in different models of hepatotoxicity. PMID:25356040

  12. Review of natural products with hepatoprotective effects

    PubMed Central

    Madrigal-Santillán, Eduardo; Madrigal-Bujaidar, Eduardo; Álvarez-González, Isela; Sumaya-Martínez, María Teresa; Gutiérrez-Salinas, José; Bautista, Mirandeli; Morales-González, Ángel; García-Luna y González-Rubio, Manuel; Aguilar-Faisal, J Leopoldo; Morales-González, José A

    2014-01-01

    The liver is one of the most important organs in the body, performing a fundamental role in the regulation of diverse processes, among which the metabolism, secretion, storage, and detoxification of endogenous and exogenous substances are prominent. Due to these functions, hepatic diseases continue to be among the main threats to public health, and they remain problems throughout the world. Despite enormous advances in modern medicine, there are no completely effective drugs that stimulate hepatic function, that offer complete protection of the organ, or that help to regenerate hepatic cells. Thus, it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases, with the aim of these alternatives being more effective and less toxic. The use of some plants and the consumption of different fruits have played basic roles in human health care, and diverse scientific investigations have indicated that, in those plants and fruits so identified, their beneficial effects can be attributed to the presence of chemical compounds that are called phytochemicals. The present review had as its objective the collecting of data based on research conducted into some fruits (grapefruit, cranberries, and grapes) and plants [cactus pear (nopal) and cactus pear fruit, chamomile, silymarin, and spirulina], which are consumed frequently by humans and which have demonstrated hepatoprotective capacity, as well as an analysis of a resin (propolis) and some phytochemicals extracted from fruits, plants, yeasts, and algae, which have been evaluated in different models of hepatotoxicity. PMID:25356040

  13. Triterpenoids of Ganoderma theaecolum and their hepatoprotective activities.

    PubMed

    Liu, Li-Ying; Chen, Hui; Liu, Chao; Wang, Hong-Qing; Kang, Jie; Li, Yan; Chen, Ruo-Yun

    2014-10-01

    Five new lanostane triterpenoids, ganoderic acid XL1 (1), ganoderic acid XL2 (2), 20-hydroxy-ganoderic acid AM1 (3), ganoderenic acid AM1 (4) and ganoderesin C (5), together with five known triterpenoids (6-10) were isolated from the fruiting bodies of Ganoderma theaecolum. Chemical structures were elucidated on the basis of spectroscopic evidence, including 1D, 2D NMR, mass spectrometric data and circular dichroism spectra. Compounds 1, 4, 5, 8, 9 and 10 (10 μM) exhibited hepatoprotective activities against DL-galactosamine-induced cell damage in HL-7702 cells.

  14. Hepatoprotective diterpenoids from the roots of Salvia grandifolia.

    PubMed

    Kang, Jie; Zhang, Ting; Li, Li; Sun, Hua; Wang, Ding-Ding; Chen, Ruo-Yun

    2016-05-01

    One new diterpenoid, grandifolia G (1), together with a known diterpenoid (6,7,8,8a-tetrahydro-6,6-dimethyl-2-oxonaphtho[1,8-bc]furan-3-yl)-4-methylfuran-3-carboxylic acid (2), was isolated from 70% EtOH extract of root of Salvia grandifolia. Their structures were determined by UV, IR, HRESIMS, NMR spectra. Compounds 1 and 2 (10 μM) exhibited hepatoprotective activities (61 and 55%) against DL-galactosamine-induced cell damage in HL-7702 cells. PMID:27086714

  15. Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.*

    PubMed Central

    Gao, Jie; Sun, Cui-rong; Yang, Jie-hong; Shi, Jian-mei; Du, Yue-guang; Zhang, Yu-yan; Li, Jin-hui; Wan, Hai-tong

    2011-01-01

    The hepatoprotective and antioxidant activities of the n-butanol extract of Rubus parvifolius L. (RPL), a widely used medicinal plant, were evaluated. Results demonstrated that RPL extract possessed pronounced hepatoprotective effects against carbon tetrachloride (CCl4)-induced hepatic injury in mice, which was at least partially attributed to its strong antioxidant capacity. Treatment with RPL extract markedly attenuated the increases in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels caused by CCl4 intoxication. It also significantly prevented the decrease in superoxide dismutase (SOD) activity and the increase in malondialdehyde (MDA) content of liver tissue. Meanwhile, histopathological changes of hepatic damage were also remarkably ameliorated. Phytochemical analysis based on high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) revealed the presence of various phenolic compounds, including caffeic acid conjugates, ellagic acid glycosides, and flavonol glycosides, which might be responsible for the hepatoprotective and antioxidant activities of RPL. PMID:21265045

  16. Energy savings potential in air conditioners and chiller systems

    DOE PAGESBeta

    Kaya, Durmus; Alidrisi, Hisham

    2014-01-22

    In the current paper we quantified and evaluated the energy saving potential in air conditioners and chiller systems. Here, we also showed how to reduce the cost of air conditioners and chiller systems in existing facilities on the basis of payback periods. Among the measures investigated were: (1) installing higher efficiency air conditioners, (2) installing higher efficiency chillers, (3) duty cycling air conditioning units, and (4) utilizing existing economizers on air conditioning units. For each method, examples were provided from Arizona, USA. In these examples, the amount of saved energy, the financial evaluation of this energy, and the investment costmore » and pay back periods were calculated.« less

  17. Energy savings potential in air conditioners and chiller systems

    SciTech Connect

    Kaya, Durmus; Alidrisi, Hisham

    2014-01-22

    In the current paper we quantified and evaluated the energy saving potential in air conditioners and chiller systems. Here, we also showed how to reduce the cost of air conditioners and chiller systems in existing facilities on the basis of payback periods. Among the measures investigated were: (1) installing higher efficiency air conditioners, (2) installing higher efficiency chillers, (3) duty cycling air conditioning units, and (4) utilizing existing economizers on air conditioning units. For each method, examples were provided from Arizona, USA. In these examples, the amount of saved energy, the financial evaluation of this energy, and the investment cost and pay back periods were calculated.

  18. New energy saving system for future LNG carriers

    SciTech Connect

    Kahara, Susumu; Suetake, Yoshihiro; Ishimaru, Junshiro; Hiraoka, Kazuyoshi

    1994-12-31

    Steam turbine plant, which burns BOG (Boil-Off Gas) as fuel, has bene installed for LNG carriers with the necessity of disposing BOG safely. Are other plants unpractical for LNG carriers? To answer to this question, this paper evaluates (1) dual fuel diesel, (2) diesel with reliquefaction plant, (3) diesel with auxiliary boiler and power assist motor, (4) gas turbine/steam turbine and (5) steam turbine with CRP (Contra Rotating Propeller) from several aspects, such as safety and reliability, maintainability and operability, economy and effect on environment. Based on the above studies, this paper proposes Steam turbine with CRP plant as a new energy saving system for future LNG carriers.

  19. Energy Savings Assessment for Digital-to-Analog Converter Boxes

    SciTech Connect

    Cheung, Hoi Ying Iris; Meier, Alan; Brown, Richard

    2011-01-18

    The Digital Television (DTV) Converter Box Coupon Program was administered by the U.S. government to subsidize purchases of digital-to-analog converter boxes, with up to two $40 coupons for each eligible household. In order to qualify as Coupon Eligible Converter Boxes (CECBs), these devices had to meet a number of minimum performance specifications, including energy efficiency standards. The Energy Star Program also established voluntary energy efficiency specifications that are more stringent than the CECB requirements. In this study, we measured the power and energy consumptions for a sample of 12 CECBs (including 6 Energy Star labeled models) in-use in homes and estimated aggregate energy savings produced by the energy efficiency policies. Based on the 35 million coupons redeemed through the end of the program, our analysis indicates that between 2500 and 3700 GWh per year are saved as a result of the energy efficiency policies implemented on digital-to-analog converter boxes. The energy savings generated are equivalent to the annual electricity use of 280,000 average US homes.

  20. Energy-saving approaches to solid state street lighting

    NASA Astrophysics Data System (ADS)

    Vitta, Pranciškus; Stanikūnas, Rytis; Tuzikas, Arūnas; Reklaitis, Ignas; Stonkus, Andrius; Petrulis, Andrius; Vaitkevičius, Henrikas; Žukauskas, Artūras

    2011-10-01

    We consider the energy-saving potential of solid-state street lighting due to improved visual performance, weather sensitive luminance control and tracking of pedestrians and vehicles. A psychophysical experiment on the measurement of reaction time with a decision making task was performed under mesopic levels of illumination provided by a highpressure sodium (HPS) lamp and different solid-state light sources, such as daylight and warm-white phosphor converted light-emitting diodes (LEDs) and red-green-blue LED clusters. The results of the experiment imply that photopic luminances of road surface provided by solid-state light sources with an optimized spectral power distribution might be up to twice as low as those provided by the HPS lamp. Dynamical correction of road luminance against road surface conditions typical of Lithuanian climate was estimated to save about 20% of energy in comparison with constant-level illumination. The estimated energy savings due to the tracking of pedestrians and vehicles amount at least 25% with the cumulative effect of intelligent control of at least 40%. A solid-state street lighting system with intelligent control was demonstrated using a 300 m long test ground consisting of 10 solid-state street luminaires, a meteorological station and microwave motion sensor network operated via power line communication.

  1. Incorporating Non-energy Benefits into Energy Savings Performance Contracts

    SciTech Connect

    Larsen, Peter; Goldman, Charles; Gilligan, Donald; Singer, Terry

    2012-06-01

    This paper evaluates the issue of non-energy benefits within the context of the U.S. energy services company (ESCO) industry?a growing industry comprised of companies that provide energy savings and other benefits to customers through the use of performance-based contracting. Recent analysis has found that ESCO projects in the public/institutional sector, especially at K-12 schools, are using performance-based contracting, at the behest of the customers, to partially -- but not fully -- offset substantial accumulated deferred maintenance needs (e.g., asbestos removal, wiring) and measures that have very long paybacks (roof replacement). This trend is affecting the traditional economic measures policymakers use to evaluate success on a benefit to cost basis. Moreover, the value of non-energy benefits which can offset some or all of the cost of the non-energy measures -- including operations and maintenance (O&M) savings, avoided capital costs, and tradable pollution emissions allowances-- are not always incorporated into a formal cost-effectiveness analysis of ESCO projects. Nonenergy benefits are clearly important to customers, but state and federal laws that govern the acceptance of these types of benefits for ESCO projects vary widely (i.e., 0-100percent of allowable savings can come from one or more non-energy categories). Clear and consistent guidance on what types of savings are recognized in Energy Savings agreements under performance contracts is necessary, particularly where customers are searching for deep energy efficiency gains in the building sector.

  2. Energy Savings from GSA's National Deep Retrofit Program

    SciTech Connect

    Shonder, John A

    2014-09-01

    Under its National Deep Energy Retrofit (NDER) program, the U.S. General Services Administration (GSA) awarded 10 ESPC projects with the objectives of using innovative technologies and renewable energy technologies, and moving buildings toward net zero energy consumption. This report analyzes data on energy savings from the 10 NDER projects, and compares them with the savings of a sample of other recently awarded Federal ESPC projects. It is shown that by emphasizing the need for deeper energy savings, and by the establishment of a central Project Management Office (PMO) to provide authoritative contracting, technical and pricing assistance, the NDER projects achieved an average level of savings more than twice that of the other Federal ESPC projects. The level of savings achieved in each project seems to be dependent more on the availability of ECMs at the site than on energy price, energy cost per square foot, pre-retrofit EUI or the length of the contract term. This suggests that GSA can achieve similar results in a wide variety of building

  3. An Energy Saving System for a Beam Pumping Unit.

    PubMed

    Lv, Hongqiang; Liu, Jun; Han, Jiuqiang; Jiang, An

    2016-01-01

    Beam pumping units are widely used in the oil production industry, but the energy efficiency of this artificial lift machinery is generally low, especially for the low-production well and high-production well in the later stage. There are a number of ways for energy savings in pumping units, with the periodic adjustment of stroke speed and rectification of balance deviation being two important methods. In the paper, an energy saving system for a beam pumping unit (ESS-BPU) based on the Internet of Things (IoT) was proposed. A total of four types of sensors, including load sensor, angle sensor, voltage sensor, and current sensor, were used to detect the operating conditions of the pumping unit. Data from these sensors was fed into a controller installed in an oilfield to adjust the stroke speed automatically and estimate the degree of balance in real-time. Additionally, remote supervision could be fulfilled using a browser on a computer or smartphone. Furthermore, the data from a practical application was recorded and analyzed, and it can be seen that ESS-BPU is helpful in reducing energy loss caused by unnecessarily high stroke speed and a poor degree of balance. PMID:27187402

  4. Energy savings through improved irrigation practices. Final report

    SciTech Connect

    Gilley, J.R.; Supalla, R.J.

    1981-07-31

    In view of importance of energy to irrigated agriculture, the objectives of this project were: (1) determine the potential energy savings from alternative irrigation management practices; and (2) evaluate the economic benefits which would occur to irrigators from adopting these energy saving practices. These objectives were pursued for a selected array of irrigation situations typical of DOE Region VII. The analysis consists essentially of three parts, including the potential for improved energy efficiency with surface irrigation systems (gated pipe), the potential for enhanced energy efficiency with sprinkler systems, and a comparison of alternative irrigation systems. For gated-pipe surface systems, the energy conservation alternatives considered were: (1) increasing pump performance; (2) improving irrigation efficiency; and (3) water management. The alternatives considered for center-pivot sprinkler systems included conversion to low pressure, as well as pump performance, irrigation efficiency and water management. The analysis of alternative systems involved computing the energy and dollar savings associated with shifting from gated-pipe to one of four types of sprinkler systems: high-pressure center-pivot, low-pressure center-pivot, corner center-pivot, and continuous move lateral. The above alternatives were analyzed for an array of given conditions. These included combinations of three lifts (8, 35 and 75 meters) and two net irrigation requirements (33 to 66 cm for surface system and 25 and 50 cm for sprinkler systems). These conditions encompass nearly the full range of circumstances found in DOE Region VII.

  5. An Energy Saving System for a Beam Pumping Unit

    PubMed Central

    Lv, Hongqiang; Liu, Jun; Han, Jiuqiang; Jiang, An

    2016-01-01

    Beam pumping units are widely used in the oil production industry, but the energy efficiency of this artificial lift machinery is generally low, especially for the low-production well and high-production well in the later stage. There are a number of ways for energy savings in pumping units, with the periodic adjustment of stroke speed and rectification of balance deviation being two important methods. In the paper, an energy saving system for a beam pumping unit (ESS-BPU) based on the Internet of Things (IoT) was proposed. A total of four types of sensors, including load sensor, angle sensor, voltage sensor, and current sensor, were used to detect the operating conditions of the pumping unit. Data from these sensors was fed into a controller installed in an oilfield to adjust the stroke speed automatically and estimate the degree of balance in real-time. Additionally, remote supervision could be fulfilled using a browser on a computer or smartphone. Furthermore, the data from a practical application was recorded and analyzed, and it can be seen that ESS-BPU is helpful in reducing energy loss caused by unnecessarily high stroke speed and a poor degree of balance. PMID:27187402

  6. Impact evaluation methods for the energy savings plan

    SciTech Connect

    Spanner, G.E. ); Riewer, S. )

    1990-09-01

    The Energy $avings Plan (E$P) is Bonneville Power Administration's (Bonneville) retrofit program for the industrial sector. The program pays incentives for energy conservation measures involving electrical energy efficiency improvements in manufacturing, processing, and refining industries. E$P is an outgrowth of the Industrial Test Program and the Sponsor-Designed Program, two programs offered by Bonneville that involved installing energy conservation measures in industrial firms. This paper will describe the E$P program, discuss the first process evaluation findings, report the findings from a sample of four E$P project impact evaluations, and describe the techniques selected to evaluate the retrofits. The impact evaluations will provide a framework for assessing the energy savings achieved by the projects implemented under the E$P. In addition to energy savings, the evaluations will review process changes, net utility impacts, levelized costs, and free-riders.'' The four E$P projects evaluated include: a waste heat recovery system for a food processing blancher, an energy management control system used to upgrade refrigeration, a variable speed drive for a fan motor in a lumber mill, and a sludge screw press for waste water treatment.

  7. An Energy Saving System for a Beam Pumping Unit.

    PubMed

    Lv, Hongqiang; Liu, Jun; Han, Jiuqiang; Jiang, An

    2016-05-13

    Beam pumping units are widely used in the oil production industry, but the energy efficiency of this artificial lift machinery is generally low, especially for the low-production well and high-production well in the later stage. There are a number of ways for energy savings in pumping units, with the periodic adjustment of stroke speed and rectification of balance deviation being two important methods. In the paper, an energy saving system for a beam pumping unit (ESS-BPU) based on the Internet of Things (IoT) was proposed. A total of four types of sensors, including load sensor, angle sensor, voltage sensor, and current sensor, were used to detect the operating conditions of the pumping unit. Data from these sensors was fed into a controller installed in an oilfield to adjust the stroke speed automatically and estimate the degree of balance in real-time. Additionally, remote supervision could be fulfilled using a browser on a computer or smartphone. Furthermore, the data from a practical application was recorded and analyzed, and it can be seen that ESS-BPU is helpful in reducing energy loss caused by unnecessarily high stroke speed and a poor degree of balance.

  8. Energy conservation, energy efficiency and energy savings regulatory hypotheses - taxation, subsidies and underlying economics

    SciTech Connect

    Trumpy, T.

    1995-12-01

    More efficient use of energy resources can be promoted by various regulatory means, i.e., taxation, subsidies, and pricing. Various incentives can be provided by income and revenue tax breaks-deductible energy audit fees, energy saving investment credits, breaks for energy saving entrepreneurs, and energy savings accounts run through utility accounts. Value added and excise taxes can also be adjusted to reward energy saving investments and energy saving entrepreneurial activity. Incentives can be provided in the form of cash refunds, including trade-in-and-scrap programs and reimbursements or subsidies on audit costs and liability insurance. Pricing incentives include lower rates for less energy use, prepayment of deposit related to peak load use, electronically dispatched multiple tariffs, savings credits based on prior peak use, and subsidized {open_quotes}leasing{close_quotes} of more efficient appliances and lights. Credits, with an emphasis on pooling small loans, and 5-year energy savings contracts are also discussed.

  9. Hepatoprotective constituents of Firmiana simplex stem bark against ethanol insult to primary rat hepatocytes

    PubMed Central

    Kim, Jung Wha; Yang, Heejung; Cho, Namki; Kim, Bitnarae; Kim, Young Choong; Sung, Sang Hyun

    2015-01-01

    Background: Ethanol causes hepatic cellular damage by alterations in biological functions. This study evaluated the hepatoprotective potential of the methanolic extract originating from Firmiana simplex (Sterculiaceae) stem bark against the ethanol-induced hepatotoxicity in rat primary hepatocytes. Materials and Methods: The extract of F. simplex stem bark was successively fractionated into n-hexane, chloroform, ethyl acetate (EtOAc), and n-butanol. Column chromatography with silica gel and sephadex LH-20 was used to isolate the EtOAc fraction. Rat primary hepatocytes were cultured to study the hepatoprotective activity of isolated substances against ethanol-induced toxicity. Intracellular reactive oxygen species (ROS) levels, the antioxidant activities of glutathione reductase (GR) and glutathione peroxidase (GSH-PX) enzymes, and the GSH content were measured to examine the antioxidative property of the isolated compounds. Results: Two flavonoid glycosides, quercitrin (1) and tamarixetin 3-O-rhamnopyranoside (2), were isolated from the active EtOAc fraction. Compound 1 significantly protected rat primary hepatocytes against ethanol-induced oxidative stress by reducing the intracellular ROS level and preserving antioxidative defense systems such as GR, GSH-PX, and total GSH. Conclusion: This is the first report on the hepatoprotective activities of the extract of F. simplex. The EtOAc fraction of F. simplex stem bark and its major constituent quercitrin (1) could function as hepatoprotective agents to attenuate the development of alcoholic liver disease. PMID:25709211

  10. Bandwidth Study on Energy Use and Potential Energy Saving Opportunities in U.S. Chemical Manufacturing

    SciTech Connect

    Sabine Brueske, Caroline Kramer, Aaron Fisher

    2015-06-01

    Energy bandwidth studies of U.S. manufacturing sectors can serve as foundational references in framing the range (or bandwidth) of potential energy savings opportunities. This bandwidth study examines energy consumption and potential energy savings opportunities in U.S. chemical manufacturing. The study relies on multiple sources to estimate the energy used in the production of 74 individual chemicals, representing 57% of sector-wide energy consumption. Energy savings opportunities for individual chemicals and for 15 subsectors of chemicals manufacturing are based on technologies currently in use or under development; these potential savings are then extrapolated to estimate sector-wide energy savings opportunity.

  11. Bandwidth Study on Energy Use and Potential Energy Savings Opportunities in U.S. Petroleum Refining

    SciTech Connect

    Sabine Brueske, Caroline Kramer, Aaron Fisher

    2015-06-01

    Energy bandwidth studies of U.S. manufacturing sectors can serve as foundational references in framing the range (or bandwidth) of potential energy savings opportunities. This bandwidth study examines energy consumption and potential energy savings opportunities in U.S. petroleum refining. The study relies on multiple sources to estimate the energy used in nine individual process areas, representing 68% of sector-wide energy consumption. Energy savings opportunities for individual processes are based on technologies currently in use or under development; these potential savings are then extrapolated to estimate sector-wide energy savings opportunity.

  12. A CLS-based survivable and energy-saving WDM-PON architecture

    NASA Astrophysics Data System (ADS)

    Zhu, Min; Zhong, Wen-De; Zhang, Zhenrong; Luan, Feng

    2013-11-01

    We propose and demonstrate an improved survivable and energy-saving WDM-PON with colorless ONUs. It incorporates both energy-saving and self-healing operations. A simple effective energy-saving scheme is proposed by including an energy-saving control unit in the OLT and a control unit at each ONU. The energy-saving scheme realizes both dozing and sleep (offline) modes, which greatly improves the energy-saving efficiency for WDM-PONs. An intelligent protection switching scheme is designed in the OLT, which can distinguish if an ONU is in dozing/sleep (offline) state or a fiber is faulty. Moreover, by monitoring the optical power of each channel on both working and protection paths, the OLT can know the connection status of every fiber path, thus facilitating an effective protection switching and a faster failure recovery. The improved WDM-PON architecture not only significantly reduces energy consumption, but also performs self-healing operation in practical operation scenarios. The scheme feasibility is experimentally verified with 10 Gbit/s downstream and 1.25 Gbit/s upstream transmissions. We also examine the energy-saving efficiency of our proposed energy-saving scheme by simulation, which reveals that energy saving mainly arises from the dozing mode, not from the sleep mode when the ONU is in the online state.

  13. Hepatoprotective activity of twelve novel 7'-hydroxy lignan glucosides from Arctii Fructus.

    PubMed

    Yang, Ya-Nan; Huang, Xiao-Ying; Feng, Zi-Ming; Jiang, Jian-Shuang; Zhang, Pei-Cheng

    2014-09-17

    Twelve novel 7'-hydroxy lignan glucosides (1-12), including two benzofuran-type neolignans, two 8-O-4' neolignans, two dibenzylbutyrolactone lignans, and six tetrahydrofuranoid lignans, together with six known lignan glucosides (13-18), were isolated from the fruit of Arctium lappa L. (Asteraceae), commonly known as Arctii Fructus. Their structures were elucidated using spectroscopy (1D and 2D NMR, MS, IR, ORD, and UV) and on the basis of chemical evidence. The absolute configurations of compounds 1-12 were confirmed using rotating frame nuclear overhauser effect spectroscopy (ROESY), the circular dichroic (CD) exciton chirality method, and Rh2(OCOCF3)4-induced CD spectrum analysis. All of the isolated compounds were tested for hepatoprotective effects against D-galactosamine-induced cytotoxicity in HL-7702 hepatic cells. Compounds 1, 2, 7-12, and 17 showed significantly stronger hepatoprotective activity than the positive control bicyclol at a concentration of 1 × 10(-5) M.

  14. Hepatoprotective activity of twelve novel 7'-hydroxy lignan glucosides from Arctii Fructus.

    PubMed

    Yang, Ya-Nan; Huang, Xiao-Ying; Feng, Zi-Ming; Jiang, Jian-Shuang; Zhang, Pei-Cheng

    2014-09-17

    Twelve novel 7'-hydroxy lignan glucosides (1-12), including two benzofuran-type neolignans, two 8-O-4' neolignans, two dibenzylbutyrolactone lignans, and six tetrahydrofuranoid lignans, together with six known lignan glucosides (13-18), were isolated from the fruit of Arctium lappa L. (Asteraceae), commonly known as Arctii Fructus. Their structures were elucidated using spectroscopy (1D and 2D NMR, MS, IR, ORD, and UV) and on the basis of chemical evidence. The absolute configurations of compounds 1-12 were confirmed using rotating frame nuclear overhauser effect spectroscopy (ROESY), the circular dichroic (CD) exciton chirality method, and Rh2(OCOCF3)4-induced CD spectrum analysis. All of the isolated compounds were tested for hepatoprotective effects against D-galactosamine-induced cytotoxicity in HL-7702 hepatic cells. Compounds 1, 2, 7-12, and 17 showed significantly stronger hepatoprotective activity than the positive control bicyclol at a concentration of 1 × 10(-5) M. PMID:25180661

  15. [Energy saving and LED lamp lighting and human health].

    PubMed

    Deĭnego, V N; Kaptsov, V A

    2013-01-01

    The appearance of new sources of high-intensity with large proportion of blue light in the spectrum revealed new risks of their influence on the function of the eye and human health, especially for children and teenagers. There is an urgent need to reconsider the research methods of vision hygiene in conditions of energy-saving and LED bulbs lighting. On the basis of a systematic approach and knowledge of the newly discovered photosensitive receptors there was built hierarchical model of the interaction of "light environment - the eye - the system of formation of visual images - the hormonal system of the person - his psycho-physiological state." This approach allowed us to develop a range of risk for the negative impact of spectrum on the functions of the eye and human health, as well as to formulate the hygiene requirements for energy-efficient high-intensity light sources.

  16. Energetic and Ecological Analysis of Energy Saving and Passive Houses

    NASA Astrophysics Data System (ADS)

    Sanytsky, Myroslav; Sekret, Robert; Wojcikiewicz, Mariusz

    2012-06-01

    In this paper results of influence of building-installation system parameters on value of energetic coefficients were calculated. Three types of buildings (standard, energy saving and low energy) with heating surface of 100, 150 i 200 m2 were used. The above types of buildings differ on thermal barrier and heating system efficiency. The influence of the gravity and mechanical ventilation systems on the final heat energy of different kinds of houses was shown. Parameters of the certificate for energy characteristics of building were used. Mathematics models of influence of thermal barrier parameters and heating surface on the value of energy characteristics, namely final energy EF, primary energy EP and useful energy EU were established. Influence of such parameters as heating energy factors, ventilation system and energy sources on the energy efficiency improvement of buildings was analyzed. The building environmental assessment system was proposed on the base of energetic and ecological analysis of houses.

  17. Considerations for Emerging Markets for Energy Savings Certificates

    SciTech Connect

    Friedman, B.; Bird, L.; Barbose, G.

    2008-10-01

    Early experiences with energy savings certificates (ESCs) have revealed both their merit and the challenges associated with them. In the United States, there has been little activity to date, so any lessons must be drawn from experiences in Italy, the United Kingdom (UK), France, and elsewhere. The staying power of European examples, particularly in Italy, demonstrates that ESCs can help initiate more efficiency projects. Although a robust market for renewable energy certificates (RECs) has emerged in both the voluntary and policy compliance contexts in the United States, ESCs have yet to gain significant traction. This report looks at the opportunity presented by ESCs, the unique challenges they bring, a comparison with RECs that can inform expectations about ESC market development, and the solutions and best practices early ESC market experience have demonstrated. It also examines whether there are real market barriers that have kept ESCs from being adopted and what structural features are necessary to develop effective trading programs.

  18. Energy Savings Certificate Markets: Opportunities and Implementation Barriers

    SciTech Connect

    Friedman, B.; Bird, L.; Barbose, G.

    2009-07-01

    Early experiences with energy savings certificates (ESCs) have revealed their merits and the challenges associated with them. While in the United States ESC markets have yet to gain significant traction, lessons can be drawn from early experiences in the states of Connecticut and New York, as well as from established markets in Italy, France, and elsewhere. The staying power of European examples demonstrates that ESCs can help initiate more efficiency projects. This article compares ESCs with renewable energy certificates (RECs), looks at the unique opportunities and challenges they present, and reviews solutions and best practices demonstrated by early ESC markets. Three major potential ESC market types are also reviewed: compliance, voluntary, and carbon. Additionally, factors that will benefit ESC markets in the United States are examined: new state EEPS policies, public interest in tools to mitigate climate change, and the growing interest in a voluntary market for ESCs.

  19. Potential for energy savings in old and new auto engines

    NASA Astrophysics Data System (ADS)

    Reitz, John R.

    1985-11-01

    This paper disucsses the potential for energy savings in the transportation sector through the use of both improved and entirely new automotive engines. Although spark-ignition and diesel internal combustion engines will remain the dominant choices for passenger-car use throughout the rest of this century, improved versions of these engines (lean-burn, low-friction spark-ignition and adiabatic, low-friction diesel engines) could, in the long term, provide a 20-30 percent improvement in fuel economy over what is currently available. The use of new materials, and modifications to both vehicle structure and vehicle transmissions may yield further improvements. Over a longer time frame, the introduction of the high-temperature gas-turbine engine and the use of new synfuels may provide further opportunities for energy conservation.

  20. Hepatoprotective activity of kadhaka kadhiradi kashayam.

    PubMed

    Sundari, S K; Valarmaathi, R; Akilandeswari, S; Begum, T N; Rafiullah, M R

    2000-01-01

    Kadhaka Kadhiradi Kasayam (KKK) was screened for hepatoprotective activity against carbon tetrachloride induced liver injury in albino rats at a dose of 0.5ml/kg body weight. The drug reduced weight alkaline phosphatase and GOT activity in liver, cholesterol and GPT activity in serum. There was no effect on protein and liver glycogen.

  1. Hepatoprotective and antioxidant activities of the aqueous extract from the rhizome of Phragmites australis.

    PubMed

    Chen, Song; Ju, Minli; Luo, Yin; Chen, Zhongjian; Zhao, Changpo; Zhou, Yang; Fu, Jie

    2013-01-01

    The rhizome of Phragmites australis has long been used for the treatment of hepatitis in traditional Chinese medicine. In this study, the hepatoprotective and antioxidant activities of an aqueous extract from the rhizome of P. australis (AE-PA) were evaluated. The acute toxicity test in mice showed that AE-PA was nontoxic since a dose of 2000 mg/kg body weight (b.w.) did not cause toxic symptoms or mortality. The prolongation of hexobarbital-induced sleeping time by carbon tetrachloride (CCl4) administration to mice was significantly reduced after pretreatment with AE-PA at 500 mg/kg b.w., proving the protective effect of the extract on microsomal drug-metabolizing enzyme. The oral administration of AE-PA to rats for 5 days before CCl4 intoxication caused a significant decrease in the CCl4-induced elevation of hepatic enzymes activities in serum, such as aspartate aminotransferase, alanine aminotransferase, and lactic acid dehydrogenase. This suggested that AE-PA had good hepatoprotective activity against CCl4-induced liver injury, which was confirmed by pathomorphological examination of the liver. Through evaluation of hydroxyl radical and superoxide anion radical scavenging activities, respectively, it was demonstrated that AE-PA had good antioxidant activity, which possibly contributed to its hepatoprotective activity. More research is needed to study the bio-active compounds in P. australis and to identify the potential hepatoprotective and antioxidant agents.

  2. A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine

    PubMed Central

    Al-Asmari, Abdulrahman K.; Al-Elaiwi, Abdulrahman M.; Athar, Md Tanwir; Tariq, Mohammad; Al Eid, Ahmed; Al-Asmary, Saeed M.

    2014-01-01

    Liver disease is one of the major causes of morbidity and mortality across the world. According to WHO estimates, about 500 million people are living with chronic hepatitis infections resulting in the death of over one million people annually. Medicinal plants serve as a vital source of potentially useful new compounds for the development of effective therapy to combat liver problems. Moreover herbal products have the advantage of better affordability and acceptability, better compatibility with the human body, and minimal side effects and is easier to store. In this review attempt has been made to summarize the scientific data published on hepatoprotective plants used in Saudi Arabian traditional medicine. The information includes medicinal uses of the plants, distribution in Saudi Arabia, ethnopharmacological profile, possible mechanism of action, chemical constituents, and toxicity data. Comprehensive scientific studies on safety and efficacy of these plants can revitalise the treatment of liver diseases. PMID:25587347

  3. A New Octadecenoic Acid Derivative from Caesalpinia gilliesii Flowers with Potent Hepatoprotective Activity

    PubMed Central

    Osman, Samir M.; El-Haddad, Alaadin E.; El-Raey, Mohamed A.; Abd El-Khalik, Soad M.; Koheil, Mahmoud A.; Wink, Michael

    2016-01-01

    Background: Caesalpinia gilliesii Hook is an ornamental shrub with showy yellow flowers. It was used in folk medicine due to its contents of different classes of secondary metabolites. In our previous study, dichloromethane extract of C. gilliesii flowers showed a good antioxidant activity. Aim of the Study: Isolation and identification of bioactive hepatoprotective compounds from C. gilliesii flowers dichloromethane fraction. Materials and Methods: The hepatoprotective activity of dichloromethane fraction and isolated compounds were studied in CCl4-intoxicated rat liver slices by measuring liver injury markers (alanine aminotransferase, aspartate aminotransferase and glutathione [GSH]). All compounds were structurally elucidated on the basis of electron ionization-mass spectrometry, one- and two-dimensional nuclear magnetic resonance. Results: A new 12,13,16-trihydroxy-14(Z)-octadecenoic acid was identified in addition to the known β-sitosterol-3-O-butyl, daucosterol, isorhamnetin, isorhamnetin-3-O-rhamnoside, luteolin-7,4’-dimethyl ether, genistein-5-methyl ether, luteolin-7-O-rhamnoside, isovanillic acid, and p-methoxybenzoic acid. Dichloromethane fraction and isorhamnetin were able to significantly protect the liver against intoxication. Moreover, the dichloromethane fraction and the isolated phytosterols induced GSH above the normal level. Conclusion: The hepatoprotective activity of C. gilliesii may be attributed to its high content of phytosterols and phenolic compounds. SUMMARY Bioactive Hepatoprotective phytosterols and phenolics from chloroform extract of Caesalpinia gilliesii Abbreviations used: ALT: Alanine Aminotransferase; AST: Aspartate aminotransferase; GSH: Glutathione; SC50: Scavenging Capacity 50 (SC 50); COSY: Correlation spectroscopy; NMR: Nuclear Magnetic Resonance; CC: Column chromatography; EI-MS: Electron-impact mass spectrometry; HSQC: Heteronuclear single-quantum correlation. PMID:27563221

  4. Resonance versus aerodynamics for energy savings in agile natural flyers

    NASA Astrophysics Data System (ADS)

    Kok, Jia M.; Chahl, Javaan

    2014-03-01

    Insects are the most diverse natural flyers in nature, being able to hover and perform agile manoeuvres. Dragon- flies in particular are aggressive flyers, attaining accelerations of up to 4g. Flight in all insects requires demanding aerodynamic and inertial loads be overcome. It has been proposed that resonance is a primary mechanism for reducing energy costs associated with flapping flight, by storing energy in an elastic thorax and releasing it on the following half-stroke. Certainly in insect flight motors dominated by inertial loads, such a mechanism would be extremely beneficial. However in highly manoeuvrable, aerodynamically dominated flyers, such as the dragonfly, the use of elastic storage members requires further investigation. We show that employing resonant mechanisms in a real world configuration produces minimal energy savings that are further reduced by 50 to 133% across the operational flapping frequency band of the dragonfly. Using a simple harmonic oscillator analysis to represent the dynamics of a dragonfly, we further demonstrate a reduction in manoeuvring limits of ˜1.5 times for a system employing elastic mechanisms. This is in contrast to the potential power reductions of √2/2 from regulating aerodynamics via active wing articulation. Aerodynamic means of energy storage provides flexibility between an energy efficient hover state and a manoeuvrable state capable of large accelerations. We conclude that active wing articulation is preferable to resonance for aerodynamically dominated natural flyers.

  5. Comparison of software models for energy savings from cool roofs

    SciTech Connect

    New, Joshua; Miller, William A.; Huang, Yu; Levinson, Ronnen

    2015-06-07

    For this study, a web-based Roof Savings Calculator (RSC) has been deployed for the United States Department of Energy as an industry-consensus tool to help building owners, manufacturers, distributors, contractors and researchers easily run complex roof and attic simulations. RSC simulates multiple roof and attic technologies for side-by-side comparison including reflective roofs, different roof slopes, above sheathing ventilation, radiant barriers, low-emittance roof surfaces, duct location, duct leakage rates, multiple substrate types, and insulation levels. Annual simulations of hour-by-hour, whole-building performance are used to provide estimated annual energy and cost savings from reduced HVAC use. While RSC reported similar cooling savings to other simulation engines, heating penalty varied significantly. RSC results show reduced cool roofing cost-effectiveness, thus mitigating expected economic incentives for this countermeasure to the urban heat island effect. This paper consolidates comparison of RSC's projected energy savings to other simulation engines including DOE-2.1E, AtticSim, Micropas, and EnergyPlus. Also included are comparisons to previous simulation-based studies, analysis of RSC cooling savings and heating penalties, the role of radiative heat exchange in an attic assembly, and changes made for increased accuracy of the duct model. Finally, radiant heat transfer and duct interaction not previously modeled is considered a major contributor to heating penalties.

  6. Blower upkeep, energy savings estimated at $20,000/yr

    SciTech Connect

    Diehl, R.; Powers, J.

    1987-05-01

    Vinyl chloride gas must be removed from operating vessels in a polymerization process at Occidental Chemical, Addis, LA. If left intact, the gases can polymerize and form deposits. Considered for this function were reciprocating and liquid ring type compressors. They were rejected, however, because of anticipated high valve maintenance and energy consumption. Since high reliability and leak-free performance are essential, two double-mechanical-sealed, positive displacement blowers were installed with water injection in 1980. The blowers are designed for those special applications where gas leak tightness is required or where continuous, high-pressure or vacuum, single-stage or two-stage is needed. The lobe-type blowers were selected by Occidental because they were considered to be best suited for the low-pressure differential operation. All internal surfaces are specially cleaned to reduce contamination and may be operated with non-hydrocarbon lubricants. A back-up seal on the drive shaft provides protection against leakage of process gas to the atmosphere. Maintenance and energy savings are estimated at $20,000/yr. The blowers were used with the water injection technique because previous experience vinyl chloride monomer indicated that there were major deposits inside the compressors and ring units. The blowers have provided contaminant-free (oil-free) monomer, and the water injection has prevented the polymerization material from sticking to the surfaces of the blowers. This has ensured practically trouble-free operation, and has greatly reduced maintenance and operation downtime, significantly reducing cost.

  7. Comparison of software models for energy savings from cool roofs

    DOE PAGESBeta

    New, Joshua; Miller, William A.; Huang, Yu; Levinson, Ronnen

    2015-06-07

    For this study, a web-based Roof Savings Calculator (RSC) has been deployed for the United States Department of Energy as an industry-consensus tool to help building owners, manufacturers, distributors, contractors and researchers easily run complex roof and attic simulations. RSC simulates multiple roof and attic technologies for side-by-side comparison including reflective roofs, different roof slopes, above sheathing ventilation, radiant barriers, low-emittance roof surfaces, duct location, duct leakage rates, multiple substrate types, and insulation levels. Annual simulations of hour-by-hour, whole-building performance are used to provide estimated annual energy and cost savings from reduced HVAC use. While RSC reported similar cooling savingsmore » to other simulation engines, heating penalty varied significantly. RSC results show reduced cool roofing cost-effectiveness, thus mitigating expected economic incentives for this countermeasure to the urban heat island effect. This paper consolidates comparison of RSC's projected energy savings to other simulation engines including DOE-2.1E, AtticSim, Micropas, and EnergyPlus. Also included are comparisons to previous simulation-based studies, analysis of RSC cooling savings and heating penalties, the role of radiative heat exchange in an attic assembly, and changes made for increased accuracy of the duct model. Finally, radiant heat transfer and duct interaction not previously modeled is considered a major contributor to heating penalties.« less

  8. Carbon and energy saving markets in compressed air

    NASA Astrophysics Data System (ADS)

    Cipollone, R.

    2015-08-01

    CO2 reduction and fossil fuel saving represent two of the cornerstones of the environmental commitments of all the countries of the world. The first engagement is of a medium to long term type, and unequivocally calls for a new energetic era. The second delays in time the fossil fuel technologies to favour an energetic transition. In order to sustain the two efforts, new immaterial markets have been established in almost all the countries of the world, whose exchanges (purchases and sales) concern CO2 emissions and equivalent fossil fuels that have not been emitted or burned. This paper goes deep inside two aspects not yet exploited: specific CO2 emissions and equivalent fossil fuel burned, as a function of compressed air produced. Reference is made to the current compressor technology, carefully analysing CAGI's (Compressed Air Gas Institute) data and integrating it with the PNUEROP (European Association of manufacturers of compressors, vacuum pumps, pneumatic tools and allied equipment) contribution on the compressor European market. On the base of energy saving estimates that could be put in place, this article also estimates the financial value of the CO2 emissions and fossil fuels avoided.

  9. Electric energy saving two position combination switching device

    SciTech Connect

    Andrews, P.

    1985-10-22

    In one form of the present preferred embodiment of the present invention it relates to a two-position feed-thru electric line cord piercing switching combination, of the rotary and even the rocker type, which saves electric energy by use of a half-wave diode rectifying means. The electric energy saving, two-position, combination switching means having only two electrical passing switching positions and thereby having no electrical ''off'' position. The switch will alternatingly provide either an electrical half-wave ''dim'' or an electrical full-wave ''on'' illumination to a single filament lamp, string of Christmas tree lamps and the like, and will even provide eight separate combinations, of one OFF abd three separate illuminations, when electrically connected ahead of a, for example, conventional LEVITON rotary 4-position lamp socket switching means which uses a conventional 3-way incandescent lamp member which is removable inserted into the lamp socket portion thereof. MICRO, CHERRY, toggle, rocker, push-button and the like, line cord non-piercing two-position switches may be used in other forms of the combination switching device or invention. The half-wave diode rectifying means is electrically connected shuntingly between and/or across substantially to two electrical contact members of the conductor wire-piercing and the wire non-piercing type of switching means. This construction results in automatic elimination of the electrical ''off'' position for generally any type 2 2-position ''off'' and ''on'' switching means.

  10. Energy Saving Glass Lamination via Selective Radio Frequency Heating

    SciTech Connect

    Shawn M. Allan; Patricia M. Strickland; Holly S. Shulman

    2009-11-11

    Ceralink Inc. developed FastFuse™, a rapid, new, energy saving process for lamination of glass and composites using radio frequency (RF) heating technology. The Inventions and Innovations program supported the technical and commercial research and development needed to elevate the innovation from bench scale to a self-supporting technology with significant potential for growth. The attached report provides an overview of the technical and commerical progress achieved for FastFuse™ during the course of the project. FastFuse™ has the potential to revolutionize the laminate manufacturing industries by replacing energy intensive, multi-step processes with an energy efficient, single-step process that allows higher throughput. FastFuse™ transmits RF energy directly into the interlayer to generate heat, eliminating the need to directly heat glass layers and the surrounding enclosures, such as autoclaves or vacuum systems. FastFuse™ offers lower start-up and energy costs (up to 90% or more reduction in energy costs), and faster cycles times (less than 5 minutes). FastFuse™ is compatible with EVA, TPU, and PVB interlayers, and has been demonstrated for glass, plastics, and multi-material structures such as photovoltaics and transparent armor.

  11. Facilitating Energy Savings through Enhanced Usability of Thermostats

    SciTech Connect

    Meier, Alan; Aragon, Cecilia; Peffer, Therese; Perry, Daniel; Pritoni, Marco

    2011-05-23

    Residential thermostats play a key role in controlling heating and cooling systems. Occupants often find the controls of programmable thermostats confusing, sometimes leading to higher heating consumption than when the buildings are controlled manually. A high degree of usability is vital to a programmable thermostat's effectiveness because, unlike a more efficient heating system, occupants must engage in specific actions after installation to obtain energy savings. We developed a procedure for measuring the usability of thermostats and tested this methodology with 31 subjects on five thermostats. The procedure requires first identifying representative tasks associated with the device and then testing the subjects ability to accomplish those tasks. The procedure was able to demonstrate the subjects wide ability to accomplish tasks and the influence of a device's usability on success rates. A metric based on the time to accomplish the tasks and the fraction of subjects actually completing the tasks captured the key aspects of each thermostat's usability. The procedure was recently adopted by the Energy Star Program for its thermostat specification. The approach appears suitable for quantifying usability of controls in other products, such as heat pump water heaters and commercial lighting.

  12. Calibrated energy simulations of potential energy savings in actual retail buildings

    NASA Astrophysics Data System (ADS)

    Alhafi, Zuhaira

    Retail stores are commercial buildings with high energy consumption due to their typically large volumes and long hours of operation. This dissertation assesses heating, ventilating and air conditioning saving strategies based on energy simulations with input parameters from actual retail buildings. The dissertation hypothesis is that "Retail store buildings will save a significant amount of energy by (1) modifying ventilation rates, and/or (2) resetting set point temperatures. These strategies have shown to be beneficial in previous studies. As presented in the literature review, potential energy savings ranged from 0.5% to 30% without compromising indoor thermal comfort and indoor air quality. The retail store buildings can be ventilated at rates significantly lower than rates called for in the ASHRAE Standard 62.1-2010 while maintaining acceptable indoor air quality. Therefore, two dissertation objectives are addressed: (1) Investigate opportunities to reduce ventilation rates that do not compromise indoor air quality in retail stores located in Central Pennsylvania, (2) Investigate opportunities to increase (in summer) and decrease (in winter) set point temperatures that do not compromise thermal comfort. This study conducted experimental measurements of ventilation rates required to maintain acceptable air quality and indoor environmental conditions requirements for two retail stores using ASHRAE Standard 62.1_2012. More specifically, among other parameters, occupancy density, indoor and outdoor pollutant concentrations, and indoor temperatures were measured continuously for one week interval. One of these retail stores were tested four times for a yearlong time period. Pollutants monitored were formaldehyde, carbon dioxide, particle size distributions and concentrations, as well as total volatile organic compounds. As a part of the base protocol, the number of occupants in each store was hourly counted during the test, and the results reveal that the occupant

  13. Demonstration of energy savings of cool roofs. Executive summary

    SciTech Connect

    Konopacki, S.; Gartland, L.; Akbari, H.; Rainer, L.

    1998-06-01

    The use of dark roofs affects cooling and heating energy use in buildings and the urban climate. At the building scale, dark roofs are heated by the summer sun and thus raise the summertime air-conditioning (a/c) demand. For highly-absorptive (low-albedo) roofs the difference between the surface and ambient air temperatures may be as high as 90 F on a summer afternoon. While for less absorptive (high-albedo) surfaces with similar insulative properties, such as roofs covered with a white coating, the difference is only about 20 F. For this reason, cool roofs (which absorb little insolation) can be effective in reducing cooling energy use. Earlier studies have suggested that cool roofs incur no additional cost if color changes are incorporated into routine re-roofing and re-surfacing schedules. There is a sizable body of measured data (primarily collected for residential sector) documenting energy-saving effects of cool roofs as shown. Both measured data and simulations clearly demonstrate that increasing the albedo of roofs is an attractive (and cost-effective) way of reducing the net radiative heat gains through the roof and hence, reducing building cooling loads. To change the albedo, the rooftops of buildings may be painted with reflective coatings or covered with a new light-colored material. Since most roofs have regular maintenance schedules or need to be re-roofed or re-coated periodically, the change of the albedo should be done then. In that case, the cost would be limited to the incremental cost associated with the high-albedo material. In buildings and climates with significant air-conditioning use, increasing the albedo of roofs will reduce energy use and produce a stream of savings immediately.

  14. CONTROLITE 1.0. Lighting Control Energy Savings

    SciTech Connect

    Rubinstein, F.

    1985-11-01

    CONTROLITE 1.0 is a lighting energy analysis program designed to calculate the energy savings and cost benefits obtainable using lighting controls in buildings. The program can compute the lighting energy reductions that result from using daylighting, scheduling, and other control strategies. When modeling daylight control systems, the program uses QUICKLITE to compute the daylight illuminances at specified points 5 times a day, 12 days a year (the 21st of each month), and for two sky conditions (clear and overcast skies). Fourier series techniques are used to fit a continuous curve through the computed illuminance points. The energy use for each of the 12 days is then computed given user-specified power-in/light-out characteristics of the modeled control system. The monthly and annual energy usage for overcast and clear conditions are found separately by fitting two long-term Fourier series curves to the energy use computed for each of the 12 days. Finally, the monthly energy use is calculated by taking a weighted average for the monthly energy use computed for the overcast and clear sky conditions. The program only treats the energy use directly attributable to lighting. The impact of lighting control strategies on building thermal loads is not computed. The program allows input of different control schedules (i.e., on/off times for the lighting system) for each day of the week, but every week of the year is treated the same; thus, holidays cannot be modeled explicitly. When used for daylighting purposes, CONTROLITE1.0 understands only clear and overcast conditions. User-supplied values for the proportion of clear and overcast hours for each month of the year are required to accommodate different climatic conditions.

  15. Comparison of Software Models for Energy Savings from Cool Roofs

    SciTech Connect

    New, Joshua Ryan; Miller, William A; Huang, Yu; Levinson, Ronnen

    2014-01-01

    A web-based Roof Savings Calculator (RSC) has been deployed for the United States Department of Energy as an industry-consensus tool to help building owners, manufacturers, distributors, contractors and researchers easily run complex roof and attic simulations. This tool employs modern web technologies, usability design, and national average defaults as an interface to annual simulations of hour-by-hour, whole-building performance using the world-class simulation tools DOE-2.1E and AtticSim in order to provide estimated annual energy and cost savings. In addition to cool reflective roofs, RSC simulates multiple roof and attic configurations including different roof slopes, above sheathing ventilation, radiant barriers, low-emittance roof surfaces, duct location, duct leakage rates, multiple substrate types, and insulation levels. A base case and energy-efficient alternative can be compared side-by-side to estimate monthly energy. RSC was benchmarked against field data from demonstration homes in Ft. Irwin, California; while cooling savings were similar, heating penalty varied significantly across different simulation engines. RSC results reduce cool roofing cost-effectiveness thus mitigating expected economic incentives for this countermeasure to the urban heat island effect. This paper consolidates comparison of RSC s projected energy savings to other simulation engines including DOE-2.1E, AtticSim, Micropas, and EnergyPlus, and presents preliminary analyses. RSC s algorithms for capturing radiant heat transfer and duct interaction in the attic assembly are considered major contributing factors to increased cooling savings and heating penalties. Comparison to previous simulation-based studies, analysis on the force multiplier of RSC cooling savings and heating penalties, the role of radiative heat exchange in an attic assembly, and changes made for increased accuracy of the duct model are included.

  16. Analysis of energy saving lamps for use by photosensitive individuals.

    PubMed

    Fenton, L; Ferguson, J; Moseley, H

    2012-08-01

    Due to European legislation, the British government has begun the phase out of incandescent bulbs, to be replaced by energy-saving alternatives. The alternatives that are available on the market are Compact Fluorescent Lamps (CFL), Energy-Efficient Halogens (EEH) and Light Emitting Diodes (LED). Whilst previous research has shown that CFLs emit UVC, UVB and UVA, there is conflicting data available on whether double enveloped CFLs are a safer alternative to single enveloped CFLs for individuals suffering from photosensitivity. The emission spectra of 106 single enveloped CFLs and 65 double enveloped CFLs were measured. There were 17 different models of single enveloped CFLs, including lamps from 6 different manufacturers (ranging from 8-20 W) and 9 models of double enveloped CFLs from 6 different manufacturers (7-15 W). In addition, the emission spectra of 53 LEDs and 56 EEHs were also analysed. The LEDs consisted of 8 different models, from 3 manufacturers, spanning between 2.5 and 12 W. There were 11 models of EEH from 6 different manufacturers with wattages ranging from 28-70 W. In order to reduce sample bias, some bulbs were provided by the lighting industry federation and others were purchased randomly from local retailers. The results validate previous research in that considerable variation exists in the UV emitted from CFLs. This variation in UV levels is true, not only within different makes and models but also, surprisingly, within a box of 8 seemingly identical bulbs supplied by a single manufacturer. It was concluded that double enveloped CFLs do reduce the levels of UVC and UVB and therefore are a safer alternative for photosensitive individuals. However, as some double enveloped CFLs and EEHs do emit UVA at levels that provoke a reaction in the skin of UVA sensitive individuals, newly emerging LEDs that have minimal UV levels may provide a safer alternative.

  17. Investigation of the Antioxidant and Hepatoprotective Potential of Hypericum mysorense

    PubMed Central

    Hariharapura, Raghu C.; Srinivasan, Ramamurthy; Ashok, Godavarthi; Dongre, Santoshkumar H.; Jagani, Hitesh V.; Vijayan, Pottekkad

    2014-01-01

    Background: Hypericum is a well-known plant genus in herbal medicine. Hypericum mysorense (Family: Hypericaceae), a plant belonging to the same genus, is well known in folklore medicine for its varied therapeutic potential. Objective: The aim of the present study was to investigate the different parts of the plant for antioxidant and hepatoprotective properties. Materials and Methods: The methanol extracts of Hypericum mysorense prepared from various parts of the plant were tested in vitro for their free radical scavenging activity against ABTS• (diammonium salt), DPPH• (1,1-diphenyl-2-picrylhydrazyl), NO•, O2•− and •OH radicals, using standard systems of assays. The total antioxidant capacity, total phenolic and total flavonoid content of the extracts were analyzed. Further, the leaf and flowering top extracts were tested for their in vivo antioxidant and hepatoprotective activities on Wistar rats using a carbon tetrachloride-induced hepatic injury model. Results: The leaf and flowering top extract showed potent antioxidant activity and also possessed highest total phenolic and flavonoid content. The antioxidant activity and the total phenolic and flavonoid content present in these extracts showed a good correlation. The leaf and flowering top extracts at 200 mg/kg restored aspartate amino transferase (ASAT), alanine amino transferase (ALAT), alkaline phosphatase (ALP), total bilirubin and protein levels significantly in CCl4-intoxicated rats. The tested extracts also showed a significant (p < 0.001) reduction in 2-thiobarbituric acid reactive substance (TBARS) levels with an increase in SOD and CAT levels. The histopathology of liver did not show any toxicity after the treatment with the extracts. The active extracts were standardized using two marker compounds, hyperoside and rutin, which were isolated from the plant by HPLC. HPLC studies revealed that the maximum concentration of hyperoside and rutin is present in the flowering top extract. PMID

  18. Application of Genetic Algorithm to the Design Optimization of Complex Energy Saving Glass Coating Structure

    NASA Astrophysics Data System (ADS)

    Johar, F. M.; Azmin, F. A.; Shibghatullah, A. S.; Suaidi, M. K.; Ahmad, B. H.; Abd Aziz, M. Z. A.; Salleh, S. N.; Shukor, M. Md

    2014-04-01

    Attenuation of GSM, GPS and personal communication signal leads to poor communication inside the building using regular shapes of energy saving glass coating. Thus, the transmission is very low. A brand new type of band pass frequency selective surface (FSS) for energy saving glass application is presented in this paper for one unit cell. Numerical Periodic Method of Moment approach according to a previous study has been applied to determine the new optimum design of one unit cell energy saving glass coating structure. Optimization technique based on the Genetic Algorithm (GA) is used to obtain an improved in return loss and transmission signal. The unit cell of FSS is designed and simulated using the CST Microwave Studio software at based on industrial, scientific and medical bands (ISM). A unique and irregular shape of an energy saving glass coating structure is obtained with lower return loss and improved transmission coefficient.

  19. Greater Energy Savings through Building Energy Performance Policy: Four Leading Policy and Program Options

    SciTech Connect

    SEE Action Existing Commercial Buildings Working Group

    2014-05-30

    This paper lays out recommendations for linking existing policies and developing new policies, such that their success is based on the real energy savings achieved in buildings. This approach has the potential to affect the entire building lifecycle.

  20. ESPC Overview: Cash Flows, Scenarios, and Associated Diagrams for Energy Savings Performance Contracts

    SciTech Connect

    Tetreault, T.; Regenthal, S.

    2011-05-01

    This document is meant to inform state and local decision makers about the process of energy savings performance contracts, and how projected savings and allocated energy-related budgets can be impacted by changes in utility prices.

  1. ESPC Overview. Cash Flows, Scenarios, and Associated Diagrams for Energy Savings Performance Contracts

    SciTech Connect

    Tetreault, T.; Regenthal, S.

    2011-05-01

    This document is meant to inform state and local decision makers about the process of energy savings performance contracts, and how projected savings and allocated energy-related budgets can be impacted by changes in utility prices.

  2. Alternative Energy Saving Technology Analysis Report for Richland High School Renovation Project

    SciTech Connect

    Liu, Bing

    2004-08-09

    On July 8, 2004, L&S Engineering, Inc. submitted a technical assistance request to Pacific Northwest National Laboratory (PNNL) to help estimate the potential energy savings and cost effectiveness of the solar energy and daylighting design alternatives for Richland High School Renovation Project in Richland, WA. L&S Engineering expected PNNL to evaluate the potential energy savings and energy cost savings, the probable installation costs, incentives or grants to reduce the installed costs and simple payback for the following alternative measures: (1) Daylighting in New Gym; (2) Solar Photovoltaics; (3) Solar Domestic Hot Water Pre-Heat; and (4) Solar Outside Air Pre-Heat Following are the findings of the energy savings and cost-effectiveness analysis of above alternative energy saving technologies.

  3. Saint-Gobain Shows the Way on Effectively Preparing for Energy Savings Assessments

    SciTech Connect

    2010-06-10

    Saint-Gobain developed an approach to help guide other companies on effectively preparing for an Energy Savings Assessment in a manner that will maximize its value and ensure implementation of efficiency improvement recommendations. Learn about Saint-Gobain's approach.

  4. Technical Support Document: 50% Energy Savings for Quick-Service Restaurants

    SciTech Connect

    Zhang, Jian; Schrock, D. W.; Fisher, D. R.; Livchak, A.; Zabrowski, D. A.; Athalye, Rahul A.; Liu, Bing

    2010-09-30

    Document describing PNNL's project to develop a package of energy efficiency measures that demonstrate the feasibility of achieving a 50% energy savings for quick-service restaurants with a simple payback of 5 years or less.

  5. Technical Support Document: Development of the Advanced Energy Design Guide for Grocery Stores--50% Energy Savings

    SciTech Connect

    Hale, E. T.; Macumber, D. L.; Long, N. L.; Griffith, B. T.; Benne, K. S.; Pless, S. D.; Torcellini, P. A.

    2008-09-01

    This report provides recommendations that architects, designers, contractors, developers, owners, and lessees of grocery store buildings can use to achieve whole-building energy savings of at least 50% over ASHRAE Standard 90.1-2004.

  6. K2 Urbancorp, LLC.: Hot, Humid Climate Region 40+% Energy Savings

    SciTech Connect

    2009-08-13

    This case study describes a community of historically inspired energy efficient homes that met the 40% whole-house source energy savings by focusing primarily on tightening the building envelope and sealing ductwork.

  7. Technical Support Document: 50% Energy Savings Design Technology Packages for Highway Lodging Buildings

    SciTech Connect

    Jiang, Wei; Gowri, Krishnan; Lane, Michael D.; Thornton, Brian A.; Rosenberg, Michael I.; Liu, Bing

    2009-09-28

    This Technical Support Document (TSD) describes the process, methodology and assumptions for development of the 50% Energy Savings Design Technology Packages for Highway Lodging Buildings, a design guidance document intended to provide recommendations for achieving 50% energy savings in highway lodging properties over the energy-efficiency levels contained in ANSI/ASHRAE/IESNA Standard 90.1-2004, Energy Standard for Buildings Except Low-Rise Residential Buildings.

  8. Persistence of energy savings: What do we know and how can it be ensured

    SciTech Connect

    Vine, E.

    1992-05-01

    This paper presents a conceptual framework for analyzing persistence of energy savings, summarizes the limited experience of what we know about persistence, provides guidance for conducting retrospective and prospective persistence studies, and suggests strategies for ensuring persistence. Because this area of research is in its infancy, unequivocal conclusions about persistence would be premature. Accordingly, this paper provides guidance for both conducting research in this area and developing policies and mechanisms to help ensure the persistence of energy savings.

  9. Persistence of energy savings: What do we know and how can it be ensured?

    SciTech Connect

    Vine, E.

    1992-05-01

    This paper presents a conceptual framework for analyzing persistence of energy savings, summarizes the limited experience of what we know about persistence, provides guidance for conducting retrospective and prospective persistence studies, and suggests strategies for ensuring persistence. Because this area of research is in its infancy, unequivocal conclusions about persistence would be premature. Accordingly, this paper provides guidance for both conducting research in this area and developing policies and mechanisms to help ensure the persistence of energy savings.

  10. An energy saving mechanism of EPON networks for real time video transmission

    NASA Astrophysics Data System (ADS)

    Liu, Chien-Ping; Wu, Ho-Ting; Chiang, Yun-Ting; Chien, Shieh-Chieh; Ke, Kai-Wei

    2015-07-01

    Modern access networks are constructed widely by passive optical networks (PONs) to meet the growing bandwidth demand. However, higher bandwidth means more energy consumption. To save energy, a few research works propose the dual-mode energy saving mechanism that allows the ONU to operate between active and sleep modes periodically. However, such dual-mode energy saving design may induce unnecessary power consumption or packet delay increase in the case where only downstream data exist for most of the time. In this paper, we propose a new tri-mode energy saving scheme for Ethernet PON (EPON). The new tri-mode energy saving design, combining the dual-mode saving mechanism with the doze mode, allows the ONU to switch among these three modes alternatively. In the doze mode, the ONU may receive downstream data while keeping its transmitter close. Such scenario is often observed for real time video downstream transmission. Furthermore, the low packet delay of high priority upstream data can be attained through the use of early wake-up mechanism employed in both energy saving modes. The energy saving and system efficiency can thus be achieved jointly while maintaining the differentiated QoS for data with various priorities. Performance results via simulation have demonstrated the effectiveness of such mechanism.

  11. Missouri Agricultural Energy Saving Team-A Revolutionary Opportunity (MAESTRO)

    SciTech Connect

    McIntosh, Jane; Schumacher, Leon

    2014-10-23

    The Missouri Agricultural Energy Saving Team-A Revolutionary Opportunity (MAESTRO) program brought together a team of representatives from government, academia, and private industry to enhance the availability of energy efficiency services for small livestock producers in the State of Missouri. The Missouri Department of Agriculture (MDA) managed the project via a subcontract with the University of Missouri (MU), College of Agriculture Food and Natural Resources, MU Extension, the MU College of Human Environmental Sciences, the MU College of Engineering, and the Missouri Agricultural and Small Business Development Authority (MASBDA). MU teamed with EnSave, Inc, a nationally-recognized expert in agricultural energy efficiency to assist with marketing, outreach, provision of farm energy audits and customer service. MU also teamed with independent home contractors to facilitate energy audits of the farm buildings and homes of these livestock producers. The goals of the project were to: (1) improve the environment by reducing fossil fuel emissions and reducing the total energy used on small animal farms; (2) stimulate the economy of local and regional communities by creating or retaining jobs; and (3) improve the profitability of Missouri livestock producers by reducing their energy expenditures. Historically, Missouri scientists/engineers conducted programs on energy use in agriculture, such as in equipment, grain handling and tillage practices. The MAESTRO program was the first to focus strictly on energy efficiency associated with livestock production systems in Missouri and to investigate the applicability and potential of addressing energy efficiency in animal production from a building efficiency perspective. A. Project Objectives The goal of the MAESTRO program was to strengthen the financial viability and environmental soundness of Missouri's small animal farms by helping them implement energy efficient technologies for the production facility, farm buildings

  12. Hepatoprotection of sesquiterpenoids: a quantitative structure-activity relationship (QSAR) approach.

    PubMed

    Vinholes, Juliana; Rudnitskaya, Alisa; Gonçalves, Pedro; Martel, Fátima; Coimbra, Manuel A; Rocha, Sílvia M

    2014-03-01

    The relative hepatoprotection effect of fifteen sesquiterpenoids, commonly found in plants and plant-derived foods and beverages was assessed. Endogenous lipid peroxidation (assay A) and induced lipid peroxidation (assay B) were evaluated in liver homogenates from Wistar rats by the thiobarbituric acid reactive species test. Sesquiterpenoids with different chemical structures were tested: trans,trans-farnesol, cis-nerolidol, (-)-α-bisabolol, trans-β-farnesene, germacrene D, α-humulene, β-caryophyllene, isocaryophyllene, (+)-valencene, guaiazulene, (-)-α-cedrene, (+)-aromadendrene, (-)-α-neoclovene, (-)-α-copaene, and (+)-cyclosativene. Ascorbic acid was used as a positive antioxidant control. With the exception of α-humulene, all the sesquiterpenoids under study (1mM) were effective in reducing the malonaldehyde levels in both endogenous and induced lipid peroxidation up to 35% and 70%, respectively. The 3D-QSAR models developed, relating the hepatoprotection activity with molecular properties, showed good fit (Radj(2) 0.819 and 0.972 for the assays A and B, respectively) with good prediction power (Q(2)>0.950 and SDEP<2%, for both models A and B). A network of effects associated with structural and chemical features of sesquiterpenoids such as shape, branching, symmetry, and presence of electronegative fragments, can modulate the hepatoprotective activity observed for these compounds.

  13. A Novel Sensor Platform Matching the Improved Version of IPMVP Option C for Measuring Energy Savings

    PubMed Central

    Tseng, Yen-Chieh; Lee, Da-Sheng; Lin, Cheng-Fang; Chang, Ching-Yuan

    2013-01-01

    It is easy to measure energy consumption with a power meter. However, energy savings cannot be directly computed by the powers measured using existing power meter technologies, since the power consumption only reflects parts of the real energy flows. The International Performance Measurement and Verification Protocol (IPMVP) was proposed by the Efficiency Valuation Organization (EVO) to quantify energy savings using four different methodologies of A, B, C and D. Although energy savings can be estimated following the IPMVP, there are limitations on its practical implementation. Moreover, the data processing methods of the four IPMVP alternatives use multiple sensors (thermometer, hygrometer, Occupant information) and power meter readings to simulate all facilities, in order to determine an energy usage benchmark and the energy savings. This study proposes a simple sensor platform to measure energy savings. Using usually the Electronic Product Code (EPC) global standard, an architecture framework for an information system is constructed that integrates sensors data, power meter readings and occupancy conditions. The proposed sensor platform is used to monitor a building with a newly built vertical garden system (VGS). A VGS shields solar radiation and saves on energy that would be expended on air-conditioning. With this platform, the amount of energy saved in the whole facility is measured and reported in real-time. The data are compared with those obtained from detailed measurement and verification (M&V) processes. The discrepancy is less than 1.565%. Using measurements from the proposed sensor platform, the energy savings for the entire facility are quantified, with a resolution of ±1.2%. The VGS gives an 8.483% daily electricity saving for the building. Thus, the results show that the simple sensor platform proposed by this study is more widely applicable than the four complicated IPMVP alternatives and the VGS is an effective tool in reducing the carbon

  14. A novel sensor platform matching the improved version of IPMVP option C for measuring energy savings.

    PubMed

    Tseng, Yen-Chieh; Lee, Da-Sheng; Lin, Cheng-Fang; Chang, Ching-Yuan

    2013-05-22

    It is easy to measure energy consumption with a power meter. However, energy savings cannot be directly computed by the powers measured using existing power meter technologies, since the power consumption only reflects parts of the real energy flows. The International Performance Measurement and Verification Protocol (IPMVP) was proposed by the Efficiency Valuation Organization (EVO) to quantify energy savings using four different methodologies of A, B, C and D. Although energy savings can be estimated following the IPMVP, there are limitations on its practical implementation. Moreover, the data processing methods of the four IPMVP alternatives use multiple sensors (thermometer, hygrometer, Occupant information) and power meter readings to simulate all facilities, in order to determine an energy usage benchmark and the energy savings. This study proposes a simple sensor platform to measure energy savings. Using usually the Electronic Product Code (EPC) global standard, an architecture framework for an information system is constructed that integrates sensors data, power meter readings and occupancy conditions. The proposed sensor platform is used to monitor a building with a newly built vertical garden system (VGS). A VGS shields solar radiation and saves on energy that would be expended on air-conditioning. With this platform, the amount of energy saved in the whole facility is measured and reported in real-time. The data are compared with those obtained from detailed measurement and verification (M&V) processes. The discrepancy is less than 1.565%. Using measurements from the proposed sensor platform, the energy savings for the entire facility are quantified, with a resolution of ±1.2%. The VGS gives an 8.483% daily electricity saving for the building. Thus, the results show that the simple sensor platform proposed by this study is more widely applicable than the four complicated IPMVP alternatives and the VGS is an effective tool in reducing the carbon

  15. Methods for assessing the energy-saving efficiency of industrial symbiosis in industrial parks.

    PubMed

    Li, Wenfeng; Cui, Zhaojie; Han, Feng

    2015-01-01

    The available energy resources are being depleted worldwide. Industrial symbiosis (IS) provides a promising approach for increasing the efficiency of energy utilization, with numerous studies reporting the superiority of this technology. However, studies quantifying the energy-saving efficiency of IS remain insufficient. This paper proposes an index system for the quantitative evaluation of the energy-saving efficiency of IS. Both energy-saving and financial indexes were selected, the former include the IS energy-saving index, the contribution rate of energy saved through IS, fractional energy savings, and cut rate of energy consumption per total output value; and the latter include the IS investment payback period, IS input-output ratio, net present value (NPV), and internal rate of return (IRR) of IS. The proposed methods were applied to a case study on the XF Industrial Park (XF IP), in the city of Liaocheng in Shandong Province of China. Three energy-saving channels using IS were found in the XF IP: (a) utilizing the energy of high-temperature materials among industrial processes, (b) recovering waste heat and steam between different processes, and (c) saving energy by sharing infrastructures. The results showed that the energy efficiency index of IS was 0.326, accounting for 34.6% of the comprehensive energy-saving index in 2011, and the fractional energy-savings were 12.42%. The index of energy consumption per total industrial output value varied from 90.9 tce/MRMB to 51.6 tce/MRMB. Thus, the cut rate of energy consumption per total industrial output value was 43.42%. The average values of the IS input-output ratio was 406.2 RMB/tce, 57.2% lower than the price of standard coal. Static investment payback period in the XF IP was 8.5 months, indicating that the XF IP began to earn profit 8.5 months after the construction of all IS modes. The NVP and IRR of each IS mode in the XF IP were greater than zero, with average values equal to 1,789.96 MRMB and 140

  16. Methods for assessing the energy-saving efficiency of industrial symbiosis in industrial parks.

    PubMed

    Li, Wenfeng; Cui, Zhaojie; Han, Feng

    2015-01-01

    The available energy resources are being depleted worldwide. Industrial symbiosis (IS) provides a promising approach for increasing the efficiency of energy utilization, with numerous studies reporting the superiority of this technology. However, studies quantifying the energy-saving efficiency of IS remain insufficient. This paper proposes an index system for the quantitative evaluation of the energy-saving efficiency of IS. Both energy-saving and financial indexes were selected, the former include the IS energy-saving index, the contribution rate of energy saved through IS, fractional energy savings, and cut rate of energy consumption per total output value; and the latter include the IS investment payback period, IS input-output ratio, net present value (NPV), and internal rate of return (IRR) of IS. The proposed methods were applied to a case study on the XF Industrial Park (XF IP), in the city of Liaocheng in Shandong Province of China. Three energy-saving channels using IS were found in the XF IP: (a) utilizing the energy of high-temperature materials among industrial processes, (b) recovering waste heat and steam between different processes, and (c) saving energy by sharing infrastructures. The results showed that the energy efficiency index of IS was 0.326, accounting for 34.6% of the comprehensive energy-saving index in 2011, and the fractional energy-savings were 12.42%. The index of energy consumption per total industrial output value varied from 90.9 tce/MRMB to 51.6 tce/MRMB. Thus, the cut rate of energy consumption per total industrial output value was 43.42%. The average values of the IS input-output ratio was 406.2 RMB/tce, 57.2% lower than the price of standard coal. Static investment payback period in the XF IP was 8.5 months, indicating that the XF IP began to earn profit 8.5 months after the construction of all IS modes. The NVP and IRR of each IS mode in the XF IP were greater than zero, with average values equal to 1,789.96 MRMB and 140

  17. Energy saving mechanisms, collective behavior and the variation range hypothesis in biological systems: A review.

    PubMed

    Trenchard, Hugh; Perc, Matjaž

    2016-09-01

    Energy saving mechanisms are ubiquitous in nature. Aerodynamic and hydrodynamic drafting, vortice uplift, Bernoulli suction, thermoregulatory coupling, path following, physical hooks, synchronization, and cooperation are only some of the better-known examples. While drafting mechanisms also appear in non-biological systems such as sedimentation and particle vortices, the broad spectrum of these mechanisms appears more diversely in biological systems that include bacteria, spermatozoa, various aquatic species, birds, land animals, semi-fluid dwellers like turtle hatchlings, as well as human systems. We present the thermodynamic framework for energy saving mechanisms, and we review evidence in favor of the variation range hypothesis. This hypothesis posits that, as an evolutionary process, the variation range between strongest and weakest group members converges on the equivalent energy saving quantity that is generated by the energy saving mechanism. We also review self-organized structures that emerge due to energy saving mechanisms, including convective processes that can be observed in many systems over both short and long time scales, as well as high collective output processes in which a form of collective position locking occurs.

  18. Energy saving mechanisms, collective behavior and the variation range hypothesis in biological systems: A review.

    PubMed

    Trenchard, Hugh; Perc, Matjaž

    2016-09-01

    Energy saving mechanisms are ubiquitous in nature. Aerodynamic and hydrodynamic drafting, vortice uplift, Bernoulli suction, thermoregulatory coupling, path following, physical hooks, synchronization, and cooperation are only some of the better-known examples. While drafting mechanisms also appear in non-biological systems such as sedimentation and particle vortices, the broad spectrum of these mechanisms appears more diversely in biological systems that include bacteria, spermatozoa, various aquatic species, birds, land animals, semi-fluid dwellers like turtle hatchlings, as well as human systems. We present the thermodynamic framework for energy saving mechanisms, and we review evidence in favor of the variation range hypothesis. This hypothesis posits that, as an evolutionary process, the variation range between strongest and weakest group members converges on the equivalent energy saving quantity that is generated by the energy saving mechanism. We also review self-organized structures that emerge due to energy saving mechanisms, including convective processes that can be observed in many systems over both short and long time scales, as well as high collective output processes in which a form of collective position locking occurs. PMID:27288936

  19. Antioxidant and hepatoprotective effect of aqueous extract of germinated and fermented mung bean on ethanol-mediated liver damage.

    PubMed

    Mohd Ali, Norlaily; Mohd Yusof, Hamidah; Long, Kamariah; Yeap, Swee Keong; Ho, Wan Yong; Beh, Boon Kee; Koh, Soo Peng; Abdullah, Mohd Puad; Alitheen, Noorjahan Banu

    2013-01-01

    Mung bean is a hepatoprotective agent in dietary supplements. Fermentation and germination processes are well recognized to enhance the nutritional values especially the concentration of active compounds such as amino acids and GABA of various foods. In this study, antioxidant and hepatoprotective effects of freeze-dried mung bean and amino-acid- and GABA-enriched germinated and fermented mung bean aqueous extracts were compared. Liver superoxide dismutase (SOD), malondialdehyde (MDA), ferric reducing antioxidant power (FRAP), nitric oxide (NO) levels, and serum biochemical profile such as aspartate transaminase (AST), alanine transaminase (ALT), triglycerides (TG), and cholesterol and histopathological changes were examined for the antioxidant and hepatoprotective effects of these treatments. Germinated and fermented mung bean have recorded an increase of 27.9 and 7.3 times of GABA and 8.7 and 13.2 times of amino acid improvement, respectively, as compared to normal mung bean. Besides, improvement of antioxidant levels, serum markers, and NO level associated with better histopathological evaluation indicated that these extracts could promote effective recovery from hepatocyte damage. These results suggested that freeze-dried, germinated, and fermented mung bean aqueous extracts enriched with amino acids and GABA possessed better hepatoprotective effect as compared to normal mung bean.

  20. Antioxidant and Hepatoprotective Effect of Aqueous Extract of Germinated and Fermented Mung Bean on Ethanol-Mediated Liver Damage

    PubMed Central

    Mohd Ali, Norlaily; Mohd Yusof, Hamidah; Long, Kamariah; Yeap, Swee Keong; Ho, Wan Yong; Beh, Boon Kee; Koh, Soo Peng; Abdullah, Mohd Puad; Alitheen, Noorjahan Banu

    2013-01-01

    Mung bean is a hepatoprotective agent in dietary supplements. Fermentation and germination processes are well recognized to enhance the nutritional values especially the concentration of active compounds such as amino acids and GABA of various foods. In this study, antioxidant and hepatoprotective effects of freeze-dried mung bean and amino-acid- and GABA-enriched germinated and fermented mung bean aqueous extracts were compared. Liver superoxide dismutase (SOD), malondialdehyde (MDA), ferric reducing antioxidant power (FRAP), nitric oxide (NO) levels, and serum biochemical profile such as aspartate transaminase (AST), alanine transaminase (ALT), triglycerides (TG), and cholesterol and histopathological changes were examined for the antioxidant and hepatoprotective effects of these treatments. Germinated and fermented mung bean have recorded an increase of 27.9 and 7.3 times of GABA and 8.7 and 13.2 times of amino acid improvement, respectively, as compared to normal mung bean. Besides, improvement of antioxidant levels, serum markers, and NO level associated with better histopathological evaluation indicated that these extracts could promote effective recovery from hepatocyte damage. These results suggested that freeze-dried, germinated, and fermented mung bean aqueous extracts enriched with amino acids and GABA possessed better hepatoprotective effect as compared to normal mung bean. PMID:23484140

  1. Bandwidth Study on Energy Use and Potential Energy Saving Opportunities in U.S. Iron and Steel Manufacturing

    SciTech Connect

    Keith Jamison, Caroline Kramer, Sabine Brueske, Aaron Fisher

    2015-06-01

    Energy bandwidth studies of U.S. manufacturing sectors can serve as foundational references in framing the range (or bandwidth) of potential energy savings opportunities. This bandwidth study examines energy consumption and potential energy savings opportunities in U.S. iron and steel manufacturing. The study relies on multiple sources to estimate the energy used in six individual process areas and select subareas, representing 82% of sector-wide energy consumption. Energy savings opportunities for individual processes and subareas are based on technologies currently in use or under development; the potential savings are then extrapolated to estimate sector-wide energy savings opportunity.

  2. Bandwidth Study on Energy Use and Potential Energy Saving Opportunities in U.S. Pulp and Paper Manufacturing

    SciTech Connect

    Sabine Brueske, Caroline Kramer, Aaron Fisher

    2015-06-01

    Energy bandwidth studies of U.S. manufacturing sectors can serve as foundational references in framing the range (or bandwidth) of potential energy savings opportunities. This bandwidth study examines energy consumption and potential energy savings opportunities in U.S. pulp and paper manufacturing. The study relies on multiple sources to estimate the energy used in six individual process areas, representing 52% of sector-wide energy consumption. Energy savings opportunities for individual processes are based on technologies currently in use or under development; the potential savings are then extrapolated to estimate sector-wide energy savings opportunity

  3. Study of State Energy Conservation Program: 1979 energy savings indicators. [Estimated Btu's and dollars

    SciTech Connect

    1980-06-01

    This study reviewed 1979 energy savings reports provided by states for conservation measures in four major categories of State Energy Conservation Program services, namely: (1) industrial, commercial, and institutional; (2) residential; (3) thermal and lighting; and (4) transportation. Conservation measures in these categories constitute a major portion of the total estimated 1980 savings for the State Energy Conservation Program. This study only addressed measures in these categories for which usable documentation had been submitted by states. Based on a review of measures supported by available documentation, the study estimates that energy savings associated with the conservation measures reviewed were 108 TBtu's for the calendar year 1979. These estimated energy savings for 1979 were converted into 540 million dollars for 1979 and 2.8 billion dollars over the projected life of the conservation measures.

  4. Energy savings from repair of uncontrolled airflow in 18 small commercial buildings

    SciTech Connect

    Withers, C.R. Jr.; Cummings, J.B.; Fairey, P.W.; McKendry, B.B.; Moyer, N.A.

    1996-12-31

    Uncontrolled airflow, including duct leakage, pressure imbalances caused by closed interior doors, and exhaust/intake airflow imbalance, was characterized in 70 commercial buildings. In 18 of these buildings, uncontrolled airflows were repaired and energy savings from these repairs were monitored. In most buildings, the retrofit was duct repair. In other cases, outdoor airflow was reduced and return air transfers were provided. Cooling energy use was reduced by an average 15.1% in these 18 buildings. With an average repair cost of $455 and average cooling energy savings of $195 per year, uncontrolled airflow retrofits proved to be very cost-effective. Various factors indicate that greater energy savings could be achieved in the future.

  5. Modeling energy savings from urban shade trees: an assessment of the CITYgreen energy conservation module.

    PubMed

    Carver, Andrew D; Unger, Daniel R; Parks, Courtney L

    2004-11-01

    CITYgreen software has become a commonly used tool to quantify the benefits of urban shade trees. Despite its frequent use, little research has been conducted to validate results of the CITYgreen energy conservation module. The first objective of this study is to perform a familiar application of CITYgreen software to predict the potential energy savings contribution of existing tree canopies in residential neighborhoods during peak cooling summer months. Unlike previous studies utilizing CITYgreen, this study also seeks to assess the software's performance by comparing model results (i.e., predicted energy savings) with actual savings (i.e., savings derived directly from energy consumption data provided by the electric utility provider). Homeowners in an older neighborhood with established trees were found to use less energy for air-conditioning than homeowners in a recently developed site. Results from the assessment of model performance indicated that CITYgreen more accurately estimated the energy savings in the highly vegetated, older neighborhood.

  6. Performing impact evaluations in industrial retrofit: The Energy Savings Plan Program

    SciTech Connect

    Riewer, S.; Spanner, G.E.

    1991-08-01

    The Energy Savings Plan (ESP) is Bonneville Power Administration`s retrofit program for the industrial sector. The program pays incentives for energy conservation measures involving electrical energy efficiency improvements in manufacturing, processing, and refining industries. This paper will describe the ESP program, recount the techniques selected to evaluate the retrofits, and report the findings from five ESP project impact evaluations completed to date. The impact evaluations provide a framework for assessing the energy saving achieved by the provides implemented under the ESP. In addition to energy savings, the evaluations assess process changes, net utility impacts, levelized costs, and ``free ridership.`` The five ESP projects evaluated include: a waste heat recovery system for a food processing blancher, an energy management control system used to upgrade refrigeration, a variable speed drive for a fan motor in a lumber mill, a sludge screw press for waste water treatment, and replacement of rod anodes with blades anodes in mercury cells in an electrochemical plant.

  7. Performing impact evaluations in industrial retrofit: The Energy Savings Plan Program

    SciTech Connect

    Riewer, S. ); Spanner, G.E. )

    1991-08-01

    The Energy Savings Plan (ESP) is Bonneville Power Administration's retrofit program for the industrial sector. The program pays incentives for energy conservation measures involving electrical energy efficiency improvements in manufacturing, processing, and refining industries. This paper will describe the ESP program, recount the techniques selected to evaluate the retrofits, and report the findings from five ESP project impact evaluations completed to date. The impact evaluations provide a framework for assessing the energy saving achieved by the provides implemented under the ESP. In addition to energy savings, the evaluations assess process changes, net utility impacts, levelized costs, and free ridership.'' The five ESP projects evaluated include: a waste heat recovery system for a food processing blancher, an energy management control system used to upgrade refrigeration, a variable speed drive for a fan motor in a lumber mill, a sludge screw press for waste water treatment, and replacement of rod anodes with blades anodes in mercury cells in an electrochemical plant.

  8. Energy Savings Forecast of Solid-State Lighting in General Illumination Applications

    SciTech Connect

    none,

    2014-08-29

    With declining production costs and increasing technical capabilities, LED adoption has recently gained momentum in general illumination applications. This is a positive development for our energy infrastructure, as LEDs use significantly less electricity per lumen produced than many traditional lighting technologies. The U.S. Department of Energy’s Energy Savings Forecast of Solid-State Lighting in General Illumination Applications examines the expected market penetration and resulting energy savings of light-emitting diode, or LED, lamps and luminaires from today through 2030.

  9. Energy Savings Potential and Research, Development, & Demonstration Opportunities for Commercial Building Appliances

    SciTech Connect

    Zogg, Robert; Goetzler, William; Ahlfeldt, Christopher; Hiraiwa, Hirokazu; Sathe, Amul; Sutherland, Timothy

    2009-12-01

    This study characterizes and assesses the appliances used in commercial buildings. The primary objectives of this study were to document the energy consumed by commercial appliances and identify research, development and demonstration (RD&D) opportunities for efficiency improvements, excluding product categories such as HVAC, building lighting, refrigeration equipment, and distributed generation systems. The study included equipment descriptions, characteristics of the equipment’s market, national energy consumption, estimates of technical potential for energy-saving technologies, and recommendations for U.S. Department of Energy programs that can promote energy savings in commercial appliances.

  10. Heme oxygenase-1 as a potential therapeutic target for hepatoprotection.

    PubMed

    Farombi, Ebenezer Olatunde; Surh, Young Joon

    2006-09-30

    Heme oxygenase (HO), the rate limiting enzyme in the breakdown of heme into carbon monoxide (CO), iron and bilirubin, has recently received overwhelming research attention. To date three mammalian HO isozymes have been identified, and the only inducible form is HO-1 while HO-2 and HO-3 are constitutively expressed. Advances in unveiling signal transduction network indicate that a battery of redox-sensitive transcription factors, such as activator protein-1 (AP-1), nuclear factor-kappa B (NF-kappaB) and nuclear factor E2-related factor-2 (Nrf2), and their upstream kinases including mitogen-activated protein kinases play an important regulatory role in HO-1 gene induction. The products of the HO-catalyzed reaction, particularly CO and biliverdin/bilirubin have been shown to exert protective effects in several organs against oxidative and other noxious stimuli. In this context, it is interesting to note that induction of HO-1 expression contributes to protection against liver damage induced by several chemical compounds such as acetaminophen, carbon tetrachloride and heavy metals, suggesting HO-1 induction as an important cellular endeavor for hepatoprotection. The focus of this review is on the significance of targeted induction of HO-1 as a potential therapeutic strategy to protect against chemically-induced liver injury as well as hepatocarcinogenesis. PMID:17002867

  11. 78 FR 24736 - Energy Savings Performance Contracts: Extension of Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-26

    ... improvements to ESPCs, with emphasis on improvements to the FEMP IDIQ contracts. (78 FR 20097) Comments and...), Request for Proposals (RFP), etc.) to the time of award. Process improvements and simplifications, while... improvements to Energy Savings Performance Contracts (ESPCs), to be submitted by May 3, 2013. In an interest...

  12. Development of Design Guidance for K-12 Schools from 30% to 50% Energy Savings: Preprint

    SciTech Connect

    Pless, S.; Torcellini, P.; Long, N.

    2008-07-01

    This paper describes the development of energy efficiency recommendations for achieving 30% whole-building energy savings in K-12 schools over levels achieved by following the ANSI/ASHRAE/IESNA Standard 90.1. These design recommendations look at building envelope, fenestration, lighting systems (including electrical lights and daylighting), HVAC systems, building automation and controls, outside air treatment, and service water heating.

  13. Green Energy in New Construction: Maximize Energy Savings and Minimize Cost

    ERIC Educational Resources Information Center

    Ventresca, Joseph

    2010-01-01

    People often use the term "green energy" to refer to alternative energy technologies. But green energy doesn't guarantee maximum energy savings at a minimum cost--a common misconception. For school business officials, green energy means getting the lowest energy bills for the lowest construction cost, which translates into maximizing green energy…

  14. Low Energy Technology. A Unit of Instruction in Agricultural Economics. Planning for Energy Savings.

    ERIC Educational Resources Information Center

    Utley, Michael; Scanlon, Dennis C.

    This unit of instruction on farm management for energy savings was designed for use by agribusiness and natural resources teachers in Florida high schools and by agricultural extension agents as they work with adults and students. It is one of a series of 11 instructional units (see note) written to help teachers and agents to educate their…

  15. Durability of high-albedo roof coatings and implications for cooling energy savings. Final report

    SciTech Connect

    Bretz, S.E.; Akbari, H.

    1994-06-01

    Twenty-six spot albedo measurements of roofs were made using a calibrated pyranometer. The roofs were surfaced with either an acrylic elastomeric coating, a polymer coating with an acrylic base, or a cementitious coating. Some of the roofs` albedos were measured before and after washing to determine whether the albedo decrease was permanent. Data indicated that most of the albedo degradation occurred within the first year, and even within the first two months. On one roof, 70% of one year`s albedo degradation occurred in the first two months. After the first year, the degradation slowed, with data indicating small losses in albedo after the second year. Measurements of seasonal cooling energy savings by Akbari et al. (1993) included the effects of over two months of albedo degradation. We estimated {approximately}20% loss in cooling-energy savings after the first year because of dirt accumulation. For most of the roofs we cleaned, the albedo was restored to within 90% of its initial value. Although washing is effective at restoring albedo, the increase in energy savings is temporary and labor costs are significant in comparison to savings. By our calculations, it is not cost-effective to hire someone to clean a high-albedo roof only to achieve energy savings. Thus, it would be useful to develop and identify dirt-resistant high-albedo coatings.

  16. Up Close and Personal: The Value of Feedback in Implementing an Individual Energy-Saving Adaptation

    ERIC Educational Resources Information Center

    Pollard, Carol Elaine

    2016-01-01

    Purpose: The purpose of this research is to explore the drivers of computer-related sustainability behavior at a medium-sized US university and the extent to which an inexpensive energy-saving device installed on 146 administrator, faculty and general staff workstations achieved significant savings in kWh, CO[subscript 2] kg and dollars.…

  17. Measure Guideline. Replacing Single-Speed Pool Pumps with Variable Speed Pumps for Energy Savings

    SciTech Connect

    Hunt, A.; Easley, S.

    2012-05-01

    This measure guideline evaluates potential energy savings by replacing traditional single-speed pool pumps with variable speed pool pumps, and provides a basic cost comparison between continued uses of traditional pumps verses new pumps. A simple step-by-step process for inspecting the pool area and installing a new pool pump follows.

  18. Technical Support Document: Strategies for 50% Energy Savings in Large Office Buildings

    SciTech Connect

    Leach, M.; Lobato, C.; Hirsch, A.; Pless, S.; Torcellini, P.

    2010-09-01

    This Technical Support Document (TSD) documents technical analysis that informs design guidance for designing and constructing large office buildings that achieve 50% net site energy savings over baseline buildings defined by minimal compliance with respect to ANSI/ASHRAE/IESNA Standard 90.1-2004. This report also represents a step toward developing a methodology for using energy modeling in the design process to achieve aggressive energy savings targets. This report documents the modeling and analysis methods used to identify design recommendations for six climate zones that capture the range of U.S. climate variability; demonstrates how energy savings change between ASHRAE Standard 90.1-2007 and Standard 90.1-2004 to determine baseline energy use; uses a four-story 'low-rise' prototype to analyze the effect of building aspect ratio on energy use intensity; explores comparisons between baseline and low-energy building energy use for alternate energy metrics (net source energy, energy emissions, and energy cost); and examines the extent to which glass curtain construction limits achieve energy savings by using a 12-story 'high-rise' prototype.

  19. A Save-Energy, Save-Money Program That Pays Off

    ERIC Educational Resources Information Center

    Embersits, John F.

    1976-01-01

    Suggested guidelines for energy saving on campus include a 3-phase plan: (1) Quick Fix--effective management of what you already have; (2) Refitting--modification of existing systems and installation of simple controls; (3) Systems Convert--installation of computerized controls, waste-heat recovery, solid-waste recovery utilization and other…

  20. Measure Guideline: Replacing Single-Speed Pool Pumps with Variable Speed Pumps for Energy Savings

    SciTech Connect

    Hunt, A.; Easley, S.

    2012-05-01

    The report evaluates potential energy savings by replacing traditional single-speed pool pumps with variable speed pool pumps, and provide a basic cost comparison between continued uses of traditional pumps verses new pumps. A simple step-by-step process for inspecting the pool area and installing a new pool pump follows.

  1. Energy Savings and Breakeven Costs for Residential Heat Pump Water Heaters in the United States

    SciTech Connect

    Maguire, Jeff; Burch, Jay; Merrigan, Tim; Ong, Sean

    2013-07-01

    Heat pump water heaters (HPWHs) have recently re-emerged in the U.S. residential water heating market and have the potential to provide homeowners with significant energy savings. However, there are questions as to the actual performance and energy savings potential of these units, in particular in regards to the heat pump's performance in unconditioned space and the impact of the heat pump on space heating and cooling loads when it is located in conditioned space. To help answer these questions, NREL performed simulations of a HPWH in both conditioned and unconditioned space at over 900 locations across the continental United States and Hawaii. Simulations included a Building America benchmark home so that any interaction between the HPWH and the home's HVAC equipment could be captured. Comparisons were performed to typical gas and electric water heaters to determine the energy savings potential and cost effectiveness of a HPWH relative to these technologies. HPWHs were found to have a significant source energy savings potential when replacing typical electric water heaters, but only saved source energy relative to gas water heater in the most favorable installation locations in the southern United States. When replacing an electric water heater, the HPWH is likely to break even in California, the southern United States, and parts of the northeast in most situations. However, the HPWH will only break even when replacing a gas water heater in a few southern states.

  2. Energy Savings and Breakeven Cost for Residential Heat Pump Water Heaters in the United States

    SciTech Connect

    Maguire, J.; Burch, J.; Merrigan, T.; Ong, S.

    2013-07-01

    Heat pump water heaters (HPWHs) have recently reemerged in the U.S. residential water heating market and have the potential to provide homeowners with significant energy savings. However, there are questions as to the actual performance and energy savings potential of these units, in particular in regards to the heat pump's performance in unconditioned space and the impact of the heat pump on space heating and cooling loads when it is located in conditioned space. To help answer these questions, simulations were performed of a HPWH in both conditioned and unconditioned space at over 900 locations across the continental United States and Hawaii. Simulations included a Building America benchmark home so that any interaction between the HPWH and the home's HVAC equipment could be captured. Comparisons were performed to typical gas and electric water heaters to determine the energy savings potential and cost effectiveness of a HPWH relative to these technologies. HPWHs were found to have a significant source energy savings potential when replacing typical electric water heaters, but only saved source energy relative to gas water heater in the most favorable installation locations in the southern US. When replacing an electric water heater, the HPWH is likely to break even in California, the southern US, and parts of the northeast in most situations. However, the HPWH will only break even when replacing a gas water heater in a few southern states.

  3. 3M's Model Rewards and Recognition Program Engages Employees and Drives Energy Savings Efforts

    SciTech Connect

    2010-06-11

    3M has implemented more than 1,900 employee-inspired projects that have realized a 22% improvement in energy efficiency and yielded $100 million in energy savings. This case study provides information about 3M's approach to energy efficiency.

  4. 77 FR 23373 - Small Business Investment Companies-Energy Saving Qualified Investments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-19

    ... implement the SBIC-related provisions of the Energy Act (76 FR 2029). SBA received eleven sets of comments... any type of preprocessing of biomass should be evaluated on a case-by-case basis under paragraph (4..., which has the same structure as the Energy Saving Debenture, and on venture capital industry data...

  5. Measured Field Performance and Energy Savings of Occupancy Sensors: Three Case Studies.

    ERIC Educational Resources Information Center

    Floyd, David B.; Parker, Danny S.; Sherwin, John R.

    A study determined the performance levels, energy savings, and occupant acceptance of occupancy sensors that were installed in a Florida small office building and two elementary schools. Performance data was collected in 15-minute intervals. Aggregate time-of-day lighting load profiles were compared before and after the installation and throughout…

  6. Group Home Energy Efficiency Retrofit for 30% Energy Savings: Washington, D.C. (Fact Sheet)

    SciTech Connect

    Not Available

    2013-11-01

    Energy efficiency retrofits (EERs) face many challenges on the path to scalability. Limited budgets, cost effectiveness, risk factors, and accessibility impact the type and the extent of measures that can be implemented feasibly to achieve energy savings goals. Group home retrofits can face additional challenges than those in single family homes - such as reduced access (occupant-in-place restrictions) and lack of incentives for occupant behavioral change. This project studies the specification, implementation, and energy savings from an EER in a group home, with an energy savings goal of 30%. This short term test report chronicles the retrofit measures specified, their projected cost-effectiveness using building energy simulations, and the short term test results that were used to characterize pre-retrofit and post-retrofit conditions. Additionally, the final report for the project will include analysis of pre- and post-retrofit performance data on whole building energy use, and an assessment of the energy impact of occupant interface with the building (i.e., window operation). Ultimately, the study's results will be used to identify cost effective EER measures that can be implemented in group homes, given constraints that are characteristic of these buildings. Results will also point towards opportunities for future energy savings.

  7. Application and energy saving potential of superheated steam drying in the food industry

    SciTech Connect

    Fitzpatrick, J.; Robinson, A.

    1996-12-31

    The possibilities of using superheated steam in heat and mass transfer processes such as drying have lately been investigated and tested by several industries. The mode of operation, energy saving potential, advantages of and problems with this media in contact with foodstuffs and food waste sludge are discussed in this article.

  8. The energy saving potential of precooling incoming outdoor air by indirect evaporative cooling

    SciTech Connect

    Chen, P.; Qin, H.; Huang, Y.J.; Wu, H.; Blumstein, C.

    1992-09-01

    This paper investigates the energy saving potentials of using indirect evaporative coolers to precool incoming outdoor air as the first stage of a standard cooling system. For dry and moderately humid locations, either exhaust room air or outdoor air can be used as the secondary air to the indirect evaporative precooler with similar energy savings. Under these conditions, the use of outdoor air is recommended due to the simplicity in installing the duct system. For humid locations, the use of exhaust room air is recommended because the precooling capacity and energy savings will be greatly increased. For locations with short cooling seasons, the use of indirect evaporative coolers for precooling may not be worthwhile. The paper also gives some simplified indices for easily predicting the precooling capacity, energy savings and water consumption of an indirect evaporative precooler. These indices can be used for cooling systems with continuous operation, but further work is needed to determine whether the same indices are also suitable for cooling systems with intermittent operations.

  9. Determining Energy Saving Behavior and Energy Awareness of Secondary School Students According to Socio-Demographic Characteristics

    ERIC Educational Resources Information Center

    Aktamis, Hilal

    2011-01-01

    The aim of this study was to determine energy saving behavior and energy awareness of secondary school students and the effects of socio-demographic characteristics (gender, residential area and grade level) on energy saving and energy awareness. The research is a survey model with an approach that aims to describe the current status. A total of…

  10. Energy saving tire with silica-rich tread

    SciTech Connect

    Ahmad, S.; Schaefer, R. J.

    1985-05-28

    A pneumatic radial tire is provided with a tread having from 1 part by weight of hydrated amorphous fine-particle silica per 3 parts of carbon black tread reinforcing filler, to about 3 parts by weight of the silica to 1 part of the carbon black. The amount of silica present is preferably in the range from about 18 parts to about 50 parts by weight per 100 parts of natural or synthetic rubber. When such a tread is compounded with a mercaptosilane in which the mercapto group is reversibly blocked, the tread provides reduced rolling resistance without loss of traction. Such reduction in rolling resistance without loss of traction is not observed when the silica is not coupled with the mercaptosilane coupling agent.

  11. Hydrodynamics and energy-saving swimming techniques of Pacific bluefin tuna.

    PubMed

    Takagi, Tsutomu; Tamura, Yumiko; Weihs, Daniel

    2013-11-01

    Weihs theoretically revealed that during the movement of fish with negative buoyancy, more kinetic energy is saved in the glide and upward (GAU) swimming mode than in the continuous horizontal swimming mode. Because kinetic energy saving depends on dynamic parameters such as the drag and lift of the body, the effects of variations in these parameters on energy saving for different species remain unknown. Here, the kinetic energy saving of Pacific bluefin tuna (PBT), Thunnus orientalis, exhibiting the GAU swimming mode was investigated. The dynamic properties of PBT were estimated by carrying out CFD analysis. The CFD model was produced by using a three-dimensional laser surface profiler, and the model was controlled such that it exhibited swimming motion similar to that of a live PBT swimming in a flume tank. The drag generated by tail beating, which significantly affects the kinetic energy during motion, was twice that generated in the glide mode. The faster the upward swimming speed, the lesser is the kinetic energy saving; therefore, when the upward swimming speed is more than twice the glide speed, there is no gain in the GAU mode. However, when SMR (Standard Metabolic Rate) is considered, if the energy based on SMR is assumed to be 30% of the total energy spent during motion, the most efficient upward swimming speed is 1.4 times the glide speed. The GAU swimming mode of PBT leads to energy saving during motion, and the upward swimming speed and the lift force produced by the pectoral fins for the most efficient drive are unique for different species of different sizes.

  12. Energy saving effects of wireless sensor networks: a case study of convenience stores in Taiwan.

    PubMed

    Chen, Chih-Sheng; Lee, Da-Sheng

    2011-01-01

    Wireless sensor network (WSN) technology has been successfully applied to energy saving applications in many places, and plays a significant role in achieving power conservation. However, previous studies do not discuss WSN costs and cost-recovery. The application of WSNs is currently limited to research and laboratory experiments, and not mass industrial production, largely because business owners are unfamiliar with the possible favorable return and cost-recovery on WSN investments. Therefore, this paper focuses on the cost-recovery of WSNs and how to reduce air conditioning energy consumption in convenience stores. The WSN used in this study provides feedback to the gateway and adopts the predicted mean vote (PMV) and computational fluid dynamics (CFD) methods to allow customers to shop in a comfortable yet energy-saving environment. Four convenience stores in Taipei have used the proposed WSN since 2008. In 2008, the experiment was initially designed to optimize air-conditioning for energy saving, but additions to the set-up continued beyond 2008, adding the thermal comfort and crowds peak, off-peak features in 2009 to achieve human-friendly energy savings. Comparison with 2007 data, under the same comfort conditions, shows that the power savings increased by 40% (2008) and 53% (2009), respectively. The cost of the WSN equipment was 500 US dollars. Experimental results, including three years of analysis and calculations, show that the marginal energy conservation benefit of the four convenience stores achieved energy savings of up to 53%, recovering all costs in approximately 5 months. The convenience store group participating in this study was satisfied with the efficiency of energy conservation because of the short cost-recovery period.

  13. Energy Saving Effects of Wireless Sensor Networks: A Case Study of Convenience Stores in Taiwan

    PubMed Central

    Chen, Chih-Sheng; Lee, Da-Sheng

    2011-01-01

    Wireless sensor network (WSN) technology has been successfully applied to energy saving applications in many places, and plays a significant role in achieving power conservation. However, previous studies do not discuss WSN costs and cost-recovery. The application of WSNs is currently limited to research and laboratory experiments, and not mass industrial production, largely because business owners are unfamiliar with the possible favorable return and cost-recovery on WSN investments. Therefore, this paper focuses on the cost-recovery of WSNs and how to reduce air conditioning energy consumption in convenience stores. The WSN used in this study provides feedback to the gateway and adopts the predicted mean vote (PMV) and computational fluid dynamics (CFD) methods to allow customers to shop in a comfortable yet energy-saving environment. Four convenience stores in Taipei have used the proposed WSN since 2008. In 2008, the experiment was initially designed to optimize air-conditioning for energy saving, but additions to the set-up continued beyond 2008, adding the thermal comfort and crowds peak, off-peak features in 2009 to achieve human-friendly energy savings. Comparison with 2007 data, under the same comfort conditions, shows that the power savings increased by 40% (2008) and 53% (2009), respectively. The cost of the WSN equipment was 500 US dollars. Experimental results, including three years of analysis and calculations, show that the marginal energy conservation benefit of the four convenience stores achieved energy savings of up to 53%, recovering all costs in approximately 5 months. The convenience store group participating in this study was satisfied with the efficiency of energy conservation because of the short cost-recovery period. PMID:22319396

  14. Simultaneous Energy Savings and IEQ Improvements in Relocatable Classrooms

    SciTech Connect

    Apte, Michael G.; Dibartolomeo, Dennis; Hotchi, Toshi; Hodgson, Alfred T.; Lee, Seung-Min; Liff, Shawna M.; Rainer, Leo I.; Shendell, Derek G.; Sullivan, Doug P.; Fisk, William J.

    2003-05-22

    Relocatable classrooms (RCs) are commonly used by school districts with changing demographics and enrollment sizes. We designed and constructed four energy-efficient RCs for this study to demonstrate technologies with the potential to simultaneously improve energy efficiency and indoor environmental quality (IEQ). Two were installed at each of two school districts, and energy use and IEQ parameters were monitored during occupancy. Two RCs (one per school) were finished with materials selected for reduced emissions of toxic and odorous volatile organic compounds (VOCs). Each had two HVAC systems, operated on alternate weeks, consisting of a standard heat-pump system and an indirect-direct evaporative cooling (IDEC) system with gas-fired hydronic heating. The IDEC system provides continuous outside air ventilation at {sup 3}15 CFM (7.5 L s-1) person-1, efficient particle filtration while using significantly less energy for cooling. School year long measurements included: carbon dioxide (CO2), particles, VOCs, temperature, humidity, thermal comfort, noise, meteorology, and energy use. IEQ monitoring results indicate that important ventilation-relevant indoor CO2 and health-relevant VOC concentration reductions were achieved while average cooling and heating energy costs were simultaneously reduced by 50 percent and 30 percent, respectively.

  15. Actual and Estimated Energy Savings Comparison for Deep Energy Retrofits in the Pacific Northwest

    SciTech Connect

    Blanchard, Jeremy; Widder, Sarah H.; Giever, Elisabeth L.; Baechler, Michael C.

    2012-10-01

    Seven homes from the Pacific Northwest were selected to evaluate the differences between estimated and actual energy savings achieved from deep energy retrofits. The energy savings resulting from these retrofits were estimated, using energy modeling software, to save at least 30% on a whole-house basis. The modeled pre-retrofit energy use was trued against monthly utility bills. After the retrofits were completed, each of the homes was extensively monitored, with the exception of one home which was monitored pre-retrofit. This work is being conducted by Pacific Northwest National Laboratory (PNNL) for the U.S. Department of Energy Building Technologies Program as part of the Building America Program. This work found many discrepancies between actual and estimated energy savings and identified the potential causes for the discrepancies. The differences between actual energy use and modeled energy use also suggest improvements to improve model accuracy. The difference between monthly whole-house actual and estimated energy savings ranged from 75% more energy saved than predicted by the model to 16% less energy saved for all the monitored homes. Similarly, the annual energy savings difference was between 36% and -14%, which was estimated based on existing monitored savings because an entire year of data is not available. Thus, on average, for all six monitored homes the actual energy use is consistently less than estimates, indicating home owners are saving more energy than estimated. The average estimated savings for the eight month monitoring period is 43%, compared to an estimated savings average of 31%. Though this average difference is only 12%, the range of inaccuracies found for specific end-uses is far greater and are the values used to directly estimate energy savings from specific retrofits. Specifically, the monthly post-retrofit energy use differences for specific end-uses (i.e., heating, cooling, hot water, appliances, etc.) ranged from 131% under

  16. The impact of translucent fabric shades and control strategies on energy savings and visual quality

    NASA Astrophysics Data System (ADS)

    Wankanapon, Pimonmart

    Translucent fabric shades provide opportunities for building occupants to control sunlight penetration for heat reduction, thermal comfort, and visual quality. Regulating shades affects building energy and can potentially reduce the size of mechanical cooling systems. Shades are not normally included in energy model studies during the design process, even though shades potential impact energy use. This is because the occupants normally leave shades closed a large fraction of the time, but models are generally performed with no shades. Automatic shade control is now available, so it is necessary to understand the impact of shades on visual quality and their energy saving potential in order to optimize their overall performance. There are very limited studies that have address shades and their integrated performance on energy consumption and visual quality. Most of these do not reflected modern shade types and their application. The goals of this study are: First, to determine the impact of shades on total, heating, cooling and lighting energy savings with different design and operation parameters. Second, to study and develop different automatic shade control strategies to promote and optimize energy savings and visual quality. A simulation-based approach using EnergyPlus in a parametric study provide better understanding energy savings under different shade conditions. The parametric runs addressed various building parameters such as geometry, orientation, site climate, glazing/shade properties, and shade control strategies with integrated lighting control. The impact of shades was determined for total building and space heating, cooling and lighting energy savings. The effect of shades on visual quality was studied using EnergyPlus, AGI32 and DAYSIM for several indices such as daylight glare index (DGI), work plane illuminance, luminance ratios and view. Different shade control strategies and integrated lighting control were considered with two translucent fabric

  17. Immunosuppressive and hepatoprotective potential of Sarcococca saligna and its biomarker components.

    PubMed

    Ali, Hamid; Musharraf, Syed Ghulam; Iqbal, Naveed; Adhikari, Achyut; Abdalla, Omer Mohamed; Ahmed Mesaik, M; Kabir, Nurul

    2015-09-01

    Sarcococca saligna methanolic extract, fractions and isolated pure compounds saracocine (1), saracodine (2), pachyximine-A (3) and terminaline (4) were found to possess potent immunosuppressive activities. The fractions and compounds were tested in-vitro for their effects on human T-cell proliferation, and cytokine (IL-2) production. All the fractions, sub-fractions and purified compounds showed significant suppressive effect on IL-2 production in a dose-dependent manner. They also exhibited a suppressive effect on the phytohemagglutinin-stimulated T-cell proliferation. None of the extracts and purified compounds showed any cytotoxicity effects on the 3T3 mice fibroblast cell line. The crude extract, DCM fraction (pH9), DCM fractions (pH7) and one of the steroidal alkaloids (terminaline) were checked in-vivo for their hepato-protective potential against CCl4-induced liver injury. In in-vivo experiments, the basic and neutral DCM fractions and terminaline (4) significantly reduced inflammation in the liver. DCM fraction (pH9), DCM fractions (pH7) and compound 4 reduced the serum enzyme levels (ALT, AST, and ALP) down to control levels despite CCl4 treatment. They also reduced the CCl4-induced damaged area to almost zero as assessed by histopathology. The pale necrotic areas and mixed inflammatory infiltrate which are seen after CCl4 treatment were absent in the cases of basic, neutral fractions and terminaline treatment. These hepato-protective effects were better than the positive control silymarin. Our results suggest the therapeutic effect of S. saligna extract, fractions and bioactive steroidal alkaloids against CCl4-induced liver injury in vivo and their immunosuppressive function in vitro.

  18. Antioxidant and hepatoprotective activities of polysaccharides from Anoectochilus roxburghii.

    PubMed

    Zeng, Biyu; Su, Minghua; Chen, Qingxi; Chang, Qiang; Wang, Wei; Li, Huihua

    2016-11-20

    The physicochemical properties (molecular weights and monosaccharide compositions), antioxidant and hepatoprotective activities of polysaccharides (ARPPs: ARPP30, ARPP60 and ARPP80) isolated from Anoectochilus roxburghii were investigated. ARPP80 exhibited relatively strong antioxidant activities in a concentration-dependent manner. In mice subjected to carbon tetrachloride-induced hepatotoxicity, ARPP80 pretreatment significantly (p<0.01) reduced the levels of aspartate and alanine amino transferases and malonyldialdehyde, prominently (p<0.01) restored the levels of superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione in serum or liver homogenate. These hepatoprotective effects were comparable to those of the standard drug silymarin at the same dose (200mg/kg). The study clearly demonstrated that ARPPs, especially ARPP80, might be suitable as functional foods or hepatoprotective drugs. PMID:27561510

  19. A simple tool for estimating city-wide annual electrical energy savings from cooler surfaces

    SciTech Connect

    Pomerantz, Melvin; Rosado, Pablo J.; Levinson, Ronnen M.

    2015-06-27

    We present a simple method to estimate the maximum possible electrical energy saving that might be achieved by increasing the albedo of surfaces in a large city. We restrict this to the “indirect effect”, the cooling of outside air that lessens the demand for air conditioning (AC). Given the power demand of the electric utilities and data about the city, we can use a single linear equation to estimate the maximum savings. For example, the result for an albedo change of 0.2 of pavements in a typical warm city in California, such as Sacramento, is that the saving is less than about 2 kWh per m2 per year. This may help decision makers choose which heat island mitigation techniques are economical from an energy-saving perspective.

  20. Technical Support Document: Development of the Advanced Energy Design Guide for Large Hospitals - 50% Energy Savings

    SciTech Connect

    Bonnema, E.; Leach, M.; Pless, S.

    2013-06-01

    This Technical Support Document describes the process and methodology for the development of the Advanced Energy Design Guide for Large Hospitals: Achieving 50% Energy Savings Toward a Net Zero Energy Building (AEDG-LH) ASHRAE et al. (2011b). The AEDG-LH is intended to provide recommendations for achieving 50% whole-building energy savings in large hospitals over levels achieved by following Standard 90.1-2004. The AEDG-LH was created for a 'standard' mid- to large-size hospital, typically at least 100,000 ft2, but the strategies apply to all sizes and classifications of new construction hospital buildings. Its primary focus is new construction, but recommendations may be applicable to facilities undergoing total renovation, and in part to many other hospital renovation, addition, remodeling, and modernization projects (including changes to one or more systems in existing buildings).

  1. Energy saving characteristics of a new type of road-heating system

    NASA Astrophysics Data System (ADS)

    Sugawara, N.; Hokari, K.; Watanabe, T.; Sugawara, H.

    In order to drive safely and smoothly in winter, there is a need to clear the snow and ice accumulated on steep slopes and at congested intersections. For this purpose a large number of road-heating systems are installed at such places. However the operating costs of electrical road-heating systems to melt snow on pavement are high compared to mechanical and chemical ways. Therefore the development of efficient electrical road-heating systems is needed. In this paper, we describe the energy saving characteristics of a new type of road-heating system electrical output of which is based on snowfall probabilities. This new type of road-heating system was tested on an actual road from December 1992 to March 1994 in winter. The energy consumption of this system was compared with those of present-day energy saving road-heating systems.

  2. Replacement of chemical intensive water treatment processes with energy saving membrane. Final report

    SciTech Connect

    Mickley, M.C.; Goering, S.W.

    1983-11-01

    The project investigated the use of charged ultrafiltration membranes to treat hard water. More specifically, the work was undertaken to (1) make charged ultrafiltration membranes to demonstrate the technical feasibility of the chemical grafting approach; (2) evaluate the market potential for charged ultrafiltration membranes; and (3) evaluate the cost and energy savings for using charged ultrafiltration as compared to lime-based clarification and other treatment methods. The results suggest that chemical grafting is a relatively simple, reproducible and low-cost way to modify existing substrate materials to give them enhanced transport performance. Process studies lead to the identification of good market potential for membrane processes using charged ultrafiltration membranes. Capital and operating costs relative to lime-based clarification are favorable for low- and medium-sized treatment plants. Finally, substantial energy savings are apparent as compared to lime-based precipitation systems which incur substantial energy consumption in the lime production and transportation steps.

  3. Development of the Advanced Energy Design Guide for K-12 Schools -- 50% Energy Savings

    SciTech Connect

    Bonnema, E.; Leach, M.; Pless, S.; Torcellini, P.

    2013-02-01

    This Technical Support Document (TSD) describes the process and methodology for the development of the Advanced Energy Design Guide for K-12 School Buildings: Achieving 50% Energy Savings Toward a Net Zero Energy Building (AEDG-K12) (ASHRAE et al. 2011a). The AEDG-K12 provides recommendations for achieving 50% whole-building energy savings in K-12 schools over levels achieved by following ANSI/ASHRAE/IESNA Standard 90.1-2004, Energy Standard for Buildings Except Low-Rise Residential Buildings (Standard 90.1-2004) (ASHRAE 2004b). The AEDG-K12 was developed in collaboration with the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE), the American Institute of Architects (AIA), the Illuminating Engineering Society of North America (IES), the U.S. Green Building Council (USGBC), and the U.S. Department of Energy (DOE).

  4. Building America Residential System Research Results: Achieving 30% Whole House Energy Savings Level in Cold Climates

    SciTech Connect

    Building Industry Research Alliance; Building Science Consortium; Consortium for Advanced Residential Buildings; Florida Solar Energy Center; IBACOS; National Renewable Energy Laboratory

    2006-08-01

    The Building America program conducts the system research required to reduce risks associated with the design and construction of homes that use an average of 30% to 90% less total energy for all residential energy uses than the Building America Research Benchmark, including research on homes that will use zero net energy on annual basis. To measure the program's progress, annual research milestones have been established for five major climate regions in the United States. The system research activities required to reach each milestone take from 3 to 5 years to complete and include research in individual test houses, studies in pre-production prototypes, and research studies with lead builders that provide early examples that the specified energy savings level can be successfully achieved on a production basis. This report summarizes research results for the 30% energy savings level and demonstrates that lead builders can successfully provide 30% homes in Cold Climates on a cost-neutral basis.

  5. Relationship Between Liquor Yield, Plant Capacity Increases, and Energy Savings in Alumina Refining

    NASA Astrophysics Data System (ADS)

    Ter Weer, Peter-Hans

    2014-09-01

    The mechanisms of alumina trihydrate precipitation and controlling parameters, and the methods and technologies affecting liquor yield/productivity in alumina refining, have been described in several publications [e.g., Refs. Alamdari et al. ( Light Metals 1998, pp. 133-137, 1998), Moretto and Power ( Proc. 1990 Alumina Quality Workshop, Perth, Australia, pp. 154-165, 1990)]. However, the relationship between increasing liquor yield, on the one hand, and plant production capacity increases and related energy savings, on the other, has been under-emphasized. This article addresses this issue and provides estimates of plant production capacity increases and steam and power energy savings as a function of precipitation yield increases resulting from the implementation of plant adaptations. Conclusions are that increasing precipitation yield in an alumina refinery results overall in a significant improvement of project economics and interestingly improves a refinery's direct and indirect environmental performance, thus, addressing two of the three "pillars" of sustainable development (economic, environmental, and social).

  6. Analysis of Energy Saving Impacts of ASHRAE 90.1-2004 for New York

    SciTech Connect

    Gowri, Krishnan; Halverson, Mark A.; Richman, Eric E.

    2007-08-03

    The New York State Energy Research and Development Authority (NYSERDA) and New York State Department of State (DOS) requested the help of DOE’s Building Energy Codes Program (BECP) in estimating the annual building energy savings and cost impacts of adopting ANSI/ASHRAE/IESNA Standard 90.1-2004 (ASHRAE 2004) requirements. This report summarizes the analysis methodology and results of energy simulation in response to that request.

  7. Development of Design Guidance for K-12 Schools: From 30% to 50% Energy Savings

    SciTech Connect

    Pless, S.; Torcellini, P.; Long, N.

    2008-01-01

    This paper describes the development of energy efficiency recommendations for achieving 30% whole-building energy savings in K-12 Schools over levels achieved by following the ANSI/ASHRAE/IESNA Standard 90.1, Energy Standard for Buildings Except Low-Rise Residential Buildings (1999 and 2004 versions). Exhaustive simulations were run to create packages of energy design solutions available over a wide range of K-12 schools and climates. These design recommendations look at building envelope, fenestration, lighting systems (including electrical lights and daylighting), HVAC systems, building automation and controls, outside air treatment, and service water heating. We document and discuss the energy modeling performed to demonstrate that the recommendations will result in at least 30% energy savings over ASHRAE 90.1-1999 and ASHRAE 90.1-2004. Recommendations are evaluated based on the availability of daylighting for the school and by the type of HVAC system. Compared to the ASHRAE 90.1-1999 baseline, the recommendations result in more than 30% savings in all climate zones for both daylit and nondaylit elementary, middle, and high schools with a range of HVAC system types. These recommendations have been included in the Advanced Energy Design Guide for K-12 School Buildings. Compared to the more stringent ASHRAE 90.1-2004 baseline, the recommendations result in more than 30% savings in all climate zones, for only the daylit elementary, middle, and high schools, with a range of HVAC system types. To inform the future development of recommendations for higher level of energy savings, we analyzed a subset of recommendations to understand which energy efficiency technologies would be needed to achieve 50% energy savings.

  8. Technical Support Document: 50% Energy Savings Design Technology Packages for Medium Office Buildings

    SciTech Connect

    Thornton, Brian A.; Wang, Weimin; Lane, Michael D.; Rosenberg, Michael I.; Liu, Bing

    2009-09-01

    This Technical Support Document (TSD) describes the process and methodology for development of the Advanced Energy Design Guide for Medium Offices (AEDG-MO or the Guide), a design guidance document which intends to provide recommendations for achieving 50% energy savings in medium office buildings that just meet the requirements of ANSI/ASHRAE/IESNA Standard 90.1-2004, Energy Standard for Buildings Except Low-Rise Residential Buildings.

  9. Analysis of Installed Measures and Energy Savings for Single-Family Residential Better Buildings Projects

    SciTech Connect

    Heaney, M.; Polly, B.

    2015-04-30

    This report presents an analysis of data for residential single-family projects reported by 37 organizations that were awarded federal financial assistance (cooperative agreements or grants) by the U.S. Department of Energy’s Better Buildings Neighborhood Program.1 The report characterizes the energy-efficiency measures installed for single-family residential projects and analyzes energy savings and savings prediction accuracy for measures installed in a subset of those projects.

  10. Energy Efficiency Opportunities in Highway Lodging Buildings: Development of 50% Energy Savings Design Technology Packages

    SciTech Connect

    Jiang, Wei; Gowri, Krishnan; Thornton, Brian A.; Liu, Bing

    2010-06-30

    This paper presents the process, methodology, and assumptions for development of the 50% Energy Savings Design Technology Packages for Highway Lodging Buildings, a design guidance document that provides specific recommendations for achieving 50% energy savings in roadside motels (highway lodging) above the requirements of ANSI/ASHRAE/IESNA Standard 90.1-2004. This 50% solution represents a further step toward realization of the U.S. Department of Energy’s net-zero energy building goal, and go beyond the 30% savings in the Advanced Energy Design Guide series (upon which this work was built). This work can serve as the technical feasibility study for the development of a 50% saving Advanced Energy Design Guide for highway lodging, and thus should greatly expedite the development process. The purpose of this design package is to provide user-friendly design assistance to designers, developers, and owners of highway lodging properties. It is intended to encourage energy-efficient design by providing prescriptive energy-efficiency recommendations for each climate zone that attains the 50% the energy savings target. This paper describes the steps that were taken to demonstrate the technical feasibility of achieving a 50% reduction in whole-building energy use with practical and commercially available technologies. The energy analysis results are presented, indicating the recommended energy-efficient measures achieved a national-weighted average energy savings of 55%, relative to Standard 90.1-2004. The cost-effectiveness of the recommended technology package is evaluated and the result shows an average simple payback of 11.3 years.

  11. 40% Whole-House Energy Savings in the Hot-Humid Climate

    SciTech Connect

    none,

    2011-09-01

    This guide book is a resource to help builders design and construct highly energy-efficient homes, while addressing building durability, indoor air quality, and occupant health, safety, and comfort. With the measures described in this guide, builders in the hot-humid climate can build homes that achieve whole house energy savings of 40% over the Building America benchmark (the 1993 Model Energy Code) with no added overall costs for consumers.

  12. 40% Whole-House Energy Savings in the Mixed-Humid Climate

    SciTech Connect

    Baechler, Michael C.; Gilbride, T. L.; Hefty, M. G.; Cole, P. C.; Adams, K.; Butner, R. S.; Ortiz, S. J.; Love, Pat M.

    2011-09-01

    This guide book is a resource to help builders design and construct highly energy-efficient homes, while addressing building durability, indoor air quality, and occupant health, safety, and comfort. With the measures described in this guide, builders in the mixed-humid climate can build homes that achieve whole house energy savings of 40% over the Building America benchmark (the 1993 Model Energy Code) with no added overall costs for consumers.

  13. Diffusion Dynamics of Energy Saving Practices in Large Heterogeneous Online Networks

    PubMed Central

    Mohammadi, Neda; Wang, Qi; Taylor, John E.

    2016-01-01

    Online social networks are today’s fastest growing communications channel and a popular source of information for many, so understanding their contribution to building awareness and shaping public perceptions of climate change is of utmost importance. Today’s online social networks are composed of complex combinations of entities and communication channels and it is not clear which communicators are the most influential, what the patterns of communication flow are, or even whether the widely accepted two-step flow of communication model applies in this new arena. This study examines the diffusion of energy saving practices in a large online social network across organizations, opinion leaders, and the public by tracking 108,771 communications on energy saving practices among 1,084 communicators, then analyzing the flow of information and influence over a 28 day period. Our findings suggest that diffusion networks of messages advocating energy saving practices are predominantly led by the activities of dedicated organizations but their attempts do not result in substantial public awareness, as most of these communications are effectively trapped in organizational loops in which messages are simply shared between organizations. Despite their comparably significant influential values, opinion leaders played a weak role in diffusing energy saving practices to a wider audience. Thus, the two-step flow of communication model does not appear to describe the sharing of energy conservation practices in large online heterogeneous networks. These results shed new light on the underlying mechanisms driving the diffusion of important societal issues such as energy efficiency, particularly in the context of large online social media outlets. PMID:27736912

  14. The Conservation Nexus: Valuing Interdependent Water and Energy Savings in Phoenix, Arizona

    NASA Astrophysics Data System (ADS)

    Chester, M.; Bartos, M.

    2013-12-01

    Energy and water resources are intrinsically linked, yet they are managed separately--even in the water-scarce American southwest. This study develops a spatially-explicit model of water-energy interdependencies in Arizona, and assesses the potential for co-beneficial conservation programs. Arizona consumes 2.8% of its water demand for thermoelectric power and 8% of its electricity demand for water infrastructure--roughly twice the national average. The interdependent benefits of investments in 7 conservation strategies are assessed. Deployment of irrigation retrofits and new reclaimed water facilities dominate potential water savings, while residential and commercial HVAC improvements dominate energy savings. Water conservation policies have the potential to reduce statewide electricity demand by 1.0-2.9%, satisfying 5-14% of mandated energy-efficiency goals. Likewise, adoption of energy-efficiency measures and renewable generation portfolios can reduce non-agricultural water demand by 2.0-2.6%. These co-benefits of conservation investments are typically not included in conservation plans or benefit-cost analyses. Residential water conservation measures produce significant water and energy savings, but are generally not cost-effective at current water prices. An evaluation of the true cost of water in Arizona would allow future water and energy savings to be compared objectively, and would help policymakers allocate scarce resources to the highest-value conservation measures. Water Transfers between Water Cycle Components in Arizona in 2008 Cumulative embedded energy in water cycle components in Arizona in 2008

  15. An energy-saving nonlinear position control strategy for electro-hydraulic servo systems.

    PubMed

    Baghestan, Keivan; Rezaei, Seyed Mehdi; Talebi, Heidar Ali; Zareinejad, Mohammad

    2015-11-01

    The electro-hydraulic servo system (EHSS) demonstrates numerous advantages in size and performance compared to other actuation methods. Oftentimes, its utilization in industrial and machinery settings is limited by its inferior efficiency. In this paper, a nonlinear backstepping control algorithm with an energy-saving approach is proposed for position control in the EHSS. To achieve improved efficiency, two control valves including a proportional directional valve (PDV) and a proportional relief valve (PRV) are used to achieve the control objectives. To design the control algorithm, the state space model equations of the system are transformed to their normal form and the control law through the PDV is designed using a backstepping approach for position tracking. Then, another nonlinear set of laws is derived to achieve energy-saving through the PRV input. This control design method, based on the normal form representation, imposes internal dynamics on the closed-loop system. The stability of the internal dynamics is analyzed in special cases of operation. Experimental results verify that both tracking and energy-saving objectives are satisfied for the closed-loop system.

  16. Energy Saving Melting and Revert Reduction Technology: Aging of Graphitic Cast Irons and Machinability

    SciTech Connect

    Richards, Von L.

    2012-09-19

    The objective of this task was to determine whether ductile iron and compacted graphite iron exhibit age strengthening to a statistically significant extent. Further, this effort identified the mechanism by which gray iron age strengthens and the mechanism by which age-strengthening improves the machinability of gray cast iron. These results were then used to determine whether age strengthening improves the machinability of ductile iron and compacted graphite iron alloys in order to develop a predictive model of alloy factor effects on age strengthening. The results of this work will lead to reduced section sizes, and corresponding weight and energy savings. Improved machinability will reduce scrap and enhance casting marketability. Technical Conclusions: Age strengthening was demonstrated to occur in gray iron ductile iron and compacted graphite iron. Machinability was demonstrated to be improved by age strengthening when free ferrite was present in the microstructure, but not in a fully pearlitic microstructure. Age strengthening only occurs when there is residual nitrogen in solid solution in the Ferrite, whether the ferrite is free ferrite or the ferrite lamellae within pearlite. Age strengthening can be accelerated by Mn at about 0.5% in excess of the Mn/S balance Estimated energy savings over ten years is 13.05 trillion BTU, based primarily on yield improvement and size reduction of castings for equivalent service. Also it is estimated that the heavy truck end use of lighter castings for equivalent service requirement will result in a diesel fuel energy savings of 131 trillion BTU over ten years.

  17. An energy-saving nonlinear position control strategy for electro-hydraulic servo systems.

    PubMed

    Baghestan, Keivan; Rezaei, Seyed Mehdi; Talebi, Heidar Ali; Zareinejad, Mohammad

    2015-11-01

    The electro-hydraulic servo system (EHSS) demonstrates numerous advantages in size and performance compared to other actuation methods. Oftentimes, its utilization in industrial and machinery settings is limited by its inferior efficiency. In this paper, a nonlinear backstepping control algorithm with an energy-saving approach is proposed for position control in the EHSS. To achieve improved efficiency, two control valves including a proportional directional valve (PDV) and a proportional relief valve (PRV) are used to achieve the control objectives. To design the control algorithm, the state space model equations of the system are transformed to their normal form and the control law through the PDV is designed using a backstepping approach for position tracking. Then, another nonlinear set of laws is derived to achieve energy-saving through the PRV input. This control design method, based on the normal form representation, imposes internal dynamics on the closed-loop system. The stability of the internal dynamics is analyzed in special cases of operation. Experimental results verify that both tracking and energy-saving objectives are satisfied for the closed-loop system. PMID:26520165

  18. Life-cycle energy savings potential from aluminum-intensive vehicles

    SciTech Connect

    Stodolsky, F.; Vyas, A.; Cuenca, R.; Gaines, L.

    1995-07-01

    The life-cycle energy and fuel-use impacts of US-produced aluminum-intensive passenger cars and passenger trucks are assessed. The energy analysis includes vehicle fuel consumption, material production energy, and recycling energy. A model that stimulates market dynamics was used to project aluminum-intensive vehicle market shares and national energy savings potential for the period between 2005 and 2030. We conclude that there is a net energy savings with the use of aluminum-intensive vehicles. Manufacturing costs must be reduced to achieve significant market penetration of aluminum-intensive vehicles. The petroleum energy saved from improved fuel efficiency offsets the additional energy needed to manufacture aluminum compared to steel. The energy needed to make aluminum can be reduced further if wrought aluminum is recycled back to wrought aluminum. We find that oil use is displaced by additional use of natural gas and nonfossil energy, but use of coal is lower. Many of the results are not necessarily applicable to vehicles built outside of the United States, but others could be used with caution.

  19. Advertising energy saving programs: The potential environmental cost of emphasizing monetary savings.

    PubMed

    Schwartz, Daniel; Bruine de Bruin, Wändi; Fischhoff, Baruch; Lave, Lester

    2015-06-01

    Many consumers have monetary or environmental motivations for saving energy. Indeed, saving energy produces both monetary benefits, by reducing energy bills, and environmental benefits, by reducing carbon footprints. We examined how consumers' willingness and reasons to enroll in energy-savings programs are affected by whether advertisements emphasize monetary benefits, environmental benefits, or both. From a normative perspective, having 2 noteworthy kinds of benefit should not decrease a program's attractiveness. In contrast, psychological research suggests that adding external incentives to an intrinsically motivating task may backfire. To date, however, it remains unclear whether this is the case when both extrinsic and intrinsic motivations are inherent to the task, as with energy savings, and whether removing explicit mention of extrinsic motivation will reduce its importance. We found that emphasizing a program's monetary benefits reduced participants' willingness to enroll. In addition, participants' explanations about enrollment revealed less attention to environmental concerns when programs emphasized monetary savings, even when environmental savings were also emphasized. We found equal attention to monetary motivations in all conditions, revealing an asymmetric attention to monetary and environmental motives. These results also provide practical guidance regarding the positioning of energy-saving programs: emphasize intrinsic benefits; the extrinsic ones may speak for themselves. PMID:25581089

  20. Advertising energy saving programs: The potential environmental cost of emphasizing monetary savings.

    PubMed

    Schwartz, Daniel; Bruine de Bruin, Wändi; Fischhoff, Baruch; Lave, Lester

    2015-06-01

    Many consumers have monetary or environmental motivations for saving energy. Indeed, saving energy produces both monetary benefits, by reducing energy bills, and environmental benefits, by reducing carbon footprints. We examined how consumers' willingness and reasons to enroll in energy-savings programs are affected by whether advertisements emphasize monetary benefits, environmental benefits, or both. From a normative perspective, having 2 noteworthy kinds of benefit should not decrease a program's attractiveness. In contrast, psychological research suggests that adding external incentives to an intrinsically motivating task may backfire. To date, however, it remains unclear whether this is the case when both extrinsic and intrinsic motivations are inherent to the task, as with energy savings, and whether removing explicit mention of extrinsic motivation will reduce its importance. We found that emphasizing a program's monetary benefits reduced participants' willingness to enroll. In addition, participants' explanations about enrollment revealed less attention to environmental concerns when programs emphasized monetary savings, even when environmental savings were also emphasized. We found equal attention to monetary motivations in all conditions, revealing an asymmetric attention to monetary and environmental motives. These results also provide practical guidance regarding the positioning of energy-saving programs: emphasize intrinsic benefits; the extrinsic ones may speak for themselves.

  1. Development of an Energy-Savings Calculation Methodology for Residential Miscellaneous Electric Loads: Preprint

    SciTech Connect

    Hendron, R.; Eastment, M.

    2006-08-01

    In order to meet whole-house energy savings targets beyond 50% in residential buildings, it will be essential that new technologies and systems approaches be developed to address miscellaneous electric loads (MELs). These MELs are comprised of the small and diverse collection of energy-consuming devices found in homes, including what are commonly known as plug loads (televisions, stereos, microwaves), along with all hard-wired loads that do not fit into other major end-use categories (doorbells, security systems, garage door openers). MELs present special challenges because their purchase and operation are largely under the control of the occupants. If no steps are taken to address MELs, they can constitute 40-50% of the remaining source energy use in homes that achieve 60-70% whole-house energy savings, and this percentage is likely to increase in the future as home electronics become even more sophisticated and their use becomes more widespread. Building America (BA), a U.S. Department of Energy research program that targets 50% energy savings by 2015 and 90% savings by 2025, has begun to identify and develop advanced solutions that can reduce MELs.

  2. Antioxidant and hepatoprotective activity of vitex honey against paracetamol induced liver damage in mice.

    PubMed

    Wang, Yuan; Li, Dan; Cheng, Ni; Gao, Hui; Xue, Xiaofeng; Cao, Wei; Sun, Liping

    2015-07-01

    Fourteen vitex honeys from China were investigated to evaluate its antioxidant and hepatoprotective activity against paracetamol-induced liver damage. All honey samples exhibited high total phenolic content (344-520 mg GAE per kg), total flavonoid content (19-31 mg Rutin per kg), and strong antioxidant activity in DPPH radical scavenging, ferric reducing antioxidant power and Ferrous ion-chelating ability. Nine phenolic acids were detected in vitex honey samples, in which caffeic acid was the main compound. Honey from Heibei Zanhuang (S2) ranked the highest antioxidant activity was orally administered to mice (5 g kg(-1), 20 g kg(-1)) for 70 days. In high-dose (20 g kg(-1)), vitex honey pretreatment resulting in significant increase in serum oxygen radical absorbance capacity (15.07%) and decrease in Cu(2+)-mediate lipoprotein oxidation (80.07%), and suppression in alanine aminotransferase (75.79%) and aspartate aminotransferase (74.52%), enhancement in the superoxide dismutase and glutathione peroxidase activities and reduction in malondialdehyde (36.15%) and 8-hydroxy-2'-deoxyguanosine (19.6%) formation compared with paracetamol-intoxicated group. The results demonstrated the hepatoprotection of vitex honey against paracetamol-induced liver damage might attribute to its antioxidant and/or perhaps pro-oxidative property. PMID:26084988

  3. Antioxidant and hepatoprotective activity of vitex honey against paracetamol induced liver damage in mice.

    PubMed

    Wang, Yuan; Li, Dan; Cheng, Ni; Gao, Hui; Xue, Xiaofeng; Cao, Wei; Sun, Liping

    2015-07-01

    Fourteen vitex honeys from China were investigated to evaluate its antioxidant and hepatoprotective activity against paracetamol-induced liver damage. All honey samples exhibited high total phenolic content (344-520 mg GAE per kg), total flavonoid content (19-31 mg Rutin per kg), and strong antioxidant activity in DPPH radical scavenging, ferric reducing antioxidant power and Ferrous ion-chelating ability. Nine phenolic acids were detected in vitex honey samples, in which caffeic acid was the main compound. Honey from Heibei Zanhuang (S2) ranked the highest antioxidant activity was orally administered to mice (5 g kg(-1), 20 g kg(-1)) for 70 days. In high-dose (20 g kg(-1)), vitex honey pretreatment resulting in significant increase in serum oxygen radical absorbance capacity (15.07%) and decrease in Cu(2+)-mediate lipoprotein oxidation (80.07%), and suppression in alanine aminotransferase (75.79%) and aspartate aminotransferase (74.52%), enhancement in the superoxide dismutase and glutathione peroxidase activities and reduction in malondialdehyde (36.15%) and 8-hydroxy-2'-deoxyguanosine (19.6%) formation compared with paracetamol-intoxicated group. The results demonstrated the hepatoprotection of vitex honey against paracetamol-induced liver damage might attribute to its antioxidant and/or perhaps pro-oxidative property.

  4. Antioxidant and hepatoprotective potential of Pouteria campechiana on acetaminophen-induced hepatic toxicity in rats.

    PubMed

    Aseervatham, G Smilin Bell; Sivasudha, T; Sasikumar, J M; Christabel, P Hephzibah; Jeyadevi, R; Ananth, D Arul

    2014-03-01

    Pouteria campechiana (Kunth) Baehni. is used as a remedy for coronary trouble, liver disorders, epilepsy, skin disease, and ulcer. Therefore, the present study aims to investigate the antioxidant and hepatoprotective effect of polyphenolic-rich P. campechiana fruit extract against acetaminophen-intoxicated rats. Total phenolic and flavonoid contents of egg fruit were estimated followed by the determination of antioxidant activities. Treatment with P. campechiana fruit extract effectively scavenged the free radicals in a concentration-dependent manner within the range of the given concentrations in all antioxidant models. The presence of polyphenolic compounds were confirmed by high-performance thin-layer chromatography (HPTLC). The animals were treated with acetaminophen (250 mg/kg body weight; p.o.) thrice at the interval of every 5 days after the administration of P. campechiana aqueous extract and silymarin (50 mg/kg). Acetaminophen treatment was found to trigger an oxidative stress in liver, leading to an increase of serum marker enzymes. However, treatment with P. campechiana fruit extract significantly reduced the elevated liver marker enzymes (aspartate transaminase, alanine transaminase, and alkaline phosphatase) and increased the antioxidant enzymes (viz., superoxide dismutase and catalase) and glutathione indicating the effect of the extract in restoring the normal functional ability of hepatocytes. These results strongly suggest that P. campechiana fruit extract has strong antioxidant and significant hepatoprotective effect against acetaminophen-induced hepatotoxicity.

  5. Hepatoprotective and anti-oxidant activities of Glossogyne tenuifolia against acetaminophen-induced hepatotoxicity in mice.

    PubMed

    Tien, Yu-Hsiu; Chen, Bing-Huei; Wang Hsu, Guoo-Shyng; Lin, Wan-Teng; Huang, Jui-Hua; Lu, Yi-Fa

    2014-01-01

    The present study investigated the anti-oxidative and hepatoprotective effects of Glossogyne tenuifolia (GT) Cassini, against acetaminophen-induced acute liver injury in BALB/c mice. The extracts of GT by various solvents (hot water, 50% ethanol and 95% ethanol) were compared for their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, reducing power, total phenolic content, and total anti-oxidant capacity. The results showed that hot water (HW) extracts of GT contained high levels of phenolics and exerted an excellent anti-oxidative capacity; thus, these were used in the animal experiment. The male BALB/c mice were randomly divided into control group, acetaminophen (APAP) group, positive control group and two GT groups at low (GT-L) and high (GT-H) dosages. The results showed that mice treated with GT had significantly decreased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). GT-H increased glutathione levels and the ratios of reduced glutathione and oxidized glutathione (GSH/GSSG) in the liver, and inhibited serum and lipid peroxidation. This experiment was the first to determine phenolic compounds, chlorogenic acid and luteolin-7-glucoside in HW extract of GT. In conclusion, HW extract of GT may have potential anti-oxidant capacity and show hepatoprotective capacities in APAP-induced liver damaged mice.

  6. Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara

    PubMed Central

    Ramnath, Madhusudhanan Gogul; Thirugnanasampandan, Ramaraj; Mathusalini, Sadasivam; Mohan, Palathurai Subramanium

    2016-01-01

    Isodon (Lamiaceae) is a known source of bioactive terpenoids. Diterpenoids isolated from Isodon wightii (Bentham) H. Hara showed antibacterial, antiacetylcholinesterase, antioxidant, anticancer, and anticarcinogenic activities, etc., Hepatoprotective activity of ABA against lipopolysaccharide (LPS) induced liver injury in BALB/c mice was studied. Cytotoxic activity of ABA was tested against cervical cancer cells (HeLa) using MTT assay followed by propidium iodide (PI) staining to identify apoptosis. Histopathological analysis revealed that 1.5 ॖg/mL LPS induced liver damage was attenuated by ABA in a dose dependent manner. ABA showed cytotoxicity with IC50 value of 176.28 ± 0.02 ॖg/mL and PI staining of treated cells showed apoptosis. This study proves that ABA would be a promising natural compound for herbal drug preparation. SUMMARY In the present study, abietic acid isolated from I. wightii had potent hepatoprotective effect on LPS induced liver damage in BALB/c mice. Abietic acid also showed cytotoxic activity on HeLa cells followed by apoptosis induction confirmed by PI staining. Abbreviation Used: ABA: Abietic acid; LPS: Lipopolysacharride; PBS: Phosphate buffer saline; PI: Propidium iodide; NMR: Nuclear magnetic resonance; COSY: Correlation spectroscopy; HSQC: Heteronuclear single quantum correlation; HMBC: Heteronuclear multi - bond correlation; MTT: 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide PMID:27365991

  7. Hepatoprotective Effect of Opuntia robusta and Opuntia streptacantha Fruits against Acetaminophen-Induced Acute Liver Damage

    PubMed Central

    González-Ponce, Herson Antonio; Martínez-Saldaña, María Consolación; Rincón-Sánchez, Ana Rosa; Sumaya-Martínez, María Teresa; Buist-Homan, Manon; Faber, Klaas Nico; Moshage, Han; Jaramillo-Juárez, Fernando

    2016-01-01

    Acetaminophen (APAP)-induced acute liver failure (ALF) is a serious health problem in developed countries. N-acetyl-l-cysteine (NAC), the current therapy for APAP-induced ALF, is not always effective, and liver transplantation is often needed. Opuntia spp. fruits are an important source of nutrients and contain high levels of bioactive compounds, including antioxidants. The aim of this study was to evaluate the hepatoprotective effect of Opuntia robusta and Opuntia streptacantha extracts against APAP-induced ALF. In addition, we analyzed the antioxidant activities of these extracts. Fruit extracts (800 mg/kg/day, orally) were given prophylactically to male Wistar rats before intoxication with APAP (500 mg/kg, intraperitoneally). Rat hepatocyte cultures were exposed to 20 mmol/L APAP, and necrosis was assessed by LDH leakage. Opuntia robusta had significantly higher levels of antioxidants than Opuntia streptacantha. Both extracts significantly attenuated APAP-induced injury markers AST, ALT and ALP and improved liver histology. The Opuntia extracts reversed APAP-induced depletion of liver GSH and glycogen stores. In cultured hepatocytes, Opuntia extracts significantly reduced leakage of LDH and cell necrosis, both prophylactically and therapeutically. Both extracts appeared to be superior to NAC when used therapeutically. We conclude that Opuntia extracts are hepatoprotective and can be used as a nutraceutical to prevent ALF. PMID:27782042

  8. Hepatoprotective and anti-oxidant activities of Glossogyne tenuifolia against acetaminophen-induced hepatotoxicity in mice.

    PubMed

    Tien, Yu-Hsiu; Chen, Bing-Huei; Wang Hsu, Guoo-Shyng; Lin, Wan-Teng; Huang, Jui-Hua; Lu, Yi-Fa

    2014-01-01

    The present study investigated the anti-oxidative and hepatoprotective effects of Glossogyne tenuifolia (GT) Cassini, against acetaminophen-induced acute liver injury in BALB/c mice. The extracts of GT by various solvents (hot water, 50% ethanol and 95% ethanol) were compared for their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, reducing power, total phenolic content, and total anti-oxidant capacity. The results showed that hot water (HW) extracts of GT contained high levels of phenolics and exerted an excellent anti-oxidative capacity; thus, these were used in the animal experiment. The male BALB/c mice were randomly divided into control group, acetaminophen (APAP) group, positive control group and two GT groups at low (GT-L) and high (GT-H) dosages. The results showed that mice treated with GT had significantly decreased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). GT-H increased glutathione levels and the ratios of reduced glutathione and oxidized glutathione (GSH/GSSG) in the liver, and inhibited serum and lipid peroxidation. This experiment was the first to determine phenolic compounds, chlorogenic acid and luteolin-7-glucoside in HW extract of GT. In conclusion, HW extract of GT may have potential anti-oxidant capacity and show hepatoprotective capacities in APAP-induced liver damaged mice. PMID:25384447

  9. Bioassay-guided fractionation of a hepatoprotective and antioxidant extract of pea by-product.

    PubMed

    Seida, Ahmed A; El Tanbouly, Nebal D; Islam, Wafaa T; Eid, Hanaa H; El Maraghy, Shohda A; El Senousy, Amira S

    2015-01-01

    The hepatoprotective and antioxidant activities of the hydroalcoholic extract (PE) of pea (Pisum sativum L.) by-product were evaluated, using CCl4-induced oxidative stress and hepatic damage in rats. These activities were assessed via measuring alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein and albumin, malondialdehyde (MDA), reduced glutathione (GSH), protein thiols (PSH), nitrite/nitrate levels, glutathione-peroxidase (GSH-Px), glutathione-S-transferase (GST) activities, as well as, histopathological evaluation. PE revealed significant hepatoprotective and antioxidant activities mostly found in n-butanol fraction. Chromatographic fractionation of this active fraction led to the isolation of five flavonoid glycosides namely, quercetin-3-O-sophorotrioside (1), quercetin-3-O-rutinoside (2), quercetin-3-O-(6″″-O-E sinapoyl)-sophorotrioside (3), quercetin-3-O-(6″″-O-E feruloyl)-sophorotrioside (4) and quercetin-3-O-β-D-glucopyranoside (5). The isolated compounds were quantified in PE, using a validated HPLC method and the nutritional composition of pea by-product was also investigated. Our results suggest that pea by-product contained biologically active constituents which can be utilised to obtain high value added products for nutraceutical use.

  10. Using Revolving Loan Funds to Finance Energy Savings Performance Contracts in State and Local Agency Applications (Revised)

    SciTech Connect

    Booth, S.; Doris, E.; Knutson, D.; Regenthal, S.

    2011-07-01

    This document is meant to assist state and local decision makers in understanding how the financing of energy savings performance contract projects can effectively fit into the structure of a revolving loan fund.

  11. Antioxidant and hepatoprotective activity of Hamelia patens extracts.

    PubMed

    Perez-Meseguer, Jonathan; Delgado-Montemayor, Cecilia; Ortíz-Torres, Tania; Salazar-Aranda, Ricardo; Cordero-Perez, Paula; de Torres, Noemí Waksman

    2016-01-01

    Hamelia patens is widely used in the traditional medicine of Mexico and Central America for the treatment of illnesses associated with inflammatory processes. In this study, antioxidant and hepatoprotective activity were assayed on the methanolic crude (ME), hexane (HE), ethyl acetate (AE), and butanol (BE) extracts of H. patens. The total phenolic content (TPC) as mg of gallic acid equivalents per g of dry extract was determined by Folin-Ciocalteu's method (ME=141.58±11.99, HE=33.96±1.13, AE=375.18±13.09, BE=132.08±3.62), and antioxidant activity by 2,2-diphenyl-1-picryl-hydrazyl (DPPH) free radical-scavenging method (EC(50) ME=77.87±5.67, HE=236.64±26.32, AE=45.87±2.24, BE=50.97±0.85μg/mL). Hepatoprotective activity was evaluated through AST activity on HepG2 cells subjected to damage with CCl(4) (ME=62.5±3.41, HE=72.25±2.87, AE=63.50±4.20, BE=43.74±4.03). BE showed the greater hepatoprotective activity and a good antioxidant capacity, while HE did not show hepatoprotective or antioxidant activity. Cytotoxicity was evaluated on Vero cells cultures; none showed significant toxicity.

  12. Hepatoprotective activity of Mammea africana ethanol stem bark extract

    PubMed Central

    Okokon, Jude Efiom; Bawo, Michael Burata; Mbagwu, Herbert Orji

    2016-01-01

    Objective: The stem bark of Mammea africana Sabine (Guttiferae), (M. africana) a common plant that has been traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol-induced liver injury in rats. Materials and Methods: The hepatoprotective effect of the stem bark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), and alkaline phosphatase activities (ALP), antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and histopathological study of the liver. Results: Administration of the stem bark extract caused a significant (p<0.05 – 0.001) dose-dependent reduction of high levels of liver enzymes (ALT, AST and ALP), total cholesterol, direct and total bilirubin as well as elevation of serum levels of total protein, albumin and antioxidant enzymes (SOD, CAT, GPx and GSH). Histology of the liver sections of extract and silymarin-treated animals showed reductions in the pathological features compared to the paracetamol-treated animals. The chemical pathological changes were consistent with histopathological observations suggesting marked hepatoprotective effect of the stem bark extract of M. africana. Conclusion: The results show that the stem bark extract of M. africana has hepatoprotective potential which may be due to its antioxidant activity. PMID:27222838

  13. Evaluation of hepatoprotective activity of the commerson's anchovy (Stolephorus commersonnii)

    PubMed Central

    Varkey, Jeffy A.; Vahab, A. Abdul

    2016-01-01

    Objective: In the present study, we have chosen a fish Stolephorus commersonnii which is abundant in whitebait catches along Kerala coast. This fish is reported to contain higher content of essential amino acids, monounsaturated fatty acids, polyunsaturated fatty acids and minerals. The medicinal values of this species have not been reported and remain unexplored. Hence, there is a necessity to explore their uses and to conduct the pharmacological studies to ascertain their therapeutic properties. Based on literature search, no study has been carried out to scientifically validate the fish S. commersonnii possesses hepatoprotective property. Hence, this study was carried out to investigate the hepatoprotective effect of the S. commersonnii. Materials and Methods: The fish was purchased from the fish market, Ernakulam, Kerala, India. The fish were kept on ice until processed in the lab. Fish is washed and cleaned properly. The tissue is homogenized and extracted with chloroform: methanol solvent system. The extract is transferred to a dark glass container and stored in a freezer. The preliminary analysis of fish extract was carried out by simple qualitative methods. The hepatoprotective activity of Stolephorus commersonnii (SC) extract at 300 mg/kg is carried out in isoniazid induced hepatotoxic model. The albino rats of either sex were used for these studies. Results: The results of hepatoprotective study revealed that the SC extract showed a liver protective action against isoniazid induced toxicity. Conclusion: The present study suggests that the extract of S. commersonnii fish has therapeutic potential in the management of drug induced liver toxicity. PMID:26997726

  14. Enolate-Forming Phloretin Pharmacophores: Hepatoprotection in an Experimental Model of Drug-Induced Toxicity.

    PubMed

    Geohagen, Brian C; Vydyanathan, Amaresh; Kosharskyy, Boleslav; Shaparin, Naum; Gavin, Terrence; LoPachin, Richard M

    2016-06-01

    Drug-induced toxicity is often mediated by electrophilic metabolites, such as bioactivation of acetaminophen (APAP) to N-acetyl-p-benzoquinone imine (NAPQI). We have shown that APAP hepatotoxicity can be prevented by 2-acetylcyclopentanone (2-ACP). This 1,3-dicarbonyl compound ionizes to form an enolate nucleophile that scavenges NAPQI and other electrophilic intermediates. In this study, we expanded our investigation of enolate-forming compounds to include analyses of the phloretin pharmacophores, 2',4',6'-trihydroxyacetophenone (THA) and phloroglucinol (PG). Studies in a mouse model of APAP overdose showed that THA provided hepatoprotection when given either by intraperitoneal injection or oral administration, whereas PG was hepatoprotective only when given intraperitoneally. Corroborative research characterized the molecular pharmacology (efficacy, potency) of 2-ACP, THA, and PG in APAP-exposed isolated mouse hepatocytes. For comparative purposes, N-acetylcysteine (NAC) cytoprotection was also evaluated. Measurements of multiple cell parameters (e.g., cell viability, mitochondrial membrane depolarization) indicated that THA and, to a lesser extent, PG provided concentration-dependent protection against APAP toxicity, which exceeded that of 2-ACP or NAC. The enolate-forming compounds and NAC truncated ongoing APAP exposure and thereby returned intoxicated hepatocytes toward normal viability. The superior ability of THA to protect is related to multifaceted modes of action that include metal ion chelation, free radical trapping, and scavenging of NAPQI and other soft electrophiles involved in oxidative stress. The rank order of potency for the tested cytoprotectants was consistent with that determined in a parallel mouse model. These data suggest that THA or a derivative might be useful in treating drug-induced toxicities and other conditions that involve electrophile-mediated pathogenesis. PMID:27029584

  15. Energy-saving scheme based on downstream packet scheduling in ethernet passive optical networks

    NASA Astrophysics Data System (ADS)

    Zhang, Lincong; Liu, Yejun; Guo, Lei; Gong, Xiaoxue

    2013-03-01

    With increasing network sizes, the energy consumption of Passive Optical Networks (PONs) has grown significantly. Therefore, it is important to design effective energy-saving schemes in PONs. Generally, energy-saving schemes have focused on sleeping the low-loaded Optical Network Units (ONUs), which tends to bring large packet delays. Further, the traditional ONU sleep modes are not capable of sleeping the transmitter and receiver independently, though they are not required to transmit or receive packets. Clearly, this approach contributes to wasted energy. Thus, in this paper, we propose an Energy-Saving scheme that is based on downstream Packet Scheduling (ESPS) in Ethernet PON (EPON). First, we design both an algorithm and a rule for downstream packet scheduling at the inter- and intra-ONU levels, respectively, to reduce the downstream packet delay. After that, we propose a hybrid sleep mode that contains not only ONU deep sleep mode but also independent sleep modes for the transmitter and the receiver. This ensures that the energy consumed by the ONUs is minimal. To realize the hybrid sleep mode, a modified GATE control message is designed that involves 10 time points for sleep processes. In ESPS, the 10 time points are calculated according to the allocated bandwidths in both the upstream and the downstream. The simulation results show that ESPS outperforms traditional Upstream Centric Scheduling (UCS) scheme in terms of energy consumption and the average delay for both real-time and non-real-time packets downstream. The simulation results also show that the average energy consumption of each ONU in larger-sized networks is less than that in smaller-sized networks; hence, our ESPS is better suited for larger-sized networks.

  16. Energy Saving Melting and Revert Reduction Technology (E-SMARRT): Design Support for Tooling Optimization

    SciTech Connect

    Wang, Dongtao

    2011-09-23

    High pressure die casting is an intrinsically efficient net shape process and improvements in energy efficiency are strongly dependent on design and process improvements that reduce scrap rates so that more of the total consumed energy goes into acceptable, usable castings. Computer simulation has become widely used within the industry but use is not universal. Further, many key design decisions must be made before the simulation can be run and expense in terms of money and time often limits the number of decision iterations that can be explored. This work continues several years of work creating simple, very fast, design tools that can assist with the early stage design decisions so that the benefits of simulation can be maximized and, more importantly, so that the chances of first shot success are maximized. First shot success and better running processes contributes to less scrap and significantly better energy utilization by the process. This new technology was predicted to result in an average energy savings of 1.83 trillion BTUs/year over a 10 year period. Current (2011) annual energy saving estimates over a ten year period, based on commercial introduction in 2012, a market penetration of 30% by 2015 is 1.89 trillion BTUs/year by 2022. Along with these energy savings, reduction of scrap and improvement in yield will result in a reduction of the environmental emissions associated with the melting and pouring of the metal which will be saved as a result of this technology. The average annual estimate of CO2 reduction per year through 2022 is 0.037 Million Metric Tons of Carbon Equivalent (MM TCE).

  17. Measured energy savings of light colored roofs: Results from three California demonstration sites

    SciTech Connect

    Akbari, H.; Gartland, L.; Konopacki, S.

    1998-06-01

    Measured data and computer simulations have demonstrated the impact of roof albedo in reducing cooling energy use in buildings. Savings are a function of both climate and the amount of roof insulation. The cooling energy savings for reflective roofs are highest in hot climates. A reflective roof may also lead to higher heating energy use. Reflective coatings are also used in commercial buildings to protect the roofing membrane, and hence, maintain and prolong the useful life of the roof. Reflectivity of coatings changes with weathering and aging which in turn could have an effect on building cooling-energy savings. For that reason, reflective roof coatings are not primarily marketed for their energy savings potential. To monitor the field performance of reflective coatings, the authors initiated a demonstration project where three commercial buildings in California were painted with light-colored roof coatings. The buildings are two medical care centers and one drug store. At all sites, the roof reflectance, both fresh and aged, and cooling energy use were monitored. In addition, they measured temperature throughout the roof systems and inside the conditioned space. In the monitored buildings, increasing the roof reflectance from an initial value of about 20% to 60%, dropped the roof temperature on hot summer afternoons by about 45 F. Summertime standard-weekday average daily air-conditioning savings were 18% (198 kWh) in the first medical office building, 13% (86 kWh) in the second medical office building, and 2% (13 kWh) in the drug store. The overall u-value of the roofs had dictated the impact of roof reflectance.

  18. Energy savings opportunity study, Energy Engineering Analysis Program, Fort Dix, New Jersey, executive summary. Final report

    SciTech Connect

    1988-07-01

    In October of 1985, the firm of Einhorn Yaffee Prescott, P.C. was retained by the Army Corps of Engineers to perform an energy savings opportunity survey of 63 buildings at Fort Dix, New Jersey. The scope of this study included the following work: Evaluate selected energy conservation opportunities (ECO`s) to determine their energy savings potential and economic feasibility. Perform a limited site survey of selected buildings or areas to insure that any new methods of energy conservation which are practical and have not been evaluated in any previous energy study have been considered and the results documented. Provide complete new programming or implementation documentation for all recommended ECO`s. Prepare a comprehensive report to document the work performed, the results and the recommendations. With this prefinal submittal approximately 95 percent of the work required by the scope has been completed. The Executive Summary contains the following material: A brief description of previous energy efforts at Fort Dix and the way this survey was conducted. Graphical Energy History. Chart of recommended projects with economic justification. A brief description of each component ECO in the individual projects with economic summaries. For a more comprehensive treatment of the results of this ESOS refer to the five volume Narrative Report. These volumes deal with the physical characteristics of each of the sixty three buildings surveyed, their apparent deficiencies, the ECOs studied and recommended to improve their energy Perfermance. Included in this work is an energy savings calculation for each researched ECO with associated ECIP life cycle economics. The ten recommended projects have been included in the programming docu ments where a form DD 1391 has been prepared for each along with a 1391 for each individual ECO within the project.

  19. Energy-Saving Melting and Revert Reduction Technology (E-SMARRT): Final Summary Report

    SciTech Connect

    White, Thornton C

    2014-03-31

    Energy-Saving Melting and Revert Reduction Technology (E-SMARRT) is a balanced portfolio of R&D tasks that address energy-saving opportunities in the metalcasting industry. E-SMARRT was created to: • Improve important capabilities of castings • Reduce carbon footprint of the foundry industry • Develop new job opportunities in manufacturing • Significantly reduce metalcasting process energy consumption and includes R&D in the areas of: • Improvements in Melting Efficiency • Innovative Casting Processes for Yield Improvement/Revert Reduction • Instrumentation and Control Improvement • Material properties for Casting or Tooling Design Improvement The energy savings and process improvements developed under E-SMARRT have been made possible through the unique collaborative structure of the E-SMARRT partnership. The E-SMARRT team consisted of DOE’s Office of Industrial Technology, the three leading metalcasting technical associations in the U.S: the American Foundry Society; the North American Die Casting Association; and the Steel Founders’ Society of America; and SCRA Applied R&D, doing business as the Advanced Technology Institute (ATI), a recognized leader in distributed technology management. This team provided collaborative leadership to a complex industry composed of approximately 2,000 companies, 80% of which employ less than 100 people, and only 4% of which employ more than 250 people. Without collaboration, these new processes and technologies that enable energy efficiencies and environment-friendly improvements would have been slow to develop and had trouble obtaining a broad application. The E-SMARRT R&D tasks featured low-threshold energy efficiency improvements that are attractive to the domestic industry because they do not require major capital investment. The results of this portfolio of projects are significantly reducing metalcasting process energy consumption while improving the important capabilities of metalcastings. Through June

  20. Optimizing Energy Savings from Direct-DC in U.S. Residential Buildings

    SciTech Connect

    Garbesi, Karina; Vossos, Vagelis; Sanstad, Alan; Burch, Gabriel

    2011-10-13

    An increasing number of energy efficient appliances operate on direct current (DC) internally, offering the potential to use DC from renewable energy systems directly and avoiding the losses inherent in converting power to alternating current (AC) and back. This paper investigates that potential for net-metered residences with on-site photovoltaics (PV) by modeling the net power draw of the ‘direct-DC house’ with respect to today’s typical configuration, assuming identical DC-internal loads. Power draws were modeled for houses in 14 U.S. cities, using hourly, simulated PV-system output and residential loads. The latter were adjusted to reflect a 33% load reduction, representative of the most efficient DC-internal technology, based on an analysis of 32 electricity end-uses. The model tested the effect of climate, electric vehicle (EV) loads, electricity storage, and load shifting on electricity savings; a sensitivity analysis was conducted to determine how future changes in the efficiencies of power system components might affect savings potential. Based on this work, we estimate that net-metered PV residences could save 5% of their total electricity load for houses without storage and 14% for houses with storage. Based on residential PV penetration projections for year 2035 obtained from the National Energy Modeling System (2.7% for the reference case and 11.2% for the extended policy case), direct-DC could save the nation 10 trillion Btu (without storage) or 40 trillion Btu (with storage). Shifting the cooling load by two hours earlier in the day (pre-cooling) has negligible benefits for energy savings. Direct-DC provides no energy savings benefits for EV charging, to the extent that charging occurs at night. However, if charging occurred during the day, for example with employees charging while at work, the benefits would be large. Direct-DC energy savings are sensitive to power system and appliance conversion efficiencies but are not significantly

  1. Tillage energy savings from zone burial of shredded and whole cotton stalks

    SciTech Connect

    Carter, L.; Chesson, J.; Thacker, G.; Penner, V.

    1996-04-01

    Two prototypes of a stalk burial implement were tested for energy requirements at the University of California, Shafter Research Station. Both versions of the implement are designed to bury the cotton stalks in a concentrated Zone and reform the bed in the same location. To plow under shredded stalks, both versions of the implement required less energy than a conventional tillage systems typical of the San Joaquin Valley of California. Both stalk burial implements were also used to plow under whole cotton stalks. This offers additional energy savings by eliminating the stalk shredding operation.

  2. Energy Savings Potential and Opportunities for High-Efficiency Electric Motors in Residential and Commercial Equipment

    SciTech Connect

    Goetzler, William; Sutherland, Timothy; Reis, Callie

    2013-12-04

    This report describes the current state of motor technology and estimates opportunities for energy savings through application of more advanced technologies in a variety of residential and commercial end uses. The objectives of this report were to characterize the state and type of motor technologies used in residential and commercial appliances and equipment and to identify opportunities to reduce the energy consumption of electric motor-driven systems in the residential and commercial sectors through the use of advanced motor technologies. After analyzing the technical savings potential offered by motor upgrades and variable speed technologies, recommended actions are presented.

  3. Energy-saving technology of vector controlled induction motor based on the adaptive neuro-controller

    NASA Astrophysics Data System (ADS)

    Engel, E.; Kovalev, I. V.; Karandeev, D.

    2015-10-01

    The ongoing evolution of the power system towards a Smart Grid implies an important role of intelligent technologies, but poses strict requirements on their control schemes to preserve stability and controllability. This paper presents the adaptive neuro-controller for the vector control of induction motor within Smart Gird. The validity and effectiveness of the proposed energy-saving technology of vector controlled induction motor based on adaptive neuro-controller are verified by simulation results at different operating conditions over a wide speed range of induction motor.

  4. Benchmarking and Energy Saving Tool for Low Carbon Cities (BEST Cities)

    SciTech Connect

    2014-02-01

    BEST-Cities is designed to provide city authorities with strategies they can follow to reduce city-wide carbon dioxide (CO2) and methane (CH4) emissions. The tool quickly assesses local energy use and energy-related CO2 emissions across nine sectors (i.e., industry, public and commercial buildings, residential buildings, transportation, power and heat, street lighting, water & wastewater, solid waste, and urban green space), giving officials a comprehensive perspective on their local carbon performance. Cities can also use the tool to benchmark their energy and emissions performance to other cities inside and outside China, and identify those sectors with the greatest energy saving and emissions reduction potential.

  5. Protocol for Maximizing Energy Savings and Indoor Environmental Quality Improvements when Retrofiting Apartments

    SciTech Connect

    Noris, Federico; Delp, William W.; Vermeer, Kimberly; Adamkiewicz, Gary; Singer, Brett C.; Fisk, William J.

    2012-06-18

    The current focus on building energy retrofit provides an opportunity to simultaneously improve indoor environmental quality (IEQ). Toward this end, we developed a protocol for selecting packages of retrofits that both save energy and improve IEQ in apartments. The protocol specifies the methodology for selecting retrofits from a candidate list while addressing expected energy savings, IEQ impacts, and costs in an integrated manner. Interviews, inspections and measurements are specified to collect the needed input information. The protocol was applied to 17 apartments in three buildings in two different climates within California. Diagnostic measurements and surveys conducted before and after retrofit implementation indicate enhanced apartment performance.

  6. Energy Saving Strategies for the Use of Refractory Materials in Molten Material Contact

    SciTech Connect

    Hemrick, James Gordon; Peters, Klaus-Markus; Damiano, John

    2009-01-01

    Work was performed by Oak Ridge National Laboratory (ORNL), in collaboration with industrial refractory manufacturers, refractory users, and academic institutions, to employ novel refractory systems and techniques to reduce energy consumption of molten material processing vessels found in industries such as aluminum, glass and pulp and paper. The energy savings strategies discussed are achieved through reduction of chemical reactions, elimination of mechanical degradation caused by the service environment, reduction of temperature limitations of materials, and elimination of costly installation and repair needs. Key results of several case studies resulting from US Department of Energy (DOE) funded research programs are discussed with emphasis on applicability of these results to high temperature processing industries.

  7. Yield Improvement and Energy Savings Uing Phosphonates as Additives in Kraft pulping

    SciTech Connect

    Ulrike W. Tschirner; Timothy Smith

    2007-03-31

    Project Objective: Develop a commercially viable modification to the Kraft process resulting in energy savings, increased yield and improved bleachability. Evaluate the feasibility of this technology across a spectrum of wood species used in North America. Develop detailed fundamental understanding of the mechanism by which phosphonates improve KAPPA number and yield. Evaluate the North American market potential for the use of phosphonates in the Kraft pulping process. Examine determinants of customer perceived value and explore organizational and operational factors influencing attitudes and behaviors. Provide an economic feasibility assessment for the supply chain, both suppliers (chemical supply companies) and buyers (Kraft mills). Provide background to most effectively transfer this new technology to commercial mills.

  8. Protocol for maximizing energy savings and indoor environmental quality improvements when retrofitting apartments

    SciTech Connect

    Noris, Federico; Delp, William W.; Vermeer, Kimberly; Adamkiewicz, Gary; Singer, Brett C.; Fisk, William J.

    2013-06-01

    The current focus on building energy retrofit provides an opportunity to simultaneously improve indoor environmental quality (IEQ). Toward this end, we developed a protocol for selecting packages of retrofits that both save energy and improve IEQ in apartments. The protocol specifies the methodology for selecting retrofits from a candidate list while addressing expected energy savings, IEQ impacts, and costs in an integrated manner. Interviews, inspections and measurements are specified to collect the needed input information. The protocol was applied to 17 apartments in three buildings in two different climates within California. Diagnostic measurements and surveys conducted before and after retrofit implementation indicate enhanced apartment performance.

  9. Chiller Controls-related Energy Saving Opportunities in FederalFacilities

    SciTech Connect

    Webster, Tom

    2003-01-01

    Chillers are a significant component of large facility energy use. The focus of much of the development of chilled water systems in recent years has been on optimization of set point and staging controls, improvements in chiller design to increase efficiency and accommodate chlorofluorocarbon (CFC) refrigerant replacements. Other improvements have been made by upgrading controls to the latest digital technologies, improving access and monitoring via communications and sophisticated liquid crystal displays (LCD), more robust fault diagnostics and operating and maintenance information logging. Advances have also been made in how chiller plant systems are designed and operated, and in the diversity of chiller products that are available to support innovative approaches. As in many industries, these improvements have been facilitated by advances in, and lower costs for, enabling technologies, such as refrigerants, compressor design, electronics for controls and variable frequency drives (VFD). Along with the improvements in electronics one would expect that advances have also been made in the functionality of unit controls included with chillers. Originally, the primary purpose of this project was to investigate the state of practice of chiller unit controllers in terms of their energy saving capabilities. However, early in the study it was discovered that advances in this area did not include incorporation of significantly different capabilities than had existed 10-15 years ago. Thus the scope has been modified to provide an overview of some of the basic controls-related energy saving strategies that are currently available along with guideline estimates of their potential and applicability. We have minimized consideration of strategies that could be primarily implemented via design practices such as chiller selection and plant design, and those that can only be implemented by a building management system (BMS). Also, since most of the floor space of federal buildings

  10. Energy aspects and potential energy savings of the new DASI process for milk sterilization

    SciTech Connect

    Frey, B.C.; Stewart, L.E.; Chandarana, D.; Wolfson, R.P.

    1981-01-01

    An experimental study was conducted to determine the difference in total processing energy required by the DASI ultra-high temperature (UHT) system and a conventional high temperature short time (HTST) fluid milk system. Data available in the literature were used to develop an energy use profile for the current US fluid milk system from processor to consumer. The energy data measured and the profile developed were used to estimate the potential energy savings resulting from the introduction of sterile milk in the US fluid milk market. Savings of energy resulting from the introduction of sterile milk were estimated to be 12 million barrels of oil annually.

  11. Analysis of energy saving ability in dimming VLC systems using LEDs with optimized SAHP

    NASA Astrophysics Data System (ADS)

    Li, Fang; Wu, Kan; Zou, Weiwen; Chen, Jianping

    2016-02-01

    In this paper, we investigate the energy saving capability of dimming visible light communication (VLC) systems employing SC-4 PPM modulation scheme. We design different optimizations to maximize the energy efficiency according to the different illuminance efficiency with respect to LED's semi-angle at half power (SAHP) for four different LED alignments. Tradeoff between energy efficiency and signal-to-noise ratio (SNR) uniformity are also investigated to achieve better overall performance. The results show that more than 40% energy can be saved over the existing dimmed VLC system employing SC-4 PPM modulation scheme when optimized SAHP LEDs are used.

  12. Performance analysis of TCP traffic and its influence on ONU's energy saving in energy efficient TDM-PON

    NASA Astrophysics Data System (ADS)

    Alaelddin, Fuad Yousif Mohammed; Newaz, S. H. Shah; Lee, Joohyung; Uddin, Mohammad Rakib; Lee, Gyu Myoung; Choi, Jun Kyun

    2015-12-01

    The majority of the traffic over the Internet is TCP based, which is very sensitive to packet loss and delay. Existing research efforts in TDM-Passive Optical Networks (TDM-PONs) mostly evaluate energy saving and traffic delay performances under different energy saving solutions. However, to the best of our knowledge, how energy saving mechanisms could affect TCP traffic performance in TDM-PONs has hardly been studied. In this paper, by means of our state-of-art OPNET Modular based TDM-PON simulator, we evaluate TCP traffic delay, throughput, and Optical Network Unit (ONU) energy consumption performances in a TDM-PON where energy saving mechanisms are employed in ONUs. Here, we study the performances under commonly used energy saving mechanisms defined in standards for TDM-PONs: cyclic sleep and doze mode. In cyclic sleep mode, we evaluate the performances under two well-known sleep interval length deciding algorithms (i.e. fixed sleep interval (FSI) and exponential sleep interval deciding (ESID)) that an OLT uses to decide sleep interval lengths for an ONU. Findings in this paper put forward the strong relationship among TCP traffic delay, throughput and ONU energy consumption under different sleep interval lengths. Moreover, we reveal that under high TCP traffic, both FSI and ESID will end up showing similar delay, energy and throughput performance. Our findings also show that doze mode can offer better TCP throughput and delay performance at the price of consuming more energy than cyclic sleep mode. In addition, our results provide a glimpse on understanding at what point doze mode becomes futile in improving energy saving of an ONU under TCP traffic. Furthermore, in this paper, we highlight important research issues that should be studied in future research to maximize energy saving in TDM-PONs while meeting traffic Quality of Service requirements.

  13. Energy Savings From System Efficiency Improvements in Iowa's HVAC SAVE Program

    SciTech Connect

    Yee, S.; Baker, J.; Brand, L.; Wells, J.

    2013-08-01

    The objective of this project is to explore the energy savings potential of maximizing furnace and distribution system performance by adjusting operating, installation, and distribution conditions. The goal of the Iowa HVAC System Adjusted and Verified Efficiency (SAVE) program is to train contractors to measure installed system efficiency as a diagnostic tool to ensure that the homeowner achieves the energy reduction target for the home rather than simply performing a tune-up on the furnace or having a replacement furnace added to a leaky system. The PARR research team first examined baseline energy usage from a sample of 48 existing homes, before any repairs or adjustments were made, to calculate an average energy savings potential and to determine which system deficiencies were prevalent. The results of the baseline study of these homes found that, on average, about 10% of the space heating energy available from the furnace was not reaching the conditioned space. In the second part of the project, the team examined a sample of 10 homes that had completed the initial evaluation for more in-depth study. For these homes, the diagnostic data shows that it is possible to deliver up to 23% more energy from the furnace to the conditioned space by doing system tune ups with or without upgrading the furnace. Replacing the furnace provides additional energy reduction. The results support the author's belief that residential heating and cooling equipment should be tested and improved as a system rather than a collection of individual components.

  14. Energy-Saving Tunnel Illumination System Based on LED's Intelligent Control

    NASA Astrophysics Data System (ADS)

    Guo, Shanshan; Gu, Hanting; Wu, Lan; Jiang, Shuixiu

    2011-02-01

    At present there is a lot of electric energy wastage in tunnel illumination, whose design is based on the maximum brightness outside and the maximum vehicle speed all year round. LED's energy consumption is low, and the control of its brightness is simple and effective. It can be quickly adjusted between 0-100% of its maximum brightness, and will not affect the service life. Therefore, using LED as tunnel's illumination source, we can achieve a good energy saving effect. According to real-time data acquisition of vehicle speed, traffic flow and brightness outside the tunnel, the auto real-time control of tunnel illumination can be achieved. And the system regulated the LED luminance by means of combination of LED power module and intelligent control module. The tunnel information was detected by inspection equipments, which included luminometer, vehicle detector, and received by RTU(Remote Terminal Unit), then synchronously transmitted to PC. After data processing, RTU emitted the dimming signal to the LED driver to adjust the brightness of LED. Despite the relatively high cost of high-power LED lights, the enormous energy-saving effect and the well-behaved controllability is beyond compare to other lighting devices.

  15. Characteristics of energy savings in an ideal heat-integrated distillation column (HIDiC)

    SciTech Connect

    Nakaiwa, Masaru; Huang, Kejin; Owa, Masaru; Akiya, Takaji; Nakane, Takashi; Sato, Masahito; Takamatsu, Takeichiro

    1997-12-31

    Distillation columns are major energy consumers in the chemical and petrochemical industries. In order to reduce energy consumption, considerable studies have been carried out and many distillation columns have been proposed. A Heat-Integrated Distillation Column (HIDiC) is constructed in such a manner that its rectifying and stripping sections are separated, while connected through a compressor and a throttling valve. Separation is benefited by heat integration between the two sections. To provide the driving forces for heat transfers from the rectifying to the stripping sections, the former must be operated at higher pressure than the latter. The HIDiC is expected to be more energy efficient than conventional columns, while at the expenses of some energy to raise up the pressure of the rectifying section. In this paper, it is shown by thermodynamical consideration that the HIDiC has high potential of exergy loss reduction compared with conventional columns. The effects of pressure difference on energy saving are analyzed, and possibility of energy saving is found in some case studies.

  16. Measurement of Exterior Foundation Insulation to Assess Durability in Energy-Saving Performance

    SciTech Connect

    Kehrer, Manfred; Christian, Jeff

    2012-04-01

    The foundation of a house is a sometimes ignored component of the building because of its low visibility. It is increasingly evident, however, that attention to good foundation design and construction significantly benefits the homeowner and the builder by mitigating future problems. Good foundation design and construction practice involves not only insulating to save energy but also providing effective structural design as well as moisture, termite, and radon control techniques as appropriate. Energy efficiency in housing is augmented by use of exterior slab and basement insulation, but high moisture content in the insulation material has led to concerns about its durability. The activity under this task was to extract six different exterior insulation systems that were characterized at installation and have been in the ground for 9 months to 15 years. R-value and moisture content were measured and inspections conducted for evidence of termite intrusion or deterioration. Based on the results, the durability of the various systems has been documented and assessments made of which systems appear to be best practice. Heat flux and temperature measurement data had been archived for some of the exterior insulation tests, thereby providing a unique opportunity to assess energy-saving performance and durability over the long term. The results show that the durability of foundation insulation systems depends on insulation type as well as on foundation type and local boundary conditions, the latter of which may have a marked influence on the durability of energy-saving performance.

  17. Aerosol corrosion prevention and energy-saving strategies in the design of green data centers.

    PubMed

    Ferrero, Luca; Sangiorgi, Giorgia; Ferrini, Barbara S; Perrone, Maria G; Moscatelli, Marco; D'Angelo, Luca; Rovelli, Grazia; Ariatta, Alberto; Truccolo, Redy; Bolzacchini, Ezio

    2013-04-16

    The energy demands of data centers (DCs) worldwide are rapidly increasing, as are their environmental and economic costs. This paper presents a study conducted at Sannazzaro de' Burgondi (Po Valley), Italy, specifically aimed at optimizing the operating conditions of a DC designed for the Italian Oil and Gas Company (Eni) (5200 m(2) of Information Technology installed, 30 MW) and based on a direct free cooling (DFC) system. The aim of the study was to save the largest possible quantity of energy, while at the same time preventing aerosol corrosion. The aerosol properties (number size distribution, chemical composition, deliquescence relative humidity (DRH), acidity) and meteorological parameters were monitored and utilized to determine the potential levels of aerosol entering the DC (equivalent ISO class), together with its DRH. These data enabled us both to select the DC's filtering system (MERV13 filters) and to optimize the cooling cycle through calculation of the most reliable humidity cycle (60% of maximum allowed RH) applicable to the DFC. A potential energy saving of 81%, compared to a traditional air conditioning cooling system, was estimated: in one year, for 1 kW of installed information technology, the estimated energy saving is 7.4 MWh, resulting in 2.7 fewer tons of CO2 being emitted, and a financial saving of € 1100.

  18. Illumination performance and energy saving of a solar fiber optic lighting system.

    PubMed

    Lingfors, David; Volotinen, Tarja

    2013-07-01

    The illumination performance and energy savings of a solar fiber optic lighting system have been verified in a study hall--corridor interior. The system provides intensive white light with a high luminous flux of 4500 lm under 130000 lx direct sun radiation at a 10 m fiber distance from the sun-tracking light collector. The color temperature that describes the light color perceived is 5800 ± 300 K, i.e. close to the direct sunlight outside, and the color rendering index (86), that describes how well colors are rendered under the light source, is higher for the solar lights than for the supplementary fluorescent lights (77). Thus this high quality solar lighting improves the visibility of all kinds of objects compared to the fluorescent lights. Annual lighting energy savings of 19% in Uppsala, Sweden and 46% in southern Europe were estimated for a study hall interior, as well as 27% and 55% respectively in an interior illuminated 16 h per day all days of a year.

  19. Achieving Energy Savings with Highly-Controlled Lighting in an Open-Plan Office

    SciTech Connect

    Rubinstein, Francis; Enscoe, Abby

    2010-04-19

    An installation in a Federal building tested the effectiveness of a highly-controlled, workstation-specific lighting retrofit. The study took place in an open-office area with 86 cubicles and low levels of daylight. Each cubicle was illuminated by a direct/indirectpendant luminaire with three 32 watt lamps, two dimmable DALI ballasts, and an occupancy sensor. A centralized control system programmed all three lamps to turn on and off according to occupancy on a workstation-by-workstation basis. Field measurements taken over the course of several monthsdemonstrated 40% lighting energy savings compared to a baseline without advanced controls that conforms to GSA's current retrofit standard. A photometric analysis found that the installation provided higher desktop light levels than the baseline, while an occupant survey found that occupants in general preferred the lighting system to thebaseline.Simple payback is fairly high; projects that can achieve lower installation costs and/or higher energy savings and those in which greenhouse gas reduction and occupant satisfaction are significant priorities provide the ideal setting for workstation-specific lighting retrofits.

  20. Aerosol corrosion prevention and energy-saving strategies in the design of green data centers.

    PubMed

    Ferrero, Luca; Sangiorgi, Giorgia; Ferrini, Barbara S; Perrone, Maria G; Moscatelli, Marco; D'Angelo, Luca; Rovelli, Grazia; Ariatta, Alberto; Truccolo, Redy; Bolzacchini, Ezio

    2013-04-16

    The energy demands of data centers (DCs) worldwide are rapidly increasing, as are their environmental and economic costs. This paper presents a study conducted at Sannazzaro de' Burgondi (Po Valley), Italy, specifically aimed at optimizing the operating conditions of a DC designed for the Italian Oil and Gas Company (Eni) (5200 m(2) of Information Technology installed, 30 MW) and based on a direct free cooling (DFC) system. The aim of the study was to save the largest possible quantity of energy, while at the same time preventing aerosol corrosion. The aerosol properties (number size distribution, chemical composition, deliquescence relative humidity (DRH), acidity) and meteorological parameters were monitored and utilized to determine the potential levels of aerosol entering the DC (equivalent ISO class), together with its DRH. These data enabled us both to select the DC's filtering system (MERV13 filters) and to optimize the cooling cycle through calculation of the most reliable humidity cycle (60% of maximum allowed RH) applicable to the DFC. A potential energy saving of 81%, compared to a traditional air conditioning cooling system, was estimated: in one year, for 1 kW of installed information technology, the estimated energy saving is 7.4 MWh, resulting in 2.7 fewer tons of CO2 being emitted, and a financial saving of € 1100. PMID:23495934

  1. An Analysis of Energy Savings Possible Through Advances in Automotive Tooling Technology

    SciTech Connect

    Rick Schmoyer, RLS

    2004-12-03

    The use of lightweight and highly formable advanced materials in automobile and truck manufacturing has the potential to save fuel. Advances in tooling technology would promote the use of these materials. This report describes an energy savings analysis performed to approximate the potential fuel savings and consequential carbon-emission reductions that would be possible because of advances in tooling in the manufacturing of, in particular, non-powertrain components of passenger cars and heavy trucks. Separate energy analyses are performed for cars and heavy trucks. Heavy trucks are considered to be Class 7 and 8 trucks (trucks rated over 26,000 lbs gross vehicle weight). A critical input to the analysis is a set of estimates of the percentage reductions in weight and drag that could be achieved by the implementation of advanced materials, as a consequence of improved tooling technology, which were obtained by surveying tooling industry experts who attended a DOE Workshop, Tooling Technology for Low-Volume Vehicle Production, held in Seattle and Detroit in October and November 2003. The analysis is also based on 2001 fuel consumption totals and on energy-audit component proportions of fuel use due to drag, rolling resistance, and braking. The consumption proportions are assumed constant over time, but an allowance is made for fleet growth. The savings for a particular component is then the product of total fuel consumption, the percentage reduction of the component, and the energy audit component proportion. Fuel savings estimates for trucks also account for weight-limited versus volume-limited operations. Energy savings are assumed to be of two types: (1) direct energy savings incurred through reduced forces that must be overcome to move the vehicle or to slow it down in braking. and (2) indirect energy savings through reductions in the required engine power, the production and transmission of which incur thermodynamic losses, internal friction, and other

  2. Hepatoprotective activity of Annona muricata Linn. and Polyalthia cerasoides bedd.

    PubMed

    Padma, P; Chansouria, J P; Khosa, R L

    1999-07-01

    The hepatoprotective effect of Annona muricata and Polyalthia cerasoides (Annonaceae) were monitored by estimating the serum transaminases (SGOT and SGPT), serum alkaline phosphatase (SALP), liver and brain lipid peroxidation (LOP) and their total protein content. Both drugs at a dose of 100 μg/kg significantly prevented the increase in serum transaminases, SALP, liver and brain LOP and decrease in liver and brain total protein content following carbontetrachloride (CCl) induced hepatoxicity in albino rats.

  3. Targeting silymarin for improved hepatoprotective activity through chitosan nanoparticles

    PubMed Central

    Gupta, Swati; Singh, Shailendra Kumar; Girotra, Priti

    2014-01-01

    Introduction: Silymarin is one of the best known hepatoprotective drugs, which is obtained from the seeds of Silybum marianum L., Family: Asteraceae or Compositae. The plant has traditionally been used for centuries as a natural remedy for liver and biliary tract diseases. The aim of the present investigation was to enhance the hepatoprotective activity of silymarin by incorporating it in chitosan (Ch) nanoparticles (NPs) for passive targeted delivery, thereby prolonging its retention time. Materials and Methods: Silymarin loaded NPs were prepared by ionic gelation technique, which were then optimized using a central composite design in order to minimize the particle size and maximize the drug entrapment efficiency. The optimized formulation was evaluated for in vitro drug release study and in vitro study on Swiss Albino mice using carbon tetrachloride (CCL4) induced hepatotoxicity model. Results: In vitro dissolution studies illustrated sustained, zero order drug release from optimized formulation; also its therapeutic potential was amplified during in vitro studies on Swiss Albino mice using CCL4 induced hepatotoxicity model. Conclusion: The results suggested that NPs of silymarin could successfully enhance its hepatoprotective effect by passive targeting and sustained release. PMID:25426436

  4. Hepatoprotective activity of Achyrocline satureioides(Lam) D. C.

    PubMed

    Kadarian, C; Broussalis, A M; Miño, J; Lopez, P; Gorzalczany, S; Ferraro, G; Acevedo, C

    2002-01-01

    Aerial parts of Achyrocline satureioides(Lam) D. C. (Asteraceae) are used in folk medicine as infusions or decoctions for the management of several diseases including gastrointestinal and hepatic disorders. These data and the presence of flavonoids and caffeoyl derivatives have led us to study its hepatoprotective and choleretic activities. The hepatoprotective activity was evaluated in the bromobenzene- (BB-) induced hepatotoxicity model in mice through the measurement of the serum levels of alanine-aminotransferase (ALT) and aspartate transaminase (AST), thiobarbituric acid reacting substances (TBARS) and glutathione levels. The aqueous extract of the aerial parts of A. satureioides administered before BB, at the dose of 300 mg kg(-1)p.o., demonstrated significant inhibition (P< 0.01) in the BB increase of liver ALT and AST and in the BB-induced increase of liver TBARS content. Also it was able to significantly increase (P< 0.05) the depleted levels of liver glutathione. In addition, at the same dose, a significant increase (P< 0.01) in the bile flow of rats was found. The results obtained with the aqueous extract of A. satureioides support its use in popular medicine as a hepatoprotective and digestive agent, and the effects might be mediated through the antioxidant and choleretic activities.

  5. Empirical impact evaluation of the energy savings resulting from BPA's Stage II irrigation system retrofit program: Final report

    SciTech Connect

    Harrer, B.J.; Tawil, J.W.; Lyke, A.J.; Nieves, L.A.; Edin, E.S.; Bailey, B.M.

    1987-07-01

    This report documents the results of an evaluation of the impacts on irrigation system energy consumption of conservation measures installed under the Bonneville Power Administration's Stage II retrofit program. Historical billing data and other farm records provided the basis for this evaluation. A number of different statistical techniques were used to estimate the actual energy savings resulting from the Stage II conservation measures. Results of the study reveal that the methodology used in predicting energy savings resulting from the Stage II program is accurate. The basis for energy savings predictions in the Stage II program are changes in brake horsepower, and, in this study, a 1% change in brake horsepower was found to result in slightly more than a 1% change in energy consumption. Overall, Stage II program conservation measures were found to reduce irrigation system energy use by an average of 34%. The average costs of obtaining these savings were 6 mills (.6 cents) per kWh saved.

  6. Measured energy savings and performance of power-managed personal computers and monitors

    SciTech Connect

    Nordman, B.; Piette, M.A.; Kinney, K.

    1996-08-01

    Personal computers and monitors are estimated to use 14 billion kWh/year of electricity, with power management potentially saving $600 million/year by the year 2000. The effort to capture these savings is lead by the US Environmental Protection Agency`s Energy Star program, which specifies a 30W maximum demand for the computer and for the monitor when in a {open_quote}sleep{close_quote} or idle mode. In this paper the authors discuss measured energy use and estimated savings for power-managed (Energy Star compliant) PCs and monitors. They collected electricity use measurements of six power-managed PCs and monitors in their office and five from two other research projects. The devices are diverse in machine type, use patterns, and context. The analysis method estimates the time spent in each system operating mode (off, low-, and full-power) and combines these with real power measurements to derive hours of use per mode, energy use, and energy savings. Three schedules are explored in the {open_quotes}As-operated,{close_quotes} {open_quotes}Standardized,{close_quotes} and `Maximum` savings estimates. Energy savings are established by comparing the measurements to a baseline with power management disabled. As-operated energy savings for the eleven PCs and monitors ranged from zero to 75 kWh/year. Under the standard operating schedule (on 20% of nights and weekends), the savings are about 200 kWh/year. An audit of power management features and configurations for several dozen Energy Star machines found only 11% of CPU`s fully enabled and about two thirds of monitors were successfully power managed. The highest priority for greater power management savings is to enable monitors, as opposed to CPU`s, since they are generally easier to configure, less likely to interfere with system operation, and have greater savings. The difficulties in properly configuring PCs and monitors is the largest current barrier to achieving the savings potential from power management.

  7. Energy Savings Modeling of Standard Commercial Building Re-tuning Measures: Large Office Buildings

    SciTech Connect

    Fernandez, Nicholas; Katipamula, Srinivas; Wang, Weimin; Huang, Yunzhi; Liu, Guopeng

    2012-06-01

    Today, many large commercial buildings use sophisticated building automation systems (BASs) to manage a wide range of building equipment. While the capabilities of BASs have increased over time, many buildings still do not fully use the BAS's capabilities and are not properly commissioned, operated or maintained, which leads to inefficient operation, increased energy use, and reduced lifetimes of the equipment. This report investigates the energy savings potential of several common HVAC system retuning measures on a typical large office building prototype model, using the Department of Energy's building energy modeling software, EnergyPlus. The baseline prototype model uses roughly as much energy as an average large office building in existing building stock, but does not utilize any re-tuning measures. Individual re-tuning measures simulated against this baseline include automatic schedule adjustments, damper minimum flow adjustments, thermostat adjustments, as well as dynamic resets (set points that change continuously with building and/or outdoor conditions) to static pressure, supply air temperature, condenser water temperature, chilled and hot water temperature, and chilled and hot water differential pressure set points. Six combinations of these individual measures have been formulated - each designed to conform to limitations to implementation of certain individual measures that might exist in typical buildings. All of these measures and combinations were simulated in 16 cities representative of specific U.S. climate zones. The modeling results suggest that the most effective energy savings measures are those that affect the demand-side of the building (air-systems and schedules). Many of the demand-side individual measures were capable of reducing annual HVAC system energy consumption by over 20% in most cities that were modeled. Supply side measures affecting HVAC plant conditions were only modestly successful (less than 5% annual HVAC energy savings for

  8. Energy savings modelling of re-tuning energy conservation measures in large office buildings

    SciTech Connect

    Fernandez, Nick; Katipamula, Srinivas; Wang, Weimin; Huang, Yunzhi; Liu, Guopeng

    2014-10-20

    Today, many large commercial buildings use sophisticated building automation systems (BASs) to manage a wide range of building equipment. While the capabilities of BASs have increased over time, many buildings still do not fully use the BAS’s capabilities and are not properly commissioned, operated or maintained, which leads to inefficient operation, increased energy use, and reduced lifetimes of the equipment. This paper investigates the energy savings potential of several common HVAC system re-tuning measures on a typical large office building, using the Department of Energy’s building energy modeling software, EnergyPlus. The baseline prototype model uses roughly as much energy as an average large office building in existing building stock, but does not utilize any re-tuning measures. Individual re-tuning measures simulated against this baseline include automatic schedule adjustments, damper minimum flow adjustments, thermostat adjustments, as well as dynamic resets (set points that change continuously with building and/or outdoor conditions) to static pressure, supply-air temperature, condenser water temperature, chilled and hot water temperature, and chilled and hot water differential pressure set points. Six combinations of these individual measures have been formulated – each designed to conform to limitations to implementation of certain individual measures that might exist in typical buildings. All the individual measures and combinations were simulated in 16 climate locations representative of specific U.S. climate zones. The modeling results suggest that the most effective energy savings measures are those that affect the demand-side of the building (air-systems and schedules). Many of the demand-side individual measures were capable of reducing annual total HVAC system energy consumption by over 20% in most cities that were modeled. Supply side measures affecting HVAC plant conditions were only modestly successful (less than 5% annual HVAC energy

  9. Technical Support Document: Development of the Advanced Energy Design Guide for K-12 Schools--30% Energy Savings

    SciTech Connect

    Pless, S.; Torcellini, P.; Long, N.

    2007-09-01

    This Technical Support Document describes the process and methodology for the development of the Advanced Energy Design Guide for K-12 School Buildings (K-12 AEDG), a design guidance document intended to provide recommendations for achieving 30% energy savings in K-12 Schools over levels contained in ANSI/ASHRAE/IESNA Standard 90.1-1999, Energy Standard for Buildings Except Low-Rise Residential Buildings. The 30% energy savings target is the first step toward achieving net-zero energy schools; schools that, on an annual basis, draw from outside sources less or equal energy than they generate on site from renewable energy sources.

  10. Potent hepatoprotective effect in CCl4-induced hepatic injury in mice of phloroacetophenone from Myrcia multiflora

    PubMed Central

    Ferreira, Eduardo Antonio; Gris, Eliana Fortes; Felipe, Karina Bettega; Correia, João Francisco Gomes; Cargnin-Ferreira, Eduardo; Wilhelm Filho, Danilo; Pedrosa, Rozangela Curi

    2010-01-01

    Background This study investigated the hepatoprotective effect and antioxidant properties of phloroacetophenone (2′,4′,6′-trihydroxyacetophenone – THA), an acetophenone derived from the plant Myrcia multiflora. Material & Method The free radical scavenging activity in vitro and induction of oxidative hepatic damage by carbon tetrachloride (CCl4) (0.5 ml/kg, i.p.) were tested in male Swiss mice (25±5 g). Results This compound exhibited in vitro antioxidant effects on FeCl2–ascorbate-induced lipid peroxidation (LPO) in mouse liver homogenate, scavenging hydroxyl and superoxide radicals, and 2,2-diphenyl-1-picrylhydrazyl. The in vivo assays showed that THA significantly (p<0.01) prevented the increases of hepatic LPO as measured by the levels of thiobarbituric acid-reactive substances, mitochondrial swelling. It also protected hepatocytes against protein carbonylation and oxidative DNA damage. Consistent with these observations, THA pre-treatment normalized the activities of antioxidant enzymes, such as catalase, glutathione peroxidase, and superoxide dismutase, and increased the levels of reduced glutathione (GSH) in CCl4-treated mice. In addition, THA treatment significantly prevented the elevation of serum enzymatic activities of alanine amino transferase, aspartate amino transferase, and lactate dehydrogenase, as well as histological alterations induced by CCl4. Silymarin (SIL) (24 mg/kg), a known hepatoprotective drug used for comparison, led to a significant decrease (p<0.01) in activities of theses enzymes in way very similar to that observed in pre-treatment with THA. Conclusion These results suggest that the protective effects are due to reduction of oxidative damage induced by CCl4 resulting from the antioxidant properties of THA. PMID:21483585

  11. Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential

    PubMed Central

    2014-01-01

    Background Natural antioxidant products are increasingly being used to treat various pathological liver conditions considering the role of oxidative stress in their pathogenesis. Rosemary essential oil has already being used as a preservative in food industry due to its antioxidant and antimicrobial activities, but it was shown to possess additional health benefits. The aim of our study was to evaluate the protective effect of rosemary essential oil on carbon tetrachloride - induced liver injury in rats and to explore whether its mechanism of action is associated with modulation of hepatic oxidative status. Methods Chemical composition of isolated rosemary essential oil was determined by gas chromatography and mass spectrometry. Antioxidant activity was determined in vitro using DPPH assay. Activities of enzyme markers of hepatocellular damage in serum and antioxidant enzymes in the liver homogenates were measured using the kinetic spectrophotometric methods. Results In this research, we identified 29 chemical compounds of the studied rosemary essential oil, and the main constituents were 1,8-cineole (43.77%), camphor (12.53%), and α-pinene (11.51%). Investigated essential oil was found to exert hepatoprotective effects in the doses of 5 mg/kg and 10 mg/kg by diminishing AST and ALT activities up to 2-fold in serum of rats with carbon tetrachloride - induced acute liver damage. Rosemary essential oil prevented carbon tetrachloride - induced increase of lipid peroxidation in liver homogenates. Furthermore, pre-treatment with studied essential oil during 7 days significantly reversed the activities of antioxidant enzymes catalase, peroxidase, glutathione peroxidase and glutathione reductase in liver homogenates, especially in the dose of 10 mg/kg. Conclusions Our results demonstrate that rosemary essential oil, beside exhibiting free radical scavenging activity determined by DPPH assay, mediates its hepatoprotective effects also through activation of

  12. Selected bibliography: cost and energy savings of conservation and renewable energy technologies

    SciTech Connect

    1980-05-01

    This bibliography is a compilation of reports on the cost and energy savings of conservation and renewable energy applications throughout the United States. It is part of an overall effort to inform utilities of technological developments in conservation and renewable energy technologies and so aid utilities in their planning process to determine the most effective and economic combination of capital investments to meet customer needs. Department of Energy assessments of the applications, current costs and cost goals for the various technologies included in this bibliography are presented. These assessments are based on analyses performed by or for the respective DOE Program Offices. The results are sensitive to a number of variables and assumptions; however, the estimates presented are considered representative. These assessments are presented, followed by some conclusions regarding the potential role of the conservation and renewable energy alternative. The approach used to classify the bibliographic citations and abstracts is outlined.

  13. R and D of energy saving and new energy utilization in Japanese marine engineering

    NASA Astrophysics Data System (ADS)

    Isshiki, N.; Tamaki, H.; Murayama, Y.; Tokuda, S.

    Energy saving measures being studied and implemented in Japan to reduce marine diesel fuel consumption are described. Lower ship speeds, bulb bows, better surface paint, a reaction ladder, low speed diesel engines with long stroke cylinders and superchargers are being tried. Large, low speed, controllable pitch propellers, digital engine control, and waste heat recovery with Rankine cycle generators are other methods under investigation. Blade cooling and reheating are being introduced, and a set of computer controlled maneuverable metal sails undergoing sea tests on a commercial tanker as a fuel saving technique have displayed a 20% fuel savings in tests. A windmill is under design for ship propulsion, involving several vertical airfoils revolving around a vertical axis of rotation. Direct connection to a propeller is being considered, noting that operations to windward would be possible.

  14. Analyzing the Life Cycle Energy Savings of DOE Supported Buildings Technologies

    SciTech Connect

    Cort, Katherine A.; Hostick, Donna J.; Dirks, James A.; Elliott, Douglas B.

    2009-08-31

    This report examines the factors that would potentially help determine an appropriate analytical timeframe for measuring the U.S. Department of Energy's Building Technology (BT) benefits and presents a summary-level analysis of the life cycle savings for BT’s Commercial Buildings Integration (CBI) R&D program. The energy savings for three hypothetical building designs are projected over a 100-year period using Building Energy Analysis and Modeling System (BEAMS) to illustrate the resulting energy and carbon savings associated with the hypothetical aging buildings. The report identifies the tasks required to develop a long-term analytical and modeling framework, and discusses the potential analytical gains and losses by extending an analysis into the “long-term.”

  15. Benchmarking and Energy Saving Tool for Low Carbon Cities (BEST Cities)

    2014-02-01

    BEST-Cities is designed to provide city authorities with strategies they can follow to reduce city-wide carbon dioxide (CO2) and methane (CH4) emissions. The tool quickly assesses local energy use and energy-related CO2 emissions across nine sectors (i.e., industry, public and commercial buildings, residential buildings, transportation, power and heat, street lighting, water & wastewater, solid waste, and urban green space), giving officials a comprehensive perspective on their local carbon performance. Cities can also use the toolmore » to benchmark their energy and emissions performance to other cities inside and outside China, and identify those sectors with the greatest energy saving and emissions reduction potential.« less

  16. Using Revolving Loan Funds to Finance Energy Savings Performance Contracts in State and Local Agency Applications

    SciTech Connect

    Booth, S.; Doris, E.; Knutson, D.; Regenthal, S.

    2011-05-01

    Numerous pre-existing and newly emerging state- and locally-managed revolving loan funds (RLFs) are being used in conjunction with energy savings performance contracts (ESPCs) as an option for financing of energy efficiency projects. This document presents an overview of ESPCs and how they fit within the RLF framework. There are a variety of options available to state and local governments to catalyze the disbursement of available capital from RLFs and increase the number of ESPC projects within their jurisdictions. To demonstrate the implementation of this type of financing program in action, this report concludes with four program case studies of state-sponsored RLFs where ESPCs are an allowed use of funds.

  17. Energy Savings of Low-E Storm Windows and Panels across US Climate Zones

    SciTech Connect

    Culp, Thomas D.; Cort, Katherine A.

    2015-10-01

    This report builds off of previous modeling work related to low-e storm windows used to create a "Database of U.S. Climate-Based Analysis for Low-E Storm Windows." This work updates similar studies using new fuel costs and examining the separate contributions of reduced air leakage and reduced coefficients of overall heat transfer and solar heat gain. In this report we examine the energy savings and cost effectiveness of low-E storm windows in residential homes across a broad range of U.S. climates, excluding the impact from infiltration reductions, which tend to vary using the National Energy Audit Tool (NEAT) and RESFEN model calculations. This report includes a summary of the results, NEAT and RESFEN background, methodology, and input assumptions, and an appendix with detailed results and assumptions by climate zone.

  18. Energy Savings Potential and RD&D Opportunities for Non-Vapor-Compression HVAC Technologies

    SciTech Connect

    none,

    2014-03-01

    While vapor-compression technologies have served heating, ventilation, and air-conditioning (HVAC) needs very effectively, and have been the dominant HVAC technology for close to 100 years, the conventional refrigerants used in vapor-compression equipment contribute to global climate change when released to the atmosphere. This Building Technologies Office report: --Identifies alternatives to vapor-compression technology in residential and commercial HVAC applications --Characterizes these technologies based on their technical energy savings potential, development status, non-energy benefits, and other factors affecting end-user acceptance and their ability to compete with conventional vapor-compression systems --Makes specific research, development, and deployment (RD&D) recommendations to support further development of these technologies, should DOE choose to support non-vapor-compression technology further.

  19. Energy-saving EPON Bandwidth Allocation Algorithm Supporting ONU's Sleep Mode

    NASA Astrophysics Data System (ADS)

    Zhang, Yinfa; Ren, Shuai; Liao, Xiaomin; Fang, Yuanyuan

    2014-09-01

    A new bandwidth allocation algorithm was presented by combining merits of the IPACT algorithm and the cyclic DBA algorithm based on the DBA algorithm for ONU's sleep mode. Simulation results indicate that compared with the normal mode ONU, the ONU's sleep mode can save about 74% of energy. The new algorithm has a smaller average packet delay and queue length in the upstream direction. While in the downstream direction, the average packet delay of the new algorithm is less than polling cycle Tcycle and the average queue length is less than the product of Tcycle and the maximum link rate. The new algorithm achieves a better compromise between energy-saving and ensuring quality of service.

  20. Energy-saving analysis of hydraulic hybrid excavator based on common pressure rail.

    PubMed

    Shen, Wei; Jiang, Jihai; Su, Xiaoyu; Karimi, Hamid Reza

    2013-01-01

    Energy-saving research of excavators is becoming one hot topic due to the increasing energy crisis and environmental deterioration recently. Hydraulic hybrid excavator based on common pressure rail (HHEC) provides an alternative with electric hybrid excavator because it has high power density and environment friendly and easy to modify based on the existing manufacture process. This paper is focused on the fuel consumption of HHEC and the actuator dynamic response to assure that the new system can save energy without sacrificing performance. Firstly, we introduce the basic principle of HHEC; then, the sizing process is presented; furthermore, the modeling period which combined mathematical analysis and experiment identification is listed. Finally, simulation results show that HHEC has a fast dynamic response which can be accepted in engineering and the fuel consumption can be reduced 21% to compare the original LS excavator and even 32% after adopting another smaller engine.

  1. Approaches to 30 Percent Energy Savings at the Community Scale in the Hot-Humid Climate

    SciTech Connect

    Thomas-Rees, S.; Beal, D.; Martin, E.

    2013-03-01

    BA-PIRC has worked with several community-scale builders within the hot humid climate zone to improve performance of production, or community scale, housing. Tommy Williams Homes (Gainesville, FL), Lifestyle Homes (Melbourne, FL), and Habitat for Humanity (various locations, FL) have all been continuous partners of the Building America program and are the subjects of this report to document achievement of the Building America goal of 30% whole house energy savings packages adopted at the community scale. Key aspects of this research include determining how to evolve existing energy efficiency packages to produce replicable target savings, identifying what builders' technical assistance needs are for implementation and working with them to create sustainable quality assurance mechanisms, and documenting the commercial viability through neutral cost analysis and market acceptance. This report documents certain barriers builders overcame and the approaches they implemented in order to accomplish Building America (BA) Program goals that have not already been documented in previous reports.

  2. Energy-saving options for the mitigation of greenhouse gas emissions from the Mongolian energy sector

    SciTech Connect

    Dorjpurev, J.; Purevjal, O.; Erdenechimeg, Ch.

    1996-12-31

    The Energy sector is the largest contributor to GHG emission in Mongolia. The Energy sector emits 54 percent of CO2 and 4 percent of methane. All emissions of other greenhouse gases are accounted from energy related activities. The activities in this sector include coal production, fuel combustion, and biomass combustion at the thermal power stations and in private houses (stoves) for heating purposes. This paper presents some important Demand-side options considered for mitigation of CO2 emissions from energy sector such as Energy Conservation in Industrial Sector and in Buildings. Changes in energy policies and programmes in the Mongolian situation that promote more efficient and sustainable practices are presented in the paper. These energy saving measures will not only help reduce greenhouse gas emissions, but will also promote economic development and alleviate other environmental problems.

  3. California Federal Facilities: Rate-Responsive Building Operation for Deeper Cost and Energy Savings

    SciTech Connect

    2012-05-01

    Dynamic pricing electricity tariffs, now the default for large customers in California (peak demand of 200 kW and higher for PG&E and SCE, and 20 kW and higher for SDG&E), are providing Federal facilities new opportunities to cut their electricity bills and help them meet their energy savings mandates. The U.S. Department of Energy’s (DOE) Federal Energy Management Program (FEMP) has created this fact sheet to help California federal facilities take advantage of these opportunities through “rate-responsive building operation.” Rate-responsive building operation involves designing your load management strategies around your facility’s variable electric rate, using measures that require little or no financial investment.

  4. Energy-Saving Analysis of Hydraulic Hybrid Excavator Based on Common Pressure Rail

    PubMed Central

    Jiang, Jihai; Su, Xiaoyu

    2013-01-01

    Energy-saving research of excavators is becoming one hot topic due to the increasing energy crisis and environmental deterioration recently. Hydraulic hybrid excavator based on common pressure rail (HHEC) provides an alternative with electric hybrid excavator because it has high power density and environment friendly and easy to modify based on the existing manufacture process. This paper is focused on the fuel consumption of HHEC and the actuator dynamic response to assure that the new system can save energy without sacrificing performance. Firstly, we introduce the basic principle of HHEC; then, the sizing process is presented; furthermore, the modeling period which combined mathematical analysis and experiment identification is listed. Finally, simulation results show that HHEC has a fast dynamic response which can be accepted in engineering and the fuel consumption can be reduced 21% to compare the original LS excavator and even 32% after adopting another smaller engine. PMID:24194683

  5. Market analysis, energy savings potential, and future development requirements for Radiance. Final report

    SciTech Connect

    Not Available

    1993-10-01

    The Department of Energy (DOE) Office of Conservation and Renewable Energy (CE), Building Equipment Division has funded the development of a sophisticated computer rendering program called Radiance at Lawrence Berkeley Laboratories (LBL). The project review study included: (1) Surveys of the lighting profession to determine how designers would use an improved, user-friendly Radiance, (2) Elucidation of features, including how Radiance could be used to save energy, which could be incorporated into Radiance to facilitate its more widespread use, (3) Outline of a development plan and determination of what costs the DOE might incur if it were to proceed with the development of an improved version, and (4) Weighing the anticipated development costs against anticipated energy-saving benefits.

  6. Energy efficiency monitoring and economic analysis for energy saving potential in UNITEN

    NASA Astrophysics Data System (ADS)

    Reyasudin Basir Khan, M.; Jidin, Razali; Pasupuleti, Jagadeesh; Yew, Kang Chin; Azwa Shaaya, Sharifah

    2013-06-01

    This paper discusses on energy efficiency survey for typical buildings in Universiti Tenaga Nasional (UNITEN). Undeniably, wastage of energy will cause the increase of operation cost and depletion of fossil fuel resources which contributes to the climate change issue in the world. UNITEN was commenced in the late 1990s and most of the buildings in this university are not equipped with energy management system. Such system is the solution to reduce energy use while maximizing the comfort levels of the occupants. Disregard to the energy management system, the implementation of other energy saving measures is the main objective of this paper. By taking the right measures, the energy wastage in the buildings of this university can be reduced.

  7. Consistent air quality and energy savings provided by heat of compression air dryer

    SciTech Connect

    Brown, F.; Hodel, A.E.

    1986-02-01

    The six-year-old compressed air dryers serving the plant and instrument air needs at Monsanto Company's W.G. Krummrich plant in Sauget, IL were no longer performing at peak efficiency. Dryer reliability had declined. Energy usage of the heat regenerated dryers was substantial. The 60 kw heaters used to regenerate the desiccant were operating 2 1/2 out of 4 hours on a timer controlled continuous cycle. Engineers decided to remove the old, inefficient air compression and drying equipment air compression and drying equipment at the W.G. Krummrich plant and replace it with a state-of-the-art system. The combination of a compressor and dryer package was specified to incorporate heat recovery/energy savings. Monsanto's engineers specified an air system that would operate on demand and use a heat of compression air dryer that was available commercially.

  8. Maximizing Energy Savings Reliability in BC Hydro Industrial Demand-side Management Programs: An Assessment of Performance Incentive Models

    NASA Astrophysics Data System (ADS)

    Gosman, Nathaniel

    For energy utilities faced with expanded jurisdictional energy efficiency requirements and pursuing demand-side management (DSM) incentive programs in the large industrial sector, performance incentive programs can be an effective means to maximize the reliability of planned energy savings. Performance incentive programs balance the objectives of high participation rates with persistent energy savings by: (1) providing financial incentives and resources to minimize constraints to investment in energy efficiency, and (2) requiring that incentive payments be dependent on measured energy savings over time. As BC Hydro increases its DSM initiatives to meet the Clean Energy Act objective to reduce at least 66 per cent of new electricity demand with DSM by 2020, the utility is faced with a higher level of DSM risk, or uncertainties that impact the costeffective acquisition of planned energy savings. For industrial DSM incentive programs, DSM risk can be broken down into project development and project performance risks. Development risk represents the project ramp-up phase and is the risk that planned energy savings do not materialize due to low customer response to program incentives. Performance risk represents the operational phase and is the risk that planned energy savings do not persist over the effective measure life. DSM project development and performance risks are, in turn, a result of industrial economic, technological and organizational conditions, or DSM risk factors. In the BC large industrial sector, and characteristic of large industrial sectors in general, these DSM risk factors include: (1) capital constraints to investment in energy efficiency, (2) commodity price volatility, (3) limited internal staffing resources to deploy towards energy efficiency, (4) variable load, process-based energy saving potential, and (5) a lack of organizational awareness of an operation's energy efficiency over time (energy performance). This research assessed the capacity

  9. Advanced, Integrated Control for Building Operations to Achieve 40% Energy Saving

    SciTech Connect

    Lu, Yan; Song, Zhen; Loftness, Vivian; Ji, Kun; Zheng, Sam; Lasternas, Bertrand; Marion, Flore; Yuebin, Yu

    2012-10-15

    We developed and demonstrated a software based integrated advanced building control platform called Smart Energy Box (SEB), which can coordinate building subsystem controls, integrate variety of energy optimization algorithms and provide proactive and collaborative energy management and control for building operations using weather and occupancy information. The integrated control system is a low cost solution and also features: Scalable component based architecture allows to build a solution for different building control system configurations with needed components; Open Architecture with a central data repository for data exchange among runtime components; Extendible to accommodate variety of communication protocols. Optimal building control for central loads, distributed loads and onsite energy resource; uses web server as a loosely coupled way to engage both building operators and building occupants in collaboration for energy conservation. Based on the open platform of SEB, we have investigated and evaluated a variety of operation and energy saving control strategies on Carnegie Mellon University Intelligent Work place which is equipped with alternative cooling/heating/ventilation/lighting methods, including radiant mullions, radiant cooling/heating ceiling panels, cool waves, dedicated ventilation unit, motorized window and blinds, and external louvers. Based on the validation results of these control strategies, they were integrated in SEB in a collaborative and dynamic way. This advanced control system was programmed and computer tested with a model of the Intelligent Workplace's northern section (IWn). The advanced control program was then installed in the IWn control system; the performance was measured and compared with that of the state of the art control system to verify the overall energy savings great than 40%. In addition advanced human machine interfaces (HMI's) were developed to communicate both with building occupants and

  10. Max Tech Appliance Design: Potential for Maximizing U.S. Energy Savings through Standards

    SciTech Connect

    Garbesi, Karina; Desroches, Louis-Benoit; Bolduc, Christopher; Burch, Gabriel; Hosseinzadeh, Griffin; Saltiel, Seth

    2011-05-06

    This study surveyed the technical potential for efficiency improvements in 150 categories of appliances and equipment representing 33 quads of primary energy use across the US economy in 2010 and (1) documented efficient product designs, (2) identified the most promising cross-cutting strategies, and (3) ranked national energy savings potential by end use. Savings were estimated using a method modeled after US Department of Energy priority-setting reports - simplified versions of the full technical and economic analyses performed for rulemakings. This study demonstrates that large savings are possible by replacing products at the end-of-life with ultra-efficient models that use existing technology. Replacing the 50 top energy-saving end-uses (constituting 30 quads of primary energy consumption in 2010) with today's best-on-market equivalents would save {approx}200 quads of US primary energy over 30 years (25% of consumption anticipated there from). For the 29 products for maximum feasible savings potential could be estimated, the savings were twice as high. These results demonstrate that pushing ultra-efficient products to market could significantly escalate carbon emission reductions and is a viable strategy for sustaining large emissions reductions through standards. The results of this analysis were used by DOE for new coverage prioritization, to identify key opportunities for product prototyping and market development, and will leverage future standards rulemakings by identifying the full scope of maximum feasible technology options. High leverage products include advances lighting systems, HVAC, and televisions. High leverage technologies include electronic lighting, heat pumps, variable speed motors, and a host of controls-related technologies.

  11. Verifying energy savings with minimal metered data: The Hunter heat pump analysis

    SciTech Connect

    Parker, S.A.

    1995-03-01

    In November 1992, Hunter Army Air Field (AAF) completed the installation of 489 air-source heat pumps -- a new heat pump and air-handling unit for each residence. The air-source heat pumps replaced older, less efficient, air-conditioning systems, fuel oil-fired furnaces, and fan coil units. Hunter AAF originally contacted to upgrade the old family housing heating, ventilating, and air-conditioning (HVAC) systems with high efficiency air-conditioning systems and natural gas furnaces, but an alternative proposal and following energy studies indicated that heat pumps were a more life-cycle cost-effective alternative. Six months after the heat pumps were installed, Hunter`s energy bills appeared to be increasing, not decreasing as expected. In early 1994, Pacific Northwest Laboratory` (PNL) began an analysis to determine if there were any energy savings resulting from the heat pump installation as predicted by previous energy studies. The problem is that the HVAC systems are not specifically submetered to support verifying the resulting energy savings and, as is the case with most federal facilities, even the homes are not individually metered. Savings verification needed to be accomplished with die existing and available metered data. This data consisted primarily of monthly electric submeter readings from the two housing subdivision meters, historical fuel oil delivery records for family housing, and monthly base-wide electric bills. The objective of the study is to verify the change in energy consumption in family housing and, to the extent possible, identify how much of the change in consumption is attributable to the new HVAC system and how much is probably attributable to other factors, such as the weather.

  12. Color tunable low cost transparent heat reflector using copper and titanium oxide for energy saving application.

    PubMed

    Dalapati, Goutam Kumar; Masudy-Panah, Saeid; Chua, Sing Teng; Sharma, Mohit; Wong, Ten It; Tan, Hui Ru; Chi, Dongzhi

    2016-01-01

    Multilayer coating structure comprising a copper (Cu) layer sandwiched between titanium dioxide (TiO2) were demonstrated as a transparent heat reflecting (THR) coating on glass for energy-saving window application. The main highlight is the utilization of Cu, a low-cost material, in-lieu of silver which is widely used in current commercial heat reflecting coating on glass. Color tunable transparent heat reflecting coating was realized through the design of multilayer structure and process optimization. The impact of thermal treatment on the overall performance of sputter deposited TiO2/Cu/TiO2 multilayer thin film on glass substrate is investigated in detail. Significant enhancement of transmittance in the visible range and reflectance in the infra-red (IR) region has been observed after thermal treatment of TiO2/Cu/TiO2 multilayer thin film at 500 °C due to the improvement of crystal quality of TiO2. Highest visible transmittance of 90% and IR reflectance of 85% at a wavelength of 1200 nm are demonstrated for the TiO2/Cu/TiO2 multilayer thin film after annealing at 500 °C. Performance of TiO2/Cu/TiO2 heat reflector coating decreases after thermal treatment at 600 °C. The wear performance of the TiO2/Cu/TiO2 multilayer structure has been evaluated through scratch hardness test. The present work shows promising characteristics of Cu-based THR coating for energy-saving building industry. PMID:26846687

  13. Color tunable low cost transparent heat reflector using copper and titanium oxide for energy saving application

    PubMed Central

    Dalapati, Goutam Kumar; Masudy-Panah, Saeid; Chua, Sing Teng; Sharma, Mohit; Wong, Ten It; Tan, Hui Ru; Chi, Dongzhi

    2016-01-01

    Multilayer coating structure comprising a copper (Cu) layer sandwiched between titanium dioxide (TiO2) were demonstrated as a transparent heat reflecting (THR) coating on glass for energy-saving window application. The main highlight is the utilization of Cu, a low-cost material, in-lieu of silver which is widely used in current commercial heat reflecting coating on glass. Color tunable transparent heat reflecting coating was realized through the design of multilayer structure and process optimization. The impact of thermal treatment on the overall performance of sputter deposited TiO2/Cu/TiO2 multilayer thin film on glass substrate is investigated in detail. Significant enhancement of transmittance in the visible range and reflectance in the infra-red (IR) region has been observed after thermal treatment of TiO2/Cu/TiO2 multilayer thin film at 500 °C due to the improvement of crystal quality of TiO2. Highest visible transmittance of 90% and IR reflectance of 85% at a wavelength of 1200 nm are demonstrated for the TiO2/Cu/TiO2 multilayer thin film after annealing at 500 °C. Performance of TiO2/Cu/TiO2 heat reflector coating decreases after thermal treatment at 600 °C. The wear performance of the TiO2/Cu/TiO2 multilayer structure has been evaluated through scratch hardness test. The present work shows promising characteristics of Cu-based THR coating for energy-saving building industry. PMID:26846687

  14. Assessment of energy-saving strategies and operational costs in full-scale membrane bioreactors.

    PubMed

    Gabarrón, S; Ferrero, G; Dalmau, M; Comas, J; Rodriguez-Roda, I

    2014-02-15

    The energy-saving strategies and operational costs of stand-alone, hybrid, and dual stream full-scale membrane bioreactors (MBRs) with capacities ranging from 1100 to 35,000 m(3) day(-1) have been assessed for seven municipal facilities located in Northeast Spain. Although hydraulic load was found to be the main determinant factor for the energy consumption rates, several optimisation strategies have shown to be effective in terms of energy reduction as well as fouling phenomenon minimization or preservation. Specifically, modifications of the biological process (installation of control systems for biological aeration) and of the filtration process (reduction of the flux or mixed liquor suspended solids concentration and installation of control systems for membrane air scouring) were applied in two stand-alone MBRs. After implementing these strategies, the yearly specific energy demand (SED) in flat-sheet (FS) and hollow-fibre (HF) stand-alone MBRs was reduced from 1.12 to 0.71 and from 1.54 to 1.12 kW h(-1) m(-3), respectively, regardless of their similar yearly averaged hydraulic loads. The strategies applied in the hybrid MBR, namely, buffering the influent flow and optimisation of both biological aeration and membrane air-scouring, reduced the SED values by 14%. These results illustrate that it is possible to apply energy-saving strategies to significantly reduce MBR operational costs, highlighting the need to optimise MBR facilities to reconsider them as an energy-competitive option.

  15. Thermodynamics of greenhouse systems for the northern latitudes: analysis, evaluation and prospects for primary energy saving.

    PubMed

    Bronchart, Filip; De Paepe, Michel; Dewulf, Jo; Schrevens, Eddie; Demeyer, Peter

    2013-04-15

    In Flanders and the Netherlands greenhouse production systems produce economically important quantities of vegetables, fruit and ornamentals. Indoor environmental control has resulted in high primary energy use. Until now, the research on saving primary energy in greenhouse systems has been mainly based on analysis of energy balances. However, according to the thermodynamic theory, an analysis based on the concept of exergy (free energy) and energy can result in new insights and primary energy savings. Therefore in this paper, we analyse the exergy and energy of various processes, inputs and outputs of a general greenhouse system. Also a total system analysis is then performed by linking the exergy analysis with a dynamic greenhouse climate growth simulation model. The exergy analysis indicates that some processes ("Sources") lie at the origin of several other processes, both destroying the exergy of primary energy inputs. The exergy destruction of these Sources is caused primarily by heat and vapour loss. Their impact can be compensated by exergy input from heating, solar radiation, or both. If the exergy destruction of these Sources is reduced, the necessary compensation can also be reduced. This can be accomplished through insulating the greenhouse and making the building more airtight. Other necessary Sources, namely transpiration and loss of CO2, have a low exergy destruction compared to the other Sources. They are therefore the best candidate for "pump" technologies ("vapour heat pump" and "CO2 pump") designed to have a low primary energy use. The combination of these proposed technologies results in an exergy efficient greenhouse with the highest primary energy savings. It can be concluded that exergy analyses add additional information compared to only energy analyses and it supports the development of primary energy efficient greenhouse systems.

  16. Assessment of energy-saving strategies and operational costs in full-scale membrane bioreactors.

    PubMed

    Gabarrón, S; Ferrero, G; Dalmau, M; Comas, J; Rodriguez-Roda, I

    2014-02-15

    The energy-saving strategies and operational costs of stand-alone, hybrid, and dual stream full-scale membrane bioreactors (MBRs) with capacities ranging from 1100 to 35,000 m(3) day(-1) have been assessed for seven municipal facilities located in Northeast Spain. Although hydraulic load was found to be the main determinant factor for the energy consumption rates, several optimisation strategies have shown to be effective in terms of energy reduction as well as fouling phenomenon minimization or preservation. Specifically, modifications of the biological process (installation of control systems for biological aeration) and of the filtration process (reduction of the flux or mixed liquor suspended solids concentration and installation of control systems for membrane air scouring) were applied in two stand-alone MBRs. After implementing these strategies, the yearly specific energy demand (SED) in flat-sheet (FS) and hollow-fibre (HF) stand-alone MBRs was reduced from 1.12 to 0.71 and from 1.54 to 1.12 kW h(-1) m(-3), respectively, regardless of their similar yearly averaged hydraulic loads. The strategies applied in the hybrid MBR, namely, buffering the influent flow and optimisation of both biological aeration and membrane air-scouring, reduced the SED values by 14%. These results illustrate that it is possible to apply energy-saving strategies to significantly reduce MBR operational costs, highlighting the need to optimise MBR facilities to reconsider them as an energy-competitive option. PMID:24463730

  17. Extension to phase 2 energy savings evaluation of the commercial direct investment program

    SciTech Connect

    Trumble, D.; MacDonald, M.

    1994-08-01

    The results of an analysis of the commercial direct investment program of the Commonwealth Energy System (COM/Electric) is presented. The analysis extends results obtained in a previous impact evaluation of energy savings. The analysis includes over 1,000 buildings that participated in the program. The previous evaluation showed net program savings, using simple, aggregate annual measures of energy use and a control group adjustment, of about 8.7 GWh/yr (14% of pre-retrofit energy use) for an investment of $4.4 million, which leads to an investment cost ratio (investment divided by first year savings) of about $0.50/kWh. Inherent difficulties with simple, aggregate calculations, with the PRInceton Scorekeeping Method (PRISM), and with econometric approaches for these types of evaluations are discussed and an extension to PRISM proposed as an alternative. Energy savings for this program are estimated using both simple, aggregate data and the extended PRISM approach (two-stage regression modeling). The aggregate data provide important insight about program performance, while the two-stage regression modeling helps reduce variability in results. Overall, the impact evaluation results indicate that the net program investment cost ratio, the ratio of total costs to net electricity savings, is close to $0.60/kWh when weather and cost factors are included. Economic factors were included in savings estimate calculations, but the results indicated either data endogeneity or high variance problems, so economic effects cannot be inferred as being estimable for the data set on this small C/I program with the methods used here. Program performance is at the margin of acceptable performance, and because of this marginality, improvements in program execution are desirable. Program performance at the margin could be improved significantly by controlling for potentially poor retrofit choices.

  18. Color tunable low cost transparent heat reflector using copper and titanium oxide for energy saving application

    NASA Astrophysics Data System (ADS)

    Dalapati, Goutam Kumar; Masudy-Panah, Saeid; Chua, Sing Teng; Sharma, Mohit; Wong, Ten It; Tan, Hui Ru; Chi, Dongzhi

    2016-02-01

    Multilayer coating structure comprising a copper (Cu) layer sandwiched between titanium dioxide (TiO2) were demonstrated as a transparent heat reflecting (THR) coating on glass for energy-saving window application. The main highlight is the utilization of Cu, a low-cost material, in-lieu of silver which is widely used in current commercial heat reflecting coating on glass. Color tunable transparent heat reflecting coating was realized through the design of multilayer structure and process optimization. The impact of thermal treatment on the overall performance of sputter deposited TiO2/Cu/TiO2 multilayer thin film on glass substrate is investigated in detail. Significant enhancement of transmittance in the visible range and reflectance in the infra-red (IR) region has been observed after thermal treatment of TiO2/Cu/TiO2 multilayer thin film at 500 °C due to the improvement of crystal quality of TiO2. Highest visible transmittance of 90% and IR reflectance of 85% at a wavelength of 1200 nm are demonstrated for the TiO2/Cu/TiO2 multilayer thin film after annealing at 500 °C. Performance of TiO2/Cu/TiO2 heat reflector coating decreases after thermal treatment at 600 °C. The wear performance of the TiO2/Cu/TiO2 multilayer structure has been evaluated through scratch hardness test. The present work shows promising characteristics of Cu-based THR coating for energy-saving building industry.

  19. Impact evaluation of an energy savings plan project at Lamb-Weston, Inc

    SciTech Connect

    Spanner, G.E.; Wilfert, G.L.

    1990-06-01

    This impact evaluation of an energy conservation measure (ECM) that was recently installed at Lamb-Weston, Inc. (Lamb-Weston) was conducted for the Bonneville Power Administration (Bonneville) as part of an evaluation of its Energy $avings Plan (E$P) Program. The Program awards cash incentives to firms that install energy conservation measures in their industrial processes. The objective of this impact evaluation was to assess how much electrical energy is being saved at Lamb-Weston as a result of the E$P and to determine how much the savings cost Bonneville and the region. The impact of the ECM was evaluated with a combination of engineering analysis, financial analysis, interviews, submittal reviews (Lamb-Weston's Completion Report, Proposal, and Abstract), and process evaluation reviews. The ECM itself consists of a heat recovery heat exchanger added to the hot drain of a potato blancher to reclaim heat that would otherwise be discarded at Lamb-Weston's Plant 1 in Quincy, Washington. At this facility, Lamb-Weston makes frozen French fried potatoes for institutional and consumer markets. Energy savings resulting from this ECM are expected to be 4,037,101 kWh per year. The ECM cost $67, 020 to install and Lamb-Weston received an incentive from Bonneville of $40, 212. The levelized cost of these energy savings to Bonneville will be 0.83 mills/kWh over the ECM's expected 15-year life, and the levelized cost to the region will be 1.50 mills/kWh.

  20. Thermodynamics of greenhouse systems for the northern latitudes: analysis, evaluation and prospects for primary energy saving.

    PubMed

    Bronchart, Filip; De Paepe, Michel; Dewulf, Jo; Schrevens, Eddie; Demeyer, Peter

    2013-04-15

    In Flanders and the Netherlands greenhouse production systems produce economically important quantities of vegetables, fruit and ornamentals. Indoor environmental control has resulted in high primary energy use. Until now, the research on saving primary energy in greenhouse systems has been mainly based on analysis of energy balances. However, according to the thermodynamic theory, an analysis based on the concept of exergy (free energy) and energy can result in new insights and primary energy savings. Therefore in this paper, we analyse the exergy and energy of various processes, inputs and outputs of a general greenhouse system. Also a total system analysis is then performed by linking the exergy analysis with a dynamic greenhouse climate growth simulation model. The exergy analysis indicates that some processes ("Sources") lie at the origin of several other processes, both destroying the exergy of primary energy inputs. The exergy destruction of these Sources is caused primarily by heat and vapour loss. Their impact can be compensated by exergy input from heating, solar radiation, or both. If the exergy destruction of these Sources is reduced, the necessary compensation can also be reduced. This can be accomplished through insulating the greenhouse and making the building more airtight. Other necessary Sources, namely transpiration and loss of CO2, have a low exergy destruction compared to the other Sources. They are therefore the best candidate for "pump" technologies ("vapour heat pump" and "CO2 pump") designed to have a low primary energy use. The combination of these proposed technologies results in an exergy efficient greenhouse with the highest primary energy savings. It can be concluded that exergy analyses add additional information compared to only energy analyses and it supports the development of primary energy efficient greenhouse systems. PMID:23474336

  1. The Effect of Hands-on '"Energy-Saving House" Learning Activities on Elementary School Students' Knowledge, Attitudes, and Behavior Regarding Energy Saving and Carbon-Emissions Reduction

    ERIC Educational Resources Information Center

    Lee, Lung-Sheng; Lin, Kuen-Yi; Guu, Yunn-Horng; Chang, Liang-Te; Lai, Chih-Chien

    2013-01-01

    Energy saving and carbon-emissions reduction (ESCER) are widely regarded as important issues for progress towards ensuring sustainable forms of economic development. This Taiwanese study focuses on the effects of a series of educational activities about ESCER on students' knowledge, attitudes and behavior. Sixty fifth-grade students from two…

  2. Hepatoprotective and antioxidant activity of two iridoids from Mussaenda 'dona aurora'.

    PubMed

    Vidyalakshmi, Kandulva Sethuraman; Nagarajan, Sulochana; Vasanthi, Hannah Rachel; Venkappaya; Rajamanickam, Victor

    2009-01-01

    Mussaenda 'dona aurora' (sepals) has been investigated for its hepatoprotective and antioxidant activities. The highest activity was observed in the ethyl acetate fraction. The separation of the ethyl acetate fraction gave two iridoids, sanshiside-D and lamalbide. Sanshiside-D exhibited a hepatoprotective activity greater than silimarin as was evidenced by significant reduction of ALT and AST in the serum enzyme levels.

  3. Occupant-in-Place Energy Efficiency Retrofit in a Group Home for 30% Energy Savings in Climate Zone 4

    SciTech Connect

    Moore, Mike

    2013-08-01

    Energy efficiency retrofits (EERs) face many challenges on the path to scalability. Limited budgets, cost effectiveness, risk factors, and accessibility impact the type and the extent of measures that can be implemented feasibly to achieve energy savings goals. Group home retrofits can face additional challenges than those in single family homes – such as reduced access (occupant-in-place restrictions) and lack of incentives for occupant behavioral change. This project studies the specification, implementation, and energy savings from an EER in a group home, with an energy savings goal of 30%. This short term test report chronicles the retrofit measures specified, their projected cost effectiveness using building energy simulations, and the short term test results that were used to characterize pre-retrofit and post-retrofit conditions. Additionally, the final report for the project will include analysis of pre- and post-retrofit performance data on whole building energy use, and an assessment of the energy impact of occupant interface with the building (i.e., window operation). Ultimately, the study’s results will be used to identify cost-effective EER measures that can be implemented in group homes, given constraints that are characteristic of these buildings. Results will also point towards opportunities for future energy savings.

  4. Occupant-in-Place Energy Efficiency Retrofit in a Group Home for 30% Energy Savings in Climate Zone 4

    SciTech Connect

    Moore, M.

    2013-08-01

    Energy efficiency retrofits (EERs) face many challenges on the path to scalability. Limited budgets, cost effectiveness, risk factors, and accessibility impact the type and the extent of measures that can be implemented feasibly to achieve energy savings goals. Group home retrofits can face additional challenges than those in single family homes - such as reduced access (occupant-in-place restrictions) and lack of incentives for occupant behavioral change. This project studies the specification, implementation, and energy savings from an EER in a group home, with an energy savings goal of 30%. This short term test report chronicles the retrofit measures specified, their projected cost-effectiveness using building energy simulations, and the short term test results that were used to characterize pre-retrofit and post-retrofit conditions. Additionally, the final report for the project will include analysis of pre- and post-retrofit performance data on whole building energy use, and an assessment of the energy impact of occupant interface with the building (i.e., window operation). Ultimately, the study's results will be used to identify cost effective EER measures that can be implemented in group homes, given constraints that are characteristic of these buildings. Results will also point towards opportunities for future energy savings.

  5. In the Bank...Or Up the Chimney? A Dollars and Cents Guide to Energy-Saving Home Improvements.

    ERIC Educational Resources Information Center

    Ackerman, Allan D.; And Others

    This book is designed to answer energy conservation questions about the home. It explains what energy conservation procedures are most efficient and under what conditions. Means for estimating the financial cost of these energy-saving home improvements are included. The book is divided into four parts: (1) A quick look at your home; (2) A closer…

  6. Existing Whole-House Solutions Case Study: Evaluating Energy Savings in All-Electric Public Housing in the Pacific Northwest

    SciTech Connect

    2014-03-01

    This project analyzes the cost effectiveness of energy-saving measures installed by a large public housing authority in Salishan, and evaluates those solutions to improve efficiency of affordable housing for new and existing homes. Research focuses on the modeled and measured energy usage of the first six phases of construction, and compares the energy usage of those phases to phase 7.

  7. Hands-on solutions to improve your profits and productivity: Energy-saving tips for small businesses

    SciTech Connect

    1996-03-01

    This booklet leads small business owners to examine the energy consumption of their business and implement significant energy saving modifications and practices. The topics of the booklet include evaluating energy use and suggestions for energy conservation in lighting systems, building envelope and materials, space conditioning, equipment and machines, motors, and vehicles.

  8. Energy Saving Melting and Revert Reduction Technology (Energy SMARRT): Manufacturing Advanced Engineered Components Using Lost Foam Casting Technology

    SciTech Connect

    Littleton, Harry; Griffin, John

    2011-07-31

    This project was a subtask of Energy Saving Melting and Revert Reduction Technology (Energy SMARRT) Program. Through this project, technologies, such as computer modeling, pattern quality control, casting quality control and marketing tools, were developed to advance the Lost Foam Casting process application and provide greater energy savings. These technologies have improved (1) production efficiency, (2) mechanical properties, and (3) marketability of lost foam castings. All three reduce energy consumption in the metals casting industry. This report summarizes the work done on all tasks in the period of January 1, 2004 through June 30, 2011. Current (2011) annual energy saving estimates based on commercial introduction in 2011 and a market penetration of 97% by 2020 is 5.02 trillion BTU's/year and 6.46 trillion BTU's/year with 100% market penetration by 2023. Along with these energy savings, reduction of scrap and improvement in casting yield will result in a reduction of the environmental emissions associated with the melting and pouring of the metal which will be saved as a result of this technology. The average annual estimate of CO2 reduction per year through 2020 is 0.03 Million Metric Tons of Carbon Equivalent (MM TCE).

  9. Heat recovery from waste water by energy-saving heat pump systems in connection with water treatment plants

    NASA Astrophysics Data System (ADS)

    Wiedmann, U.; Flohrschuetz, R.

    1980-04-01

    The advantages of waste water recovery as an energy source were investigated. It was found that heat pump systems reach the highest performance coefficients and their primary energy ratios are competitive with conventional heating systems. It is concluded that the utilization of waste water treatment plants by large heat pump systems provides a considerable annual energy saving of light oil.

  10. Existing Whole-House Solutions Case Study: Group Home Energy Efficiency Retrofit for 30% Energy Savings, Washington, D.C.

    SciTech Connect

    2013-11-01

    Energy efficiency retrofits (EERs) face many challenges on the path to scalability. Limited budgets, cost effectiveness, risk factors, and accessibility impact the type and the extent of measures that can be implemented feasibly to achieve energy savings goals. Group home retrofits can face additional challenges than those in single family homes – such as reduced access (occupant-in-place restrictions) and lack of incentives for occupant behavioral change. This project studies the specification, implementation, and energy savings from an EER in a group home, with an energy savings goal of 30%. This short term test report chronicles the retrofit measures specified, their projected cost-effectiveness using building energy simulations, and the short term test results that were used to characterize pre-retrofit and post-retrofit conditions. Additionally, the final report for the project will include analysis of pre- and post-retrofit performance data on whole building energy use, and an assessment of the energy impact of occupant interface with the building (i.e., window operation). Ultimately, the study’s results will be used to identify cost effective EER measures that can be implemented in group homes, given constraints that are characteristic of these buildings. Results will also point towards opportunities for future energy savings.

  11. Hepatoprotective activity of Calotropis gigantea flowers against carbon-tetrachloride-induced liver damage in mice.

    PubMed

    Ingawale, Deepa Krushna; Mandlik, Satish Karbhari; Kshirsagar, Ajay Digambar

    2013-07-23

    Ethanol extract of Calotropis gigantea flowers (CGFE) was evaluated for its antioxidant and hepatoprotective activity to validate its use in traditional therapeutic indications. This CGFE exhibited significant antioxidant activity (at 20, 40, 60, 80 and 100 µg/ml in vitro) as evidenced by its hydroxyl, nitric oxide and hydrogen peroxide anion radical scavenging activities. This in vitro antioxidant activity was reinforced by a significant hepatoprotection (at 250 and 500 mg/kg dose) by decreasing the activity of serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase. The hepatoprotective activity of the CGFE was comparable with standard drug silymarin (100 mg/kg, p.o.).The results obtained from present study indicate the presence of natural antioxidants and hepatoprotective constituents. Hence, the above finding confirms in vitro antioxidant and hepatoprotective potential of CGFE in mice.

  12. Hepatoprotective and anti-inflammatory activities of Plantago major L

    PubMed Central

    Türel, Idris; Özbek, Hanefi; Erten, Remzi; Öner, Ahmet Cihat; Cengiz, Nureddin; Yilmaz, Orhan

    2009-01-01

    Objective: The aim of this study was to investigate anti-inflammatory and hepatoprotective activities of Plantago major L. (PM). Materials and Methods: Anti-inflammatory activity: Control and reference groups were administered isotonic saline solution (ISS) and indomethacin, respectively. Plantago major groups were injected PM in doses of 5 mg/kg (PM-I), 10 mg/kg (PM-II), 20 mg/kg (PM-III) and 25 mg/kg (PM-IV). Before and three hours after the injections, the volume of right hind-paw of rats was measured using a plethysmometer. Hepatoprotective Activity: The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Control, CCl4 and reference groups received isotonic saline solution, CCl4 and silibinin, respectively. Plantago major groups received CCl4 (0.8 ml/kg) and PM in doses of 10, 20 and 25 mg/kg, respectively for seven days. Blood samples and liver were collected on the 8th day after the animals were killed. Results: Plantago major had an anti-inflammatory effect matching to that of control group at doses of 20 and 25 mg/kg. It was found that reduction in the inflammation was 90.01% with indomethacin, 3.10% with PM-I, 41.56% with PM-II, 45.87% with PM-III and 49.76% with PM-IV. Median effective dose (ED50) value of PM was found to be 7.507 mg/kg. Plantago major (25 mg/kg) significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels when compared to the CCl4 group. The histopathological findings showed a significant difference between the PM (25 mg/kg) and CCl4 groups. Conclusion: The results showed that PM had a considerable anti-inflammatory and hepatoprotective activities. PMID:20442819

  13. Neuropharmacological safety evaluation of jigrine: A polyherbal hepatoprotective formulation

    PubMed Central

    Najmi, A. K.; Pillai, K. K.; Pal, S. N.; Akhtar, M.; Mujeeb, M.; Aftab, A.

    2010-01-01

    Objective Jigrine is a herbal hepatoprotective formulation containing aqueous extracts of 14 medicinal plants. Present study was designed to evaluate per se neuropharmacological effects of jigrine in mice. Materials and Methods Jigrine was evaluated in a number of pharmacological test paradigms, viz. open field arena, actophotometer, hole board, rotarod, traction test, grip strength test, spontaneous alternation behavior, passive avoidance task, and phenobarbital sleeping time. Results and Conclusions Jigrine pretreatment (1 and 2 ml/kg, p.o.) did not produce any significant effect as compared to normal saline treated animals and was found to be free from any acute undesirable central effects at these two dose levels. PMID:21180466

  14. Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries

    SciTech Connect

    Yoshikawa, Yukitaka; Miyashita, Taishi; Higuchi, Satonori; Tsuneyama, Koichi; Endo, Shinya; Tsukui, Tohru; Toyoda, Yasuyuki; Fukami, Tatsuki; Nakajima, Miki; Yokoi, Tsuyoshi

    2012-10-01

    Although estrogen receptor (ER)α agonists, such as estradiol and ethinylestradiol (EE2), cause cholestasis in mice, they also reduce the degree of liver injury caused by hepatotoxicants as well as ischemia–reperfusion. The functional mechanisms of ERα have yet to be elucidated in drug-induced or chemical-induced liver injury. The present study investigated the effects of an ERα agonist, selective ER modulators (SERMs) and an ER antagonist on drug-induced and chemical-induced liver injuries caused by acetaminophen, bromobenzene, diclofenac, and thioacetamide (TA). We observed hepatoprotective effects of EE2, tamoxifen (TAM) and raloxifene pretreatment in female mice that were exposed to a variety of hepatotoxic compounds. In contrast, the ER antagonist did not show any hepatoprotective effects. DNA microarray analyses suggested that monocyte to macrophage differentiation-associated 2 (Mmd2) protein, which has an unknown function, is commonly increased by TAM and RAL pretreatment, but not by pretreatment with the ER antagonist. In ERα-knockout mice, the hepatoprotective effects of TAM and the increased expression of Mmd2 mRNA were not observed in TA-induced liver injury. To investigate the function of Mmd2, the expression level of Mmd2 mRNA was significantly knocked down to approximately 30% in mice by injection of siRNA for Mmd2 (siMmd2). Mmd2 knockdown resulted in a reduction of the protective effects of TAM on TA-induced liver injury in mice. This is the first report of the involvement of ERα in drug-induced or chemical-induced liver injury. Upregulation of Mmd2 protein in the liver was suggested as the mechanism of the hepatoprotective effects of EE2 and SERMs. -- Highlights: ► Liver injury induced by drugs or chemicals was investigated in mice. ► Liver injury was suppressed by pretreatment with tamoxifen in female mice. ► Mmd2, whose function was unknown, could be a candidate gene for liver protection. ► Tamoxifen up-regulated Mmd2 mRNA expression

  15. TASK 2.5.4 DEVELOPMENT OF AN ENERGY SAVINGS CALCULATOR

    SciTech Connect

    Miller, William A; New, Joshua Ryan; Desjarlais, Andre Omer; Huang, Joe; Erdem, Ender; Ronnen, Levinson

    2010-03-01

    California s major energy utilities and the California Energy Commission (CEC) are seeking to allocate capital that yields the greatest return on investment for energy infrastructure that meets any part of the need for reliable supplies of energy. The utilities are keenly interested in knowing the amount of electrical energy savings that would occur if cool roof color materials are adopted in the building market. To meet this need the Oak Ridge National Laboratory and the Lawrence Berkeley National Laboratory (LBNL) have been collaborating on a Public Interest Energy Research (PIER) project to develop an industry-consensus energy-savings calculator. The task was coordinated with an ongoing effort supported by the DOE to develop one calculator to achieve both the DOE and the EPA objectives for deployment of cool roof products. Recent emphasis on domestic building energy use has made the work a top priority by the Department of Energy s (DOE) Building Technologies Program. The Roof Savings Calculator (RSC) tool is designed to help building owners, manufacturers, distributors, contractors and practitioners easily run complex simulations. The latest web technologies and usability design were employed to provide an easy input interface to an annual simulation of hour-by-hour, whole-building performance using the world-class simulation tools DOE-2.1E and AtticSim. Building defaults were assigned based on the best available statistical evidence and can provide energy and cost savings after the user selects nothing more than the building location. A key goal for the tool is to promote the energy benefits of cool color tile, metal and asphalt shingle roof products and other energy saving systems. The RSC tool focuses on applications for the roof and attic; however, the code conducts a whole building simulation that puts the energy and heat flows of the roof and attic into the perspective of the whole house. An annual simulation runs in about 30 sec. In addition to cool

  16. A new Energy Saving method of manufacturing ceramic products from waste glass

    SciTech Connect

    Haun Labs

    2002-07-05

    This final report summarizes the activities of the DOE Inventions and Innovations sponsored project, ''A New Energy Saving Method of Manufacturing Ceramic Products from Waste Glass.'' The project involved an innovative method of lowering energy costs of manufacturing ceramic products by substituting traditional raw materials with waste glass. The processing method is based on sintering of glass powder at {approx}750 C to produce products which traditionally require firing temperatures of >1200 C, or glass-melting temperatures >1500 C. The key to the new method is the elimination of previous processing problems, which have greatly limited the use of recycled glass as a ceramic raw material. The technology is aligned with the DOE-OIT Glass Industry Vision and Roadmap, and offers significant energy savings and environmental benefits compared to current technologies. A U.S. patent (No. 6,340,650) covering the technology was issued on January 22, 2002. An international PCT Patent Application is pending with designations made for all PCT regions and countries. The goal of the project was to provide the basis for the design and construction of an energy-efficient manufacturing plant that can convert large volumes of waste glass into high-quality ceramic tile. The main objectives of the project were to complete process development and optimization; construct and test prototype samples; and conduct market analysis and commercialization planning. Two types of ceramic tile products were targeted by the project. The first type was developed during the first year (Phase I) to have a glazed-like finish for applications where slip resistance is not critical, such as wall tile. The processing method optimized in Phase I produces a glossy surface with a translucent appearance, without the extra glazing steps required in traditional tile manufacturing. The second type of product was developed during the second year (Phase II). This product was designed to have an unglazed appearance

  17. Synthesis and hepatoprotective properties of Acanthus ilicifolius alkaloid A and its derivatives.

    PubMed

    Liu, Lin; Fan, Hui; Qi, Ping; Mei, Yan; Zhou, Lijuan; Cai, Liping; Lin, Xing; Lin, Jun

    2013-09-01

    Acanthus ilicifolius alkaloid A (4-hydroxy-2(3H)benzoxazolone, HBOA) is a naturally occurring compound that has been separated from Acanthus ilicifolius. Previous studies have reported the beneficial effects of HBOA on HSC-T6 cells. This study was undertaken in order to synthesize HBOA and two of its derivatives, specifically, 4-acetoxy-2(3H)-benzoxazolone (AcO-BOA) and 3-acetyl-4-acetoxy-2-benzoxazolone (TC-3), and to investigate the hepatoprotective potentials of these three compounds on CCl4-induced liver injury in mice. HBOA was prepared from 2-nitroresorcinol by a 'one pot' reduction and subsequent cyclization with urea. The acyl derivatives, AcO-BOA and TC-3, were prepared from HBOA using a substitution reaction. The compounds were synthesized with good yields (63.08-68.22%). An acute liver injury model was established by administering CCl4 intraperitoneally to Kunming mice. The mice were then intragastrically administered bifendate (150 mg/kg) or the synthesized compounds at three different doses (200, 100 and 50 mg/kg). The treatment with CCl4 was observed to increase the levels of aminotransferase (ALT), aspartate aminotransferase (AST), lactic dehydrogenase (LDH) and malondialdehyde (MDA) and decrease the levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione peroxidase (Gpx) in the liver tissues of the mice. Furthermore, treatment with CCl4 elevated the expression level of the proinflammatory mediator TNF-α. However, HBOA and its derivatives attenuated the changes induced by CCl4. Furthermore, CCl4-induced histopathological changes were reduced by treatment with these compounds. These results suggest that HBOA and its acyl derivatives are able to significantly alleviate the hepatotoxicity induced by CCl4 in mice.

  18. Evaluation of Antioxidant and Hepatoprotective Activities of Moringa oleifera Lam. Leaves in Carbon Tetrachloride-Intoxicated Rats

    PubMed Central

    Singh, Dharmendra; Arya, Priya Vrat; Aggarwal, Ved Prakash; Gupta, Radhey Shyam

    2014-01-01

    The antioxidant and hepatoprotective activities of the extract of Moringa oleifera leaves were investigated against CCl4-induced hepatotoxicity in rats. Hepatotoxic rats were treated with ethanol extract of Moringa oleifera for a period of 60 days at the following three dose levels; 100, 200 and 400 mg/kg body weight/day, orally. The activities were studied by assaying the serum marker enzymes like SGOT, SGPT, GGT, LDH, ALP, ACP, as well as total bilirubin, total protein and albumin in serum concomitantly with the activities of LPO, SOD, CAT, GSH, GR and GPx in liver. The activities of all parameters registered a significant (p ≤ 0.001) alteration in CCl4 treated rats, which were significantly recovered towards an almost normal level in rats co-administered with M. oleifera extract in a dose-dependent manner. All the biochemical investigations were confirmed by the histopathological observations and compared with the standard drug. silymarin. Results suggest that the antioxidant and hepatoprotective activities of M. oleifera leaves are possibly related to the free radical scavenging activity which might be due to the presence of total phenolics and flavonoids in the extract and/or the purified compounds β-sitosterol, quercetin and kaempferol, which were isolated from the ethanol extract of M. oleifera leaves. PMID:26785072

  19. Duration-dependent hepatoprotective effects of propolis extract against carbon tetrachloride-induced acute liver damage in rats.

    PubMed

    Bhadauria, Monika; Nirala, Satendra Kumar; Shukla, Sangeeta

    2007-01-01

    Propolis is a natural product produced by bees that was discovered through the study of traditional cures and knowledge of indigenous people throughout the world. It is rich in vitamins A, B, C, and E, and in amino acids, copper, iron, manganese, and zinc. The investigators studied the duration-dependent hepatoprotective effects of propolis extract (200 mg/kg, orally) against carbon tetrachloride (CCl 4; 1.5 mL/kg, intraperitoneally)-induced liver damage in rats. Administration of CCl 4 caused a sharp elevation in the activity of serum transaminases and serum alkaline phosphatase. A significant depletion in hepatically reduced glutathione was observed with significantly enhanced hepatic lipid peroxidation. After CCl 4 administration, glycogen contents and activities of alkaline phosphatase, adenosine triphosphatase, and succinic dehydrogenase were significantly decreased, whereas total protein contents and activity of acid phosphatase were increased in the liver and kidney. Propolis extract reversed alterations in all parameters when administered within 6, 12, and 24 h of toxicant exposure. Propolis therapy produced duration-dependent protection, with maximal protection achieved at 24 h after CCl 4 exposure. It is believed that propolis in its natural form has general pharmacologic value and marked hepatoprotective potential because of its composition of minerals, flavonoids, and phenolic compounds. PMID:18029340

  20. A Review on Hepatoprotective and Immunomodulatory Herbal Plants

    PubMed Central

    Ilyas, Uorakkottil; Katare, Deepshikha P.; Aeri, Vidhu; Naseef, Punnooth Poonguzi

    2016-01-01

    The liver is the most important organ that plays an important role in maintaining various physiological processes in the body. Hepatitis is an inflammation of the liver and is characterized by the presence of inflammatory cells in the tissue of the organ. There are five main viruses, referred to as types A, B, C, D, and E. These five types are of the greatest concern because of the burden of illness and death. Liver injury or liver dysfunction is a major health problem that challenges not only health care professionals but also the drug regulatory agencies and the pharmaceutical industry. Herbal medicines have been used in the treatment of liver disease for a long time. The immune system is the part of body that diagnoses the pathogen by using a specific receptor to reveal immediate response by the activation of immune components cells, chemokines, and cytokines, and also the release of the inflammatory mediator. They potentiate and modulate the immune system. The plant-derived phytoconstituents (polysaccharides, proteins and flavanoids, lignans, rotenoids, etc.) stimulate the immune system and maintained hepatic diseases. There are a number of hepatoprotective and immunomodulatory herbs that have been reported. The present review is aimed at compiling data on promising phytochemicals from hepatoprotective and immunomodulatory herbs. PMID:27041876

  1. Hepatoprotective effect of aged black garlic extract in rodents.

    PubMed

    Shin, Jung Hyu; Lee, Chang Woo; Oh, Soo Jin; Yun, Jieun; Kang, Moo Rim; Han, Sang-Bae; Park, Heungsik; Jung, Jae Chul; Chung, Yoon Hoo; Kang, Jong Soon

    2014-03-01

    In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury. PMID:24795800

  2. Hepatoprotective actions of melatonin: Possible mediation by melatonin receptors

    PubMed Central

    Mathes, Alexander M

    2010-01-01

    Melatonin, the hormone of darkness and messenger of the photoperiod, is also well known to exhibit strong direct and indirect antioxidant properties. Melatonin has previously been demonstrated to be a powerful organ protective substance in numerous models of injury; these beneficial effects have been attributed to the hormone’s intense radical scavenging capacity. The present report reviews the hepatoprotective potential of the pineal hormone in various models of oxidative stress in vivo, and summarizes the extensive literature showing that melatonin may be a suitable experimental substance to reduce liver damage after sepsis, hemorrhagic shock, ischemia/reperfusion, and in numerous models of toxic liver injury. Melatonin’s influence on hepatic antioxidant enzymes and other potentially relevant pathways, such as nitric oxide signaling, hepatic cytokine and heat shock protein expression, are evaluated. Based on recent literature demonstrating the functional relevance of melatonin receptor activation for hepatic organ protection, this article finally suggests that melatonin receptors could mediate the hepatoprotective actions of melatonin therapy. PMID:21182223

  3. Energy saving potential of residential HVAC options at Fort Irwin, California

    SciTech Connect

    Hadley, D.L.; Stucky, D.J.

    1995-03-01

    The Pacific Northwest Laboratory (PNL) evaluated heating and cooling system options for existing family housing at Fort Irwin, California. The purpose of this work was to quantify the energy conservation potential of alternative system types and to identify the most cost-effective technology available. The conventional residential heating/cooling systems at Fort Irwin are separate propane forced-air furnaces and central air conditioners. The options examined included air- and ground-source heat pumps, a natural gas furnace with central air conditioning, and a natural-gas-fired heat pump. The most cost-effective technology applicable to Fort Irwin was found to be the high-efficiency ground-source heat pumps. If all conventional units were replaced immediately, the net energy savings would be 76,660 MBtu (80.9 TJ) per year and a reduction in electrical demand of approximately 15,000 kW-month. The initial investment for implementing this technology would be approximately $7.1 million, with a savings-to-investment ratio of 1.74.

  4. Energy saving due to natural ventilation in housing blocks in Madrid

    NASA Astrophysics Data System (ADS)

    González-Lezcano, RA; Hormigos-Jiménez, S.

    2016-07-01

    Getting a healthy and comfortable indoor environment in homes in southern Europe is a complicated task. In continental climates, with very cold temperatures in winter and very hot in summer, energy consumption greatly increases with air conditioning significant spending. To propose action guidelines for use of natural ventilation and to develop effective design strategies is essential. Therefore, and given a specific building type block of flats in Madrid, this article focuses on establishing what periods of the year natural ventilation is required to reduce energy consumption in air conditioning, also considering the quality of the outdoor environment and the design of the building. To develop this, a statistical study of the chosen type, that allows studying the direction and the wind speed in the area, is performed. Analysis of wind pressures in holes in the facade is performed by means of numerical simulations of fluid flow (CFD) inside to later infer in the natural ventilation rate required within policy parameters. With the data obtained, a study of energy saving is made as a function of natural ventilation rate established for the building type.

  5. Energy-saving framework for passive optical networks with ONU sleep/doze mode.

    PubMed

    Van, Dung Pham; Valcarenghi, Luca; Dias, Maluge Pubuduni Imali; Kondepu, Koteswararao; Castoldi, Piero; Wong, Elaine

    2015-02-01

    This paper proposes an energy-saving passive optical network framework (ESPON) that aims to incorporate optical network unit (ONU) sleep/doze mode into dynamic bandwidth allocation (DBA) algorithms to reduce ONU energy consumption. In the ESPON, the optical line terminal (OLT) schedules both downstream (DS) and upstream (US) transmissions in the same slot in an online and dynamic fashion whereas the ONU enters sleep mode outside the slot. The ONU sleep time is maximized based on both DS and US traffic. Moreover, during the slot, the ONU might enter doze mode when only its transmitter is idle to further improve energy efficiency. The scheduling order of data transmission, control message exchange, sleep period, and doze period defines an energy-efficient scheme under the ESPON. Three schemes are designed and evaluated in an extensive FPGA-based evaluation. Results show that whilst all the schemes significantly save ONU energy for different evaluation scenarios, the scheduling order has great impact on their performance. In addition, the ESPON allows for a scheduling order that saves ONU energy independently of the network reach.

  6. Approaches to 30% Energy Savings at the Community Scale in the Hot-Humid Climate

    SciTech Connect

    Thomas-Rees, S.; Beal, D.; Martin, E.; Fonorow, K.

    2013-03-01

    BA-PIRC has worked with several community-scale builders within the hot humid climate zone to improve performance of production, or community scale, housing. Tommy Williams Homes (Gainesville, FL), Lifestyle Homes (Melbourne, FL), and Habitat for Humanity (various locations, FL) have all been continuous partners of the BA Program and are the subjects of this report to document achievement of the Building America goal of 30% whole house energy savings packages adopted at the community scale. The scope of this report is to demonstrate achievement of these goals though the documentation of production-scale homes built cost-effectively at the community scale, and modeled to reduce whole-house energy use by 30% in the Hot Humid climate region. Key aspects of this research include determining how to evolve existing energy efficiency packages to produce replicable target savings, identifying what builders' technical assistance needs are for implementation and working with them to create sustainable quality assurance mechanisms, and documenting the commercial viability through neutral cost analysis and market acceptance. This report documents certain barriers builders overcame and the approaches they implemented in order to accomplish Building America (BA) Program goals that have not already been documented in previous reports.

  7. Lighting energy savings potential of split-pane electrochromic windows controlled for daylighting with visual comfort

    SciTech Connect

    Software, Anyhere; Fernandes, Luis; Lee, Eleanor; Ward, Greg

    2013-03-15

    A simulation study was conducted to evaluate lighting energy savings of split-pane electrochromic (EC) windows controlled to satisfy key visual comfort parameters. Using the Radiance lighting simulation software, interior illuminance and luminance levels were computed for a south-facing private office illuminated by a window split into two independently-controlled EC panes. The transmittance of these was optimized hourly for a workplane illuminance target while meeting visual comfort constraints, using a least-squares algorithm with linear inequality constraints. Blinds were successively deployed until visual comfort criteria were satisfied. The energy performance of electrochromics proved to be highly dependent on how blinds were controlled. With hourly blind position adjustments, electrochromics showed significantly higher (62percent and 53percent, respectively without and with overhang) lighting energy consumption than clear glass. With a control algorithm designed to better approximate realistic manual control by an occupant, electrochromics achieved significant savings (48percent and 37percent, respectively without and with overhang). In all cases, energy consumption decreased when the workplace illuminance target was increased. In addition, the fraction of time during which the occupant had an unobstructed view of the outside was significantly greater with electrochromics: 10 months out of the year versus a handful of days for the reference case.

  8. First Results of Energy Saving at Process Redesign of Die Forging Al-Alloys

    SciTech Connect

    Pepelnjak, Tomaz; Kuzman, Karl; Kokol, Anton

    2011-05-04

    The contribution deals with eco-friendly solutions for shortened production chains of forging light alloys. During the die forging operations a remarkable amount of material goes into the flash and later on into chips during finish machining. These low value side products are rich with embedded energy therefore recycling or reprocessing could be very energy saving procedure.In cooperation with a die forging company a shortened reprocessing cycle has been studied starting from re-melting the forging flash and without additional heating to cast preforms for subsequent die forging. As such preforms have not as good formability characteristics as those done from extruded billets the isothermal forging process has been adopted. First results showed that without cracks and other defects the formability is sufficient for a broad spectrum of forgings.To improve the formability a homogenization process of cast preforms has been implemented. As the process started immediately after casting, amount of additional energy for heating was minimized. To reduce voids forging process was redesigned in a way to assure greater hydrostatic pressures in parts during forging. First results were promising therefore research is going towards improving processes without adding significantly more energy as it is needed for casting with homogenization and die forging.

  9. Greenbelt Homes Pilot Program: Summary of Building Envelope Retrofits, Planned HVAC Equipment Upgrades, and Energy Savings

    SciTech Connect

    Wiehagen, J.; Del Bianco, M.; Mallay, D.

    2015-05-01

    In the fall of 2010, a multiyear pilot energy efficiency retrofit project was undertaken by Greenbelt Homes, Inc, (GHI) a 1,566 home cooperative of circa 1930 and 1940 homes in Greenbelt, Maryland. GHI established this pilot project to serve as a basis for decision making for the rollout of a decade-long community-wide upgrade program that will incorporate energy efficiency improvements to the building envelope and mechanical equipment. It presents a unique opportunity to evaluate and prioritize the wide-range of benefits of high-performance retrofits based on member experience with and acceptance of the retrofit measures implemented during the pilot project. Addressing the complex interactions between benefits, trade-offs, construction methods, project management implications, realistic upfront costs, financing, and other considerations, serves as a case study for energy retrofit projects to include high-performance technologies based on the long-term value to the homeowner. The pilot project focused on identifying the added costs and energy savings benefits of improvements.

  10. Evaluation of aeration energy saving in two modified activated sludge processes.

    PubMed

    Lee, Ingyu; Lim, Honglae; Jung, Byunghun; Colosimo, Mark F; Kim, Hyunook

    2015-12-01

    A variety of modified activated sludge processes are widely used in wastewater treatment plants (WWTPs) for removing organics and nutrients (N and P). Since energy consumption in aeration basin accounts for the major part of the overall energy usage in WWTPs, efforts have been made to find ways to reduce aeration energy. In this study, two modified activated sludge processes in a pilot scale designed for nutrient removal were evaluated for the extent of energy saving: (1) ABA(2) process - adjusting air on/off period (i.e., with a temporal change); and (2) MB-A(2)O process - changing volume ratio of aerobic tank to anoxic tank (i.e., with a spatial change). For the 1st process, the air on/off period was fixed at 60min/45min with aerobic fraction being 0.57, while for the 2nd process, the aerobic/anoxic volume ratio was reduced from 0.58 to 0.42. The results demonstrate that the effluent COD, TN, NH4(+) and TP concentrations are acceptable while reduced aeration time/volume certainly saves significant energy consumption. To the best of our knowledge, this is 1st attempt to reduce the aeration period or aeration volume to save the aeration energy in these two modified activated sludge processes. The implication of these observations is further discussed.

  11. FEMP fiscal year 1999 ESPC business strategy development summary report[Energy Saving Performance Contract

    SciTech Connect

    KL McMordie-Stoughton; WDM Hunt

    2000-05-04

    The mission of the US Department of Energy's Federal Energy Management Program (FEMP) is to reduce the cost of Government by advancing energy efficiency, water conservation, and the use of solar and other renewable technologies. This is accomplished by creating partnerships, leveraging resources, transferring technology, and providing training and technical guidance and assistance to agencies. Each of these activities is directly related to achieving requirements set forth in the Energy Policy Act of 1992 and the goals that have been established in Executive Order 13123 (June 1999), but also those that are inherent in sound management of Federal financial and personnel resources. The Pacific Northwest National Laboratory (PNNL) supports the FEMP mission in all activity areas. This responsibility includes working with various Federal energy managers to identify, monitor, and evaluate the performance of new energy efficiency technologies suitable for installation at Federal sites. This report provides the results of a Energy Saving Performance Contracting (ESPC) Business Strategy Development project that PNNL conducted for FEMP. The project provides information regarding the development of Federal market scenarios for FEMP Super-ESPC delivery orders. Two market scenarios were developed. The initial scenario resulted in an estimated delivery order target that was much lower than initially estimated in the spring of 1998. The second scenario yielded a lower estimated number of delivery orders. The main difference between these two scenarios was an estimated increase in utility financed projects in the Federal sector.

  12. Energy savings from operation and maintenance training for apartment boiler heating systems

    SciTech Connect

    Tooze, David

    1992-02-01

    The Portland Energy Office provided operation and maintenance (O M) training to the operators of boiler heating systems for ten low-income apartment complexes in the Fall of 1990. This study tracked energy usage before and after O M training to see if savings occurred. Training was provided on both weatherized and non-weatherized apartments to find out if weatherization impacted the amount of O M savings to be obtained. Also, energy savings from the O M training and building shell weatherization are compared. The O M training averaged about four hours per building. Content was adjusted at each site to match needs of the boiler and operator. The Energy Office also provided a boiler tune-up by a service technician. The training stressed low-cost and no-cost measures which operators could either do themselves or hire service help to implement. It also emphasized boiler safety. Nine of the ten apartment complexes in the study used less energy per heating degree-day after the O M help. Average savings were 10%. Four apartments chosen randomly as controls had negative savings; they used slightly more energy during the same post-O M time frame. Weatherized and unweatherized apartments showed similar savings after the O M help, 10% and 11% percent respectively. Savings from weatherization of six of the apartments in the winter of 1988--1989 were also measured. A low average of only 4% was observed, reflecting negative savings in two buildings.

  13. The conservation nexus: valuing interdependent water and energy savings in Arizona.

    PubMed

    Bartos, Matthew D; Chester, Mikhail V

    2014-02-18

    Water and energy resources are intrinsically linked, yet they are managed separately--even in the water-scarce American southwest. This study develops a spatially explicit model of water-energy interdependencies in Arizona and assesses the potential for cobeneficial conservation programs. The interdependent benefits of investments in eight conservation strategies are assessed within the context of legislated renewable energy portfolio and energy efficiency standards. The cobenefits of conservation are found to be significant. Water conservation policies have the potential to reduce statewide electricity demand by 0.82-3.1%, satisfying 4.1-16% of the state's mandated energy-efficiency standard. Adoption of energy-efficiency measures and renewable generation portfolios can reduce nonagricultural water demand by 1.9-15%. These conservation cobenefits are typically not included in conservation plans or benefit-cost analyses. Many cobenefits offer negative costs of saved water and energy, indicating that these measures provide water and energy savings at no net cost. Because ranges of costs and savings for water-energy conservation measures are somewhat uncertain, future studies should investigate the cobenefits of individual conservation strategies in detail. Although this study focuses on Arizona, the analysis can be extended elsewhere as renewable portfolio and energy efficiency standards become more common nationally and internationally.

  14. Measured energy savings of an energy-efficient office computer system

    SciTech Connect

    Lapujade, P.G.

    1995-12-01

    Recent surveys have shown that the use of personal computer systems in commercial office buildings is expanding rapidly. In warmer climates, office equipment energy use also has important implications for building cooling loads as well as those directly associated with computing tasks. The U.S. Environmental Protection Agency (EPA) has developed the Energy Star (ES) rating system, intended to endorse more efficient machines. To research the comparative performance of conventional and low-energy computer systems, a test was conducted with the substitution of an ES computer system for the main clerical computer used at a research institution. Separate data on power demand (watts), power factor for the computer/monitor, and power demand for the dedicated laser printer were recorded every 15 minutes to a multichannel datalogger. The current system, a 486DX, 66 MHz computer (8 MB of RAM, and 340 MB hard disk) with a laser printer was monitored for an 86-day period. An ES computer and an ES printer with virtually identical capabilities were then substituted and the changes to power demand and power factor were recorded for an additional 86 days. Computer and printer usage patterns remained essentially constant over the entire monitoring period. The computer user was also interviewed to learn of any perceived shortcomings of the more energy-efficient system. Based on the monitoring, the ES computer system is calculated to produce energy savings of 25.8% (121 kWh) over one year.

  15. A self-sensing approach to the energy-saving operation of electromagnetic locking devices

    NASA Astrophysics Data System (ADS)

    Babakeshizadeh, Vahid; Jeon, Soo; McMillan, Ryan

    2014-05-01

    This paper reports an energy-efficient operation of electromagnetic (EM) locking devices using the inductive self-sensing technique, i.e. employing the existing actuation coil as a sensing medium. EM locking devices such as EM locks and locking solenoids have been increasingly used as new security devices in industrial and commercial buildings due to their fully electronic operation. One of the drawbacks of such EM devices is that a significant amount of energy is often wasted through their continual use, especially in applications where the maximum holding power is seldom needed. The main idea of this paper is to operate an EM locking device in such a way that its full power is supplied only when needed. More specifically, we propose running the existing coil as an inductive sensor using significantly less power during normal operation. Any imminent attempt to disengage an EM lock can be instantly detected by the self-sensing coil and its full locking power can then be engaged to prevent it from unlocking. This paper presents a detailed electromagnetic analysis for the self-sensing functionality of the existing EM lock. Besides, a stochastic detection method called the generalized likelihood ratio test (GLRT) has been implemented to improve the energy-saving operation of the EM device. Proposed strategies are experimentally verified using a commercial EM lock, which demonstrated that more than 75% of the original power can be saved by the proposed method while keeping the same locking performance.

  16. Hepatoprotective activity of Abutilon indicum on experimental liver damage in rats.

    PubMed

    Porchezhian, E; Ansari, S H

    2005-01-01

    The aqueous extract of Abutilon indicum was tested for hepatoprotective activity against carbon tetrachloride- and paracetamol-induced hepatotoxicities in rats. A. indicum exhibited significant hepatoprotective activity by reducing carbon tetrachloride- and paracetamol-induced change in bio-chemical parameters that was evident by enzymatic examination. The plant extract may interfere with free-radical formation, which may conclude in hepatoprotective action. Acute toxicity studies revealed that the LD50 value is more than the dose of 4 g/kg body wt. PMID:15693709

  17. Literature Review of the Potential Energy Savings and Retention Water from Green Roofs in Comparison with Conventional Ones

    NASA Astrophysics Data System (ADS)

    Tselekis, Kyriakoulis

    2012-09-01

    The objective of this study is the comparison of green roof systems with conventional isolated and non-isolated ones in order to identify the potential energy savings of green roofs and the benefits provided in comparison with the cost of construction to the buildings. The region of interest is the Watergraafsmeer area in the city of Amsterdam. The method evaluates literature reports - mostly from 2003 to 2010 - that present the advantages of green roofs. Examples in real implementation of green roofs in USA, UK and Germany, retention of rainfall and a Life Cycle Assessment from a residential construction in Madrid will be introduced, showing the energy savings from insulation and heating/cooling that can be gained. All the reports have shown a reduction in energy costs and in runoff of water. Hence, costs and retrofitting potential completes the research. The age of buildings and the absence of insulation make green roofs an ideal alternative project for the retrofit of Watergraafsmeer.

  18. An energy-saving glutathione production method from low-temperature cooked rice using amylase-expressing Saccharomyces cerevisiae.

    PubMed

    Hara, Kiyotaka Y; Kim, Songhee; Kiriyama, Kentaro; Yoshida, Hideyo; Arai, Shogo; Ishii, Jun; Ogino, Chiaki; Fukuda, Hideki; Kondo, Akihiko

    2012-05-01

    Glutathione is a valuable tripeptide that is widely used in the pharmaceutical, food, and cosmetic industries. Glutathione is industrially produced by fermentation using Saccharomyces cerevisiae. Before the glutathione fermentation process with S. cerevisiae, a glucose extraction process from starchy materials is required. This glucose extraction is usually carried out by converting starchy materials to starch using high-temperature cooking and subsequent hydrolysis by amylases to convert starch to glucose. In this study, to develop an energy-saving glutathione production process by reducing energy consumption during the cooking step, we efficiently produced glutathione from low-temperature cooked rice using amylase-expressing S. cerevisiae. The combination of the amylase-expressing yeast with low-temperature cooking is potentially applicable to a variety of energy-saving bio-production methods of chemicals from starchy bio-resources. PMID:22294378

  19. Evaluation of Energy Saving Characteristics of a High-Efficient Cogeneration System Utilizing Gas Engine Exhaust Heat

    NASA Astrophysics Data System (ADS)

    Pak, Pyong Sik

    A high efficiency cogeneration system (CGS) utilizing high temperature exhaust gas from a gas engine is proposed. In the proposed CGS, saturated steam produced in the gas engine is superheated with a super heater utilizing regenerative burner and used to drive a steam turbine generator. The heat energy is supplied by extracting steam from the steam turbine and turbine outlet low-temperature steam. Both of the energy saving characteristics of the proposed CGS and a CGS constructed by using the original gas engine (GE-CGS) were investigated and compared, by taking a case where energy for office buildings was supplied by the conventional energy systems. It was shown that the proposed CGS has energy saving rate of 24.5%, higher than 1.83 times, compared with that of the original GE-CGS.

  20. Building America Residential System Research Results: Achieving 30% Whole House Energy Savings Level in Marine Climates; January 2006 - December 2006

    SciTech Connect

    Building America Industrialized Housing Partnership; Building Industry Research Alliance; Building Science Consortium; Consortium for Advanced Residential Buildings; Davis Energy Group; IBACOS; National Association of Home Builders Research Center; National Renewable Energy Laboratory

    2006-12-01

    The Building America program conducts the system research required to reduce risks associated with the design and construction of homes that use an average of 30% to 90% less total energy for all residential energy uses than the Building America Research Benchmark, including research on homes that will use zero net energy on annual basis. To measure the program's progress, annual research milestones have been established for five major climate regions in the United States. The system research activities required to reach each milestone take from 3 to 5 years to complete and include research in individual test houses, studies in pre-production prototypes, and research studies with lead builders that provide early examples that the specified energy savings level can be successfully achieved on a production basis. This report summarizes research results for the 30% energy savings level and demonstrates that lead builders can successfully provide 30% homes in the Marine Climate Region on a cost neutral basis.

  1. Technical Support Document: Development of the Advanced Energy Design Guide for Medium to Big Box Retail Buildings - 50% Energy Savings

    SciTech Connect

    Bonnema, E.; Leach, M.; Pless, S.

    2013-06-01

    This Technical Support Document describes the process and methodology for the development of the Advanced Energy Design Guide for Medium to Big Box Retail Buildings: Achieving 50% Energy Savings Toward a Net Zero Energy Building (AEDG-MBBR) ASHRAE et al. (2011b). The AEDG-MBBR is intended to provide recommendations for achieving 50% whole-building energy savings in retail stores over levels achieved by following ANSI/ASHRAE/IESNA Standard 90.1-2004, Energy Standard for Buildings Except Low-Rise Residential Buildings (Standard 90.1-2004) (ASHRAE 2004b). The AEDG-MBBR was developed in collaboration with the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE), the American Institute of Architects (AIA), the Illuminating Engineering Society of North America (IES), the U.S. Green Building Council (USGBC), and the U.S. Department of Energy.

  2. Technical Support Document: Development of the Advanced Energy Design Guide for Medium to Big Box Retail Buildings - 50% Energy Savings

    SciTech Connect

    Bonnema, Eric; Leach, Matt; Pless, Shanti

    2013-06-05

    This Technical Support Document describes the process and methodology for the development of the Advanced Energy Design Guide for Medium to Big Box Retail Buildings: Achieving 50% Energy Savings Toward a Net Zero Energy Building (AEDG-MBBR) ASHRAE et al. (2011b). The AEDG-MBBR is intended to provide recommendations for achieving 50% whole-building energy savings in retail stores over levels achieved by following ANSI/ASHRAE/IESNA Standard 90.1-2004, Energy Standard for Buildings Except Low-Rise Residential Buildings (Standard 90.1-2004) (ASHRAE 2004b). The AEDG-MBBR was developed in collaboration with the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE), the American Institute of Architects (AIA), the Illuminating Engineering Society of North America (IES), the U.S. Green Building Council (USGBC), and the U.S. Department of Energy.

  3. An energy-saving glutathione production method from low-temperature cooked rice using amylase-expressing Saccharomyces cerevisiae.

    PubMed

    Hara, Kiyotaka Y; Kim, Songhee; Kiriyama, Kentaro; Yoshida, Hideyo; Arai, Shogo; Ishii, Jun; Ogino, Chiaki; Fukuda, Hideki; Kondo, Akihiko

    2012-05-01

    Glutathione is a valuable tripeptide that is widely used in the pharmaceutical, food, and cosmetic industries. Glutathione is industrially produced by fermentation using Saccharomyces cerevisiae. Before the glutathione fermentation process with S. cerevisiae, a glucose extraction process from starchy materials is required. This glucose extraction is usually carried out by converting starchy materials to starch using high-temperature cooking and subsequent hydrolysis by amylases to convert starch to glucose. In this study, to develop an energy-saving glutathione production process by reducing energy consumption during the cooking step, we efficiently produced glutathione from low-temperature cooked rice using amylase-expressing S. cerevisiae. The combination of the amylase-expressing yeast with low-temperature cooking is potentially applicable to a variety of energy-saving bio-production methods of chemicals from starchy bio-resources.

  4. Evaluation of Modeled and Measured Energy Savings in Existing All Electric Public Housing in the Pacific Northwest

    SciTech Connect

    Gordon, Andrew; Lubliner, Michael; Howard, Luke; Kunkle, Rick; Salzberg, Emily

    2014-04-01

    This project analyzes the cost effectiveness of energy savings measures installed by a large public housing authority in Salishan, a community in Tacoma Washington. Research focuses on the modeled and measured energy usage of the first six phases of construction, and compares the energy usage of those phases to phase 7. Market-ready energy solutions were also evaluated to improve the efficiency of affordable housing for new and existing (built since 2001) affordable housing in the marine climate of Washington State.

  5. Energy-saving conditions for electric melting of prereduced pellets in the bath of an arc furnace

    NASA Astrophysics Data System (ADS)

    Merker, E. E.; Chermenev, E. A.; Stepanov, V. A.

    2015-06-01

    The problems of increasing the efficiency of electric steelmaking under the application of tubular (hollow) electrodes for supplying iron ore prereduced pellets directly to the high-temperature zone on the surface of a liquid metal are considered. It is shown that the use of an energy-saving regime based on the developed algorithm for the new method of charging pellets makes it possible to decrease the metal losses and to increase the energy efficiency of electric steelmaking.

  6. Evaluating Energy Savings in All-Electric Public Housing in the Pacific Northwest, Tacoma, Washington (Fact Sheet)

    SciTech Connect

    Not Available

    2014-03-01

    This project analyzes the cost effectiveness of energy savings measures installed by a large public housing authority in Salishan, a community in Tacoma Washington. Research focuses on the modeled and measured energy usage of the first six phases of construction, and compares the energy usage of those phases to phase 7. Market-ready energy solutions were also evaluated to improve the efficiency of affordable housing for new and existing (built since 2001) affordable housing in the marine climate of Washington State.

  7. Federal Energy Management Program (FEMP): What`s new in federal energy management: Program overview: Energy savings performance contracting

    SciTech Connect

    1996-08-01

    The Energy Policy Act of 1992 and Executive Order 12902 require that Federal agencies reduce the energy consumed in Federal buildings. Goal was increased to 30% by 2005, compared with 1985. Energy Savings Performance Contracting (ESPC) offers a means of achieving this energy reduction goal at no capital cost to the government. ESPC is an alternative to the traditional method of financing energy efficiency improvement in Federal buildings; it involves contracting with energy service companies.

  8. Effects of a behaviour change intervention for Girl Scouts on child and parent energy-saving behaviours

    NASA Astrophysics Data System (ADS)

    Boudet, Hilary; Ardoin, Nicole M.; Flora, June; Armel, K. Carrie; Desai, Manisha; Robinson, Thomas N.

    2016-08-01

    Energy education programmes for children are hypothesized to have great potential to save energy. Such interventions are often assumed to impact child and family behaviours. Here, using a cluster-randomized controlled trial with 30 Girl Scout troops in Northern California, we assess the efficacy of two social cognitive theory-based interventions focused on residential and food-and-transportation energy-related behaviours of Girl Scouts and their families. We show that Girl Scouts and parents in troops randomly assigned to the residential energy intervention significantly increased their self-reported residential energy-saving behaviours immediately following the intervention and after more than seven months of follow-up, compared with controls. Girl Scouts in troops randomly assigned to the food-and-transportation energy intervention significantly increased their self-reported food-and-transportation energy-saving behaviours immediately following the intervention, compared with controls, but not at follow-up. The results demonstrate that theory-based, child-focused energy interventions have the potential to increase energy-saving behaviours among both children and their parents.

  9. Energy Saving Melting and Revert Reduction Technology (Energy SMARRT): Development of CCT Diagrams

    SciTech Connect

    Chumbley, L Scott

    2011-08-20

    goal of this study was to accurately characterize the solid-solid phase transformations seen in cast superaustenitic stainless steels. Heat treatments were performed to understand the time and temperature ranges for intermetallic phase formations in alloys CN3MN and CK3McuN. Microstructures were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy and wavelength dispersive spectroscopy (EDS, WDS). In this way TTT and CCT diagrams could be developed for the matrix of samples chosen. As this study consisted of basic research into the development of TTT and CCT diagrams as an aid to the US steel casting industry, there is no formal commercialization plan associated with this task other than presentations and publications via the Steel Founders Society of America to their members. The author is confident that the data contained in this report can be used by steel foundries to refine their casting procedures in such a way as to reduce the amount of waste produced and energy wasted by significantly reducing or eliminating the need for remelting or recasting of material due to unwanted, premature intermetallic formation. This development of high alloy steel CCT diagrams was predicted to result in an average energy savings of 0.05 trillion BTU's/year over a 10 year period (with full funding). With 65% of the proposed funding, current (2011) annual energy saving estimates, based on initial dissemination to the casting industry in 2011and market penetration of 97% by 2020, is 0.14 trillion BTU's/year. The reduction of scrap and improvement in casting yield will also result in a reduction of environmental emissions associated with the melting and pouring of the steel. The average annual estimate of CO2 reduction per year through 2020 is 0.003 Million Metric Tons of Carbon Equivalent (MM TCE)

  10. A Study of the Energy-Saving Potential of Metal Roofs Incorporating Dynamic Insulation Systems

    SciTech Connect

    Biswas, Kaushik; Miller, William A; Kriner, Scott; Manlove, Gary

    2013-01-01

    This article presents various metal roof configurations that were tested at Oak Ridge National Laboratory in Tennessee, U.S. between 2009 and 2013, and describes their potential for reducing the attic-generated space-conditioning loads. These roofs contained different combinations of phase-change material, rigid insulation, low emittance surface, and above-sheathing ventilation with standing-seam metal panels on top. These roofs were designed to be installed on existing roofs decks, or on top of asphalt shingles for retrofit construction. All the tested roofs showed the potential for substantial energy savings compared to an asphalt shingle roof, which was used as a control for comparison. The roofs were constructed on a series of adjacent attics separated at the gables using thick foam insulation. The attics were built on top of a conditioned room. All attics were vented at the soffit and ridge. The test roofs and attics were instrumented with an array of thermocouples. Heat flux transducers were installed in the roof deck and attic floor (ceiling) to measure the heat flows through the roof and between the attic and conditioned space below. Temperature and heat flux data were collected during the heating, cooling and swing seasons over a three-year period. Data from previous years of testing have been published. Here, data from the latest roof configurations being tested in year three of the project are presented. All test roofs were highly effective in reducing the heat flows through the roof and ceiling, and in reducing the diurnal attic-temperature fluctuations.

  11. Mitochondrial phenotypic flexibility enhances energy savings during winter fast in king penguin chicks.

    PubMed

    Monternier, Pierre-Axel; Marmillot, Vincent; Rouanet, Jean-Louis; Roussel, Damien

    2014-08-01

    Energy conservation is a key priority for organisms that live in environments with seasonal shortages in resource supplies or that spontaneously fast during their annual cycle. The aim of this study was to determine whether the high fasting endurance of winter-acclimatized king penguin chicks (Aptenodytes patagonicus) is associated with an adjustment of mitochondrial bioenergetics in pectoralis muscle, the largest skeletal muscle in penguins. The rates of mitochondrial oxygen consumption, and ATP synthesis and mitochondrial efficiency (ATP/O ratio) were measured in winter-acclimatized chicks. We used pyruvate/malate and palmitoyl-l-carnitine/malate as respiratory substrates and results from naturally fasted chicks were compared to experimentally re-fed chicks. Bioenergetics analysis of pectoralis muscle revealed that mitochondria are on average 15% more energy efficient in naturally fasted than in experimentally fed chicks, indicating that fasted birds consume less nutrients to sustain their energy-demanding processes. We also found that moderate reductions in temperature from 38°C to 30°C further increase by 23% the energy coupling efficiency at the level of mitochondria, suggesting that king penguin chicks realize additional energy savings while becoming hypothermic during winter. It has been calculated that this adjustment of mitochondrial efficiency in skeletal muscle may contribute to nearly 25% of fasting-induced reduction in mass-specific metabolic rate measured in vivo. The present study shows that the regulation of mitochondrial efficiency triggers the development of an economical management of resources, which would maximize the conservation of endogenous fuel stores by decreasing the cost of living in fasted winter-acclimatized king penguin chicks. PMID:24803465

  12. Energy Savings Potential of Flexible and Adaptive HVAC Distribution Systems for Office Buildings

    SciTech Connect

    Loftness, Vivian; Brahme, Rohini; Mondazzi, Michelle; Vineyard, Edward; MacDonald, Michael

    2002-06-01

    . Architects, professional engineers, and commercial real estate developers will benefit from the availability of information that quantifies energy savings, first cost construction differences, and additional operating costs created when office space must be reconfigured to accommodate new tenants.

  13. Modeling Urban Energy Savings Scenarios using Earth System Microclimate and Urban Morphology

    NASA Astrophysics Data System (ADS)

    Allen, M. R.; Rose, A. N.; Branstetter, M. L.; Yuan, J.; New, J. R.; Omitaomu, O.; Wilbanks, T. J.

    2015-12-01

    In anticipation of emerging global urbanization, better understanding and quantification of climate effects on energy use are needed, requiring coordinated research of microclimate impacts on and from "human systems." To this end, we analyze and quantify the relationships among climatic conditions, urban morphology, population, land cover, and energy use so that these relationships can be used to inform energy-efficient urban development and planning. The focus of this research is on the analysis of measured and modeled energy efficiency of various building types in selected urban areas and temporal variations in energy use for different morphologies under different microclimatic conditions; implications for different morphologies of future climate and urban growth scenarios; and potential energy projections and savings by morphology for selected climatically distinct US cities. This work considers population projections to inform morphological design by incorporating two new datasets in which these projections have been made for years 2030 and 2050 at 30 arc-second resolution, in order to determine potential siting and design of new urban development. The overarching objective is the integration of different approaches across three research areas: earth system modeling; impacts, adaptation and vulnerability; and urban planning in order to address three major gaps in the existing capability in these areas: i) neighborhood resolution modeling and simulation of urban micrometeorological processes and their effect on and from regional climate; ii) projections for future energy use under urbanization and climate change scenarios identifying best strategies for urban morphological development and energy savings; iii) analysis and visualization tools to help planners optimally use these projections.

  14. Energy Saving Potentials and Air Quality Benefits of Urban Heat Island Mitigation

    SciTech Connect

    Akbari, Hashem

    2005-08-23

    Urban areas tend to have higher air temperatures than their rural surroundings as a result of gradual surface modifications that include replacing the natural vegetation with buildings and roads. The term ''Urban Heat Island'' describes this phenomenon. The surfaces of buildings and pavements absorb solar radiation and become extremely hot, which in turn warm the surrounding air. Cities that have been ''paved over'' do not receive the benefit of the natural cooling effect of vegetation. As the air temperature rises, so does the demand for air-conditioning (a/c). This leads to higher emissions from power plants, as well as increased smog formation as a result of warmer temperatures. In the United States, we have found that this increase in air temperature is responsible for 5-10% of urban peak electric demand for a/c use, and as much as 20% of population-weighted smog concentrations in urban areas. Simple ways to cool the cities are the use of reflective surfaces (rooftops and pavements) and planting of urban vegetation. On a large scale, the evapotranspiration from vegetation and increased reflection of incoming solar radiation by reflective surfaces will cool a community a few degrees in the summer. As an example, computer simulations for Los Angeles, CA show that resurfacing about two-third of the pavements and rooftops with reflective surfaces and planting three trees per house can cool down LA by an average of 2-3K. This reduction in air temperature will reduce urban smog exposure in the LA basin by roughly the same amount as removing the basin entire onroad vehicle exhaust. Heat island mitigation is an effective air pollution control strategy, more than paying for itself in cooling energy cost savings. We estimate that the cooling energy savings in U.S. from cool surfaces and shade trees, when fully implemented, is about $5 billion per year (about $100 per air-conditioned house).

  15. Mitochondrial phenotypic flexibility enhances energy savings during winter fast in king penguin chicks.

    PubMed

    Monternier, Pierre-Axel; Marmillot, Vincent; Rouanet, Jean-Louis; Roussel, Damien

    2014-08-01

    Energy conservation is a key priority for organisms that live in environments with seasonal shortages in resource supplies or that spontaneously fast during their annual cycle. The aim of this study was to determine whether the high fasting endurance of winter-acclimatized king penguin chicks (Aptenodytes patagonicus) is associated with an adjustment of mitochondrial bioenergetics in pectoralis muscle, the largest skeletal muscle in penguins. The rates of mitochondrial oxygen consumption, and ATP synthesis and mitochondrial efficiency (ATP/O ratio) were measured in winter-acclimatized chicks. We used pyruvate/malate and palmitoyl-l-carnitine/malate as respiratory substrates and results from naturally fasted chicks were compared to experimentally re-fed chicks. Bioenergetics analysis of pectoralis muscle revealed that mitochondria are on average 15% more energy efficient in naturally fasted than in experimentally fed chicks, indicating that fasted birds consume less nutrients to sustain their energy-demanding processes. We also found that moderate reductions in temperature from 38°C to 30°C further increase by 23% the energy coupling efficiency at the level of mitochondria, suggesting that king penguin chicks realize additional energy savings while becoming hypothermic during winter. It has been calculated that this adjustment of mitochondrial efficiency in skeletal muscle may contribute to nearly 25% of fasting-induced reduction in mass-specific metabolic rate measured in vivo. The present study shows that the regulation of mitochondrial efficiency triggers the development of an economical management of resources, which would maximize the conservation of endogenous fuel stores by decreasing the cost of living in fasted winter-acclimatized king penguin chicks.

  16. Quadrupedal locomotor performance in two species of arboreal squirrels: predicting energy savings of gliding.

    PubMed

    Flaherty, Elizabeth A; Ben-David, Merav; Smith, Winston P

    2010-10-01

    Gliding allows mammals to exploit canopy habitats of old-growth forests possibly as a means to save energy. To assess costs of quadrupedal locomotion for a gliding arboreal mammal, we used open-flow respirometry and a variable-speed treadmill to measure oxygen consumption and to calculate cost of transport, excess exercise oxygen consumption, and excess post-exercise oxygen consumption for nine northern flying squirrels (Glaucomys sabrinus) and four fox squirrels (Sciurus niger). Our results indicate that oxygen consumption during exercise by flying squirrels was 1.26-1.65 times higher than predicted based on body mass, and exponentially increased with velocity (from 0.84 ± 0.03 ml O(2) kg(-1) s(-1) at 0.40 m s(-1) to 1.55 ± 0.03 ml O(2) kg(-1) s(-1) at 0.67 m s(-1)). Also, cost of transport in flying squirrels increased with velocity, although excess exercise oxygen consumption and excess post-exercise oxygen consumption did not. In contrast, oxygen consumption during exercise for fox squirrels was similar to predicted, varying from 0.51 (±0.02) ml O(2) kg(-1) s(-1) at 0.63 m s(-1) to 0.54 (±0.03) ml O(2) kg(-1) s(-1) at 1.25 m s(-1). In addition, the cost of transport for fox squirrels decreased with velocity, while excess exercise oxygen consumption and excess post-exercise oxygen consumption did not. Collectively, these observations suggest that unlike fox squirrels, flying squirrels are poorly adapted to prolonged bouts of quadrupedal locomotion. The evolution of skeletal adaptations to climbing, leaping, and landing and the development of a gliding membrane likely has increased the cost of quadrupedal locomotion by >50% while resulting in energy savings during gliding and reduction in travel time between foraging patches. PMID:20361193

  17. Energy Saving Method of Manufacturing Ceramic Products from Fiber Glass Waste

    SciTech Connect

    Michael J. Haun

    2005-07-15

    The U.S. fiber glass industry disposes of more than 260,000 tons of industrial fiber glass waste in landfills annually. New technology is needed to reprocess this industrial waste into useful products. A low-cost energy-saving method of manufacturing ceramic tile from fiber glass waste was developed. The technology is based on sintering fiber glass waste at 700-900 degrees C to produce products which traditionally require firing temperatures of >1200 degrees C, or glass-melting temperatures >1500 degrees C. The process also eliminates other energy intensive processing steps, including mining and transportation of raw materials, spray-drying to produce granulated powder, drying pressed tile, and glazing. The technology completely transforms fiber glass waste into a dense ceramic product, so that all future environmental problems in the handling and disposal of the fibers is eliminated. The processing steps were developed and optimized to produce glossy and matte surface finishes for wall and floor tile applications. High-quality prototype tile samples were processed for demonstration and tile standards testing. A Market Assessment confirmed the market potential for tile products produced by the technology. Manufacturing equipment trials were successfully conducted for each step of the process. An industrial demonstration plant was designed, including equipment and operating cost analysis. A fiber glass manufacturer was selected as an industrial partner to commercialize the technology. A technology development and licensing agreement was completed with the industrial partner. Haun labs will continue working to transfer the technology and assist the industrial partner with commercialization beyond the DOE project.

  18. Hepatoprotective and anti-inflammatory effects of a traditional medicinal plant of Chile, Peumus boldus.

    PubMed

    Lanhers, M C; Joyeux, M; Soulimani, R; Fleurentin, J; Sayag, M; Mortier, F; Younos, C; Pelt, J M

    1991-04-01

    Dried hydro-alcoholic extract of Peumus boldus (Monimiaceae) has been evaluated for hepatoprotective, choleretic and anti-inflammatory effects in mice and rats, in order to validate or to invalidate traditional therapeutic indications. This extract exerted a significant hepatoprotection of tert-butyl hydroperoxide-induced hepatotoxicity in isolated rat hepatocytes (in vitro technique) by reducing the lipid peroxidation and the enzymatic leakage of LDH; this in vitro efficacy was reinforced by a significant hepatoprotection on CCl4-induced hepatotoxicity in mice (in vivo technique), the plant extract reducing the enzymatic leakage of ALAT. Boldine, the main alkaloid of P. boldus appears to be implicated in this hepatoprotective activity. Choleretic effects, often mentioned in traditional indications, have not been confirmed in rats. Finally, significant and dose-dependent anti-inflammatory effects were obtained on an acute inflammatory process (carrageenan-induced edema test in rats). Boldine does not appear to be involved in such properties. PMID:1891491

  19. Evidences of hepatoprotective and antioxidant effect of Citrullus colocynthis fruits in paracetamol induced hepatotoxicity.

    PubMed

    Vakiloddin, Syed; Fuloria, Neeraj; Fuloria, Shivkanya; Dhanaraj, Sokkalingam Arumugam; Balaji, Kaveti; Karupiah, Sundram

    2015-05-01

    The objective of present study was to explore the hepatoprotective and antioxidant profile of Citrullus colocynthis fruits. Hepatoprotective profile of methanolic extract of Citrullus colocynthis fruits (MECCF) was investigated on rats, which were made hepatotoxic using paracetamol. The antioxidant profile of MECCF was evaluated by conducting Catalase, Super oxide Dismutase, Lipid Peroxidation and Diphenyl Picryl Hydrazyl tests. During hepatoprotective investigation, the Paracetamol treated group II showed significant increase in total bilirubin (TB), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) level. The results so obtained showed that pretreatment of rats with MECCF 300mg/kg p.o. decreases the elevated TB, SGOT, SGPT and ALP serum levels. Also, MECCF inhibitory profile was found comparable with toxicant group (Paracetamol 2g/kg, p.o.). The present study concludes that MECCF fruit possess significant hepatoprotective and antioxidant activity.

  20. Evidences of hepatoprotective and antioxidant effect of Citrullus colocynthis fruits in paracetamol induced hepatotoxicity.

    PubMed

    Vakiloddin, Syed; Fuloria, Neeraj; Fuloria, Shivkanya; Dhanaraj, Sokkalingam Arumugam; Balaji, Kaveti; Karupiah, Sundram

    2015-05-01

    The objective of present study was to explore the hepatoprotective and antioxidant profile of Citrullus colocynthis fruits. Hepatoprotective profile of methanolic extract of Citrullus colocynthis fruits (MECCF) was investigated on rats, which were made hepatotoxic using paracetamol. The antioxidant profile of MECCF was evaluated by conducting Catalase, Super oxide Dismutase, Lipid Peroxidation and Diphenyl Picryl Hydrazyl tests. During hepatoprotective investigation, the Paracetamol treated group II showed significant increase in total bilirubin (TB), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) level. The results so obtained showed that pretreatment of rats with MECCF 300mg/kg p.o. decreases the elevated TB, SGOT, SGPT and ALP serum levels. Also, MECCF inhibitory profile was found comparable with toxicant group (Paracetamol 2g/kg, p.o.). The present study concludes that MECCF fruit possess significant hepatoprotective and antioxidant activity. PMID:26004728

  1. Energy Saving Melting and Revert Reduction Technology (E-SMARRT): Mechanical Performance of Dies

    SciTech Connect

    R. Allen Miller, Principal Investigator; Kabiri-Bamoradian, Contributors: Khalil; Delgado-Garza, Abelardo; Murugesan, Karthik; Ragab, Adham

    2011-09-13

    provided to NADCA for distribution to the industry. Power law based meta-models for predicting machine tie bar loading and for predicting maximum parting surface separation were successfully developed and tested against simulation results for a wide range of machines and experimental data. The models proved to be remarkably accurate, certainly well within the requirements for practical application. In addition to making die structural modeling more accessible, the work advanced the state-of-the-art by developing improved modeling of cavity pressure effects, which is typically modeled as a hydrostatic boundary condition, and performing a systematic analysis of the influence of ejector die design variables on die deflection and parting plane separation. This cavity pressure modeling objective met with less than complete success due to the limits of current finite element based fluid structure interaction analysis methods, but an improved representation of the casting/die interface was accomplished using a combination of solid and shell elements in the finite element model. This approximation enabled good prediction of final part distortion verified with a comprehensive evaluation of the dimensions of test castings produced with a design experiment. An extra deliverable of the experimental work was development of high temperature mechanical properties for the A380 die casting alloy. The ejector side design objective was met and the results were incorporated into the metamodels described above. This new technology was predicted to result in an average energy savings of 2.03 trillion BTU's/year over a 10 year period. Current (2011) annual energy saving estimates over a ten year period, based on commercial introduction in 2009, a market penetration of 70% by 2014 is 4.26 trillion BTU's/year by 2019. Along with these energy savings, reduction of scrap and improvement in casting yield will result in a reduction of the environmental emissions associated with the melting and pouring

  2. Evaluation of Iyengariastellata for its hypolipidemic and hepatoprotective activity.

    PubMed

    Riaz, Bushra; Najam, Rahila; Anser, Humera; Ali, Muhammad Shaiq

    2014-11-01

    Cholesterol is believed to be the major regulator involved in the formation and progression of atheroma plaque. Seaweeds are known to possess enormous biological activities. They contain variety of active constituents, which have pharmacological significance. The objective of this study is to explore hypolipidemic and hepatoprotective activities of the brown seaweed Iyengariastellata. Ethanolic extract of seaweed was suspended in distilled water and administered orally at 10mg/200g body weight to rabbits for 30 days and total lipid level, cholesterol, triglycerides, HDL, LDL, VLDL, alkaline phosphatase, SGPT, SGOT, Gamma GT were assessed. The results showed overall decrease in lipid profile whereas Iyengariastellata increased liver enzymes except SGPT which was decreased highly significantly, since SGPT is more specific indicator of liver injury, decreased value of SGPT indicates that Iyengariastellata toxicity is less severe and reversible with marked hypolipidemic effect, but during the course of ingestion of the seaweed the liver enzymes must be carefully monitored to ensure liver safety.

  3. Chemical composition and hepatoprotective effects of polyphenol-rich extract from Houttuynia cordata tea.

    PubMed

    Tian, Lingmin; Shi, Xiaolong; Yu, Linhong; Zhu, Jiao; Ma, Rui; Yang, Xingbin

    2012-05-01

    This study was designed to investigate the antioxidant activity, hepatoprotective effect, and phenolic composition of the ethyl acetate fraction (EAF) extracted from Houttuynia cordata tea. EAF was shown to exhibit strong ferric-reducing antioxidant power (FRAP) and scavenging activity against DPPH radical in vitro, and the antioxidant effects were further verified by suppressing CCl₄-induced oxidative stress in mouse liver at three tested doses of EAF (250, 500, and 1000 mg/kg bw). Pretreatment with EAF (1000 mg/kg bw) prior to CCl₄ administration significantly (p < 0.001) decreased the CCl₄-elevated levels of serum AST, ALT, alkaline phosphatase, total bilirubin, and hepatic MDA in mice and prevented the increases in GSH, SOD, and CAT caused by CCl₄. HPLC analysis revealed that three predominantly polyphenolic compounds present in EAF were quercitrin (111.7 μg/mg), quercetin (43.8 μg/mg), and hyperoside (29.1 μg/mg). These results combined with liver histopathology indicate that EAF possesses a significant protective effect against acute hepatotoxicity induced by CCl₄, which may be due to the strong antioxidant activity of phenolic components. PMID:22515645

  4. Hepatoprotective effect of propagermanium on Corynebacterium parvum and lipopolysaccharide-induced liver injury in mice.

    PubMed

    Yokochi, S; Ishiwata, Y; Hashimoto, H; Ninomiya, F; Suzuki, T

    1998-08-01

    Propagermanium is an organic germanium compound with immunopotentiating activity. We examined the hepatoprotective effect of propagermanium and its mechanism in an experimental animal model of acute liver injury induced with Corynebacterium parvum (C. parvum) and lipopolysaccharide (LPS) injection. Oral pretreatment with propagermanium decreased alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity in a dose-dependent manner. Significant attenuation of ALT and AST activity was obtained at a dose of 3 mg/kg. Administration of propagermanium also inhibited the infiltration of mononuclear cells into the liver of mice induced by C. parvum/LPS. Immunohistochemical examination revealed infiltration of the liver by CD4-, CD8-, CD11b- and Gr-1-positive cells. Propagermanium prevented CD4- and CD11b-positive cells from infiltrating the liver. In this animal model, blood cytokine levels increased rapidly after LPS injection, causing severe hepatitis. Notably, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) are important mediators of the progress of liver injury. We demonstrated that propagermanium reduced IFN-gamma production by 53% at a dose of 3 mg/kg and also significantly inhibited the production of interleukin-12 (IL-12). These results indicate that propagermanium inhibits cell infiltration in the liver and cytokine production, and improves massive liver injury in C. parvum/LPS mice. PMID:9716110

  5. Building America Residential System Research Results. Achieving 30% Whole House Energy Savings Level in Hot-Dry and Mixed-Dry Climates

    SciTech Connect

    Anderson, R.; Hendron, R.; Eastment, M.; Jalalzadeh-Azar, A.

    2006-01-01

    This report summarizes Building America research results for the 30% energy savings level and demonstrates that lead builders can successfully provide 30% homes in the Hot-Dry/Mixed-Dry Climate Region on a cost-neutral basis.

  6. Building America Residential System Research Results: Achieving 30% Whole House Energy Savings Level in Mixed-Humid Climates; January 2006 - December 2006

    SciTech Connect

    Anderson, R.; Hendron, R.; Eastment, M.; Jalalzadeh-Azar, A.

    2006-12-01

    This report summarizes research results for the 30% energy savings level and demonstrates that lead builders can successfully provide 30% homes in the Mixed-Humid Climate Region on a cost-neutral basis.

  7. Building America Best Practices Series: Builders Challenge Guide to 40% Whole-House Energy Savings in the Marine Climate (Volume 11)

    SciTech Connect

    Pacific Northwest National Laboratory

    2010-09-01

    With the measures described in this guide, builders in the marine climate can build homes that have whole-house energy savings of 40% over the Building America benchmark with no added overall costs for consumers.

  8. Analysis of energy-saving potential in residential buildings in Xiamen City and its policy implications for southern China

    NASA Astrophysics Data System (ADS)

    Guo, Fei

    The buildings sector is the largest energy-consuming sector in the world. Residential buildings consume about three-quarters of the final energy in the buildings sector. Promoting residential energy savings is in consequence critical for addressing many energy-use-related environmental challenges, such as climate change and air pollution. Given China's robust economic growth and fast urbanization, it is now a critical time to develop policy interventions on residential energy use in the nation. With this as a background, this dissertation explores effective policy intervention opportunities in southern China through analyzing the residential energy-saving potential, using the city of Xiamen as a case study. Four types of residential energy-saving potential are analyzed: technical potential, economic potential, maximum achievable potential (MAP), and possible achievable potential (PAP). Of these, the first two types are characterized as static theoretical evaluation, while the last two represent dynamic evaluation within a certain time horizon. The achievable potential analyses are rarely seen in existing literature. The analytical results reveal that there exists a significant technical potential for residential energy savings of about 20.9-24.9% in the city of Xiamen. Of the technical potential, about two-thirds to four-fifths are cost-effective from the government or society perspective. The cost-effectiveness is evaluated by comparing the "Levelized Cost of Conserved Energy (LCOCE)" of available advanced technical measures with the "Actual Cost" of conserved energy. The "Actual Cost" of energy is defined by adding the environmental externalities costs and hidden government subsidies over the retail prices of energy. The achievable potential analyses are particularly based on two key realistic factors: 1) the gradual ramping-up adoption process of advanced technical measures; and 2) individuals' adoption-decision making on them. For implementing the achievable

  9. Low-cost, highly transparent flexible low-e coating film to enable electrochromic windows with increased energy savings

    SciTech Connect

    Berland, Brian; Hollingsworth, Russell

    2015-03-31

    Five Quads of energy are lost through windows annually in the U.S. Low-e coatings are increasingly employed to reduce the wasted energy. Most commonly, the low-e coating is an oxide material applied directly to the glass at high temperature. With over 100,000,000 existing homes, a retrofit product is crucial to achieve widespread energy savings. Low-e films, i.e. coatings on polymeric substrates, are now also available to meet this need. However, the traditional oxide materials and process is incompatible with low temperature plastics. Alternate high performing low-e films typically incorporate materials that limit visible transmission to 35% or less. Further, the cost is high. The objective of this award was to develop a retrofit, integrated low-e/electrochromic window film to dramatically reduce energy lost through windows. While field testing of state-of-the-art electrochromic (EC) windows show the energy savings are maximized if a low-e coating is used in conjunction with the EC, available low-e films have a low visible transmission (~70% or less) that limits the achievable clear state and therefore, appearance and energy savings potential. Comprehensive energy savings models were completed at Lawrence Berkeley National Lab (LBNL). A parametric approach was used to project energy usage for windows with a large range of low-e properties across all U.S. climate zones, without limiting the study to materials that had already been produced commercially or made in a lab. The model enables projection of energy savings for low-e films as well as integrated low-e/EC products. This project developed a novel low-e film, optimized for compatibility with EC windows, using low temperature, high deposition rate processes for the growth of low-e coatings on plastic films by microwave plasma enhanced chemical vapor deposition. Silica films with good density and optical properties were demonstrated at deposition rates as high as 130Å/sec. A simple bi-layer low-e stack of

  10. Core-shell VO2@TiO2 nanorods that combine thermochromic and photocatalytic properties for application as energy-saving smart coatings

    PubMed Central

    Li, Yamei; Ji, Shidong; Gao, Yanfeng; Luo, Hongjie; Kanehira, Minoru

    2013-01-01

    Vanadium dioxide (VO2) is a Mott phase transition compound that can be applied as a thermochromic smart material for energy saving and comfort, and titanium dioxide (TiO2) is a well-known photocatalyst for self-cleaning coatings. In this paper, we report a VO2@TiO2 core-shell structure, in which the VO2 nanorod core exhibits a remarkable modulation ability for solar infrared light, and the TiO2 anatase shell exhibits significant photocatalytic degradation of organic dye. In addition, the TiO2 overcoating not only increased the luminous transmittance of VO2 based on an antireflection effect, but also modified the intrinsic colour of VO2 films from yellow to light blue. The TiO2 also enhanced the chemical stability of VO2 against oxidation. This is the first report of such a single nanoparticle structure with both thermochromic and photocatalytic properties that offer significant potential for creating a multifunctional smart coating. PMID:23546301

  11. Hepatoprotective effect of flavonol glycosides rich fraction from Egyptian Vicia calcarata Desf. against CCl4-induced liver damage in rats.

    PubMed

    Singab, Abdel Nasser B; Youssef, Diaa T A; Noaman, Eman; Kotb, Saeed

    2005-07-01

    The hepatoprotective activity of flavonol glycosides rich fraction (F-2), prepared from 70% alcohol extract of the aerial parts of V. calcarata Desf., was evaluated in a rat model with a liver injury induced by daily oral administration of CCl4 (100 mg/kg, b.w) for four weeks. Treatment of the animals with F-2 using a dose of (25 mg/kg, b.w) during the induction of hepatic damage by CCl4 significantly reduced the indices of liver injuries. The hepatoprotective effects of F-2 significantly reduced the elevated levels of the following serum enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). The antioxidant activity of F-2 markedly ameliorated the antioxidant parameters including glutathione (GSH) content, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), plasma catalase (CAT) and packed erythrocytes glucose-6-phosphate dehydrogenase (G6PDH) to be comparable with normal control levels. In addition, it normalized liver malondialdehyde (MDA) levels and creatinine concentration. Chromatographic purification of F-2 resulted in the isolation of two flavonol glycosides that rarely occur in the plant kingdom, identified as quercetin-3, 5-di-O-beta-D-diglucoside (5) and kaempferol-3, 5-di-O-beta-D-diglucoside (4) in addition to the three known compounds identified as quercetin-3-O-alpha-L-rhamnosyl- (1-->6)-beta-D-glucoside [rutin, 3], quercetin-3-O-beta-D-glucoside [isoquercitrin, 2] and kaempferol-3-O-beta-D-glucoside [astragalin, 1]. These compounds were identified based on interpretation of their physical, chemical, and spectral data. Moreover, the spectrophotometric estimation of the flavonoids content revealed that the aerial parts of the plant contain an appreciable amount of flavonoids (0.89%) calculated as rutin. The data obtained from this study revealed that the flavonol glycosides of F-2 protect the rat liver from hepatic damage induced by CCl4 through inhibition of

  12. INCREASING YIELDS AND BROADENING MARKETS: PROCESS INNOVATIONS IN THE MANUFACTURING OF ENERGY-SAVING WINDOW GLAZINGS

    SciTech Connect

    Mark Burdis; Neil Sbar

    2005-04-01

    The goal of this project was to develop and implement advanced thin film process technology which would significantly improve the manufacturability of both static and dynamic high performance energy saving coatings for windows. The work done has been aimed at improvements to the process that will result in increases in yield, and this was divided into four main areas, dealing with improvements in substrate preparation methods, reductions in the incidence of problems caused by particulate contamination, use of in-situ optical monitoring to improve process control, and overall system integration to enable simplified, and therefore lower cost operation. Significant progress has been made in each of the areas. In the area of substrate preparation, the enhanced washing techniques which have been developed, in combination with a new inspection technique, have resulted in significant reductions in the number of EC devices which are rejected because of substrate problems. Microscopic inspection of different defects in electrochromic devices showed that many were centered on particles. As a result, process improvements aimed at reducing the incidence of particles throughout the entire process have been implemented. As a result, the average number of defects occurring per unit area has been significantly reduced over the period of this project. The in-situ monitoring techniques developed during this project have become an indispensable part of the processing for EC devices. The deposition of several key layers is controlled as a result of in-situ monitoring, and this has facilitated significant improvements in uniformity and repeatability. Overall system integration has progressed to the stage where the goal of a closed-loop monitoring and control system in within reach, and it is anticipated that this will be achieved during the scale-up phase. There has been a clear increase in the yield occurring over the period of this project (Sept 1999 to September 2003), which is

  13. Measured energy savings and economics of retrofitting existing single-family homes: An update of the BECA-B database

    SciTech Connect

    Cohen, S.D.; Goldman, C.A.; Harris, J.P.

    1991-02-01

    The energy bill for US single-family households was over $77 billion in 1987 (excluding auto fuel purchases), accounting for approximately 20% of national energy expenditures. Large sums are spent on residential retrofits by individual homeowners, government agencies, and utilities. As of late 1987, over 21 million households indicated that they had added at least one energy-saving measure in the previous two years, while a recent Electric Power Research Institute (EPRI) study estimated that nearly 15 million residential customers have participated in some kind of demand-side management (DSM) program. Given the level of continuing investments in residential energy efficiency, accurate estimates of savings from various conservation measures are increasingly necessary, especially as new technologies become more sophisticated and incremental efficiency gains more difficult to achieve. This report provides a comparative analysis of measured data on the performance and cost-effectiveness of energy-saving measures in existing single-family homes, based on information in the Buildings Energy-Use Compilation and Analysis (BECA) data base. The initial BECA report on measured data for single-family retrofits was completed seven years ago. In updating the single-family database, we have added 135 data points, representing over 33,000 houses, to the original database of 145 retrofit projects. The report is organized in two volumes. Volume 1 provides a summary of energy savings and costs of individual retrofit measures and strategies and results from federal/state low-income and utility weatherization programs. we also discuss measurement issues, predicted versus actual savings, trends in single-family retrofit programs, and implications for the next generation'' of cost-effective single-family retrofits. Volume 2 contains a written summary of each retrofit project and complete data tables. 87 refs., 20 figs., 16 tabs.

  14. [Energy Consumption Comparison and Energy Saving Approaches for Different Wastewater Treatment Processes in a Large-scale Reclaimed Water Plant].

    PubMed

    Yang, Min; Li, Ya-ming; Wei, Yuan-song; Lü, Jian; Yu, Da-wei; Liu, Ji-bao; Fan, Yao-bo

    2015-06-01

    Energy consumption is the main performance indicator of reclaimed water plant (RWP) operation. Methods of specific energy consumption analysis, unit energy consumption analysis and redundancy analysis were applied to investigate the composition and spatio-temporal distribution of energy consumption in Qinghe RWP with inverted A2/O, A2/O and A2/O-MBR processes. And the A2/ O-MBR process was mainly analyzed to identify the main nodes and causes for high energy consumption, approaches for energy saving were explored, and the energy consumption before and after upgrading for energy saving was compared. The results showed that aeration was the key factor affecting energy consumption in both conventional and A2/O-MBR processes, accounting for 42.97% and 50.65% of total energy consumption, respectively. A pulsating aeration allowed an increasing membrane flux and remarkably reduced the energy consumption of the A2/O-MBR process while still meeting the effluent standard, e.g., the membrane flux was increased by 20%, and the energy consumptions per kiloton wastewater and kilogram COD(removed) were decreased by 42.39% to 0.53 kW-h-kg-3 and by 54.74% to 1.29 kW x h x kg(-1), respectively. The decrease of backflow ratio in the A2/O-MBR process within a certain range would not deteriorate the effluent quality due to its insignificant correlation with the effluent quality, and therefore may be considered as one of the ways for further energy saving. PMID:26387326

  15. Hepatoprotective Activity of Easter Lily (Lilium longiflorum Thunb.) Bulb Extracts.

    PubMed

    Tang, Wenping; Munafo, John P; Palatini, Kimberly; Esposito, Debora; Huang, Mou-Tuan; Komarnytsky, Slavko; Ho, Chi-Tang; Gianfagna, Thomas J

    2015-11-11

    The hepatoprotective activities of two different extracts, a hydroethanolic crude bulb extract (CB) and a steroidal glycoside-rich 1-butanol extract (BuOH), prepared from the bulbs of Easter lily (Lilium longiflorum Thunb.), were evaluated in a 24 week study in the female KK.Cg-A(y)/J Type 2 diabetic mouse model. Animals were divided into six groups (n = 16): control mice received Easter lily bulb extract-free drinking water together with a low- or high-fat diet (diabetic control); drinking water for the remaining groups was supplemented with CB extract (1%), BuOH extract (0.1 or 0.2%), and reference drug Metformin (0.001%), together with a high-fat diet. Both CB and BuOH extract treatment groups exhibited significantly improved liver function based on comparisons of triglycerides [diabetic 219 ± 34 mg/dL, CB 131 ± 27 mg/dL, BuOH(0.2%) 114 ± 35 mg/dL], CB total cholesterol (TC) (diabetic 196 ± 12 mg/dL, CB 159 ± 5 mg/dL), average liver mass [diabetic 2.96 ± 0.13 g, CB 2.58 ± 0.08 g, BuOH(0.1%) 2.48 ± 0.13 g], alanine transferase [diabetic 74 ± 5 units/L, CB 25 ± 1 units/L, BuOH(0.1%) 45 ± 1 units/L], and histological examinations. Glucose metabolism was improved only in CB, which was confirmed by oral glucose tolerance tests (OGTT) in diet-induced obese C57BL/6J mice exposed to CB extract. These data suggest that steroidal glycosides 1-5 might play a role in the hepatoprotective activity of the BuOH extracts, while the results of the TC measurements and OGTT study indicate that other constituents present in the CB extract are responsible for its hypocholesterolemic and hypoglycemic activity.

  16. Energy Savings Potential and Research, Development, & Demonstration Opportunities for Commercial Building Heating, Ventilation, and Air Conditioning Systems

    SciTech Connect

    none,

    2011-09-01

    This report covers an assessment of 182 different heating, ventilation, and air-conditioning (HVAC) technologies for U.S. commercial buildings to identify and provide analysis on 17 priority technology options in various stages of development. The analyses include an estimation of technical energy-savings potential, description of technical maturity, description of non-energy benefits, description of current barriers for market adoption, and description of the technology’s applicability to different building or HVAC equipment types. From these technology descriptions, are suggestions for potential research, development and demonstration (RD&D) initiatives that would support further development of the priority technology options.

  17. Energy Savings Potential and Research, Development, & Demonstration Opportunities for Residential Building Heating, Ventilation, and Air Conditioning Systems

    SciTech Connect

    Goetzler, William; Zogg, Robert; Young, Jim; Schmidt, Justin

    2012-10-01

    This report is an assessment of 135 different heating, ventilation, and air-conditioning (HVAC) technologies for U.S. residential buildings to identify and provide analysis on 19 priority technology options in various stages of development. The analyses include an estimation of technical energy-savings potential, descriptions of technical maturity, descriptions of non-energy benefits, descriptions of current barriers for market adoption, and descriptions of the technology's applicability to different building or HVAC equipment types. From these technology descriptions, are suggestions for potential research, development and demonstration (RD&D) initiatives that would support further development of the priority technology options.

  18. Energy Savings and Economics of Advanced Control Strategies for Packaged Air-Conditioning Units with Gas Heat

    SciTech Connect

    Wang, Weimin; Katipamula, Srinivas; Huang, Yunzhi; Brambley, Michael R.

    2011-12-31

    Pacific Northwest National Laboratory (PNNL) with funding from the U.S. Department of Energy's Building Technologies Program (BTP) evaluated a number of control strategies that can be implemented in a controller, to improve the operational efficiency of the packaged air conditioning units. The two primary objectives of this research project are: (1) determine the magnitude of energy savings achievable by retrofitting existing packaged air conditioning units with advanced control strategies not ordinarily used for packaged units and (2) estimating what the installed cost of a replacement control with the desired features should be in various regions of the U.S. This document reports results of the study.

  19. [Improving the solubility of fraxinellone to increase its oral bioavailability and hepatoprotective action against acute liver injury in mice].

    PubMed

    Ran, Qi-Qiong; Ruan, Li-Ping; Zhu, Dan-Ni; Yu, Bo-Yang

    2007-06-01

    Fraxinellone, the major component of Cortex Dictamni, is naturally degraded limonids compound. Fraxinellone has significant anti-inflammatory activity in acute liver injury model. However, the low solubility and permeability of fraxinellone limited its potential application and even therapeutic effects. The aim of the paper is to increase oral bioavailability of fraxinellone, thus improving its hepatoprotection effect in vivo. We evaluated the effects of different pH values and different solubilizer (PEG 6000, PVP K30, HP-beta-CD, F68 and SDS) on the solubility of fraxinellone. The results showed that HP-beta-CD increased solubility of fraxinellone up to 155 times compared to that of water. More than 2. 1 mg mL1 fraxinellone can be resolved when adding 20% HP-beta-CD. Mouse acute liver injury model induced hy CCl4 was used to evaluate in vivo activity of fraxinellone with or without HP-beta-CD. The result shows that the hepatoprotective activity of fraxinellone in 20% HP-beta-CD solution has been significantly improved compared with that of fraxinellone solution without HP-beta-CD: the former inhibited 59 percent the increase of enzyme activity of ALT in liver, while the latter only inhibited 20 percent. A LC-MS/MS method was also developed to determine the oral bioavailability of fraxinellone. Fraxinellone solution with or without HP-betaCD were administered intra-gastrically to rats, and it was found that the bioavailahility of fraxinellone with HP-beta-CD was 23%, while only 5% without HP-beta-CD. The result showed that HP-beta-CD can significantly increase the solubility and permeability of fraxinellone, and improve bioavailability 3. 5 fold in vivo acute liver injury model as well as administration.

  20. Streamlined energy-savings calculations for heat-island reduction strategies

    SciTech Connect

    Akbari, Hashem; Konopacki, Steven J.

    2003-03-15

    We have developed summary tables (sorted by heating- and cooling-degree-days) to estimate the potential of Heat-Island Reduction (HIR) strategies (i.e., solar-reflective roofs, shade trees, reflective pavements, and urban vegetation) to reduce cooling-energy use in buildings. The tables provide estimates of savings for both direct effect (reducing heat gain through the building shell) and indirect effect (reducing the ambient air temperature). In this analysis, we considered three building types that offer the most savings potential : residences, offices, and retail stores. Each building type was characterized in detail by Pre-1980 (old) or 1980+ (new) construction vintage and with natural gas or electricity as heating fuel. We defined prototypical-building characteristics for each building type and simulated the effects of HIR strategies on building cooling and heating energy use and peak power demand using the DOE-2.1E model and weather data for about 240 locations in the U.S. A statistical analysis of previously completed simulations for five cities was used to estimate the indirect savings. Our simulations included the effect of (1) solar-reflective roofing material on building [direct effect], (2) placement of deciduous shade trees near south and west walls of building [direct effect], and (3) ambient cooling achieved by urban reforestation and reflective building surfaces and pavements [indirect effect]. Upon completion of estimating the direct and indirect energy savings for all the selected locations, we integrated the results in tables arranged by heating- and cooling-degree-days. We considered 15 bins for heating-degree-days, and 11 bins for cooling-degree-days. Energy use and savings are presented per 1000 ft2 of roof area. In residences heated with gas and in climates with greater than 1000 cooling-degree-days, the annual electricity savings in Pre-1980 stock ranged from 650 to 1300 kWh/1000ft2; for 1980+ stock savings ranged 300 to 600 kWh/1000 ft2

  1. Dry Kraft Pulping at Ambient Pressure for Cost Effective Energy Saving and Pollution Deduction

    SciTech Connect

    Yulin Deng; Art Ragauskas

    2012-08-28

    evaporated first under vacuum condition at low temperature. Then, the dry woodchips were baked at high temperature (120-130 C) at atmospheric pressure. The qualities of the pulp made with this method were improved compared to that made with method one. The pulp shows higher brightness and lower bulk than Kraft pulping. The tensile strength is significantly higher than the pulp made from the first method. Although the pulp is stronger than that of TMP pulp, it is still lower than conventional Kraft fiber. Method Three: The third dry method was done in a Kraft pulping digester at elevated pressure but without free liquid in the digester. With this method, pulp that has almost the same qualities as conventional Kraft pulp could be produced. The screen yield, Kappa number, fiber brightness, pulp strength and pulp bulk are almost identical to the conventional Kraft pulp. The key advantages of this dry pulping method include ca. 55 % of cooking energy saved during the pulping process, as high as 50 wt% of NaOH saving as well as 3 wt% of Na2S saving comparing to Kraft one. By analyzing fiber properties, yields, chemical and energy consumptions, we concluded that the dry pulping method based on Liquid Free Chemical Pulping, LFCP, could be very attractive for the pulp and paper industry. More fundamental studies and scale up trials are needed to fully commercialize the technology. We expect to conduct pilot trials between 12 to 24 months of period if the DOE or industry can provide continual research funding. Based on the technology we demonstrated in this report, several pilot trial facilities in the United States will be available after small modifications. For example, the Herty Foundation in Savannah, Georgia is one of these potential locations. DOE funding for continuous study and final lead to commercialization of the technique is important.

  2. Guidebook for Using the Tool BEST Cement: Benchmarking and Energy Savings Tool for the Cement Industry

    SciTech Connect

    Galitsky, Christina; Price, Lynn; Zhou, Nan; Fuqiu , Zhou; Huawen, Xiong; Xuemin, Zeng; Lan, Wang

    2008-07-30

    The Benchmarking and Energy Savings Tool (BEST) Cement is a process-based tool based on commercially available efficiency technologies used anywhere in the world applicable to the cement industry. This version has been designed for use in China. No actual cement facility with every single efficiency measure included in the benchmark will likely exist; however, the benchmark sets a reasonable standard by which to compare for plants striving to be the best. The energy consumption of the benchmark facility differs due to differences in processing at a given cement facility. The tool accounts for most of these variables and allows the user to adapt the model to operational variables specific for his/her cement facility. Figure 1 shows the boundaries included in a plant modeled by BEST Cement. In order to model the benchmark, i.e., the most energy efficient cement facility, so that it represents a facility similar to the user's cement facility, the user is first required to input production variables in the input sheet (see Section 6 for more information on how to input variables). These variables allow the tool to estimate a benchmark facility that is similar to the user's cement plant, giving a better picture of the potential for that particular facility, rather than benchmarking against a generic one. The input variables required include the following: (1) the amount of raw materials used in tonnes per year (limestone, gypsum, clay minerals, iron ore, blast furnace slag, fly ash, slag from other industries, natural pozzolans, limestone powder (used post-clinker stage), municipal wastes and others); the amount of raw materials that are preblended (prehomogenized and proportioned) and crushed (in tonnes per year); (2) the amount of additives that are dried and ground (in tonnes per year); (3) the production of clinker (in tonnes per year) from each kiln by kiln type; (4) the amount of raw materials, coal and clinker that is ground by mill type (in tonnes per year); (5

  3. Energy Saving Melting and Revert Reduction (E-SMARRT): Precision Casting of Steel

    SciTech Connect

    Dr. Von L. Richards

    2011-09-30

    of the casting opposite the gate. (3) It is recommended that lost foam castings in steel be gated for a quiescent fill in an empty cavity mold to prevent foam occlusion defects from the collapse mode. The energy benefit is primarily in yield savings and lower casting weight per function due to elimination of draft and parting lines for the larger lost foam castings. For the smaller investment casting, scrap losses due to shell cracking will be reduced. Both of these effects will reduce the metal melted per good ton of castings. There will also be less machine stock required per casting which is a yield savings and a small additional energy savings in machining. Downstream savings will come from heavy truck and railroad applications. Application of these processes to heavy truck castings will lighten the heavy truck fleet by about ten pounds per truck. Using ten years to achieve full penetration of the truck fleet at linear rate this will result in a fuel savings of 131 trillion BTU over ten years.

  4. Hepatoprotective activity of Moringa oleifera against cadmium toxicity in rats

    PubMed Central

    Toppo, Reetu; Roy, Birendra Kumar; Gora, Ravuri Halley; Baxla, Sushma Lalita; Kumar, Prabhat

    2015-01-01

    Aim: The present investigation has been conducted to evaluate the hepatoprotective activity of Moringa oleifera against cadmium-induced toxicity in rats. Materials and Methods: For this study, 18 Wistar albino rats were taken. Control group, Group I rats were given cadmium chloride @ 200 ppm per kg and Group II rats were treated with M. oleifera extract @ 500 mg/kg along with cadmium chloride @ 200 ppm per kg (daily oral for 28 days). On 29th day, animals were slaughtered and various parameters were determined. Serum biomarkers, oxidative stress parameters, histomorphological examination were carried out with estimation of cadmium concentration in liver tissues. Results: Oral administration of cadmium chloride @ 200 ppm/kg for 28 days resulted in a significant increase in aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), significant (p≤0.01) increase of lipid peroxidation (LPO) and decrease in superoxide dismutase (SOD), and increase in cadmium accumulation in liver. Treatment with M. oleifera @ 500 mg/kg significantly (p<0.01) decreased the elevated ALP, AST, ALT, LPO levels and increase in SOD levels, and as compared to cadmium chloride treated group. However, there was no significant difference in cadmium concentration in liver when compared with cadmium chloride treated group. Conclusion: The study conclude that supplementation of M. oleifera (500 mg/kg), daily oral for 28 days has shown protection against cadmium-induced hepatotoxicity. PMID:27047130

  5. Development and Evaluation of Hepatoprotective Polyherbal Formulation Containing Some Indigenous Medicinal Plants

    PubMed Central

    Dandagi, P. M.; Patil, M. B.; Mastiholimath, V. S.; Gadad, A. P.; Dhumansure, R. H.

    2008-01-01

    The present study explores the hepatoprotective activity of various extracts of Ferula asafoetida, Momordica charantia Linn and Nardostachys jatamansi against experimental hepatotoxicity. Polyherbal suspensions were formulated using extracts showing significant activity and evaluated for both physicochemical and hepatoprotective activity in comparison with LIV-52 as standard. Petroleum ether (60-80°), chloroform, benzene, ethanol and aqueous extracts of Ferula asafetida, Momordica charantia Linn and Nardostachys jatamansi were evaluated for hepatoprotective activity against carbon tetrachloride-induced liver toxicity in Wistar rats. Polyherbal suspensions were prepared by the trituration method using a suspending agent and other excipients. Formulation F3 has shown significant hepatoprotective effect by reducing the elevated serum enzyme levels such as glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and alkaline phosphatase. These biochemical observations were supplemented by histopathological examination of liver sections. Various parameters evaluated for all formulations were within the official specifications. Experimental data suggested that treatment with formulation F3 enhances the recovery from carbon tetra chloride-induced hepatotoxicity. From these results it may be concluded that the F3 formulation (containing chloroform, petroleum ether and aqueous extracts of Ferula asafetida, petroleum ether and ethanol extracts of Momordica charantia Linn. and petroleum ether and ethanol extracts of Nardostachys jatamansi) demonstrated significant hepatoprotective activity, that might be due to combined effect of all these extracts. PMID:20046731

  6. A heuristic placement selection of live virtual machine migration for energy-saving in cloud computing environment.

    PubMed

    Zhao, Jia; Hu, Liang; Ding, Yan; Xu, Gaochao; Hu, Ming

    2014-01-01

    The field of live VM (virtual machine) migration has been a hotspot problem in green cloud computing. Live VM migration problem is divided into two research aspects: live VM migration mechanism and live VM migration policy. In the meanwhile, with the development of energy-aware computing, we have focused on the VM placement selection of live migration, namely live VM migration policy for energy saving. In this paper, a novel heuristic approach PS-ES is presented. Its main idea includes two parts. One is that it combines the PSO (particle swarm optimization) idea with the SA (simulated annealing) idea to achieve an improved PSO-based approach with the better global search's ability. The other one is that it uses the Probability Theory and Mathematical Statistics and once again utilizes the SA idea to deal with the data obtained from the improved PSO-based process to get the final solution. And thus the whole approach achieves a long-term optimization for energy saving as it has considered not only the optimization of the current problem scenario but also that of the future problem. The experimental results demonstrate that PS-ES evidently reduces the total incremental energy consumption and better protects the performance of VM running and migrating compared with randomly migrating and optimally migrating. As a result, the proposed PS-ES approach has capabilities to make the result of live VM migration events more high-effective and valuable. PMID:25251339

  7. Efficiency of Energy Use in the United States: Transportation, space heating, and air conditioning provide opportunities for large energy savings.

    PubMed

    Hirst, E; Moyers, J C

    1973-03-30

    We described three uses of energy for which greater efficiency is feasible: transportation, space heating, and air conditioning. Shifts to less energy-intensive transportation modes could substantially reduce energy consumption; the magnitude of such savings would, of course, depend on the extent of such shifts and possible load factor changes. The hypothetical transportation scenario described here results in a 22 percent savings in energy for transportation in 1970, a savings of 2800 trillion Btu. To the homeowner, increasing the amount of building insulation and, in some cases, adding storm windows would reduce energy consumption and provide monetary savings. If all homes in 1970 had the "economic optimum" amount of insulation, energy consumption for residential heating would have been 42 percent less than if the homes were insulated to meet the pre-1971 FHA standards, a savings of 3100 trillion Btu. Increased utilization of energy-efficient air conditioners and of building insulation would provide significant energy savings and help to reduce peak power demands during the summer. A 67 percent increase in energy efficiency for room air conditioners would have saved 15.8 billion kilowatt-hours in 1970. In conclusion, it is possible-from an engineering point of view-to effect considerable energy savings in the United States. Increases in the efficiency of energy use would provide desired end results with smaller energy inputs. Such measures will not reduce the level of energy consumption, but they could slow energy growth rates.

  8. A heuristic placement selection of live virtual machine migration for energy-saving in cloud computing environment.

    PubMed

    Zhao, Jia; Hu, Liang; Ding, Yan; Xu, Gaochao; Hu, Ming

    2014-01-01

    The field of live VM (virtual machine) migration has been a hotspot problem in green cloud computing. Live VM migration problem is divided into two research aspects: live VM migration mechanism and live VM migration policy. In the meanwhile, with the development of energy-aware computing, we have focused on the VM placement selection of live migration, namely live VM migration policy for energy saving. In this paper, a novel heuristic approach PS-ES is presented. Its main idea includes two parts. One is that it combines the PSO (particle swarm optimization) idea with the SA (simulated annealing) idea to achieve an improved PSO-based approach with the better global search's ability. The other one is that it uses the Probability Theory and Mathematical Statistics and once again utilizes the SA idea to deal with the data obtained from the improved PSO-based process to get the final solution. And thus the whole approach achieves a long-term optimization for energy saving as it has considered not only the optimization of the current problem scenario but also that of the future problem. The experimental results demonstrate that PS-ES evidently reduces the total incremental energy consumption and better protects the performance of VM running and migrating compared with randomly migrating and optimally migrating. As a result, the proposed PS-ES approach has capabilities to make the result of live VM migration events more high-effective and valuable.

  9. Energy Saving and GHG Emission Reduction in a Micro-CCHP System by Use of Solar Energy

    NASA Astrophysics Data System (ADS)

    Ion, Ion V.; Ciocea, Gheorghe; Popescu, Florin

    2012-12-01

    In this work, the reduction of greenhouse gas emission, and the energy saving by integrating solar collectors and photovoltaic panels in a Stirling engine based microcombined cooling, heating and power (mCCHP) system are studied. The mCCHP system consists of a natural gas Stirling CHP and an adsorber chiller. When the thermal outputs of the Stirling CHP and solar collectors are not sufficient to cover the heat demand for domestic hot water (DHW), heating/cooling, an auxiliary heating boiler starts to operate. The energy saving by using solar energy varies from 13.35% in December to 59.62% in April, in the case of solar collectors usage and from 7.47% in December to 28.27% in July, in the case of photovoltaic panels usage. By using solar energy the annual GHG emission decreases by 31.98% and the fuel cost reduction varies from 12.73% in December to 49.78% in June.

  10. A Heuristic Placement Selection of Live Virtual Machine Migration for Energy-Saving in Cloud Computing Environment

    PubMed Central

    Zhao, Jia; Hu, Liang; Ding, Yan; Xu, Gaochao; Hu, Ming

    2014-01-01

    The field of live VM (virtual machine) migration has been a hotspot problem in green cloud computing. Live VM migration problem is divided into two research aspects: live VM migration mechanism and live VM migration policy. In the meanwhile, with the development of energy-aware computing, we have focused on the VM placement selection of live migration, namely live VM migration policy for energy saving. In this paper, a novel heuristic approach PS-ES is presented. Its main idea includes two parts. One is that it combines the PSO (particle swarm optimization) idea with the SA (simulated annealing) idea to achieve an improved PSO-based approach with the better global search's ability. The other one is that it uses the Probability Theory and Mathematical Statistics and once again utilizes the SA idea to deal with the data obtained from the improved PSO-based process to get the final solution. And thus the whole approach achieves a long-term optimization for energy saving as it has considered not only the optimization of the current problem scenario but also that of the future problem. The experimental results demonstrate that PS-ES evidently reduces the total incremental energy consumption and better protects the performance of VM running and migrating compared with randomly migrating and optimally migrating. As a result, the proposed PS-ES approach has capabilities to make the result of live VM migration events more high-effective and valuable. PMID:25251339

  11. Differential CO{sub 2} based demand control ventilation (maximum energy savings and optimized IAQ): History, theory and myths

    SciTech Connect

    Di Giacomo, S.M.

    1999-10-01

    Demand control ventilation (DCV) utilizing continuous outdoor and indoor (differential) carbon dioxide (CO{sub 2}) measurements is an elegant closed loop feedback control methodology for determining damper position in a continuously changing HVAC system environment and subsequently maintaining a constant steady-state ventilation air (CFM) per person level. This article deals directly with the numerous misconceptions surrounding this technology as well as its applications as an energy conservation measure and commissioning tool. Summarized below are some of the benefits of adopting the DCV technology utilizing differential CO{sub 2} measurements. DCV, when used as an HVAC VAV or CV mix air return system energy savings retrofit tool, can save energy when it functions in conjunction with existing (base case) energy savings control methodologies. This means that DCV control algorithms must be suspended, through computer programming, whenever normal free cooling opportunities exist--otherwise, energy consumption will increase. For example: If free cooling economizer controls exist in the base case, then the engineer must ensure that they continue to exist in the retrofit case.

  12. The Analysis on Influence of Main Factors on Theoretical Value of Energy Saving Rate for Energy Efficiency Labeling of Civil Buildings

    NASA Astrophysics Data System (ADS)

    Wang, Zhiwei; Wang, Zhenling; Jiang, Bo; Zhang, Fan; Li, Peng; Cao, Wei

    For typical residential buildings, no-large-scale and large-scale public buildings, according to China's Technical Guide for the Energy Efficiency Labeling of Civil Buildings, makes up missing data of the calculation benchmark and determines the boundary conditions for calculating the theoretical values of civil building energy efficiency. Based on equivalent full load hours method, develops a modular program and calculates building energy consumption for the demands of dynamic cooling and heating and lighting etc., finds out the corresponding relationship between star level's theoretical value of energy saving rate and specified-term limiting value in the Guide. With orthogonal experimental design and multiple linear regression, establishes the quantitative function of both the theoretical value of energy saving rate and main factors parameters, analyzes the impact of the control parameter on energy saving rate, and reveals the law of theoretical value of energy saving rate variation with the control parameter. For building energy efficiency labeling upgrade, presents technical measure need to be taken and analyses its feasibility. The results from the study can provide theoretical guidance for energy-saving design or retrofitting of civil buildings.

  13. Improved Hepatoprotective Effect of Liposome-Encapsulated Astaxanthin in Lipopolysaccharide-Induced Acute Hepatotoxicity

    PubMed Central

    Chiu, Chun-Hung; Chang, Chun-Chao; Lin, Shiang-Ting; Chyau, Charng-Cherng; Peng, Robert Y.

    2016-01-01

    Lipopolysaccharide (LPS)-induced acute hepatotoxicity is significantly associated with oxidative stress. Astaxanthin (AST), a xanthophyll carotenoid, is well known for its potent antioxidant capacity. However, its drawbacks of poor aqueous solubility and low bioavailability have limited its utility. Liposome encapsulation is considered as an effective alternative use for the improvement of bioavailability of the hydrophobic compound. We hypothesized that AST encapsulated within liposomes (LA) apparently shows improved stability and transportability compared to that of free AST. To investigate whether LA administration can efficiently prevent the LPS-induced acute hepatotoxicity, male Sprague-Dawley rats (n = six per group) were orally administered liposome-encapsulated AST at 2, 5 or 10 mg/kg-day (LA-2, LA-5, and LA-10) for seven days and then were LPS-challenged (i.p., 5 mg/kg). The LA-10 administered group, but not the other groups, exhibited a significant amelioration of serum glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), blood urea nitrogen (BUN), creatinine (CRE), hepatic malondialdehyde (MDA) and glutathione peroxidase (GSH-Px), IL-6, and hepatic nuclear NF-κB and inducible nitric oxide synthase (iNOS), suggesting that LA at a 10 mg/kg-day dosage renders hepatoprotective effects. Moreover, the protective effects were even superior to that of positive control N-acetylcysteine (NAC, 200 mg/kg-day). Histopathologically, NAC, free AST, LA-2 and LA-5 partially, but LA-10 completely, alleviated the acute inflammatory status. These results indicate that hydrophobic AST after being properly encapsulated by liposomes improves bioavailability and can also function as potential drug delivery system in treating hepatotoxicity. PMID:27428953

  14. Hepatoprotective potential of Aloe barbadensis Mill. against carbon tetrachloride induced hepatotoxicity.

    PubMed

    Chandan, B K; Saxena, A K; Shukla, Sangeeta; Sharma, Neelam; Gupta, D K; Suri, K A; Suri, Jyotsna; Bhadauria, M; Singh, B

    2007-05-22

    Aloe barbadensis Mill. Syn. Aloe vera Tourn. ex Linn.(Liliaceae) has been used in variety of diseases in traditional Indian system of medicine in India and its use for hepatic ailments is also documented. In the present study an attempt has been made to validate its hepatoprotective activity. The shade dried aerial parts of Aloe barbadensis were extracted with petroleum ether (AB-1), chloroform (AB-2) and methanol (AB-3). The plant marc was extracted with distilled water (AB-4). All the extracts were evaluated for hepatoprotective activity on limited test models as hexobarbitone sleep time, zoxazolamine paralysis time and marker biochemical parameters. AB-1 and AB-2 were observed to be devoid of any hepatoprotective activity. Out of two active extracts (AB-3 and AB-4), the most active AB-4 was studied in detail. AB-4 showed significant hepatoprotective activity against CCl4 induced hepatotoxicity as evident by restoration of serum transaminases, alkaline phosphatase, bilirubin and triglycerides. Hepatoprotective potential was confirmed by the restoration of lipid peroxidation, glutathione, glucose-6-phosphatase and microsomal aniline hydroxylase and amidopyrine N-demethylase towards near normal. Histopathology of the liver tissue further supports the biochemical findings confirming the hepatoprotective potential of AB-4. The present study shows that the aqueous extract of Aloe barbadensis is significantly capable of restoring integrity of hepatocytes indicated by improvement in physiological parameters, excretory capacity (BSP retention) of hepatocytes and also by stimulation of bile flow secretion. AB-4 did not show any sign of toxicity up to oral dose of 2 g/kg in mice.

  15. A sexual dimorphism influences bicyclol-induced hepatic heat shock factor 1 activation and hepatoprotection.

    PubMed

    Chen, Xiaosong; Zhang, Jianjian; Han, Conghui; Dai, Huijuan; Kong, Xianming; Xu, Longmei; Xia, Qiang; Zhang, Ming; Zhang, Jianjun

    2015-07-01

    Bicyclol [4,4'-dimethoxy-5,6,5',6'-bis(methylenedioxy)-2-hydroxy-methyl-2'-methoxycarbonyl biphenyl] is a synthetic hepatoprotectant widely used in clinical practice, but resistance to this treatment is often observed. We found that the hepatoprotective effect of bicyclol was greatly compromised in female and castrated male mice. This study was to dissect the molecular basis behind the sex difference, which might underlie the clinical uncertainty. We compared bicyclol-induced hepatoprotection between male and female mice using acute liver damage models. Inducible knockout by the Cre/loxp system was used to decipher the role of heat shock transcription factor 1 (HSF1). Functional experiments, western blot, and histopathological analysis were used to determine the key causative factors which might antagonize bicyclol in female livers. HSF1 activation and heat shock protein 70 (Hsp70) expression, which were responsible for bicyclol-induced hepatoprotection, were compromised in female and castrated male livers. Compromised HSF1 activation was a result of HSF1 phosphorylation at serine 303, which was catalyzed by glycogen synthase kinase 3β (GSK3β). Testosterone was necessary for bicyclol to inhibit hepatic GSK3β activity. Administration of testosterone or GSK3β inhibitors restored bicyclol-induced protection in females. Bicyclol induces sex-specific hepatoprotection based on a sex-specific HSF1/Hsp70 response, in which testosterone and GSK3β play key roles. Because a lot of patients suffering from liver diseases have very low testosterone levels, our results give a possible explanation for the clinical variation in bicyclol-induced hepatoprotection, as well as practicable solutions to improve the effect of bicyclol. PMID:25901028

  16. Preliminary evaluation of hepatoprotective potential of the polyherbal formulation

    PubMed Central

    Arka, Ghosh; Anindita, Kundu; Ankit, Seth; Kumar, Singh Anil; Kumar, Maurya Santosh

    2015-01-01

    Aim: The aim of this study was to investigate the antioxidant and hepatoprotective effects of the polyherbal formulation (PHF)containing Cajanus cajan (L.)Millsp., Lawsonia inermis L. Linn, Mimosa pudica L., Uraria picta (Jacq.)DC. and Operculina turpethum (L.)Silva Manso on carbon tetrachloride (CCl4)induced acute liver damage in albino rats. Materials and Methods: The groups of animals were administered with PHF at the doses 100, 200 and 400 mg/kg b.w. (per oral [p.o.])once in a day for 7 days and at day 6th and 7th the animals were administrated with Carbon tetrachloride (1.0 mL/kg b.w. 50% v/v with olive oil,; p.o.). The effect of PHF on serum glutamine pyruvate transaminase (SGPT), serum glutamine oxaloacetate transaminase, alkaline phosphatase (ALP)and total bilirubin were determined in CCl4 - induced hepatotoxicity in rats. Further, the effects of PHF on glutathione (GSH), superoxide dismutase (SOD)level and lipid peroxidation (LPO)activity were also investigated. Results: The results demonstrated that PHF (400 mg/kg b.w.)significantly reduces the CCl4 induced increase in level of serum SGPT, serum ALP and total bilirubin. PHF (400 mg/kg b.w.)prevents the depletion level of GSH and decrease in the activity of SOD in CCl4 -induced liver injury in rats. In addition, PHF also showed a significant decrease in the LPO levels signifying the potent antioxidant activity. Conclusion: All our findings suggest that PHF could protect the liver cells from CCl4 - induced liver damages and the mechanism may be through the anti-oxidative effect of PHF. PMID:26401397

  17. Antioxidant and hepatoprotective effects of Crataegus songarica methanol extract.

    PubMed

    Ganie, Showkat Ahmad; Dar, Tanveer Ali; Zargar, Bilal; Hamid, Rabia; Zargar, Ovais; Dar, Parvaiz Ahmad; Abeer, Shayaq Ul; Masood, Akbar; Amin, Shajrul; Zargar, Mohammad Afzal

    2014-01-01

    The protective activity of the methanolic extract of the Crataegus songarica leaves was investigated against CCl4- and paracetamol-induced liver damage. On folklore levels, this plant is popularly used to treat various toxicological diseases. We evaluated both in vitro and ex vivo antioxidant activity of C. songarica. At higher concentration of plant extract (700 µg/ml), 88.106% inhibition on DPPH radical scavenging activity was observed and reducing power of extract was increased in a concentration-dependent manner. We also observed its inhibition on Fe2+/ascorbic acid-induced lipid peroxidation on rat liver microsomes in vitro. In addition, C. songarica extract exhibited antioxidant effects on calf thymus DNA damage induced by Fenton reaction. Hepatotoxicity was induced by challenging the animals with CCl4 (1 ml/kg body weight, i.p.) and paracetamol (500 mg/kg body weight) and the extract was administered at three concentrations (100, 200, and 300 mg/kg body weight). Hepatoprotection was evaluated by determining the activities of liver function marker enzymes and antioxidant status of liver. Administration of CCl4 elevated the levels of liver function enzymes, SGOT, SGPT, and LDH. We also observed a dramatic increase in ALT, AST, bilirubin, and alkaline phosphatase levels in rats administered 500 mg/kg body weight of paracetamol. Decreased antioxidant defense system as glutathione (GSH), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), glutathione-S-transferase (GST), and superoxide dismutase (SOD) were observed in rats treated with CCl4 and paracetamol. Pretreatment with the extract decreased the elevated serum GOT, GPT, LDH, bilirubin, and alkaline phosphatase activities and increased the antioxidant enzymes in a dose-dependent manner. Therefore, C. songarica methanol extract may be an effective hepatic protective agent and viable candidate for treating hepatic disorders and other oxidative stress-related diseases. PMID:24941296

  18. Chemical composition, antioxidant properties and hepatoprotective effects of chamomile (Matricaria recutita L.) decoction extract against alcohol-induced oxidative stress in rat.

    PubMed

    Sebai, Hichem; Jabri, Mohamed-Amine; Souli, Abdelaziz; Hosni, Karim; Rtibi, Kais; Tebourbi, Olfa; El-Benna, Jamel; Sakly, Mohsen

    2015-07-01

    The present study assessed the chemical composition, antioxidant properties, and hepatoprotective effects of subacute pre-treatment with chamomile (Matricaria recutita L.) decoction extract (CDE) against ethanol (EtOH)-induced oxidative stress in rats. The colorimetric analysis demonstrated that the CDE is rich in total polyphenols, total flavonoids and condensed tannins, and exhibited an important in vitro antioxidant activity. The use of LC/MS technique allowed us to identify 10 phenolic compounds in CDE. We found that CDE pretreatment, in vivo, protected against EtOH-induced liver injury evident by plasma transaminases activity and preservation of the hepatic tissue structure. The CDE counteracted EtOH-induced liver lipoperoxidation, preserved thiol -SH groups and prevented the depletion of antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). We also showed that acute alcohol administration increased tissue and plasma hydrogen peroxide (H(2)O(2)), calcium and free iron levels. More importantly, CDE pre-treatment reversed all EtOH-induced disturbances in intracellular mediators. In conclusion, our data suggest that CDE exerted a potential hepatoprotective effect against EtOH-induced oxidative stress in rat, at least in part, by negatively regulating Fenton reaction components such as H(2)O(2) and free iron, which are known to lead to cytotoxicity mediated by intracellular calcium deregulation. PMID:25816359

  19. Energy saving for OpenFlow switch on the NetFPGA platform based on queue engineering.

    PubMed

    Vu, Tran Hoang; Luc, Vu Cong; Quan, Nguyen Trung; Thanh, Nguyen Huu; Nam, Pham Ngoc

    2015-01-01

    Data centers play an important role in our daily activities. The increasing demand on data centers in both scale and size has led to huge energy consumption that rises the cost of data centers. Besides, environmental impacts also increase considerably due to a large amount of carbon emissions. In this paper, we present a design aimed at green networking by reducing the power consumption for routers and switches. Firstly, we design the Balance Switch on the NetFPGA platform to save consumed energy based on Queue Engineering. Secondly, we design the test-bed system to precisely measure the consumed energy of our switches. Experimental results show that energy saving of our switches is about 30% - 35% of power consumption according to variation of input traffic compared with normal Openflow Switch. Finally, we describe performance evaluations.

  20. Energy Saving Melting and Revert Reduction Technology: Improved Die Casting Process to Preserve the Life of the Inserts

    SciTech Connect

    David Schwam, PI; Xuejun Zhu, Sr. Research Associate

    2012-09-30

    lubricants and technical support. Experiments conducted with these lubricants demonstrated good protection of the substrate steel. Graphite and boron nitride used as benchmarks are capable of completely eliminating soldering and washout. However, because of cost and environmental considerations these materials are not widely used in industry. The best water-based die lubricants evaluated in this program were capable of providing similar protection from soldering and washout. In addition to improved part quality and higher production rates, improving die casting processes to preserve the life of the inserts will result in energy savings and a reduction in environmental wastes. Improving die life by means of optimized cooling line placement, baffles and bubblers in the die will allow for reduced die temperatures during processing, saving energy associated with production. The utilization of optimized die lubricants will also reduce heat requirements in addition to reducing waste associated with soldering and washout. This new technology was predicted to result in an average energy savings of 1.1 trillion BTU's/year over a 10 year period. Current (2012) annual energy saving estimates, based on commercial introduction in 2010, a market penetration of 70% by 2020 is 1.26 trillion BTU's/year. Along with these energy savings, reduction of scrap and improvement in casting yield will result in a reduction of the environmental emissions associated with the melting and pouring of the metal which will be saved as a result of this technology. The average annual estimate of CO2 reduction per year through 2020 is 0.025 Million Metric Tons of Carbon Equivalent (MM TCE).

  1. Technical Support Document: Development of the Advanced Energy Design Guide for Medium Box Retail -- 50% Energy Savings

    SciTech Connect

    Hale, E. T.; Macumber, D. L.; Long, N. L.; Griffith, B. T.; Benne, K. S.; Pless, S. D.; Torcellini, P. A.

    2008-09-01

    This report provides recommendations that architects, designers, contractors, developers, owners, and lessees of medium box retail buildings can use to achieve whole-building energy savings of at least 50% over ASHRAE Standard 90.1-2004. The recommendations are given by climate zone and address building envelope, fenestration, lighting systems, HVAC systems, building automation and controls, outside air treatment, service water heating, plug loads, and photovoltaic systems. The report presents several paths to 50% savings, which correspond to different levels of integrated design. These are recommendations only, and are not part of a code or standard. The recommendations are not exhaustive, but we do try to emphasize the benefits of integrated building design, that is, a design approach that analyzes a building as a whole system, rather than as a disconnected collection of individually engineered subsystems.

  2. New Whole-House Solutions Case Study: Low-Cost Evaluation of Energy Savings at the Community Scale - Fresno, California

    SciTech Connect

    2014-10-01

    In this project, IBACOS partnered with builder Wathen-Castanos Hybrid Homes to develop a simple and low-cost methodology by which community-scale energy savings can be evaluated based on results at the occupied test house level.Research focused on the builder and trade implementation of a whole-house systems integrated measures package and the actual utility usage in the houses at the community scale of production. Five occupants participated in this community-scale research by providing utility bills and information on occupancy and miscellaneous gas and electric appliance use for their houses. IBACOS used these utility data and background information to analyze the actual energy performance of the houses. Verification with measured data is an important component in predictive energy modeling. The actual utility bill readings were compared to projected energy consumption using BEopt with actual weather and thermostat set points for normalization.

  3. Recycling of steel slag and glass cullet from energy saving lamps by fast firing production of ceramics.

    PubMed

    Furlani, E; Tonello, G; Maschio, S

    2010-01-01

    The paper reports on some experimental results obtained from the production of ceramics containing steel slag and glass cullet from exhaust energy saving lamps mixed in different proportions. Blending of components was done by attrition milling. Pressed powders were fast fired (50 min, cold to cold) in air up to several temperatures in the range 1000-1140 degrees C. The sintering behaviour was studied by shrinkage and water absorption measurements. Density, strength and hardness of the fired bodies were determined and XRD were examined. The fired samples were finally tested in acidic environment in order to evaluate their elution behaviour and consequently their possible environmental compatibility. It is observed that the composition containing 60 wt.% of steel slag and 40 wt.% of glass cullet displayed the best overall behaviour.

  4. Building America Best Practices Series Volume 16: 40% Whole-House Energy Savings in the Mixed-Humid Climate

    SciTech Connect

    Baechler, Michael C.; Gilbride, Theresa L.; Hefty, Marye G.; Cole, Pamala C.; Adams, Karen; Butner, Ryan S.; Ortiz, Sallie J.

    2011-09-01

    This best practices guide is the 16th in a series of guides for builders produced by PNNL for the U.S. Department of Energy’s Building America program. This guide book is a resource to help builders design and construct homes that are among the most energy-efficient available, while addressing issues such as building durability, indoor air quality, and occupant health, safety, and comfort. With the measures described in this guide, builders in the mixed-humid climate can build homes that have whole-house energy savings of 40% over the Building America benchmark with no added overall costs for consumers. The best practices described in this document are based on the results of research and demonstration projects conducted by Building America’s research teams. Building America brings together the nation’s leading building scientists with over 300 production builders to develop, test, and apply innovative, energy-efficient construction practices. Building America builders have found they can build homes that meet these aggressive energy-efficiency goals at no net increased costs to the homeowners. Currently, Building America homes achieve energy savings of 40% greater than the Building America benchmark home (a home built to mid-1990s building practices roughly equivalent to the 1993 Model Energy Code). The recommendations in this document meet or exceed the requirements of the 2009 IECC and 2009 IRC and those requirements are highlighted in the text. Requirements of the 2012 IECC and 2012 IRC are also noted in text and tables throughout the guide. This document will be distributed via the DOE Building America website: www.buildingamerica.gov.

  5. Building America Best Practices Series Volume 15: 40% Whole-House Energy Savings in the Hot-Humid Climate

    SciTech Connect

    Baechler, Michael C.; Gilbride, Theresa L.; Hefty, Marye G.; Cole, Pamala C.; Adams, Karen; Noonan, Christine F.

    2011-09-01

    This best practices guide is the 15th in a series of guides for builders produced by PNNL for the U.S. Department of Energy’s Building America program. This guide book is a resource to help builders design and construct homes that are among the most energy-efficient available, while addressing issues such as building durability, indoor air quality, and occupant health, safety, and comfort. With the measures described in this guide, builders in the hot-humid climate can build homes that have whole-house energy savings of 40% over the Building America benchmark with no added overall costs for consumers. The best practices described in this document are based on the results of research and demonstration projects conducted by Building America’s research teams. Building America brings together the nation’s leading building scientists with over 300 production builders to develop, test, and apply innovative, energy-efficient construction practices. Building America builders have found they can build homes that meet these aggressive energy-efficiency goals at no net increased costs to the homeowners. Currently, Building America homes achieve energy savings of 40% greater than the Building America benchmark home (a home built to mid-1990s building practices roughly equivalent to the 1993 Model Energy Code). The recommendations in this document meet or exceed the requirements of the 2009 IECC and 2009 IRC and those requirements are highlighted in the text. Requirements of the 2012 IECC and 2012 IRC are also noted in text and tables throughout the guide. This document will be distributed via the DOE Building America website: www.buildingamerica.gov.

  6. A New Type of Liquid Silymarin Proliposome Containing Bile Salts: Its Preparation and Improved Hepatoprotective Effects

    PubMed Central

    Chang, Zhanying; Wang, Ling; Xie, Xiangyun; Kou, Yaohong; Xu, Hongxia; Gao, Xiaoli

    2015-01-01

    Silymarin, a known extract, is used in the treatment of liver diseases with various origins, but its current administration form cannot target the liver because of its poor oral bioavailability. A new type of oral silymarin proliposome aimed at improving silymarin’s poor bioavailability and hepatoprotective effects, is introduced in this work. Silymarin-loaded liquid proliposome were prepared using a simple dissolving process. The morphology, particle size, zeta potential, and entrapment efficiency of the silymarin liposomes were analysed. The everted gut sac transport model was used to measure the intestinal transport of liposomes. The liposomal hepatoprotective activity was evaluated in three types of experimental hepatitis animal models. After staining with haematoxylin and eosin, the livers were microscopically examined to analyse any pathological changes. The prepared silymarin proliposome formed silymarin liposomes with a multilayer liposome structure and improved intestinal transport. In an injured liver, the silymarin liposomes produced a stronger hepatoprotective effect through a significant decrease in both the aminotransferase and MDA levels and a significant increase in the SOD and GSH-PX levels compared to orally administered silymarin tablets. This effect was also confirmed histopathologically. In a word, incorporation of silymarin into a liposomal carrier system increased intestinal absorption and showed better hepatoprotective effects compared to silymarin tablets. PMID:26674103

  7. Hepatoprotective activity of Leptadenia reticulata stems against carbon tetrachloride-induced hepatotoxicity in rats

    PubMed Central

    Nema, Amit Kumar; Agarwal, Abhinav; Kashaw, Varsha

    2011-01-01

    Objective: To evaluate the hepatoprotective activity of ethanolic and aqueous extract of stems of Leptadenia reticulata (Retz.) Wight. and Arn. in carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Materials and Methods: The toxicant CCl4 was used to induce hepatotoxicity at a dose of 1.25 ml/kg as 1 : 1 mixture with olive oil. Ethanolic and aqueous extracts of L. reticulata stems were administered in the doses of 250 and 500 mg/kg/day orally for 7 days. Silymarin (50 mg/kg) was used as standard drug. The hepatoprotective effect of these extracts was evaluated by the assessment of biochemical parameters such as serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, alkaline phosphatase, total bilirubin, serum protein, and histopathological studies of the liver. Results: Treatment of animals with ethanolic and aqueous extracts significantly reduced the liver damage and the symptoms of liver injury by restoration of architecture of liver as indicated by lower levels of serum bilirubin and protein as compared with the normal and silymarin-treated groups. Histology of the liver sections confirmed that the extracts prevented hepatic damage induced by CCl4 showing the presence of normal hepatic cords, absence of necrosis, and fatty infiltration. Conclusion: The ethanolic and aqueous extracts of stems of L. reticulata showed significant hepatoprotective activity. The ethanolic extract is more potent in hepatoprotection in CCl4-indiced liver injury model as compared with aqueous extract. PMID:21713086

  8. Structure-hepatoprotective activity relationship study of sesquiterpene lactones: A QSAR analysis

    NASA Astrophysics Data System (ADS)

    Paukku, Yuliya; Rasulev, Bakhtiyor; Syrov, Vladimir; Khushbaktova, Zainab; Leszczynski, Jerzy

    This study has been carried out using quantitative structure-activity relationship analysis (QSAR) for 22 sesquiterpene lactones to correlate and predict their hepatoprotective activity. Sesquiterpenoids, the largest class of terpenoids, are a widespread group of substances occurring in various plant organisms. QSAR analysis was carried out using methods such as genetic algorithm for variables selection among generated and calculated descriptors and multiple linear regression analysis. Quantum-chemical calculations have been performed by density functional theory at B3LYP/6-311G(d, p) level for evaluation of electronic properties using reference geometries optimized by semi-empirical AM1 approach. Three models describing hepatoprotective activity values for series of sesquiterpene lactones are proposed. The obtained models are useful for description of sesquiterpene lactones hepatoprotective activity and can be used to estimate the hepatoprotective activity of new substituted sesquiterpene lactones. The models obtained in our study show not only statistical significance, but also good predictive ability. The estimated predictive ability (rtest2) of these models lies within 0.942-0.969.

  9. Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Amorphophallus campanulatus Roxb. tubers.

    PubMed

    Jain, Sanjay; Dixit, Vinod K; Malviya, Neelesh; Ambawatia, Vijay

    2009-01-01

    In the present study, the hepatoprotective activity of ethanolic and aqueous extracts of Amorphophallus campanulatus (Roxb.) tubers were evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats. The extracts at a dose of 500 mg/kg were administered orally once daily. The substantially elevated serum enzymatic levels were significantly restored towards normalization by the extracts. Silymarin was used as a standard reference and exhibited significant hepatoprotective activity against carbon tetrachloride induced haptotoxicity in rats. The biochemical observations were supplemented with histopathological examination of rat liver sections. The results of this study strongly indicate that Amorphophallus campanulatus (Roxb.) tubers have potent hepatoprotective action against carbon tetrachloride induced hepatic damage in rats. The ethanolic extract was found hepatoprotective more potent than the aqueous extract. The antioxidant activity was also screened and found positive for both ethanolic and aqueous extracts. This study suggests that possible mechanism of this activity may be due to free radical scavenging potential caused by the presence of flavonoids in the extracts. PMID:19702175

  10. Effect of tax, financing, and operating-cost incentives on retiree homeowners' current and potential decisions to purchase energy-saving improvements

    SciTech Connect

    Long, A.W. Jr.

    1983-01-01

    This study focused on retiree homeowners to determine their level of participation, causes of non-participation and the effect of selected incentive modifications on investment decisions. A descriptive-elemental approach was taken to explore three research questions. Fifty semi-structured interviews selected through restricted probability were conducted in Sun City, California. Findings were keyed to sex, age, education and income and statistically analyzed using the chi-square test. Retiree homeowners had coped with rising utility costs through modified usage practice rather than through energy-saving investments. Concerns over access to funding, required initial payout, return on investment, future prices of energy and risk were highest among those of least education or income. A desire to retain an existing life style was important to those of higher education and income. Level of awareness of incentive features was also a major decision factor. The analysis indicated that energy-saving investments will increase if retiree homeowners are offered shared-cost obligation by the individual, government, and utility; exemption from sales tax for all energy-saving-item sales and service; state tax exemption for federal tax credits; exemption of energy-saving improvements from property tax; continued federal tax credit; investment loans sufficiently available to meet demand; energy-producing equipment available for rent or lease at reasonable rates.

  11. Energy savings and structural changes in the U.S. economy: Evidence from disaggregated data using decomposition techniques

    SciTech Connect

    Murtishaw, Scott; Schipper, Lee

    2001-12-01

    During the period 1973 to 1985, the U.S. economy saved energy in virtually every sector. Much of this period of energy saving was also marked by a significant drop in the ratio of energy use to GDP. However, since 1985 there has been a slowdown in the rate of energy saving, as key energy intensities (space heating, automobile driving, etc.) have declined less rapidly since 1985 than before. This paper examines delivered (or final) energy consumption trends from the early 1970s to 1994 and provides a framework for measuring key changes that affect U.S. energy use. Starting with estimates of outputs or activity levels for thirty major energy end uses, and energy intensities of each end use, we use the Adaptive Weighted Divisia decomposition to measure the impact of changes in the structure of the U.S. economy. In contrast to many similar decomposition studies, we define measures of structural changes for both households and branches of transportation. We find that between 1973 and 1985, lower energy intensities (corrected to average winter heating demand) reduced U.S. energy uses by about 1.7% per year, while structural changes reduced energy uses by 0.4% per year. After 1985, when oil prices declined markedly, intensities fell by only 0.8% per year and structural changes actually increased energy use by 0.4% per year. In the 1990s energy intensities in some industries have even edged upward. Changes in the ratio of energy to GDP (E/GDP) are affected both by intensities and the changes in the demand for energy services relative to GDP. During the first period, from 1973 to 1985, GDP increased faster than the growth in key structural and activity parameters that determine demand for energy services (such as home area, appliance ownership, and motor vehicle use) by 1.5% per year. From 1985 to 1994 the difference dropped to less than 0.3% per year, largely due to the reversal of structural trends. Thus, the sharp fall in the rate of decline in E/GDP from -3.1% to -1

  12. Assessment of China's Energy-Saving and Emission-Reduction Accomplishments and Opportunities During the 11th Five Year Plan

    SciTech Connect

    Levine, Mark D.; Price, Lynn; Zhou, Nan; Fridley, David; Aden, Nathaniel; Lu, Hongyou; McNeil, Michael; Zheng, Nina; Yining, Qin; Yowargana, Ping

    2010-04-28

    During the period 1980 to 2002, China experienced a 5% average annual reduction in energy consumption per unit of gross domestic product (GDP). The period 2002-2005 saw a dramatic reversal of the historic relationship between energy use and GDP growth: energy use per unit of GDP increased an average of 3.8% per year during this period (NBS, various years). China's 11th Five Year Plan (FYP), which covers the period 2006-2010, required all government divisions at different levels to reduce energy intensity by 20% in five years in order to regain the relationship between energy and GDP growth experienced during the 1980s and 1990s. This report provides an assessment of selected policies and programs that China has instituted in its quest to fulfill the national goal of a 20% reduction in energy intensity by 2010. The report finds that China has made substantial progress toward its goal of achieving 20% energy intensity reduction from 2006 to 2010 and that many of the energy-efficiency programs implemented during the 11th FYP in support of China's 20% energy/GDP reduction goal appear to be on track to meet - or in some cases even exceed - their energy-saving targets. It appears that most of the Ten Key Projects, the Top-1000 Program, and the Small Plant Closure Program are on track to meet or surpass the 11th FYP savings goals. China's appliance standards and labeling program, which was established prior to the 11th FYP, has become very robust during the 11th FYP period. China has greatly enhanced its enforcement of new building energy standards but energy-efficiency programs for buildings retrofits, as well as the goal of adjusting China's economic structure to reduce the share of energy consumed by industry, do not appear to be on track to meet the stated goals. With the implementation of the 11th FYP now bearing fruit, it is important to maintain and strengthen the existing energy-saving policies and programs that are successful while revising programs or adding new

  13. Developing Information on Energy Savings and Associated Costs and Benefits of Energy Efficient Emerging Technologies Applicable in California

    SciTech Connect

    Xu, Tengfang; Slaa, Jan Willem; Sathaye, Jayant

    2010-12-15

    Implementation and adoption of efficient end-use technologies have proven to be one of the key measures for reducing greenhouse gas (GHG) emissions throughout the industries. In many cases, implementing energy efficiency measures is among one of the most cost effective investments that the industry could make in improving efficiency and productivity while reducing carbon dioxide (CO2) emissions. Over the years, there have been incentives to use resources and energy in a cleaner and more efficient way to create industries that are sustainable and more productive. With the working of energy programs and policies on GHG inventory and regulation, understanding and managing the costs associated with mitigation measures for GHG reductions is very important for the industry and policy makers around the world and in California. Successful implementation of applicable emerging technologies not only may help advance productivities, improve environmental impacts, or enhance industrial competitiveness, but also can play a significant role in climate-mitigation efforts by saving energy and reducing the associated GHG emissions. Developing new information on costs and savings benefits of energy efficient emerging technologies applicable in California market is important for policy makers as well as the industries. Therefore, provision of timely evaluation and estimation of the costs and energy savings potential of emerging technologies applicable to California is the focus of this report. The overall goal of the project is to identify and select a set of emerging and under-utilized energy-efficient technologies and practices as they are important to reduce energy consumption in industry while maintaining economic growth. Specifically, this report contains the results from performing Task 3 Technology Characterization for California Industries for the project titled Research Opportunities in Emerging and Under-Utilized Energy-Efficient Industrial Technologies, sponsored by

  14. Research on the promotion measures to introduce new energy and energy-saving technologies with a leasing system

    NASA Astrophysics Data System (ADS)

    1994-03-01

    Effects of introducing the leasing system were studied in order to promote the introduction of photovoltaic power generation, wind power generation and other new energy technologies, and phosphoric acid fuel cell, regional air conditioning and other energy efficiency-heightening technologies. Judging from the result of investigating its needs, the introduction of leasing system is most effective when the technological reliability and safety have been established with a cost differential made small, to a certain extent, from the existing energy. The introduction of leasing system is considered effective not from the point of view that, in order to reduce the initial introduction cost, the leasing system is the best measures of investment in the facilities for the introduction of new energy and energy-saving technologies, but from the point of view that the addition of leasing system as one of the preferential measures widens the user's selectivity among the debt, self-funds and leasing. The following tasks are raised for the introduction of leasing system: Determination of leasing term, Determination of insurance rate, Study of leasing for the household use, Development of leasing system as commodities fulfilling the user's needs.

  15. Post Hoc Evaluation of Long-Term Goals for Energy Savings in the Buildings Sector: Lessons from Hindsight

    SciTech Connect

    Anderson, Dave M. ); Hostick, Donna J. )

    2003-04-28

    This report is one of two that re-examines the forecasted impact of individual programs currently within the Buildings Technology Program (BT) and the Weatherization and Intergovernmental Program (WIP) that appeared in the FY2000 Presidential Budget request. This report outlines the effects of re-estimating the FY 2000 budget request based on overlaying project data from subsequent years essentially revised out-year forecasts of project benefits. It shows that year-to-year long-term projections of primary energy savings can vary widely as models improve and programs change. Note that the FY2000 budget request was originally analyzed under the former Office of Building Technology, State and Community Programs (BTS), where BT and WIP were previously combined. Throughout the document, reference will be made to the predecessor of the BT and WIP programs, BTS, as FY2000 reflected that organization. A companion report develops potential methods for allowing inherent risk to be captured in the project benefits analysis. The point estimates in this paper are not influenced by uncertainty or risk. That report develops potential methods for allowing inherent risk to affect the benefits analysis via Monte Carlo simulation.

  16. FY 2000 Buildings Energy Savings Estimates under Uncertainty: Developing Approaches for Incorporating Risk into Buildings Program Energy Efficiency Estimates

    SciTech Connect

    Anderson, Dave M.

    2002-11-18

    This report is one of two that re-examines the forecasted impact of individual programs currently within the Buildings Technology Program (BT) and the Weatherization and Intergovernmental Program (WIP) that appeared in the FY2000 Presidential Budget request. This report develops potential methods for allowing inherent risk to be captured in the program benefits analysis. Note that the FY2000 budget request was originally analyzed under the former Office of Building Technology, State and Community Programs (BTS), where BT and WIP were previously combined. Throughout the document, reference will be made to the predecessor of the BT and WIP programs, BTS, as FY2000 reflected that organization. A companion report outlines the effects of re-estimating the FY 2000 budget request based on overlaying program data from subsequent years, essentially revised out-year forecasts. That report shows that year-to-year long-term projections of primary energy savings can vary widely as models improve and programs change. Those point estimates are not influenced by uncertainty or risk. This report develops potential methods for allowing inherent risk to affect the benefits analysis via Monte Carlo simulation.

  17. Preparation and energy-saving application of polyurethane/phase change composite materials for electrical water heaters

    NASA Astrophysics Data System (ADS)

    Hu, Yougen; Zhao, Tao; Wu, Xiaolin; Lai, Maobai; Jiang, Chengming; Sun, Rong

    2012-04-01

    Thermal energy storage plays an important role in heat management because of the demand for developed energy conservation, and has applications in diverse areas, from buildings to textiles and clothings. In this study, we aimed to improve thermal characteristics of polyurethane rigid foams that have been widely used for thermal insulation in electrical water heaters. Through this work, paraffin waxes with melting point of 55~65°C act as phase change materials. Then the phase change materials were incorporated into the polyurethane foams at certain ratio. The polyurethane/phase change composite materials used as insulation layers in electrical water heaters performed the enthalpy value of 5~15 J/g. Energy efficiency of the electrical water heaters was tested according to the National Standard of China GB 21519-2008. Results show that 24 h energy consumption of the electrical water heaters manufactured by traditional polyurethane rigid foams and polyurethane/phase change material composites was 1.0612 kWh and 0.9833 kWh, respectively. The results further show that the energy-saving rate is 7.36%. These proved that polyurethane/phase change composite materials can be designed as thermal insulators equipped with electrical water heaters and have a significant effect on energy conservation.

  18. Preparation and energy-saving application of polyurethane/phase change composite materials for electrical water heaters

    NASA Astrophysics Data System (ADS)

    Hu, Yougen; Zhao, Tao; Wu, Xiaolin; Lai, Maobai; Jiang, Chengming; Sun, Rong

    2011-11-01

    Thermal energy storage plays an important role in heat management because of the demand for developed energy conservation, and has applications in diverse areas, from buildings to textiles and clothings. In this study, we aimed to improve thermal characteristics of polyurethane rigid foams that have been widely used for thermal insulation in electrical water heaters. Through this work, paraffin waxes with melting point of 55~65°C act as phase change materials. Then the phase change materials were incorporated into the polyurethane foams at certain ratio. The polyurethane/phase change composite materials used as insulation layers in electrical water heaters performed the enthalpy value of 5~15 J/g. Energy efficiency of the electrical water heaters was tested according to the National Standard of China GB 21519-2008. Results show that 24 h energy consumption of the electrical water heaters manufactured by traditional polyurethane rigid foams and polyurethane/phase change material composites was 1.0612 kWh and 0.9833 kWh, respectively. The results further show that the energy-saving rate is 7.36%. These proved that polyurethane/phase change composite materials can be designed as thermal insulators equipped with electrical water heaters and have a significant effect on energy conservation.

  19. Study on impact of energy price comparison on energy saving benefits of heat pump in North China

    NASA Astrophysics Data System (ADS)

    Dong, X.; Tian, Q.; Zhang, Y. G.; Bai, H. F.

    2016-08-01

    As to the heat pump technology applying in the HVAC engineering, the relationship between energy saving rate (ESR) and electricity cost saving rate (ECSR) of heat pump should be a positive correlation in theory. But in the actual energy price system, due to the fluctuating energy price comparison, the relationship between them is of less coordination. Moreover, despite the high ESR, the economic benefit of ECSR is lost. In this paper, via the case analysis under the condition of average technical and economic parameters in North China, the critical point rate of economic benefit of ECSR in energy price comparison among prices of residential electricity, steam-coal, and residential natural gas is found, which is about 2:3:8. Also, a viewpoint as well as method is suggested to promote the wide usage of heat pump, balance energy supply structure, save energy consumption, and reduce emissions by optimizing the energy price comparison, which is feasible and desirable to raise the price comparison between residential electricity and natural gas, and reduce the price comparison between residential electricity and steam-coal in a certain extent.

  20. Building America Case Study: Low-Cost Evaluation of Energy Savings at the Community Scale, Fresno, California (Fact Sheet)

    SciTech Connect

    Not Available

    2014-10-01

    A new construction pilot community was constructed by builder-partner Wathen-Castanos Hybrid Homes (WCHH) based on a single occupied test house that was designed to achieve greater than 30% energy savings with respect to the House Simulation Protocols (Hendron, Robert; Engebrecht, Cheryn (2010). Building America House Simulation Protocols. Golden, CO: National Renewable Energy Laboratory.). Builders face several key problems when implementing a whole-house systems integrated measures package (SIMP) from a single test house into multiple houses. Although a technical solution already may have been evaluated and validated in an individual test house, the potential exists for constructability failures at the community scale. This report addresses factors of implementation and scalability at the community scale and proposes methodologies by which community-scale energy evaluations can be performed based on results at the occupied test house level. Research focused on the builder and trade implementation of a SIMP and the actual utility usage in the houses at the community scale of production. Five occupants participated in this community-scale research by providing utility bills and information on occupancy and miscellaneous gas and electric appliance use for their houses. IBACOS used these utility data and background information to analyze the actual energy performance of the houses. Verification with measured data is an important component in predictive energy modeling. The actual utility bill readings were compared to projected energy consumption using BEopt with actual weather and thermostat set points for normalization.

  1. Assessment of Building Energy-Saving Policies and Programs in China During the 11th Five Year Plan

    SciTech Connect

    Zhou, Nan; Mcneil, Michael; Levine, Mark

    2011-03-01

    China's 11th Five-Year Plan (FYP) sets an ambitious target to reduce the energy intensity per unit of gross domestic product (GDP) by 20% from 2005 to 2010 (NDRC, 2006). In the building sector, the primary energy-saving target allocated during the 11 FYP period is 100 Mtce. Savings are expected to be achieved through the strengthening of enforcement of building energy efficiency codes, existing building retrofits and heat supply system reform, followed by energy management of government office buildings and large scale public buildings, adoption of renewable energy sources. To date, China has reported that it achieved the half of the 20% intensity reduction target by the end of 2008, however, little has been made clear on the status and the impact of the building programs. There has also been lack of description on methodology for calculating the savings and baseline definition, and no total savings that have been officially reported to date. This paper intends to provide both quantitative and qualitative assessment of the key policies and programs in building sector that China has instituted in its quest to fulfill the national goal. Overall, this paper concludes that the largest improvement for building energy efficiency were achieved in new buildings; the program to improve the energy management in government and large scale public buildings are in line with the target; however the progress in the area of existing building retrofits, particularly heating supply system reform lags behind the stated goal by a large amount.

  2. Assessment of Building Energy-Saving Policies and Programs in China During the 11th Five Year Plan

    SciTech Connect

    Zhou, Nan; McNeil, Michael; Levine, Mark

    2010-06-07

    China's 11th Five-Year Plan (FYP) sets an ambitious target to reduce the energy intensity per unit of gross domestic product (GDP) by 20% from 2005 to 2010 (NDRC, 2006). In the building sector, the primary energy-saving target allocated during the 11 FYP period is 100 Mtce. Savings are expected to be achieved through the strengthening of enforcement of building energy efficiency codes, existing building retrofits and heat supply system reform, followed by energy management of government office buildings and large scale public buildings, adoption of renewable energy sources. To date, China has reported that it achieved the half of the 20% intensity reduction target by the end of 2008, however, little has been made clear on the status and the impact of the building programs. There has also been lack of description on methodology for calculating the savings and baseline definition, and no total savings that have been officially reported to date. This paper intend to provide both quantitative and qualitative assessment of the key policies and programs in building sector that China has instituted in its quest to fulfill the national goal. Overall, this paper concludes that the largest improvement for building energy efficiency were achieved in new buildings; the program to improve the energy management in government and large scale public buildings are in line with the target; however the progress in the area of existing building retrofit particularly heat supply system reform lags the stated goal by a large amount.

  3. Potential Energy Savings Due to Phase Change Material in a Building Wall Assembly: An Examination of Two Climates

    SciTech Connect

    Childs, Kenneth W; Stovall, Therese K

    2012-03-01

    Phase change material (PCM), placed in an exterior wall, alters the temperature profile within the wall and thus influences the heat transport through the wall. This may reduce the net energy transport through the wall via interactions with diurnal temperature swings in the external environment or reduce the electricity needed to meet the net load through the wall by shifting the time of the peak load to a time when the cooling system operates more efficiently. This study covers a broad range of parameters that can influence the effectiveness of such a merged thermal storage-thermal insulation system. These parameters included climate, PCM location within the wall, amount of PCM, midpoint of the PCM melting and freezing range relative to the indoor setpoint temperature, temperature range over which phase change occurs, and the wall orientation. Two climates are investigated using finite difference and optimization analyses: Phoenix and Baltimore, with two utility rate schedules. Although potential savings for a PCM with optimized properties were greater when the PCM was concentrated near the inside wall surface, other considerations described here lead to a recommendation for a full-thickness application. An examination of the temperature distribution within the walls also revealed the potential for this system to reduce the amount of energy transported through the wall framing. Finally, economic benefits can exceed energy savings when time-of-day utility rates are in effect, reflecting the value of peak load reductions for the utility grid.

  4. Functions and potential applications of glycolipid biosurfactants--from energy-saving materials to gene delivery carriers.

    PubMed

    Kitamoto, Dai; Isoda, Hiroko; Nakahara, Tadaatsu

    2002-01-01

    Biosurfactants (BS) produced by various microorganisms show unique properties (e.g., mild production conditions, lower toxicity, higher biodegradability and environmental compatibility) compared to their chemical counterparts. The numerous advantages of BS have prompted applications not only in the food, cosmetic, and pharmaceutical industries but in environmental protection and energy-saving technology as well. Glycolipid BS are the most promising, due to high productivity from renewable resources and versatile biochemical properties. Mannosylerythritol lipids (MEL), which are glycolipid BS produced by a yeast Candida antarctrica, exhibit not only excellent interfacial properties but also remarkable differentiation-inducing activities against human leukemia cells. MEL also show a potential anti-agglomeration effect on ice particles in ice slurry used for cold thermal storage. Recently, the cationic liposome bearing MEL has been demonstrated to increase dramatically the efficiency of gene transfection into mammalian cells. These features of BS should broaden its applications in new advanced technologies. The current status of research and development on glycolipid BS, especially their function and potential applications, is discussed. PMID:16233292

  5. Development of an energy-saving anaerobic hybrid membrane bioreactors for 2-chlorophenol-contained wastewater treatment.

    PubMed

    Wang, Yun-Kun; Pan, Xin-Rong; Sheng, Guo-Ping; Li, Wen-Wei; Shi, Bing-Jing; Yu, Han-Qing

    2015-12-01

    A novel energy-saving anaerobic hybrid membrane bioreactor (AnHMBR) with mesh filter, which takes advantage of anaerobic membrane bioreactor and fixed-bed biofilm reactor, is developed for low-strength 2-chlorophenol (2-CP)-contained wastewater treatment. In this system, the anaerobic membrane bioreactor is stuffed with granular activated carbon to construct an anaerobic hybrid fixed-bed biofilm membrane bioreactor. The effluent turbidity from the AnHMBR system was low during most of the operation period, and the chemical oxygen demand and 2-CP removal efficiencies averaged 82.3% and 92.6%, respectively. Furthermore, a low membrane fouling rate was achieved during the operation. During the AnHMBR operation, the only energy consumption was for feed pump. And a low energy demand of 0.0045-0.0063kWhm(-3) was estimated under the current operation conditions. All these results demonstrated that this novel AnHMBR is a sustainable technology for treating 2-CP-contained wastewater.

  6. Estimating the energy-saving benefit of reduced-flow and/or multi-speed commercial kitchen ventilation systems

    SciTech Connect

    Fisher, D.; Schmid, F.; Spata, A.J.

    1999-07-01

    Kitchen exhaust ventilation systems are recognized as a major energy user within commercial food service facilities and restaurants. Minimizing the design ventilation rate of an appliance/hood system by optimizing hood performance in the laboratory is a viable strategy for reducing the makeup air heating and cooling loads as well as the exhaust and supply fan energy. Cutting back the exhaust flow under conditions of noncooking (appliance idle) can further reduce the energy load associated with a kitchen ventilation system. An optimized, two-speed exhaust system was installed within the scope of an energy-efficient, quick service restaurant (QSR) design and demonstration project. This paper evaluates the energy benefit of this variable-flow strategy as well as the savings associated with reducing the design ventilation rate (compared to an off-the-shelf exhaust hood). The paper describes a new public-domain software tool for estimating heating and cooling loads associated with the makeup air requirements of commercial kitchens. This bin-based software provides ASHRAE engineers with an alternative to hand calculations or more sophisticated hour-by-hour simulation. The dramatic impact that both makeup air set point and geographic location have on the outdoor air load is illustrated. The paper concludes with an industry-wide projection of energy savings associated with optimizing the design and operation of commercial kitchen ventilation (CKV) systems.

  7. Analysis of Potential Energy Saving and CO2 Emission Reduction of Home Appliances and Commercial Equipments in China

    SciTech Connect

    Zhou, Nan; Fridley, David; McNeil, Michael; Zheng, Nina; Letschert, Virginie; Ke, Jing

    2011-04-01

    China has implemented a series of minimum energy performance standards (MEPS) for over 30 appliances, voluntary energy efficiency label for 40 products and a mandatory energy information label that covers 19 products to date. However, the impact of these programs and their savings potential has not been evaluated on a consistent basis. This paper uses modeling to estimate the energy saving and CO{sub 2} emission reduction potential of the appliances standard and labeling program for products for which standards are currently in place, under development or those proposed for development in 2010 under three scenarios that differ in the pace and stringency of MEPS development. In addition to a baseline 'Frozen Efficiency' scenario at 2009 MEPS level, the 'Continued Improvement Scenario' (CIS) reflects the likely pace of post-2009 MEPS revisions, and the likely improvement at each revision step. The 'Best Practice Scenario' (BPS) examined the potential of an achievement of international best practice efficiency in broad commercial use today in 2014. This paper concludes that under 'CIS', cumulative electricity consumption could be reduced by 9503 TWh, and annual CO{sub 2} emissions of energy used for all 37 products would be 16% lower than in the frozen efficiency scenario. Under a 'BPS' scenario for a subset of products, cumulative electricity savings would be 5450 TWh and annual CO{sub 2} emissions reduction of energy used for 11 appliances would be 35% lower.

  8. Least square based sliding mode control for a quad-rotor helicopter and energy saving by chattering reduction

    NASA Astrophysics Data System (ADS)

    Sumantri, Bambang; Uchiyama, Naoki; Sano, Shigenori

    2016-01-01

    In this paper, a new control structure for a quad-rotor helicopter that employs the least squares method is introduced. This proposed algorithm solves the overdetermined problem of the control input for the translational motion of a quad-rotor helicopter. The algorithm allows all six degrees of freedom to be considered to calculate the control input. The sliding mode controller is applied to achieve robust tracking and stabilization. A saturation function is designed around a boundary layer to reduce the chattering phenomenon that is a common problem in sliding mode control. In order to improve the tracking performance, an integral sliding surface is designed. An energy saving effect because of chattering reduction is also evaluated. First, the dynamics of the quad-rotor helicopter is derived by the Newton-Euler formulation for a rigid body. Second, a constant plus proportional reaching law is introduced to increase the reaching rate of the sliding mode controller. Global stability of the proposed control strategy is guaranteed based on the Lyapunov's stability theory. Finally, the robustness and effectiveness of the proposed control system are demonstrated experimentally under wind gusts, and are compared with a regular sliding mode controller, a proportional-differential controller, and a proportional-integral-differential controller.

  9. Purification, characterization and hepatoprotective activities of mycelia zinc polysaccharides by Pleurotus djamor.

    PubMed

    Zhang, Jianjun; Liu, Min; Yang, Yongheng; Lin, Lin; Xu, Nuo; Zhao, Huajie; Jia, Le

    2016-01-20

    This study was designed to investigate the physicochemical properties (molecular weights, bond types and monosaccharide compositions), antioxidant activities, and hepatoprotective effects on carbon tetrachloride (CCl4)-induced acute liver damage of mycelia zinc polysaccharides (MZPSs) and its major fractions (MZPS-1, -2 and -3) separated from Pleurotus djamor. In vitro assays, the MZPS-3 demonstrated relatively strong antioxidant activities in dose-dependent manners. For in vivo hepatoprotective activities, administration of MZPS-3 at 800 mg/kg significantly decreased the levels of AST, ALT, MDA and LPO, remarkably increased the levels of TC, TG and ALB, and prominently restored the activities of SOD, GSH-Px, CAT and T-AOC in serum/liver homogenate against CCl4-induced injures. Findings presented in this study clearly demonstrated that MZPSs, especially MZPS-3, might be suitable for functional foods and natural drugs in preventing the CCl4-induced acute liver damage.

  10. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial

    PubMed Central

    Marjani, Majid; Baghaei, Parvaneh; Kazempour Dizaji, Mehdi; Gorji Bayani, Pegah; Fahimi, Fanak; Tabarsi, Payam; Velayati, Ali Akbar

    2016-01-01

    Abstract: Hepatic toxicity is the most serious adverse effect of anti-tuberculosis drugs. This study was performed to evaluate the efficacy of silymarin as a hepatoprotective herbal agent. In a randomized double blind clinical trial, 70 new cases of pulmonary tuberculosis were divided into two groups. The intervention group was assigned to receive silymarin and the control group received placebo. Tuberculosis was treated by classic regimen consisting isoniazid, rifampin, pyrazinamide and ethambutol. No statistically significant difference was found between the two groups concerning the frequency of drug induced liver injury or mild elevation of liver enzymes. Silymarin was safe without any major side effect. Our results showed no significant hepatoprotective effect of silymarin among patients on tuberculosis treatment. PMID:27610165

  11. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.

    PubMed

    Marjani, Majid; Baghaei, Parvaneh; Kazempour Dizaji, Mehdi; Gorji Bayani, Pegah; Fahimi, Fanak; Tabarsi, Payam; Velayati, Ali Akbar

    2016-01-01

    Hepatic toxicity is the most serious adverse effect of anti-tuberculosis drugs. This study was performed to evaluate the efficacy of silymarin as a hepatoprotective herbal agent. In a randomized double blind clinical trial, 70 new cases of pulmonary tuberculosis were divided into two groups. The intervention group was assigned to receive silymarin and the control group received placebo. Tuberculosis was treated by classic regimen consisting isoniazid, rifampin, pyrazinamide and ethambutol. No statistically significant difference was found between the two groups concerning the frequency of drug induced liver injury or mild elevation of liver enzymes. Silymarin was safe without any major side effect. Our results showed no significant hepatoprotective effect of silymarin among patients on tuberculosis treatment. PMID:27610165

  12. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial

    PubMed Central

    Marjani, Majid; Baghaei, Parvaneh; Kazempour Dizaji, Mehdi; Gorji Bayani, Pegah; Fahimi, Fanak; Tabarsi, Payam; Velayati, Ali Akbar

    2016-01-01

    Abstract: Hepatic toxicity is the most serious adverse effect of anti-tuberculosis drugs. This study was performed to evaluate the efficacy of silymarin as a hepatoprotective herbal agent. In a randomized double blind clinical trial, 70 new cases of pulmonary tuberculosis were divided into two groups. The intervention group was assigned to receive silymarin and the control group received placebo. Tuberculosis was treated by classic regimen consisting isoniazid, rifampin, pyrazinamide and ethambutol. No statistically significant difference was found between the two groups concerning the frequency of drug induced liver injury or mild elevation of liver enzymes. Silymarin was safe without any major side effect. Our results showed no significant hepatoprotective effect of silymarin among patients on tuberculosis treatment.

  13. Hepatoprotective activity of dried- and fermented-processed virgin coconut oil.

    PubMed

    Zakaria, Z A; Rofiee, M S; Somchit, M N; Zuraini, A; Sulaiman, M R; Teh, L K; Salleh, M Z; Long, K

    2011-01-01

    The present study aims to determine the hepatoprotective effect of MARDI-produced virgin coconut oils, prepared by dried- or fermented-processed methods, using the paracetamol-induced liver damage in rats. Liver injury induced by 3 g/kg paracetamol increased the liver weight per 100 g bodyweight indicating liver damage. Histological observation also confirms liver damage indicated by the presence of inflammations and necrosis on the respective liver section. Interestingly, pretreatment of the rats with 10, but not 1 and 5, mL/kg of both VCOs significantly (P < .05) reduced the liver damage caused by the administration of paracetamol, which is further confirmed by the histological findings. In conclusion, VCO possessed hepatoprotective effect that requires further in-depth study.

  14. Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil

    PubMed Central

    Zakaria, Z. A.; Rofiee, M. S.; Somchit, M. N.; Zuraini, A.; Sulaiman, M. R.; Teh, L. K.; Salleh, M. Z.; Long, K.

    2011-01-01

    The present study aims to determine the hepatoprotective effect of MARDI-produced virgin coconut oils, prepared by dried- or fermented-processed methods, using the paracetamol-induced liver damage in rats. Liver injury induced by 3 g/kg paracetamol increased the liver weight per 100 g bodyweight indicating liver damage. Histological observation also confirms liver damage indicated by the presence of inflammations and necrosis on the respective liver section. Interestingly, pretreatment of the rats with 10, but not 1 and 5, mL/kg of both VCOs significantly (P < .05) reduced the liver damage caused by the administration of paracetamol, which is further confirmed by the histological findings. In conclusion, VCO possessed hepatoprotective effect that requires further in-depth study. PMID:21318140

  15. Hepatoprotective effects of Astragalus kahiricus root extract against ethanol-induced liver apoptosis in rats.

    PubMed

    Allam, Rasha M; Selim, Dina A; Ghoneim, Asser I; Radwan, Mohamed M; Nofal, Salwa M; Khalifa, Amani E; Sharaf, Ola A; Toaima, Soad M; Asaad, Aya M; El-Sebakhy, Nadia A

    2013-07-01

    The hepatoprotective activity of the ethanol extract of Astragalus kahiricus (Fabaceae) roots against ethanol-induced liver apoptosis was evaluated and it showed very promising hepatoprotective actions through different mechanisms. The extract counteracted the ethanol-induced liver enzymes leakage and glutathione depletion. In addition, it demonstrated anti-apoptotic effects against caspase-3 activation and DNA fragmentation that were confirmed by liver histopathological examination. Moreover, the phytochemical study of this extract led to the isolation of four cycloartane-type triterpenes identified as astrasieversianin II (1), astramembrannin II (2), astrasieversianin XIV (3), and cycloastragenol (4). The structures of these isolates were established by HRESI-MS and 1D and 2D NMR experiments. The antimicrobial, antimalarial, and cytotoxic activities of the isolates were further evaluated, but none of them showed any activity.

  16. Hepatoprotective activity of methanolic extract of Syzygium jambos (Linn.) leaf against paracetamol intoxicated Wistar albino rats

    PubMed Central

    Selvam, N. Thamizh; Venkatakrishnan, V.; Dhamodharan, R.; Murugesan, S.; Kumar, S. Damodar

    2013-01-01

    Hepatoprotective activity of methanolic extract of Syzygium jambos (Alston) (Linn.) leaves against Paracetamol-induced hepatic damage in Wistar albino rats was observed at two different doses, 100 and 200 mg/kg body weight. The healthy control, disease control, and standard drug Silymarin-treated groups were also maintained for the comparison. The liver marker enzymes SGOT, SGPT, ALKP, Serum Bilirubin and other metabolic parameters like total cholesterol, HDL-cholesterol were evaluated in all the experimental groups. The changes in liver function parameters were significant in comparison to disease control group and the observed efficacy was comparable to standard drug. The efficacy of the extract was found to be dose dependent. The histopathology study of liver also supports the presence of hepatoprotective activity in S. jambos by showing improved cytoarchitecture of liver cells in the treated groups. The results obtained in this study indicate necessity for further research on isolation and characterization of functional molecules from the extract. PMID:24501529

  17. Hepatoprotective activity of methanolic extract of Syzygium jambos (Linn.) leaf against paracetamol intoxicated Wistar albino rats.

    PubMed

    Selvam, N Thamizh; Venkatakrishnan, V; Dhamodharan, R; Murugesan, S; Kumar, S Damodar

    2013-07-01

    Hepatoprotective activity of methanolic extract of Syzygium jambos (Alston) (Linn.) leaves against Paracetamol-induced hepatic damage in Wistar albino rats was observed at two different doses, 100 and 200 mg/kg body weight. The healthy control, disease control, and standard drug Silymarin-treated groups were also maintained for the comparison. The liver marker enzymes SGOT, SGPT, ALKP, Serum Bilirubin and other metabolic parameters like total cholesterol, HDL-cholesterol were evaluated in all the experimental groups. The changes in liver function parameters were significant in comparison to disease control group and the observed efficacy was comparable to standard drug. The efficacy of the extract was found to be dose dependent. The histopathology study of liver also supports the presence of hepatoprotective activity in S. jambos by showing improved cytoarchitecture of liver cells in the treated groups. The results obtained in this study indicate necessity for further research on isolation and characterization of functional molecules from the extract. PMID:24501529

  18. Hepatoprotective activity of Haridradi ghrita on carbon tetrachloride-induced liver damage in rats.

    PubMed

    Satturwar, P M; Fulzele, S V; Joshi, S B; Dorle, A K

    2003-12-01

    Haridradi ghrita, a ghee based polyherbal formulation, (50, 100, 200 and 300 mg/kg) significantly lowered marker enzymes (SGPT, SGOT, ALP) and bilirubin in serum and liver peroxide, superoxide dismutase and catalase in liver homogenate following CCl4 (0.7 ml/kg, ip) toxicity. The protective effect was further supported by reversal of CCl4 induced histological changes. The results demonstrate significant hepatoprotective action of H. ghrita in CCl4 damaged rats. PMID:15320500

  19. Building America Residential System Research Results: Achieving 30% Whole House Energy Savings Level in Mixed-Humid Climates; January 2006 - December 2006

    SciTech Connect

    Building America Industrialized Housing Partnership; Building Industry Research Alliance; Building Science Consortium; Consortium for Advanced Residential Buildings; Davis Energy Group; IBACOS; National Association of Home Builders Research Center; National Renewable Energy Laboratory

    2006-12-01

    The Building America program conducts the system research required to reduce risks associated with the design and construction of homes that use an average of 30% to 90% less total energy for all residential energy uses than the Building America Research Benchmark, including research on homes that will use zero net energy on annual basis. To measure the program's progress, annual research milestones have been established for five major climate regions in the United States. The system research activities required to reach each milestone take from 3 to 5 years to complete and include research in individual test houses, studies in pre-production prototypes, and research studies with lead builders that provide early examples that the specified energy savings level can be successfully achieved on a production basis. This report summarizes research results for the 30% energy savings level and demonstrates that lead builders can successfully provide 30% homes in the Mixed-Humid Climate Region on a cost-neutral basis.

  20. Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats.

    PubMed

    Achliya, Girish S; Wadodkar, Sudhir G; Dorle, Avinash K

    2004-02-01

    Amalkadi Ghrita (AG), a polyherbal formulation, was evaluated for its hepatoprotective activity against carbon tetrachloride (CCl4)-induced hepatic damage in rats. The hepatoprotective activity of AG was evaluated by measuring levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), and acid phosphatase (ACP). The serum levels of total proteins and bilirubin were also estimated. The histological studies were also carried out to support the above parameters. Silymarin was used as standard drug. Administration of AG (100 and 300 mg/kg, p.o.) markedly prevented CCl4-induced elevation of levels of serum GPT, GOT, ACP, ALP, and bilirubin. The decreased level of total proteins due to hepatic damage induced by CCl4 was found to be increased in AG-treated group. The results are comparable to that of silymarin. A comparative histopathological study of liver exhibited almost normal architecture, as compared to CCl4-treated group. Hepatoprotective effect of AG is probably due to combined action of all ingredients. PMID:15013185

  1. Hepatoprotective effect of biherbal ethanolic extract against paracetamol-induced hepatic damage in albino rats

    PubMed Central

    Anantha, Krishna Chaitanya D.; Siva, Reddy Challa; Manohar, Reddy A.

    2012-01-01

    Aim: The combined hepatoprotective effect of Bi-herbal ethanolic extract (BHEE) was evaluated against paracetamol induced hepatic damage in albino rats. Materials and Methods: Liver function tests and biochemical parameters were estimated using standard kits. Livers were quickly removed and fixed in 10% formalin and subjected to histopathological studies. Results: Ethanolic extract from the leaves of Aerva lanata and leaves of Achyranthes aspera at a dose level of 200 mg/kg, 400mg/kg body weight was administered orally once for 3 days. Substantially elevated serum marker enzymes such as SGOT, SGPT, ALP, due to paracetamol treatment were restored towards normal. Biochemical parameters like total protein, total bilirubin, total cholesterol, triglycerides, and urea were also restored towards normal levels. In addition, BHEE significantly decreased the liver weight of paracetamol intoxicated rats. Silymarin at a dose level of 25 mg/kg used as a standard reference also exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity. Conclusion: The results of this study strongly indicate that BHEE has got a potent hepatoprotective action against paracetamol induced hepatic damage in rats. PMID:23326091

  2. Hepatoprotective Efficacy of Cichorium intybus L. Extract Against Carbon Tetrachloride-induced Liver Damage in Rats.

    PubMed

    Elgengaihi, Souad; Mossa, Abdel-Tawab H; Refaie, Amel A; Aboubaker, Doha

    2016-01-01

    The purpose of the study was to assess the phytochemical and hepatoprotective activity of different extracts of dried herb of Cichorium intybus L. against carbon tetrachloride (CCl4) intoxicated male albino rats. The hepatoprotective activity of different extracts at 500 mg/kg body weight was compared with carbon tetrachloride-treated animals. The animals were divided into five groups with six animals in each group. The first group represents control, the second group received carbon tetrachloride, the third received C. intybus, and the fourth group received C. intybus plus carbon tetrachloride. The fifth group received silymarin as hepato-slandered drug. There were significant changes in serum biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin, albumin, total protein, and γ-glutamyl transferase (GGT) in carbon tetrachloride intoxicated rats, which were restored towards normal values in C. intybus-treated animals. Histopathological examination of liver tissues further substantiated these findings. In conclusion, of this investigation, the results ascertain that the herb extracts of C. intybus possess significant hepatoprotective activity. PMID:26913368

  3. Antioxidant, Analgesic, Anti-Inflammatory, and Hepatoprotective Effects of the Ethanol Extract of Mahonia oiwakensis Stem

    PubMed Central

    Chao, Jung; Liao, Jiunn-Wang; Peng, Wen-Huang; Lee, Meng-Shiou; Pao, Li-Heng; Cheng, Hao-Yuan

    2013-01-01

    The aim of this study was to evaluate pharmacological properties of ethanol extracted from Mahonia oiwakensis Hayata stems (MOSEtOH). The pharmacological properties included antioxidant, analgesic, anti-inflammatory and hepatoprotective effects. The protoberberine alkaloid content of the MOSEtOH was analyzed by high-performance liquid chromatography (HPLC). The results revealed that three alkaloids, berberine, palmatine and jatrorrhizine, could be identified. Moreover, the MOSEtOH exhibited antioxidative activity using the DPPH assay (IC50, 0.743 mg/mL). The DPPH radical scavenging activity of MOSEtOH was five times higher that that of vitamin C. MOSEtOH was also found to inhibit pain induced by acetic acid, formalin, and carrageenan inflammation. Treatment with MOSEtOH (100 and 500 mg/kg) or silymarin (200 mg/kg) decreased the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels compared with the CCl4-treated group. Histological evaluation showed that MOSEtOH reduced the degree of liver injury, including vacuolization, inflammation and necrosis of hepatocytes. The anti-inflammatory and hepatoprotective effect of MOSEtOH were found to be related to the modulation of antioxidant enzyme activity in the liver and decreases in malondialdehyde (MDA) level and nitric oxide (NO) contents. Our findings suggest that MOSEtOH has analgesic, anti-inflammatory and hepatoprotective effects. These effects support the use of MOSEtOH for relieving pain and inflammation in folk medicine. PMID:23364614

  4. Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats

    PubMed Central

    Tatiya, Anil U.; Surana, Sanjay J.; Sutar, Manisha P.; Gamit, Nehal H.

    2012-01-01

    Background: Individually Andrographis paniculata Nees. (Acanthaceae), Phyllanthus niruri Linn.(Euphorbiaceae) and Phyllanthus emblica Linn. single plant extracts have been reported to have hepatoprotective activity. However, literature survey shows that no sufficient scientific data has been publish on pharmacological evaluation of these plants in combined form. Method: Hepatoprotective activity of the polyherbal hepatoprotaective formulation (PHF)-containing spray-dried aqueous extracts of Andrographis paniculata Nees. (Acanthaceae), Phyllanthus niruri Linn. (Euphorbiaceae) and Phyllanthus emblica Linn. (Euphorbiaceae), was screened against paracetamol, carbon tetrachloride (CCl4), and ethanol-induced hepatic damage in rats. PHF was evaluated by measuring levels of serum marker enzymes like SGOT, SGPT, ALP, direct bilirubin (DB), and lactate dehydrogenase (LDH). The histological studies were also studied support the biochemical parameters. Silymarin was used as standard drug. Results: Administration of PHF (100 and 200 mg/kg p.o.) significantly inhibited paracetamol, CCl4 and ethanol-induced elevation levels of SGPT, SGOT, ALP, DB and LDH. A comparative histopathological study of liver exhibited almost normal architecture as compared to toxicant group. Conclusion: Results suggests that the hepatoprotective effects of PHF might be useful for liver protection due to combined action of all plant extracts along with their phytoconstituents. PMID:22224062

  5. Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate

    SciTech Connect

    Moffit, Jeffrey S.; Koza-Taylor, Petra H.; Holland, Ricky D.; Thibodeau, Michael S.; Beger, Richard D.; Lawton, Michael P.; Manautou, Jose E. . E-mail: jose.manautou@uconn.edu

    2007-07-15

    Pretreatment of mice with the peroxisome proliferator clofibrate (CFB) protects against acetaminophen (APAP)-induced hepatotoxicity. Previous studies have shown that activation of the nuclear peroxisome proliferator activated receptor-alpha (PPAR{alpha}) is required for this effect. The present study utilizes gene expression profile analysis to identify potential pathways contributing to PPAR{alpha}-mediated hepatoprotection. Gene expression profiles were compared between wild type and PPAR{alpha}-null mice pretreated with vehicle or CFB (500 mg/kg, i.p., daily for 10 days) and then challenged with APAP (400 mg/kg, p.o.). Total hepatic RNA was isolated 4 h after APAP treatment and hybridized to Affymetrix Mouse Genome MGU74 v2.0 GeneChips. Gene expression analysis was performed utilizing GeneSpring (registered) software. Our analysis identified 53 genes of interest including vanin-1, cell cycle regulators, lipid-metabolizing enzymes, and aldehyde dehydrogenase 2, an acetaminophen binding protein. Vanin-1 could be important for CFB-mediated hepatoprotection because this protein is involved in the synthesis of cysteamine and cystamine. These are potent antioxidants capable of ameliorating APAP toxicity in rodents and humans. HPLC-ESI/MS/MS analysis of liver extracts indicates that enhanced vanin-1 gene expression results in elevated cystamine levels, which could be mechanistically associated with CFB-mediated hepatoprotection.

  6. Antioxidant and hepatoprotective properties of dried fig against oxidative stress and hepatotoxicity in rats.

    PubMed

    Turan, Abdullah; Celik, Ismail

    2016-10-01

    The aim of this study was to investigate the hepatoprotective effect and antioxidant role of dried fig (DF) (Ficus carica L.) against ethanol-induced oxidative stress. Experiment was designed as normal Control, 20% ethanol, 10% DF and 10% DF+20% ethanol groups. The hepatoprotective and antioxidant role of the dried DF supplementation feed against ethanol induced oxidatif stress were evaluated by liver histopathological changes, measuring liver damage serum enzymes (LDSE), antioxidant defense system (ADS) and malondialdehyde (MDA) content in various tissues of rats following the exposure of experimental for 50days. The biochemical analysis showed a considerable increase the LDSE in the ethanol group as compared to that of control group whereas, decreased in 10% DF+20% ethanol group as compared to that of ethanol group. In addition, the DF supplementation diet restored the ethanol-induced MDA and ADS towards to control. The hepatoprotection of DF is further substantiated by the almost normal histologic findings of liver in 10% DF+20% ethanol group against degenerative changes in ethanol group. The results indicated that the DF could be as important as diet-derived antioxidants and antihepatotoxicity in preventing oxidative damage in the tissues by inhibiting the production of ethanol-induced free radicals and hepatotoxicity in rats. PMID:27268385

  7. Hepatoprotective effect of Ginkgo biloba leaf extract on lantadenes-induced hepatotoxicity in guinea pigs.

    PubMed

    Parimoo, Haroon A; Sharma, Rinku; Patil, Rajendra D; Sharma, Om P; Kumar, Pawan; Kumar, Neeraj

    2014-04-01

    The hepatoprotective effect of freeze-dried methanolic leaf extract of Ginkgo biloba was evaluated against lantadenes-induced hepatic damage in guinea pigs. The reversed-phase HPLC analysis of lantadenes confirmed the presence of 72.82% of lantadene A. UPLC-ESI-MS analysis showed the presence of ginkgolide B, C, bilobalide and traces of ginkgolide A and J in G. biloba extract. The concentration of ginkgolide B in the sample was found as 0.29%. The elevated levels of serum alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase due to lantadenes were significantly restored towards normal values by G. biloba extract in a dose-dependent manner. The effects of lantadenes and G. biloba extract on lipid peroxidation (LPO), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase were assayed in liver homogenates to evaluate the antioxidant activity. G. biloba extract in a dose-dependent manner produced significant decrease in lantadenes-induced increased levels of LPO. The lantadene-induced decreased levels of SOD, GSH and catalase were elevated by G. biloba extract. The findings of biochemical and antioxidant enzyme levels were supported by gross and histopathological observations. Moreover, liver sections of G. biloba group also showed a marked decrease in apoptosis in comparison to lantadenes group. This study suggested that G. biloba could be used as a promising hepatoprotectant against lantadenes-induced hepatic damage. Future studies are needed to elucidate the precise mechanism of hepatoprotection for practical application.

  8. Hepatoprotective and antiviral efficacy of Acacia mellifera leaves fractions against hepatitis B virus.

    PubMed

    Arbab, Ahmed H; Parvez, Mohammad K; Al-Dosari, Mohammed S; Al-Rehaily, Adnan J; Al-Sohaibani, Mohammed; Zaroug, Elwaleed E; AlSaid, Mansour S; Rafatullah, Syed

    2015-01-01

    The present study investigated the hepatoprotective and anti-HBV efficacy of Acacia mellifera (AM) leaves extracts. The crude ethanolic-extract, including organic and aqueous fractions, were tested for cytotoxicity on HepG2 and HepG2.2.15 cells (IC50=684 μg/mL). Of these, the ethyl acetate and aqueous fractions showed the most promising, dose-dependent hepatoprotection in DCFH-toxicated cells at 48 h. In CCl4-injured rats, oral administration of AM ethanol extract (250 and 500 mg/kg·bw) for three weeks significantly normalized the sera aminotransferases, alkaline phosphatase, bilirubin, cholesterol, triglycerides, and lipoprotein levels and elevated tissue nonprotein sulphydryl and total protein. The histopathology of dissected livers also revealed that AM cured the tissue lesions. The phytochemical screening of the fractions showed presence of alkaloids, flavonoids, tannins, sterols, and saponins. Further, anti-HBV potential of the fractions was evaluated on HepG2.2.15 cells. Of these, the n-butanol and aqueous fractions exhibited the best inhibitory effects on HBsAg and HBeAg expressions in dose- and time-dependent manner. Taken together, while the ethyl acetate and aqueous fractions exhibited the most promising antioxidant/hepatoprotective and anti-HBV activity, respectively, the n-butanol partition showed both activities. Therefore, the therapeutic potential of AM extracts warrants further isolation of the active principle(s) and its phytochemical as well as biological studies.

  9. Antioxidant and hepatoprotective properties of Indian Sunderban mangrove Bruguiera gymnorrhiza L. leave

    PubMed Central

    Sur, Tapas Kumar; Hazra, Avijit; Hazra, Alok Kumar; Bhattacharyya, Dipankar

    2016-01-01

    Background: Bruguiera gymnorrhiza L. (family Rhizophoraceae) is a true mangrove habitat in Indian Sunderban and traditionally uses for liver disorders. Objectives: The aim was to evaluate antioxidant and hepatoprotective actions of leave extract of B. gymnorrhiza L. Materials and Methods: Hydro-methanolic extract of mangrove leaves (BR) was standardized using spectrophotometric and high-performance thin layer chromatography methods. Radical scavenging activities were assessed in different in vitro methods, like 1,1-diphenyl-2-picrylhydrazyl, 2,2’-azino-bis-3-ethyl benzthiazoline-6-sulphonic acid +, superoxides, nitric oxides and hydroxyl radicals. Hepatoprotective efficacy of BR (125 mg/kg and 250 mg/kg, p.o) was measured in D-galactosamine (GalN) induced (200 mg/kg, i.p) hepatitis in Wistar rats. Silymarin (25 mg/kg, p.o) was used as known hepatoprotective agent. Results: Polyphenols such as gallic acid, quercetin, and coumarin obtained from BR exhibited powerful antioxidant properties. Moreover, it produced dose-dependent protection against GalN induced hepatitis in rats. It significantly reduced GalN induced elevation of enzymes (alanine transaminase, aspartate aminotransferase, and alkaline phosphatase) in serum and resist oxidative stress marked by lipid peroxides, glutathione, and catalase in hepatic parenchyma. Conclusions: Polyphenols rich B. gymnorrhiza L. leaves ameliorate hepatic tissue injury through its antioxidant effects. PMID:27330259

  10. Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats

    PubMed Central

    Anusha, M.; Venkateswarlu, M.; Prabhakaran, V.; Taj, S. Shareen; Kumari, B. Pushpa; Ranganayakulu, D.

    2011-01-01

    Objective: To investigate the hepatoprotective activity of the aqueous extract of the aerial parts of Portulaca oleracea (P. oleracea) in combination with lycopene against carbon tetrachloride induced hepatotoxicity in rats. Materials and Methods: Hepatotoxicity was induced in male Wistar rats by intraperitoneal injection of carbon tetrachloride (0.1 ml/kg b.w for 14 days). The aqueous extract of P. oleracea in combination with lycopene (50 mg/kg b.w) was administered to the experimental animals at two selected doses for 14 days. The hepatoprotective activity of the combination was evaluated by the liver function marker enzymes in the serum [aspartate transaminases (AST), alanine transaminases (ALT), alkaline phosphatase (Alk.P), total bilirubin (TB), total protein (TP) and total cholesterol (TC)], pentobarbitone induced sleeping time (PST) and histopathological studies of liver. Results: Both the treatment groups showed hepatoprotective effect against carbon tetrachloride induced hepatotoxicity by significantly restoring the levels of serum enzymes to normal which was comparable to that of silymarin group. Besides, the results obtained from PST and histopathological results also support the study. Conclusions: The oral administration of P. oleracea in combination with lycopene significantly ameliorates CCl4 hepatotoxicity in rats. PMID:22022001

  11. Hepatoprotective Effect of Houttuynia cordata Thunb Extract against Carbon Tetrachloride-induced Hepatic Damage in Mice

    PubMed Central

    Kang, H.; Koppula, S.

    2014-01-01

    Houttuynia cordata Thunb (Saururaceae) is a traditional medicinal herb used to treat several disease symptoms. The present study was focused on the hepatoprotective effects of H. cordata ethyl acetate extract in experimental mice. Further the antioxidant potential of the extract was also evaluated to substantiate its hepatoprotective properties. Carbon tetrachloride-induced hepatic damage in mice was used to measure the serum biochemical parameters. Morphological changes in hepatocyte architecture were studied by haematoxylin and eosin staining. In vitro alkyl and hydroxyl free radical scavenging assays were performed to evaluate the antioxidant effect. Administration of H. cordata extract significantly reduced the elevated serum levels and regulated the altered levels of serum cholesterol in carbon tetrachloride-treated mice (P<0.05). The morphological changes in hepatocyte architecture were also reversed by H. cordata treatment. Further, the extract showed significant antioxidant actions by scavenging the alkyl and hydroxyl free radicals. The concentration of the extract necessary for 50% scavenging of alkyl and hydroxyl radicals was 15.5 and 410 μg/ml, respectively. H. cordata extract exhibited significant hepatoprotective property in carbon tetrachloride-induced hepatotoxicity in mice. The strong antioxidant activities possessed by the extract might be responsible for such actions. PMID:25284923

  12. Hepatoprotective Effect of Houttuynia cordata Thunb Extract against Carbon Tetrachloride-induced Hepatic Damage in Mice.

    PubMed

    Kang, H; Koppula, S

    2014-07-01

    Houttuynia cordata Thunb (Saururaceae) is a traditional medicinal herb used to treat several disease symptoms. The present study was focused on the hepatoprotective effects of H. cordata ethyl acetate extract in experimental mice. Further the antioxidant potential of the extract was also evaluated to substantiate its hepatoprotective properties. Carbon tetrachloride-induced hepatic damage in mice was used to measure the serum biochemical parameters. Morphological changes in hepatocyte architecture were studied by haematoxylin and eosin staining. In vitro alkyl and hydroxyl free radical scavenging assays were performed to evaluate the antioxidant effect. Administration of H. cordata extract significantly reduced the elevated serum levels and regulated the altered levels of serum cholesterol in carbon tetrachloride-treated mice (P<0.05). The morphological changes in hepatocyte architecture were also reversed by H. cordata treatment. Further, the extract showed significant antioxidant actions by scavenging the alkyl and hydroxyl free radicals. The concentration of the extract necessary for 50% scavenging of alkyl and hydroxyl radicals was 15.5 and 410 μg/ml, respectively. H. cordata extract exhibited significant hepatoprotective property in carbon tetrachloride-induced hepatotoxicity in mice. The strong antioxidant activities possessed by the extract might be responsible for such actions. PMID:25284923

  13. Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats

    PubMed Central

    Wong, Wei-Lun; Abdulla, Mahmood Ameen; Chua, Kek-Heng; Kuppusamy, Umah Rani; Tan, Yee-Shin; Sabaratnam, Vikineswary

    2012-01-01

    Panus giganteus, a culinary and medicinal mushroom consumed by selected indigenous communities in Malaysia, is currently being considered for large scale cultivation. This study was undertaken to investigate the hepatoprotective effects of P. giganteus against thioacetamide- (TAA-) induced liver injury in Sprague-Dawley rats. The rats were injected intraperitoneally with TAA thrice weekly and were orally administered freeze-dried fruiting bodies of P. giganteus (0.5 or 1 g/kg) daily for two months, while control rats were given vehicle or P. giganteus only. After 60 days, rats administered with P. giganteus showed lower liver body weight ratio, restored levels of serum liver biomarkers and oxidative stress parameters comparable to treatment with the standard drug silymarin. Gross necropsy and histopathological examination further confirmed the hepatoprotective effects of P. giganteus. This is the first report on hepatoprotective effects of P. giganteus. The present study showed that P. giganteus was able to prevent or reduce the severity of TAA-induced liver injury. PMID:22649470

  14. Antioxidant and hepatoprotective properties of dried fig against oxidative stress and hepatotoxicity in rats.

    PubMed

    Turan, Abdullah; Celik, Ismail

    2016-10-01

    The aim of this study was to investigate the hepatoprotective effect and antioxidant role of dried fig (DF) (Ficus carica L.) against ethanol-induced oxidative stress. Experiment was designed as normal Control, 20% ethanol, 10% DF and 10% DF+20% ethanol groups. The hepatoprotective and antioxidant role of the dried DF supplementation feed against ethanol induced oxidatif stress were evaluated by liver histopathological changes, measuring liver damage serum enzymes (LDSE), antioxidant defense system (ADS) and malondialdehyde (MDA) content in various tissues of rats following the exposure of experimental for 50days. The biochemical analysis showed a considerable increase the LDSE in the ethanol group as compared to that of control group whereas, decreased in 10% DF+20% ethanol group as compared to that of ethanol group. In addition, the DF supplementation diet restored the ethanol-induced MDA and ADS towards to control. The hepatoprotection of DF is further substantiated by the almost normal histologic findings of liver in 10% DF+20% ethanol group against degenerative changes in ethanol group. The results indicated that the DF could be as important as diet-derived antioxidants and antihepatotoxicity in preventing oxidative damage in the tissues by inhibiting the production of ethanol-induced free radicals and hepatotoxicity in rats.

  15. Hepatoprotective and toxicological studies of Salvia bucharica methanolic extract in rabbits.

    PubMed

    Ahmad, Mansoor; Muhammed, Shafi; Mehjabeen, -; Jahan, Noor

    2014-11-01

    Most of the species of genus Salvia are famous for having medicinal properties due to their chemical constituents. Salvia bucharica (Lamiacea) is found in Balochistan near Quetta in Hannaurak and Kalat. It is used in traditional system of medicine and claims to cure liver ailments. In current study crude methanolic extract (CME) of Salvia bucharica was obtained from the leaves and tested for hepatoprotective activity and possible toxicity in rabbits. Liver toxicity was induced in rabbits by administration of carbon tetra chloride (CCl4) and evaluated by biochemical tests and histopathology of tissues. In this study rabbits were divided in to 3 groups (5 rabbit in each group). Rabbits of group I (control) were administered only vehicle (0.9% sodium chloride) orally. Rabbits of group II were given CCl4 and group III were treated with CCl4 and S. bucharica CME orally. For hepatoprotective effect serum enzyme level and total protein level were calculated. Histopathology of liver sections of rabbits was also carried out to observe protective effect. Biochemical, hematological and histoptahological parameters were studied on rabbits for toxicological studies. S. bucharica CME showed significant liver protection with reduction in total bilirubin, direct bilirubin, Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP), gamma glutamyl transpeptidase (γ-GT). And decrease in Albumin and globulin. In toxicological studies, biochemical and histoptahological parameters showed no significant toxicity in liver, heart and kidneys. It is concluded that S. bucharica CME showed hepatoprotective effects with nontoxic profile.

  16. Evaluation of Missed Energy Saving Opportunity Based on Illinois Home Performance Program Field Data: Homeowner Selected Upgrades vs. Cost-Optimized Solutions; Chicago, Illinois (Fact Sheet)

    SciTech Connect

    Not Available

    2014-07-01

    Expanding on previous research by PARR, this study compares measure packages installed during 800 Illinois Home Performance with ENERGY STAR (IHP) residential retrofits to those recommended as cost-optimal by Building Energy Optimization (BEopt) modeling software. In previous research, cost-optimal measure packages were identified for fifteen Chicagoland single family housing archetypes, called housing groups. In the present study, 800 IHP homes are first matched to one of these fifteen housing groups, and then the average measures being installed in each housing group are modeled using BEopt to estimate energy savings. For most housing groups, the differences between recommended and installed measure packages is substantial. By comparing actual IHP retrofit measures to BEopt-recommended cost-optimal measures, missed savings opportunities are identified in some housing groups; also, valuable information is obtained regarding housing groups where IHP achieves greater savings than BEopt-modeled, cost-optimal recommendations. Additionally, a measure-level sensitivity analysis conducted for one housing group reveals which measures may be contributing the most to gas and electric savings. Overall, the study finds not only that for some housing groups, the average IHP retrofit results in more energy savings than would result from cost-optimal, BEopt-recommended measure packages, but also that linking home categorization to standardized retrofit measure packages provides an opportunity to streamline the process for single family home energy retrofits and maximize both energy savings and cost-effectiveness.

  17. Effects of a behaviour change intervention for Girl Scouts on child and parent energy-saving behaviours

    NASA Astrophysics Data System (ADS)

    Boudet, Hilary; Ardoin, Nicole M.; Flora, June; Armel, K. Carrie; Desai, Manisha; Robinson, Thomas N.

    2016-08-01

    Energy education programmes for children are hypothesized to have great potential to save energy. Such interventions are often assumed to impact child and family behaviours. Here, using a cluster-randomized controlled trial with 30 Girl Scout troops in Northern California, we assess the efficacy of two social cognitive theory-based interventions focused on residential and food-and-transportation energy-related behaviours of Girl Scouts and their families. We show that Girl Scouts and parents in troops randomly assigned to the residential energy intervention significantly increased their self-reported residential energy-saving behaviours immediately following the intervention and after more than seven months of follow-up, compared with controls. Girl Scouts in troops randomly assigned to the food-and-transportation energy intervention significantly increased their self-reported food-and-transportation energy-saving behaviours immediately following the intervention, compared with controls, but not at follow-up. The results demonstrate that theory-based, child-focused energy interventions have the potential to increase energy-saving behaviours among both children and their parents.

  18. All-solid-state electrochromic device integrated with near-IR blocking layer for image sensor and energy-saving glass application

    NASA Astrophysics Data System (ADS)

    Wang, Min-Chuan; Hsieh, Ming-Hao; Chen, Yung-Chih; Wang, Jen-Yuan

    2016-09-01

    The all-solid-state electrochromic device (ECD) integrated with near-IR (NIR) blocking layer fabricated by reactive DC magnetron sputtering technique has been developed for image sensor and energy-saving glass applications. The all-solid-state ECD with the single-substrate structure of glass/NIR-blocking transparent conductive oxide (TCO)/NiO/Ta2O5/WO3/ITO could potentially modulate the optical transmittance between 81.9% and 17.5% at 550 nm in the visible region and between 38.0% and 9.5% at the NIR wavelength larger than 1100 nm. The better energy-saving and light blocking performance, including the larger optical density difference (ΔOD) and lower solar heat-gain coefficient (SHGC) could be achieved in the NIR-blocking ECD structure, even with the general criteria SHGC(bleach)/SHGC(colored) < 3. With the application of ECDs, it is possible to directly apply the device onto an image sensor and energy-saving glass with the NIR rejection function even in the bleached state. Furthermore, the NIR-blocking TCO with the low sheet resistance and high transparency characteristics also provides the lower power consumption in the switching cycle at voltages as low as 5 V, and makes ECDs the ideal components for applications of large area and battery powered devices.

  19. Analyzing the effect of the longwave emissivity and solar reflectance of building envelopes on energy-saving in buildings in various climates

    SciTech Connect

    Shi, Zhiyang; Zhang, Xiong

    2011-01-15

    A dynamic computer simulation is carried out in the climates of 35 cities distributed around the world. The variation of the annual air-conditioning energy loads due to changes in the longwave emissivity and the solar reflectance of the building envelopes is studied to find the most appropriate exterior building finishes in various climates (including a tropical climate, a subtropical climate, a mountain plateau climate, a frigid-temperate climate and a temperate climate). Both the longwave emissivity and the solar reflectance are set from 0.1 to 0.9 with an interval of 0.1 in the simulation. The annual air-conditioning energy loads trends of each city are listed in a chart. The results show that both the longwave emissivity and the solar reflectance of building envelopes play significant roles in energy-saving for buildings. In tropical climates, the optical parameters of the building exterior surface affect the building energy-saving most significantly. In the mountain plateau climates and the subarctic climates, the impacts on energy-saving in buildings due to changes in the longwave emissivity and the solar reflectance are still considerable, but in the temperate continental climates and the temperate maritime climates, only limited effects are seen. (author)

  20. Energy efficiency by use of automated energy-saving windows with heat-reflective screens and solar battery for power supply systems of European and Russian buildings

    NASA Astrophysics Data System (ADS)

    Zakharov, V. M.; Smirnov, N. N.; Tyutikov, V. V.; Flament, B.

    2015-10-01

    The new energy saving windows with heat-reflecting shields have been developed, and for their practical use they need to be integrated into the automated system for controlling heat supply in buildings and the efficiency of their use together with the existing energy-saving measures must be determined. The study was based on the results of field tests of windows with heat-reflective shields in a certified climate chamber. The method to determine the minimum indoor air temperature under standby heating using heat-reflective shields in the windows and multifunctional energy-efficient shutter with solar battery have been developed. Annual energy saving for the conditions of different regions of Russia and France was determined. Using windows with heat-reflecting screens and a solar battery results in a triple power effect: reduced heat losses during the heating season due to increased window resistance; lower cost of heating buildings due to lowering of indoor ambient temperature; also electric power generation.

  1. Evaluation of Missed Energy Saving Opportunity Based on Illinois Home Performance Program Field Data: Homeowner Selected Upgrades Versus Cost-Optimized Solutions

    SciTech Connect

    Yee, S.; Milby, M.; Baker, J.

    2014-06-01

    Expanding on previous research by PARR, this study compares measure packages installed during 800 Illinois Home Performance with ENERGY STAR(R) (IHP) residential retrofits to those recommended as cost-optimal by Building Energy Optimization (BEopt) modeling software. In previous research, cost-optimal measure packages were identified for fifteen Chicagoland single family housing archetypes, called housing groups. In the present study, 800 IHP homes are first matched to one of these fifteen housing groups, and then the average measures being installed in each housing group are modeled using BEopt to estimate energy savings. For most housing groups, the differences between recommended and installed measure packages is substantial. By comparing actual IHP retrofit measures to BEopt-recommended cost-optimal measures, missed savings opportunities are identified in some housing groups; also, valuable information is obtained regarding housing groups where IHP achieves greater savings than BEopt-modeled, cost-optimal recommendations. Additionally, a measure-level sensitivity analysis conducted for one housing group reveals which measures may be contributing the most to gas and electric savings. Overall, the study finds not only that for some housing groups, the average IHP retrofit results in more energy savings than would result from cost-optimal, BEopt recommended measure packages, but also that linking home categorization to standardized retrofit measure packages provides an opportunity to streamline the process for single family home energy retrofits and maximize both energy savings and cost-effectiveness.

  2. Evaluation of Missed Energy Saving Opportunity Based on Illinois Home Performance Program Field Data: Homeowner Selected Upgrades Versus Cost-Optimized Solutions

    SciTech Connect

    Yee, S.; Milby, M.; Baker, J.

    2014-06-01

    Expanding on previous research by PARR, this study compares measure packages installed during 800 Illinois Home Performance with ENERGY STAR® (IHP) residential retrofits to those recommended as cost-optimal by Building Energy Optimization (BEopt) modeling software. In previous research, cost-optimal measure packages were identified for 15 Chicagoland single family housing archetypes. In the present study, 800 IHP homes are first matched to one of these 15 housing groups, and then the average measures being installed in each housing group are modeled using BEopt to estimate energy savings. For most housing groups, the differences between recommended and installed measure packages is substantial. By comparing actual IHP retrofit measures to BEopt-recommended cost-optimal measures, missed savings opportunities are identified in some housing groups; also, valuable information is obtained regarding housing groups where IHP achieves greater savings than BEopt-modeled, cost-optimal recommendations. Additionally, a measure-level sensitivity analysis conducted for one housing group reveals which measures may be contributing the most to gas and electric savings. Overall, the study finds not only that for some housing groups, the average IHP retrofit results in more energy savings than would result from cost-optimal, BEopt recommended measure packages, but also that linking home categorization to standardized retrofit measure packages provides an opportunity to streamline the process for single family home energy retrofits and maximize both energy savings and cost effectiveness.

  3. Assessment of Energy Savings Potential from the Use of Demand Control Ventilation Systems in General Office Spaces in California

    SciTech Connect

    Hong, Tianzhen; Fisk, William J.

    2009-07-08

    Demand controlled ventilation (DCV) was evaluated for general office spaces in California. A medium size office building meeting the prescriptive requirements of the 2008 California building energy efficiency standards (CEC 2008) was assumed in the building energy simulations performed with the EnergyPlus program to calculate the DCV energy savings potential in five typical California climates. Three design occupancy densities and two minimum ventilation rates were used as model inputs to cover a broader range of design variations. The assumed values of minimum ventilation rates in offices without DCV, based on two different measurement methods, were 81 and 28 cfm per occupant. These rates are based on the co-author's unpublished analyses of data from EPA's survey of 100 U.S. office buildings. These minimum ventilation rates exceed the 15 to 20 cfm per person required in most ventilation standards for offices. The cost effectiveness of applying DCV in general office spaces was estimated via a life cycle cost analyses that considered system costs and energy cost reductions. The results of the energy modeling indicate that the energy savings potential of DCV is largest in the desert area of California (climate zone 14), followed by Mountains (climate zone 16), Central Valley (climate zone 12), North Coast (climate zone 3), and South Coast (climate zone 6). The results of the life cycle cost analysis show DCV is cost effective for office spaces if the typical minimum ventilation rates without DCV is 81 cfm per person, except at the low design occupancy of 10 people per 1000 ft{sup 2} in climate zones 3 and 6. At the low design occupancy of 10 people per 1000 ft{sup 2}, the greatest DCV life cycle cost savings is a net present value (NPV) of $0.52/ft{sup 2} in climate zone 14, followed by $0.32/ft{sup 2} in climate zone 16 and $0.19/ft{sup 2} in climate zone 12. At the medium design occupancy of 15 people per 1000 ft{sup 2}, the DCV savings are higher with a NPV $0

  4. Assessment of Energy Savings Potential from the Use of Demand Controlled Ventilation in General Office Spaces in California

    SciTech Connect

    Hong, Tianzhen; Fisk, William

    2010-01-01

    A prototypical office building meeting the prescriptive requirements of the 2008 California building energy efficiency standards (Title 24) was used in EnergyPlus simulations to calculate the energy savings potential of demand controlled ventilation (DCV) in five typical California climates per three design occupancy densities and two minimum ventilation rates. The assumed minimum ventilation rates in offices without DCV, based on two different measurement methods employed in a large survey, were 38 and 13 L/s per occupant. The results of the life cycle cost analysis show DCV is cost effective for office spaces if the typical minimum ventilation rate without DCV is 38 L/s per person, except at the low design occupancy of 10.8 people per 100 m2 in climate zones 3 (north coast) and 6 (south Coast). DCV was not found to be cost effective if the typical minimum ventilation rate without DCV is 13 L/s per occupant, except at high design occupancy of 21.5 people per 100 m2 in climate zones 14 (desert) and 16 (mountains). Until the large uncertainties about the base case ventilation rates in offices without DCV are reduced, the case for requiring DCV in general office spaces will be a weak case. Under the Title 24 Standards office occupant density of 10.8 people per 100 m2, DCV becomes cost effective when the base case minimum ventilation rate is greater than 42.5, 43.0, 24.0, 19.0, and 18.0 L/s per person for climate zone 3, 6, 12, 14, and 16 respectively.

  5. Analysis of Potential Energy Saving and CO2 Emission Reduction of Home Appliances and Commercial Equipments in China

    SciTech Connect

    Zhou, Nan; Fridley, David; McNeill, Michael; Zheng, Nina; Letschert, Virginie; Ke, Jing; Saheb, Yamina

    2010-06-07

    China is now the world's largest producer and consumer of household appliances and commercial equipment. To address the growth of electricity use of the appliances, China has implemented a series of minimum energy performance standards (MEPS) for 30 appliances, and voluntary energy efficiency label for 40 products. Further, in 2005, China started a mandatory energy information label that covers 19 products to date. However, the impact of these standard and labeling programs and their savings potential has not been evaluated on a consistent basis. This research involved modeling to estimate the energy saving and CO{sub 2} emission reduction potential of the appliances standard and labeling program for products for which standards are currently in place, or under development and those proposed for development in 2010. Two scenarios that have been developed differ primarily in the pace and stringency of MEPS development. The 'Continued Improvement Scenario' (CIS) reflects the likely pace of post-2009 MEPS revisions, and the likely improvement at each revision step considering the technical limitation of the technology. The 'Best Practice Scenario' (BPS) examined the potential of an achievement of international best practice MEPS in 2014. This paper concludes that under the 'CIS' of regularly scheduled MEPS revisions to 2030, cumulative electricity consumption could be reduced by 9503 TWh, and annual CO{sub 2} emissions would be 16% lower than in the frozen efficiency scenario. Under a 'BPS' scenario for a subset of products, cumulative electricity savings would be 5450 TWh and annual CO{sub 2} emissions reduction would be 35% lower than in the frozen scenario.

  6. In Vitro Bioaccessibility, Human Gut Microbiota Metabolites and Hepatoprotective Potential of Chebulic Ellagitannins: A Case of Padma Hepaten® Formulation

    PubMed Central

    Olennikov, Daniil N.; Kashchenko, Nina I.; Chirikova, Nadezhda K.

    2015-01-01

    Chebulic ellagitannins (ChET) are plant-derived polyphenols containing chebulic acid subunits, possessing a wide spectrum of biological activities that might contribute to health benefits in humans. The herbal formulation Padma Hepaten containing ChETs as the main phenolics, is used as a hepatoprotective remedy. In the present study, an in vitro dynamic model simulating gastrointestinal digestion, including dialysability, was applied to estimate the bioaccessibility of the main phenolics of Padma Hepaten. Results indicated that phenolic release was mainly achieved during the gastric phase (recovery 59.38%–97.04%), with a slight further release during intestinal digestion. Dialysis experiments showed that dialysable phenolics were 64.11% and 22.93%–26.05% of their native concentrations, respectively, for gallic acid/simple gallate esters and ellagitanins/ellagic acid, in contrast to 20.67% and 28.37%–55.35% for the same groups in the non-dialyzed part of the intestinal media. Investigation of human gut microbiota metabolites of Padma Hepaten and pure ChETs (chebulinic, chebulagic acids) established the formation of bioactive urolithins (A, B, C, D, M5). The fact of urolithin formation during microbial transformation from ChETs and ChET-containing plant material was revealed for the first time. Evaluation of the protective effect of ChETs colonic metabolites and urolithins on tert-butyl hydroperoxide (t-BHP)-induced oxidative injury in cultured rat primary hepatocytes demonstrated their significant reversion of the t-BHP-induced cell cytotoxicity, malonic dialdehyde production and lactate dehydrogenase leakage. The most potent compound was urolithin C with close values of hepatoprotection to gallic acid. The data obtained indicate that in the case of Padma Hepaten, we speculate that urolithins have the potential to play a role in the hepatic prevention against oxidative damage. PMID:26473917

  7. In Vitro Bioaccessibility, Human Gut Microbiota Metabolites and Hepatoprotective Potential of Chebulic Ellagitannins: A Case of Padma Hepaten® Formulation.

    PubMed

    Olennikov, Daniil N; Kashchenko, Nina I; Chirikova, Nadezhda K

    2015-10-13

    Chebulic ellagitannins (ChET) are plant-derived polyphenols containing chebulic acid subunits, possessing a wide spectrum of biological activities that might contribute to health benefits in humans. The herbal formulation Padma Hepaten containing ChETs as the main phenolics, is used as a hepatoprotective remedy. In the present study, an in vitro dynamic model simulating gastrointestinal digestion, including dialysability, was applied to estimate the bioaccessibility of the main phenolics of Padma Hepaten. Results indicated that phenolic release was mainly achieved during the gastric phase (recovery 59.38%-97.04%), with a slight further release during intestinal digestion. Dialysis experiments showed that dialysable phenolics were 64.11% and 22.93%-26.05% of their native concentrations, respectively, for gallic acid/simple gallate esters and ellagitanins/ellagic acid, in contrast to 20.67% and 28.37%-55.35% for the same groups in the non-dialyzed part of the intestinal media. Investigation of human gut microbiota metabolites of Padma Hepaten and pure ChETs (chebulinic, chebulagic acids) established the formation of bioactive urolithins (A, B, C, D, M5). The fact of urolithin formation during microbial transformation from ChETs and ChET-containing plant material was revealed for the first time. Evaluation of the protective effect of ChETs colonic metabolites and urolithins on tert-butyl hydroperoxide (t-BHP)-induced oxidative injury in cultured rat primary hepatocytes demonstrated their significant reversion of the t-BHP-induced cell cytotoxicity, malonic dialdehyde production and lactate dehydrogenase leakage. The most potent compound was urolithin C with close values of hepatoprotection to gallic acid. The data obtained indicate that in the case of Padma Hepaten, we speculate that urolithins have the potential to play a role in the hepatic prevention against oxidative damage.

  8. High rising energy savings

    SciTech Connect

    Not Available

    1985-03-01

    In an effort to demonstrate that cost effective energy innovation is found in the synergistic combination of many basic proven architectural, mechanical and electrical elements, a team of consultants, architects and engineers joined together on a project: Galleria One in Atlanta, Georgia. They started with an efficient envelope and excellent individual floor VAV air conditioning systems. They reduced and eliminated heat gains. A Value and Energy Engineering checklist was created and is presented in this paper. There was no additional annual operation and maintenance cost incurred by the energy conserving features of the project with the exception of an emergency generator, which runs approximately 100 hours each summer and thus requires some additional maintenance.

  9. Energy saving thermostat

    SciTech Connect

    Fodera, A.W.

    1983-09-13

    A thermostat device is disclosed for motels/hotels requiring the guest to use a key to select a desired room temperature which in turn requires that the thermostat must be set back to a preset temperature when guest desires to lock the door to his motel/hotel room upon leaving the room.

  10. Energy saving exhaust siphon

    SciTech Connect

    Baldwin, N.B.

    1982-04-06

    A device is disclosed for attachment to the tailpipe of an exhaust system comprising a body portion placed around the tailpipe, but spaced apart from the tailpipe, in a manner that air may easily flow between the body portion and the tailpipe when the vehicle is moving in a forward direction, a narrowing portion operative to compress the air flow, and an exhaust discharge portion operative for the exhaust from the tailpipe and the air to be discharged therethrough.

  11. Brewing energy savings, too

    SciTech Connect

    Not Available

    1985-03-01

    Lizardos Engineering Associates, P.C. evaluated existing utilities for the Stroh Brewery Company in preparation for the installation of three new double-deck beverage container pasteurizers at the Legigh Valley Brewery in Allentown, Pennsyvania. Meeting the criteria for a conventional installation requires an increase of 1.2 million gallons of potable water daily. A preliminary analysis of the brewery uncovered severe restrictions in incoming potable water use. Lizardos provided engineering design and contract documents for the installation. Several unique applications of existing installation techniques were used and are described in this paper. The system exceeded expectations by not only meeting all the packaging and technical needs of the client, but by also having the capability for the future introduction of a fourth pasteurizer, should marketing demands increase.

  12. Thermostatistics: Proven Energy Savings.

    ERIC Educational Resources Information Center

    Kwasnoski, John

    1983-01-01

    An apparatus simulating residential thermostat control was developed to test claim that lowering house thermostats saves energy and to give students a better understanding of how thermostats work. The apparatus (includes diagram of same) and student activity are described. (JN)

  13. NREL's Energy-Saving Technology for Air Conditioning Cuts Peak Power Loads Without Using Harmful Refrigerants (Fact Sheet)

    SciTech Connect

    Not Available

    2012-07-01

    This fact sheet describes how the DEVAP air conditioner was invented, explains how the technology works, and why it won an R&D 100 Award. Desiccant-enhanced evaporative (DEVAP) air-conditioning will provide superior comfort for commercial buildings in any climate at a small fraction of the electricity costs of conventional air-conditioning equipment, releasing far less carbon dioxide and cutting costly peak electrical demand by an estimated 80%. Air conditioning currently consumes about 15% of the electricity generated in the United States and is a major contributor to peak electrical demand on hot summer days, which can lead to escalating power costs, brownouts, and rolling blackouts. DEVAP employs an innovative combination of air-cooling technologies to reduce energy use by up to 81%. DEVAP also shifts most of the energy needs to thermal energy sources, reducing annual electricity use by up to 90%. In doing so, DEVAP is estimated to cut peak electrical demand by nearly 80% in all climates. Widespread use of this cooling cycle would dramatically cut peak electrical loads throughout the country, saving billions of dollars in investments and operating costs for our nation's electrical utilities. Water is already used as a refrigerant in evaporative coolers, a common and widely used energy-saving technology for arid regions. The technology cools incoming hot, dry air by evaporating water into it. The energy absorbed by the water as it evaporates, known as the latent heat of vaporization, cools the air while humidifying it. However, evaporative coolers only function when the air is dry, and they deliver humid air that can lower the comfort level for building occupants. And even many dry climates like Phoenix, Arizona, have a humid season when evaporative cooling won't work well. DEVAP extends the applicability of evaporative cooling by first using a liquid desiccant-a water-absorbing material-to dry the air. The dry air is then passed to an indirect evaporative

  14. Hepatoprotective Effect and Synergism of Bisdemethoycurcumin against MCD Diet-Induced Nonalcoholic Fatty Liver Disease in Mice

    PubMed Central

    Lee, Young-Seob; Han, Sin-Hee; Ahn, Young-Sup; Cha, Seon-Woo; Seo, Yun-Soo; Kong, Ryong; Kwon, Dong-Yeul

    2016-01-01

    Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, has become one of the most common causes of chronic liver disease over the last decade in developed countries. NAFLD includes a spectrum of pathological hepatic changes, such as steatosis, steatohepatitis, advanced fibrosis, and cirrhosis. Bisdemethoxycurcumin (BDMC) is polyphenolic compounds with a diarylheptanoid skeleton, curcumin close analogues, which is derived from the Curcumae Longae Rhizoma. While the rich bioavailability research of curcumin, BDMC is the poor studies. We investigated whether BDMC has the hepatoprotective effect and combinatory preventive effect with silymarin on methionine choline deficient (MCD)-diet-induced NAFLD in C57BL/6J mice. C57BL/6J mice were divided into five groups of normal (normal diet without any treatment), MCD diet (MCD diet only), MCD + silymarin (SIL) 100 mg/kg group, MCD + BDMC 100 mg/kg group, MCD + SIL 50 mg/kg + BDMC 50 mg/kg group. Body weight, liver weight, liver function tests, histological changes were assessed and quantitative real-time polymerase chain reaction and Western blot analyses were conducted after 4 weeks. Mice lost body weight on the MCD-diet, but BDMC did not lose less than the MCD-diet group. Liver weights decreased from BDMC, but they increased significantly in the MCD-diet groups. All liver function test values decreased from the MCD-diet, whereas those from the BDMC increased significantly. The MCD- diet induced severe hepatic fatty accumulation, but the fatty change was reduced in the BDMC. The BDMC showed an inhibitory effect on liver lipogenesis by reducing associated gene expression caused by the MCD-diet. In all experiments, the combinations of BDMC with SIL had a synergistic effect against MCD-diet models. In conclusion, our findings indicate that BDMC has a potential suppressive effect on NAFLD. Therefore, our data suggest that BDMC may act as a novel and potent therapeutic agent against NAFLD

  15. Hepatoprotective Effect and Synergism of Bisdemethoycurcumin against MCD Diet-Induced Nonalcoholic Fatty Liver Disease in Mice.

    PubMed

    Kim, Sung-Bae; Kang, Ok-Hwa; Lee, Young-Seob; Han, Sin-Hee; Ahn, Young-Sup; Cha, Seon-Woo; Seo, Yun-Soo; Kong, Ryong; Kwon, Dong-Yeul

    2016-01-01

    Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, has become one of the most common causes of chronic liver disease over the last decade in developed countries. NAFLD includes a spectrum of pathological hepatic changes, such as steatosis, steatohepatitis, advanced fibrosis, and cirrhosis. Bisdemethoxycurcumin (BDMC) is polyphenolic compounds with a diarylheptanoid skeleton, curcumin close analogues, which is derived from the Curcumae Longae Rhizoma. While the rich bioavailability research of curcumin, BDMC is the poor studies. We investigated whether BDMC has the hepatoprotective effect and combinatory preventive effect with silymarin on methionine choline deficient (MCD)-diet-induced NAFLD in C57BL/6J mice. C57BL/6J mice were divided into five groups of normal (normal diet without any treatment), MCD diet (MCD diet only), MCD + silymarin (SIL) 100 mg/kg group, MCD + BDMC 100 mg/kg group, MCD + SIL 50 mg/kg + BDMC 50 mg/kg group. Body weight, liver weight, liver function tests, histological changes were assessed and quantitative real-time polymerase chain reaction and Western blot analyses were conducted after 4 weeks. Mice lost body weight on the MCD-diet, but BDMC did not lose less than the MCD-diet group. Liver weights decreased from BDMC, but they increased significantly in the MCD-diet groups. All liver function test values decreased from the MCD-diet, whereas those from the BDMC increased significantly. The MCD- diet induced severe hepatic fatty accumulation, but the fatty change was reduced in the BDMC. The BDMC showed an inhibitory effect on liver lipogenesis by reducing associated gene expression caused by the MCD-diet. In all experiments, the combinations of BDMC with SIL had a synergistic effect against MCD-diet models. In conclusion, our findings indicate that BDMC has a potential suppressive effect on NAFLD. Therefore, our data suggest that BDMC may act as a novel and potent therapeutic agent against NAFLD

  16. Hepatoprotectant ursodeoxycholyl lysophosphatidylethanolamide increasing phosphatidylcholine levels as a potential therapy of acute liver injury.

    PubMed

    Chamulitrat, Walee; Zhang, Wujuan; Xu, Weihong; Pathil, Anita; Setchell, Kenneth; Stremmel, Wolfgang

    2012-01-01

    It has been long known that hepatic synthesis of phosphatidylcholine (PC) is depressed during acute such as carbon tetrachloride-induced liver injury. Anti-hepatotoxic properties of PC as liposomes have been recognized for treatment of acute liver damage. Ursodeoxycholate (UDCA) is a known hepatoprotectant in stabilizing cellular membrane. For therapeutic management of liver injury, we coupled UDCA with a phospholipid known as ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE). UDCA-LPE has been shown to first-in-class hepatoprotectant being superior to UDCA or PC. It inhibits mitochondrial damage and apoptosis, elicits survival signaling pathway, and promotes regeneration of hepatocytes. We herein report that a unique contribution of UDCA-LPE in increasing concentrations of PC in vitro and in vivo. UDCA-LPE-treated hepatocytes contained significantly increased PC levels. UDCA-LPE underwent the hydrolysis to LPE which was not the precursor of the increased PC. The levels of PC in the liver and blood were increased rapidly after intraperitoneally administration UDCA-LPE, and were found to be sustained even after 24 h. Among PC synthesis genes tested, UDCA-LPE treatment of mouse hepatocytes increased transcription of CDP-diacylglycerol synthase 1 which is an enzyme catalyzing phosphatidic acid to generate intermediates for PC synthesis. Thus, UDCA-LPE as a hepatoprotectant was able to induce synthesis of protective PC which would supplement for the loss of PC occurring during acute liver injury. This property has placed UDCA-LPE as a candidate agent for therapy of acute hepatotoxicity such as acetaminophen poisoning. PMID:22363296

  17. Comparative hepatoprotective effects of tocotrienol analogs against drug-induced liver injury.

    PubMed

    Tan, Cheau Yih; Saw, Tzuen Yih; Fong, Chee Wai; Ho, Han Kiat

    2015-01-01

    Oxidative stress plays a major part in the pathogenesis of drug-induced liver injury. Yet, overcoming it with other xenobiotics impose additional risks. In this study, we consider the use of natural-occurring and purified Vitamin E analogs as hepatoprotective agents. Vitamin E is well-known for its intrinsic antioxidant property even though the differential effect of specific analogs of tocopherol (TP) and tocotrienol (T3) is still not ascertained. This study investigates the protective effect of T3 analogs (α-, δ-, γ-) in comparison with α-TP followed by assessing the underlying mechanisms of the cytoprotective T3 analog(s) in two xenobiotics-induced liver injury models using (1) acetaminophen (APAP)- and (2) hydrogen peroxide (H2O2). Both α-TP and α-T3 exerted cytoprotective effects while only lower concentration of γ-T3 was effective in inhibiting both toxicants induced injury. α-TP/α-T3 protected hepatocytes from APAP and H2O2-induced liver injury through arresting free radicals and inhibiting oxidative stress (inhibition of reactive oxygen species, lipid peroxidation and mitochondrial permeability transition). There was also demonstrable inhibition of the apoptotic pathway (inhibition of caspse-3 activity and overexpression of Bcl-XL), accompanied with an induction of liver regeneration (PCNA and NF-kB). The cellular uptake of α-T3 was higher than α-TP at the same treatment dosage after 24h. Overall, α-T3 seems to be a more potent hepatoprotective analog among the tocotrienols and α-TP at the same in vitro treatment dosage. In summary, these results suggest that α-TP/α-T3 elicit hepatoprotective effects against toxicants-induced damage mainly through activation of antioxidant responses at an early stage to prevent the exacerbation of injury. PMID:25637740

  18. Hepatoprotective and antiviral efficacy of Acacia mellifera leaves fractions against hepatitis B virus.

    PubMed

    Arbab, Ahmed H; Parvez, Mohammad K; Al-Dosari, Mohammed S; Al-Rehaily, Adnan J; Al-Sohaibani, Mohammed; Zaroug, Elwaleed E; AlSaid, Mansour S; Rafatullah, Syed

    2015-01-01

    The present study investigated the hepatoprotective and anti-HBV efficacy of Acacia mellifera (AM) leaves extracts. The crude ethanolic-extract, including organic and aqueous fractions, were tested for cytotoxicity on HepG2 and HepG2.2.15 cells (IC50=684 μg/mL). Of these, the ethyl acetate and aqueous fractions showed the most promising, dose-dependent hepatoprotection in DCFH-toxicated cells at 48 h. In CCl4-injured rats, oral administration of AM ethanol extract (250 and 500 mg/kg·bw) for three weeks significantly normalized the sera aminotransferases, alkaline phosphatase, bilirubin, cholesterol, triglycerides, and lipoprotein levels and elevated tissue nonprotein sulphydryl and total protein. The histopathology of dissected livers also revealed that AM cured the tissue lesions. The phytochemical screening of the fractions showed presence of alkaloids, flavonoids, tannins, sterols, and saponins. Further, anti-HBV potential of the fractions was evaluated on HepG2.2.15 cells. Of these, the n-butanol and aqueous fractions exhibited the best inhibitory effects on HBsAg and HBeAg expressions in dose- and time-dependent manner. Taken together, while the ethyl acetate and aqueous fractions exhibited the most promising antioxidant/hepatoprotective and anti-HBV activity, respectively, the n-butanol partition showed both activities. Therefore, the therapeutic potential of AM extracts warrants further isolation of the active principle(s) and its phytochemical as well as biological studies. PMID:25950002

  19. Hepatoprotective Effect and Chemical Assessment of a Selected Egyptian Chickpea Cultivar

    PubMed Central

    Mekky, Reham H.; Fayed, Mostafa R.; El-Gindi, Mohamed R.; Abdel-Monem, Azza R.; Contreras, María del Mar; Segura-Carretero, Antonio; Abdel-Sattar, Essam

    2016-01-01

    Chickpea (Cicer arietinum) is a legume of the family Fabaceae, subfamily Faboideae. In Egypt, chickpea seeds are usually consumed at raw green and tender stage, or in the form of mature dry seeds. In our previous study, ‘Giza 1’ seeds exhibited stronger antioxidant activity and higher total phenol content than those from other Egyptian cultivars. In order to assess the biological potential of ‘Giza 1’ seeds in vivo, the extraction procedure was reproduced here. The extract was standardized using liquid chromatography coupled to diode array detector and tandem mass spectrometry (MS/MS) to evaluate their hepatoprotective effect on carbon tetrachloride (CCl4)-induced hepatotoxicity in rats and acute toxicity. Administration of the extract to rats in doses up to 2 g/Kg) did not cause any mortalities or observable signs of toxicity. Further, the plant extract showed a strong hepatoprotective activity based on assessing serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase and levels of albumen, globulin, total protein, total cholesterol, high density lipoprotein, triglycerides, and low density lipoprotein. The antioxidative activity was evaluated by assessing hepatic catalase and superoxide dismutase activity as well as reduced glutathione, and malondialdehyde levels. Additionally, anti-inflammatory activity was observed as the extract significantly lowered the hepatic tumor necrosis factor α content. Histopathological examination of liver tissues indicated that the extract-treated animals showed almost normal hepatic architecture with fewer pathological changes. In conclusion, the current results suggest that the chickpea extract possesses an excellent safety profile with very low acute toxicity. Also, it exhibits a significant hepatoprotective effect against CCl4-induced liver injury in rats. This can be attributed, at least partly, to the antioxidant and anti-inflammatory activity of the isoflavones and phenolic acids content

  20. Hepatoprotective and Antiviral Efficacy of Acacia mellifera Leaves Fractions against Hepatitis B Virus

    PubMed Central

    Arbab, Ahmed H.; Parvez, Mohammad K.; Al-Dosari, Mohammed S.; Al-Rehaily, Adnan J.; Al-Sohaibani, Mohammed; Zaroug, Elwaleed E.; AlSaid, Mansour S.; Rafatullah, Syed

    2015-01-01

    The present study investigated the hepatoprotective and anti-HBV efficacy of Acacia mellifera (AM) leaves extracts. The crude ethanolic-extract, including organic and aqueous fractions, were tested for cytotoxicity on HepG2 and HepG2.2.15 cells (IC50 = 684 μg/mL). Of these, the ethyl acetate and aqueous fractions showed the most promising, dose-dependent hepatoprotection in DCFH-toxicated cells at 48 h. In CCl4-injured rats, oral administration of AM ethanol extract (250 and 500 mg/kg·bw) for three weeks significantly normalized the sera aminotransferases, alkaline phosphatase, bilirubin, cholesterol, triglycerides, and lipoprotein levels and elevated tissue nonprotein sulphydryl and total protein. The histopathology of dissected livers also revealed that AM cured the tissue lesions. The phytochemical screening of the fractions showed presence of alkaloids, flavonoids, tannins, sterols, and saponins. Further, anti-HBV potential of the fractions was evaluated on HepG2.2.15 cells. Of these, the n-butanol and aqueous fractions exhibited the best inhibitory effects on HBsAg and HBeAg expressions in dose- and time-dependent manner. Taken together, while the ethyl acetate and aqueous fractions exhibited the most promising antioxidant/hepatoprotective and anti-HBV activity, respectively, the n-butanol partition showed both activities. Therefore, the therapeutic potential of AM extracts warrants further isolation of the active principle(s) and its phytochemical as well as biological studies. PMID:25950002

  1. Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats

    PubMed Central

    Cordero-Pérez, Paula; Torres-González, Liliana; Aguirre-Garza, Marcelino; Camara-Lemarroy, Carlos; Guzmán-de la Garza, Francisco; Alarcón-Galván, Gabriela; Zapata-Chavira, Homero; de Jesús Sotelo-Gallegos, Ma.; Nadjedja Torres-Esquivel, Cipactli; Sánchez-Fresno, Ethel; Cantú-Sepúlveda, Daniel; González-Saldivar, Gerardo; Bernal-Ramirez, Judith; E. Muñoz-Espinosa, Linda

    2013-01-01

    Background: Various hepatoprotective herbal products from plants are available in Mexico, where up to 85% of patients with liver disease use some form of complementary and alternative medicine. However, only few studies have reported on the biological evaluation of these products. Objective: Using a model of carbon tetrachloride (CCl4)-induced hepatotoxicity in rats, we evaluated the effects of commercial herbal extracts used most commonly in the metropolitan area of Monterrey, Mexico. Materials and Methods: The commercial products were identified through surveys in public areas. The effect of these products given with or without CCl4 in rats was evaluated by measuring the serum concentrations of aspartate amino transferase (AST) and alanine amino transferase (ALT), and histopathological analysis. Legalon® was used as the standard drug. Results: The most commonly used herbal products were Hepatisan® capsules, Boldo capsules, Hepavida® capsules, Boldo infusion, and milk thistle herbal supplement (80% silymarin). None of the products tested was hepatotoxic according to transaminase and histological analyses. AST and ALT activities were significantly lower in the Hepavida+CCl4-treated group as compared with the CCl4-only group. AST and ALT activities in the silymarin, Hepatisan, and Boldo tea groups were similar to those in the CCl4 group. The CCl4 group displayed submassive confluent necrosis and mixed inflammatory infiltration. Both the Hepatisan+CCl4 and Boldo tea+CCl4 groups exhibited ballooning degeneration, inflammatory infiltration, and lytic necrosis. The silymarin+CCl4 group exhibited microvesicular steatosis. The Hepavida+CCl4- and Legalon+CCL4-treated groups had lower percentages of necrotic cells as compared with the CCl4-treated group; this treatment was hepatoprotective against necrosis. Conclusion: Only Hepavida had a hepatoprotective effect. PMID:23900881

  2. Flavonoid profiles of three Bupleurum species and in vitro hepatoprotective of activity Bupleurum flavum Forsk.

    PubMed Central

    Gevrenova, Reneta; Kondeva-Burdina, Magdalena; Denkov, Nikolay; Zheleva-Dimitrova, Dimitrina

    2015-01-01

    Background: Bupleurum L. (Aspiaceae) species are used as herbal remedy in Chinese traditional medicine. Objective: The aim was to investigate the flavonoids in three annual European Bupleurum species, including B. baldense, B. affine and B. flavum, and to test their antioxidant and possible hepatoprotective effects. Materials and Methods: Flavonoids from the methanol-aqueous extracts were quantified by solid-phase extraction-high-performance liquid chromatography. Bupleurum extracts (1–220 mg/ml) were tested for their antioxidant activity in DPPH and ABTS assays, as well as on isolated liver rat microsomes. In vitro hepatoprotective activity of B. flavum flavonoid (BFF) mixture and rutin, and narcissin, isolated from the same mixture, were evaluated on carbon tetrachloride (CCl4) and tert-butyl hydroperoxide (t-BuOOH) toxicity models in isolated rat hepatocytes. Results: Narcissin was the dominant flavonol glycoside in B. flavum being present at 24.21 ± 0.19 mg/g, whilst the highest content of rutin (28.63 ± 1.57 mg/g) was found in B. baldense. B. flavum possessed the strongest DPPH (IC50 22.12 μg/ml) and ABTS (IC50 118.15 μg/ml) activity. At a concentration 1 mg/ml of BFF (rutin 197.58 mg/g, narcissin 75.74 mg/g), a stronger antioxidant effect in microsomes was evidenced in comparison with silymarin, rutin and narcissin. The hepatoprotective effect of BFF significantly reduced the elevated levels of lactate dehydrogenase and malondialdehyde, and ameliorated glutathione, being most active in t-BuOOH-induced injury model when compared with CCl4 toxicity (P < 0.001). Conclusion: In BFF, synergism of rutin and narcissin could be responsible for stronger protection against mitochondrial induced oxidative stress. PMID:25709205

  3. Enhancement of absorption and hepatoprotective potential through soya-phosphatidylcholine-andrographolide vesicular system.

    PubMed

    Jain, Pushpendra Kumar; Khurana, Navneet; Pounikar, Yogesh; Gajbhiye, Asmita; Kharya, Murli Dhar

    2013-06-01

    Andrographis paniculata is a medicinal herb used extensively for various ailments and contains therapeutically active phytoconstituent, andrographolide (AN). Although hepatoprotective activity of AN is established, but their bioavailability is restricted due to its rapid clearance. The aim of this study, therefore, was to formulate AN herbosomes (ANH) through complexation with naturally occurring soya-phosphatidylcholine (SPC), in order to enhance absorption. Prepared andrographolide-soy phosphatidylcholine (AN-SPC) complex prepared was subjected for characterisation of complex and formation of vesicular system known as ANH using rotary evaporation techniques. This complex was subjected to in vitro study using everted small intestine sac technique which showed significantly increased absorption of AN from the ANH as compared to the plain AN. The hepatoprotective potential of ANH and plain AN was evaluated using carbon tetrachloride inducing hepatotoxicity rat model and compared, in which ANH equivalent to 50 mg/kg of plain AN significantly restore serum glutamate oxalacetate transaminase (112.4 ± 9.67 for AN whereas 90.2 ± 4.23 for ANH) and serum glutamate pyruvate transaminase (109.3 ± 7.89 for AN whereas 90.6 ± 4.34 for ANH) level as compared to control group. The ANH showed significantly better absorption than plain AN and this effect of ANH was also comparable to the standard drug (Silymarin). The findings of present study reveal that ANH has better bioavailability as shown by in vitro absorption study and hence improved hepatoprotection as compared to plain AN at equivalent dose.

  4. The National Fuel End-Use Efficiency Field Test: Energy Savings and Performance of an Improved Energy Conservation Measure Selection Technique

    SciTech Connect

    Ternes, M.P.

    1991-01-01

    The performance of an advanced residential energy conservation measure (ECM) selection technique was tested in Buffalo, New York, to verify the energy savings and program improvements achieved from use of the technique in conservation programs and provide input into determining whether utility investments in residential gas end-use conservation are cost effective. The technique analyzes a house to identify all ECMs that are cost effective in the building envelope, space-heating system, and water-heating system. The benefit-to-cost ratio (BCR) for each ECM is determined and cost-effective ECMs (BCR > 1.0) are selected once interactions between ECMs are taken into account. Eighty-nine houses with the following characteristics were monitored for the duration of the field test: occupants were low-income, houses were single-family detached houses but not mobile homes, and primary space- and water-heating systems were gas-fired. Forty-five houses received a mix of ECMs as selected by the measure selection technique (audit houses) and 44 served as a control group. Pre-weatherization data were collected from January to April 1988 and post-weatherization data were collected from December 1988 to April 1989. Space- and waterheating gas consumption and indoor temperature were monitored weekly during the two winters. A house energy consumption model and regression analysis were employed to normalize the space-heating energy savings to average outdoor temperature conditions and a 68 F indoor temperature. Space and water-heating energy savings for the audit houses were adjusted by the savings for the control houses. The average savings of 257 therms/year for the audit houses was 17% of the average pre-weatherization house gas consumption and 78% of that predicted. Average space-heating energy savings was 252 therms/year (25% of pre-weatherization space-heating energy consumption and 85% of the predicted value) and average water-heating savings was 5 therms/year (2% of pre

  5. Development, Characterization, and Evaluation of Hepatoprotective Effect of Abutilon indicum and Piper longum Phytosomes

    PubMed Central

    Sharma, Sonam; Sahu, Alakh Niranjan

    2016-01-01

    Background: Evidences from ethnopharmacological practices have shown that combination of Abutilon indicum and Piper longum are traditionally used to treat symptoms of the liver disorder. The hypothesis is phytosomes of a combination of both crude drug extract will be more effective and safe as hepatoprotective agent. Aim: Present work is aimed at development and characterization of phytosomes containing ethanolic extract of both drugs to meet the need for better effectiveness and safety. Materials and Methods: Phytosomes were formulated by using Indena's patented process. Characterization involved following parameters: Particle size determination, percentage yield, entrapment efficiency, differential scanning calorimetry, scanning electron microscope, fourier transform infrared spectroscopy, and high performance thin liquid chromatography. Liver damage was induced in adult Charles foster rats (150 ± 10 g) with CCl4 in olive oil (1:1 v/v, i.p) 1 ml/kg once daily for 7 days. LIV 52 (1 ml/kg per oral [p.o]), ethanolic extract of A. indicum and P. longum combination (100, 200, and 400 mg/kg p.o) and phytosomes (100 mg/kg p.o.) was given 3 days prior to CCl4 administration. Estimation of liver marker enzymes and histopathological studies were done. Result was analyzed by using (analysis of variance) followed by Student-Newman–Keuls test. Result: Combined extract has shown hepatoprotective activity but phytosomal formulation has more potent hepatoprotective effect on CCl4 induced liver toxicity at very low dose comparative to a higher dose of combined extract. Conclusion: Novel approach for herbal drug delivery is more prominent than conventional which improves bioavailability of polar extract and also patient compliance. SUMMARY Standardised ethanolic extract of leaves of abutilon indicum and piper longum fruits by microwave assisted extraction was used for phytosomal complex formation and phytosomal complex was characterised by various parameters and finally the

  6. Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats.

    PubMed

    Yang, Lan; Wang, Cheng-zhang; Ye, Jian-zhong; Li, Hai-tao

    2011-09-01

    The hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves were evaluated against carbon tetrachloride induced hepatic damage in Sprague-Dawley rats. The elevated levels of serum ALT, AST, ALP, ALB, TP, HA, LN, TG, and CHO were restored towards normalization significantly by GBP in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections. Meanwhile, GBP also produced a significant and dose-dependent reversal of CCl(4)-diminished activity of the antioxidant enzymes and reduced CCl(4)-elevated level of MDA. In general, the effects of GBP were not significantly different from those of the standard drug Essentiale.

  7. Current evidence for the hepatoprotective activities of the medicinal mushroom Antrodia cinnamomea

    PubMed Central

    2013-01-01

    Antrodia cinnamomea (AC) is an endemic mushroom species of Taiwan, and has been demonstrated to possess diverse biological and pharmacological activities, such as anti-hypertension, anti-hyperlipidemia, anti-inflammation, anti-oxidation, anti-tumor, and immunomodulation. This review focuses on the inhibitory effects of AC on hepatitis, hepatocarcinoma, and alcohol-induced liver diseases (e.g., fatty liver, fibrosis). The relevant biochemical and molecular mechanisms are addressed. Overall, this review summarizes the hepatoprotective activities in vitro and in vivo. However, there is no doubt that human and clinical trials are still limited, and further studies are required for the development of AC-related products. PMID:24180549

  8. Potential for the Use of Energy Savings Performance Contracts to Reduce Energy Consumption and Provide Energy and Cost Savings in Non-Building Applications

    SciTech Connect

    Williams, Charles; Green, Andrew S.; Dahle, Douglas; Barnett, John; Butler, Pat; Kerner, David

    2013-08-01

    The findings of this study indicate that potential exists in non-building applications to save energy and costs. This potential could save billions of federal dollars, reduce reliance on fossil fuels, increase energy independence and security, and reduce greenhouse gas emissions. The Federal Government has nearly twenty years of experience with achieving similar energy cost reductions, and letting the energy costs savings pay for themselves, by applying energy savings performance contracts (ESPC) inits buildings. Currently, the application of ESPCs is limited by statute to federal buildings. This study indicates that ESPCs can be a compatible and effective contracting tool for achieving savings in non-building applications.

  9. Estimate of Cost-Effective Potential for Minimum Efficiency Performance Standards in 13 Major World Economies Energy Savings, Environmental and Financial Impacts

    SciTech Connect

    Letschert, Virginie E.; Bojda, Nicholas; Ke, Jing; McNeil, Michael A.

    2012-07-01

    This study analyzes the financial impacts on consumers of minimum efficiency performance standards (MEPS) for appliances that could be implemented in 13 major economies around the world. We use the Bottom-Up Energy Analysis System (BUENAS), developed at Lawrence Berkeley National Laboratory (LBNL), to analyze various appliance efficiency target levels to estimate the net present value (NPV) of policies designed to provide maximum energy savings while not penalizing consumers financially. These policies constitute what we call the “cost-effective potential” (CEP) scenario. The CEP scenario is designed to answer the question: How high can we raise the efficiency bar in mandatory programs while still saving consumers money?

  10. Duct Leakage Modeling in EnergyPlus and Analysis of Energy Savings from Implementing SAV with InCITeTM

    SciTech Connect

    Wray, Craig; Sherman, Max

    2010-03-01

    This project addressed two significant deficiencies in air-handling systems for large commercial building: duct leakage and duct static pressure reset. Both constitute significant energy reduction opportunities for these buildings. The overall project goal is to bridge the gaps in current duct performance modeling capabilities, and to expand our understanding of air-handling system performance in California large commercial buildings. The purpose of this project is to provide technical support for the implementation of a duct leakage modeling capability in EnergyPlus, to demonstrate the capabilities of the new model, and to carry out analyses of field measurements intended to demonstrate the energy saving potential of the SAV with InCITeTM duct static pressure reset (SPR) technology. A new duct leakage model has been successfully implemented in EnergyPlus, which will enable simulation users to assess the impacts of leakage on whole-building energy use and operation in a coupled manner. This feature also provides a foundation to support code change proposals and compliance analyses related to Title 24 where duct leakage is an issue. Our example simulations continue to show that leaky ducts substantially increase fan power: 10percent upstream and 10percent downstream leakage increases supply fan power 30percent on average compared to a tight duct system (2.5percent upstream and 2.5percent downstream leakage). Much of this increase is related to the upstream leakage rather than to the downstream leakage. This does not mean, however, that downstream leakage is unimportant. Our simulations also demonstrate that ceiling heat transfer is a significant effect that needs to be included when assessing the impacts of duct leakage in large commercial buildings. This is not particularly surprising, given that ?ceiling regain? issues have already been included in residential analyses as long as a decade ago (e.g., ASHRAE Standard 152); mainstream simulation programs that are

  11. Hepatoprotective Effect of Methanol Extracts of Zingiber officinale and Cichorium intybus

    PubMed Central

    Atta, A. H.; Elkoly, T. A.; Mouneir, S. M.; Kamel, Gehan; Alwabel, N. A.; Zaher, Shaimaa

    2010-01-01

    The present work was carried out to investigate the hepatoprotective effect of ginger, chicory and their mixture against carbon tetrachloride intoxication in rats. Carbon tetrachloride treatment significantly elevated the alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma glutamyltransferase activities and the serum triglycerides and cholesterol concentration as compared to control group. It also increased RBCs counts and Hb concentration, total or differential leucocytes counts. However it decreased platelet counts, platelet distribution width, mean platelet volume, platelet larger cell ratio. Methanol extract of ginger (250 and 500 mg/kg) and chicory (250 and 500 mg/kg) given alone or mixed (1:1 wt/wt) significantly restored the carbon tetrachloride-induced alterations in the biochemical and cellular constituents of blood. No toxic symptoms were reported in doses up to 5 g/kg. Alkaloids and/or nitrogenous bases, carbohydrates and/or glycosides, tannins, flavonoids, saponins and unsaturated sterols and/or triterpenes are the main active constituents of their methanol extract. The hepatoprotective effect of ginger and chicory was also confirmed by the histopathological examination of liver tissue. PMID:21694986

  12. Hypolipidemic and hepatoprotective seeds mixture diet rich in omega-3 and omega-6 fatty acids.

    PubMed

    Makni, Mohamed; Fetoui, Hamadi; Garoui, El Mouldi; Gargouri, Nabil K; Jaber, Hazem; Makni, Jamel; Boudawara, Tahia; Zeghal, Najiba

    2010-01-01

    In vitro physicochemical and antioxidant properties of mixture of Flax/Sesame (LS) and Flax/Peanut (LA) and in vivo hypolipidemic, antioxidant and hepatoprotective activities were carried out to ascertain the claim of its utilisation against diseases. The seeds mixture rich in unsaturated fatty acids were prepared with 5/1 ratio of omega-6/omega-3 fatty acids and were orally administered ad libitum to rats by standard diet for 30 days. High cholesterol fed diet rats (CD-chol) exhibited a significant increase in total plasma and liver lipid parameters and atherogenicity and a significant decrease in high-density lipoproteins (HDL) and HDL/TC ratio (HTR). Administration of (LS) or (LA) seeds mixture to hypercholesterolemic rats (MS-LSchol and MS-LAchol groups respectively) significantly ameliorated lipid parameters and showed an increase of PUFAs (ALA and LA) and MUFAs and a decrease of SFAs in plasma and liver of MS-LSchol and MS-LAchol groups. Furthermore, malondialdehyde levels decreased and the efficiency of antioxidant defense system was improved compared to CD-chol group. Liver histological sections showed lipid storage in hepatocytes of CD-chol group and an improvement was noted in both supplemented groups. Our results suggested that seeds mixtures of Flax/Sesame and Flax/Peanut have anti-atherogenic and hepatoprotective effects. PMID:20510326

  13. Hepatoprotective Activity of Elephantopus scaber on Alcohol-Induced Liver Damage in Mice

    PubMed Central

    Ho, Wan Yong; Yeap, Swee Keong; Ho, Chai Ling; Abdul Rahim, Raha; Alitheen, Noorjahan Banu

    2012-01-01

    Elephantopus scaber has been traditionally used as liver tonic. However, the protective effect of E. scaber on ethanol-induced liver damage is still unclear. In this study, we have compared the in vivo hepatoprotective effect of E. scaber with Phyllanthus niruri on the ethanol-induced liver damage in mice. The total phenolic and total flavanoid content of E. scaber ethanol extract were determined in this study. Accelerating serum biochemical profiles (including AST, ALT, ALP, triglyceride, and total bilirubin) associated with fat drop and necrotic body in the liver section were observed in the mice treated with ethanol. Low concentration of E. scaber was able to reduce serum biochemical profiles and the fat accumulation in the liver. Furthermore, high concentration of E. scaber and positive control P. niruri were able to revert the liver damage, which is comparable to the normal control. Added to this, E. scaber did not possess any oral acute toxicity on mice. These results suggest the potential effect of this extract as a hepatoprotective agent towards-ethanol induced liver damage without any oral acute toxicity effect. These activities might be contributed, or at least in part, by its high total phenolic and flavonoid contents. PMID:22973401

  14. Hepatoprotective Potential of Some Local Medicinal Plants against 2-Acetylaminoflourene-Induced Damage in Rat

    PubMed Central

    Adetutu, Adewale; Olorunnisola, Olubukola S.

    2013-01-01

    The in vivo micronucleus assay was used to examine the anticlastogenic effects of crude extracts of Bridelia ferruginea, Vernonia amygdalina, Tridax procumbens, Ocimum gratissimum, and Lawsonia inermis in Wistar albino rats. Extracts of doses of 100 mg/kg body weight were given to rats in five groups for seven consecutive days followed by a single dose of 2-AAF (0.5 mmol/kg body weight). The rats were sacrificed after 24 hours and their bone marrow smears were prepared on glass slides stained with Giemsa. The micronucleated polychromatic erythrocyte cells (mPCEs) were thereafter recorded. The hepatoprotective effects of the plant extracts against 2-AAF-induced liver toxicity in rats were evaluated by monitoring the levels of alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and histopathological analysis. The results of the 2-AAF-induced liver toxicity experiments showed that rats treated with the plant extracts (100 mg/kg) showed a significant decrease in mPCEs as compared with the positive control. The rats treated with the plant extracts did not show any significant change in the concentration of ALP and GGT in comparison with the negative control group whereas the 2-AAF group showed a significant increase (P < 0.05) in these parameters. Some of the leaf extracts also showed protective effects against histopathological alterations. This study suggests that the leaf extracts have hepatoprotective potential, thereby justifying their ethnopharmacological uses. PMID:24163694

  15. Hepatoprotective effect of trimethylgallic acid esters against carbon tetrachloride-induced liver injury in rats.

    PubMed

    Sachdeva, Mamta; Chadha, Renu; Kumar, Anil; Karan, Maninder; Singh, Tejvir; Dhingra, Sameer

    2015-12-01

    Gallic acid and its derivatives are potential therapeutic agents for treating various oxidative stress mediated disorders. In the present study, we investigated the hepatoprotective effects of newly synthesized conjugated trimethylgallic acid (TMGA) esters against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Animals were pre-treated with TMGA esters at their respective doses for 7 days against CCl4-induced hepatotoxicity. The histopathological changes were evaluated to find out degenerative fatty changes including vacuole formation, inflammation and tissue necrosis. Various biomarkers of oxidative stress (lipid peroxidation, glutathione levels, and endogenous antioxidant enzyme activities), liver enzymes (AST and ALT), triacylglycerol and cholesterol were evaluated. Pre-treatment with TMGA esters (MRG, MGG, MSG, and MUG at the dose of 28.71, 30.03, 31.35, 33.62 mg/kg/day), respectively reversed the CCl4-induced liver injury scores (reduced vacuole formation, inflammation and necrosis), biochemical parameters of plasma (increased AST, ALT, TG, and cholesterol), antioxidant enzymes (increased lipid peroxidation and nitrite levels; decreased glutathione levels, superoxide dismutase and catalase activities) in liver tissues and inflammatory surge (serum TNF-α) significantly. The study revealed that TMGA esters exerted hepatoprotective effects in CCl4-induced rats, specifically by modulating oxidative-nitrosative stress and inflammation.

  16. Studies on the antihypertensive, antispasmodic, bronchodilator and hepatoprotective activities of the Carum copticum seed extract.

    PubMed

    Gilani, A H; Jabeen, Q; Ghayur, M N; Janbaz, K H; Akhtar, M S

    2005-04-01

    This study describes the antihypertensive, antispasmodic, bronchodilator and hepatoprotective activities of the aqueous-methanolic extract of Carum copticum Benth. seeds (CSE) to rationalize some of its traditional uses. CSE (3-100 mg/kg) caused a dose-dependent fall in arterial blood pressure in anaesthetized rats. In isolated rabbit aorta and jejunum preparations, CSE (0.1-3.0 mg/ml) caused an inhibitory effect on the K+-induced contractions. The calcium channel blocking (CCB) effect was confirmed when CSE shifted the Ca2+ dose-response curves (DRCs) to right similar to verapamil. In isolated guinea-pig tracheal preparations, it caused inhibition of carbachol and K+-induced bronchoconstriction at 0.1-1.0 mg/ml as well as shifted the dose-response curves (DRCs) of carbachol and histamine to the right with suppression of maximum response suggestive of non-specific bronchodilator effect mediated possibly through CCB. Pretreatment of rats with CSE (500 mg/kg orally for 2 days at 12 h intervals) prevented paracetamol (640 mg/kg) and CCl4 (150 ml/kg)-induced rise in serum alkaline phosphatase (ALP) and aminotransferases (AST and ALT). The same dose of CSE was able to prevent the CCl4-induced prolongation in pentobarbital-induced sleeping time in mice confirming its hepatoprotectivity. These results indicate the presence of calcium antagonist(s) in Carum copticum seeds and thus provides sound mechanistic basis for some of their folkloric uses.

  17. Hepatoprotective and Antioxidant Activity of Dunaliella salina in Paracetamol-induced Acute Toxicity in Rats

    PubMed Central

    Madkour, Fedekar F.; Abdel-Daim, M. M.

    2013-01-01

    Paracetamol has a reasonable safety profile when taken in therapeutic doses. However, it could induce hepatotoxicity and even more severe fatal acute hepatic damage when taken in an overdose. The green alga, Dunaliella salina was investigated for hepatoprotective and antioxidant activity against paracetamol-induced liver damage in rats. Male albino Wistar rats overdosed with paracetamol showed liver damage and oxidative stress as indicated by significantly (P<0.05) increased serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total and direct bilirubin, malondialdehyde, cholesterol and nitric oxide. At the same time, there were decreased activities of serum superoxide dismutase and total antioxidant capacity compared with the control group. Treatment with D. salina methanol extract at doses of 500 and 1000 mg/kg body weight or silymarin could significantly (P<0.05) decrease the liver damage marker enzymes, total and direct bilirubin, malondialdehyde, cholesterol and nitric oxide levels and increase the activities of superoxide dismutase and total antioxidant capacity in serum when compared with paracetamol intoxicated group. Liver histopathology also showed that D. salina reduced the centrilobular necrosis, congestion and inflammatory cell infiltration evoked by paracetamol overdose. These results suggest that D. salina exhibits a potent hepatoprotective effect on paracetamol-induced liver damage in rats, which may be due to both the increase of antioxidant enzymes activity and inhibition of lipid peroxidation. PMID:24591738

  18. Elucidation of the hepatoprotective moiety of 5β-scymnol that suppresses paracetamol toxicity in mice.

    PubMed

    Hodges, Lynn D; Carter, Fiona; Kalafatis, Nicolette; Wright, Paul F A; Macrides, Theodore A

    2016-06-01

    The shark bile alcohol, 5β-scymnol, protects mice from the hepatotoxic effects of paracetamol (APAP) overdose. To elucidate the hepatoprotective structural moiety of scymnol, we compared its effect with that of its analogue and natural bile salt, sodium scymnol sulfate, in a clinically relevant model of APAP-induced toxicity. Exposure of healthy male Swiss mice to a toxic overdose of APAP (350 mg/kg, ip) significantly increased serum hepatocellular enzyme activities, decreased hepatocellular glutathione (GSH) levels, and induced severe centrilobular hepatocellular necrosis. Repeated low-dose scymnol (5 mg/kg/day for 7 days, ip) significantly reduced the extent of APAP-induced hepatotoxicity without preventing GSH depletion. Sodium scymnol sulfate, which lacks the tri-hydroxyl-substituted aliphatic side chain of scymnol, failed to reduce the APAP hepatotoxicity or prevent GSH depletion when tested under the same experimental conditions. We conclude that the tri-hydroxyl-substituted aliphatic side chain is the hepatoprotective structural moiety of 5β-scymnol that suppresses APAP-induced cytotoxicity in mice. PMID:27234873

  19. Hepatoprotective effect of Bacoside-A, a major constituent of Bacopa monniera Linn.

    PubMed

    Sumathi, T; Nongbri, A

    2008-10-01

    Bacoside-A (B-A) was evaluated for its hepatoprotective activity against d-GalN induced liver injury in rats. B-A is a major constituent isolated from the plant Bacopa monniera Linn. B-A (10mg/kg of body weight) was administered orally once daily for 21 days and then d-GalN (300 mg/kg of body weight) was injected on 21st day after final administration of B-A. B-A reduces the elevated levels of serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (gamma-GT), lactate dehydrogenase (LDH), 5'nucleotidase (5'ND). In addition B-A also significantly restored towards normalization of the decreased levels of Vit-C, and Vit-E induced by d-GalN both in liver and plasma. These results suggest that B-A has hepatoprotective effect against d-GalN induced hepatotoxicity in rats.

  20. Hepatoprotective action of celery (Apium graveolens) leaves in acetaminophen-fed freshwater fish (Pangasius sutchi).

    PubMed

    Shivashri, C; Rajarajeshwari, T; Rajasekar, P

    2013-10-01

    Acetaminophen (APAP)-induced liver damage is one of the most common problems among the population. Therefore, the study was aimed to investigate the hepatoprotective effect of celery leaves on APAP-induced toxicity in a freshwater fish, Pangasius sutchi. Fish were divided into four experimental groups of 6 fish each. Group 1 served as control. Group 2 fish were exposed to APAP (500 mg/kg) for 24 h. Groups 3 and 4 fish were exposed to APAP + celery leaf powder (CE) (500 mg/kg) and CE for 24 h, respectively. The severity of liver damage, hepatic lipid, glycogen, ions status and histological alterations was examined. The characterization of CE extract was also performed. APAP-exposed fish showed elevated levels of both circulating and tissue hepatotoxic markers (AST, ALT and ALP), reduced hepatic glycogen and lipid contents (TG and cholesterol), increased tissue lipid peroxidation markers (TBARS, LHP and PCO), altered tissue levels of enzymatic (SOD, CAT, GPx and GST) and non-enzymatic (GSH) antioxidants and cellular thiol levels (T-SH, P-SH and NP-SH), and reduced hepatic ions (Na(+), K(+) and Ca(2+)) and abnormal liver histology. The abnormalities associated with APAP exposure were reversed on treatment with CE. The TLC separation and HPLC quantification of petroleum ether/acetone extract of CE showed the peaks for highly efficient flavonoids such as rutein, quercetin and luteolin. The observed hepatoprotective effect of CE might be due to its rich flavonoids.

  1. Hepatoprotective and Antioxidant Activity of Dunaliella salina in Paracetamol-induced Acute Toxicity in Rats.

    PubMed

    Madkour, Fedekar F; Abdel-Daim, M M

    2013-11-01

    Paracetamol has a reasonable safety profile when taken in therapeutic doses. However, it could induce hepatotoxicity and even more severe fatal acute hepatic damage when taken in an overdose. The green alga, Dunaliella salina was investigated for hepatoprotective and antioxidant activity against paracetamol-induced liver damage in rats. Male albino Wistar rats overdosed with paracetamol showed liver damage and oxidative stress as indicated by significantly (P<0.05) increased serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total and direct bilirubin, malondialdehyde, cholesterol and nitric oxide. At the same time, there were decreased activities of serum superoxide dismutase and total antioxidant capacity compared with the control group. Treatment with D. salina methanol extract at doses of 500 and 1000 mg/kg body weight or silymarin could significantly (P<0.05) decrease the liver damage marker enzymes, total and direct bilirubin, malondialdehyde, cholesterol and nitric oxide levels and increase the activities of superoxide dismutase and total antioxidant capacity in serum when compared with paracetamol intoxicated group. Liver histopathology also showed that D. salina reduced the centrilobular necrosis, congestion and inflammatory cell infiltration evoked by paracetamol overdose. These results suggest that D. salina exhibits a potent hepatoprotective effect on paracetamol-induced liver damage in rats, which may be due to both the increase of antioxidant enzymes activity and inhibition of lipid peroxidation.

  2. Antioxidant activity and hepatoprotective potential of Hammada scoparia against ethanol-induced liver injury in rats.

    PubMed

    Bourogaa, Ezzeddine; Nciri, Riadh; Mezghani-Jarraya, Raoudha; Racaud-Sultan, Claire; Damak, Mohamed; El Feki, Abdelfattah

    2013-06-01

    The present work was aimed at studying the antioxidative activity and hepatoprotective effects of methanolic extract (ME) of Hammada scoparia leaves against ethanol-induced liver injury in male rats. The animals were treated daily with 35 % ethanol solution (4 g kg(-1) day(-1)) during 4 weeks. This treatment led to an increase in the lipid peroxidation, a decrease in antioxidative enzymes (catalase, superoxide dismutase, and glutathione peroxidase) in liver, and a considerable increase in the serum levels of aspartate and alanine aminotransferase and alkaline phospahatase. However, treatment with ME protects efficiently the hepatic function of alcoholic rats by the considerable decrease in aminotransferase contents in serum of ethanol-treated rats. The glycogen synthase kinase-3 β was inhibited after ME administration, which leads to an enhancement of glutathione peroxidase activity in the liver and a decrease in lipid peroxidation rate by 76 %. These biochemical changes were consistent with histopathological observations, suggesting marked hepatoprotective effect of ME. These results strongly suggest that treatment with methanolic extract normalizes various biochemical parameters and protects the liver against ethanol induced oxidative damage in rats. PMID:22893526

  3. Antiproliferative and hepatoprotective activity of metabolites from Corynebacterium xerosis against Ehrlich Ascites Carcinoma cells

    PubMed Central

    Islam, Farhadul; Ghosh, Soby; Khanam, Jahan Ara

    2014-01-01

    Objective To find out the effective anticancer drugs from bacterial products, petroleum ether extract of Corynebacterium xerosis. Methods Antiproliferative activity of the metabolite has been measured by monitoring the parameters like tumor weight measurement, tumor cell growth inhibition in mice and survival time of tumor bearing mice, etc. Hepatoprotective effect of the metabolites was determined by observing biochemical, hematological parameters. Results It has been found that the petroleum ether extract bacterial metabolite significantly decrease cell growth (78.58%; P<0.01), tumor weight (36.04 %; P<0.01) and increase the life span of tumor bearing mice (69.23%; P<0.01) at dose 100 mg/kg (i.p.) in comparison to those of untreated Ehrlich ascites carcinoma (EAC) bearing mice. The metabolite also alters the depleted hematological parameters like red blood cell, white blood cell, hemoglobin (Hb%), etc. towards normal in tumor bearing mice. Metabolite show no adverse effect on liver functions regarding blood glucose, serum alkaline phosphatases, glutamic pyruvic transaminase, glutamic oxaloacetic transaminase activity and serum billirubin, etc. in normal mice. Histopathological observation of these mice organ does not show any toxic effect on cellular structure. But in the case of EAC bearing untreated mice these hematological and biochemical parameters deteriorate extremely with time whereas petroleum ether extract bacterial metabolite receiving EAC bearing mice nullified the toxicity induced by EAC cells. Conclusion Study results reveal that metabolite possesses significant antiproliferative and hepatoprotective effect against EAC cells. PMID:25183099

  4. Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract

    PubMed Central

    Tenkerian, Clara; El-Sibai, Mirvat; Daher, Costantine F.; Mroueh, Mohamad

    2015-01-01

    Tragopogon porrifolius (Asteraceae), commonly referred to as white salsify, is an edible herb used in Lebanese folk medicine to treat cancer and liver dysfunction. In this study, we investigated the antioxidant activity of Tragopogon porrifolius methanolic extract, both in vitro and in vivo, in addition to its hepatoprotective and anticancer activities. Total phenolic and flavonoid contents were measured and found to be 37.0 ± 1.40 mg GAE/g and 16.6 ± 0.42 mg QE/g dry weight, respectively. In vitro antioxidant assays revealed an FRAP value of 659 ± 13.8 µmol Fe2+/g of extract and DPPH IC50 value 15.2 µg/mL. In rats subjected to CCl4-induced hepatotoxicity, significant increase in CAT, SOD, and GST levels was detected. The highest dose of the extract (250 mg/kg) recorded a fold increase of 1.68 for SOD, 2.49 for GST, and 3.2 for CAT. The extract also showed substantial decrease in AST (57%), ALT (56%), and LDH (65%) levels. Additionally, the extract caused a dose-dependent decrease in cell viability and proliferation. In conclusion, the methanolic extract of T. porrifolius displayed a relatively high antioxidant activity both in vitro and in vivo as well as hepatoprotective potential against liver toxicity in rats and anticancer effect on MDA-MB-231 and Caco-2 cells. PMID:25694787

  5. PASS-Predicted Hepatoprotective Activity of Caesalpinia sappan in Thioacetamide-Induced Liver Fibrosis in Rats

    PubMed Central

    Kadir, Farkaad A.; Kassim, Normadiah M.; Abdulla, Mahmood Ameen; Ahmadipour, Fatemeh; Yehye, Wageeh A.

    2014-01-01

    The antifibrotic effects of traditional medicinal herb Caesalpinia sappan (CS) extract on liver fibrosis induced by thioacetamide (TAA) and the expression of transforming growth factor β1 (TGF-β1), α-smooth muscle actin (αSMA), and proliferating cell nuclear antigen (PCNA) in rats were studied. A computer-aided prediction of antioxidant and hepatoprotective activities was primarily performed with the Prediction Activity Spectra of the Substance (PASS) Program. Liver fibrosis was induced in male Sprague Dawley rats by TAA administration (0.03% w/v) in drinking water for a period of 12 weeks. Rats were divided into seven groups: control, TAA, Silymarin (SY), and CS 300 mg/kg body weight and 100 mg/kg groups. The effect of CS on liver fibrogenesis was determined by Masson's trichrome staining, immunohistochemical analysis, and western blotting. In vivo determination of hepatic antioxidant activities, cytochrome P450 2E1 (CYP2E1), and matrix metalloproteinases (MPPS) was employed. CS treatment had significantly increased hepatic antioxidant enzymes activity in the TAA-treated rats. Liver fibrosis was greatly alleviated in rats when treated with CS extract. CS treatment was noted to normalize the expression of TGF-β1, αSMA, PCNA, MMPs, and TIMP1 proteins. PASS-predicted plant activity could efficiently guide in selecting a promising pharmaceutical lead with high accuracy and required antioxidant and hepatoprotective properties. PMID:24701154

  6. Hepatoprotective effects of parsley, basil, and chicory aqueous extracts against dexamethasone-induced in experimental rats

    PubMed Central

    Soliman, Hanan A.; El-Desouky, Mohamed A.; Hozayen, Walaa G.; Ahmed, Rasha R.; Khaliefa, Amal K.

    2016-01-01

    Aim: The objective of this study is to investigate the hypoglycemic, hypolipidemic, and hepatoprotective effects of the aqueous extract of parsley, basil, and chicory whole plant in normal and dexamethasone (Dex) rats. Materials and Methods: 50 female albino rats were used in this study and divided into 5 groups (for each 10). Group (1) fed basal diet and maintained as negative control group. Group (2) received Dex in a dose of (0.1 mg/kg b. wt.). Groups 3, 4, and 5 were treated with Dex along with three different plant extracts of parsley, basil, and chicory (2 g/kg b. wt.), (400 mg/kg b. wt.), and (100 mg/kg b. wt.), respectively. Results: All these groups were treated given three times per week for 8 consecutive weeks. Dex-induced alterations in the levels of serum glucose, triglyceride, cholesterol, low-density lipoprotein-cholesterol levels and cardiovascular indices and serum alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase activities, liver thiobarbituric acid (TBARS) levels increased, while high-density lipoprotein-cholesterol, total protein, albumin, and liver glutathione (GSH) levels decreased. On the other hand, plant extracts succeeded to modulate these observed abnormalities resulting from Dex as indicated by the reduction of glucose, cholesterol, TBARS, and the pronounced improvement of the investigated biochemical and antioxidant parameters. Conclusions: It was concluded that probably, due to its antioxidant property, parsley, basil, and chicory extracts have hepatoprotective effects in Dex-induced in rats. PMID:27069727

  7. Integrated control of emission reductions, energy-saving, and cost-benefit using a multi-objective optimization technique in the pulp and paper industry.

    PubMed

    Wen, Zongguo; Xu, Chang; Zhang, Xueying

    2015-03-17

    Reduction of water pollutant emissions and energy consumption is regarded as a key environmental objective for the pulp and paper industry. The paper develops a bottom-up model called the Industrial Water Pollutant Control and Technology Policy (IWPCTP) based on an industrial technology simulation system and multiconstraint technological optimization. Five policy scenarios covering the business as usual (BAU) scenario, the structural adjustment (SA) scenario, the cleaner technology promotion (CT) scenario, the end-treatment of pollutants (EOP) scenario, and the coupling measures (CM) scenario have been set to describe future policy measures related to the development of the pulp and paper industry from 2010-2020. The outcome of this study indicates that the energy saving amount under the CT scenario is the largest, while that under the SA scenario is the smallest. Under the CT scenario, savings by 2020 include 70 kt/year of chemical oxygen demand (COD) emission reductions and savings of 7443 kt of standard coal, 539.7 ton/year of ammonia nitrogen (NH4-N) emission reductions, and savings of 7444 kt of standard coal. Taking emission reductions, energy savings, and cost-benefit into consideration, cleaner technologies like highly efficient pulp washing, dry and wet feedstock preparation, and horizontal continuous cooking, medium and high consistency pulping and wood dry feedstock preparation are recommended.

  8. Building America Residential System Research Results: Achieving 30% Whole House Energy Savings Level in the Hot-Dry and Mixed-Dry Climates

    SciTech Connect

    Building Industry Research Alliance; Building Science Consortium; Consortium for Advanced Residential Buildings; Davis Energy Group; Florida Solar Energy Center; IBACOS; National Association of Home Builders Research Center; National Renewable Energy Laboratory

    2006-01-01

    The Building America program conducts the system research required to reduce risks associated with the design and construction of homes that use an average of 30% to 90% less total energy for all residential energy uses than the Building America Research Benchmark, including research on homes that will use zero net energy on annual basis. To measure the program's progress, annual research milestones have been established for five major climate regions in the United States. The system research activities required to reach each milestone take from 3 to 5 years to complete and include research in individual test houses, studies in pre-production prototypes, and research studies with lead builders that provide early examples that the specified energy savings level can be successfully achieved on a production basis. This report summarizes research results for the 30% energy savings level and demonstrates that lead builders can successfully provide 30% homes in the Hot-Dry/Mixed-Dry Climate Region on a cost neutral basis.

  9. Looking past the first year: Do the savings last?. A study of the persistence of energy savings in low-income Wisconsin residences, final report

    SciTech Connect

    Narum, D.; Pigg, S.; Schlegel, J.

    1992-09-01

    Wisconsin Energy Conservation Corporation (WECC) conducted a Study of the Persistence of Energy Savings in Low-Income Wisconsin Residences for the Department of Energy`s (DOE) Existing Buildings Efficiency Program. The study assessed the persistence of energy savings resulting from participation in the Wisconsin Utility Weatherization Assistance Program (UWAP). The study assessed the impact of weatherization and heating system measures up to eight years after the installation of energy conservation measures (ECMS) in low-income, gas-heated residences, the majority of which are 1- and 2-unit buildings. Primary data for the study came from two utilities, Wisconsin Gas Company and Madison Gas & Electric Company. Both utilities provided WECC with their weatherization program databases, which contained participant information back to 1982. WECC also obtained fuel consumption information for the program participants from each utility. The consumption histories spanned a 6-year period from March 1985 through May 1991 for Wisconsin Gas Company participants, and a 5-year period from October 1986 through August 1991 for Madison Gas & Electric Company participants. After attrition, the study included 5,129 customers from the Wisconsin Gas Company program and 1,553 customers from the Madison Gas & Electric Company program.

  10. Research on energy-saving optimal control of trains in a following operation under a fixed four-aspect autoblock system based on multi-dimension parallel GA

    NASA Astrophysics Data System (ADS)

    Lu, Qiheng; Feng, Xiaoyun

    2013-03-01

    After analyzing the working principle of the four-aspect fixed autoblock system, an energy-saving control model was created based on the dynamics equations of the trains in order to study the energy-saving optimal control strategy of trains in a following operation. Besides the safety and punctuality, the main aims of the model were the energy consumption and the time error. Based on this model, the static and dynamic speed restraints under a four-aspect fixed autoblock system were put forward. The multi-dimension parallel genetic algorithm (GA) and the external punishment function were adopted to solve this problem. By using the real number coding and the strategy of ramps divided into three parts, the convergence of GA was speeded up and the length of chromosomes was shortened. A vector of Gaussian random disturbance with zero mean was superposed to the mutation operator. The simulation result showed that the method could reduce the energy consumption effectively based on safety and punctuality.

  11. [Effects of sunken depth of energy-saving solar greenhouse on the diurnal variation and spatial distribution of environmental factors in the greenhouse].

    PubMed

    Li, Qing-ming; Zi, Xi-zhen; Yu, Xian-chang

    2011-08-01

    Taking the energy-saving solar greenhouses with the same infrastructure but different sunken depths (0, 0.5, 1.0, and 1.5 m) in Tai' an of Shandong Province as test objects, this paper analyzed the intercepted amount of direct solar radiation energy, and studied the diurnal variation and spatial distribution patterns of environmental factors in the greenhouses on winter solstice (December 20-24, 2009) and summer solstice (June 19-23, 2010). With the increase of sunken depth, the shadow areas in the greenhouses caused by sunken profiles increased gradually, the direct solar radiation energy into the interior of the greenhouses shifted from south to north, and the ratio of ground radiation to back wall radiation decreased gradually. Within the range of 0-1.0 m sunken depth, the air temperature and soil temperature in the greenhouses increased significantly with increasing sunken depth; but when the sunken depth was 1.5 m, the warming effect declined significantly, and the deviation of the lowest soil temperature increased. The deeper the sunken depth, the lower the light intensity and the higher the relative humidity in the greenhouses were. In considering of both lighting and heat preservation, the appropriate sunken depth of energy-saving sunlight greenhouses with a span of 10 m in Tai' an region should be less than 1.0 m.

  12. Investigating the performance and energy saving potential of Chinese commercial building benchmark models for the hot humid and severe cold climate regions

    NASA Astrophysics Data System (ADS)

    Herrmann, Lesley Anne

    2011-12-01

    The demand for energy in China is growing at an alarming rate. Buildings have become a significant component of the energy-demand mix accounting for nearly one-quarter of the country's total primary energy consumption. This study compares the building code standards for office and hotel buildings in the hot humid and severe cold climate regions of China and the United States. Benchmark office and hotel building models have been developed for Guangzhou and Harbin, China that meets China's minimum national and regional building energy codes with the integration of common design and construction practices for each region. These models are compared to the ASHRAE standard based US reference building models for Houston, Texas and Duluth, Minnesota which have similar climate conditions. The research further uses a building energy optimization tool to optimize the Chinese benchmarks using existing US products to identify the primary areas for potential energy savings. In the case of the Harbin models, an economic analysis has also been performed to determine the economic feasibility of alternative building designs. The most significant energy-saving options are then presented as recommendations for potential improvements to current China building energy codes.

  13. Investigation of antioxidant and hepatoprotective activity of standardized Curcuma xanthorrhiza rhizome in carbon tetrachloride-induced hepatic damaged rats.

    PubMed

    Devaraj, Sutha; Ismail, Sabariah; Ramanathan, Surash; Yam, Mun Fei

    2014-01-01

    Curcuma xanthorrhiza (CX) has been used for centuries in traditional system of medicine to treat several diseases such as hepatitis, liver complaints, and diabetes. It has been consumed as food supplement and "jamu" as a remedy for hepatitis. Hence, CX was further explored for its potential as a functional food for liver related diseases. As such, initiative was taken to evaluate the antioxidant and hepatoprotective potential of CX rhizome. Antioxidant activity of the standardized CX fractions was determined using in vitro assays. Hepatoprotective assay was conducted against carbon tetrachloride- (CCl4-) induced hepatic damage in rats at doses of 125, 250, and 500 mg/kg of hexane fraction. Highest antioxidant activity was found in hexane fraction. In the case of hepatoprotective activity, CX hexane fraction showed significant improvement in terms of a biochemical liver function, antioxidative liver enzymes, and lipid peroxidation activity. Good recovery was observed in the treated hepatic tissues histologically. Hence, the results concluded that CX hexane fraction possessed prominent hepatoprotective activities which might be due to its in vitro antioxidant activity. These findings also support the use of CX as a functional food for hepatitis remedy in traditional medicinal system. PMID:25133223

  14. Audit Report on "The Department of Energy's Opportunity for Energy Savings Through the Use of Setbacks in its Facilities"

    SciTech Connect

    2009-07-01

    the operation of setback capabilities in building lease agreements. This was especially troubling given the expanded use of leased space to house Departmental operations. Despite discussions with several Federal and contractor officials, we could not obtain what we considered to be a satisfactory explanation as to why the Department failed to take advantage of this conservation practice, one that is generally low cost and has limited, if any, adverse impact on operations or building occupants. Consistent with the lack of emphasis in this area, we noted that the Department had not required the four contractors included in our review to develop training requirements or energy policies and procedures governing the use of setback capabilities. Energy consumption reduction goals related to setbacks had also not been established to help incentivize contractor performance in this important area. With nearly $300 million in annual utility costs, the Department could realize significant savings by using setbacks in its buildings. We estimate that the Department could save over $11.5 million in annual utility costs. We developed the estimate based on the observation that approximately 64 percent of the facilities included in our review had not used setbacks. We then conservatively applied a 15 percent energy consumption savings estimate observed by Sandia National Laboratory and savings estimates contained in a study conducted by Pacific Northwest National Laboratory to the 40 percent of utility costs generally recognized as resulting from HVAC operation. Such savings could be used to fund high priority programs and install additional energy saving features. The consumption savings would be, at today's average residential electricity cost, sufficient to power over 9,800 homes each year. We recognize that while setbacks can be used in many situations, they are not appropriate for facilities that are continuously operated or those that house delicate equipment that depend on

  15. Hepatoprotective potential of kumaryasava and its concentrate against CCl4-induced hepatic toxicity in Wistar rats

    PubMed Central

    Khan, Mohammad Ahmed; Gupta, Arun; Sastry, J. L. N.; Ahmad, Sayeed

    2015-01-01

    Objective: Kumaryasava (KS) is a marketed Ayurvedic formulation containing Aloe vera as the main ingredient. It has been used widely for the treatment of liver disorders; however, there is a lack of modern scientific data on hepatoprotection. The recommended dose of KS is high and up to 60 mL/day. The present study describes the preparation of new KS concentrate and evaluation of comparative hepatoprotective activity of KS and prepared KS concentrate at one-third of KS dose against CCl4-induced hepatic toxicity. Materials and Methods: Animals were divided into different groups (n = 6). The first group received normal saline (control) 1.0 mL/Kg/day p.o. for 10 days. The second group (toxicant) was given normal saline 1.0 mL/Kg/day p.o. for 10 days with CCl4 in olive oil (1:1 v/v) at 1.0 mL/Kg/day p.o. Third, fourth, and fifth groups received KS, KS concentrate and a marketed formulation as standard) at doses of 5.0 mL/Kg/day p.o., 1.6 mL/Kg/day p.o., and 100 mL/Kg/day p.o. (tablet suspended in water using 0.1% carboxymethyl cellulose) respectively for 10 days along with CCl4 as given to the toxicant group. On the 11th day, blood was withdrawn from retro-orbital plexus and serum was separated for biochemical estimation of serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP), and albumin levels. Later, animals were sacrificed under high dose of anesthesia to remove liver tissue, which were removed and washed with ice cold saline for the estimation of lipid peroxidation. Liver tissue from each group was also fixed in 10% formalin for histopathological analysis. Results: Results demonstrated that both KS and KS concentrate showed the protection against CCl4-induced hepatic toxicity. This was evident from the reduction in serum SGOT, SGPT, ALP levels, and elevation in serum albumin levels observed post treatment of CCl4 treated rats with KS and KS concentrate, which were supported by histopathological data

  16. Energy savings for heat-island reduction strategies in Chicago and Houston (including updates for Baton Rouge, Sacramento, and Salt Lake City)

    SciTech Connect

    Konopacki, S.; Akbari, H.

    2002-02-28

    In 1997, the U.S. Environmental Protection Agency (EPA) established the ''Heat Island Reduction Initiative'' to quantify the potential benefits of Heat-Island Reduction (HIR) strategies (i.e., shade trees, reflective roofs, reflective pavements and urban vegetation) to reduce cooling-energy use in buildings, lower the ambient air temperature and improve urban air quality in cities, and reduce CO2 emissions from power plants. Under this initiative, the Urban Heat Island Pilot Project (UHIPP) was created with the objective of investigating the potential of HIR strategies in residential and commercial buildings in three initial UHIPP cities: Baton Rouge, LA; Sacramento, CA; and Salt Lake City, UT. Later two other cities, Chicago, IL and Houston, TX were added to the UHIPP. In an earlier report we summarized our efforts to calculate the annual energy savings, peak power avoidance, and annual CO2 reduction obtainable from the introduction of HIR strategies in the initial three cities. This report summarizes the results of our study for Chicago and Houston. In this analysis, we focused on three building types that offer the highest potential savings: single-family residence, office and retail store. Each building type was characterized in detail by vintage and system type (i.e., old and new building constructions, and gas and electric heat). We used the prototypical building characteristics developed earlier for each building type and simulated the impact of HIR strategies on building cooling- and heating-energy use and peak power demand using the DOE-2.1E model. Our simulations included the impact of (1) strategically-placed shade trees near buildings [direct effect], (2) use of high-albedo roofing material on the building [direct effect], (3) urban reforestation with high-albedo pavements and building surfaces [indirect effect] and (4) combined strategies 1, 2, and 3 [direct and indirect effects]. We then estimated the total roof area of air-conditioned buildings in

  17. Evaluation of Hepatoprotective Activity of Adansonia digitata Extract on Acetaminophen-Induced Hepatotoxicity in Rats.

    PubMed

    Hanafy, Abeer; Aldawsari, Hibah M; Badr, Jihan M; Ibrahim, Amany K; Abdel-Hady, Seham El-Sayed

    2016-01-01

    The methanol extract of the fruit pulp of Adansonia digitata L. (Malvaceae) was examined for its hepatoprotective activity against liver damage induced by acetaminophen in rats. The principle depends on the fact that administration of acetaminophen will be associated with development of oxidative stress. In addition, hepatospecific serum markers will be disturbed. Treatment of the rats with the methanol extract of the fruit pulp of Adansonia digitata L. prior to administration of acetaminophen significantly reduced the disturbance in liver function. Liver functions were measured by assessment of total protein, total bilirubin, ALP, ALT, and AST. Oxidative stress parameter and antioxidant markers were also evaluated. Moreover, histopathological evaluation was performed in order to assess liver case regarding inflammatory infiltration or necrosis. Animals were observed for any symptoms of toxicity after administration of extract of the fruit pulp of Adansonia digitata L. to ensure safety of the fruit extract. PMID:27118980

  18. From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective.

    PubMed

    Rudraiah, Swetha; Manautou, José E

    2016-01-01

    A variety of rodent models of hepatoprotection have been developed in which tolerance to acetaminophen-induced hepatotoxicity occurs. Autoprotection/heteroprotection is a phenomenon where prior exposure to a mildly toxic dose of toxicant confers protection against a subsequently administered higher dose of the same toxicant (as in the case of autoprotection) or to a different toxicant (referred to as heteroprotection). Multiple mechanisms regulate this adaptive response, including hepatocellular proliferation, proteostasis, enhanced expression of cytoprotective genes, and altered tissue immune response. In this review, we will discuss recent findings that highlight the complexity of these adaptive mechanisms and we also outline the usefulness of these findings to devise therapeutic and/or diagnostic tools for acetaminophen-induced liver damage in patients. PMID:27499850

  19. Isolation, preliminary characterization and hepatoprotective activity of polysaccharides from Tamarindus indica L.

    PubMed

    Samal, Predeep Kumar; Dangi, Jawahar Singh

    2014-02-15

    Polysaccharide was isolated from Tamarindus indica L. (TIP) and was characterized in terms of moisture and ash content, pH, water holding capacity, particle size, tapped density, bulk density, carr's index, Hausners ratio, angle of repose, content of glucose, uronic acid and sulfate. Morphological, spectral (UV-vis, FTIR) and DSC thermal analysis reveals polysaccharide nature of the isolated starch. DPPH radical scavenging activity of TIP shows RSA comparable to that of silymarin. Hepatoprotective potential of TIP in terms of biochemical parameters, SGOT, SGPT, ALP and BRN were significantly increased (P<0.05) and reduction of serum Total protein in the group of rats given thioacetamide (100mg/kg s.c.). Histopathology reveals that TIP under antagonize the effect of thioacetamide by acting, either as membrane stabilizer, thereby preventing the distortion of the cellular ionic environment associated with thioacetamide intoxication, or by preventing interaction of thioacetamide with the transcriptional machinery of the cells.

  20. Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats.

    PubMed

    Pari, L; Kumar, N Ashok

    2002-01-01

    Moringa oleifera Lam (Moringaceae), commonly known as "Drumstick," is used in Indian folk medicine for the treatment of various illness. We have evaluated the hepatoprotective effect of an ethanolic extract of M. oleifera leaves on liver damage induced by antitubercular drugs such as isoniazid (INH), rifampicin (RMP), and pyrazinamide (PZA) in rats. Oral administration of the extract showed a significant protective action made evident by its effect on the levels of glutamic oxaloacetic transaminase (aspartate aminotransferase), glutamic pyruvic transaminase (alanine aminotransferase), alkaline phosphatase, and bilirubin in the serum; lipids, and lipid peroxidation levels in liver. This observation was supplemented by histopathological examination of liver sections. The results of this study showed that treatment with M. oleifera extracts or silymarin (as a reference) appears to enhance the recovery from hepatic damage induced by antitubercular drugs. PMID:12495589