Venus within ESA probe reach

NASA Astrophysics Data System (ADS)

2006-03-01

Venus Express mission controllers at the ESA Space Operations Centre (ESOC) in Darmstadt, Germany are making intensive preparations for orbit insertion. This comprises a series of telecommands, engine burns and manoeuvres designed to slow the spacecraft down from a velocity of 29000 km per hour relative to Venus, just before the first burn, to an entry velocity some 15% slower, allowing the probe to be captured into orbit around the planet. The spacecraft will have to ignite its main engine for 50 minutes in order to achieve deceleration and place itself into a highly elliptical orbit around the planet. Most of its 570 kg of onboard propellant will be used for this manoeuvre. The spacecraft’s solar arrays will be positioned so as to reduce the possibility of excessive mechanical load during engine ignition. Over the subsequent days, a series of additional burns will be done to lower the orbit apocentre and to control the pericentre. The aim is to end up in a 24-hour orbit around Venus early in May. The Venus orbit injection operations can be followed live at ESA establishments, with ESOC acting as focal point of interest (see attached programme). In all establishments, ESA specialists will be on hand for interviews. ESA TV will cover this event live from ESOC in Darmstadt. The live transmission will be carried free-to-air. For broadcasters, complete details of the various satellite feeds are listed at http://television.esa.int. The event will be covered on the web at venus.esa.int. The website will feature regular updates, including video coverage of the press conference and podcast from the control room at ESA’s Operations Centre. Media representatives wishing to follow the event at one of the ESA establishments listed below are requested to fill in the attached registration form and fax it back to the place of their choice. For further information, please contact: ESA Media Relations Division Tel : +33(0)1.53.69.7155 Fax: +33(0)1.53.69.7690 Venus Express Orbit Insertion - Tuesday 11 April 2006 ESA/ESOC, Robert Bosch Strasse, 5 - Darmstadt (Germany) PROGRAMME 07:30 - Doors open 08:45 - Start of local event, welcome addresses 09:10 - ESA TV live from Mission Control Room (MCR) starts 09:17 - Engine burn sequence starts 09:45 - Occultation of spacecraft by Venus starts 09:55 - Occultation ends 10:07 - Main engine burn ends 10:20 - Address by Jean-Jacques Dordain, ESA’s Director General, and other officials Break and buffet Interview opportunities 11:30-12:15 - Press Conference Jean-Jacques Dordain, Director General, ESA Prof. David Southwood, Director of Science, ESA Gaele Winters, Director of Operations and Infrastructure, ESA Manfred Warhaut, Flight Operations Director, ESA Håkan Svedhem, Venus Express Project Scientist, ESA Don McCoy, Venus Express Project Manager, ESA 13:15 - End of event at ESOC ACCREDITATION REQUEST FORM Venus Express Orbit Insertion - ESA/ESOC Darmstadt - 11 April 2006 First name:___________________ Surname:_____________________ Media:______________________________________________________ Address: ___________________________________________________ ____________________________________________________________ Tel:_______________________ Fax: ___________________________ Mobile :___________________ E-mail: ________________________ I will be attending the Venus Express Orbit Insertion event at the following site: [ ] Germany Location: ESA/ESOC Address: Robert Bosch Strasse 5, Darmstadt, Germany Opening hours: 07:30 - 13:00 Contact: Jocelyne Landeau-Constantin, Tel: +49.6151.902.696 - Fax: +49.6151.902.961 [ ] France Location: ESA HQ Address: 8/10, rue Mario Nikis - Paris 15, France Opening hours: 08:00 - 13:00 Contact: Anne-Marie Remondin - Tel: +33(0)1.53.69.7155 - fax: +33(0)1.53.69.7690 [ ] The Netherlands Location: Newton Room, ESA/ESTEC Address: Keplerlaan 1, Noordwijk, The Netherlands Opening hours: 08:30 - 12:30 Contact: Michel van Baal, tel. + 31 71 565 3006, fax + 31 71 565 5728 [ ] Italy Location: ESA/ESRIN Address: Via Galileo Galilei, Frascati (Rome), Italy Opening hours: 07:00 - 14:00 Contact: Franca Morgia - Tel: +39.06.9418.0951 - Fax: +39.06.9418.0952 [ ] Spain Location: ESA/ESAC Address: Urbanización Villafranca del Castillo, Villanueva de la Cañada, Madrid, Spain Opening hours: 8:30 - 13:30 Contact: Monica Oerke, Tel + 34 91 813 13 27/59 - Fax: + 34 91 813 12 19

Flight Investigation of the Knock-Limited Performance of a Triptane Blend, a Toluene Blend, and 28-R Fuel in an R-1830-75 Engine

NASA Technical Reports Server (NTRS)

Blackman, Calvin C.

1946-01-01

Knock-limited performance data were obtained for three fuels on an R-1830-75 engine in a B-24D airplane at engine speeds of 1800, 2250, and 2600 rpm, a spark advance of 25 degrees B.T.C., and carburetor-air temperatures of 85 F for 1800 and 2250 rpm and 100 F for 2600 rpm. The test fuels were a blend of 80 percent 28-R plus 20 percent triptane (leaded to 4.5 ml TEL/gal), a blend of 80 percent 28-R plus 15 percent toluene (leaded to 4.5 ml TEL / gal), and 28-R fuel. The knock-limited manifold pressure of the toluene blend depreciated more in the lean region than the triptane blend or 28-R fuel. The knock-limited brake horsepower for the triptane blend varied from 16 to 25 percent higher than 28-R in the lean region and 18 to 30 percent higher in the rich region. The knock-limited brake horsepower of the toluene blend was approximately 15 percent higher than that of 28-R in the rich region and varied from 2 to 10 percent higher in the lean region. Knock limits of the triptane blend and 28-R fuel tested in the R-1830-75 engine agreed with limits for the same fuels determined with the R-1830-94 engine for engine speeds of 1800 and 2250 rpm.

Performance Art at the Campusphere: Pedagogical Experiments On-Site

ERIC Educational Resources Information Center

Ben-Shaul, Daphna

2018-01-01

Following a unique practice and research laboratory entitled "Performance: Site/Self" that took place in 2013-2015, this article discusses the implementation of performance art at an academic site--the Tel Aviv University campus. This pedagogical and artistic initiative, characterised by the transgressive pedagogy of performance art…

The P-38 Lightning Aircraft: Lessons Learned for Future Weapon Systems Development

DTIC Science & Technology

2010-04-01

PMBOK TEL \\ u.s. WER List of ~cronyms iv Brake Horse Power Design-Build Team District of Columbia Department of Defense Department of...record. Despite unresolved issues like the flap and brake system problems and limited test hours, on 11 February 1939, Lieutenant Kelsey flew the XP-38...engine, giving the P-3 8 engines a 1425 brake horse power (BHP)22 rating. However, limitations of the integral wing leading edge intercoolers23 could

Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.

PubMed

Anderson, Carol M; Korkin, Dmitry; Smith, Dana L; Makovets, Svetlana; Seidel, Jeffrey J; Sali, Andrej; Blackburn, Elizabeth H

2008-04-01

The kinases ATM and ATR (Tel1 and Mec1 in the yeast Saccharomyces cerevisiae) control the response to DNA damage. We report that S. cerevisiae Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling. We show that Tel1 and Tel2 interact, and that even when Tel1 protein levels are high, this interaction is specifically required for Tel1 localization to a DNA break and its activation of downstream targets. Computational analysis revealed structural homology between Tel2 and Ddc2 (ATRIP in vertebrates), a partner of Mec1, suggesting a common structural principle used by partners of phoshoinositide 3-kinase-like kinases.

CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe.

PubMed

Inoue, Haruna; Sugimoto, Shizuka; Takeshita, Yumiko; Takeuchi, Miho; Hatanaka, Mitsuko; Nagao, Koji; Hayashi, Takeshi; Kokubu, Aya; Yanagida, Mitsuhiro; Kanoh, Junko

2017-01-01

An evolutionarily conserved protein Tel2 regulates a variety of stress signals. In mammals, TEL2 associates with TTI1 and TTI2 to form the Triple T (TTT: TEL2-TTI1-TTI2) complex as well as with all the phosphatidylinositol 3-kinase-like kinases (PIKKs) and the R2TP (Ruvbl1-Ruvbl2-Tah1-Pih1 in budding yeast)/prefoldin-like complex that associates with HSP90. The phosphorylation of TEL2 by casein kinase 2 (CK2) enables direct binding of PIHD1 (mammalian Pih1) to TEL2 and is important for the stability and the functions of PIKKs. However, the regulatory mechanisms of Tel2 in fission yeast Schizosaccharomyces pombe remain largely unknown. Here, we report that S. pombe Tel2 is phosphorylated by CK2 at Ser490 and Thr493. Tel2 forms the TTT complex with Tti1 and Tti2 and also associates with PIKKs, Rvb2, and Hsp90 in vivo; however, the phosphorylation of Tel2 affects neither the stability of the Tel2-associated proteins nor their association with Tel2. Thus, Tel2 stably associates with its binding partners irrespective of its phosphorylation. Furthermore, the Tel2 phosphorylation by CK2 is not required for the various stress responses to which PIKKs are pivotal. Our results suggest that the Tel2-containing protein complexes are conserved among eukaryotes, but the molecular regulation of their formation has been altered during evolution. © 2016 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.

First Spectroscopic Solutions of Two Southern Eclipsing Binaries: HO Tel and QY Tel

NASA Astrophysics Data System (ADS)

Sürgit, D.; Erdem, A.; Engelbrecht, C. A.; van Heerden, P.; Manick, R.

2015-07-01

We present preliminary results from the analysis of spectroscopic observations of two southern eclipsing binary stars, HO Tel and QY Tel. The grating spectra of these two systems were obtained at the Sutherland Station of the South African Astronomical Observatory in 2013. Radial velocities of the components were determined by the Fourier disentangling technique. Keplerian radial velocity models of HO Tel and QY Tel give their mass ratio as 0.921±0.005 and 1.089±0.007, respectively.

Structure and vascular tissue expression of duplicated TERMINAL EAR1-like paralogues in poplar.

PubMed

Charon, Céline; Vivancos, Julien; Mazubert, Christelle; Paquet, Nicolas; Pilate, Gilles; Dron, Michel

2010-02-01

TERMINAL EAR1-like (TEL) genes encode putative RNA-binding proteins only found in land plants. Previous studies suggested that they may regulate tissue and organ initiation in Poaceae. Two TEL genes were identified in both Populus trichocarpa and the hybrid aspen Populus tremula x P. alba, named, respectively, PoptrTEL1-2 and PtaTEL1-2. The analysis of the organisation around the PoptrTEL genes in the P. trichocarpa genome and the estimation of the synonymous substitution rate for PtaTEL1-2 genes indicate that the paralogous link between these two Populus TEL genes probably results from the Salicoid large-scale gene-duplication event. Phylogenetic analyses confirmed their orthology link with the other TEL genes. The expression pattern of both PtaTEL genes appeared to be restricted to the mother cells of the plant body: leaf founder cells, leaf primordia, axillary buds and root differentiating tissues, as well as to mother cells of vascular tissues. Most interestingly, PtaTEL1-2 transcripts were found in differentiating cells of secondary xylem and phloem, but probably not in the cambium itself. Taken together, these results indicate specific expression of the TEL genes in differentiating cells controlling tissue and organ development in Populus (and other Angiosperm species).

Integrating Trends in Decision-Making Research

DTIC Science & Technology

2016-03-01

Address correspondence to Cleotilde Gonzalez, Department of Social and Decision Sciences, Dynamic Decision Making Lab, Carnegie Mellon University...Cleotilde Gonzalez, Carnegie Mellon University, and Joachim Meyer, Tel-Aviv University Journal of Cognitive Engineering and Decision Making 201X, Volume XX...Number X, Month 2016, pp. 1 –3 DOI: 10.1177/1555343416655256 Copyright © 2016, Human Factors and Ergonomics Society. at CARNEGIE MELLON UNIV LIBRARY

Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9

PubMed Central

Chakrabarti, Subhra Ranjan; Sood, Rashmi; Ganguly, Surajit; Bohlander, Stefan; Shen, Zhiyuan; Nucifora, Giuseppina

1999-01-01

The E-26 transforming specific (ETS)-related gene TEL, also known as ETV6, is involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. The encoded protein contains two functional domains: a helix–loop–helix (HLH) domain (also known as pointed domain) located at the N terminus and a DNA-binding domain located at the C terminus. The HLH domain is involved in protein–protein interaction with itself and other members of the ETS family of transcription factors such as FLI1. TEL is a transcription factor, and we and others have shown that it is a repressor of gene expression. To understand further the role of TEL in the cell, we have used an in vivo interaction system to identify proteins that interact with TEL. We show that a protein, UBC9, interacts specifically with TEL in vitro and in vivo. UBC9 is a member of the family of ubiquitin-conjugating enzymes. These enzymes usually are involved in proteosome-mediated degradation; however, our data suggest that interaction of TEL with UBC9 does not lead to TEL degradation. Our studies show that UBC9 binds to TEL exclusively through the HLH domain of TEL. We also show that TEL expressed as fusion to the DNA-binding domain of Gal4 completely represses a Gal4-responsive promoter, but that the coexpression of UBC9 in the same system restores the activity of the promoter. Targeted point mutation of conserved amino acids in UBC9 essential for enzymatic ubiquitination of proteins does not affect interaction nor transcriptional activity. Based on our data, we conclude that UBC9 physically interacts with TEL through the HLH domain and that the interaction leads to modulation of the transcription activity of TEL. PMID:10377438

Late ovarian relapse of TEL/AML1 positive ALL confirming that TEL deletion is a secondary event in leukemogenesis.

PubMed

Ly-Sunnaram, Beatrice; Henry, Catherine; Gandemer, Virginie; Mee, Franseza Le; Burtin, Florence; Blayau, Martine; Cayuela, Jean-Michel; Oster, Magalie; Clech, Philippe; Rambeau, Marc; Marie, Celine; Pampin, Cecilia; Edan, Christine; Gall, Edouard Le; Goasguen, Jean E

2005-09-01

We describe here a late extramedullary ovarian relapse in an 18-year-old female who was diagnosed with hypotetraploid cell acute lymphoblastic leukaemia (cALL) at the age of 6. At both occurrences of the disease cells were analyzed by morphology, immunophenotyping, cytogenetics and molecular methods. TEL/AML1 was detected by RT-PCR and FISH analysis in both events. We demonstrated, using detection of IGH/TCR rearrangements and TEL/AML1 breakpoints sequencing that the cells were clonally related. Moreover, interphasic FISH using TEL and AML1 probes showed the loss of a second TEL at the time of relapse. This observation confirms that TEL/AML1 alone is not sufficient to trigger ALL and that TEL deletion is a secondary event in leukemogenesis. To our knowledge, it is the first complete description of extramedullary ALL relapse combining all methodologies.

Turbine Engine Loads Simulator (TELS) Radiographic Systems Requirements Study

DTIC Science & Technology

1977-06-01

cell and viewed from the rear. Locations of the rotor case pinch points are illustrated in Figures C-4 through C-! 9. Table C-Ill represents the test...radiation is also attentuated by air, therefore we can write: pb2 03 EXP(~a b) ( El4 ) W = [ K---~-T X1 ] Let U = T = 1, P = 0.01 rads, #a = 3 x 10 -5 cm

Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage

PubMed Central

Cain, Jennifer A.; Xiang, Zhifu; O'Neal, Julie; Kreisel, Friederike; Colson, AnnaLynn; Luo, Hui; Hennighausen, Lothar

2007-01-01

Expression of the constitutively activated TEL/PDGFβR fusion protein is associated with the t(5;12)(q33;p13) chromosomal translocation found in a subset of patients with chronic myelomonocytic leukemia. TEL/PDGFβR activates multiple signal transduction pathways in cell-culture systems, and expression of the TEL-PDGFRB fusion gene induces myeloproliferative disease (MPD) in mice. We used gene-targeted mice to characterize the contribution of signal transducer and activator of transcription (Stat) and Src family genes to TEL-PDGFRB–mediated transformation in methylcellulose colony and murine bone marrow transduction/transplantation assays. Fetal liver hematopoietic stem and progenitor cells harboring targeted deletion of both Stat5a and Stat5b (Stat5abnull/null) genes were refractory to transformation by TEL-PDGFRB in methylcellulose colony assays. Notably, these cell populations were maintained in Stat5abnull/null fetal livers and succumbed to transformation by c-Myc. Surprisingly, targeted disruption of either Stat5a or Stat5b alone also impaired TEL-PDGFRB–mediated transformation. Survival of TPiGFP→Stat5a−/− and TPiGFP→Stat5a+/− mice was significantly prolonged, demonstrating significant sensitivity of TEL-PDGFRB–induced MPD to the dosage of Stat5a. TEL-PDGFRB–mediated MPD was incompletely penetrant in TPiGFP→Stat5b−/− mice. In contrast, Src family kinases Lyn, Hck, and Fgr and the Stat family member Stat1 were dispensable for TEL-PDGFRB disease. Together, these data demonstrate that Stat5a and Stat5b are dose-limiting mediators of TEL-PDGFRB–induced myeloproliferation. PMID:17218386

Novel Connections Between DNA Replication, Telomere Homeostasis, and the DNA Damage Response Revealed by a Genome-Wide Screen for TEL1/ATM Interactions in Saccharomyces cerevisiae

PubMed Central

Piening, Brian D.; Huang, Dongqing; Paulovich, Amanda G.

2013-01-01

Tel1 is the budding yeast ortholog of the mammalian tumor suppressor and DNA damage response (DDR) kinase ATM. However, tel1-Δ cells, unlike ATM-deficient cells, do not exhibit sensitivity to DNA-damaging agents, but do display shortened (but stably maintained) telomere lengths. Neither the extent to which Tel1p functions in the DDR nor the mechanism by which Tel1 contributes to telomere metabolism is well understood. To address the first question, we present the results from a comprehensive genome-wide screen for genetic interactions with tel1-Δ that cause sensitivity to methyl methanesulfonate (MMS) and/or ionizing radiation, along with follow-up characterizations of the 13 interactions yielded by this screen. Surprisingly, many of the tel1-Δ interactions that confer DNA damage sensitivity also exacerbate the short telomere phenotype, suggesting a connection between these two phenomena. Restoration of normal telomere length in the tel1-Δ xxx-Δ mutants results in only minor suppression of the DNA damage sensitivity, demonstrating that the sensitivity of these mutants must also involve mechanisms independent of telomere length. In support of a model for increased replication stress in the tel1-Δ xxx-Δ mutants, we show that depletion of dNTP pools through pretreatment with hydroxyurea renders tel1-Δ cells (but not wild type) MMS-sensitive, demonstrating that, under certain conditions, Tel1p does indeed play a critical role in the DDR. PMID:23378069

Genetic and Physical Interactions between Tel2 and the Med15 Mediator Subunit in Saccharomyces cerevisiae

PubMed Central

Grandin, Nathalie; Corset, Laetitia; Charbonneau, Michel

2012-01-01

Background In budding yeast, the highly conserved Tel2 protein is part of several complexes and its main function is now believed to be in the biogenesis of phosphatidyl inositol 3-kinase related kinases. Principal Findings To uncover potentially novel functions of Tel2, we set out to isolate temperature-sensitive (ts) mutant alleles of TEL2 in order to perform genetic screenings. MED15/GAL11, a subunit of Mediator, a general regulator of transcription, was isolated as a suppressor of these mutants. The isolated tel2 mutants exhibited a short telomere phenotype that was partially rescued by MED15/GAL11 overexpression. The tel2-15mutant was markedly deficient in the transcription of EST2, coding for the catalytic subunit of telomerase, potentially explaining the short telomere phenotype of this mutant. In parallel, a two-hybrid screen identified an association between Tel2 and Rvb2, a highly conserved member of the AAA+ family of ATPases further found by in vivo co-immunoprecipitation to be tight and constitutive. Transiently overproduced Tel2 and Med15/Gal11 associated together, suggesting a potential role for Tel2 in transcription. Other Mediator subunits, as well as SUA7/TFIIB, also rescued the tel2-ts mutants. Significance Altogether, the present data suggest the existence of a novel role for Tel2, namely in transcription, possibly in cooperation with Rvb2 and involving the existence of physical interactions with the Med15/Gal11 Mediator subunit. PMID:22291956

78 FR 21497 - Publication of General Licenses Related to the Burma Sanctions Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-10

... General License No. 19. FOR FURTHER INFORMATION CONTACT: Assistant Director for Sanctions Compliance & Evaluation, tel.: 202-622-2490, Assistant Director for Licensing, tel.: 202-622-2480, Assistant Director for Regulatory Affairs, tel.: 202-622-4855, Assistant Director for Policy, tel.: 202- 622-2746, Office of Foreign...

Draft Whole-Genome Sequence of Serratia sp. Strain TEL, Associated with Oscheius sp. TEL-2014 (Nematoda: Rhabditidae) Isolated from a Grassland in South Africa.

PubMed

Lephoto, Tiisetso E; Featherston, Jonathan; Gray, Vincent M

2015-07-09

Here, we report on the draft genome sequence of Serratia sp. strain TEL, associated with Oscheius sp. TEL-2014 (Nematoda: Rhabditidae, KM492926) isolated from a grassland in Suikerbosrand Nature Reserve near Johannesburg in South Africa. Serratia sp. strain TEL has a genome size of 5,000,541 bp with 4,647 genes and a G+C content of 59.1%. Copyright © 2015 Lephoto et al.

Linking Emotional Intelligence to Achieve Technology Enhanced Learning in Higher Education

ERIC Educational Resources Information Center

Kruger, Janette; Blignaut, A. Seugnet

2013-01-01

Higher education institutions (HEIs) increasingly use technology-enhanced learning (TEL) environments (e.g. blended learning and e-learning) to improve student throughput and retention rates. As the demand for TEL courses increases, expectations rise for faculty to meet the challenge of using TEL effectively. The promises that TEL holds have not…

Telephone-based continuing care counseling in substance abuse treatment: economic analysis of a randomized trial

PubMed Central

Daley, Marilyn C.; Neuman, Matthew J.; Blaakman, Aaron P.; McKay, James R.

2016-01-01

Purpose To investigate whether telephone-based continuing care (TEL) is a promising alternative to traditional face-to-face counseling for clients in treatment for substance abuse. Methods Patients with alcohol and/or cocaine dependence who had completed a 4-week intensive outpatient program were randomly assigned through urn randomization into one of three 12-week interventions: standard continuing care (STD), in-person relapse prevention (RP), or telephone-based continuing care (TEL). This study performed cost, cost-effectiveness, and cost-benefit analyses of TEL and RP compared to STD, using results from the randomized clinical trial with two years of follow up (359 participants). In addition, the study examined the potential moderating effect of baseline patient costs on economic outcomes. Results The study found that TEL was less expensive per client from the societal perspective ($569) than STD ($870) or RP ($1,684). TEL also was also significantly more effective, with an abstinence rate of 57.1% compared to 46.7% for STD (p<0.05). Thus TEL dominated STD, with a highly favorable negative incremental cost-effectiveness ratio (−$1,400 per abstinent year). TEL also proved favorable under a benefit-cost perspective. Conclusions TEL proved to be a cost-effective and cost-beneficial contributor to long-term recovery over two years. Because TEL dominated STD care interventions, wider adoption should be considered. PMID:26718395

Telephone-based continuing care counseling in substance abuse treatment: Economic analysis of a randomized trial.

PubMed

Shepard, Donald S; Daley, Marilyn C; Neuman, Matthew J; Blaakman, Aaron P; McKay, James R

2016-02-01

To investigate whether telephone-based continuing care (TEL) is a promising alternative to traditional face-to-face counseling for clients in treatment for substance abuse. Patients with alcohol and/or cocaine dependence who had completed a 4-week intensive outpatient program were randomly assigned through urn randomization into one of three 12-week interventions: standard continuing care (STD), in-person relapse prevention (RP), or telephone-based continuing care (TEL). This study performed cost, cost-effectiveness, and cost-benefit analyses of TEL and RP compared to STD, using results from the randomized clinical trial with two years of follow up (359 participants). In addition, the study examined the potential moderating effect of baseline patient costs on economic outcomes. The study found that TEL was less expensive per client from the societal perspective ($569) than STD ($870) or RP ($1684). TEL also was also significantly more effective, with an abstinence rate of 57.1% compared to 46.7% for STD (p<0.05). Thus TEL dominated STD, with a highly favorable negative incremental cost-effectiveness ratio (-$1400 per abstinent year). TEL also proved favorable under a benefit-cost perspective. TEL proved to be a cost-effective and cost-beneficial contributor to long-term recovery over two years. Because TEL dominated STD care interventions, wider adoption should be considered. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

The role of vasoactive intestinal peptide in neuroprotection: Professor Illana Gozes is interviewed by Emma Quigley.

PubMed

Gozes, Illana

2007-06-01

Professor Illana Gozes was interviewed by Emma Quigley (Senior Editor, Expert Opinion) on 17(th) April 2007. Professor Illana Gozes BSc, PhD holds the titles of Professor of Clinical Biochemistry; The Lily and Avraham Gildor Chair for the Investigation of Growth Factors; Director of Adams Super Center for Brain Studies and Levi-Edersheim-Gitter fMRI Institute; Head of the Dr Diana and Zelman Elton (Elbaum) Laboratory for Molecular Neuroendocrinology, Tel Aviv University and Chief Scientific Officer, Allon Therapeutics, Inc., Vancouver BC, Canada. Professor Gozes has served as a member (or chair) of several faculty, university or national and international committees and she currently serves on the Board of Directors of Allon Therapeutics, the Scientific Review Board of the ISOA, and is the Editor-in-Chief of the Journal of Molecular Neuroscience. Professor Gozes has received a number of scientific awards for her work including the Landau Award for an excellent PhD dissertation, the Juludan Prize and the Teva Founders Prize for exceptional scientific studies that may lead to biotechnology developments as well as the Bergmann Prize and the Neufeld award for outstanding/leading US-Israel BSF grant proposals, and has published extensively in the fields of molecular neuroscience and neuroprotection (> 200 scientific manuscripts). She is co-inventor of > 15 patents and applications, including the composition of matter patent on AL-108 and AL-208, Allon's lead compounds. Professor Gozes received a BSc from Tel Aviv University, a PhD from The Weizmann Institute of Science and was a Weizmann Postdoctoral Fellow at Massachusetts Institute of Technology, Research Associate/Visiting Scientist at the Salk Institute and the Scripps Clinic and Research Foundation, a Senior Scientist/Associate Professor at the Weizmann Institute and a Fogarty-Scholar-in-Residence at the National Institutes of Health (USA). Professor Gozes directs a very active research laboratory at Tel Aviv University and is mentoring and has mentored directly approximately 50 graduate students toward their MSc or PhD degrees.

The function of the RNA-binding protein TEL1 in moss reveals ancient regulatory mechanisms of shoot development.

PubMed

Vivancos, Julien; Spinner, Lara; Mazubert, Christelle; Charlot, Florence; Paquet, Nicolas; Thareau, Vincent; Dron, Michel; Nogué, Fabien; Charon, Céline

2012-03-01

The shoot represents the basic body plan in land plants. It consists of a repeated structure composed of stems and leaves. Whereas vascular plants generate a shoot in their diploid phase, non-vascular plants such as mosses form a shoot (called the gametophore) in their haploid generation. The evolution of regulatory mechanisms or genetic networks used in the development of these two kinds of shoots is unclear. TERMINAL EAR1-like genes have been involved in diploid shoot development in vascular plants. Here, we show that disruption of PpTEL1 from the moss Physcomitrella patens, causes reduced protonema growth and gametophore initiation, as well as defects in gametophore development. Leafy shoots formed on ΔTEL1 mutants exhibit shorter stems with more leaves per shoot, suggesting an accelerated leaf initiation (shortened plastochron), a phenotype shared with the Poaceae vascular plants TE1 and PLA2/LHD2 mutants. Moreover, the positive correlation between plastochron length and leaf size observed in ΔTEL1 mutants suggests a conserved compensatory mechanism correlating leaf growth and leaf initiation rate that would minimize overall changes in plant biomass. The RNA-binding protein encoded by PpTEL1 contains two N-terminus RNA-recognition motifs, and a third C-terminus non-canonical RRM, specific to TEL proteins. Removal of the PpTEL1 C-terminus (including this third RRM) or only 16-18 amino acids within it seriously impairs PpTEL1 function, suggesting a critical role for this third RRM. These results show a conserved function of the RNA-binding PpTEL1 protein in the regulation of shoot development, from early ancestors to vascular plants, that depends on the third TEL-specific RRM.

Computational Characterization of Electromagnetic Field Propagation in Complex Structures

DTIC Science & Technology

1998-04-10

34Computational characterization of electromagnetic field propagation in complex structures", DAAH01-91-D-ROOS D.O. 59. Dr. Michael Scalora performed the...Development, and Engineering Center, Bldg. 7804, Room 242 Redstone Arsenal, Alabama 35898-5248 USA Dr. Michael Scalora Quantum Optics Group Tel:(205...scheduled to appear. They are: (1) M. Scalora , J.P. Dowling, A.S. Manka, CM. Bowden, and J.W. Haus, Pulse Propagation Near Highly Reflective

CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.

PubMed

Horejsí, Zuzana; Takai, Hiroyuki; Adelman, Carrie A; Collis, Spencer J; Flynn, Helen; Maslen, Sarah; Skehel, J Mark; de Lange, Titia; Boulton, Simon J

2010-09-24

TEL2 interacts with and is essential for the stability of all phosphatidylinositol 3-kinase-related kinases (PIKKs), but its mechanism of action remains unclear. Here, we show that TEL2 is constitutively phosphorylated on conserved serines 487 and 491 by casein kinase 2 (CK2). Proteomic analyses establish that the CK2 phosphosite of TEL2 confers binding to the R2TP/prefoldin-like complex, which possesses chaperon/prefoldin activities required during protein complex assembly. The PIH1D1 subunit of the R2TP complex binds directly to the CK2 phosphosite of TEL2 in vitro and is required for the TEL2-R2TP/prefoldin-like complex interaction in vivo. Although the CK2 phosphosite mutant of TEL2 retains association with the PIKKs and HSP90 in cells, failure to interact with the R2TP/prefoldin-like complex results in instability of the PIKKs, principally mTOR and SMG1. We propose that TEL2 acts as a scaffold to coordinate the activities of R2TP/prefoldin-like and HSP90 chaperone complexes during the assembly of the PIKKs. Copyright © 2010 Elsevier Inc. All rights reserved.

Corrosion Behavior of Weathering Steel Under Thin Electrolyte Layer at Different Relative Humidity

NASA Astrophysics Data System (ADS)

Xia, Yan; Liu, Pan; Zhang, Jianqing; Cao, Fahe

2018-01-01

The corrosion behavior of weathering steel under thin electrolyte layer (TEL) at different relative humidity (RH) was investigated by cathodic polarization, electrochemical impedance spectroscopy, electrochemical noise, SEM/EDS, XRD and Raman spectroscopy. The results indicate that during the initial stage, the corrosion rate increases as the RH decreases when the initial thickness of TEL is above 100 μm. During the middle and final corrosion stages, the corrosion behavior of weathering steel is influenced by RH, the initial thickness of TEL and corrosion product. The TEL corrosion is divided into three types, and a weathering steel corrosion model under TEL and bulk solution is also proposed.

Ultra Fast, High Rep Rate, High Voltage Spark Gap Pulser

DTIC Science & Technology

1995-07-01

current rise time. The spark gap was designed to have a coaxial geometry reducing its inductance. Provisions were made to pass flowing gas between the...ULTRA FAST, HIGH REP RATE, HIGH VOLTAGE SPARK GAP PULSER Robert A. Pastore Jr., Lawrence E. Kingsley, Kevin Fonda, Erik Lenzing Electrophysics and...Modeling Branch AMSRL-PS-EA Tel.: (908)-532-0271 FAX: (908)-542-3348 U.S. Army Research Laboratory Physical Sciences Directorate Ft. Monmouth

Telmisartan prevents hepatic fibrosis and enzyme-altered lesions in liver cirrhosis rat induced by a choline-deficient L-amino acid-defined diet.

PubMed

Jin, Haiyan; Yamamoto, Naoki; Uchida, Koichi; Terai, Shuji; Sakaida, Isao

2007-12-28

Rennin-angiotensin system is involved in liver fibrogenesis through activating hepatic stellate cells (HSCs). Telmisartan (Tel) is an angiotensin II type 1 receptor antagonist, could function as a selective peroxisome proliferator-activated receptor gamma activator. Here we studied the effect of Tel on liver fibrosis, pre-neoplastic lesions in vivo and primary HSCs in vitro. In vivo study, we used the choline-deficient L-amino acid-defined (CDAA)-diet induced rat NASH model. The rats were fed the CDAA diet for 8 weeks to induce liver fibrosis and pre-neoplastic lesions, and then co-administrated with Tel for another 10 weeks. Tel prevented liver fibrogenesis and pre-neoplastic lesions by down-regulating TGFbeta1 and TIMP-1, 2 and increasing MMP-13 expression. Tel inhibited HSCs activation and proliferation. These results suggested that Tel could be a promising drug for NASH related liver fibrosis.

Reversible conversion of immortal human cells from telomerase-positive to telomerase-negative cells.

PubMed

Kumakura, Shin-ichi; Tsutsui, Takeo W; Yagisawa, Junko; Barrett, J Carl; Tsutsui, Takeki

2005-04-01

Immortal cell lines and tumors maintain their telomeres via the telomerase pathway or via a telomerase-independent pathway, referred to as alternative lengthening of telomeres (ALT). Here, we show the reversible conversion of the human papillomavirus type 16 E6-induced immortal human fibroblasts E6 Cl 6 from telomerase-positive (Tel(+)) to telomerase-negative (Tel(-)) cells. Tel(+) cells converted spontaneously to Tel(-) cells that reverted to Tel(+) cells following treatment with trichostatin A (TSA) and/or 5-aza-2'-deoxycytidine (5-AZC), which induced the reversion from complete to partial methylation of the CpG islands of the human telomerase reverse transcriptase (hTERT) promoter in Tel(-) E6 Cl 6 cells. Tel(-) E6 Cl 6 cells lacked the phenotypes characteristic of ALT cell lines such as very long and heterogenous telomeres and ALT-associated promyelocytic leukemia nuclear bodies (APB) but grew for >240 population doublings (PD) after they became telomerase negative. The ratios of histone H3 (H3) lysine (K) 9 methylation to each of H3-K4 methylation, H3-K9 acetylation, and H3-K14 acetylation of the chromatin containing the hTERT promoter in Tel(-) E6 Cl 6 cells and ALT cell lines were greater than those in Tel(+) cells and decreased following treatment with TSA and/or 5-AZC, inversely corresponding to telomerase activity. Our findings suggest the possibility that human tumors may be able to reversibly interconvert their telomere maintenance phenotypes by chromatin structure-mediated regulation of hTERT expression.

Expression patterns of TEL genes in Poaceae suggest a conserved association with cell differentiation.

PubMed

Paquet, Nicolas; Bernadet, Marie; Morin, Halima; Traas, Jan; Dron, Michel; Charon, Celine

2005-06-01

Poaceae species present a conserved distichous phyllotaxy (leaf position along the stem) and share common properties with respect to leaf initiation. The goal of this work was to determine if these common traits imply common genes. Therefore, homologues of the maize TERMINAL EAR1 gene in Poaceae were studied. This gene encodes an RNA-binding motif (RRM) protein, that is suggested to regulate leaf initiation. Using degenerate primers, one unique tel (terminal ear1-like) gene from seven Poaceae members, covering almost all the phylogenetic tree of the family, was identified by PCR. These genes present a very high degree of similarity, a much conserved exon-intron structure, and the three RRMs and TEL characteristic motifs. The evolution of tel sequences in Poaceae strongly correlates with the known phylogenetic tree of this family. RT-PCR gene expression analyses show conserved tel expression in the shoot apex in all species, suggesting functional orthology between these genes. In addition, in situ hybridization experiments with specific antisense probes show tel transcript accumulation in all differentiating cells of the leaf, from the recruitment of leaf founder cells to leaf margins cells. Tel expression is not restricted to initiating leaves as it is also found in pro-vascular tissues, root meristems, and immature inflorescences. Therefore, these results suggest that TEL is not only associated with leaf initiation but more generally with cell differentiation in Poaceae.

A telephonic intervention for promoting occupational re-integration in work-disabled individuals with musculoskeletal pain.

PubMed

Sullivan, Michael J L; Simon, Gregory

2012-06-01

The purpose of the present research was to examine the feasibility of a telephonic occupational rehabilitation program. A sample of 23 individuals with chronic musculoskeletal pain was enrolled in the telephonic version of the Progressive Goal Attainment Program (PGAP-Tel). The PGAP-Tel is a risk-targeted intervention designed to reduce pain-related disability consequent to musculoskeletal injury. Treatment outcomes of PGAP-Tel were compared to a group of individuals with chronic musculoskeletal pain, who participated in the face-to-face format of the PGAP. Results showed that PGAP-Tel was acceptable to the majority of participants (76%) to whom it was offered. There were indications that engagement and adherence issues were more problematic in PGAP-Tel than in the face-to-face intervention. Both groups showed comparable reductions in pain, depression, fear of symptom exacerbation, and self-reported disability. Participants in the face-to-face intervention showed greater reduction in catastrophic thinking than participants in PGAP-Tel. Finally, 26% of participants in PGAP-Tel had resumed some form of employment at treatment termination compared to 56% of the participants in the face-to-face intervention. Given the low cost of the PGAP-Tel intervention and the accessibility advantages of a telephonic delivery, this type of intervention might be an important resource for targeting occupational disability in rural or remote communities when face-to-face services are not available.

Involvement of intestinal permeability in the oral absorption of clarithromycin and telithromycin.

PubMed

Togami, Kohei; Hayashi, Yoshiaki; Chono, Sumio; Morimoto, Kazuhiro

2014-09-01

The involvement of intestinal permeability in the oral absorption of clarithromycin (CAM), a macrolide antibiotic, and telithromycin (TEL), a ketolide antibiotic, in the presence of efflux transporters was examined. In order independently to examine the intestinal and hepatic availability, CAM and TEL (10 mg/kg) were administered orally, intraportally and intravenously to rats. The intestinal and hepatic availability was calculated from the area under the plasma concentration-time curve (AUC) after administration of CAM and TEL via different routes. The intestinal availabilities of CAM and TEL were lower than their hepatic availabilities. The intestinal availability after oral administration of CAM and TEL increased by 1.3- and 1.6-fold, respectively, after concomitant oral administration of verapamil as a P-glycoprotein (P-gp) inhibitor. Further, an in vitro transport experiment was performed using Caco-2 cell monolayers as a model of intestinal epithelial cells. The apical-to-basolateral transport of CAM and TEL through the Caco-2 cell monolayers was lower than their basolateral-to-apical transport. Verapamil and bromosulfophthalein as a multidrug resistance-associated proteins (MRPs) inhibitor significantly increased the apical-to-basolateral transport of CAM and TEL. Thus, the results suggest that oral absorption of CAM and TEL is dependent on intestinal permeability that may be limited by P-gp and MRPs on the intestinal epithelial cells. Copyright © 2014 John Wiley & Sons, Ltd.

The Knock-Limited Performance of Fuel Blends Containing Aromatics V : N-Propylbenzene, N-Butylbenzene, Isobutylbenzene, M-Xylene, and 1-Isopropyl-4-Methylbenzene

NASA Technical Reports Server (NTRS)

Meyer, Carl L.; Branstetter, J. Robert

1946-01-01

Results are reported of knock-limited tests of five aromatics, each individually blended with selected base fuels and tested with and without TEL, using 17.6, F-4, and F-3 small-scale engines. The five aromatics rated in the following order of decreasing antiknock effectiveness at fuel/air ratio 0.10: m-xylene, 1-isopropyl-4-methylbenzene, n-propylbenzene, isobutylbenzene, and n-butylbenzene.

TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Hong-Bao; Li, Xiang; Huo, Chan-Juan

Previous findings from our laboratory and others indicate that the main therapeutic effect of angiotensin II type 1 receptor (AT1-R) antagonists is to decrease blood pressure and exert anti-inflammatory effects in the cardiovascular system. In this study, we determined whether AT1-R antagonist telmisartan within the hypothalamic paraventricular nucleus (PVN) attenuates hypertension and hypothalamic inflammation via both the TLR4/MyD88/NF-κB signaling pathway and peroxisome proliferator-activated receptor-γ (PPAR-γ) in the PVN in hypertensive rats. Spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats were treated for 4 weeks through bilateral PVN infusion with the AT1-R antagonist telmisartan (TEL, 10 μg/h), or losartanmore » (LOS, 20 μg/h), or the PPAR-γ antagonist GW9662 (GW, 100 μg/h), or vehicle via osmotic minipump. Mean arterial pressure (MAP) was recorded by a tail-cuff occlusion method. PVN tissue and blood were collected for the measurement of AT1-R, PPAR-γ, pro-inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6), inducible nitric oxide synthase (iNOS), TLR4, MyD88, nuclear factor-kappa B (NF-κB) activity and plasma norepinephrine (NE), respectively. Hypertensive rats exhibited significantly higher level of AT1-R and lower level of PPAR-γ in the PVN. PVN treatment with TEL attenuated MAP, improved cardiac hypertrophy, reduced TNF-α, IL-1β, IL-6, iNOS levels, and plasma NE in SHR but not in WKY rats. These results were associated with reduced TLR4, MyD88 and NF-κB levels and increased PPAR-γ level in the PVN of hypertensive rats. Our findings suggest that TLR4/MyD88/NF-κB signaling and PPAR-γ within the PVN are involved in the beneficial effects of telmisartan in hypertension. - Highlights: • PVN infusion of TEL in spontaneously hypertensive rats is reported. • PVN infusion of TEL attenuates hypertension and proinflammatory cytokines in PVN. • PVN blockade of AT1-R attenuates sympathoexcitation and cardiac hypertrophy. • TLR4/MyD88/NF-κB signaling and PPAR-γ in PVN are involved in the effects of TEL.« less

A preliminary evaluation of sediment quality assessment values for freshwater ecosystems

USGS Publications Warehouse

Smith, Sherri L.; MacDonald, Donald D.; Keenleyside, Karen A.; Ingersoll, Christopher G.; Field, L. Jay

1996-01-01

Sediment quality assessment values were developed using a weight of evidence approach in which matching biological and chemical data from numerous modelling, laboratory, and field studies performed on freshwater sediments were compiled and analyzed. Two assessment values (a threshold effect level (TEL) and a probable effect level(PEL)) were derived for 23 substances, including eight trace metals, six individual polycyclic aromatic hydrocarbons (PAHs), total polychlorinated biphenyls (PCBs), and eight pesticides. The two values defined three ranges of chemical concentrations; those that were (1) rarely, (2) occasionally, and (3) frequently associated with adverse biological effects. An evaluation of the percent incidence of adverse biological effects within the three concentration ranges indicated that the reliability of the TELs (i.e., the degree to which the TELs represent concentrations within the data set below which adverse effects rarely occur) was consistently good. However, this preliminary evaluation indicated that most of the PELs were less reliable (i.e., they did not adequately represent concentrations within the data set above which adverse effects frequently occur). Nonetheless, these values were often comparable to other biological effects-based assessment values (which were themselves reliable), which increased the level of confidence that could be placed in our values. This method is being used as a basis for developing national sediment quality guidelines for freshwater systems in Canada and sediment effect concentrations as part of the Assessment and Remediation of Contaminated Sediments (ARCS) program in the Great Lakes.

[Simplicia and medical containers from the Jesuit pharmacy in Telč].

PubMed

Hamrlová, Anna

2017-01-01

The Jesuit pharmacy in Telč was founded after 1657 within the premises of the Jesuit cloister; it survived the dissolution of Jesuits in 1773 and thanks to its purchase by the last pharmacist Ignac Lyro it was relocated to one of the houses in the square. During the stocktaking of the property and its sale, a detailed inventory of pharmacy equipment was recorded, including cabinets, laboratory tools, ingredients or drugs. The inventory is divided into parts of ingredients and prepared medications, the last lists recording the tools and containers for its preparation, production and preservation. The ingredients contain various parts of plants, minerals, precious stones or even parts of animals. The list is written mainly in the alphabetical order, in some cases with specified types of groups. Every item is provided with information about its price and quantity. Many ingredients originated from overseas countries, the areas of Jesuit missionary activities. Of the former rich equipment, only three pharmacy cabinets and a few containers, mainly veneer boxes and ceramic drug jars, have survived. All these parts together with the inventory give us a comparatively clear notion about the equipment and even facilities of the Jesuit apothecary in Telč, which sold items from different parts of the world. The Jesuit convent seems to be an important centre for town inhabitants not only in the 18th century; its legacy has remained in the local pharmacy till today.Key words: pharmacy Societas Jesus 18th century medications medical containers.

Combining ultrasonography and noncontrast helical computerized tomography to evaluate Holmium laser lithotripsy

PubMed Central

Mi, Jia; Li, Jie; Zhang, Qinglu; Wang, Xing; Liu, Hongyu; Cao, Yanlu; Liu, Xiaoyan; Sun, Xiao; Shang, Mengmeng; Liu, Qing

2016-01-01

Abstract The purpose of the study was to establish a mathematical model for correlating the combination of ultrasonography and noncontrast helical computerized tomography (NCHCT) with the total energy of Holmium laser lithotripsy. In this study, from March 2013 to February 2014, 180 patients with single urinary calculus were examined using ultrasonography and NCHCT before Holmium laser lithotripsy. The calculus location and size, acoustic shadowing (AS) level, twinkling artifact intensity (TAI), and CT value were all documented. The total energy of lithotripsy (TEL) and the calculus composition were also recorded postoperatively. Data were analyzed using Spearman's rank correlation coefficient, with the SPSS 17.0 software package. Multiple linear regression was also used for further statistical analysis. A significant difference in the TEL was observed between renal calculi and ureteral calculi (r = –0.565, P < 0.001), and there was a strong correlation between the calculus size and the TEL (r = 0.675, P < 0.001). The difference in the TEL between the calculi with and without AS was highly significant (r = 0.325, P < 0.001). The CT value of the calculi was significantly correlated with the TEL (r = 0.386, P < 0.001). A correlation between the TAI and TEL was also observed (r = 0.391, P < 0.001). Multiple linear regression analysis revealed that the location, size, and TAI of the calculi were related to the TEL, and the location and size were statistically significant predictors (adjusted r2 = 0.498, P < 0.001). A mathematical model correlating the combination of ultrasonography and NCHCT with TEL was established; this model may provide a foundation to guide the use of energy in Holmium laser lithotripsy. The TEL can be estimated by the location, size, and TAI of the calculus. PMID:27930563

Staging of Macular Telangiectasia: Power-Doppler Optical Coherence Tomography and Macular Pigment Optical Density

PubMed Central

Chin, Eric K.; Kim, Dae Yu; Hunter, Allan A.; Pilli, Suman; Wilson, Machelle; Zawadzki, Robert J.; Werner, John S.; Park, Susanna S.

2013-01-01

Purpose. Two methods were used to study the stages of macular telangiectasia (MacTel): Power-Doppler optical coherence tomography (PD-OCT), which allows imaging of the retinal circulation in three dimensions, and macular pigment optical density (MPOD), which quantifies the distribution of macular carotenoids. Methods. Among 49 patients with MacTel identified, 12 eyes (6 patients) with MacTel and 7 age-matched control eyes (7 patients) were imaged with a custom-built Fourier-domain OCT instrument to acquire PD-OCT images. MPOD was measured using heterochromatic flicker photometry in 10 eyes (5 patients) with MacTel and compared with 44 age-matched control eyes (44 patients). Clinical staging of MacTel was based on best-corrected visual acuity, fundus biomicroscopy, fluorescein angiography, and OCT. Results. Stage 1 eyes (n = 2) had subtle punctate vascular signal confined to the inner portion of the outer plexiform layer (OPL) on PD-OCT. Stage 2 (n = 2) showed larger oblique vascular signal extending into deeper OPL. Stage 3 (n = 5) had disruption of outer retinal layers with abnormal vasculature extending into the outer nuclear layer. Stage 4 (n = 3) showed diffuse blurring of the retinal layers with vascular channels extending the full thickness of the retina. MPOD values in four eyes with stage 1 or 2 MacTel correlated well with age-matched controls. Six eyes with stage 3 or 4 MacTel had loss of MPOD especially at the fovea. Conclusions. PD-OCT shows penetration of the retinal capillaries into the deeper retinal layers in early stages of MacTel, with full thickness vascular proliferation in advanced disease. MPOD is commonly depleted but may appear normal in early stage MacTel. PMID:23716628

The TEL-AML1 fusion protein of acute lymphoblastic leukemia modulates IRF3 activity during early B-cell differentiation.

PubMed

de Laurentiis, A; Hiscott, J; Alcalay, M

2015-12-03

The t(12;21) translocation is the most common genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) and gives rise to the TEL-AML1 fusion gene. Many studies on TEL-AML1 describe specific properties of the fusion protein, but a thorough understanding of its function is lacking. We exploited a pluripotent hematopoietic stem/progenitor cell line, EML1, and generated a cell line (EML-TA) stably expressing the TEL-AML1 fusion protein. EML1 cells differentiate to mature B-cells following treatment with IL7; whereas EML-TA display an impaired differentiation capacity and remain blocked at an early stage of maturation. Global gene expression profiling of EML1 cells at different stages of B-lymphoid differentiation, compared with EML-TA, identified the interferon (IFN)α/β pathway as a primary target of repression by TEL-AML1. In particular, expression and phosphorylation of interferon-regulatory factor 3 (IRF3) was decreased in EML-TA cells; strikingly, stable expression of IRF3 restored the capacity of EML-TA cells to differentiate into mature B-cells. Similarly, IRF3 silencing in EML1 cells by siRNA was sufficient to block B-lymphoid differentiation. The ability of TEL-AML1 to block B-cell differentiation and downregulate the IRF3-IFNα/β pathway was confirmed in mouse and human primary hematopoietic precursor cells (Lin- and CD34+ cells, respectively), and in a patient-derived cell line expressing TEL-AML1 (REH). Furthermore, treatment of TEL-AML1 expressing cells with IFNα/β was sufficient to overcome the maturation block. Our data provide new insight on TEL-AML1 function and may offer a new therapeutic opportunity for B-ALL.

In vitro corrosion of pure magnesium and AZ91 alloy—the influence of thin electrolyte layer thickness

PubMed Central

Zeng, Rong-Chang; Qi, Wei-Chen; Zhang, Fen; Li, Shuo-Qi

2016-01-01

In vivo degradation predication faces a huge challenge via in vitro corrosion test due to the difficulty for mimicking the complicated microenvironment with various influencing factors. A thin electrolyte layer (TEL) cell for in vitro corrosion of pure magnesium and AZ91 alloy was presented to stimulate the in vivo corrosion in the micro-environment built by the interface of the implant and its neighboring tissue. The results demonstrated that the in vivo corrosion of pure Mg and the AZ91 alloy was suppressed under TEL condition. The AZ91 alloy was more sensitive than pure Mg to the inhibition of corrosion under a TEL thickness of less than 200 µm. The TEL thickness limited the distribution of current, and thus localized corrosion was more preferred to occur under TEL condition than in bulk solution. The TEL cell might be an appropriate approach to simulating the in vivo degradation of magnesium and its alloys. PMID:26816655

Telmisartan prevents hepatic fibrosis and enzyme-altered lesions in liver cirrhosis rat induced by a choline-deficient L-amino acid-defined diet

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jin Haiyan; Department of Gastroenterology and Hepatology, Yanbian University Hospital, Yanji, Jilin; Yamamoto, Naoki

2007-12-28

Rennin-angiotensin system is involved in liver fibrogenesis through activating hepatic stellate cells (HSCs). Telmisartan (Tel) is an angiotensin II type 1 receptor antagonist, could function as a selective peroxisome proliferator-activated receptor {gamma} activator. Here we studied the effect of Tel on liver fibrosis, pre-neoplastic lesions in vivo and primary HSCs in vitro. In vivo study, we used the choline-deficient L-amino acid-defined (CDAA)-diet induced rat NASH model. The rats were fed the CDAA diet for 8 weeks to induce liver fibrosis and pre-neoplastic lesions, and then co-administrated with Tel for another 10 weeks. Tel prevented liver fibrogenesis and pre-neoplastic lesions bymore » down-regulating TGF{beta}1 and TIMP-1, 2 and increasing MMP-13 expression. Tel inhibited HSCs activation and proliferation. These results suggested that Tel could be a promising drug for NASH related liver fibrosis.« less

Framework of Quality Assurance of TEL Integration into an Educational Organization

ERIC Educational Resources Information Center

Volungeviciene, Airina; Tereseviciene, Margarita; Tait, Alan

2014-01-01

This research paper addresses the issues of integration of technology enhanced learning (TEL) into an educational organization. Good practice experience cannot be directly transferred to new organisations due to different contextual conditions. The TEL integration depends significantly upon a very rapid development of services and information…

Toward a Personal Learning Environment Framework

ERIC Educational Resources Information Center

Chatti, Mohamed Amine; Agustiawan, Mohammad Ridwan; Jarke, Matthias; Specht, Marcus

2010-01-01

Over the past decade, it has been argued that technology-enhanced learning (TEL) could respond to the needs of the new knowledge society and transform learning. However, despite isolated achievements, TEL has not succeeded in revolutionizing education and learning processes. Most current TEL initiatives still take a centralized technology-push…

What Is High School Economics? TEL Revision and Pretest Findings.

ERIC Educational Resources Information Center

Walstad, William B.; Soper, John C.

1988-01-01

Argues there is limited research data about student knowledge of economic concepts at the secondary school education level. Describes the development, validation, and national norming of the revised Test of Economic Literacy (TEL) and presents findings from the 1986 pretest analysis of the revised TEL. (BSR)

Earth observations taken by the Expedition One crew

NASA Image and Video Library

2000-12-28

ISS001-E-5981 (28 December 2000) --- A near-vertical digital still image from the International Space Station (ISS) features Tel Aviv-Yafo, Israel. A small section of the Mediterranean Sea coastline is at bottom left. One of the Expedition One crew members used an extender on a 400mm lens to provide detail in the image. Onboard the outpost for the first habitation tour were astronaut William M. (Bill) Shepherd, commander; along with cosmonauts Yuri P. Gidzenko, Soyuz commander; and Sergei K. Krikalev, flight engineer.

Methylation of 23S rRNA Nucleotide G748 by RlmAII Methyltransferase Renders Streptococcus pneumoniae Telithromycin Susceptible

PubMed Central

Sato, Yoshiharu; Shoji, Tatsuma; Yamamoto, Tomoko

2013-01-01

Several posttranscriptional modifications of bacterial rRNAs are important in determining antibiotic resistance or sensitivity. In all Gram-positive bacteria, dimethylation of nucleotide A2058, located in domain V of 23S rRNA, by the dimethyltransferase Erm(B) results in low susceptibility and resistance to telithromycin (TEL). However, this is insufficient to produce high-level resistance to TEL in Streptococcus pneumoniae. Inactivation of the methyltransferase RlmAII, which methylates the N-1 position of nucleotide G748, located in hairpin 35 of domain II of 23S rRNA, results in increased resistance to TEL in erm(B)-carrying S. pneumoniae. Sixteen TEL-resistant mutants (MICs, 16 to 32 μg/ml) were obtained from a clinically isolated S. pneumoniae strain showing low TEL susceptibility (MIC, 2 μg/ml), with mutation resulting in constitutive dimethylation of A2058 because of nucleotide differences in the regulatory region of erm(B) mRNA. Primer extension analysis showed that the degree of methylation at G748 in all TEL-resistant mutants was significantly reduced by a mutation in the gene encoding RlmAII to create a stop codon or change an amino acid residue. Furthermore, RNA footprinting with dimethyl sulfate and a molecular modeling study suggested that methylation of G748 may contribute to the stable interaction of TEL with domain II of 23S rRNA, even after dimethylation of A2058 by Erm(B). This novel finding shows that methylation of G748 by RlmAII renders S. pneumoniae TEL susceptible. PMID:23716046

Methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible.

PubMed

Takaya, Akiko; Sato, Yoshiharu; Shoji, Tatsuma; Yamamoto, Tomoko

2013-08-01

Several posttranscriptional modifications of bacterial rRNAs are important in determining antibiotic resistance or sensitivity. In all Gram-positive bacteria, dimethylation of nucleotide A2058, located in domain V of 23S rRNA, by the dimethyltransferase Erm(B) results in low susceptibility and resistance to telithromycin (TEL). However, this is insufficient to produce high-level resistance to TEL in Streptococcus pneumoniae. Inactivation of the methyltransferase RlmA(II), which methylates the N-1 position of nucleotide G748, located in hairpin 35 of domain II of 23S rRNA, results in increased resistance to TEL in erm(B)-carrying S. pneumoniae. Sixteen TEL-resistant mutants (MICs, 16 to 32 μg/ml) were obtained from a clinically isolated S. pneumoniae strain showing low TEL susceptibility (MIC, 2 μg/ml), with mutation resulting in constitutive dimethylation of A2058 because of nucleotide differences in the regulatory region of erm(B) mRNA. Primer extension analysis showed that the degree of methylation at G748 in all TEL-resistant mutants was significantly reduced by a mutation in the gene encoding RlmA(II) to create a stop codon or change an amino acid residue. Furthermore, RNA footprinting with dimethyl sulfate and a molecular modeling study suggested that methylation of G748 may contribute to the stable interaction of TEL with domain II of 23S rRNA, even after dimethylation of A2058 by Erm(B). This novel finding shows that methylation of G748 by RlmA(II) renders S. pneumoniae TEL susceptible.

Direct Commercial and Foreign Military Sales: Chemical Defense Equipment, an Introductory Brochure

DTIC Science & Technology

1991-06-01

60128 CGHCH CM ______________Fax: (86] (028)583-520 COLOMBIA Bogota Tel: [57](1)285-1300/1688 Telex: 44843 ______________Fax: (5711 (1)288-5687...CONSULATES Palermo Tel: (39](91)343-532 Telex: 910313 USA CON I Commercial Section: (39] (91)346-036, 345-1923 Fax: (39] (91)343-546 Florence Tel: [39

Ultrastructural and clinical evidence of subretinal debris accumulation in type 2 macular telangiectasia.

PubMed

Cherepanoff, Svetlana; Killingsworth, Murray C; Zhu, Meidong; Nolan, Timothy; Hunyor, Alex P; Young, Stephanie H; Hageman, Gregory S; Gillies, Mark C

2012-11-01

To describe subretinal debris found on ultrastructural examination in an eye with macular telangiectasia (MacTel) type 2 and on optical coherence tomography (OCT) in a subset of patients with MacTel type 2. Blocks from the mid-periphery and temporal perifovea of an eye with clinically documented MacTel type 2 were examined with electron microscopy (EM). Cases came from the Sydney centre of the MacTel project and the practices of the authors. On EM examination, subretinal debris was found in the perifovea with accumulation of degenerate photoreceptor elements in the subretinal space. Despite the substantial subretinal debris, there was minimal retinal pigment epithelial (RPE) reaction. Focal defects were seen in the inner limiting membrane in the perifovea. Of the 65 Sydney MacTel project participants, three (5%) had prominent yellow material at the fovea. OCT revealed smooth mounds between the RPE and the ellipsoid region. The material was hyperautofluorescent. This study suggests that subretinal accumulation of photoreceptor debris may be a feature of MacTel type 2. Ultrastructural and OCT evidence of disease beyond the vasculature, involving photoreceptors and Muller cells, is presented.

A pilot randomized controlled trial of telephone intervention to increase Breast Cancer Screening uptake in socially deprived areas in Scotland (TELBRECS).

PubMed

Chambers, Julie A; Gracie, Kerry; Millar, Rosemary; Cavanagh, Julie; Archibald, Debbie; Cook, Alan; O'Carroll, Ronan E

2016-09-01

To determine whether a brief telephone support intervention could increase breast cancer screening uptake among lower socio-demographic women in Scotland, via eliciting and addressing barriers to screening attendance. In a pilot randomized controlled trial, participants receiving a reminder letter for a missed screening appointment (February-June 2014) were randomized to four arms: No telephone call (control), Simple telephone reminder (TEL), Telephone support (TEL-SUPP), or Telephone support plus anticipated regret (TEL-SUPP-AR). Primary outcomes were making an appointment and attending breast screening. Of 856 women randomized and analysed on intention-to-treat basis, compared with controls, more women in the telephone intervention groups made an appointment (control: 8.8%, TEL: 20.3%, TEL-SUPP: 14.1%; TEL-SUPP-AR: 16.8%, χ(2)(3) = 12.0, p = .007) and attended breast screening (control: 6.9%, TEL: 16.5%, TEL-SUPP: 11.3%; TEL-SUPP-AR: 13.1%, χ(2)(3) = 9.8, p = .020). Of 559 women randomized to the three telephone groups, 404 were successfully contacted and 247 participated in the intervention. Intervention participants (ie. per protocol analysis) were more likely to make (17% versus 10%, χ(2)(1) = 7.0, p = .008) and attend (13% versus 7%, χ(2)(1) = 5.5, p = .019) an appointment than non-participants, but there were no differences in attendance between the three telephone groups. A simple telephone reminder doubled attendance at breast screening in women from lower socio-demographic areas who had not attended their initial appointment, compared with a reminder letter only (odds ratio 2.12, 95% CI (1.2, 3.8)). However, contacting women proved problematic and there was no additional effect of telephone support or anticipated regret. © The Author(s) 2015.

The status of dermatoglyphics as a biomarker of Tel Hashomer camptodactyly syndrome: a review of the literature.

PubMed

Wijerathne, Buddhika T B; Meier, Robert J; Agampodi, Suneth B

2016-09-20

Tel Hashomer camptodactyly syndrome is a rare disease and only a few cases have been reported. Dermatoglyphics potentially provide relevant phenotypic biomarkers that were initially noted as a vital clinical feature of this disease. Dermatoglyphics possibly can indicate growth disturbances that took place during early fetal development at the time when epidermal ridges were being formed into discernable patterns. Consequently, these intrauterine effects might well have occurred in association with the expression of the Tel Hashomer camptodactyly syndrome. Therefore, this review was undertaken to provide, as far as we know, the first attempt to broadly assess dermatoglyphic features that are connected with the Tel Hashomer camptodactyly syndrome. If a developmental association between dermatoglyphics and Tel Hashomer camptodactyly can be firmly established, this would probably document that Tel Hashomer camptodactyly disease has its origins during the early fetal period. A systematic literature search was conducted using articles from PubMed (Medline), POPLINE, Trip Database, Cochrane Library, and gray literature up to 31 March 2015. The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Fourteen relevant publications were included in the review. There were 23 cases of patients with Tel Hashomer camptodactyly syndrome that were described in these published articles. We reviewed the dermatoglyphics of 21 available cases out of all of the published and electronically available cases of Tel Hashomer camptodactyly. Eight cases reported whorls to be the most common digital pattern with an expected rise of ridge count. Two cases show significantly high frequencies of arch patterns. Further, there were increased numbers of palmar creases, along with abnormal flexion creases or other palmar dermatoglyphic abnormalities reported in all cases. This review highlighted the desirability of thoroughly observing and recording dermatoglyphic features when reporting on future patients with Tel Hashomer camptodactyly syndrome, in conjunction with carrying out modern molecular methods.

A holistic model for evaluating the impact of individual technology-enhanced learning resources.

PubMed

Pickering, James D; Joynes, Viktoria C T

2016-12-01

The use of technology within education has now crossed the Rubicon; student expectations, the increasing availability of both hardware and software and the push to fully blended learning environments mean that educational institutions cannot afford to turn their backs on technology-enhanced learning (TEL). The ability to meaningfully evaluate the impact of TEL resources nevertheless remains problematic. This paper aims to establish a robust means of evaluating individual resources and meaningfully measure their impact upon learning within the context of the program in which they are used. Based upon the experience of developing and evaluating a range of mobile and desktop based TEL resources, this paper outlines a new four-stage evaluation process, taking into account learner satisfaction, learner gain, and the impact of a resource on both the individual and the institution in which it has been adapted. A new multi-level model of TEL resource evaluation is proposed, which includes a preliminary evaluation of need, learner satisfaction and gain, learner impact and institutional impact. Each of these levels are discussed in detail, and in relation to existing TEL evaluation frameworks. This paper details a holistic, meaningful evaluation model for individual TEL resources within the specific context in which they are used. It is proposed that this model is adopted to ensure that TEL resources are evaluated in a more meaningful and robust manner than is currently undertaken.

Chromosomal instability in enterohaemorrhagic Escherichia coli O157:H7: impact on adherence, tellurite resistance and colony phenotype

PubMed Central

Bielaszewska, Martina; Middendorf, Barbara; Tarr, Phillip I; Zhang, Wenlan; Prager, Rita; Aldick, Thomas; Dobrindt, Ulrich; Karch, Helge; Mellmann, Alexander

2011-01-01

Tellurite (Tel) resistant enterohaemorrhagic Escherichia coli (EHEC) O157:H7 is a global pathogen. In strain EDL933 Tel resistance (TelR) is encoded by duplicate ter cluster in O islands (OI) 43 and 48, which also harbour iha, encoding the adhesin and siderophore receptor Iha. We identified five EHEC O157:H7 strains that differentiate into large (L) colonies and small (S) colonies with high and low Tel minimal inhibitory concentrations (MICs) respectively. S colonies (Tel-MICs ≤ 4 µg ml−1) sustained large internal deletions within the TelR OIs via homologous recombination between IS elements and lost ter and iha. Moreover, complete excision of the islands occurred by site-specific recombination between flanking direct repeats. Complete excision of OI 43 and OI 48 occurred in 1.81 × 10−3 and 1.97 × 10−4 cells in culture, respectively; internal deletion of OI 48 was more frequent (9.7 × 10−1 cells). Under iron limitation that promotes iha transcription, iha-negative derivatives adhered less well to human intestinal epithelial cells and grew slower than did their iha-positive counterparts. Experiments utilizing iha deletion and complementation mutants identified Iha as the major factor responsible for these phenotypic differences. Spontaneous deletions affecting TelR OIs contribute to EHEC O157 genome plasticity and might impair virulence and/or fitness. PMID:21299654

Critical Perspectives on TEL: Art and Design Education, Theory, Communities and Space

ERIC Educational Resources Information Center

Sclater, Madeleine; Lally, Vic

2016-01-01

This paper explores three themes, emerging from the Inter-Life project, an Art and Design education and social skills project set in a virtual world. We argue that they connect with the concerns raised by critical Technology-Enhanced Learning (TEL) researchers at the Alpine Rendezvous workshop entitled "TEL: the Crisis and the Response."…

A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: characterization and in vitro/in vivo evaluation.

PubMed

Song, Chung Kil; Balakrishnan, Prabagar; Shim, Chang-Koo; Chung, Suk-Jae; Chong, Saeho; Kim, Dae-Duk

2012-04-01

This study describes a novel carrier, transethosome, for enhanced skin delivery of voriconazole. Transethosomes (TELs) are composed of phospholipid, ethanol, water and edge activator (surfactants) or permeation enhancer (oleic acid). Characterization of the TELs was based on results from recovery, particle size, transmission electron microscopy (TEM), zeta potential and elasticity studies. In addition, skin permeation profile was obtained using static vertical diffusion Franz cells and hairless mouse skin treated with TELs containing 0.3% (w/w) voriconazole, and compared with those of ethosomes (ELs), deformable liposomes (DLs), conventional liposomes (CLs) and control (polyethylene glycol, PG) solutions. The recovery of the studied vesicles was above 90% in all vesicles, as all of them contained ethanol (7-30%). There was no significant difference in the particles size of all vesicles. The TEM study revealed that the TELs were in irregular spherical shape, implying higher fluidity due to perturbed lipid bilayer compared to that of other vesicles which were of spherical shape. The zeta potential of vesicles containing sodium taurocholate or oleic acid showed higher negative value compared to other vesicles. The elasticities of ELs and TELs were much higher than that of CLs and DLs. Moreover, TELs dramatically enhanced the skin permeation of voriconazole compared to the control and other vesicles (p<0.05). Moreover, the TELs enhanced both in vitro and in vivo skin deposition of voriconazole in the dermis/epidermis region compared to DLs, CLs and control. Therefore, based on the current study, the novel carrier TELs could serve as an effective dermal delivery for voriconazole. Copyright © 2011 Elsevier B.V. All rights reserved.

Spectroscopic study of fluorescent probes based on G-quadruplex oligonucleotides labeled with ethynylpyrenyldeoxyuridine.

PubMed

Switalska, Angelika; Kierzek, Ryszard; Dembska, Anna; Juskowiak, Bernard

2017-12-01

The design, synthesis, and spectral properties of four pyrene labeled oligonucleotide probes with G-quadruplex structure (Tel22-Tpy, Tel22-Upy, Tel22-6Upy, Tel22-18Upy) based on the 22-mer human telomeric sequence (Tel22) have been reported. Pyrene labels in the form of ethynylpyrenyldeoxyuridine have been inserted efficiently into oligodeoxynucleotides probes using phosphoramidite chemistry. The probes exhibited abilities to fold into G-quadruplex structures and to bind metal cations (Na + and K + ). Folding properties of probes and their spectral behavior were examined by recording the UV-vis, fluorescence, and CD spectra as well as by analyzing melting profiles. Fluorescence characteristics and G-quadruplex folding of probes were also studied at the interface of cationic dioctadecyldimethylammonium bromide (DODAB) monolayer. Investigations included film balance measurements (π-A isotherms) and fluorescence spectra recording using a fiber optic accessory interfaced with a spectrofluorimeter. Copyright © 2017 Elsevier B.V. All rights reserved.

A Report Card on the Economic Literacy of U.S. High School Students.

ERIC Educational Resources Information Center

Walstad, William B.; Soper, John C.

A study of over 3,000 U.S. high school students who took the Test of Economic Literacy (TEL) in 1986 reveals a lack of basic understanding in the four basic TEL concept clusters of fundamental economics, microeconomics, macroeconomics, and international economics. The TEL was administered pre- and posttest where students were enrolled in one of…

Evidence-Based Principles for Using Technology-Enhanced Learning in the Continuing Professional Development of Health Professionals.

PubMed

Scott, Karen M; Baur, Louise; Barrett, Jenny

2017-01-01

Increasingly, health professional training involves the use of educational technologies through what is broadly termed "Technology-Enhanced Learning" (TEL). TEL includes hardware, such as computers and mobile devices, and software, such as software applications (apps), learning management systems, and discussion boards. For many years, TEL has formed an integral part of health professional programs and is growing in acceptance, if not expectation, in postgraduate training and continuing education. TEL generally aims to be flexible, engaging, learner focused and interactive, and may involve collaboration and communication. It offers many benefits for learning and teaching, whether used on its own or in conjunction with face-to-face teaching through blended learning. The ubiquity of mobile devices in clinical settings means TEL is ideal for busy clinicians, both as learners and teachers. TEL enables participants to learn at a time and place that is convenient to them, so learners living in geographically dispersed locations can access standardized courses. To realize these potential benefits, we recommend that those developing TEL programs for health professionals take a systematic approach to planning, development, implementation, and evaluation. To that end, we propose 10 principles: clarify purpose and conduct a needs assessment; allocate adequate time and technology; incorporate proven approaches to improve learning; consider the need for a skills component; enable interaction between learners and with others; create different resources for different groups; pilot before implementing; incorporate measures to retain learners; provide opportunities for revision to aid retention; and evaluate learning outcomes, not just satisfaction.

TEL/AML1 positivity in childhood ALL: average or better prognosis? Czech Paediatric Haematology Working Group.

PubMed

Zuna, J; Hrusák, O; Kalinová, M; Muzíková, K; Starý, J; Trka, J

1999-01-01

The presence of TEL/AML1 fusion gene in childhood acute lymphoblastic leukaemia (ALL) defines a subgroup of patients with better than average outcome. However, the prognostic significance of this aberration has recently been disputed by the Berlin-Frankfurt-Münster (BFM) study group due to its relatively high incidence found in relapsed patients (19.6% and 21.9%, in two cohorts). In contrast, only four out of 45 (8.9%) unselected relapsed patients (all of whom had been treated according to BFM protocols) in the Czech Republic carry this fusion. From March 1995 to June 1998, 41 out of 190 (21.6%) newly diagnosed children with ALL were TEL/AML1-positive. There is a statistically significant difference between the incidence of TEL/AML1 fusion at diagnosis and at relapse within our group (P = 0.035). Interim analysis of the minimal residual disease (MRD) detection shows heterogeneity within the group of newly diagnosed TEL/AML1-positive leukaemias--10 out of 24 patients tested at the end of induction therapy had detectable levels of MRD. However, only one of these patients reached relapse-predictive level (10(-3)) of MRD. In conclusion, we corroborate low frequency of TEL/AML1 positivity among relapsed patients with ALL among Czech children who are treated by the BFM protocols. Moreover, we demonstrate different patterns of bone marrow clean-up in TEL/AML1-positive patients.

Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia

PubMed Central

Ford, Anthony M.; Bennett, Caroline A.; Price, Cathy M.; Bruin, M. C. A.; Van Wering, Elisabeth R.; Greaves, Mel

1998-01-01

The TEL (ETV6)−AML1 (CBFA2) gene fusion is the most common reciprocal chromosomal rearrangement in childhood cancer occurring in ≈25% of the most predominant subtype of leukemia— common acute lymphoblastic leukemia. The TEL-AML1 genomic sequence has been characterized in a pair of monozygotic twins diagnosed at ages 3 years, 6 months and 4 years, 10 months with common acute lymphoblastic leukemia. The twin leukemic DNA shared the same unique (or clonotypic) but nonconstitutive TEL-AML1 fusion sequence. The most plausible explanation for this finding is a single cell origin of the TEL-AML fusion in one fetus in utero, probably as a leukemia-initiating mutation, followed by intraplacental metastasis of clonal progeny to the other twin. Clonal identity is further supported by the finding that the leukemic cells in the two twins shared an identical rearranged IGH allele. These data have implications for the etiology and natural history of childhood leukemia. PMID:9539781

A Description on the Second Dataset of the U.S. Army Research Laboratory Force Protection Surveillance System

DTIC Science & Technology

2007-08-01

Powder Mill Road, Adelphi, MD 20783, TEL - 301-394-1677, FAX - 301-394-5234, or e -mail achan@arl.army.mil. 13 Appendix A. Ground-truth Information...Rd FT Belvoir VA 22060-5806 Commander US Army RDECOM 1 HC ATTN AMSRD AMR W C McCorkle 5400 Fowler Rd Redstone Arsenal AL 35898-5000 18...Picatinney Arsenal NJ 07806-5000 US Army RDECOM TARDEC 1 HC ATTN AMSRD TAR R G R Gerhart 6501 E Eleven Rd MS 263 Warren MI 48397-5000 US Army

Five Years of Research Into Technology-Enhanced Learning at the Faculty of Materials Science and Technology

NASA Astrophysics Data System (ADS)

Svetský, Štefan; Moravčík, Oliver; Rusková, Dagmar; Balog, Karol; Sakál, Peter; Tanuška, Pavol

2011-01-01

The article describes a five-year period of Technology Enhanced Learning (TEL) implementation at the Faculty of Materials Science and Technology (MTF) in Trnava. It is a part of the challenges put forward by the 7th Framework Programme (ICT research in FP7) focused on "how information and communication technologies can be used to support learning and teaching". The empirical research during the years 2006-2008 was focused on technology-driven support of teaching, i. e. the development of VLE (Virtual Learning Environment) and the development of database applications such as instruments developed simultaneously with the information support of the project, and tested and applied directly in the teaching of bachelor students. During this period, the MTF also participated in the administration of the FP7 KEPLER project proposal in the international consortium of 20 participants. In the following period of 2009-2010, the concept of educational activities automation systematically began to develop. Within this concept, the idea originated to develop a universal multi-purpose system BIKE based on the batch processing knowledge paradigm. This allowed to focus more on educational approach, i.e. TEL educational-driven and to finish the programming of the Internet application - network for feedback (communication between teachers and students). Thanks to this specialization, the results of applications in the teaching at MTF could gradually be presented at the international conferences focused on computer-enhanced engineering education. TEL was implemented at a detached workplace and four institutes involving more than 600 students-bachelors and teachers of technical subjects. Four study programmes were supported, including technical English language. Altogether, the results have been presented via 16 articles in five countries, including the EU level (IGIP-SEFI).

Genome sequencing and annotation of Serratia sp. strain TEL.

PubMed

Lephoto, Tiisetso E; Gray, Vincent M

2015-12-01

We present the annotation of the draft genome sequence of Serratia sp. strain TEL (GenBank accession number KP711410). This organism was isolated from entomopathogenic nematode Oscheius sp. strain TEL (GenBank accession number KM492926) collected from grassland soil and has a genome size of 5,000,541 bp and 542 subsystems. The genome sequence can be accessed at DDBJ/EMBL/GenBank under the accession number LDEG00000000.

Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally

PubMed Central

Hofmann, Jerry; Kang, Michelle; Selzer, Rebecca; Green, Roland; Zhou, Mi; Zhong, Sheng; Zhang, Luoping; Smith, Martyn T.; Marsit, Carmen; Loh, Mignon; Buffler, Patricia; Yeh, Ru-Fang

2008-01-01

TEL-AML1 (ETV6-RUNX1) is the most common translocation in the childhood leukemias, and is a prenatal mutation in most children. This translocation has been detected at a high rate among newborns (∼1%); therefore the rate-limiting event for leukemia appears to be secondary mutations. A frequent such mutation in this subtype is partial deletion of chromosome 12p, trans from the translocation. Nine del(12p) breakpoints within six leukemia cases were sequenced to explore the etiology of this genetic event, and most involved cryptic sterile translocations. Twelve of 18 del(12p) parent sequences involved in these breakpoints were located in repeat regions (8 of these in Long Interspersed Nuclear Elements, or LINEs). This stands in contrast to TEL-AML1, in which only 21 of 110 previously assessed breakpoints (19%) occur in DNA repeats (P = 0.0001). An exploratory assessment of archived neonatal blood cards (ANB cards) revealed significantly more LINE CpG methylation in individuals at birth who were later diagnosed with TEL-AML1 leukemia, compared to individuals who did not contract leukemia (P = 0.01). Nontemplate nucleotides were also more frequent in del(12p) than in TEL-AML1 junctions (P = 0.004) suggesting formation by terminal deoxynucleotidyl transferase. Assessment of six ANB cards indicated that no del(12p) rearrangements backtracked to birth, although two of these patients were previously positive for TEL-AML1 using the same assay with comparable sensitivity. These data are compatible with the a two-stage natural history: TEL-AML1 occurs prenatally, and del(12p) occurs postnatally in more mature cells with a structure that suggests the involvement of retrotransposon instability. PMID:19047175

Government Venture Capital: A Case Study of the In-Q-Tel Model

DTIC Science & Technology

2004-03-23

their IP during the contracting process. “The folklore is that the government has a reputation for ‘ poaching ’ technology, either by getting a hook into...the introductions to individuals that can make a significant impact to a company’s business. Often these include members of government, industry...result of an In-Q-Tel-sponsored conference. Company 2 said that In-Q-Tel has made a significant impact by providing high-level introductions at

Absolute parameters of eclipsing binaries in Southern Hemisphere sky - II: QY Tel

NASA Astrophysics Data System (ADS)

Erdem, A.; Sürgit, D.; Engelbrecht, C. A.; van Heerden, H. P.; Manick, R.

2016-11-01

This paper presents the first analysis of spectroscopic and photometric observations of the neglected southern eclipsing binary star, QY Tel. Spectroscopic observations were carried out at the South African Astronomical Observatory in 2013. New radial velocity curves from this study and V light curves from the All Sky Automated Survey were solved simultaneously using modern light and radial velocity curve synthesis methods. The final model describes QY Tel as a detached binary star where both component stars fill at least half of their Roche limiting lobes. The masses and radii were found to be 1.32 (± 0.06) M⊙, 1.74 (± 0.15) R⊙ and 1.44 (± 0.09) M⊙, 2.70 (± 0.16) R⊙ for the primary and secondary components of the system, respectively. The distance to QY Tel was calculated as 365 (± 40) pc, taking into account interstellar extinction. The evolution case of QY Tel is also examined. Both components of the system are evolved main-sequence stars with an age of approximately 3.2 Gy, when compared to Geneva theoretical evolution models.

Fahr's Syndrome

MedlinePlus

... 55 Kenosia Avenue Danbury CT Danbury, CT 06810 orphan@rarediseases.org http://rarediseases.org Tel: 203-744- ... 55 Kenosia Avenue Danbury CT Danbury, CT 06810 orphan@rarediseases.org http://rarediseases.org Tel: 203-744- ...

Macular telangiectasia type 2 (MacTel) in a 34-year-old patient.

PubMed

Nicolai, Heleen; Wirix, Mieke; Spielberg, Leigh; Leys, Anita

2014-09-23

We report macular telangiectasia type 2 (MacTel) in a 34-year-old man, the youngest patient so far published with MacTel type 2. The patient presented with metamorphopsia and impaired reading ability. Diagnosis was based on bilateral abnormal macular autofluorescence, perifoveal telangiectasia with fluorescein angiographic hyperfluorescence without cystoid oedema, a small foveal avascular zone, asymmetric configuration of the foveal pit, disruptions in the inner segment/outer segment layer and hyper-reflective haze and spots in the outer nuclear layer. Although MacTel usually manifests with a slowly progressive decrease in visual acuity in the fifth to seventh decades of life, younger patients may occasionally be diagnosed with the disease. Awareness of subtle signs of the condition is essential for early diagnosis. 2014 BMJ Publishing Group Ltd.

Macular telangiectasia type 2 (MacTel) in a 34-year-old patient

PubMed Central

Nicolai, Heleen; Wirix, Mieke; Spielberg, Leigh; Leys, Anita

2014-01-01

We report macular telangiectasia type 2 (MacTel) in a 34-year-old man, the youngest patient so far published with MacTel type 2. The patient presented with metamorphopsia and impaired reading ability. Diagnosis was based on bilateral abnormal macular autofluorescence, perifoveal telangiectasia with fluorescein angiographic hyperfluorescence without cystoid oedema, a small foveal avascular zone, asymmetric configuration of the foveal pit, disruptions in the inner segment/outer segment layer and hyper-reflective haze and spots in the outer nuclear layer. Although MacTel usually manifests with a slowly progressive decrease in visual acuity in the fifth to seventh decades of life, younger patients may occasionally be diagnosed with the disease. Awareness of subtle signs of the condition is essential for early diagnosis. PMID:25249218

Radiation measurement platform for balloon flights based on the TriTel silicon detector telescope

NASA Astrophysics Data System (ADS)

Zabori, Balazs; Hirn, Attila; Pazmandi, Tamas; Apathy, Istvan; Szanto, Peter; Deme, Sandor

Several measurements have been performed on the cosmic radiation field from the surface of the Earth up to the maximum altitudes of research airplanes. However the cosmic radiation field is not well known between 15 km and 30 km. Our experiment idea based on to study the radiation environment in the stratosphere. The main technical goals of our experiment were to test at first time the TriTel 3D silicon detector telescope system for future ISS missons and to develop a balloon technology platform for advanced cosmic radiation and dosimetric measurements. The main scientific goals were to give an assessment of the cosmic radiation field at the altitude of the BEXUS balloons, to use the TriTel system to determine dosimetric and radiation quantities during the ballon flight and to intercompare the TriTel and Pille results to provide a correction factor definition method for the Pille ISS measurements. To fulfil the scientific and technological objectives several different dosimeter systems were included in the experiment: an advanced version of the TriTel silicon detector telescope, Geiger-Müller counters, Pille passive thermoluminescent dosimeters and Solid State Nuclear Track Detectors. The experiment was built by students from Hungarian universities and flew on board the BEXUS stratospheric balloon in Northern Sweden (from ESRANGE Space Center). The float altitude was approximately 28.6 km and the total flight time was about 4 hours. The active instruments measured in real time and the ground team received the collected data continuously during the mission. The main technical goals were received since the operation of the TriTel experienced no failures and the experiment worked as it expected. This paper presents the scientific goals and results. From the TriTel measurements the deposited energy spectra, the Linear Energy Transfer spectra, the average quality factor of the cosmic radiation as well as the absorbed dose and the dose equivalent were determined for the three axis. TriTel data evaluation and error estimations were studied in details. The evaluated deposited energy spectra measured with the improved TriTel instrument were compared with the count rates measured with the GM counters to calibrate them for dose rate in the cosmic radiation field at the altitude of the stratospheric balloons. From the SSNTD results the contribution of thermal neutrons was determined. In the frame of the TriTel and Pille intercomparison a correction factor calculation method was determined for future ISS data evaluation. The results will be used in the future scientific data evaluation in case of the ISS measurements. As a future outlook a short overview will be given about planned rocket radiation experiments.

Neuroleptic Malignant Syndrome

MedlinePlus

... 55 Kenosia Avenue Danbury CT Danbury, CT 06810 orphan@rarediseases.org http://rarediseases.org Tel: 203-744- ... 55 Kenosia Avenue Danbury CT Danbury, CT 06810 orphan@rarediseases.org http://rarediseases.org Tel: 203-744- ...

77 FR 71777 - Trade Mission to Egypt and Kuwait

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-04

... been determined that additional time is needed to allow for additional recruitment and marketing in... States of America, Email: [email protected] , Tel: Washington, DC, Tel: (202) 482-8178, Email: 2...

The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization.

PubMed

Sawicka, Marta; Wanrooij, Paulina H; Darbari, Vidya C; Tannous, Elias; Hailemariam, Sarem; Bose, Daniel; Makarova, Alena V; Burgers, Peter M; Zhang, Xiaodong

2016-06-24

The phosphatidylinositol 3-kinase-related protein kinases are key regulators controlling a wide range of cellular events. The yeast Tel1 and Mec1·Ddc2 complex (ATM and ATR-ATRIP in humans) play pivotal roles in DNA replication, DNA damage signaling, and repair. Here, we present the first structural insight for dimers of Mec1·Ddc2 and Tel1 using single-particle electron microscopy. Both kinases reveal a head to head dimer with one major dimeric interface through the N-terminal HEAT (named after Huntingtin, elongation factor 3, protein phosphatase 2A, and yeast kinase TOR1) repeat. Their dimeric interface is significantly distinct from the interface of mTOR complex 1 dimer, which oligomerizes through two spatially separate interfaces. We also observe different structural organizations of kinase domains of Mec1 and Tel1. The kinase domains in the Mec1·Ddc2 dimer are located in close proximity to each other. However, in the Tel1 dimer they are fully separated, providing potential access of substrates to this kinase, even in its dimeric form. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Reanalysis Of The PZ Tel System: Arguments For The Reality Of PZ Tel B To Be PZ Tel b

NASA Astrophysics Data System (ADS)

Jenkins, James

2011-09-01

I will present some new analysis of the PZ Tel system, which has recently been shown to host a young companion with a mass of around 30 Jupiter-masses, along with a debris disk of around 0.3 Lunar-masses. We have reanalyzed the iron abundance of the host star using our new spectral synthesis method, and contrary to previous results, we find the star to be super metal-rich, with a metallicity ([Fe/H]) of 0.2 dex. We also find the age of the system from chromospheric activities and pre-main sequence evolutionary models to be around 25Myrs. I will show some comparisons between the companion's bulk properties, such as broadband colours, and some of the latest evolutionary models as a function of metallicity. Finally, I will use these results to show how the companion to PZ Tel could be the first directly imaged extreme-Jovian extrasolar planet and not a low-mass brown dwarf. I acknowledge funding by Fondecyt through grant 3110004 and partial support from Centro de Astrofisica FONDAP 15010003, the GEMINI-CONICYT FUND and from the Comite Mixto ESO-GOBIERNO DE CHILE.

Equatorial Scintillation Predictions from C/NOFS Planar Langmuir Probe Electron Density Fluctuation Data

DTIC Science & Technology

2014-09-05

Brasil Tel: 55 21 3527 1682; Fax: 55 21 3527 1154 E-mail: epoc@cetuc.puc-rio.br FINAL PERFORMANCE REPORT Equatorial scintillation...Costa Centro de Estudos em Telecomunicações/CETUC Rua Marquês de São Vicente, 225 – Gávea 22451-900 Rio de Janeiro - RJ – Brasil Tel: 55 21 3527...Emanoel Costa Centro de Estudos em Telecomunicações/CETUC Rua Marquês de São Vicente, 225 – Gávea 22451-900 Rio de Janeiro - RJ – Brasil Tel: 55

Acceptance of technology-enhanced learning for a theoretical radiological science course: a randomized controlled trial.

PubMed

Nkenke, Emeka; Vairaktaris, Elefterios; Bauersachs, Anne; Eitner, Stephan; Budach, Alexander; Knipfer, Christoph; Stelzle, Florian

2012-03-30

Technology-enhanced learning (TEL) gives a view to improved education. However, there is a need to clarify how TEL can be used effectively. The study compared students' attitudes and opinions towards a traditional face-to-face course on theoretical radiological science and a TEL course where students could combine face-to-face lectures and e-learning modules at their best convenience. 42 third-year dental students were randomly assigned to the traditional face-to-face group and the TEL group. Both groups completed questionnaires before the beginning and after completion of the course on attitudes and opinions towards a traditional face-to-face lectures and technology-enhanced learning. After completion of the course both groups also filled in the validated German-language TRIL (Trierer Inventar zur Lehrevaluation) questionnaire for the evaluation of courses given at universities. Both groups had a positive attitude towards e-learning that did not change over time. The TEL group attended significantly less face-to-face lectures than the traditional group. However, both groups stated that face-to-face lectures were the basis for education in a theoretical radiological science course. The members of the TEL group rated e-mail reminders significantly more important when they filled in the questionnaire on attitudes and opinions towards a traditional face-to-face lectures and technology-enhanced learning for the second time after completion of the course. The members of the technology-enhanced learning group were significantly less confident in passing the exam compared to the members of the traditional group. However, examination results did not differ significantly for traditional and the TEL group. It seems that technology-enhanced learning in a theoretical radiological science course has the potential to reduce the need for face-to-face lectures. At the same time examination results are not impaired. However, technology-enhanced learning cannot completely replace traditional face-to-face lectures, because students indicate that they consider traditional teaching as the basis of their education.

Structure of the intact ATM/Tel1 kinase

NASA Astrophysics Data System (ADS)

Wang, Xuejuan; Chu, Huanyu; Lv, Mengjuan; Zhang, Zhihui; Qiu, Shuwan; Liu, Haiyan; Shen, Xuetong; Wang, Weiwu; Cai, Gang

2016-05-01

The ataxia-telangiectasia mutated (ATM) protein is an apical kinase that orchestrates the multifaceted DNA-damage response. Normally, ATM kinase is in an inactive, homodimer form and is transformed into monomers upon activation. Besides a conserved kinase domain at the C terminus, ATM contains three other structural modules, referred to as FAT, FATC and N-terminal helical solenoid. Here we report the first cryo-EM structure of ATM kinase, which is an intact homodimeric ATM/Tel1 from Schizosaccharomyces pombe. We show that two monomers directly contact head-to-head through the FAT and kinase domains. The tandem N-terminal helical solenoid tightly packs against the FAT and kinase domains. The structure suggests that ATM/Tel1 dimer interface and the consecutive HEAT repeats inhibit the binding of kinase substrates and regulators by steric hindrance. Our study provides a structural framework for understanding the mechanisms of ATM/Tel1 regulation as well as the development of new therapeutic agents.

Measurements of a Newly Designed BPM for the Tevatron Electron Lens 2

NASA Astrophysics Data System (ADS)

Scarpine, V. E.; Kamerdzhiev, V.; Fellenz, B.; Olson, M.; Kuznetsov, G.; Kamerdzhiev, V.; Shiltsev, V. D.; Zhang, X. L.

2006-11-01

Fermilab has developed a second electron lens (TEL-2) for beam-beam compensation in the Tevatron as part of its Run II upgrade program. Operation of the beam position monitors (BPMs) in the first electron lens (TEL-1) showed a systematic transverse position difference between short proton bunches (2 ns sigma) and long electron pulses (˜1 us) of up to ˜1.5 mm. This difference was attributed to frequency dependence in the BPM system. The TEL-2 BPMs utilize a new, compact four-plate design with grounding strips between plates to minimize crosstalk. In-situ measurements of these new BPMs are made using a stretched wire pulsed with both proton and electron beam formats. In addition, longitudinal impedance measurements of the TEL-2 are presented. Signal processing algorithm studies indicate that the frequency-dependent transverse position offset may be reduced to ˜0.1 mm for the beam structures of interest.

How comprehensive are research studies investigating the efficacy of technology-enhanced learning resources in anatomy education? A systematic review.

PubMed

Clunie, Lauren; Morris, Neil P; Joynes, Viktoria C T; Pickering, James D

2018-05-06

Anatomy education is at the forefront of integrating innovative technologies into its curricula. However, despite this rise in technology numerous authors have commented on the shortfall in efficacy studies to assess the impact such technology-enhanced learning (TEL) resources have on learning. To assess the range of evaluation approaches to TEL across anatomy education, a systematic review was conducted using MEDLINE, the Educational Resources Information Centre (ERIC), Scopus, and Google Scholar, with a total of 3,345 articles retrieved. Following the PRISMA method for reporting items, 153 articles were identified and reviewed against a published framework-the technology-enhanced learning evaluation model (TELEM). The model allowed published reports to be categorized according to evaluations at the level of (1) learner satisfaction, (2) learning gain, (3) learner impact, and (4) institutional impact. The results of this systematic review reveal that most evaluation studies into TEL within anatomy curricula were based on learner satisfaction, followed by module or course learning outcomes. Randomized controlled studies assessing learning gain with a specific TEL resource were in a minority, with no studies reporting a comprehensive assessment on the overall impact of introducing a specific TEL resource (e.g., return on investment). This systematic review has provided clear evidence that anatomy education is engaged in evaluating the impact of TEL resources on student education, although it remains at a level that fails to provide comprehensive causative evidence. Anat Sci Educ 11: 303-319. © 2017 American Association of Anatomists. © 2017 American Association of Anatomists.

Absolute parameters of detached binaries in the southern sky - III: HO Tel

NASA Astrophysics Data System (ADS)

Sürgit, D.; Erdem, A.; Engelbrecht, C. A.; van Heerden, H. P.; Manick, R.

2017-07-01

We present the first radial velocity analysis of the southern eclipsing binary star HO Tel, based on spectra obtained at the South African Astronomical Observatory in 2013. The orbital solution of this neglected binary gave the quite large spectroscopic mass ratio of 0.921(±0.005). The V light curve from the All Sky Automated Survey (ASAS) and Walraven five-colour (WULBV) photometric light curves (Spoelstra and Van Houten 1972) were solved simultaneously using the Wilson-Devinney code supplemented by the Monte Carlo search method. The final photometric model describes HO Tel as a detached binary star where both component stars fill about three-quarters of their Roche limiting lobes. The masses and radii were found to be 1.88(±0.04) M⊙, 2.28(±0.15) R⊙ and 1.73(±0.04) M⊙, 2.08(±0.16) R⊙ for the primary and secondary components of the system, respectively. The distance to HO Tel was calculated as 282(±30) pc, taking into account interstellar extinction. The evolution case of HO Tel was also examined. Both components of the system are evolved main-sequence stars with an age of approximately 1.1 Gy, when compared to Geneva theoretical evolution models.

Cyber Infrastructure Protection

DTIC Science & Technology

2011-05-01

274 TOWARD A SOLUTION THAT WORKS Building on our long history of involvement in assuring all types of communications networks, Tel- cordia has...wireless, and security areas. He currently has responsibility for a new Tel- cordia software product in IP network management, and has led all product

Physics, ballistics, and psychology: a history of the chronoscope in/as context, 1845-1890.

PubMed

Schmidgen, Henning

2005-02-01

In Wilhelm Wundt's (1832-1920) Leipzig laboratory and at numerous other research sites, the chronoscope was used to conduct reaction time experiments. The author argues that the history of the chronoscope is the history not of an instrument but of an experimental setup. This setup was initially devised by the English physicist and instrument maker Charles Wheatstone (1802-1875) in the early 1840s. Shortly thereafter, it was improved by the German clockmaker and mechanic Matthäus Hipp (1813-1893). In the 1850s, the chronoscope was introduced to ballistic research. In the early 1860s, Neuchâtel astronomer Adolphe Hirsch (1830-1901) applied it to the problem of physiological time. The extensions and variations of chronoscope use within the contexts of ballistics, physiology, and psychology presented special challenges. These challenges were met with specific attempts to reduce the errors in chronoscopic experiments on shooting stands and in the psychological laboratory.

75 FR 34630 - Iranian Transactions Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

..., Assistant Director for Licensing, tel.: 202/622-2480, Assistant Director for Policy, tel.: 202/622-4855... actively supporting terrorism as an instrument of state policy, the President prohibited the importation of...) (``IEEPA''), the President declared a national emergency with respect to the actions and policies of the...

Technology-Enhanced Learning in Science (TELS)

NASA Astrophysics Data System (ADS)

Linn, Marcia

2006-12-01

The overall research question addressed by the NSF-funded echnologyEnhanced Learning in Science (TELS) Center is whether interactive scientific visualizations embedded in high quality instructional units can be used to increase pre-college student learning in science. The research draws on the knowledge integration framework to guide the design of instructional modules, professional development activities, and assessment activities. This talk reports on results from the first year where 50 teachers taught one of the 12 TELS modules in over 200 classes in 16 diverse schools. Assessments scored with the knowledge integration rubric showed that students made progress in learning complex physics topics such as electricity, mechanics, and thermodynamics. Teachers encountered primarily technological obstacles that the research team was able to address prior to implementation. Powerful scientific visualizations required extensive instructional supports to communicate to students. Currently, TELS is refining the modules, professional development, and assessments based on evidence from the first year. Preliminary design principles intended to help research teams build on the findings will be presented for audience feedback and discussion.

Measurements of a Newly Designed BPM for the Tevatron Electron Lens 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scarpine, V. E.; Kamerdzhiev, V.; Fellenz, B.

2006-11-20

Fermilab has developed a second electron lens (TEL-2) for beam-beam compensation in the Tevatron as part of its Run II upgrade program. Operation of the beam position monitors (BPMs) in the first electron lens (TEL-1) showed a systematic transverse position difference between short proton bunches (2 ns sigma) and long electron pulses ({approx}1 us) of up to {approx}1.5 mm. This difference was attributed to frequency dependence in the BPM system. The TEL-2 BPMs utilize a new, compact four-plate design with grounding strips between plates to minimize crosstalk. In-situ measurements of these new BPMs are made using a stretched wire pulsedmore » with both proton and electron beam formats. In addition, longitudinal impedance measurements of the TEL-2 are presented. Signal processing algorithm studies indicate that the frequency-dependent transverse position offset may be reduced to {approx}0.1 mm for the beam structures of interest.« less

IUE short-wavelength high-dispersion line list for the symbiotic nova RR Telescopii

NASA Technical Reports Server (NTRS)

Aufdenberg, Jason P.

1993-01-01

An 820 minute and other long-exposure archival SWP IUE high-dispersion spectra of symbiotic star RR Tel have been combined to form a composite spectrum. In most of these spectra many lines are saturated, but weaker features appear above the continuum. Their wavelengths were measured from the composite spectrum and compared with the line list from a thorough study of RR Tel by Penston et al. (1983). Among the revised line list are 22 new line identifications from ions C III, O I, N I, Mg VI, Si I, S I, S IV, Fe II, and Ni II. N I exists inside RR Tel's H II region and is pumped by the hot component's continuum. The fluxes for all the lines in each of the spectra are presented. All of the observed ions show a secular flux decrease between 1978 and 1988. A list of SWP high-dispersion camera artifacts is also presented. The list was generated by comparing RR Tel spectra to a long-exposure sky flat.

Multifunctional Role of ATM/Tel1 Kinase in Genome Stability: From the DNA Damage Response to Telomere Maintenance

PubMed Central

2014-01-01

The mammalian protein kinase ataxia telangiectasia mutated (ATM) is a key regulator of the DNA double-strand-break response and belongs to the evolutionary conserved phosphatidylinositol-3-kinase-related protein kinases. ATM deficiency causes ataxia telangiectasia (AT), a genetic disorder that is characterized by premature aging, cerebellar neuropathy, immunodeficiency, and predisposition to cancer. AT cells show defects in the DNA damage-response pathway, cell-cycle control, and telomere maintenance and length regulation. Likewise, in Saccharomyces cerevisiae, haploid strains defective in the TEL1 gene, the ATM ortholog, show chromosomal aberrations and short telomeres. In this review, we outline the complex role of ATM/Tel1 in maintaining genomic stability through its control of numerous aspects of cellular survival. In particular, we describe how ATM/Tel1 participates in the signal transduction pathways elicited by DNA damage and in telomere homeostasis and its importance as a barrier to cancer development. PMID:25247188

Retinal Crystals in Type 2 Idiopathic Macular Telangiectasia

PubMed Central

Sallo, Ferenc B; Leung, Irene; Chung, Mina; Wolf-Schnurrbusch, Ute EK; Dubra, Alfredo; Williams, David R; Clemons, Traci; Pauleikhoff, Daniel; Bird, Alan C; Peto, Tunde

2012-01-01

Purpose To characterize the phenotype and investigate the associations of intraretinal crystalline deposits in a large cohort of Type 2 Idiopathic Macular Telangiectasia (MacTel) Design Case-control study Participants Patients with and without retinal crystals from the Macular Telangiectasia Project, an international multi-centre prospective study of Type 2 MacTel. Methods Grading of stereoscopic 30° colour fundus (CF), confocal blue light reflectance (CBR), red-free (RF) and infrared (IR) images was performed according to the MacTel Natural History Study protocol and staged using the classification system devised by Gass & Blodi. SD-OCT and adaptive optics imaging were used for a finer analysis of the phenotype. Associations between crystals and other characteristics of the disease as well as potential risk factors were investigated. Main outcome measures Presence of crystals, fundus signs of MacTel, clinical characteristics, presence of potential risk factors of MacTel. Results Out of 443 probands enrolled in the MacTel study, 203 (46%) had crystalline deposits present; 60% of the cases were bilateral at baseline. Eyes with crystals had a mean letter score of 70.7 (SD=15.9) while those without crystals had a mean of 66.5 letters (SD=15.5, p<0.001). Crystals were present at all stages of the disease and showed high reflectivity within a wide wavelength range. They were located at the anterior surface of the nerve fibre layer, arranged along the nerve fibres, within an annular area centred on the fovea. Significant associations of crystalline deposits were found with a loss of retinal transparency, MPOD loss, fluorescein leakage, retinal thickness and a break in the IS/OS junction line. Associations with environmental risk factors were not found. Conclusions Intraretinal crystals are a frequent phenomenon associated with type 2 MacTel, they may appear at all stages and may aid in the early diagnosis of the disease. Their morphology further implicates Müller cells in the pathogenesis of the disease. Insight into their physical and chemical properties may provide clues to the metabolic pathways involved in the pathogenesis of the disease. PMID:21839520

Acceptance of technology-enhanced learning for a theoretical radiological science course: a randomized controlled trial

PubMed Central

2012-01-01

Background Technology-enhanced learning (TEL) gives a view to improved education. However, there is a need to clarify how TEL can be used effectively. The study compared students' attitudes and opinions towards a traditional face-to-face course on theoretical radiological science and a TEL course where students could combine face-to-face lectures and e-learning modules at their best convenience. Methods 42 third-year dental students were randomly assigned to the traditional face-to-face group and the TEL group. Both groups completed questionnaires before the beginning and after completion of the course on attitudes and opinions towards a traditional face-to-face lectures and technology-enhanced learning. After completion of the course both groups also filled in the validated German-language TRIL (Trierer Inventar zur Lehrevaluation) questionnaire for the evaluation of courses given at universities. Results Both groups had a positive attitude towards e-learning that did not change over time. The TEL group attended significantly less face-to-face lectures than the traditional group. However, both groups stated that face-to-face lectures were the basis for education in a theoretical radiological science course. The members of the TEL group rated e-mail reminders significantly more important when they filled in the questionnaire on attitudes and opinions towards a traditional face-to-face lectures and technology-enhanced learning for the second time after completion of the course. The members of the technology-enhanced learning group were significantly less confident in passing the exam compared to the members of the traditional group. However, examination results did not differ significantly for traditional and the TEL group. Conclusions It seems that technology-enhanced learning in a theoretical radiological science course has the potential to reduce the need for face-to-face lectures. At the same time examination results are not impaired. However, technology-enhanced learning cannot completely replace traditional face-to-face lectures, because students indicate that they consider traditional teaching as the basis of their education. PMID:22463757

Crew of Hubble Space Telescope servicing mission visits Europe

NASA Astrophysics Data System (ADS)

1994-01-01

The Hubble Space telescope servicing mission in December (STS-61) was a great success and the fully refurbished orbiting telescope produced absolutely remarkable first results just two weeks ago. The 7-member crew who carried out the mission will soon be in Europe to share their experience with the Press, ESA space specialists and the European space community. Public conferences will also be held in Switzerland, the home country of ESA astronaut Claude Nicollier. The visit of the STS-61 crew is scheduled as follows: Friday 11 February, 1994 - ESA Paris, France Presentation and Press Conference Location: ESA, 8/10 Rue Mario Nikis, 75015 Paris time: 16:00 hrs - 17:30 hrs contact: ESA, Public Relations Office Tel. (+33) 1 42 73 71 55 Fax. (+33) 1 42 73 76 90 Monday 14 February, 1994 - British Aerospace, Bristol, United Kingdom Presentation and Press Conference Location: British Aerospace, FPC 333, Filton, Bristol BS12 7QW time: 10:00 hrs - 12:00 hrs contact: BAe, Public Relations Tel. (+44) 272 36 33 69 Tel. (+44) 272 36 33 68 Tuesday 15 February, 1994 - ESA/ESTEC, Noordwijk, the Netherlands Presentation and Press Conference Location: Noordwijk Space Expo, Keplerlaan 3, 2201 AZ Noordwijk, the Netherlands time: 09:30 hrs - 12:00 hrs contact: ESTEC Public Relations Office Tel. (+31) 1719 8 3006 Fax. (+31) 1719 17 400 Wednesday 16 February, 1944 - ESO, Garching - Munich, Germany Presentation and Press Conference Location: European Southern Observatory, Karl- Schwarzschild-Str. 2, 85748 Garching -Munich, Germany time: to be decided contact: ESO Information Service Tel. (+49) 89 32 006 276 Fax. (+49) 89 320 23 62 Thursday 17 February, 1994 - Bern, Switzerland a. Presentation and Press Conference Location: Hotel Bern, Zeughausgasse 9, 3001 Bern, Switzerland time: 09:30 hrs contact: Press & Information Service of the Federal Dept. for Education & Sciences Tel. (+41) 31 322 80 34 Fax. (+41) 31 312 30 15 b. Public conference Location: University of Bern, Institute of Physics time: 18:00 hrs - 20:00 hrs Friday 18 February, 1994 - Geneva, Switzerland a. Presentation and Press Conference Location: Geneva Observatory, Chemin des Maillettes 51, 1290 Sauverny, Switzerland time: 10:00 hrs - 11:30 hrs contact: Press Service University of Geneva Tel. (+41) 22 705 77 17 Tel. (+41) 22 328 25 66 b. Public Conference Location: University of Geneva, Auditorium Piaget, Uni Dufour time: 18:00 hrs - 20:30 hrs For accreditation and further information on these events, please get in touch directly with the contact listed for each location.

RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithromycin susceptibility

PubMed Central

Shoji, Tatsuma; Takaya, Akiko; Sato, Yoshiharu; Kimura, Satoshi; Suzuki, Tsutomu; Yamamoto, Tomoko

2015-01-01

Adenine at position 752 in a loop of helix 35 from positions 745 to 752 in domain II of 23S rRNA is involved in binding to the ribosome of telithromycin (TEL), a member of ketolides. Methylation of guanine at position 748 by the intrinsic methyltransferase RlmAII enhances binding of telithromycin (TEL) to A752 in Streptococcus pneumoniae. We have found that another intrinsic methylation of the adjacent uridine at position 747 enhances G748 methylation by RlmAII, rendering TEL susceptibility. U747 and another nucleotide, U1939, were methylated by the dual-specific methyltransferase RlmCD encoded by SP_1029 in S. pneumoniae. Inactivation of RlmCD reduced N1-methylated level of G748 by RlmAII in vivo, leading to TEL resistance when the nucleotide A2058, located in domain V of 23S rRNA, was dimethylated by the dimethyltransferase Erm(B). In vitro methylation of rRNA showed that RlmAII activity was significantly enhanced by RlmCD-mediated pre-methylation of 23S rRNA. These results suggest that RlmCD-mediated U747 methylation promotes efficient G748 methylation by RlmAII, thereby facilitating TEL binding to the ribosome. PMID:26365244

Ontology Extraction Tools: An Empirical Study with Educators

ERIC Educational Resources Information Center

Hatala, M.; Gasevic, D.; Siadaty, M.; Jovanovic, J.; Torniai, C.

2012-01-01

Recent research in Technology-Enhanced Learning (TEL) demonstrated several important benefits that semantic technologies can bring to the TEL domain. An underlying assumption for most of these research efforts is the existence of a domain ontology. The second unspoken assumption follows that educators will build domain ontologies for their…

Moving Technology-Enhanced-Learning Forward: Bridging Divides through Leadership

ERIC Educational Resources Information Center

Bälter, Olle

2017-01-01

A study of academics and professional staff engaged in the emerging field of Technology Enhanced Learning (TEL) reveal three areas of significant difference in reference to perspectives about TEL. These differences rest on the following individual characteristics: 1) research areas and competencies, 2) academic level, and 3) attitudes towards…

Teaching Gender in Israel: Experiences at the Tel Aviv University

ERIC Educational Resources Information Center

Fenster, Tovi

2011-01-01

This paper examines the ways in which neoliberal economic policies are affecting academic work in Israeli universities, prioritizing programs that can generate their own funding, External philanthropic support from North America has enabled creation of an interdisciplinary Women and Gender Studies Program at Tel Aviv University that draws…

New TEL Environments for Vocational Education--Teacher's Instructional Perspective

ERIC Educational Resources Information Center

Hämäläinen, Raija; Cattaneo, Alberto

2015-01-01

Modern vocational education is increasingly taking place in new technology-enhanced learning (TEL) settings. On the one hand, vocational education can benefit from the opportunities of technological development. On the other hand, such technologies may create new challenges for teachers. Therefore, there is a particular need to pay more attention…

Modelling Benefits-Oriented Costs for Technology Enhanced Learning

ERIC Educational Resources Information Center

Laurillard, Diana

2007-01-01

The introduction of technology enhanced learning (TEL) methods changes the deployment of the most important resource in the education system: teachers' and learners' time. New technology promises greater personalization and greater productivity, but without careful modeling of the effects on the use of staff time, TEL methods can easily increase…

Evaluating Recommender Systems for Technology Enhanced Learning: A Quantitative Survey

ERIC Educational Resources Information Center

Erdt, Mojisola; Fernandez, Alejandro; Rensing, Christoph

2015-01-01

The increasing number of publications on recommender systems for Technology Enhanced Learning (TEL) evidence a growing interest in their development and deployment. In order to support learning, recommender systems for TEL need to consider specific requirements, which differ from the requirements for recommender systems in other domains like…

The 3P Learning Model

ERIC Educational Resources Information Center

Chatti, Mohamed Amine; Jarke, Matthias; Specht, Marcus

2010-01-01

Recognizing the failures of traditional Technology Enhanced Learning (TEL) initiatives to achieve performance improvement, we need to rethink how we design new TEL models that can respond to the learning requirements of the 21st century and mirror the characteristics of knowledge and learning which are fundamentally personal, social, distributed,…

This photocopy of an engineering drawing shows the floor plan ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

This photocopy of an engineering drawing shows the floor plan of the Liner Lab, including room functions. Austin, Field & Fry, Architects Engineers, 22311 West Third Street, Los Angeles 57, California: Edwards Test Station Complex Phase II, Jet Propulsion Laboratory, California Institute of Technology, Edwards Air Force Base, Edwards, California: "Liner Laboratory, Floor Plan and Schedules," drawing no. E33/4-2, 26 June 1962. California Institute of Technology, Jet Propulsion Laboratory, Plant Engineering: engineering drawings of structures at JPL Edwards Facility. Drawings on file at JPL Plant Engineering, Pasadena, California. California Institute of Technology, Jet Propulsion Laboratory, Plant Engineering: engineering drawings of structures at JPL Edwards Facility. Drawings on file at JPL Plant Engineering, Pasadena, California - Jet Propulsion Laboratory Edwards Facility, Liner Laboratory, Edwards Air Force Base, Boron, Kern County, CA

Statistical Analysis Tools for Learning in Engineering Laboratories.

ERIC Educational Resources Information Center

Maher, Carolyn A.

1990-01-01

Described are engineering programs that have used automated data acquisition systems to implement data collection and analyze experiments. Applications include a biochemical engineering laboratory, heat transfer performance, engineering materials testing, mechanical system reliability, statistical control laboratory, thermo-fluid laboratory, and a…

Factors Affecting Academics' Involvement in TEL Continuing Professional Development (CPD)

ERIC Educational Resources Information Center

AlMutlaq, Abdullah; Dimitriadi, Yota; McCrindle, Rachel

2017-01-01

Reinforcing the level of essentiality of understanding the factors that influence the involvement in TEL-oriented CPD and the challenges to the sustained expansion of their expertise not only for academics, but also professional bodies and educational developer for effective integration of digital technologies in teaching and learning remains is…

Contextualizing Learning Scenarios According to Different Learning Management Systems

ERIC Educational Resources Information Center

Drira, R.; Laroussi, M.; Le Pallec, X.; Warin, B.

2012-01-01

In this paper, we first demonstrate that an instructional design process of Technology Enhanced Learning (TEL) systems based on a Model Driven Approach (MDA) addresses the limits of Learning Technology Standards (LTS), such as SCORM and IMS-LD. Although these standards ensure the interoperability of TEL systems across different Learning Management…

The Tennessee Lottery Scholarship Program: Impact on Retention

ERIC Educational Resources Information Center

Puryear, Carol G.

2009-01-01

This study examined if the Tennessee Education Lottery Scholarship (TELS), which began in 2004, was related to student retention at the six Tennessee Board of Regents four-year institutions. This study investigated the impact of the TELS on student retention at TBR universities and general knowledge regarding retention. Post-facto data were…

Local Tax Limits, Student Achievement, and School-Finance Equalization

ERIC Educational Resources Information Center

Davis, Matthew; Vedder, Andrea; Stone, Joe

2016-01-01

Evidence that local tax and expenditure limits (TELs) for public K-12 schools lower student achievement is widely attributed to the effects of reduced funding, but our results cast doubt on reduced funding as the primary explanation for negative effects of TELs and instead suggest the importance of the predictability of funding. Students in…

The Benefits of Testing for Learning on Later Performance

ERIC Educational Resources Information Center

McConnell, Meghan M.; St-Onge, Christina; Young, Meredith E.

2015-01-01

Testing has been shown to enhance retention of learned information beyond simple studying, a phenomena known as test-enhanced learning (TEL). Research has shown that TEL effects are greater for tests that require the production of responses [e.g., short-answer questions (SAQs)] relative to tests that require the recognition of correct answers…

75 FR 18783 - Middle East Public Health Mission; Application Deadline Extended

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-13

..., Baltimore U.S. Export Assistance Center, Tel: 410- 962-4518, Fax: 410-962-4529, E-mail: [email protected] . Ms. Lisa C. Huot, U.S. Department of Commerce, Washington, DC 20230, Tel: 202-482-2796, Fax: 202-482-0115, E-Mail: Lisa[email protected] . Sean Timmins, Global Trade Programs, Commercial Service...

Instructional Design or School Politics? A Discussion of "Orchestration" in TEL Research

ERIC Educational Resources Information Center

Perrotta, C.; Evans, M. A.

2013-01-01

This paper argues that the emphasis on orchestration as a metaphor for teaching in technology-enhanced learning (TEL) environments, featured in recent academic discussions, is an opportunity to broaden the scope of the inquiry into educational technology. Drawing on sociological literature and research that investigated the systemic factors that…

The Potential Relevance of Cognitive Neuroscience for the Development and Use of Technology-Enhanced Learning

ERIC Educational Resources Information Center

Howard-Jones, Paul; Ott, Michela; van Leeuwen, Theo; De Smedt, Bert

2015-01-01

There is increasing interest in the application of cognitive neuroscience in educational thinking and practice, and here we review findings from neuroscience that demonstrate its potential relevance to technology-enhanced learning (TEL). First, we identify some of the issues in integrating neuroscientific concepts into TEL research. We caution…

T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility

PubMed Central

Borbulevych, Oleg Y.; Piepenbrink, Kurt H.; Gloor, Brian E.; Scott, Daniel R.; Sommese, Ruth F.; Cole, David K.; Sewell, Andrew K.; Baker, Brian M.

2011-01-01

Summary Tell mediated immunity requires T cell receptor (TCR) cross-reactivity, the mechanisms behind which remain incompletely elucidated. The αβ TCR A6 recognizes both the Tax (LLFGYPVYV) and Tel1p (MLWGYLQYV) peptides presented by the human class I MHC molecule HLA-A2. Here we found that although the two ligands are ideal structural mimics, they form substantially different interfaces with A6, with conformational differences in the peptide, the TCR, and unexpectedly, the MHC molecule. The differences between the Tax and Tel1p ternary complexes could not be predicted from the free peptide-MHC structures and are inconsistent with a traditional induced-fit mechanism. Instead, the differences were attributable to peptide and MHC molecular motion present in Tel1p-HLA-A2 but absent in Tax-HLA-A2. Differential “tuning” of the dynamic properties of HLA-A2 by the Tax and Tel1p peptides thus facilitates cross-recognition and impacts how structural diversity can be presented to and accommodated by receptors of the immune system. PMID:20064447

Telomerase and Tel1p Preferentially Associate with Short Telomeres in S. cerevisiae

PubMed Central

Sabourin, Michelle; Tuzon, Creighton T.; Zakian, Virginia A.

2009-01-01

SUMMARY In diverse organisms, telomerase preferentially elongates short telomeres. We generated a single short telomere in otherwise wild-type (WT) S. cerevisiae cells. The binding of the positive regulators Ku and Cdc13p was similar at short and WT-length telomeres. The negative regulators Rif1p and Rif2p were present at the short telomere, although Rif2p levels were reduced. Two telomerase holoenzyme components, Est1p and Est2p, were preferentially enriched at short telomeres in late S/G2 phase, the time of telomerase action. Tel1p, the yeast ATM-like checkpoint kinase, was highly enriched at short telomeres from early S through G2 phase and even into the next cell cycle. Nonetheless, induction of a single short telomere did not elicit a cell-cycle arrest. Tel1p binding was dependent on Xrs2p and required for preferential binding of telomerase to short telomeres. These data suggest that Tel1p targets telomerase to the DNA ends most in need of extension. PMID:17656141

RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithromycin susceptibility.

PubMed

Shoji, Tatsuma; Takaya, Akiko; Sato, Yoshiharu; Kimura, Satoshi; Suzuki, Tsutomu; Yamamoto, Tomoko

2015-10-15

Adenine at position 752 in a loop of helix 35 from positions 745 to 752 in domain II of 23S rRNA is involved in binding to the ribosome of telithromycin (TEL), a member of ketolides. Methylation of guanine at position 748 by the intrinsic methyltransferase RlmA(II) enhances binding of telithromycin (TEL) to A752 in Streptococcus pneumoniae. We have found that another intrinsic methylation of the adjacent uridine at position 747 enhances G748 methylation by RlmA(II), rendering TEL susceptibility. U747 and another nucleotide, U1939, were methylated by the dual-specific methyltransferase RlmCD encoded by SP_1029 in S. pneumoniae. Inactivation of RlmCD reduced N1-methylated level of G748 by RlmA(II) in vivo, leading to TEL resistance when the nucleotide A2058, located in domain V of 23S rRNA, was dimethylated by the dimethyltransferase Erm(B). In vitro methylation of rRNA showed that RlmA(II) activity was significantly enhanced by RlmCD-mediated pre-methylation of 23S rRNA. These results suggest that RlmCD-mediated U747 methylation promotes efficient G748 methylation by RlmA(II), thereby facilitating TEL binding to the ribosome. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Human parvovirus B19 in childhood acute lymphoblastic leukaemia in Basrah.

PubMed

Ibrahem, Wijdan Nazar; Hasony, Hassan Jaber; Hassan, Jenan Ghulam

2014-01-01

To investigate the association of human parvovirus B19 infection with the onset of acute lymphoblastic leukaemia and its effect on TEL-AML-1 fusion gene and the presence of mutant P53. The case-control study was conducted at Basrah Hospital for Paediatrics and Gynaecology, Basrah, Iraq, from May 2009 to April 2010. A total of 100 blood samples were collected from 40 newly diagnosed cases and 60 healthy children to serve as control matched by age and gender. Human parvovirus B19-IgG and anti-P53 antibody were detected by enzyme-linked immunosorbent assay and TEL-AML-1 fusion gene was detected by reverse transcriptase-polymerase chain reaction on extracted ribonucleic acid from fresh blood samples using specified primers. SPSS 15 was used for statistical analysis. A higher proportion of human parvovirus B19-positive cases was found in leukaemic patients (n=19; 47.5%) compared to 12 (20%) in the control group (p<0.05). There was significant association between TEL-AML-1 translocation and human parvovirus-B19 infection as 10 (71.4%) of TEL-AML-1 translocation-positive cases had human parvovirus-B19 IgG. On the other hand, there was no association between such infections and P53 gene mutation in the patients. Human parvovirus-B19 infection is common in the population, with higher prevalence among leukaemic patients with significant association between human parvovirus-B19 and TEL-AML-1 fusion gene in patients of acute lymphoblastic leukaemia.

An evaluation of UK foundation trainee doctors' learning behaviours in a technology-enhanced learning environment.

PubMed

Brooks, Hannah L; Pontefract, Sarah K; Hodson, James; Blackwell, Nicholas; Hughes, Elizabeth; Marriott, John F; Coleman, Jamie J

2016-05-03

Technology-Enhanced Learning (TEL) can be used to educate Foundation Programme trainee (F1 and F2) doctors. Despite the advantages of TEL, learning behaviours may be exhibited that are not desired by system developers or educators. The aim of this evaluation was to investigate how learner behaviours (e.g. time spent on task) were affected by temporal (e.g. time of year), module (e.g. word count), and individual (e.g. knowledge) factors for 16 mandatory TEL modules related to prescribing and therapeutics. Data were extracted from the SCRIPT e-Learning platform for first year Foundation trainee (F1) doctors in the Health Education England's West Midland region from 1(st) August 2013 to 5(th) August 2014. Generalised Estimating Equation models were used to examine the relationship between time taken to complete modules, date modules were completed, pre- and post-test scores, and module factors. Over the time period examined, 688 F1 doctors interacted with the 16 compulsory modules 10,255 times. The geometric mean time taken to complete a module was 28.9 min (95% Confidence Interval: 28.4-29.5) and 1,075 (10.5%) modules were completed in less than 10 min. In February and June (prior to F1 progression reviews) peaks occurred in the number of modules completed and troughs in the time taken. Most modules were completed, and the greatest amount of time was spent on the learning on a Sunday. More time was taken by those doctors with greater pre-test scores and those with larger improvements in test scores. Foundation trainees are exhibiting unintended learning behaviours in this TEL environment, which may be attributed to several factors. These findings can help guide future developments of this TEL programme and the integration of other TEL programmes into curricula by raising awareness of potential behavioural issues that may arise.

Large geomagnetic field anomalies revealed in Bronze to Iron Age archeomagnetic data from Tel Megiddo and Tel Hazor, Israel

NASA Astrophysics Data System (ADS)

Shaar, Ron; Tauxe, Lisa; Ron, Hagai; Ebert, Yael; Zuckerman, Sharon; Finkelstein, Israel; Agnon, Amotz

2016-05-01

Geomagnetic field measurements from the past few centuries show heightened secular variation activity in the southern hemisphere associated with the south Atlantic anomaly (SAA). It is uncertain whether geomagnetic anomalies at a similar scale have existed in the past owing to limited coverage and uncertainties in the paleomagnetic database. Here we provide new evidence from archaeological sources in the Levant suggesting a large positive northern hemisphere anomaly, similar in magnitude to the SAA during the 9th-8th centuries BCE, called ;Levantine Iron Age anomaly;. We also report an additional geomagnetic spike in the 8th century. The new dataset comprises 73 high precision paleointensity estimates from ca. 3000 BCE to 732 BCE, and five directional measurements between the 14th and the 9th centuries BCE. Well-dated pottery and cooking ovens were collected from twenty archaeological strata in two large contemporaneous stratigraphical mounds (tells) in Israel: Tel Megiddo and Tel Hazor. The new data are combined with previously published data and interpreted automatically using the PmagPy Thellier GUI program. The Tel Megiddo and Tel Hazor data sets demonstrate excellent internal consistency and remarkable agreement with published data from Mesopotamia (Syria). The data illustrate the evolution of an extreme geomagnetic high that culminated in at least two spikes between the 11th and the 8th centuries BCE (Iron Age in the Levant). The paleomagnetic directional data of the 9th century BCE show positive inclination anomalies, and deviations of up to 22° from the averaged geocentric axial dipole (GAD) direction. From comparison of the Levantine archaeomagnetic data with IGRF model for 2015 we infer the ;Levantine Iron Age anomaly; between the 10th and the 8th centuries BCE is a local positive anomaly. The eastward extent of the anomaly is currently unknown.

The Gemini NICI Planet-finding Campaign: Discovery of a Close Substellar Companion to the Young Debris Disk Star PZ Tel

NASA Astrophysics Data System (ADS)

Biller, Beth A.; Liu, Michael C.; Wahhaj, Zahed; Nielsen, Eric L.; Close, Laird M.; Dupuy, Trent J.; Hayward, Thomas L.; Burrows, Adam; Chun, Mark; Ftaclas, Christ; Clarke, Fraser; Hartung, Markus; Males, Jared; Reid, I. Neill; Shkolnik, Evgenya L.; Skemer, Andrew; Tecza, Matthias; Thatte, Niranjan; Alencar, Silvia H. P.; Artymowicz, Pawel; Boss, Alan; de Gouveia Dal Pino, Elisabete; Gregorio-Hetem, Jane; Ida, Shigeru; Kuchner, Marc J.; Lin, Douglas; Toomey, Douglas

2010-09-01

We report the discovery of a tight substellar companion to the young solar analog PZ Tel, a member of the β Pic moving group observed with high-contrast adaptive optics imaging as part of the Gemini Near-Infrared Coronagraphic Imager Planet-Finding Campaign. The companion was detected at a projected separation of 16.4 ± 1.0 AU (0farcs33 ± 0farcs01) in 2009 April. Second-epoch observations in 2010 May demonstrate that the companion is physically associated and shows significant orbital motion. Monte Carlo modeling constrains the orbit of PZ Tel B to eccentricities >0.6. The near-IR colors of PZ Tel B indicate a spectral type of M7 ± 2 and thus this object will be a new benchmark companion for studies of ultracool, low-gravity photospheres. Adopting an age of 12+8 -4 Myr for the system, we estimate a mass of 36 ± 6 M Jup based on the Lyon/DUSTY evolutionary models. PZ Tel B is one of the few young substellar companions directly imaged at orbital separations similar to those of giant planets in our own solar system. Additionally, the primary star PZ Tel A shows a 70 μm emission excess, evidence for a significant quantity of circumstellar dust that has not been disrupted by the orbital motion of the companion. Based on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc., under a cooperative agreement with the NSF on behalf of the Gemini partnership: the National Science Foundation (United States), the Science and Technology Facilities Council (United Kingdom), the National Research Council (Canada), CONICYT (Chile), the Australian Research Council (Australia), Ministério da Ciência e Tecnologia (Brazil), and Ministerio de Ciencia, Tecnología e Innovación Productiva (Argentina).

Tennessee Education Lottery Scholarship Program Annual Report: Recipient Outcomes through Fall 2012

ERIC Educational Resources Information Center

Tennessee Higher Education Commission, 2013

2013-01-01

The Tennessee Education Lottery Scholarship (TELS) program was designed to meet the unique needs of the state of Tennessee while also incorporating the hallmark elements of existing merit-based aid programs in other states. Developed through a process involving elected officials and members of the academic community, the TELS program aims to…

Identifying Areas of Tension in the Field of Technology-Enhanced Learning: Results of an International Delphi Study

ERIC Educational Resources Information Center

Plesch, Christine; Kaendler, Celia; Rummel, Nikol; Wiedmann, Michael; Spada, Hans

2013-01-01

Despite steady progress in research in technology-enhanced learning (TEL), the translation of research findings and technology into educational practices falls short of expectations. We present five Areas of Tension which were identified and evaluated in an international Delphi study on TEL. These tensions might impede a more comprehensive…

Implementing a Cost Effectiveness Analyzer for Web-Supported Academic Instruction: A Campus Wide Analysis

ERIC Educational Resources Information Center

Cohen, Anat; Nachmias, Rafi

2009-01-01

This paper describes the implementation of a quantitative cost effectiveness analyzer for Web-supported academic instruction that was developed in Tel Aviv University during a long term study. The paper presents the cost effectiveness analysis of Tel Aviv University campus. Cost and benefit of 3,453 courses were analyzed, exemplifying campus-wide…

Organizing the Library to Suit the Undergraduates' Information Gathering Behavior at the Tel-Hai Academic College in Israel

ERIC Educational Resources Information Center

Chai, Iris

2007-01-01

The study examined the factors influencing information gathering behavior of undergraduates at Tel-Hai Academic College, so that library services can cope effectively with this behavior. Related to the findings, we changed our circulation desk to become a "one stop shop" for directions to all library information.

A Delphi Study on Technology Enhanced Learning (TEL) Applied on Computer Science (CS) Skills

ERIC Educational Resources Information Center

Porta, Marcela; Mas-Machuca, Marta; Martinez-Costa, Carme; Maillet, Katherine

2012-01-01

Technology Enhanced Learning (TEL) is a new pedagogical domain aiming to study the usage of information and communication technologies to support teaching and learning. The following study investigated how this domain is used to increase technical skills in Computer Science (CS). A Delphi method was applied, using three-rounds of online survey…

29 CFR 776.20 - “Goods.”

Code of Federal Regulations, 2011 CFR

2011-07-01

... ingredient thereof, but does not include goods after their delivery into the actual physical possession of... pointed out in Lenroot v. Western Union Tel. Co., 141 F. 2d 400 (C.A. 2), the legislative history shows... amendment. 19 Western Union Tel. Co. v. Lenroot 323 U.S. 490. 20 Mabee v. White Plains Pub. Co., 327 U.S...

Diffusion of Web Supported Instruction in Higher Education--The Case of Tel-Aviv University

ERIC Educational Resources Information Center

Soffer, Tal; Nachmias, Rafi; Ram, Judith

2010-01-01

This paper describes a study that focused on long-term web-supported learning diffusion among lecturers at Tel Aviv University (TAU), from an organizational point of view. The theoretical models we used to examine this process are Rogers' model for "Diffusion of Innovation" (1995) and Bass's "Diffusion Model" (1969). The study…

78 FR 48862 - Agency Information Collection Activities; Submission to the Office of Management and Budget for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-12

...; Submission to the Office of Management and Budget for Review and Approval; Comment Request; NAEP Wave 2 (TEL... issues: (1) Is this collection necessary to the proper functions of the Department; (2) will this... notice will be considered public records. Title of Collection: NAEP Wave 2 (TEL and Assessment Feedback...

Influencing Factors for Adopting Technology Enhanced Learning in the Medical Schools of Punjab, Pakistan

ERIC Educational Resources Information Center

Iqbal, Shazia; Ahmad, Shahzad; Willis, Ian

2017-01-01

As the successful establishment of technology supported educational systems requires wide investment in terms of finances and faculty time, this study explores the influencing factors in the adoption of Technology Enhanced Learning (TEL) and the main barriers encountered during the use of TEL in Punjab, Pakistan. Semi-structured interviews were…

Determination of alkyllead compounds by HPLC/ICP using a glass-frit nebulizer ICP interface

NASA Astrophysics Data System (ADS)

Ibrahim, Mona; Nisamaneepong, Wipawan; Haas, David L.; Caruso, Joseph A.

The glass-frit nebulizer, by forming a very fine mist, has improved the ability of the ICP to accept the introduction of organic solvents with high evaporation rates. The reversed-phase chromatographic separation of TML and TEL, and their determination with glass frit nebulization ICP was accomplished with various mobile phases and columns. The separation of several trialkyllead salts also was studied on a strong cation exchange column, but these compounds were not determined with the glass frit nebulizer interface. Detection limits as low as 33 pg s -1 for TML and 100 pg s -1 for TEL and precision of 3.4% for TML and 6.9% relative standard deviation for TEL were obtained.

Student research laboratory for optical engineering

NASA Astrophysics Data System (ADS)

Tolstoba, Nadezhda D.; Saitgalina, Azaliya; Abdula, Polina; Butova, Daria

2015-10-01

Student research laboratory for optical engineering is comfortable place for student's scientific and educational activity. The main ideas of laboratory, process of creation of laboratory and also activity of laboratory are described in this article. At ITMO University in 2013-2014 were formed a lot of research laboratories. SNLO is a student research (scientific) laboratory formed by the Department of Applied and computer optics of the University ITMO (Information Technologies of Mechanics and Optics). Activity of laboratory is career guidance of entrants and students in the field of optical engineering. Student research laboratory for optical engineering is a place where student can work in the interesting and entertaining scientific atmosphere.

76 FR 13438 - AccessTel, Inc., American Asset Management Corp., DME Interactive Holdings, Inc., DocuPort, Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-11

... SECURITIES AND EXCHANGE COMMISSION [File No. 500-1] AccessTel, Inc., American Asset Management Corp., DME Interactive Holdings, Inc., DocuPort, Inc., and iCarbon Corp., Order of Suspension of Trading March 8, 2011. It appears to the Securities and Exchange Commission that there is a lack of current and accurate information concerning the...

The Development of Technology Enhanced Learning: Findings from a 2008 Survey of UK Higher Education Institutions

ERIC Educational Resources Information Center

Jenkins, Martin; Browne, Tom; Walker, Richard; Hewitt, Roger

2011-01-01

This article summarises the key findings from a UK survey of higher education institutions, focusing on the development of technology enhanced learning (TEL). TEL is defined as any online facility or system that directly supports learning and teaching. The 2008 survey builds upon previous UCISA surveys conducted in 2001, 2003 and 2005 and for…

Renata Adler Memorial Research Center for Child Welfare and Protection, Tel-Aviv University

ERIC Educational Resources Information Center

Ronen, Tammie

2011-01-01

The Renata Adler Memorial Research Center for Child Welfare and Protection operates within the Bob Shapell School of Social Work at Tel-Aviv University in Israel. The main aims of this research center are to facilitate study and knowledge about the welfare of children experiencing abuse or neglect or children at risk and to link such knowledge to…

A theory of expert leadership (TEL) in psychiatry.

PubMed

Goodall, Amanda H

2016-06-01

Leaders' technical competence - 'expert knowledge' - has been shown in many settings to be associated with better organizational performance. In universities, for example, there is longitudinal evidence that research-focused scholars make the best leaders; results from a hospital study show that doctors instead of professional managers are most closely associated with the best performing institutions. To explain these patterns, and raise hypotheses, a theory of expert leadership (TEL) has been developed that might explain these patterns. In this paper the framework for expert leadership is applied to psychiatry. The TEL proposes that psychiatric leaders, as opposed to non-expert managers, improve organizational performance through several channels. First, experts' knowledge influences organizational strategy. Second, having been 'one of them', a psychiatrist understands how to create the optimal work environment for psychiatric teams, through appropriate goal-setting, evaluation and support. These factors are positively associated with workers' wellbeing and performance. Third, exceptional psychiatrist-leaders are likely to set high standards for hiring. Fourth, leaders' credibility extends their influence among core workers, and also signals organizational priorities to stakeholders. Finally, a necessary prerequisite of TEL is that expert leaders have direct executive power inclusive of budgetary and strategic oversight. © The Royal Australian and New Zealand College of Psychiatrists 2015.

Inhibition of telomerase recruitment and cancer cell death.

PubMed

Nakashima, Mai; Nandakumar, Jayakrishnan; Sullivan, Kelly D; Espinosa, Joaquín M; Cech, Thomas R

2013-11-15

Continued proliferation of human cells requires maintenance of telomere length, usually accomplished by telomerase. Telomerase is recruited to chromosome ends by interaction with a patch of amino acids (the TEL patch, for TPP1 glutamate (E) and leucine (L)-rich patch) on the surface of telomere protein TPP1. In previous studies, interruption of this interaction by mutation prevented telomere extension in HeLa cells, but the cell culture continued to grow. We now show that the telomerase inhibitor BIBR1532 acts together with TEL patch mutations to inhibit the growth of HeLa cell lines and that apoptosis is a prominent mechanism of death of these cells. Survivor cells take over the population beginning around 40 days in culture. These cells no longer express the TEL patch mutant TPP1, apparently because of silencing of the expression cassette, a survival mechanism that would not be available to cancer cells. These results provide hope that inhibiting the binding of telomerase to the TEL patch of TPP1, perhaps together with a modest inhibition of the telomerase enzyme, could comprise an effective anticancer therapy for the ∼90% of human tumors that are telomerase-positive.

Carbon dioxide (CO2) laser third eyelid excision: surgical description and report of 7 cases.

PubMed

Dees, Dustin D; Knollinger, Amy M; MacLaren, Nicole E

2015-09-01

To describe a novel technique for third eyelid (TEL) excision using a carbon dioxide (CO2) laser. Prospective. The procedure was performed on six canine patients and one feline patient. The laser was set to 6 Watts (W) of power and a linear continuous setting. Forceps were used to elevate the TEL and, with a protective shield covering the cornea, the base was cut and cauterized simultaneously. Minimal to no hemorrhage was observed, and the conjunctiva was left to heal by second intention. Seven patients underwent unilateral surgical TEL excision. All patients had suspected neoplasms affecting either the glandular tissues or conjunctival surfaces of the TEL. Clean surgical margins were achieved in all but one patient. All surgical sites were considered healed by 14 days showing mild-to-moderate conjunctival hyperemia and accumulation of mucoid discharge at the ventronasal fornix. One patient experienced postoperative keratoconjunctivitis sicca. Prolapse of orbital fat was not observed in any patient. Use of CO2 laser appears to be an efficient and effective means for surgical third eyelid removal with excellent postoperative comfort and minimal complications. © 2014 American College of Veterinary Ophthalmologists.

33 CFR 334.150 - Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory.

Code of Federal Regulations, 2012 CFR

2012-07-01

....; experimental test area, U.S. Navy Marine Engineering Laboratory. 334.150 Section 334.150 Navigation and... Marine Engineering Laboratory. (a) The restricted area. The waters of Severn River shoreward of a line beginning at the southeasternmost corner of the U.S. Navy Marine Engineering Laboratory sea wall and running...

33 CFR 334.150 - Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory.

Code of Federal Regulations, 2011 CFR

2011-07-01

....; experimental test area, U.S. Navy Marine Engineering Laboratory. 334.150 Section 334.150 Navigation and... Marine Engineering Laboratory. (a) The restricted area. The waters of Severn River shoreward of a line beginning at the southeasternmost corner of the U.S. Navy Marine Engineering Laboratory sea wall and running...

33 CFR 334.150 - Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory.

Code of Federal Regulations, 2014 CFR

2014-07-01

....; experimental test area, U.S. Navy Marine Engineering Laboratory. 334.150 Section 334.150 Navigation and... Marine Engineering Laboratory. (a) The restricted area. The waters of Severn River shoreward of a line beginning at the southeasternmost corner of the U.S. Navy Marine Engineering Laboratory sea wall and running...

33 CFR 334.150 - Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory.

Code of Federal Regulations, 2013 CFR

2013-07-01

....; experimental test area, U.S. Navy Marine Engineering Laboratory. 334.150 Section 334.150 Navigation and... Marine Engineering Laboratory. (a) The restricted area. The waters of Severn River shoreward of a line beginning at the southeasternmost corner of the U.S. Navy Marine Engineering Laboratory sea wall and running...

33 CFR 334.150 - Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory.

Code of Federal Regulations, 2010 CFR

2010-07-01

....; experimental test area, U.S. Navy Marine Engineering Laboratory. 334.150 Section 334.150 Navigation and... Marine Engineering Laboratory. (a) The restricted area. The waters of Severn River shoreward of a line beginning at the southeasternmost corner of the U.S. Navy Marine Engineering Laboratory sea wall and running...

Events diary

NASA Astrophysics Data System (ADS)

2000-01-01

From 18 January until 28 March the 2000 IEE Faraday Lecture will be touring venues in the UK, aiming to inspire and encourage students to choose a career in science and engineering. The lecture tour is being supported by communications and IT company, Marconi, and it is being presented by University College London. Interactive experiments for the audience of 14 - 16 year-olds will combine with a multimedia presentation on the theme `Time and Place in the Communications Age', exploring our ability to make precise measurements of time, place and space and how these impact on our personal and business lives. Among the curious facts from the lecture is the discovery that Cornwall rises and falls by 20 cm every time the tide moves in and out. The whole of the UK rises and falls by 50 cm every time the Moon goes by and the UK is actually 20 m shorter than was thought ten years ago, before the Global Positioning Satellite system was in operation. Attendance at the lectures is free and schools interested in booking tickets should visit the Faraday website at www.faraday.org.uk . Further details of the tour are available from the Faraday Lecture Office, Institution of Electrical Engineers, Michael Faraday House, Six Hills Way, Stevenage, Herts SG1 2AY (tel: 01438 313311, fax: 01438 742856, e-mail: faraday@iee.org.uk ). Among the `Strands' on the programme at the 2000 Edinburgh international science festival on 2 - 18 April are: visions of the future; time; the natural world; new materials; science book festival; science film festival. Festival programmes should be available soon from the festival office at 8 Lochend Road, Edinburgh EH6 8BR (tel: 0131 530 2001, fax: 0131 530 2002, e-mail: esf@scifest.demon.co.uk ). BA2000 will be one of the key features of the `creating SPARKS' festival where the sciences meet the arts in London during 6 - 30 September. Centred on South Kensington, and led by the British Association, creating SPARKS will be staged at such famous institutions as Imperial College, the Royal Albert Hall, the Royal College of Art, the Natural History and Science Museums and the Royal Geographical Society. Under the heading `Shaping the future together' BA2000 will explore science, engineering and technology in their wider cultural context. Further information about this event on 6 - 12 September may be obtained from Sandra Koura, BA2000 Festival Manager, British Association for the Advancement of Science, 23 Savile Row, London W1X 2NB (tel: 0171 973 3075, e-mail: sandra.koura@britassoc.org.uk ). Details of the creating SPARKS events may be obtained from creating.sparks@britassoc.org.uk or from the website www.britassoc.org.uk . Other events 3 - 7 July, Porto Alegre, Brazil VII Interamerican conference on physics education: The preparation of physicists and physics teachers in contemporary society. Info: IACPE7@if.ufrgs.br or cabbat1.cnea.gov.ar/iacpe/iacpei.htm 27 August - 1 September, Barcelona, Spain GIREP conference: Physics teacher education beyond 2000. Info: www.blues.uab.es/phyteb/index.html

32 CFR 555.2 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Experiment Station (WES), the U.S. Army Construction Engineering Research Laboratory (CERL), the U.S. Army Engineer Topographic Laboratories (ETL), the U.S. Army Coastal Engineering Research Center (CERC), the U.S... CEMETERIES CORPS OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY RESEARCH AND DEVELOPMENT AND TESTS, WORK...

Orbital fitting of imaged planetary companions with high eccentricities and unbound orbits. Their application to Fomalhaut b and PZ Telecopii B

NASA Astrophysics Data System (ADS)

Beust, H.; Bonnefoy, M.; Maire, A.-L.; Ehrenreich, D.; Lagrange, A.-M.; Chauvin, G.

2016-03-01

Context. Regular follow-up of imaged companions to main-sequence stars often allows a projected orbital motion to be detected. Markov chain Monte Carlo (MCMC) has become very popular recent years for fitting and constraining their orbits. Some of these imaged companions appear to move on very eccentric, possibly unbound orbits. This is, in particular, the case for the exoplanet Fomalhaut b and the brown dwarf companion PZ Tel B on which we focus here. Aims: For these orbits, standard MCMC codes that assume only bound orbits may be inappropriate. Our goal is to develop a new MCMC implementation that is able to handle both bound and unbound orbits in a continuous manner, and to apply this to the cases of Fomalhaut b and PZ Tel B. Methods: We present here this code, based on the use of universal Keplerian variables and Stumpff functions. We present two versions of this code, the second one using a different set of angular variables that were designed to avoid degeneracies arising when the projected orbital motion is quasi-radial, as is the case for PZ Tel B. We also present additional observations of PZ Tel B. Results: The code is applied to Fomalhaut b and PZ Tel B. We confirm previous results in relation to, but we show that on the sole basis of the astrometric data, open orbital solutions are also possible. The eccentricity distribution nevertheless still peaks around ~0.9 in the bound regime. We present a first successful orbital fit of PZ Tel B, which shows in particular that, while both bound and unbound orbital solutions are equally possible, the eccentricity distribution presents a sharp peak very close to e = 1, meaning a quasi-parabolic orbit. Conclusions: It has recently been suggested that the presence of unseen inner companions to imaged ones may lead orbital fitting algorithms to artificially give very high eccentricities. We show that this caveat is unlikely to apply to Fomalhaut b. Concerning PZ Tel B, we derive a possible solution, which involves an inner ~12 MJup companion, that would mimic a e = 1 orbit, despite a real eccentricity of around 0.7, but a dynamical analysis reveals that this type of system would not be stable. We thus conclude that our orbital fit is robust. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere, Chile (Program ID: 085.C-0867(B) and 085.C-0277(B)).

Benchmark cool companions: ages and abundances for the PZ Telescopii system

NASA Astrophysics Data System (ADS)

Jenkins, J. S.; Pavlenko, Y. V.; Ivanyuk, O.; Gallardo, J.; Jones, M. I.; Day-Jones, A. C.; Jones, H. R. A.; Ruiz, M. T.; Pinfield, D. J.; Yakovina, L.

2012-03-01

We present new ages and abundance measurements for the pre-main-sequence star PZ Telescopii (more commonly known as PZ Tel). PZ Tel was recently found to host a young and low-mass companion. Such companions, whether they are brown dwarfs or planetary systems, can attain benchmark status by detailed study of the properties of the primary, and then evolutionary and bulk characteristics can be inferred for the companion. Using Fibre-fed Extended Range Optical Spectrograph spectra, we have measured atomic abundances (e.g. Fe and Li) and chromospheric activity for PZ Tel and used these to obtain the metallicity and age estimates for the companion. We have also determined the age independently using the latest evolutionary models. We find PZ Tel A to be a rapidly rotating (v sin i= 73 ± 5 km s-1), approximately solar metallicity star [log N(Fe) =-4.37 ± 0.06 dex or [Fe/H] = 0.05 ± 0.20 dex]. We measure a non-local thermodynamic equilibrium lithium abundance of log N(Li) = 3.1 ± 0.1 dex, which from depletion models gives rise to an age of 7? Myr for the system. Our measured chromospheric activity (? of -4.12) returns an age of 26 ± 2 Myr, as does fitting pre-main-sequence evolutionary tracks (τevol= 22 ± 3 Myr), both of these are in disagreement with the lithium age. We speculate on reasons for this difference and introduce new models for lithium depletion that incorporate both rotation and magnetic field effects. We also synthesize solar, metal-poor and metal-rich substellar evolutionary models to better determine the bulk properties of PZ Tel B, showing that PZ Tel B is probably more massive than previous estimates, meaning the companion is not a giant exoplanet, even though a planetary-like formation origin can go some way to describing the distribution of benchmark binaries currently known. We show how PZ Tel B compares to other currently known age and metallicity benchmark systems and try to empirically test the effects of dust opacity as a function of metallicity on the near-infrared colours of brown dwarfs. Current models suggest that in the near-infrared observations are more sensitive to low-mass companions orbiting more metal rich stars. We also look for trends between infrared photometry and metallicity amongst a growing population of substellar benchmark objects, and identify the need for more data in mass-age-metallicity parameter space.

77 FR 39559 - In the Matter of AngelCiti Entertainment, Inc., BodyTel Scientific, Inc., Clearant, Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

...., BodyTel Scientific, Inc., Clearant, Inc., DataMetrics Corp., and Green Energy Group, Inc. (a/k/a eCom eCom.Com, Inc.); Order of Suspension of Trading June 29, 2012. It appears to the Securities and... of current and accurate information concerning the securities of Green Energy Group, Inc. (a/k/a eCom...

First photometric study of two southern eclipsing binaries IS Tel and DW Aps

NASA Astrophysics Data System (ADS)

Özer, S.; Sürgit, D.; Erdem, A.; Öztürk, O.

2017-02-01

The paper presents the first photometric analysis of two southern eclipsing binary stars, IS Tel and DW Aps. Their V light curves from the All Sky Automated Survey were modelled by using Wilson-Devinney method. The final models give these two Algol-like binary stars as having detached configurations. Absolute parameters of the components of the systems were also estimated.

The effect of an interactive weekly mobile phone messaging on retention in prevention of mother to child transmission (PMTCT) of HIV program: study protocol for a randomized controlled trial (WELTEL PMTCT).

PubMed

Awiti, Patricia Opondo; Grotta, Alessandra; van der Kop, Mia; Dusabe, John; Thorson, Anna; Mwangi, Jonathan; Belloco, Rino; Lester, Richard; Ternent, Laura; Were, Edwin; Ekström, Anna Mia

2016-07-11

Improving retention in prevention of mother to child transmission (PMTCT) of HIV programs is critical to optimize maternal and infant health outcomes, especially now that lifelong treatment is immediate regardless of CD4 cell count). The WelTel strategy of using weekly short message service (SMS) to engage patients in care in Kenya, where mobile coverage even in poor areas is widespread has been shown to improve adherence to antiretroviral therapy (ART) and viral load suppression among those on ART. The aim of this study is to determine the effect of the WelTel SMS intervention compared to standard care on retention in PMTCT program in Kenya. WelTel PMTCT is a four to seven-centers, two-arm open randomized controlled trial (RCT) that will be conducted in urban and rural Kenya. Over 36 months, we plan to recruit 600 pregnant women at their first antenatal care visit and follow the mother-infant pair until they are discharged from the PMTCT program (when infant is aged 24 months). Participants will be randomly allocated to the intervention or control arm (standard care) at a 1:1 ratio. Intervention arm participants will receive an interactive weekly SMS 'How are you?' to which they are supposed to respond within 24 h. Depending on the response (ok, problem or no answer), a PMTCT nurse will follow-up and triage any problems that are identified. The primary outcome will be retention in care defined as the proportion of mother-infant pairs coming for infant HIV testing at 24 months from delivery. Secondary outcomes include a) adherence to WelTel; (b) adherence to antiretroviral medicine; (c) acceptance of WelTel and (d) cost-effectiveness of the WelTel intervention. This trial will provide evidence on the effectiveness of mHealth for PMTCT retention. Trial results and the cost-effectiveness evaluation will be used to inform policy and potential scale-up of mHealth among mothers living with HIV. ISRCTN98818734 ; registered on 9th December 2014.

Software Engineering Laboratory Series: Proceedings of the Twentieth Annual Software Engineering Workshop

NASA Technical Reports Server (NTRS)

1995-01-01

The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

Software Engineering Laboratory Series: Collected Software Engineering Papers. Volume 15

NASA Technical Reports Server (NTRS)

1997-01-01

The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

Software Engineering Laboratory Series: Collected Software Engineering Papers. Volume 14

NASA Technical Reports Server (NTRS)

1996-01-01

The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

Software Engineering Laboratory Series: Collected Software Engineering Papers. Volume 13

NASA Technical Reports Server (NTRS)

1995-01-01

The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

Swept Source OCT Angiography of Neovascular Macular Telangiectasia Type 2

PubMed Central

Zhang, Qinqin; Wang, Ruikang K.; Chen, Chieh-Li; Legarreta, Andrew D.; Durbin, Mary K.; An, Lin; Sharma, Utkarsh; Stetson, Paul F.; Legarreta, John E.; Roisman, Luiz; Gregori, Giovanni; Rosenfeld, Philip J.

2015-01-01

Objective To image subretinal neovascularization in proliferative macular telangiectasia type 2 (MacTel2) using swept source optical coherence tomography based microangiography (OMAG). Study Design Patients with MacTel2 were enrolled in a prospective, observational study known as the MacTel Project and evaluated using a high-speed 1050nm swept-source OCT (SS-OCT) prototype system. The OMAG algorithm generated en face flow images from three retinal layers, as well as the region bounded by the outer retina and Bruch’s membrane, the choriocapillaris, and the remaining choroidal vasculature. The en face OMAG images were compared to images from fluorescein angiography (FA) and indocyanine green angiography (ICGA). Results Three eyes with neovascular MacTel2 were imaged. The neovascularization was best identified from the en face OMAG images that included a layer between the outer retinal boundary and Bruch’s membrane. OMAG images identified these abnormal vessels better than FA and were comparable to the images obtained using ICGA. In all three cases, OMAG identified choroidal vessels communicating with the neovascularization, and these choroidal vessels were evident in the two cases with ICGA imaging. In one case, monthly injections of bevacizumab reduced the microvascular complexity of the neovascularization, as well as the telangiectatic changes within the retinal microvasculature. In another case, less frequent bevacizumab therapy was associated with growth of the subretinal neovascular complex. Conclusions OMAG imaging provided detailed, depth-resolved information about subretinal neovascularization in MacTel2 eyes demonstrating superiority to FA imaging and similarities to ICGA imaging for documenting the retinal microvascular changes, the size and extent of the neovascular complex, the communications between the neovascular complex and the choroidal circulation, and the response to monthly bevacizumab therapy. PMID:26457402

Radical-induced purine lesion formation is dependent on DNA helical topology.

PubMed

Terzidis, Michael A; Prisecaru, Andreea; Molphy, Zara; Barron, Niall; Randazzo, Antonio; Dumont, Elise; Krokidis, Marios G; Kellett, Andrew; Chatgilialoglu, Chryssostomos

2016-11-01

Herein we report the quantification of purine lesions arising from gamma-radiation sourced hydroxyl radicals (HO • ) on tertiary dsDNA helical forms of supercoiled (SC), open circular (OC), and linear (L) conformation, along with single-stranded folded and non-folded sequences of guanine-rich DNA in selected G-quadruplex structures. We identify that DNA helical topology and folding plays major, and unexpected, roles in the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) and 8-oxo-7,8-dihydro-2'-deoxyadenosine (8-oxo-dA), along with tandem-type purine lesions 5',8-cyclo-2'-deoxyguanosine (5',8-cdG) and 5',8-cyclo-2'-deoxyadenosine (5',8-cdA). SC, OC, and L dsDNA conformers together with folded and non-folded G-quadruplexes d[TGGGGT] 4 (TG4T), d[AGGG(TTAGGG) 3 ] (Tel22), and the mutated tel24 d[TTGGG(TTAGGG) 3 A] (mutTel24) were exposed to HO • radicals and purine lesions were then quantified via stable isotope dilution LC-MS/MS analysis. Purine oxidation in dsDNA follows L > OC ≫ SC indicating greater damage towards the extended B-DNA topology. Conversely, G-quadruplex sequences were significantly more resistant toward purine oxidation in their unfolded states as compared with G-tetrad folded topologies; this effect is confirmed upon comparative analysis of Tel22 (∼50% solution folded) and mutTel24 (∼90% solution folded). In an effort to identify the accessibly of hydroxyl radicals to quadruplex purine nucleobases, G-quadruplex solvent cavities were then modeled at 1.33 Å with evidence suggesting that folded G-tetrads may act as potential oxidant traps to protect against chromosomal DNA damage.

Ten-year experiences on initial genetic examination in childhood acute lymphoblastic leukaemia in Hungary (1993-2002). Technical approaches and clinical implementation.

PubMed

Olah, Eva; Balogh, Erzsebet; Pajor, Laszlo; Jakab, Zsuzsanna

2011-03-01

A nationwide study was started in 1993 to provide genetic diagnosis for all newly diagnosed childhood ALL cases in Hungary using cytogenetic examination, DNA-index determination, FISH (aneuploidy, ABL/BCR, TEL/AML1) and molecular genetic tests (ABL/BCR, MLL/AF4, TEL/AML1). Aim of the study was to assess the usefulness of different genetic methods, to study the frequency of various aberrations and their prognostic significance. Results were synthesized for genetic subgrouping of patients. To assess the prognostic value of genetic aberrations overall and event-free survival of genetic subgroups were compared using Kaplan-Meier method. Prognostic role of aberrations was investigated by multivariate analysis (Cox's regression) as well in comparison with other factors (age, sex, major congenital abnormalities, initial WBC, therapy, immunophenotype). Five hundred eighty-eight ALL cases were diagnosed between 1993-2002. Cytogenetic examination was performed in 537 (91%) (success rate 73%), DNA-index in 265 (45%), FISH in 74 (13%), TEL/AML1 RT-PCR in 219 (37%) cases producing genetic diagnosis in 457 patients (78%). Proportion of subgroups with good prognosis in prae-B-cell ALL was lower than expected: hyperdiploidB 18% (73/400), TEL/AML1+ 9% (36/400). Univariate analysis showed significantly better 5-year EFS in TEL/AML1+ (82%) and hyperdiploidB cases (78%) than in tetraploid (44%) or pseudodiploid (52%) subgroups. By multivariate analysis main negative prognostic factors were: congenital abnormalities, high WBC, delay in therapy, specific translocations. Complementary use of each of genetic methods used is necessary for reliable genetic diagnosis according to the algorithm presented. Specific genetic alterations proved to be of prognostic significance.

First-year Engineering Education with the Creative Electrical Engineering Laboratory

NASA Astrophysics Data System (ADS)

Tsukamoto, Takehiko; Sugito, Tetsumasa; Ozeki, Osamu; Ushiroda, Sumio

The Department of Electrical and Electronic Engineering in Toyota National College of Technology has put great emphasis on fundamental subjects. We introduced the creative electrical engineering laboratory into the first-year engineering education since 1998. The laboratory concentrates on the practice exercise. The final questionnaire of students showed that our first-year education is very effective to promote students motivation and their scholastic ability in engineering.

OCT Angiography Helps Distinguish Between Proliferative Macular Telangiectasia Type 2 and Neovascular Age-Related Macular Degeneration.

PubMed

Zheng, Fang; Motulsky, Elie H; de Oliveira Dias, João Rafael; de López, Edith Pérez; Gregori, Giovanni; Rosenfeld, Philip J

2018-05-01

To demonstrate the advantage of optical coherence tomography angiography (OCTA) for the diagnosis and management of proliferative macular telangiectasia type 2 (MacTel2) masquerading as neovascular age-related macular degeneration (AMD). This is an observational cases series. Three patients referred with the diagnosis of neovascular AMD were identified in this retrospective study. In addition to color fundus, fluorescein angiography, and spectral-domain OCT (SD-OCT) imaging, SD-OCTA (AngioPlex; Carl Zeiss Meditec, Dublin, CA) was performed. SD-OCTA revealed bilateral parafoveal retinal microvascular changes in three patients and unambiguously confirmed the diagnosis of MacTel2. OCTA is an important tool for the correct diagnosis of MacTel2 in older patients with the concomitant or masquerading diagnosis of AMD. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:303-312.]. Copyright 2018, SLACK Incorporated.

Software Engineering Laboratory Series: Proceedings of the Twenty-First Annual Software Engineering Workshop

NASA Technical Reports Server (NTRS)

1996-01-01

The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

Software Engineering Laboratory Series: Proceedings of the Twenty-Second Annual Software Engineering Workshop

NASA Technical Reports Server (NTRS)

1997-01-01

The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

VERIFI | Virtual Engine Research Institute and Fuels Initiative

Science.gov Websites

VERIFI Virtual Engine Research Institute and Fuels Initiative Argonne National Laboratory Skip to Virtual Engine Research Institute and Fuels Initiative (VERIFI) at Argonne National Laboratory is the Argonne National Laboratory in which to answer your complex engine questions, verify the uncertainties

The Formation of Indicators on Engineering Laboratory Management

ERIC Educational Resources Information Center

Yasin, Ruhizan M.; Mohamad, Zunuwanas; Rahman, Mohd Nizam Ab.; Hashim, Mohamad Hisyam Mohd

2012-01-01

This research is a developmental study of Engineering Laboratory Management indicators. It is formed to assess the level of quality management of the polytechnic level laboratory. The purpose of indicators is to help provide input into the management process of an engineering laboratory. Effectiveness of teaching and learning at technical…

Software engineering laboratory series: Annotated bibliography of software engineering laboratory literature

NASA Technical Reports Server (NTRS)

Morusiewicz, Linda; Valett, Jon

1992-01-01

This document is an annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory. More than 100 publications are summarized. These publications cover many areas of software engineering and range from research reports to software documentation. This document has been updated and reorganized substantially since the original version (SEL-82-006, November 1982). All materials have been grouped into eight general subject areas for easy reference: (1) the Software Engineering Laboratory; (2) the Software Engineering Laboratory: Software Development Documents; (3) Software Tools; (4) Software Models; (5) Software Measurement; (6) Technology Evaluations; (7) Ada Technology; and (8) Data Collection. This document contains an index of these publications classified by individual author.

Expanding the Scope of Anatomical Sciences: The Case of "Human Evolution--The Fossil Evidence" Course at the Sackler School of Medicine, Tel-Aviv University

ERIC Educational Resources Information Center

Notzer, Netta; Abramovitz, Ruth

2012-01-01

The Anatomy Department at Tel-Aviv University Medical School offers its students an elective course of 26 didactic hours on human evolution. The course is open to students from all faculties, who must fulfill all academic requirements, without a prerequisite of a background in anatomy. Approximately 120 students attend annually, a third of them…

Advanced Computational Models for Fabric-Reinforced Composites

DTIC Science & Technology

2001-10-01

composites. Trans-Science Corporation 3655 Nobel Drive Suite 440 San Diego, CA 92122-1005 Tel (858) 459-1240 http://www.compositesolutionsinc.com...also based in XP! Material Suppliers San Diego, recently developed the only Newsletters comprehensive design software for the seismic NDT, NDE , NDI...composite bus. Trans-Science Corporation 3655 Nobel Drive Suite 440 San Diego, CA 92122-1005 Tel (858) 459-1240 Fax (858) 459-0210 •’(S-HOME SERVICES

Beneath Our Eyes: An Exploration of the Relationship between Technology Enhanced Learning and Socio-Ecological Sustainability in Art and Design Higher Education

ERIC Educational Resources Information Center

Sclater, Madeleine

2016-01-01

This article uses published research to explore how Technology Enhanced Learning (TEL) can help to sustain learning communities to engage in creative exploration and open investigation. It then draws on this research to ask: how could we use TEL to support pedagogies of socio-ecological sustainability in the Art and Design education community?…

Adaptive Learning in Medical Education: The Final Piece of Technology Enhanced Learning?

PubMed

Sharma, Neel; Doherty, Iain; Dong, Chaoyan

2017-09-01

Technology enhanced learning (TEL) is now common practice in the field of medical education. One of the primary examples of its use is that of high fidelity simulation and computerised mannequins. Further examples include online learning modules, electronic portfolios, virtual patient interactions, massive open online courses and the flipped classroom movement. The rise of TEL has occurred primarily due to the ease of internet access enabling the retrieval and sharing of information in an instant. Furthermore, the compact nature of internet ready devices such as smartphones and laptops has meant that access to information can occur anytime and anywhere. From an educational perspective however, the current utilisation of TEL has been hindered by its lack of understanding of learners' needs. This is concerning, particularly as evidence highlights that during medical training, each individual learner has their own learning requirements and often achieves competency at different rates. In view of this, there has been interest in ensuring TEL is more learner aware and that the learning process should be more personalised. Adaptive learning can aim to achieve this by ensuring content is delivered according to the needs of the learner. This commentary highlights the move towards adaptive learning and the benefits of such an intervention.

Structural basis of sodium–potassium exchange of a human telomeric DNA quadruplex without topological conversion

PubMed Central

Wang, Zi-Fu; Li, Ming-Hao; Hsu, Shang-Te Danny; Chang, Ta-Chau

2014-01-01

Understanding the mechanism of Na+/K+-dependent spectral conversion of human telomeric G-quadruplex (G4) sequences has been limited not only because of the structural polymorphism but also the lack of sufficient structural information at different stages along the conversion process for one given oligonucleotide. In this work, we have determined the topology of the Na+ form of Tel23 G4, which is the same hybrid form as the K+ form of Tel23 G4 despite the distinct spectral patterns in their respective nuclear magnetic resonance (NMR) and circular dichroism spectra. The spectral difference, particularly the well-resolved imino proton NMR signals, allows us to monitor the structural conversion from Na+ form to K+ form during Na+/K+ exchange. Time-resolved NMR experiments of hydrogen–deuterium exchange and hybridization clearly exclude involvement of the global unfolding for the fast Na+/K+ spectral conversion. In addition, the K+ titration monitored by NMR reveals that the Na+/K+ exchange in Tel23 G4 is a two-step process. The addition of K+ significantly stabilizes the unfolding kinetics of Tel23 G4. These results offer a possible explanation of rapid spectral conversion of Na+/K+ exchange and insight into the mechanism of Na+/K+ structural conversion in human telomeric G4s. PMID:24476914

The T-TEL Method for Assessing Water, Sediment, and Chemical Connectivity

NASA Astrophysics Data System (ADS)

Ali, Genevieve; Oswald, Claire; Spence, Christopher; Wellen, Christopher

2018-02-01

The concept of connectivity has been the subject of a great deal of recent research and provided new insights and breakthroughs on runoff generation processes and watershed biogeochemistry. However, a consensus definition and cohesive mathematical framework that would permit the consistent quantification of hydrologic connectivity, the examination of the interrelationships between water and material (e.g., sediment and chemicals) connectivity, or rigorous study intercomparison, have not been presented by the water resource community. Building on previous conceptualizations and site-specific or process-specific metrics, this paper aimed to review the current state of science on hydrologic connectivity and its role in water-mediated connectivity of material such as solutes and sediment before introducing a conceptual and a mathematical connectivity assessment framework. These frameworks rely on the quantification of Time scales, Thresholds, Excesses and Losses related to water and water-mediated material transport dynamics and are referred to as the T-TEL method. Through a small case study, we show how the T-TEL method allows a wide range of properties to be quantified, namely the occurrence, frequency, duration, magnitude, and spatial extent of water and water-mediated material connectivity. We also propose a research agenda to refine the T-TEL method and ensure its usefulness for facilitating the research and management of connectivity in pristine and human-impacted landscapes.

Draftsmen at Work during Construction of the Aircraft Engine Research Laboratory

NASA Image and Video Library

1942-09-21

The National Advisory Committee for Aeronautics (NACA) Aircraft Engine Research Laboratory was designed by a group of engineers at the Langley Memorial Aeronautical Laboratory in late 1940 and 1941. Under the guidance of Ernest Whitney, the men worked on drawings and calculations in a room above Langley’s Structural Research Laboratory. The main Aircraft Engine Research Laboratory design group originally consisted of approximately 30 engineers and draftsmen, but there were smaller groups working separately on specific facilities. The new engine lab would have six principal buildings: the Engine Research Building, hangar, Fuels and Lubricants Building, Administration Building, Propeller Test Stand, and Altitude Wind Tunnel. In December 1941 most of those working on the project transferred to Cleveland from Langley. Harrison Underwood and Charles Egan led 18 architectural, 26 machine equipment, 3 structural and 10 mechanical draftsmen. Initially these staff members were housed in temporary offices in the hangar. As sections of the four-acre Engine Research Building were completed in the summer of 1942, the design team began relocating there. The Engine Research Building contained a variety of test cells and laboratories to address virtually every aspect of piston engine research. It also contained a two-story office wing, seen in this photograph that would later house many of the powerplant research engineers.

Annotated bibliography of Software Engineering Laboratory literature

NASA Technical Reports Server (NTRS)

Morusiewicz, Linda; Valett, Jon D.

1991-01-01

An annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory is given. More than 100 publications are summarized. These publications cover many areas of software engineering and range from research reports to software documentation. All materials have been grouped into eight general subject areas for easy reference: The Software Engineering Laboratory; The Software Engineering Laboratory: Software Development Documents; Software Tools; Software Models; Software Measurement; Technology Evaluations; Ada Technology; and Data Collection. Subject and author indexes further classify these documents by specific topic and individual author.

Technology Transfer of the Air Quality Assessment Model.

DTIC Science & Technology

1984-02-01

i T I, _______ ENGINEERING & SERVICES LABORATORY AIR FORCE ENGINEERING & SERVICES CENTER TYNOALL AIR FORCE BASE. FLORIDA 32403 OTIC FILE CO84 03...30 015 NOTICE PLEASE DO NOT REQUEST COPIES OF THIS REPORT FRO(M HQ AFESC./RD ( ENGINEERING AND SERVICES LABORATORY). ADDITONAL COPIES MAY BE PURCHASED...report was prepared by the Air Force Engineering and Services Center, Engineering and Services Laboratory, (AFESC/ RDV) Tyndall AFB, FL. This report

Glocalized New Age Spirituality: A Mental Map of the New Central Bus Station in Tel Aviv, Deciphered through Its Visual Codes and Based on Ethno-Visual Research

ERIC Educational Resources Information Center

Ben-Peshat, Malka; Sitton, Shoshana

2011-01-01

We present here the findings of an ethno-visual research study involving the creation of a mental map of images, artifacts and practices in Tel Aviv's New Central Bus Station. This huge and complex building, part bus station, part shopping mall, has become a stage for multicultural encounters and interactions among diverse communities of users.…

Field Applications of In Situ Remediation Technologies: Permeable Reactive Barriers

DTIC Science & Technology

2002-01-01

dweymann@ emconinc.com Caldwell Trucking Northern NJ 1998 TCE Hydraulic Fracturing , $1.12 M Fe0 Only 60% John Vidumsky Permeation Infilling...Oriented $1.15 M Granular No problems except Stephen H. Shoemaker Chloroform, Freon 11, Hydraulic Fracturing cast iron at recovering an Tel: 704-362...VC Massachusetts Falmouth, MA 1998 PCE, TCE Hydraulic Fracturing $160 K Fe0 Robert W. Gillham Military Reservation Tel: 519-888-4658 CS-10 Plume Fax

Studying the Immunomodulatory Effects of Small Molecule Ras-Inhibitors in Animal Models of Rheumatoid Arthritis

DTIC Science & Technology

2015-10-01

Models of Rheumatoid Arthritis PRINCIPAL INVESTIGATOR: Yoel Kloog RECIPIENT: Tel Aviv University TEL AVIV 69978 Israel REPORT DATE: October...TITLE AND SUBTITLE Studying the Immunomodulatory Effects of Small Molecule Ras- Inhibitors in Animal Models of Rheumatoid Arthritis 5a. CONTRACT NUMBER... Rheumatoid Arthritis (RA) display augmented activation of the Ras/Raf/MEK/ERK1/2 signaling pathway, and accordingly overexpression of active K-RAS in

Anion-Driven Self-Assembly Processes Based on Halogen-Bonding

DTIC Science & Technology

2007-07-10

23993041 Fax: +39-02-23993180 E-mail: pierangelo.metrangolo@polimi.it Sede Leonardo : Piazza L.Da Vinci , 32 – 20133 Milano Tel. ++39-02...02-23993180 E-mail: pierangelo.metrangolo@polimi.it Sede Leonardo : Piazza L.Da Vinci , 32 – 20133 Milano Tel. ++39-02 2399.3200 Fax ++39-02...Pierangelo Metrangolo Ph. +39-02-23993041 Fax: +39-02-23993180 E-mail: pierangelo.metrangolo@polimi.it Sede Leonardo : Piazza L.Da Vinci , 32

The Dialectics of Assimilation and Multiculturalism: The Case of Children of Refugees and Migrant Workers in the Bialik-Rogozin School, Tel Aviv

ERIC Educational Resources Information Center

Dvir, Nurit; Aloni, Nimrod; Harari, Dor

2015-01-01

This paper focuses on children of refugees and migrant workers from 48 countries who study together in one multicultural school in the city of Tel Aviv, Israel. The context of our study is the current ethos of globalisation and within it the phenomenon of vast migrations and creation of intercultural social realities. The aims of the study were to…

An Enzyme-Catalyzed Multistep DNA Refolding Mechanism in Hairpin Telomere Formation

PubMed Central

Shi, Ke; Huang, Wai Mun; Aihara, Hideki

2013-01-01

Hairpin telomeres of bacterial linear chromosomes are generated by a DNA cutting–rejoining enzyme protelomerase. Protelomerase resolves a concatenated dimer of chromosomes as the last step of chromosome replication, converting a palindromic DNA sequence at the junctions between chromosomes into covalently closed hairpins. The mechanism by which protelomerase transforms a duplex DNA substrate into the hairpin telomeres remains largely unknown. We report here a series of crystal structures of the protelomerase TelA bound to DNA that represent distinct stages along the reaction pathway. The structures suggest that TelA converts a linear duplex substrate into hairpin turns via a transient strand-refolding intermediate that involves DNA-base flipping and wobble base-pairs. The extremely compact di-nucleotide hairpin structure of the product is fully stabilized by TelA prior to strand ligation, which drives the reaction to completion. The enzyme-catalyzed, multistep strand refolding is a novel mechanism in DNA rearrangement reactions. PMID:23382649

Flight and Test-stand Investigation of High-performance Fuels in Modified Double-row Radial Air-cooled Engines III: Knock-limited Performance of 33-R as Compared with a Triptane Blend and 28-R in Flight

NASA Technical Reports Server (NTRS)

Blackman, Calvin C.; White, H. Jack

1945-01-01

A comparison has been made in flight of the antiknock characteristics of 33-R fuel with that of 28-R and a triptane blent. The knock-limited performance of the three fuels - 33-R, a blend of 80 percent 28-R plus 20 percent triptane (leaded to 4.5 ml TEL/gal), and 28-R - was investigated in two modified 14-cylinder double-row radial air-cooled engines. Tests were conducted on the engines as installed in the left inboard nacelle of an airplane. A carburetor-air temperature of approximately 85 deg F was maintained. The conditions covered at an engine speed of 2250 rpm were high and low blower ratios and spark advances of 25 deg and 32 deg B.T.C. For an engine speed of 1800 rpm only the high-blower condition was investigated for both 25 deg and 32 deg spark advances. For the conditions investigated the difference between 33-R and the triptane blend was found to be slight; the performance of 33-R fuel, however, was slightly higher than that of the triptane blend in the lean region. The knock-limited power obtained with the 33-R fuel was from 14 to 28 percent higher than that of the 28-R fuel for the entire range of test conditions; the greatest improvement was shown in the lean region.

Stirling laboratory research engine survey report

NASA Technical Reports Server (NTRS)

Anderson, J. W.; Hoehn, F. W.

1979-01-01

As one step in expanding the knowledge relative to and accelerating the development of Stirling engines, NASA, through the Jet Propulsion Laboratory (JPL), is sponsoring a program which will lead to a versatile Stirling Laboratory Research Engine (SLRE). An objective of this program is to lay the groundwork for a commercial version of this engine. It is important to consider, at an early stage in the engine's development, the needs of the potential users so that the SLRE can support the requirements of educators and researchers in academic, industrial, and government laboratories. For this reason, a survey was performed, the results of which are described.

Low-Cost Virtual Laboratory Workbench for Electronic Engineering

ERIC Educational Resources Information Center

Achumba, Ifeyinwa E.; Azzi, Djamel; Stocker, James

2010-01-01

The laboratory component of undergraduate engineering education poses challenges in resource constrained engineering faculties. The cost, time, space and physical presence requirements of the traditional (real) laboratory approach are the contributory factors. These resource constraints may mitigate the acquisition of meaningful laboratory…

Laboratory Manual, Electrical Engineering 25.

ERIC Educational Resources Information Center

Syracuse Univ., NY. Dept. of Electrical Engineering.

Developed as part of a series of materials in the electrical engineering sequence developed under contract with the United States Office of Education, this laboratory manual provides nine laboratory projects suitable for a second course in electrical engineering. Dealing with resonant circuits, electrostatic fields, magnetic devices, and…

40 CFR 1065.920 - PEMS Calibrations and verifications.

Code of Federal Regulations, 2010 CFR

2010-07-01

... POLLUTION CONTROLS ENGINE-TESTING PROCEDURES Field Testing and Portable Emission Measurement Systems § 1065... verification. The verification consists of operating an engine over a duty cycle in the laboratory and... by laboratory equipment as follows: (1) Mount an engine on a dynamometer for laboratory testing...

JPRS Report, Near East & South Asia

DTIC Science & Technology

1990-11-28

REGIONAL AFFAIRS King Husayn’s Control Over Islamic Factions Questioned tal411182a Tel Aviv HADASHOT in Hebrew 14 Nov 90 p 2 [Text] Yesterday...kingdom. PALESTINIAN AFFAIRS Removal of Israeli Authority Said to Be Goal 91AE0018B Tel Aviv HADASHOT (Weekend Supplement) in Hebrew 7 Sep 90 p 12...holy places and become excited like a romantic virgin upon hearing the names of places from the Bible . You do not really understand this, because

Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2

PubMed Central

Tsabar, Michael; Eapen, Vinay V.; Mason, Jennifer M.; Memisoglu, Gonen; Waterman, David P.; Long, Marcus J.; Bishop, Douglas K.; Haber, James E.

2015-01-01

In response to chromosomal double-strand breaks (DSBs), eukaryotic cells activate the DNA damage checkpoint, which is orchestrated by the PI3 kinase-like protein kinases ATR and ATM (Mec1 and Tel1 in budding yeast). Following DSB formation, Mec1 and Tel1 phosphorylate histone H2A on serine 129 (known as γ-H2AX). We used caffeine to inhibit the checkpoint kinases after DSB induction. We show that prolonged phosphorylation of H2A-S129 does not require continuous Mec1 and Tel1 activity. Unexpectedly, caffeine treatment impaired homologous recombination by inhibiting 5′ to 3′ end resection, independent of Mec1 and Tel1 inhibition. Caffeine treatment led to the rapid loss, by proteasomal degradation, of both Sae2, a nuclease that plays a role in early steps of resection, and Dna2, a nuclease that facilitates one of two extensive resection pathways. Sae2's instability is evident in the absence of DNA damage. A similar loss is seen when protein synthesis is inhibited by cycloheximide. Caffeine treatment had similar effects on irradiated HeLa cells, blocking the formation of RPA and Rad51 foci that depend on 5′ to 3′ resection of broken chromosome ends. Our findings provide insight toward the use of caffeine as a DNA damage-sensitizing agent in cancer cells. PMID:26019182

Survey of Oral Health Awareness in Neuchâtel 9th Graders.

PubMed

Neuhaus, Klaus W; Müller, Magali E; Lussi, Adrian

The oral health habits of pupils had not yet been analyzed for the canton of Neuchâtel. A questionnaire was provided to 9th grade high school pupils (final year) of the three schools located in the Neuchâtel area to asses both oral health knowledge and habits in this connection. The average age was 15.5±0.8 years, and 78.1% of the questionnaires were returned. The prophylaxis program was conducted for a total of 4.5 h during pupils’ entire time at school. The results showed that both knowledge and oral health habits could be improved. As a positive outcome, 99% of the pupils brush their teeth before going to bed. Comparisons with similar 10-year-old studies from other cantons (Bern, Vaud) showed major differences in knowledge, for example on the importance of fluoridation. Only 54% of the pupils in Neuchâtel knew that fluoride offers some protection against caries, in spite of the fact that 89% thought that brushing with fluoridated toothpaste protects against caries. Most of the pupils used a fluoridated toothpaste. Furthermore, we found that self-reported sugar consumption was correlated with caries experience, but brushing frequency was not. We recommend introducing a review course for pupils in their last school year, in order to practice interdental cleaning, redefine appropriate, tooth-friendly snacks, and emphasize the importance of regular dental check-ups.

Annotated bibliography of software engineering laboratory literature

NASA Technical Reports Server (NTRS)

Groves, Paula; Valett, Jon

1990-01-01

An annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory is given. More than 100 publications are summarized. These publications cover many areas of software engineering and range from research reports to software documentation. This document has been updated and reorganized substantially since the original version (SEL-82-006, November 1982). All materials have been grouped into eight general subject areas for easy reference: the Software Engineering Laboratory; the Software Engineering Laboratory-software development documents; software tools; software models; software measurement; technology evaluations; Ada technology; and data collection. Subject and author indexes further classify these documents by specific topic and individual author.

Annotated bibliography of Software Engineering Laboratory literature

NASA Technical Reports Server (NTRS)

Morusiewicz, Linda; Valett, Jon

1993-01-01

This document is an annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory. Nearly 200 publications are summarized. These publications cover many areas of software engineering and range from research reports to software documentation. This document has been updated and reorganized substantially since the original version (SEL-82-006, November 1982). All materials have been grouped into eight general subject areas for easy reference: the Software Engineering Laboratory; the Software Engineering Laboratory: software development documents; software tools; software models; software measurement; technology evaluations; Ada technology; and data collection. This document contains an index of these publications classified by individual author.

Idaho National Engineering Laboratory, Test Area North, Hangar 629 -- Photographs, written historical and descriptive data

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1994-12-31

The report describes the history of the Idaho National Engineering Laboratory`s Hangar 629. The hangar was built to test the possibility of linking jet engine technology with nuclear power. The history of the project is described along with the development and eventual abandonment of the Flight Engine Test hangar. The report contains historical photographs and architectural drawings.

Fuels and Lubrication Researcher at the Aircraft Engine Research Laboratory

NASA Image and Video Library

1943-08-21

A researcher at the National Advisory Committee for Aeronautics (NACA) Aircraft Engine Research Laboratory studies the fuel ignition process. Improved fuels and lubrication was an area of particular emphasis at the laboratory during World War II. The military sought to use existing types of piston engines in order to get large numbers of aircraft into the air as quickly as possible. To accomplish its goals, however, the military needed to increase the performance of these engines without having to wait for new models or extensive redesigns. The Aircraft Engine Research Laboratory was called on to lead this effort. The use of superchargers successfully enhanced engine performance, but the resulting heat increased engine knock [fuel detonation] and structural wear. These effects could be offset with improved cooling, lubrication, and fuel mixtures. The NACA researchers in the Fuels and Lubrication Division concentrated on new synthetic fuels, higher octane fuels, and fuel-injection systems. The laboratory studied 16 different types of fuel blends during the war, including extensive investigations of triptane and xylidine.

Stirling Laboratory Research Engine: Preprototype configuration report

NASA Technical Reports Server (NTRS)

Hoehn, F. W.

1982-01-01

The concept of a simple Stirling research engine that could be used by industrial, university, and government laboratories was studied. The conceptual and final designs, hardware fabrication and the experimental validation of a preprototype stirling laboratory research engine (SLRE) were completed. Also completed was a task to identify the potential markets for research engines of this type. An analytical effort was conducted to provide a stirling cycle computer model. The versatile engine is a horizontally opposed, two piston, single acting stirling engine with a split crankshaft drive mechanism; special instrumentation is installed at all component interfaces. Results of a thermodynamic energy balance for the system are reported. Also included are the engine performance results obtained over a range of speeds, working pressures, phase angles and gas temperatures. The potential for a stirling research engine to support the laboratory requirements of educators and researchers was demonstrated.

Dr. Johney Green Jr. - Associate Laboratory Director for Mechanical and

Science.gov Websites

Thermal Engineering Sciences | NREL Dr. Johney Green Jr. - Associate Laboratory Director for Mechanical and Thermal Engineering Sciences Dr. Johney Green Jr. - Associate Laboratory Director for Mechanical and Thermal Engineering Sciences A photo of Johney Green In his role, Johney Green oversees early

Annotated bibliography of software engineering laboratory literature

NASA Technical Reports Server (NTRS)

Buhler, Melanie; Valett, Jon

1989-01-01

An annotated bibliography is presented of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory. The bibliography was updated and reorganized substantially since the original version (SEL-82-006, November 1982). All materials were grouped into eight general subject areas for easy reference: (1) The Software Engineering Laboratory; (2) The Software Engineering Laboratory: Software Development Documents; (3) Software Tools; (4) Software Models; (5) Software Measurement; (6) Technology Evaluations; (7) Ada Technology; and (8) Data Collection. Subject and author indexes further classify these documents by specific topic and individual author.

Development of a Combination Therapy for Prostate Cancer by Targeting Stat3 and HIF-1alpha

DTIC Science & Technology

2013-07-01

inflammation-induced cancer, making it an attractive target (25-27). A3. Innovation 1. TEL03 is a novel anti-cancer agent from Chinese herbal medicine ...agents from Chinese herbal medicine (CHM) that targets HIF-1α /2α for prostate cancer therapy. Hypoxia orchestrated by HIF-1αis crucial for tumor...Stat3 for treatment of prostate and other cancers. TEL03, which is a novel anti-cancer agent derived from Chinese herbal medicine (CHM: Hypocrella

JPRS Report, Near East & South Asia

DTIC Science & Technology

1990-11-08

INTERNATIONAL AFFAIRS Undeclared Strategic Agendas in Gulf 91AE0085A Tel Aviv YEDI’OT AHARONOT in Hebrew 30 Oct 90 pp 7, 25 [Article by Ron Ben...faithful representative of the " bible belt" in the southern United States. It is currently difficult to know who initiated the Saudi deals. Was it the...state. JPRS-NEA-90-066 8 NOVEMBER 1990 NEAR EAST 13 ISRAEL Columnist Examines U.S. Middle East Policy 91AE0038B Tel Aviv MA’ARIV in Hebrew

JPRS Report Near East & South Asia

DTIC Science & Technology

1991-03-14

represent the wishes of the Iraqi people. ISRAEL Poll on Territorial Compromise Option Published TA1131501A Tel Aviv YEDI’OT AHARONOT in Hebrew 8...percent Habad Promises To Return Soviet Children TA2122157A Jerusalem Israel Television Network in Hebrew 1900 GMT 21 Feb 91 [Text] The heads of...Agricultural Changes Due to Water Shortage 91AE0252A Tel Aviv MA ’ARIV in Hebrew 25 Jan 91 p2B Second, I think I am entitled to ask the media the following

JPRS Report, Near East & South Asia

DTIC Science & Technology

1991-05-01

sensitive positions in scientific Elections fields, which has enabled them to examine secrets per- 91AE0336A Amman JORDAN TIMES in English taining to...undertaking major Arab development projects, which establish the pillars of an Arab economic 91AE0338C Tel Aviv MA ’ARIV in Hebrew 8 Mar 91...stability of the Middle East. Toward this goal, it is 91AEO329D TelAviv ’ALHAMISHMAR in Hebrew reasonable that it have an interest in a pact with demo- 8

Dynamic Geochemistry of Tetraethyl Lead Dust during the 20th Century: Getting the Lead In, Out, and Translational Beyond

PubMed Central

2018-01-01

This commentary provides a brief overview of policy decisions that permitted getting tetraethyl lead (TEL) into petrol; global geochemical lead-dust deposition evidence; 1975 catalytic converter requirements; concern about habitability of cities; a personal perspective on legacy lead research that accelerated getting TEL out of petrol; and translational beyond, including New Orleans pre- vs. post-Hurricane Katrina observations about legacy lead interventions that effectively improve urban children’s health outcomes. PMID:29701636

Initiation of Research at the Aircraft Engine Research Laboratory

NASA Image and Video Library

1942-05-21

A group of National Advisory Committee for Aeronautics (NACA) officials and local dignitaries were on hand on May 8, 1942, to witness the Initiation of Research at the NACA's new Aircraft Engine Research Laboratory in Cleveland, Ohio. The group in this photograph was in the control room of the laboratory's first test facility, the Engine Propeller Research Building. The NACA press release that day noted, "First actual research activities in what is to be the largest aircraft engine research laboratory in the world was begun today at the National Advisory Committee for Aeronautics laboratory at the Cleveland Municipal Airport.” The ceremony, however, was largely symbolic since most of the laboratory was still under construction. Dr. George W. Lewis, the NACA's Director of Aeronautical Research, and John F. Victory, NACA Secretary, are at the controls in this photograph. Airport Manager John Berry, former City Manager William Hopkins, NACA Assistant Secretary Ed Chamberlain, Langley Engineer-in-Charge Henry Reid, Executive Engineer Carlton Kemper, and Construction Manager Raymond Sharp are also present. The propeller building contained two torque stands to test complete engines at ambient conditions. The facility was primarily used at the time to study engine lubrication and cooling systems for World War II aircraft, which were required to perform at higher altitudes and longer ranges than previous generations.

Decoding Student Satisfaction: How to Manage and Improve the Laboratory Experience

ERIC Educational Resources Information Center

Nikolic, Sasha; Ritz, Christian; Vial, Peter James; Ros, Montserrat; Stirling, David

2015-01-01

The laboratory plays an important role in teaching engineering skills. An Electrical Engineering department at an Australian University implemented a reform to monitor and improve student satisfaction with the teaching laboratories. A Laboratory Manager was employed to oversee the quality of 27 courses containing instructional laboratories.…

An Analog Computer for Electronic Engineering Education

ERIC Educational Resources Information Center

Fitch, A. L.; Iu, H. H. C.; Lu, D. D. C.

2011-01-01

This paper describes a compact analog computer and proposes its use in electronic engineering teaching laboratories to develop student understanding of applications in analog electronics, electronic components, engineering mathematics, control engineering, safe laboratory and workshop practices, circuit construction, testing, and maintenance. The…

7. This photographic copy of an engineering drawing displays the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. This photographic copy of an engineering drawing displays the building's floor plan in its 1995 arrangement, with rooms designated. California Institute of Technology, Jet Propulsion Laboratory, Facilities Engineering and Construction Office, "Addition to Weigh & Control Bldg. E-35, Demolition, Floor and Roof Plans," drawing no. E35/3-0, October 5, 1983. California Institute of Technology, Jet Propulsion Laboratory, Plant Engineering: engineering drawings of structures at JPL Edwards Facility. Drawings on file at JPL Plant Engineering, Pasadena, California. - Jet Propulsion Laboratory Edwards Facility, Weigh & Control Building, Edwards Air Force Base, Boron, Kern County, CA

4. This photographic copy of an engineering drawing shows the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. This photographic copy of an engineering drawing shows the plan and details for Test Stand "G" and the placement of the vibrator. California Institute of Technology, Jet Propulsion Laboratory, Plant Engineering: "Vibration Test Facility-Bldg E-72, Floor & Roof Plans, Sections, Details & Door Schedule," drawing no. E72/2-5, 21 May 1964. California Institute of Technology, Jet Propulsion Laboratory, Plant Engineering: engineering drawings of structures at JPL Edwards Facility. Drawings on file at JPL Plant Engineering, Pasadena, California. - Jet Propulsion Laboratory Edwards Facility, Test Stand G, Edwards Air Force Base, Boron, Kern County, CA

Los Alamos National Laboratory Science Education Programs. Progress report, October 1, 1994--December 31, 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gill, D.H.

During the 1994 summer institute NTEP teachers worked in coordination with LANL and the Los Alamos Middle School and Mountain Elementary School to gain experience in communicating on-line, to gain further information from the Internet and in using electronic Bulletin Board Systems (BBSs) to exchange ideas with other teachers. To build on their telecommunications skills, NTEP teachers participated in the International Telecommunications In Education Conference (Tel*ED `94) at the Albuquerque Convention Center on November 11 & 12, 1994. They attended the multimedia keynote address, various workshops highlighting many aspects of educational telecommunications skills, and the Telecomm Rodeo sponsored by Losmore » Alamos National Laboratory. The Rodeo featured many presentations by Laboratory personnel and educational institutions on ways in which telecommunications technologies can be use din the classroom. Many were of the `hands-on` type, so that teachers were able to try out methods and equipment and evaluate their usefulness in their own schools and classrooms. Some of the presentations featured were the Geonet educational BBS system, the Supercomputing Challenge, and the Sunrise Project, all sponsored by LANL; the `CU-seeMe` live video software, various simulation software packages, networking help, and many other interesting and useful exhibits.« less

Annotated bibliography of software engineering laboratory literature

NASA Technical Reports Server (NTRS)

Kistler, David; Bristow, John; Smith, Don

1994-01-01

This document is an annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory. Nearly 200 publications are summarized. These publications cover many areas of software engineering and range from research reports to software documentation. This document has been updated and reorganized substantially since the original version (SEL-82-006, November 1982). All materials have been grouped into eight general subject areas for easy reference: (1) The Software Engineering Laboratory; (2) The Software Engineering Laboratory: Software Development Documents; (3) Software Tools; (4) Software Models; (5) Software Measurement; (6) Technology Evaluations; (7) Ada Technology; and (8) Data Collection. This document contains an index of these publications classified by individual author.

Technical Communications in Engineering and Science: The Practices within a Government Defense Laboratory.

ERIC Educational Resources Information Center

Von Seggern, Marilyn; Jourdain, Janet M.

1996-01-01

A survey of the different technical communications and information-related activities of 305 engineers and scientists from 3 sites of the Philips Laboratory, an Air Force research and development laboratory, found that scientists have a closer affinity for libraries and traditional information sources than do engineers. Eight tables depict survey…

E-Laboratory Design and Implementation for Enhanced Science, Technology and Engineering Education

ERIC Educational Resources Information Center

Morton, William; Uhomoibhi, James

2011-01-01

Purpose: This paper aims to report on the design and implementation of an e-laboratory for enhanced science, technology and engineering education studies. Design/methodology/approach: The paper assesses a computer-based e-laboratory, designed for new entrants to science, technology and engineering programmes of study in further and higher…

NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper 56: Technical Communications in Engineering and Science: The Practices Within a Government Defense Laboratory

NASA Technical Reports Server (NTRS)

VonSeggern, Marilyn; Jourdain, Janet M.; Pinelli, Thomas E.

1996-01-01

Research in recent decades has identified the varied information needs of engineers versus scientists. While most of that research looked at the differences among organizations, we surveyed engineers and scientists within a single Air Force research and development laboratory about their information gathering, usage, and production practices. The results of the Phillips Laboratory survey confirm prior assumptions about distinctions between engineering and science. Because military employees responded at a much higher rate than civilian staff, the survey also became an opportunity to profile a little-known segment of the engineer/scientist population. In addition to the effect Phillips Laboratory's stated mission may have on member engineers and scientists, other factors causing variations in technical communication and information-related activities are identified.

Health care providers' perspectives on a weekly text-messaging intervention to engage HIV-positive persons in care (WelTel BC1).

PubMed

Murray, Melanie C M; O'Shaughnessy, Sara; Smillie, Kirsten; Van Borek, Natasha; Graham, Rebecca; Maan, Evelyn J; van der Kop, Mia L; Friesen, Karen; Albert, Arianne; Levine, Sarah; Pick, Neora; Ogilvie, Gina; Money, Deborah; Lester, Richard

2015-10-01

Though evidence shows that Mobile health (mHealth) interventions can improve adherence and viral load in HIV-positive persons, few have studied the health care providers' (HCP) perspective. We conducted a prospective mixed methods pilot study using the WelTel intervention wherein HIV-positive participants (n = 25) received weekly interactive text messages for 6 months. Text message response rate and topic data were collected to illustrate the HCP experience. The aim of this study is to explore intervention acceptability and feasibility from the HCP perspective through a baseline focus group and end of study interviews with HCP impacted by the intervention. Interview data were thematically coded using the Technology Acceptance Model. HCPs identified that the WelTel intervention engaged patients in building relationships, while organizing and streamlining existing mHealth efforts and dealing with privacy issues. HCPs recognized that although workload would augment initially, intervention benefits were many, and went beyond simply improving HIV viral load.

Nonequilibrium transport of charge carriers and transient electroluminescence in organic light-emitting diodes

NASA Astrophysics Data System (ADS)

Nikitenko, V. R.; von Seggern, H.

2007-11-01

An analytic theory of nonequilibrium hopping charge transport in disordered organic materials includes quasiequilibrium (normal) and extremely nonequilibrium (dispersive) regimes as limiting cases at long and short times, respectively. In the intermediate interval of time quasiequilibrium value of mobility is nearly established while the coefficient of field-assisted diffusion continues to increase (quasidispersive regime). Therefore, normalized time dependencies of transient current in time-of-flight (TOF) conditions are practically independent of field strength and sample thickness, in good agreement both with data of TOF experiments for molecularly doped polymers and results of numerical simulations of Gaussian disorder model. An analytic model of transient electroluminescence (TEL) is developed on the base of the mentioned theory. Strong asymmetry of mobilities is presumed. In analogy with TOF transients, dispersion parameter of normalized TEL intensity is anomalously large and almost field independent in the quasidispersive regime of transport. The method for determination of mobility from TEL data is proposed.

"europe Towards the Stars"

NASA Astrophysics Data System (ADS)

1995-06-01

YOUNG EUROPEANS AND THEIR TEACHERS TO OBSERVE WITH SUPER-TELESCOPE With the above title, and following the very successful events of the past two years [1], ESO again organises an "educational adventure" in 1995. It takes place within the framework of the "Third European Week for Scientific and Technological Culture", initiated and supported by the European Commission. This time ESO will invite about fifty 17-18 year old grammar school pupils with their teachers to try their skills at one of the world's most advanced astronomical telescopes. The young people are the winners of a Europe-wide astronomy contest that will take place during the summer and early autumn. The main event involves a free, week-long stay at the Headquarters of the European Southern Observatory in November this year. During this time, the participants will experience modern astronomy and astrophysics at one of the world's foremost international centres and also have the opportunity to perform remote observations via a satellite link with two telescopes at the ESO La Silla observatory in Chile. THE CONTEST This year's programme will begin with national competitions in sixteen European countries. It is devised as a contest between joint teams of pupils and teachers. Each team is expected to consist of (up to) three pupils and their teacher. They can choose between four different subjects requiring either practical or theoretical work. Each subject has a strong scientific and technological component. Here are short descriptions: At the telescope - Catching and interpreting the signals. "You observe with an existing telescope and instrument of your own choice. In your observational report you describe the scientific goal, the capability of your equipment, the execution of the observation. You discuss the observational data including an error analysis, and describe the conclusions." Technology for Science - Building an Instrument. "You build an astronomical instrument (e.g. a photometer or a spectrograph, fitted with the associated detector). In the instrument documentation, you describe the instrument, its design, construction and the test results." A Future Space Mission - Designing an on-board Instrument. "You design an instrument for a future space mission to the outer Solar System. The purpose is to carry out observations of Pluto and Transneptunian Objects. Describe the design, the physical/chemical principles of the instrument and the observations to be made with it. Give examples of some possible results." Theory - Looking into the Future. "You describe a stable planetary system around another star. Your report contains a description of the conditions (inner structure, composition, surface features, atmosphere) of the planets. What are the technical requirements for observing this system from the Earth? Which kind of observations of these objects can be done with available instruments?" None of these subjects are easy to treat, but experience has shown that thanks to very dedicated teachers, the teaching of astronomy takes place at a surprisingly high level at many of Europe's schools. The establishment of the European Association for Astronomy Education (EAAE) last year has also resulted in a Europe-wide, increasing interest in these matters and many EAAE members actively promote the present contest and participate in the organisation. Many good entries are therefore expected. The participation is open to pupils in their last or second-to-last year before baccalaureate. In each country, a National Committee has been established that will organise the contest and evaluate the responses. In most cases, the closing date is early October 1995, and the national award ceremonies will take place in early November. Detailed information about this programme may be obtained from the National Committees at the addresses below. A VISIT TO ESO The members of the winning teams from each country will be invited to spend an exciting and informative week at the ESO Headquarters in Garching near Munich (Germany) in mid-November 1995. Here they will experience front-line science and partake in the daily life of one of Europe's foremost scientific establishments. Assisted by professional astronomers, they will prepare and carry out real astronomical observations with the 1.4-metre CAT (Coude Auxiliary Telescope) and the very advanced 3.5-metre NTT (New Technology Telescope) from ESO's remote control centre. They will also begin the treatment of the registered data and, if possible, arrive at tentative interpretations. The week will undoubtedly be very hectic, but it will of course also include events of a more social character which will further emphasize the pan-European nature of this unique visit. ESO will provide more details about this programme in early November 1995, including the planned media coverage. ADDRESSES OF THE NATIONAL COMMITTEES For further information about the programme "Europe Towards The Stars", please contact the National Committee in your country. Austria: Prof. H. Mucke, Astronomisches Buero, Hasenwartgasse 32, A-1138 Vienna, Tel. 0043-1-8893541 Belgium: Dr. C. Sterken, Vrije Universiteit Brussel, Campus Ofenplein, Pleinlaan 2, B-1050 Brussels, Tel. 0032-2-6293469, Fax 0032-9-3623976, E-mail csterken@is1.vub.ac.be Denmark: Mr. B. F. Joergensen, Tycho Brahe Planetariet, Gl. Kongevej 10, DK-1610 Copenhagen V, Tel. 0045-33-144888, Fax 0045-33-142888, E-mail tycho@inet.uni-c.dk Finland: Mr. M. Hotakainen, Tahtitieteellinen Yhdistys Ursa Ry, Laivanvarustajankatu 9C 54, FIN-00140 Helsinki, Tel. 00358-0-174048, Fax 00358-0-657728 France: Mr. B. Pellequer, Geospace d'Aniane, Boîte Postale 22, F-34150 Aniane, Tel. 0033-6-7034949, Fax 0033-6-7752864 Germany: Dr. K.-H. Lotze, Friedrich-Schiller-Universitaet, Max-Wien-Platz 1, D-07743 Jena, Germany, Tel. +49-3641-635904/636654, Fax +49-3641-636728 Greece: Dr. D. Simopoulos, Eugenides Foundation, Astronomy Department, 387 Sygrou Avenue, Palaio Faliro, GR-175 64 Athens, Tel. 0030-1-941-1181, Fax 0030-1-941-7372 Ireland: Dr I. Elliot, Dunsink Observatory (Dublin Institute for Advanced Studies), Castleknock, Dublin 15, Tel. 00353-1- 838-7911/7959, Fax 00353-1-8387090, E-mail ie@dunsink.dias.ie Italy: Prof. F. Pacini, Osservatorio Astrofisico di Arcetri, Largo Enrico Fermi 5, I-50125 Florence, Tel. 0039-55-2752246, Fax 0039-55-220039, E-mail pacini@arcetri.astro.it Luxemburg: Dr. F. Wagner, Laboratoire de Physique, Lycee de Garcons d'Esch, BP 195, L-4002 Esch/Alzette, Tel. 00352-556285, Fax 00352-570994 The Netherlands: Dr. H. Lamers, Rijksuniversiteit Utrecht, Princetonplein 5, Postbus 80.000, NL-3508 TA Utrecht, Tel. 0031-30-535200, Fax 0031-30531601, email hennyl@sron.ruu.nl Portugal: Dr. T. Lago, Centro de Astrofisico, Universidade do Porto, Rua do Campo Alegre 823, P-4150 Porto, Tel. 00351-2-6007081, Fax 00351-2-6007982, E-mail mtlago@ncc.up.pt Spain: Dr. Asuncion Sanchez/Dr Telmo Fernandez, Planetario de Madrid, Parque Tierno Galvan, E-28045 Madrid, Tel. 0034-1-4673578, Fax 0034-1-4681154, E-mail tfc@vilspa.esa.es Sweden: Dr. Kerstin Loden, Stockholms Observatorium, S-133 36 Saltsjoebaden, Tel. 0046-8-164454, Fax 0046-8-7174719, e-mail lodenk@astro.su.se Switzerland: Mr. M. Wieland, Schweizer Jugend Forscht/La Science Appelle les Jeunes, Technoramastrasse 1, CH-8404 Winterthur, Tel. 0041-52-2424440, Fax 0041-52-2422967 United Kingdom: Dr A. M. Cohen, Dane Valley High School, Jackson Road, Congleton, Cheshire CW12 1NT, England, United Kingdom, Tel. +44-260-273000, Fax +44-260-297352 (until July 1, 1995). The National Committee for the United Kingdom, c/o The Association for Astronomy Education, 9 Hurst Lane, Bollington, Macclesfield, Cheshire SK10 5LN, England (after July 1, 1995). [1] See ESO Press Releases 08/93 of 5 November 1993 and 17/94 of 2 December 1994. ESO Press Information is made available on the World-Wide Web (URL: http://www.hq.eso.org/) and on CompuServe (space science and astronomy area, GO SPACE).

Analyzing the Function of Cartilage Replacements: A Laboratory Activity to Teach High School Students Chemical and Tissue Engineering Concepts

ERIC Educational Resources Information Center

Renner, Julie N.; Emady, Heather N.; Galas, Richards J., Jr.; Zhange, Rong; Baertsch, Chelsey D.; Liu, Julie C.

2013-01-01

A cartilage tissue engineering laboratory activity was developed as part of the Exciting Discoveries for Girls in Engineering (EDGE) Summer Camp sponsored by the Women In Engineering Program (WIEP) at Purdue University. Our goal was to increase awareness of chemical engineering and tissue engineering in female high school students through a…

University of Illinois at Urbana-Champaign, Materials Research Laboratory progress report for FY 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-07-01

This interdisciplinary laboratory in the College of Engineering support research in areas of condensed matter physics, solid state chemistry, and materials science. These research programs are developed with the assistance of faculty, students, and research associates in the departments of Physics, Materials Science and Engineering, chemistry, Chemical Engineering, Electrical Engineering, Mechanical Engineering, and Nuclear Engineering.

Problem-based learning biotechnology courses in chemical engineering.

PubMed

Glatz, Charles E; Gonzalez, Ramon; Huba, Mary E; Mallapragada, Surya K; Narasimhan, Balaji; Reilly, Peter J; Saunders, Kevin P; Shanks, Jacqueline V

2006-01-01

We have developed a series of upper undergraduate/graduate lecture and laboratory courses on biotechnological topics to supplement existing biochemical engineering, bioseparations, and biomedical engineering lecture courses. The laboratory courses are based on problem-based learning techniques, featuring two- and three-person teams, journaling, and performance rubrics for guidance and assessment. Participants initially have found them to be difficult, since they had little experience with problem-based learning. To increase enrollment, we are combining the laboratory courses into 2-credit groupings and allowing students to substitute one of them for the second of our 2-credit chemical engineering unit operations laboratory courses.

Intelligent Performance Assessment of Students' Laboratory Work in a Virtual Electronic Laboratory Environment

ERIC Educational Resources Information Center

Achumba, I. E.; Azzi, D.; Dunn, V. L.; Chukwudebe, G. A.

2013-01-01

Laboratory work is critical in undergraduate engineering courses. It is used to integrate theory and practice. This demands that laboratory activities are synchronized with lectures to maximize their derivable learning outcomes, which are measurable through assessment. The typical high costs of the traditional engineering laboratory, which often…

Perceptions and Impact of Mandatory eLearning for Foundation Trainee Doctors: A Qualitative Evaluation.

PubMed

Brooks, Hannah L; Pontefract, Sarah K; Vallance, Hannah K; Hirsch, Christine A; Hughes, Elizabeth; Ferner, Robin E; Marriott, John F; Coleman, Jamie J

2016-01-01

Junior doctors in the UK must complete various educational components during their two year Foundation training programme. It is important that mandatory learning is informative and engaging. The aim of this study was to evaluate trainee doctors' perceptions of a Technology Enhanced Learning (TEL) programme developed to improve prescribing competency. Focus groups and interviews were conducted at three hospital sites in the West Midlands. Codes, sub-themes and themes were determined using deductive and inductive thematic analysis. Data were collected from 38 Foundation trainee doctors. Results revealed major themes relating to prescribing education, the user experience and user engagement. Key findings included the positive impact of preparedness following undergraduate education on the user experience of the TEL programme at the postgraduate level; the impact of content, structure, and individual learning needs and styles on the user experience; and the impact of motivation and time on engagement. Most trainees engaged with the programme owing to its mandatory nature; however, some trainees also used the programme voluntarily, for example, to acquire knowledge prior to starting a new placement. It is important to ensure that learners are willing to engage with mandatory TEL, and that they have the time and motivation to do so. It is also important to ensure that learners have a positive user experience and that in designing TEL individual differences in learning styles and needs are taken into account. These findings have implications for educators and system developers in the construction and design of mandatory eLearning programmes.

[The beginnings of orthopedic surgery in Israel].

PubMed

Tauber, Chanan

2013-08-01

In early mandatory Israel, orthopedics was mainly conservative, The first modern orthopedic surgeon was Ernst Spira from Czechoslovakia who established an orthopedic service at the Beilinson Hospital in Petah Tikva and left in 1948 to establish the Orthopedic Department and the Rehabilitation Center in Tel Hashomer, which treated the War of Independence casualties including amputees and victims of spinal cord injuries. A second orthopedic department was opened in Tel Hashomer by Shmuel Weissman who left in 1961 to open the Orthopedic Department at the Ichilov hospital in Tel Aviv. Shmuel Weissman became the first Chairman of Orthopedic Surgery at the Tel Aviv University medical school. In 1955, Myer Makin opened a modern orthopedic department in the Hadassah Hospital in Jerusalem and the Alyn Hospital for crippled children. In 1951, Assaf Harofeh Hospital opened the Department of Orthopedic Surgery headed by Anatol Axer who specialized in the treatment and rehabilitation of polio patients. The majority of the second generation of orthopedic department directors was trained by these four surgeons. Major developments in the 1960s and 1970s were the introduction of the AO system revolutionizing fracture treatment from conservative to operative treatment, the advent of total hip and knee replacements, Harrington instrumentation in spinal surgery and arthroscopy were major advances in orthopedic patient care brought to Israel by the aforementioned second generation of orthopedic surgeons. Hand surgery became an independent subspecialty of orthopedics and was lead by the internationally renowned hand surgeon, Isidore Kessler.

Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance.

PubMed

Khair, Lyne; Chang, Ya-Ting; Subramanian, Lakxmi; Russell, Paul; Nakamura, Toru M

2010-06-01

While telomeres must provide mechanisms to prevent DNA repair and DNA damage checkpoint factors from fusing chromosome ends and causing permanent cell cycle arrest, these factors associate with functional telomeres and play critical roles in the maintenance of telomeres. Previous studies have established that Tel1 (ATM) and Rad3 (ATR) kinases play redundant but essential roles for telomere maintenance in fission yeast. In addition, the Rad9-Rad1-Hus1 (911) and Rad17-RFC complexes work downstream of Rad3 (ATR) in fission yeast telomere maintenance. Here, we investigated how 911, Rad17-RFC and another RFC-like complex Ctf18-RFC contribute to telomere maintenance in fission yeast cells lacking Tel1 and carrying a novel hypomorphic allele of rad3 (DBD-rad3), generated by the fusion between the DNA binding domain (DBD) of the fission yeast telomere capping protein Pot1 and Rad3. Our investigations have uncovered a surprising redundancy for Rad9 and Hus1 in allowing Rad1 to contribute to telomere maintenance in DBD-rad3 tel1 cells. In addition, we found that Rad17-RFC and Ctf18-RFC carry out redundant telomere maintenance functions in DBD-rad3 tel1 cells. Since checkpoint sensor proteins are highly conserved, genetic redundancies uncovered here may be relevant to telomere maintenance and detection of DNA damage in other eukaryotes.

Roles of the Checkpoint Sensor Clamp Rad9-Rad1-Hus1 (911)-Complex and the Clamp Loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe Telomere Maintenance

PubMed Central

Khair, Lyne; Chang, Ya-Ting; Subramanian, Lakxmi; Russell, Paul; Nakamura, Toru M.

2011-01-01

While telomeres must provide mechanisms to prevent DNA repair and DNA damage checkpoint factors from fusing chromosome ends and causing permanent cell cycle arrest, these factors associate with functional telomeres and play critical roles in the maintenance of telomeres. Previous studies have established that Tel1 (ATM) and Rad3 (ATR) kinases play redundant but essential roles for telomere maintenance in fission yeast. In addition, the Rad9-Rad1-Hus1 (911) and Rad17-RFC complexes work downstream of Rad3 (ATR) in fission yeast telomere maintenance. Here, we investigated how 911, Rad17-RFC and another RFC-like complex Ctf18-RFC contribute to telomere maintenance in fission yeast cells lacking Tel1 and carrying a novel hypomorphic allele of rad3 (DBD-rad3), generated by the fusion between the DNA binding domain (DBD) of the fission yeast telomere capping protein Pot1 and Rad3. Our investigations have uncovered a surprising redundancy for Rad9 and Hus1 in allowing Rad1 to contribute to telomere maintenance in DBD-rad3 tel1Δ cells. In addition, we found that Rad17-RFC and Ctf18-RFC carry out redundant telomere maintenance functions in DBD-rad3 tel1Δ cells. Since checkpoint sensor proteins are highly conserved, genetic redundancies uncovered here may be relevant to telomere maintenance and detection of DNA damage in other eukaryotes. PMID:20505337

A block randomized controlled trial of a brief smoking cessation counselling and advice through short message service on participants who joined the Quit to Win Contest in Hong Kong.

PubMed

Chan, Sophia S C; Wong, David C N; Cheung, Yee Tak Derek; Leung, Doris Y P; Lau, Lisa; Lai, Vienna; Lam, Tai-Hing

2015-08-01

The present trial examined the effectiveness of brief interventions for smokers who joined the Hong Kong Quit to Win Contest to quit smoking. A block randomized controlled trial allocated 1003 adult daily smokers to three groups: (i) The TEL group (n = 338) received a 5-min nurse-led telephone counselling; (ii) The SMS group (n = 335) received eight text messages through mobile phone and (iii) The CONTROL group (n = 330) did not receive the above interventions. Participants with biochemically verified abstinence at 6-month follow-up could receive cash incentive. The primary outcome was the self-reported 7-day point prevalence (PP) of tobacco abstinence at 6-month follow-up. The abstinence rate in the TEL, SMS and CONTROL group was 22.2, 20.6 and 20.3%, respectively (P for TEL versus CONTROL = 0.32; P for SMS versus CONTROL = 0.40). When abstinence at 2-, 6- and 12-month follow-up was modelled simultaneously, the TEL group had a higher abstinence than the CONTROL group (Adjusted OR = 1.38, 95% CI = 1.01-1.88, P = 0 .04). In the Quit to Win Contest, the brief telephone counselling might have increased abstinence, but the text messages had no significant effect. Further studies on intensive intervention and interactive messaging services are warranted. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

32 CFR 555.2 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-07-01

... FOR OTHERS § 555.2 Applicability. This regulation applies to the U.S. Army Engineer Waterways Experiment Station (WES), the U.S. Army Construction Engineering Research Laboratory (CERL), the U.S. Army Engineer Topographic Laboratories (ETL), the U.S. Army Coastal Engineering Research Center (CERC), the U.S...

32 CFR 555.2 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-07-01

... FOR OTHERS § 555.2 Applicability. This regulation applies to the U.S. Army Engineer Waterways Experiment Station (WES), the U.S. Army Construction Engineering Research Laboratory (CERL), the U.S. Army Engineer Topographic Laboratories (ETL), the U.S. Army Coastal Engineering Research Center (CERC), the U.S...

32 CFR 555.2 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... FOR OTHERS § 555.2 Applicability. This regulation applies to the U.S. Army Engineer Waterways Experiment Station (WES), the U.S. Army Construction Engineering Research Laboratory (CERL), the U.S. Army Engineer Topographic Laboratories (ETL), the U.S. Army Coastal Engineering Research Center (CERC), the U.S...

32 CFR 555.2 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-07-01

... FOR OTHERS § 555.2 Applicability. This regulation applies to the U.S. Army Engineer Waterways Experiment Station (WES), the U.S. Army Construction Engineering Research Laboratory (CERL), the U.S. Army Engineer Topographic Laboratories (ETL), the U.S. Army Coastal Engineering Research Center (CERC), the U.S...

This photocopy of an engineering drawing shows the BakerPerkins 150gallon ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

This photocopy of an engineering drawing shows the Baker-Perkins 150-gallon mixer installation in the building. Austin, Field & Fry, Architects Engineers, 22311 West Third Street, Los Angeles 57, California: Edwards Test Station Complex, Jet Propulsion Laboratory, California Institute of Technology, Edwards Air Force Base, Edwards, California: "150 Gallon Mixer System Bldg. E-34, Plans, Sections & Details," drawing no. E34/6-0, 10 July 1963. California Institute of Technology, Jet Propulsion Laboratory, Plant Engineering: engineering drawings of structures at JPL Edwards Facility. Drawings on file at JPL Plant Engineering, Pasadena, California - Jet Propulsion Laboratory Edwards Facility, Mixer, Edwards Air Force Base, Boron, Kern County, CA

This photographic copy of an engineering drawing shows floor plans, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

This photographic copy of an engineering drawing shows floor plans, sections and elevations of Building E-86, with details typical of the steel frame and "Transite" building construction at JPL Edwards Facility. California Institute of Technology, Jet Propulsion Laboratory, Facilities Engineering and Construction Office: "Casting & Curing, Building E-86, Floor Plan, Elevations & Section," drawing no. E86/6, 25 February 1977. California Institute of Technology, Jet Propulsion Laboratory, Plant Engineering: engineering drawings of structures at JPL Edwards Facility. Drawings on file at JPL Plant Engineering, Pasadena, California - Jet Propulsion Laboratory Edwards Facility, Casting & Curing Building, Edwards Air Force Base, Boron, Kern County, CA

A woman like you: Women scientists and engineers at Brookhaven National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benkovitz, Carmen; Bernholc, Nicole; Cohen, Anita

1991-01-01

This publication by the women in Science and Engineering introduces career possibilities in science and engineering. It introduces what work and home life are like for women who have already entered these fields. Women at Brookhaven National Laboratory work in a variety of challenging research roles -- from biologist and environmental scientist to safety engineer, from patent lawyer to technician. Brookhaven National Laboratory is a multi-program laboratory which carries out basic and applied research in the physical, biomedical and environmental sciences and in selected energy technologies. The Laboratory is managed by Associated University, Inc., under contract with the US Departmentmore » of Energy. Brookhaven and the other national laboratories, because of their enormous research resources, can play a critical role in a education and training of the workforce.« less

A woman like you: Women scientists and engineers at Brookhaven National Laboratory. Careers in action

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-12-31

This publication by the women in Science and Engineering introduces career possibilities in science and engineering. It introduces what work and home life are like for women who have already entered these fields. Women at Brookhaven National Laboratory work in a variety of challenging research roles -- from biologist and environmental scientist to safety engineer, from patent lawyer to technician. Brookhaven National Laboratory is a multi-program laboratory which carries out basic and applied research in the physical, biomedical and environmental sciences and in selected energy technologies. The Laboratory is managed by Associated University, Inc., under contract with the US Departmentmore » of Energy. Brookhaven and the other national laboratories, because of their enormous research resources, can play a critical role in a education and training of the workforce.« less

FY10 Engineering Innovations, Research and Technology Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lane, M A; Aceves, S M; Paulson, C N

This report summarizes key research, development, and technology advancements in Lawrence Livermore National Laboratory's Engineering Directorate for FY2010. These efforts exemplify Engineering's nearly 60-year history of developing and applying the technology innovations needed for the Laboratory's national security missions, and embody Engineering's mission to ''Enable program success today and ensure the Laboratory's vitality tomorrow.'' Leading off the report is a section featuring compelling engineering innovations. These innovations range from advanced hydrogen storage that enables clean vehicles, to new nuclear material detection technologies, to a landmine detection system using ultra-wideband ground-penetrating radar. Many have been recognized with R&D Magazine's prestigious R&Dmore » 100 Award; all are examples of the forward-looking application of innovative engineering to pressing national problems and challenging customer requirements. Engineering's capability development strategy includes both fundamental research and technology development. Engineering research creates the competencies of the future where discovery-class groundwork is required. Our technology development (or reduction to practice) efforts enable many of the research breakthroughs across the Laboratory to translate from the world of basic research to the national security missions of the Laboratory. This portfolio approach produces new and advanced technological capabilities, and is a unique component of the value proposition of the Lawrence Livermore Laboratory. The balance of the report highlights this work in research and technology, organized into thematic technical areas: Computational Engineering; Micro/Nano-Devices and Structures; Measurement Technologies; Engineering Systems for Knowledge Discovery; and Energy Manipulation. Our investments in these areas serve not only known programmatic requirements of today and tomorrow, but also anticipate the breakthrough engineering innovations that will be needed in the future.« less

CUBE (Computer Use By Engineers) symposium abstracts. [LASL, October 4--6, 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruminer, J.J.

1978-07-01

This report presents the abstracts for the CUBE (Computer Use by Engineers) Symposium, October 4, through 6, 1978. Contributors are from Lawrence Livermore Laboratory, Los Alamos Scientific Laboratory, and Sandia Laboratories.

Seroprevalence of Antibodies against Human Herpesvirus 8 in a Population of Renal Transplant Recipients at Hôtel-Dieu de Québec Hospital

PubMed Central

Delorme, S.; Houde, I.; Deschênes, L.

2003-01-01

We conducted a seroepidemiologic study to determine the prevalence of anti-human herpesvirus 8 antibodies in a renal transplant population at Hôtel-Dieu de Québec Hospital. Testing for immunoglobulin G antibodies against lytic and latent antigens was performed on serum samples from 150 renal transplant patients. Human immunodeficiency virus-positive patients with confirmed Kaposi's sarcoma were used as positive controls. None of the renal transplant patients tested positive. PMID:14605164

eLearning or technology enhanced learning in medical education-Hope, not hype.

PubMed

Goh, Poh Sun

2016-09-01

This Personal View elaborates on my strong conviction that the excitement and positive feelings that many of us have for eLearning or Technology enhanced learning (TeL) is well founded, and will argue why our hopes are justified, and not misplaced. In a nutshell, I believe that eLearning or TeL is a significant advance from previous generations of educational innovation, and offers benefits for students, educators and administrators; by synergistically combining the capabilities of digital content, the Internet, and mobile technology, supported by software and applications or "Apps".

Size Distribution, Chemical Composition and Optical Properties of Atmospheric Dust in Israel: A Comparison of Urban and Desert Aerosols under Clear and Dusty Conditions.

DTIC Science & Technology

1980-02-01

size distribution and aerosol particle concentrations during a winter period in Mitzpe Ramon. Negev desert. Fig. 5 Comparison of normalized frequency...Israel. The upper two samples are from Mitzpe Ramon in the Negev desert. The bottom three are from Tel Aviv. The lighter of the three Tel Aviv samples (the...shown show much higher imaginary indices than do those from the Negev desert or the two American desert localities (Lindberg et al., 1976). Fig. 12

Adaptability in Coalition Teamwork: Leader and Team Adaptability in Multi-National Coalitions (LTAMC) (Adaptabilite dans le travail d’equipe en Coalition: Adaptabilite des chefs et des equipes dans les coalitions multinationales)

DTIC Science & Technology

2012-11-01

Bldg. 33 Wright- Patterson AFB, OH 45433 Email: janet.sutton@wpafb.af.mil xviii RTO-TR-HFM-138 RTO-TR-HFM-138 ES - 1 Adaptability in...711 Human Performance Wing/Human Effectiveness, Cognitive Systems Branch Wright- Patterson AFB, OH 45433 USA Tel: 1+ 937.656.4316 Fax: 1...AFRL) 711 Human Performance Wing/Human Effectiveness, Cognitive Systems Branch Wright- Patterson AFB, OH 45433 USA Tel: 1+ 937.785.3165 Fax: 1

Engineering Laboratory Instruction in Virtual Environment--"eLIVE"

ERIC Educational Resources Information Center

Chaturvedi, Sushil; Prabhakaran, Ramamurthy; Yoon, Jaewan; Abdel-Salam, Tarek

2011-01-01

A novel application of web-based virtual laboratories to prepare students for physical experiments is explored in some detail. The pedagogy of supplementing physical laboratory with web-based virtual laboratories is implemented by developing a web-based tool, designated in this work as "eLIVE", an acronym for Engineering Laboratory…

United States Air Force Summer Research Program -- 1993 Summer Research Program Final Reports. Volume 10. Wright Laboratory

DTIC Science & Technology

1993-01-01

LABORATORIES 5800 Uplander Way Culver City, CA 90230-6608 Program Director, RDL Program Manager , AFOSR Gary Moore Col. Hal Rhoades Program Manager , RDL...Laboratory: PL/RK Aerospace Engineering University of Cinc nati Vol-Page No: 8-10 Cincinnati, OH 45221-0000 Burns, Paul Field: Electrical Engineering as...Laboratory: PL/GP Electrical Engineering Boston University Vol-Page No: a- 5 Boston, MA 2215-0000 GSRP Participant Data Stauffer, Joseph Field: Management MS

Proceedings of the Seventeenth Annual Software Engineering Workshop

NASA Technical Reports Server (NTRS)

1992-01-01

Proceedings of the Seventeenth Annual Software Engineering Workshop are presented. The software Engineering Laboratory (SEL) is an organization sponsored by NASA/Goddard Space Flight Center and created to investigate the effectiveness of software engineering technologies when applied to the development of applications software. Topics covered include: the Software Engineering Laboratory; process measurement; software reuse; software quality; lessons learned; and is Ada dying.

Linear- and Repetitive-Feature Detection Within Remotely Sensed Imagery

DTIC Science & Technology

2017-04-01

public release; distribution is unlimited. The U.S. Army Engineer Research and Development Center (ERDC) solves the nation’s toughest...Imagery Brendan West U.S. Army Engineer Research and Development Center (ERDC) Cold Regions Research and Engineering Laboratory (CRREL) 72 Lyme Road...and Intelligence System (ARTEMIS) U.S. Army Engineer Research and Development Center (ERDC) Cold Regions Research and Engineering Laboratory (CRREL

Engineering Institute

Science.gov Websites

Search Site submit National Security Education Center Los Alamos National LaboratoryEngineering Institute Addressing national needs by fostering specialized recruiting and strategic partnerships Los Alamos National LaboratoryEngineering Institute Menu NSEC Educational Programs Los Alamos Dynamics Summer

FY08 Engineering Research and Technology Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Minichino, C; McNichols, D

2009-02-24

This report summarizes the core research, development, and technology accomplishments in Lawrence Livermore National Laboratory's Engineering Directorate for FY2008. These efforts exemplify Engineering's more than 50-year history of developing and applying the technologies needed to support the Laboratory's national security missions. A partner in every major program and project at the Laboratory throughout its existence, Engineering has prepared for this role with a skilled workforce and technical resources developed through both internal and external venues. These accomplishments embody Engineering's mission: 'Enable program success today and ensure the Laboratory's vitality tomorrow.' Engineering's mission is carried out through basic research and technologymore » development. Research is the vehicle for creating competencies that are cutting-edge, or require discovery-class groundwork to be fully understood. Our technology efforts are discipline-oriented, preparing research breakthroughs for broader application to a variety of Laboratory needs. The term commonly used for technology-based projects is 'reduction to practice.' As we pursue this two-pronged approach, an enormous range of technological capabilities result. This report combines our work in research and technology into one volume, organized into thematic technical areas: Engineering Modeling and Simulation; Measurement Technologies; Micro/Nano-Devices and Structures; Engineering Systems for Knowledge and Inference; and Energy Manipulation. Our investments in these areas serve not only known programmatic requirements of today and tomorrow, but also anticipate the breakthrough engineering innovations that will be needed in the future.« less

POLLUTION PREVENTION RESEARCH ONGOING - EPA'S RISK REDUCTION ENGINEERING LABORATORY

EPA Science Inventory

The mission of the Risk Reduction Engineering Laboratory is to advance the understanding, development and application of engineering solutions for the prevention or reduction of risks from environmental contamination. This mission is accomplished through basic and applied researc...

Distance Learning and Skill Acquisition in Engineering Sciences: Present State and Prospects

ERIC Educational Resources Information Center

Potkonjak, Veljko; Jovanovic, Kosta; Holland, Owen; Uhomoibhi, James

2013-01-01

Purpose: The purpose of this paper is to present an improved concept of software-based laboratory exercises, namely a Virtual Laboratory for Engineering Sciences (VLES). Design/methodology/approach: The implementation of distance learning and e-learning in engineering sciences (such as Mechanical and Electrical Engineering) is still far behind…

FY04 Engineering Technology Reports Laboratory Directed Research and Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sharpe, R M

2005-01-27

This report summarizes the science and technology research and development efforts in Lawrence Livermore National Laboratory's Engineering Directorate for FY2004, and exemplifies Engineering's more than 50-year history of developing the technologies needed to support the Laboratory's missions. Engineering has been a partner in every major program and project at the Laboratory throughout its existence and has prepared for this role with a skilled workforce and the technical resources developed through venues like the Laboratory Directed Research and Development Program (LDRD). This accomplishment is well summarized by Engineering's mission: ''Enable program success today and ensure the Laboratory's vitality tomorrow''. Engineering's investmentmore » in technologies is carried out through two programs, the ''Tech Base'' program and the LDRD program. LDRD is the vehicle for creating those technologies and competencies that are cutting edge. These require a significant level of research or contain some unknown that needs to be fully understood. Tech Base is used to apply technologies to a Laboratory need. The term commonly used for Tech Base projects is ''reduction to practice''. Therefore, the LDRD report covered here has a strong research emphasis. Areas that are presented all fall into those needed to accomplish our mission. For FY2004, Engineering's LDRD projects were focused on mesoscale target fabrication and characterization, development of engineering computational capability, material studies and modeling, remote sensing and communications, and microtechnology and nanotechnology for national security applications. Engineering's five Centers, in partnership with the Division Leaders and Department Heads, are responsible for guiding the long-term science and technology investments for the Directorate. The Centers represent technologies that have been identified as critical for the present and future work of the Laboratory, and are chartered to develop their respective areas. Their LDRD projects are the key resources to attain this competency, and, as such, nearly all of Engineering's portfolio falls under one of the five Centers. The Centers and their Directors are: (1) Center for Computational Engineering: Robert M. Sharpe; (2) Center for Microtechnology and Nanotechnology: Raymond P. Mariella, Jr.; (3) Center for Nondestructive Characterization: Harry E. Martz, Jr.; (4) Center for Precision Engineering: Keith Carlisle; and (5) Center for Complex Distributed Systems: Gregory J. Suski, Acting Director.« less

Case Studies in Sustainability Used in an Introductory Laboratory Course to Enhance Laboratory Instruction

ERIC Educational Resources Information Center

Luster-Teasley, Stephanie; Hargrove-Leak, Sirena; Gibson, Willietta; Leak, Roland

2017-01-01

This educational research seeks to develop novel laboratory modules by using Case Studies in the Science Teaching method to introduce sustainability and environmental engineering laboratory concepts to 21st century learners. The increased interest in "going green" has led to a surge in the number of engineering students studying…

Perceptions and Impact of Mandatory eLearning for Foundation Trainee Doctors: A Qualitative Evaluation

PubMed Central

Brooks, Hannah L.; Vallance, Hannah K.; Hirsch, Christine A.; Hughes, Elizabeth; Ferner, Robin E.; Marriott, John F.; Coleman, Jamie J.

2016-01-01

Background Junior doctors in the UK must complete various educational components during their two year Foundation training programme. It is important that mandatory learning is informative and engaging. The aim of this study was to evaluate trainee doctors’ perceptions of a Technology Enhanced Learning (TEL) programme developed to improve prescribing competency. Method Focus groups and interviews were conducted at three hospital sites in the West Midlands. Codes, sub-themes and themes were determined using deductive and inductive thematic analysis. Results Data were collected from 38 Foundation trainee doctors. Results revealed major themes relating to prescribing education, the user experience and user engagement. Key findings included the positive impact of preparedness following undergraduate education on the user experience of the TEL programme at the postgraduate level; the impact of content, structure, and individual learning needs and styles on the user experience; and the impact of motivation and time on engagement. Most trainees engaged with the programme owing to its mandatory nature; however, some trainees also used the programme voluntarily, for example, to acquire knowledge prior to starting a new placement. Conclusions It is important to ensure that learners are willing to engage with mandatory TEL, and that they have the time and motivation to do so. It is also important to ensure that learners have a positive user experience and that in designing TEL individual differences in learning styles and needs are taken into account. These findings have implications for educators and system developers in the construction and design of mandatory eLearning programmes. PMID:28005938

Genetic evaluation of childhood acute lymphoblastic leukemia in Iraq using FTA cards.

PubMed

Al-Kzayer, Lika'a Fasih Y; Sakashita, Kazuo; Matsuda, Kazuyuki; Al-Hadad, Salma Abbas; Al-Jadiry, Mazin Faisal; Abed, Wisam Majeed; Abdulkadhim, Jaafar M H; Al-Shujairi, Tariq Abadi; Hasan, Janan Ghalib; Al-Abdullah, Hussam M Salih; Al-Ani, Mouroge H; Saber, Paiman Ali I; Inoshita, Toshi; Kamata, Minoru; Koike, Kenichi

2012-09-01

Genetic examination of childhood leukemia has not been available in Iraq. We here report the frequency of TEL-AML1, E2A-PBX1, MLL-AF4, and BCR-ABL chimeric transcripts in 264 Iraqi children newly diagnosed with acute lymphoblastic leukemia (ALL), using FTA cards impregnated with bone marrow aspirate or whole blood. The diagnosis of ALL was made according to standard French-American-British morphologic criteria. Based on the results of storage temperature and duration, most of the FTA samples were preserved at 4°C for up to 6 weeks in five Iraqi hospitals and then transferred to Japan for molecular analysis. Nested reverse transcription-polymerase chain reaction was adopted for the analysis. TEL-AML1 chimeric transcript product was found in 32 (12.1%) of 264 ALL patients. Eleven (4.2%) patients, 4 (1.5%) patients, and 11 (4.2%) patients had E2A-PBX1 mRNA, MLL-AF4 mRNA, and BCR-ABL mRNA, respectively. One patient had both TEL-AML1 and E2A-PBX1 fusion genes. The incidence of TEL-AML1 in Iraqi ALL children appears to be similar to or slightly higher than those of Jordan (12%) and Kuwait (7%). The prevalence and clinical findings of ALL patients with either E2A-PBX1 or BCR-ABL were comparable to the data reported elsewhere. International collaboration via FTA cards may be helpful to improve diagnosis and management of patients with hematological malignancies in low-income and underdeveloped countries. Copyright © 2012 Wiley Periodicals, Inc.

Mobile health for early retention in HIV care: a qualitative study in Kenya (WelTel Retain)

PubMed Central

Smillie, Kirsten; Van Borek, Natasha; van der Kop, Mia L; Lukhwaro, Abigael; Li, Neville; Karanja, Sarah; Patel, Anik R; Ojakaa, David; Lester, Richard T

2017-01-01

Many people newly diagnosed with HIV are lost to follow-up before timely initiation of antiretroviral therapy (ART). A randomised controlled trial (RCT), WelTel Kenya1, demonstrated the effectiveness of the WelTel text messaging intervention to improve clinical outcomes among patients initiating ART. In preparation for WelTel Retain, an RCT that will evaluate the effect of the intervention to retain patients in care immediately following HIV diagnosis, we conducted an informative qualitative study with people living with HIV (n = 15) and healthcare providers (HCP) (n = 5) in October 2012. Study objectives included exploring the experiences of people living with HIV who have attempted to engage in HIV care, the use of cell phones in everyday life, and perceptions of communicating via text message with HCP. Participants were recruited through convenience sampling. Semi-structured, qualitative interviews were conducted and recorded, transcribed verbatim and analysed using NVivo software. Analysis was guided by the Theory of Reasoned Action and the Technology Acceptance Model. Results indicate that while individuals have many motivators for engaging in care after diagnosis, structural and individual barriers including poverty, depression and fear of stigma prevent them from doing so. All participants had access to a mobile phone, and most were comfortable communicating through text messages, or were willing to learn. Both people living with HIV and HCP felt that increased communication via the text messaging intervention has the potential to enable early identification of problems, leading to timely problem solving that may improve retention and engagement in care during the first year after diagnosis. PMID:25555099

Mobile health for early retention in HIV care: a qualitative study in Kenya (WelTel Retain).

PubMed

Smillie, Kirsten; Van Borek, Natasha; van der Kop, Mia L; Lukhwaro, Abigael; Li, Neville; Karanja, Sarah; Patel, Anik R; Ojakaa, David; Lester, Richard T

2014-01-01

Many people newly diagnosed with HIV are lost to follow-up before timely initiation of antiretroviral therapy (ART). A randomised controlled trial (RCT), WelTel Kenya1, demonstrated the effectiveness of the WelTel text messaging intervention to improve clinical outcomes among patients initiating ART. In preparation for WelTel Retain, an RCT that will evaluate the effect of the intervention to retain patients in care immediately following HIV diagnosis, we conducted an informative qualitative study with people living with HIV (n = 15) and healthcare providers (HCP) (n = 5) in October 2012. Study objectives included exploring the experiences of people living with HIV who have attempted to engage in HIV care, the use of cell phones in everyday life, and perceptions of communicating via text message with HCP. Participants were recruited through convenience sampling. Semi-structured, qualitative interviews were conducted and recorded, transcribed verbatim and analysed using NVivo software. Analysis was guided by the Theory of Reasoned Action and the Technology Acceptance Model. Results indicate that while individuals have many motivators for engaging in care after diagnosis, structural and individual barriers including poverty, depression and fear of stigma prevent them from doing so. All participants had access to a mobile phone, and most were comfortable communicating through text messages, or were willing to learn. Both people living with HIV and HCP felt that increased communication via the text messaging intervention has the potential to enable early identification of problems, leading to timely problem solving that may improve retention and engagement in care during the first year after diagnosis.

Rearrangement of Upstream Sequences of the hTERT Gene During Cellular Immortalization

PubMed Central

Zhao, Yuanjun; Wang, Shuwen; Popova, Evgenya Y.; Grigoryev, Sergei A.; Zhu, Jiyue

2010-01-01

Telomerase expression, resulting from transcriptional activation of the hTERT gene, allows cells to acquire indefinite proliferative potential during cellular immortalization and tumorigenesis. However, mechanisms of hTERT gene activation in many immortal cell lines and cancer cells are poorly understood. Here, we report our studies on hTERT activation using genetically related pairs of telomerase-negative (Tel−) and -positive (Tel+) fibroblast lines. First, whereas transiently transfected plasmid reporters did not recapitulate the endogenous hTERT promoter, the promoter in chromosomally integrated bacterial artificial chromosome (BAC) reporters was activated in a subset of Tel+ cells, indicating that activation of the hTERT promoter required native chromatin context and/or distal regulatory elements. Second, the hTERT gene, located near the telomere of chromosome 5p, was translocated in all three Tel+ cell lines but not in their parental pre-crisis cells and Tel− immortal siblings. The breakage points were mapped to regions upstream of the hTERT promoter, indicating that the hTERT gene was the target of these chromosomal rearrangements. In two Tel+ cell lines, translocation of the endogenous hTERT gene appeared to be the major mechanism of its activation as the activity of hTERT promoter in many chromosomally integrated BAC reporters, with intact upstream and downstream neighboring loci, remained relatively low. Therefore, our results suggest that rearrangement of upstream sequences is an important new mechanism of hTERT promoter activation during cellular immortalization. The chromosomal rearrangements likely occurred during cellular crisis and facilitated by telomere dysfunction. Such translocations allowed the hTERT promoter to escape from the native condensed chromatin environment. PMID:19672873

A novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes

PubMed Central

Wang, Zi-Fu; Li, Ming-Hao; Chen, Wei-Wen; Hsu, Shang-Te Danny; Chang, Ta-Chau

2016-01-01

The folding topology of DNA G-quadruplexes (G4s) depends not only on their nucleotide sequences but also on environmental factors and/or ligand binding. Here, a G4 ligand, 3,6-bis(1-methyl-4-vinylpyridium iodide)-9-(1-(1-methyl-piperidinium iodide)-3,6,9-trioxaundecane) carbazole (BMVC-8C3O), can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s. Nuclear magnetic resonance (NMR) spectroscopy with hydrogen-deuterium exchange (HDX) reveals the presence of persistent imino proton signals corresponding to the central G-quartet during topological conversion of Tel23 and Tel25 G4s from hybrid to parallel forms, implying that the transition pathway mainly involves local rearrangements. In contrast, rapid HDX was observed during the transition of 22-CTA G4 from an anti-parallel form to a parallel form, resulting in complete disappearance of all the imino proton signals, suggesting the involvement of substantial unfolding events associated with the topological transition. Site-specific imino proton NMR assignments of Tel23 G4 enable determination of the interconversion rates of individual guanine bases and detection of the presence of intermediate states. Since the rate of ligand binding is much higher than the rate of ligand-induced topological conversion, a three-state kinetic model was evoked to establish the associated energy diagram for the topological conversion of Tel23 G4 induced by BMVC-8C3O. PMID:26975658

Spatiotemporal trend analysis of metal concentrations in sediments of a residential California stream with toxicity and regulatory implications.

PubMed

Hall, Lenwood W; Anderson, Ronald D; Killen, William D

2017-06-07

The objective of this study was to determine if concentrations of arsenic, cadmium, chromium, copper, lead, nickel and zinc measured in the sediments of a residential stream in California (Pleasant Grove Creek) have changed temporally or spatially from 2006 to 2016. Threshold Effect Levels (TELs), conservative ecological effects benchmarks, and exceedances for the seven metals were also evaluated over the 11-year time period to provide insight into potential metal toxicity to resident benthic communities. In addition, the bioavailability of metals in sediments was also determined by calculating Simultaneous Extracted Metal/Acid Volatle Sulfide (SEM/AVS) ratios to allow an additional assessment of toxicity. Regulatory implications of this data set and the role of metal toxicity are also discussed. Stream-wide temporal trend analysis showed no statistically significant trends for any of the metals. However, spatial analysis for several sites located near storm drains did show a significant increase for most metals over the 11-year period. TEL exceedances during the 7 years of sampling, spanning 2006-2016, were reported for all metals with the number of exceedances ranging from 47 for copper and zinc to 1 for lead. A spatial analysis showed that the highest number of TEL exceedances and the highest number of SEM/AVS ratios greater than one with at least one metal exceeding a TEL occurred at upstream sites. The potentially toxic metal concentrations reported in Pleasant Grove Creek should be used in the 303 (d) listing process for impaired water bodies in California.

Visit to the Deep Underground Science and Engineering Laboratory

ScienceCinema

None

2017-12-09

U.S. Department of Energy scientists and administrators join members of the National Science Foundation and South Dakotas Sanford Underground Laboratory for the deepest journey yet to the proposed site of the Deep Underground Science and Engineering Laboratory (DUSEL).

Visit to the Deep Underground Science and Engineering Laboratory

ScienceCinema

None

2018-05-16

U.S. Department of Energy scientists and administrators join members of the National Science Foundation and South Dakotas Sanford Underground Laboratory for the deepest journey yet to the proposed site of the Deep Underground Science and Engineering Laboratory (DUSEL).

Disparity of spectral behavior of RR Tel and RX Pup in the UV

NASA Astrophysics Data System (ADS)

Sanad, M. R.

2010-07-01

The main aim of this study is to use archival low-dispersion spectra from the International Ultraviolet Explorer (IUE) in an attempt to follow up the spectral behavior of two symbiotic Mira systems RR Tel and RX Pup of the period from 1978-1995 and 1979-1989 for two systems respectively. We concentrated on studying N IV 1486 Å intercombination line, coming from the emission nebulae ( Bryan and Kwok, 1991; Muerset et al., 1991; Murset and Nussbaumer, 1994), by calculating the line fluxes and line widths of N IV 1486 Å. We found that there is a disparity of spectral variability for these physical parameters at different times for both systems. For RR Tel, both line fluxes and line widths are increasing with the phase, while for RX Pup, both line fluxes and line widths are decreasing with the phase. There is a relation between the parameters of this emission line (line flux, line width) and phase, which we attribute to the variations of temperature of the emission nebulae at different times, as a result of the activity of the hot component.

Systematic identification of fragile sites via genome-wide location analysis of γ-H2AX

PubMed Central

Szilard, Rachel K.; Jacques, Pierre-Étienne; Laramée, Louise; Cheng, Benjamin; Galicia, Sarah; Bataille, Alain R.; Yeung, ManTek; Mendez, Megan; Bergeron, Maxime; Robert, François; Durocher, Daniel

2011-01-01

Phosphorylation of histone H2AX is an early response to DNA damage in eukaryotes. In Saccharomyces cerevisiae, DNA damage or replication fork stalling results in histone H2A phosphorylation to yield γ-H2A (yeast γ-H2AX) in a Mec1 (ATR)- and Tel1 (ATM)- dependent manner. Here, we describe the genome-wide location analysis of γ-H2A as a strategy to identify loci prone to engage the Mec1 and Tel1 pathways. Remarkably, γ-H2A enrichment overlaps with loci prone to replication fork stalling and is caused by the action of Mec1 and Tel1, indicating that these loci are prone to breakage. Moreover, about half the sites enriched for γ-H2A map to repressed protein-coding genes, and histone deacetylases are necessary for formation of γ-H2A at these loci. Finally, our work indicates that high resolution mapping of γ-H2AX is a fruitful route to map fragile sites in eukaryotic genomes. PMID:20139982

Élaboration et performances de matériaux supraconducteurs {YBa_2Cu_3O_7} massifs texturés de taille croissante

NASA Astrophysics Data System (ADS)

Chaud, X.; Gautier-Picard, P.; Beaugnon, E.; Porcar, L.; Bourgault, D.; Tournier, R.; Erraud, A.; Tixador, P.

1998-03-01

Industrial applications of the bulk superconducting YBa_2Cu_3O_7 material imply to control the growth of large oriented monodomains in samples of big size (several centimeters). The laboratory EPM-Matformag is committed to produce such materials according to three different methods (zone melting, solidification controlled by a magnetic field, crystal growth from a seed). The results obtained show that it is possible by such methods to elaborate a material with high performances at the centimeter scale and to produce it in series. The availability of such materials allows the measure of physical properties on a large scale and the testing of prototypes for cryo-electrotechnical applications (magnetic bearing, flywheel, coupling device, current lead...). Les applications industrielles des matériaux supraconducteurs massifs YBa_2Cu_3O_7 impliquent de contrôler la croissance de larges monodomaines orientés dans des échantillons de grande taille (plusieurs centimètres). Le laboratoire EPM-Matformag s'est appliqué à produire de tels matériaux selon trois techniques différentes (fusion de zone, solidification contrôlée sous champ magnétique, croissance cristalline à partir d'un germe). Les résultats obtenus montrent qu'il est possible par de telles techniques d'obtenir un matériau performant à l'échelle des centimètres et de le produire en série. La disponibilité de tels matériaux permet de mesurer des propriétés physiques à grande échelle et de tester des prototypes d'applications cryo-électrotechniques (palier magnétique, volant d'inertie, coupleur, amenée de courant, limiteur de courant...).

Performance of NACA Eight-Stage Axial-Flow Compressor Designed on the Basis of Airfoil Theory

DTIC Science & Technology

1944-08-01

TEE BASIS OF AIRFOIL THEORY By John T. Slnnette, Jr., Oscar W. Schey, and J. Austin King Aircraft Engine Research Laboratory Cleveland, Ohio FILE...efficiency can he designed by the proper application of airfoil theory. Aircraft Engine Research laboratory, Hational Advisory Committee for Aeronautlos...Basis of Airfoil Theory AUTHORS): Sinnette, John T.; Schey, Oscar W.; and others ORIGINATING AGENCY: Aircraft Engine Research Laboratory, Cleveland

Reconfiguring practice: the interdependence of experimental procedure and computing infrastructure in distributed earthquake engineering.

PubMed

De La Flor, Grace; Ojaghi, Mobin; Martínez, Ignacio Lamata; Jirotka, Marina; Williams, Martin S; Blakeborough, Anthony

2010-09-13

When transitioning local laboratory practices into distributed environments, the interdependent relationship between experimental procedure and the technologies used to execute experiments becomes highly visible and a focal point for system requirements. We present an analysis of ways in which this reciprocal relationship is reconfiguring laboratory practices in earthquake engineering as a new computing infrastructure is embedded within three laboratories in order to facilitate the execution of shared experiments across geographically distributed sites. The system has been developed as part of the UK Network for Earthquake Engineering Simulation e-Research project, which links together three earthquake engineering laboratories at the universities of Bristol, Cambridge and Oxford. We consider the ways in which researchers have successfully adapted their local laboratory practices through the modification of experimental procedure so that they may meet the challenges of coordinating distributed earthquake experiments.

Semiconductor Chemical Reactor Engineering and Photovoltaic Unit Operations.

ERIC Educational Resources Information Center

Russell, T. W. F.

1985-01-01

Discusses the nature of semiconductor chemical reactor engineering, illustrating the application of this engineering with research in physical vapor deposition of cadmium sulfide at both the laboratory and unit operations scale and chemical vapor deposition of amorphous silicon at the laboratory scale. (JN)

Elevating Learner Achievement Using Formative Electronic Lab Assessments in the Engineering Laboratory: A Viable Alternative to Weekly Lab Reports

ERIC Educational Resources Information Center

Chen, Baiyun; DeMara, Ronald F.; Salehi, Soheil; Hartshorne, Richard

2018-01-01

A laboratory pedagogy interweaving weekly student portfolios with onsite formative electronic laboratory assessments (ELAs) is developed and assessed within the laboratory component of a required core course of the electrical and computer engineering (ECE) undergraduate curriculum. The approach acts to promote student outcomes, and neutralize…

Collaborative Model for Remote Experimentation Laboratories Used by Non-Hierarchical Distributed Groups of Engineering Students

ERIC Educational Resources Information Center

Herrera, Oriel A.; Fuller, David A.

2011-01-01

Remote experimentation laboratories (REL) are systems based on real equipment that allow students to carry out a laboratory practice through the Internet on the computer. In engineering, there have been numerous initiatives to implement REL over recent years, given the fundamental role of laboratory activities. However, in the past efforts have…

Pilot-Scale Laboratory Instruction for Chemical Engineering: The Specific Case of the Pilot-Unit Leading Group

ERIC Educational Resources Information Center

Billet, Anne-Marie; Camy, Severine; Coufort-Saudejaud, Carole

2010-01-01

This paper presents an original approach for Chemical Engineering laboratory teaching that is currently applied at INP-ENSIACET (France). This approach, referred to as "pilot-unit leading group" is based on a partial management of the laboratories by the students themselves who become temporarily in charge of one specific laboratory. In…

75 FR 15675 - Professional Research Experience Program in Chemical Science and Technology Laboratory...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-30

... in physics, chemistry, mathematics, computer science, or engineering. Institutions should have a 4..., mathematics, computer science, or engineering with work experiences in laboratories or other settings...-0141-01] Professional Research Experience Program in Chemical Science and Technology Laboratory...

The Development and Evaluation of Industrial Case Studies to Support a New Laboratory Course in Electrical Engineering.

ERIC Educational Resources Information Center

Bolton, B.; Adderley, K. J.

1978-01-01

After viewing videotaped case studies indicating the relevance of electrical laboratory work to professional engineers, student attitudes showed a positive improvement toward laboratory work. Semantic differential tests, questionnaires, and interviews were used. (Author/MH)

Facilities | Argonne National Laboratory

Science.gov Websites

Skip to main content Argonne National Laboratory Toggle Navigation Toggle Search Research Facilities Advanced Powertrain Research Facility Center for Transportation Research Distributed Energy Research Center Engine Research Facility Heat Transfer Laboratory Materials Engineering Research Facility

Circular dichroism spectroscopic investigation of double-decker phthalocyanine with G-Quadruplex as promising telomerase inhibitor

NASA Astrophysics Data System (ADS)

Baǧda, Efkan; Baǧda, Esra; Yabaş, Ebru

2017-01-01

In the present study, interaction of a double-decker phthalocyanine with two G-quadruplex DNA, Tel 21 and cMYC, was investigated. To the best of our knowledge, this is the first study about G-quadruplex-double decker phthalocyanine interaction. The spectrophotometric titration method was used for binding constant calculations. From the binding constants, it can be said that double-decker phthalocyanine more likely to bind Tel 21 rather than cMYC. The conformational changes upon binding were monitored via circular dichroism spectroscopy. The ethidium bromide replacement assay was investigated spectrofluorometrically.

[Statistics of the activities of a veterinarian from the Canton of Neuchâtel from the 19th century].

PubMed

Rutti, A

2017-01-01

Abraham Buehler wrote a statistical sketch of his activity as a practitioner during the years 1855 to 1861 in "Les Verrières" in the Swiss Canton of Neuchâtel. He included charts relating to diseases observed in different species such as horses, cows, goats, sheep, pigs and dogs. He described the evolution of the foot and mouth epidemic in the region during the years 1855 and 1856. Abraham Buehler stated that with this work he aimed to encourage his colleagues to also collect data.

Ongoing hepatitis A among men who have sex with men (MSM) linked to outbreaks in Europe in Tel Aviv area, Israel, December 2016 – June 2017

PubMed Central

Gozlan, Yael; Bar-Or, Itay; Rakovsky, Aviya; Savion, Michal; Amitai, Ziva; Sheffer, Rivka; Ceder, Noa; Anis, Emilia; Grotto, Itamar; Mendelson, Ella; Mor, Orna

2017-01-01

Between December 2016 and June 2017, 19 Hepatitis A virus (HAV)-positive cases, 17 of which were among men who have sex with men (MSM) were identified in the Tel Aviv area. Seven of the 15 sewage samples collected between January and June 2017 were also HAV-positive. All sequences clustered with two of the three strains identified in the current European HAV outbreak. We demonstrate that despite an efficient vaccination programme, HAV can still be transmitted to an unvaccinated high-risk population. PMID:28749336

Multi-disciplinary study for the exploration of deep low enthalpy geothermal reservoirs, Neuchâtel, Switzerland

NASA Astrophysics Data System (ADS)

Mauri, G.; Abdelfettah, Y.; Negro, F.; Schill, E.; Vuataz, F.

2011-12-01

The authorities of the canton of Neuchâtel, in the Western part of Switzerland, are willing to develop geothermal energy for district heating in the two main cities of the canton: Neuchâtel, located along the Lake of Neuchâtel, and La Chaux-de-Fonds situated in a high valley of the Jura Massif. The geology of both areas is linked to the Jura Range and present complex structures, where the landscape is composed of anticlines associated with overthrust faults, which are overcut by strike-slip fault and secondary faulting events. The rock formations go from the Trias, which forms the detachment layer, up to the Quaternary rock. Bedrocks are mainly composed of limestones and marls, which can reach a thickness of several hundreds meters. The three main deep aquifers investigated in this area, from the shallowest (≤ 400 m below surface) to deepest (< 2000 m), are the Malm, the Dogger and the Muschelkalk. The estimated temperatures, based on previous studies, should range between 20 to 65 oC, which are function of depth, elevation and groundwater velocity. The expected low temperature is mainly due to the presence of karstic systems, which drains the heat towards the low elevation of the basin. The present study is based on gravimetry surveys, 3D geological models and 3D gravimetry models to best characterize the underground structures and to find areas where the rock properties would be favourable to geothermal exploitation. This means targets where permeability and porosity are high in the potential aquifers, allowing a significant flow at the future production wells. The results indicate that gravity anomalies are associated with both shallow and deep geological structures in the two exploration sites and that high resolution of dense grid gravity measurements combined with realistic 3D models of the geological structures allow to characterize interesting features for deep geothermal exploration. Gravity corrections were carried out with a computing code using different DEM resolution ranging from a very high resolution (0.5 m pixel in the vicinity of each station) toward a lower resolution (25 m for the distal areas as far as 110 km away from each station). The bathymetry of the Lake of Neuchâtel (218 km2) has been used to correct gravity effects from the large volume of water along the Lake shore of Neuchâtel. The combination of 3D geological models with a high resolution gravity survey allows to better constrain the geometry of the Triassic formation, just above the detachment layer, as well to quantify the karstic processes, which could affect the three deep aquifers.

[Online text-based psychosocial intervention for Youth in Quebec].

PubMed

Thoër, Christine; Noiseux, Kathia; Siche, Fabienne; Palardy, Caroline; Vanier, Claire; Vrignaud, Caroline

In 2013, Tel-jeunes created a text messaging intervention program to reach youth aged 12 to 17 years on their cell phones. Tel-jeunes was the first in the country to offer a text-based brief psychosocial interventions performed by professional counselors. Researchers were contacted to document and evaluate the program. The research aimed to: 1) determine motives, contexts and issues that lead young people to use the SMS service; 2) document the characteristics of text-based brief intervention; and 3) assess the advantages and difficulties encountered by counselors who respounded to youth text-messages. We conducted a multimethod research from November 2013 to May 2014. We held four focus groups with 23 adolescents aged 15 to 17 who had or not used the SMS service, conducted a content analysis of a corpus of 13,236 text messages (or 601 conversations), and two focus groups with 11 Tel-jeunes counselors, just over a year after the implantation of the service. Our findings show that the SMS service meets youth needs. They identify text messaging to be their prefered mode of communication with Tel-jeunes when they need support or information. Moreover, the service reaches young people who would not have felt confortable to contact Tel-jeunes by phone. We identified three dominant issues in youths demands: romantic relationships, psychological health and sexuality. Perceived benefits of the service include anonimity and privacy (cell phone providing the ability to text anywhere). Youth participants also appreciated writing to counselors as they felt they had more time to think abouth their questions and answers to the counselor. Counselors were more ambivalent. They considered text-based intervention to be very effective and satisfactory to adress youth information requests, but reported difficulties when dealing with more complex problems or with mental health issues. They reported that text-based communication makes it more difficult to assess youth emotional states, found the discontinuity of text-based conversations very frustrating, and experienced problems when dealing with several youth at the same time. They also struggled with some the computer-based platform features. Finding suggest that text-based intervention are now essential to reach out to youth seeking for information and help. But, Tel-jeunes text-based service required adaptations of the intervention model. Adjustment were made by the managment team when implementing the service which required taking into account youth needs, engaging in a continuous dialogue with counselors and working with the suppliers of the text-based platform to improve its features. Futur challenges include reaching out for boys, conducting interventions with younger youth who feel confortable contacting the service by SMS, and managing urgent requests initiated via web text-messaging apps rather than mobile phones.

Real-Time Rocket/Vehicle System Integrated Health Management Laboratory For Development and Testing of Health Monitoring/Management Systems

NASA Technical Reports Server (NTRS)

Aguilar, R.

2006-01-01

Pratt & Whitney Rocketdyne has developed a real-time engine/vehicle system integrated health management laboratory, or testbed, for developing and testing health management system concepts. This laboratory simulates components of an integrated system such as the rocket engine, rocket engine controller, vehicle or test controller, as well as a health management computer on separate general purpose computers. These general purpose computers can be replaced with more realistic components such as actual electronic controllers and valve actuators for hardware-in-the-loop simulation. Various engine configurations and propellant combinations are available. Fault or failure insertion capability on-the-fly using direct memory insertion from a user console is used to test system detection and response. The laboratory is currently capable of simulating the flow-path of a single rocket engine but work is underway to include structural and multiengine simulation capability as well as a dedicated data acquisition system. The ultimate goal is to simulate as accurately and realistically as possible the environment in which the health management system will operate including noise, dynamic response of the engine/engine controller, sensor time delays, and asynchronous operation of the various components. The rationale for the laboratory is also discussed including limited alternatives for demonstrating the effectiveness and safety of a flight system.

Virtual laboratory learning media development to improve science literacy skills of mechanical engineering students on basic physics concept of material measurement

NASA Astrophysics Data System (ADS)

Jannati, E. D.; Setiawan, A.; Siahaan, P.; Rochman, C.

2018-05-01

This study aims to determine the description of virtual laboratory learning media development to improve science literacy skills of Mechanical Engineering students on the concept of basic Physics. Quasi experimental method was employed in this research. The participants of this research were first semester students of mechanical engineering in Majalengka University. The research instrument was readability test of instructional media. The results of virtual laboratory learning media readability test show that the average score is 78.5%. It indicates that virtual laboratory learning media development are feasible to be used in improving science literacy skill of Mechanical Engineering students in Majalengka University, specifically on basic Physics concepts of material measurement.

Environmental Engineering Unit Operations and Unit Processes Laboratory Manual.

ERIC Educational Resources Information Center

O'Connor, John T., Ed.

This manual was prepared for the purpose of stimulating the development of effective unit operations and unit processes laboratory courses in environmental engineering. Laboratory activities emphasizing physical operations, biological, and chemical processes are designed for various educational and equipment levels. An introductory section reviews…

FY04 Engineering Technology Reports Technology Base

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sharpe, R M

2005-01-27

Lawrence Livermore National Laboratory's Engineering Directorate has two primary discretionary avenues for its investment in technologies: the Laboratory Directed Research and Development (LDRD) program and the ''Tech Base'' program. This volume summarizes progress on the projects funded for technology-base efforts in FY2004. The Engineering Technical Reports exemplify Engineering's more than 50-year history of researching and developing (LDRD), and reducing to practice (technology-base) the engineering technologies needed to support the Laboratory's missions. Engineering has been a partner in every major program and project at the Laboratory throughout its existence, and has prepared for this role with a skilled workforce and technicalmore » resources. This accomplishment is well summarized by Engineering's mission: ''Enable program success today and ensure the Laboratory's vitality tomorrow''. LDRD is the vehicle for creating those technologies and competencies that are cutting edge. These require a significant level of research or contain some unknown that needs to be fully understood. Tech Base is used to apply those technologies, or adapt them to a Laboratory need. The term commonly used for Tech Base projects is ''reduction to practice''. Tech Base projects effect the natural transition to reduction-to-practice of scientific or engineering methods that are well understood and established. They represent discipline-oriented, core competency activities that are multi-programmatic in application, nature, and scope. The objectives of technology-base funding include: (1) the development and enhancement of tools and processes to provide Engineering support capability, such as code maintenance and improved fabrication methods; (2) support of Engineering science and technology infrastructure, such as the installation or integration of a new capability; (3) support for technical and administrative leadership through our technology Centers; and (4) the initial scoping and exploration of selected technology areas with high strategic potential, such as assessment of university, laboratory, and industrial partnerships. Engineering's five Centers, in partnership with the Division Leaders and Department Heads, focus and guide longer-term investments within Engineering. The Centers attract and retain top staff, develop and maintain critical core technologies, and enable programs. Through their technology-base projects, they oversee the application of known engineering approaches and techniques to scientific and technical problems. The Centers and their Directors are as follows: (1) Center for Computational Engineering: Robert M. Sharpe; (2) Center for Microtechnology and Nanotechnology: Raymond P. Mariella, Jr. (3) Center for Nondestructive Characterization: Harry E. Martz, Jr.; (4) Center for Precision Engineering: Keith Carlisle; and (5) Center for Complex Distributed Systems: Gregory J. Suski, Acting Director.« less

Information engineering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunt, D.N.

1997-02-01

The Information Engineering thrust area develops information technology to support the programmatic needs of Lawrence Livermore National Laboratory`s Engineering Directorate. Progress in five programmatic areas are described in separate reports contained herein. These are entitled Three-dimensional Object Creation, Manipulation, and Transport, Zephyr:A Secure Internet-Based Process to Streamline Engineering Procurements, Subcarrier Multiplexing: Optical Network Demonstrations, Parallel Optical Interconnect Technology Demonstration, and Intelligent Automation Architecture.

A Three-Year Feedback Study of a Remote Laboratory Used in Control Engineering Studies

ERIC Educational Resources Information Center

Chevalier, Amélie; Copot, Cosmin; Ionescu, Clara; De Keyser, Robin

2017-01-01

This paper discusses the results of a feedback study for a remote laboratory used in the education of control engineering students. The goal is to show the effectiveness of the remote laboratory on examination results. To provide an overview, the two applications of the remote laboratory are addressed: 1) the Stewart platform, and 2) the quadruple…

Optimization of In-Cylinder Pressure Filter for Engine Research

DTIC Science & Technology

2017-06-01

ARL-TR-8034 ● JUN 2017 US Army Research Laboratory Optimization of In-Cylinder Pressure Filter for Engine Research by Kenneth...Laboratory Optimization of In-Cylinder Pressure Filter for Engine Research by Kenneth S Kim, Michael T Szedlmayer, Kurt M Kruger, and Chol-Bum M...

Soil-Structure Interaction Study of Red River Lock and Dam No. 1 Subjected to Sediment Loading

DTIC Science & Technology

1993-09-01

Sediment Loading by Robert M. Ebeling, Reed L. Mosher, Kevin Abraham Information Technology Laboratory John F. Peters Geotechnical Laboratory DTIC fl ELECTE...Robert M. Ebeling, Reed L. Mosher, Kevin Abraham Information Technology Laboratory John F. Peters Geotechnical Laboratory U.S. Army Corps of Engineers...Division (CAED), Informa- tion Technology Laboratory (ITL), Dr. Reed L. Mosher, Acting Chief, CAED, Mr. Kevin Abraham, Scientific and Engineering

Annotated bibliography of Software Engineering Laboratory literature

NASA Technical Reports Server (NTRS)

1985-01-01

An annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory is presented. More than 100 publications are summarized. These publications are summarized. These publications cover many areas of software engineering and range from research reports to software documentation. This document has been updated and reorganized substantially since the original version (SEL-82-006, November 1982). All materials are grouped into five general subject areas for easy reference: (1) the software engineering laboratory; (2) software tools; (3) models and measures; (4) technology evaluations; and (5) data collection. An index further classifies these documents by specific topic.

Laboratory and Pilot Scale Evaluation of Coagulation, Clarification, and Filtration for Upgrading Sewage Lagoon Effluents.

DTIC Science & Technology

1980-08-01

AD-AGAB 906 ARMY ENGINEER WATERWAYS EXPERIMENT STATION VICKSBURG--ETC FIG 14/2 LABORATORY AND PILOT SCALE EVALUATION OF COAGULATION, CLARIFICA -ETC U...FILTRATION FOR LWGRADING JEWAGE LAGOON EFFLUENTS~ w IL j0 ( M John ullinane, Jr., Richard A. hafer (0 Environmental Laboratory gel U. S. Army Engineer ...Shafer 9. PERFORMING ORGANIZATION NAME AND ADORESS SO. PROGRAM ELEMENT, PROJECT, TASK AREA a WORK UNIT NUMBERS U. S. Army Engineer Waterways Experiment

Quality Assessment and Accessibility Applications of Crowdsourced Geospatial Data: A Report on the Development and Extension of the George Mason University Geocrowdsourcing Testbed

DTIC Science & Technology

2014-09-01

Approved for public release; distribution is unlimited. Prepared for Geospatial Research Laboratory U.S. Army Engineer Research and Development...Center U.S. Army Corps of Engineers Under Data Level Enterprise Tools Monitored by Geospatial Research Laboratory 7701 Telegraph Road...Engineer Research and Development Center (ERDC) ERDC Geospatial Research Laboratory 7701 Telegraph Road 11. SPONSOR/MONITOR’S REPORT Alexandria, VA 22135

[Multimedia (visual collaboration) brings true nature of human life].

PubMed

Tomita, N

2000-03-01

Videoconferencing system, high-quality visual collaboration, is bringing Multimedia into a society. Multimedia, high quality media such as TV broadcast, looks expensive because it requires broadband network with 100-200 Mpbs bandwidth or 3,700 analog telephone lines. However, thanks to the existing digital-line called N-ISDN (Narrow Integrated Service Digital Network) and PictureTel's audio/video compression technologies, it becomes far less expensive. N-ISDN provides 128 Kbps bandwidth, over twice wider than analog line. PictureTel's technology instantly compress audio/video signal into 1/1,000 in size. This means, with ISDN and PictureTel technology. Multimedia is materialized over even single ISDN line. This will allow doctor to remotely meet face-to-face with a medical specialist or patients to interview, conduct physical examinations, review records, and prescribe treatments. Bonding multiple ISDN lines will further improve video quality that enables remote surgery. Surgeon can perform an operation on internal organ by projecting motion video from Endoscope's CCD camera to large display monitor. Also, PictureTel provides advanced technologies of eliminating background noise generated by surgical knives or scalpels during surgery. This will allow sound of the breath or heartbeat be clearly transmitted to the remote site. Thus, Multimedia eliminates the barrier of distance, enabling people to be just at home, to be anywhere in the world, to undergo up-to-date medical treatment by expertise. This will reduce medical cost and allow people to live in the suburbs, in less pollution, closer to the nature. People will foster more open and collaborative environment by participating in local activities. Such community-oriented life-style will atone for mass consumption, materialistic economy in the past, then bring true happiness and welfare into our life after all.

Two Siblings with Alternate Unbalanced Recombinants Derived from a Large Cryptic Maternal Pericentric Inversion of Chromosome 20

PubMed Central

DeScipio, Cheryl; Morrissette, Jennifer J.D.; Conlin, Laura K.; Clark, Dinah; Kaur, Maninder; Coplan, James; Riethman, Harold; Spinner, Nancy B.; Krantz, Ian D.

2009-01-01

Two brothers, with dissimilar clinical features, were each found to have different abnormalities of chromosome 20 by subtelomere fluorescence in situ hybridization (FISH). The proband had deletion of 20p subtelomere and duplication of 20q subtelomere, while his brother was found to have a duplication of 20p subtelomere and deletion of 20q subtelomere. Parental cytogenetic studies were initially thought to be normal, both by G-banding and by subtelomere FISH analysis. Since chromosome 20 is a metacentric chromosome and an inversion was suspected, we used anchored FISH to assist in identifying a possible inversion. This approach employed concomitant hybridization of a FISH probe to the short (p) arm of chromosome 20 with the 20q subtelomere probe. We identified a cytogenetically non-visible, mosaic pericentric inversion of one of the maternal chromosome 20 homologues, providing a mechanistic explanation for the chromosomal abnormalities present in these brothers. Array comparative genomic hybridization (CGH) with both a custom-made BAC and cosmid-based subtelomere specific array (TEL array) and a commercially-available SNP-based array confirmed and further characterized these rearrangements, identifying this as the largest pericentric inversion of chromosome 20 described to date. TEL array data indicate that the 20p breakpoint is defined by BAC RP11-978M13, ~900 kb from the pter; SNP array data reveal this breakpoint to occur within BAC RP11-978M13. The 20q breakpoint is defined by BAC RP11-93B14, ~1.7 Mb from the qter, by TEL array; SNP array data refine this breakpoint to within a gap between BACs on the TEL array (i.e. between RP11-93B14 and proximal BAC RP11-765G16). PMID:20101690

The Handover Toolbox: a knowledge exchange and training platform for improving patient care.

PubMed

Drachsler, Hendrik; Kicken, Wendy; van der Klink, Marcel; Stoyanov, Slavi; Boshuizen, Henny P A; Barach, Paul

2012-12-01

Safe and effective patient handovers remain a global organisational and training challenge. Limited evidence supports available handover training programmes. Customisable training is a promising approach to improve the quality and sustainability of handover training and outcomes. We present a Handover Toolbox designed in the context of the European HANDOVER Project. The Toolbox aims to support physicians, nurses, individuals in health professions training, medical educators and handover experts by providing customised handover training tools for different clinical needs and contexts. The Handover Toolbox uses the Technology Enhanced Learning Design Process (TEL-DP), which encompasses user requirements analysis; writing personas; group concept mapping; analysis of suitable software; plus, minus, interesting rating; and usability testing. TEL-DP is aligned with participatory design approaches and ensures development occurs in close collaboration with, and engagement of, key stakeholders. Application of TEL-DP confirmed that the ideal formats of handover training differs for practicing professionals versus individuals in health profession education programmes. Training experts from different countries differed in their views on the optimal content and delivery of training. Analysis of suitable software identified ready-to-use systems that provide required functionalities and can be further customised to users' needs. Interest rating and usability testing resulted in improved usability, navigation and uptake of the Handover Toolbox. The design of the Handover Toolbox was based on a carefully led stakeholder participatory design using the TEL-DP approach. The Toolbox supports a customisable learning approach that allows trainers to design training that addresses the specific information needs of the various target groups. We offer recommendations regarding the application of the Handover Toolbox to medical educators.

Two siblings with alternate unbalanced recombinants derived from a large cryptic maternal pericentric inversion of chromosome 20.

PubMed

Descipio, Cheryl; Morrissette, Jennifer D; Conlin, Laura K; Clark, Dinah; Kaur, Maninder; Coplan, James; Riethman, Harold; Spinner, Nancy B; Krantz, Ian D

2010-02-01

Two brothers, with dissimilar clinical features, were each found to have different abnormalities of chromosome 20 by subtelomere fluorescence in situ hybridization (FISH). The proband had deletion of 20p subtelomere and duplication of 20q subtelomere, while his brother was found to have a duplication of 20p subtelomere and deletion of 20q subtelomere. Parental cytogenetic studies were initially thought to be normal, both by G-banding and by subtelomere FISH analysis. Since chromosome 20 is a metacentric chromosome and an inversion was suspected, we used anchored FISH to assist in identifying a possible inversion. This approach employed concomitant hybridization of a FISH probe to the short (p) arm of chromosome 20 with the 20q subtelomere probe. We identified a cytogenetically non-visible, mosaic pericentric inversion of one of the maternal chromosome 20 homologs, providing a mechanistic explanation for the chromosomal abnormalities present in these brothers. Array comparative genomic hybridization (CGH) with both a custom-made BAC and cosmid-based subtelomere specific array (TEL array) and a commercially available SNP-based array confirmed and further characterized these rearrangements, identifying this as the largest pericentric inversion of chromosome 20 described to date. TEL array data indicate that the 20p breakpoint is defined by BAC RP11-978M13, approximately 900 kb from the pter; SNP array data reveal this breakpoint to occur within BAC RP11-978M13. The 20q breakpoint is defined by BAC RP11-93B14, approximately 1.7 Mb from the qter, by TEL array; SNP array data refine this breakpoint to within a gap between BACs on the TEL array (i.e., between RP11-93B14 and proximal BAC RP11-765G16). Copyright 2010 Wiley-Liss, Inc.

Same-sex sexual attraction, behavior, and practices of Jewish men in Israel and the association with HIV prevalence

PubMed Central

Mor, Zohar; Davidovich, Udi

2016-01-01

ABSTRACT In order to efficiently direct efforts and resources required for the prevention of HIV and other sexually transmitted infection among men who have sex with men (MSM) in Israel, it is necessary to define their particular behaviors, estimate their size, and asses the HIV-burden. This cross-sectional study included a sub-sample from a random representative National study performed in Israel, which included Jewish males aged 18–44 who completed online anonymous questionnaires regarding their sexual attraction and practices, commercial sex-work, as well as condom and substances' use. Additionally, participants were asked to identify themselves as gay, bisexual, or heterosexual. National estimates regarding prevalence of risk-behaviors and HIV-infection among MSM were based on the Statistical Abstract of Israel and the National HIV Registry, respectively. Of the total sample of 997 men, 11.9% reported lifetime male sex encounters, while 4.5% and 3.7% self-identified as gay or bisexual, respectively. The estimated population of self-identified Jewish gays/bisexuals aged 18–44 in Israel was 94,176, and in Tel-Aviv 33,839. HIV prevalence among MSM was estimated at 0.7% in Israel and 1.0% in Tel-Aviv. MSM were more likely to live in Tel-Aviv, had higher levels of education, and were scored higher on several determinants of sexual risk in comparison to those attracted to women, including early sexual debut, greater number of sexual partners, ever paid/been paid for sex, sexually coerced, and substance use. In conclusion, MSM were involved in greater risk behaviors than those who only had female sex partners. Most MSM were living in Tel-Aviv and their estimated HIV prevalence was 1.0%. PMID:26883581

Same-sex sexual attraction, behavior, and practices of Jewish men in Israel and the association with HIV prevalence.

PubMed

Mor, Zohar; Davidovich, Udi

2016-01-01

In order to efficiently direct efforts and resources required for the prevention of HIV and other sexually transmitted infection among men who have sex with men (MSM) in Israel, it is necessary to define their particular behaviors, estimate their size, and asses the HIV-burden. This cross-sectional study included a sub-sample from a random representative National study performed in Israel, which included Jewish males aged 18-44 who completed online anonymous questionnaires regarding their sexual attraction and practices, commercial sex-work, as well as condom and substances' use. Additionally, participants were asked to identify themselves as gay, bisexual, or heterosexual. National estimates regarding prevalence of risk-behaviors and HIV-infection among MSM were based on the Statistical Abstract of Israel and the National HIV Registry, respectively. Of the total sample of 997 men, 11.9% reported lifetime male sex encounters, while 4.5% and 3.7% self-identified as gay or bisexual, respectively. The estimated population of self-identified Jewish gays/bisexuals aged 18-44 in Israel was 94,176, and in Tel-Aviv 33,839. HIV prevalence among MSM was estimated at 0.7% in Israel and 1.0% in Tel-Aviv. MSM were more likely to live in Tel-Aviv, had higher levels of education, and were scored higher on several determinants of sexual risk in comparison to those attracted to women, including early sexual debut, greater number of sexual partners, ever paid/been paid for sex, sexually coerced, and substance use. In conclusion, MSM were involved in greater risk behaviors than those who only had female sex partners. Most MSM were living in Tel-Aviv and their estimated HIV prevalence was 1.0%.

Using the failure mode and effects analysis model to improve parathyroid hormone and adrenocorticotropic hormone testing

PubMed Central

Magnezi, Racheli; Hemi, Asaf; Hemi, Rina

2016-01-01

Background Risk management in health care systems applies to all hospital employees and directors as they deal with human life and emergency routines. There is a constant need to decrease risk and increase patient safety in the hospital environment. The purpose of this article is to review the laboratory testing procedures for parathyroid hormone and adrenocorticotropic hormone (which are characterized by short half-lives) and to track failure modes and risks, and offer solutions to prevent them. During a routine quality improvement review at the Endocrine Laboratory in Tel Hashomer Hospital, we discovered these tests are frequently repeated unnecessarily due to multiple failures. The repetition of the tests inconveniences patients and leads to extra work for the laboratory and logistics personnel as well as the nurses and doctors who have to perform many tasks with limited resources. Methods A team of eight staff members accompanied by the Head of the Endocrine Laboratory formed the team for analysis. The failure mode and effects analysis model (FMEA) was used to analyze the laboratory testing procedure and was designed to simplify the process steps and indicate and rank possible failures. Results A total of 23 failure modes were found within the process, 19 of which were ranked by level of severity. The FMEA model prioritizes failures by their risk priority number (RPN). For example, the most serious failure was the delay after the samples were collected from the department (RPN =226.1). Conclusion This model helped us to visualize the process in a simple way. After analyzing the information, solutions were proposed to prevent failures, and a method to completely avoid the top four problems was also developed. PMID:27980440

Stationary Engineering Laboratory Manual--2.

ERIC Educational Resources Information Center

Steingress, Frederick M.; Frost, Harold J.

The Stationary Engineering Laboratory Manual 2 was designed for vocational/technical high school students who have received instruction in the basics of stationary engineering. It was developed for students who will be operating a live plant and who will be responsible for supplying steam for heating, cooking, and baking. Each lesson in the manual…

Learning by Brewing: Beer Production Experiments in the Chemical Engineering Laboratory

ERIC Educational Resources Information Center

Cerretani, Colin; Kelkile, Esayas; Landry, Alexandra

2017-01-01

We discuss the successful creation and implementation of a biotechnology track within the chemical engineering unit operations course. The track focuses on engineering principles relevant to brewing. Following laboratory modules investigating heat transfer processes and yeast fermentation kinetics, student groups design and implement a project to…

An Undergraduate Nanotechnology Engineering Laboratory Course on Atomic Force Microscopy

ERIC Educational Resources Information Center

Russo, D.; Fagan, R. D.; Hesjedal, T.

2011-01-01

The University of Waterloo, Waterloo, ON, Canada, is home to North America's first undergraduate program in nanotechnology. As part of the Nanotechnology Engineering degree program, a scanning probe microscopy (SPM)-based laboratory has been developed for students in their fourth year. The one-term laboratory course "Nanoprobing and…

Pedagogical Evaluation of Remote Laboratories in eMerge Project

ERIC Educational Resources Information Center

Lang, Daniela; Mengelkamp, Christoph; Jaeger, Reinhold S.; Geoffroy, Didier; Billaud, Michel; Zimmer, Thomas

2007-01-01

This study investigates opportunities for conducting electrical engineering experiments via the Internet rather than in an actual laboratory. Eighty-four French students of electrical engineering (semester 1, 2004) at Bordeaux University 1 participated in practical courses. Half of the students performed experiments in a laboratory while the other…

Laboratory for Oceans

NASA Technical Reports Server (NTRS)

1988-01-01

A review is made of the activities of the Laboratory for Oceans. The staff and the research activities are nearly evenly divided between engineering and scientific endeavors. The Laboratory contributes engineering design skills to aircraft and ground based experiments in terrestrial and atmospheric sciences in cooperation with scientists from labs in Earth sciences.

Laboratory Barriers in Science, Engineering, and Mathematics for Students with Disabilities.

ERIC Educational Resources Information Center

Heidari, Farzin

This report addresses the barriers college students with disabilities face in the laboratory setting. In engineering, mathematics, and science education most courses require laboratory work which may pose challenges to those with disabilities. Instructors should be aware of the individual needs of students with disabilities and make necessary…

Supercritical and Transcritical Real-Fluid Mixing in Diesel Engine Applications

DTIC Science & Technology

2015-09-01

ARL-RP-0551 ● SEP 2015 US Army Research Laboratory Supercritical and Transcritical Real-Fluid Mixing in Diesel Engine...ARL-RP-0551 ● SEP 2015 US Army Research Laboratory Supercritical and Transcritical Real-Fluid Mixing in Diesel Engine Applications by...COVERED (From - To) 1 January 2014–30 September 2014 4. TITLE AND SUBTITLE Supercritical and Transcritical Real-Fluid Mixing in Diesel Engine

Coronal Properties of X-ray bright stars in young associations: abundances, temperatures and variability

NASA Astrophysics Data System (ADS)

Argiroffi, Costanza

2006-03-01

In this work I have investigated open issues related to the X-ray radiation from young stars, including heating mechanisms of the emitting plasma, its chemical composition, and possible effects due to circumstellar accretion disks. To this aim, I have analyzed observations of young nearby stars taken with the X-ray observatories XMM-Newton and Chandra. For a detailed study of the characteristics of the X-ray emitting plasma, I have selected two X-ray bright young stars, TWA 5 and PZ Tel, for which high-resolution X-ray spectroscopy was achievable, and two regions of the young stellar association Upper Scorpius (USco), for which X-ray images and medium-resolution spectra of individual sources were obtained. TWA 5 is a 10 Myr old star in the TW Hydrae association, which is still accreting material from its circumstellar envelope, while PZ Tel is a ? 12 Myr star in the beta Pictoris moving group, which already dissipated its circumstellar disk. The different evolutionary stages of these two stars allow to probe whether X-ray emission is produced, or affected, by accretion processes. High-resolution X-ray spectra of TWA 5 and PZ Tel were gathered with the grating spectrometers on board XMM-Newton and Chandra, respectively. From the measurements of individual emission line fluxes in their X-ray spectra, I have derived emission measure distributions vs. temperature, abundances, and electron densities of the X-ray emitting plasma. I have found that, in spite of their different evolutionary status, hot (T ? 10 MK) plasma is the main responsible for the observed X-ray emission of both stars. The hot plasma on TWA 5 displays peculiar element abundances with respect to the solar photospheric composition with Ne/Fe ? 10(Ne/Fe), while the coronal plasma on PZ Tel shows Ne/Fe ? 3(Ne/Fe). To explain the strong Fe underabundance (? 0.1 Fe) and the extremely high Ne/Fe ratio of TWA 5 I have considered three different scenarios: (1) coronal plasma may be affected by selective element depletion dependent on the first ionization potential (FIP), similar to the inverse FIP effect usually observed in the coronae of very active stars; (2) the X-ray emitting plasma on TWA 5 may be partially heated by the shock produced by the infall accretion streams onto the stellar photosphere, and hence it may originate from the circumstellar disk, where grain depletion is a possible cause of the metal deficiency; (3) the peculiar abundances on TWA 5 are due to the local chemical composition of the original cloud from which the star formed, and this explains why TWA 5 shares the same abundances with TW Hydrae, another young star located in the same stellar association. The 5 Myr old USco association, due to its vicinity (145 pc) and low circumstellar extinction, is a good laboratory to perform a detailed study of PMS stars of this age. Here I present the results of the analysis of deep XMM-Newton observations of two USco regions covering an area of ?0.4 deg^2 . I have detected 224 X-ray sources among which 22 have been identified with probable USco members on the basis of near infrared and optical photometry. Among these 22 sources, I have recognized 13 sources as USco members for the first time. Except for the intermediate mass star HD 142578, all the detected USco sources are low mass stars of spectral type ranging from G to late M, and including at least one brown dwarf. The X-ray spectral analysis of the most intense USco sources indicates metal depleted plasma with temperature of ? 10 MK, resembling the typical case of active main sequence stars, as already found for TWA 5 and PZ Tel. Strong flares detected from 4 USco members have allowed me to derive coronal lengths of the flaring structures by performing time resolved spectroscopy during the flare decay phases. In all cases the flaring loops have sizes of 10^10 - 10^11 cm, hence smaller than the corresponding stellar radii. These results suggest that, in these very young stars coronal plasma is confined in compact loops. The coronal properties of PZ Tel, TWA 5, and of the USco members indicate that the coronae of pre-main sequence stars become similar to those of older active main-sequence stars on short time scales (? 5 Myr), in terms of average temperature, density, elemental abundances, and loop lengths, even if accretion processes from circumstellar disks are still at work.

Full-participation of students with physical disabilities in science and engineering laboratories.

PubMed

Jeannis, Hervens; Joseph, James; Goldberg, Mary; Seelman, Katherine; Schmeler, Mark; Cooper, Rory A

2018-02-01

To conduct a literature review identifying barriers and facilitators students with physical disabilities (SwD-P) may encounter in science and engineering (S&E) laboratories. Publications were identified from 1991 to 2015 in ERIC, web of science via web of knowledge, CINAHL, SCOPUS, IEEEXplore, engineering village, business source complete and PubMed databases using search terms and synonyms for accommodations, advanced manufacturing, additive manufacturing, assistive technology (AT), barriers, engineering, facilitators, instructor, laboratory, STEM education, science, students with disabilities and technology. Twenty-two of the 233 publications that met the review's inclusion criteria were examined. Barriers and facilitators were grouped based on the international classification of functioning, disability and health framework (ICF). None of the studies directly found barriers or facilitators to SwD-P in science or engineering laboratories within postsecondary environments. The literature is not clear on the issues specifically related to SwD-P. Given these findings, further research (e.g., surveys or interviews) should be conducted to identify more details to obtain more substantial information on the barriers that may prevent SwD-P from fully participating in S&E instructional laboratories. Implications for Rehabilitation Students with disabilities remain underrepresented going into STEM careers. A need exist to help uncover barriers students with disabilities encounter in STEM laboratory. Environments. Accommodations and strategies that facilitate participation in STEM laboratory environments are promising for students with disabilities.

The Altitude Laboratory for the Test of Aircraft Engines

NASA Technical Reports Server (NTRS)

Dickinson, H C; Boutell, H G

1920-01-01

Report presents descriptions, schematics, and photographs of the altitude laboratory for the testing of aircraft engines constructed at the Bureau of Standards for the National Advisory Committee for Aeronautics.

Ongoing hepatitis A among men who have sex with men (MSM) linked to outbreaks in Europe in Tel Aviv area, Israel, December 2016 - June 2017.

PubMed

Gozlan, Yael; Bar-Or, Itay; Rakovsky, Aviya; Savion, Michal; Amitai, Ziva; Sheffer, Rivka; Ceder, Noa; Anis, Emilia; Grotto, Itamar; Mendelson, Ella; Mor, Orna

2017-07-20

Between December 2016 and June 2017, 19 Hepatitis A virus (HAV)-positive cases, 17 of which were among men who have sex with men (MSM) were identified in the Tel Aviv area. Seven of the 15 sewage samples collected between January and June 2017 were also HAV-positive. All sequences clustered with two of the three strains identified in the current European HAV outbreak. We demonstrate that despite an efficient vaccination programme, HAV can still be transmitted to an unvaccinated high-risk population. This article is copyright of The Authors, 2017.

Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investigation.

PubMed

Bazzicalupi, Carla; Ferraroni, Marta; Papi, Francesco; Massai, Lara; Bertrand, Benoît; Messori, Luigi; Gratteri, Paola; Casini, Angela

2016-03-18

The dicarbene gold(I) complex [Au(9-methylcaffein-8-ylidene)2 ]BF4 is an exceptional organometallic compound of profound interest as a prospective anticancer agent. This gold(I) complex was previously reported to be highly cytotoxic toward various cancer cell lines in vitro and behaves as a selective G-quadruplex stabilizer. Interactions of the gold complex with various telomeric DNA models have been analyzed by a combined ESI MS and X-ray diffraction (XRD) approach. ESI MS measurements confirmed formation of stable adducts between the intact gold(I) complex and Tel 23 DNA sequence. The crystal structure of the adduct formed between [Au(9-methylcaffein-8-ylidene)2 ](+) and Tel 23 DNA G-quadruplex was solved. Tel 23 maintains a characteristic propeller conformation while binding three gold(I) dicarbene moieties at two distinct sites. Stacking interactions appear to drive noncovalent binding of the gold(I) complex. The structural basis for tight gold(I) complex/G-quadruplex recognition and its selectivity are described. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pfeffer, H.; Saewert, G.

This paper reports on a 6 kV modulator built and installed at Fermilab to drive the electron gun anode for the Tevatron Electron Lens (TEL). The TEL was built with the intention of shifting the individual (anti)proton bunch tunes to even out the tune spread among all 36 bunches with the desire of improving Tevatron integrated luminosity. This modulator is essentially a 6 kV arbitrary waveform generator that enables the TEL to define the electron beam intensity on a bunch-by-bunch basis. A voltage waveform is constructed having a 7 μs duration that corresponds to the tune shift requirements of amore » 12-bunch (anti)proton beam pulse train. This waveform is played out for any one or all three bunch trains in the Tevatron. The programmed waveform voltages transition to different levels at time intervals corresponding to the 395 ns bunch spacing. In addition, complex voltage waveforms can be played out at a sustained rate of 143 kHz over the full 6 kV output range. This paper describes the novel design of the inductive adder topology employing five transformers. It describes the design aspects that minimize switching losses for this multi-kilovolt, high repetition rate and high duty factor application.« less

A qualitative study investigating the use of a mobile phone short message service designed to improve HIV adherence and retention in care in Canada (WelTel BC1).

PubMed

Smillie, Kirsten; Van Borek, Natasha; Abaki, Joshua; Pick, Neora; Maan, Evelyn J; Friesen, Karen; Graham, Rebecca; Levine, Sarah; van der Kop, Mia L; Lester, Richard T; Murray, Melanie

2014-01-01

Patient engagement in care and adherence to medication are critical to achieving the full benefits of antiretroviral therapy (ART) among people with HIV infection. A randomized controlled trial in Kenya, WelTelKenya1, showed that an interactive mobile phone text-messaging intervention can improve adherence and viral load suppression. We conducted a pilot study to adapt the WelTel intervention for HIV-infected clients (n = 25) at an HIV clinic in Vancouver, British Columbia. Between April and June 2012, we recruited five participants from five groups: youth (14-24 years), mature (≥50 years), English as a second language, remote (≥3 hours travel time to clinic), and nonsuppressed (CD4+ T cell count <200 cells/mm(3) and viral load ≥250 copies/mL on two consecutive occasions). Participants described the intervention as a useful way to communicate with health care providers, thus increasing the ability to access services, report side effects, and attend appointments. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding

PubMed Central

Ray, Sujay; Bandaria, Jigar N.; Qureshi, Mohammad H.; Yildiz, Ahmet; Balci, Hamza

2014-01-01

Human telomeres terminate with a single-stranded 3′ G overhang, which can be recognized as a DNA damage site by replication protein A (RPA). The protection of telomeres (POT1)/POT1-interacting protein 1 (TPP1) heterodimer binds specifically to single-stranded telomeric DNA (ssTEL) and protects G overhangs against RPA binding. The G overhang spontaneously folds into various G-quadruplex (GQ) conformations. It remains unclear whether GQ formation affects the ability of POT1/TPP1 to compete against RPA to access ssTEL. Using single-molecule Förster resonance energy transfer, we showed that POT1 stably loads to a minimal DNA sequence adjacent to a folded GQ. At 150 mM K+, POT1 loading unfolds the antiparallel GQ, as the parallel conformation remains folded. POT1/TPP1 loading blocks RPA’s access to both folded and unfolded telomeres by two orders of magnitude. This protection is not observed at 150 mM Na+, in which ssTEL forms only a less-stable antiparallel GQ. These results suggest that GQ formation of telomeric overhangs may contribute to suppression of DNA damage signals. PMID:24516170

New Laboratory Course for Senior-Level Chemical Engineering Students

ERIC Educational Resources Information Center

Aronson, Mark T.; Deitcher, Robert W.; Xi, Yuanzhou; Davis, Robert J.

2009-01-01

A new laboratory course has been developed at the University of Virginia for senior- level chemical engineering students. The new course is based on three 4-week long experiments in bioprocess engineering, energy conversion and catalysis, and polymer synthesis and characterization. The emphasis is on the integration of process steps and the…

1. Photographic copy of original engineering drawing for Test Stand ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photographic copy of original engineering drawing for Test Stand 'C.' California Institute of Technology, Jet Propulsion Laboratory, Plant Engineering 'New Test Stand Plan -- Edwards Test Station' drawing no. E18/2-3, 18 January 1957. - Jet Propulsion Laboratory Edwards Facility, Test Stand C, Edwards Air Force Base, Boron, Kern County, CA

Annotated bibliography of Software Engineering Laboratory (SEL) literature

NASA Technical Reports Server (NTRS)

Card, D.

1982-01-01

An annotated bibliography of technical papers, documents, and memorandums produced by or related to the Software Engineering Laboratory is presented. More than 75 publications are summarized. An index of these publications by subject is also included. These publications cover many areas of software engineering and range from research reports to software documentation.

Reengineering Electrical Engineering Undergraduate Laboratories at Escola Politecnica, University of Sao Paulo.

ERIC Educational Resources Information Center

Seabra, Antonio C.; Consonni, Denise

Brazilian engineering schools are under a strict program to reengineer their courses with the financial support of the federal agencies. At the electronic engineering department at the University of Sao Paulo, this process started by modifying the Basic Electricity and Electronic Laboratories. This paper describes the new structure of these labs…

An Evaluation of the Pavement Condition Index Prediction Model for Rigid Airfield Pavements

DTIC Science & Technology

1982-09-01

UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGO(I*%A Data Entotoi) The United States Army Corps of Engineers, Construction Engineering Research Laboratory...Condition . . . 31 Pavement Design/ Construction ....... . 82 Aircraft Traffic ........ .............. 82 Climate Conditions ........ ............. 84...PATTERSON AFB . . . . . . . . . . . . . . . . . . . . . . . . . 155 C. DATA OBTAINED FROM THE CONSTRUCTION ENGINEERING RESEARCH LABORATORY. .. .. 168 D

Stationary Engineering Laboratory--2. Teacher's Guide.

ERIC Educational Resources Information Center

Steingress, Frederick M.; Frost, Harold J.

The Stationary Engineering Laboratory Manual 2 Teacher's Guide was designed as an aid to the instructors of vocational-technical high school students who have received instruction in the basics of stationary engineering. The course of study was developed for students who will be operating a live plant and who will be responsible for supplying…

Operationalizing mHealth to improve patient care: a qualitative implementation science evaluation of the WelTel texting intervention in Canada and Kenya.

PubMed

Bardosh, Kevin Louis; Murray, Melanie; Khaemba, Antony M; Smillie, Kirsten; Lester, Richard

2017-12-06

Mobile health (mHealth) applications have proliferated across the globe with much enthusiasm, although few have reached scale and shown public health impact. In this study, we explored how different contextual factors influenced the implementation, effectiveness and potential for scale-up of WelTel, an easy-to-use and evidence-based mHealth intervention. WelTel uses two-way SMS communication to improve patient adherence to medication and engagement in care, and has been developed and tested in Canada and Kenya. We used a comparative qualitative case study design, which drew on 32 key informant interviews, conducted in 2016, with stakeholders involved in six WelTel projects. Our research was guided by the Consolidated Framework for Implementation Research (CFIR), a meta-theoretical framework, and our analysis relied on a modified approach to grounded theory, which allowed us to compare findings across these projects. We found that WelTel had positive influences on the "culture of care" at local clinics and hospitals in Canada and Kenya, many of which stretched beyond the immediate patient-client relationship to influence wider organizational systems. However, these were mediated by clinician norms and practices, the availability of local champion staff, the receptivity and capacity of local management, and the particular characteristics of the technology platform, including the ability for adaptation and co-design. We also found that scale-up was influenced by different forms of data and evidence, which played important roles in legitimization and partnership building. Even with robust research evidence, scale-up was viewed as a precarious and uncertain process, embedded within the wider politics and financing of Canadian and Kenyan health systems. Challenges included juggling different interests, determining appropriate financing pathways, maintaining network growth, and "packaging" the intervention for impact and relevance. Our comparative case study, of a unique transnational mobile health research network, revealed that moving from mHealth pilots to scale is a difficult, context-specific process that couples social and technological innovation. Fostering new organizational partnerships and ways of learning are paramount, as mHealth platforms straddle the world of research, industry and public health. Partnerships need to avoid the perils of the technological fix, and engage the structural barriers that mediate people's health and access to services.

Burner Rig Laboratory

NASA Image and Video Library

2015-05-12

The Fuel Burner Rig is a test laboratory at NASA Glenn, which subjects new jet engine materials, treated with protective coatings, to the hostile, high temperature, high velocity environment found inside aircraft turbine engines. These samples face 200-mile per hour flames to simulate the temperatures of aircraft engines in flight. The rig can also simulate aircraft carrier and dusty desert operations where salt and sand can greatly reduce engine life and performance.

ZAP! Adapted: Incorporating design in the introductory electromagnetism lab

NASA Astrophysics Data System (ADS)

McNeil, J. A.

2002-04-01

In the last decade the Accreditation Board of Engineering and Technology(ABET) significantly reformed the criteria by which engineering programs are accredited. The new criteria are called Engineering Criteria 2000 (EC2000). Not surprisingly, engineering design constitutes an essential component of these criteria. The Engineering Physics program at the Colorado School of Mines (CSM) underwent an ABET general review and site visit in the fall of 2000. In preparation for this review and as part of a campus-wide curriculum reform the Physics Department was challenged to include elements of design in its introductory laboratories. As part of the background research for this reform, several laboratory programs were reviewed including traditional and studio modes as well as a course used by Cal Tech and MIT called "ZAP!" which incorporates design activities well-aligned with the EC2000 criteria but in a nontraditional delivery mode. CSM has adapted several ZAP! experiments to a traditional laboratory format while attempting to preserve significant design experiences. The new laboratory forms an important component of the reformed course which attempts to respect the psychological principles of learner-based education. This talk reviews the reformed introductory electromagnetism course and how the laboratories are integrated into the pedagogy along with design activities. In their new form the laboratories can be readily adopted by physics departments using traditional delivery formats.

An Interdisciplinary Laboratory to Teach Experimentation. Final Report.

ERIC Educational Resources Information Center

Schenck, Hilbert, Jr.

The author views the primary purpose of the modern engineering laboratory as teaching the student how to experiment. An attempt is made to update the engineering laboratory and make it generally meaningful for all students, whether headed for graduate school or an industrial job. The intent is to broaden the experimental picture so that students…

25. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

25. PHOTOCOPY OF PLAN DRAWING. Quartermaster Research and Development Laboratory, Natick, Mass. Climatic Building, First Floor Plan, Refrigeration and Engineering. Drawing No. 35-07-01, Sheet 52 of 72, 1952. (Source: NRDEC). - Natick Research & Development Laboratories, Climatic Chambers Building, U.S. Army Natick Research, Development & Engineering Center (NRDEC), Natick, Middlesex County, MA

Combustion and Energy Transfer Experiments: A Laboratory Model for Linking Core Concepts across the Science Curriculum

ERIC Educational Resources Information Center

Barreto, Jose C.; Dubetz, Terry A.; Schmidt, Diane L.; Isern, Sharon; Beatty, Thomas; Brown, David W.; Gillman, Edward; Alberte, Randall S.; Egiebor, Nosa O.

2007-01-01

Core concepts can be integrated throughout lower-division science and engineering courses by using a series of related, cross-referenced laboratory experiments. Starting with butane combustion in chemistry, the authors expanded the underlying core concepts of energy transfer into laboratories designed for biology, physics, and engineering. This…

The Advancement in Using Remote Laboratories in Electrical Engineering Education: A Review

ERIC Educational Resources Information Center

Almarshoud, A. F.

2011-01-01

The rapid development in Internet technology and its big popularity has led some universities around the world to incorporate web-based learning in some of their programmes. The present paper introduces a comprehensive survey of the publications about using remote laboratories in electrical engineering education. Remote laboratories are web-based,…

Sandia Laboratories technical capabilities: engineering analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lundergan, C. D.

1975-12-01

This report characterizes the engineering analysis capabilities at Sandia Laboratories. Selected applications of these capabilities are presented to illustrate the extent to which they can be applied in research and development programs. (auth)

ORNL Fuels, Engines, and Emissions Research Center (FEERC)

ScienceCinema

None

2018-02-13

This video highlights the Vehicle Research Laboratory's capabilities at the Fuels, Engines, and Emissions Research Center (FEERC). FEERC is a Department of Energy user facility located at the Oak Ridge National Laboratory.

Pretreatment Engineering Platform Phase 1 Final Test Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kurath, Dean E.; Hanson, Brady D.; Minette, Michael J.

2009-12-23

Pacific Northwest National Laboratory (PNNL) was tasked by Bechtel National Inc. (BNI) on the River Protection Project, Hanford Tank Waste Treatment and Immobilization Plant (RPP-WTP) project to conduct testing to demonstrate the performance of the WTP Pretreatment Facility (PTF) leaching and ultrafiltration processes at an engineering-scale. In addition to the demonstration, the testing was to address specific technical issues identified in Issue Response Plan for Implementation of External Flowsheet Review Team (EFRT) Recommendations - M12, Undemonstrated Leaching Processes.( ) Testing was conducted in a 1/4.5-scale mock-up of the PTF ultrafiltration system, the Pretreatment Engineering Platform (PEP). Parallel laboratory testing wasmore » conducted in various PNNL laboratories to allow direct comparison of process performance at an engineering-scale and a laboratory-scale. This report presents and discusses the results of those tests.« less

Ranking protective coatings: Laboratory vs. field experience

NASA Astrophysics Data System (ADS)

Conner, Jeffrey A.; Connor, William B.

1994-12-01

Environmentally protective coatings are used on a wide range of gas turbine components for survival in the harsh operating conditions of engines. A host of coatings are commercially available to protect hot-section components, ranging from simple aluminides to designer metallic overlays and ceramic thermal barrier coatings. A variety of coating-application processes are available, and they range from simple pack cementation processing to complex physical vapor deposition, which requires multimillion dollar facilities. Detailed databases are available for most coatings and coating/process combinations for a range of laboratory tests. Still, the analysis of components actually used in engines often yields surprises when compared against predicted coating behavior from laboratory testing. This paper highlights recent work to develop new laboratory tests that better simulate engine environments. Comparison of in-flight coating performance as well as industrial and factory engine testing on a range of hardware is presented along with laboratory predictions from standard testing and from recently developed cyclic burner-rig testing.

Mobile Text Messaging to Improve Medication Adherence and Viral Load in a Vulnerable Canadian Population Living With Human Immunodeficiency Virus: A Repeated Measures Study

PubMed Central

King, Elizabeth; Kinvig, Karen; Steif, Jonathan; Qiu, Annie Q; Maan, Evelyn J; Albert, Arianne YK; Pick, Neora; Alimenti, Ariane; Kestler, Mary H; Money, Deborah M; Lester, Richard T

2017-01-01

Background Combination antiretroviral therapy (cART) as treatment for human immunodeficiency virus (HIV) infection is effective and available, but poor medication adherence limits benefits, particularly in vulnerable populations. In a Kenyan randomized controlled trial, a weekly text-messaging intervention (WelTel) improved cART adherence and HIV viral load (VL). Despite growing evidence for short message service (SMS) text-message interventions in HIV care, there is a paucity of data utilizing these interventions in marginalized or female cohorts. Objective This study was undertaken to assess whether the standardized WelTel SMS text-message intervention applied to a vulnerable, predominantly female, population improved cART adherence and VL. Methods We conducted a repeated measures study of the WelTel intervention in high-risk HIV-positive persons by measuring change in VL, CD4 count, and self-reported adherence 12 months before and 12 months after the WelTel intervention was introduced. Inclusion criteria included VL ≥200 copies/mL, indication for treatment, and meeting vulnerability criteria. Participants were given a mobile phone with unlimited texting (where required), and weekly check-in text messages were sent for one year from the WelTel computer platform. Clinical data were collected for control and intervention years. Participants were followed by a multidisciplinary team in a clinical setting. Outcomes were assessed using Wilcoxon signed ranks tests for change in CD4 and VL from control year to study end and mixed-effects logistic regressions for change in cART adherence and appointment attendance. A secondary analysis was conducted to assess the effect of response rate on the outcome by modeling final log10 VL by number of responses while controlling for mean log10 VL in the control year. Results Eighty-five participants enrolled in the study, but 5 withdrew (final N=80). Participants were predominantly female (90%, 72/80) with a variety of vulnerabilities. Mean VL decreased from 1098 copies/mL in the control year to 439 copies/mL at study end (P=.004). Adherence to cART significantly improved (OR 1.14, IQR 1.10-1.18; P<.001), whereas appointment attendance decreased slightly with the intervention (OR 0.81, IQR 0.67-0.99; P=.03). A response was received for 46.57% (1753/3764) of messages sent and 9.62% (362/3764) of text messages sent were replied to with a problem. An outcome analysis examining relationship between reply rate and VL did not meet statistical significance (P=.07), but may be worthy of investigating further in a larger study. Conclusions WelTel may be an effective tool for improving cART adherence and reducing VLs among high-risk, vulnerable HIV-positive persons. Trial Registration Clinicaltrials.gov NCT02603536; https://clinicaltrials.gov/ct2/show/NCT02603536 (Archived by WebCite at http://www.webcitation.org/6qK57zCwv) PMID:28572079

Wright R–2600–8 Engine in the Engine Propeller Research Building

NASA Image and Video Library

1943-03-21

A Wright Aeronautical R–2600 Cyclone piston engine installed in the Engine Propeller Research Building, or Prop House, at the National Advisory Committee for Aeronautics (NACA) Aircraft Engine Research Laboratory. The R–2600 was among the most powerful engines that emerged during World War II. The engine, which was developed for commercial applications in 1939, was used to power the North American B–25 bomber and several other midsize military aircraft. The higher altitudes required by the military caused problems with the engine's cooling and fuel systems. The military requested that the Aircraft Engine Research Laboratory analyze the performance of the R–2600, improve its cooling system, and reduce engine knock. The NACA researchers subjected the engine to numerous tests in its Prop House. The R–2600 was the subject of the laboratory's first technical report, which was written by members of the Fuels and Lubricants Division. The Prop House contained soundproof test cells in which piston engines and propellers were mounted and operated at high powers. Electrically driven fans drew air through ducts to create a stream of cooling air over the engines. Researchers tested the performance of fuels, turbochargers, water-injection and cooling systems here during World War II. The facility was also investigated a captured German V–I buzz bomb during the war.

High Fidelity Simulation of Atomization in Diesel Engine Sprays

DTIC Science & Technology

2015-09-01

ARL-RP-0555 ● SEP 2015 US Army Research Laboratory High Fidelity Simulation of Atomization in Diesel Engine Sprays by L Bravo...ARL-RP-0555 ● SEP 2015 US Army Research Laboratory High Fidelity Simulation of Atomization in Diesel Engine Sprays by L...Simulation of Atomization in Diesel Engine Sprays 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) L Bravo, CB Ivey, D

Effects of Induction-System Icing on Aircraft-Engine Operating Characteristics

NASA Technical Reports Server (NTRS)

Stevens, Howard C., Jr.

1947-01-01

An investigation was conducted on a multicylinder aircraft engine on a dynamometer stand to determine the effect of induction-system icing on engine operating characteristics and to compare the results with those of a previous laboratory investigation in which only the carburetor and the engine-stage supercharger assembly from the engine were used. The experiments were conducted at simulated glide power, low cruise power, and normal rated power through a range of humidity ratios and air temperatures at approximately sea-level pressure. Induction-system icing was found to occur within approximately the same limits as those established by the previous laboratory investigation after making suitable allowances for the difference in fuel volatility and throttle angles. Rough operation of the engine was experienced when ice caused a marked reduction in the air flow. Photographs of typical ice formations from this investigation indicate close similarity to icing previously observed in the laboratory.

Use of the LITEE Lorn Manufacturing Case Study in a Senior Chemical Engineering Unit Operations Laboratory

ERIC Educational Resources Information Center

Abraham, Nithin Susan; Abulencia, James Patrick

2011-01-01

This study focuses on the effectiveness of incorporating the Laboratory for Innovative Technology and Engineering Education (LITEE) Lorn Manufacturing case into a senior level chemical engineering unit operations course at Manhattan College. The purpose of using the case study is to demonstrate the relevance of ethics to chemical engineering…

1. Photographic copy of engineering drawing showing elevations and sections ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photographic copy of engineering drawing showing elevations and sections of Test Stand 'E' (Building 4259/E-60). California Institute of Technology, Jet Propulsion Laboratory, Plant Engineering 'Solid Propellant Test Stand E-60 - Elevations & Sections,' sheet E60/10, no date. - Jet Propulsion Laboratory Edwards Facility, Test Stand E, Edwards Air Force Base, Boron, Kern County, CA

Lab-on-a-Chip Design-Build Project with a Nanotechnology Component in a Freshman Engineering Course

ERIC Educational Resources Information Center

Allam, Yosef; Tomasko, David L.; Trott, Bruce; Schlosser, Phil; Yang, Yong; Wilson, Tiffany M.; Merrill, John

2008-01-01

A micromanufacturing lab-on-a-chip project with a nanotechnology component was introduced as an alternate laboratory in the required first-year engineering curriculum at The Ohio State University. Nanotechnology is introduced in related reading and laboratory tours as well as laboratory activities including a quarter-length design, build, and test…

40 CFR Appendix II to Part 1054 - Duty Cycles for Laboratory Testing

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Duty Cycles for Laboratory Testing II.... 1054, App. II Appendix II to Part 1054—Duty Cycles for Laboratory Testing (a) Test handheld engines with the following steady-state duty cycle: G3 mode No. Engine speed a Torque(percent) b Weighting...

LABORATORY AND FIELD AUDITS AS PART OF THE EPA (ENVIRONMENTAL PROTECTION AGENCY) HAZARDOUS WASTE ENGINEERING RESEARCH LABORATORY (HWERL) QUALITY ASSURANCE PROGRAM

EPA Science Inventory

Audits are an important and integral part of the EPA Hazardous Waste Engineering Research Laboratory (HWERL) Quality Assurance (QA) Program. As part of the overall QA program, audits are used to determine contractor compliance with quality assurance plans and to assess the overal...

Using Laboratory Experiments and Circuit Simulation IT Tools in an Undergraduate Course in Analog Electronics

ERIC Educational Resources Information Center

Baltzis, Konstantinos B.; Koukias, Konstantinos D.

2009-01-01

Laboratory-based courses play a significant role in engineering education. Given the role of electronics in engineering and technology, laboratory experiments and circuit simulation IT tools are used in their teaching in several academic institutions. This paper discusses the characteristics and benefits of both methods. The content and structure…

Geo-Cultural Analysis Tool (trademark) (GCAT)

DTIC Science & Technology

2008-03-10

Construction Engineering Research Laboratory (CERL) Champaign, IL Cold Regions Researc and Engineering Laboratory (CRREL) Hanover, NH European...Point B? Time/Day: Mid afternoon, Friday Mosque Leisure Market /Retail Area Entertainment District Departure Point Destination Point Transportation

DOE Office of Scientific and Technical Information (OSTI.GOV)

The U.S. Department of Energy's (DOE) Co-Optimization of Fuels & Engines (Co-Optima) initiative is accelerating the introduction of affordable, scalable, and sustainable fuels and high-efficiency, low-emission engines with a first-of-its-kind effort to simultaneously tackle fuel and engine research and development (R&D). This report summarizes accomplishments in the first year of the project. Co-Optima is conducting concurrent research to identify the fuel properties and engine design characteristics needed to maximize vehicle performance and affordability, while deeply cutting emissions. Nine national laboratories - the National Renewable Energy Laboratory and Argonne, Idaho, Lawrence Berkeley, Lawrence Livermore, Los Alamos, Oak Ridge, Pacific Northwest, andmore » Sandia National Laboratories - are collaborating with industry and academia on this groundbreaking research.« less

The Robert E. Hopkins Center for Optical Design and Engineering

NASA Astrophysics Data System (ADS)

Zavislan, James M.; Brown, Thomas G.

2008-08-01

In 1929, a grant from Eastman Kodak and Bausch and Lomb established The Institute of Optics as the nation's first academic institution devoted to training optical scientists and engineers. The mission was 'to study light in all its phases', and the curriculum was designed to educate students in the fundamentals of optical science and build essential skills in applied optics and optical engineering. Indeed, our historic strength has been a balance between optical science and engineering--we have alumni who are carrying out prize-winning research in optical physics, alumni who are innovative optical engineers, and still other alumni who are leaders in the business community. Faculty who are top-notch optical engineers are an important resource to optical physics research groups -- likewise, teaching and modeling excellent optical science provides a strong underpinning for students on the applied/engineering end of the spectrum. This model -an undergraduate and graduate program that balances fundamental optics, applied optics, and optical engineering- has served us well. The impressive and diverse range of opportunities for our BS graduates has withstood economic cycles, and the students graduate with a healthy dose of practical experience. Undergraduate advisors, with considerable initiative from the program coordinator, are very aggressive in pointing students toward summer research and engineering opportunities. The vast majority of our undergraduate students graduate with at least one summer of experience in a company or a research laboratory. For example, 95% of the class of 2008 spent the summer of 2007 at companies and/or research laboratories: These include Zygo, NRL, Bausch and Lomb, The University of Rochester(The Institute of Optics, Medical Center, and Laboratory for Laser Energetics), QED, ARL Night Vision laboratories, JPL, Kollsman, OptiMax, Northrup Grumman, and at least two other companies. It is an impressive list, and bodes well for the career preparation for these students. While this extracurricular experience is truly world-class, an integrated design experience defined within our academic program is increasingly necessary for those going on to professional careers in engineering. This paper describes the philosophy behind a revision to our undergraduate curriculum that integrates a design experience and describes the engineering laboratory that has been established to make it a reality. The laboratory and design center has been named in honor of Robert E. Hopkins, former director and professor, co-founder of Tropel corporation, and a lifelong devotee to engineering innovation.

Software Engineering Laboratory (SEL) data and information policy

NASA Technical Reports Server (NTRS)

Mcgarry, Frank

1991-01-01

The policies and overall procedures that are used in distributing and in making available products of the Software Engineering Laboratory (SEL) are discussed. The products include project data and measures, project source code, reports, and software tools.

Department of Defense Instrumentation Award.

DTIC Science & Technology

1985-07-01

Office of Scientific Research Prepared by The Electrical Engineering Department and The Laboratory for Plasma and Fusion Energy Studies University of...Electrical Engineering Department Laboratory for Plasma and Fusion Energy Studies University of Maryland College Park, Maryland 20742 Principal Investigator

Study of Scientists and Engineers in DoD Laboratories

DTIC Science & Technology

1982-09-01

LABORATORY PERSONNEL CEILINGS - REPEAL HIGH GRADE CEILINGS AND CREATE DEFENSE S&T SERVICE - ADJUST S&E PAY SCALE TO MEET MARKET COMPETITION - REMOVE...with an June 1980 examination of the dynamics of the S&E labor NSF-80-316 market -- i.e., the flows into and out of science and engineering. National...at all degreeand beyond Science and levels and tight markets at all degree levels inOct, 1980 Engineerinp, most engineering fields. Engineering and

Aerial View of NACA's Lewis Flight Propulsion Research Laboratory

NASA Image and Video Library

1946-05-21

The National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory in Cleveland, Ohio as seen from the west in May 1946. The Cleveland Municipal Airport is located directly behind. The laboratory was built in the early 1940s to resolve problems associated with aircraft engines. The initial campus contained seven principal buildings: the Engine Research Building, hangar, Fuels and Lubricants Building, Administration Building, Engine Propeller Research Building, Altitude Wind Tunnel, and Icing Research Tunnel. These facilities and their associated support structures were located within an area occupying approximately one-third of the NACA’s property. After World War II ended, the NACA began adding new facilities to address different problems associated with the newer, more powerful engines and high speed flight. Between 1946 and 1955, four new world-class test facilities were built: the 8- by 6-Foot Supersonic Wind Tunnel, the Propulsion Systems Laboratory, the Rocket Engine Test Facility, and the 10- by 10-Foot Supersonic Wind Tunnel. These large facilities occupied the remainder of the NACA’s semicircular property. The Lewis laboratory expanded again in the late 1950s and early 1960s as the space program commenced. Lewis purchased additional land in areas adjacent to the original laboratory and acquired a large 9000-acre site located 60 miles to the west in Sandusky, Ohio. The new site became known as Plum Brook Station.

2. Photographic copy of engineering drawing showing mechanical systems in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photographic copy of engineering drawing showing mechanical systems in plan and sections of Test Stand 'E,' including tunnel entrance. California Institute of Technology, Jet Propulsion Laboratory, Plant Engineering 'Bldg. E-60 Mechanical, Solid Propellant Test Stand,' sheet E60/13-4, June 20, 1961. - Jet Propulsion Laboratory Edwards Facility, Test Stand E, Edwards Air Force Base, Boron, Kern County, CA

An Alternative Educational Approach for an Inorganic Chemistry Laboratory Course in Industrial and Chemical Engineering

ERIC Educational Resources Information Center

Garces, Andres; Sanchez-Barba, Luis Fernando

2011-01-01

We describe an alternative educational approach for an inorganic chemistry laboratory module named "Experimentation in Chemistry", which is included in Industrial Engineering and Chemical Engineering courses. The main aims of the new approach were to reduce the high levels of failure and dropout on the module and to make the content match the…

Education and Research Laboratories as a Means of Enhancing the Quality of Professional Engineering Education in Design and Production of Composite Parts

ERIC Educational Resources Information Center

Khaliulin, Valentin I.; Gershtein, Elena M.

2016-01-01

Relevance of this research is determined by quality improvement of professional engineering education. The purpose of this paper is to offer practical recommendations for those interested in establishment of education and research laboratories as a means of enhancing the quality of professional engineering education in design and production of…

Tactical Airspace Integration System Situation Awareness Integration Into the Cockpit: Phase 2

DTIC Science & Technology

2013-03-01

ARL-TR-6371 March 2013 prepared by U.S. Army Research Laboratory Human Research and Engineering Directorate (AMCOM Field...Situation Awareness Integration Into the Cockpit: Phase II Michael Sage Jessee and Anthony Morris Human Research and Engineering Directorate, ARL...prepared by U.S. Army Research Laboratory Human Research and Engineering Directorate (AMCOM Field Element) Bldg 5400, Room C236

Laboratory and Field Investigations of Small Crater Repair Technologies

DTIC Science & Technology

2007-09-01

caps over debris backfill or specially placed or compacted backfill, structural systems to bridge craters, foamed crater backfills, and structural ...Jeb S. Tingle, and Timothy J. McCaffrey Geotechnical and Structures Laboratory U.S. Army Engineer Research and Development Center 3909 Halls Ferry...Engineer Research and Development Center (ERDC), Geotechnical and Structures Laboratory (GSL), Vicksburg, MS. The findings and recommendations presented

Integrating Environmental Management in Chemical Engineering Education by Introducing an Environmental Management System in the Student's Laboratory

ERIC Educational Resources Information Center

Montanes, Maria T.; Palomares, Antonio E.

2008-01-01

In this work we show how specific challenges related to sustainable development can be integrated into chemical engineering education by introducing an environmental management system in the laboratory where the students perform their experimental lessons. It is shown how the system has been developed and implemented in the laboratory, what role…

Fire Support Team Experiment.

DTIC Science & Technology

1984-12-01

December 1984 APPROVED FOR PUBUC RELEASE; DISTRIBUTION UNLIMITED. U_ US ARMY *’ HUMAN ENGINEERING LABORATORY US ARMY BALLISTIC RESEARCH LABORATORY ABERDEEN...INTRODUCTION A. Background In March 1982, the HELBAT ( Human Engineering Laboratory Battalion Artillery Test) Executive Committee agreed that the Ballistic...tactical equipment and its -. human operators. FOSCE mimicked the actions of the platoon forward observers that work for the FIST HQ while the FDS

Personalized drug discovery: HCA approach optimized for rare diseases at Tel Aviv University.

PubMed

Solmesky, Leonardo J; Weil, Miguel

2014-03-01

The Cell screening facility for personalized medicine (CSFPM) at Tel Aviv University in Israel is devoted to screening small molecules libraries for finding new drugs for rare diseases using human cell based models. The main strategy of the facility is based on smartly reducing the size of the compounds collection in similarity clusters and at the same time keeping high diversity of pharmacophores. This strategy allows parallel screening of several patient derived - cells in a personalized screening approach. The tested compounds are repositioned drugs derived from collections of phase III and FDA approved small molecules. In addition, the facility carries screenings using other chemical libraries and toxicological characterizations of nanomaterials.

Massive arrival of desalinated seawater in a regional urban water cycle: A multi-isotope study (B, S, O, H).

PubMed

Kloppmann, W; Negev, Ido; Guttman, Joseph; Goren, Orly; Gavrieli, Ittai; Guerrot, Catherine; Flehoc, Christine; Pettenati, Marie; Burg, Avihu

2018-04-01

"Man-made" or unconventional freshwater, like desalinated seawater or reclaimed effluents, is increasingly introduced into regional water cycles in arid or semi-arid countries. We show that the breakthrough of reverse osmosis-derived freshwater in the largely engineered water cycle of the greater Tel Aviv region (Dan Region) has profoundly changed previous isotope fingerprints. This new component can be traced throughout the system, from the drinking water supply, through sewage, treated effluents, and artificially recharged groundwater at the largest Soil-Aquifer Treatment system in the Middle East (Shafdan) collecting all the Dan region sewage. The arrival of the new water type (desalinated seawater) in 2007 and its predominance since 2010 constitutes an unplanned, large-scale, long-term tracer test and the monitoring of the breakthrough of desalination-specific fingerprints in the aquifer system of Shafdan allowed to get new insights on the water and solute flow and behavior in engineered groundwater systems. Our approach provides an investigation tool for the urban water cycle, allowing estimating the contribution of diverse freshwater sources, and an environmental tracing method for better constraining the long-term behavior and confinement of aquifer systems with managed recharge. Copyright © 2017. Published by Elsevier B.V.

Permeation Tests on Polypropylene Fiber Materials

DTIC Science & Technology

2018-03-16

Engineering at the Naval Research Laboratory (NRL) evaluated polypropylene nanofiber materials for their potential in air filtration to remove toxic......The Center for Bio/Molecular Science and Engineering at the Naval Research Laboratory (NRL) evaluated polypropylene nanofiber materials provided by

Software Engineering Laboratory (SEL) data base reporting software user's guide and system description. Volume 2: Program descriptions

NASA Technical Reports Server (NTRS)

1983-01-01

The structure and functions of each reporting software program for the Software Engineering Laboratory data base are described. Baseline diagrams, module descriptions, and listings of program generation files are included.

OHD/HL - Staff

Science.gov Websites

Laboratory Branches Hydrologic Software Engineering Branch (HSEB) Hydrologic Science and Modeling Branch (HSMB) General Info Publications Documentation Software Standard and Guidelines Contact Us HL Staff resources and services. Staff Directory Chief, Hydrology Laboratory; Chief, Hydrologic Software Engineering

Economic Impact Forecast System (EIFS). Version 2.0. Users Manual. Supplement II. European Economic Impact Forecast System (EEIFS), Phase 1, (FRG/EIFS Pilot Model).

DTIC Science & Technology

1982-05-01

Chmpip. tL : Construction engineering Research Laboratory ; available from NTIS. 1982. 71 p. (Technical report / Construction Engineering Researsh ...AD-Al17 661 CONSTRUCTION ENGINEERING RESEARCH LAB (ARMY) CHAMPAIGN IL F/G 5/3 ECONOMIC IMPACT FORECAST SYSTEM (EIFS). VERSION 2.0. USERS MANU--ETC(u...CONSTRUCTION ENGINEERING RESEARCH LABORATORY 4A762720A896-C-004 P.O. BOX 4005, CHAMPAIGN, IL 61820 I. CONTROLLING OFFICE NAME AND ADDRESS It. REPORT

ISO completes its observations of the Universe by infrared light

NASA Astrophysics Data System (ADS)

1998-04-01

At 07:00 on 8 April 1998, engineers at ESA's ground station at Villafranca near Madrid reported that ISO's telescope was beginning to warm up, above its nominal operating temperature close to absolute zero. This was the sign that ISO had exhausted the superfluid helium used to achieve the very low temperatures necessary for infrared astronomy. Observations ceased at 23h07 when the temperature of the instruments had risen above -269°C. At that time, ISO was observing the galaxy NGC 1808 with the camera (ISOCAM) for Prof. J. Hough (UK). The astronomers then handed ISO over to the engineering team for check-outs and decommissioning. The spacecraft will be switched off in about 28 days' time. Infrared rays come from cool places in the sky, and ISO would have been dazzled by its own heat unless its optical system were extremely cold. At its launch in November 1995, ISO carried a supply of 2000 litres of superfluid helium, which boils at -271 degrees C. Slow venting of the helium into space maintained the low temperature of the optical system. How did ISO achieve its extended life? Three months came from a prudent safety margin in the engineering calculations of the rate of loss of helium. Two months were the result of favourable circumstances in the launch campaign at Kourou in French Guiana. During a technical check of the Ariane 44P launcher, ISO's engineers seized the chance to recharge the helium, and the quick launch that followed meant that the outer parts of the cryogenic system of the spacecraft had little time to warm up in Kourou's tropical climate. Finally, the daily loss of helium turned out to be 17 less than expected, at the lower end of a range of possibilities considered by the engineers. That gave ISO an estimated five months of additional life. The date for the helium to run out remained somewhat uncertain, and astronomers and engineers have been alert to the possibility of its exhaustion for the past few weeks. The huge bonus to astronomers, from ISO's long operating life, is only one of their reasons to be grateful for the highly successful engineering and operations of ISO. The pointing accuracy of ISO's telescope was ten times better than required by the specification, and its jitter was one-fifth of what would have been considered tolerable. Smooth, well-planned operations were extended on a daily basis by a US ground station supporting ESA's Villafranca station. ISO was observing selected targets in the sky for 90-95 of the time available. Even in between the planned observations a "serendipity" programme with the ISOPHOT instrument charted cool objects as ISO slewed from one target to the next. Although ISO's observations are now completed, astronomers will be analysing them for years to come, assisted by a team of mission experts who will continue their work at Villafranca and other centres worldwide until 2001. Commenting on the completion of ISO's observational phase, ESA's director of science, Roger Bonnet, says: "We always knew that ISO's helium would run out one day, and we can be grateful that it has lasted for so long. This is a time for celebration, not sorrow, and I congratulate the VILSPA, ESTEC and ESOC staff who have operated so efficiently the spacecraft as well as European industry which developed such an excellent mission and our scientists who built such an outstanding payload . I wish European astronomers as well as their colleagues from the USA and Japan to now fully exploit the image data acquired by ISO". For further information, please contact : ESA Public Relations Division Martin Kessler Tel: +33(0)1.53.69.71.55 ISO Project Scientist Fax: +33(0)1.53.69.76.90 Tel :+34 (9)1.813.1253 e-mail: mkessler @iso.vilspa.esa.es For background information, consult ISO's wwwpages at : isowww.estec.esa.nl

Engines and Innovation: Lewis Laboratory and American Propulsion Technology

NASA Technical Reports Server (NTRS)

Dawson, Virginia Parker

1991-01-01

This book is an institutional history of the NASA Lewis Research Center, located in Cleveland, Ohio, from 1940, when Congress authorized funding for a third laboratory for the National Advisory Committee for Aeronautics, through the 1980s. The history of the laboratory is discussed in relation to the development of American propulsion technology, with particular focus on the transition in the 1940s from the use of piston engines in airplanes to jet propulsion and that from air-breathing engines to rocket technology when the National Aeronautics and Space Administration was established in 1958. The personalities and research philosophies of the people who shaped the history of the laboratory are discussed, as is the relationship of Lewis Research Center to the Case Institute of Technology.

Examining the Real Merits of the Virtual Microscope

NASA Astrophysics Data System (ADS)

Hennessy, Ronan; Meere, Pat; Ho, Timsie; Menuge, Julian; Tyrrell, Shane; Kamber, Balz; Higgs, Bettie; Kelley, Simon

2017-04-01

The Geoscience e-Laboratory (GeoLAB) project is a cooperative digital petrological microscopy technology enhanced learning (TEL) resource development project involving the four main university geoscience teaching centres in Ireland. Collaborating with the Open University (UK), a new digital library of petrographic thin sections has been added to the Virtual Microscope for Earth Sciences (VMfES) online repository. The collection was compiled with a view to introducing high-quality samples to teaching programmes in a manner that hitherto was limited by sample and microscope availability and cost and the temporal limits of laboratory access. The project has proceeded to explore the pedagogical implications of using the Virtual Microscope in teaching programmes. Online assessments and self-guided exercises developed using applications such as Google Forms have been introduced into programmes at each centre, and complimented by tutorial and interactive videos designed to support self-guided learning. The GeoLab project is reporting on the pedagogical implications of providing students with unimpeded access to high-quality petrographic learning resources during the term of semester and in advance of student assessments. Additionally, the project is collating data on the perceptions of both teachers and learners to using online learning media in mineralogy and petrology programmes, and if there are benefits therein to the more traditional styles of petrology and microscopy teaching and learning.

A 6 kV arbitrary waveform generator for the Tevatron Electron Lens

DOE PAGES

Pfeffer, H.; Saewert, G.

2011-11-09

This paper reports on a 6 kV modulator built and installed at Fermilab to drive the electron gun anode for the Tevatron Electron Lens (TEL). The TEL was built with the intention of shifting the individual (anti)proton bunch tunes to even out the tune spread among all 36 bunches with the desire of improving Tevatron integrated luminosity. This modulator is essentially a 6 kV arbitrary waveform generator that enables the TEL to define the electron beam intensity on a bunch-by-bunch basis. A voltage waveform is constructed having a 7 μs duration that corresponds to the tune shift requirements of amore » 12-bunch (anti)proton beam pulse train. This waveform is played out for any one or all three bunch trains in the Tevatron. The programmed waveform voltages transition to different levels at time intervals corresponding to the 395 ns bunch spacing. In addition, complex voltage waveforms can be played out at a sustained rate of 143 kHz over the full 6 kV output range. This paper describes the novel design of the inductive adder topology employing five transformers. It describes the design aspects that minimize switching losses for this multi-kilovolt, high repetition rate and high duty factor application.« less

Indications of stellar prominence oscillations on fast rotating stars: the cases of HK Aqr and PZ Tel

NASA Astrophysics Data System (ADS)

Leitzinger, M.; Odert, P.; Zaqarashvili, T. V.; Greimel, R.; Hanslmeier, A.; Lammer, H.

2016-11-01

We present the analysis of six nights of spectroscopic monitoring of two young and fast rotating late-type stars, namely the dMe star HK Aqr and the dG/dK star PZ Tel. On both stars, we detect absorption features reminiscent of signatures of corotating cool clouds or prominences visible in Hα. Several prominences on HK Aqr show periodic variability in the prominence tracks which follow a sinusoidal motion (indication of prominence oscillations). On PZ Tel, we could not find any periodic variability in the prominence tracks. By fitting sinusoidal functions to the prominence tracks, we derive amplitudes and periods which are similar to those of large-amplitude oscillations seen in solar prominences. In one specific event, we also derive a periodic variation of the prominence track in the Hβ spectral line which shows an anti-phase variation with the one derived for the Hα spectral line. Using these parameters and estimated mass density of a prominence on HK Aqr, we derive a minimum magnetic field strength of ˜2 G. The relatively low strength of the magnetic field is explained by the large height of this stellar prominence (≥ 0.67 stellar radii above the surface).

Tinea capitis outbreak among paediatric refugee population, an evolving healthcare challenge.

PubMed

Mashiah, Jacob; Kutz, Ana; Ben Ami, Ronen; Savion, Mihal; Goldberg, Ilan; Gan Or, Tamar; Zidan, Omri; Sprecher, Eli; Harel, Avikam

2016-09-01

Outbreaks of tinea capitis (TC) represent a major medical and economic burden. Population migrations have become a phenomenon of increasing relevance for medical conditions management. Given the recent massive arrival of immigrants, we sought to determine epidemiologic trends for TC among paediatric populations at the Tel Aviv Medical Center. We conducted a retrospective study of all TC cases diagnosed between 2010 and 2014 in a paediatric dermatology unit of a tertiary medical centre, serving as a referral centre for the paediatric refugee population from the great Tel Aviv area. Epidemiologic, clinical and treatment data including effectiveness and safety were reviewed. In all, 145 children met the inclusion criteria. Trend analyses showed increases in TC rates over the study period. Incidence rates were higher in boys than in girls. Children of African origin had the highest TC incidence rates as compared with other ethnic groups. Trichophyton violaceum and Microsporum audouinii were the predominant causative organisms. Treatment with griseofulvin was satisfactory in all cases. There was a significant increase in TC incidence rates in the Tel Aviv area over the study period. TV and MA were the predominant organisms. These trends may be a result of poor living conditions and crowded school premises. © 2016 Blackwell Verlag GmbH.

Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13.

PubMed

Tseng, Shun-Fu; Shen, Zih-Jie; Tsai, Hung-Ji; Lin, Yi-Hsuan; Teng, Shu-Chun

2009-06-01

Budding yeast telomerase is mainly activated by Tel1/Mec1 (yeast ATM/ATR) on Cdc13 from late S to G2 phase of the cell cycle. Here, we demonstrated that the telomerase-recruitment domain of Cdc13 is also phosphorylated by Cdk1 at the same cell cycle stage as the Tel1/Mec1-dependent regulation. Phosphor-specific gel analysis demonstrated that Cdk1 phosphorylates residues 308 and 336 of Cdc13. The residue T308 of Cdc13 is critical for efficient Mec1-mediated S306 phosphorylation in vitro. Phenotypic analysis in vivo revealed that the mutations in the Cdc13 S/TP motifs phosphorylated by Cdk1 caused cell cycle delay and telomere shortening and these phenotypes could be partially restored by the replacement with a negative charge residue. In the absence of Ku or Tel1, Cdk1-mediated phosphorylation of Cdc13 showed no effect on telomere length maintenance. Moreover, this Cdk1-mediated phosphorylation was required to promote the regular turnover of Cdc13. Together these results demonstrate that Cdk1 phosphorylates the telomerase recruitment domain of Cdc13, thereby preserves optimal function and expression level of Cdc13 for precise telomere replication and cell cycle progression.

Symmetry based assembly of a 2 dimensional protein lattice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poulos, Sandra; Agah, Sayeh; Jallah, Nikardi

2017-04-18

The design of proteins that self-assemble into higher order architectures is of great interest due to their potential application in nanotechnology. Specifically, the self-assembly of proteins into ordered lattices is of special interest to the field of structural biology. Here we designed a 2 dimensional (2D) protein lattice using a fusion of a tandem repeat of three TelSAM domains (TTT) to the Ferric uptake regulator (FUR) domain. We determined the structure of the designed (TTT-FUR) fusion protein to 2.3 Å by X-ray crystallographic methods. In agreement with the design, a 2D lattice composed of TelSAM fibers interdigitated by the FURmore » domain was observed. As expected, the fusion of a tandem repeat of three TelSAM domains formed 21 screw axis, and the self-assembly of the ordered oligomer was under pH control. We demonstrated that the fusion of TTT to a domain having a 2-fold symmetry, such as the FUR domain, can produce an ordered 2D lattice. The TTT-FUR system combines features from the rotational symmetry matching approach with the oligomer driven crystallization method. This TTT-FUR fusion was amenable to X-ray crystallographic methods, and is a promising crystallization chaperone.« less

Technical Capabilities of the National Vehicle and Fuel Emissions Laboratory (NVFEL)

EPA Pesticide Factsheets

National Vehicle and Fuel Emissions Laboratory (NVFEL) is a state-of-the-art test facility that conducts a wide range of emissions testing and analysis for EPA’s motor vehicle, heavy-duty engine, and nonroad engine programs.

Advanced Engineering Fibers.

ERIC Educational Resources Information Center

Edie, Dan D.; Dunham, Michael G.

1987-01-01

Describes Clemson University's Advanced Engineered Fibers Laboratory, which was established to provide national leadership and expertise in developing the processing equipment and advance fibers necessary for the chemical, fiber, and textile industries to enter the composite materials market. Discusses some of the laboratory's activities in…

32 CFR 555.6 - Authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... OF ENGINEERS, RESEARCH AND DEVELOPMENT, LABORATORY RESEARCH AND DEVELOPMENT AND TESTS, WORK FOR OTHERS § 555.6 Authority. The following delegations of authority to perform research and development and tests apply. (a) Major Corps of Engineers Research and Development Laboratories. The major Corps of...

1. Photographic copy of engineering drawing showing structure of Test ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photographic copy of engineering drawing showing structure of Test Stand 'B' (4215/E-16), also known as the 'Short Snorter.' California Institute of Technology, Jet Propulsion Laboratory, Plant Engineering 'Structural Addition - Bldg. E-12, Edwards Test Station,' drawing no. E12/1-1, 8 August 1957. - Jet Propulsion Laboratory Edwards Facility, Test Stand B, Edwards Air Force Base, Boron, Kern County, CA

Department of Defense Laboratory Civilian Science and Engineering Workforce - 2013

DTIC Science & Technology

2013-10-01

was completed by the Institute for Defense Analysis (IDA) in 20091 with an update prepared by the Defense Laboratories Office (DLO) in 2011. By...demographics will emerge giving decision- and policy-makers greater clarity about the impacts of budgets and macro scale policies on this important...Physiology 819 Environmental Engineering 1382 Food Technology 414 Entomology 830 Mechanical Engineering 1384 Textile Technology 415 Toxicology 840

Computational and Genomic Analysis of Mycobacteriophage: A Longitudinal Study of Technology Engineered Biology Courses That Implemented an Inquiry Based Laboratory Practice Designed to Enhance, Encourage, and Empower Student Learning

ERIC Educational Resources Information Center

Hollowell, Gail P.; Osler, James E.; Hester, April L.

2015-01-01

This paper provides an applied research rational for a longitudinal investigation that involved teaching a "Technology Engineered Science Education Course" via an Interactive Laboratory Based Genomics Curriculum. The Technology st Engineering [TE] methodology was first introduced at the SAPES: South Atlantic Philosophy of Education…

Glossary of Software Engineering Laboratory terms

NASA Technical Reports Server (NTRS)

1983-01-01

A glossary of terms used in the Software Engineering Laboratory (SEL) is given. The terms are defined within the context of the software development environment for flight dynamics at the Goddard Space Flight Center. A concise reference for clarifying the language employed in SEL documents and data collection forms is given. Basic software engineering concepts are explained and standard definitions for use by SEL personnel are established.

Compendium of Administrators of Land Use and Related Programs. Revision

DTIC Science & Technology

1982-09-01

construction engineering research laboratory Army Nation Unitad Stoic«» Army ^ n * Technical Report N-40 (Revised) September 19 82...CONTRACT OR GRANT NUMBER’«) \\ 9. PERFORMING ORGANIZATION NAME AND ADDRESS U.S. ARMY CONSTRUCTION ENGINEERING RESEARCH LABORATORY...Chief of Engineers (OCE), under Project 4A762720A896, "Environmental Quality for Construction and Operation of Military Facilities" Task 04. "Land Use

Nanotechnology Safety Self-Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grogin, Phillip W.

2016-03-29

Nanoparticles are near-atomic scale structures between 1 and 100 nanometers (one billionth of a meter). Engineered nanoparticles are intentionally created and are used in research and development at Sandia National Laboratories (SNL) and Los Alamos National Laboratory (LANL). This course, Nanotechnology Safety Self-Study, presents an overview of the hazards, controls, and uncertainties associated with the use of unbound engineered nanoscale particles (UNP) in a laboratory environment.

A Mixed Learning Approach to Integrating Digital Signal Processing Laboratory Exercises into a Non-Lab Junior Year DSP Course

ERIC Educational Resources Information Center

McPheron, Benjamin D.; Thangaraj, Charles V.; Thomas, Charles R.

2017-01-01

Laboratory courses can be difficult to fit into an engineering program at a liberal arts-focused university, which requires students to be exposed to appropriate breadth, as well as sufficient depth in their engineering education. One possible solution to this issue is to integrate laboratory exercises with lecture in a "studio" format,…

MTR WING, TRA604. A LABORATORY ROOM WITH ITS CABINETS AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

MTR WING, TRA-604. A LABORATORY ROOM WITH ITS CABINETS AND SERVICE STRIP DOWN CENTER OF ROOM. CARD IN LEFT CORNER OF VIEW WAS INSERTED BY INL PHOTOGRAPHER TO COVER AN OBSOLETE SECURITY RESTRICTION PRINTED ON THE ORIGINAL NEGATIVE. INL NEGATIVE NO. 3817. Unknown Photographer, 11/28/1951 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Determining the ion temperature and energy distribution in a lithium-plasma interaction test stand with a retarding field energy analyzer

NASA Astrophysics Data System (ADS)

Christenson, M.; Stemmley, S.; Jung, S.; Mettler, J.; Sang, X.; Martin, D.; Kalathiparambil, K.; Ruzic, D. N.

2017-08-01

The ThermoElectric-driven Liquid-metal plasma-facing Structures (TELS) experiment at the University of Illinois is a gas-puff driven, theta-pinch plasma source that is used as a test stand for off-normal plasma events incident on materials in the edge and divertor regions of a tokamak. The ion temperatures and resulting energy distributions are crucial for understanding how well a TELS pulse can simulate an extreme event in a larger, magnetic confinement device. A retarding field energy analyzer (RFEA) has been constructed for use with such a transient plasma due to its inexpensive and robust nature. The innovation surrounding the use of a control analyzer in conjunction with an actively sampling analyzer is presented and the conditions of RFEA operation are discussed, with results presented demonstrating successful performance under extreme conditions. Such extreme conditions are defined by heat fluxes on the order of 0.8 GW m-2 and on time scales of nearly 200 μs. Measurements from the RFEA indicate two primary features for a typical TELS discharge, following closely with the pre-ionizing coaxial gun discharge characteristics. For the case using the pre-ionization pulse (PiP) and the theta pinch, the measured ion signal showed an ion temperature of 23.3 ± 6.6 eV for the first peak and 17.6 ± 1.9 eV for the second peak. For the case using only the PiP, the measured signal showed an ion temperature of 7.9 ± 1.1 eV for the first peak and 6.6 ± 0.8 eV for the second peak. These differences illustrate the effectiveness of the theta pinch for imparting energy on the ions. This information also highlights the importance of TELS as being one of the few linear pulsed plasma sources whereby moderately energetic ions will strike targets without the need for sample biasing.

Determining the ion temperature and energy distribution in a lithium-plasma interaction test stand with a retarding field energy analyzer.

PubMed

Christenson, M; Stemmley, S; Jung, S; Mettler, J; Sang, X; Martin, D; Kalathiparambil, K; Ruzic, D N

2017-08-01

The ThermoElectric-driven Liquid-metal plasma-facing Structures (TELS) experiment at the University of Illinois is a gas-puff driven, theta-pinch plasma source that is used as a test stand for off-normal plasma events incident on materials in the edge and divertor regions of a tokamak. The ion temperatures and resulting energy distributions are crucial for understanding how well a TELS pulse can simulate an extreme event in a larger, magnetic confinement device. A retarding field energy analyzer (RFEA) has been constructed for use with such a transient plasma due to its inexpensive and robust nature. The innovation surrounding the use of a control analyzer in conjunction with an actively sampling analyzer is presented and the conditions of RFEA operation are discussed, with results presented demonstrating successful performance under extreme conditions. Such extreme conditions are defined by heat fluxes on the order of 0.8 GW m -2 and on time scales of nearly 200 μs. Measurements from the RFEA indicate two primary features for a typical TELS discharge, following closely with the pre-ionizing coaxial gun discharge characteristics. For the case using the pre-ionization pulse (PiP) and the theta pinch, the measured ion signal showed an ion temperature of 23.3 ± 6.6 eV for the first peak and 17.6 ± 1.9 eV for the second peak. For the case using only the PiP, the measured signal showed an ion temperature of 7.9 ± 1.1 eV for the first peak and 6.6 ± 0.8 eV for the second peak. These differences illustrate the effectiveness of the theta pinch for imparting energy on the ions. This information also highlights the importance of TELS as being one of the few linear pulsed plasma sources whereby moderately energetic ions will strike targets without the need for sample biasing.

Supercharger Research at the Aircraft Engine Research Laboratory

NASA Image and Video Library

1944-01-21

A researcher in the Supercharger Research Division at the National Advisory Committee for Aeronautics (NACA) Aircraft Engine Research Laboratory measures the blade thickness on a supercharger. Superchargers were developed at General Electric used to supply additional air to reciprocating engines. The extra air resulted in increased the engine’s performance, particularly at higher altitudes. The Aircraft Engine Research Laboratory had an entire division dedicated to superchargers during World War II. General Electric developed the supercharger in response to a 1917 request from the NACA to develop a device to enhance high-altitude flying. The supercharger pushed larger volumes of air into the engine manifold. The extra oxygen allowed the engine to operate at its optimal sea-level rating even when at high altitudes. Thus, the aircraft could maintain its climb rate, maneuverability and speed as it rose higher into the sky. NACA work on the supercharger ceased after World War II due to the arrival of the turbojet engine. The Supercharger Research Division was disbanded in October 1945 and reconstituted as the Compressor and Turbine Division.

Space Electric Research Test in the Electric Propulsion Laboratory

NASA Image and Video Library

1964-06-21

Technicians prepare the Space Electric Research Test (SERT-I) payload for a test in Tank Number 5 of the Electric Propulsion Laboratory at the National Aeronautics and Space Administration (NASA) Lewis Research Center. Lewis researchers had been studying different methods of electric rocket propulsion since the mid-1950s. Harold Kaufman created the first successful engine, the electron bombardment ion engine, in the early 1960s. These electric engines created and accelerated small particles of propellant material to high exhaust velocities. Electric engines have a very small amount of thrust, but once lofted into orbit by workhorse chemical rockets, they are capable of small, continuous thrust for periods up to several years. The electron bombardment thruster operated at a 90-percent efficiency during testing in the Electric Propulsion Laboratory. The package was rapidly rotated in a vacuum to simulate its behavior in space. The SERT-I mission, launched from Wallops Island, Virginia, was the first flight test of Kaufman’s ion engine. SERT-I had one cesium engine and one mercury engine. The suborbital flight was only 50 minutes in duration but proved that the ion engine could operate in space. The Electric Propulsion Laboratory included two large space simulation chambers, one of which is seen here. Each uses twenty 2.6-foot diameter diffusion pumps, blowers, and roughing pumps to remove the air inside the tank to create the thin atmosphere. A helium refrigeration system simulates the cold temperatures of space.

ArF scanner performance improvement by using track integrated CD optimization

NASA Astrophysics Data System (ADS)

Huang, Jacky; Yu, Shinn-Sheng; Ke, Chih-Ming; Wu, Timothy; Wang, Yu-Hsi; Gau, Tsai-Sheng; Wang, Dennis; Li, Allen; Yang, Wenge; Kaoru, Araki

2006-03-01

In advanced semiconductor processing, shrinking CD is one of the main objectives when moving to the next generation technology. Improving CD uniformity (CDU) with shrinking CD is one of the biggest challenges. From ArF lithography CD error budget analysis, PEB (post exposure bake) contributes more than 40% CD variations. It turns out that hot plate performance such as CD matching and within-plate temperature control play key roles in litho cell wafer per hour (WPH). Traditionally wired or wireless thermal sensor wafers were used to match and optimize hot plates. However, sensor-to-sensor matching and sensor data quality vs. sensor lifetime or sensor thermal history are still unknown. These concerns make sensor wafers more suitable for coarse mean-temperature adjustment. For precise temperature adjustment, especially within-hot-plate temperature uniformity, using CD instead of sensor wafer temperature is a better and more straightforward metrology to calibrate hot plates. In this study, we evaluated TEL clean track integrated optical CD metrology (IM) combined with TEL CD Optimizer (CDO) software to improve 193-nm resist within-wafer and wafer-to-wafer CD uniformity. Within-wafer CD uniformity is mainly affected by the temperature non-uniformity on the PEB hot plate. Based on CD and PEB sensitivity of photo resists, a physical model has been established to control the CD uniformity through fine-tuning PEB temperature settings. CD data collected by track integrated CD metrology was fed into this model, and the adjustment of PEB setting was calculated and executed through track internal APC system. This auto measurement, auto feed forward, auto calibration and auto adjustment system can reduce the engineer key-in error and improve the hot plate calibration cycle time. And this PEB auto calibration system can easily bring hot-plate-to-hot-plate CD matching to within 0.5nm and within-wafer CDU (3σ) to less than 1.5nm.

Description of the NACA Universal Test Engine and Some Test Results

NASA Technical Reports Server (NTRS)

Ware, Marsden

1927-01-01

This report describes the 5-inch bore by 7-inch stroke single cylinder test engine used at the Langley Field Laboratory of the National Advisory Committee for Aeronautics in laboratory research on internal-combustion engine problems and presents some results of tests made therewith. The engine is arranged for variation over wide ranges, of the compression ratio and lift and timing of both inlet and exhaust valves while the engine is in operation. Provision is also made for the connection of a number of auxiliaries. These features tend to make the engine universal in character, and especially suited for the study of certain problems involving change in compression ratio, valve timing, and lift.

The Effect of Material and Side Walls on Hull Deflection during a Blast Event

DTIC Science & Technology

2017-12-13

by Danielle Abell SURVICE Engineering Company 4695 Millennium Dr Belcamp, MD 21017 under contract W911QX-16-D-0014...Laboratory. The views and conclusions contained in this document are those of SURVICE Engineering Company and the US Army Research Laboratory. Citation... Engineering Company 4695 Millennium Dr Belcamp, MD 21017 under contract W911QX-16-D-0014 Approved for public release

TRITIUM LABORATORY, TRA666, INTERIOR. MAIN FLOOR. CONTROL ROOM ENCLOSURE AT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

TRITIUM LABORATORY, TRA-666, INTERIOR. MAIN FLOOR. CONTROL ROOM ENCLOSURE AT CENTER OF VIEW. SIGN ABOVE DOOR SAYS "HYDRAULIC TEST FACILITY CONTROL ROOM." SIGN IN WINDOW SAYS "EATING AREA." "EVACUATION AND EMERGENCY INFORMATION" IS POSTED ON CABINET AT LEFT OF VIEW. INL NEGATIVE NO. HD30-2-3. Mike Crane, Photographer, 6/2001 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Apel - Applied Process Engineering Laboratory

Science.gov Websites

startup and testing Equipment can be quickly connected to building services and effluent systems. A professional, regulated environment for bringing forth new product processes and services. Testing shortens the support Pacific Northwest National Laboratory (PNNL) scientists, engineers, and other professional staff

Taking centre stage...

NASA Astrophysics Data System (ADS)

1998-11-01

HAMLET (Highly Automated Multimedia Light Enhanced Theatre) was the star performance at the recent finals of the `Young Engineer for Britain' competition, held at the Commonwealth Institute in London. This state-of-the-art computer-controlled theatre lighting system won the title `Young Engineers for Britain 1998' for David Kelnar, Jonathan Scott, Ramsay Waller and John Wyllie (all aged 16) from Merchiston Castle School, Edinburgh. HAMLET replaces conventional manually-operated controls with a special computer program, and should find use in the thousands of small theatres, schools and amateur drama productions that operate with limited resources and without specialist expertise. The four students received a £2500 prize between them, along with £2500 for their school, and in addition they were invited to spend a special day with the Royal Engineers. A project designed to improve car locking systems enabled Ian Robinson of Durham University to take the `Working in industry award' worth £1000. He was also given the opportunity of a day at sea with the Royal Navy. Other prizewinners with their projects included: Jun Baba of Bloxham School, Banbury (a cardboard armchair which converts into a desk and chair); Kobika Sritharan and Gemma Hancock, Bancroft's School, Essex (a rain warning system for a washing line); and Alistair Clarke, Sam James and Ruth Jenkins, Bishop of Llandaff High School, Cardiff (a mechanism to open and close the retractable roof of the Millennium Stadium in Cardiff). The two principal national sponsors of the competition, which is organized by the Engineering Council, are Lloyd's Register and GEC. Industrial companies, professional engineering institutions and educational bodies also provided national and regional prizes and support. During this year's finals, various additional activities took place, allowing the students to surf the Internet and navigate individual engineering websites on a network of computers. They also visited the Millennium Dome site, constructing a model of the Dome and designing a range of Dome exhibits from innovative assembly kits. Details of the 1999 competition will be available from the Engineering Council at 10 Maltravers Street, London WC2R 3ER (tel: 0171 240 7891, http://www.engc.org.uk).

Circumstellar Dust in Symbiotic Novae

NASA Astrophysics Data System (ADS)

Jurkic, T.; Kotnik-Karuza, D.

2015-12-01

We present a model of inner dust regions around the cool Mira component of the two symbiotic novae, RR Tel and HM Sge, based on the near-IR photometry, ISO spectra and mid-IR interferometry. The dust properties were determined using the DUSTY code. A compact circumstellar silicate dust shell with inner dust shell temperatures between 900 K and 1300 K and of moderate optical depth can explain all the observations. RR Tel shows the presence of an equatorially enhanced dust density during minimum obscuration. Obscuration events are explained by an increase in optical depth caused by the newly condensed dust. The mass loss rates are significantly higher than in intermediate-period single Miras but in agreement with longer-period O-rich AGB stars.

Airborne infrared video radiometry as a low-cost tool for remote sensing of the environment, two mapping examples from Israel of urban heat islands and mineralogical site

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ben-Dor, E.; Saaroni, H.; Ochana, D.

1996-10-01

In this study we examined the capability of a laboratory infrared video camera for use in remote sensing of the environment. The instrument used, INFRAMETRICS 760, was mounted onboard a Bell 206 helicopter. Under the flight conditions examined, the radiometer proved itself to be very stable and produced high-quality thermal images in a real-time mode. We studied two different environmental aspects, as follows: (1) Urban heat island of the most dense city in Israel, Tel-Aviv- and (2) lithological distribution of a well-known mineralogical site in Israel, Makhtesh Ramon. The radiometer used in both studies was able to produce a temperaturemore » presentation, rather than a gray scale from an altitude of 7,000 and 10,000 feet and at 70 knots air speed. The instrument produced a high-quality set of data in terms of signal-to-noise, stability, temperature accuracy and spatial resolution. In the Tel-Aviv case, the results showed that the urban heat island of the city can be depicted in a very high spatial and thermal resolutions domain and that a significant correlation exists between ground objects and the surrounding air temperature values. Based on the flight results, we could generated an isotherm map of the city that, for the first time, located the urban heat island of the city both in meso- and microscales. In the case of Makhtesh Ramon, we found that under field conditions, the radiometer, coupled with a VIS-CCD camera can provide significant ATI parameters of typical rocks that characterize tile study area. Although more study is planned and suggested based on the current data, it was concluded that the airborne thermal video radiometry, is a promising, inexpensive tool for monitoring the environment on a real-time basis. 10 refs., 5 figs., 1 tab.« less

Expedition 22 Change of Command in the U.S. Laboratory

NASA Image and Video Library

2010-03-17

ISS022-E-100364 (17 March 2010) --- Crew members aboard the International Space Station are pictured in the Destiny laboratory during the ceremony of Changing-of-Command from Expedition 22 to Expedition 23. Pictured from the right are NASA astronauts Jeffrey Williams, Expedition 22 commander; and T.J. Creamer, Expedition 22/23 flight engineer; Russian cosmonauts Oleg Kotov, Expedition 22 flight engineer and Expedition 23 commander; and Maxim Suraev, Expedition 22 flight engineer. Not pictured is Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22/23 flight engineer.

1996 Laboratory directed research and development annual report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meyers, C.E.; Harvey, C.L.; Lopez-Andreas, L.M.

This report summarizes progress from the Laboratory Directed Research and Development (LDRD) program during fiscal year 1996. In addition to a programmatic and financial overview, the report includes progress reports from 259 individual R&D projects in seventeen categories. The general areas of research include: engineered processes and materials; computational and information sciences; microelectronics and photonics; engineering sciences; pulsed power; advanced manufacturing technologies; biomedical engineering; energy and environmental science and technology; advanced information technologies; counterproliferation; advanced transportation; national security technology; electronics technologies; idea exploration and exploitation; production; and science at the interfaces - engineering with atoms.

Ice Crystal Icing Engine Testing in the NASA Glenn Research Center's Propulsion Systems Laboratory (PSL): Altitude Investigation

NASA Technical Reports Server (NTRS)

Oliver, Michael J.

2015-01-01

The National Aeronautics and Space Administration conducted a full scale ice crystal icing turbofan engine test in the NASA Glenn Research Centers Propulsion Systems Laboratory (PSL) Facility in February 2013. Honeywell Engines supplied the test article, an obsolete, unmodified Lycoming ALF502-R5 turbofan engine serial number LF01 that experienced an un-commanded loss of thrust event while operating at certain high altitude ice crystal icing conditions. These known conditions were duplicated in the PSL for this testing.

United States Air Force Summer Research Program -- 1993. Volume 16. Arnold Engineering Development Center. Frank J. Seiler Research Laboratory. Wilford Hall Medical Center

DTIC Science & Technology

1993-12-01

A I 7f t UNITED STATE AIR FORCE SUMMER RESEARCH PROGRAM -- 1993 SUMMER RESEARCH PROGRAM FINAL REPORTS VOLUME 16 ARNOLD ENGINEERING DEVELOPMENT CENTER...FRANK J. SELLER RESEARCH LABORATORY WILFORD HALL MEDICAL CENTER RESEARCH & DEVELOPMENT LABORATORIES 5800 Uplander Way Culver City, CA 90230-6608...National Rd. Vol-Page No: 15-44 Dist Tecumseh High School 8.4 New Carlisle, OH 45344-0000 Barber, Jason Laboratory: AL/CF 1000 10th St. Vol-Page No

Laboratory Directed Research and Development FY-10 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dena Tomchak

2011-03-01

The FY 2010 Laboratory Directed Research and Development (LDRD) Annual Report is a compendium of the diverse research performed to develop and ensure the INL's technical capabilities can support the future DOE missions and national research priorities. LDRD is essential to the INL -- it provides a means for the laboratory to pursue novel scientific and engineering research in areas that are deemed too basic or risky for programmatic investments. This research enhances technical capabilities at the laboratory, providing scientific and engineering staff with opportunities for skill building and partnership development.

Proton-Decay Spectroscopic Studies of the Exotic Nuclides 23Al, 23Si, 22Al and 77Rb

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rowe, Michael William

Aluminum-23 was produced by 40 MeV 3He 2+ bombardments of Mg targets in four experiments at the LBNL 88” Cyclotron. Reaction products were transported via helium-jet to a detection chamber where they were counted using two low-energy particle -identif ication (PI) telescopes. New proton groups were observed with laboratory energies (and intensities relative to the known peak at 838±5 keV) of 246±20 (33±3%) and 556±5 keV (68±5%), respectively. Several possible decay assignments are discussed for the former group. The possibility that it originates from the decay through the isobaric analog state (IAS) and corresponding implications for isospin mixing and themore » proton-capture resonance strength are discussed. The Gamow-TelIer strength function has been deduced from these and several weaker proton transitions; the results are compared with theoretical predictions.« less

A gas-puff-driven theta pinch for plasma-surface interaction studies

NASA Astrophysics Data System (ADS)

Jung, Soonwook; Kesler, Leigh; Yun, Hyun-Ho; Curreli, Davide; Andruczyk, Daniel; Ruzic, David

2012-10-01

DEVeX is a theta pinch device used to investigate fusion-related material interaction such as vapor shielding and ICRF antenna interactions with plasma-pulses in a laboratory setting. The simulator is required to produce high heat-flux plasma enough to induce temperature gradient high enough to study extreme conditions happened in a plasma fusion reactor. In order to achieve it, DEVeX is reconfigured to be combined with gas puff system as gas puffing may reduce heat flux loss resulting from collisions with neutral. A gas puff system as well as a conical gas nozzle is manufactured and several diagnostics including hot wire anemometer and fast ionization gauge are carried out to quantitatively estimate the supersonic flow of gas. Energy deposited on the target for gas puffing and static-filled conditions is measured with thermocouples and its application to TELS, an innovative concept utilizing a thermoelectric-driven liquid metal flow for plasma facing component, is discussed.

Performance demonstration of a single-frequency optically-pumped cesium beam frequency standard for space applications

NASA Astrophysics Data System (ADS)

Lecomte, S.; Haldimann, M.; Ruffieux, R.; Thomann, P.; Berthoud, P.

2017-11-01

Observatoire de Neuchâtel (ON) is developing a compact optically-pumped cesium beam frequency standard in the frame of an ESA-ARTES 5 project. The simplest optical scheme, which is based on a single optical frequency for both preparation and detection processes of atoms, has been chosen to fulfill reliability constraints of space applications. With our laboratory demonstrator operated at 852 nm (D2 line), we have measured a frequency stability of σy=2.74x10-12 τ -1/2, which is compliant with the Galileo requirement. The atomic resonator is fully compliant to be operated with a single diode laser at 894 nm (D1 line). Sensitivity measurements of the clock signal to the microwave power and to the optical pumping power are also presented. Present performance limitations are discussed and further improvements are proposed in order to reach our ultimate frequency stability goal of σy=1x10-12 τ -1/2. The clock driving software is also briefly described.

Teaching Sustainability Analysis in Electrical Engineering Lab Courses

ERIC Educational Resources Information Center

Braun, D.

2010-01-01

Laboratory courses represent an incompletely tapped opportunity to teach sustainability concepts. This work introduces and evaluates a simple strategy used to teach sustainability concepts in electrical engineering laboratory courses. The technique would readily adapt to other disciplines. The paper presents assessment data and a wiki containing…

POLLUTION PREVENTION FOR CLEANER AIR: EPA'S AIR AND ENERGY ENGINEERING RESEARCH LABORATORY

EPA Science Inventory

The article discusses the role of EPA's Air and Energy Engineering Research Laboratory (AEERL) in pollution prevention research for cleaner air. For more than 20 years, AEERL has been conducting research to identify control approaches for the pollutants and sources which contribu...

Radar, Thermal Infrared, and Panchromatic Image Collection and Analysis. Multi-Source Image Analysis.

DTIC Science & Technology

1980-12-01

92626. I DECEMBER 1980 APPROVED FOR PUBLIC RELEASE: DISTRIBUTION UNLIMITED Prepared for U.S. ARMY CORPS OF ENGINEERS ENGINEER TOPOGRAPHIC LABORATORIES J...CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE December 1980 U. S. Army Engineer Topographic Laboratories 13. NUMBER OF PAGES Fort Belvoir...infrared and panchromatic imagery was collected by the Oregon Army National Guard at the Corvallis, Oregon, test site on 13 and 19 August 1980 . Ground f

Human Factors Engineering #2 Crewstation Assessment for the OH-58F Helicopter

DTIC Science & Technology

2013-03-01

1 ARMY RSCH LABORATORY – HRED (HC) HUMAN RSRCH AND ENGRNG DIRCTRT MCOE FIELD ELEMENT RDRL HRM DW C CARSTENS 6450 WAY ST BLDG 2839 RM... Human Factors Engineering #2 Crewstation Assessment for the OH-58F Helicopter by David B. Durbin, Jamison S. Hicks, Michael Sage Jessee...Research Laboratory Aberdeen Proving Ground, MD 21005 ARL-TR-6355 March 2013 Human Factors Engineering #2 Crewstation Assessment for the

eLearning Hands-On: Blending Interactive eLearning with Practical Engineering Laboratory

ERIC Educational Resources Information Center

Kiravu, Cheddi; Yanev, Kamen M.; Tunde, Moses O.; Jeffrey, Anna M.; Schoenian, Dirk; Renner, Ansel

2016-01-01

Purpose: Integrating laboratory work into interactive engineering eLearning contents augments theory with practice while simultaneously ameliorating the apparent theory-practice gap in traditional eLearning. The purpose of this paper is to assess and recommend media that currently fulfil this desirable dual pedagogical goal.…

AEERL (AIR AND ENERGY ENGINEERING RESEARCH LABORATORY) RESEARCH PLAN ON THE GLOBAL CLIMATE EMISSIONS ASSESSMENT AND STABILIZATION PROGRAM

EPA Science Inventory

The paper discusses the Environmental Protection Agency's (EPA) Air and Energy Engineering Research Laboratory (AEERL) research plan for work in the global climate area. The plan, written for discussion with senior scientists and program managers at EPA's Global Climate Change Re...

Women's Experiences in the Engineering Laboratory in Japan

ERIC Educational Resources Information Center

Hosaka, Masako

2014-01-01

This qualitative study aims to examine Japanese women undergraduate engineering students' experiences of interacting with departmental peers of the same year in the laboratory setting by using interview data of 32 final-year students at two modestly selective national universities in Japan. Expectation state theory that explains unequal…

Hadfield poses with MSL FLSS in the Node 2

NASA Image and Video Library

2012-12-23

ISS034-E-010603 (28 Dec. 2012) --- Canadian Space Agency astronaut Chris Hadfield, Expedition 34 flight engineer, poses with a Materials Science Laboratory (MSL) Furnace Launch Support Structure (FLSS) in the Destiny laboratory of the International Space Station. NASA astronaut Tom Marshburn, flight engineer, uses a computer in the background.

Software Engineering Laboratory (SEL). Data base organization and user's guide, revision 1

NASA Technical Reports Server (NTRS)

Lo, P. S.; Wyckoff, D.; Page, J.; Mcgarry, F. E.

1983-01-01

The structure of the Software Engineering Laboratory (SEL) data base is described. It defines each data base file in detail and provides information about how to access and use the data for programmers and other users. Several data base reporting programs are described also.

Glossary of software engineering laboratory terms

NASA Technical Reports Server (NTRS)

1982-01-01

A glossary of terms used in the Software Engineering Laboratory (SEL) is presented. The terms are defined within the context of the software development environment for flight dynamics at Goddard Space Flight Center. A concise reference for clarifying and understanding the language employed in SEL documents and data collection forms is provided.

High-Performance Liquid Chromatography in the Undergraduate Chemical Engineering Laboratory

ERIC Educational Resources Information Center

Frey, Douglas D.; Guo, Hui; Karnik, Nikhila

2013-01-01

This article describes the assembly of a simple, low-cost, high-performance liquid chromatography (HPLC) system and its use in the undergraduate chemical engineering laboratory course to perform simple experiments. By interpreting the results from these experiments students are able to gain significant experience in the general method of…

Extending Engineering Design Graphics Laboratories to Have a CAD/CAM Component: Implementation Issues.

ERIC Educational Resources Information Center

Juricic, Davor; Barr, Ronald E.

1996-01-01

Reports on a project that extended the Engineering Design Graphics curriculum to include instruction and laboratory experience in computer-aided design, analysis, and manufacturing (CAD/CAM). Discusses issues in project implementation, including introduction of finite element analysis to lower-division students, feasibility of classroom prototype…

The Legacy of the 1948 Underseepage and Crevasse Maps, Lower Mississippi River Levees

DTIC Science & Technology

2017-04-01

Julie R. Kelley Geotechnical and Structures Laboratory U.S. Army Engineer Research and Development Center 3909 Halls Ferry Road Vicksburg, MS 39180...and Julie R. Kelley Geotechnical and Structures Laboratory U.S. Army Engineer Research and Development Center 3909 Halls Ferry Road Vicksburg

Software Engineering Laboratory (SEL) data base reporting software user's guide and system description. Volume 1: Introduction and user's guide

NASA Technical Reports Server (NTRS)

1983-01-01

Reporting software programs provide formatted listings and summary reports of the Software Engineering Laboratory (SEL) data base contents. The operating procedures and system information for 18 different reporting software programs are described. Sample output reports from each program are provided.

International Co-Operation in Control Engineering Education Using Online Experiments

ERIC Educational Resources Information Center

Henry, Jim; Schaedel, Herbert M.

2005-01-01

This paper describes the international co-operation experience in teaching control engineering with laboratories being conducted remotely by students via the Internet. This paper describes how the students ran the experiments and their personal experiences with the laboratory. A tool for process identification and controller tuning based on…

An Internet-Based Distributed Laboratory for Interactive Chemical Engineering Education

ERIC Educational Resources Information Center

Guo, Jing; Kettler, David J.; Al-Dahhan, Muthanna

2007-01-01

A common undergraduate chemical engineering experiment has been modified for on-line operation over the Internet. By adopting rapidly changing Internet and object component technologies, we developed a novel approach combining the Internet and regular laboratory equipment. The client-server applications use a Visual Basic and Labtech programming…

Using hub technology to facilitate information system integration in a health-care enterprise.

PubMed

Gendler, S M; Friedman, B A; Henricks, W H

1996-04-01

The deployment and maintenance of multiple point-to-point interfaces between a clinical information system, such as a laboratory information system, and other systems within a healthcare enterprise is expensive and time consuming. Moreover, the demand for such interfaces is increasing as hospitals consolidate and clinical laboratories participate in the development of regional laboratory networks and create host-to-host links with laboratory outreach clients. An interface engine, also called a hub, is an evolving technology that could replace multiple point-to-point interfaces from a laboratory information system with a single interface to the hub, preferably HL7 based. The hub then routes and translates laboratory information to other systems within the enterprise. Changes in application systems in an enterprise where a centralized interface engine has been implemented then amount to thorough analysis, an update of the enterprise's data dictionary, purchase of a single new vendor-supported interface, and table-based parameter changes on the hub. Two other features of an interface engine, support for structured query language and information store-and-forward, will facilitate the development of clinical data repositories and provide flexibility when interacting with other host systems. This article describes the advantages and disadvantages of an interface engine and lists some problems not solved by the technology. Finally, early developmental experience with an interface engine at the University of Michigan Medical Center and the benefits of the project on system integration efforts are described, not the least of which has been the enthusiastic adoption of the HL7 standard for all future interface projects.

Description and Laboratory Tests of a Roots Type Aircraft Engine Supercharger

NASA Technical Reports Server (NTRS)

Ware, Marsden

1926-01-01

This report describes a roots type aircraft engine supercharger and presents the results of some tests made with it at the Langley Field Laboratories of the National Advisory Committee for Aeronautics. The supercharger used in these tests was constructed largely of aluminum, weighed 88 pounds and was arranged to be operated from the rear of a standard aircraft engine at a speed of 1 1/2 engine crankshaft speed. The rotors of the supercharger were cycloidal in form and were 11 inches long and 9 1/2 inches in diameter. The displacement of the supercharger was 0.51 cubic feet of air per revolution of the rotors. The supercharger was tested in the laboratory, independently and in combination with a Liberty-12 aircraft engine, under simulated altitude pressure conditions in order to obtain information on its operation and performance. From these tests it seems evident that the Roots blower compares favorably with other compressor types used as aircraft engine superchargers and that it has several features that make it particularly attractive for such use.

Engineering Technology Education: Bibliography 1989.

ERIC Educational Resources Information Center

Dyrud, Marilyn A., Comp.

1990-01-01

Over 200 references divided into 24 different areas are presented. Topics include administration, aeronautics, architecture, biomedical technology, CAD/CAM, civil engineering, computers, curriculum, electrical/electronics engineering, industrial engineering, industry and employment, instructional technology, laboratories, lasers, liberal studies,…

Motivational project-based laboratory for a common first year electrical engineering course

NASA Astrophysics Data System (ADS)

Nedic, Zorica; Nafalski, Andrew; Machotka, Jan

2010-08-01

Over the past few years many universities worldwide have introduced a common first year for all engineering disciplines. This is despite the opinion of many academics that large classes have negative effects on the learning outcomes of first year students. The University of South Australia is also faced with low motivation amongst engineering students studying non-major courses. In 2006, a project-based laboratory was successfully introduced for first year students enrolled in electrical disciplines, which increased student satisfaction, reduced the attrition rate and improved students' success rate. This paper presents the experiences with the project-based laboratory's implementation in three different projects in the common first year course, Electrical and Energy Systems, where each project aims to increase the motivation of students in one of three disciplines: electrical, mechanical or civil engineering.

Tritium in well waters, streams and atomic lakes in the East Kazakhstan Oblast of the Semipalatinsk Nuclear Test Site.

PubMed

Mitchell, Peter I; Vintró, Luis León; Omarova, Aigul; Burkitbayev, Mukhambetkali; Nápoles, Humberto Jiménez; Priest, Nicholas D

2005-06-01

The concentration of tritium has been determined in well waters, streams and atomic lakes in the Sarzhal, Tel'kem, Balapan and Degelen Mountains areas of the Semipalatinsk Test Site. The data show that levels of tritium in domestic well waters within the settlement of Sarzhal are extremely low at the present time with a median value of 4.4 Bq dm(-3) (95% confidence interval:4.1-4.7 Bq dm(-3)). These levels are only marginally above the background tritium content in surface waters globally. Levels in the atomic craters at Tel'kem 1 and Tel'kem 2 are between one and two orders of magnitude higher, while the level in Lake Balapan is approximately 12,600 Bq dm(-3). Significantly, levels in streams and test-tunnel waters sourced in the Degelen Mountains, the site of approximately 215 underground nuclear tests, are a further order of magnitude higher, being in the range 133,000--235,500 Bq dm(-3). No evidence was adduced which indicates that domestic wells in Sarzhal are contaminated by tritium-rich waters sourced in the Degelen massif, suggesting that the latter are not connected hydrologically to the near-surface groundwater recharging the Sarzhal wells. Annual doses to humans arising from the ingestion of tritium in these well waters are very low at the present time and are of no radiological significance.

Unintentional drinking-water contamination events of unknown origin: surrogate for terrorism preparedness.

PubMed

Winston, Gary; Leventhal, Alex

2008-01-01

Drinking-water is a direct conduit to many human receptors. An intentional attack (e.g. terrorism) on drinking-water systems can shock and disrupt elements of national infrastructures. We report on an unintentional drinking-water contamination event that occurred in Tel Aviv, Israel in July, 2001. Initially of unknown origin, this event involved risk management strategies used by the Ministry of Health for abating a potential public health crisis as might be envisaged of water contamination due to terrorism. In an abrupt event of unknown origin, public health officials need to be responsible for the same level of preparedness and risk communication. This is emphasized by comparison of management strategies between the Tel Aviv event and one of dire consequences that occurred in Camelford, England in 1988. From the onset of the Tel Aviv incident, the public health strategy was to employ the precautionary principle by warning residents of the affected region to not drink tap water, even if boiled. This strategy was in contrast to an earlier crisis that occurred in Camelford, England in 1988. An outcome of this event was heightened awareness that a water crisis can occur in peacetime and not only in association with terrorism. No matter how minor the contamination event or short-term the disruption of delivery of safe drinking-water, psychological, medical and public health impact could be significant.

Process for Generating Engine Fuel Consumption Map: Future Atkinson Engine with Cooled EGR and Cylinder Deactivation

EPA Pesticide Factsheets

This document summarizes the process followed to utilize GT-POWER modeled engine and laboratory engine dyno test data to generate a full engine fuel consumption map which can be used by EPA's ALPHA vehicle simulations.

Engine Propeller Research Building at the Lewis Flight Propulsion Laboratory

NASA Image and Video Library

1955-02-21

The Engine Propeller Research Building, referred to as the Prop House, emits steam from its acoustic silencers at the National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory. In 1942 the Prop House became the first completed test facility at the new NACA laboratory in Cleveland, Ohio. It contained four test cells designed to study large reciprocating engines. After World War II, the facility was modified to study turbojet engines. Two of the test cells were divided into smaller test chambers, resulting in a total of six engine stands. During this period the NACA Lewis Materials and Thermodynamics Division used four of the test cells to investigate jet engines constructed with alloys and other high temperature materials. The researchers operated the engines at higher temperatures to study stress, fatigue, rupture, and thermal shock. The Compressor and Turbine Division utilized another test cell to study a NACA-designed compressor installed on a full-scale engine. This design sought to increase engine thrust by increasing its airflow capacity. The higher stage pressure ratio resulted in a reduction of the number of required compressor stages. The last test cell was used at the time by the Engine Research Division to study the effect of high inlet densities on a jet engine. Within a couple years of this photograph the Prop House was significantly altered again. By 1960 the facility was renamed the Electric Propulsion Research Building to better describe its new role in electric propulsion.

Assessing and Controlling Blast Noise Emission: SARNAM Noise Impact Software

DTIC Science & Technology

2007-12-29

Engineers, Engineer Research and Development Center Jeffery Mifflin U.S. Army Corps of Engineers, Engineer Research and Development Center Kristy A...PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) U.S. Army Engineer Research and Development Center (ERDC) Construction Engineering Research Laboratory...6 Figure 5. OneShot control page

NACA Mechanics in an Allison Engine Training Class

NASA Image and Video Library

1943-10-21

The Allison Engine Company's A.G. Covell instructs mechanics from various divisions at the National Advisory Committee for Aeronautics (NACA) Aircraft Engine Research Laboratory on the operation of the Allison Basic Engine. The military had asked that the laboratory undertake an extensive program to improve the performance of the Allison V–1710 engine. The V–1710 was the only liquid-cooled engine used during World War II, and the military counted on it to power several types of fighter aircraft. The NACA instituted an Apprentice Program during the war to educate future mechanics, technicians, and electricians. The program was suspended for a number of years due to the increasing rates of military service by its participants. The laboratory continued its in-house education during the war, however, by offering a number of classes to its employees and lectures for the research staff. The classes and lectures were usually taught by fellow members of the staff, but occasionally external experts were brought in. The students in the Allison class in the Engine Research Building were taught how to completely disassemble and reassemble the engine components and systems. From left to right are Don Vining, Ed Cudlin, Gus DiNovo, George Larsen, Charles Diggs, Martin Lipes, Harley Roberts, Martin Berwaldt and John Dempsey. A.G. Covell is standing.

Steam Plant at the Aircraft Engine Research Laboratory

NASA Image and Video Library

1945-09-21

The Steam Plant at the National Advisory Committee for Aeronautics (NACA) Aircraft Engine Research Laboratory supplies steam to the major test facilities and office buildings. Steam is used for the Icing Research Tunnel's spray system and the Engine Research Building’s desiccant air dryers. In addition, its five boilers supply heat to various buildings and the cafeteria. Schirmer-Schneider Company built the $141,000 facility in the fall of 1942, and it has been in operation ever since.

Reducing the number of laboratory animals used in tissue engineering research by restricting the variety of animal models. Articular cartilage tissue engineering as a case study.

PubMed

de Vries, Rob B M; Buma, Pieter; Leenaars, Marlies; Ritskes-Hoitinga, Merel; Gordijn, Bert

2012-12-01

The use of laboratory animals in tissue engineering research is an important underexposed ethical issue. Several ethical questions may be raised about this use of animals. This article focuses on the possibilities of reducing the number of animals used. Given that there is considerable debate about the adequacy of the current animal models in tissue engineering research, we investigate whether it is possible to reduce the number of laboratory animals by selecting and using only those models that have greatest predictive value for future clinical application of the tissue engineered product. The field of articular cartilage tissue engineering is used as a case study. Based on a study of the scientific literature and interviews with leading experts in the field, an overview is provided of the animal models used and the advantages and disadvantages of each model, particularly in terms of extrapolation to the human situation. Starting from this overview, it is shown that, by skipping the small models and using only one large preclinical model, it is indeed possible to restrict the number of animal models, thereby reducing the number of laboratory animals used. Moreover, it is argued that the selection of animal models should become more evidence based and that researchers should seize more opportunities to choose or create characteristics in the animal models that increase their predictive value.

Adaptive laboratory evolution -- principles and applications for biotechnology.

PubMed

Dragosits, Martin; Mattanovich, Diethard

2013-07-01

Adaptive laboratory evolution is a frequent method in biological studies to gain insights into the basic mechanisms of molecular evolution and adaptive changes that accumulate in microbial populations during long term selection under specified growth conditions. Although regularly performed for more than 25 years, the advent of transcript and cheap next-generation sequencing technologies has resulted in many recent studies, which successfully applied this technique in order to engineer microbial cells for biotechnological applications. Adaptive laboratory evolution has some major benefits as compared with classical genetic engineering but also some inherent limitations. However, recent studies show how some of the limitations may be overcome in order to successfully incorporate adaptive laboratory evolution in microbial cell factory design. Over the last two decades important insights into nutrient and stress metabolism of relevant model species were acquired, whereas some other aspects such as niche-specific differences of non-conventional cell factories are not completely understood. Altogether the current status and its future perspectives highlight the importance and potential of adaptive laboratory evolution as approach in biotechnological engineering.

Proceedings of the 19th Annual Software Engineering Workshop

NASA Technical Reports Server (NTRS)

1994-01-01

The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of applications software. The goals of the SEL are: (1) to understand the software development process in the GSFC environment; (2) to measure the effects of various methodologies, tools, and models on this process; and (3) to identify and then to apply successful development practices. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that include this document.

Data collection procedures for the Software Engineering Laboratory (SEL) database

NASA Technical Reports Server (NTRS)

Heller, Gerard; Valett, Jon; Wild, Mary

1992-01-01

This document is a guidebook to collecting software engineering data on software development and maintenance efforts, as practiced in the Software Engineering Laboratory (SEL). It supersedes the document entitled Data Collection Procedures for the Rehosted SEL Database, number SEL-87-008 in the SEL series, which was published in October 1987. It presents procedures to be followed on software development and maintenance projects in the Flight Dynamics Division (FDD) of Goddard Space Flight Center (GSFC) for collecting data in support of SEL software engineering research activities. These procedures include detailed instructions for the completion and submission of SEL data collection forms.

Expedition 22 Change of Command in the U.S. Laboratory

NASA Image and Video Library

2010-03-17

ISS022-E-100383 (17 March 2010) --- Crew members aboard the International Space Station are pictured in the Destiny laboratory during the ceremony of Changing-of-Command from Expedition 22 to Expedition 23. Pictured are NASA astronauts Jeffrey Williams (right, holding microphone), Expedition 22 commander; and T.J. Creamer (second right), Expedition 22/23 flight engineer; Russian cosmonauts Oleg Kotov (left), Expedition 22 flight engineer and Expedition 23 commander; and Maxim Suraev (mostly obscured at left background), Expedition 22 flight engineer; along with Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi, Expedition 22/23 flight engineer.

Expedition 22 Change of Command in the U.S. Laboratory

NASA Image and Video Library

2010-03-17

ISS022-E-100363 (17 March 2010) --- Crew members aboard the International Space Station are pictured in the Destiny laboratory during the ceremony of Changing-of-Command from Expedition 22 to Expedition 23. Pictured are NASA astronauts Jeffrey Williams (right, holding microphone), Expedition 22 commander; and T.J. Creamer (center background), Expedition 22/23 flight engineer; Russian cosmonauts Oleg Kotov (left), Expedition 22 flight engineer and Expedition 23 commander; and Maxim Suraev (bottom), Expedition 22 flight engineer; along with Japan Aerospace Exploration Agency (JAXA) astronaut Soichi Noguchi (mostly out of frame at right), Expedition 22/23 flight engineer.

Energy and Water Conservation Assessment of the Radiochemical Processing Laboratory (RPL) at Pacific Northwest National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, Stephanie R.; Koehler, Theresa M.; Boyd, Brian K.

2014-05-31

This report summarizes the results of an energy and water conservation assessment of the Radiochemical Processing Laboratory (RPL) at Pacific Northwest National Laboratory (PNNL). The assessment was performed in October 2013 by engineers from the PNNL Building Performance Team with the support of the dedicated RPL staff and several Facilities and Operations (F&O) department engineers. The assessment was completed for the Facilities and Operations (F&O) department at PNNL in support of the requirements within Section 432 of the Energy Independence and Security Act (EISA) of 2007.

Development of natural gas rotary engines

NASA Astrophysics Data System (ADS)

Mack, J. R.

1991-08-01

Development of natural gas-fueled rotary engines was pursued on the parallel paths of converted Mazda automotive engines and of establishing technology and demonstration of a test model of a larger John Deer Technologies Incorporated (JDTI) rotary engine with power capability of 250 HP per power section for future production of multi-rotor engines with power ratings 250, 500, and 1000 HP and upward. Mazda engines were converted to natural gas and were characterized by a laboratory which was followed by nearly 12,000 hours of testing in three different field installations. To develop technology for the larger JDTI engine, laboratory and engine materials testing was accomplished. Extensive combustion analysis computer codes were modified, verified, and utilized to predict engine performance, to guide parameters for actual engine design, and to identify further improvements. A single rotor test engine of 5.8 liter displacement was designed for natural gas operation based on the JDTI 580 engine series. This engine was built and tested. It ran well and essentially achieved predicted performance. Lean combustion and low NOW emission were demonstrated.

Tracheal reaction to three different intraluminal stents in an animal model of tracheomalacia.

PubMed

Weinberg, Mark; Sandbank, Judith; Flumenblit, Yoseph; Klin, Baruch; Vinograd, Itzhak

2005-06-01

Three different internal airway stents were studied in an animal model of tracheomalacia: the Palmaz stent (Johnson & Johnson, Warren, New Jersey) and the NIR stent (Medinol Ltd., Tel Aviv, Israel)--both made of stainless steel in the form of tubular mesh--and the Nitinol stent, made of nickel-titanium formed into a spiral shape. All three stents could be adequately stabilized in the malacic tracheal segment. The Nitinol stent (Medinol Ltd., Tel Aviv, Israel) proved to be less reactive to the tracheal mucosa, demonstrated higher biocompatibility with significantly less granulation tissue formation, and showed superior radial resistance. Extraction of the Nitinol stent also proved to be much smoother. This stent may be the stent of choice in the treatment of tracheo- and bronchomalacia.

Mobile Text Messaging to Improve Medication Adherence and Viral Load in a Vulnerable Canadian Population Living With Human Immunodeficiency Virus: A Repeated Measures Study.

PubMed

King, Elizabeth; Kinvig, Karen; Steif, Jonathan; Qiu, Annie Q; Maan, Evelyn J; Albert, Arianne Yk; Pick, Neora; Alimenti, Ariane; Kestler, Mary H; Money, Deborah M; Lester, Richard T; Murray, Melanie Caroline Margaret

2017-06-01

Combination antiretroviral therapy (cART) as treatment for human immunodeficiency virus (HIV) infection is effective and available, but poor medication adherence limits benefits, particularly in vulnerable populations. In a Kenyan randomized controlled trial, a weekly text-messaging intervention (WelTel) improved cART adherence and HIV viral load (VL). Despite growing evidence for short message service (SMS) text-message interventions in HIV care, there is a paucity of data utilizing these interventions in marginalized or female cohorts. This study was undertaken to assess whether the standardized WelTel SMS text-message intervention applied to a vulnerable, predominantly female, population improved cART adherence and VL. We conducted a repeated measures study of the WelTel intervention in high-risk HIV-positive persons by measuring change in VL, CD4 count, and self-reported adherence 12 months before and 12 months after the WelTel intervention was introduced. Inclusion criteria included VL ≥200 copies/mL, indication for treatment, and meeting vulnerability criteria. Participants were given a mobile phone with unlimited texting (where required), and weekly check-in text messages were sent for one year from the WelTel computer platform. Clinical data were collected for control and intervention years. Participants were followed by a multidisciplinary team in a clinical setting. Outcomes were assessed using Wilcoxon signed ranks tests for change in CD4 and VL from control year to study end and mixed-effects logistic regressions for change in cART adherence and appointment attendance. A secondary analysis was conducted to assess the effect of response rate on the outcome by modeling final log 10 VL by number of responses while controlling for mean log 10 VL in the control year. Eighty-five participants enrolled in the study, but 5 withdrew (final N=80). Participants were predominantly female (90%, 72/80) with a variety of vulnerabilities. Mean VL decreased from 1098 copies/mL in the control year to 439 copies/mL at study end (P=.004). Adherence to cART significantly improved (OR 1.14, IQR 1.10-1.18; P<.001), whereas appointment attendance decreased slightly with the intervention (OR 0.81, IQR 0.67-0.99; P=.03). A response was received for 46.57% (1753/3764) of messages sent and 9.62% (362/3764) of text messages sent were replied to with a problem. An outcome analysis examining relationship between reply rate and VL did not meet statistical significance (P=.07), but may be worthy of investigating further in a larger study. WelTel may be an effective tool for improving cART adherence and reducing VLs among high-risk, vulnerable HIV-positive persons. Clinicaltrials.gov NCT02603536; https://clinicaltrials.gov/ct2/show/NCT02603536 (Archived by WebCite at http://www.webcitation.org/6qK57zCwv). ©Elizabeth King, Karen Kinvig, Jonathan Steif, Annie Q Qiu, Evelyn J Maan, Arianne YK Albert, Neora Pick, Ariane Alimenti, Mary H Kestler, Deborah M Money, Richard T Lester, Melanie Caroline Margaret Murray. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 01.06.2017.

ORFEUS spectroscopy of the O BT VI lines in symbiotic stars and the Raman scattering process

NASA Astrophysics Data System (ADS)

Schmid, H. M.; Krautter, J.; Appenzeller, I.; Barnstedt, J.; Dumm, T.; Fromm, A.; Gölz, M.; Grewing, M.; Gringel, W.; Haas, C.; Hopfensitz, W.; Kappelmann, N.; Krämer, G.; Lindenberger, A.; Mandel, H.; Mürset, U.; Schild, H.; Schmutz, W.; Widmann, H.

1999-08-01

We present orfeus spectra of the O vi lambda lambda 1032,1038 emission lines in the symbiotic stars AG Dra, V1016 Cyg, RR Tel, CD-43(deg) 14304, AG Peg and Z And. The O vi emission lines can convert into broad and highly polarized emission lines at lambda 6825 and lambda 7082 in a Raman scattering process by neutral hydrogen. From a comparison of direct and Raman scattered radiation we extract new information on the scattering geometry in symbiotic systems. The nebular O vi emission lines are in all objects redshifted by about +40 km s(-1) . This can be explained as a radiative line transfer effect in a slowly expanding emission region. A comparable redshift is measured in the Raman scattered O vi lines. In AG Peg the O vi emissions show beside a narrow nebular line a broad component from a fast stellar wind outflow. Many interstellar absorption lines of molecular hydrogen are detected, particularly near the O vi lambda 1038 component. With model calculations we investigate their impact on the O vi lines. From the dereddened line fluxes of the direct and Raman scattered O vi lines we derive the scattering efficiency, which is defined as photon flux ratio N_Raman/N_O VI. The efficiencies derived for RR Tel, V1016 Cyg and Z And indicate that about 30% of the released O vi lambda 1032 photons interact with the neutral scattering region. The efficiencies for AG Dra and CD-43(deg14304) are much higher, which may suggest that the O vi nebulosity is embedded in a H(0) -region. The D-type system RR Tel shows strong line profile differences between the direct O vi emission, which is single-peaked, and the Raman scattered emission, which is double-peaked. This indicates that the neutral scattering region in RR Tel ``sees'' different O vi line profiles, implying that the O vi nebulosity is far from spherically symmetric. In a tentative model we suggest for RR Tel an O vi flow pattern where material streams from the cool giant towards the hot component, which further accelerates the gas radially. For the S-type systems AG Dra, CD-43(deg14304) and Z And the line profile differences between the direct and the Raman scattered O vi emissions are less pronounced. This may suggest that the O vi profiles depend less on the emission direction than in the D-type system RR Tel. For AG Peg we detect for the first time the Raman scattered emission at lambda 6825. The Raman line shows a narrow, nebular component as the O vi line, but no equivalent emission to the broad O vi wind component. The higher conversion efficiency for the narrow component indicates that the nebular O vi emission is significantly closer to the cool giant than the hot, mass losing component, and strongly supports previous colliding wind models for this object. Based on observations taken during the orfeus-spas i and orfeus-spas ii space shuttle missions, and ground based data collected at the ESO 2.2m and 3.6m telescopes at La Silla, Chile, and the 4.2m William Herschel Telescope at La Palma, Canary Islands. ESO observations were granted for the programs 52.7-040 and 58.D-0866.

Building a Laboratory-Scale Biogas Plant and Verifying its Functionality

NASA Astrophysics Data System (ADS)

Boleman, Tomáš; Fiala, Jozef; Blinová, Lenka; Gerulová, Kristína

2011-01-01

The paper deals with the process of building a laboratory-scale biogas plant and verifying its functionality. The laboratory-scale prototype was constructed in the Department of Safety and Environmental Engineering at the Faculty of Materials Science and Technology in Trnava, of the Slovak University of Technology. The Department has already built a solar laboratory to promote and utilise solar energy, and designed SETUR hydro engine. The laboratory is the next step in the Department's activities in the field of renewable energy sources and biomass. The Department is also involved in the European Union project, where the goal is to upgrade all existed renewable energy sources used in the Department.

Synthesis of Hollow Gold-Silver Alloyed Nanoparticles: A "Galvanic Replacement" Experiment for Chemistry and Engineering Students

ERIC Educational Resources Information Center

Jenkins, Samir V.; Gohman, Taylor D.; Miller, Emily K.; Chen, Jingyi

2015-01-01

The rapid academic and industrial development of nanotechnology has led to its implementation in laboratory teaching for undergraduate-level chemistry and engineering students. This laboratory experiment introduces the galvanic replacement reaction for synthesis of hollow metal nanoparticles and investigates the optical properties of these…

Virtualisation of Engineering Discipline Experiments for an Internet-Based Remote Laboratory

ERIC Educational Resources Information Center

Tiwari, Rajiv; Singh, Khilawan

2011-01-01

A comprehensive survey on the Internet based virtualisation of experiments is presented, covering several individual as well as collaborative efforts in various engineering disciplines. From this survey it could be concluded that there is a pressing need to develop full-fledged remote laboratory experiments for integrated directly into engineering…

An industrial engineering approach to laboratory automation for high throughput screening

PubMed Central

Menke, Karl C.

2000-01-01

Across the pharmaceutical industry, there are a variety of approaches to laboratory automation for high throughput screening. At Sphinx Pharmaceuticals, the principles of industrial engineering have been applied to systematically identify and develop those automated solutions that provide the greatest value to the scientists engaged in lead generation. PMID:18924701

Improving the Laboratory Learning Experience: A Process to Train and Manage Teaching Assistants

ERIC Educational Resources Information Center

Nikolic, Sasha; Vial, Peter James; Ros, Montserrat; Stirling, David; Ritz, Christian

2015-01-01

This paper describes in detail a successful training program developed for sessional (part-time or nonpermanent) laboratory demonstrators employed in the Electrical Engineering Department of an Australian university. Such demonstrators play an important role in teaching practical concepts and skills in engineering. The success of the program…

Pre-Employment Laboratory Training. General Agricultural Mechanics Volume I. Instructional Materials.

ERIC Educational Resources Information Center

Texas A and M Univ., College Station. Vocational Instructional Services.

This course outline, the first volume of a two-volume set, consists of lesson plans for pre-employment laboratory training in general agricultural mechanics. Covered in the 12 lessons included in this volume are selecting tractors and engines, diagnosing engine conditions, servicing electrical systems, servicing cooling systems, servicing fuel and…

Anderson uses laptop computer in the U.S. Laboratory during Joint Operations

NASA Image and Video Library

2007-06-13

S117-E-07134 (12 June 2007) --- Astronaut Clayton Anderson, Expedition 15 flight engineer, uses a computer near the Microgravity Science Glovebox (MSG) in the Destiny laboratory of the International Space Station while Space Shuttle Atlantis (STS-117) was docked with the station. Astronaut Sunita Williams, flight engineer, is at right.

Fundamental Research in Engineering Education. Student Learning in Industrially Situated Virtual Laboratories

ERIC Educational Resources Information Center

Koretsky, Milo D.; Kelly, Christine; Gummer, Edith

2011-01-01

The instructional design and the corresponding research on student learning of two virtual laboratories that provide an engineering task situated in an industrial context are described. In this problem-based learning environment, data are generated dynamically based on each student team's distinct choices of reactor parameters and measurements.…

Development and Evaluation of a Mass Conservation Laboratory Module in a Microfluidics Environment

ERIC Educational Resources Information Center

King, Andrew C.; Hidrovo, Carlos H.

2015-01-01

Laboratory-based instruction is a powerful educational tool that engages students in Science, Technology, Engineering and Mathematics (STEM) disciplines beyond textbook theory. This is true in mechanical engineering education and is often used to provide collegiate-level students a hands-on alternative to course theory. Module-based laboratory…

MTR WING A, TRA604, INTERIOR. MAIN FLOOR. DETAIL VIEW INSIDE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

MTR WING A, TRA-604, INTERIOR. MAIN FLOOR. DETAIL VIEW INSIDE LABORATORY 114. CAMERA FACING NORTH. DISPOSAL OF RADIOACTIVE MATERIALS IS UNDERWAY. INL NEGATIVE NO. HD46-12-4. Mike Crane, Photographer, 2/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

E-Learning in Engineering Education: Design of a Collaborative Advanced Remote Access Laboratory

ERIC Educational Resources Information Center

Chandra A. P., Jagadeesh; Samuel, R. D. Sudhaker

2010-01-01

Attaining excellence in technical education is a worthy challenge to any life goal. Distance learning opportunities make these goals easier to reach with added quality. Distance learning in engineering education is possible only through successful implementations of remote laboratories in a learning-by-doing environment. This paper presents one…

Development and Testing of an Experimental Mobile Instructional Facility for Applied Courses in Engineering Technology.

ERIC Educational Resources Information Center

Kleine, Louis W.

The experimental pilot project was conducted to determine whether students who take the laboratory phase of an engineering technology applied electricity course in a mobile laboratory at branch schools demonstrate proficiency comparable to students who take the applied electricity course in permanent facilities at the parent institution. The…

Engineering study for closure of 209E facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brevick, C.H.; Heys, W.H.; Johnson, E.D.

1997-07-07

This document is an engineering study for evaluating alternatives to determine the most cost effective closure plan for the 209E Facility, Critical Mass Laboratory. This laboratory is located in the 200 East Area of the Hanford Site and contains a Critical Assembly Room and a Mix room were criticality experiments were once performed.

Entrance to the NACA's Flight Propulsion Research Laboratory

NASA Image and Video Library

1948-08-21

The sign near the entrance of the National Advisory Committee for Aeronautics (NACA) Flight Propulsion Research Laboratory. The name was changed several weeks later to the Lewis Flight Propulsion Laboratory in honor of the NACA’s former Director of Aeronautical Research, George W. Lewis. The research laboratory has had five different names since its inception in 1941. The Cleveland laboratory was originally known as the NACA Aircraft Engine Research Laboratory. In 1947 it was renamed the NACA Flight Propulsion Research Laboratory to reflect the expansion of the research activities beyond just engines. Following the death of George Lewis, the name was changed to the NACA Lewis Flight Propulsion Laboratory in September 1948. On October 1, 1958, the lab was incorporated into the new NASA space agency, and it was renamed the NASA Lewis Research Center. Following John Glenn’s flight on the space shuttle, the name was changed again to the NASA Glenn Research Center on March 1, 1999. From his office in Washington DC, George Lewis managed the aeronautical research conducted at the NACA for over 20 years. His most important accomplishment, however, may have been an investigative tour of German research facilities in the fall of 1936. The visit resulted in the broadening of the scope of the NACA’s research and the physical expansion that included the new engine laboratory in Cleveland.

Evaluation TRMM Rainfall Data In Hydrological Modeling For An Ungaged In Lhasa River Basin

NASA Astrophysics Data System (ADS)

Ji, H. J.; Liu, J.

2017-12-01

Evaluation TRMM Rainfall Data In Hydrological Modeling For An Ungaged In Lhasa River BasinHaijuan Ji1* Jintao Liu1,2 Shanshan Xu1___________________ 1College of Hydrology and Water Resources, Hohai University, Nanjing 210098, People's Republic of China 2State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Hohai University, Nanjing 210098, People's Republic of China ___________________ * Corresponding author. Tel.: +86-025-83786973; Fax: +86-025-83786606. E-mail address: Hhu201510@163.com (H.J. Ji). Abstract: The Tibetan Plateau plays an important role in regulating the regional hydrological processes due to its high elevations and being the headwaters of many major Asian river basins. If familiar with the distribution of hydrological characteristics, will help us improve the level of development and utilization the water resources. However, there exist glaciers and snow with few sites. It is significance for us to understand the glacier and snow hydrological process in order to recognize the evolution of water resources in the Tibetan. This manuscript takes Lhasa River as the study area, taking use of ground, remote sensing and assimilation data, taking advantage of high precision TRMM precipitation data and MODIS snow cover data, first, according to the data from ground station evaluation of TRMM data in the application of the accuracy of the Lhasa River, and based on MODIS data fusion of multi source microwave snow making cloudless snow products, which are used for discriminant and analysis glacier and snow regulation mechanism on day scale, add snow and glacier unit into xinanjing model, this model can simulate the study region's runoff evolution, parameter sensitivity even spatial variation of hydrological characteristics the next ten years on region grid scale. The results of hydrological model in Lhasa River can simulate the glacier and snow runoff variation in high cold region better, to enhance the predictive ability of the spring snow disaster.

Primary Exhaust Cooler at the Propulsion Systems Laboratory

NASA Image and Video Library

1952-09-21

One of the two primary coolers at the Propulsion Systems Laboratory at the National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory. Engines could be run in simulated altitude conditions inside the facility’s two 14-foot-diameter and 24-foot-long test chambers. The Propulsion Systems Laboratory was the nation’s only facility that could run large full-size engine systems in controlled altitude conditions. At the time of this photograph, construction of the facility had recently been completed. Although not a wind tunnel, the Propulsion Systems Laboratory generated high-speed airflow through the interior of the engine. The air flow was pushed through the system by large compressors, adjusted by heating or refrigerating equipment, and de-moisturized by air dryers. The exhaust system served two roles: reducing the density of the air in the test chambers to simulate high altitudes and removing hot gases exhausted by the engines being tested. It was necessary to reduce the temperature of the extremely hot engine exhaust before the air reached the exhauster equipment. As the air flow exited through exhaust section of the test chamber, it entered into the giant primary cooler seen in this photograph. Narrow fins or vanes inside the cooler were filled with water. As the air flow passed between the vanes, its heat was transferred to the cooling water. The cooling water was cycled out of the system, carrying with it much of the exhaust heat.

Spinal Muscular Atrophy

MedlinePlus

... length SMN protein, which is critical for the maintenance of motor neurons. Muscle relaxants such as baclofen, ... Tel: 703-299-1144 Cure SMA 925 Busse Road Elk Grove Village, IL 60007 info@fsma.org ...

NASA Center for Intelligent Robotic Systems for Space Exploration

NASA Technical Reports Server (NTRS)

1990-01-01

NASA's program for the civilian exploration of space is a challenge to scientists and engineers to help maintain and further develop the United States' position of leadership in a focused sphere of space activity. Such an ambitious plan requires the contribution and further development of many scientific and technological fields. One research area essential for the success of these space exploration programs is Intelligent Robotic Systems. These systems represent a class of autonomous and semi-autonomous machines that can perform human-like functions with or without human interaction. They are fundamental for activities too hazardous for humans or too distant or complex for remote telemanipulation. To meet this challenge, Rensselaer Polytechnic Institute (RPI) has established an Engineering Research Center for Intelligent Robotic Systems for Space Exploration (CIRSSE). The Center was created with a five year $5.5 million grant from NASA submitted by a team of the Robotics and Automation Laboratories. The Robotics and Automation Laboratories of RPI are the result of the merger of the Robotics and Automation Laboratory of the Department of Electrical, Computer, and Systems Engineering (ECSE) and the Research Laboratory for Kinematics and Robotic Mechanisms of the Department of Mechanical Engineering, Aeronautical Engineering, and Mechanics (ME,AE,&M), in 1987. This report is an examination of the activities that are centered at CIRSSE.

Crack-Detection Experiments on Simulated Turbine Engine Disks in NASA Glenn Research Center's Rotordynamics Laboratory

NASA Technical Reports Server (NTRS)

Woike, Mark R.; Abdul-Aziz, Ali

2010-01-01

The development of new health-monitoring techniques requires the use of theoretical and experimental tools to allow new concepts to be demonstrated and validated prior to use on more complicated and expensive engine hardware. In order to meet this need, significant upgrades were made to NASA Glenn Research Center s Rotordynamics Laboratory and a series of tests were conducted on simulated turbine engine disks as a means of demonstrating potential crack-detection techniques. The Rotordynamics Laboratory consists of a high-precision spin rig that can rotate subscale engine disks at speeds up to 12,000 rpm. The crack-detection experiment involved introducing a notch on a subscale engine disk and measuring its vibration response using externally mounted blade-tip-clearance sensors as the disk was operated at speeds up to 12 000 rpm. Testing was accomplished on both a clean baseline disk and a disk with an artificial crack: a 50.8-mm- (2-in.-) long introduced notch. The disk s vibration responses were compared and evaluated against theoretical models to investigate how successful the technique was in detecting cracks. This paper presents the capabilities of the Rotordynamics Laboratory, the baseline theory and experimental setup for the crack-detection experiments, and the associated results from the latest test campaign.

FY 2014 LDRD Annual Report Project Summaries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tomchak, Dena

The FY 2014 Laboratory Directed Research and Development (LDRD) Annual Report is a compendium of the diverse research performed to develop and ensure the INL's technical capabilities can support future DOE missions and national research priorities. LDRD is essential to INL - it provides a means for the laboratory to pursue novel scientific and engineering research in areas that are deemed too basic or risky for programmatic investments. This research enahnces technical capabilities at the laboratory, providing scientific and engineering staff with opportunities for skill building and partnership development.

NLS Flight Simulation Laboratory (FSL) documentation

NASA Technical Reports Server (NTRS)

1995-01-01

The Flight Simulation Laboratory (FSL) Electronic Documentation System design consists of modification and utilization of the MSFC Integrated Engineering System (IES), translation of the existing FSL documentation to an electronic format, and generation of new drawings to represent the Engine Flight Simulation Laboratory design and implementation. The intent of the electronic documentation is to provide ease of access, local print/plot capabilities, as well as the ability to correct and/or modify the stored data by network users who are authorized to access this information.

List of DOE radioisotope customers with summary of radioisotope shipments FY 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burlison, J.S.; Laidler, R.I.

1979-05-01

The purpose of the document is to list DOE's radioisotopes production and distribution activities by its facilities at Argonne National Laboratory; Pacific Northwest Laboratory; Brookhaven National Laboratory; Hanford Engineering Development Laboratory; Idaho Operations Office; Los Alamos Scientific Laboratory; Mound Facility; Oak Ridge National Laboratory; Savannah River Laboratory; and UNC Nuclear Industries, Inc.

A Virtual Embedded Microcontroller Laboratory for Undergraduate Education: Development and Evaluation

ERIC Educational Resources Information Center

Richardson, Jeffrey J.; Adamo-Villani, Nicoletta

2010-01-01

Laboratory instruction is a major component of the engineering and technology undergraduate curricula. Traditional laboratory instruction is hampered by several factors including limited access to resources by students and high laboratory maintenance cost. A photorealistic 3D computer-simulated laboratory for undergraduate instruction in…

Cushing's Syndrome

MedlinePlus

... Support and Research Foundation 60 Robbins, #12 Plymouth MA Plymouth, MA 02360 cushinfo@csrf.net http://csrf.net Tel: ... Support and Research Foundation 60 Robbins, #12 Plymouth MA Plymouth, MA 02360 cushinfo@csrf.net http://csrf. ...

Apparatus Notes.

ERIC Educational Resources Information Center

Eaton, Bruce G., Ed.

1982-01-01

Presents a technique to produce samples for x-ray diffraction studies on the Tel-X-Ometer 80 x-ray apparatus from readily available crystalline powders and discusses observations of transverse modes of an optical resonator. (SK)

Hypersomnia

MedlinePlus

... 5885 Cumming Highway Suite 108-255 Sugar Hill GA Sugar Hill, GA 30518 http://www.hypersomniafoundation.org Tel: 844-342- ... 5885 Cumming Highway Suite 108-255 Sugar Hill GA Sugar Hill, GA 30518 http://www.hypersomniafoundation.org ...

Effect of Urea on G-Quadruplex Stability.

PubMed

Aslanyan, Lusine; Ko, Jordan; Kim, Byul G; Vardanyan, Ishkhan; Dalyan, Yeva B; Chalikian, Tigran V

2017-07-13

G-quadruplexes represent a class of noncanonical nucleic acid structures implicated in transcriptional regulation, cellular function, and disease. An understanding of the forces involved in stabilization and destabilization of the G-quadruplex conformation relative to the duplex or single-stranded conformation is a key to elucidating the biological role of G-quadruplex-based genomic switches and the quest for therapeutic means for controlled induction or suppression of a G-quadruplex at selected genomic loci. Solute-solvent interactions provide a ubiquitous and, in many cases, the determining thermodynamic force in maintaining and modulating the stability of nucleic acids. These interactions involve water as well as water-soluble cosolvents that may be present in the solution or in the crowded environment in the cell. We present here the first quantitative investigation of the effect of urea, a destabilizing cosolvent, on the conformational preferences of a G-quadruplex formed by the telomeric d[A(G 3 T 2 A) 3 G 3 ] sequence (Tel22). At 20 mM NaCl and room temperature, Tel22 undergoes a two-state urea-induced unfolding transition. An increase in salt mitigates the deleterious effect of urea on Tel22. The urea m-value of Tel22 normalized per change in solvent-accessible surface area, ΔS A , is similar to those for other DNA and RNA structures while being several-fold larger than that of proteins. Our results suggest that urea can be employed as an analytical tool in thermodynamic characterizations of G-quadruplexes in a manner similar to the use of urea in protein studies. We emphasize the need for further studies involving a larger selection of G-quadruplexes varying in sequence, topology (parallel, antiparallel, hybrid), and molecularity (monomolecular, bimolecular, tetramolecular) to outline the advantages and the limits of the use of urea in G-quadruplex studies. A deeper understanding of the effect of solvent and cosolvents on the differential stability of the G-quadruplex and duplex conformations is a step toward elucidation of the modulating influence of different types of cosolvents on duplex-G-quadruplex molecular switches triggering genomic events.

NASA Glenn's Engine Components Research Lab, Cell 2B, Reactivated to Support the U.S. Army Research Laboratory T700 Engine Test

NASA Technical Reports Server (NTRS)

Beltran, Luis R.; Griffin, Thomas A.

2004-01-01

The U.S. Army Vehicle Technology Directorate at the NASA Glenn Research Center has been directed by their parent command, the U.S. Army Research Laboratory (ARL), to demonstrate active stall technology in a turboshaft engine as the next step in transitioning this technology to the Army and aerospace industry. Therefore, the Vehicle Technology Directorate requested the reactivation of Glenn's Engine Components Research Lab, Cell 2B, (ECRL 2B). They wanted to test a T700 engine that had been used previously for turboshaft engine research as a partnership between the Army and NASA on small turbine engine research. ECRL 2B had been placed in standby mode in 1997. Glenn's Testing Division initiated reactivation in May 2002 to support the new research effort, and they completed reactivation and improvements in September 2003.

Software Engineering Laboratory (SEL) Data Base Maintenance System (DBAM) user's guide and system description

NASA Technical Reports Server (NTRS)

Lo, P. S.; Card, D.

1983-01-01

The Software Engineering Laboratory (SEL) Data Base Maintenance System (DBAM) is explained. The various software facilities of the SEL, DBAM operating procedures, and DBAM system information are described. The relationships among DBAM components (baseline diagrams), component descriptions, overlay descriptions, indirect command file listings, file definitions, and sample data collection forms are provided.

Emulation-Based Virtual Laboratories: A Low-Cost Alternative to Physical Experiments in Control Engineering Education

ERIC Educational Resources Information Center

Goodwin, G. C.; Medioli, A. M.; Sher, W.; Vlacic, L. B.; Welsh, J. S.

2011-01-01

This paper argues the case for emulation-based virtual laboratories in control engineering education. It demonstrates that such emulation experiments can give students an industrially relevant educational experience at relatively low cost. The paper also describes a particular emulation-based system that has been developed with the aim of giving…

View of an Expedition 21 Crew Member trimming his hair in the Destiny Laboratory

NASA Image and Video Library

2009-10-11

ISS021-E-005067 (11 Oct. 2009) --- Russian cosmonaut Maxim Suraev, Expedition 21 flight engineer, trims his hair in the Destiny laboratory of the International Space Station, using hair clippers fashioned with a vacuum device to garner freshly cut hair. Canadian Space Agency astronaut Robert Thirsk, flight engineer, is at right.

Investigation of specification measures for the Software Engineering Laboratory (SEL)

NASA Technical Reports Server (NTRS)

1984-01-01

Requirements specification measures are investigated for potential application in the Software Engineering Laboratory. Eighty-seven candidate measures are defined; sixteen are recommended for use. Most measures are derived from a new representation, the Composite Specification Model, which is introduced. The results of extracting the specification measures from the requirements of a real system are described.

Renewable Fuels and Lubricants Laboratory | Transportation Research | NREL

Science.gov Websites

delivery vans to full-size buses and Class 8 tractors. Heavy-Duty and Light-Duty Engine Dynamometer Test Cells The ReFUEL Laboratory features two engine dynamometer test cells-one for heavy-duty (up to 600 hp the Heavy-Duty Federal Test Procedures (HD-FTP), are highly standardized, and results can be readily

Classroom Experiences in an Engineering Design Graphics Course with a CAD/CAM Extension.

ERIC Educational Resources Information Center

Barr, Ronald E.; Juricic, Davor

1997-01-01

Reports on the development of a new CAD/CAM laboratory experience for an Engineering Design Graphics (EDG) course. The EDG curriculum included freehand sketching, introduction to Computer-Aided Design and Drafting (CADD), and emphasized 3-D solid modeling. Reviews the project and reports on the testing of the new laboratory components which were…

Adsorption of Oxy-Anions in the Teaching Laboratory: An Experiment to Study a Fundamental Environmental Engineering Problem

ERIC Educational Resources Information Center

D'Arcy, Mitch; Bullough, Florence; Moffat, Chris; Borgomeo, Edoardo; Teh, Micheal; Vilar, Ramon; Weiss, Dominik J.

2014-01-01

Synthesizing and testing bicomposite adsorbents for the removal of environmentally problematic oxy-anions is high on the agenda of research-led universities. Here we present a laboratory module successfully developed at Imperial College London that introduces the advanced undergraduate student in engineering (chemical, civil, earth) and science…

Vertical and Horizontal Integration of Laboratory Curricula and Course Projects across the Electronic Engineering Technology Program

ERIC Educational Resources Information Center

Zhan, Wei; Goulart, Ana; Morgan, Joseph A.; Porter, Jay R.

2011-01-01

This paper discusses the details of the curricular development effort with a focus on the vertical and horizontal integration of laboratory curricula and course projects within the Electronic Engineering Technology (EET) program at Texas A&M University. Both software and hardware aspects are addressed. A common set of software tools are…

Comparison of High-Speed Operating Characteristics of Size 215 Cylindrical-Roller Bearings as Determined in Turbojet Engine and in Laboratory Test Rig

NASA Technical Reports Server (NTRS)

Macks, E Fred; Nemeth, Zolton N

1951-01-01

A comparison of the operating characteristics of 75-millimeter-bore (size 215) cylindrical-roller one-piece inner-race-riding cage-type bearings was made using a laboratory test rig and a turbojet engine. Cooling correlation parameters were determined by means of dimensional analysis, and the generalized results for both the inner- and outer-race bearing operating temperatures are compared for the laboratory test rig and the turbojet engine. Inner- and outer-race cooling-correlation curves were obtained for the turbojet-engine turbine-roller bearing with the same inner- and outer-race correlation parameters and exponents as those determined for the laboratory test-rig bearing. The inner- and outer-race turbine roller-bearing temperatures may be predicted from a single curve, regardless of variations in speed, load, oil flow, oil inlet temperature, oil inlet viscosity, oil-jet diameter or any combination of these parameters. The turbojet-engine turbine-roller-bearing inner-race temperatures were 30 to 60 F greater than the outer-race-maximum temperatures, the exact values depending on the operating condition and oil viscosity; these results are in contrast to the laboratory test-rig results where the inner-race temperatures were less than the outer-race-maximum temperatures. The turbojet-engine turbine-roller bearing, maximum outer-race circumferential temperature variation was approximately 30 F for each of the oils used. The effect of oil viscosity on inner- and outer-race turbojet-engine turbine-roller-bearing temperatures was found to be significant. With the lower viscosity oil (6x10(exp -7) reyns (4.9 centistokes) at 100 F; viscosity index, 83), the inner-race temperature was approximately 30 to 35 F less than with the higher viscosity oil (53x10(exp -7) reyns (42.8 centistokes) at 100 F; viscosity index, 150); whereas the outer-race-maximum temperatures were 12 to 28 F lower with the lower viscosity oil over the DN range investigated.

Progress and opportunities for tissue-engineered skin

NASA Astrophysics Data System (ADS)

MacNeil, Sheila

2007-02-01

Tissue-engineered skin is now a reality. For patients with extensive full-thickness burns, laboratory expansion of skin cells to achieve barrier function can make the difference between life and death, and it was this acute need that drove the initiation of tissue engineering in the 1980s. A much larger group of patients have ulcers resistant to conventional healing, and treatments using cultured skin cells have been devised to restart the wound-healing process. In the laboratory, the use of tissue-engineered skin provides insight into the behaviour of skin cells in healthy skin and in diseases such as vitiligo, melanoma, psoriasis and blistering disorders.

Improving Consistency in Large Laboratory Courses: A Design for a Standardized Practical Exam

ERIC Educational Resources Information Center

Chen, Xinnian; Graesser, Donnasue; Sah, Megha

2015-01-01

Laboratory courses serve as important gateways to science, technology, engineering, and mathematics education. One of the challenges in assessing laboratory learning is to conduct meaningful and standardized practical exams, especially for large multisection laboratory courses. Laboratory practical exams in life sciences courses are frequently…

Remote Access to Wireless Communications Systems Laboratory--New Technology Approach

ERIC Educational Resources Information Center

Kafadarova, Nadezhda; Sotirov, Sotir; Milev, Mihail

2012-01-01

Technology nowadays enables the remote access to laboratory equipment and instruments via Internet. This is especially useful in engineering education, where students can conduct laboratory experiment remotely. Such remote laboratory access can enable students to use expensive laboratory equipment, which is not usually available to students. In…

The potential of tissue engineering for developing alternatives to animal experiments: a systematic review.

PubMed

de Vries, Rob B M; Leenaars, Marlies; Tra, Joppe; Huijbregtse, Robbertjan; Bongers, Erik; Jansen, John A; Gordijn, Bert; Ritskes-Hoitinga, Merel

2015-07-01

An underexposed ethical issue raised by tissue engineering is the use of laboratory animals in tissue engineering research. Even though this research results in suffering and loss of life in animals, tissue engineering also has great potential for the development of alternatives to animal experiments. With the objective of promoting a joint effort of tissue engineers and alternative experts to fully realise this potential, this study provides the first comprehensive overview of the possibilities of using tissue-engineered constructs as a replacement of laboratory animals. Through searches in two large biomedical databases (PubMed, Embase) and several specialised 3R databases, 244 relevant primary scientific articles, published between 1991 and 2011, were identified. By far most articles reviewed related to the use of tissue-engineered skin/epidermis for toxicological applications such as testing for skin irritation. This review article demonstrates, however, that the potential for the development of alternatives also extends to other tissues such as other epithelia and the liver, as well as to other fields of application such as drug screening and basic physiology. This review discusses which impediments need to be overcome to maximise the contributions that the field of tissue engineering can make, through the development of alternative methods, to the reduction of the use and suffering of laboratory animals. Copyright © 2013 John Wiley & Sons, Ltd.

Multi-Organization Multi-Discipline Effort Developing a Mitigation Concept for Planetary Defense

NASA Technical Reports Server (NTRS)

Leung, Ronald Y.; Barbee, Brent W.; Seery, Bernard D.; Bambacus, Myra; Finewood, Lee; Greenaugh, Kevin C.; Lewis, Anthony; Dearborn, David; Miller, Paul L.; Weaver, Robert P.;

A senior manufacturing laboratory for determining injection molding process capability

NASA Technical Reports Server (NTRS)

Wickman, Jerry L.; Plocinski, David

1992-01-01

The following is a laboratory experiment designed to further understanding of materials science. This subject material is directed at an upper level undergraduate/graduate student in an Engineering or Engineering Technology program. It is assumed that the student has a thorough understanding of the process and quality control. The format of this laboratory does not follow that which is normally recommended because of the nature of process capability and that of the injection molding equipment and tooling. This laboratory is instead developed to be used as a point of departure for determining process capability for any process in either a quality control laboratory or a manufacturing environment where control charts, process capability, and experimental or product design are considered important topics.

2000-hour cyclic endurance test of a laboratory model multipropellant resistojet

NASA Technical Reports Server (NTRS)

Morren, W. Earl; Sovey, James S.

1987-01-01

The technological readiness of a long-life multipropellant resistojet for space station auxiliary propulsion is demonstrated. A laboratory model resistojet made from grain-stabilized platinum served as a test bed to evaluate the design characteristics, fabrication methods, and operating strategies for an engineering model multipropellant resistojet developed under contract by the Rocketdyne Division of Rockwell International and Technion Incorporated. The laboratory model thruster was subjected to a 2000-hr, 2400-thermal-cycle endurance test using carbon dioxide propellant. Maximum thruster temperatures were approximately 1400 C. The post-test analyses of the laboratory model thruster included an investigation of component microstructures. Significant observations from the laboratory model thruster are discussed as they relate to the design of the engineering model thruster.

A 2000-hour cyclic endurance test of a laboratory model multipropellant resistojet

NASA Technical Reports Server (NTRS)

Morren, W. Earl; Sovey, James S.

1987-01-01

The technological readiness of a long-life multipropellant resistojet for space station auxiliary propulsion is demonstrated. A laboratory model resistojet made from grain-stabilized platinum served as a test bed to evaluate the design characteristics, fabrication methods, and operating strategies for an engineering model multipropellant resistojet developed under contract by the Rocketdyne Division of Rockwell International and Technion Incorporated. The laboratory model thruster was subjected to a 2000-hr, 2400-thermal-cycle endurance test using carbon dioxide propellant. Maximum thruster temperatures were approximately 1400 C. The post-test analyses of the laboratory model thruster included an investigation of component microstructures. Significant observations from the laboratory model thruster are discussed as they relate to the design of the engineering model thruster.

Model of the NACA's Aircraft Engine Research Laboratory during its Construction

NASA Image and Video Library

1942-08-21

Zella Morewitz poses with a model of the National Advisory Committee for Aeronautics (NACA) Aircraft Engine Research Laboratory, currently the NASA Glenn Research Center. The model was displayed in the Administration Building during the construction of the laboratory in the early 1940s. Detailed models of the individual test facilities were also fabricated and displayed in the facilities. The laboratory was built on a wedge of land between the Cleveland Municipal Airport on the far side and the deep curving valley etched by the Rocky River on the near end. Roughly only a third of the laboratory's semicircle footprint was initially utilized. Additional facilities were added to the remaining areas in the years after World War II. In the late 1950s the site was supplemented by the acquisition of additional adjacent land. Morewitz joined the NACA in 1935 as a secretary in the main office at the Langley Memorial Aeronautical Laboratory. In September 1940 she took on the task of setting up and guiding an office dedicated to the design of the NACA’s new engine research laboratory. Morewitz and the others in the design office transferred to Cleveland in December 1941 to expedite the construction. Morewitz served as Manager Ray Sharp’s secretary for six years and was a popular figure at the new laboratory. In December 1947 Morewitz announced her engagement to Langley researcher Sidney Batterson and moved back to Virginia.

National Vehicle and Fuel Emissions Laboratory (NVFEL)

EPA Pesticide Factsheets

NVFEL is the primary EPA research laboratory used for fuel and emissions testing. The laboratory supports emission standards for motor vehicles, engines, and fuels, as well as the development of automotive technology.

Interior of Vacuum Tank at the Electric Propulsion Laboratory

NASA Image and Video Library

1961-08-21

Interior of the 20-foot diameter vacuum tank at the NASA Lewis Research Center’s Electric Propulsion Laboratory. Lewis researchers had been studying different electric rocket propulsion methods since the mid-1950s. Harold Kaufman created the first successful ion engine, the electron bombardment ion engine, in the early 1960s. These engines used electric power to create and accelerate small particles of propellant material to high exhaust velocities. Electric engines have a very small thrust, but can operate for long periods of time. The ion engines are often clustered together to provide higher levels of thrust. The Electric Propulsion Laboratory, which began operation in 1961, contained two large vacuum tanks capable of simulating a space environment. The tanks were designed especially for testing ion and plasma thrusters and spacecraft. The larger 25-foot diameter tank included a 10-foot diameter test compartment to test electric thrusters with condensable propellants. The portals along the chamber floor lead to the massive exhauster equipment that pumped out the air to simulate the low pressures found in space.

Brain and Spinal Tumors

MedlinePlus

... National Home Office 250 Williams Street, NW Atlanta GA Atlanta, GA 30303-1002 http://www.cancer.org Tel: 800- ... National Home Office 250 Williams Street, NW Atlanta GA Atlanta, GA 30303-1002 http://www.cancer.org ...

YSAR: a compact low-cost synthetic aperture radar

NASA Astrophysics Data System (ADS)

Thompson, Douglas G.; Arnold, David V.; Long, David G.; Miner, Gayle F.; Karlinsey, Thomas W.; Robertson, Adam E.

1997-09-01

The Brigham Young University Synthetic Aperture Radar (YSAR) is a compact, inexpensive SAR system which can be flown on a small aircraft. The system has exhibited a resolution of approximately 0.8 m by 0.8 m in test flights in calm conditions. YSAR has been used to collect data over archeological sites in Israel. Using a relatively low frequency (2.1 GHz), we hope to be able to identify walls or other archeological features to assist in excavation. A large data set of radar and photographic data have been collected over sites at Tel Safi, Qumran, Tel Micnah, and the Zippori National Forest in Israel. We show sample images from the archeological data. We are currently working on improved autofocus algorithms for this data and are developing a small, low-cost interferometric SAR system (YINSAR) for operation from a small aircraft.

Differences in methylphenidate abuse rates among methadone maintenance treatment patients in two clinics.

PubMed

Peles, Einat; Schreiber, Shaul; Linzy, Shirley; Domani, Yoav; Adelson, Miriam

2015-07-01

Methylphenidate, an amphetamine-like prescription medication for attention deficit hyperactivity disorder (ADHD) was suspected as being abused among methadone maintenance treatment (MMT) patients. We tested its presence in the routine urine monitoring of all patients in both Tel Aviv and Las Vegas MMT clinics. Data on demographic and addiction history, ADHD (Wender Utah Rating Scale), cognitive impairment (Mini Mental State Exam), and lifetime DSM-IV-TR psychiatric diagnosis from admission were retrieved, and retention following 6 months. None of the 190 patients in Las Vegas tested positive for methylphenidate, while 14.7% (45/306) did in Tel Aviv. Abusers were less educated (p = 0.01), had higher ADHD scores (p = 0.02), lower cognitive scores (p = 0.05), and a higher benzodiazepine (BDZ) abuse rate (p < 0.0005), with no difference in age, gender, duration in MMT, cannabis, opiates, and cocaine abuse and infectious disease. Of the methylphenidate abuse 42.2% have take-home methadone dose privileges. Not like opiate use, being methylphenidate positive did not relate to 6-months retention. Compared to Tel Aviv, Las Vegas patients were more educated, with lower BDZ, and cocaine abuse. The greater abuse of methylphenidate among ADHD subjects might indicate their using it as self-medication, raising a possible indication for its prescription for that subgroup of MMT patients. The high rate of methylphenidate abuse in Israel needs future study. Copyright © 2015 Elsevier Inc. All rights reserved.

Biomedical engineering at Sandia National Laboratories

NASA Astrophysics Data System (ADS)

Zanner, Mary Ann

1994-12-01

The potential exists to reduce or control some aspects of the U.S. health care expenditure without compromising health care delivery by developing carefully selected technologies which impact favorably on the health care system. A focused effort to develop such technologies is underway at Sandia National Laboratories. As a DOE National Laboratory, Sandia possesses a wealth of engineering and scientific expertise that can be readily applied to this critical national need. Appropriate mechanisms currently exist to allow transfer of technology from the laboratory to the private sector. Sandia's Biomedical Engineering Initiative addresses the development of properly evaluated, cost-effective medical technologies through team collaborations with the medical community. Technology development is subjected to certain criteria including wide applicability, earlier diagnoses, increased efficiency, cost-effectiveness and dual-use. Examples of Sandia's medical technologies include a noninvasive blood glucose sensor, computer aided mammographic screening, noninvasive fetal oximetry and blood gas measurement, burn diagnostics and laser debridement, telerobotics and ultrasonic scanning for prosthetic devices. Sandia National Laboratories has the potential to aid in directing medical technology development efforts which emphasize health care needs, earlier diagnosis, cost containment and improvement of the quality of life.

Adaptive laboratory evolution – principles and applications for biotechnology

PubMed Central

2013-01-01

Adaptive laboratory evolution is a frequent method in biological studies to gain insights into the basic mechanisms of molecular evolution and adaptive changes that accumulate in microbial populations during long term selection under specified growth conditions. Although regularly performed for more than 25 years, the advent of transcript and cheap next-generation sequencing technologies has resulted in many recent studies, which successfully applied this technique in order to engineer microbial cells for biotechnological applications. Adaptive laboratory evolution has some major benefits as compared with classical genetic engineering but also some inherent limitations. However, recent studies show how some of the limitations may be overcome in order to successfully incorporate adaptive laboratory evolution in microbial cell factory design. Over the last two decades important insights into nutrient and stress metabolism of relevant model species were acquired, whereas some other aspects such as niche-specific differences of non-conventional cell factories are not completely understood. Altogether the current status and its future perspectives highlight the importance and potential of adaptive laboratory evolution as approach in biotechnological engineering. PMID:23815749

Cleaner, More Efficient Diesel Engines

ScienceCinema

Musculus, Mark

2018-01-16

Mark Musculus, an engine combustion scientist at Sandia National Laboratories, led a study that outlines the science base for auto and engine manufacturers to build the next generation of cleaner, more efficient engines using low-temperature combustion. Here, Musculus discusses the work at Sandia's Combustion Research Facility.

Ice Crystal Icing Engine Testing in the NASA Glenn Research Center's Propulsion Systems Laboratory: Altitude Investigation

NASA Technical Reports Server (NTRS)

Oliver, Michael J.

2014-01-01

The National Aeronautics and Space Administration (NASA) conducted a full scale ice crystal icing turbofan engine test using an obsolete Allied Signal ALF502-R5 engine in the Propulsion Systems Laboratory (PSL) at NASA Glenn Research Center. The test article used was the exact engine that experienced a loss of power event after the ingestion of ice crystals while operating at high altitude during a 1997 Honeywell flight test campaign investigating the turbofan engine ice crystal icing phenomena. The test plan included test points conducted at the known flight test campaign field event pressure altitude and at various pressure altitudes ranging from low to high throughout the engine operating envelope. The test article experienced a loss of power event at each of the altitudes tested. For each pressure altitude test point conducted the ambient static temperature was predicted using a NASA engine icing risk computer model for the given ambient static pressure while maintaining the engine speed.

9. Credit JPL. Photographic copy of drawing, engineering drawing showing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Credit JPL. Photographic copy of drawing, engineering drawing showing structure of Test Stand 'A' (Building 4202/E-3) and its relationship to the Monitor Building or blockhouse (Building 4203/E-4) when a reinforced concrete machinery room was added to the west side of Test Stand 'A' in 1955. California Institute of Technology, Jet Propulsion Laboratory, Plant Engineering 'Electrical Layout - Muroc, Test Stand & Refrigeration Equipment Room,' drawing no. E3/7-0, April 6, 1955. - Jet Propulsion Laboratory Edwards Facility, Test Stand A, Edwards Air Force Base, Boron, Kern County, CA

ROBOTICS IN HAZARDOUS ENVIRONMENTS - REAL DEPLOYMENTS BY THE SAVANNAH RIVER NATIONAL LABORATORY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kriikku, E.; Tibrea, S.; Nance, T.

The Research & Development Engineering (R&DE) section in the Savannah River National Laboratory (SRNL) engineers, integrates, tests, and supports deployment of custom robotics, systems, and tools for use in radioactive, hazardous, or inaccessible environments. Mechanical and electrical engineers, computer control professionals, specialists, machinists, welders, electricians, and mechanics adapt and integrate commercially available technology with in-house designs, to meet the needs of Savannah River Site (SRS), Department of Energy (DOE), and other governmental agency customers. This paper discusses five R&DE robotic and remote system projects.

Analysis of Office/Laboratory Staying Hour and Home Working Hour of Japanese Scientists and Engineers

NASA Astrophysics Data System (ADS)

Ejiri, A.

The second questionnaire for scientists and engineers was carried out in 2007, and status of Japanese scientists and engineers were analyzed and reported. A part of the data was reanalyzed from the viewpoint of work life balance. In particular, office/laboratory staying hour and home working hour were analyzed and dependences on various factors were investigated. It was found that these hours depend on gender, marital status, number of child, employment status and age. In addition, the total hours tend to be kept constant regardless of various factors.

FJ44 Turbofan Engine Test at NASA Glenn Research Center's Aero-Acoustic Propulsion Laboratory

NASA Technical Reports Server (NTRS)

Lauer, Joel T.; McAllister, Joseph; Loew, Raymond A.; Sutliff, Daniel L.; Harley, Thomas C.

2009-01-01

A Williams International FJ44-3A 3000-lb thrust class turbofan engine was tested in the NASA Glenn Research Center s Aero-Acoustic Propulsion Laboratory. This report presents the test set-up and documents the test conditions. Farfield directivity, in-duct unsteady pressures, duct mode data, and phased-array data were taken and are reported separately.