7 CFR 319.37-7 - Postentry quarantine.

Code of Federal Regulations, 2012 CFR

2012-01-01

.... Euonymus spp. (euonymus) All except Canada, Japan, and Europe. Fruit and nut articles listed by common name... located in part or entirely between 90° and 180° East longitude. Nut and fruit articles (see fruit and nut..., and Uruguay. (b) Fruit and nut articles (common names are listed after scientific names). Achras...

7 CFR 319.37-7 - Postentry quarantine.

Code of Federal Regulations, 2014 CFR

2014-01-01

.... Euonymus spp. (euonymus) All except Canada, Japan, and Europe. Fruit and nut articles listed by common name... located in part or entirely between 90° and 180° East longitude. Nut and fruit articles (see fruit and nut..., and Uruguay. (b) Fruit and nut articles (common names are listed after scientific names). Achras...

7 CFR 319.37-7 - Postentry quarantine.

Code of Federal Regulations, 2013 CFR

2013-01-01

.... Euonymus spp. (euonymus) All except Canada, Japan, and Europe. Fruit and nut articles listed by common name... located in part or entirely between 90° and 180° East longitude. Nut and fruit articles (see fruit and nut..., and Uruguay. (b) Fruit and nut articles (common names are listed after scientific names). Achras...

System Proposal for Mass Transit Service Quality Control Based on GPS Data

PubMed Central

Padrón, Gabino; Cristóbal, Teresa; Alayón, Francisco; Quesada-Arencibia, Alexis; García, Carmelo R.

2017-01-01

Quality is an essential aspect of public transport. In the case of regular public passenger transport by road, punctuality and regularity are criteria used to assess quality of service. Calculating metrics related to these criteria continuously over time and comprehensively across the entire transport network requires the handling of large amounts of data. This article describes a system for continuously and comprehensively monitoring punctuality and regularity. The system uses location data acquired continuously in the vehicles and automatically transferred for analysis. These data are processed intelligently by elements that are commonly used by transport operators: GPS-based tracking system, onboard computer and wireless networks for mobile data communications. The system was tested on a transport company, for which we measured the punctuality of one of the routes that it operates; the results are presented in this article. PMID:28621745

System Proposal for Mass Transit Service Quality Control Based on GPS Data.

PubMed

Padrón, Gabino; Cristóbal, Teresa; Alayón, Francisco; Quesada-Arencibia, Alexis; García, Carmelo R

2017-06-16

Quality is an essential aspect of public transport. In the case of regular public passenger transport by road, punctuality and regularity are criteria used to assess quality of service. Calculating metrics related to these criteria continuously over time and comprehensively across the entire transport network requires the handling of large amounts of data. This article describes a system for continuously and comprehensively monitoring punctuality and regularity. The system uses location data acquired continuously in the vehicles and automatically transferred for analysis. These data are processed intelligently by elements that are commonly used by transport operators: GPS-based tracking system, onboard computer and wireless networks for mobile data communications. The system was tested on a transport company, for which we measured the punctuality of one of the routes that it operates; the results are presented in this article.

Autonomous mission management for UAVs using soar intelligent agents

NASA Astrophysics Data System (ADS)

Gunetti, Paolo; Thompson, Haydn; Dodd, Tony

2013-05-01

State-of-the-art unmanned aerial vehicles (UAVs) are typically able to autonomously execute a pre-planned mission. However, UAVs usually fly in a very dynamic environment which requires dynamic changes to the flight plan; this mission management activity is usually tasked to human supervision. Within this article, a software system that autonomously accomplishes the mission management task for a UAV will be proposed. The system is based on a set of theoretical concepts which allow the description of a flight plan and implemented using a combination of Soar intelligent agents and traditional control techniques. The system is capable of automatically generating and then executing an entire flight plan after being assigned a set of objectives. This article thoroughly describes all system components and then presents the results of tests that were executed using a realistic simulation environment.

Optimum angle-cut of collimator for dense objects in high-energy proton radiography

NASA Astrophysics Data System (ADS)

Xu, Hai-Bo; Zheng, Na

2016-02-01

The use of minus identity lenses with an angle-cut collimator can achieve high contrast images in high-energy proton radiography. This article presents the principles of choosing the angle-cut aperture of the collimator for different energies and objects. Numerical simulation using the Monte Carlo code Geant4 has been implemented to investigate the entire radiography for the French test object. The optimum angle-cut apertures of the collimators are also obtained for different energies. Supported by NSAF (11176001) and Science and Technology Developing Foundation of China Academy of Engineering Physics (2012A0202006)

The Journal of Accelerated Learning and Teaching, 1998.

ERIC Educational Resources Information Center

Boy, Nancy Omaha, Ed.

1998-01-01

This document comprises the entire output for the journal for 1998. The first article is in the form of a modified excerpt from an article by Donna I. Ali of the University of Calgary on "Multiple Intelligences and the Writing Process: Some Implications for Teaching." The article investigates why writing is difficult for some and easy for others,…

QM-8 final performance evaluation report: SEALS, volume 4

NASA Technical Reports Server (NTRS)

Nelsen, L. V.

1989-01-01

The Space Shuttle Redesigned Solid Rocket Motor (RSRM) static test of Qualification Motor-8 (QM-8) was conducted. The QM-8 test article was the fifth full-scale, full-duration test, and the third qualification motor to incorporate the redesigned case field joint and nozzle-to-case joint. This was the second static test conducted in the T-97 test facility, which is equipped with actuators for inducing external side loads to a 360 degree external tank (ET) attach ring during test motor operation, and permits heating/cooling of an entire motor. The QM-8 motor was cooled to a temperature which ensured that the maximum propellant mean bulk temperature (PMBT) of 40 F was achieved at firing. All test results are not included, but rather, the performance of the metal case, field joints, and nozzle-to-case joint is addressed. The involvement is studied of the Structural Applications and Structural Design Groups with the QM-8 test which includes: assembly procedures of the field and nozzle-to-case joints, joint leak check results, structural test results, and post-test inspection evaluations.

An automated assay for the assessment of cardiac arrest in fish embryo.

PubMed

Puybareau, Elodie; Genest, Diane; Barbeau, Emilie; Léonard, Marc; Talbot, Hugues

2017-02-01

Studies on fish embryo models are widely developed in research. They are used in several research fields including drug discovery or environmental toxicology. In this article, we propose an entirely automated assay to detect cardiac arrest in Medaka (Oryzias latipes) based on image analysis. We propose a multi-scale pipeline based on mathematical morphology. Starting from video sequences of entire wells in 24-well plates, we focus on the embryo, detect its heart, and ascertain whether or not the heart is beating based on intensity variation analysis. Our image analysis pipeline only uses commonly available operators. It has a low computational cost, allowing analysis at the same rate as acquisition. From an initial dataset of 3192 videos, 660 were discarded as unusable (20.7%), 655 of them correctly so (99.25%) and only 5 incorrectly so (0.75%). The 2532 remaining videos were used for our test. On these, 45 errors were made, leading to a success rate of 98.23%. Copyright © 2016 Elsevier Ltd. All rights reserved.

Ensuring Safe Exploration: Ares Launch Vehicle Integrated Vehicle Ground Vibration Testing

NASA Technical Reports Server (NTRS)

Tuma, M. L.; Chenevert, D. J.

2010-01-01

Integrated vehicle ground vibration testing (IVGVT) will be a vital component for ensuring the safety of NASA's next generation of exploration vehicles to send human beings to the Moon and beyond. A ground vibration test (GVT) measures the fundamental dynamic characteristics of launch vehicles during various phases of flight. The Ares Flight & Integrated Test Office (FITO) will be leading the IVGVT for the Ares I crew launch vehicle at Marshall Space Flight Center (MSFC) from 2012 to 2014 using Test Stand (TS) 4550. MSFC conducted similar GVT for the Saturn V and Space Shuttle vehicles. FITO is responsible for performing the IVGVT on the Ares I crew launch vehicle, which will lift the Orion crew exploration vehicle to low Earth orbit, and the Ares V cargo launch vehicle, which can launch the lunar lander into orbit and send the combined Orionilander vehicles toward the Moon. Ares V consists of a six-engine core stage with two solid rocket boosters and an Earth departure stage (EDS). The same engine will power the EDS and the Ares I second stage. For the Ares IVGVT, the current plan is to test six configurations in three unique test positions inside TS 4550. Position 1 represents the entire launch stack at liftoff (using inert first stage segments). Position 2 consists of the entire launch stack at first stage burn-out (using empty first stage segments). Four Ares I second stage test configurations will be tested in Position 3, consisting of the Upper Stage and Orion crew module in four nominal conditions: J-2X engine ignition, post Launch Abort System (LAS) jettison, critical slosh mass, and J-2X burn-out. Because of long disuse, TS 4550 is being repaired and reactivated to conduct the Ares I IVGVT. The Shuttle-era platforms have been removed and are being replaced with mast climbers that provide ready access to the test articles and can be moved easily to support different positions within the test stand. The electrical power distribution system for TS 4550 was upgraded. Two new cranes will help move test articles at the test stand and at the Redstone Arsenal railhead where first stage segments will be received in 2011. The Hydrodynamic Support systems (HDSs) used for Saturn and Shuttle have been disassembled and evaluated for use during IVGVT. Analyses indicate that the 45-year-old HDSs can be refurbished to support the Ares I IVGVT. An alternate concept for a pneumatic suspension system is also being explored. A decision on which suspension system configuration to use for IVGVT will be made in 2010. In the next three years, the team will complete the updates to TS 4550, upgrade the test and data collection equipment, and finalize the configurations of the test articles to be used in the IVGVT. With NASA's GVT capabilities reestablished, the FITO team will be well positioned to perform similar work on Ares V, the largest exploration launch vehicle NASA has ever built. The GVT effort continues NASA's 50-year commitment to using testing and data analysis for safer, more reliable launch vehicles.

Test and assessment method of Automotive Safety Systems (SSB) particularly to monitor traffic incidents

NASA Astrophysics Data System (ADS)

Pijanowski, B.; Łukjanow, S.; Burliński, R.

2016-09-01

The rapid development of telematics, particularly mobile telephony (GSM), wireless data transmission (GPRS) and satellite positioning (GPS) noticeable in the last decade, resulted in an almost unlimited growth of the possibilities for monitoring of mobile objects. These solutions are already widely used in the so-called “Intelligent Transport Systems” - ITS and affect a significant increase for road safety. The article describes a method of testing and evaluation of Car Safety Systems (Polish abbreviation - SSB) especially for monitoring traffic incidents, such as collisions and accidents. The algorithm of SSB testing process is also presented. Tests are performed on the dynamic test bench, part of which is movable platform with car security system mounted on it. Crash tests with a rigid obstacle are carried out instead of destructive attempts to crash test of the entire vehicle which is expensive. The tested system, depending on the simulated traffic conditions, is mounted in such a position and with the use of components, indicated by the manufacturer for the automotive safety system installation in a vehicle, for which it is intended. Then, the tests and assessments are carried out.

Thermal tests of large recirculation cooling installations for nuclear power plants

NASA Astrophysics Data System (ADS)

Balunov, B. F.; Lychakov, V. D.; Il'in, V. A.; Shcheglov, A. A.; Maslov, O. P.; Rasskazova, N. A.; Rakhimov, R. Z.; Boyarov, R. A.

2017-11-01

The article presents the results from thermal tests of some recirculation installations for cooling air in nuclear power plant premises, including the volume under the containment. The cooling effect in such installations is produced by pumping water through their heat-transfer tubes. Air from the cooled room is blown by a fan through a bundle of transversely finned tubes and is removed to the same room after having been cooled. The finning of tubes used in the tested installations was made of Grade 08Kh18N10T and Grade 08Kh18N10 stainless steels or Grade AD1 aluminum. Steel fins were attached to the tube over their entire length by means of high-frequency welding. Aluminum fins were extruded on a lathe from the external tube sheath into which a steel tube had preliminarily been placed. Although the fin extrusion operation was accompanied by pressing the sheath inner part to the steel tube, tight contact between them over the entire surface was not fully achieved. In view of this, the air gap's thermal resistance coefficient was introduced in calculating the heat transfer between the heat-transferring media. The air gap average thickness was determined from the test results taking into account the gap variation with temperature due to different linear expansion coefficients of steel and aluminum. These tests, which are part of the acceptance tests of the considered installations, were carried out at the NPO TsKTI test facility and were mainly aimed at checking if the obtained thermal characteristics were consistent with the values calculated according to the standard recommendations with introduction, if necessary, of modifications to those recommendations.

MEDICAL PROGRESS: ISOTOPES IN CLINICAL AND EXPERIMENTAL MEDICINE

PubMed Central

Dougherty, Ellsworth C.; Lawrence, John H.

1948-01-01

This is Part II of an article in two parts. Part I appeared in the July issue of California Medicine, and with it were the list of references for the entire article and the Table 1 referred to in the following text. PMID:18731514

THE U.S. EVIRONMENTAL PROTECTION AGENCY ENVIRONMENTAL TECHNOLOGY VERIFICATION PROGRAM—AN OVERVIEW

EPA Science Inventory

This is an article about monitoring technologies in the Environmental Technolgy Verification (ETV) Program which will be published in the Journal of Occupational And Environmental Hygiene. This article gives an overview of the entire ETV program with emphasis on monitoring techn...

Performance of the Satellite Test Assistant Robot in JPL's Space Simulation Facility

NASA Technical Reports Server (NTRS)

Mcaffee, Douglas; Long, Mark; Johnson, Ken; Siebes, Georg

1995-01-01

An innovative new telerobotic inspection system called STAR (the Satellite Test Assistant Robot) has been developed to assist engineers as they test new spacecraft designs in simulated space environments. STAR operates inside the ultra-cold, high-vacuum, test chambers and provides engineers seated at a remote Operator Control Station (OCS) with high resolution video and infrared (IR) images of the flight articles under test. STAR was successfully proof tested in JPL's 25-ft (7.6-m) Space Simulation Chamber where temperatures ranged from +85 C to -190 C and vacuum levels reached 5.1 x 10(exp -6) torr. STAR's IR Camera was used to thermally map the entire interior of the chamber for the first time. STAR also made several unexpected and important discoveries about the thermal processes occurring within the chamber. Using a calibrated test fixture arrayed with ten sample spacecraft materials, the IR camera was shown to produce highly accurate surface temperature data. This paper outlines STAR's design and reports on significant results from the thermal vacuum chamber test.

Bridging the Sciences of Mindfulness and Romantic Relationships.

PubMed

Karremans, Johan C; Schellekens, Melanie P J; Kappen, Gesa

2017-02-01

Research on mindfulness, defined as paying conscious and non-judgmental attention to present-moment experiences, has increased rapidly in the past decade but has focused almost entirely on the benefits of mindfulness for individual well-being. This article considers the role of mindfulness in romantic relationships. Although strong claims have been made about the potentially powerful role of mindfulness in creating better relationships, it is less clear whether, when, and how this may occur. This article integrates the literatures on mindfulness and romantic relationship science, and sketches a theory-driven model and future research agenda to test possible pathways of when and how mindfulness may affect romantic relationship functioning. We review some initial direct and indirect evidence relevant to the proposed model. Finally, we discuss the implications of how studying mindfulness may further our understanding of romantic relationship (dys)functioning, and how mindfulness may be a promising and effective tool in couple interventions.

Test Review: Beal, A. L. (2011). "Insight Test of Cognitive Abilities." Markham, Ontario, Canadian Test Centre

ERIC Educational Resources Information Center

Colp, S. Mitchell; Nordstokke, David W.

2014-01-01

Published by the Canadian Test Centre (CTC), "Insight" represents a group-administered test of cognitive functioning that has been built entirely upon the Cattell-Horn-Carroll (CHC) theoretical framework. "Insight" is intended to be administered by educators and screen entire classrooms for students who present learning…

Space Shuttle Projects

NASA Image and Video Library

1977-02-01

This photograph shows an inside view of a liquid hydrogen tank for the Space Shuttle external tank (ET) Main Propulsion Test Article (MPTA). The ET provides liquid hydrogen and liquid oxygen to the Shuttle's three main engines during the first 8.5 minutes of flight. At 154-feet long and more than 27-feet in diameter, the ET is the largest component of the Space Shuttle, the structural backbone of the entire Shuttle system, and is the only part of the vehicle that is not reusable. The ET is manufactured at the Michoud Assembly Facility near New Orleans, Louisiana, by the Martin Marietta Corporation under management of the Marshall Space Flight Center.

Crossing Borders: Research in Comparative and International Education

ERIC Educational Resources Information Center

Foster, Jesse; Addy, Nii Antiyae; Samoff, Joel

2012-01-01

Published articles permit mapping international and comparative education research. We reviewed 605 articles published 2004-2008 in four major journals. Using title, abstract, and entire text we explored thematic focus, geographic focus, level/type of education studied, method, and funding. The economic, political, and social context of education…

Understanding Measures of Effectiveness in Counterinsurgency Operations

DTIC Science & Technology

2006-05-01

Measure of Success.” The article explained how the Moneyball math of Major League Baseball (MLB) has come to the National Basketball Association ( NBA ...An excerpt from the article stated, “Armed with dazzling equations, NBA front offices are finding entirely new ways to quantify a player’s talent

Paradoxes in Higher Education: Universities versus Academic Colleges

ERIC Educational Resources Information Center

Davidovitch, Nitza; Sinuany-Stern, Zilla; Iram, Yaacov

2013-01-01

This article deals with paradoxical relationships between Israeli universities and colleges and their effect on the system of higher education. The article analyzes the history of the higher-education discourse, ranging from patronizing and domineering relations to collaboration based on the recognition that Israel's entire system of higher…

End-of-Test Performance and Wear Characterization of NASA's Evolutionary Xenon Thruster (NEXT) Long-Duration Test

NASA Technical Reports Server (NTRS)

Shastry, Rohit; Herman, Daniel A.; Soulas, George C.; Patterson, Michael J.

2014-01-01

The NASA's Evolutionary Xenon Thruster (NEXT) program is developing the next-generation solar electric ion propulsion system with significant enhancements beyond the state-of-the-art NASA Solar Electric Propulsion Technology Application Readiness (NSTAR) ion propulsion system to provide future NASA science missions with enhanced capabilities. A Long-Duration Test (LDT) was initiated in June 2005 to validate the thruster service life modeling and to quantify the thruster propellant throughput capability. Testing was recently completed in February 2014, with the thruster accumulating 51,184 hours of operation, processing 918 kg of xenon propellant, and delivering 35.5 MN-s of total impulse.As part of the test termination procedure, a comprehensive performance characterization was performed across the entire NEXT throttle table. This was performed prior to planned repairs of numerous diagnostics that had become inoperable over the course of the test. After completion of these diagnostic repairs in November 2013, a comprehensive end-of-test performance and wear characterization was performed on the test article prior to exposure to atmosphere. These data have confirmed steady thruster performance with minimal degradation as well as mitigation of numerous life limiting mechanisms encountered in the NSTAR design. Component erosion rates compare favorably to pretest predictions based on semi-empirical models used for the thruster service life assessment. Additional data relating to ion beam density profiles, facility backsputter rates, facility backpressure effects on thruster telemetry, and modulation of the neutralizer keeper current are presented as part of the end-of-test characterization. Presently the test article for the NEXT LDT has been exposed to atmosphere and placed within a clean room environment, with post-test disassembly and inspection underway.

Advanced Neuropsychological Diagnostics Infrastructure (ANDI): A Normative Database Created from Control Datasets

PubMed Central

de Vent, Nathalie R.; Agelink van Rentergem, Joost A.; Schmand, Ben A.; Murre, Jaap M. J.; Huizenga, Hilde M.

2016-01-01

In the Advanced Neuropsychological Diagnostics Infrastructure (ANDI), datasets of several research groups are combined into a single database, containing scores on neuropsychological tests from healthy participants. For most popular neuropsychological tests the quantity, and range of these data surpasses that of traditional normative data, thereby enabling more accurate neuropsychological assessment. Because of the unique structure of the database, it facilitates normative comparison methods that were not feasible before, in particular those in which entire profiles of scores are evaluated. In this article, we describe the steps that were necessary to combine the separate datasets into a single database. These steps involve matching variables from multiple datasets, removing outlying values, determining the influence of demographic variables, and finding appropriate transformations to normality. Also, a brief description of the current contents of the ANDI database is given. PMID:27812340

Advanced Neuropsychological Diagnostics Infrastructure (ANDI): A Normative Database Created from Control Datasets.

PubMed

de Vent, Nathalie R; Agelink van Rentergem, Joost A; Schmand, Ben A; Murre, Jaap M J; Huizenga, Hilde M

2016-01-01

In the Advanced Neuropsychological Diagnostics Infrastructure (ANDI), datasets of several research groups are combined into a single database, containing scores on neuropsychological tests from healthy participants. For most popular neuropsychological tests the quantity, and range of these data surpasses that of traditional normative data, thereby enabling more accurate neuropsychological assessment. Because of the unique structure of the database, it facilitates normative comparison methods that were not feasible before, in particular those in which entire profiles of scores are evaluated. In this article, we describe the steps that were necessary to combine the separate datasets into a single database. These steps involve matching variables from multiple datasets, removing outlying values, determining the influence of demographic variables, and finding appropriate transformations to normality. Also, a brief description of the current contents of the ANDI database is given.

Publication bias and the failure of replication in experimental psychology.

PubMed

Francis, Gregory

2012-12-01

Replication of empirical findings plays a fundamental role in science. Among experimental psychologists, successful replication enhances belief in a finding, while a failure to replicate is often interpreted to mean that one of the experiments is flawed. This view is wrong. Because experimental psychology uses statistics, empirical findings should appear with predictable probabilities. In a misguided effort to demonstrate successful replication of empirical findings and avoid failures to replicate, experimental psychologists sometimes report too many positive results. Rather than strengthen confidence in an effect, too much successful replication actually indicates publication bias, which invalidates entire sets of experimental findings. Researchers cannot judge the validity of a set of biased experiments because the experiment set may consist entirely of type I errors. This article shows how an investigation of the effect sizes from reported experiments can test for publication bias by looking for too much successful replication. Simulated experiments demonstrate that the publication bias test is able to discriminate biased experiment sets from unbiased experiment sets, but it is conservative about reporting bias. The test is then applied to several studies of prominent phenomena that highlight how publication bias contaminates some findings in experimental psychology. Additional simulated experiments demonstrate that using Bayesian methods of data analysis can reduce (and in some cases, eliminate) the occurrence of publication bias. Such methods should be part of a systematic process to remove publication bias from experimental psychology and reinstate the important role of replication as a final arbiter of scientific findings.

7 CFR 301.75-2 - General prohibitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Regulations § 301.75-2 General prohibitions. (a) Regulated articles may not be moved interstate from a... with § 301.75-4 if less than an entire State is designated as a quarantined area. Regulated articles may be moved in accordance with the regulations in § 301.75-9 for scientific or experimental purposes...

Online Student Orientation in Higher Education: A Developmental Study

ERIC Educational Resources Information Center

Cho, Moon-Heum

2012-01-01

Although orientation for online students is important to their success, little information about how to develop an online student orientation (OSO) has appeared in the literature; therefore, the purpose of this article was to describe the entire process of developing an OSO. This article describes the analysis, design, development, and evaluation…

The Cable Fable.

ERIC Educational Resources Information Center

Kalba, Kas, Ed.

1972-01-01

An entire issue of the "Yale Review of Law and Social Action" has been devoted to 12 articles providing views on potential benefits and pitfalls of cable television in contrast to the picture provided by the Sloan Commission Report. The goal further unifying these articles is that of waging the argument for an expanded cable television policy.…

7 CFR 301.75-2 - General prohibitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Regulations § 301.75-2 General prohibitions. (a) Regulated articles may not be moved interstate from a... with § 301.75-4 if less than an entire State is designated as a quarantined area. Regulated articles may be moved in accordance with the regulations in § 301.75-9 for scientific or experimental purposes...

New Models for Initial Teacher Education in Scotland

ERIC Educational Resources Information Center

Kibble, Bob

2012-01-01

In this article, the author responds to the recent article by Lynne Bianchi commenting on the Donaldson report, "Teaching Scotland's future" (Donaldson, 2011). He agrees that the Donaldson report has indeed been a catalyst to drive change across the entire landscape of initial teacher education (ITE) in Scotland. In fact, not only ITE:…

When Is Creativity? Intrinsic Motivation and Autonomy in Children's Artmaking

ERIC Educational Resources Information Center

Jaquith, Diane B.

2011-01-01

The title of this article borrows loosely from the philosopher Nelson Goodman, whose classic essay "When is Art" addresses context and symbolic function. The discussion in this article concerns an entirely different matter: identifying moments when a learner's creativity is sparked in school art programs. The word "creativity" usually enters…

Flowfield Analysis of a Small Entry Probe (SPRITE) Tested in an Arc Jet

NASA Technical Reports Server (NTRS)

Prabhu, Dinesh K.

2012-01-01

A novel concept of small size (diameter less than 15 inches) entry probes named SPRITE (Small Probe Re-entry Investigation for TPS Engineering) has been developed at NASA Ames Research Center (ARC). These flight probes have on-board data acquisition systems that have also been developed in parallel at NASA ARC by Greg Swanson1. Flight probes of this size facilitate testing over a wide range of conditions in arc jets available at NASA ARC, thereby fulfilling a 'test what you fly' paradigm. As indicated by the acronym, these probes, with suitably tailored trajectories, are primarily meant to be robotic flight test beds for TPS materials, although the design is flexible enough to accommodate additional objectives of flight-testing other vehicle subsystems. A first step towards establishing the feasibility of the SPRITE concept is to arc-jet test fully instrumented models at flight scale. In a follow-on to the Large-Scale Article Tests (LSAT2) performed in the 60 MW Interaction Heating Facility (IHF) in late 2008/early 2009, a full-scale model of Deep Space-2 (DS23) made of red oak was tested in the 20 MW Aerodynamic Heating Facility (AHF). There were no issues with mass capture by the diffuser for blunt bodies of roughly 15 inches diameter tested in the 18-inch nozzle of the AHF. Building on this initial success, two identical test articles - SPRITE-T1-1 and SPRITE-T1-2 (T1 indicating the choice of back shell geometry) - were fabricated, and one of them, SPRITE-T1-1, was tested in the AHF recently. Both these test articles, 14 inches in diameter, have a 45deg sphere-cone (like DS2) made of PICA bonded on to a 1/8th inch thick aluminum shell using RTV. The aft portion of the test article is a conical frustum (15deg cone angle) with LI-2200 bonded on to the aluminum shell. Each model is fully instrumented with: (a) thermocouples imbedded in plugs in the heat shield, (b) thermocouples bonded to the aluminum substructure; the thermocouples are distributed over the entire shell, and (c) a few strain gages. Data from some of the thermocouples and gages are acquired by the on-board data acquisition system (DAS), while data from the others are routed to the facility-provided DAS, thereby enabling a cross check on the in situ measurement capability. as inputs to v2.6.1 of the in-house materials thermal response code, FIAT

Invited review article: Large ring lasers for rotation sensing.

PubMed

Schreiber, Karl Ulrich; Wells, Jon-Paul R

2013-04-01

Over the last two decades a series of large ring laser gyroscopes have been built having an unparalleled scale factor. These upscaled devices have improved the sensitivity and stability for rotation rate measurements by six orders of magnitude when compared to previous commercial developments. This progress has made possible entirely new applications of ring laser gyroscopes in the fields of geophysics, geodesy, and seismology. Ring lasers are currently the only viable measurement technology, which is directly referenced to the instantaneous rotation axis of the Earth. The sensor technology is rapidly developing. This is evidenced by the first experimentally viable proposals to make terrestrial tests of general relativistic effects such as the frame dragging of the rotating Earth.

A step-by-step solution for embedding user-controlled cines into educational Web pages.

PubMed

Cornfeld, Daniel

2008-03-01

The objective of this article is to introduce a simple method for embedding user-controlled cines into a Web page using a simple JavaScript. Step-by-step instructions are included and the source code is made available. This technique allows the creation of portable Web pages that allow the user to scroll through cases as if seated at a PACS workstation. A simple JavaScript allows scrollable image stacks to be included on Web pages. With this technique, you can quickly and easily incorporate entire stacks of CT or MR images into online teaching files. This technique has the potential for use in case presentations, online didactics, teaching archives, and resident testing.

Advances in Polyhydroxyalkanoate (PHA) Production.

PubMed

Koller, Martin

2017-11-02

This editorial paper provides a synopsis of the contributions to the Bioengineering special issue "Advances in Polyhydroxyalkanoate (PHA) Production". It illustrates the embedding of the issue's individual research articles in the current global research and development landscape related to polyhydroxyalkanoates (PHA). The article shows how these articles are interrelated to each other, reflecting the entire PHA process chain including strain selection, metabolic and genetic considerations, feedstock evaluation, fermentation regimes, process engineering, and polymer processing towards high-value marketable products.

The costs and benefits of mind-wandering: a review.

PubMed

Mooneyham, Benjamin W; Schooler, Jonathan W

2013-03-01

Substantial evidence suggests that mind-wandering typically occurs at a significant cost to performance. Mind-wandering-related deficits in performance have been observed in many contexts, most notably reading, tests of sustained attention, and tests of aptitude. Mind-wandering has been shown to negatively impact reading comprehension and model building, impair the ability to withhold automatized responses, and disrupt performance on tests of working memory and intelligence. These empirically identified costs of mind-wandering have led to the suggestion that mind-wandering may represent a pure failure of cognitive control and thus pose little benefit. However, emerging evidence suggests that the role of mind-wandering is not entirely pernicious. Recent studies have shown that mind-wandering may play a crucial role in both autobiographical planning and creative problem solving, thus providing at least two possible adaptive functions of the phenomenon. This article reviews these observed costs and possible functions of mind-wandering and identifies important avenues of future inquiry.

International ring trial for the validation of an event-specific Golden Rice 2 quantitative real-time polymerase chain reaction method.

PubMed

Jacchia, Sara; Nardini, Elena; Bassani, Niccolò; Savini, Christian; Shim, Jung-Hyun; Trijatmiko, Kurniawan; Kreysa, Joachim; Mazzara, Marco

2015-05-27

This article describes the international validation of the quantitative real-time polymerase chain reaction (PCR) detection method for Golden Rice 2. The method consists of a taxon-specific assay amplifying a fragment of rice Phospholipase D α2 gene, and an event-specific assay designed on the 3' junction between transgenic insert and plant DNA. We validated the two assays independently, with absolute quantification, and in combination, with relative quantification, on DNA samples prepared in haploid genome equivalents. We assessed trueness, precision, efficiency, and linearity of the two assays, and the results demonstrate that both the assays independently assessed and the entire method fulfill European and international requirements for methods for genetically modified organism (GMO) testing, within the dynamic range tested. The homogeneity of the results of the collaborative trial between Europe and Asia is a good indicator of the robustness of the method.

Low and High Frequency Models of Response Statistics of a Cylindrical Orthogrid Vehicle Panel to Acoustic Excitation

NASA Technical Reports Server (NTRS)

Smith, Andrew; LaVerde, Bruce; Teague, David; Gardner, Bryce; Cotoni, Vincent

2010-01-01

This presentation further develops the orthogrid vehicle panel work. Employed Hybrid Module capabilities to assess both low/mid frequency and high frequency models in the VA One simulation environment. The response estimates from three modeling approaches are compared to ground test measurements. Detailed Finite Element Model of the Test Article -Expect to capture both the global panel modes and the local pocket mode response, but at a considerable analysis expense (time & resources). A Composite Layered Construction equivalent global stiffness approximation using SEA -Expect to capture response of the global panel modes only. An SEA approximation using the Periodic Subsystem Formulation. A finite element model of a single periodic cell is used to derive the vibroacoustic properties of the entire periodic structure (modal density, radiation efficiency, etc. Expect to capture response at various locations on the panel (on the skin and on the ribs) with less analysis expense

Enabling the Public to Experience Science from Beginning to End (Invited)

NASA Astrophysics Data System (ADS)

Trouille, L.; Chen, Y.; Lintott, C.; Lynn, S.; Simmons, B.; Smith, A.; Tremonti, C.; Whyte, L.; Willett, K.; Zevin, M.; Science Team; Moderator Team, G.

2013-12-01

In this talk we present the results of an experiment in collaborative research and article writing within the citizen science context. During July-September 2013, astronomers and the Zooniverse team ran Galaxy Zoo Quench (quench.galaxyzoo.org), investigating the mechanism(s) that recently and abruptly shut off star formation in a sample of post-quenched galaxies. Through this project, the public had the opportunity to experience the entire process of science, including galaxy classification, reading background literature, data analysis, discussion, debate, drawing conclusions, and writing an article to submit to a professional journal. The context was galaxy evolution, however, the lessons learned are applicable across the disciplines. The discussion will focus on how to leverage online tools to authentically engage the public in the entire process of science.

Influence of social mixing and group size on skin lesions and mounting in organic entire male pigs.

PubMed

Thomsen, R; Edwards, S A; Rousing, T; Labouriau, R; Sørensen, J T

2016-07-01

Alternatives to surgical castration are needed, due to stress and pain caused by castration of male pigs. One alternative is production of entire male pigs. However, changed behaviour of entire males compared with castrated males might adversely affect the welfare of entire males and changes in management procedures and production system might be needed. Elements from the organic pig production system might be beneficial in this aspect. The aim of this article is to investigate the effect of grouping strategy including social mixing and group size on levels of mounting behaviour and skin lesions, hypothesising that procedures that disrupt the social stability (e.g. regrouping) will have a larger negative effect in small groups compared with large groups. Approximately 1600 organic entire male pigs of the breed (Landrace×Yorkshire)×Duroc were reared in parallel in five organic herds, distributed across four batches in a 2×2 factorial design in order to test the influence of social mixing (presence or absence of social mixing at relocation) and group size (15 and 30 animals). Animals were able to socialise with piglets from other litters during the lactation period, and were all mixed across litters at weaning. A second mixing occurred at insertion to fattening pens for pigs being regrouped. Counting of skin lesions (1348 or 1124 pigs) and registration of mounting behaviour (1434 or 1258 pigs) were done on two occasions during the experimental period. No interactive effects were found between social mixing and group size on either skin lesions or mounting frequency. Herd differences were found for both mounting frequency and number of skin lesions. No association between skin lesions and mounting were revealed. Social mixing and group size were shown as interacting effects with herds on mounting frequency (P<0.0001), but with no consistent pattern across all herds. In addition, no effect of social mixing was found on mean number of skin lesions, but more lesions were observed in large groups (P<0.036). This could indicate that keeping entire male pigs in groups of 30 animals as compared with smaller groups of 15 may marginally decrease the welfare of these animals.

A New Approach to Environmental Education.

ERIC Educational Resources Information Center

Weidner, Edward W.

1981-01-01

The entire higher education program at the University of Wisconsin-Green Bay focuses upon problems associated with people and the environment. This article describes the program's goals, implementation and benefits. (WB)

First Novels: Fall Firsts

ERIC Educational Resources Information Center

Witherell, Mary

2010-01-01

This article presents a list of new novels. The entire compilation is grouped into pop fiction, literary, thrillers, Christian fiction, mystery, romance, historical fiction, street lit, science fiction/fantasy/horror, and graphic novels.

Those Were Some of the Hottest Days of My Life: The Genesis of SCOLT

ERIC Educational Resources Information Center

Swanson, Pete

2015-01-01

The following article recounts the creation and development of the Southern Conference on Language Teaching (SCOLT) through the words of one of its founders, Dr. Herman Bostick. The article is not intended to tell the entire history of the founding of the organization, nor the full story of Dr. Bostick's contributions to the civil rights movement…

Advances in Polyhydroxyalkanoate (PHA) Production

PubMed Central

2017-01-01

This editorial paper provides a synopsis of the contributions to the Bioengineering special issue “Advances in Polyhydroxyalkanoate (PHA) Production”. It illustrates the embedding of the issue’s individual research articles in the current global research and development landscape related to polyhydroxyalkanoates (PHA). The article shows how these articles are interrelated to each other, reflecting the entire PHA process chain including strain selection, metabolic and genetic considerations, feedstock evaluation, fermentation regimes, process engineering, and polymer processing towards high-value marketable products. PMID:29099065

Apparatus and method for skin packaging articles

NASA Technical Reports Server (NTRS)

Madsen, B.; Pozsony, E. R.; Collin, E. E. (Inventor)

1973-01-01

A system for skin packaging articles including a loading zone for positioning articles to be packaged upon a substrate, a thermoplastic film heating and vacuum operated skin packaging zone for covering the articles with film laminated to the substrate and a slitting zone for separating and trimming the individual skin packaged articles. The articles are passed to the successive zones. The loading zone may be adapted for conveyorized instead of hand loading. In some cases, where only transverse cutting of the film web is necessary, it may be desirable to eliminate the slitting zone and remove the skin packaged article or articles directly from the packaging zone. A conveniently located operating panel contains controls for effecting automatic, semiautomatic or manual operation of the entire system of any portions in any manner desired.

Exploration of Relationship Between Stress and Spirituality Characteristics of Male and Female Engineering Students: A Comprehensive Study.

PubMed

Yadav, Radha; Khanna, Ashu; Singh, Dharmendra

2017-04-01

This observational paper endeavours to recognize the connection between spirituality and stress. Four types of indicators are utilized for the estimation of anxiety, vis-à-vis, behavioural indicators, emotional indicators, sleep indicators and personal habits. As per pre-documented theory, if spirituality is high within an individual, then his/her stress will be low and vice versa. In college, the stress of education and scoring grades influences the understudy. Information is gathered through a survey in the light of spirituality index and stress index. Findings prove that the indicators of the stress are more visible in female students. Apart from this, there has been not much substantial study in the area of stress and spirituality among college students. Hence, the main purpose of this study was to discuss the various types of stress and effects of spirituality on the engineering students belonging to the age group of 21-26 years, prioritizing the indicators of stress as per the gender of students. The entire study constituted of a sample group of 200 participants, and for the entire process, correlation analysis was used to find the relative relation between spirituality and stress among girls and boys. T test is used for rejection of the null hypothesis. The article focuses on the current issues that students have been facing in the twenty-first century. Result of the study showed that there is a negative relationship between the spirituality and stress of male and female students. Moreover, the article provides unique contribution to the literature and also offers suggestions for generating new research ideas that can be used to ameliorate the problems that plague individuals and organizations in today's world. This is the first article which covers the spirituality and stress of the engineering student and discusses the impact on young adults, as well as highlighting certain ways to overcome stress and enhance spirituality.

Applying activity-based costing to healthcare settings.

PubMed

Canby, J B

1995-02-01

Activity-based costing (ABC) focuses on processes that drive cost. By tracing healthcare activities back to events that generate cost, a more accurate measurement of financial performance is possible. This article uses ABC principles and techniques to determine costs associated with the x-ray process in a midsized outpatient clinic. The article also provides several tips for initiating an ABC cost system for an entire healthcare organization.

Artificial intelligence: Deep neural reasoning

NASA Astrophysics Data System (ADS)

Jaeger, Herbert

2016-10-01

The human brain can solve highly abstract reasoning problems using a neural network that is entirely physical. The underlying mechanisms are only partially understood, but an artificial network provides valuable insight. See Article p.471

The fabrication of a multi-spectral lens array and its application in assisting color blindness

NASA Astrophysics Data System (ADS)

Di, Si; Jin, Jian; Tang, Guanrong; Chen, Xianshuai; Du, Ruxu

2016-01-01

This article presents a compact multi-spectral lens array and describes its application in assisting color-blindness. The lens array consists of 9 microlens, and each microlens is coated with a different color filter. Thus, it can capture different light bands, including red, orange, yellow, green, cyan, blue, violet, near-infrared, and the entire visible band. First, the fabrication process is described in detail. Second, an imaging system is setup and a color blindness testing card is selected as the sample. By the system, the vision results of normal people and color blindness can be captured simultaneously. Based on the imaging results, it is possible to be used for helping color-blindness to recover normal vision.

Fundamentals in Biostatistics for Research in Pediatric Dentistry: Part I - Basic Concepts.

PubMed

Garrocho-Rangel, J A; Ruiz-Rodríguez, M S; Pozos-Guillén, A J

The purpose of this report was to provide the reader with some basic concepts in order to better understand the significance and reliability of the results of any article on Pediatric Dentistry. Currently, Pediatric Dentists need the best evidence available in the literature on which to base their diagnoses and treatment decisions for the children's oral care. Basic understanding of Biostatistics plays an important role during the entire Evidence-Based Dentistry (EBD) process. This report describes Biostatistics fundamentals in order to introduce the basic concepts used in statistics, such as summary measures, estimation, hypothesis testing, effect size, level of significance, p value, confidence intervals, etc., which are available to Pediatric Dentists interested in reading or designing original clinical or epidemiological studies.

Unsupervised Outlier Profile Analysis

PubMed Central

Ghosh, Debashis; Li, Song

2014-01-01

In much of the analysis of high-throughput genomic data, “interesting” genes have been selected based on assessment of differential expression between two groups or generalizations thereof. Most of the literature focuses on changes in mean expression or the entire distribution. In this article, we explore the use of C(α) tests, which have been applied in other genomic data settings. Their use for the outlier expression problem, in particular with continuous data, is problematic but nevertheless motivates new statistics that give an unsupervised analog to previously developed outlier profile analysis approaches. Some simulation studies are used to evaluate the proposal. A bivariate extension is described that can accommodate data from two platforms on matched samples. The proposed methods are applied to data from a prostate cancer study. PMID:25452686

Genetics Education in Nurse Residency Programs: A Natural Fit.

PubMed

Hamilton, Nalo M; Stenman, Christina W; Sang, Elaine; Palmer, Christina

2017-08-01

Scientific advances are shedding light on the genetic underpinning of common diseases. With such insight, the entire health care team is faced with the need to address patient questions regarding genetic risk, testing, and the psychosocial aspects of genetics information. Nurses are in a prime position to help with patient education about genetic conditions, yet they often lack adequate genetics education within their nursing curriculum to address patient questions and provide resources. One mechanism to address this knowledge deficit is the incorporation of a genetics-based curriculum into nurse residency programs. This article describes a novel genetics-based curriculum designed and implemented in the UCLA Health System Nurse Residency Program. J Contin Educ Nurs. 2017;48(8):379-384. Copyright 2017, SLACK Incorporated.

Automated Text Data Mining Analysis of Five Decades of Educational Leadership Research Literature: Probabilistic Topic Modeling of "EAQ" Articles From 1965 to 2014

ERIC Educational Resources Information Center

Wang, Yinying; Bowers, Alex J.; Fikis, David J.

2017-01-01

Purpose: The purpose of this study is to describe the underlying topics and the topic evolution in the 50-year history of educational leadership research literature. Method: We used automated text data mining with probabilistic latent topic models to examine the full text of the entire publication history of all 1,539 articles published in…

"If I Had to Pick Any Subject, It Wouldn't Be Maths": Foundations for Engagement with Mathematics during the Middle Years

ERIC Educational Resources Information Center

Attard, Catherine

2013-01-01

This article is a report on a longitudinal case study that investigated the problem of lowered engagement with mathematics and students' perspectives of the factors that influenced their engagement during the middle years of schooling. The article provides a synthesis of the entire study and a summary of its findings. In order to address the…

Maritime security report

DOT National Transportation Integrated Search

1996-04-01

The first article in this report deals with the rising theft and in-transit hijacking of entire containers and trailers in port cities and adjacent areas in the United States. Cargo thefts are occurring most frequently in Florida, California, New Yor...

Structural Qualification Testing of the WindSat Payload Using Sine Bursts Near Structural Resonance

NASA Technical Reports Server (NTRS)

Pontius, Jim; Barnes, Donald; Broduer, Steve (Technical Monitor)

2001-01-01

Sine burst tests are often used for structural qualification of space flight hardware. In most instances, the driving frequency of the shaker is specified far below the structure's first resonant mode, such that the entire test article sees uniform acceleration. For large structures, this limits qualification testing to lower parts of the structure, or else it over-tests the lower structure to achieve qualification of the upper structure. The WindSat payload, a 10.5 foot tall graphite/epoxy, titanium, and aluminum radiometer, experiences accelerations at the six foot diameter reflector nearly four times that at the spacecraft interface. Due to size of the payload, the number of bonded joints, and the lightweight reflector support structure design and construction, using static pull testing to qualify all of the bonded joints in the upper structure would result in large, expensive, and extensive test fixturing. Sine burst testing near the first two structural resonant modes was performed on the WindSat payload to achieve the correct load factor distribution up the stack for structural qualification. In this presentation, how finite element method (FEM) sine burst predictions were used in conjunction with low level random and sine burst tests to achieve correct qualification test load factor distribution on the WindSat payload is discussed. Also presented is the risk mitigation approach for using the uncorrelated FEM in this procedure.

Demand for command: responding to technological risks and scientific uncertainties.

PubMed

Stokes, Elen

2013-01-01

This article seeks to add to current theories of new governance by highlighting the predicament facing regulators and regulatees when dealing with new technologies. Using nanotechnologies as a study, it shows that new modes of governance (as opposed to traditional coercive, or command and control regulation) offer promising solutions to highly complex, uncertain, and contested problems of risk, such as those associated with new technologies. In this regard, nanotechnologies provide a useful test bed for the ambitions of newer, better modes of governance because there are not yet any fixed ideas about the appropriate course of action. The article suggests, however, that examples of new governance are less prominent than perhaps expected. Drawing on empirical data, it argues that, when faced with considerable epistemological, political, economic, and ethical uncertainties, regulatory stakeholders often exhibit a preference for more conventional command methods of regulation. That is not to say that new governance is entirely absent from regulatory policies on nanotechnologies, but that new governance is emerging in perhaps more subtle ways than the scholarly and policy literature predicted.

Investigation into Hybrid Rockets and Other Cost-Effective Propulsion System Options for Small Satellites

DTIC Science & Technology

1996-05-01

8-7 COMPLETE TEXT OF THESIS ROCKET PROPULSION FUNDEMENTALS EXPERIMENTAL DATA (MICROSOFT EXCEL FILES) 4 ANALYSIS WORKSHEETS (MATHSOFT MATHCAD FILES...up and running. At ~413,000, this represents a very small investment considering it encompasses the entire program. Similar programs run at... investment would be -needed along with over two man-years of effort. However, this is for the first flight article. Subsequent flight articles of identical

Intersegmental Articulation.

ERIC Educational Resources Information Center

CATESOL Journal, 1996

1996-01-01

This English-as-a-Second Language (ESL) journal periodically devotes entire issues to specific themes. The theme of this issue is "Intersegmental Articulation" (especially in California schools). Articles include: "Why Is ESL a Burning Issue?" (Robby Ching, Anne Ediger, Debbie Poole); "Challenges Facing California ESL…

Performance map of a cluster detection test using extended power

PubMed Central

2013-01-01

Background Conventional power studies possess limited ability to assess the performance of cluster detection tests. In particular, they cannot evaluate the accuracy of the cluster location, which is essential in such assessments. Furthermore, they usually estimate power for one or a few particular alternative hypotheses and thus cannot assess performance over an entire region. Takahashi and Tango developed the concept of extended power that indicates both the rate of null hypothesis rejection and the accuracy of the cluster location. We propose a systematic assessment method, using here extended power, to produce a map showing the performance of cluster detection tests over an entire region. Methods To explore the behavior of a cluster detection test on identical cluster types at any possible location, we successively applied four different spatial and epidemiological parameters. These parameters determined four cluster collections, each covering the entire study region. We simulated 1,000 datasets for each cluster and analyzed them with Kulldorff’s spatial scan statistic. From the area under the extended power curve, we constructed a map for each parameter set showing the performance of the test across the entire region. Results Consistent with previous studies, the performance of the spatial scan statistic increased with the baseline incidence of disease, the size of the at-risk population and the strength of the cluster (i.e., the relative risk). Performance was heterogeneous, however, even for very similar clusters (i.e., similar with respect to the aforementioned factors), suggesting the influence of other factors. Conclusions The area under the extended power curve is a single measure of performance and, although needing further exploration, it is suitable to conduct a systematic spatial evaluation of performance. The performance map we propose enables epidemiologists to assess cluster detection tests across an entire study region. PMID:24156765

[Gender differences of psychological, nutritional, and physical fitness variables influencing obesity/overweight in Austrian children and adolescents].

PubMed

Ardelt-Gattinger, Elisabeth; Ring-Dimitriou, Susanne; Hofmann, Johannes; Paulmichl, Katharina; Zsoldos, Fanni; Weghuber, Daniel

2016-03-01

Eating behavior and physical activity behavior are under the control of certain cognitive patterns. 6600 adults and 4400 children/adolescents (8-18 years) were tested with the Obesity Diagnostics and Evaluation System (AD-EVA). Potentially significant gender differences will be detailed for the entire juvenile cohort, the subgroup of obese children/adolescents as compared to the adult cohort in this article.Among all the subscales tested, obese girls primarily showed significantly higher values of (preclinical) eating disorders than boys. These data are relevant for both prevention and health promotion.No significant differences were found in regard to sports motivation. This warrants facilitation of physical activity for both genders. Further, a male predilection for "Snacks" and "High-fat food" that could be found in the total representative study group, could not be verified in the subgroup of obese girls and boys, thus suggesting a similarily unhealthy eating behavior in both genders of juvenility.

[What is the methodological quality of articles on therapeutic procedures published in Cirugía Española?].

PubMed

Manterola, Carlos; Busquets, Juli; Pascual, Marta; Grande, Luis

2006-02-01

The aim of this study was to determine the methodological quality of articles on therapeutic procedures published in Cirugía Española and to study its association with the publication year, center, and subject-matter. A bibliometric study that included all articles on therapeutic procedures published in Cirugía Española between 2001 and 2004 was performed. All kinds of clinical designs were considered, excluding editorials, review articles, letters to editor, and experimental studies. The variables analyzed were: year of publication, center, design, and methodological quality. Methodological quality was determined by a valid and reliable scale. Descriptive statistics (calculation of means, standard deviation and medians) and analytical statistics (Pearson's chi2, nonparametric, ANOVA and Bonferroni tests) were used. A total of 244 articles were studied (197 case series [81%], 28 cohort studies [12%], 17 clinical trials [7%], 1 cross sectional study and 1 case-control study [0.8%]). The studies were performed mainly in Catalonia and Murcia (22% and 16%, respectively). The most frequent subject areas were soft tissue and hepatobiliopancreatic surgery (23% and 19%, respectively). The mean and median of the methodological quality score calculated for the entire series was 10.2 +/- 3.9 points and 9.5 points, respectively. Methodological quality significantly increased by publication year (p < 0.001). An association between methodological quality and subject area was observed but no association was detected with the center performing the study. The methodological quality of articles on therapeutic procedures published in Cirugía Española between 2001 and 2004 is low. However, a statistically significant trend toward improvement was observed.

Rotor Aerodynamics in Ground Effect at Low Advance Ratios.

DTIC Science & Technology

1982-07-27

the rotor wake flows entirely downstream. At test conditions were the recirculating flow or ground vortex is present there are marked departures...ILLUSTRATIONS Figure Page 1 Cross Section of Test Facilty 12 2 Overall View of Test Facility and Rotor Model 13 3 Flow Pattern in Ground Vortex Regime, (v...entirely flowing downstream splits and a portion of the rotor wake flows forward (upstream) and then recirculates through the rotor or forms a vortex or

Foreword

Treesearch

H. Michael Rauscher; Richard E. Plant; Alan J. Thomson; Mark J. Twery

2000-01-01

This article includes the central themes of the keynote speakers for the scientific conference "The Application of Scientific Knowledge to Decisionmaking in Managing Forest Ecosystems." This International Union of Forestry Research Organizations (IUFRO) conference presented the latest developments concerning the entire range of topics dealing with ecosystem...

Investigating Interdimensional Relationships

ERIC Educational Resources Information Center

Valentine, Keri Duncan

2017-01-01

The phrase "interdimensional relationships" may conjure images of UFOs, alien beings, wormholes, and even mystical powers. These notions of interdimensionality were not out of bounds in the middle school learners' experiences described in this article. However, these notions do not entirely capture the mathematical relationships…

The Brain.

ERIC Educational Resources Information Center

Hubel, David H.

1979-01-01

This article on the brain is part of an entire issue about neurobiology and the question of how the human brain works. The brain as an intricate tissue composed of cells is discussed based on the current knowledge and understanding of its composition and structure. (SA)

Monitoring the Environment

ERIC Educational Resources Information Center

Heins, Conrad F.; And Others

1975-01-01

New ways of obtaining environmental data are being developed to meet the demand for comprehensive, accurate, and timely information on the environment. This article examines four developments that are transforming the entire field of environmental measurement: spectroscopy; satellite transmission of environmental data; remote sensing; and…

Content-Based Instruction.

ERIC Educational Resources Information Center

CATESOL Journal, 1992

1992-01-01

This English-as-a-Second Language (ESL) journal periodical devotes entire issues to specific issues. The theme of this issue is "Content-Base Instruction." Articles include: "Syllabus Design in Content-Based Instruction" (David E. Eskey); "How Relevant Is Relevance?: An Examination of Student Needs, Interests, and…

If the results of an article are noteworthy, read the entire article; do not rely on the abstract alone.

PubMed

Dal-Ré, R; Castell, M V; García-Puig, J

2015-11-01

Clinicians typically update their knowledge by reading articles on the Internet. Easy access to the articles' abstracts and a lack of time to access other information sources creates a risk that therapeutic or diagnostic decisions will be made after reading just the abstracts. Occasionally, however, the abstracts of articles from clinical trials that have not obtained statistically significant differences in the primary study endpoint have reported other positive results, for example, of a secondary endpoint or a subgroup analysis. The article, however, correctly reports all results, including those of the primary endpoint. In the abstract, the safety information of the experimental treatment is usually deficient. The whole article should be read if a clinical decision is to be made. Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Medicina Interna (SEMI). All rights reserved.

Welding of gamma titanium aluminide alloys

NASA Technical Reports Server (NTRS)

Smashey, Russell W. (Inventor); Snyder, John H. (Inventor); Kelly, Thomas J. (Inventor); Sheranko, Ronald L. (Inventor)

1998-01-01

An article made of a gamma titanium aluminide alloy is welded, as for example in the weld repair of surface cracks, by removing foreign matter from the area to be welded, first stress relieving the article, cooling the entire article to a welding temperature of from about 1000.degree. F. to about 1400.degree. F., welding a preselected region in an inert atmosphere at the welding temperature, and second stress relieving the article. Welding is preferably accomplished by striking an arc in the preselected region so as to locally melt the alloy in the preselected region, providing a filler metal having the same composition as the gamma titanium aluminide alloy of the article, and feeding the filler metal into the arc so that the filler metal is melted and fused with the article to form a weldment upon solidification.

Method and platform standardization in MRM-based quantitative plasma proteomics.

PubMed

Percy, Andrew J; Chambers, Andrew G; Yang, Juncong; Jackson, Angela M; Domanski, Dominik; Burkhart, Julia; Sickmann, Albert; Borchers, Christoph H

2013-12-16

There exists a growing demand in the proteomics community to standardize experimental methods and liquid chromatography-mass spectrometry (LC/MS) platforms in order to enable the acquisition of more precise and accurate quantitative data. This necessity is heightened by the evolving trend of verifying and validating candidate disease biomarkers in complex biofluids, such as blood plasma, through targeted multiple reaction monitoring (MRM)-based approaches with stable isotope-labeled standards (SIS). Considering the lack of performance standards for quantitative plasma proteomics, we previously developed two reference kits to evaluate the MRM with SIS peptide approach using undepleted and non-enriched human plasma. The first kit tests the effectiveness of the LC/MRM-MS platform (kit #1), while the second evaluates the performance of an entire analytical workflow (kit #2). Here, these kits have been refined for practical use and then evaluated through intra- and inter-laboratory testing on 6 common LC/MS platforms. For an identical panel of 22 plasma proteins, similar concentrations were determined, regardless of the kit, instrument platform, and laboratory of analysis. These results demonstrate the value of the kit and reinforce the utility of standardized methods and protocols. The proteomics community needs standardized experimental protocols and quality control methods in order to improve the reproducibility of MS-based quantitative data. This need is heightened by the evolving trend for MRM-based validation of proposed disease biomarkers in complex biofluids such as blood plasma. We have developed two kits to assist in the inter- and intra-laboratory quality control of MRM experiments: the first kit tests the effectiveness of the LC/MRM-MS platform (kit #1), while the second evaluates the performance of an entire analytical workflow (kit #2). In this paper, we report the use of these kits in intra- and inter-laboratory testing on 6 common LC/MS platforms. This article is part of a Special Issue entitled: Standardization and Quality Control in Proteomics. © 2013.

Design and Fabrication of Oxygen/RP-2 Multi-Element Oxidizer-Rich Staged Combustion Thrust Chamber Injectors

NASA Technical Reports Server (NTRS)

Garcia, C. P.; Medina, C. R.; Protz, C. S.; Kenny, R. J.; Kelly, G. W.; Casiano, M. J.; Hulka, J. R.; Richardson, B. R.

2016-01-01

As part of the Combustion Stability Tool Development project funded by the Air Force Space and Missile Systems Center, the NASA Marshall Space Flight Center was contracted to assemble and hot-fire test a multi-element integrated test article demonstrating combustion characteristics of an oxygen/hydrocarbon propellant oxidizer-rich staged-combustion engine thrust chamber. Such a test article simulates flow through the main injectors of oxygen/kerosene oxidizer-rich staged combustion engines such as the Russian RD-180 or NK-33 engines, or future U.S.-built engine systems such as the Aerojet-Rocketdyne AR-1 engine or the Hydrocarbon Boost program demonstration engine. On the current project, several configurations of new main injectors were considered for the thrust chamber assembly of the integrated test article. All the injector elements were of the gas-centered swirl coaxial type, similar to those used on the Russian oxidizer-rich staged-combustion rocket engines. In such elements, oxidizer-rich combustion products from the preburner/turbine exhaust flow through a straight tube, and fuel exiting from the combustion chamber and nozzle regenerative cooling circuits is injected near the exit of the oxidizer tube through tangentially oriented orifices that impart a swirl motion such that the fuel flows along the wall of the oxidizer tube in a thin film. In some elements there is an orifice at the inlet to the oxidizer tube, and in some elements there is a sleeve or "shield" inside the oxidizer tube where the fuel enters. In the current project, several variations of element geometries were created, including element size (i.e., number of elements or pattern density), the distance from the exit of the sleeve to the injector face, the width of the gap between the oxidizer tube inner wall and the outer wall of the sleeve, and excluding the sleeve entirely. This paper discusses the design rationale for each of these element variations, including hydraulic, structural, thermal, combustion performance, and combustion stability considerations. This paper also discusses the fabrication and assembly of the injector components, including the injector body/interpropellant plate, the additive manufactured GRCop-84 faceplate, and the pieces that make up the injector elements including the oxidizer tube, an inlet to the oxidizer tube, and a facenut that includes the fuel tangential inlets and forms the initial recessed volume where oxidizer and fuel first interact. Hot-fire test results of these main injector designs in an integrated test article that includes an oxidizer-rich preburner are described in companion papers at this JANNAF meeting.

The Shared Superintendency: The Iowa Experience.

ERIC Educational Resources Information Center

Decker, Robert H.; Talbot, Adrian P.

1990-01-01

Based on interviews with almost the entire population of shared superintendents in Iowa, this article discusses the pros and cons of shared superintendencies. Problems arose concerning logistics, decreased administrator visibility, loss of personal control, keeping district policies separate, and favoritism charges. Participants experienced high…

Toward a nuclear-weapon-free world: a Chinese perspective

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, D.

In the present article, the author addresses China's policy on proliferation and nuclear testing. China, after observing an unannounced moratorium for more than a year, conducted a test last October, and maintains that it cannot exclude the need to carry out a few more tests for a certain period of time for national defense. The author discusses reasons for future tests. He suggests that a major factor in the testing may be to improve the safety and reliability of the present Chinese arsenal. He believes that whether or not China continues to test nuclear weapons will depend upon the balancemore » of different national interests as perceived by the Chinese government. Following the underground test in Xinjiang province last October, the Chinese government issued a letter to U.N. Secretary-General Boutros Boutros-Ghali saying that it was entirely for the purpose of self-defense that China developed and possessed a small number of nuclear weapons, and that it had always exercised utmost restraint on nuclear testing. The letter also states that [open quotes]after a comprehensive test ban treaty is concluded and comes into effect, China will abide by it and carry out no more nuclear tests.[close quotes] The author concludes that an international treaty banning nuclear weapons tests is important, but a no-first-use agreement would be just as useful. He discusses options for effecting a world-wide non-proliferation policy.« less

Concrete Masonry Designs: Educational Issue.

ERIC Educational Resources Information Center

Hertzberg, Randi, Ed.

2001-01-01

This special journal issue addresses concrete masonry in educational facilities construction. The issue's feature articles are: (1) "It Takes a Village To Construct a Massachusetts Middle School," describing a middle school constructed almost entirely of concrete masonry and modeled after a typical small New England village; (2)…

Research Out of the Shadows: A Reply to Rist.

ERIC Educational Resources Information Center

Barone, Thomas E.

1987-01-01

Replies to Rist's unfavorable evaluation of Barone's own article critiquing the arts program of a black elementary school. Argues that quantitative social science research has unsuccessfully modeled itself on scientific methodology, but camouflages its subjectivity and fictionalizes the entire research undertaking. Crafting an educational…

The Early Years: Discovering through Deconstruction

ERIC Educational Resources Information Center

Ashbrook, Peggy

2016-01-01

Taking objects apart including old electronics, product packing, and living plants, helps children understand how things work. Documenting this "unbuilding" or "deconstructing" encourages children to first consider the entire object, then the parts, and finally, the purpose of the parts. This article provides a lesson based on…

Meaningful and Purposeful Practice

ERIC Educational Resources Information Center

Clementi, Donna

2014-01-01

This article describes a graphic, designed by Clementi and Terrill, the authors of "Keys to Planning for Learning" (2013), visually representing the components that contribute to meaningful and purposeful practice in learning a world language, practice that leads to greater proficiency. The entire graphic is centered around the letter…

Innovative Advances in Connectivity and Community Pharmacist Patient Care Services: Implications for Patient Safety.

PubMed

Bacci, Jennifer L; Berenbrok, Lucas A

2018-06-07

The scope of community pharmacy practice has expanded beyond the provision of drug product to include the provision of patient care services. Likewise, the community pharmacist's approach to patient safety must also expand beyond prevention of errors during medication dispensing to include optimization of medications and prevention of adverse events throughout the entire medication use process. Connectivity to patient data and other healthcare providers has been a longstanding challenge in community pharmacy with implications for the delivery and safety of patient care. Here, we describe three innovative advances in connectivity in community pharmacy practice that enhance patient safety in the provision of community pharmacist patient care services across the entire medication use process. Specifically, we discuss the growing use of immunization information systems, quality improvement platforms, and health information exchanges in community pharmacy practice and their implications for patient safety. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

The effect of the illness episode approach on Medicare beneficiaries' health insurance decisions.

PubMed Central

Sofaer, S; Kenney, E; Davidson, B

1992-01-01

This article reports on a quasi-experimental test of the Illness Episode Approach (IEA), a new approach to providing Medicare beneficiaries with information about the financial consequences of alternative health care coverage decisions. Beneficiaries were randomly assigned to free, three-hour workshops, half using materials developed through application of the IEA, half using traditional comparative information on insurance options. Analysis of data collected before and after the workshops indicates that participants in the Illness Episode sessions were more likely to drop duplicative coverage, to spend less on premiums, and to report that their decisions to change coverage had met their expectations. The entire sample of workshop participants showed significant increases in knowledge of Medicare and their own insurance, as well as improved satisfaction with the cost of their health care coverage. PMID:1464539

Main Pipelines Corrosion Monitoring Device

NASA Astrophysics Data System (ADS)

Anatoliy, Bazhenov; Galina, Bondareva; Natalia, Grivennaya; Sergey, Malygin; Mikhail, Goryainov

2017-01-01

The aim of the article is to substantiate the technical solution for the problem of monitoring corrosion changes in oil and gas pipelines with use (using) of an electromagnetic NDT method. Pipeline wall thinning under operating conditions can lead to perforations and leakage of the product to be transported outside the pipeline. In most cases there is danger for human life and environment. Monitoring of corrosion changes in pipeline inner wall under operating conditions is complicated because pipelines are mainly made of structural steels with conductive and magnetic properties that complicate test signal passage through the entire thickness of the object under study. The technical solution of this problem lies in monitoring of the internal corrosion changes in pipes under operating conditions in order to increase safety of pipelines by automated prediction of achieving the threshold pre-crash values due to corrosion.

Art of reading a journal article: Methodically and effectively

PubMed Central

Subramanyam, RV

2013-01-01

Background: Reading scientific literature is mandatory for researchers and clinicians. With an overflow of medical and dental journals, it is essential to develop a method to choose and read the right articles. Objective: To outline a logical and orderly approach to reading a scientific manuscript. By breaking down the task into smaller, step-by-step components, one should be able to attain the skills to read a scientific article with ease. Methods: The reader should begin by reading the title, abstract and conclusions first. If a decision is made to read the entire article, the key elements of the article can be perused in a systematic manner effectively and efficiently. A cogent and organized method is presented to read articles published in scientific journals. Conclusion: One can read and appreciate a scientific manuscript if a systematic approach is followed in a simple and logical manner. PMID:23798833

Method and apparatus for producing a carbon based foam article having a desired thermal-conductivity gradient

DOEpatents

Klett, James W [Knoxville, TN; Cameron, Christopher Stan [Sanford, NC

2010-03-02

A carbon based foam article is made by heating the surface of a carbon foam block to a temperature above its graphitizing temperature, which is the temperature sufficient to graphitize the carbon foam. In one embodiment, the surface is heated with infrared pulses until heat is transferred from the surface into the core of the foam article such that the graphitizing temperature penetrates into the core to a desired depth below the surface. The graphitizing temperature is maintained for a time sufficient to substantially entirely graphitize the portion of the foam article from the surface to the desired depth below the surface. Thus, the foam article is an integral monolithic material that has a desired conductivity gradient with a relatively high thermal conductivity in the portion of the core that was graphitized and a relatively low thermal conductivity in the remaining portion of the foam article.

Social capital, economics, and health: new evidence.

PubMed

Scheffler, Richard M; Brown, Timothy T

2008-10-01

In introducing this Special Issue on Social Capital and Health, this article tracks the popularization of the term and sheds light on the controversy surrounding the term and its definitions. It sets out four mechanisms that link social capital with health: making information available to community members, impacting social norms, enhancing the health care services and their accessibility in a community, and offering psychosocial support networks. Approaches to the measurement of social capital include the Social Capital Community Benchmark Survey (SCCBS) developed by Robert Putnam, and the Petris Social Capital Index (PSCI), which looks at community voluntary organizations using public data available for the entire United States. The article defines community social capital (CSC) as the extent and density of trust, cooperation, and associational links and activity within a given population. Four articles on CSC are introduced in two categories: those that address behaviors -- particularly utilization of health services and use of tobacco, alcohol, and drugs; and those that look at links between social capital and physical or mental health. Policy implications include: funding and/or tax subsidies that would support the creation of social capital; laws and regulations; and generation of enthusiasm among communities and leaders to develop social capital. The next steps in the research programme are to continue testing the mechanisms; to look for natural experiments; and to find better public policies to foster social capital.

Large-scale automated analysis of news media: a novel computational method for obesity policy research.

PubMed

Hamad, Rita; Pomeranz, Jennifer L; Siddiqi, Arjumand; Basu, Sanjay

2015-02-01

Analyzing news media allows obesity policy researchers to understand popular conceptions about obesity, which is important for targeting health education and policies. A persistent dilemma is that investigators have to read and manually classify thousands of individual news articles to identify how obesity and obesity-related policy proposals may be described to the public in the media. A machine learning method called "automated content analysis" that permits researchers to train computers to "read" and classify massive volumes of documents was demonstrated. 14,302 newspaper articles that mentioned the word "obesity" during 2011-2012 were identified. Four states that vary in obesity prevalence and policy (Alabama, California, New Jersey, and North Carolina) were examined. The reliability of an automated program to categorize the media's framing of obesity as an individual-level problem (e.g., diet) and/or an environmental-level problem (e.g., obesogenic environment) was tested. The automated program performed similarly to human coders. The proportion of articles with individual-level framing (27.7-31.0%) was higher than the proportion with neutral (18.0-22.1%) or environmental-level framing (16.0-16.4%) across all states and over the entire study period (P<0.05). A novel approach to the study of how obesity concepts are communicated and propagated in news media was demonstrated. © 2014 The Obesity Society.

Large-Scale Automated Analysis of News Media: A Novel Computational Method for Obesity Policy Research

PubMed Central

Hamad, Rita; Pomeranz, Jennifer L.; Siddiqi, Arjumand; Basu, Sanjay

2015-01-01

Objective Analyzing news media allows obesity policy researchers to understand popular conceptions about obesity, which is important for targeting health education and policies. A persistent dilemma is that investigators have to read and manually classify thousands of individual news articles to identify how obesity and obesity-related policy proposals may be described to the public in the media. We demonstrate a novel method called “automated content analysis” that permits researchers to train computers to “read” and classify massive volumes of documents. Methods We identified 14,302 newspaper articles that mentioned the word “obesity” during 2011–2012. We examined four states that vary in obesity prevalence and policy (Alabama, California, New Jersey, and North Carolina). We tested the reliability of an automated program to categorize the media’s “framing” of obesity as an individual-level problem (e.g., diet) and/or an environmental-level problem (e.g., obesogenic environment). Results The automated program performed similarly to human coders. The proportion of articles with individual-level framing (27.7–31.0%) was higher than the proportion with neutral (18.0–22.1%) or environmental-level framing (16.0–16.4%) across all states and over the entire study period (p<0.05). Conclusion We demonstrate a novel approach to the study of how obesity concepts are communicated and propagated in news media. PMID:25522013

DACS II - A distributed thermal/mechanical loads data acquisition and control system

NASA Technical Reports Server (NTRS)

Zamanzadeh, Behzad; Trover, William F.; Anderson, Karl F.

1987-01-01

A distributed data acquisition and control system has been developed for the NASA Flight Loads Research Facility. The DACS II system is composed of seven computer systems and four array processors configured as a main computer system, three satellite computer systems, and 13 analog input/output systems interconnected through three independent data networks. Up to three independent heating and loading tests can be run concurrently on different test articles or the entire system can be used on a single large test such as a full scale hypersonic aircraft. Thermal tests can include up to 512 independent adaptive closed loop control channels. The control system can apply up to 20 MW of heating to a test specimen while simultaneously applying independent mechanical loads. Each thermal control loop is capable of heating a structure at rates of up to 150 F per second over a temperature range of -300 to +2500 F. Up to 64 independent mechanical load profiles can be commanded along with thermal control. Up to 1280 analog inputs monitor temperature, load, displacement and strain on the test specimens with real time data displayed on up to 15 terminals as color plots and tabular data displays. System setup and operation is accomplished with interactive menu-driver displays with extensive facilities to assist the users in all phases of system operation.

Development of Bonded Joint Technology for a Rigidizable-Inflatable Deployable Truss

NASA Technical Reports Server (NTRS)

Smeltzer, Stanley S., III

2006-01-01

Microwave and Synthetic Aperture Radar antenna systems have been developed as instrument systems using truss structures as their primary support and deployment mechanism for over a decade. NASA Langley Research Center has been investigating fabrication, modular assembly, and deployment methods of lightweight rigidizable/inflatable linear truss structures during that time for large spacecraft systems. The primary goal of the research at Langley Research Center is to advance these existing state-of-the-art joining and deployment concepts to achieve prototype system performance in a relevant space environment. During 2005, the development, fabrication, and testing of a 6.7 meter multi-bay, deployable linear truss was conducted at Langley Research Center to demonstrate functional and precision metrics of a rigidizable/inflatable truss structure. The present paper is intended to summarize aspects of bonded joint technology developed for the 6.7 meter deployable linear truss structure while providing a brief overview of the entire truss fabrication, assembly, and deployment methodology. A description of the basic joint design, surface preparation investigations, and experimental joint testing of component joint test articles will be described. Specifically, the performance of two room temperature adhesives were investigated to obtain qualitative data related to tube folding testing and quantitative data related to tensile shear strength testing. It was determined from the testing that a polyurethane-based adhesive best met the rigidizable/inflatable truss project requirements.

Advanced Mathematical Thinking

ERIC Educational Resources Information Center

Dubinsky, Ed; McDonald, Michael A.; Edwards, Barbara S.

2005-01-01

In this article we propose the following definition for advanced mathematical thinking: Thinking that requires deductive and rigorous reasoning about mathematical notions that are not entirely accessible to us through our five senses. We argue that this definition is not necessarily tied to a particular kind of educational experience; nor is it…

A Classroom Market for Extra Credit: A Semester-Long Experiment

ERIC Educational Resources Information Center

Staveley-O'Carroll, James

2016-01-01

This article describes an innovative pedagogical technique, applicable to most economics courses, that offers students a deeper understanding of market equilibrium, inflation, real and nominal interest rates, intertemporal choice, and financial markets. Students earn extra credit, pooled together for the entire class, by correctly answering…

Welcome, Mr. Director, and Good Luck!

ERIC Educational Resources Information Center

Rosa, Rafael

2009-01-01

Museum education leaders often find themselves thrust into greater responsibility without an opportunity to prepare themselves for the challenges ahead. In this article, I discuss my own struggles transitioning from manager of a specific program area to oversight of an entire education department. This transition happened unexpectedly, and the…

Management on the Go

ERIC Educational Resources Information Center

Technology & Learning, 2005

2005-01-01

The employment of administrative tools for effective management is evaluated in this article. Using an administrative tool like a Palm[R] handheld computer and appropriate software can make the difference. For anyone running a single school or an entire district, managing data is the key to maintaining an efficient organization. Many…

Electrophoretic mobility shift in native gels indicates calcium-dependent structural changes of neuronal calcium sensor proteins.

PubMed

Viviano, Jeffrey; Krishnan, Anuradha; Wu, Hao; Venkataraman, Venkat

2016-02-01

In proteins of the neuronal calcium sensor (NCS) family, changes in structure as well as function are brought about by the binding of calcium. In this article, we demonstrate that these structural changes, solely due to calcium binding, can be assessed through electrophoresis in native gels. The results demonstrate that the NCS proteins undergo ligand-dependent conformational changes that are detectable in native gels as a gradual decrease in mobility with increasing calcium but not other tested divalent cations such as magnesium, strontium, and barium. Surprisingly, such a gradual change over the entire tested range is exhibited only by the NCS proteins but not by other tested calcium-binding proteins such as calmodulin and S100B, indicating that the change in mobility may be linked to a unique NCS family feature--the calcium-myristoyl switch. Even within the NCS family, the changes in mobility are characteristic of the protein, indicating that the technique is sensitive to the individual features of the protein. Thus, electrophoretic mobility on native gels provides a simple and elegant method to investigate calcium (small ligand)-induced structural changes at least in the superfamily of NCS proteins. Copyright © 2015 Elsevier Inc. All rights reserved.

Integrated Testing Approaches for the NASA Ares I Crew Launch Vehicle

NASA Technical Reports Server (NTRS)

Taylor, James L.; Cockrell, Charles E.; Tuma, Margaret L.; Askins, Bruce R.; Bland, Jeff D.; Davis, Stephan R.; Patterson, Alan F.; Taylor, Terry L.; Robinson, Kimberly L.

2008-01-01

The Ares I crew launch vehicle is being developed by the U.S. National Aeronautics and Space Administration (NASA) to provide crew and cargo access to the International Space Station (ISS) and, together with the Ares V cargo launch vehicle, serves as a critical component of NASA's future human exploration of the Moon. During the preliminary design phase, NASA defined and began implementing plans for integrated ground and flight testing necessary to achieve the first human launch of Ares I. The individual Ares I flight hardware elements - including the first stage five segment booster (FSB), upper stage, and J-2X upper stage engine - will undergo extensive development, qualification, and certification testing prior to flight. Key integrated system tests include the upper stage Main Propulsion Test Article (MPTA), acceptance tests of the integrated upper stage and upper stage engine assembly, a full-scale integrated vehicle ground vibration test (IVGVT), aerodynamic testing to characterize vehicle performance, and integrated testing of the avionics and software components. The Ares I-X development flight test will provide flight data to validate engineering models for aerodynamic performance, stage separation, structural dynamic performance, and control system functionality. The Ares I-Y flight test will validate ascent performance of the first stage, stage separation functionality, validate the ability of the upper stage to manage cryogenic propellants to achieve upper stage engine start conditions, and a high-altitude demonstration of the launch abort system (LAS) following stage separation. The Orion 1 flight test will be conducted as a full, un-crewed, operational flight test through the entire ascent flight profile prior to the first crewed launch.

Integrated System Test Approaches for the NASA Ares I Crew Launch Vehicle

NASA Technical Reports Server (NTRS)

Cockrell, Charles E., Jr.; Askins, Bruce R.; Bland, Jeffrey; Davis, Stephan; Holladay, Jon B.; Taylor, James L.; Taylor, Terry L.; Robinson, Kimberly F.; Roberts, Ryan E.; Tuma, Margaret

2007-01-01

The Ares I Crew Launch Vehicle (CLV) is being developed by the U.S. National Aeronautics and Space Administration (NASA) to provide crew access to the International Space Station (ISS) and, together with the Ares V Cargo Launch Vehicle (CaLV), serves as one component of a future launch capability for human exploration of the Moon. During the system requirements definition process and early design cycles, NASA defined and began implementing plans for integrated ground and flight testing necessary to achieve the first human launch of Ares I. The individual Ares I flight hardware elements: the first stage five segment booster (FSB), upper stage, and J-2X upper stage engine, will undergo extensive development, qualification, and certification testing prior to flight. Key integrated system tests include the Main Propulsion Test Article (MPTA), acceptance tests of the integrated upper stage and upper stage engine assembly, a full-scale integrated vehicle dynamic test (IVDT), aerodynamic testing to characterize vehicle performance, and integrated testing of the avionics and software components. The Ares I-X development flight test will provide flight data to validate engineering models for aerodynamic performance, stage separation, structural dynamic performance, and control system functionality. The Ares I-Y flight test will validate ascent performance of the first stage, stage separation functionality, and a highaltitude actuation of the launch abort system (LAS) following separation. The Orion-1 flight test will be conducted as a full, un-crewed, operational flight test through the entire ascent flight profile prior to the first crewed launch.

Testing and Analysis of a Composite Non-Cylindrical Aircraft Fuselage Structure. Part 1; Ultimate Design Loads

NASA Technical Reports Server (NTRS)

Przekop, Adam; Jegley, Dawn C.; Lovejoy, Andrew E.; Rouse, Marshall; Wu, Hsi-Yung T.

2016-01-01

The Environmentally Responsible Aviation Project aimed to develop aircraft technologies enabling significant fuel burn and community noise reductions. Small incremental changes to the conventional metallic alloy-based 'tube and wing' configuration were not sufficient to achieve the desired metrics. One airframe concept identified by the project as having the potential to dramatically improve aircraft performance was a composite-based hybrid wing body configuration. Such a concept, however, presented inherent challenges stemming from, among other factors, the necessity to transfer wing loads through the entire center fuselage section which accommodates a pressurized cabin confined by flat or nearly flat panels. This paper discusses finite element analysis and testing of a large-scale hybrid wing body center section structure developed and constructed to demonstrate that the Pultruded Rod Stitched Efficient Unitized Structure concept can meet these challenging demands of the next generation airframes. Part I of the paper considers the five most critical load conditions, which are internal pressure only and positive and negative g-loads with and without internal pressure. Analysis results are compared with measurements acquired during testing. Performance of the test article is found to be closely aligned with predictions and, consequently, able to support the hybrid wing body design loads in pristine and barely visible impact damage conditions.

Flights of Fancy: Imaginary Travels as Motivation for Reading, Writing, and Speaking German.

ERIC Educational Resources Information Center

Bryant, Keri L.; Pohl, Rosa Marie

1994-01-01

The article describes an innovative teaching project suitable for students at any age and all levels of German. The project, conducted entirely in German, includes writing, reading, and speaking, and promotes the skills of letter-writing, reading for content, note-taking, and oral presentation. (JL)

Immersive Simulation in Constructivist-Based Classroom E-Learning

ERIC Educational Resources Information Center

McHaney, Roger; Reiter, Lauren; Reychav, Iris

2018-01-01

This article describes the development of a simulation-based online course combining sound pedagogy, educational technology, and real world expertise to provide university students with an immersive experience in storage management systems. The course developed in this example does more than use a simulation, the entire course is delivered using a…

Employers and the New Generation of Employees

ERIC Educational Resources Information Center

Smith, W. Stanton

2006-01-01

There are three generations that exist in the workplace today: baby boomers, Gen X, and Gen Y. Each generation shows an entire spectrum of human values, attitudes and beliefs. This article describes the characteristic attitudes and expectations of each generation. The author examines the differences that cause conflict and describes coping…

Web Development Simplified

ERIC Educational Resources Information Center

Becker, Bernd W.

2010-01-01

The author has discussed the Multimedia Educational Resource for Teaching and Online Learning site, MERLOT, in a recent Electronic Roundup column. In this article, he discusses an entirely new Web page development tool that MERLOT has added for its members. The new tool is called the MERLOT Content Builder and is directly integrated into the…

Vital Affordances, Occupying Niches: An Ecological Approach to Disability and Performance

ERIC Educational Resources Information Center

Dokumaci, Arseli

2017-01-01

This article proposes a new conceptual approach to disability and performance through a contribution that comes entirely from outside the disciplines; a re-theorisation of Gibson's [1979. "The Ecological Approach to Visual Perception". Hillsdale: Lawrence Erlbaum Associates] theory of affordances. Drawing on three visual ethnographies…

A Call for Faculty Reengagement in Governance

ERIC Educational Resources Information Center

Tinberg, Nalsey

2009-01-01

In this article, the author, as a faculty member drawn into administrative service over the past decade, describes how economic and fiscal challenges have steadily eroded, if not entirely eliminated, the crucial tenets of shared faculty and institutional governance. She sees this development as an academic form of the "shock doctrine" eloquently…

Cosmopolitanism and the De-Colonial Option

ERIC Educational Resources Information Center

Mignolo, Walter

2010-01-01

What are the differences between cosmopolitanism and globalization? Are they "natural" historical processes or are they designed for specific purposes? Was Kant cosmopolitanism good for the entire population of the globe or did it respond to a particular Eurocentered view of what a cosmo-polis should be? The article argues that, while…

Ear Pieces

ERIC Educational Resources Information Center

DiJulio, Betsy

2011-01-01

In this article, the author describes an art project wherein students make fanciful connections between art and medicine. This project challenges students to interpret "ear idioms" (e.g. "blow it out your ear," "in one ear and out the other") by relying almost entirely on realistic ear drawings, the placement of them, marks, and values. In that…

Developing Critical Thinking for the Internet

ERIC Educational Resources Information Center

Pachtman, Andrew B.

2012-01-01

The internet is the defining technology for an entire generation. It requires the student to be able to critically evaluate information. It also requires the student to think critically about what information is contained in the information retrieved. How do we prepare developmental education students for these tasks? This article discusses the…

Getting the Swing of Surface Gravity

ERIC Educational Resources Information Center

Thomas, Brian C.; Quick, Matthew

2012-01-01

Sports are a popular and effective way to illustrate physics principles. Baseball in particular presents a number of opportunities to motivate student interest and teach concepts. Several articles have appeared in this journal on this topic, illustrating a wide variety of areas of physics. In addition, several websites and an entire book are…

Dance Specialists around the World--A Living History

ERIC Educational Resources Information Center

Musmon, Margaret; Welsh, Kariamu; Heath, Freddie-Lee; Minton, Sandra; Laverty, Mary Ann; Maeshiba, Naoko; Weeks, Sandy; Cardinal, Marita K.; Howton, Amy; Tavacioglu, Leyla

2008-01-01

Dance embraces the entire globe. Universities offer world dance classes to expose students to various styles and educators travel to different countries to experience how dance is viewed, performed, and taught in different cultures. In this article nine dance educators share their experiences of teaching and observing dance abroad. These accounts…

What's on Your Plate? Thinking Proportionally

ERIC Educational Resources Information Center

Bush, Sarah B.; Karp, Karen S.; Popelka, Liz; Bennett, Victoria Miller

2012-01-01

How better to promote a healthy lifestyle than to get an entire middle school involved in analyzing dietary information? This article describes a series of activities that was part of an interdisciplinary schoolwide effort to discuss healthy food choices. Mathematics teachers chose to focus on students' dietary habits and, over several days,…

Part Two: Infantile Spasms--The New Consensus

ERIC Educational Resources Information Center

Pellock, John M.; O'Hara, Kathryn

2011-01-01

This article presents the conclusion made by the consensus group regarding infantile spasms. The consensus group concluded that "infantile spasms are a major form of severe epileptic encephalopathy of early childhood that results in neurodevelopmental regression and imposes a significant health burden." The entire group agrees that the best…

Everything.

ERIC Educational Resources Information Center

Lubar, David

2003-01-01

Presents a farewell article to Dr. Pamela Sissi Carroll as editor of this journal. Gives a comical review of the field by covering the entire history of young adult literature, past, present, and future, describing the important people and organizations in the field, and explaining everything he has learned as a writer of young adult novels.…

The EDUTECH Report, 2002-2003.

ERIC Educational Resources Information Center

Warger, Thomas, Ed.

2003-01-01

This document consists of 12 issues, an entire volume year, of "The EDUTECH Report." The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue contains two feature articles, a page of news briefs, and a question and answer column. Most issues also contain brief quotations on education…

Children with Special Needs Are VIPs at Sesame Place

ERIC Educational Resources Information Center

Feldscher, Sharla; Stein, Gail

2008-01-01

This article features Sesame Place, the nation's only theme park based entirely on the award-winning television program "Sesame Street" located near Philadelphia, Pennsylvania. Arranged through the Greater Philadelphia Chapter of Variety--The Children's Charity, Sesame Place has hosted over 200,000 guests associated with Variety and…

Prezi: A Different Way to Present

ERIC Educational Resources Information Center

Yee, Kevin; Hargis, Jace

2010-01-01

In this article, the author discusses Prezi and compares it to other forms of presentation software. Taking a completely different approach to the entire concept of software for presentations, Prezi stands alone as a unique and wholly viable competitor to PowerPoint. With a "Prezi", users display words, images, and videos without using…

A Personal Appraisal of the MIBiol Courses in Entomology and Plant Pathology at Wolverhampton Polytechnic, 1967-71

ERIC Educational Resources Information Center

Ayerst, G.; Gower, A. M.

1972-01-01

Article provides brief description of two microbiology courses at the college level which have multiple characteristics. Course I provides instruction based on papers in biology and in a special subject. Course II is devoted entirely to the special subject. (PS)

Ethnography in a Virtual World

ERIC Educational Resources Information Center

Shumar, Wesley; Madison, Nora

2013-01-01

This article situates the discussion of virtual ethnography within the larger political/economic changes of twenty-first century consumer capitalism and suggests that increasingly our entire social world is a virtual world and that there were very particular utopian and dystopian framings of virtual community growing out of that history. The…

Toward Population Impact from Home Visiting

ERIC Educational Resources Information Center

Dodge, Kenneth A.; Goodman, W. Benjamin; Murphy, Robert; O'Donnell, Karen J.; Sato, Jeannine M.

2013-01-01

Although some home visiting programs have proven effective with the families they serve, no program has yet demonstrated broader impact on an entire county or state population. This article describes the Durham Connects program, which aims to achieve broad county-level effects by coalescing community agencies to serve early-intervention goals…

Flip Turns with Students

ERIC Educational Resources Information Center

Queeney, Kate

2014-01-01

Kate Queeney, a professor of chemistry at Smith College, turned to a former student to receive one-on-one instruction in swimming. The student, who had been unsure and scared in chemistry class, seemed like an entirely different person when teaching the teacher. This article describes how the author learned that there is something undeniably…

State Geography Using NOAA Polar-Orbiting Satellites.

ERIC Educational Resources Information Center

Stadler, Stephen J.

1985-01-01

NOAA polar-orbiting satellites have the capability of providing views of entire states. This article describes the characteristics of data from these satellites, indicates their advantages and disadvantages, and shows how the satellite data can be used in a statewide representation of physical geography for students at the introductory level. (RM)

Biological Analogs for Language Contact Situations

ERIC Educational Resources Information Center

Seliger, Herbert W.

1977-01-01

This article proposes that language contact can be best understood if the entire range of such situations from second language learning to evolution of dialects and creoles is studied within a framework analogical to the symbiosis of living organisms. Language contact is viewed in terms of dynamic evolutionary stages. (CHK)

Using the Teaching Portfolio to Anticipate Programmatic Assessment

ERIC Educational Resources Information Center

Price, Kenneth R.

2013-01-01

Portfolios have long been a staple in professional writing courses: both in employment materials assignments and in entire classes that ask students to reflect on their experiential learning. Portfolios may also be used effectively in business communication teaching methods courses. This article details the justification and methodology for having…

Beyond Classroom Boundaries: Incorporating Context in Teaching.

ERIC Educational Resources Information Center

CATESOL Journal, 1994

1994-01-01

This English-as-a-Second-Language (ESL) journal periodically devotes entire issues to specific issues. The theme of this issue is "Incorporating Context in Teaching." Articles include: "Learning Beyond the Classroom: Developing the Community Connection" (Tim Beard); "Smiling through the Turbulence: The Flight Attendant Syndrome and Other Issues of…

Restorative Justice in Everyday Life: Beyond the Formal Ritual

ERIC Educational Resources Information Center

Wachtel, Ted

2003-01-01

Restorative justice provides a promising alternative to punitive models in justice and education. Most programs to date have focused on "conferencing," where victims and offenders are brought together for mediation and reconciliation. This article extends the restorative model to the entire milieu of an alternative school setting. (Contains 3…

Clinical application of entire gastrointestinal barium meal combined with multi-temporal abdominal films in patients with intestinal neuronal dysplasia type B.

PubMed

Li, Xiao-Yun; Li, Xiao-Gang; Du, Ming-Guo; Chen, Zhi-Dan; Tao, Zheng-Gui; Liao, Xiao-Feng

2013-01-01

To report and evaluate the application of entire gastrointestinal barium meal combined with multi-temporal abdominal films in the diagnosis of patients with intestinal neuronal dysplasia type B (IND type B). Thirty-six patients with symptoms of long-standing constipation were enrolled in this study. The study took place at the Department of General Surgery, Xiangyang Central Hospital, Hubei Province, China from July 2007 to October 2012. All of them had already been subjected to the tests of barium enema and anorectal manometry and were suspected to be IND type B, but were not confirmed by mucous membrane acetylcholinesterase determination. All underwent the entire gastrointestinal barium meal combined with multi-temporal abdominal films. The data was collected and then analyzed retrospectively. After entire gastrointestinal barium meal combined with multi-temporal abdominal films, 30 out of 36 cases in this group were diagnosed with intestinal neuronal diseases, and then were treated with appropriate surgical treatment. The postoperative pathological diagnosis was IND type B. The other 6 patients in this group still could not be diagnosed explicitly after the test; thus, we treated them with conservative treatment. Entire gastrointestinal barium meal combined with multi-temporal abdominal films has the advantage of being able to test the gastrointestinal transfer capabilities and to find physiological and pathological changes simultaneously. It could provide important proof for the diagnosis of patients with intestinal neuronal dysplasia type B.

Efficient Blockwise Permutation Tests Preserving Exchangeability

PubMed Central

Zhou, Chunxiao; Zwilling, Chris E.; Calhoun, Vince D.; Wang, Michelle Y.

2014-01-01

In this paper, we present a new blockwise permutation test approach based on the moments of the test statistic. The method is of importance to neuroimaging studies. In order to preserve the exchangeability condition required in permutation tests, we divide the entire set of data into certain exchangeability blocks. In addition, computationally efficient moments-based permutation tests are performed by approximating the permutation distribution of the test statistic with the Pearson distribution series. This involves the calculation of the first four moments of the permutation distribution within each block and then over the entire set of data. The accuracy and efficiency of the proposed method are demonstrated through simulated experiment on the magnetic resonance imaging (MRI) brain data, specifically the multi-site voxel-based morphometry analysis from structural MRI (sMRI). PMID:25289113

The EMIR experience in the use of software control simulators to speed up the time to telescope

NASA Astrophysics Data System (ADS)

Lopez Ramos, Pablo; López-Ruiz, J. C.; Moreno Arce, Heidy; Rosich, Josefina; Perez Menor, José Maria

2012-09-01

One of the main problems facing development teams working on instrument control systems consists on the need to access mechanisms which are not available until well into the integration phase. The need to work with real hardware creates additional problems like, among others: certain faults cannot be tested due to the possibility of hardware damage, taking the system to the limit may shorten its operational lifespan and the full system may not be available during some periods due to maintenance and/or testing of individual components. These problems can be treated with the use of simulators and by applying software/hardware standards. Since information on the construction and performance of electro-mechanical systems is available at relatively early stages of the project, simulators are developed in advance (before the existence of the mechanism) or, if conventions and standards have been correctly followed, a previously developed simulator might be used. This article describes our experience in building software simulators and the main advantages we have identified, which are: the control software can be developed even in the absence of real hardware, critical tests can be prepared using the simulated systems, test system behavior for hardware failure situations that represent a risk of the real system, and the speed up of in house integration of the entire instrument. The use of simulators allows us to reduce development, testing and integration time.

Hot, humid air decontamination of a C-130 aircraft contaminated with spores of two acrystalliferous Bacillus thuringiensis strains, surrogates for Bacillus anthracis.

PubMed

Buhr, T L; Young, A A; Bensman, M; Minter, Z A; Kennihan, N L; Johnson, C A; Bohmke, M D; Borgers-Klonkowski, E; Osborn, E B; Avila, S D; Theys, A M G; Jackson, P J

2016-04-01

To develop test methods and evaluate survival of Bacillus thuringiensis kurstaki cry(-) HD-1 and B. thuringiensis Al Hakam spores after exposure to hot, humid air inside of a C-130 aircraft. Bacillus thuringiensis spores were either pre-inoculated on 1 × 2 or 2 × 2 cm substrates or aerosolized inside the cargo hold of a C-130 and allowed to dry. Dirty, complex surfaces (10 × 10 cm) swabbed after spore dispersal showed a deposition of 8-10 log10 m(-2) through the entire cargo hold. After hot, humid air decontamination at 75-80°C, 70-90% relative humidity for 7 days, 87 of 98 test swabs covering 0·98 m(2) , showed complete spore inactivation. There was a total of 1·67 log10 live CFU detected in 11 of the test swabs. Spore inactivation in the 98 test swabs was measured at 7·06 log10 m(-2) . Laboratory test methods for hot, humid air decontamination were scaled for a large-scale aircraft field test. The C-130 field test demonstrated that hot, humid air can be successfully used to decontaminate an aircraft. Transition of a new technology from research and development to acquisition at a Technology Readiness Level 7 is unprecedented. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

Voltage controlled current source

DOEpatents

Casne, Gregory M.

1992-01-01

A seven decade, voltage controlled current source is described for use in testing intermediate range nuclear instruments that covers the entire test current range of from 10 picoamperes to 100 microamperes. High accuracy is obtained throughout the entire seven decades of output current with circuitry that includes a coordinated switching scheme responsive to the input signal from a hybrid computer to control the input voltage to an antilog amplifier, and to selectively connect a resistance to the antilog amplifier output to provide a continuous output current source as a function of a preset range of input voltage. An operator controlled switch provides current adjustment for operation in either a real-time simulation test mode or a time response test mode.

Augmenting SCA project management and automation framework

NASA Astrophysics Data System (ADS)

Iyapparaja, M.; Sharma, Bhanupriya

2017-11-01

In our daily life we need to keep the records of the things in order to manage it in more efficient and proper way. Our Company manufactures semiconductor chips and sale it to the buyer. Sometimes it manufactures the entire product and sometimes partially and sometimes it sales the intermediary product obtained during manufacturing, so for the better management of the entire process there is a need to keep the track record of all the entity involved in it. Materials and Methods: Therefore to overcome with the problem the need raised to develop the framework for the maintenance of the project and for the automation testing. Project management framework provides an architecture which supports in managing the project by marinating the records of entire requirements, the test cases that were created for testing each unit of the software, defect raised from the past years. So through this the quality of the project can be maintained. Results: Automation framework provides the architecture which supports the development and implementation of the automation test script for the software testing process. Conclusion: For implementing project management framework the product of HP that is Application Lifecycle management is used which provides central repository to maintain the project.

Rotational manipulation of single cells and organisms using acoustic waves

PubMed Central

Ahmed, Daniel; Ozcelik, Adem; Bojanala, Nagagireesh; Nama, Nitesh; Upadhyay, Awani; Chen, Yuchao; Hanna-Rose, Wendy; Huang, Tony Jun

2016-01-01

The precise rotational manipulation of single cells or organisms is invaluable to many applications in biology, chemistry, physics and medicine. In this article, we describe an acoustic-based, on-chip manipulation method that can rotate single microparticles, cells and organisms. To achieve this, we trapped microbubbles within predefined sidewall microcavities inside a microchannel. In an acoustic field, trapped microbubbles were driven into oscillatory motion generating steady microvortices which were utilized to precisely rotate colloids, cells and entire organisms (that is, C. elegans). We have tested the capabilities of our method by analysing reproductive system pathologies and nervous system morphology in C. elegans. Using our device, we revealed the underlying abnormal cell fusion causing defective vulval morphology in mutant worms. Our acoustofluidic rotational manipulation (ARM) technique is an easy-to-use, compact, and biocompatible method, permitting rotation regardless of optical, magnetic or electrical properties of the sample under investigation. PMID:27004764

Rotational manipulation of single cells and organisms using acoustic waves.

PubMed

Ahmed, Daniel; Ozcelik, Adem; Bojanala, Nagagireesh; Nama, Nitesh; Upadhyay, Awani; Chen, Yuchao; Hanna-Rose, Wendy; Huang, Tony Jun

2016-03-23

The precise rotational manipulation of single cells or organisms is invaluable to many applications in biology, chemistry, physics and medicine. In this article, we describe an acoustic-based, on-chip manipulation method that can rotate single microparticles, cells and organisms. To achieve this, we trapped microbubbles within predefined sidewall microcavities inside a microchannel. In an acoustic field, trapped microbubbles were driven into oscillatory motion generating steady microvortices which were utilized to precisely rotate colloids, cells and entire organisms (that is, C. elegans). We have tested the capabilities of our method by analysing reproductive system pathologies and nervous system morphology in C. elegans. Using our device, we revealed the underlying abnormal cell fusion causing defective vulval morphology in mutant worms. Our acoustofluidic rotational manipulation (ARM) technique is an easy-to-use, compact, and biocompatible method, permitting rotation regardless of optical, magnetic or electrical properties of the sample under investigation.

Parallel Continuous Flow: A Parallel Suffix Tree Construction Tool for Whole Genomes

PubMed Central

Farreras, Montse

2014-01-01

Abstract The construction of suffix trees for very long sequences is essential for many applications, and it plays a central role in the bioinformatic domain. With the advent of modern sequencing technologies, biological sequence databases have grown dramatically. Also the methodologies required to analyze these data have become more complex everyday, requiring fast queries to multiple genomes. In this article, we present parallel continuous flow (PCF), a parallel suffix tree construction method that is suitable for very long genomes. We tested our method for the suffix tree construction of the entire human genome, about 3GB. We showed that PCF can scale gracefully as the size of the input genome grows. Our method can work with an efficiency of 90% with 36 processors and 55% with 172 processors. We can index the human genome in 7 minutes using 172 processes. PMID:24597675

Developing product quality standards for wheelchairs used in less-resourced environments

PubMed Central

McCambridge, Matt; Reese, Norman; Schoendorfer, Don; Wunderlich, Eric; Rushman, Chris; Mahilo, Dave

2017-01-01

Background Premature failures of wheelchairs in less-resourced environments (LREs) may be because of shortcomings in product regulation and quality standards. The standards published by the International Organization for Standardization (ISO) specify wheelchair tests for durability, safety and performance, but their applicability to products used in the rugged conditions of LREs is unclear. Because of this, wheelchair-related guidelines published by the World Health Organization recommended developing more rigorous durability tests for wheelchairs. Objectives This study was performed to identify the additional tests needed for LREs. Methods First, a literature review of the development of ISO test standards, wheelchair standards testing studies and wheelchair evaluations in LREs was performed. Second, expert advice from members of the Standards Working Group of the International Society of Wheelchair Professionals (ISWP) was compiled and reviewed. Results A total of 35 articles were included in the literature review. Participation from LREs was not observed in the ISO standards development. As per wheelchair testing study evidence, wheelchair models delivered in LREs did not meet the minimum standards requirement. Multiple part failures and repairs were observed with reviewed field evaluation studies. ISWP experts noted that several testing factors responsible for premature failures with wheelchair parts are not included in the standards and accordingly provided advice for additional test development. Conclusion The study findings indicate the need to develop a wide range of tests, with specific tests for measuring corrosion resistance of the entire wheelchair, rolling resistance of castors and rear wheels, and durability of whole wheelchair and castor assemblies. PMID:28936410

A comprehensive strength testing protocol offers no clinical value in predicting risk of hamstring injury: a prospective cohort study of 413 professional football players.

PubMed

van Dyk, Nicol; Bahr, Roald; Burnett, Angus F; Whiteley, Rod; Bakken, Arnhild; Mosler, Andrea; Farooq, Abdulaziz; Witvrouw, Erik

2017-12-01

Hamstring injuries remain prevalent across a number of professional sports. In football, the incidence has even increased by 4% per year at the Champions League level over the last decade. The role of muscle strength or strength ratios and their association with risk of hamstring injury remain restricted by small sample sizes and inconclusive results. The purpose of this study is to identify risk factors for hamstring injury in professional football players in an adequately powered, prospective cohort study. Using both established (isokinetic) and novel (eccentric hamstring test device) measures of muscle strength, we aimed to investigate the relationship between these strength characteristics over the entire range of motion with risk of hamstring injury. All teams (n=18) eligible to compete in the premier football league in Qatar underwent a comprehensive strength assessment during their annual periodic health evaluation at Aspetar Orthopaedic and Sports Medicine Hospital in Doha, Qatar. Variables included isokinetic strength, Nordic hamstring exercise strength and dynamic hamstring: quadriceps ratios. Of the 413 players included (68.2% of all league players), 66 suffered a hamstring injury over the two seasons. Only isokinetic quadriceps concentric at 300°/s (adjusted for bodyweight) was associated with risk of hamstring injury when considered categorically. Age, body mass and playing position were also associated with risk of hamstring injury. None of the other 23 strength variables examined were found to be associated with hamstring injury. The clinical value of isolated strength testing is limited, and its use in musculoskeletal screening to predict future hamstring injury is unfounded. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Rethinking School Choice: Educational Options, Control, and Sovereignty in Indian Country

ERIC Educational Resources Information Center

Castagno, Angelina E.; Garcia, David R.; Blalock, Nicole

2016-01-01

Despite the plethora of schooling options in Indigenous communities, the public policy debate, research, and discourse on school choice is almost entirely absent a specific engagement with how school choice intersects issues relevant to American Indian youth and tribal nations. This article suggests that Indian Country is an important and unique…

Creating a Desired Future

ERIC Educational Resources Information Center

Jenkins-Scott, Jackie

2008-01-01

When the author became president of Wheelock College in Boston in 2004, she asked the trustees and the entire campus community to engage in an innovative strategic planning and visioning process. The goal was to achieve consensus on a strategic vision for the future of Wheelock College by the end of her first year. This article discusses how…

Teaching Calculus with Wolfram|Alpha

ERIC Educational Resources Information Center

Dimiceli, Vincent E.; Lang, Andrew S. I. D.; Locke, LeighAnne

2010-01-01

This article describes the benefits and drawbacks of using Wolfram|Alpha as the platform for teaching calculus concepts in the lab setting. It is a result of our experiences designing and creating an entirely new set of labs using Wolfram|Alpha. We present the reasoning behind our transition from using a standard computer algebra system (CAS) to…

The Circle of Courage: Restorative Approaches in South African Schools

ERIC Educational Resources Information Center

Coetzee, Charles

2005-01-01

An entirely different approach is needed regarding the way in which troubled learners are perceived and approached. The removal of traditional punitive methods has left many educators unequipped for youth showing destructive behavior. This article reviews the shift towards a restorative approach within education in the Western Cape, South Africa.…

Creating Safe Schools

ERIC Educational Resources Information Center

Bucher, Katherine T.; Manning, M. Lee

2005-01-01

Violent and potentially violent incidents in schools in the United States continue to make the headlines, with school-related violent deaths in the United States in the first half of the 2003-04 school year exceeding the deaths for the entire 2002-03 academic year (Vail 2004). In this article, the authors look at the ultimate form of classroom…

Evaluating the Performance of Online K-12 Schools

ERIC Educational Resources Information Center

Carpenter, Dick; Kafer, Krista; Reeser, Kelly; Shafer, Sheryl

2015-01-01

This article examines K-12 online student and school performance across an entire state (Colorado) in the United States through two comparisons. First, state assessment scores of students in online schools are compared to those in traditional brick and mortar schools. Second, the accountability scores of online schools are compared to those of…

The Financial Burden of Attending University in Georgia: Implications for Rural Students

ERIC Educational Resources Information Center

Chankseliani, Maia

2013-01-01

By evaluating the impact of policies to financially support university students in Georgia, this article demonstrates the systematic spatial disparities that exist in a context of formally equal competition. The author uses a mixed-methods design, combining quantitative evidence on the entire population of Georgian university applicants in…

Protective Factor Screening for Prevention Practice: Sensitivity and Specificity of the Dessa-Mini

ERIC Educational Resources Information Center

Shapiro, Valerie B.; Kim, B. K. Elizabeth; Robitaille, Jennifer L.; LeBuffe, Paul A.

2017-01-01

The Devereux Student Strengths Assessment Mini (DESSA-Mini; Naglieri, LeBuffe, & Shapiro, 2011/2014) was designed to overcome practical obstacles to universal prevention screening. This article seeks to determine whether an entirely strength-based, 8-item screening instrument achieves technical accuracy in routine practice. Data come from a…

A Gift for the Giver: Helping Miss Liberty.

ERIC Educational Resources Information Center

Wright, Corinne

1986-01-01

This article describes the activities of a secondary social studies teacher as she involved her class--and eventually the entire school--in activities to support the restoration of the Statue of Liberty and Ellis Island. The students raised over $1,000 by producing an ethnic foods cookbook, holding a raffle, and selling buttons. (JDH)

We Keep Moving on

ERIC Educational Resources Information Center

Weinthal, Jeffrey L.

2010-01-01

On October 1, 2003, the author embarked upon the most important quest of his entire life as he joined the ranks of the many Starr Commonwealth students. Montcalm School at Starr Commonwealth was just what he needed after the extreme emotional rollercoaster that haunted him for most of his life. In this article, the author maps his road to…

Inside Linden Lab

ERIC Educational Resources Information Center

Atkinson, Tom

2008-01-01

In this article, the author provides an overview of Second Life[trademark], or simply SL, which was developed at Linden Lab, a San Francisco-based corporation. SL is an online society within a threee-dimensional virtual world entirely built and owned by its residents, where they can explore, build, socialize and participate in their own economy.…

The Purpose, Structure and Limitations of the Electoral College

ERIC Educational Resources Information Center

Webster, Gerald R.

2016-01-01

The U.S. Constitution was drafted in Philadelphia from late May to mid-September 1787. The fifty-five delegates to the Constitutional Convention gathered to revise the Articles of Confederation but soon decided to write an entirely new document. These "Framers" were committed to forming a representative democracy, but their largely…

Reflections on Designing a MPA Service-Learning Component: Lessons Learned

ERIC Educational Resources Information Center

Roman, Alexandru V.

2015-01-01

This article provides the "lessons learned" from the experience of redesigning two sections (face-to-face and online) of a core master of public administration class as a service-learning course. The suggestions made here can be traced to the entire process of the project, from the "seed idea" through its conceptualization and…

Data-Driven Intervention: Correcting Mathematics Students' Misconceptions, Not Mistakes

ERIC Educational Resources Information Center

Holmes, Vicki-Lynn; Miedema, Chelsea; Nieuwkoop, Lindsay; Haugen, Nicholas

2013-01-01

In an age when reform is based on standards and instruction is based on research, this article gives practical advice for how mathematics teachers can analyze errors in student problems to create interventions that aid not only the individual's development, but the entire class's as well. By learning how to correct mathematics students'…

Rural Issues in Rehabilitation Service Delivery: A Goodwill Industries of America Study.

ERIC Educational Resources Information Center

Larsen, Carmen O.; Foley, Jeffrey C.

1992-01-01

This article uses survey data to describe some common elements among rural vocational rehabilitation programs and differentiate them from their urban counterparts. The survey of 173 Goodwill Industries centers brought 78 responses. Thirteen centers (17%) characterized themselves as entirely rural; 22 (28%) as nonrural, and 43 organizations said…

Dogs, Cats, and Kids: Integrating Yoga into Elementary Physical Education

ERIC Educational Resources Information Center

Toscano, Lisa; Clemente, Fran

2008-01-01

This article describes the benefits of integrating yoga into elementary physical education classes. Taught as warm-up exercises or as an entire class, yoga offers children of any age and physical ability the opportunity to experience success in physical activity. Children need to experience joy while participating in physical activity in order to…

JPRS Report, Near East & South Asia

DTIC Science & Technology

1990-06-21

of the association of the sexes, as some people are doing, is entirely infantile , above all today. This is really not the priority. Frankly, the...Cairo LIWA’ AL-ISLAM in Arabic 26 Apr 90 pp 48-49 [Article by Asma ’ al-Husayni al-Ghabashi: "Muslim People of Oromia Break the Ethiopian Blockade

Amazing Muses of Science: An Interdisciplinary Project Creates Awareness of Female Scientists

ERIC Educational Resources Information Center

Carson, Beverly

2016-01-01

This article describes an interdisciplinary project that created awareness of female scientists in a public Montessori classroom. Every spring, the author's sixth-grade students write an educational play in which the entire class participates. Following an underwhelming response to asking students who are their favorite female scientists, the…

Defense.gov - Special Report - Social Media

Science.gov Websites

social media space, the Marine Corps now leads the way in the era of emerging media. Story» Featured Articles Social Media Shapes Military The Defense Department and all of its components use Facebook and other social media tools to help promote their initiatives as the entire informational environment

The Campbell Collaboration: Providing Better Evidence for a Better World

ERIC Educational Resources Information Center

Littell, Julia H.; White, Howard

2018-01-01

In this article, we trace the development of the Campbell Collaboration and its renewed efforts to build a world library of accurate, synthesized evidence to inform policy and practice and improve human well-being worldwide. Campbell systematic reviews and related evidence synthesis products provide unbiased summaries of entire bodies of empirical…

The Regionalist: Jeff Trzeciak--Wayne State University, Detroit

ERIC Educational Resources Information Center

Library Journal, 2004

2004-01-01

This article is about Jeff Trzeciak, the tech hotshot at the Wayne State libraries. He oversees instructional technology for the entire campus community, library technology services (with over 1000 workstations and 30 servers), digital library services, and the help desk. It is clear he loves his work. His passion, though, is creating online…

Science 101: Why Are Hippos Unguligrades?

ERIC Educational Resources Information Center

Robertson, Bill

2014-01-01

In this article, Bill Robinson describes the three main classifications of gait for animals: (1) Plantigrade--animals that walk on their entire foot; (2) Digitigrade--animals that walk on their "toes"; and (3) Unguligrade--animals that walk on the tips of their toes or hooves. Robinson explains each gait in great detail, but leaves his…

A Change Process at German University--Innovation through Information and Communication Technologies?

ERIC Educational Resources Information Center

Zentel, Peter; Bett, Katja; Meister, Dorothee M.; Rinn, Ulrike; Wedekind, Joachim

2004-01-01

In this article, we describe the current situation of virtual universities in Germany and pursue the question of whether innovation processes taking place throughout the entire higher education landscape. Our study shows that the integration of ICT [information and communication technologies] not only changes the medial characteristics of the…

A Systematic Review of Dropout from Organized Sport among Children and Youth

ERIC Educational Resources Information Center

Crane, Jeff; Temple, Viviene

2015-01-01

Leisure constraints theory was used as a framework to systematically review factors associated with dropout of organized sport among children and adolescents. Keyword searches for the population, context and construct of interest (i.e. dropout) identified articles from the entire contents of the following databases: Academic Search Complete, ERIC,…

Gaga for Google in the Twenty-First Century Advanced Placement Language Classroom

ERIC Educational Resources Information Center

Adams, Devon Christopher

2008-01-01

The migration of online educational needs to tools like Google applications, coupled with the realization that today's twenty-first-century students are digital natives who have lived their entire lives exposed to current technology, forces educators to find ways to use technology to enhance traditional curriculum. In this article, the author…

Foreclosed: Two Million Homeless Students and Counting

ERIC Educational Resources Information Center

McKibben, Sarah

2009-01-01

This article reports that according to First Focus, a bipartisan advocacy organization for children and families, a predicted two million children will lose their homes over the next two years because of the foreclosure crisis. From an economy deep in recession, an entirely new population of homeless students has emerged. And with job losses at…

The EDUTECH Report, 1995-96.

ERIC Educational Resources Information Center

EDUTECH Report, 1996

1996-01-01

This document consists of 12 issues, an entire volume year, of the EDUTECH Report published between April 1995 and March 1996. The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue typically contains two feature articles, a page of news briefs, a preview of the upcoming issue, and a…

The EDUTECH Report, 2000-2001.

ERIC Educational Resources Information Center

Warger, Thomas, Ed.

2001-01-01

This document consists of 12 issues, an entire volume year, of the EDUTECH Report. The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue contains two feature articles, a page of news briefs, a preview of the upcoming issue, and a question and answer column. Most issues also contain brief…

The EDUTECH Report, 1998-1999.

ERIC Educational Resources Information Center

EDUTECH Report, 1999

1999-01-01

This document consists of 12 issues, an entire volume year, of the EDUTECH Report. The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue contains two feature articles, a page of news briefs, a preview of the upcoming issue, and a question and answer column. Most issues also contain brief…

The EDUTECH Report, 1996-97.

ERIC Educational Resources Information Center

EDUTECH Report, 1996

1996-01-01

This document consists of 12 issues, an entire volume year, of the EDUTECH Report published between April 1996 and March 1997. The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue typically contains two feature articles, a page of news briefs, a preview of the upcoming issue, and a…

The EDUTECH Report, 1999-2000.

ERIC Educational Resources Information Center

EDUTECH Report, 2000

2000-01-01

This document consists of the 12 issues, an entire volume year, of the 1999-2000 EDUTECH Report. The newsletter's purpose is to alert faculty and administrators to issues in educational technology. Each issue contains two or three articles, a page of news briefs, a preview of the upcoming issue, and a question and answer column. Most issues also…

Unethical Admissions: Academic Integrity in Question.

PubMed

Ansah, Richard Hannis; Aikhuele, Daniel O; Yao, Liu

2017-08-01

The increasing unethical practices of graduates' admissions have heightened concerns about the integrity of the academy. This article informs this important subject that affects the students, admission systems, and the entire scientific community, thus, representing an approach against scholarly black market activities including falsified documents and unethical practices by consultants and students' recruitment agencies.

Developing a Marketing Mind-Set: Training and Mentoring for County Extension Employees

ERIC Educational Resources Information Center

Sneed, Christopher T.; Elizer, Amy Hastings; Hastings, Shirley; Barry, Michael

2016-01-01

Marketing the county Extension program is a critical responsibility of the entire county staff. This article describes a unique peer-to-peer training and mentoring program developed to assist county Extension staff in improving marketing skills and successfully developing and implementing a county Extension marketing plan. Data demonstrating…

Science, Volume 184 Number 4134. Energy.

ERIC Educational Resources Information Center

Abelson, Philip H., Ed.

1974-01-01

This entire issue of the "Science" journal is devoted to the topic of energy and issues relating to the energy crisis. Its content was chosen to present material relevant to important public decisions of the next few years. Twenty-six articles cover a wide range of topics, including the impact of the energy crisis on people and…

Lectura y Vida: Revista Latinoamericana de Lectura. (Reading and Life: Latin American Reading Magazine). 1998.

ERIC Educational Resources Information Center

Lectura y Vida: Revista Latinoamericana de Lectura, 1998

1998-01-01

The four 1998 issues of the journal on literacy education, entirely in Spanish, include these articles: "The Inevitable Radical Weakness of Language: Some Reflections about Forming Readers and Citizens" (Daniel Goldin); "Relationships among Reading and Writing, Thematic Units, Learning Through Research...In Search of Effective…

Moving an In-Class Module Online: A Case Study for Chemistry

ERIC Educational Resources Information Center

Seery, Michael K.

2012-01-01

This article summarises the author's experiences in running a module "Computers for Chemistry" entirely online for the past four years. The module, previously taught in a face-to-face environment, was reconfigured for teaching in an online environment. The rationale for moving online along with the design, implementation and evaluation of the…

International Trends in the Public and Private Financing of Higher Education

ERIC Educational Resources Information Center

Sanyal, Bikas C.; Johnstone, D. Bruce

2011-01-01

Beginning by analyzing the major qualitative and quantitative changes in higher education around the world, this article examines international trends in their financial implications. It then demonstrates the state's inability to bear the entire rising financial burden, and explores the role of self-financing, and of the non-profit and for-profit…

Exposing the Glosses in Seligman and Fowler's (2011) Straw-Man Arguments

ERIC Educational Resources Information Center

Dyckman, John

2011-01-01

The author was disappointed to see an entire special issue of the "American Psychologist" (January 2011) devoted to military psychology, but he was especially concerned about the one-sided moral justifications presented by Seligman and Fowler (2011) in the final article of the issue. The author feels they misrepresented potential objections to…

Moral Functioning: Navigating the Messy Landscape of Values in Finnish Preschools

ERIC Educational Resources Information Center

Puroila, Anna-Maija; Haho, Annu

2017-01-01

This article employs a narrative approach to explore educators' moral functioning in Finnish preschools. Our study is theoretically inspired by notions drawn from feminist and sociocultural studies, according to which education is understood as an entirely moral phenomenon. Within a holistic framework, moral functioning is understood as a concept…

Soil Moisture Active and Passive (SMAP) White-Painted Expanded Polystyrene (EPS) Radome Survivability Test

NASA Technical Reports Server (NTRS)

Mikhaylov, Rebecca; Kwack, Eug; Stegman, Matthew; Dawson, Douglas; Hoffman, Pamela

2015-01-01

NASA's SMAP Mission launched in January 2015 into a 685 km near-polar, sun-synchronous orbit. The SMAP instrument architecture incorporates an L-band radar and radiometer which share a common feedhorn and mesh reflector. The instrument rotates about the nadir axis at approximately 15 rpm, thereby providing a conically scanning wide swath antenna beam that is capable of achieving global coverage within three days. The radiometer and its associated electronics have tight thermal stability requirements in order to meet the required surface emittance measurement precision from space. Maintaining the thermal stabilities is quite challenging because the radiometer is located on a spinning platform that can either be in full sunlight or eclipse, and thus exposed to a highly transient environment. Stability requirements were met by integrating a light-weight Expanded Polystyrene (EPS) radome into the design to prevent solar illumination of the feed horn interior. The radome was painted white since the thermo-optical properties of bare sunlit EPS degrade rapidly over the three-year mission. Milling of the EPS and solvent within the white paint created cavities on the EPS surface which may introduce localized hot spots possibly violating the EPS glass transition temperature of 96degC and leading to structural integrity concerns. A three-day thermal test was conducted in a vacuum chamber to verify survivability of the radome during a simulated non-spin fault condition at end of mission. A portable solar simulator illuminated the test article and the beam irradiance was kept nearly constant during the entire 50 hour test, except during the first hour which simulated the expected 79degC on-orbit surface temperature of the radome. The test article survived based on the established pass criteria for three separate metrics: dimensional, optical property, and color. If any hot spots exist locally, they did not cause any observable permanent deformation when compared to pre- and post-test images. The test results increase confidence that there is a high probability that the radome will survive the worst-case scenario of a no-spin fault condition at the end of mission.

A Passive Earth-Entry Capsule for Mars Sample Return

NASA Technical Reports Server (NTRS)

Mitcheltree, Robert A.; Kellas, Sotiris

1999-01-01

A combination of aerodynamic analysis and testing, aerothermodynamic analysis, structural analysis and testing, impact analysis and testing, thermal analysis, ground characterization tests, configuration packaging, and trajectory simulation are employed to determine the feasibility of an entirely passive Earth entry capsule for the Mars Sample Return mission. The design circumvents the potential failure modes of a parachute terminal descent system by replacing that system with passive energy absorbing material to cushion the Mars samples during ground impact. The suggested design utilizes a spherically blunted 45-degree half-angle cone forebody with an ablative heat shield. The primary structure is a hemispherical, composite sandwich enclosing carbon foam energy absorbing material. Though no demonstration test of the entire system is included, results of the tests and analysis presented indicate that the design is a viable option for the Mars Sample Return Mission.

[Teaching, research, and extension service: botanist Honório da Costa Monteiro Filho].

PubMed

Bovini, Massimo G; Peixoto, Ariane Luna

2012-12-01

The article revisits the work of Honório da Costa Monteiro Filho, highlighting his contribution to the study of economic botany and the taxonomy of Brazilian Malvaceae. Many of his seventy articles, are still cited. Yet little is known about his important role in educating agronomists involved with Brazilian flora and the creation of the Botanical Society of Brazil. These topics are discussed in the article, along with his work on a project to reform the teaching of agronomy in Brazil. The entire works of Monteiro Filho, archival documents, his correspondence with other scientists, and his observations on plant labels in herbaria were researched; interviews were also conducted with people with ties to him.

Test aspects of the JPL Viterbi decoder

NASA Technical Reports Server (NTRS)

Breuer, M. A.

1989-01-01

The generation of test vectors and design-for-test aspects of the Jet Propulsion Laboratory (JPL) Very Large Scale Integration (VLSI) Viterbi decoder chip is discussed. Each processor integrated circuit (IC) contains over 20,000 gates. To achieve a high degree of testability, a scan architecture is employed. The logic has been partitioned so that very few test vectors are required to test the entire chip. In addition, since several blocks of logic are replicated numerous times on this chip, test vectors need only be generated for each block, rather than for the entire circuit. These unique blocks of logic have been identified and test sets generated for them. The approach employed for testing was to use pseudo-exhaustive test vectors whenever feasible. That is, each cone of logid is tested exhaustively. Using this approach, no detailed logic design or fault model is required. All faults which modify the function of a block of combinational logic are detected, such as all irredundant single and multiple stuck-at faults.

Treatment Options for Male Breast Cancer

MedlinePlus

... entire lump of tissue. If cancer is found, tests are done to study the cancer cells. Decisions about the best treatment are based on the results of these tests. The tests give information about: How quickly the ...

Treatment Option Overview (Male Breast Cancer)

MedlinePlus

... entire lump of tissue. If cancer is found, tests are done to study the cancer cells. Decisions about the best treatment are based on the results of these tests. The tests give information about: How quickly the ...

Stages of Male Breast Cancer

MedlinePlus

... entire lump of tissue. If cancer is found, tests are done to study the cancer cells. Decisions about the best treatment are based on the results of these tests. The tests give information about: How quickly the ...

49 CFR 230.41 - Flexible staybolts with caps.

Code of Federal Regulations, 2012 CFR

2012-10-01

... staybolts that have telltale holes between 3/16 inch and 7/32 inch in diameter, and which extend the entire... or other suitable method, that the telltale holes are open their entire length. Any leakage from these telltale holes during the hydrostatic test indicates that the bolt is broken and must be replaced...

49 CFR 230.41 - Flexible staybolts with caps.

Code of Federal Regulations, 2013 CFR

2013-10-01

... staybolts that have telltale holes between 3/16 inch and 7/32 inch in diameter, and which extend the entire... or other suitable method, that the telltale holes are open their entire length. Any leakage from these telltale holes during the hydrostatic test indicates that the bolt is broken and must be replaced...

49 CFR 230.41 - Flexible staybolts with caps.

Code of Federal Regulations, 2011 CFR

2011-10-01

... staybolts that have telltale holes between 3/16 inch and 7/32 inch in diameter, and which extend the entire... or other suitable method, that the telltale holes are open their entire length. Any leakage from these telltale holes during the hydrostatic test indicates that the bolt is broken and must be replaced...

49 CFR 230.41 - Flexible staybolts with caps.

Code of Federal Regulations, 2014 CFR

2014-10-01

... staybolts that have telltale holes between 3/16 inch and 7/32 inch in diameter, and which extend the entire... or other suitable method, that the telltale holes are open their entire length. Any leakage from these telltale holes during the hydrostatic test indicates that the bolt is broken and must be replaced...

2009 AERA Distinguished Lecture: Causes and Consequences of Cognitive Functioning across the Life Course

ERIC Educational Resources Information Center

Hauser, Robert M.

2010-01-01

Research on variation in cognitive abilities has focused largely on their genetic or experiential sources and on their economic consequences. This article takes a broader look at the consequences of cognitive ability--IQ--across the life course. Contrary to received wisdom, the effects of IQ on economic success are almost entirely mediated by…

Investigating Student Attitudes toward a Synchronous, Online Graduate Course in a Multi-User Virtual Learning Environment

ERIC Educational Resources Information Center

Annetta, Leonard; Murray, Marshall; Gull Laird, Shelby; Bohr, Stephanie; Park, John

2008-01-01

This article describes a graduate distance education course at North Carolina State University, which combined science content and pedagogy with video game design. The course was conducted entirely in a synchronous, online, Virtual Learning Environment (VLE) through the ActiveWorlds[TM] platform. Inservice teachers enrolled as graduate students in…

Some Upstarts in NCAA Tournament Are Unconventional Advertisers as Well

ERIC Educational Resources Information Center

Blumenstyk, Goldie

2008-01-01

This article reports how some colleges in the National Collegiate Athletic Association (NCAA) men's basketball tournament have produced unlikely commercials. One of them is Drake University, which has a TV ad that consists entirely of a series of numbers, words, phrases, and stylized drawings in two shades of blue instead of the usual pictures of…

Update: Applications of Research in Music Education Yearbook. Volume 24

ERIC Educational Resources Information Center

Rowman & Littlefield Education, 2006

2006-01-01

Readers of the online journal "Update: Applications of Research in Music Education" who prefer a printed copy of articles most relevant to their work will find them in the new 2005-2006 "Update Yearbook." Now available to everyone interested in the latest music education trends, the Yearbook contains in print the entire online issues for…

Imaging in the assessment and management of athletic pubalgia.

PubMed

Robinson, Philip; Bhat, Vineet; English, Bryan

2011-02-01

This article reviews the clinical, anatomical, and biomechanical basis of pubalgia and relates it to the potential imaging findings and subsequent management. Although the magnetic resonance imaging features typically seen in symptomatic athletes are emphasized, this condition remains a complex clinical problem, and treatment addressing the functional rehabilitation of the entire region is highlighted. © Thieme Medical Publishers.

Primary Supervision: Massachusetts General Hospital's child and adolescent psychiatry seminar

ERIC Educational Resources Information Center

Jellinek, Michael S.

2007-01-01

In this article, the author describes "Primary Supervision", a seminar he has led for approximately 20 years, which is designed for the entire class of nine first-year residents in Child and Adolescent Psychiatry training at Massachusetts General Hospital. The seminar meets for 1 hour each week throughout the first year. Through 900…

Behavioral Interventions to Address Sleep Disturbances in Children with Autism Spectrum Disorders: A Review

ERIC Educational Resources Information Center

Turner, Kylan S.; Johnson, Cynthia R.

2013-01-01

Sleep problems are a common occurrence among children with autism spectrum disorders (ASD). In addition to the adverse effects that sleep problems present for children's neurodevelopment, learning, and daytime behaviors, these sleep problems also present significant challenges for the entire family. This article outlines the results of a…

Multicultural Counseling Competencies Research: A 20-Year Content Analysis

ERIC Educational Resources Information Center

Worthington, Roger L.; Soth-McNett, Angela M.; Moreno, Matthew V.

2007-01-01

The authors conducted a 20-year content analysis of the entire field of empirical research on the multicultural counseling competencies (D. W. Sue et al., 1982). They conducted an exhaustive search for empirical research articles using PsycINFO, as well as complete reviews of the past 20 years of several journals (e.g., Journal of Counseling…

A Pioneer of Collegiate Women's Sports

ERIC Educational Resources Information Center

Lum, Lydia

2008-01-01

This article features North Carolina State University's Kay Yow, a pioneer of collegiate women's sports. An Olympic gold medal champion whose entire coaching career has been spent in her home state of North Carolina, Yow has amassed a remarkable lifetime win-loss record of 729-337. She is one of only six coaches to have won at least 700 career…

Singapore Pre-Service Secondary Mathematics Teachers' Content Knowledge: Findings from an International Comparative Study

ERIC Educational Resources Information Center

Toh, Tin Lam; Kaur, Berinderjeet; Koay, Phong Lee

2013-01-01

In this article, we explore the mathematical content knowledge of one entire cohort of pre-service teachers (N = 107) through analysing their performance in a Secondary Mathematics Audit that was developed for the International Comparative Studies in Mathematics Teacher Training that was initiated by the University of Plymouth. We study how their…

In-Service Training Programmes for Mathematics Teachers Nested in Transnational Policy Discourses

ERIC Educational Resources Information Center

Erixon, Eva-Lena; Wahlström, Ninni

2016-01-01

Results in mathematics on international knowledge surveys like Programme for International Student Assessment and Trends in International Mathematics and Science Study have become one of the most important factors for the perceived success or failure of schools and even entire education systems in the policy arena. In this article, we explore the…

The Struggle for the American Extracurriculum at Ithaca High School, 1890-1917

ERIC Educational Resources Information Center

Terzian, Sevan G.

2005-01-01

Numerous scholars have observed that the comprehensive high school has never succeeded in socially unifying the entire student body. This article attempts to explain why this has been the case by tracing the origins and development of the extracurriculum at Ithaca High School from 1890 to 1917. It demonstrates that students struggled with…

Library Services Online: Introducing Library Services for Online MBA Classes

ERIC Educational Resources Information Center

Slavin, Laura C.

2015-01-01

In this article, a librarian at Lincoln Memorial University creates library services for an MBA program offered entirely online that is in the early stages of development. The library services include a subject guide and 4 tutorials that will be added to the MBA online orientation. Other services include offering online office hours and…

Using Technology and Innovation for Planning Social and Economic Transformation in a Region of Mexico

ERIC Educational Resources Information Center

Villanueva, Gonzalo Rodriguez; Lagarda Leyva, Ernesto A.

2009-01-01

This article shows the possibility of achieving social transformation by applying the triple helix model, which establishes the university's participation and its research centers, the government and its three levels, and the private sector (Etzkowitz, 2002). These three allies have shared the vision and participated during the entire process,…

New Dimensions in Movement and Fitness through Integration

ERIC Educational Resources Information Center

Dean, Blair

2005-01-01

In this article, the author presents a number of ways to integrate academic content with physical activities. Among the activities are: (1) Paint the Alphabet, where students use different body parts (arms, legs, and head) as large paint brushes to paint the entire alphabet on an imaginary canvas; (2) Sequence Race, where students are placed into…

Constructivism and Reflectivism as the Logical Counterparts in TESOL: Learning Theory versus Teaching Methodology

ERIC Educational Resources Information Center

al Mahmud, Abdullah

2013-01-01

The gist of the entire constructivist learning theory is that learners are self-builders of their learning that occurs through a mental process in a social context or communication setting, and teachers as facilitators generate learning by creating the expected environment and/or utilizing the process. This article theoretically proves…

Lord Brouncker's Forgotten Sequence of Continued Fractions for Pi

ERIC Educational Resources Information Center

Osler, Thomas J.

2010-01-01

"Lord Brouncker's continued fraction for pi" is a well-known result. In this article, we show that Brouncker found not only this one continued fraction, but an entire infinite sequence of related continued fractions for pi. These were recorded in the "Arithmetica Infinitorum" by John Wallis, but appear to have been ignored and forgotten by modern…

Robert M. Finley Middle School: Building Community, Respect, and Achievement

ERIC Educational Resources Information Center

Principal Leadership, 2011

2011-01-01

This article features Robert M. Finley Middle School, a school that is considered by the entire Glen Cove, New York, community as important and successful. Gaps in student achievement have decreased significantly and all student achievement has improved over the last five years in this school, where nearly half of the 652 students are from…

Encapsulated Presentation: A New Paradigm of Blended Learning

ERIC Educational Resources Information Center

Rose, Richard; Ray, Jan

2011-01-01

This article is a presentation of a new mode of blended learning whose only goal is to enrich the quality of instruction in the face-to-face classroom through the simultaneous delivery of online and face-to-face components. Encapsulated presentation is the delivery of the entire presentation phase of a lesson in the classroom by electronic methods…

University of Arizona Scholar of Higher Education Will Lead Professors' Association

ERIC Educational Resources Information Center

Wilson, Robin

2008-01-01

This article reports that Gary Rhoades, who has spent his entire 22-year career at the University of Arizona studying issues that affect the professoriate, has been named general secretary of the American Association of University Professors (AAUP). Mr. Rhoades directs Arizona's Center for the Study of Higher Education. Leaders of the AAUP hope…

"Studies in Higher Education" 1976-2013: A Retrospective Using Citation Network Analysis

ERIC Educational Resources Information Center

Calma, Angelito; Davies, Martin

2015-01-01

This paper provides a citation network analysis of the publications in "Studies in Higher Education" from 1976 to 2013 inclusive. This represents the entire history of the journal to date. It analyses the most published authors, most cited authors and most discussed topics using keywords. 1056 articles were taken from Web of…

Marrying Two Existing Software Packages into an Efficient Online Tutoring Tool

ERIC Educational Resources Information Center

Byrne, Timothy

2007-01-01

Many teachers today use Learning Management Systems (LMS), several of which are open-source. Specific examples are Claroline and Moodle. However, they are not specifically designed for language learning, and hence not entirely suitable. In this article, I will compare two uses of the Claroline LMS available at Louvain-la-Neuve within the framework…

Open Arms, Open Hearts, Open Minds--Welcomed Once Again

ERIC Educational Resources Information Center

Hoffman, Ross

2003-01-01

The author's experiences as a non-Native student in a graduate program in Native studies are reflective of his experiences within Native communities. In this article, the author shares a story that speaks almost entirely about welcoming, acceptance, inclusion, and support. The author is a PhD candidate in the Department of Native Studies at Trent…

Trekking across the Science Boundaries

ERIC Educational Resources Information Center

Chaisson, Eric J.

2005-01-01

One of the more effective ways to convey the story of our origin and evolution is to present the entire chronicle in a multimedia format that allows today's tech-savvy students to browse at will, thereby extracting parts of the story at their own pace and comfort. This article describes an interactive CD-ROM (included in this issue of "The Science…

From Trash to Treasure--Rebuilding a '66 Vespa

ERIC Educational Resources Information Center

Boissonnault, Tom

2010-01-01

This article describes how the author got his 8th-grade students thinking about greener modes of transportation--and got them excited about technology education--in the course of rebuilding a badly damaged 1966 Vespa scooter. This turned out to be a wonderful project because it included almost the entire 8th grade, and showed students that…

Strapping Wings on a Caterpillar and Calling It a Butterfly: When Systemic Change Is Not Systemic

ERIC Educational Resources Information Center

Duffy, Francis M.

2008-01-01

This article challenges misperceptions about the definition of systemic change in school districts. While many contemporary change efforts are described as "systemic," in fact, they are not. The author also argues that a special instance of systemic change known as systemic transformational change is required to transform entire school…

Lectura y Vida: Revista Latinoamericana de Lectura (Reading and Life: Latin American Reading Magazine). 1996.

ERIC Educational Resources Information Center

Lectura y Vida: Revista Latinoamericana de Lectura, 1996

1996-01-01

The four 1996 issues of the journal, written entirely in Spanish and intended for reading teachers, include articles on these topics: design of the school and classroom environment for reading; a university experiment in cooperative learning and learning strategies; use of portfolios for evaluation of student work; evaluation of reading…

Lectura y Vida: Revista Latinoamericana de Lectura. (Reading and Life: Latin American Reading Magazine).

ERIC Educational Resources Information Center

Lectura y Vida: Revista Latinoamericana de Lectura, 1997

1997-01-01

The four issues of this journal, written entirely in Spanish, are intended for reading teachers. The first issue focuses on the role of school in the development of readers and writers and contains articles discussing the results of an investigation into the validity of the idea of "level" when measuring students' comprehension of…

Reforming the University Sector: Effects on Teaching Efficiency--Evidence from Italy

ERIC Educational Resources Information Center

Agasisti, Tommaso; Dal Bianco, Antonio

2009-01-01

In this article, we analyse the effects of teaching reforms in Italy. These were introduced in 1999, and changed the entire organization of university courses, where the Bachelor-Master (BA-MA) structure was adopted. The first step is to define the production process of higher education (HE). This process consists of several inputs (professors,…

Teaching Bioethics at Historically Black Colleges and Universities (HBCUs).

PubMed

Solberg, Lauren B; Freund Taylor, Carol

2015-05-01

This article describes a two-pronged, pilot bioethics education program implemented at a historically Black college/university to determine the interest in bioethics education and begin increasing the program's visibility. The pilot program included a Train-the-Trainer (TtT) component for selected faculty members and a simultaneously-running film- and-speaker series for the entire campus.

We All Belong! The Tecumseh Mural Project

ERIC Educational Resources Information Center

Lukawecky, Kristine

2009-01-01

The author of this article describes how as the visual-arts teacher of Tecumseh Public School, she brought the entire school and community together by creating a mural that promoted belonging. The mural involved tapping into the the creativity of all 400 students from kindergarten through eighth grade at Tecumseh while creating a work of art with…

Caution or Stasis: Using Research to Rethink Schools--Now

ERIC Educational Resources Information Center

Blodget, Alden

2016-01-01

In this article, Alden Blodget reflects on his more than 50 years of working in what he terms "the tragicomedy club of school reform," and suggests a need to rethink not just classroom teaching methods but the entire system. Blodget states that if the current system is built on faulty assumptions about learning, then there must be a…

Venturing into Scary Places: The Minority Experience

ERIC Educational Resources Information Center

Bennett, Craig

2007-01-01

Students who have lived as part of a majority for their entire life may find it frightening to be asked to visit a place where they will be in the minority. In this article, the author uses this assignment to demonstrate to his students how some people feel everyday. The Minority Experience assignment challenges students to actively participate in…

A Little Help from My Friends: Classroom 2.0 Educators Share Their Experiences

ERIC Educational Resources Information Center

Hargardon, Steve

2007-01-01

Blogs, wikis, podcasting, social networks... it seems the entire world has gone 2.0 crazy. Among the followers are educators, who, in ever increasing numbers, are integrating these online, interactive tools into their classrooms and even libraries. This article presents profiles of a few of educators who have taken the plunge, launching blogs,…

Reliability of psychophysiological responses across multiple motion sickness stimulation tests

NASA Technical Reports Server (NTRS)

Stout, C. S.; Toscano, W. B.; Cowings, P. S.

1995-01-01

Although there is general agreement that a high degree of variability exists between subjects in their autonomic nervous system responses to motion sickness stimulation, very little evidence exists that examines the reproducibility of autonomic responses within subjects during motion sickness stimulation. Our objectives were to examine the reliability of autonomic responses and symptom levels across five testing occasions using the (1) final minute of testing, (2) change in autonomic response and the change in symptom level, and (3) strength of the relationship between the change in symptom level and the change in autonomic responses across the entire motion sickness test. The results indicate that, based on the final minute of testing, the autonomic responses of heart rate, blood volume pulse, and respiration rate are moderately stable across multiple tests. Changes in heart rate, blood volume pulse, respiration rate, and symptoms throughout the test duration are less stable across the tests. Finally, autonomic responses and symptom levels are significantly related across the entire motion sickness test.

The Politics of Prevention: Lessons from the Neglected History of US HIV/AIDS Policy.

PubMed

Padamsee, Tasleem J

2017-02-01

The history of government action on HIV/AIDS has much to teach us about the dynamics and possibilities of US public health policy, but it has been insufficiently studied by social scientists of the epidemic. This article draws on a large set of original interviews with policy makers, thousands of news articles, and extensive documentation to reconstruct the history of three areas of debate and decision making about HIV prevention since 1990: needle exchange, HIV testing, and sex education for at-risk groups. These histories illuminate three key lessons. First, scientific evidence has less power to drive public health policy in the United States than in the United Kingdom, which is used as a comparison case to contextualize US choices within a broader range of options. Second, moral concerns weigh so heavily in the United States that a publicly articulated moral argument can countermand the dictates of solid scientific evidence, the voices of experts, and practical considerations to push public health policy in entirely oppositional directions. Third, having the ear of the presidential administration is usually a necessary-although not always sufficient-condition for the success of advocates trying to move US policy in the public health-indicated direction. Copyright © 2017 by Duke University Press.

Bromo-oxidation reaction in enzyme-entrapped alginate hollow microfibers

PubMed Central

Asthana, Amit; Lee, Kwang Ho; Shin, Su-Jung; Perumal, Jayakumar; Butler, Lauren; Lee, Sang-Hoon; Kim, Dong-Pyo

2011-01-01

In this article, the authors present the fabrication of an enzyme-entrapped alginate hollow fiber using a microfluidic device. Further use of enzyme-entrapped alginate hollow fibers as a biocatalytic microchemical reactor for chemical synthesis is also deliberated in this article. To ensure that there is no enzyme leaching from the fiber, fiber surfaces were coated with chitosan. To confine the mobility of reactants and products within the porous hollow fibers the entire fibers were embedded into a transparent polydimethylsiloxane (PDMS) matrix which also works as a support matrix. A vanadium-containing bromoperoxidase enzyme isolated from Corallina confusa was used as a model enzyme to demonstrate the use of these alginate hollow-fiber reactors in bromo-oxidation of phenol red to bromophenol blue at different dye flow rates. Stability of the entrapped enzyme at different temperatures and the effect of the chitosan coating on the reaction conversion were also studied. It was observed that molecules as big as 27 kDa can be retained in the matrix after coating with chitosan while molecules with molecular-weight of around 378 Da can still diffuse in and out of the matrix. The kinetic conversion rate in this microfluidic bioreactor was more than 41-fold faster when compared with the standard test-tube procedure. PMID:21799723

Evolution of language: Lessons from the genome.

PubMed

Fisher, Simon E

2017-02-01

The post-genomic era is an exciting time for researchers interested in the biology of speech and language. Substantive advances in molecular methodologies have opened up entire vistas of investigation that were not previously possible, or in some cases even imagined. Speculations concerning the origins of human cognitive traits are being transformed into empirically addressable questions, generating specific hypotheses that can be explicitly tested using data collected from both the natural world and experimental settings. In this article, I discuss a number of promising lines of research in this area. For example, the field has begun to identify genes implicated in speech and language skills, including not just disorders but also the normal range of abilities. Such genes provide powerful entry points for gaining insights into neural bases and evolutionary origins, using sophisticated experimental tools from molecular neuroscience and developmental neurobiology. At the same time, sequencing of ancient hominin genomes is giving us an unprecedented view of the molecular genetic changes that have occurred during the evolution of our species. Synthesis of data from these complementary sources offers an opportunity to robustly evaluate alternative accounts of language evolution. Of course, this endeavour remains challenging on many fronts, as I also highlight in the article. Nonetheless, such an integrated approach holds great potential for untangling the complexities of the capacities that make us human.

Interdependence between crude oil and world food prices: A detrended cross correlation analysis

NASA Astrophysics Data System (ADS)

Pal, Debdatta; Mitra, Subrata K.

2018-02-01

This article explores the changing interdependence between crude oil and world food prices at varying time scales using detrended cross correlation analysis that would answer whether the interdependence (if any) differed significantly between pre and post-crisis period. Unlike the previous studies that exogenously imposed break dates for dividing the time series into sub-samples, we tested whether the mean of the crude oil price changed over time to find evidence for structural changes in the crude oil price series and endogenously determine three break dates with minimum Bayesian information criterion scores. Accordingly, we divided the entire study period in four sample periods - January 1990 to October 1999, November 1999 to February 2005, March 2005 to September 2010, and October 2010 to July 2016, where the third sample period coincided with the period of food crisis and enabled us to compare the fuel-food interdependence across pre-crisis, during the crisis, and post-crisis periods. The results of the detrended cross correlation analysis extended corroborative evidence for increasing positive interdependence between the crude oil price and world food price index along with its sub-categories, namely dairy, cereals, vegetable oil, and sugar. The article ends with the implications of these results in the domain of food policy and the financial sector.

I performed experiments and I have results. Wow, and now?

PubMed Central

Padulo, Johnny; De Giorgio, Andrea; Oliva, Francesco; Frizziero, Antonio; Maffulli, Nicola

2017-01-01

Summary Writing a scientific article is not an easy task, but it is definitely a great satisfaction to be able to conclude and publish it. Indeed, each publication is a service we make to the entire scientific community and to the advancement of science even before our personal career. There is and there will not be a final book/article for writing a scientific paper. Therefore, some knowledge is a decisive factor to increase the chances of our work being accepted by a specialized scientific journal. The purpose of this editorial is to trace an ideal path, based on our personal experience, useful to properly structure a scientific article, from bibliographic research to cover letter. Articles should not be written in a polished way to gratify one’s own ego, but they must be written for anyone who can read and understand them. Level of evidence V. PMID:29387632

Psychological stress associated with cardiogenetic conditions.

PubMed

Hidayatallah, Nadia; Silverstein, Louise B; Stolerman, Marina; McDonald, Thomas; Walsh, Christine A; Paljevic, Esma; Cohen, Lilian L; Marion, Robert W; Wasserman, David; Hreyo, Sarah; Dolan, Siobhan M

2014-09-01

Genetic testing now makes it possible to identify specific mutations that may lead to life-threatening cardiac arrhythmias. This article presents data from a qualitative research study that explored the subjective experiences of individuals and families with cardiogenetic conditions. We focus on describing patients' experiences of psychological stresses associated with having a cardiogenetic condition, illustrating the importance of integrating psychological and medical care. This integration of care is particularly important as personalized genomic medicine continues to evolve and the implications of genetic testing have a profound effect on individuals and families. The researchers interviewed 50 participants from 32 families. The research team used a systematic, grounded theory procedure to code and analyze interview and focus group transcripts, incorporating multiple coders at several stages of the data analysis process. Three major themes emerged: a bereavement trajectory associated with sudden death in the absence of prior symptoms; high anxiety about transmitting a genetic mutation; and resilience reflected in positive lifestyle changes and participation in support groups. This article identifies patient perspectives on personalized genomic medicine in cardiogenetics that can improve clinical care, including: specialized bereavement counseling; improving education about cardiogenetic conditions for medical professionals; parent guidelines for discussing cardiogenetic conditions with their children; information about support groups; and the routine inclusion of clinical psychologists in interdisciplinary treatment teams. Given recent advances in technology and decreasing costs, whole-genome sequencing is likely to become common practice in the near future. Therefore, these recommendations are likely to be relevant for other genetic conditions, as well as the entire field of personalized genomic medicine.

Detection of genome-wide copy number variants in myeloid malignancies using next-generation sequencing.

PubMed

Shen, Wei; Paxton, Christian N; Szankasi, Philippe; Longhurst, Maria; Schumacher, Jonathan A; Frizzell, Kimberly A; Sorrells, Shelly M; Clayton, Adam L; Jattani, Rakhi P; Patel, Jay L; Toydemir, Reha; Kelley, Todd W; Xu, Xinjie

2018-04-01

Genetic abnormalities, including copy number variants (CNV), copy number neutral loss of heterozygosity (CN-LOH) and gene mutations, underlie the pathogenesis of myeloid malignancies and serve as important diagnostic, prognostic and/or therapeutic markers. Currently, multiple testing strategies are required for comprehensive genetic testing in myeloid malignancies. The aim of this proof-of-principle study was to investigate the feasibility of combining detection of genome-wide large CNVs, CN-LOH and targeted gene mutations into a single assay using next-generation sequencing (NGS). For genome-wide CNV detection, we designed a single nucleotide polymorphism (SNP) sequencing backbone with 22 762 SNP regions evenly distributed across the entire genome. For targeted mutation detection, 62 frequently mutated genes in myeloid malignancies were targeted. We combined this SNP sequencing backbone with a targeted mutation panel, and sequenced 9 healthy individuals and 16 patients with myeloid malignancies using NGS. We detected 52 somatic CNVs, 11 instances of CN-LOH and 39 oncogenic mutations in the 16 patients with myeloid malignancies, and none in the 9 healthy individuals. All CNVs and CN-LOH were confirmed by SNP microarray analysis. We describe a genome-wide SNP sequencing backbone which allows for sensitive detection of genome-wide CNVs and CN-LOH using NGS. This proof-of-principle study has demonstrated that this strategy can provide more comprehensive genetic profiling for patients with myeloid malignancies using a single assay. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

16 CFR 1203.16 - Dynamic strength of retention system test.

Code of Federal Regulations, 2011 CFR

2011-01-01

... stirrup. (2) Mark the pre-test position of the retention system, with the entire dynamic test apparatus... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Dynamic strength of retention system test... retention system test. (a) Test equipment. (1) ISO headforms without the lower chin portion shall be used...

16 CFR 1203.16 - Dynamic strength of retention system test.

Code of Federal Regulations, 2010 CFR

2010-01-01

... stirrup. (2) Mark the pre-test position of the retention system, with the entire dynamic test apparatus... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Dynamic strength of retention system test... retention system test. (a) Test equipment. (1) ISO headforms without the lower chin portion shall be used...

16 CFR 1203.16 - Dynamic strength of retention system test.

Code of Federal Regulations, 2014 CFR

2014-01-01

... stirrup. (2) Mark the pre-test position of the retention system, with the entire dynamic test apparatus... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Dynamic strength of retention system test... retention system test. (a) Test equipment. (1) ISO headforms without the lower chin portion shall be used...

16 CFR 1203.16 - Dynamic strength of retention system test.

Code of Federal Regulations, 2012 CFR

2012-01-01

... stirrup. (2) Mark the pre-test position of the retention system, with the entire dynamic test apparatus... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Dynamic strength of retention system test... retention system test. (a) Test equipment. (1) ISO headforms without the lower chin portion shall be used...

16 CFR § 1203.16 - Dynamic strength of retention system test.

Code of Federal Regulations, 2013 CFR

2013-01-01

... stirrup. (2) Mark the pre-test position of the retention system, with the entire dynamic test apparatus... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Dynamic strength of retention system test. Â... retention system test. (a) Test equipment. (1) ISO headforms without the lower chin portion shall be used...

Don’t fence us in

USGS Publications Warehouse

Oliver, J.

1991-01-01

When I was a graduate student around 1950 I used to read the entire Bulletin of the Seismological Society of America. it was a pwoerful and inspiring educational experience, with an effect quite different from that of the more usual process of looking up a few articles in the chain of references in a subject of current interest. Reading the entire journal reveals how ideas, techniques, and seismologists appear and evolve. It is likely the best substitute for a firsthand personal experience with the early development of the field. And in spite of, or perhaps because of, the missteps, the wasted effort, and the lack of sophistication that those first volumes reveal, the reader can sense the opportunity and be inspired by the vibrancy of the young subject. 

The ELT in 2017: The Year of the Primary Mirror

NASA Astrophysics Data System (ADS)

Cirasuolo, M.; Tamai, R.; Cayrel, M.; Koehler, B.; Biancat Marchet, F..; González, J. C.; Dimmler, M.; Tuti, M.; ELT Team

2018-03-01

The Extremely Large Telescope (ELT) is at the core of ESO's vision to deliver the largest optical and infrared telescope in the world. With its unrivalled sensitivity and angular resolution the ELT will transform our view of the Universe: from exoplanets to resolved stellar populations, from galaxy evolution to cosmology and fundamental physics. This article focuses on one of the most challenging aspects of the entire programme, the 39-metre primary mirror (M1). 2017 was a particularly intense year for M1, the main highlight being the approval by ESO's Council to proceed with construction of the entire mirror. In addition, several contracts have been placed to ensure that the giant primary mirror will be operational at first light.

Space Shuttle Project

NASA Image and Video Library

1978-10-04

The Shuttle Orbiter Enterprise inside of Marshall Space Flight Center's Dynamic Test Stand for Mated Vertical Ground Vibration tests (MVGVT). The tests marked the first time ever that the entire shuttle complement including Orbiter, external tank, and solid rocket boosters were vertically mated.

A one dimensional numerical approach for computing the eigenmodes of elastic waves in buried pipelines

NASA Astrophysics Data System (ADS)

Duan, Wenbo; Kirby, Ray; Mudge, Peter; Gan, Tat-Hean

2016-12-01

Ultrasonic guided waves are often used in the detection of defects in oil and gas pipelines. It is common for these pipelines to be buried underground and this may restrict the length of the pipe that can be successfully tested. This is because acoustic energy travelling along the pipe walls may radiate out into the surrounding medium. Accordingly, it is important to develop a better understanding of the way in which elastic waves propagate along the walls of buried pipes, and so in this article a numerical model is developed that is suitable for computing the eigenmodes for uncoated and coated buried pipes. This is achieved by combining a one dimensional eigensolution based on the semi-analytic finite element (SAFE) method, with a perfectly matched layer (PML) for the infinite medium surrounding the pipe. This article also explores an alternative exponential complex coordinate stretching function for the PML in order to improve solution convergence. It is shown for buried pipelines that accurate solutions may be obtained over the entire frequency range typically used in long range ultrasonic testing (LRUT) using a PML layer with a thickness equal to the pipe wall thickness. This delivers a fast and computationally efficient method and it is shown for pipes buried in sand or soil that relevant eigenmodes can be computed and sorted in less than one second using relatively modest computer hardware. The method is also used to find eigenmodes for a buried pipe coated with the viscoelastic material bitumen. It was recently observed in the literature that a viscoelastic coating may effectively isolate particular eigenmodes so that energy does not radiate from these modes into the surrounding [elastic] medium. A similar effect is also observed in this article and it is shown that this occurs even for a relatively thin layer of bitumen, and when the shear impedance of the coating material is larger than that of the surrounding medium.

In-situ medical simulation for pre-implementation testing of clinical service in a regional hospital in Hong Kong.

PubMed

Chen, P P; Tsui, N Tk; Fung, A Sw; Chiu, A Hf; Wong, W Cw; Leong, H T; Lee, P Sf; Lau, J Yw

2017-08-01

The implementation of a new clinical service is associated with anxiety and challenges that may prevent smooth and safe execution of the service. Unexpected issues may not be apparent until the actual clinical service commences. We present a novel approach to test the new clinical setting before actual implementation of our endovascular aortic repair service. In-situ simulation at the new clinical location would enable identification of potential process and system issues prior to implementation of the service. After preliminary planning, a simulation test utilising a case scenario with actual simulation of the entire care process was carried out to identify any logistic, equipment, settings or clinical workflow issues, and to trial a contingency plan for a surgical complication. All patient care including anaesthetic, surgical, and nursing procedures and processes were simulated and tested. Overall, 17 vital process and system issues were identified during the simulation as potential clinical concerns. They included difficult patient positioning, draping pattern, unsatisfactory equipment setup, inadequate critical surgical instruments, blood products logistics, and inadequate nursing support during crisis. In-situ simulation provides an innovative method to identify critical deficiencies and unexpected issues before implementation of a new clinical service. Life-threatening and serious practical issues can be identified and corrected before formal service commences. This article describes our experience with the use of simulation in pre-implementation testing of a clinical process or service. We found the method useful and would recommend it to others.

Green metacycles of attention: Reassessing the attention cycles of environmental news reporting 1961-2010.

PubMed

Djerf-Pierre, Monika

2013-05-01

This article examines the longitudinal development of environmental news reporting in Swedish television over an extended period of time, 1961-2010. It returns to Anthony Downs's (1972) seminal article on issue attention cycles when analyzing the cyclic nature of environmental news reporting and advances the issue attention cycle framework by introducing the concept of metacycles as it explores the trajectory of environmental news reporting. Metacycles refers to the major fluctuations in attention to the entire domain of environmental issues over time, while issue cycles refer to the oscillation in attention pertaining to single issues. The article analyzes the pattern of the metacycles, and investigates how cycles of attention to individual issues contribute to the shaping of the environmental metacycles in the news.

Half-century archives of occupational medical data on French nuclear workers: a dusty warehouse or gold mine for epidemiological research?

PubMed

Garsi, Jerome-Philippe; Samson, Eric; Chablais, Laetitia; Zhivin, Sergey; Niogret, Christine; Laurier, Dominique; Guseva Canu, Irina

2014-12-01

This article discusses the availability and completeness of medical data on workers from the AREVA NC Pierrelatte nuclear plant and their possible use in epidemiological research on cardiovascular and metabolic disorders related to internal exposure to uranium. We created a computer database from files on 394 eligible workers included in an ongoing nested case-control study from a larger cohort of 2897 French nuclear workers. For each worker, we collected records of previous employment, job positions, job descriptions, medical visits, and blood test results from medical history. The dataset counts 9,471 medical examinations and 12,735 blood test results. For almost all of the parameters relevant for research on cardiovascular risk, data completeness and availability is over 90%, but it varies with time and improves in the latest time period. In the absence of biobanks, collecting and computerising available good-quality occupational medicine archive data constitutes a valuable alternative for epidemiological and aetiological research in occupational health. Biobanks rarely contain biological samples over an entire worker's carrier and medical data from nuclear industry archives might make up for unavailable biomarkers that could provide information on cardiovascular and metabolic diseases.

Global and Local Stress Analyses of McDonnell Douglas Stitched/RFI Composite Wing Stub Box

NASA Technical Reports Server (NTRS)

Wang, John T.

1996-01-01

This report contains results of structural analyses performed in support of the NASA structural testing of an all-composite stitched/RFI (resin film infusion) wing stub box. McDonnell Douglas Aerospace Company designed and fabricated the wing stub box. The analyses used a global/local approach. The global model contains the entire test article. It includes the all-composite stub box, a metallic load-transition box and a metallic wing-tip extension box. The two metallic boxes are connected to the inboard and outboard ends of the composite wing stub box, respectively. The load-transition box was attached to a steel and concrete vertical reaction structure and a load was applied at the tip of the extension box to bend the wing stub box upward. The local model contains an upper cover region surrounding three stringer runouts. In that region, a large nonlinear deformation was identified by the global analyses. A more detailed mesh was used for the local model to obtain more accurate analysis results near stringer runouts. Numerous analysis results such as deformed shapes, displacements at selected locations, and strains at critical locations are included in this report.

Designing in the social context: using the social contextual model of health behavior change to develop a tobacco control intervention for teachers in India

PubMed Central

Nagler, Eve M.; Pednekar, Mangesh S.; Viswanath, Kasisomayajula; Sinha, Dhirendra N.; Aghi, Mira B.; Pischke, Claudia R.; Ebbeling, Cara B.; Lando, Harry A.; Gupta, Prakash C.

2013-01-01

This article provides a theory-based, step-by-step approach to intervention development and illustrates its application in India to design an intervention to promote tobacco-use cessation among school personnel in Bihar. We employed a five-step approach to develop the intervention using the Social Contextual Model of Health Behavior Change (SCM) in Bihar, which involved conducting formative research, classifying factors in the social environment as mediating mechanisms and modifying conditions, developing a creative brief, designing an intervention and refining the intervention based on pilot test results. The intervention engages users and non-users of tobacco, involves teachers in implementing and monitoring school tobacco control policies and maximizes teachers’ role as change agents in schools and communities. Intervention components include health educator visits, discussions led by lead teachers, cessation assistance, posters and other educational materials and is implemented over the entire academic year. The intervention is being tested in Bihar government schools as part of a randomized-controlled trial. SCM was a useful framework for developing a tobacco control intervention that responded to teachers’ lives in Bihar. PMID:22669010

Can We Play "Fun Gay"? Disjuncture and Difference, and the Precarious Mobilities of Millennial Queer Youth Narratives

ERIC Educational Resources Information Center

Bryson, Mary K.; MacIntosh, Lori B.

2010-01-01

This article takes up the complex project of unthinking neoliberal accounts of a progressive modernity. The authors position their anxieties about an "after" to queer as an affect modality productive of both an opportunity and an obligation to think critically about the move to delimit historically, and as a gesture to an entirely different…

Ethnic Background and the Transition from Vocational Education to Work: A Multi-Level Analysis of the Differences in Labour Market Outcomes

ERIC Educational Resources Information Center

Brekke, Idunn

2007-01-01

This article focuses on the impact of ethnic background on employment and earnings among people with a vocational education in Norway. I differentiate between three different groups: majority, first-generation non-Westerners and second-generation non-Westerners. Panel data from several public register databases of the entire population of…

The Identity Construction Experiences of Early Career English Language Teachers in Hong Kong. Great Expectations and Practical Realities

ERIC Educational Resources Information Center

Trent, John

2016-01-01

This article reports the results of a multiple qualitative case study which investigated the challenges that seven early career English language teachers in Hong Kong confronted as they constructed their professional and personal identities. A series of in-depth interviews with participants during the entire first year of their full-time teaching…

Economic Assessment of Rural District Heating by Bio-Steam Supplied by a Paper Mill in Canada

ERIC Educational Resources Information Center

Marinova, Mariya; Beaudry, Catherine; Taoussi, Abdelaziz; Trepanier, Martin; Paris, Jean

2008-01-01

The article investigates the feasibility of district heating in a small town adjacent to a Kraft pulp mill in eastern Canada. A detailed heat demand analysis is performed for all buildings using a geographical information system and archived data provided by the municipality. The study shows that the entire space heating requirement of the town…

All Hands on Deck: Organizing for the Schools Saint Paul Children Deserve

ERIC Educational Resources Information Center

Fought, Eric S.

2015-01-01

This article describes a group of dedicated educators who, in the midst of a constant barrage of attacks, dramatically changed the conversation. It is the story of a union that recognized that, in order to bring about the transformation necessary for the betterment of the entire community, its members needed to transform the way in which it…

Forest Plots in Excel: Moving beyond a Clump of Trees to a Forest of Visual Information

ERIC Educational Resources Information Center

Derzon, James H.; Alford, Aaron A.

2013-01-01

Forest plots provide an effective means of presenting a wealth of information in a single graphic. Whether used to illustrate multiple results in a single study or the cumulative knowledge of an entire field, forest plots have become an accepted and generally understood way of presenting many estimates simultaneously. This article explores…

Developing a Culture of Readers through Effective Library Planning

ERIC Educational Resources Information Center

Wejrowski, Kay; McRae, Mat

2013-01-01

In this article, the authors describe how they created a school library that is the center of learning in their school community with the collaborative vision of the principal (Mat McRae) and the school librarian (Kay Wejrowski) and the support of their entire staff. For eight years, McRae and Wejrowski have worked together as principal and school…

From chaos to control: winning the war.

PubMed

Wojciak, P J

1994-08-01

This article illustrates how a small manufacturing facility in the Midwest undertook the process of an MRP II implementation and ultimately gained class A status at a true make-or-break time in its history. The control that was gained throughout the entire process has helped create a winning environment and will continue to strengthen our position as we move toward world-class excellence.

How School Leaders Might Promote Higher Levels of Collective Teacher Efficacy at the Level of School and Team

ERIC Educational Resources Information Center

Prelli, Gail E.

2016-01-01

Leaders search for effective leadership practices to ensure success. A quantitative study was conducted to determine what behaviors a leader could use to improve collective teacher efficacy at the level of the entire faculty and at the level of grade level teams. This article focuses on using the inverse relationship between transformational…

Following the Yellow Brick Road to Simplified Link Management

ERIC Educational Resources Information Center

Engard, Nicole C.

2005-01-01

Jenkins Law Library is the oldest law library in America, and has a reputation for offering great content not only to local attorneys, but also to the entire legal research community. In this article, the author, who is Web manager at Jenkins, describes the development of an automated process by which research links can be added to the database so…

Adaptation of a Pocket PC for Use as a Wearable Voice Dosimeter

ERIC Educational Resources Information Center

Popolo, Peter S.; Svec, Jan G.; Titze, Ingo R.

2005-01-01

This article deals with the adaptation of a commercially available Pocket PC for use as a voice dosimeter, a wearable device that measures the vocal dose of teachers or other individuals on the job, at home, and elsewhere during the course of an entire day. An engineering approach for designing a voice dosimeter is described, and design data are…

40 CFR 86.345-79 - Emission calculations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... gasoline-fueled engine test from the pre-test data. Apply the Y value to the K W equation for the entire test. (5) Calculate a separate Y value for each Diesel test segment from the pretest-segment data... New Gasoline-Fueled and Diesel-Fueled Heavy-Duty Engines; Gaseous Exhaust Test Procedures § 86.345-79...

40 CFR 86.345-79 - Emission calculations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... gasoline-fueled engine test from the pre-test data. Apply the Y value to the K W equation for the entire test. (5) Calculate a separate Y value for each Diesel test segment from the pretest-segment data... New Gasoline-Fueled and Diesel-Fueled Heavy-Duty Engines; Gaseous Exhaust Test Procedures § 86.345-79...

40 CFR 86.345-79 - Emission calculations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... gasoline-fueled engine test from the pre-test data. Apply the Y value to the K W equation for the entire test. (5) Calculate a separate Y value for each Diesel test segment from the pretest-segment data... New Gasoline-Fueled and Diesel-Fueled Heavy-Duty Engines; Gaseous Exhaust Test Procedures § 86.345-79...

40 CFR 86.345-79 - Emission calculations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... gasoline-fueled engine test from the pre-test data. Apply the Y value to the K W equation for the entire test. (5) Calculate a separate Y value for each Diesel test segment from the pretest-segment data... New Gasoline-Fueled and Diesel-Fueled Heavy-Duty Engines; Gaseous Exhaust Test Procedures § 86.345-79...

US-23 aggregate test road long-term performance evaluation : final report.

DOT National Transportation Integrated Search

2017-03-24

The US-23 Aggregate Test Road was constructed in 1992 with the main purpose to determine the influence of coarse : aggregate of varying frost susceptibility on long-term concrete durability. The pavement structure for the entire Test Road consists : ...

Space Shuttle Project

NASA Image and Video Library

1978-04-21

The Shuttle Orbiter Enterprise is lowered into the Dynamic Test Stand for Mated Vertical Ground Vibration tests (MVGVT) at the Marshall Space Flight Center. The tests marked the first time ever that the entire shuttle complement (including Orbiter, external tank, and solid rocket boosters) were mated vertically.

Space Shuttle Project

NASA Image and Video Library

1978-10-04

The Shuttle Orbiter Enterprise is being installed into liftoff configuration at Marshall Space Flight Center's Dynamic Test Stand for Mated Vertical Ground Vibration tests (MVGVT). The tests marked the first time ever that the entire shuttle complement (including Orbiter, external tank, and solid rocket boosters) were mated vertically.

Advanced Networks in Motion Mobile Sensorweb

NASA Technical Reports Server (NTRS)

Ivancic, William D.; Stewart, David H.

2011-01-01

Advanced mobile networking technology applicable to mobile sensor platforms was developed, deployed and demonstrated. A two-tier sensorweb design was developed. The first tier utilized mobile network technology to provide mobility. The second tier, which sits above the first tier, utilizes 6LowPAN (Internet Protocol version 6 Low Power Wireless Personal Area Networks) sensors. The entire network was IPv6 enabled. Successful mobile sensorweb system field tests took place in late August and early September of 2009. The entire network utilized IPv6 and was monitored and controlled using a remote Web browser via IPv6 technology. This paper describes the mobile networking and 6LowPAN sensorweb design, implementation, deployment and testing as well as wireless systems and network monitoring software developed to support testing and validation.

Seal coat binder performance specifications.

DOT National Transportation Integrated Search

2013-11-01

Need to improve seal coat binder specs: replace empirical tests (penetration, ductility) with : performance-related tests applicable to both : unmodified and modified binders; consider temperatures that cover entire in service : range that are tied t...

A record of large earthquakes on the southern Hayward fault for the past 1800 years

USGS Publications Warehouse

Lienkaemper, J.J.; Williams, P.L.

2007-01-01

This is the second article presenting evidence of the occurrence and timing of paleoearthquakes on the southern Hayward fault as interpreted from trenches excavated within a sag pond at the Tyson's Lagoon site in Fremont, California. We use the information to estimate the mean value and aperiodicity of the fault's recurrence interval (RI): two fundamental parameters for estimation of regional seismic hazard. An earlier article documented the four most recent earthquakes, including the historic 1868 earthquake. In this article we present evidence for at least seven earlier paleoruptures since about A.D. 170. We document these events with evidence for ground rupture, such as the presence of blocky colluvium at the base of the main trace fault scarp, and by corroborating evidence such as simultaneous liquefaction or an increase in deformation immediately below event horizons. The mean RI is 170 ?? 82 yr (1??, standard deviation of the sample), aperiodicity is 0.48, and individual intervals may be expected to range from 30 to 370 yr (95.4% confidence). The mean RI is consistent with the recurrence model of the Working Group on California Earthquake Probabilities (2003) (mean, 161 yr; range, 99 yr [2.5%]; 283 yr [97.5%]). We note that the mean RI for the five most recent events may have been only 138 ?? 58 yr (1??). Hypothesis tests for the shorter RI do not demonstrate that any recent acceleration has occurred compared to the earlier period or the entire 1800-yr record, principally because of inherent uncertainties of the event ages.

Meta-analysis of academic interventions derived from neuropsychological data.

PubMed

Burns, Matthew K; Petersen-Brown, Shawna; Haegele, Katherine; Rodriguez, Megan; Schmitt, Braden; Cooper, Maureen; Clayton, Kate; Hutcheson, Shannon; Conner, Cynthia; Hosp, John; VanDerHeyden, Amanda M

2016-03-01

Several scholars have recommended using data from neuropsychological tests to develop interventions for reading and mathematics. The current study examined the effects of using neuropsychological data within the intervention process with meta-analytic procedures. A total of 1,126 articles were found from an electronic search and compared to inclusion criteria, which resulted in 37 articles that were included in the current study. Each article was coded based on how the data were used (screening-86% or designing interventions-14%), size of the group for which interventions were delivered (small group-45%, individual students-45%, or entire classroom-10%), and type of data collected (cognitive functions-24%, reading fluency-33%, phonemic/phonological awareness-35%, or mixed-8%). A corrected Hedges' g was computed for every study and reported for variables of interest. A Fail-safe N was also computed to determine how many studies with a zero effect would have to be found to change the conclusions. The data resulted in a small effect (g = 0.17) for measures of cognitive functioning, but moderate effects of g = 0.43 and g = 0.48 for measures of reading fluency and phonemic/phonological awareness. There were few studies that examined measures of cognitive functioning within the intervention process. Taken together with previous research, the data do not support the use of cognitive measures to develop interventions but instead favor more direct measures of academic skills (e.g., reading fluency) in a skill-by-treatment interaction. Implications for practice and future research are discussed. (c) 2016 APA, all rights reserved).

Improving customer satisfaction: emerging lessons about strategy and implementation, Part 2.

PubMed

Morton, J

1995-01-01

This article describes a six-phase strategy designed to systematically improve customer satisfaction across an entire managed care system. Part 1 (Spring 1995) of this two-part series summarized the theoretical underpinnings of the approach and highlighted the first two phases of the improvement strategy. Those phases involve systematically listening to the organization's customers and using customer information to strategically target key areas for improvement. This article describes the specifics of the last four phases of the strategy; these phases involve achieving and sustaining unprecedented levels of improvement in targeted areas. Initial results and emerging lessons associated with the implementation of this strategy are summarized.

[The analysis of the subject-matter and the structure of scientific articles related to forensic biology published in the journal "Sudebno-meditsinskaya ekspertiza (Forensic Medical Expertise)" in 1960-2010].

PubMed

Gusarov, A A; Shigeev, S V; Fetisov, V A

2015-01-01

This paper reports the results of the analysis of the subject-matter and the structure of scientific articles related to forensic biology published in the journal "Sudebno-meditsinskaya ekspertiza" over the period from 1960 till 2010. The sceintometric analysis made it possible to distinguish the main avenues along which forensic biology developed during its most productive period. The results of this analytical study have provided in the summarized form the entire spectrum of the main trends in the forensic biology throughout the half-century period.

The Vocational Significance of Black Identity: Cultural Formulation Approach to Career Assessment and Career Counseling

PubMed Central

Byars-Winston, Angela M.

2010-01-01

Scholarship is emerging on intervention models that purposefully attend to cultural variables throughout the career assessment and career counseling process (Swanson & Fouad, in press). One heuristic model that offers promise to advance culturally-relevant vocational practice with African Americans is the Outline for Cultural Formulation (American Psychiatric Association, 1994). This article explicates the Outline for Cultural Formulation in career assessment and career counseling with African Americans integrating the concept of cultural identity into the entire model. The article concludes with an illustration of the Outline for Cultural Formulation model with an African American career client. PMID:20495668

Gender-Blind Sexism and Rape Myth Acceptance.

PubMed

Stoll, Laurie Cooper; Lilley, Terry Glenn; Pinter, Kelly

2017-01-01

The purpose of this article is to explore whether gender-blind sexism, as an extension of Bonilla-Silva's racialized social system theory, is an appropriate theoretical framework for understanding the creation and continued prevalence of rape myth acceptance. Specifically, we hypothesize that individuals who hold attitudes consistent with the frames of gender-blind sexism are more likely to accept common rape myths. Data for this article come from an online survey administered to the entire undergraduate student body at a large Midwestern institution (N = 1,401). Regression analysis showed strong support for the effects of gender-blind sexism on rape myth acceptance. © The Author(s) 2016.

21 CFR 58.107 - Test and control article handling.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Test and control article handling. 58.107 Section... GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.107 Test and control article handling. Procedures shall be established for a system for the handling of the test and...

21 CFR 58.107 - Test and control article handling.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Test and control article handling. 58.107 Section... GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.107 Test and control article handling. Procedures shall be established for a system for the handling of the test and...

21 CFR 58.107 - Test and control article handling.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Test and control article handling. 58.107 Section... GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.107 Test and control article handling. Procedures shall be established for a system for the handling of the test and...

21 CFR 58.107 - Test and control article handling.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Test and control article handling. 58.107 Section... GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.107 Test and control article handling. Procedures shall be established for a system for the handling of the test and...

Executive functioning in schizophrenia: Unique and shared variance with measures of fluid intelligence.

PubMed

Martin, A K; Mowry, B; Reutens, D; Robinson, G A

2015-10-01

Patients with schizophrenia often display deficits on tasks thought to measure "executive" processes. Recently, it has been suggested that reductions in fluid intelligence test performance entirely explain deficits reported for patients with focal frontal lesions on classical executive tasks. For patients with schizophrenia, it is unclear whether deficits on executive tasks are entirely accountable by fluid intelligence and representative of a common general process or best accounted for by distinct contributions to the cognitive profile of schizophrenia. In the current study, 50 patients with schizophrenia and 50 age, sex and premorbid intelligence matched controls were assessed using a broad neuropsychological battery, including tasks considered sensitive to executive abilities, namely the Hayling Sentence Completion Test (HSCT), word fluency, Stroop test, digit-span backwards, and spatial working memory. Fluid intelligence was measured using both the Matrix reasoning subtest from the Weschler Abbreviated Scale of Intelligence (WASI) and a composite score derived from a number of cognitive tests. Patients with schizophrenia were impaired on all cognitive measures compared with controls, except smell identification and the optimal betting and risk-taking measures from the Cambridge Gambling Task. After introducing fluid intelligence as a covariate, significant differences remained for HSCT suppression errors, and classical executive function tests such as the Stroop test and semantic/phonemic word fluency, regardless of which fluid intelligence measure was included. Fluid intelligence does not entirely explain impaired performance on all tests considered as reflecting "executive" processes. For schizophrenia, these measures should remain part of a comprehensive neuropsychological assessment alongside a measure of fluid intelligence. Copyright © 2015 Elsevier Inc. All rights reserved.

Alternative Vocabularies in the Test Validity Literature

ERIC Educational Resources Information Center

Markus, Keith A.

2016-01-01

Justification of testing practice involves moving from one state of knowledge about the test to another. Theories of test validity can (a) focus on the beginning of the process, (b) focus on the end, or (c) encompass the entire process. Analyses of four case studies test and illustrate three claims: (a) restrictions on validity entail a supplement…

Computational tools and resources for metabolism-related property predictions. 1. Overview of publicly available (free and commercial) databases and software.

PubMed

Peach, Megan L; Zakharov, Alexey V; Liu, Ruifeng; Pugliese, Angelo; Tawa, Gregory; Wallqvist, Anders; Nicklaus, Marc C

2012-10-01

Metabolism has been identified as a defining factor in drug development success or failure because of its impact on many aspects of drug pharmacology, including bioavailability, half-life and toxicity. In this article, we provide an outline and descriptions of the resources for metabolism-related property predictions that are currently either freely or commercially available to the public. These resources include databases with data on, and software for prediction of, several end points: metabolite formation, sites of metabolic transformation, binding to metabolizing enzymes and metabolic stability. We attempt to place each tool in historical context and describe, wherever possible, the data it was based on. For predictions of interactions with metabolizing enzymes, we show a typical set of results for a small test set of compounds. Our aim is to give a clear overview of the areas and aspects of metabolism prediction in which the currently available resources are useful and accurate, and the areas in which they are inadequate or missing entirely.

Assessment of the intraday variability of anthropometric measurements in the work environment: a pilot study.

PubMed

Bragança, Sara; Arezes, Pedro; Carvalho, Miguel; Ashdown, Susan P; Leão, Celina

2017-05-19

Sitting for long periods of time, both during work and leisure times, is the typical behavior of the modern society. Especially at work, where there is not much flexibility, adopting the sitting posture for the entire day can cause some short-term and long-term effects. As workers' productivity and well-being relies on working conditions, evaluating the effects caused by work postures assumes a very important role. The purpose of this article was to evaluate the variation of some anthropometric measurements during one typical workday to understand whether the known long-term effects can also be seen and quantified in an 8-h period. Twenty participants were measured before and after work, using traditional anthropometry equipment. The data from the two repetitions were compared using statistical tests. The results showed a slight variation in the anthropometric measurements, some with a tendency to increase over time and others with a tendency to decrease.

Evaluation Aspects of Building Structures Reconstructed After a Failure or Catastrophe

NASA Astrophysics Data System (ADS)

Krentowski, Janusz R.; Knyziak, Piotr

2017-10-01

The article presents the characteristics of several steel structures, among others modernized industrial dye house, school sports hall, truck repair workshop, that have been rebuilt after a disaster or a catastrophe. The structures were analyzed in detail, and the evaluation and reconstruction processes were described. The emergencies that occurred during exploitation of the buildings were the result of multiple mistakes: incorrectly defined intervals between inspections, errors during periodic inspections, incorrect repair work recommendations. The concepts of reinforcement work implemented by the authors, enabling the long-term future failure-free operation of the objects, were presented. Recommendations for monitoring of the facilities, applied after reinforcement or reconstruction, have been formulated. The methodology for the implementation of specialized investigations, such as geodetic, optical, geological, chemical strength tests, both destructive and non-destructive, has been defined. The need to determine the limit values of deformations, deflections, damage or other faults of structural elements and the entire rebuilt facilities, as well as defining conditions for objects’ withdrawal from operation in subsequent exceptional situations was indicated.

Transient flow analysis linked to fast pressure disturbance monitored in pipe systems

NASA Astrophysics Data System (ADS)

Kueny, J. L.; Lourenco, M.; Ballester, J. L.

2012-11-01

EDF Hydro Division has launched the RENOUVEAU program in order to increase performance and improve plant availability through anticipation. Due to this program, a large penstocks fleet is equipped with pressure transducers linked to a special monitoring system. Any significant disturbance of the pressure is captured in a snapshot and the waveform of the signal is stored and analyzed. During these transient states, variations in flow are unknown. In order to determine the structural impact of such overpressure occurring during complex transients conditions over the entire circuit, EDF DTG has asked ENSE3 GRENOBLE to develop a code called ACHYL CF*. The input data of ACHYL CF are circuit topology and pressure boundaries conditions. This article provide a description of the computer code developed for modeling the transient flow in a pipe network using the signals from pressure transducers as boundary conditions. Different test cases will be presented, simulating real hydro power plants for which measured pressure signals are available.

Dental Pulp and Dentin Tissue Engineering and Regeneration – Advancement and Challenge

PubMed Central

Huang, George T.-J.

2012-01-01

Hard tissue is difficult to repair especially dental structures. Tooth enamel is incapable of self-repairing whereas dentin and cememtum can regenerate with limited capacity. Enamel and dentin are commonly under the attack by caries. Extensive forms of caries destroy enamel and dentin and can lead to dental pulp infection. Entire pulp amputation followed by the pulp space disinfection and filled with an artificial rubber-like material is employed to treat the infection --commonly known as root canal or endodontic therapy. Regeneration of dentin relies on having vital pulps; however, regeneration of pulp tissue has been difficult as the tissue is encased in dentin without collateral blood supply except from the root apical end. With the advent of modern tissue engineering concept and the discovery of dental stem cells, regeneration of pulp and dentin has been tested. This article will review the recent endeavor on pulp and dentin tissue engineering and regeneration. The prospective outcome of the current advancement and challenge in this line of research will be discussed. PMID:21196351

Recognition of psychotherapy effectiveness: the APA resolution.

PubMed

Campbell, Linda F; Norcross, John C; Vasquez, Melba J T; Kaslow, Nadine J

2013-03-01

In August 2012, the American Psychological Association (APA) Council of Representatives voted overwhelmingly to adopt as APA policy a Resolution on the Recognition of Psychotherapy Effectiveness. This invited article traces the origins and intentions of that resolution and its protracted journey through the APA governance labyrinth. We summarize the planned dissemination and projected results of the resolution and identify several lessons learned through the entire process.

"We Can't Let Them Fail for One More Day": School Reform Urgency and the Politics of Reformer-Community Alliances

ERIC Educational Resources Information Center

Gordon, Hava Rachel

2016-01-01

This article provides a critical examination of neoliberal urgency in education reform. While critics of neoliberal reform policies have argued that these reforms exclude low-income community participation almost entirely, I argue that in practice this exclusion is not as total or as overt as macro-analyses would suggest. These macro analyses do…

78 FR 75645 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing of Proposed Rule Change To...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-12

.... Article Fifth, Paragraph D provides that, except for directors elected by the holders of any series of preferred stock, any director, or the entire Board, may be removed from office at any time, but only by the... deletes obsolete references to the following: The 3.75% Series A Convertible Notes due 2012 and the 3.75...

The Swedish Schoolhouse: A Case Study in Transnational Influences in Education at the 1870s World Fairs

ERIC Educational Resources Information Center

Lundahl, Christian; Lawn, Martin

2015-01-01

At the world exhibitions of the 1870s Sweden displayed a schoolhouse, with examples of teaching material and student work. How did Sweden ship an entire schoolhouse to these exhibitions? What impact did the schoolhouse have on visitors to the exhibition? The purpose of this article is to shed light on the transnational influences operating between…

A Co-Teaching Model: Committed Professionals, High Expectations, and the Inclusive Classroom

ERIC Educational Resources Information Center

Lindeman, Karen Wise; Magiera, Kathleen

2014-01-01

This article relates the story of a first grade teacher and a child who was the only deaf student in the entire school. Because he had no one who could communicate with him--not teachers, not students, no one, this situation tugged at the hearts of a committed team of professionals. A teacher of the deaf, a first grade general education teacher, a…

Laughter as Immanent Life-Affirmation: Reconsidering the Educational Value of Laughter through a Bakhtinian Lens

ERIC Educational Resources Information Center

Vlieghe, Joris

2014-01-01

In this article I try to conceive a new approach towards laughter in the context of formal schooling. I focus on laughter in so far as it is a bodily response during which we are entirely delivered to uncontrollable, spasmodic reactions. To see the educational relevance of this particular kind of laughter, as well as to understand why laughter is…

Leading change: 3--implementation.

PubMed

Kerridge, Joanna

The potential for all staff to contribute to service improvement, irrespective of discipline, role or function, is outlined in the 2011 NHS leadership framework. This advocates developing the skills of the entire workforce to create a climate of continuous service improvement. As nurses are often required to take the lead in managing change in clinical practice, this final article in a three-part series focuses on implementing ande potentia reviewing change.

Revista de Documentacao de Estudos em Liguistica Teorica e Aplicada, 1998 (Journal of Documentary Studies in Linguistic Theory and Application, 1998).

ERIC Educational Resources Information Center

Barbara, Leila, Ed.; Rajagopalan, Kanavillil, Ed.

1998-01-01

This document consists of three issues of DELTA, comprising its entire output for 1998. DELTA is a journal of theoretical and applied linguistics and covers a wide variety of material related to language, speech, and education. The journal publishes only original research and ideas presented in the form of articles, debates, squibs, overviews,…

The Elephant in the Room: School Districts Nationwide Are Voluntarily Filtering the Filters--And No One Is Talking about It

ERIC Educational Resources Information Center

Bell, Mary Ann

2007-01-01

In this article, the author expresses her disappointment over the self-censorship being practiced by some schools. Some schools are only letting students search sites on district-approved lists, while others are imposing stringent time limits on certain sites. In a few extreme cases, schools banned Internet entirely. These practices are blocking…

Risk-based Strategy to Determine Testing Requirement for the Removal of Residual Process Reagents as Process-related Impurities in Bioprocesses.

PubMed

Qiu, Jinshu; Li, Kim; Miller, Karen; Raghani, Anil

2015-01-01

The purpose of this article is to recommend a risk-based strategy for determining clearance testing requirements of the process reagents used in manufacturing biopharmaceutical products. The strategy takes account of four risk factors. Firstly, the process reagents are classified into two categories according to their safety profile and history of use: generally recognized as safe (GRAS) and potential safety concern (PSC) reagents. The clearance testing of GRAS reagents can be eliminated because of their safe use historically and process capability to remove these reagents. An estimated safety margin (Se) value, a ratio of the exposure limit to the estimated maximum reagent amount, is then used to evaluate the necessity for testing the PSC reagents at an early development stage. The Se value is calculated from two risk factors, the starting PSC reagent amount per maximum product dose (Me), and the exposure limit (Le). A worst-case scenario is assumed to estimate the Me value, that is common. The PSC reagent of interest is co-purified with the product and no clearance occurs throughout the entire purification process. No clearance testing is required for this PSC reagent if its Se value is ≥1; otherwise clearance testing is needed. Finally, the point of the process reagent introduction to the process is also considered in determining the necessity of the clearance testing for process reagents. How to use the measured safety margin as a criterion for determining PSC reagent testing at process characterization, process validation, and commercial production stages are also described. A large number of process reagents are used in the biopharmaceutical manufacturing to control the process performance. Clearance testing for all of the process reagents will be an enormous analytical task. In this article, a risk-based strategy is described to eliminate unnecessary clearance testing for majority of the process reagents using four risk factors. The risk factors included in the strategy are (i) safety profile of the reagents, (ii) the starting amount of the process reagents used in the manufacturing process, (iii) the maximum dose of the product, and (iv) the point of introduction of the process reagents in the process. The implementation of the risk-based strategy can eliminate clearance testing for approximately 90% of the process reagents used in the manufacturing processes. This science-based strategy allows us to ensure patient safety and meet regulatory agency expectations throughout the product development life cycle. © PDA, Inc. 2015.

Efficacy of non-fovea-sparing ILM peeling for symptomatic myopic foveoschisis with and without macular hole.

PubMed

Al-Badawi, Amer Hamad; Abdelhakim, Mohamad Amr Salah Eddin; Macky, Tamer Ahmed; Mortada, Hassan Aly

2018-04-30

To study anatomical and visual outcomes of pars plana vitrectomy (PPV) with non-fovea-sparing (entire) internal limiting membrane (ILM) peeling in eyes with myopic foveoschisis (MF). Prospective interventional case series of eyes undergoing PPV with entire ILM peeling for symptomatic MF. Preoperative spectral domain optical coherence tomography (SD - OCT) epiretinal membrane, anomalous posterior vitreous detachment, vitreoschisis and postoperative changes in SD-OCT central foveal thickness (CFT), ellipsoid zone defect, foveal detachment (FD), macular hole (MH) diameter (if present) and best-corrected visual acuity (BCVA) in logarithm of the minimum angle of resolution (logMAR). This study included 21 eyes (21 patients) with mean age 60.4±13.1, 15 females (71.4%). All patients achieved complete postoperative reattachment by SD-OCT (no FD) 6 months post vitrectomy, with no iatrogenic intraoperative or postoperative MH, and with significant improvement in final BCVA from 1.6±0.30 to1.0±0.2 logMAR, and in CFT from 918.2±311.4 to182.3±33.1 µm. Patients were subdivided into subgroup A: 11 eyes without MH; and subgroup B: 10 eyes with MH, the latter had significant improvement in MH diameter (p=0.005). Preoperative BCVA was a significant risk factor for visual gain, while preoperative FD and CFT were significant for CFT change. Vitrectomy with non-fovea-sparing (entire) ILM peeling resulted in a significant functional and anatomical improvement in eyes with MF with/without MH with no reported complications. Results are comparable to fovea-sparing ILM peeling. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

21 CFR 58.105 - Test and control article characterization.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Test and control article characterization. 58.105... GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.105 Test and control article characterization. (a) The identity, strength, purity, and composition or other...

21 CFR 58.105 - Test and control article characterization.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Test and control article characterization. 58.105... GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.105 Test and control article characterization. (a) The identity, strength, purity, and composition or other...

21 CFR 58.105 - Test and control article characterization.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Test and control article characterization. 58.105... GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.105 Test and control article characterization. (a) The identity, strength, purity, and composition or other...

21 CFR 58.105 - Test and control article characterization.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Test and control article characterization. 58.105... GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.105 Test and control article characterization. (a) The identity, strength, purity, and composition or other...

21 CFR 58.105 - Test and control article characterization.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Test and control article characterization. 58.105... GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.105 Test and control article characterization. (a) The identity, strength, purity, and composition or other...

My Stakes Well Done.

ERIC Educational Resources Information Center

Domenech, Daniel A.

2000-01-01

The question of validity, or how high-stakes tests are being used and interpreted, threatens to undermine the entire standards movement. Joint standards developed by three professional associations say decisions affecting students' life chances should not be based on test scores alone. Objectivity and teaching to tests are real concerns. (MLH)

Application of microtomography and image analysis to the quantification of fragmentation in ceramics after impact loading

NASA Astrophysics Data System (ADS)

Forquin, Pascal; Ando, Edward

2017-01-01

Silicon carbide ceramics are widely used in personal body armour and protective solutions. However, during impact, an intense fragmentation develops in the ceramic tile due to high-strain-rate tensile loadings. In this work, microtomography equipment was used to analyse the fragmentation patterns of two silicon carbide grades subjected to edge-on impact (EOI) tests. The EOI experiments were conducted in two configurations. The so-called open configuration relies on the use of an ultra-high-speed camera to visualize the fragmentation process with an interframe time set to 1 µs. The so-called sarcophagus configuration consists in confining the target in a metallic casing to avoid any dispersion of fragments. The target is infiltrated after impact so the final damage pattern is entirely scanned using X-ray tomography and a microfocus source. Thereafter, a three-dimensional (3D) segmentation algorithm was tested and applied in order to separate fragments in 3D allowing a particle size distribution to be obtained. Significant differences between the two specimens of different SiC grades were noted. To explain such experimental results, numerical simulations were conducted considering the Denoual-Forquin-Hild anisotropic damage model. According to the calculations, the difference of crack pattern in EOI tests is related to the population of defects within the two ceramics. This article is part of the themed issue 'Experimental testing and modelling of brittle materials at high strain rates'.

Heat Pipe Reactor Dynamic Response Tests: SAFE-100 Reactor Core Prototype

NASA Technical Reports Server (NTRS)

Bragg-Sitton, Shannon M.

2005-01-01

The SAFE-I00a test article at the NASA Marshall Space Flight Center was used to simulate a variety of potential reactor transients; the SAFEl00a is a resistively heated, stainless-steel heat-pipe (HP)-reactor core segment, coupled to a gas-flow heat exchanger (HX). For these transients the core power was controlled by a point kinetics model with reactivity feedback based on core average temperature; the neutron generation time and the temperature feedback coefficient are provided as model inputs. This type of non-nuclear test is expected to provide reasonable approximation of reactor transient behavior because reactivity feedback is very simple in a compact fast reactor (simple, negative, and relatively monotonic temperature feedback, caused mostly by thermal expansion) and calculations show there are no significant reactivity effects associated with fluid in the HP (the worth of the entire inventory of Na in the core is .

Quality management and accreditation in a mixed research and clinical hair testing analytical laboratory setting-a review.

PubMed

Fulga, Netta

2013-06-01

Quality management and accreditation in the analytical laboratory setting are developing rapidly and becoming the standard worldwide. Quality management refers to all the activities used by organizations to ensure product or service consistency. Accreditation is a formal recognition by an authoritative regulatory body that a laboratory is competent to perform examinations and report results. The Motherisk Drug Testing Laboratory is licensed to operate at the Hospital for Sick Children in Toronto, Ontario. The laboratory performs toxicology tests of hair and meconium samples for research and clinical purposes. Most of the samples are involved in a chain of custody cases. Establishing a quality management system and achieving accreditation became mandatory by legislation for all Ontario clinical laboratories since 2003. The Ontario Laboratory Accreditation program is based on International Organization for Standardization 15189-Medical laboratories-Particular requirements for quality and competence, an international standard that has been adopted as a national standard in Canada. The implementation of a quality management system involves management commitment, planning and staff education, documentation of the system, validation of processes, and assessment against the requirements. The maintenance of a quality management system requires control and monitoring of the entire laboratory path of workflow. The process of transformation of a research/clinical laboratory into an accredited laboratory, and the benefits of maintaining an effective quality management system, are presented in this article.

Cholangiocarcinoma

MedlinePlus

... microscope Blood tests that may be done include: Liver function tests (especially alkaline phosphatase or bilirubin levels) Complete blood count (CBC) Treatment ... and may result in a cure. If the tumor is large, the entire liver may need to be removed and a liver ...

Automotive collision avoidance system field operational test

DOT National Transportation Integrated Search

2005-03-01

The Automotive Collision Avoidance System field operational test (or ACAS FOT) program was led by General Motors (GM) under a cooperative agreement with the U.S. Department of Transportation. This report summarizes the activities of the entire progra...

Qualification Motor no. 8 (QM-8), volume 1

NASA Technical Reports Server (NTRS)

Garecht, D. M.

1989-01-01

All inspection and instrumentation data indicate that the QM-8 static test firing conducted 20 January 1989 was successful. Ambient temperature at T-0 was 28 F. With two flights successfully accomplished, this final test in the redesigned solid rocket motor (RSRM) program certified that the design meets motor performance requirements under extreme cold conditions. This test was a prerequisite to the third flight. The entire test article was cold conditioned at 20 to 25 F for approximately 31 days to assure a maximum propellant mean bulk temperature (PMBT) of 40 F, making it the lowest PMBT in the history of the program. This extreme condition also presented the opportunity to certify critical components at low temperatures. Certification of field joint and igniter heaters, adhesive bondline integrity, flex bearing performance, flight instrumentation performance, RSRM seal performance, and LSC and nozzle plug performance was accomplished. Prior to motor ignition, the field joints were maintained between 75 to 130 F, the igniter-to-case joint was maintained between 75 to 123 F, and the case-to-nozzle joint was maintained between 75 to 120 F. QM-8 was tested with induced side loads to simulate the strut loads experienced during ignition and maximum aerodynamic loading conditions. The ability of the safe and arm device to change position from safe-to-arm and arm-to-safe was certified. Ballistics performance was certified at the lower limits. Values were within specification requirements. Nozzle performance was nominal with typical erosion. The use of Fiberite carbon-cloth phenolic was certified. The water deluge system, CO2 quench, and other test equipment performed as planned during all required test operations.

Automatic force balance calibration system

NASA Technical Reports Server (NTRS)

Ferris, Alice T. (Inventor)

1995-01-01

A system for automatically calibrating force balances is provided. The invention uses a reference balance aligned with the balance being calibrated to provide superior accuracy while minimizing the time required to complete the calibration. The reference balance and the test balance are rigidly attached together with closely aligned moment centers. Loads placed on the system equally effect each balance, and the differences in the readings of the two balances can be used to generate the calibration matrix for the test balance. Since the accuracy of the test calibration is determined by the accuracy of the reference balance and current technology allows for reference balances to be calibrated to within +/-0.05% the entire system has an accuracy of +/-0.2%. The entire apparatus is relatively small and can be mounted on a movable base for easy transport between test locations. The system can also accept a wide variety of reference balances, thus allowing calibration under diverse load and size requirements.

Automatic force balance calibration system

NASA Technical Reports Server (NTRS)

Ferris, Alice T. (Inventor)

1996-01-01

A system for automatically calibrating force balances is provided. The invention uses a reference balance aligned with the balance being calibrated to provide superior accuracy while minimizing the time required to complete the calibration. The reference balance and the test balance are rigidly attached together with closely aligned moment centers. Loads placed on the system equally effect each balance, and the differences in the readings of the two balances can be used to generate the calibration matrix for the test balance. Since the accuracy of the test calibration is determined by the accuracy of the reference balance and current technology allows for reference balances to be calibrated to within .+-.0.05%, the entire system has an accuracy of a .+-.0.2%. The entire apparatus is relatively small and can be mounted on a movable base for easy transport between test locations. The system can also accept a wide variety of reference balances, thus allowing calibration under diverse load and size requirements.

Muscle MRI in patients with dysferlinopathy: pattern recognition and implications for clinical trials.

PubMed

Diaz-Manera, Jordi; Fernandez-Torron, Roberto; LLauger, Jaume; James, Meredith K; Mayhew, Anna; Smith, Fiona E; Moore, Ursula R; Blamire, Andrew M; Carlier, Pierre G; Rufibach, Laura; Mittal, Plavi; Eagle, Michelle; Jacobs, Marni; Hodgson, Tim; Wallace, Dorothy; Ward, Louise; Smith, Mark; Stramare, Roberto; Rampado, Alessandro; Sato, Noriko; Tamaru, Takeshi; Harwick, Bruce; Rico Gala, Susana; Turk, Suna; Coppenrath, Eva M; Foster, Glenn; Bendahan, David; Le Fur, Yann; Fricke, Stanley T; Otero, Hansel; Foster, Sheryl L; Peduto, Anthony; Sawyer, Anne Marie; Hilsden, Heather; Lochmuller, Hanns; Grieben, Ulrike; Spuler, Simone; Tesi Rocha, Carolina; Day, John W; Jones, Kristi J; Bharucha-Goebel, Diana X; Salort-Campana, Emmanuelle; Harms, Matthew; Pestronk, Alan; Krause, Sabine; Schreiber-Katz, Olivia; Walter, Maggie C; Paradas, Carmen; Hogrel, Jean-Yves; Stojkovic, Tanya; Takeda, Shin'ichi; Mori-Yoshimura, Madoka; Bravver, Elena; Sparks, Susan; Bello, Luca; Semplicini, Claudio; Pegoraro, Elena; Mendell, Jerry R; Bushby, Kate; Straub, Volker

2018-05-07

Dysferlinopathies are a group of muscle disorders caused by mutations in the DYSF gene. Previous muscle imaging studies describe a selective pattern of muscle involvement in smaller patient cohorts, but a large imaging study across the entire spectrum of the dysferlinopathies had not been performed and previous imaging findings were not correlated with functional tests. We present cross-sectional T1-weighted muscle MRI data from 182 patients with genetically confirmed dysferlinopathies. We have analysed the pattern of muscles involved in the disease using hierarchical analysis and presented it as heatmaps. Results of the MRI scans have been correlated with relevant functional tests for each region of the body analysed. In 181 of the 182 patients scanned, we observed muscle pathology on T1-weighted images, with the gastrocnemius medialis and the soleus being the most commonly affected muscles. A similar pattern of involvement was identified in most patients regardless of their clinical presentation. Increased muscle pathology on MRI correlated positively with disease duration and functional impairment. The information generated by this study is of high diagnostic value and important for clinical trial development. We have been able to describe a pattern that can be considered as characteristic of dysferlinopathy. We have defined the natural history of the disease from a radiological point of view. These results enabled the identification of the most relevant regions of interest for quantitative MRI in longitudinal studies, such as clinical trials. NCT01676077. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Breast Cyst Aspiration

MedlinePlus

... TestingRead Article >>Plasma Viral Load TestingInsulin TherapyRead Article >>Insulin Therapy Visit our interactive symptom checker Visit our interactive symptom checker Get Started Related ArticlesPlasma Viral Load TestingRead ... TherapyRead Article >>Drugs, Procedures & DevicesInsulin TherapyThe goal of ...

21 CFR 58.113 - Mixtures of articles with carriers.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Mixtures of articles with carriers. 58.113 Section... GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.113 Mixtures of articles with carriers. (a) For each test or control article that is mixed with a carrier, tests...

21 CFR 58.113 - Mixtures of articles with carriers.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Mixtures of articles with carriers. 58.113 Section... GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.113 Mixtures of articles with carriers. (a) For each test or control article that is mixed with a carrier, tests...

21 CFR 58.113 - Mixtures of articles with carriers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Mixtures of articles with carriers. 58.113 Section... GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.113 Mixtures of articles with carriers. (a) For each test or control article that is mixed with a carrier, tests...

21 CFR 58.113 - Mixtures of articles with carriers.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Mixtures of articles with carriers. 58.113 Section... GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.113 Mixtures of articles with carriers. (a) For each test or control article that is mixed with a carrier, tests...

21 CFR 58.113 - Mixtures of articles with carriers.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Mixtures of articles with carriers. 58.113 Section... GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.113 Mixtures of articles with carriers. (a) For each test or control article that is mixed with a carrier, tests...

Utilization survey of prototype structural test article

NASA Technical Reports Server (NTRS)

Baber, S.; Mcdaniel, H. M.; Berry, M. J.

1974-01-01

A survey was conducted of six aerospace companies and two NASA agencies to determine how prototype structural test articles are used in flight operations. The prototype structures are airframes and similar devices which are used for testing and generally are not flown. The survey indicated the following: (1) prototype test articles are not being discarded after development testing is complete, but are used for other purposes, (2) only two cases of prototypes being refurbished and flown were identified, (3) protective devices and inspection techniques are available to prevent or minimize test article damage, (4) substitute programs from design verification are availabel in lieu of using prototype structural articles, and (5) there is a trend away from dedicated test articles. Four options based on these study results were identified to reduce test and hardware costs without compromising reliability of the flight program.

14 CFR 61.45 - Practical tests: Required aircraft and equipment.

Code of Federal Regulations, 2013 CFR

2013-01-01

... test must have engine power controls and flight controls that are easily reached and operable in a... TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS General § 61...)(2) of this section or when permitted to accomplish the entire flight increment of the practical test...

14 CFR 61.45 - Practical tests: Required aircraft and equipment.

Code of Federal Regulations, 2012 CFR

2012-01-01

... test must have engine power controls and flight controls that are easily reached and operable in a... TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS General § 61...)(2) of this section or when permitted to accomplish the entire flight increment of the practical test...

14 CFR 61.45 - Practical tests: Required aircraft and equipment.

Code of Federal Regulations, 2014 CFR

2014-01-01

... test must have engine power controls and flight controls that are easily reached and operable in a... TRANSPORTATION (CONTINUED) AIRMEN CERTIFICATION: PILOTS, FLIGHT INSTRUCTORS, AND GROUND INSTRUCTORS General § 61...)(2) of this section or when permitted to accomplish the entire flight increment of the practical test...

Looking into the future: Using induced pluripotent stem cells to build two and three dimensional ocular tissue for cell therapy and disease modeling.

PubMed

Song, Min Jae; Bharti, Kapil

2016-05-01

Retinal degenerative diseases are the leading cause of irreversible vision loss in developed countries. In many cases the diseases originate in the homeostatic unit in the back of the eye that contains the retina, retinal pigment epithelium (RPE) and the choriocapillaris. RPE is a central and a critical component of this homeostatic unit, maintaining photoreceptor function and survival on the apical side and choriocapillaris health on the basal side. In diseases like age-related macular degeneration (AMD), it is thought that RPE dysfunctions cause disease-initiating events and as the RPE degenerates photoreceptors begin to die and patients start loosing vision. Patient-specific induced pluripotent stem (iPS) cell-derived RPE provides direct access to a patient's genetics and allow the possibility of identifying the initiating events of RPE-associated degenerative diseases. Furthermore, iPS cell-derived RPE cells are being tested as a potential cell replacement in disease stages with RPE atrophy. In this article we summarize the recent progress in the field of iPS cell-derived RPE "disease modeling" and cell therapies and also discuss the possibilities of developing a model of the entire homeostatic unit to aid in studying disease processes in the future. This article is part of a Special Issue entitled SI: PSC and the brain. Published by Elsevier B.V.

Phylogenetic analyses of the genus Aeromonas based on housekeeping gene sequencing and its influence on systematics.

PubMed

Navarro, Aaron; Martínez-Murcia, Antonio

2018-04-19

The phylogenies derived from housekeeping gene sequence alignments, although mere evolutionary hypotheses, have increased our knowledge about the Aeromonas genetic diversity, providing a robust species delineation framework invaluable for reliable, easy and fast species identification. Previous classifications of Aeromonas, have been fully surpassed by recently developed phylogenetic (natural) classification obtained from the analysis of so-called "molecular chronometers". Despite ribosomal RNAs cannot split all known Aeromonas species, the conserved nature of 16S rRNA offers reliable alignments containing mosaics of sequence signatures which may serve as targets of genus-specific oligonucleotides for subsequent identification/detection tests in samples without culturing. On the contrary, some housekeeping genes coding for proteins show a much better chronometric capacity to discriminate highly related strains. Although both, species and loci, do not all evolve at exactly the same rate, published Aeromonas phylogenies were congruent to each other, indicating that, phylogenetic markers are synchronized and a concatenated multi-gene phylogeny, may be "the mirror" of the entire genomic relationships. Thanks to MLPA approaches, the discovery of new Aeromonas species and strains of rarely isolated species is today more frequent and, consequently, should be extensively promoted for isolate screening and species identification. Although, accumulated data still should be carefully catalogued to inherit a reliable database. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Real-world outcomes of unrestricted direct-acting antiviral treatment for hepatitis C in Australia: The South Australian statewide experience.

PubMed

Haridy, James; Wigg, Alan; Muller, Kate; Ramachandran, Jeyamani; Tilley, Emma; Waddell, Victoria; Gordon, David; Shaw, David; Huynh, Dep; Stewart, Jeffrey; Nelson, Renjy; Warner, Morgyn; Boyd, Mark; Chinnaratha, Mohamed A; Harding, Damian; Ralton, Lucy; Colman, Anton; Liew, Danny; Iyngkaran, Guru; Tse, Edmund

2018-06-11

In March 2016, the Australian government offered unrestricted access to direct-acting antiviral (DAA) therapy for chronic hepatitis C (HCV) to the entire population. This included prescription by any medical practitioner in consultation with specialists until sufficient experience was attained. We sought to determine the outcomes and experience over the first twelve-months for the entire state of South Australia. We performed a prospective, observational study following outcomes of all treatments associated with the state's four main tertiary centres. 1909 subjects initiating DAA therapy were included, representing an estimated 90% of all treatments in the state. Overall, SVR12 was 80.4% in all subjects intended for treatment and 95.7% in those completing treatment and follow-up. 14.2% were lost to follow-up (LTFU) and did not complete SVR12 testing. LTFU was independently associated with community treatment via remote consultation (OR 1.50, 95% CI 1.04-2.18, p=0.03), prison-based treatment (OR 2.02, 95% CI 1.08-3.79, p=0.03) and younger age (OR 0.98, 95% CI 0.97-0.99, p=0.05). Of the 1534 subjects completing treatment and follow-up, decreased likelihood of SVR12 was associated with genotype 2 (OR 0.23,95% CI 0.07-0.74, p=0.01) and genotype 3 (OR 0.23 95% CI 0.12-0.43, p=<0.01). A significant decrease in treatment initiation was observed over the twelve-month period in conjunction with a shift from hospital to community-based treatment. Our findings support the high responses observed in clinical trials, however a significant gap exists in SVR12 in our real-world cohort due to LTFU. A declining treatment initiation rate and shift to community-based treatment highlights the need to explore additional strategies to identify, treat and follow-up remaining patients in order to achieve elimination targets. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Frequency of breast cancer, lung cancer, and tobacco use articles in women's magazines from 1987 to 2003.

PubMed

Tobler, Kyle J; Wilson, Philip K; Napolitano, Peter G

2009-01-01

The objective of this study was to compare the frequency of articles in women's magazines that address breast cancer, lung cancer, and tobacco use from 1987-2003 and to ascertain whether the annual number of articles reflected corresponding cancer mortality rates from breast cancer and lung cancer and the number of female smokers throughout this time period. We reviewed 13 women's magazines published in the United States from 1987-2003 using the search terms breast cancer, lung cancer, smoking, and tobacco. We reviewed the abstracts or entire articles to determine relevance. A total of 1044 articles addressed breast cancer, lung cancer, or tobacco use: 681 articles related to breast cancer, 47 related to lung cancer, and 316 related to tobacco use. The greater number of breast cancer articles compared to lung cancer articles was statistically significant (P value < .0001). The greater number of breast cancer articles compared to lung cancer articles combined with tobacco use articles was also statistically significant (P = .0012). The annual number breast cancer articles compared to the breast cancer mortality rate demonstrated a negative relationship. The annual number of lung cancer articles compared to the lung cancer mortality rate demonstrated no relationship. The annual number of tobacco use articles compared to the annual number of female smokers demonstrated no relationship. Breast cancer was more frequently represented than lung cancer or tobacco use in women's magazines from 1987-2003 despite the increase in lung cancer mortality, a decrease in breast cancer mortality, and an insignificant change in the number of female smokers.

The Evaluation of Hospital Performance in Iran: A Systematic Review Article

PubMed Central

BAHADORI, Mohammadkarim; IZADI, Ahmad Reza; GHARDASHI, Fatemeh; RAVANGARD, Ramin; HOSSEINI, Seyed Mojtaba

2016-01-01

Background: This research aimed to systematically study and outline the methods of hospital performance evaluation used in Iran. Methods: In this systematic review, all Persian and English-language articles published in the Iranian and non-Iranian scientific journals indexed from Sep 2004 to Sep 2014 were studied. For finding the related articles, the researchers searched the Iranian electronic databases, including SID, IranMedex, IranDoc, Magiran, as well as the non-Iranian electronic databases, including Medline, Embase, Scopus, and Google Scholar. For reviewing the selected articles, a data extraction form, developed by the researchers was used. Results: The entire review process led to the selection of 51 articles. The publication of articles on the hospital performance evaluation in Iran has increased considerably in the recent years. Besides, among these 51 articles, 38 articles (74.51%) had been published in Persian language and 13 articles (25.49%) in English language. Eight models were recognized as evaluation model for Iranian hospitals. Totally, in 15 studies, the data envelopment analysis model had been used to evaluate the hospital performance. Conclusion: Using a combination of model to integrate indicators in the hospital evaluation process is inevitable. Therefore, the Ministry of Health and Medical Education should use a set of indicators such as the balanced scorecard in the process of hospital evaluation and accreditation and encourage the hospital managers to use them. PMID:27516991

The Evaluation of Hospital Performance in Iran: A Systematic Review Article.

PubMed

Bahadori, Mohammadkarim; Izadi, Ahmad Reza; Ghardashi, Fatemeh; Ravangard, Ramin; Hosseini, Seyed Mojtaba

2016-07-01

This research aimed to systematically study and outline the methods of hospital performance evaluation used in Iran. In this systematic review, all Persian and English-language articles published in the Iranian and non-Iranian scientific journals indexed from Sep 2004 to Sep 2014 were studied. For finding the related articles, the researchers searched the Iranian electronic databases, including SID, IranMedex, IranDoc, Magiran, as well as the non-Iranian electronic databases, including Medline, Embase, Scopus, and Google Scholar. For reviewing the selected articles, a data extraction form, developed by the researchers was used. The entire review process led to the selection of 51 articles. The publication of articles on the hospital performance evaluation in Iran has increased considerably in the recent years. Besides, among these 51 articles, 38 articles (74.51%) had been published in Persian language and 13 articles (25.49%) in English language. Eight models were recognized as evaluation model for Iranian hospitals. Totally, in 15 studies, the data envelopment analysis model had been used to evaluate the hospital performance. Using a combination of model to integrate indicators in the hospital evaluation process is inevitable. Therefore, the Ministry of Health and Medical Education should use a set of indicators such as the balanced scorecard in the process of hospital evaluation and accreditation and encourage the hospital managers to use them.

Joint and Soft Tissue Injections

MedlinePlus

... TestingRead Article >>Plasma Viral Load TestingInsulin TherapyRead Article >>Insulin Therapy Visit our interactive symptom checker Visit our interactive symptom checker Get Started Related ArticlesPlasma Viral Load TestingRead ... TherapyRead Article >>Drugs, Procedures & DevicesInsulin TherapyThe goal of ...

33 CFR 67.10-20 - Sound signal tests.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Sound signal tests. 67.10-20... signals § 67.10-20 Sound signal tests. (a) Sound signal tests must: (1) Be made by the applicant in the... meters; and (3) Be made in an anechoic chamber large enough to accommodate the entire sound signal, as if...

Students, Parents, and Teachers Say, "Take This Test and Shove It!"

ERIC Educational Resources Information Center

Spritzler, John

2000-01-01

Public school students, parents, and teachers are protesting "high stakes" standardized tests that bar many deserving students from promotion or graduation. A typical high stakes test is a state-mandated 10th-grade test that students must pass to graduate high school. They are called high stakes because a student's entire high school career rides…

Operational Test and Evaluation Manual

DTIC Science & Technology

2011-06-28

Fiscal Office manages all funds received throughout the year for Operations and Maintenance Marine Corps (O&MMC); Research , Development, Test, and... Research , Development, and Acquisition) Assistant Secretary of the Navy ( Research , Development, and Acquisition) (ASN (RDA)) is the DOD’s Component...entire acquisition cycle (SECNAV 2008). This accumulation of data starts with early research and developmental testing and Other tests and

33 CFR 67.10-20 - Sound signal tests.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Sound signal tests. 67.10-20... signals § 67.10-20 Sound signal tests. (a) Sound signal tests must: (1) Be made by the applicant in the... meters; and (3) Be made in an anechoic chamber large enough to accommodate the entire sound signal, as if...

33 CFR 67.10-20 - Sound signal tests.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Sound signal tests. 67.10-20... signals § 67.10-20 Sound signal tests. (a) Sound signal tests must: (1) Be made by the applicant in the... meters; and (3) Be made in an anechoic chamber large enough to accommodate the entire sound signal, as if...

33 CFR 67.10-20 - Sound signal tests.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Sound signal tests. 67.10-20... signals § 67.10-20 Sound signal tests. (a) Sound signal tests must: (1) Be made by the applicant in the... meters; and (3) Be made in an anechoic chamber large enough to accommodate the entire sound signal, as if...

24 CFR 3280.612 - Tests and inspection.

Code of Federal Regulations, 2012 CFR

2012-04-01

... to a pressure test. The test shall be made by subjecting the system to air or water at 100 psi for 15 minutes without loss of pressure. (b) Drainage and vent system and plumbing fixtures. The waste and vent... plugged, the entire system shall be subjected to a 2-inch (manometer) water column air pressure test. If...

24 CFR 3280.612 - Tests and inspection.

Code of Federal Regulations, 2014 CFR

2014-04-01

... to a pressure test. The test shall be made by subjecting the system to air or water at 100 psi for 15 minutes without loss of pressure. (b) Drainage and vent system and plumbing fixtures. The waste and vent... plugged, the entire system shall be subjected to a 2-inch (manometer) water column air pressure test. If...

24 CFR 3280.612 - Tests and inspection.

Code of Federal Regulations, 2013 CFR

2013-04-01

... to a pressure test. The test shall be made by subjecting the system to air or water at 100 psi for 15 minutes without loss of pressure. (b) Drainage and vent system and plumbing fixtures. The waste and vent... plugged, the entire system shall be subjected to a 2-inch (manometer) water column air pressure test. If...

24 CFR 3280.612 - Tests and inspection.

Code of Federal Regulations, 2011 CFR

2011-04-01

... to a pressure test. The test shall be made by subjecting the system to air or water at 100 psi for 15 minutes without loss of pressure. (b) Drainage and vent system and plumbing fixtures. The waste and vent... plugged, the entire system shall be subjected to a 2-inch (manometer) water column air pressure test. If...

Contextual memory and skill transfer in category search.

PubMed

Kole, James A; Healy, Alice F; Fierman, Deanna M; Bourne, Lyle E

2010-01-01

In three experiments, we examined transfer and contextual memory in a category search task. Each experiment included two phases (training and test), during which participants searched through category and exemplar menus for targets. In Experiment 1, the targets were from one of two domains during training (grocery store or department store); the domain was either the same or changed at test. Also, the categories were organized in one of two ways (alphabetically or semantically); the organization either remained the same or changed at test. In Experiments 2 and 3, domain and organization were held constant; however, categories or exemplars were the same, partially replaced, or entirely replaced across phases in order to simulate the dynamic nature of category search in everyday situations. Transfer occurred at test when the category organization or domain was maintained and when the categories or exemplars matched (partially or entirely) those at training. These results demonstrate that transfer is facilitated by overlap in training and testing contexts.

21 CFR 58.47 - Facilities for handling test and control articles.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Facilities for handling test and control articles... for handling test and control articles. (a) As necessary to prevent contamination or mixups, there shall be separate areas for: (1) Receipt and storage of the test and control articles. (2) Mixing of the...

21 CFR 58.47 - Facilities for handling test and control articles.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Facilities for handling test and control articles... for handling test and control articles. (a) As necessary to prevent contamination or mixups, there shall be separate areas for: (1) Receipt and storage of the test and control articles. (2) Mixing of the...

21 CFR 58.47 - Facilities for handling test and control articles.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Facilities for handling test and control articles... for handling test and control articles. (a) As necessary to prevent contamination or mixups, there shall be separate areas for: (1) Receipt and storage of the test and control articles. (2) Mixing of the...

21 CFR 58.47 - Facilities for handling test and control articles.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Facilities for handling test and control articles... for handling test and control articles. (a) As necessary to prevent contamination or mixups, there shall be separate areas for: (1) Receipt and storage of the test and control articles. (2) Mixing of the...

Nursing Care of Patients Undergoing Chemotherapy Desensitization: Part I.

PubMed

Jakel, Patricia; Carsten, Cynthia; Braskett, Melinda; Carino, Arvie

2016-02-01

Hypersensitivity reactions to chemotherapeutic agents can cause the discontinuation of first-line therapies. Chemotherapy desensitization is a safe, but labor-intensive, process to administer these important medications. A desensitization protocol can enable a patient to receive the entire target dose of a medication, even if the patient has a history of severe infusion reactions. In this article, the authors explain the pathophysiology of hypersensitivity reactions and describe the recent development of desensitization protocols in oncology. In part II of this article, which will appear in the April 2016 issue of the Clinical Journal of Oncology Nursing, the authors will give a detailed account of how a desensitization protocol is performed at an academic medical center.
.

The "cradle of glass": incubators for infants in late nineteenth-century France.

PubMed

Greene, Gina

2010-01-01

This article examines the development of the incubator for premature infants in fin-de-siècle France. During a period of widespread anxiety in France regarding infant mortality and its implications for population growth, physicians in Paris developed and widely promoted the lifesaving technology. This article explores the ways in which the incubator reflected new scientific and symbolic approaches to creating hygienic spaces as well as how it reflected new scientific and symbolic approaches to the traditionally feminine project of infant care. By creating such an isolating and protective milieu around premature infants—an entirely new population of patients—the incubator, I argue, heralded a renegotiation of the boundary between motherhood and medical authority.

Methods and Algorithms for Computer-aided Engineering of Die Tooling of Compressor Blades from Titanium Alloy

NASA Astrophysics Data System (ADS)

Khaimovich, A. I.; Khaimovich, I. N.

2018-01-01

The articles provides the calculation algorithms for blank design and die forming fitting to produce the compressor blades for aircraft engines. The design system proposed in the article allows generating drafts of trimming and reducing dies automatically, leading to significant reduction of work preparation time. The detailed analysis of the blade structural elements features was carried out, the taken limitations and technological solutions allowed to form generalized algorithms of forming parting stamp face over the entire circuit of the engraving for different configurations of die forgings. The author worked out the algorithms and programs to calculate three dimensional point locations describing the configuration of die cavity.

The crowbar chronicles and other tales

USGS Publications Warehouse

Hough, Susan E.

2009-01-01

The analysis of historical earthquakes often relies heavily on archival accounts describing the effects of shaking on structures and people. Newspaper articles are among the most common, useful, and easily found sources of information. Dramatic earthquake effects are almost certain to have made the news during historic times; the challenge for modern seismologists is not to be overly swayed by articles that focus on the most dramatic rather than the representative effects in a region. At the other end of the spectrum, rarely does a historical newspaper explicitly note that an earthquake was not felt in a certain area: it is not news when nothing happens. When earthquake effects are subtle, the vexing question is often, did they go unreported entirely?

Reading, the Library, and the Elderly: A Singapore Case Study

ERIC Educational Resources Information Center

Luyt, Brendan; Ann, Ho Swee

2011-01-01

Singapore is now one of the fastest aging societies in the world. By 2030 those over 65 years old are expected to number 1.41m strong, 26.8 percent of the country's entire population. Given these numbers, it is not surprising that aging is a key concern in Singapore. This article reports on a qualitative study of 32 individuals over the age of 55…

"MSN Was the next Big Thing after Beanie Babies": Children's Virtual Experiences as an Interface to Their Identities and Their Everyday Lives

ERIC Educational Resources Information Center

Thomas, Angela

2006-01-01

In this article the author explores the seamlessness between children's online and offline worlds. For children, there is no dichotomy of online and offline, or virtual and real; the digital is so much intertwined into their lives and psyche that the one is entirely enmeshed with the other. Despite early research pointing to the differences that…

International Aviation (Selected Articles).

DTIC Science & Technology

1982-07-15

large axial aerodynamic load for a long time, operating life greatly decreased. For this reason, most adopted the following measures: 1) Readjusted...little. This can cause the forward axial force of the entire rotor to increase (this affects the load on the thrust bearing). For this reason, it is...generator. When the prototype is a turbofan , the following method can be adopted to obtain a gas generator: 1. Eliminate the fan and low pressure

Applications for alliform carbon

DOEpatents

Gogotsi, Yury; Mochalin, Vadym; McDonough, IV, John Kenneth; Simon, Patrice; Taberna, Pierre Louis

2017-02-21

This invention relates to novel applications for alliform carbon, useful in conductors and energy storage devices, including electrical double layer capacitor devices and articles incorporating such conductors and devices. Said alliform carbon particles are in the range of 2 to about 20 percent by weight, relative to the weight of the entire electrode. Said novel applications include supercapacitors and associated electrode devices, batteries, bandages and wound healing, and thin-film devices, including display devices.

"But We're in a Court of Law. We're Not in a Legislature.": The Promise and Pitfalls of Educational Policy Reform through the Judicial Branch

ERIC Educational Resources Information Center

Mayrowetz, David; Lapham, John

2008-01-01

When courts engage in educational policymaking through what is called "public law litigation," they set foot in unsettled territory. Framing the authors' work in legal studies literature, this article relays how one court engaged in a sweeping reform of special education in Chicago and teacher certification in the entire state of…

Toward a virtual platform for materials processing

NASA Astrophysics Data System (ADS)

Schmitz, G. J.; Prahl, U.

2009-05-01

Any production is based on materials eventually becoming components of a final product. Material properties being determined by the microstructure of the material thus are of utmost importance both for productivity and reliability of processing during production and for application and reliability of the product components. A sound prediction of materials properties therefore is highly important. Such a prediction requires tracking of microstructure and properties evolution along the entire component life cycle starting from a homogeneous, isotropic and stress-free melt and eventually ending in failure under operational load. This article will outline ongoing activities at the RWTH Aachen University aiming at establishing a virtual platform for materials processing comprising a virtual, integrative numerical description of processes and of the microstructure evolution along the entire production chain and even extending further toward microstructure and properties evolution under operational conditions.

Semi-Automated Full Battery.

ERIC Educational Resources Information Center

Vincent, Ken R.

1980-01-01

Presents the format for the development of interpretive statements covering an entire test battery content on both objective tests and projective instruments. This procedure, the semiautomated full battery, can lessen significantly the time and much of the repetition entailed in psychological report writing. (Author)

The Danish test battery for auditory processing disorder evaluated with patient and control data.

PubMed

Raben Pedersen, Ellen

2018-06-10

This study evaluates the Danish test battery for auditory processing disorder (APD). The battery consists of four behavioural tests, two speech and two non-speech stimuli tests. The evaluation includes determination of: (1) new cut-off values (pass-fail criteria), (2) the sensitivity and the specificity of the entire test battery and (3) the failure rate of different test combinations. For each test in the battery, cut-off values were determined using the weighted Youden index. Applying the newly derived cut-off values, the distribution of failing specific test combinations was determined. A group of 112 children diagnosed with APD (57 boys, 55 girls, aged 6-16 years) and a control group containing 158 children without auditory problems (75 boys, 83 girls, aged 6-16 years). Cut-off values for different weights of the sensitivity and the specificity have been determined. Using the criterion that at least two tests have to be failed for APD to be suspected, the sensitivity and the specificity of the entire test battery were 95.3% and 91.6%, respectively. Some test combinations were found to have higher failure rates than others. Due to the high sensitivity and specificity the test battery has good predictive value in APD assessment.

Educational testing validity and reliability in pharmacy and medical education literature.

PubMed

Hoover, Matthew J; Jung, Rose; Jacobs, David M; Peeters, Michael J

2013-12-16

To evaluate and compare the reliability and validity of educational testing reported in pharmacy education journals to medical education literature. Descriptions of validity evidence sources (content, construct, criterion, and reliability) were extracted from articles that reported educational testing of learners' knowledge, skills, and/or abilities. Using educational testing, the findings of 108 pharmacy education articles were compared to the findings of 198 medical education articles. For pharmacy educational testing, 14 articles (13%) reported more than 1 validity evidence source while 83 articles (77%) reported 1 validity evidence source and 11 articles (10%) did not have evidence. Among validity evidence sources, content validity was reported most frequently. Compared with pharmacy education literature, more medical education articles reported both validity and reliability (59%; p<0.001). While there were more scholarship of teaching and learning (SoTL) articles in pharmacy education compared to medical education, validity, and reliability reporting were limited in the pharmacy education literature.

Superconducting composite with multilayer patterns and multiple buffer layers

DOEpatents

Wu, X.D.; Muenchausen, R.E.

1993-10-12

An article of manufacture is described including a substrate, a patterned interlayer of a material selected from the group consisting of magnesium oxide, barium-titanium oxide or barium-zirconium oxide, the patterned interlayer material overcoated with a secondary interlayer material of yttria-stabilized zirconia or magnesium-aluminum oxide, upon the surface of the substrate whereby an intermediate article with an exposed surface of both the overcoated patterned interlayer and the substrate is formed, a coating of a buffer layer selected from the group consisting of cerium oxide, yttrium oxide, curium oxide, dysprosium oxide, erbium oxide, europium oxide, iron oxide, gadolinium oxide, holmium oxide, indium oxide, lanthanum oxide, manganese oxide, lutetium oxide, neodymium oxide, praseodymium oxide, plutonium oxide, samarium oxide, terbium oxide, thallium oxide, thulium oxide, yttrium oxide and ytterbium oxide over the entire exposed surface of the intermediate article, and, a ceramic superconductor. 5 figures.

The impact of various distance between axes of worm gear on torque value. Worm gear test stand

NASA Astrophysics Data System (ADS)

Sobek, M.; Baier, A.; Grabowski, Ł.

2017-08-01

Transferring both rotational and translational movements in systems used in the automotive industry is a very important and complex issue. In addition, the situation becomes much more difficult and complicated when the design of the transition system requires a high precision of operation as well as a well definite and long operating life. Such requirements are imposed on all components of today’s motor vehicles. However, particular attention is paid to the elements that directly or indirectly affect the safety of persons traveling in the vehicle. Such components are undoubtedly components included as parts of the steering system of the vehicle. Power steering systems have been present in motor vehicles for more than a century. They go through continuous metamorphosis and they are getting better and better. Current power steering systems are based on an electric motor and some kind of transmission. Depending on the position of the drive relative to the steering column, different configurations of the transmission are used. This article will cover issues related to tests of power steering gearing using a worm drive. The worm drive is a very specific example of a propulsion system that uses twisted axles. Normally, in this type of transition you can find two gear units with the axis mounted with a 90° angle between. The components of the worm drive are a worm and a worm gear, also called a worm wheel. In terms of the geometrical form, the worm resembles a helical spur gear. The shape of the worm is similar to the shape of a screw with a trapezoidal thread. A correct matching of these two components ensures proper operation of the entire transmission. Incorrect positioning of the components in relation to each other can significantly reduce the lifetime of the drive unit, and also lead to abnormal work, eg by raising the noise level. This article describes a test method of finding the appropriate distance between the axles of both worm drive units by testing the torque change during gear operation.

Lens testing using total internal reflection holography

DOEpatents

Hildebrand, Bernard P.

1976-12-14

Accurate, rapid and inexpensive testing and inspecting of lens surfaces tugh holographic means requiring no beamsplitters, mirrors or overpower optics, and wherein a hologram formed in accordance with one aspect of the invention contains the entire interferometer and serves as both a master and illuminating source for both concave and convex surfaces to be so tested.

Accelerated Desensitization with Adaptive Attitudes and Test Gains with 5th Graders

ERIC Educational Resources Information Center

Miller, Melanie; Morton, Jerome; Driscoll, Richard; Davis, Kai A.

2006-01-01

The study evaluates an easily-administered test-anxiety reduction program. An entire fifth grade was screened, and 36 students identified as test-anxious were randomly assigned to an Intervention or a non-participant Control group. The intervention was an accelerated desensitization and adaptive attitudes (ADAA) treatment which involved…

Space Shuttle Project

NASA Image and Video Library

1978-04-21

This is an interior ground level view of the Shuttle Orbiter Enterprise being lowered for mating to External Tank (ET) inside Marshall Space Flight Center's Dynamic Test Stand for Mated Vertical Ground Vibration tests (MVGVT). The tests marked the first time ever that the entire shuttle complement (including Orbiter, external tank, and solid rocket boosters) were mated vertically.

A Guide to Computer Adaptive Testing Systems

ERIC Educational Resources Information Center

Davey, Tim

2011-01-01

Some brand names are used generically to describe an entire class of products that perform the same function. "Kleenex," "Xerox," "Thermos," and "Band-Aid" are good examples. The term "computerized adaptive testing" (CAT) is similar in that it is often applied uniformly across a diverse family of testing methods. Although the various members of…

Spurring enrollment in Medicare savings programs through a substitute for the asset test focused on investment income.

PubMed

Dorn, Stan; Shang, Baoping

2012-02-01

Fewer than one-third of eligible Medicare beneficiaries enroll in Medicare savings programs, which pay premiums and, in some cases, eliminate out-of-pocket cost sharing for poor and near-poor enrollees. Many beneficiaries don't participate in savings programs because they must complete a cumbersome application process, including a burdensome asset test. We demonstrate that a streamlined alternative to the asset test-allowing seniors to qualify for Medicare savings programs by providing evidence of limited assets or showing a lack of investment income-would permit 78 percent of currently eligible seniors to bypass the asset test entirely. This simplified approach would increase the number of beneficiaries who qualify for Medicare savings programs from the current 3.6 million seniors to 4.6 million. Such an alternative would keep benefits targeted to people with low assets, eliminate costly administrative expenses and obstacles to enrollment associated with the asset test, and avoid the much larger influx of seniors that would occur if the asset test were eliminated entirely.

The Potential, Pitfalls and Promise of Computerized Testing

ERIC Educational Resources Information Center

McHenry, Bill; Griffith, Leonard; McHenry, Jim

2004-01-01

Imagine administering an online standardized test to an entire class of 11th-grade students when, halfway through the exam, the server holding the test hits a snag and throws everyone offline. Imagine another scenario in which an elementary school has very few computers so teachers must bus their students to the local high school for a timed test.…

STELAR: An experiment in the electronic distribution of astronomical literature

NASA Technical Reports Server (NTRS)

Warnock, A.; Vansteenburg, M. E.; Brotzman, L. E.; Gass, J.; Kovalsky, D.

1992-01-01

STELAR (Study of Electronic Literature for Astronomical Research) is a Goddard-based project designed to test methods of delivering technical literature in machine readable form. To that end, we have scanned a five year span of the ApJ, ApJ Supp, AJ and PASP, and have obtained abstracts for eight leading academic journals from NASA/STI CASI, which also makes these abstracts available through the NASA RECON system. We have also obtained machine readable versions of some journal volumes from the publishers, although in many instances, the final typeset versions are no longer available. The fundamental data object for the STELAR database is the article, a collection of items associated with a scientific paper - abstract, scanned pages (in a variety of formats), figures, OCR extractions, forward and backward references, errata and versions of the paper in various formats (e.g., TEX, SGML, PostScript, DVI). Articles are uniquely referenced in the database by journal name, volume number and page number. The selection and delivery of articles is accomplished through the WAIS (Wide Area Information Server) client/server models requiring only an Internet connection. Modest modifications to the server code have made it capable of delivering the multiple data types required by STELAR. WAIS is a platform independent and fully open multi-disciplinary delivery system, originally developed by Thinking Machines Corp. and made available free of charge. It is based on the ISO Z39.50 standard communications protocol. WAIS servers run under both UNIX and VMS. WAIS clients run on a wide variety of machines, from UNIX-based Xwindows systems to MS-DOS and macintosh microcomputers. The WAIS system includes full-test indexing and searching of documents, network interface and easy access to a variety of document viewers. ASCII versions of the CASI abstracts have been formatted for display and the full test of the abstracts has been indexed. The entire WAIS database of abstracts is now available for use by the astronomical community. Enhancements of the search and retrieval system are under investigation to include specialized searches (by reference, author or keyword, as opposed to full test searches), improved handling of word stems, improvements in relevancy criteria and other retrieval techniques, such as factor spaces. The STELAR project has been assisted by the full cooperation of the AAS, the ASP, the publishers of the academic journals, librarians from GSFC, NRAO and STScI, the Library of Congress, and the University of North Carolina at Chapel Hill.

48 CFR 52.209-3 - First Article Approval-Contractor Testing.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false First Article Approval... Clauses 52.209-3 First Article Approval—Contractor Testing. As prescribed in 9.308-1 (a) and (b), insert the following clause: First Article Approval—Contractor Testing (SEP 1989) [Contracting Officer shall...

48 CFR 52.209-4 - First Article Approval-Government Testing.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false First Article Approval... Clauses 52.209-4 First Article Approval—Government Testing. As prescribed in 9.308-2 (a) and (b), insert the following clause: First Article Approval—Government Testing (SEP 1989) [Contracting Officer shall...

48 CFR 52.209-4 - First Article Approval-Government Testing.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false First Article Approval... Clauses 52.209-4 First Article Approval—Government Testing. As prescribed in 9.308-2 (a) and (b), insert the following clause: First Article Approval—Government Testing (SEP 1989) [Contracting Officer shall...

48 CFR 52.209-4 - First Article Approval-Government Testing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false First Article Approval... Clauses 52.209-4 First Article Approval—Government Testing. As prescribed in 9.308-2 (a) and (b), insert the following clause: First Article Approval—Government Testing (SEP 1989) [Contracting Officer shall...

48 CFR 52.209-4 - First Article Approval-Government Testing.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false First Article Approval... Clauses 52.209-4 First Article Approval—Government Testing. As prescribed in 9.308-2 (a) and (b), insert the following clause: First Article Approval—Government Testing (SEP 1989) [Contracting Officer shall...

48 CFR 52.209-3 - First Article Approval-Contractor Testing.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false First Article Approval... Clauses 52.209-3 First Article Approval—Contractor Testing. As prescribed in 9.308-1 (a) and (b), insert the following clause: First Article Approval—Contractor Testing (SEP 1989) [Contracting Officer shall...

48 CFR 52.209-3 - First Article Approval-Contractor Testing.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false First Article Approval... Clauses 52.209-3 First Article Approval—Contractor Testing. As prescribed in 9.308-1 (a) and (b), insert the following clause: First Article Approval—Contractor Testing (SEP 1989) [Contracting Officer shall...

48 CFR 52.209-4 - First Article Approval-Government Testing.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false First Article Approval... Clauses 52.209-4 First Article Approval—Government Testing. As prescribed in 9.308-2 (a) and (b), insert the following clause: First Article Approval—Government Testing (SEP 1989) [Contracting Officer shall...

48 CFR 52.209-3 - First Article Approval-Contractor Testing.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false First Article Approval... Clauses 52.209-3 First Article Approval—Contractor Testing. As prescribed in 9.308-1 (a) and (b), insert the following clause: First Article Approval—Contractor Testing (SEP 1989) [Contracting Officer shall...

48 CFR 52.209-3 - First Article Approval-Contractor Testing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false First Article Approval... Clauses 52.209-3 First Article Approval—Contractor Testing. As prescribed in 9.308-1 (a) and (b), insert the following clause: First Article Approval—Contractor Testing (SEP 1989) [Contracting Officer shall...

Nonclinical dose formulation analysis method validation and sample analysis.

PubMed

Whitmire, Monica Lee; Bryan, Peter; Henry, Teresa R; Holbrook, John; Lehmann, Paul; Mollitor, Thomas; Ohorodnik, Susan; Reed, David; Wietgrefe, Holly D

2010-12-01

Nonclinical dose formulation analysis methods are used to confirm test article concentration and homogeneity in formulations and determine formulation stability in support of regulated nonclinical studies. There is currently no regulatory guidance for nonclinical dose formulation analysis method validation or sample analysis. Regulatory guidance for the validation of analytical procedures has been developed for drug product/formulation testing; however, verification of the formulation concentrations falls under the framework of GLP regulations (not GMP). The only current related regulatory guidance is the bioanalytical guidance for method validation. The fundamental parameters for bioanalysis and formulation analysis validations that overlap include: recovery, accuracy, precision, specificity, selectivity, carryover, sensitivity, and stability. Divergence in bioanalytical and drug product validations typically center around the acceptance criteria used. As the dose formulation samples are not true "unknowns", the concept of quality control samples that cover the entire range of the standard curve serving as the indication for the confidence in the data generated from the "unknown" study samples may not always be necessary. Also, the standard bioanalytical acceptance criteria may not be directly applicable, especially when the determined concentration does not match the target concentration. This paper attempts to reconcile the different practices being performed in the community and to provide recommendations of best practices and proposed acceptance criteria for nonclinical dose formulation method validation and sample analysis.

Considerations for the nonclinical safety evaluation of antibody drug conjugates for oncology.

PubMed

Roberts, Stanley A; Andrews, Paul A; Blanset, Diann; Flagella, Kelly M; Gorovits, Boris; Lynch, Carmel M; Martin, Pauline L; Kramer-Stickland, Kimberly; Thibault, Stephane; Warner, Garvin

2013-12-01

Antibody drug conjugates (ADCs) include monoclonal antibodies that are linked to cytotoxic small molecules. A number of these agents are currently being developed as anti-cancer agents designed to improve the therapeutic index of the cytotoxin (i.e., cytotoxic small molecule or cytotoxic agent) by specifically delivering it to tumor cells. This paper presents primary considerations for the nonclinical safety evaluation of ADCs and includes strategies for the evaluation of the entire ADC or the various individual components (i.e., antibody, linker or the cytotoxin). Considerations are presented on how to design a nonclinical safety assessment program to identify the on- and off-target toxicities to enable first-in-human (FIH) studies. Specific discussions are also included that provide details as to the need and how to conduct the studies for evaluating ADCs in genetic toxicology, tissue cross-reactivity, safety pharmacology, carcinogenicity, developmental and reproductive toxicology, biotransformation, toxicokinetic monitoring, bioanalytical assays, immunogenicity testing, test article stability and the selection of the FIH dose. Given the complexity of these molecules and our evolving understanding of their properties, there is no single all-encompassing nonclinical strategy. Instead, each ADC should be evaluated on a case-by-case scientifically-based approach that is consistent with ICH and animal research guidelines. Copyright © 2013 Elsevier Inc. All rights reserved.

Link monitor and control operator assistant: A prototype demonstrating semiautomated monitor and control

NASA Technical Reports Server (NTRS)

Lee, L. F.; Cooper, L. P.

1993-01-01

This article describes the approach, results, and lessons learned from an applied research project demonstrating how artificial intelligence (AI) technology can be used to improve Deep Space Network operations. Configuring antenna and associated equipment necessary to support a communications link is a time-consuming process. The time spent configuring the equipment is essentially overhead and results in reduced time for actual mission support operations. The NASA Office of Space Communications (Code O) and the NASA Office of Advanced Concepts and Technology (Code C) jointly funded an applied research project to investigate technologies which can be used to reduce configuration time. This resulted in the development and application of AI-based automated operations technology in a prototype system, the Link Monitor and Control Operator Assistant (LMC OA). The LMC OA was tested over the course of three months in a parallel experimental mode on very long baseline interferometry (VLBI) operations at the Goldstone Deep Space Communications Center. The tests demonstrated a 44 percent reduction in pre-calibration time for a VLBI pass on the 70-m antenna. Currently, this technology is being developed further under Research and Technology Operating Plan (RTOP)-72 to demonstrate the applicability of the technology to operations in the entire Deep Space Network.

Intervention for individuals with fetal alcohol spectrum disorders: treatment approaches and case management.

PubMed

Paley, Blair; O'Connor, Mary J

2009-01-01

Exposure to alcohol in utero is considered to be the leading cause of developmental disabilities of known etiology. The most severe consequence of such exposure, fetal alcohol syndrome (FAS), is characterized by a distinct constellation of characteristic facial anomalies, growth retardation, and central nervous system (CNS) dysfunction. Some individuals with prenatal alcohol exposure (PAE) do not meet the full criteria for FAS, but instead are diagnosed with partial FAS, alcohol related neurodevelopmental disorder (ARND), or alcohol related birth defects (ARBD). The entire continuum of effects from PAE is increasingly being referred to under the umbrella term of fetal alcohol spectrum disorders (FASDs). An extensive body of research has documented major cognitive, behavioral, adaptive, social, and emotional impairments among individuals with FASDs. Although FAS was identified in the U.S. over 35 years ago, the development, evaluation, and dissemination of evidence-based interventions for individuals with FASDs have lagged behind significantly. Encouragingly, however, in recent years there has been a marked increase in efforts to design and test interventions to remediate the impairments associated with prenatal alcohol exposure. This article will review treatment needs and considerations for individuals with FASDs and their families, current empirically tested treatment approaches, case management issues, and suggestions for future directions in research on the treatment of FASDs. (c) 2009 Wiley-Liss, Inc.

Dual-axis resonance testing of wind turbine blades

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hughes, Scott; Musial, Walter; White, Darris

An apparatus (100) for fatigue testing test articles (104) including wind turbine blades. The apparatus (100) includes a test stand (110) that rigidly supports an end (106) of the test article (104). An actuator assembly (120) is attached to the test article (104) and is adapted for substantially concurrently imparting first and second forcing functions in first and second directions on the test article (104), with the first and second directions being perpendicular to a longitudinal axis. A controller (130) transmits first and second sets of displacement signals (160, 164) to the actuator assembly (120) at two resonant frequencies ofmore » the test system (104). The displacement signals (160, 164) initiate the actuator assembly (120) to impart the forcing loads to concurrently oscillate the test article (104) in the first and second directions. With turbine blades, the blades (104) are resonant tested concurrently for fatigue in the flapwise and edgewise directions.« less

Finite Element Analysis and Test Results Comparison for the Hybrid Wing Body Center Section Test Article

NASA Technical Reports Server (NTRS)

Przekop, Adam; Jegley, Dawn C.; Rouse, Marshall; Lovejoy, Andrew E.

2016-01-01

This report documents the comparison of test measurements and predictive finite element analysis results for a hybrid wing body center section test article. The testing and analysis efforts were part of the Airframe Technology subproject within the NASA Environmentally Responsible Aviation project. Test results include full field displacement measurements obtained from digital image correlation systems and discrete strain measurements obtained using both unidirectional and rosette resistive gauges. Most significant results are presented for the critical five load cases exercised during the test. Final test to failure after inflicting severe damage to the test article is also documented. Overall, good comparison between predicted and actual behavior of the test article is found.

7 CFR 983.53 - Testing of minimal quantities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE PISTACHIOS GROWN IN CALIFORNIA... her entire inventory of hulled and dried pistachios for the aflatoxin certification before further... regarding the testing of minimal quantities of pistachios for quality. [74 FR 56540, Nov. 2, 2009] ...

Pursuing the Qualities of a "Good" Test

ERIC Educational Resources Information Center

Coniam, David

2014-01-01

This article examines the issue of the quality of teacher-produced tests, limiting itself in the current context to objective, multiple-choice tests. The article investigates a short, two-part 20-item English language test. After a brief overview of the key test qualities of reliability and validity, the article examines the two subtests in terms…

Structural Benchmark Creep Testing for Microcast MarM-247 Advanced Stirling Convertor E2 Heater Head Test Article SN18

NASA Technical Reports Server (NTRS)

Krause, David L.; Brewer, Ethan J.; Pawlik, Ralph

2013-01-01

This report provides test methodology details and qualitative results for the first structural benchmark creep test of an Advanced Stirling Convertor (ASC) heater head of ASC-E2 design heritage. The test article was recovered from a flight-like Microcast MarM-247 heater head specimen previously used in helium permeability testing. The test article was utilized for benchmark creep test rig preparation, wall thickness and diametral laser scan hardware metrological developments, and induction heater custom coil experiments. In addition, a benchmark creep test was performed, terminated after one week when through-thickness cracks propagated at thermocouple weld locations. Following this, it was used to develop a unique temperature measurement methodology using contact thermocouples, thereby enabling future benchmark testing to be performed without the use of conventional welded thermocouples, proven problematic for the alloy. This report includes an overview of heater head structural benchmark creep testing, the origin of this particular test article, test configuration developments accomplished using the test article, creep predictions for its benchmark creep test, qualitative structural benchmark creep test results, and a short summary.

Anomalous Thrust Production from an RF Test Device Measured on a Low-Thrust Torsion Pendulum

NASA Technical Reports Server (NTRS)

Brady, David; White, Harold G.; March, Paul; Lawrence, James T.; Davies, Frank J.

2014-01-01

This paper describes the eight-day August 2013 test campaign designed to investigate and demonstrate viability of using classical magnetoplasmadynamics to obtain a propulsive momentum transfer via the quantum vacuum virtual plasma. This paper will not address the physics of the quantum vacuum plasma thruster, but instead will describe the test integration, test operations, and the results obtained from the test campaign. Approximately 30-50 micro-Newtons of thrust were recorded from an electric propulsion test article consisting primarily of a radio frequency (RF) resonant cavity excited at approximately 935 megahertz. Testing was performed on a low-thrust torsion pendulum that is capable of detecting force at a single-digit micronewton level, within a stainless steel vacuum chamber with the door closed but at ambient atmospheric pressure. Several different test configurations were used, including two different test articles as well as a reversal of the test article orientation. In addition, the test article was replaced by an RF load to verify that the force was not being generated by effects not associated with the test article. The two test articles were designed by Cannae LLC of Doylestown, Pennsylvania. The torsion pendulum was designed, built, and operated by Eagleworks Laboratories at the NASA Johnson Space Center of Houston, Texas. Approximately six days of test integration were required, followed by two days of test operations, during which, technical issues were discovered and resolved. Integration of the two test articles and their supporting equipment was performed in an iterative fashion between the test bench and the vacuum chamber. In other words, the test article was tested on the bench, then moved to the chamber, then moved back as needed to resolve issues. Manual frequency control was required throughout the test. Thrust was observed on both test articles, even though one of the test articles was designed with the expectation that it would not produce thrust. Specifically, one test article contained internal physical modifications that were designed to produce thrust, while the other did not (with the latter being referred to as the "null" test article). Test data gathered includes torsion pendulum displacement measurements which are used to calculate generated force, still imagery in the visible spectrum to document the physical configuration, still imagery in the infrared spectrum to characterize the thermal environment, and video imagery. Post-test data includes static and animated graphics produced during RF resonant cavity characterization using the COMSOL Multiphysics® software application. Excerpts from all of the above are included and discussed in this paper. Lessons learned from test integration and operations include identification of the need to replace manual control of the resonant cavity target frequency with an automated frequency control capability. Future test plans include the development of an automatic frequency control circuit. Test results indicate that the RF resonant cavity thruster design, which is unique as an electric propulsion device, is producing a force that is not attributable to any classical electromagnetic phenomenon and therefore is potentially demonstrating an interaction with the quantum vacuum virtual plasma. Future test plans include independent verification and validation at other test facilities.

Handbook for Testing in Navy Schools

DTIC Science & Technology

1982-10-01

an entire test or for groups of related objectives within a test. Remediation in this situation is only given to students who do not achieve the test...is specified in the objective(s). -5- In summary, for all training tasks and related knowledge information, tests should require achievement of the...associated with each .... STEP 2b: CATEGORIES. Categories refer to groups of similar objects, events, or ideas. They are similar, or are grouped

Xenon monitoring and the Comprehensive Nuclear-Test-Ban Treaty

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bowyer, Theodore W.

How do you monitor (verify) a CTBT? It is a difficult challenge to monitor the entire world for nuclear tests, regardless of size. Nuclear tests 'normally' occur underground, above ground or underwater. Setting aside very small tests (let's limit our thinking to 1 kiloton or more), nuclear tests shake the ground, emit large amounts of radioactivity, and make loud noises if in the atmosphere (or hydroacoustic waves if underwater)

The new Section 23 of DO160C/ED14C lightning testing of externally mounted electrical equipment

NASA Astrophysics Data System (ADS)

Burrows, B. J. C.

1991-08-01

The new Section 23 is introduced which has only very recently been fully approved by the RTCA for incorporation into the first revision of DO160C/ED14C. Full threat lightning direct effects testing of equipment is entirely new to DO160, the only existing lightning testing is transient testing for LRU's (Line Replaceable Units) by pin or cable bundle injection methods, for equipment entirely contained within the airframe and assumed to be unaffected by direct effects. This testing required transients of very low amplitude compared with lightning itself, whereas the tests now to be described involve full threat lightning testing, that is using the previously established severe parameters of lightning appropriate to the Zone, such as 200 kA for Zone 1A as in AC20-136. Direct effects (i.e., damage) testing involves normally the lightning current arc attaching to the object under test (or very near to it) so submitting it to full potential for the electric, mechanical, thermal and shock damage which is caused by high current arcing. Since equipment for any part of the airframe require qualification, tests to demonstrate safety of equipment in fuel vapor regions of the airframe are also included.

How Things Get Heavy: The Nature of Mass

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lincoln, Don

Here, physics can be a weighty subject, full of substance and gravitas. It is therefore perhaps entirely reasonable that a central topic of the discipline is mass. But what is mass, really? What is the origin and nature of this most essential feature of the world around us? And are there any surprises to be had as we dig deeper into that question? In this article, I hope to surprise every reader at least once.

How Things Get Heavy: The Nature of Mass

DOE PAGES

Lincoln, Don

2017-10-01

Here, physics can be a weighty subject, full of substance and gravitas. It is therefore perhaps entirely reasonable that a central topic of the discipline is mass. But what is mass, really? What is the origin and nature of this most essential feature of the world around us? And are there any surprises to be had as we dig deeper into that question? In this article, I hope to surprise every reader at least once.

Developing a Supply Chain Management Certification for the Department of Defense

DTIC Science & Technology

2007-12-01

Supply Chain Management, the 77 M. Eric Johnson and David Pyke, “A Framework for Teaching Supply Chain Management,” Production and Operations...Review Web Site (October 5, 2006), http://www.scmr.com/article/CA6378393.html?text=rankings (accessed May 10, 2007). 86 M. Eric Johnson and David...2006). 103 M. Eric Johnson and David Pyke. (2000). 34 When an individual completes the entire proposed curriculum, an acquisition professional

INTERIM CRYOGENIC PROPULSION STAGE TEST ARTICLE UNLOADED PRIOR T

NASA Image and Video Library

2016-06-20

TWO CRANES LIFT THE APPROXIMATELY 8,000-POUND INTERIM CRYOGENIC PROPULSION STAGE TEST ARTICLE OUT OF ITS CRATE AT MARSHALL. THE TEST ARTICLE ARRIVED AT MARSHALL SPACE FLIGHT CENTER VIA BARGE ON THE TENNESSEE RIVER AND WAS TRANSPORTED TO BUILDING 4649 WHERE TESTING WILL BEGIN.

SLS Intertank Test Article, ITA, is attached to crosshead of loa

NASA Image and Video Library

2018-04-04

SLS Intertank Test Article, ITA, is attached to crosshead of load test Annex, Bldg. 4619, and removed from bed of KMAG transporter. Rob Ziegler, (L), and Roger Myrick (R), of Aerie Aerospace attach load lines to Aft Load Ring of Intertank Test Article.

Risk Prediction Models in Psychiatry: Toward a New Frontier for the Prevention of Mental Illnesses.

PubMed

Bernardini, Francesco; Attademo, Luigi; Cleary, Sean D; Luther, Charles; Shim, Ruth S; Quartesan, Roberto; Compton, Michael T

2017-05-01

We conducted a systematic, qualitative review of risk prediction models designed and tested for depression, bipolar disorder, generalized anxiety disorder, posttraumatic stress disorder, and psychotic disorders. Our aim was to understand the current state of research on risk prediction models for these 5 disorders and thus future directions as our field moves toward embracing prediction and prevention. Systematic searches of the entire MEDLINE electronic database were conducted independently by 2 of the authors (from 1960 through 2013) in July 2014 using defined search criteria. Search terms included risk prediction, predictive model, or prediction model combined with depression, bipolar, manic depressive, generalized anxiety, posttraumatic, PTSD, schizophrenia, or psychosis. We identified 268 articles based on the search terms and 3 criteria: published in English, provided empirical data (as opposed to review articles), and presented results pertaining to developing or validating a risk prediction model in which the outcome was the diagnosis of 1 of the 5 aforementioned mental illnesses. We selected 43 original research reports as a final set of articles to be qualitatively reviewed. The 2 independent reviewers abstracted 3 types of data (sample characteristics, variables included in the model, and reported model statistics) and reached consensus regarding any discrepant abstracted information. Twelve reports described models developed for prediction of major depressive disorder, 1 for bipolar disorder, 2 for generalized anxiety disorder, 4 for posttraumatic stress disorder, and 24 for psychotic disorders. Most studies reported on sensitivity, specificity, positive predictive value, negative predictive value, and area under the (receiver operating characteristic) curve. Recent studies demonstrate the feasibility of developing risk prediction models for psychiatric disorders (especially psychotic disorders). The field must now advance by (1) conducting more large-scale, longitudinal studies pertaining to depression, bipolar disorder, anxiety disorders, and other psychiatric illnesses; (2) replicating and carrying out external validations of proposed models; (3) further testing potential selective and indicated preventive interventions; and (4) evaluating effectiveness of such interventions in the context of risk stratification using risk prediction models. © Copyright 2017 Physicians Postgraduate Press, Inc.

Ranking the whole MEDLINE database according to a large training set using text indexing.

PubMed

Suomela, Brian P; Andrade, Miguel A

2005-03-24

The MEDLINE database contains over 12 million references to scientific literature, with about 3/4 of recent articles including an abstract of the publication. Retrieval of entries using queries with keywords is useful for human users that need to obtain small selections. However, particular analyses of the literature or database developments may need the complete ranking of all the references in the MEDLINE database as to their relevance to a topic of interest. This report describes a method that does this ranking using the differences in word content between MEDLINE entries related to a topic and the whole of MEDLINE, in a computational time appropriate for an article search query engine. We tested the capabilities of our system to retrieve MEDLINE references which are relevant to the subject of stem cells. We took advantage of the existing annotation of references with terms from the MeSH hierarchical vocabulary (Medical Subject Headings, developed at the National Library of Medicine). A training set of 81,416 references was constructed by selecting entries annotated with the MeSH term stem cells or some child in its sub tree. Frequencies of all nouns, verbs, and adjectives in the training set were computed and the ratios of word frequencies in the training set to those in the entire MEDLINE were used to score references. Self-consistency of the algorithm, benchmarked with a test set containing the training set and an equal number of references randomly selected from MEDLINE was better using nouns (79%) than adjectives (73%) or verbs (70%). The evaluation of the system with 6,923 references not used for training, containing 204 articles relevant to stem cells according to a human expert, indicated a recall of 65% for a precision of 65%. This strategy appears to be useful for predicting the relevance of MEDLINE references to a given concept. The method is simple and can be used with any user-defined training set. Choice of the part of speech of the words used for classification has important effects on performance. Lists of words, scripts, and additional information are available from the web address http://www.ogic.ca/projects/ks2004/.

Buckling Test Results from the 8-Foot-Diameter Orthogrid-Stiffened Cylinder Test Article TA01. [Test Dates: 19-21 November 2008

NASA Technical Reports Server (NTRS)

Hilburger, Mark W.; Waters, W. Allen, Jr.; Haynie, Waddy T.

2015-01-01

Results from the testing of cylinder test article SBKF-P2-CYLTA01 (referred to herein as TA01) are presented. The testing was conducted at the Marshall Space Flight Center (MSFC), November 19?21, 2008, in support of the Shell Buckling Knockdown Factor (SBKF) Project.i The test was used to verify the performance of a newly constructed buckling test facility at MSFC and to verify the test article design and analysis approach used by the SBKF project researchers. TA01 is an 8-foot-diameter (96-inches), 78.0-inch long, aluminum-lithium (Al-Li), orthogrid-stiffened cylindrical shell similar to those used in current state-of-the-art launch vehicle structures and was designed to exhibit global buckling when subjected to compression loads. Five different load sequences were applied to TA01 during testing and included four sub-critical load sequences, i.e., loading conditions that did not cause buckling or material failure, and one final load sequence to buckling and collapse. The sub-critical load sequences consisted of either uniform axial compression loading or combined axial compression and bending and the final load sequence subjected TA01 to uniform axial compression. Traditional displacement transducers and strain gages were used to monitor the test article response at nearly 300 locations and an advanced digital image correlation system was used to obtain low-speed and high-speed full-field displacement measurements of the outer surface of the test article. Overall, the test facility and test article performed as designed. In particular, the test facility successfully applied all desired load combinations to the test article and was able to test safely into the postbuckling range of loading, and the test article failed by global buckling. In addition, the test results correlated well with initial pretest predictions.

Series length used during trend analysis affects sensitivity to changes in progression rate in the ocular hypertension treatment study.

PubMed

Gardiner, Stuart K; Demirel, Shaban; De Moraes, Carlos Gustavo; Liebmann, Jeffrey M; Cioffi, George A; Ritch, Robert; Gordon, Mae O; Kass, Michael A

2013-02-15

Trend analysis techniques to detect glaucomatous progression typically assume a constant rate of change. This study uses data from the Ocular Hypertension Treatment Study to assess whether this assumption decreases sensitivity to changes in progression rate, by including earlier periods of stability. Series of visual fields (mean 24 per eye) completed at 6-month intervals from participants randomized initially to observation were split into subseries before and after the initiation of treatment (the "split-point"). The mean deviation rate of change (MDR) was derived using these entire subseries, and using only the window length (W) tests nearest the split-point, for different window lengths of W tests. A generalized estimating equation model was used to detect changes in MDR occurring at the split-point. Using shortened subseries with W = 7 tests, the MDR slowed by 0.142 dB/y upon initiation of treatment (P < 0.001), and the proportion of eyes showing "rapid deterioration" (MDR <-0.5 dB/y with P < 5%) decreased from 11.8% to 6.5% (P < 0.001). Using the entire sequence, no significant change in MDR was detected (P = 0.796), and there was no change in the proportion of eyes progressing (P = 0.084). Window lengths 6 ≤ W ≤ 9 produced similar benefits. Event analysis revealed a beneficial treatment effect in this dataset. This effect was not detected by linear trend analysis applied to entire series, but was detected when using shorter subseries of length between six and nine fields. Using linear trend analysis on the entire field sequence may not be optimal for detecting and monitoring progression. Nonlinear analyses may be needed for long series of fields. (ClinicalTrials.gov number, NCT00000125.).

The upgrade system of BESIII ETOF with MRPC technology

NASA Astrophysics Data System (ADS)

Wang, X. Z.; Sun, Y. J.; Li, C.; Heng, Y. K.; Wu, Z.; Cao, P.; Dai, H. L.; Ji, X. L.; Gong, W. X.; Liu, Z.; Luo, X. L.; Sun, W. J.; Wang, S. Y.; Wang, Y.; Yang, R. X.; Ye, M.; Zhao, J. L.

2016-08-01

An upgrade, based on Multigap Resistive Plate Chamber (MRPC) technology, of the endcap Time-Of-Flight (ETOF) detector of the Beijing Spectrometer III (BESIII) has been proposed for the replacement of the current scintillator + PMT based ETOF, with the aim of improving the time resolution down to 80 ps sigma. This improvement will enhance the particle identification capability to meet the higher precision requirements of physics. The ETOF system including MRPC modules, Front End Electronics (FEE), CLOCK module, fast control boards and Time to Digital modules (TDIG), has been designed, constructed and parts of the ETOF system have seperately tested. Aiming at examining the quality of entire ETOF system and training the operation of all participated instruments, a cosmic ray test system was built and tested in the laboratory for about three months to guarantee the performance. In this paper the results of the test are presented indicating that the entire ETOF system works well and satisfies the requirements of the upgrade.

Service Life Extension of the Propulsion System of Long-Term Manned Orbital Stations

NASA Technical Reports Server (NTRS)

Kamath, Ulhas; Kuznetsov, Sergei; Spencer, Victor

2014-01-01

One of the critical non-replaceable systems of a long-term manned orbital station is the propulsion system. Since the propulsion system operates beginning with the launch of station elements into orbit, its service life determines the service life of the station overall. Weighing almost a million pounds, the International Space Station (ISS) is about four times as large as the Russian space station Mir and about five times as large as the U.S. Skylab. Constructed over a span of more than a decade with the help of over 100 space flights, elements and modules of the ISS provide more research space than any spacecraft ever built. Originally envisaged for a service life of fifteen years, this Earth orbiting laboratory has been in orbit since 1998. Some elements that have been launched later in the assembly sequence were not yet built when the first elements were placed in orbit. Hence, some of the early modules that were launched at the inception of the program were already nearing the end of their design life when the ISS was finally ready and operational. To maximize the return on global investments on ISS, it is essential for the valuable research on ISS to continue as long as the station can be sustained safely in orbit. This paper describes the work performed to extend the service life of the ISS propulsion system. A system comprises of many components with varying failure rates. Reliability of a system is the probability that it will perform its intended function under encountered operating conditions, for a specified period of time. As we are interested in finding out how reliable a system would be in the future, reliability expressed as a function of time provides valuable insight. In a hypothetical bathtub shaped failure rate curve, the failure rate, defined as the number of failures per unit time that a currently healthy component will suffer in a given future time interval, decreases during infant-mortality period, stays nearly constant during the service life and increases at the end when the design service life ends and wear-out phase begins. However, the component failure rates do not remain constant over the entire cycle life. The failure rate depends on various factors such as design complexity, current age of the component, operating conditions, severity of environmental stress factors, etc. Development, qualification and acceptance test processes provide rigorous screening of components to weed out imperfections that might otherwise cause infant mortality failures. If sufficient samples are tested to failure, the failure time versus failure quantity can be analyzed statistically to develop a failure probability distribution function (PDF), a statistical model of the probability of failure versus time. Driven by cost and schedule constraints however, spacecraft components are generally not tested in large numbers. Uncertainties in failure rate and remaining life estimates increase when fewer units are tested. To account for this, spacecraft operators prefer to limit useful operations to a period shorter than the maximum demonstrated service life of the weakest component. Running each component to its failure to determine the maximum possible service life of a system can become overly expensive and impractical. Spacecraft operators therefore, specify the required service life and an acceptable factor of safety (FOS). The designers use these requirements to limit the life test duration. Midway through the design life, when benefits justify additional investments, supplementary life test may be performed to demonstrate the capability to safely extend the service life of the system. An innovative approach is required to evaluate the entire system, without having to go through an elaborate test program of propulsion system elements. Evaluating every component through a brute force test program would be a cost prohibitive and time consuming endeavor. ISS propulsion system components were designed and built decades ago. There are no representative ground test articles for some of the components. A 'test everything' approach would require manufacturing new test articles. The paper outlines some of the techniques used for selective testing, by way of cherry picking candidate components based on failure mode effects analysis, system level impacts, hazard analysis, etc. The type of testing required for extending the service life depends on the design and criticality of the component, failure modes and failure mechanisms, life cycle margin provided by the original certification, operational and environmental stresses encountered, etc. When specific failure mechanism being considered and the underlying relationship of that mode to the stresses provided in the test can be correlated by supporting analysis, time and effort required for conducting life extension testing can be significantly reduced. Exposure to corrosive propellants over long periods of time, for instance, lead to specific failure mechanisms in several components used in the propulsion system. Using Arrhenius model, which is tied to chemically dependent failure mechanisms such as corrosion or chemical reactions, it is possible to subject carefully selected test articles to accelerated life test. Arrhenius model reflects the proportional relationship between time to failure of a component and the exponential of the inverse of absolute temperature acting on the component. The acceleration factor is used to perform tests at higher stresses that allow direct correlation between the times to failure at a high test temperature to the temperatures to be expected in actual use. As long as the temperatures are such that new failure mechanisms are not introduced, this becomes a very useful method for testing to failure a relatively small sample of items for a much shorter amount of time. In this article, based on the example of the propulsion system of the first ISS module Zarya, theoretical approaches and practical activities of extending the service life of the propulsion system are reviewed with the goal of determining the maximum duration of its safe operation.

Testing with Feedback Yields Potent, but Piecewise, Learning of History and Biology Facts

ERIC Educational Resources Information Center

Pan, Steven C.; Gopal, Arpita; Rickard, Timothy C.

2016-01-01

Does correctly answering a test question about a multiterm fact enhance memory for the entire fact? We explored that issue in 4 experiments. Subjects first studied Advanced Placement History or Biology facts. Half of those facts were then restudied, whereas the remainder were tested using "5 W" (i.e., "who, what, when, where",…

How We Define Success: Holding Values in an Era of High Stakes Accountability

ERIC Educational Resources Information Center

Gasoi, Emily

2009-01-01

In the current climate of high stakes testing and tough love rhetoric, many educational stakeholders have become increasingly reliant on standardized test scores to determine whether or not individual students, teachers, and schools--and even entire districts and states--are successful. In contrast to the black and white picture that test-driven…

49 CFR 178.345-13 - Pressure and leakage tests.

Code of Federal Regulations, 2014 CFR

2014-10-01

... entire cargo tank surface is inspected for leakage and other sign of defects. The inspection method must... Specifications for Containers for Motor Vehicle Transportation § 178.345-13 Pressure and leakage tests. (a) Each cargo tank must be pressure and leakage tested in accordance with this section and §§ 178.346-5, 178.347...

49 CFR 178.345-13 - Pressure and leakage tests.

Code of Federal Regulations, 2012 CFR

2012-10-01

... entire cargo tank surface is inspected for leakage and other sign of defects. The inspection method must... Specifications for Containers for Motor Vehicle Transportation § 178.345-13 Pressure and leakage tests. (a) Each cargo tank must be pressure and leakage tested in accordance with this section and §§ 178.346-5, 178.347...

49 CFR 178.345-13 - Pressure and leakage tests.

Code of Federal Regulations, 2013 CFR

2013-10-01

... entire cargo tank surface is inspected for leakage and other sign of defects. The inspection method must... Specifications for Containers for Motor Vehicle Transportation § 178.345-13 Pressure and leakage tests. (a) Each cargo tank must be pressure and leakage tested in accordance with this section and §§ 178.346-5, 178.347...

49 CFR 178.345-13 - Pressure and leakage tests.

Code of Federal Regulations, 2011 CFR

2011-10-01

... entire cargo tank surface is inspected for leakage and other sign of defects. The inspection method must... Specifications for Containers for Motor Vehicle Transportation § 178.345-13 Pressure and leakage tests. (a) Each cargo tank must be pressure and leakage tested in accordance with this section and §§ 178.346-5, 178.347...

The Test of American Culture. Doshisha Studies in English No. 22.

ERIC Educational Resources Information Center

Kitao, Kenji

A test was developed to determine how much Japanese students know about American culture. This written test, which was entirely in English and covered fifty areas of culture and "Culture," was administered to 200 Japanese students studying in Japan and at Kansas University (KU). Results for these students were measured against a standard…

An Evaluation of the Additional Acoustic Power Needed to Overcome the Effects of a Test-Article's Absorption During Reverberant Chamber Acoustic Testing of Spaceflight Hardware

NASA Technical Reports Server (NTRS)

Hozman, Aron D.; Hughes, William O.

2014-01-01

The exposure of a customer's aerospace test-article to a simulated acoustic launch environment is typically performed in a reverberant acoustic test chamber. The acoustic pre-test runs that will ensure that the sound pressure levels of this environment can indeed be met by a test facility are normally performed without a test-article dynamic simulator of representative acoustic absorption and size. If an acoustic test facility's available acoustic power capability becomes maximized with the test-article installed during the actual test then the customer's environment requirement may become compromised. In order to understand the risk of not achieving the customer's in-tolerance spectrum requirement with the test-article installed, an acoustic power margin evaluation as a function of frequency may be performed by the test facility. The method for this evaluation of acoustic power will be discussed in this paper. This method was recently applied at the NASA Glenn Research Center Plum Brook Station's Reverberant Acoustic Test Facility for the SpaceX Falcon 9 Payload Fairing acoustic test program.

An Evaluation of the Additional Acoustic Power Needed to Overcome the Effects of a Test-Article's Absorption during Reverberant Chamber Acoustic Testing of Spaceflight Hardware

NASA Technical Reports Server (NTRS)

Hozman, Aron D.; Hughes, William O.

2014-01-01

The exposure of a customers aerospace test-article to a simulated acoustic launch environment is typically performed in a reverberant acoustic test chamber. The acoustic pre-test runs that will ensure that the sound pressure levels of this environment can indeed be met by a test facility are normally performed without a test-article dynamic simulator of representative acoustic absorption and size. If an acoustic test facilitys available acoustic power capability becomes maximized with the test-article installed during the actual test then the customers environment requirement may become compromised. In order to understand the risk of not achieving the customers in-tolerance spectrum requirement with the test-article installed, an acoustic power margin evaluation as a function of frequency may be performed by the test facility. The method for this evaluation of acoustic power will be discussed in this paper. This method was recently applied at the NASA Glenn Research Center Plum Brook Stations Reverberant Acoustic Test Facility for the SpaceX Falcon 9 Payload Fairing acoustic test program.

Are sex differences in fundamental motor skills uniform throughout the entire preschool period?

PubMed

Kokštejn, Jakub; Musálek, Martin; Tufano, James J

2017-01-01

The aim of this study was to assess differences in fundamental motor skills (FMS) proficiency between boys and girls of each age group, independently, across the entire preschool period. Using the Movement Assessment Battery for Children-second edition, FMS proficiency was tested in 325 preschoolers (4.9 ± 1.1 y, range 3-6) using a cross-sectional design. Compared to boys of the same age, 3- and 4-year-old girls had greater total (p < .01), fine motor skill (p < .01), and balance scores (p < .05). There were no sex differences for total test or balance scores in 5- and 6-year-olds, but 6-year-old boys outperformed girls in aiming and catching (p < .001). These data not only agree with previous research in that sex differences in FMS proficiency exist in preschool children, but the data also show that differences may not be uniform throughout the whole preschool period when analyzing by age. To avoid under- or overestimating FMS proficiency and subsequently prescribing inaccurate motor intervention programs, FMS proficiency normative values should be age- and sex-specific throughout the entire preschool period.

A Statistical Procedure for Testing Unusually Frequent Exactly Matching Responses and Nearly Matching Responses. Research Report. ETS RR-17-23

ERIC Educational Resources Information Center

Haberman, Shelby J.; Lee, Yi-Hsuan

2017-01-01

In investigations of unusual testing behavior, a common question is whether a specific pattern of responses occurs unusually often within a group of examinees. In many current tests, modern communication techniques can permit quite large numbers of examinees to share keys, or common response patterns, to the entire test. To address this issue,…

Creatinine clearance test

MedlinePlus

Serum creatinine clearance; Kidney function - creatinine clearance; Renal function - creatinine clearance ... the body entirely by the kidneys. If kidney function is abnormal, creatinine level increases in the blood ...

On P values and effect modification.

PubMed

Mayer, Martin

2017-12-01

A crucial element of evidence-based healthcare is the sound understanding and use of statistics. As part of instilling sound statistical knowledge and practice, it seems useful to highlight instances of unsound statistical reasoning or practice, not merely in captious or vitriolic spirit, but rather, to use such error as a springboard for edification by giving tangibility to the concepts at hand and highlighting the importance of avoiding such error. This article aims to provide an instructive overview of two key statistical concepts: effect modification and P values. A recent article published in the Journal of the American College of Cardiology on side effects related to statin therapy offers a notable example of errors in understanding effect modification and P values, and although not so critical as to entirely invalidate the article, the errors still demand considerable scrutiny and correction. In doing so, this article serves as an instructive overview of the statistical concepts of effect modification and P values. Judicious handling of statistics is imperative to avoid muddying their utility. This article contributes to the body of literature aiming to improve the use of statistics, which in turn will help facilitate evidence appraisal, synthesis, translation, and application.

Trend analysis of precipitation in Jharkhand State, India. Investigating precipitation variability in Jharkhand State

NASA Astrophysics Data System (ADS)

Chandniha, Surendra Kumar; Meshram, Sarita Gajbhiye; Adamowski, Jan Franklin; Meshram, Chandrashekhar

2017-10-01

Jharkhand is one of the eastern states of India which has an agriculture-based economy. Uncertain and erratic distribution of precipitation as well as a lack of state water resources planning is the major limitation to crop growth in the region. In this study, the spatial and temporal variability in precipitation in the state was examined using a monthly precipitation time series of 111 years (1901-2011) from 18 meteorological stations. Autocorrelation and Mann-Kendall/modified Mann-Kendall tests were utilized to detect possible trends, and the Theil and Sen slope estimator test was used to determine the magnitude of change over the entire time series. The most probable change year (change point) was detected using the Pettitt-Mann-Whitney test, and the entire time series was sub-divided into two parts: before and after the change point. Arc-Map 9.3 software was utilized to assess the spatial patterns of the trends over the entire state. Annual precipitation exhibited a decreasing trend in 5 out of 18 stations during the whole period. For annual, monsoon and winter periods of precipitation, the slope test indicated a decreasing trend for all stations during 1901-2011. The highest variability was observed in post-monsoon precipitation (77.87 %) and the lowest variability was observed in the annual series (15.76 %) over the 111 years. An increasing trend in precipitation in the state was found during the period 1901-1949, which was reversed during the subsequent period (1950-2011).

Personnel controlling system principles and structural goals of the industrial companies

NASA Astrophysics Data System (ADS)

Pimenova, Anna; Kuzmina, Svetlana; Zavialov, Kirill; Ushakova, Elena

2017-10-01

This article peruses the basics of the controlling system, its functions and structural phases of the industrial companies. The personnel controlling of the industrial companies (for examples transportation or energy company) is examined in detail. Controlling system occurs applicable within various activity fields of an enterprise. Modern approaches of the domestic scholars are inspected. Goals and focuses of the personnel controlling system of the industrial companies have been analyzed. Foremost it occurs crucial to analyze and define the entire labor process to figure out primary requirements issued to the labor and employees. In article is offered the road map to follow to structure the purposes of all management system of personnel in the specific organization - in the transportation or energy company or other enterprises.

A Data Scientist's Guide to Start-Ups.

PubMed

Provost, Foster; Webb, Geoffrey I; Bekkerman, Ron; Etzioni, Oren; Fayyad, Usama; Perlich, Claudia

2014-09-01

In August 2013, we held a panel discussion at the KDD 2013 conference in Chicago on the subject of data science, data scientists, and start-ups. KDD is the premier conference on data science research and practice. The panel discussed the pros and cons for top-notch data scientists of the hot data science start-up scene. In this article, we first present background on our panelists. Our four panelists have unquestionable pedigrees in data science and substantial experience with start-ups from multiple perspectives (founders, employees, chief scientists, venture capitalists). For the casual reader, we next present a brief summary of the experts' opinions on eight of the issues the panel discussed. The rest of the article presents a lightly edited transcription of the entire panel discussion.

Diffusion Tractography of the Entire Left Ventricle by Using Free-breathing Accelerated Simultaneous Multisection Imaging

PubMed Central

Reese, Timothy G.; Jackowski, Marcel P.; Cauley, Stephen F.; Setsompop, Kawin; Bhat, Himanshu; Sosnovik, David E.

2017-01-01

Purpose To develop a clinically feasible whole-heart free-breathing diffusion-tensor (DT) magnetic resonance (MR) imaging approach with an imaging time of approximately 15 minutes to enable three-dimensional (3D) tractography. Materials and Methods The study was compliant with HIPAA and the institutional review board and required written consent from the participants. DT imaging was performed in seven healthy volunteers and three patients with pulmonary hypertension by using a stimulated echo sequence. Twelve contiguous short-axis sections and six four-chamber sections that covered the entire left ventricle were acquired by using simultaneous multisection (SMS) excitation with a blipped-controlled aliasing in parallel imaging readout. Rate 2 and rate 3 SMS excitation was defined as two and three times accelerated in the section axis, respectively. Breath-hold and free-breathing images with and without SMS acceleration were acquired. Diffusion-encoding directions were acquired sequentially, spatiotemporally registered, and retrospectively selected by using an entropy-based approach. Myofiber helix angle, mean diffusivity, fractional anisotropy, and 3D tractograms were analyzed by using paired t tests and analysis of variance. Results No significant differences (P > .63) were seen between breath-hold rate 3 SMS and free-breathing rate 2 SMS excitation in transmural myofiber helix angle, mean diffusivity (mean ± standard deviation, [0.89 ± 0.09] × 10−3 mm2/sec vs [0.9 ± 0.09] × 10−3 mm2/sec), or fractional anisotropy (0.43 ± 0.05 vs 0.42 ± 0.06). Three-dimensional tractograms of the left ventricle with no SMS and rate 2 and rate 3 SMS excitation were qualitatively similar. Conclusion Free-breathing DT imaging of the entire human heart can be performed in approximately 15 minutes without section gaps by using SMS excitation with a blipped-controlled aliasing in parallel imaging readout, followed by spatiotemporal registration and entropy-based retrospective image selection. This method may lead to clinical translation of whole-heart DT imaging, enabling broad application in patients with cardiac disease. © RSNA, 2016 Online supplemental material is available for this article. PMID:27681278

Diffusion Tractography of the Entire Left Ventricle by Using Free-breathing Accelerated Simultaneous Multisection Imaging.

PubMed

Mekkaoui, Choukri; Reese, Timothy G; Jackowski, Marcel P; Cauley, Stephen F; Setsompop, Kawin; Bhat, Himanshu; Sosnovik, David E

2017-03-01

Purpose To develop a clinically feasible whole-heart free-breathing diffusion-tensor (DT) magnetic resonance (MR) imaging approach with an imaging time of approximately 15 minutes to enable three-dimensional (3D) tractography. Materials and Methods The study was compliant with HIPAA and the institutional review board and required written consent from the participants. DT imaging was performed in seven healthy volunteers and three patients with pulmonary hypertension by using a stimulated echo sequence. Twelve contiguous short-axis sections and six four-chamber sections that covered the entire left ventricle were acquired by using simultaneous multisection (SMS) excitation with a blipped-controlled aliasing in parallel imaging readout. Rate 2 and rate 3 SMS excitation was defined as two and three times accelerated in the section axis, respectively. Breath-hold and free-breathing images with and without SMS acceleration were acquired. Diffusion-encoding directions were acquired sequentially, spatiotemporally registered, and retrospectively selected by using an entropy-based approach. Myofiber helix angle, mean diffusivity, fractional anisotropy, and 3D tractograms were analyzed by using paired t tests and analysis of variance. Results No significant differences (P > .63) were seen between breath-hold rate 3 SMS and free-breathing rate 2 SMS excitation in transmural myofiber helix angle, mean diffusivity (mean ± standard deviation, [0.89 ± 0.09] × 10 -3 mm 2 /sec vs [0.9 ± 0.09] × 10 -3 mm 2 /sec), or fractional anisotropy (0.43 ± 0.05 vs 0.42 ± 0.06). Three-dimensional tractograms of the left ventricle with no SMS and rate 2 and rate 3 SMS excitation were qualitatively similar. Conclusion Free-breathing DT imaging of the entire human heart can be performed in approximately 15 minutes without section gaps by using SMS excitation with a blipped-controlled aliasing in parallel imaging readout, followed by spatiotemporal registration and entropy-based retrospective image selection. This method may lead to clinical translation of whole-heart DT imaging, enabling broad application in patients with cardiac disease. © RSNA, 2016 Online supplemental material is available for this article.

Methodological challenges when doing research that includes ethnic minorities: a scoping review.

PubMed

Morville, Anne-Le; Erlandsson, Lena-Karin

2016-11-01

There are challenging methodological issues in obtaining valid and reliable results on which to base occupational therapy interventions for ethnic minorities. The aim of this scoping review is to describe the methodological problems within occupational therapy research, when ethnic minorities are included. A thorough literature search yielded 21 articles obtained from the scientific databases PubMed, Cinahl, Web of Science and PsychInfo. Analysis followed Arksey and O'Malley's framework for scoping reviews, applying content analysis. The results showed methodological issues concerning the entire research process from defining and recruiting samples, the conceptual understanding, lack of appropriate instruments, data collection using interpreters to analyzing data. In order to avoid excluding the ethnic minorities from adequate occupational therapy research and interventions, development of methods for the entire research process is needed. It is a costly and time-consuming process, but the results will be valid and reliable, and therefore more applicable in clinical practice.

Challenges facing the finance reform of the health system in Chile.

PubMed

Herrera, Tania

2014-05-28

Financing is one of the key functions of health systems, which includes the processes of revenue collection, fund pooling and acquisitions in order to ensure access to healthcare for the entire population. The article analyzes the financing model of the Chilean health system in terms of the first two processes, confirming low public spending on healthcare and high out-of-pocket expenditure, in addition to an appropriation of public resources by private insurers and providers. Insofar as pooling, there is lack of solidarity and risk sharing leading to segmentation of the population that is not consistent with the concept of social security, undermines equity and reduces system-wide efficiency. There is a pressing need to jumpstart reforms that address these issues. Treatments must be considered together with public health concerns and primary care in order to ensure the right to health of the entire population.

Influence of family environment on children's oral health: a systematic review.

PubMed

Castilho, Aline Rogéria Freire de; Mialhe, Fábio Luiz; Barbosa, Taís de Souza; Puppin-Rontani, Regina Maria

2013-01-01

To review current models and scientific evidence on the influence of parents' oral health behaviors on their children's dental caries. MEDLINE articles published between 1980 and June, 2012. Original research articles on parents' oral health behavior were reviewed. A total of 218 citations were retrieved, and 13 articles were included in the analysis. The studies were eligible for review if they matched the following inclusion criteria: (1) they evaluated a possible association between dental caries and parents' oral-health-related behaviors, and (2) the study methodology included oral clinical examination. The main search terms were "oral health", "parental attitudes", "parental knowledge", and "dental caries". : 13 experimental studies contributed data to the synthesis. Original articles, reviews, and chapters in textbooks were also considered. Parents' dental health habits influence their children's oral health. Oral health education programs aimed at preventive actions are needed to provide children not only with adequate oral health, but better quality of life. Special attention should be given to the entire family, concerning their lifestyle and oral health habits. Copyright © 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

9 CFR 113.409 - Tuberculin-PPD Bovis, Intradermic.

Code of Federal Regulations, 2011 CFR

2011-01-01

... serial shall be tested for purity, safety, potency, and special chemical characteristics in accordance... tuberculin by clipping the hair from the entire abdominal and flank areas, applying a depilatory agent for 5... index is less than 400 square millimeters. (d) Special chemical tests and requirements. Final container...

9 CFR 113.409 - Tuberculin-PPD Bovis, Intradermic.

Code of Federal Regulations, 2012 CFR

2012-01-01

... serial shall be tested for purity, safety, potency, and special chemical characteristics in accordance... tuberculin by clipping the hair from the entire abdominal and flank areas, applying a depilatory agent for 5... index is less than 400 square millimeters. (d) Special chemical tests and requirements. Final container...

9 CFR 113.409 - Tuberculin-PPD Bovis, Intradermic.

Code of Federal Regulations, 2013 CFR

2013-01-01

... serial shall be tested for purity, safety, potency, and special chemical characteristics in accordance... tuberculin by clipping the hair from the entire abdominal and flank areas, applying a depilatory agent for 5... index is less than 400 square millimeters. (d) Special chemical tests and requirements. Final container...

9 CFR 113.409 - Tuberculin-PPD Bovis, Intradermic.

Code of Federal Regulations, 2014 CFR

2014-01-01

... serial shall be tested for purity, safety, potency, and special chemical characteristics in accordance... tuberculin by clipping the hair from the entire abdominal and flank areas, applying a depilatory agent for 5... index is less than 400 square millimeters. (d) Special chemical tests and requirements. Final container...

Pyrazolo[3,4-c]isothiazole and isothiazolo[4,3-d]isoxazole derivatives as antifungal agents.

PubMed

Vicentini, Chiara Beatrice; Romagnoli, Carlo; Manfredini, Stefano; Rossi, Damiano; Mares, Donatella

2011-05-01

The diseases of plants and humans due to pathogenic fungi are increasing. Among the substances used to combat fungi, the azoles are of primary interest, both in agricultural field both in health. To avoid fungal resistance phenomena, the synthesis and tests of new derivatives are necessary. This article discusses the synthesis and the antifungal activity of pyrazolo[3,4-c]isothiazole and isothiazolo[4,3-d]isoxazole derivatives against three fungi that are pathogenic only for plants and two fungi that are opportunistic in humans and plants. The compounds were prepared starting from 2-cyano-3-ethoxy-2-butenethioamide. The antifungal activity of the compounds was determined by measuring the inhibition of growth of the fungi tested at 20, 50, and 100 µg/mL in comparison with the controls. Results demonstrated that several compounds were able to control the mycelial growth of the tested fungi, even if they showed different sensitivity to the different azole-derivatives. In general Magnaporthe grisea (T.T. Hebert) Yaegashi & Udagawa was the most sensitive fungus, being blocked almost entirely by 4-chloro derivative even at 20 µg/mL, a concentration at which the reference commercial compound tricyclazole was nearly ineffective. These findings demonstrate that the pyrazolo[3,4-c]isothiazole derivatives have a wide spectrum of activity on phytopathogenic and opportunistic fungi. In particular the 4-chloro derivative seems to have a great potential as new product to combat M. grisea in the agricultural field.

Visual System Involvement in Patients with Newly Diagnosed Parkinson Disease.

PubMed

Arrigo, Alessandro; Calamuneri, Alessandro; Milardi, Demetrio; Mormina, Enricomaria; Rania, Laura; Postorino, Elisa; Marino, Silvia; Di Lorenzo, Giuseppe; Anastasi, Giuseppe Pio; Ghilardi, Maria Felice; Aragona, Pasquale; Quartarone, Angelo; Gaeta, Michele

2017-12-01

Purpose To assess intracranial visual system changes of newly diagnosed Parkinson disease in drug-naïve patients. Materials and Methods Twenty patients with newly diagnosed Parkinson disease and 20 age-matched control subjects were recruited. Magnetic resonance (MR) imaging (T1-weighted and diffusion-weighted imaging) was performed with a 3-T MR imager. White matter changes were assessed by exploring a white matter diffusion profile by means of diffusion-tensor imaging-based parameters and constrained spherical deconvolution-based connectivity analysis and by means of white matter voxel-based morphometry (VBM). Alterations in occipital gray matter were investigated by means of gray matter VBM. Morphologic analysis of the optic chiasm was based on manual measurement of regions of interest. Statistical testing included analysis of variance, t tests, and permutation tests. Results In the patients with Parkinson disease, significant alterations were found in optic radiation connectivity distribution, with decreased lateral geniculate nucleus V2 density (F, -8.28; P < .05), a significant increase in optic radiation mean diffusivity (F, 7.5; P = .014), and a significant reduction in white matter concentration. VBM analysis also showed a significant reduction in visual cortical volumes (P < .05). Moreover, the chiasmatic area and volume were significantly reduced (P < .05). Conclusion The findings show that visual system alterations can be detected in early stages of Parkinson disease and that the entire intracranial visual system can be involved. © RSNA, 2017 Online supplemental material is available for this article.

Database citation in supplementary data linked to Europe PubMed Central full text biomedical articles.

PubMed

Kafkas, Şenay; Kim, Jee-Hyub; Pi, Xingjun; McEntyre, Johanna R

2015-01-01

In this study, we present an analysis of data citation practices in full text research articles and their corresponding supplementary data files, made available in the Open Access set of articles from Europe PubMed Central. Our aim is to investigate whether supplementary data files should be considered as a source of information for integrating the literature with biomolecular databases. Using text-mining methods to identify and extract a variety of core biological database accession numbers, we found that the supplemental data files contain many more database citations than the body of the article, and that those citations often take the form of a relatively small number of articles citing large collections of accession numbers in text-based files. Moreover, citation of value-added databases derived from submission databases (such as Pfam, UniProt or Ensembl) is common, demonstrating the reuse of these resources as datasets in themselves. All the database accession numbers extracted from the supplementary data are publicly accessible from http://dx.doi.org/10.5281/zenodo.11771. Our study suggests that supplementary data should be considered when linking articles with data, in curation pipelines, and in information retrieval tasks in order to make full use of the entire research article. These observations highlight the need to improve the management of supplemental data in general, in order to make this information more discoverable and useful.

An Analysis of 2.3 Million Participations in the Continuing Medical Education Program of a General Medical Journal: Suitability, User Characteristics, and Evaluation by Readers.

PubMed

Christ, Hildegard; Franklin, Jeremy; Griebenow, Reinhard; Baethge, Christopher

2017-04-03

Physicians frequently use continuing medical education (CME) in journals. However, little is known of the evaluation of journal CME by readers and also user and participation characteristics. Deutsches Ärzteblatt, the journal of the German Medical Association, is distributed to every physician in Germany and regularly offers its readers CME articles. Therefore, it provides a unique opportunity to analyze a journal CME program directed at an entire population of physicians. The aim is to show key sociodemographic characteristics of participants, frequency and temporal distributions of participations, and to analyze whether the articles are suitable for a general medical audience, how physicians rate the CME articles, how successful they were in answering simple multiple-choice questions, and to detect distinct clusters of participants. Using obligatory online evaluation forms and multiple-choice questions, we analyzed all participations of the entire 142 CME articles published between September 2004 and February 2014. We compared demographic characteristics of participants with official figures on those characteristics as provided by the German Medical Association. A total of 128,398 physicians and therapists (male: 54.64%, 70,155/128,393; median age class 40 to 49 years) participated 2,339,802 times (mean 16,478, SD 6436 participations/article). Depending on the year, between 12.33% (44,064/357,252) and 16.15% (50,259/311,230) of all physicians in the country participated at least once. The CME program was disproportionally popular with physicians in private practice, and many participations took place in the early mornings and evenings (4544.53%, 1,041,931/2,339,802) as well as over the weekend (28.70%, 671,563/2,339,802). Participation by specialty (ranked in descending order) was internal medicine (18.25%, 23,434/128,392), general medicine (16.38%, 21,033/128,392), anesthesiology (10.00%, 12,840/128,392), and surgery (7.06%, 9059/128,392). Participants rated the CME articles as intelligible to a wider medical audience and filling clinically relevant knowledge gaps; 78.57% (1,838,358/2,339,781) of the sample gave the CME articles very good or good marks. Cluster analysis revealed three groups, one comprised of only women, with two-thirds working in private practice. The CME article series of Deutsches Ärzteblatt is used on a regular basis by a considerable proportion of all physicians in Germany; its multidisciplinary articles are suitable to a broad spectrum of medical specialties. The program seems to be particularly attractive for physicians in private practice and those who want to participate from their homes and on weekends. Although many physicians emphasize that the articles address gaps in knowledge, it remains to be investigated how this impacts professional performance and patient outcomes. ©Hildegard Christ, Jeremy Franklin, Reinhard Griebenow, Christopher Baethge. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 03.04.2017.

Can commonly-used fan-driven air cleaning technologies improve indoor air quality? A literature review

NASA Astrophysics Data System (ADS)

Zhang, Yinping; Mo, Jinhan; Li, Yuguo; Sundell, Jan; Wargocki, Pawel; Zhang, Jensen; Little, John C.; Corsi, Richard; Deng, Qihong; Leung, Michael H. K.; Fang, Lei; Chen, Wenhao; Li, Jinguang; Sun, Yuexia

2011-08-01

Air cleaning techniques have been applied worldwide with the goal of improving indoor air quality. The effectiveness of applying these techniques varies widely, and pollutant removal efficiency is usually determined in controlled laboratory environments which may not be realized in practice. Some air cleaners are largely ineffective, and some produce harmful by-products. To summarize what is known regarding the effectiveness of fan-driven air cleaning technologies, a state-of-the-art review of the scientific literature was undertaken by a multidisciplinary panel of experts from Europe, North America, and Asia with expertise in air cleaning, aerosol science, medicine, chemistry and ventilation. The effects on health were not examined. Over 26,000 articles were identified in major literature databases; 400 were selected as being relevant based on their titles and abstracts by the first two authors, who further reduced the number of articles to 160 based on the full texts. These articles were reviewed by the panel using predefined inclusion criteria during their first meeting. Additions were also made by the panel. Of these, 133 articles were finally selected for detailed review. Each article was assessed independently by two members of the panel and then judged by the entire panel during a consensus meeting. During this process 59 articles were deemed conclusive and their results were used for final reporting at their second meeting. The conclusions are that: (1) None of the reviewed technologies was able to effectively remove all indoor pollutants and many were found to generate undesirable by-products during operation. (2) Particle filtration and sorption of gaseous pollutants were among the most effective air cleaning technologies, but there is insufficient information regarding long-term performance and proper maintenance. (3) The existing data make it difficult to extract information such as Clean Air Delivery Rate (CADR), which represents a common benchmark for comparing the performance of different air cleaning technologies. (4) To compare and select suitable indoor air cleaning devices, a labeling system accounting for characteristics such as CADR, energy consumption, volume, harmful by-products, and life span is necessary. For that purpose, a standard test room and condition should be built and studied. (5) Although there is evidence that some air cleaning technologies improve indoor air quality, further research is needed before any of them can be confidently recommended for use in indoor environments.

Design of 8-ft-Diameter Barrel Test Article Attachment Rings for Shell Buckling Knockdown Factor Project

NASA Technical Reports Server (NTRS)

Lovejoy, Andrew E.; Hilburger, Mark W.

2010-01-01

The Shell Buckling Knockdown Factor (SBKF) project includes the testing of sub-scale cylinders to validate new shell buckling knockdown factors for use in the design of the Ares-I and Ares-V launch vehicles. Test article cylinders represent various barrel segments of the Ares-I and Ares-V vehicles, and also include checkout test articles. Testing will be conducted at Marshall Space Flight Center (MSFC) for test articles having an eight-foot diameter outer mold line (OML) and having lengths that range from three to ten feet long. Both ends of the test articles will be connected to the test apparatus using attachment rings. Three multiple-piece and one single-piece design for the attachment rings were developed and analyzed. The single-piece design was chosen and will be fabricated from either steel or aluminum (Al) depending on the required safety factors (SF) for test hardware. This report summarizes the design and analysis of these attachment ring concepts.

An Evaluation of the Additional Acoustic Power Needed to Overcome the Effects of a Test-Articles Absorption During Reverberant Chamber Acoustic Testing of Spaceflight Hardware

NASA Technical Reports Server (NTRS)

Hozman, Aron D.; Hughes, William O.

2014-01-01

It is important to realize that some test-articles may have significant sound absorption that may challenge the acoustic power capabilities of a test facility. Therefore, to mitigate this risk of not being able to meet the customers target spectrum, it is prudent to demonstrate early-on an increased acoustic power capability which compensates for this test-article absorption. This paper describes a concise method to reduce this risk when testing aerospace test-articles which have significant absorption. This method was successfully applied during the SpaceX Falcon 9 Payload Fairing acoustic test program at the NASA Glenn Research Center Plum Brook Stations RATF.

Tissue Engineering and Regenerative Medicine 2015: A Year in Review.

PubMed

Wobma, Holly; Vunjak-Novakovic, Gordana

2016-04-01

This may be the most exciting time ever for the field of tissue engineering and regenerative medicine (TERM). After decades of progress, it has matured, integrated, and diversified into entirely new areas, and it is starting to make the pivotal shift toward translation. The most exciting science and applications continue to emerge at the boundaries of disciplines, through increasingly effective interactions between stem cell biologists, bioengineers, clinicians, and the commercial sector. In this "Year in Review," we highlight some of the major advances reported over the last year (Summer 2014-Fall 2015). Using a methodology similar to that established in previous years, we identified four areas that generated major progress in the field: (i) pluripotent stem cells, (ii) microtissue platforms for drug testing and disease modeling, (iii) tissue models of cancer, and (iv) whole organ engineering. For each area, we used some of the most impactful articles to illustrate the important concepts and results that advanced the state of the art of TERM. We conclude with reflections on emerging areas and perspectives for future development in the field.

Time-Resolved Diffuse Optical Spectroscopy and Imaging Using Solid-State Detectors: Characteristics, Present Status, and Research Challenges.

PubMed

Alayed, Mrwan; Deen, M Jamal

2017-09-14

Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-invasive imaging modalities that have wide spread potential applications in many fields, particularly for structural and functional imaging in medicine. In this article, we review time-resolved diffuse optical imaging (TR-DOI) systems using solid-state detectors with a special focus on Single-Photon Avalanche Diodes (SPADs) and Silicon Photomultipliers (SiPMs). These TR-DOI systems can be categorized into two types based on the operation mode of the detector (free-running or time-gated). For the TR-DOI prototypes, the physical concepts, main components, figures-of-merit of detectors, and evaluation parameters are described. The performance of TR-DOI prototypes is evaluated according to the parameters used in common protocols to test DOI systems particularly basic instrumental performance (BIP). In addition, the potential features of SPADs and SiPMs to improve TR-DOI systems and expand their applications in the foreseeable future are discussed. Lastly, research challenges and future developments for TR-DOI are discussed for each component in the prototype separately and also for the entire system.

A Compact Low-Power Driver Array for VCSELs in 65-nm CMOS Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeng, Zhiyao; Sun, Kexu; Wang, Guanhua

This article presents a compact low-power 4 x 10 Gb/s quad-driver module for Vertical-Cavity Surface-Emitting Laser (VCSEL) arrays in a 65 nm CMOS technology. The side-by-side drivers can be directly wire bonded to the VCSEL diode array, supporting up to 4 channels. To increase the bandwidth of the driver, an internal feed-forward path is added for pole-zero cancellation, without increasing the power consumption. An edge-configurable pre-emphasis technique is proposed to achieve high bandwidth and minimize the asymmetry of the fall and rise times of the driver output current. Measurement results demonstrate a RMS jitter of 0.68 ps for 10 Gb/smore » operation. Tests demonstrate negligible crosstalk between channels. Under irradiation, the modulation amplitude degrades less than 5% up to 300 Mrad ionizing dose. Finally, the area of the quaddriver array is 500 μm by 1000 μm and the total power consumption for the entire driver array chip is 130 mW for the typical current setting.« less

Laser-induced forward transfer for printed electronics applications

NASA Astrophysics Data System (ADS)

Fernández-Pradas, J. M.; Sopeña, P.; González-Torres, S.; Arrese, J.; Cirera, A.; Serra, P.

2018-02-01

Laser-induced forward transfer (LIFT) is a printing technique based on the action of a laser pulse that is focused on a thin film of a precursor ink for getting the transfer of a droplet onto a receiver substrate. The experiments presented in this article aim to demonstrate the ability of LIFT to produce electronic circuits on paper, a substrate that is flexible, cheap and recyclable. Tests were conducted to study the printing of conductive tracks with an Ag ink. The printing of a suspension of carbon nanofibers was also studied to demonstrate the ability of LIFT for printing inks with particles with some microns in size that provoke inkjet nozzles to clog. As a proof-of-concept of the LIFT possibilities, both inks were used to print entirely by LIFT a functional humidity sensor on a piece of paper. All the LIFT experiments were performed with a Nd:YAG laser that delivers pulses of a few hundreds of ns in an attempt to approach the technique to laser systems that are already introduced in many production lines for marking and labeling.

Computational tools and resources for metabolism-related property predictions. 1. Overview of publicly available (free and commercial) databases and software

PubMed Central

Peach, Megan L; Zakharov, Alexey V; Liu, Ruifeng; Pugliese, Angelo; Tawa, Gregory; Wallqvist, Anders; Nicklaus, Marc C

2014-01-01

Metabolism has been identified as a defining factor in drug development success or failure because of its impact on many aspects of drug pharmacology, including bioavailability, half-life and toxicity. In this article, we provide an outline and descriptions of the resources for metabolism-related property predictions that are currently either freely or commercially available to the public. These resources include databases with data on, and software for prediction of, several end points: metabolite formation, sites of metabolic transformation, binding to metabolizing enzymes and metabolic stability. We attempt to place each tool in historical context and describe, wherever possible, the data it was based on. For predictions of interactions with metabolizing enzymes, we show a typical set of results for a small test set of compounds. Our aim is to give a clear overview of the areas and aspects of metabolism prediction in which the currently available resources are useful and accurate, and the areas in which they are inadequate or missing entirely. PMID:23088273

[Adrenal tumours in childhood].

PubMed

Martos-Moreno, G A; Pozo-Román, J; Argente, J

2013-09-01

This special article aims to summarise the current knowledge regarding the two groups of tumours with their origin in the adrenal gland: 1) adrenocortical tumours, derived from the cortex of the adrenal gland and 2) phaeochromocytomas and paragangliomas, neuroendocrine tumours derived from nodes of neural crest derived cells symmetrically distributed at both sides of the entire spine (paragangliomas [PG]). These PGs can be functioning tumors that secrete catecholamines, which confers their typical dark colour after staining with chromium salts (chromaffin tumors). Among these, the term phaeochromocytoma (PC) is restricted to those PGs derived from the chromaffin cells in the adrenal medulla (intra-adrenal PGs), whereas the term PG is used for those sympathetic or parasympathetic ones in an extra-adrenal location. We analyse the state of the art of their pathogenic and genetic bases, as well as their clinical signs and symptoms, the tests currently available for performing their diagnosis (biochemical, hormonal, imaging and molecular studies) and management (surgery, pre- and post-surgical medical treatment), considering the current and developing strategies in chemo- and radiotherapy. Copyright © 2013 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

A Compact Low-Power Driver Array for VCSELs in 65-nm CMOS Technology

DOE PAGES

Zeng, Zhiyao; Sun, Kexu; Wang, Guanhua; ...

2017-05-08

This article presents a compact low-power 4 x 10 Gb/s quad-driver module for Vertical-Cavity Surface-Emitting Laser (VCSEL) arrays in a 65 nm CMOS technology. The side-by-side drivers can be directly wire bonded to the VCSEL diode array, supporting up to 4 channels. To increase the bandwidth of the driver, an internal feed-forward path is added for pole-zero cancellation, without increasing the power consumption. An edge-configurable pre-emphasis technique is proposed to achieve high bandwidth and minimize the asymmetry of the fall and rise times of the driver output current. Measurement results demonstrate a RMS jitter of 0.68 ps for 10 Gb/smore » operation. Tests demonstrate negligible crosstalk between channels. Under irradiation, the modulation amplitude degrades less than 5% up to 300 Mrad ionizing dose. Finally, the area of the quaddriver array is 500 μm by 1000 μm and the total power consumption for the entire driver array chip is 130 mW for the typical current setting.« less

Tissue Engineering and Regenerative Medicine 2015: A Year in Review

PubMed Central

Wobma, Holly

2016-01-01

This may be the most exciting time ever for the field of tissue engineering and regenerative medicine (TERM). After decades of progress, it has matured, integrated, and diversified into entirely new areas, and it is starting to make the pivotal shift toward translation. The most exciting science and applications continue to emerge at the boundaries of disciplines, through increasingly effective interactions between stem cell biologists, bioengineers, clinicians, and the commercial sector. In this “Year in Review,” we highlight some of the major advances reported over the last year (Summer 2014–Fall 2015). Using a methodology similar to that established in previous years, we identified four areas that generated major progress in the field: (i) pluripotent stem cells, (ii) microtissue platforms for drug testing and disease modeling, (iii) tissue models of cancer, and (iv) whole organ engineering. For each area, we used some of the most impactful articles to illustrate the important concepts and results that advanced the state of the art of TERM. We conclude with reflections on emerging areas and perspectives for future development in the field. PMID:26714410

JPRS Report, West Europe.

DTIC Science & Technology

1987-07-20

original 4 - 5 million. The entire loan episode is seen today as an unfortunate adventure which caused a lot of confusion and resulted in a loss of...Today’s "Model 4 " must be modified. It can be stated with certainty even now that upon completion of the reforms and new directives the ...Stockholm MARIN NYTT in Swedish No 2, 1987 pp 4 - 5 [Article by Torbjorn Hultman of the FMW] [Text] Sonar systems are hydroacoustic search systems

IIT Kharagpur at TREC 2008 Blog Track

DTIC Science & Technology

2008-10-25

blog) examples. Each one is the entire HTML content of 2 Title: iFractal: Steve Jobs Keynote at Macworld: Black T-Shirt, Jeans, and a Lot of...Preparation Post: Steve Jobs Keynote at Macworld: Black T-Shirt, Jeans, and a Lot of Preparation. Scott McNulty at TUAW pointed me to Behind the Magic Curtain...which is about how Steve Jobs is preparing for his keynote speech at Macworld Expo next week in San Francisco. From the article: When Apple

Air and Space Power Journal. Volume 25, Number 2, Summer 2011

DTIC Science & Technology

2011-01-01

their entire life cycles. The EIO- LCA results give Air Force leaders a basis for evaluating alternative ways of implementing the ser- vice’s energy...strategy. Background Before presenting and discussing the EIO- LCA results , the article addresses envi- ronmental concerns associated with burning fuel...to the EIO- LCA model results , the GWP for the CBTL fuel was 14 percent less than that for the JP-8 fuel, not considering car- bon capture. In other

Extra-bodily DNA sampling by the police.

PubMed

Gans, Jeremy

2013-12-01

Forensic investigators have statutory powers to take DNA samples directly from suspects' bodies in certain circumstances but sometimes the powers fall short, legally or practically Police may then look for samples that have become separated from their suspects for one reason or another. No jurisdiction currently bars or even regulates this practice, which is instead loosely governed by laws on property, consent and evidence. This article argues that this lack of regulation undermines the entire system of forensic procedure laws.

Resilient Airmen: Pacific Air Forces’ Critical Enabler

DTIC Science & Technology

2015-02-01

VIEWS T he sun never sets on Pacific Air Forces (PACAF). From Alaska to Antarctica and from California to India, PACAF’s area of re- sponsibility...and defend US interests. This article not only addresses the meaning of resiliency but also-and more importantly-examines why it is critical to...it demonstrates how the RA LOO is part of larger, strategic game plan to inject resiliency into our entire force structure as a means of fulfilling

1942

NASA Astrophysics Data System (ADS)

Williams, Kathryn R.

1999-08-01

Since The Journal's inception in 1924, almost every issue has contained at least one article relating to the history of chemistry. But JCE should not be overlooked as a source for social and political history. At no time did the Journal better serve as a mirror of society than during the World War II era. This month's look at the past focusses on volume 19 (1942), which illustrates the response of the entire nation, especially colleges and universities, to the attack on Pearl Harbor.

Satellite Power Systems (SPS). LSST systems and integration task for SPS flight test article

NASA Technical Reports Server (NTRS)

Greenberg, H. S.

1981-01-01

This research activity emphasizes the systems definition and resulting structural requirements for the primary structure of two potential SPS large space structure test articles. These test articles represent potential steps in the SPS research and technology development.

3D bioprint me: a socioethical view of bioprinting human organs and tissues

PubMed Central

Vermeulen, Niki; Haddow, Gill; Seymour, Tirion; Faulkner-Jones, Alan; Shu, Wenmiao

2017-01-01

In this article, we review the extant social science and ethical literature on three-dimensional (3D) bioprinting. 3D bioprinting has the potential to be a ‘game-changer’, printing human organs on demand, no longer necessitating the need for living or deceased human donation or animal transplantation. Although the technology is not yet at the level required to bioprint an entire organ, 3D bioprinting may have a variety of other mid-term and short-term benefits that also have positive ethical consequences, for example, creating alternatives to animal testing, filling a therapeutic need for minors and avoiding species boundary crossing. Despite a lack of current socioethical engagement with the consequences of the technology, we outline what we see as some preliminary practical, ethical and regulatory issues that need tackling. These relate to managing public expectations and the continuing reliance on technoscientific solutions to diseases that affect high-income countries. Avoiding prescribing a course of action for the way forward in terms of research agendas, we do briefly outline one possible ethical framework ‘Responsible Research Innovation’ as an oversight model should 3D bioprinting promises are ever realised. 3D bioprinting has a lot to offer in the course of time should it move beyond a conceptual therapy, but is an area that requires ethical oversight and regulation and debate, in the here and now. The purpose of this article is to begin that discussion. PMID:28320774

40 CFR 86.161-00 - Air conditioning environmental test facility ambient requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... each point of a 0.5 meter grid over the entire footprint of the test vehicle at the elevation of one... impractical, air flow of 2 mph or less will be allowed at 0 mph vehicle speed. (3) The fan air flow velocity..., within the test cell, during all phases of the air conditioning test sequence to 95 ±2 °F on average and...

The Effect of Radiation on Selected Photographic Film

NASA Technical Reports Server (NTRS)

Slater, Richard; Kinard, John; Firsov, Ivan

2000-01-01

We conducted this film test to evaluate several manufacturers' photographic films for their ability to acquire imagery on the International Space Station. We selected 25 motion picture, photographic slide, and negative films from three different film manufacturers. We based this selection on the fact that their films ranked highest in other similar film tests, and on their general acceptance by the international community. This test differed from previous tests because the entire evaluation process leading up to the final selection was based on information derived after the original flight film was scanned to a digital file. Previously conducted tests were evaluated entirely based on 8 x 10s that were produced from the film either directly or through the internegative process. This new evaluation procedure provided accurate quantitative data on granularity and contrast from the digital data. This test did not try to define which film was best visually. This is too often based on personal preference. However, the test results did group the films by good, marginal, and unacceptable. We developed, and included in this report, a template containing quantitative, graphical, and visual information for each film. These templates should be sufficient for comparing the different films tested and subsequently selecting a film or films to be used for experiments and general documentation on the International Space Station.

Testing and inspecting lens by holographic means

DOEpatents

Hildebrand, Bernard P.

1976-01-01

Processes for the accurate, rapid and inexpensive testing and inspecting of oncave and convex lens surfaces through holographic means requiring no beamsplitters, mirrors or overpower optics, and wherein a hologram formed in accordance with one aspect of the invention contains the entire interferometer and serves as both a master and illuminating source for both concave and said convex surfaces to be so tested.

Immediate vs. Delayed Feedback in a Computer-Managed Test: Effects on Long-Term Retention. Technical Report, March 1976-August 1976.

ERIC Educational Resources Information Center

Sturges, Persis T.

This experiment was designed to test the effect of immediate and delayed feedback on retention of learning in an educational situation. Four groups of college undergraduates took a multiple-choice computer-managed test. Three of these groups received informative feedback (the entire item with the correct answer identified) either: (1) immediately…

49 CFR Appendix D to Part 173 - Test Methods for Dynamite (Explosive, Blasting, Type A)

Code of Federal Regulations, 2011 CFR

2011-10-01

... weighed to determine the percent of weight loss. 3. Test method D-3—Compression Exudation Test The entire... from the glass tube and weighed to determine the percent of weight loss. EC02MR91.067 ... assembly is placed under the compression rod, and compression is applied by means of the weight on the...

A Duplicate Construction Experiment.

ERIC Educational Resources Information Center

Bridgeman, Brent

This experiment was designed to assess the ability of item writers to construct truly parallel tests based on a "duplicate-construction experiment" in which Cronbach argues that if the universe description and sampling are ideally refined, the two independently constructed tests will be entirely equivalent, and that within the limits of item…

40 CFR 258.41 - Project XL Bioreactor Landfill Projects.

Code of Federal Regulations, 2012 CFR

2012-07-01

... using the Standard Test Method for Measuring Mass per Unit Area of Geotextiles, ASTM D-5261-92... determined by the Standard Test Method for Laboratory Determination of Water (Moisture) Content of Soil and... with the provisions of the FESOP, during the entire period of leachate recirculation and the post...

40 CFR 258.41 - Project XL Bioreactor Landfill Projects.

Code of Federal Regulations, 2011 CFR

2011-07-01

... using the Standard Test Method for Measuring Mass per Unit Area of Geotextiles, ASTM D-5261-92... determined by the Standard Test Method for Laboratory Determination of Water (Moisture) Content of Soil and... with the provisions of the FESOP, during the entire period of leachate recirculation and the post...

40 CFR 258.41 - Project XL Bioreactor Landfill Projects.

Code of Federal Regulations, 2013 CFR

2013-07-01

... using the Standard Test Method for Measuring Mass per Unit Area of Geotextiles, ASTM D-5261-92... determined by the Standard Test Method for Laboratory Determination of Water (Moisture) Content of Soil and... with the provisions of the FESOP, during the entire period of leachate recirculation and the post...

USING PARTIAL LEAST SQUARES REGRESSION TO OBTAIN COTTON FIBER LENGTH DISTRIBUTIONS FROM THE BEARD TESTING METHOD

USDA-ARS?s Scientific Manuscript database

The beard testing method for measuring cotton fiber length is based on the fibrogram theory. However, in the instrumental implementations, the engineering complexity alters the original fiber length distribution observed by the instrument. This causes challenges in obtaining the entire original le...

Secondary and 2-Year Outcomes of a Sexual Assault Resistance Program for University Women

PubMed Central

Eliasziw, Misha; Hobden, Karen L.; Newby-Clark, Ian R.; Barata, Paula C.; Radtke, H. Lorraine; Thurston, Wilfreda E.

2017-01-01

We report the secondary outcomes and longevity of efficacy from a randomized controlled trial that evaluated a novel sexual assault resistance program designed for first-year women university students. Participants (N = 893) were randomly assigned to receive the Enhanced Assess, Acknowledge, Act (EAAA) program or a selection of brochures (control). Perception of personal risk, self-defense self-efficacy, and rape myth acceptance was assessed at baseline; 1-week postintervention; and 6-, 12-, 18-, and 24-month postrandomization. Risk detection was assessed at 1 week, 6 months, and 12 months. Sexual assault experience and knowledge of effective resistance strategies were assessed at all follow-ups. The EAAA program produced significant increases in women’s perception of personal risk, self-defense self-efficacy, and knowledge of effective (forceful verbal and physical) resistance strategies; the program also produced decreases in general rape myth acceptance and woman blaming over the entire 24-month follow-up period. Risk detection was significantly improved for the intervention group at post-test. The program significantly reduced the risk of completed and attempted rape, attempted coercion, and nonconsensual sexual contact over the entire follow-up period, yielding reductions between 30% and 64% at 2 years. The EAAA program produces long-lasting changes in secondary outcomes and in the incidence of sexual assault experienced by women students. Universities can reduce the harm and the negative health consequences that young women experience as a result of campus sexual assault by implementing this program. Online slides for instructors who want to use this article for teaching are available on PWQ’s website at http://journals.sagepub.com/page/pwq/suppl/index. PMID:29503496

Secondary and 2-Year Outcomes of a Sexual Assault Resistance Program for University Women.

PubMed

Senn, Charlene Y; Eliasziw, Misha; Hobden, Karen L; Newby-Clark, Ian R; Barata, Paula C; Radtke, H Lorraine; Thurston, Wilfreda E

2017-06-01

We report the secondary outcomes and longevity of efficacy from a randomized controlled trial that evaluated a novel sexual assault resistance program designed for first-year women university students. Participants ( N = 893) were randomly assigned to receive the Enhanced Assess, Acknowledge, Act (EAAA) program or a selection of brochures (control). Perception of personal risk, self-defense self-efficacy, and rape myth acceptance was assessed at baseline; 1-week postintervention; and 6-, 12-, 18-, and 24-month postrandomization. Risk detection was assessed at 1 week, 6 months, and 12 months. Sexual assault experience and knowledge of effective resistance strategies were assessed at all follow-ups. The EAAA program produced significant increases in women's perception of personal risk, self-defense self-efficacy, and knowledge of effective (forceful verbal and physical) resistance strategies; the program also produced decreases in general rape myth acceptance and woman blaming over the entire 24-month follow-up period. Risk detection was significantly improved for the intervention group at post-test. The program significantly reduced the risk of completed and attempted rape, attempted coercion, and nonconsensual sexual contact over the entire follow-up period, yielding reductions between 30% and 64% at 2 years. The EAAA program produces long-lasting changes in secondary outcomes and in the incidence of sexual assault experienced by women students. Universities can reduce the harm and the negative health consequences that young women experience as a result of campus sexual assault by implementing this program. Online slides for instructors who want to use this article for teaching are available on PWQ's website at http://journals.sagepub.com/page/pwq/suppl/index .

Payload test philosophy. [implications of STS development at Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Arman, A.

1979-01-01

The implications of STS development for payload testing at the Goddard Space Flight Center are reviewed. The biggest impact of STS may be that instead of testing the entire payload, most of the testing may have to be limited to the subsystem or subassembly level. Particular consideration is given to the Goddard protoflight concept in which the test is geared to the design qualification levels, the test durations being those that are expected during the actual launch sequence.

Hydrologeology and water quality of the Floridan aquifer system and effect of Lower Floridan aquifer pumping on the Upper Floridan aquifer, Pooler, Chatham County, Georgia, 2011–2012

USGS Publications Warehouse

Gonthier, Gerard

2012-01-01

Two test wells were completed in Pooler, Georgia, in 2011 to investigate the potential of using the Lower Floridan aquifer as a source of water for municipal use. One well was completed in the Lower Floridan aquifer at a depth of 1,120 feet (ft) below land surface; the other well was completed in the Upper Floridan aquifer at a depth of 486 ft below land surface. At the Pooler test site, the U.S. Geological Survey performed flowmeter surveys, packer-isolated slug tests within the Lower Floridan confining unit, slug tests of the entire Floridan aquifer system, and aquifer tests of the Upper and Lower Floridan aquifers. Drill cuttings, geophysical logs, and borehole flowmeter surveys indicate that the Upper Floridan aquifer extends 333 –515 ft below land surface, the Lower Floridan confining unit extends 515–702 ft below land surface, and the Lower Floridan aquifer extends 702–1,040 ft below land surface. Flowmeter surveys indicate that the Upper Floridan aquifer contains two water-bearing zones at depth intervals of 339 –350 and 375–515 ft; the Lower Floridan confining unit contains one zone at a depth interval of 550–620 ft; and the Lower Floridan aquifer contains five zones at depth intervals of 702–745, 745–925, 925–984, 984–1,015, and 1,015–1,040 ft. Flowmeter testing of the test borehole open to the entire Floridan aquifer system indicated that the Upper Floridan aquifer contributed 92.4 percent of the total flow rate of 708 gallons per minute; the Lower Floridan confining unit contributed 3.0 percent; and the Lower Floridan aquifer contributed 4.6 percent. Horizontal hydraulic conductivity of the Lower Floridan confining unit derived from slug tests within three packer-isolated intervals ranged from 0.5 to 10 feet per day (ft/d). Aquifer-test analyses yielded values of transmissivity for the Upper Floridan aquifer, Lower Floridan confining unit, and the Lower Floridan aquifer of 46,000, 700, and 4,000 feet squared per day (ft2/d), respectively. Horizontal hydraulic conductivity of 4 ft/d for the Lower Floridan confining unit, derived from aquifer-test analyses, is near the midrange for values derived from packer-isolated slug tests. The transmissivity of the entire Floridan aquifer system derived from aquifer-test analyses totals about 51,000 ft2/d, similar to the value of 58,000 ft2/d derived from open slug tests on the entire Floridan aquifer system. Water-level data for each aquifer test were filtered for external influences such as barometric pressure, earth-tide effects, and long-term trends to enable detection of small (less than 1 foot) water-level responses to aquifer-test pumping. During the 72-hour aquifer test of pumping the Lower Floridan aquifer, a drawdown response of 51.7 ft was observed in the Lower Floridan pumped well and a drawdown response of 0.9 foot was observed in the Upper Floridan observation well located 85 ft from the pumped well.

48 CFR 9.308-2 - Testing performed by the Government.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.308-2 Testing performed by... produce the first article and the production quantity at the same facility, the contracting officer shall... purchase material or to commence production before first article approval, the contracting officer shall...

48 CFR 9.308-2 - Testing performed by the Government.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.308-2 Testing performed by... produce the first article and the production quantity at the same facility, the contracting officer shall... purchase material or to commence production before first article approval, the contracting officer shall...

48 CFR 9.308-2 - Testing performed by the Government.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.308-2 Testing performed by... produce the first article and the production quantity at the same facility, the contracting officer shall... purchase material or to commence production before first article approval, the contracting officer shall...

48 CFR 9.308-2 - Testing performed by the Government.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.308-2 Testing performed by... produce the first article and the production quantity at the same facility, the contracting officer shall... purchase material or to commence production before first article approval, the contracting officer shall...

48 CFR 9.308-2 - Testing performed by the Government.

Code of Federal Regulations, 2013 CFR

2013-10-01

... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.308-2 Testing performed by... produce the first article and the production quantity at the same facility, the contracting officer shall... purchase material or to commence production before first article approval, the contracting officer shall...

How the structure of Wikipedia articles influences user navigation.

PubMed

Lamprecht, Daniel; Lerman, Kristina; Helic, Denis; Strohmaier, Markus

2017-01-02

In this work we study how people navigate the information network of Wikipedia and investigate (i) free-form navigation by studying all clicks within the English Wikipedia over an entire month and (ii) goal-directed Wikipedia navigation by analyzing wikigames, where users are challenged to retrieve articles by following links. To study how the organization of Wikipedia articles in terms of layout and links affects navigation behavior, we first investigate the characteristics of the structural organization and of hyperlinks in Wikipedia and then evaluate link selection models based on article structure and other potential influences in navigation, such as the generality of an article's topic. In free-form Wikipedia navigation, covering all Wikipedia usage scenarios, we find that click choices can be best modeled by a bias towards article structure, such as a tendency to click links located in the lead section. For the goal-directed navigation of wikigames, our findings confirm the zoom-out and the homing-in phases identified by previous work, where users are guided by generality at first and textual similarity to the target later. However, our interpretation of the link selection models accentuates that article structure is the best explanation for the navigation paths in all except these initial and final stages. Overall, we find evidence that users more frequently click on links that are located close to the top of an article. The structure of Wikipedia articles, which places links to more general concepts near the top, supports navigation by allowing users to quickly find the better-connected articles that facilitate navigation. Our results highlight the importance of article structure and link position in Wikipedia navigation and suggest that better organization of information can help make information networks more navigable.

How the structure of Wikipedia articles influences user navigation

NASA Astrophysics Data System (ADS)

Lamprecht, Daniel; Lerman, Kristina; Helic, Denis; Strohmaier, Markus

2017-01-01

In this work we study how people navigate the information network of Wikipedia and investigate (i) free-form navigation by studying all clicks within the English Wikipedia over an entire month and (ii) goal-directed Wikipedia navigation by analyzing wikigames, where users are challenged to retrieve articles by following links. To study how the organization of Wikipedia articles in terms of layout and links affects navigation behavior, we first investigate the characteristics of the structural organization and of hyperlinks in Wikipedia and then evaluate link selection models based on article structure and other potential influences in navigation, such as the generality of an article's topic. In free-form Wikipedia navigation, covering all Wikipedia usage scenarios, we find that click choices can be best modeled by a bias towards article structure, such as a tendency to click links located in the lead section. For the goal-directed navigation of wikigames, our findings confirm the zoom-out and the homing-in phases identified by previous work, where users are guided by generality at first and textual similarity to the target later. However, our interpretation of the link selection models accentuates that article structure is the best explanation for the navigation paths in all except these initial and final stages. Overall, we find evidence that users more frequently click on links that are located close to the top of an article. The structure of Wikipedia articles, which places links to more general concepts near the top, supports navigation by allowing users to quickly find the better-connected articles that facilitate navigation. Our results highlight the importance of article structure and link position in Wikipedia navigation and suggest that better organization of information can help make information networks more navigable.

How the structure of Wikipedia articles influences user navigation

PubMed Central

Lamprecht, Daniel; Lerman, Kristina; Helic, Denis; Strohmaier, Markus

2017-01-01

In this work we study how people navigate the information network of Wikipedia and investigate (i) free-form navigation by studying all clicks within the English Wikipedia over an entire month and (ii) goal-directed Wikipedia navigation by analyzing wikigames, where users are challenged to retrieve articles by following links. To study how the organization of Wikipedia articles in terms of layout and links affects navigation behavior, we first investigate the characteristics of the structural organization and of hyperlinks in Wikipedia and then evaluate link selection models based on article structure and other potential influences in navigation, such as the generality of an article's topic. In free-form Wikipedia navigation, covering all Wikipedia usage scenarios, we find that click choices can be best modeled by a bias towards article structure, such as a tendency to click links located in the lead section. For the goal-directed navigation of wikigames, our findings confirm the zoom-out and the homing-in phases identified by previous work, where users are guided by generality at first and textual similarity to the target later. However, our interpretation of the link selection models accentuates that article structure is the best explanation for the navigation paths in all except these initial and final stages. Overall, we find evidence that users more frequently click on links that are located close to the top of an article. The structure of Wikipedia articles, which places links to more general concepts near the top, supports navigation by allowing users to quickly find the better-connected articles that facilitate navigation. Our results highlight the importance of article structure and link position in Wikipedia navigation and suggest that better organization of information can help make information networks more navigable. PMID:28670171

Hot-Fire Test Results of Liquid Oxygen/RP-2 Multi-Element Oxidizer-Rich Preburners

NASA Technical Reports Server (NTRS)

Protz, C. S.; Garcia, C. P.; Casiano, M. J.; Parton, J. A.; Hulka, J. R.

2016-01-01

As part of the Combustion Stability Tool Development project funded by the Air Force Space and Missile Systems Center, the NASA Marshall Space Flight Center was contracted to assemble and hot-fire test a multi-element integrated test article demonstrating combustion characteristics of an oxygen/hydrocarbon propellant oxidizer-rich staged-combustion engine thrust chamber. Such a test article simulates flow through the main injectors of oxygen/kerosene oxidizer-rich staged combustion engines such as the Russian RD-180 or NK-33 engines, or future U.S.-built engine systems such as the Aerojet-Rocketdyne AR-1 engine or the Hydrocarbon Boost program demonstration engine. To supply the oxidizer-rich combustion products to the main injector of the integrated test article, existing subscale preburner injectors from a previous NASA-funded oxidizer-rich staged combustion engine development program were utilized. For the integrated test article, existing and newly designed and fabricated inter-connecting hot gas duct hardware were used to supply the oxidizer-rich combustion products to the oxidizer circuit of the main injector of the thrust chamber. However, before one of the preburners was used in the integrated test article, it was first hot-fire tested at length to prove it could provide the hot exhaust gas mean temperature, thermal uniformity and combustion stability necessary to perform in the integrated test article experiment. This paper presents results from hot-fire testing of several preburner injectors in a representative combustion chamber with a sonic throat. Hydraulic, combustion performance, exhaust gas thermal uniformity, and combustion stability data are presented. Results from combustion stability modeling of these test results are described in a companion paper at this JANNAF conference, while hot-fire test results of the preburner injector in the integrated test article are described in another companion paper.

14 CFR 35.33 - General.

Code of Federal Regulations, 2010 CFR

2010-01-01

... STANDARDS: PROPELLERS Tests and Inspections § 35.33 General. (a) Each applicant must furnish test article(s... nature of the test. If needed for substantiation, the applicant may test a different propeller...

14 CFR 35.33 - General.

Code of Federal Regulations, 2011 CFR

2011-01-01

... STANDARDS: PROPELLERS Tests and Inspections § 35.33 General. (a) Each applicant must furnish test article(s... nature of the test. If needed for substantiation, the applicant may test a different propeller...

14 CFR 35.33 - General.

Code of Federal Regulations, 2014 CFR

2014-01-01

... STANDARDS: PROPELLERS Tests and Inspections § 35.33 General. (a) Each applicant must furnish test article(s... nature of the test. If needed for substantiation, the applicant may test a different propeller...

14 CFR 35.33 - General.

Code of Federal Regulations, 2012 CFR

2012-01-01

... STANDARDS: PROPELLERS Tests and Inspections § 35.33 General. (a) Each applicant must furnish test article(s... nature of the test. If needed for substantiation, the applicant may test a different propeller...

14 CFR 35.33 - General.

Code of Federal Regulations, 2013 CFR

2013-01-01

... STANDARDS: PROPELLERS Tests and Inspections § 35.33 General. (a) Each applicant must furnish test article(s... nature of the test. If needed for substantiation, the applicant may test a different propeller...

Prototype space erectable radiator system ground test article development

NASA Technical Reports Server (NTRS)

Alario, Joseph P.

1988-01-01

A prototype heat rejecting system is being developed by NASA-JSC for possible space station applications. This modular system, the Space-Erectable Radiator System Ground Test Article (SERS-GTA) with high-capacity radiator panels, can be installed and replaced on-orbit. The design, fabrication and testing of a representative ground test article are discussed. Acceptance test data for the heat pipe radiator panel and the whiffletree clamping mechanism have been presented.

48 CFR 9.308-1 - Testing performed by the contractor.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.308-1 Testing performed by... produce the first article and the production quantity at the same facility, the contracting officer shall... material or to commence production before first article approval, the contracting officer shall use the...

48 CFR 9.308-1 - Testing performed by the contractor.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.308-1 Testing performed by... produce the first article and the production quantity at the same facility, the contracting officer shall... material or to commence production before first article approval, the contracting officer shall use the...

48 CFR 9.308-1 - Testing performed by the contractor.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.308-1 Testing performed by... produce the first article and the production quantity at the same facility, the contracting officer shall... material or to commence production before first article approval, the contracting officer shall use the...

48 CFR 9.308-1 - Testing performed by the contractor.

Code of Federal Regulations, 2013 CFR

2013-10-01

... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.308-1 Testing performed by... produce the first article and the production quantity at the same facility, the contracting officer shall... material or to commence production before first article approval, the contracting officer shall use the...

48 CFR 9.308-1 - Testing performed by the contractor.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ACQUISITION PLANNING CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.308-1 Testing performed by... produce the first article and the production quantity at the same facility, the contracting officer shall... material or to commence production before first article approval, the contracting officer shall use the...

Testing in Texas: Accountability for Bilingual Students.

ERIC Educational Resources Information Center

Porter, Rosalie Pedalino, Ed.

2000-01-01

This issue has a special, multi-article section on student testing in Texas and contains three additional and unrelated articles. "The Texas Testing Case Documents: G.I. Forum, et al. v. Texas Education Agency, et al." section has five articles: "Overview" (Roger Clegg); a copy of the "First Amended Complaint";…

Analysis of power gating in different hierarchical levels of 2MB cache, considering variation

NASA Astrophysics Data System (ADS)

Jafari, Mohsen; Imani, Mohsen; Fathipour, Morteza

2015-09-01

This article reintroduces power gating technique in different hierarchical levels of static random-access memory (SRAM) design including cell, row, bank and entire cache memory in 16 nm Fin field effect transistor. Different structures of SRAM cells such as 6T, 8T, 9T and 10T are used in design of 2MB cache memory. The power reduction of the entire cache memory employing cell-level optimisation is 99.7% with the expense of area and other stability overheads. The power saving of the cell-level optimisation is 3× (1.2×) higher than power gating in cache (bank) level due to its superior selectivity. The access delay times are allowed to increase by 4% in the same energy delay product to achieve the best power reduction for each supply voltages and optimisation levels. The results show the row-level power gating is the best for optimising the power of the entire cache with lowest drawbacks. Comparisons of cells show that the cells whose bodies have higher power consumption are the best candidates for power gating technique in row-level optimisation. The technique has the lowest percentage of saving in minimum energy point (MEP) of the design. The power gating also improves the variation of power in all structures by at least 70%.

Subgroup conflicts? Try the psychodramatic "double triad method".

PubMed

Verhofstadt-Denève, Leni M F

2012-04-01

The present article suggests the application of a psychodramatic action method for tackling subgroup conflicts in which the direct dialogue between representatives of two opposing subgroups is prepared step by step through an indirect dialogue strategy within two triads, a strategy known as the Double Triad Method (DTM). In order to achieve integration in the group as a whole, it is important that all the members of both subgroups participate actively during the entire process. The first part of the article briefly explores the theoretical background, with a special emphasis on the Phenomenological-Dialectical Personality Model (Phe-Di PModel). In the second part, the DTM procedure is systematically described through its five action stages, each accompanied with 1) a spatial representation of the consecutive actions, 2) some illustrative statements for each stage, and 3) a theoretical interpretation of the dialectically involved personality dimensions in both protagonists. The article concludes with a discussion and suggestions for more extensive applications of the DTM method, including the question of its relationships to Agazarian's functional subgrouping, psychodrama, and sociodrama.

Natural medicaments in dentistry

PubMed Central

Sinha, Dakshita J.; Sinha, Ashish A.

2014-01-01

The major objective in root canal treatment is to disinfect the entire root canal system. Cleaning, shaping, and use of antimicrobial medicaments are effective in reducing the bacterial load to some extent, but some bacteria do remain behind and multiply, causing reinfection. Taking into consideration the ineffectiveness, potential side-effects and safety concerns of synthetic drugs, the herbal alternatives for endodontic usage might prove to be advantageous. Over the past decade, interest in drugs derived from medicinal plants has markedly increased. Phytomedicine has been used in dentistry as anti-inflammatory, antibiotic, analgesic, sedative and also as endodontic irrigant. Herbal preparations can be derived from the root, leaves, seeds, stem, and flowers. The PubMed database search revealed that the reference list for natural medicaments featured 1480 articles and in dentistry 173 articles. A forward search was undertaken on the selected articles and author names. This review focuses on various natural drugs and products as well as their therapeutic applications when used as phytomedicine in dentistry. PMID:25558153

Orbiter Enterprise at Marshall Space Flight Center for testing

NASA Image and Video Library

2002-10-29

In this view, the Shuttle Orbiter Enterprise is seen heading South on Rideout Road with Marshall Space Flight Center's (MSFC'S) administrative 4200 Complex in the background, as it is being transported to MSFC's building 4755 for later Mated Vertical Ground Vibration tests (MVGVT) at MSFC's Dynamic Test Stand. The tests marked the first time ever that the entire shuttle complement (including Orbiter, external tank, and solid rocket boosters) were mated vertically.

Design and Analysis of Subscale and Full-Scale Buckling-Critical Cylinders for Launch Vehicle Technology Development

NASA Technical Reports Server (NTRS)

Hilburger, Mark W.; Lovejoy, Andrew E.; Thornburgh, Robert P.; Rankin, Charles

2012-01-01

NASA s Shell Buckling Knockdown Factor (SBKF) project has the goal of developing new analysis-based shell buckling design factors (knockdown factors) and design and analysis technologies for launch vehicle structures. Preliminary design studies indicate that implementation of these new knockdown factors can enable significant reductions in mass and mass-growth in these vehicles. However, in order to validate any new analysis-based design data or methods, a series of carefully designed and executed structural tests are required at both the subscale and full-scale levels. This paper describes the design and analysis of three different orthogrid-stiffeNed metallic cylindrical-shell test articles. Two of the test articles are 8-ft-diameter, 6-ft-long test articles, and one test article is a 27.5-ft-diameter, 20-ft-long Space Shuttle External Tank-derived test article.

["... here I am entirely among patients now..": the psychoanalytical practice of Lou Andreas-Salomé].

PubMed

Klemann, Manfred

2005-01-01

The aim of this article is to disprove the widespread prejudice depicting Andreas-Salomé merely as a femme fatale, or companion of a few famous contemporaries (Nietzsche, Rilke, and Freud), while suppressing her original intellectual and clinical-practical achievement as a psychoanalyst. An evaluation of both published and hitherto unpublished sources clearly confirms the broad and thorough foundations of her psychoanalytical training in theory as well as in practice. Between 1913 and 1933 Andreas-Salomé conducted a relatively large number of analyses, discussed some of them with Freud in a kind of "supervision" by correspondence and published several articles on central psychoanalytical issues. So far, however, many psychoanalysts seem to have been unaware of her status as a former accomplished colleague.