Colorado Children's Budget 2011

ERIC Educational Resources Information Center

Colorado Children's Campaign, 2011

2011-01-01

"Colorado Children's Budget 2011" tallies up Colorado's public investments during FY 2007-08 through FY 2011-12 for programs and services that enhance the well-being of children across four domains--Early Childhood, K-12 Education, Health, and Other Supports. It is intended to be a resource guide for policymakers and advocates who are…

RESULTS OF TRITIUM TRACKING AND GROUNDWATER MONITORING AT THE HANFORD SITE 200 AREA STATE APPROVED LAND DISPOSAL SITE FY2008

DOE Office of Scientific and Technical Information (OSTI.GOV)

ERB DB

2008-11-19

The Hanford Site's 200 Area Effluent Treatment Facility (ETF) processes contaminated aqueous wastes derived from Hanford Site facilities. The treated wastewater occasionally contains tritium, which cannot be removed by the ETF prior to the wastewater being discharged to the 200 Area State-Approved Land Disposal Site (SALDS). During the first 11 months of fiscal year 2008 (FY08) (September 1, 2007, to July 31, 2008), approximately 75.15 million L (19.85 million gal) of water were discharged to the SALDS. Groundwater monitoring for tritium and other constituents, as well as water-level measurements, is required for the SALDS by State Waste Discharge Permit Numbermore » ST-4500 (Ecology 2000). The current monitoring network consists of three proximal (compliance) monitoring wells and nine tritium-tracking wells. Quarterly sampling of the proximal wells occurred in October 2007 and in January/February 2008, April 2008, and August 2008. The nine tritium-tracking wells, including groundwater monitoring wells located upgradient and downgradient of the SALDS, were sampled in January through April 2008. Water-level measurements taken in the three proximal SALDS wells indicate that a small groundwater mound is present beneath the facility, which is a result of operational discharges. The mound increased in FY08 due to increased ETF discharges from treating groundwater from extraction wells at the 200-UP-l Operable Unit and the 241-T Tank Farm. Maximum tritium activities increased by an order of magnitude at well 699-48-77A (to 820,000 pCi/L in April 2008) but remained unchanged in the other two proximal wells. The increase was due to higher quantities of tritium in wastewaters that were treated and discharged in FY07 beginning to appear at the proximal wells. The FY08 tritium activities for the other two proximal wells were 68,000 pCi/L at well 699-48-77C (October 2007) and 120,000 pCi/L at well 699-48-77D (October 2007). To date, no indications of a tritium incursion from the SALDS have been detected in the tritium-tracking wells. Concentrations of all chemical constituents were within Permit limits or were below method detection limits when sampled during FY08. A summary of the chemical constituent concentrations or method detection limits is provided in Table 3-2 in the main text discussion. This report presents the results of groundwater monitoring and tritium-tracking samples from the SALDS facility during FY08. Due to the 30-day laboratory turnaround for analysis of proximal well groundwater samples, this report addresses available date extending from August 1, 2007, through September 30, 2008 (August 2007 data were not included in the FY07 report). Updated background information, which is necessary to understand the results of the groundwater analyses, is also provided on facility operations. Interpretive discussions and recommendations for future monitoring are also provided, where possible.« less

Enhanced surveillance program FY97 accomplishments. Progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mauzy, A.; Laake, B.

1997-10-01

This annual report is one volume of the Enhanced Surveillance Program (ESP) FY97 Accomplishments. The complete accomplishments report consists of 11 volumes. Volume 1 includes an ESP overview and a summary of selected unclassified FY97 program highlights. Volume 1 specifically targets a general audience, reflecting about half of the tasks conducted in FY97 and emphasizing key program accomplishments and contributions. The remaining volumes of the accomplishments report are classified, organized by program focus area, and present in technical detail the progress achieved in each of the 104 FY97 program tasks. Focus areas are as follows: pits; high explosives; organics; dynamics;more » diagnostics; systems; secondaries; nonnuclear materials; nonnuclear components; and Surveillance Test Program upgrades.« less

Coalition Warfare Program Presentation to: 2009 EUCOM/AFRICOM Science and Technology Conference

DTIC Science & Technology

2009-06-01

compac an nexpens ve m cro- fluxgate magnetometer for use in multiple COCOMs. To continue T&E with joint services and apply lessons learned to...Partners in EUCOM/AFRICOM FY08 Starts • Advanced Dynamic Magnetometer FY09 Starts • ADNS Coalition Network FY10 New Starts • Clip-on Night Vision...Partner 2008 New Starts Advanced Dynamic Magnetometer for Static and Moving Applications T d l t d i i i US Navy (SPAWAR) Italy, Sweden o eve op a a

75 FR 8916 - Glenn/Colusa County Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-26

...) Introductions, (2) Approve Minutes, (3) RAC Admin Updates, (4) Public Comment, (5) FY08 and FY09 New Project... National Forest Supervisor's Office, 825 N. Humboldt Ave., Willows, CA 95988. Individuals who wish to speak... . SUPPLEMENTARY INFORMATION: The meeting will be open to the public. Committee discussion is limited to Forest...

75 FR 52771 - Notice of Availability: Notice of Funding Availability (NOFA) for Fiscal Year (FY) 2010 Indian...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-27

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5415-N-08] Notice of Availability: Notice of Funding Availability (NOFA) for Fiscal Year (FY) 2010 Indian Community Development Block Grant... retained to fund Imminent Threat Grants. The purpose of the ICDBG program is the development of viable...

Accelerated Progress Through Self-Determination. Second Annual Report of the Choctaw Self-Determination Project, July 1, 1972 - October 31, 1973.

ERIC Educational Resources Information Center

Mississippi Band of Choctaw Indians, Philadelphia.

Self-determination for the Choctaw tribal government and its people was reflected in the progress made in program development. Programs in effect during fiscal year (FY) 1973 covered the full range of economic and social needs of the Choctaw people. Designed to complement the progress achieved during FY 1972, the following four developmental…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trudel, Marc; Tucker, Strahan; Morris, John

Historically, salmon stocks from the Columbia River and Snake River formed one of the most valuable fisheries on the west coast of North America. However, salmon and steelhead returns sharply declined during the 1980s and 1990s to reach nearly 1 million fish. Although several factors may be responsible for the decline of Columbia River salmon and steelhead, there is increasing evidence that these drastic declines were primarily attributable to persistently unfavorable ocean conditions. Hence, an understanding of the effects of ocean conditions on salmon production is required to forecast the return of salmon to the Columbia River basin and tomore » assess the efficacy of mitigation measures such as flow regulation on salmon resources in this system. The Canadian Program on High Seas Salmon has been collecting juvenile salmon and oceanographic data off the west coast of British Columbia and Southeast Alaska since 1998 to assess the effects of ocean conditions on the distribution, migration, growth, and survival of Pacific salmon. Here, we present a summary of the work conducted as part of the Canada-USA Salmon Shelf Survival Study during the 2008 fiscal year and compare these results with those obtained from previous years. The working hypothesis of this research is that fast growth enhances the marine survival of salmon, either because fast growing fish quickly reach a size that is sufficient to successfully avoid predators, or because they accumulate enough energy reserves to better survive their first winter at sea, a period generally considered critical in the life cycle of salmon. Sea surface temperature decreased from FY05 to FY08, whereas, the summer biomass of phytoplankton increased steadily off the west coast of Vancouver Island from FY05 to FY08. As in FY07, zooplankton biomass was generally above average off the west coast of Vancouver Island in FY08. Interestingly, phytoplankton and zooplankton biomass were higher in FY08 than was expected from the observed nutrient concentration that year. This suggests nutrients were more effectively by phytoplankton in FY08. In addition, the abundance of lipid-rich northern copepods increased from FY05 to FY08, whereas lipid-poor southern copepods showed the opposite pattern, suggesting that growth conditions were more favorable to juvenile salmon in FY08 than in previous years. However, growth indices for juvenile coho salmon were near the 1998-2008 average, both off the west coast of Vancouver Island and Southeast Alaska, indicating that additional factors beside prey quality affect juvenile salmon growth in the marine environment. Catches of juvenile Chinook, sockeye and chum salmon off the west coast of Vancouver Island in June-July 2008 were the highest on record during summer since 1998, suggesting that early marine survival for the 2008 smolt year was high. Interestingly, the proportion of hatchery fish was high (80-100%) among the juvenile Columbia River Chinook salmon caught off the British Columbia coast during summer, suggest that relatively few wild Chinook salmon are produced in the Columbia River Chinook. In addition, we also recovered two coded-wire tagged juvenile Redfish Lake sockeye salmon in June 2008 off the west coast of British Columbia. As relatively few Redfish Lake sockeye smolts are tagged each year, this also suggests that early marine survival was high for these fish, and may result in a high return in 2009 if they mature at age three, or in 2010 if they mature at age four. To date, our research shows that different populations of Columbia River salmon move to different locations along the coastal zone where they establish their ocean feeding grounds and overwinter. We further show that ocean conditions experienced by juvenile Columbia River salmon vary among regions of the coast, with higher plankton productivity and temperatures off the west coast of Vancouver Island than in Southeast Alaska. Hence, different stocks of juvenile salmon originating from the Columbia River and Snake River are exposed to different ocean conditions and may respond differently to climate changes. In particular, our work shows that the growth and fat content of Chinook and coho salmon vary along different parts of the coast and among years. These growth differences appear to be associated with differences in prey quality rather than by a direct effect of temperature on salmon growth or prey quantity, indicating that changes in ocean conditions and circulation affect salmon production indirectly through changes in prey community composition and quality. Taken together, our analyses indicate that the relative survival of different stocks of salmon in the ocean will depend on where they migrate in the ocean, and that changes at the base of the food chain must be taken into consideration to understand the effects of ocean conditions on salmon growth, and hence, on salmon survival.« less

Biological and Environmental Research Program at Oak Ridge National Laboratory, FY 1992--1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This report is the 1992--1994 Program Director's Overview Report for Oak Ridge National Laboratory's (ORNL's) Biological and Environmental Research (BER) Program, and as such it addresses KP-funded work at ORNL conducted during FY 1991 and in progress during FY 1992; it also serves as a planning document for the remainder of FY 1992 through FY 1994. Non-BER funded work at ORNL relevant to the mission of OHER is also discussed. The second section of the report describes ORNL facilities and resources used by the BER program. The third section addresses research management practices at ORNL. The fourth, fifth, and sixthmore » sections address BER-funded research in progress, program accomplishments and research highlights, and program orientation for the remainder of FY 1992 through FY 1994, respectively. Work for non-BER sponsors is described in the seventh section, followed by a discussion of significant near and long-term issues facing BER work at ORNL in the eighth section. The last section provides a statistical summary of BER research at ORNL. Appendices supplement the above topics with additional detail.« less

Annual Progress Report FY-82. Volume I.

DTIC Science & Technology

1982-01-01

Comparison of Binaural Versus 316 Monaural Amplification. (FY-81PI) 2535 Development of Method for Generating 318 Individualized Aural Rehabilitation...Oncology Group. 428 (FY-74 I ) 4116 The Evaluation of Petal Systolic Time Intervals 429 and Beat interval Variation in Fetal heart Rate as Early

Computer Science Research Funding: How Much Is Too Little?

DTIC Science & Technology

2009-06-01

Bioinformatics Parallel computing Computational biology Principles of programming Computational neuroscience Real-time and embedded systems Scientific...National Security Agency ( NSA ) • Missile Defense Agency (MDA) and others The various research programs have been coordinated through the DDR&E...DOD funding included only DARPA and OSD programs. FY07 and FY08 PBR funding included DARPA, NSA , some of the Services’ basic and applied research

Initial In-flight Results: The Total Solar Irradiance Monitor on the FY-3C Satellite, an Instrument with a Pointing System

NASA Astrophysics Data System (ADS)

Wang, Hongrui; Qi, Jin; Li, Huiduan; Fang, Wei

2017-01-01

The total solar irradiance (TSI) has been recorded daily since October 2013 by the Total Solar Irradiance Monitor (TSIM) onboard the FY-3C satellite, which is mainly designed for Earth observation. The TSIM has a pointing system to perform solar tracking using a sun sensor. The TSI is measured by two electrical substitution radiometers with traceability to the World Radiation Reference. The TSI value measured with the TSIM on 2 October 2013 is 1364.88 W m^{-2} with an uncertainty of 1.08 W m^{-2}. Short-term TSI variations recorded with the TSIM show good agreement with SOHO/VIRGO and SORCE/TIM. The data quality and accuracy of FY-3C/TSIM are much better than its predecessors on the FY-3A and FY-3B satellites, which operated in a scanning mode.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, GE; Diefenderfer, HL

The Estuary/Ocean Subgroup (EOS) is part of the research, monitoring, and evaluation (RME) effort that the Action Agencies (Bonneville Power Administration (BPA), U.S. Army Corps of Engineers, U.S. Bureau of Reclamation) developed in response to obligations arising from the Endangered Species Act as applied to operation of the Federal Columbia River Power System (FCRPS). The goal of the EOS project is to facilitate activities of the estuary/ocean RME subgroup as it coordinates design and implementation of federal RME in the lower Columbia River and estuary. In fiscal year 2008 (FY08), EOS project accomplishments included (1) subgroup meetings; (2) participation inmore » the estuary work group of the Pacific Northwest Aquatic Monitoring Partnership; (3) project management via BPA's project tracking system, Pisces; (4) quarterly project status reports; and (5) a major revision to the Estuary RME document and its subsequent regional release (new version January 2008). Many of the estuary RME recommendations in this document were incorporated into the Biological Opinion on FCRPS operations (May 2008). In summary, the FY08 EOS project resulted in expanded, substantive coordination with other regional RME forums, a new version of the federal Estuary RME program document, and implementation coordination. This annual report is a FY08 deliverable for the project titled Facilitation of the Estuary/Ocean Subgroup.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, Gary E.; Diefenderfer, Heida L.

The Estuary/Ocean Subgroup (EOS) is part of the research, monitoring, and evaluation (RME) effort that the Action Agencies (Bonneville Power Administration, U.S. Army Corps of Engineers, U.S. Bureau of Reclamation) developed in response to obligations arising from the Endangered Species Act as applied to operation of the Federal Columbia River Power System (FCRPS). The goal of the EOS project is to facilitate activities of the estuary/ocean RME subgroup as it coordinates design and implementation of federal RME in the lower Columbia River and estuary. In fiscal year 2008 (FY08), EOS project accomplishments included 1) subgroup meetings; 2) participation in themore » estuary work group of the Pacific Northwest Aquatic Monitoring Partnership; 3) project management via the project tracking system, Pisces; 4) quarterly project status reports; and 5) a major revision to the Estuary RME document and its subsequent regional release (new version January 2008). Many of the estuary RME recommendations in this document were incorporated into the Biological Opinion on hydrosystem operations (May 2008). In summary, the FY08 EOS project resulted in expanded, substantive coordination with other regional RME forums, a new version of the federal Estuary RME program document, and implementation coordination. This annual report is a FY08 deliverable for the project titled Facilitation of the Estuary/Ocean Subgroup.« less

FY2017 Electrification Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

During fiscal year 2017 (FY 2017), the U.S. Department of Energy (DOE) Vehicle Technologies Office (VTO) funded early stage research & development (R&D) projects that address Batteries and Electrification of the U.S. transportation sector. The VTO Electrification Sub-Program is composed of Electric Drive Technologies, and Grid Integration activities. The Electric Drive Technologies group conducts R&D projects that advance Electric Motors and Power Electronics technologies. The Grid and Charging Infrastructure group conducts R&D projects that advance Grid Modernization and Electric Vehicle Charging technologies. This document presents a brief overview of the Electrification Sub-Program and progress reports for its R&D projects. Eachmore » of the progress reports provide a project overview and highlights of the technical results that were accomplished in FY 2017.« less

Cascade Distillation Subsystem Development: Progress Toward a Distillation Comparison Test

NASA Technical Reports Server (NTRS)

Callahan, M. R.; Lubman, A.; Pickering, Karen D.

2009-01-01

Recovery of potable water from wastewater is essential for the success of long-duration manned missions to the Moon and Mars. Honeywell International and a team from NASA Johnson Space Center (JSC) are developing a wastewater processing subsystem that is based on centrifugal vacuum distillation. The wastewater processor, referred to as the Cascade Distillation Subsystem (CDS), utilizes an innovative and efficient multistage thermodynamic process to produce purified water. The rotary centrifugal design of the system also provides gas/liquid phase separation and liquid transport under microgravity conditions. A five-stage subsystem unit has been designed, built, delivered and integrated into the NASA JSC Advanced Water Recovery Systems Development Facility for performance testing. A major test objective of the project is to demonstrate the advancement of the CDS technology from the breadboard level to a subsystem level unit. An initial round of CDS performance testing was completed in fiscal year (FY) 2008. Based on FY08 testing, the system is now in development to support an Exploration Life Support (ELS) Project distillation comparison test expected to begin in early 2009. As part of the project objectives planned for FY09, the system will be reconfigured to support the ELS comparison test. The CDS will then be challenged with a series of human-gene-rated waste streams representative of those anticipated for a lunar outpost. This paper provides a description of the CDS technology, a status of the current project activities, and data on the system s performance to date.

Integrated Defensive Electronic Countermeasures (IDECM)

DTIC Science & Technology

2015-12-01

Selected Acquisition Report ( SAR ) RCS: DD-A&T(Q&A)823-418 Integrated Defensive Electronic Countermeasures (IDECM) As of FY 2017 President’s Budget...Defense Acquisition Management Information Retrieval (DAMIR) March 10, 2016 08:58:42 UNCLASSIFIED IDECM December 2015 SAR March 10, 2016 08:58:42... SAR March 10, 2016 08:58:42 UNCLASSIFIED 3 PB - President’s Budget PE - Program Element PEO - Program Executive Officer PM - Program Manager POE

Identification of a feline leukemia virus variant that can use THTR1, FLVCR1, and FLVCR2 for infection.

PubMed

Shalev, Zvi; Duffy, Simon P; Adema, Karen W; Prasad, Rati; Hussain, Naveen; Willett, Brian J; Tailor, Chetankumar S

2009-07-01

The pathogenic subgroup C feline leukemia virus (FeLV-C) arises in infected cats as a result of mutations in the envelope (Env) of the subgroup A FeLV (FeLV-A). To better understand emergence of FeLV-C and potential FeLV intermediates that may arise, we characterized FeLV Env sequences from the primary FY981 FeLV isolate previously derived from an anemic cat. Here, we report the characterization of the novel FY981 FeLV Env that is highly related to FeLV-A Env but whose variable region A (VRA) receptor recognition sequence partially resembles the VRA sequence from the prototypical FeLV-C/Sarma Env. Pseudotype viruses bearing FY981 Env were capable of infecting feline, human, and guinea pig cells, suggestive of a subgroup C phenotype, but also infected porcine ST-IOWA cells that are normally resistant to FeLV-C and to FeLV-A. Analysis of the host receptor used by FY981 suggests that FY981 can use both the FeLV-C receptor FLVCR1 and the feline FeLV-A receptor THTR1 for infection. However, our results suggest that FY981 infection of ST-IOWA cells is not mediated by the porcine homologue of FLVCR1 and THTR1 but by an alternative receptor, which we have now identified as the FLVCR1-related protein FLVCR2. Together, our results suggest that FY981 FeLV uses FLVCR1, FLVCR2, and THTR1 as receptors. Our findings suggest the possibility that pathogenic FeLV-C arises in FeLV-infected cats through intermediates that are multitropic in their receptor use.

FY 1999 Annual Self-Evaluation Report of the Pacific Northwest National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Randy R. LaBarge

1999-11-05

This is a report of the Pacific Northwest National Laboratory's (Pacific Northwest's) FY1999 Annual Self-Evaluation Report. This report summarizes our progress toward accomplishment of the critical outcomes, objectives, and performance indicators as delineated in the FY1999 Performance Evaluation & Fee Agreement. It also summarizes our analysis of the results of Pacific Northwest's Division and Directorate annual self-assessments, and the implementation of our key operational improvement initiatives. Together, these provide an indication of how well we have used our Integrated Assessment processes to identify and plan improvements for FY2000. As you review the report you will find areas of significantly positivemore » progress; you will also note areas where I believe the Laboratory could make improvements. Overall, however, I believe you will be quite pleased to note that we have maintained, or exceeded, the high standards of performance we have set for the Laboratory.« less

Annual Progress Report (Fiscal Year 1978) of the Clinical Investigation Service

DTIC Science & Technology

1978-01-01

FY-78 0). 2521 Reaction Times of Stutterers and Nonstutterers (FY-78 0). 2522 ^fonaural Versus Binaural Amplification for Hearing Impaired...4113 Cooperative Gynecoloeic-Oncolosv Croup (FY-72 0). 401 4116 The Evaluation of Fetal Systolic Time Intervals and 402 Beat to Beat ...wmmm mmnv r-T" IÜP WORK UNIT NUMBER: 2522 TITLE; Monaural Versus Binaural Amplification for Hearing Impaired Listeners INVESTIGATORS

FY2013 Energy Storage R&D Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2014-02-01

The FY 2013 Progress Report for Energy Storage R&D focuses on advancing the development of batteries to enable a large market penetration of hybrid and electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush.

System Requirements Analysis and Technological Support for the Ballistic Missile Defense System (BMDS) - FY07 Progress Report

DTIC Science & Technology

2007-07-01

Systems , Boeing-led Airborne Laser Team Actively Tracks Airborne Target, Compensates for Atmospheric Turbulence and Fires Sur- rogate High-Energy Laser...7100 System Requirements Analysis and Technological Support for the Ballistic Missile Defense System (BMDS) FY07 Progress Report By...Office of Management and Budget , Paperwork Reduction Project (0704-0188) Washington DC 20503. 1. AGENCY USE ONLY (Leave blank) 2. REPORT DATE July

Impact of the Local Public Hospital Reform on the Efficiency of Medium-Sized Hospitals in Japan: An Improved Slacks-Based Measure Data Envelopment Analysis Approach.

PubMed

Zhang, Xing; Tone, Kaoru; Lu, Yingzhe

2018-04-01

To assess the change in efficiency and total factor productivity (TFP) of the local public hospitals in Japan after the local public hospital reform launched in late 2007, which was aimed at improving the financial capability and operational efficiency of hospitals. Secondary data were collected from the Ministry of Internal Affairs and Communications on 213 eligible medium-sized hospitals, each operating 100-400 beds from FY2006 to FY2011. The improved slacks-based measure nonoriented data envelopment analysis models (Quasi-Max SBM nonoriented DEA models) were used to estimate dynamic efficiency score and Malmquist Index. The dynamic efficiency measure indicated an efficiency gain in the first several years of the reform and then was followed by a decrease. Malmquist Index analysis showed a significant decline in the TFP between 2006 and 2011. The financial improvement of medium-sized hospitals was not associated with enhancement of efficiency. Hospital efficiency was not significantly different among ownership structure and law-application system groups, but it was significantly affected by hospital location. The results indicate a need for region-tailored health care policies and for a more comprehensive reform to overcome the systemic constraints that might contribute to the decline of the TFP. © Health Research and Educational Trust.

Notification: Evaluation of Laboratory Equipment Utilization

EPA Pesticide Factsheets

Project #OPE-FY14-0024, April 08, 2014. The Office of Inspector General plans to begin preliminary research on equipment utilization within the U.S. Environmental Protection Agency Office of Research and Development.

Report of Secretary of Defense, Harold Brown, to the Congress on the FY 1982 Budget, FY 1983 Authorization Request and FY 1982-1986 Defense Programs

DTIC Science & Technology

1981-01-19

a " high -low" mix of high performance ...meet the common threat. 86 Considerable progress is being made. Last year, Japanese ships and aircraft performed very capably in a joint naval exercise... high school graduates, however, does not mean that a high school diploma is necessarily a predictor of on-the-job performance in the military.

2008 Federal Energy Management Program (FEMP) Market Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tremper, C.

2009-07-01

This report assesses the market for Federal Energy Management Program (FEMP) services as it existed in FY 2008. It discusses Federal energy management goal progress in FY 2008, and examines the environment in which agencies implemented energy management projects over the last three years. The report also discusses some recent events that will increase the market for FEMP services, and outlines FEMP's major strategies to address these changes in FY 2009 and beyond.

Fort Collins Science Center - Fiscal Year 2008 Science Accomplishments

USGS Publications Warehouse

Wilson, Juliette T.

2009-01-01

Public land and natural resource managers in the United States are confronted with increasingly complex decisions that have important ramifications for both ecological and human systems. The scientists and technical professionals at the U.S. Geological Survey (USGS) Fort Collins Science Center (FORT) contribute a unique blend of ecological, socioeconomic, and technological expertise to investigating complicated ecological problems that address critical management questions. In Fiscal Year 2008 (FY08), FORT's scientific and technical professionals continued research vital to the science and management needs of U.S. Department of the Interior agencies and other entities. This annual report describes select FY08 accomplishments in research and technical assistance involving biological information management and delivery; aquatic, riparian, and managed-river ecosystems; invasive species; status and trends of biological resources (including human dimensions and social science); terrestrial ecosystems; and fish and wildlife resources.

Transportation Research and Analysis Computing Center (TRACC) Year 6 Quarter 4 Progress Report

DOT National Transportation Integrated Search

2013-03-01

Argonne National Laboratory initiated a FY2006-FY2009 multi-year program with the US Department of Transportation (USDOT) on October 1, 2006, to establish the Transportation Research and Analysis Computing Center (TRACC). As part of the TRACC project...

Compatibility Grab Sampling and Analysis Plan for FY 2000

DOE Office of Scientific and Technical Information (OSTI.GOV)

SASAKI, L.M.

1999-12-29

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for grab samples obtained to address waste compatibility. It is written in accordance with requirements identified in Data Quality Objectives for Tank Farms Waste Compatibility Program (Mulkey et al. 1999) and Tank Farm Waste Transfer Compatibility Program (Fowler 1999). In addition to analyses to support Compatibility, the Waste Feed Delivery program has requested that tank samples obtained for Compatibility also be analyzed to confirm the high-level waste and/or low-activity waste envelope(s) for the tank waste (Baldwin 1999). The analytical requirements tomore » confirm waste envelopes are identified in Data Quality Objectives for TWRS Privatization Phase I: Confirm Tank T is an Appropriate Feed Source for Low-Activity Waste Feed Batch X (Nguyen 1999a) and Data Quality Objectives for RPP Privatization Phase I: Confirm Tank T is an Appropriate Feed Source for High-Level Waste Feed Batch X (Nguyen 1999b).« less

Research administration, state planning & research part II program : FY2012 at-a-glance.

DOT National Transportation Integrated Search

2012-01-01

This publication presents a summary of Research and Library funding statistics and project progress for Fiscal Year (FY) 2012. The tables on pages 2 through 7 list all MDOT-funded research projects by focus area that were active or completed during 2...

Research administration, state planning & research part II program : FY2013 at-a-glance.

DOT National Transportation Integrated Search

2014-01-01

This publication presents a summary of Research and Library funding statistics and project progress for Fiscal Year : (FY) 2013. The tables on pages 2 through 7 list all MDOT-funded research projects by topic area that were active : or completed duri...

FY 2012 Lightweight Materials Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Warren, David C.

2013-04-15

The FY 2012 Annual Progress Report for Lightweight Materials provides a detailed description of the activities and technical accomplishments which focuses on the development and validation of advanced materials and manufacturing technologies to significantly reduce light and heavy duty vehicle weight without compromising other attributes such as safety, performance, recyclability, and cost.

MULTIPLE PROJECTIONS SYSTEM (MPS): USER'S MANUAL VERSION 2.0

EPA Science Inventory

The document is a user's manual for Multiple Projections System (MPS) Version 2.0, based on the 3% reasonable further progress (RFP) tracking system that was developed in FY92/FY93. The 3% RFP tracking system is a Windows application, and enhancements to convert the 3% RFP track...

Unmanned Aircraft Systems (UAS) Integration in the National Airspace System (NAS) Project FY16 Annual Review

NASA Technical Reports Server (NTRS)

Grindle, Laurie; Hackenberg, Davis

2016-01-01

This presentation gives insight into the research activities and efforts being executed in order to integrate unmanned aircraft systems into the national airspace system. This briefing is to inform others of the UAS-NAS FY16 progress and future directions.

Annual Progress Report (FY-80) Department of Clinical Investigation.

DTIC Science & Technology

1980-09-30

Reiter’s Syndrome ) was 17.6% in this population 5/34). Publications: Joseph T. Tesar, -M, Paul Killian MD, David Strong PlhD et al: Acute anterior uveitis...I12 .tate it Pota.sium Balance in the AuilL Acute Leukemic ratient. (FY-78 F) 1127 Characterization and Response to Therapy in- Mild Essential Hyper...Medical Treatment of Amenorrhea-Galactorrhea Syndrome with Vitamin 66 B6 (Pyridoxine). (FY-77 SP I) 1363 Effect of T3 and rT3 on Plasma Cyclic

Demonstration of Thermoplastic Composite I-Beam Design Bridge at Camp Mackall, NC: Final Report on Projects FY08-16 and FY09-31

DTIC Science & Technology

2017-12-01

fastened to the deck surface, with spaces approximately every 6 ft (1.8 m) to allow water to run off... run the length of the bridge, touching edge to edge. The girders are through bolted to the pile caps. Decking is affixed to the girders with deck...fastened to the deck surface, with spaces approximately every 6 ft (1.8 m) to allow water to run off. ERDC/CERL TR-17-45 49 Figure 43. Holes

Genome-wide association study for identifying genome loci that affect fillet yield in rainbow trout (Oncorhynchus mykiss)

USDA-ARS?s Scientific Manuscript database

Fillet yield (FY, %) is an economically important trait in rainbow trout aquaculture that reflects production efficiency. Despite that, FY has not received much attention in breeding programs because it is costly to measure and difficult to select on, limiting the genetic progress in traditional sel...

FY 2009 National Renewable Energy Laboratory (NREL) Annual Report: A Year of Energy Transformation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2010-01-01

This FY2009 Annual Report surveys the National Renewable Energy Laboratory's (NREL) accomplishments in renewable energy and energy efficiency research and development, commercialization and deployment of technologies, and strategic energy analysis. It offers NREL's vision and progress in building a clean, sustainable research campus and reports on community involvement.

Highlands County transit development plan : (FY 2003/04-2007/08)

DOT National Transportation Integrated Search

2002-07-01

To plan for a public transportation system, it is necessary to gain an understanding of the environment within which the system is operating. The following aspects are examined in this report: Demographics; public involvement; existing transportation...

Walter Reed Army Medical Center, Washington, D. C. - Annual Progress Report FY-89. Volume 1

DTIC Science & Technology

1990-01-02

10.9 1 . 10- 5.3 4.8 0o POSITIVE NOT SURE NEGATIVE NOT APPLICABLE I ~FY88 FY89 I This survey of the effectiveness of services offered by the Department...Extracts (3/86) 1 3335 Squire, Edward LTC MC. Do Aeroallergens Exacerbate Atopic 25 Dermatitis (9/87) 3336 Yang, Edward MAJ MC. The Effect of Human...Symptoms Before and After Parathyroid Surgery (4/86) 1381-86 Smallridge, Robert COL MC. Effect of Obesity on 129 Pharmacokinetics of Atropine in Young Men (8

44th Annual Gun and Missile Systems Conference and Exhibition

DTIC Science & Technology

2009-04-09

IR S A R GOT S/ COT S/OT S Client Vie ws We b-Based Vi ews 2D V i s 3D Vi s DS P S T F D S C MT IX WT X ETS Web - Ba...08-Q-1904 on NSWCDD web site – FY10 Announcement (Pending) • EO/ IR /LST integration into a Tier 2 UAS targeting ball • Solicitation FY10, award at...present picture ID. Badges must be worn at all conference functions. Proceedings will be available on the web one to two weeks after

Littoral Combat Ship Mission Modules (LCS MM)

DTIC Science & Technology

2015-12-01

Selected Acquisition Report ( SAR ) RCS: DD-A&T(Q&A)823-443 Littoral Combat Ship Mission Modules (LCS MM) As of FY 2017 President’s Budget Defense...Acquisition Management Information Retrieval (DAMIR) March 9, 2016 08:50:12 UNCLASSIFIED LCS MM December 2015 SAR March 9, 2016 08:50:12 UNCLASSIFIED...Document OSD - Office of the Secretary of Defense O&S - Operating and Support PAUC - Program Acquisition Unit Cost LCS MM December 2015 SAR March 9

F-35 Joint Strike Fighter Aircraft (F-35)

DTIC Science & Technology

2015-12-01

Selected Acquisition Report ( SAR ) RCS: DD-A&T(Q&A)823-198 F-35 Joint Strike Fighter Aircraft (F-35) As of FY 2017 President’s Budget Defense...Acquisition Management Information Retrieval (DAMIR) March 21, 2016 08:47:09 UNCLASSIFIED F-35 December 2015 SAR March 21, 2016 08:47:09 UNCLASSIFIED 2...Document OSD - Office of the Secretary of Defense O&S - Operating and Support PAUC - Program Acquisition Unit Cost F-35 December 2015 SAR March 21

HC/MC-130 Recapitalization Aircraft (HC/MC-130 Recap)

DTIC Science & Technology

2015-12-01

Selected Acquisition Report ( SAR ) RCS: DD-A&T(Q&A)823-257 HC/MC-130 Recapitalization Aircraft (HC/MC-130 Recap) As of FY 2017 President’s Budget...Defense Acquisition Management Information Retrieval (DAMIR) March 18, 2016 08:18:54 UNCLASSIFIED HC/MC-130 Recap December 2015 SAR March 18, 2016...Recap December 2015 SAR March 18, 2016 08:18:54 UNCLASSIFIED 3 PB - President’s Budget PE - Program Element PEO - Program Executive Officer PM - Program

A common pathway for p10 and calyx proteins in progressive stages of polyhedron envelope assembly in AcMNPV-infected Spodoptera frugiperda larvae.

PubMed

Lee, S Y; Poloumienko, A; Belfry, S; Qu, X; Chen, W; MacAfee, N; Morin, B; Lucarotti, C; Krause, M

1996-01-01

The assembly of the polyhedron envelope in baculovirus-infected cells has been the subject of several studies, yet it is still poorly understood. We have used immunogold-labelled antibodies to two baculovirus proteins, p10 and calyx (also referred to as polyhedron envelope protein or PEP), to follow envelope assembly in AcMNPV-infected tissues of Spodoptera frugiperda larvae. We show that, in wild type virus, both proteins colocalize in fibrillar structures and associated electron-dense spacers which progress to encircle the polyhedra, as well as in completed polyhedron envelopes. In cells infected with polyhedrin-negative (PH-) viruses, an unusual proliferation of these spacers was observed suggesting a deregulatory event in the envelope assembly process. Results of Northern and Western blot analysis revealed that synthesis of P10 and calyx mRNA and proteins in PH- AcMNPV is unaffected as compared to wild type virus. Taken together, the observed physical and compositional connection between fibrillar structures, spacers and polyhedron envelopes, as well as the abnormal appearance of the spacers in PH- mutants, provide further evidence in support of a cooperative role of these structures in the assembly of the polyhedron envelope.

FY2011 Annual Progress Report for Propulsion Materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, Patrick B.; Schutte, Carol L.; Gibbs, Jerry L.

Annual Progress Report for Propulsion Materials focusing on enabling and innovative materials technologies that are critical in improving the efficiency of advanced engines by providing enabling materials support for combustion, hybrid, and power electronics development.

Stellar encounters involving neutron stars in globular cluster cores

NASA Technical Reports Server (NTRS)

Davies, M. B.; Benz, W.; Hills, J. G.

1992-01-01

Encounters between a 1.4 solar mass neutron star and a 0.8 solar mass red giant (RG) and between a 1.4 solar mass neutron star (NS) and an 0.8 solar mass main-sequence (MS) star have been successfully simulated. In the case of encounters involving an RG, bound systems are produced when the separation at periastron passage R(MIN) is less than about 2.5 R(RG). At least 70 percent of these bound systems are composed of the RG core and NS forming a binary engulfed in a common envelope of what remains of the former RG envelope. Once the envelope is ejected, a tight white dwarf-NS binary remains. For MS stars, encounters with NSs will produce bound systems when R(MIN) is less than about 3.5 R(MS). Some 50 percent of these systems will be single objects with the NS engulfed in a thick disk of gas almost as massive as the original MS star. The ultimate fate of such systems is unclear.

Southern Rural Development Center Annual Progress Report, FY 1985. SRDC Series No. 80.

ERIC Educational Resources Information Center

Southern Rural Development Center, Mississippi State, MS.

In fiscal year (FY) 1985 the Southern Rural Development Center (SRDC) was engaged in 24 major activities that responded to the rural problems of the region and supported the community development efforts of 29 land-grant universities in 13 southern states, Puerto Rico, and the Virgin Islands. The work of the SRDC Business Management Network…

MODEL DEVELOPMENT FOR FY08 CMAQ RELEASE

EPA Science Inventory

This task provides credible state of the art air quality models and guidance for use in implementation of National Ambient Air Quality Standards for ozone and PM. This research effort is to develop and improve air quality models, such as the Community Multiscale Air Quality (CMA...

Physics division. Progress report, January 1, 1995--December 31, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stewart, M.; Bacon, D.S.; Aine, C.J.

1997-10-01

This issue of the Physics Division Progress Report describes progress and achievements in Physics Division research during the period January 1, 1995-December 31, 1996. The report covers the five main areas of experimental research and development in which Physics Division serves the needs of Los Alamos National Laboratory and the nation in applied and basic sciences: (1) biophysics, (2) hydrodynamic physics, (3) neutron science and technology, (4) plasma physics, and (5) subatomic physics. Included in this report are a message from the Division Director, the Physics Division mission statement, an organizational chart, descriptions of the research areas of the fivemore » groups in the Division, selected research highlights, project descriptions, the Division staffing and funding levels for FY95-FY97, and a list of publications and presentations.« less

Nuclear rocket propulsion. NASA plans and progress, FY 1991

NASA Technical Reports Server (NTRS)

Clark, John S.; Miller, Thomas J.

1991-01-01

NASA has initiated planning for a technology development project for nuclear rocket propulsion systems for space explorer initiative (SEI) human and robotic missions to the moon and Mars. An interagency project is underway that includes the Department of Energy National Laboratories for nuclear technology development. The activities of the project planning team in FY 1990 and 1991 are summarized. The progress to date is discussed, and the project plan is reviewed. Critical technology issues were identified and include: (1) nuclear fuel temperature, life, and reliability; (2) nuclear system ground test; (3) safety; (4) autonomous system operation and health monitoring; and (5) minimum mass and high specific impulse.

Nuclear rocket propulsion: NASA plans and progress - FY 1991

NASA Technical Reports Server (NTRS)

Clark, John S.; Miller, Thomas J.

1991-01-01

NASA has initiated planning for a technology development project for nuclear rocket propulsion systems for space exploration initiative (SEI) human and robotic missions to the Moon and to Mars. An interagency project is underway that includes the Department of Energy National Laboratories for nuclear technology development. The activities of the project planning team in FY 1990 and 1991 are summarized. The progress to date is discussed, and the project plan is reviewed. Critical technology issues were identified and include: (1) nuclear fuel temperature, life, and reliability; (2) nuclear system ground test; (3) safety; (4) autonomous system operation and health monitoring; and (5) minimum mass and high specific impulse.

United States Army Biomedical Research and Development Laboratory Annual Progress Report FY90

DTIC Science & Technology

1991-01-01

pesticide . Parallel and follow-on studies will include hydrolysis products of nerve agents , vesicants, and agents of...Division FO Fog oil FORSCOM U.S. Army Forces Command FY Fiscal year 249 GA The nerve agent tabun GB The nerve agent soman GD The nerve agent sarin GLP... Nerve Agents , Industrial Hygiene Sampling, Microbiology, Combustion Products, Liquid Gun Propellant, Organic Chemistry, Inorganic

2012 Wind Program Peer Review Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zayas, Jose; Higgins, Mark

2012-06-01

This report summarizes the proceedings of the 2012 Wind Program Peer Review, the goals of which were to review and evaluate the strategy and goals of the Wind Program; review and evaluate the progress and accomplishments of the program's projects funded in fiscal year (FY) 2010 and FY 2011; and foster interactions among the national laboratories, industry, and academic institutions conducting research and development on behalf of the program.

Notification: EPA Progress in Reducing Taxpayer Environmental Liabilities

EPA Pesticide Factsheets

Project #OPE-FY15-0052, May 28, 2015. The EPA OIG plans to begin preliminary research on the EPA’s progress in reducing taxpayer liabilities through the use of financial assurance instruments for RCRA facilities and Superfund sites.

Estimation of genetic parameters for productive life, reproduction, and milk-production traits in US dairy goats.

PubMed

Castañeda-Bustos, V J; Montaldo, H H; Torres-Hernández, G; Pérez-Elizalde, S; Valencia-Posadas, M; Hernández-Mendo, O; Shepard, L

2014-01-01

Heritabilities and correlations for milk yield (MY), fat yield (FY), protein yield (PY), combined fat and protein yield (FPY), fat percentage (F%), protein percentage (P%), age at first kidding (AFK), interval between the first and second kidding (KI), and real and functional productive life at 72mo (FPL72) of 33,725 US dairy goats, were estimated using animal models. Productive life was defined as the total days in production until 72mo of age (PL72) for goats having the opportunity to express the trait. Functional productive life was obtained by correcting PL72 for MY, FY, PY, and final type score (FS). Six selection indexes were used, including or excluding PL72, with 6 groups of different economic weights, to estimate the responses to selection considering MY, FY, PY, and PL72 as selection criteria. The main criteria that determined the culling of a goat from the herd were low FS, MY, and FY per lactation. Heritability estimates were 0.22, 0.17, 0.37, 0.37, 0.38, 0.39, 0.54, 0.64, 0.09, and 0.16 for PL72, FPL72, MY, FY, PY, FPY, F%, P%, KI, and AFK, respectively. Most genetic correlations between the evaluated traits and PL72 or FPL72 were positive, except for F% (-0.04 and -0.06, respectively), P% (-0.002 and -0.03, respectively), and AFK (-0.03 and -0.01, respectively). The highest genetic correlations were between FPL72 and MY (0.39) and between PL72 and MY (0.33). Most phenotypic correlations between the traits evaluated and FPL72 and PL72 were positive (>0.23 and >0.26, respectively), except for F% (-0.004 and -0.02, respectively), P% (-0.05 and -0.02), KI (-0.01 and -0.07), and AFK (-0.08 and -0.08). The direct selection for PL72 increased it by 102.28d per generation. The use of MY, FY, PY, KI, or AFK as selection criteria increased PL72 by 39.21, 27.33, 35.90, -8.28, or 2.77d per generation, respectively. The inclusion of PL72 as selection criterion increased the expected response per generation from 0.15 to 17.35% in all selection indices studied. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Magnetic structure of the mixed antiferromagnet NdMn0.8Fe0.2O3

NASA Astrophysics Data System (ADS)

Mihalik, Matúš; Mihalik, Marián; Hoser, Andreas; Pajerowski, Daniel M.; Kriegner, Dominik; Legut, Dominik; Lebecki, Kristof M.; Vavra, Martin; Fitta, Magdalena; Meisel, Mark W.

2017-10-01

The magnetic structure of the mixed antiferromagnet NdMn0.8Fe0.2O3 was resolved. Neutron powder diffraction data definitively resolve the Mn sublattice with a magnetic propagation vector k =(000 ) and with the magnetic structure (Ax,Fy,Gz ) for 1.6 K

Laboratory Directed Research and Development FY2008 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kammeraad, J E; Jackson, K J; Sketchley, J A

The Laboratory Directed Research and Development (LDRD) Program, authorized by Congress in 1991 and administered by the Institutional Science and Technology Office at Lawrence Livermore, is our primary means for pursuing innovative, long-term, high-risk, and potentially high-payoff research that supports the full spectrum of national security interests encompassed by the missions of the Laboratory, the Department of Energy, and National Nuclear Security Administration. The accomplishments described in this annual report demonstrate the strong alignment of the LDRD portfolio with these missions and contribute to the Laboratory's success in meeting its goals. The LDRD budget of $91.5 million for fiscal yearmore » 2008 sponsored 176 projects. These projects were selected through an extensive peer-review process to ensure the highest scientific quality and mission relevance. Each year, the number of deserving proposals far exceeds the funding available, making the selection a tough one indeed. Our ongoing investments in LDRD have reaped long-term rewards for the Laboratory and the nation. Many Laboratory programs trace their roots to research thrusts that began several years ago under LDRD sponsorship. In addition, many LDRD projects contribute to more than one mission area, leveraging the Laboratory's multidisciplinary team approach to science and technology. Safeguarding the nation from terrorist activity and the proliferation of weapons of mass destruction will be an enduring mission of this Laboratory, for which LDRD will continue to play a vital role. The LDRD Program is a success story. Our projects continue to win national recognition for excellence through prestigious awards, papers published in peer-reviewed journals, and patents granted. With its reputation for sponsoring innovative projects, the LDRD Program is also a major vehicle for attracting and retaining the best and the brightest technical staff and for establishing collaborations with universities, industry, and other scientific and research institutions. By keeping the Laboratory at the forefront of science and technology, the LDRD Program enables us to meet our mission challenges, especially those of our ever-evolving national security mission. The Laboratory Directed Research and Development (LDRD) annual report for fiscal year 2008 (FY08) provides a summary of LDRD-funded projects for the fiscal year and consists of two parts: A broad description of the LDRD Program, the LDRD portfolio-management process, program statistics for the year, and highlights of accomplishments for the year. A summary of each project, submitted by the principal investigator. Project summaries include the scope, motivation, goals, relevance to Department of Energy (DOE)/National Nuclear Security Administration (NNSA) and Lawrence Livermore National Laboratory (LLNL) mission areas, the technical progress achieved in FY08, and a list of publications that resulted from the research in FY08. Summaries are organized in sections by research category (in alphabetical order). Within each research category, the projects are listed in order of their LDRD project category: Strategic Initiative (SI), Exploratory Research (ER), Laboratory-Wide Competition (LW), and Feasibility Study (FS). Within each project category, the individual project summaries appear in order of their project tracking code, a unique identifier that consists of three elements. The first is the fiscal year the project began, the second represents the project category, and the third identifies the serial number of the proposal for that fiscal year.« less

Technology Development, Evaluation, and Application (TDEA) FY 1998 Progress Report Environment, Safety, and Health (ESH) Division

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larry G. Hoffman; Kenneth Alvar; Thomas Buhl

1999-06-01

This progress report presents the results of 10 projects funded ($504K) in FY98 by the Technology Development, Evaluation, and Application (TDEA) Committee of the Environment, Safety, and Health Division. Nine projects are new for this year; two projects were completed in their third and final TDEA-funded year. As a result of their TDEA-funded projects, investigators have published 19 papers in professional journals, proceedings, or Los Alamos reports and presented their work at professional meetings. Supplemental funds and in-kind contributions, such as staff time, instrument use, and work space were also provided to the TDEA-funded projects by organizations external to ESHmore » Division. Products generated from the projects funded in FY98 included a new extremity dosimeter that replaced the previously used finger-ring dosimeters, a light and easy-to-use detector to measure energy deposited by neutron interactions, and a device that will allow workers to determine the severity of a hazard.« less

The origin and evolution of dust in interstellar and circumstellar environments

NASA Technical Reports Server (NTRS)

Whittet, Douglas C. B.; Leung, Chun M.

1993-01-01

This status report covers the period from the commencement of the research program on 1 Jul. 1992 through 30 Apr. 1993. Progress is reported for research in the following areas: (1) grain formation in circumstellar envelopes; (2) photochemistry in circumstellar envelopes; (3) modeling ice features in circumstellar envelopes; (4) episodic dust formation in circumstellar envelopes; (5) grain evolution in the diffuse interstellar medium; and (6) grain evolution in dense molecular clouds.

Microgravity science and applications. Program tasks and bibliography for FY 1994

NASA Technical Reports Server (NTRS)

1995-01-01

This annual report includes research projects funded by the Office of Life and Microgravity Sciences and Applications, Microgravity Science and Applications Division, during FY 1994. It is a compilation of program tasks (objective, description, significance, progress, students funded under research, and bibliographic citations) for flight research and ground-based research in five major scientific disciplines: benchmark science, biotechnology, combustion science, fluid physics, and materials science. ATD (Advanced Technology Development) program task descriptions are also included. The bibliography cites the related PI (Principal Investigator) publications and presentations for these program tasks in FY 1994. Three appendices include Table of Acronyms, Guest Investigator Index, and Principal Investigator Index.

Microgravity science & applications. Program tasks and bibliography for FY 1995

NASA Technical Reports Server (NTRS)

1996-01-01

This annual report includes research projects funded by the Office of Life and Microgravity Sciences and Applications, Microgravity Science and Applications Division, during FY 1994. It is a compilation of program tasks (objective, description, significance, progress, students funded under research, and bibliographic citations) for flight research and ground based research in five major scientific disciplines: benchmark science, biotechnology, combustion science, fluid physics, and materials science. Advanced technology development (ATD) program task descriptions are also included. The bibliography cites the related principle investigator (PI) publications and presentations for these program tasks in FY 1994. Three appendices include a Table of Acronyms, a Guest Investigator index and a Principle Investigator index.

Annual Progress Report Fiscal Year 1982.

DTIC Science & Technology

1982-09-30

255 Work Jnit No. 82/43 (FY82,O) A\\dolescent Immunity to Varicella and Cytomegalovirus .............. 256 Work Unit No. 82/45 (FY82,O) V!1-26 In...with technetium-99m bone agent(Infarct avid) radiopharmaceuticals. Presented at the New Mexico Society of Internal Medicine, Albuquerque NM, 11-12 Dec...No: 82/43 Status: Ongoing Title: Adolescent Immunity to Varicella and Cytomegalovirus Start Date: Est Comp Date: Principal Investigator: Facility: LTC

Annual Progress Report (FY-79) Clinical Investigation Service. Walter Reed Army Medical Center

DTIC Science & Technology

1979-09-30

Determination of Gram 311 Negative Meningtis Septic Arthritis and Contamination of Intra- venous Fluids. (FY18 0) 1908 Evaluation of Sodium Stibogluconate... Venous L-Phenylalannie Mustard. Accepted for publication in Cancer Treatment Reports. Cuttner, J., et al. A Controlled Trial of Chemoimmunotherapy in...Boston, Mass, 11-12 Oct 1979. (Abstract) DEPATIT-NENT OF SURGERY Cornwell CG. Hypersensitivity Reaetlons to Intra- Venous L-Phenylalanine M.Vustard

Atypical Chemokine Receptor 1 polymorphism cannot be used as an indicator of liver fibrosis progression in Hepatitis C virus positive patients

PubMed Central

Shao, Lin-Nan; Zhang, Shu-Ting; Zhou, Shi-Hang; Yu, Wei-Jian; Liu, Ming

2017-01-01

Background & Objective: Atypical chemokine receptor 1(ACKR1) represents an atypical chemokine receptor that can bind promiscuously to various chemokines. Chemokines play a crucial role to recruit leukocyte subsets migration through the endothelium and into liver against the virus during the progression of hepatitis C virus (HCV) infection. Most HCV positive patients can lead to liver fibrosis. Hyaluronic acid (HA), laminin (LN), collagen IV(C-IV) and amino-terminal pro-peptide of Type-III pro-collagen (PIII NP) are indices of the extent of liver fibrosis. The aim of this study was to investigate the association between ACKR1 polymorphism and liver fibrosis with these four serum liver markers in HCV positive patients. Methods: From April 2015 to December 2015, a total of 210 patients (109 males and 101 females) with chronic HCV infection at Dalian Infectious Hospital were recruited to participate in this study. ACKR1 genotyping was using TaqMan probes method. HA, LN, C-IV and PIII NP were detected by using diagnostic kits. Results: We compared serum levels of HA, LN, C-IV and PIII NP between FY*A/FY*A and FY*A/FY*B patients and the differences were not significant (P=0.905, P=0.298, P=0.880 and P=0.470, respectively). Conclusions: This study has attempted to elucidate the role of ACKR1 polymorphism in liver fibrosis progression of HCV infection, our results demonstrated that ACKR1 polymorphism is not directly associated with the fibrogenesis in HCV positive patients. PMID:29142552

Longitudinal analyses of correlated response efficiencies of fillet traits in Nile tilapia.

PubMed

Turra, E M; Fernandes, A F A; de Alvarenga, E R; Teixeira, E A; Alves, G F O; Manduca, L G; Murphy, T W; Silva, M A

2018-03-01

Recent studies with Nile tilapia have shown divergent results regarding the possibility of selecting on morphometric measurements to promote indirect genetic gains in fillet yield (FY). The use of indirect selection for fillet traits is important as these traits are only measurable after harvesting. Random regression models are a powerful tool in association studies to identify the best time point to measure and select animals. Random regression models can also be applied in a multiple trait approach to analyze indirect response to selection, which would avoid the need to sacrifice candidate fish. Therefore, the aim of this study was to investigate the genetic relationships between several body measurements, weight and fillet traits throughout the growth period and to evaluate the possibility of indirect selection for fillet traits in Nile tilapia. Data were collected from 2042 fish and was divided into two subsets. The first subset was used to estimate genetic parameters, including the permanent environmental effect for BW and body measurements (8758 records for each body measurement, as each fish was individually weighed and measured a maximum of six times). The second subset (2042 records for each trait) was used to estimate genetic correlations and heritabilities, which enabled the calculation of correlated response efficiencies between body measurements and the fillet traits. Heritability estimates across ages ranged from 0.05 to 0.5 for height, 0.02 to 0.48 for corrected length (CL), 0.05 to 0.68 for width, 0.08 to 0.57 for fillet weight (FW) and 0.12 to 0.42 for FY. All genetic correlation estimates between body measurements and FW were positive and strong (0.64 to 0.98). The estimates of genetic correlation between body measurements and FY were positive (except for CL at some ages), but weak to moderate (-0.08 to 0.68). These estimates resulted in strong and favorable correlated response efficiencies for FW and positive, but moderate for FY. These results indicate the possibility of achieving indirect genetic gains for FW and by selecting for morphometric traits, but low efficiency for FY when compared with direct selection.

Technology Development, Evaluation, and Application (TDEA) FY 2001 Progress Report Environment, Safety, and Health (ESH) Division

DOE Office of Scientific and Technical Information (OSTI.GOV)

L.G. Hoffman; K. Alvar; T. Buhl

2002-05-01

This progress report presents the results of 11 projects funded ($500K) in FY01 by the Technology Development, Evaluation, and Application (TDEA) Committee of the Environment, Safety, and Health Division (ESH). Five projects fit into the Health Physics discipline, 5 projects are environmental science and one is industrial hygiene/safety. As a result of their TDEA-funded projects, investigators have published sixteen papers in professional journals, proceedings, or Los Alamos reports and presented their work at professional meetings. Supplement funds and in-kind contributions, such as staff time, instrument use, and workspace, were also provided to TDEA-funded projects by organizations external to ESH Divisions.

Progress Towards providing Heat-Shield for Extreme Entry Environment Technology (HEEET) for Venus and other New Froniters Missions

NASA Technical Reports Server (NTRS)

Venkatapathy, Ethiraj; Ellerby, Don; Gage, Peter

2017-01-01

Heat-shield for Extreme Entry Environment Technology (HEEET) has been in development since 2014 with the goal of enabling missions to Venus, Saturn and other high-speed sample return missions. It is offered as a new technology and incentivized for mission use in the New Frontiers 4 AO by NASA. The current plans are to mature the technology to TRL 6 by FY18. The HEEET Team has been working closely with multiple NF-4 proposals to Venus, Saturn and has been supporting recent Ice-Giants mission studies. This presentation will provide progress made to date and the plans for development in FY18.

FY2013 Progress Report for Fuel & Lubricant Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2014-02-01

Annual progress report for Fuel & Lubricant Technologies. The Fuel & Lubricant Technologies Program supports fuels and lubricants research and development (R&D) to provide vehicle manufacturers and users with cost-competitive options that enable high fuel economy with low emissions, and contribute to petroleum displacement.

FY2014 Fuel & Lubricant Technologies Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stork, Kevin

2016-02-01

Annual progress report for Fuel & Lubricant Technologies. The Fuel & Lubricant Technologies Program supports fuels and lubricants research and development (R&D) to provide vehicle manufacturers and users with cost-competitive options that enable high fuel economy with low emissions, and contribute to petroleum displacement.

Progressive Tinnitus Management Level 3 Skills Education: A 5-Year Clinical Retrospective.

PubMed

Edmonds, Catherine M; Ribbe, Cheri; Thielman, Emily J; Henry, James A

2017-09-18

The primary purpose of this study was to determine whether progressive tinnitus management Level 3 skills education workshops conducted at the Bay Pines and Boston Veterans Affairs hospitals result in consistent use of the presented tinnitus management strategies by patients 1-5 years after completing the workshops. In fiscal year (FY) 2015, the tinnitus workshop follow-up form was mailed to all veterans who completed the Level 3 workshops between FY 2010 and FY 2014. Data were compiled to determine which, if any, of the skills taught in the workshops were being used 1-5 years after completion of the workshops and the impact on quality-of-life indicators. All self-management skills were being utilized up to 5 years postcompletion; therapeutic sound was utilized the most. The majority of patients reported an improved ability to manage reactions to tinnitus and improved quality-of-life indicators. Over 90% of patients from both sites recommended the program to others with tinnitus. The self-management skills taught in the progressive tinnitus management Level 3 workshops are sustained over time even when limited resources prevent the full complement of workshops or the involvement of mental health services. The workshops can also be successfully implemented through remote delivery via videoconferencing (telehealth). https://doi.org/10.23641/asha.5370883.

Department of Clinical Investigation Annual Research Progress Report, FY 1992

DTIC Science & Technology

1992-09-30

and DES. Patients with a history of deep vein thrombosis, cerebral embolus, stroke , congestive heart failure, or ischemic heart disease will not be...Tracheal Epithelial Injury and Regeneration Following Endotracheal Suctioning. PRINICIPAL INVESTIGATOR: COL Barbara S. Turner, AN 4 4 U U EXTRAMURAL...Suctioning in Adults with Head Injury . Heart Baun M, Stone KS, and Lung 20(6): 667-74, 1991. Brucia JI 11I! PUBLICATIONS - MAMC - FY 92 1 Stowe HO Into

Insensitive Munitions Advanced Development FY 89 Program Plan

DTIC Science & Technology

1989-01-01

reduced vulnerability. The development of castable, moderately energetic explosives such as PBXN - 106 , PBXN -107, and PBX(AF)-108 I for fragment...PROGRESS: Following the successful processing of PBXN - 106 and PBXN -109 in a 37mm Werner Pfleiderer continuous mixer/extruder under contract (ICT/FRG) within...the FY86/87 timeframe, the installation of a similar setup was completed at NSWC and the first live mix ( PBXN - 106 ) was processed during the second

Ethanol annual report FY 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Texeira, R.H.; Goodman, B.J.

This report summarizes the research progress and accomplishments of the US Department of Energy (DOE) Ethanol from Biomass Program, field managed by the Solar Energy Research Institute, during FY 1990. The report includes an overview of the entire program and summaries of individual research projects. These projects are grouped into the following subject areas: technoeconomic analysis; pretreatment; cellulose conversion; xylose fermentation; and lignin conversion. Individual papers have been indexed separately for inclusion on the data base.

Columbia River Basin Fish and Wildlife Program Work Plan for Fiscal Year 1989.

DOE Office of Scientific and Technical Information (OSTI.GOV)

United States. Bonneville Power Administration. Division of Fish and Wildlife.

1988-11-01

The FY 1989 Columbia River Basin Fish and Wildlife Program Work Plan (Work Plan) presents Bonneville Power Administration's plans for implementing the Columbia River Basin Fish and Wildlife Program (Program) in FY 1989. The Work Plan focuses on individual Action Items found in the 1987 Program for which Bonneville Power Administration (BPA) has determined that it has authority and responsibility to implement. Each of the entries in the Work Plan includes objectives, background, and progress to date in achieving those objectives, and a summary of plans for implementation in FY 1989. Most Action Items are implemented through one or moremore » BPA-funded projects. Each Action Item entry is followed by a list of completed, ongoing, and planned projects, along with objectives, results, schedules, and milestones for each project. The FY 1989 Work Plan emphasizes continuation of 113 projects, most of which involve protection, mitigation, or enhancement of anadromous fishery resources. BPA also plans to start 20 new projects in FY 1989. The number of ongoing FY 1988 projects to be continued in FY 1989 and the number of new projects planned to start in FY 1989 are based on current (September 7, 1988) procurement expectations. Several projects presently in BPA's procurement process are expected to be contracted by September 30, 1988, the last day of FY 1988. Although these projects have not yet started, they have been listed in the Work Plan as ongoing FY 1988 projects, based on projected start dates in late September 1988. Throughout the Work Plan, those projects with projected start dates in September 1988 have been noted.« less

Engaging US Business in Support of National Security Objectives Task Group Report

DTIC Science & Technology

2008-01-16

meetings of the Business Round Table, the U.S. Chamber of Commerce , and the National Association of REPORT FY08-1 2 Defense Business Board...Round Table, the U.S. Chamber of Commerce , and the National Association of Manufacturers are representative high-level fora where such dialogue would

Novel Peptide with Specific Calcium-Binding Capacity from Schizochytrium sp. Protein Hydrolysates and Calcium Bioavailability in Caco-2 Cells

PubMed Central

Cai, Xixi; Lin, Jiaping; Wang, Shaoyun

2016-01-01

Peptide-calcium can probably be a suitable supplement to improve calcium absorption in the human body. In this study, a specific peptide Phe-Tyr (FY) with calcium-binding capacity was purified from Schizochytrium sp. protein hydrolysates through gel filtration chromatography and reversed phase HPLC. The calcium-binding capacity of FY reached 128.77 ± 2.57 μg/mg. Results of ultraviolet spectroscopy, fluorescence spectroscopy, and infrared spectroscopy showed that carboxyl groups, amino groups, and amido groups were the major chelating sites. FY-Ca exhibited excellent thermal stability and solubility, which were beneficial to be absorbed and transported in the basic intestinal tract of the human body. Moreover, the calcium bioavailability in Caco-2 cells showed that FY-Ca could enhance calcium uptake efficiency by more than three times when compared with CaCl2, and protect calcium ions against dietary inhibitors, such as tannic acid, oxalate, phytate, and Zn2+. Our findings further the progress of algae-based peptide-calcium, suggesting that FY-Ca has the potential to be developed as functionally nutraceutical additives. PMID:28036002

Pacific Northwest Laboratory annual report for 1990 to the DOE Office of Energy Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Owczarski, E.L.

At the start of FY 1990, the atmospheric sciences and carbon dioxide research programs within the Office of Health and Environmental Research (OHER) were gathered into the new Atmospheric and Climate Research Division (ACRD). One of the central missions of this new division is to provide the Department of Energy with scientifically defensible information on the local, regional, and global distributions of energy-related pollutants and their effects on climate. This information is vital to the definition and implementation of a sound national energy strategy. Because much of the work done at PNL during FY 1990 falls under the umbrella ofmore » the new ACRD, we are including in this volume the progress and status reports for all OHER atmospheric and climate research projects at PNL. The description of ongoing atmospheric and climate research at PNL is organized along two broad research areas; atmospheric research and climate research. This report describes the progress in FY 1990 in each of these areas. A divider page summarizes the goals of each area and lists projects that support research activities.« less

US Army Medical Bioengineering Research and Development Laboratory Annual Progress Report for FY 83.

DTIC Science & Technology

1983-10-01

Army consumes is chlorinated. Also, the water from Army wastewater treatment plants is chlorinated before it is returned to the environment.I Because...12K; CY - K; BY - OK PROBLEM DEFINITION: Chlorination of drinking water and of effluents from wastewater treatment plants is standard practice employed...FY81 indicated no research - activity on this type of photocell. Materials and chemicals have been ordered and assembled. A preliminary cell has been

Environmental Sciences Division annual progress report for period ending September 30, 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1994-12-31

This progress report summarizes the research and development activities conducted in the Environmental Sciences Division (ESD) of Oak Ridge National Laboratory during fiscal year (FY) 1994, which extended from October 1, 1993, through September 30, 1994. The report is structured to provide descriptions of current activities and accomplishments in each of the division`s major organizational units. Following the sections describing the organizational units are sections highlighting ESD Scientific, Technical, and Administrative Achievement awards and listing information necessary to covey the scope of the work in the division. An organizational chart of staff and long-term guests who wee in ESD atmore » the end of FY 1994 is located in the final section of the report.« less

Laboratory Directed Research and Development FY 1998 Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

John Vigil; Kyle Wheeler

This is the FY 1998 Progress Report for the Laboratory Directed Research and Development (LDRD) Program at Los Alamos National Laboratory. It gives an overview of the LDRD Program, summarizes work done on individual research projects, relates the projects to major Laboratory program sponsors, and provides an index to the principle investigators. Project summaries are grouped by their LDRD component: Competency Development, Program Development, and Individual Projects. Within each component, they are further grouped into nine technical categories: (1) materials science, (2) chemistry, (3) mathematics and computational science, (4) atomic, molecular, optical, and plasma physics, fluids, and particle beams, (5)more » engineering science, (6) instrumentation and diagnostics, (7) geoscience, space science, and astrophysics, (8) nuclear and particle physics, and (9) bioscience.« less

Laboratory directed research and development: FY 1997 progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vigil, J.; Prono, J.

1998-05-01

This is the FY 1997 Progress Report for the Laboratory Directed Research and Development (LDRD) program at Los Alamos National Laboratory. It gives an overview of the LDRD program, summarizes work done on individual research projects, relates the projects to major Laboratory program sponsors, and provides an index to the principal investigators. Project summaries are grouped by their LDRD component: Competency Development, Program Development, and Individual Projects. Within each component, they are further grouped into nine technical categories: (1) materials science, (2) chemistry, (3) mathematics and computational science, (4) atomic and molecular physics and plasmas, fluids, and particle beams, (5)more » engineering science, (6) instrumentation and diagnostics, (7) geoscience, space science, and astrophysics, (8) nuclear and particle physics, and (9) bioscience.« less

Report on research and technology-FY 1981

NASA Technical Reports Server (NTRS)

1981-01-01

More than 65 technical reports, papers, and articles published by personnel and contractors at the Dryden Flight Research Center are listed. Activities performed for the Offices of Aeronautics and Space Technology, Space and Terrestrial Applications, Space Transportation Systems, and Space Tracking and Data Systems are summarized. Preliminary stability and control derivatives were determined for the shuttle orbiter at hypersonic speeds from the data obtained at reentry. The shuttle tile tests, spin research vehicle nose shapes flight investigations, envelope expansion flights for the Ames tilt rotor research aircraft, and the AD-1 oblique wing programs were completed as well as the KC-135 winglet program.

Notification: EPA Progress on Meeting Resource Conservation and Recovery Act Statutory Mandate for Minimum Frequency of Inspections at Hazardous Waste Disposal Facilities

EPA Pesticide Factsheets

Project #OPE-FY15-0018, January 20, 2015. The EPA OIG plans to begin preliminary research on EPA’s progress in meeting minimum inspection requirements under the RCRA at treatment, storage and disposal facilities (TSDFs).

(DCT-FY08) Target Detection Using Multiple Modality Airborne and Ground Based Sensors

DTIC Science & Technology

2013-03-01

Plenoptic modeling: an image-based rendering system,” in SIGGRAPH ’95: Proceedings of the 22nd annual conference on Computer graphics and interactive...techniques. New York, NY, USA: ACM, 1995, pp. 39–46. [21] D. G. Aliaga and I. Carlbom, “ Plenoptic stitching: a scalable method for reconstructing 3D

Building America Systems Integration Research Annual Report. FY 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gestwick, Michael

2013-05-01

This Building America FY2012 Annual Report includes an overview of the Building America Program activities and the work completed by the National Renewable Energy Laboratory and the Building America industry consortia (the Building America teams). The annual report summarizes major technical accomplishments and progress towards U.S. Department of Energy Building Technologies Program's multi-year goal of developing the systems innovations that enable risk-free, cost effective, reliable and durable efficiency solutions that reduce energy use by 30%-50% in both new and existing homes.

Used Fuel Disposition in Crystalline Rocks: FY16 Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Y.; Hadgu, Teklu; Kalinina, Elena Arkadievna

The objective of the Crystalline Disposal R&D Work Package is to advance our understanding of long-term disposal of used fuel in crystalline rocks and to develop necessary experimental and computational capabilities to evaluate various disposal concepts in such media. FY16 continued to be a successful year in both experimental and modeling arenas in evaluation of used fuel disposal in crystalline rocks. The work covers a wide range of research topics identified in the R&D plan.

Studies and Reports Relating to Training and Education, FY 1968.

ERIC Educational Resources Information Center

Civil Service Commission, Washington, DC.

The 1968 directory of Federal training and education programs has been compiled to encourage wider use of findings by other agencies, to avoid duplication of research efforts, and to stimulate experimentation needed to keep pace with technological progress. Federal agencies report both completed and in-progress studies and include such agencies as…

Straight A's: Public Education Policy and Progress. Volume 11, Number 5

ERIC Educational Resources Information Center

Amos, Jason, Ed.

2011-01-01

"Straight A's: Public Education Policy and Progress" is a biweekly newsletter that focuses on education news and events both in Washington, DC and around the country. The following articles are included in this issue: (1) Waiting Game Continues for FY 2011 Appropriations: Short-Term Spending Measure Averts Government Shutdown, Postpones…

Straight A's: Public Education Policy and Progress. Volume 10, Number 3

ERIC Educational Resources Information Center

Alliance for Excellent Education, 2010

2010-01-01

"Straight A's: Public Education Policy and Progress" is a biweekly newsletter that focuses on education news and events both in Washington, DC and around the country. The following articles are included in this issue: (1) Obama Releases FY 2011 Budget: Obama's 7.5 Percent Increase for Education Programs Signals Commitment to Reauthorize…

Straight A's: Public Education Policy and Progress. Volume 11, Number 7

ERIC Educational Resources Information Center

Amos, Jason, Ed.

2011-01-01

"Straight A's: Public Education Policy and Progress" is a biweekly newsletter that focuses on education news and events both in Washington, DC and around the country. The following articles are included in this issue: (1) FY 2011 Spending Discussions Continue: Pressure Mounts as April 8 Deadline Approaches and Possibility of Government Shutdown…

Commercial Sensory Survey Radiation Testing Progress Report

NASA Technical Reports Server (NTRS)

Becker, Heidi N.; Dolphic, Michael D.; Thorbourn, Dennis O.; Alexander, James W.; Salomon, Phil M.

2008-01-01

The NASA Electronic Parts and Packaging (NEPP) Program Sensor Technology Commercial Sensor Survey task is geared toward benefiting future NASA space missions with low-cost, short-duty-cycle, visible imaging needs. Such applications could include imaging for educational outreach purposes or short surveys of spacecraft, planetary, or lunar surfaces. Under the task, inexpensive commercial grade CMOS sensors were surveyed in fiscal year 2007 (FY07) and three sensors were selected for total ionizing dose (TID) and displacement damage dose (DDD) tolerance testing. The selected sensors had to meet selection criteria chosen to support small, low-mass cameras that produce good resolution color images. These criteria are discussed in detail in [1]. This document discusses the progress of radiation testing on the Micron and OmniVision sensors selected in FY07 for radiation tolerance testing.

Implementation of a new algorithm for Density Equalizing Map Projections (DEMP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Close, E.R.; Merrill, D.W.; Holmes, H.H.

The purpose of the PAREP (Populations at Risk to Environmental Pollution) Project at Lawrence Berkeley National Laboratory (LBNL), an ongoing Department of Energy (DOE) project since 1978, is to develop resources (data, computing techniques, and biostatistical methodology) applicable to DOE`s needs. Specifically, the PAREP project has developed techniques for statistically analyzing disease distributions in the vicinity of supposed environmental hazards. Such techniques can be applied to assess the health risks in populations residing near DOE installations, provided adequate small-area health data are available. The FY 1994 task descriptions for the PAREP project were determined in discussions at LBNL on 11/2/93.more » The FY94 PAREP Work Authorization specified three major tasks: a prototype small area study, a feasibility study for obtaining small-area data, and preservation of the PAREP data archive. The complete FY94 work plan, and the subtasks accomplished to date, were included in the Cumulative FY94 progress report.« less

FY08 Chemical Synthesis for the Self-Decontaminating Coatings Project

DTIC Science & Technology

2013-08-01

These synthesized materials consist of Boltorn hyperbranched polymers that are functionalized with hydantoin, alkyl, and perfluorinated groups. 15...envisioned that completely prevents sorption of chemical agents, enables autonomous decontamination, reduces the volume of cleaning solution...modified with perfluorinated octanoic acid (PFOA), lauric acid, and a hydantoin moiety. HO OH CH3 HO O 3 Figure 2. Synthetic targets 1–3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crossno, Patricia Joyce; Dunlavy, Daniel M.; Stanton, Eric T.

This report is a summary of the accomplishments of the 'Scalable Solutions for Processing and Searching Very Large Document Collections' LDRD, which ran from FY08 through FY10. Our goal was to investigate scalable text analysis; specifically, methods for information retrieval and visualization that could scale to extremely large document collections. Towards that end, we designed, implemented, and demonstrated a scalable framework for text analysis - ParaText - as a major project deliverable. Further, we demonstrated the benefits of using visual analysis in text analysis algorithm development, improved performance of heterogeneous ensemble models in data classification problems, and the advantages ofmore » information theoretic methods in user analysis and interpretation in cross language information retrieval. The project involved 5 members of the technical staff and 3 summer interns (including one who worked two summers). It resulted in a total of 14 publications, 3 new software libraries (2 open source and 1 internal to Sandia), several new end-user software applications, and over 20 presentations. Several follow-on projects have already begun or will start in FY11, with additional projects currently in proposal.« less

Microgravity science and applications: Program tasks and bibliography for FY 1992

NASA Technical Reports Server (NTRS)

1993-01-01

This report is a compilation of the FY 1992 Principal Investigator program task descriptions funded by the Microgravity Science and Applications Division (MSAD), NASA Headquarters, Washington, DC. The document also provides a bibliography of FY 1992 publications and presentations cited by MSAD Principal Investigators, and an index of the Principal Investigators and their affiliations. The purpose of the document is to provide an overview and progress report for the funded tasks for scientists and researchers in industry, university, and government communities. The tasks are grouped into three categories appropriate to the type of research being done-space flight, ground based, and advanced technology development-and by science discipline. The science disciplines are: biotechnology, combustion science,, electronic materials, fluid physics, fundamental physics, glass and ceramics, metals and alloys, and protein crystal growth.

NASA's Microgravity Research Program

NASA Technical Reports Server (NTRS)

Woodard, Dan

1998-01-01

This fiscal year (FY) 1997 annual report describes key elements of the NASA Microgravity Research Program (MRP) as conducted by the Microgravity Research Division (MRD) within NASA's Office of Life and Microgravity, Sciences and Applications. The program's goals, approach taken to achieve those goals, and program resources are summarized. All snapshots of the program's status at the end of FY 1997 and a review of highlights and progress in grounds and flights based research are provided. Also described are major space missions that flew during FY 1997, plans for utilization of the research potential of the International Space Station, the Advanced Technology Development (ATD) Program, and various educational/outreach activities. The MRP supports investigators from academia, industry, and government research communities needing a space environment to study phenomena directly or indirectly affected by gravity.

MFTF-. cap alpha. + T progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, W.D.

1985-04-01

Early in FY 1983, several upgrades of the Mirror Fusion Test Facility (MFTF-B) at Lawrence Livermore National Laboratory (LLNL) were proposed to the fusion community. The one most favorably received was designated MFTF-..cap alpha..+T. The engineering design of this device, guided by LLNL, has been a principal activity of the Fusion Engineering Design Center during FY 1983. This interim progress report represents a snapshot of the device design, which was begun in FY 1983 and will continue for several years. The report is organized as a complete design description. Because it is an interim report, some parts are incomplete; theymore » will be supplied as the design study proceeds. As described in this report, MFTF-..cap alpha..+T uses existing facilities, many MFTF-B components, and a number of innovations to improve on the physics parameters of MFTF-B. It burns deuterium-tritium and has a central-cell Q of 2, a wall loading GAMMA/sub n/ of 2 MW/m/sup 2/ (with a central-cell insert module), and an availability of 10%. The machine is fully shielded, allows hands-on maintenance of components outside the vacuum vessel 24 h after shutdown, and has provisions for repair of all operating components.« less

Materials science and engineering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lesuer, D.R.

1997-02-01

During FY-96, work within the Materials Science and Engineering Thrust Area was focused on material modeling. Our motivation for this work is to develop the capability to study the structural response of materials as well as material processing. These capabilities have been applied to a broad range of problems, in support of many programs at Lawrence Livermore National Laboratory. These studies are described in (1) Strength and Fracture Toughness of Material Interfaces; (2) Damage Evolution in Fiber Composite Materials; (3) Flashlamp Envelope Optical Properties and Failure Analysis; (4) Synthesis and Processing of Nanocrystalline Hydroxyapatite; and (5) Room Temperature Creep Compliancemore » of Bulk Kel-E.« less

Endolithic algae and micrite envelope formation in Bahamian oolites as revealed by scanning electron microscopy.

NASA Technical Reports Server (NTRS)

Margolis, S.; Rex, R. W.

1971-01-01

Examination of Holocene Bahamian ooelites by scanning electron and light microscopy has revealed the morphology and orientation of aragonite crystals in the lamellar ooelitic envelope, and their modification by the boring activities of endolithic algae. The voids produced by these algae are found in progressive stages of being lined and filled with precipitated microcrystalline aragonite, which is similar to the process of micrite envelope formation in molluscan and other skeletal carbonate grains.

Straight A's: Public Education Policy and Progress. Volume 11, Number 8

ERIC Educational Resources Information Center

Amos, Jason, Ed.

2011-01-01

"Straight A's: Public Education Policy and Progress" is a biweekly newsletter that focuses on education news and events both in Washington, DC and around the country. The following articles are included in this issue: (1) Last Cut Is the Deepest: Final FY 2011 Spending Agreement Cuts Spending by Nearly $40 Billion, Includes More Cuts for Education…

Straight A's: Public Education Policy and Progress. Volume 11, Number 4

ERIC Educational Resources Information Center

Amos, Jason, Ed.

2011-01-01

"Straight A's: Public Education Policy and Progress" is a biweekly newsletter that focuses on education news and events both in Washington, DC and around the country. The following articles are included in this issue: (1) House Passes FY 2011 Spending Bill: Bill Cuts U.S. Department of Education Funding by $5 Billion; Title I, School…

Solar Thermal Power Systems parabolic dish project

NASA Technical Reports Server (NTRS)

Truscello, V. C.

1981-01-01

The status of the Solar Thermal Power Systems Project for FY 1980 is summarized. Included is: a discussion of the project's goals, program structure, and progress in parabolic dish technology. Analyses and test results of concentrators, receivers, and power converters are discussed. Progress toward the objectives of technology feasibility, technology readiness, system feasibility, and system readiness are covered.

Chemistry and materials science progress report, FY 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-07-01

Research is reported in the areas of surface science, fundamentals of the physics and processing of metals, energetic materials, transactinide materials and properties and other indirectly related areas of weapons research.

Targeted Technology Transfer to US Independents

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schatzinger, Viola; Chapman, Kathy; Lovendahl, Kristi

The Petroleum Technology Transfer Council (PTTC) is a unique not-for-profit network that focuses on transferring Exploration and Production (E&P) technology to the domestic oil and natural gas producing industry. PTTC connects producers, technology providers and innovators, academia, research and development (R&D) consortiums and governments. Local affordable workshops delivered by Regional Lead Organizations (RLOs), which are typically a university or geological survey, are a primary tool. PTTC also maintains a website network, issues a national newsletter, provides a column in a major trade publication, and exhibits at major industry events. It also encourages industry to ask technology-related questions, striving to findmore » relevant answers that will save questioners significant time. Working since late 1993, the PTTC network has a proven track record of providing industry with technology insights they can apply. Volunteers at the regional and national level provide key guidance regarding where to focus technical effort and help connect PTTC with industry. At historical funding levels, PTTC had been able to hold well more than 100 workshops per year, drawing 6,000+ attendees. As funding decreased in the early 2000s, the level of activity decreased and PTTC sought a merger with the American Association of Petroleum Geologists (AAPG), becoming an AAPG-managed organization at the start of FY08. This relationship with AAPG was terminated by mutual consent in May 2011 and PTTC once again operates independently. Chris Hall, California continued to serve as Chairman of the Board of Directors until December 2013. At the time PTTC reorganized into a RLO led organization with Mary Carr and Jeremy Viscomi as co-Executive Directors. Jerry Anderson became the Chairman of the PTTC Board of Directors and Chris Hall continues to serve on the Board. Workshop activity stabilized at 55-65 workshops per year averaging 3,100 attendees. FY14 represented the fifth year in a multi-year contract with the Department of Energy (DOE) for providing technology transfer services. This report summarizes activity and results during for five years, FY10 through FY14. In FY12 changes occurred in responsibilities of consultants serving HQ, because funding was reduced below the threshold level of $500,000 audits were no longer required and consultant time was reduced on the primary contract. Contracts for Permian Carbon Capture Utilization and Storage (CCUS) training, and providing tech transfer services to the Research Partnership to Secure Energy for America (RPSEA) provided work that enabled HQ to retain services of regular consultants. Both CCUS and RPSEA were five year contracts with PTTC, and providing services for these DOE funded contracts provided synergy for PTTC and the oil and gas industry. With further decreases in DOE funding the regions conducted workshops with no PTTC funding starting in June FY11. Since 2011 the number of workshops has declined from 79 in FY10 and FY11 to 49 in FY12, and risen to 54 in FY13 and 63 in FY14. The attendee's numbers dipped slightly below 3,000 per year in FY 10, FY12, and FY13, but rose to over 3,800 in FY 11 and 3105 in FY14. Quantitative accomplishments: PTTC has maintained its unique structure of a national organization working through Regional Lead Organizations (RLOs) to deliver local, affordable workshops. During the contract period PTTC consolidated from 10 to five regions to increase efficiency, and because no active RLO's would be maintained in the Central and Eastern Gulf Coast regions. RLO's for the regions are located at: Eastern - West Virginia University, (Illinois Geol. Survey., W. Michigan Univ. FY10-12); Midwest created in FY13 - Illinois Geological Survey, W. Michigan University; Midcontinent - University of Kansas, expanded to Houston, TX (2013-14); Rocky Mountain - Colorado School of Mines; Texas/SE New Mexico (FY10-FY11) - Bureau of Economic Geology, Univ. of Texas at Austin; West Coast - Conservation Committee of California O&G Producers.« less

FY2017 Energy Efficient Mobility Systems Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

During fiscal year 2017 (FY 2017), the U.S. Department of Energy (DOE) Vehicle Technologies Office (VTO) created the Energy Efficient Mobility Systems (EEMS) Program to understand the range of mobility futures that could result from these disruptive technologies and services, and to create solutions that improve mobility energy productivity, or the value derived from the transportation system per unit of energy consumed. Increases in mobility energy productivity result from improvements in the quality or output of the transportation system, and/or reductions in the energy used for transportation.

Building America Systems Integration Research Annual Report: FY 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gestwick, M.

2013-05-01

This document is the Building America FY2012 Annual Report, which includes an overview of the Building America Program activities and the work completed by the National Renewable Energy Laboratory and the Building America industry consortia (the Building America teams). The annual report summarizes major technical accomplishments and progress towards U.S. Department of Energy Building Technologies Program's multi-year goal of developing the systems innovations that enable risk-free, cost effective, reliable and durable efficiency solutions that reduce energy use by 30%-50% in both new and existing homes.

Electric and Hybrid Vehicles Program. Sixteenth annual report to Congress for fiscal year 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-08-01

This report describes the progress achieved in developing electric and hybrid vehicle technologies, beginning with highlights of recent accomplishments in FY 1992. Detailed descriptions are provided of program activities during FY 1992 in the areas of battery, fuel cell, and propulsion system development, and testing and evaluation of new technology in fleet site operations and in laboratories. This Annual Report also contains a status report on incentives and use of foreign components, as well as a list of publications resulting from the DOE program.

Physics of the Cosmos Program Annual Technology Report

NASA Technical Reports Server (NTRS)

Pham, Bruce Thai; Cardiff, Ann H.

2015-01-01

What's in this Report? What's New? This fifth Program Annual Technology Report (PATR) summarizes the Programs technology development activities for fiscal year (FY) 2015. The PATR serves four purposes.1. Summarize the technology gaps identified by the astrophysics community;2. Present the results of this years technology gap prioritization by the PCOS Technology Management Board (TMB);3. Report on newly funded PCOS Strategic Astrophysics Technology (SAT) projects; and4. Detail progress, current status, and activities planned for the coming year for all technologies supported by PCOS Supporting Research and Technology (SRT) funding in FY 2015. .

Human genome. 1993 Program report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-03-01

The purpose of this report is to update the Human Genome 1991-92 Program Report and provide new information on the DOE genome program to researchers, program managers, other government agencies, and the interested public. This FY 1993 supplement includes abstracts of 60 new or renewed projects and listings of 112 continuing and 28 completed projects. These two reports, taken together, present the most complete published view of the DOE Human Genome Program through FY 1993. Research is progressing rapidly toward 15-year goals of mapping and sequencing the DNA of each of the 24 different human chromosomes.

Notification: Evaluate EPA’s Progress Under Plan EJ 2014

EPA Pesticide Factsheets

Project #OPE-FY14-0040, June 9, 2014. The U.S. Environmental Protection Agency's (EPA's) Office of Inspector General (OIG) is starting preliminary research on the EPA's oversight of environmental justice activities.

Benchmarking of OEM Hybrid Electric Vehicles at NREL: Milestone Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kelly, K. J.; Rajagopalan, A.

2001-10-26

A milestone report that describes the NREL's progress and activities related to the DOE FY2001 Annual Operating Plan milestone entitled ''Benchmark 2 new production or pre-production hybrids with ADVISOR.''

Are Some Pre-Cataclysmic Variables also Post-Cataclysmic Variables?

NASA Astrophysics Data System (ADS)

Sarna, M. J.; Marks, P. B.; Smith, R. C.

1995-10-01

We propose an evolutionary scenario in which post-common-envelope binaries (PCEBs) with secondary component masses between 0.8 Msun and 1.2 M0 start semi-detached evolution almost immediately after the common-envelope (CE) phase. These systems detach due to unstable mass transfer when the secondary develops a thick convective envelope. The duration of the detached phase is a few times 108 yr, depending on the efficiency of magnetic braking and gravitational radiation. We suggest that some of the systems that have been classified as PCEBs may be in this stage of evolution and hence would be more realistically classified as pre-cataclysmic variables (PreCVs). We also propose an observational test based on measurements of the carbon and oxygen isotopic ratios from the infrared CO bands.

Defense Logistics Agency Green Products / Hazardous Minimization Warfighter Team: Helping the Warfighter Become Green!

DTIC Science & Technology

2010-06-01

Online Shopping Tool • Web self-service capability for the DOD • Sells both finished goods and services • Supports contracts written by DLA, GSA...month and over 750K items of content a month • FY08 Total Sales $835M; Green Sales $7.3M 11 DOD EMALL DOD’s Online Shopping Tool 1st Choice Support for

FY2016 Lightweight Materials Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Lightweight Materials research and development (R&D) area within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research focuses on addressing critical barriers to commercializing lightweight materials for passenger and commercial vehicles. This report describes the progress made on the research and development projects funded by the Lightweight Materials area.

AR and TD Fossil Energy Materials Program. Quarterly progress report for the period ending December 31, 1981

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1982-04-01

The ORNL Fossil Energy Materials Program Office compiles and issues this combined quarterly progress report from camera-ready copies submitted by each of the participating subcontractor organizations. This report of activities on the program is organized in accordance with a work breakdown structure defined in the AR and TD Fossil Energy Materials Program Plan for FY 1982-1986 in which projects are organized according to fossil energy technologies. This report is divided into parts and chapters with each part describing projects related to a particular fossil energy technology. Chapters within a part provide details of the various projects associated with that technology.more » We hope this series of AR and TD Fossil Energy Materials Program quarterly progress reports will aid in the dissemination of information developed on the program. Plans for the program will be issued annually. A draft of the program plan for FY 1982 to 1986 has been prepared and is in the review process. The implementation of these plans will be reflected by these quarterly progress reports, and this dissemination of information will bw augmented by topical or final reports as appropriate.« less

NASA/MSFC FY-81 Atmospheric Processes Research Review

NASA Technical Reports Server (NTRS)

Turner, R. E. (Compiler)

1981-01-01

Progress in ongoing research programs and future plans for satellite investigations into global weather, upper atmospheric phenomena, and severe storms and local weather are summarized. Principle investigators and publications since June 1980 are listed.

Uranium Detection - Technique Validation Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Colletti, Lisa Michelle; Garduno, Katherine; Lujan, Elmer J.

As a LANL activity for DOE/NNSA in support of SHINE Medical Technologies™ ‘Accelerator Technology’ we have been investigating the application of UV-vis spectroscopy for uranium analysis in solution. While the technique has been developed specifically for sulfate solutions, the proposed SHINE target solutions, it can be adapted to a range of different solution matrixes. The FY15 work scope incorporated technical development that would improve accuracy, specificity, linearity & range, precision & ruggedness, and comparative analysis. Significant progress was achieved throughout FY 15 addressing these technical challenges, as is summarized in this report. In addition, comparative analysis of unknown samples usingmore » the Davies-Gray titration technique highlighted the importance of controlling temperature during analysis (impacting both technique accuracy and linearity/range). To fully understand the impact of temperature, additional experimentation and data analyses were performed during FY16. The results from this FY15/FY16 work were presented in a detailed presentation, LA-UR-16-21310, and an update of this presentation is included with this short report summarizing the key findings. The technique is based on analysis of the most intense U(VI) absorbance band in the visible region of the uranium spectra in 1 M H 2SO 4, at λ max = 419.5 nm.« less

Analysis of Performance of Selected AFC, ATF Fuels, and Lanthanide Transport

DOE Office of Scientific and Technical Information (OSTI.GOV)

Unal, Cetin; Galloway, Jack D.

2015-09-29

We started to look at the performance of ATF concept in LWRs late in FY14 and finish our studies in FY15. The work has been presented in AFC review meetings, ICAPP and TOPFUEL conferences. The final version of the work is accepted for publication in Nuclear Engineering and Science Journal (NES). The copy of ICAPP and NES papers are attached separately to this document as our milestone deliverables. We made an important progress in the modeling of lanthanide transport in FY15. This work produced an ANS Winter Meeting paper and GLOBAL 2015 paper. GLOBAL 2015 paper is also attached asmore » deliverable of FY15. The work on the lanthanide transport is preliminary. We are exploring other potential mechanisms, in addition to “liquid-like” diffusion mechanisms, proposed by Robert Mariani [1] before we analyze data that will be taken by Ohio State University. This year, we concentrate on developing diffusion kernels and principles of modeling. Next year, this work will continue and analyze the Ohio State data and develop approaches to solve multicomponent diffusion. In addition to three papers we attached to this report, we have done some research on coupling and the development of gas release model for metallic fuels in FY15. They are also preliminary in nature; therefore, we give the summary of what we found rather than an extended report that will be done in FY16.« less

Notification: Municipal Sewer Systems - Consent Decree Progress and Challenges

EPA Pesticide Factsheets

Project #OPE-FY14-0045, August 6, 2014. The EPA OIG plans to begin preliminary research on the EPA's ongoing enforcement initiative focused on keeping raw sewage and contaminated stormwater out of our nation's waters.

2005 International Infantry and Joint Services Small Arms Systems Annual Symposium Exhibition and Firing Demonstration

DTIC Science & Technology

2005-05-19

Noon Awards Luncheon Chinn Award Presentation Mr. Richard Audette, Chinn Award Recipient, 2005 Presented by Mr. Joel Goldman Hathcock ...Award Presentation Mr. Christopher P. Mitternight, Hathcock Award Recipient, 2005 Presented by Mr. Charles Buxton 1:30 - 5 PM Concurrent Sessions...Schedule) 1Q/FY08 POC: James Hahn / 973-724-2117 PM: Chris Grassano / 973-724-5246 Technology Supercapacitor based power

Evaluation of a Non-Invasive Alternative Glucose Monitor System in Patients with Diabetes Mellitus

DTIC Science & Technology

2008-01-07

Diabetes Mellitus New Protocol Title: Evaluation of a Non-Invasive Alternative Glucose Monitor System in Patients with Diabetes Mellitus PRINCIPAL...Invasive Alternative Glucose Monitor System in Patients with Diabetes Mellitus 5b. GRANT NUMBER Coop Agreement # 05216002 5c. PROGRAM ELEMENT NUMBER...Flexible Medical Systems was approved by the Department of Clinical Investigation at WRAMC in January 2008. FY08 AAMTI funding will support the

Joint Service Chemical and Biological Defense Program FY 08-09 Overview

DTIC Science & Technology

2007-10-01

of human plasma-derived butyrylcholinesterase Electronmicrograph of bacillus spores adhering to cell membrane processes Jo i n t Se rv i c e ch e m i...human performance within CB-protective systems. Carbon monolith for electro-swing adsorption Bacillus globigii spores collecting on an...integrated with the ship’s heating, ventilation, and air-conditioning ( HVAC ) systems and provides a filter air supply air for overpressurization of

Active Time-Domain Reflectometry for Unattended Safeguards Systems FY15 Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tedeschi, Jonathan R.; Smith, Leon E.; Moore, David E.

2015-09-01

The International Atomic Energy Agency (IAEA) continues to expand its use of unattended measurement systems. An increasing number of systems and an expanding family of instruments create challenges in terms of deployment efficiency and the implementation of data authentication measures. In collaboration with the IAEA, tamper-indicating measures to address data-transmission authentication challenges with unattended safeguards systems are under investigation. Pacific Northwest National Laboratory (PNNL) is studying the viability of active time-domain reflectometry (TDR) along two parallel but interconnected paths: (1) swept-frequency TDR as the highly flexible, laboratory gold standard to which field-deployable options can be compared, and (2) a low-costmore » commercially available spread-spectrum TDR technology as one option for field implementation. This report describes PNNL’s FY15 progress in the viability study including: an overview of the TDR methods under investigation; description of the testing configurations and mock tampering scenarios; results from a preliminary sensitivity comparison of the two TDR methods; demonstration of a quantitative metric for estimating field performance that acknowledges the need for high detection probability while minimizing false alarms. FY15 progress reported here sets the stage for a rigorous comparison of the candidate TDR methods, over a range of deployment scenarios and perturbing effects typical of IAEA unattended monitoring systems.« less

Optimization for energy efficiency of underground building envelope thermal performance in different climate zones of China

NASA Astrophysics Data System (ADS)

Shi, Luyang; Liu, Jing; Zhang, Huibo

2017-11-01

The object of this article is to investigate the influence of thermal performance of envelopes in shallow-buried buildings on energy consumption for different climate zones of China. For the purpose of this study, an effective building energy simulation tool (DeST) developed by Tsinghua University was chosen to model the heat transfer in underground buildings. Based on the simulative results, energy consumption for heating and cooling for the whole year was obtained. The results showed that the relationship between energy consumption and U-value of envelopes for underground buildings is different compared with above-ground buildings: improving thermal performance of exterior walls cannot reduce energy consumption, on the contrary, may result in more energy cost. Besides, it is can be derived that optimized U-values of underground building envelopes vary with climate zones of China in this study. For severe cold climate zone, the optimized U-value of underground building envelopes is 0.8W/(m2·K); for cold climate zone, the optimized U-value is 1.5W/(m2·K); for warm climate zone, the U-value is 2.0W/(m2·K).

Metal hydride reasearch and development program at Brookhaven National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, J.R.; Reilly, J.J.

1978-01-01

A progress report is presented covering work performed in the hydrogen materials development program at Brookhaven National Laboratory (BNL) for FY78 which encompasses the time period from October 1, 1977 through September 30, 1978. The subjects to be discussed here concern properties of importance in the utilization of metal hydrides as energy storage media. Most of the areas of research were initiated prior to FY78, however all of the results contained in this manuscript were obtained during the aforementioned period of time. The following subjects will be discussed: the properties of ferro-titanium and chrome-titanium alloy hydrides.

Annual Progress Report - Fiscal Year 1982

DTIC Science & Technology

1982-10-01

activity . A published method developed in our laboratory for determining tne antibacterial activity of mouse peritoneal phagocytes in vivo (1) has been...EDITOR’S NOTE This FY 1982 Annual Progress report is a general review of research activities of the U. S. Army Medical Research Institute of Infectious...years earlier. Passive immunization, active immunization using killed or living attenuated whole agent, or immunization with sub-unit antigens achieved

Joint Strategic Oversight Plan for Afghanistan Reconstruction FY13

DTIC Science & Technology

2012-07-01

programs within its ministries and made progress in deterring corruption by investi­ gating, prosecuting, sanctioning or removing corrupt officials from...within its ministries and made progress in deterring corruption by investigat­ ing, prosecuting, sanctioning or removing corrupt officials from office...of oversight and Lodin’s credibility. • Department of Justice and the Justice Sector Support Program continued their suspension of training the

Nuclear Technology Division annual progress report for period ending June 30, 1972

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1972-10-01

This document is a report of progress on technical programs of the Nuclear Technology,Division of Aerojet Nuclear Company for FY 72 ending June 30, 1972. It contains abstracts or expansions of abstracts of papers which have been published within the year. In these cases, preprints or reprints of the articles available. Results of work in progress are also reported; since this work is of a preliminary nature, the authors should be contacted before including any reference to these works in other publications.

NASA Microgravity Science and Applications Program

NASA Technical Reports Server (NTRS)

1992-01-01

Key elements of the microgravity research program as conducted by the Microgravity Science and Applications Division (MSAD) within the Office of Space Science and Applications (OSSA) during fiscal year (FY) 1992 are described. This NASA funded program supported investigators from the university, industry, and government research communities. The program's goals, the approach taken to achieve those goals, and the resources that were available are summarized. It provides a 'snapshot' of the Program's status at the end of FY 1992 and reviews highlights and progress in the ground and flight-based research during the year. It also describes four major space missions that flew during FY 1992, the advanced technology development (ATD) activities, and the plans to use the research potential of Space Station Freedom and other advanced carriers. The MSAD program structure encompassed five research areas: (1) Biotechnology, (2) Combustion Science, (3) Fluid Physics, (4) Materials Science, and (5) Benchmark Physics.

Area G perimeter surface-soil and single-stage water sampling: Environmental surveillance for fiscal year 95. Progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Childs, M.; Conrad, R.

1997-09-01

ESH-19 personnel collected soil and single-stage water samples around the perimeter of Area G at Los Alamos National Laboratory (LANL) during FY 95 to characterize possible radionuclide movement out of Area G through surface water and entrained sediment runoff. Soil samples were analyzed for tritium, total uranium, isotopic plutonium, americium-241, and cesium-137. The single-stage water samples were analyzed for tritium and plutonium isotopes. All radiochemical data was compared with analogous samples collected during FY 93 and 94 and reported in LA-12986 and LA-13165-PR. Six surface soils were also submitted for metal analyses. These data were included with similar data generatedmore » for soil samples collected during FY 94 and compared with metals in background samples collected at the Area G expansion area.« less

Photovoltaic Subcontract Program. Annual report, FY 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-03-01

This report summarizes the fiscal year (FY) 1992 progress of the subcontracted photovoltaic (PV) research and development (R&D) performed under the Photovoltaic Advanced Research and Development Project at the National Renewable Energy Laboratory (NREL)-formerly the Solar Energy Research Institute (SERI). The mission of the national PV program is to develop PV technology for large-scale generation of economically competitive electric power in the United States. The technical sections of the report cover the main areas of the subcontract program: the Crystalline Materials and Advanced Concepts project, the Polycrystalline Thin Films project, Amorphous Silicon Research project, the Photovoltaic Manufacturing Technology (PVMaT) project,more » PV Module and System Performance and Engineering project, and the PV Analysis and Applications Development project. Technical summaries of each of the subcontracted programs provide a discussion of approaches, major accomplishments in FY 1992, and future research directions.« less

Chemistry and Materials Science progress report, FY 1994. Revision 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-01-01

Thrust areas of the weapons-supporting research include surface science, fundamentals of the physics and processing of metals, energetic materials, etc. The laboratory directed R and D include director`s initiatives, individual projects, and transactinium science studies.

Community-Scale Air Toxics Ambient Monitoring Grant - Closed Announcement FY 2015

EPA Pesticide Factsheets

Grant to fund projects designed to assist state, local and tribal communities in identifying air toxics sources, characterizing the degree and extent of local-scale air toxics problems, tracking progress of air toxics reduction activities, etc.

DOT Performance Plan FY 1999

DOT National Transportation Integrated Search

1999-01-01

The Department of Transportation Performance Plan is a companion piece to the DOT Strategic Plan and to the DOT Fiscal Year 1999 Budget Request. The Performance Plan defines those performance indicators and goals that will be used to mark progress to...

UAS Integration in the NAS FY15 Annual Review

NASA Technical Reports Server (NTRS)

Grindle, Laurie; Randall, Debra; Hackenburg, Davis

2015-01-01

This presentation gives insight into the research activities and efforts being executed in order to integrate unmanned aircraft systems into the national airspace system. This briefing is to inform others of the UAS-NAS progress and future directions.

FY2014 National Clean Diesel Funding Assistance (Diesel Emissions Reduction Act) Programmatic Terms and Conditions

EPA Pesticide Factsheets

EPA will provide substantial involvement in the form of technical assistance, development ofoutputs, and oversight. EPA and the recipient in program content, review of project progress, and quantification and reporting of results.

Advancing Green Remediation Cleanup Practices in the Air Force

DTIC Science & Technology

2011-05-12

381 Remedial Systems in Operation * Energy Intensive (38%) Low Energy/Passive (48%) Other *Based on FY08 EDITT System Inventory as of 15 March...requirements over long periods, systems which do not require continuous operation  Help ER RPMs decide on use of renewable energy  Simple enough to be used...Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware

FY08 In-House Laboratory Independent Research (ILIR) and Independent Applied Research (IAR) Annual Reports

DTIC Science & Technology

2009-01-01

body (SUBOFF) in rotation, NSWCCD-50- TR-2008/030. Carneal, J., S. Percival, A. Etebari, P. Atsavapranee, T. Farabee, M. Goody, Optical bubble...Coursekeeping Funding Year: Third Principal Investigator: Dr. Ray-Qing Lin, Code: 5500, NSWC Carderock Phone: 301-227-3945, E-mail Address...accepted for publications Lin, R-Q., and W. Kuang, , Solid- body motion in fully nonlinear ship motion model, submitted to J. Marine Science and

78 FR 15960 - Request for Information on the FY 2013-2018 Strategic Plan for the Office of Disease Prevention

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-13

... injuries and the progression of asymptomatic disease. Prevention research targets biology and genetics, individual behavior, factors in the social and physical environments, and health services; and it informs and...

UAS Integration in the NAS Project - FY 14 Annual Review

NASA Technical Reports Server (NTRS)

Grindle, Laurie; Randall, Debra; Hackenberg, Davis

2014-01-01

This briefing gives insight into the research activities and efforts being executed in order to integrate unmanned aircraft systems into the national airspace system. This briefing is to inform others of the UAS-NAS Projects progress and future directions.

FY2014 National Clean Diesel Funding Assistance (Diesel Emissions Reduction Act) Programmatic Terms and Conditions

EPA Pesticide Factsheets

Substantial federal involvement will take the form of monitoring the project by EPA, participation and collaboration between EPA and the recipient in program content, review of project progress, and quantification and reporting ofresults.

FY2009 Annual Progress Report for Energy Storage Research and Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2010-01-19

The energy storage research and development effort within the VT Program is responsible for researching and improving advanced batteries and ultracapacitors for a wide range of vehicle applications, including HEVs, PHEVs, EVs, and fuel cell vehicles (FCVs).

Annual Progress Report FY-92. Volume 2

DTIC Science & Technology

1992-01-01

OBJECTIVE To measure the effect of methotrexate on interleukin-l ( IL - 1 ) induced ICAN-l expression in cultured human fibroblasts and adenocarcinoma cells...SUMMARY SHEET TITLE: Effect of IL - 1 on Glucocorticoid Inhibition of Wound Healing KEYWORDS: IL - 1 , wound healing PRINCIPAL INVESTIGATOR: Schoenfeld, Phil CPT...PROGRESS Cultured cells were incubated with IL -l to stimulate ICAM-l expression. In general, the cells responded well. ICAM- 1 was readily detectable

ELECTRON MICROSCOPY OF MITOSIS IN AMEBAE

PubMed Central

Roth, L. E.

1967-01-01

The mitotic apparatus (MA) of the giant ameba, Chaos carolinensis, has characteristic sequences of microtubule arrays and deployment of nuclear envelope fragments. If mitotic organisms are subjected to 2°C for 5 min, the MA microtubules are completely degraded, and the envelope fragments are released from the chromosomes which remain condensed but lose their metaphase-plate orientation. On warming, microtubules reform but show partial loss of their parallel alignment; displacement of the envelope fragments persists or is increased by microtubule reformation. This study demonstrates that cooling causes destruction of microtubules and intermicrotubular cross-bonds and further shows that such controlled dissolution and reformation can provide an in vivo test sequence for studies on the effects of inhibitor-compounds on microtubule subunit aggregation. Urea, at the comparatively low concentration of 0.8 M, inhibited reformation following cooling and rewarming but was ineffective in altering microtubules that had formed before treatment. PMID:6040537

Final Report (O1-ERD-051) Dynamic InSAR: Imaging Seismic Waves Remotely from Space

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vincent, P; Rodgers, A; Dodge, D

2003-02-07

The purpose of this LDRD project was to determine the feasibility of using InSAR (interferometric synthetic aperture radar) to image seismic waves remotely from space. If shown to be feasible, the long-term goal of this project would be to influence future SAR satellite missions and airborne SAR platforms to include a this new capability. This final report summarizes the accomplishments of the originally-planned 2-year project that was cut short to 1 year plus 2 months due to a funding priority change that occurred in the aftermath of the September 11th tragedy. The LDRD-ER project ''Dynamic InSAR: Imaging Seismic Waves frommore » Space'' (01-ERD-051) began in October, (FY01) and ended in December (FY02). Consequently, most of the results and conclusions for this project are represented in the FY0l Annual Report. Nonetheless, additional conclusions and insights regarding the progress of this work are included in this report. In should be noted that this work was restarted and received additional funding under the NA-22 DOE Nonproliferation Program in FY03.« less

Development of tools and techniques for momentum compression of fast rare isotopes

DOE Office of Scientific and Technical Information (OSTI.GOV)

David J. Morrissey; Bradley M. Sherrill; Oleg Tarasov

2010-11-21

As part of our past research and development work, we have created and developed the LISE++ simulation code [Tar04, Tar08]. The LISE++ package was significantly extended with the addition of a Monte Carlo option that includes an option for calculating ion trajectories using a Taylor-series expansion up to fifth order, and implementation of the MOTER Monte Carlo code [Kow87] for ray tracing of the ions into the suite of LISE++ codes. The MOTER code was rewritten from FORTRAN into C++ and transported to the MS-Windows operating system. Extensive work went into the creation of a user-friendly interface for the code.more » An example of the graphical user interface created for the MOTER code is shown in the left panel of Figure 1 and the results of a typical calculation for the trajectories of particles that pass through the A1900 fragment separator are shown in the right panel. The MOTER code is presently included as part of the LISE++ package for downloading without restriction by the worldwide community. The LISE++ was extensively developed and generalized to apply to any projectile fragment separator during the early phase of this grant. In addition to the inclusion of the MOTER code, other important additions to the LISE++ code made during FY08/FY09 are listed. The LISE++ is distributed over the web (http://groups.nscl.msu.edu/lise ) and is available without charge to anyone by anonymous download, thus, the number of individual users is not recorded. The number of 'hits' on the servers that provide the LISE++ code is shown in Figure 3 for the last eight calendar years (left panel) along with the country from the IP address (right panel). The data show an increase in web-activity with the release of the new version of the program during the grant period and a worldwide impact. An important part of the proposed work carried out during FY07, FY08 and FY09 by a graduate student in the MSU Physics program was to benchmark the codes by comparison of detailed measurements to the LISE++ predictions. A large data set was obtained for fission fragments from the reaction of 238U ions at 81 MeV/u in a 92 mg/cm2 beryllium target with the A1900 projectile fragment separator. The data were analyzed and form the bulk of a Ph.D. dissertation that is nearing completion. The rich data set provides a number of benchmarks for the improved LISE++ code and only a few examples can be shown here. The primary information obtained from the measurements is the yield of the products as a function of mass, charge and momentum. Examples of the momentum distributions of individually identified fragments can be seen in Figures 2 and 4 along with comparisons to the predicted distributions. The agreement is remarkably good and indicates the general validity of the model of the nuclear reactions producing these fragments and of the higher order transmission calculations in the LISE++ code. The momentum distributions were integrated to provide the cross sections for the individual isotopes. As shown in Figure 5, there is good agreement with the model predictions although the observed cross sections are a factor of five or so higher in this case. Other comparisons of measured production cross sections from abrasion-fission reactions have been published by our group working at the NSCL during this period [Fol09] and through our collaboration with Japanese researchers working at RIKEN with the BigRIPS separator [Ohn08, Ohn10]. The agreement of the model predictions with the data obtained with two different fragment separators is very good and indicates the usefulness of the new LISE++ code.« less

Office of Inspector General audit report on Project Hanford management contract costs and performance

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-11-01

On August 6, 1996, the Richland Operations Office (Richland) awarded the Project Hanford Management Contract (Management Contract) to Fluor Daniel Hanford, Inc. (Fluor Daniel). This performance-based, 5-year contract to support cleanup of the Department of Energy`s (DOE) Hanford Site (Hanford) contained performance goals or expectations related to the stabilization, transition, and diversification of the Tri-Cities` economy near Hanford in southeastern Washington. One of these economic goals was that Fluor Daniel and its major subcontractors would help generate 3,000 new, non-Hanford, private sector jobs that would help stabilize and diversify the Tri-Cities` economy. The contract specifically called for Fluor Daniel tomore » help generate 200 jobs, establish an investment fund, and bring 6 new growth-oriented enterprise companies to the Tri-Cities by the end of Fiscal Year (FY) 1997. The objective of the audit was to determine whether Richland was making adequate progress in stabilizing and diversifying the economy of the Tri-Cities by creating 3,000 new, non-Hanford jobs within 5 years. Accordingly, the author examined the progress made in FY 1997, which was the first year of the Management Contract. Richland and Fluor Daniel are at risk of not meeting the Management Contract`s goals of stabilizing and diversifying the economy of the Tri-Cities because most of the new jobs created during FY 1997 were not comparable to Hanford jobs and, thus, may not sustain long-term economic goals. Therefore, Fluor Daniel has not met its expectations in the first year and is not making adequate progress toward meeting the Management Contract`s overall economic goals.« less

Columbia River Basin Fish and Wildlife Program Annual Implementation Work Plan for Fiscal Year 1990.

DOE Office of Scientific and Technical Information (OSTI.GOV)

United States. Bonneville Power Administration; Northwest Power Planning Council; Columbia Basin Fish and Wildlife Authority

1990-01-01

The Columbia River Basin Fish and Wildlife Program (Program) was developed by the Northwest Power Planning Council (Council) in accordance with Public Law 96-501, the Pacific Northwest Electric Power Planning and Conservation Act (Act). The purpose of the Program is to guide the Bonneville Power Administration (BPA) and other Federal agencies in carrying out their responsibilities to protect, mitigate, and enhance fish and wildlife of the Columbia River Basin. The Act explicitly gives BPA the authority and responsibility to use the BPA fund for these ends, to the extent that fish and wildlife are affected by the development and operationmore » of hydroelectric generation in the Columbia River Basin. This document presents BPA's plans for implementing the Program during Fiscal Year (FY) 1990. The Columbia River Basin Fish and Wildlife Program Annual Implementation Work Plan (AIWP) reflects the primary goals of the Council's Action Plan (Section 1400 of the Program): to provide a solid, timely, and focused basis for budgeting and planning. In addition, the AIWP provides a means to judge progress and the success of Program implementation. The FY 1990 AIWP also follows the outline developed by the Policy Review Group (PRG) during Step 1 of initial cycle of the Implementation Planning Process (IPP), which is described in Section III. A number of new FY 1990 projects were still under review by the PRG as the AIWP went to press. These projects have been noted in Table 2, New FY 1990 Program Projects, and in the text of the AIWP. This AIWP has been organized and written to meet the specific needs of Program Action Items 10.1-10.3. The AIWP includes schedules with key milestones for FY 1990 and beyond, and addresses the Action Items assigned to BPA in Section 1400 of the 1987 Program. All BPA-funded Program projects discussed in the FY 1990 AIWP are listed in Tables 1 and 2 according to their status as of September 30, 1989. Table 1 (pp. 3-14) lists completed, ongoing, and deferred projects. Table 2 (pp. 15-18) lists all projects which BPA plans to fund as ''new'' projects in FY 1990. ''Ongoing'' status indicates that the project started in FY 1989 or before, and that it is expected to continue in FY 1990. ''Deferred'' means that BPA implementation has been postponed to FY 1991 or later. ''Completed'' indicates completion during FY 1989. ''New'' denotes projects that BPA plans to start in FY 1990. One new FY 1990 project was included in the draft FY 1990 AIWP as a ''conditional'' project, as a result of PRG recommendations at the May 25, 1989, PRG meeting. If specified conditions are met, BPA will begin to implement the project in FY 1990. Section VII describes BPA's non-Program, internal support projects. These projects were not subject to review by the PRG and have been included in the AIWP to help the PRG and the public to better understand what BPA is doing.« less

Annual Research Progress Report, Fiscal Year 1980

DTIC Science & Technology

1980-10-01

AITE -sd Subtitle) 3. TYPE OF REPORT & PERIOD COVERED 4UAL RESEARCH pROGRESS REPORT ____________ANNUAL - FY 80 S- -- 4. PERFORMING ORG. REPORT NUNSER 7...AUHON) 4F e. CONTRACT OR GRANT NUMBER(e)’ JAMES DERSON, JR , M.D. 10. PERFORMING ORGANIZATION NAME AND ADDRESS 10- PROGRAM ELEMENT, PROJECT, TASK...and DOD) regulations governing human, animal and even in vitro research, the declining number of academic physicians serving as role models and

Lawrence Berkeley National Laboratory 2016 Annual Financial Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, Kim, P.; Williams, Kim, P.

FY2016 was a year of significant change and progress at Berkeley Lab. In March, Laboratory Director Michael Witherell assumed his new role when former Lab Director Paul Alivisatos became Vice Chancellor for Research at UC Berkeley. Dr. Witherell has solidified the Lab’s strategy, with a focus on long term science and technology priorities. Large-scale science efforts continued to expand at the Lab, including the Dark Energy Spectroscopic Instrument now heading towards construction, and the LUX-ZEPLIN dark matter detector to be built underground in South Dakota. Another proposed project, the Advanced Light Source-Upgrade, was given preliminary approval and will be themore » Lab’s largest scientific investment in years. Construction of the Integrative Genomics Building began, and will bring together researchers from the Lab’s Joint Genome Institute, now based in Walnut Creek, and the Systems Biology Knowledgebase (K-Base) under one roof. Investment in the Lab’s infrastructure also continues, informed by the Lab’s Infrastructure Strategic Plan. Another important focus is on developing the next generation of scientists with the talent and diversity needed to sustain Berkeley Lab’s scientific leadership and mission contributions to DOE and the Nation. Berkeley Lab received $897.5M in new FY2016 funding, a 12.5% increase over FY2015, for both programmatic and infrastructure activities. While the Laboratory experienced a substantial increase in funding, it was accompanied by only a modest increase in spending, as areas of growth were partially offset by the completion of several major efforts in FY2015. FY2016 costs were $826.9M, an increase of 1.9% over FY2015. Similar to the prior year, the indirect-funded Operations units worked with generally flat budgets to yield more funding for strategic needs. A key challenge for Berkeley Lab continues to be achieving the best balance to fund essential investments, deliver highly effective operational mission support and remain cost-competitive. Through a comprehensive approach to prioritize competing needs, the Lab ended the year in a favorable financial position. The Office of the Chief Financial Officer (OCFO) played a key role in providing analysis and decision support to Executive Leadership, enabling the Lab to enhance its financial management strategies. In FY2016, the OCFO updated its analytic approaches and models to enhance long term financial projections under various funding and investment scenarios, and to assess total cost of ownership for major proposed investments. These improvements provided the new Lab Director and Senior Leadership with more comprehensive information and analytic support for planning and prioritization efforts. Within the OCFO, we focused on core operations and key initiatives defined in our OCFO Strategic Roadmap. The Lab’s Financial System transitioned from stabilization to optimization, with a focus on expanding the financial reporting capabilities considerably. We completed implementation of the eCommerce platform, achieving a notable outcome for the Lab in close partnership with DOE’s Office of Science. In other accomplishments, we launched a financial literacy program to enable Lab managers and staff to understand and execute their financial management and stewardship responsibilities more effectively; made substantial progress in enhancing our Field Finance model that provides financial support to client divisions and areas; developed a business process governance model to define OCFO business processes, clarify roles, and strengthen service delivery; and implemented a Partners in Leadership training program to build leadership capacity among our staff. We completed a ‘refresh’ of our Strategic Roadmap, which now defines our priorities for FY2017-FY2019. As a part of this effort, we made a subtle but important change to the OCFO mission statement to call out the Lab’s research and stewardship mission to sustain the Lab’s science and technology capabilities now and into the future. Berkeley Lab’s FY2016 progress on all fronts - scientific, operations, and financial management – position the Lab to continue bringing science solutions to the world as we charge into the 21st Century.« less

2009 Department of Defense HIV/AIDS Prevention Program (DHAPP)

DTIC Science & Technology

2010-05-01

FY08 to assess the program’s effectiveness. MEASURES OF EFFECTIVENESS Pretest and posttests have been developed with the expertise of the physicians...among the trainees. Pretest scores ranged from 55.0% to 80.0%, while posttest scores ranged from 72.5% to 82.5%, making it clear that it was a...valuable training for all participants. The average pretest score ranged from approximately 67.5% to a posttest average of 79.0%, showing clear

Ground Vehicle Power and Mobility Overview

DTIC Science & Technology

2007-05-30

Program Li-Ion Phosphate (LFP) Cathode Materials Large Format Li-Ion Prismatic Cells and Modules with Integrated Liquid Cooling Integrated Prototype...using porous graphitic material3 4 5 8 5 6 60 W-hr/kg 80-120 W/kg Low Cycle Life LFP cathode Safer Less energetic materials ~ ~ Power Cell 85-120...Thermal Runaway Study Zebra Battery NaNiCl2 (FY08 ATO) Advanced Lead Acid LiFePO4 Cathode Prismatic Lithium-ion batteries and Integrated Liquid Cooling

FY08 DRMRP Clinical Trial: Strengthening Pathways to PTSD Recovery Using Systems-Level Intervention

DTIC Science & Technology

2015-09-01

telephone cognitive-behavioral therapy , continuous RN nurse care management, and computer-automated care management support. Both arms can refer patients... physically occurring at the study sites. These closure reports were approved by the local DDEAMC and lead WRNMMC IRBs in May 2015 and by HRPO in June... physical symptom burden (as measured by the PHQ-15), improved mental health functioning (as measured by the SF-12 mental component), but no changes for

Columbia River Basin Fish and Wildlife Program Annual Implementation Work Plan for Fiscal Year 1992.

DOE Office of Scientific and Technical Information (OSTI.GOV)

United States. Bonneville Power Administration; Northwest Power Planning Council; Columbia Basin Fish and Wildlife Authority

1991-09-01

The Columbia River Basin Fish and Wildlife Program (Program) was developed by the Northwest Power Planning Council (Council) in accordance with Public Law 96-501, the Pacific Northwest Electric Power Planning and Conservation Act (Act). The purpose of the Program is to guide the Bonneville Power Administration (BPA) and other Federal agencies in carrying out their responsibilities to protect, mitigate, and enhance fish and wildlife of the Columbia River Basin. The Act explicitly gives BPA the authority and responsibility to use the BPA fund for these ends, to the extent that fish and wildlife are affected by the development and operationmore » of hydroelectric generation in the Columbia River Basin. The Columbia River Basin Fish and Wildlife Program Annual Implementation Work Plan (AIWP) presents BPA's plans for implementing the Program during Fiscal Year (FY) 1992. The AIWP reflects the primary goals of the Council's Action Plan (Section 1400 of the Program): to provide a solid, timely, and focused basis for budgeting and planning. In addition, the AIWP provides a means to judge the progress and the success of Program implementation. The AIWP is based on the outline developed by the Policy Review Group (PRG) during Step 1 of the annual cycle of the Implementation Planning Process (IPP), which is described in Section III. This AIWP has been organized and written to meet the specific needs of Program Action Items 10.1-10.3. The AIWP includes schedules with key milestones for FY 1992 and beyond, and addresses the Action Items assigned to BPA in Section 1400 of the 1987 Program and in subsequent amendments. All Program projects discussed in the AIWP are listed in Tables 1 and 2 according to their status as of May 21, 1991. Table 1 (pp. 3-14) lists completed, ongoing, and deferred projects. Table 2 (pp. 15-16) lists FY 1992 new-start projects. ''Ongoing'' status indicates that the project started in FY 1991 or before and that it is expected to continue through part or all of FY 1992. ''Deferred'' means that BPA implementation has been postponed to FY 1993 or later. ''Completed'' indicates completion during FY 1991. ''New'' denotes projects planned for BPA implementation in FY 1992. A number of projects are expected to begin in late FY 1991 and have been listed in Table 1 of the AIWP as ''Projected FY '91 Starts,'' based on their projected start dates. Several other projects are expected to end in late FY 1991. These projects have been listed in Table 1 as ''Projected FY '91 Completions,'' based on their projected completion dates.« less

Discrete Fracture Network Modeling and Simulation of Subsurface Transport for the Topopah Springs and Lava Flow Aquifers at Pahute Mesa, FY 15 Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Makedonska, Nataliia; Kwicklis, Edward Michael; Birdsell, Kay Hanson

This progress report for fiscal year 2015 (FY15) describes the development of discrete fracture network (DFN) models for Pahute Mesa. DFN models will be used to upscale parameters for simulations of subsurface flow and transport in fractured media in Pahute Mesa. The research focuses on modeling of groundwater flow and contaminant transport using DFNs generated according to fracture characteristics observed in the Topopah Spring Aquifer (TSA) and the Lava Flow Aquifer (LFA). This work will improve the representation of radionuclide transport processes in large-scale, regulatory-focused models with a view to reduce pessimistic bounding approximations and provide more realistic contaminant boundarymore » calculations that can be used to describe the future extent of contaminated groundwater. Our goal is to refine a modeling approach that can translate parameters to larger-scale models that account for local-scale flow and transport processes, which tend to attenuate migration.« less

Annual Report: Photovoltaic Subcontract Program FY 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Summers, K. A.

1991-03-01

This report summarizes the progress of the Photovoltaic (PV) Subcontract Program of the Solar Energy Research Institute (SERI) from October 1, 1989 through September 30, 1990. The PV Subcontract Program is responsible for managing the subcontracted portion of SERI's PV Advanced Research and Development Project. In fiscal year 1990, this included more than 54 subcontracts with a total annualized funding of approximately $11.9 million. Approximately two-thirds of the subcontracts were with universities at a total funding of nearly $3.3 million. The six technical sections of the report cover the main areas of the subcontract program: the Amorphous Silicon Research Project,more » Polycrystalline Thin Films, Crystalline Silicon Materials Research, High-Efficiency Concepts, the New Ideas Program, and the University Participation Program. Technical summaries of each of the subcontracted programs provide a discussion of approaches, major accomplishments in FY 1990, and future research directions. Another section introduces the PVMaT project and reports on its progress.« less

Secure & Restore Critical Fisheries Habitat, Flathead Subbasin, FY2008 Annual Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

DuCharme, Lynn; Tohtz, Joel

The construction of Hungry Horse Dam inundated 125 km of adfluvial trout habitat in the South Fork of the Flathead River and its tributaries, impacting natural fish reproduction and rearing. Rapid residential and commercial growth in the Flathead Watershed now threaten the best remaining habitats and restrict our opportunities to offset natural resource losses. Hydropower development and other land disturbances caused severe declines in the range and abundance of our focal resident fish species, bull trout and westslope cutthroat trout. Bull trout were listed as threatened in 1998 under the Endangered Species Act and westslope cutthroat were petitioned for listingmore » under ESA. Westslope cutthroat are a species of special concern in Montana and a species of special consideration by the Confederated Salish and Kootenai Tribes. The Secure & Protect Fisheries Habitat project follows the logical progression towards habitat restoration outlined in the Hungry Horse Dam Fisheries Mitigation Implementation Plan approved by the NWPPC in 1993. This project is also consistent with the 2000 Fish and Wildlife Program and the Flathead River Subbasin Plan that identifies the protection of habitats for these populations as one of the most critical needs in the subbasin and directs actions to offset habitat losses. The Flathead basin is one of the fastest growing human population centers in Montana. Riparian habitats are being rapidly developed and subdivided, causing habitat degradation and altering ecosystem functions. Remaining critical habitats in the Flathead Watershed need to be purchased or protected with conservation easements if westslope cutthroat and bull trout are to persist and expand within the subbasin. In addition, habitats degraded by past land uses need to be restored to maximize the value of remaining habitats and offset losses caused by the construction of Hungry Horse Dam. Securing and restoring remaining riparian habitat will benefit fish by shading and moderating water temperatures, stabilizing banks and protecting the integrity of channel dimension, improving woody debris recruitment for in-channel habitat features, producing terrestrial insects and leaf litter for recruitment to the stream, and helping to accommodate and attenuate flood flows. The purpose of this project is to work with willing landowners to protect the best remaining habitats in the Flathead subbasin as identified in the Flathead River Subbasin Plan. The target areas for land protection activities follow the priorities established in the Flathead subbasin plan and include: (1) Class 1 waters as identified in the Flathead River Subbasin Plan; (2) Class 2 watersheds as identified in the Flathead River Subbasin Plan; and (3) 'Offsite mitigation' defined as those Class 1 and Class 2 watersheds that lack connectivity to the mainstem Flathead River or Flathead Lake. This program focuses on conserving the highest quality or most important riparian or fisheries habitat areas consistent with program criteria. The success of our efforts is subject to a property's actual availability and individual landowner negotiations. The program is guided using biological and project-based criteria that reflect not only the priority needs established in the Flathead subbasin plan, but also such factors as cost, credits, threats, and partners. The implementation of this project requires both an expense and a capital budget to allow work to be completed. This report addresses accomplishments under both budgets during FY08 as the two budgets are interrelated. The expense budget provided pre-acquisition funding to conduct activities such as surveys, appraisals, staff support, etc. The capital budget was used to purchase the interest in each parcel including closing costs. Both the pre-acquisition contract funds and the capital funds used to purchase fee title or conservation easements were spent in accordance with the terms negotiated within the FY08 through FY09 MOA between the Tribes, State, and BPA. In FY08, the focus of this project was to pursue all possible properties targeted by the Tribes and Montana Fish, Wildlife and Parks. Although we were not be able to acquire an interest in all properties targeted this fiscal year due to limited time, BPA staff constraints, and negotiation constraints, we expended approximately $4.2M providing BPA with 4.2 km of credit. The Siderius and Gardner parcels were protected with conservation easements. The Siderius conservation easement is held by the Flathead Land Trust and the Gardner conservation easement is held by the Tribes. Fee title was acquired for three parcels with the Tribes holding title to the Cole and Firestone parcels and MFWP holding title to the parcels acquired from Plum Creek Timber Company. All stream kilometers credited to BPA offset construction and inundation impacts (not operations related impacts) associated with Hungry Horse Dam as defined in the 1991 Hungry Horse Loss Assessment.« less

Reengagement in PTSD psychotherapy: A case-control study.

PubMed

Buchholz, Katherine R; Bohnert, Kipling M; Pfeiffer, Paul N; Valenstein, Marcia; Ganoczy, Dara; Anderson, RaeAnn E; Sripada, Rebecca K

2017-09-01

This study sought to identify patient characteristics and care processes related to reengagement in VA psychotherapy. Using national VA data, a retrospective cohort was constructed (N=24,492) of veterans who received a new PTSD diagnosis in FY08/FY09 and attended only one to five PTSD psychotherapy sessions. A nested case-control study was conducted comparing veterans who reengaged in psychotherapy (n=9649) in a 1:5 ratio with those who did not reengage by the end of FY12. Conditional logistic regression models were run to examine differences in sociodemographic, mental health, and service utilization factors between cases and controls. Among veterans in the study cohort, 39.4% reengaged in psychotherapy. In adjusted analyses, all measured types of health system encounters (primary care [OR=1.61], primary care mental health [OR=1.61], non-PTSD psychotherapy [OR=1.76], other non-PTSD mental health care [OR=1.43], other non-psychotherapy PTSD care [OR=3.31], emergency room [OR=1.14], and psychiatric hospitalization [OR=1.56]) were related to greater odds of reengagement in PTSD psychotherapy. Veterans' receipt of a broad range of care services may play an important role in reengagement in PCT psychotherapy, suggesting providers across care settings should be knowledgeable in how to support a Veteran's return to psychotherapy for PTSD. Published by Elsevier Inc.

FY17 Status Report: Research on Stress Corrosion Cracking of SNF Interim Storage Canisters.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schindelholz, Eric John; Bryan, Charles R.; Alexander, Christopher L.

This progress report describes work done in FY17 at Sandia National Laboratories (SNL) to assess the localized corrosion performance of container/cask materials used in the interim storage of spent nuclear fuel (SNF). Of particular concern is stress corrosion cracking (SCC), by which a through-wall crack could potentially form in a canister outer wall over time intervals that are shorter than possible dry storage times. Work in FY17 refined our understanding of the chemical and physical environment on canister surfaces, and evaluated the relationship between chemical and physical environment and the form and extent of corrosion that occurs. The SNL corrosionmore » work focused predominantly on pitting corrosion, a necessary precursor for SCC, and process of pit-to-crack transition; it has been carried out in collaboration with university partners. SNL is collaborating with several university partners to investigate SCC crack growth experimentally, providing guidance for design and interpretation of experiments.« less

Carbon chemistry of circumstellar envelopes

NASA Technical Reports Server (NTRS)

Bieging, John H.

1990-01-01

The chemical composition of envelopes surrounding cool evolved stars, as determined from microwave spectroscopic observations, is reviewed. Emphasis is placed on recent observations with the new large mm-wavelength telescopes and interferometer arrays, and on new theoretical work, especially concerning ion-molecule chemistry of carbon-bearing in these envelopes. Thermal (as opposed to maser) emission lines are discussed. Much progress has been made in the past few years in the theoretical understanding of these objects. It is already clear, however, that observations with the new generation of mm-telescopes will require substantial improvements in the theoretical models to achieve a thorough understanding of the data now becoming available.

2009 Annual Progress Report: DOE Hydrogen Program, November 2009 (Book)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2009-11-01

This report summarizes the hydrogen and fuel cell R&D activities and accomplishments of the DOE Hydrogen Program for FY2009. It covers the program areas of hydrogen production and delivery; fuel cells; manufacturing; technology validation; safety, codes and standards; education; and systems analysis.

A baculovirus polyhedron envelope protein: immunogold localization in infected cells and mature polyhedra.

PubMed

Russell, R L; Rohrmann, G F

1990-01-01

A polyclonal antiserum against a trpE fusion protein containing the complete open reading frame of the polyhedron envelope (PE) protein from the nuclear polyhedrosis virus of Orgyia pseudotsugata (OpMNPV) was used for immunogold staining and electron microscopic examination of polyhedra, isolated polyhedron envelopes, and infected insect cells at selected times postinfection. The antiserum specifically stained the peripheral envelope of mature polyhedra and also stained the envelope structure which remained after polyhedra were dissolved in dilute alkaline solutions. In OpMNPV-infected Lymantria dispar cells, the PE protein was detected by 48 hr postinfection (hr p.i.) but specific localization and staining of developing polyhedra were not evident. However, by 72 hr p.i. substantial and preferential staining of the periphery of developing polyhedra was evident even though a distinct polyhedron envelope was not yet observed. In addition, the periphery of fibrillar structures was stained by the PE antiserum. By 96 hr p.i., mature envelopes surrounded polyhedra and these polyhedron envelopes were stained with the PE antibody. The progression of PE protein staining during polyhedron morphogenesis indicates that the PE protein accumulates and becomes associated with developing polyhedra in the nucleus between 48 and 72 hr p.i. Very late in infection the mature polyhedron envelope forms on the polyhedron surface. The apparent affinity of the PE protein for the surface of maturing polyhedra suggests that it may be a major component of the polyhedron envelope or may form the matrix for the deposition of other components which contribute to the mature envelope. Immunogold staining and protease digestion experiments indicate that protein is an essential component of the polyhedron envelope.

FY 2005 Annual Progress Report for the DOE Hydrogen Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

In cooperation with industry, academia, national laboratories, and other government agencies, the Department of Energy's Hydrogen Program is advancing the state of hydrogen and fuel cell technologies in support of the President's Hydrogen Fuel Initiative. The initiative seeks to develop hydrogen, fuel cell, and infrastructure technologies needed to make it practical and cost-effective for Americans to choose to use fuel cell vehicles by 2020. Significant progress was made in fiscal year 2005 toward that goal.

Network Speech Systems Technology Program

NASA Astrophysics Data System (ADS)

Weinstein, C. J.

1980-09-01

This report documents work performed during FY 1980 on the DCA-sponsored Network Speech Systems Technology Program. The areas of work reported are: (1) communication systems studies in Demand-Assignment Multiple Access (DAMA), voice/data integration, and adaptive routing, in support of the evolving Defense Communications System (DCS) and Defense Switched Network (DSN); (2) a satellite/terrestrial integration design study including the functional design of voice and data interfaces to interconnect terrestrial and satellite network subsystems; and (3) voice-conferencing efforts dealing with support of the Secure Voice and Graphics Conferencing (SVGC) Test and Evaluation Program. Progress in definition and planning of experiments for the Experimental Integrated Switched Network (EISN) is detailed separately in an FY 80 Experiment Plan Supplement.

US (United States) Army Aeromedical Research Laboratory Annual Progress Report, FY 1982.

DTIC Science & Technology

1982-10-01

A’D-li29 854 US(U! TESES ARMY AEROMEDICAL RESEARSH LABORAT ORY 1/2 INNUARGRESS REPORT FY 1982(U RMY NERONEDICRI U Lh RESEARCH4 LAB FORT RUCKER AL...groiath in atl iareas Of suIpport for the 1laborataory , mo Ii of hiich was d iInec tIYnt ie to the mave to the new facilities. Biomedical Engineering ...i L I II 1- C1 : l It0j. I I Office of the Building Engineer ’IA II ’ , the J i rector, I tLS f)iv isi o , SLICC SS CL11 I Il V lez t IA tC Acd CLI

Advanced Fuels Campaign 2016 Accomplishments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richardson, Kate M.

AFC management and integration activities in FY-16 included continued support for international collaborations, primarily with France, Japan, the European Union, Republic of Korea, and China, as well as various working group and expert group activities in the Organization for Economic Cooperation and Development Nuclear Energy Agency (OECD-NEA) and the International Atomic Energy Agency (IAEA). Three industry-led Funding Opportunity Announcements (FOAs) and two university-led Integrated Research Projects (IRPs) funded in 2013, made significant progress in fuels and materials development. All are closely integrated with AFC and accident-tolerant fuels (ATF) research. Accomplishments made during FY-16 are highlighted in this report, which focusesmore » on completed work and results.« less

Laboratory-directed research and development: FY 1996 progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vigil, J.; Prono, J.

1997-05-01

This report summarizes the FY 1996 goals and accomplishments of Laboratory-Directed Research and Development (LDRD) projects. It gives an overview of the LDRD program, summarizes work done on individual research projects, and provides an index to the projects` principal investigators. Projects are grouped by their LDRD component: Individual Projects, Competency Development, and Program Development. Within each component, they are further divided into nine technical disciplines: (1) materials science, (2) engineering and base technologies, (3) plasmas, fluids, and particle beams, (4) chemistry, (5) mathematics and computational sciences, (6) atomic and molecular physics, (7) geoscience, space science, and astrophysics, (8) nuclear andmore » particle physics, and (9) biosciences.« less

An Elegant Low-cost Materials Solution for Achieving Low Insertion Loss, Affordable Tunable Filters for Next Generation Mobile Communications Platforms

DTIC Science & Technology

2009-04-01

material design, complex oxide , UV photon irradiation 16. SECURITY CLASSIFICATION OF: 19a. NAME OF RESPONSIBLE PERSON Melanie W. Cole a. REPORT...1 1. Objective The objective of this effort was to develop a novel materials technology solution to achieve high-Q perovskite oxide thin...year 2008 (FY08) Director’s Research Initiative (DRI), we developed a post- growth ultraviolet (UV)- oxidation process science protocol to improve the

FY2007 Laboratory Directed Research and Development Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Craig, W W; Sketchley, J A; Kotta, P R

The Laboratory Directed Research and Development (LDRD) annual report for fiscal year 2007 (FY07) provides a summary of LDRD-funded projects for the fiscal year and consists of two parts: An introduction to the LDRD Program, the LDRD portfolio-management process, program statistics for the year, and highlights of accomplishments for the year. A summary of each project, submitted by the principal investigator. Project summaries include the scope, motivation, goals, relevance to Department of Energy (DOE)/National Nuclear Security Administration (NNSA) and Lawrence Livermore National Laboratory (LLNL) mission areas, the technical progress achieved in FY07, and a list of publications that resulted frommore » the research in FY07. Summaries are organized in sections by research category (in alphabetical order). Within each research category, the projects are listed in order of their LDRD project category: Strategic Initiative (SI), Exploratory Research (ER), Laboratory-Wide Competition (LW), and Feasibility Study (FS). Within each project category, the individual project summaries appear in order of their project tracking code, a unique identifier that consists of three elements. The first is the fiscal year the project began, the second represents the project category, and the third identifies the serial number of the proposal for that fiscal year.« less

FY2016 Advanced Combustion Engine Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Advanced Combustion Engine research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research focuses on addressing critical barriers to commercializing higher efficiency, very low emissions advanced internal combustion engines for passenger and commercial vehicles.

77 FR 42359 - FTA Supplemental Fiscal Year 2012 Apportionments, Allocations, and Program Information

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-18

... FEDERAL TRANSIT ADMINISTRATION FTA Supplemental Fiscal Year 2012 Apportionments, Allocations, and... partial apportionment notices. This notice announces the full fiscal year (FY) 2012 contract authority... Transportation Extension Act of 2012, Part II, Found in Division G of Moving Ahead for Progress in the 21st...

FY2014 Advanced Combustion Engine Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2015-03-01

The Advanced Combustion Engine research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research focuses on addressing critical barriers to commercializing higher efficiency, very low emissions advanced internal combustion engines for passenger and commercial vehicles.

FY2017 Advanced Combustion Systems and Fuels Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Advanced Combustion Systems and Fuels Program supports VTO’s goal and focuses early-stage research and development (R&D) to improve understanding of the combustion processes, fuel properties, and emission control technologies while generating knowledge and insight necessary for industry to develop the next generation of engines.

DEVELOPING A LANDSCAPE APPROACH TO EVALUATION OF WETLAND CONDITION IN THE SOUTHERN ROCKY MOUNTAINS: PHASE II.

EPA Science Inventory

This proposal details a project whose goal is to develop a rapid assessment tool for determining the success of compensatory wetland mitigation within a hydrogeomorphic framework. Phase I of this program, currently in progress and funded through FY 2000 RARE funds, is developing...

FY2016 Vehicle Systems Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

Vehicle Systems is concerned with advancing light-, medium-, and heavy-duty (HD) vehicle systems to support DOE’s goals of developing technologies for the U.S. transportation sector that enhance national energy security,increase U.S. competitiveness in the global economy, and support improvement of U.S. transportation and energy infrastructure.

FY2015 Advanced Combustion Engine Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Gurpreet; Gravel, Roland M.; Howden, Kenneth C.

The Advanced Combustion Engine research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research focuses on addressing critical barriers to commercializing higher efficiency, very low emissions advanced internal combustion engines for passenger and commercial vehicles.

LDRD final report : leveraging multi-way linkages on heterogeneous data.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dunlavy, Daniel M.; Kolda, Tamara Gibson

2010-09-01

This report is a summary of the accomplishments of the 'Leveraging Multi-way Linkages on Heterogeneous Data' which ran from FY08 through FY10. The goal was to investigate scalable and robust methods for multi-way data analysis. We developed a new optimization-based method called CPOPT for fitting a particular type of tensor factorization to data; CPOPT was compared against existing methods and found to be more accurate than any faster method and faster than any equally accurate method. We extended this method to computing tensor factorizations for problems with incomplete data; our results show that you can recover scientifically meaningfully factorizations withmore » large amounts of missing data (50% or more). The project has involved 5 members of the technical staff, 2 postdocs, and 1 summer intern. It has resulted in a total of 13 publications, 2 software releases, and over 30 presentations. Several follow-on projects have already begun, with more potential projects in development.« less

Spacecraft Internal Acoustic Environment Modeling

NASA Technical Reports Server (NTRS)

Chu, Shao-Sheng R.; Allen Christopher S.

2010-01-01

Acoustic modeling can be used to identify key noise sources, determine/analyze sub-allocated requirements, keep track of the accumulation of minor noise sources, and to predict vehicle noise levels at various stages in vehicle development, first with estimates of noise sources, later with experimental data. This paper describes the implementation of acoustic modeling for design purposes by incrementally increasing model fidelity and validating the accuracy of the model while predicting the noise of sources under various conditions. During FY 07, a simple-geometry Statistical Energy Analysis (SEA) model was developed and validated using a physical mockup and acoustic measurements. A process for modeling the effects of absorptive wall treatments and the resulting reverberation environment were developed. During FY 08, a model with more complex and representative geometry of the Orion Crew Module (CM) interior was built, and noise predictions based on input noise sources were made. A corresponding physical mockup was also built. Measurements were made inside this mockup, and comparisons were made with the model and showed excellent agreement. During FY 09, the fidelity of the mockup and corresponding model were increased incrementally by including a simple ventilation system. The airborne noise contribution of the fans was measured using a sound intensity technique, since the sound power levels were not known beforehand. This is opposed to earlier studies where Reference Sound Sources (RSS) with known sound power level were used. Comparisons of the modeling result with the measurements in the mockup showed excellent results. During FY 10, the fidelity of the mockup and the model were further increased by including an ECLSS (Environmental Control and Life Support System) wall, associated closeout panels, and the gap between ECLSS wall and mockup wall. The effect of sealing the gap and adding sound absorptive treatment to ECLSS wall were also modeled and validated.

2014 Fermilab Laboratory Directoed Research & Development Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

W. Wester

After initiation by the Fermilab Laboratory Director, a team from the senior Laboratory leadership and a Laboratory Directed Research and Development (LDRD) Advisory Committee developed an implementation plan for LDRD at Fermilab for the first time. This implementation was captured in the approved Fermilab 2014 LDRD Program Plan and followed directions and guidance from the Department of Energy (DOE) order, DOE O 413.2B, a “Roles, Responsibilities, and Guidelines, …” document, and examples of best practices at other DOE Office of Science Laboratories. At Fermilab, a FY14 midyear Call for Proposals was issued. A LDRD Selection Committee evaluated those proposals thatmore » were received and provided a recommendation to the Laboratory Director who approved seven LDRD projects. This Annual Report focuses on the status of those seven projects and provides an overview of the current status of LDRD at Fermilab. The seven FY14 LDRD approved projects had a date of initiation late in FY14 such that this report reflects approximately six months of effort approximately through January 2015. The progress of these seven projects, the subsequent award of six additional new projects beginning in FY15, and preparations for the issuance of the FY16 Call for Proposals indicates that LDRD is now integrated into the overall annual program at Fermilab. All indications are that LDRD is improving the scientific and technical vitality of the Laboratory and providing new, novel, or cutting edge projects carried out at the forefront of science and technology and aligned with the mission and strategic visions of Fermilab and the Department of Energy.« less

Advanced Fluid Reduced Order Models for Compressible Flow.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tezaur, Irina Kalashnikova; Fike, Jeffrey A.; Carlberg, Kevin Thomas

This report summarizes fiscal year (FY) 2017 progress towards developing and implementing within the SPARC in-house finite volume flow solver advanced fluid reduced order models (ROMs) for compressible captive-carriage flow problems of interest to Sandia National Laboratories for the design and qualification of nuclear weapons components. The proposed projection-based model order reduction (MOR) approach, known as the Proper Orthogonal Decomposition (POD)/Least- Squares Petrov-Galerkin (LSPG) method, can substantially reduce the CPU-time requirement for these simulations, thereby enabling advanced analyses such as uncertainty quantification and de- sign optimization. Following a description of the project objectives and FY17 targets, we overview briefly themore » POD/LSPG approach to model reduction implemented within SPARC . We then study the viability of these ROMs for long-time predictive simulations in the context of a two-dimensional viscous laminar cavity problem, and describe some FY17 enhancements to the proposed model reduction methodology that led to ROMs with improved predictive capabilities. Also described in this report are some FY17 efforts pursued in parallel to the primary objective of determining whether the ROMs in SPARC are viable for the targeted application. These include the implemen- tation and verification of some higher-order finite volume discretization methods within SPARC (towards using the code to study the viability of ROMs on three-dimensional cavity problems) and a novel structure-preserving constrained POD/LSPG formulation that can improve the accuracy of projection-based reduced order models. We conclude the report by summarizing the key takeaways from our FY17 findings, and providing some perspectives for future work.« less

The Analysis of Inter-calibration Between FY-3C/TOU, NPP/OMPS and Metop/GOME-2

NASA Astrophysics Data System (ADS)

Wang, H.; Hu, X.

2017-12-01

Total ozone unit (TOU), one of the main payloads on FY-3C satellite, is the instrument for daily global coverage of total ozone monitoring in China. It has been in-orbit for about four years since October 2013. However, its solar irradiance is not correct because all of three diffuser boards cannot work normally. Therefore, in-orbit inter-calibration of radiance and reflectance are studied for TOU measurement. A method is introduced for inter-calibration between FY-3C/TOU and NPP/OMPS, Metop-B/GOME-2. It includes orbit forecast, temporal concurrent, spatial collocation, geometrical alignement, uniform filtration, and spectral consistent. Then, it is used for TOU data of 3 years from 2014 to 2016. The slopes of radiance inter-calibration equations of 360 nm between TOU (y-axis) and NPP/OMPS (x-axis) decrease gradually from 1 to 0.96. The slopes of radiance inter-calibration equations of 360 nm between TOU (y-axis) and Metop-B/GOME2 (x-axis) increased gradually from 1.12 to 1.72, while the slopes between TOU and Metop-A/GOME2 varied within 2.1-2.3. Most relation coefficients (R2) of them are >0.8. The inter-calibration results, combining with the solar irradiance of OMPS/GOME-2, will be used for the attenuation analysis of TOU measurements.

FY-15 Progress Report on Cleanup of irradiated SHINE Target Solutions Containing 140g-U/L Uranyl Sulfate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bennett, Megan E.; Bowers, Delbert L.; Vandegrift, George F.

2015-09-01

During FY 2012 and 2013, a process was developed to convert the SHINE Target Solution (STS) of irradiated uranyl sulfate (140 g U/L) to uranyl nitrate. This process is necessary so that the uranium solution can be processed by the UREX (Uranium Extraction) separation process, which will remove impurities from the uranium so that it can be recycled. The uranyl sulfate solution must contain <0.02 M SO 4 2- so that the uranium will be extractable into the UREXsolvent. In addition, it is desired that the barium content be below 0.0007 M, as this is the limit in the Resourcemore » Conservation and Recovery Act (RCRA).« less

Milestone Completion Report WBS 1.3.5.05 ECP/VTK-m FY17Q3 [MS-17/02] Faceted Surface Normals STDA05-3.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moreland, Kenneth D.

2017-07-01

The FY17Q3 milestone of the ECP/VTK-m project includes the completion of a VTK-m filter that computes normal vectors for surfaces. Normal vectors are those that point perpendicular to the surface and are an important direction when rendering the surface. The implementation includes the parallel algorithm itself, a filter module to simplify integrating it into other software, and documentation in the VTK-m Users’ Guide. With the completion of this milestone, we are able to necessary information to rendering systems to provide appropriate shading of surfaces. This milestone also feeds into subsequent milestones that progressively improve the approximation of surface direction.

Oak Ridge Reservation Federal Facility Agreement. Quarterly report for the Environmental Restoration Program. Volume 4, July 1995--September 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This quarterly progress report satisfies requirements for the Environmental Restoration (ER) Program that are specified in the Oak Ridge Reservation Federal Facility Agreement (FFA) established between the U.S. Department of Energy (DOE), the U.S. Environmental Protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC). The reporting period covered herein is July through September 1995 (fourth quarter of FY 1995). Sections 1.1 and 1.2 provide respectively the milestones scheduled for completion during the reporting period and a list of documents that have been proposed for transmittal during the following quarter but have not been approved as FY 1995more » commitments.« less

Southern Rural Development Center Annual Progress Report, FY 1981.

ERIC Educational Resources Information Center

Southern Rural Development Center, Mississippi State, MS.

Since 1974 the Southern Rural Development Center (SRDC) has provided support staff for capacity building and innovative programming for the experiment stations and extension services of 28 land-grant universities in 13 southern states and Puerto Rico. The Center exists to provide the best possible information and assistance to extension and…

U.S. Army Aeromedical Research Laboratory Annual Progress Report FY 1986

DTIC Science & Technology

1986-10-01

19 Contracts ................................................. 19 Small Business Innovation...universities and businesses which parallels the research requirements of the laboratories under the USAMRDC command. Because of the scientific manpower...Software is being written to allow double entry verification of data. 2) Small business innovation research Each year, in compliance with the Small

FY2013 Lightweight Materials R&D Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2014-02-01

As part of the U.S. Department of Energy’s (DOE’s) Vehicle Technologies Program (VTO), the Lightweight Materials (LM) activity focuses on the development and validation of advanced materials and manufacturing technologies to significantly reduce light and heavy duty vehicle weight without compromising other attributes such as safety, performance, recyclability, and cost.

BNL National Synchrotron Light Source activity report 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

During FY 1997 Brookhaven National Laboratory celebrated its 50th Anniversary and 50 years of outstanding achievement under the management of Associated Universities, Inc. This progress report is divided into the following sections: (1) introduction; (2) science highlights; (3) meetings and workshops; (4) operations; (5) projects; (6) organization; and (7) abstracts and publications.

Validation of Short-Term Noise Assessment Procedures: FY16 Summary of Procedures, Progress, and Preliminary Results

DTIC Science & Technology

Validation project. This report describes the procedure used to generate the noise models output dataset , and then it compares that dataset to the...benchmark, the Engineer Research and Development Centers Long-Range Sound Propagation dataset . It was found that the models consistently underpredict the

Progress Towards Providing Heat-Shield for Extreme Entry Environment Technology (HEEET) for Venus and Other New Froniters Missions

NASA Astrophysics Data System (ADS)

Venkatapathy, E.; Ellerby, D.; Gage, P.

2017-11-01

HEEET, in development since 2014 with the goal of enabling missions to Venus, Saturn and other high-speed sample return missions, is incentivized by SMD-PSD and will be delivered at TRL 6 by FY'18. This presentation will cover the current status.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boparai, A. S.; Bowers, D. L.; Graczyk, D. G.

This report summarizes the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for Fiscal Year (FY) 1998 (October 1997 through September 1998). This annual progress report, which is the fifteenth in this series for the ACL, describes effort on continuing projects, work on new projects, and contributions of the ACL staff to various programs at ANL.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, D. W.; Boparai, A. S.; Bowers, D. L.

This report summarizes the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for Fiscal Year (FY) 1999 (October 1998 through September 1999). This annual progress report, which is the sixteenth in this series for the ACL, describes effort on continuing projects, work on new projects, and contributions of the ACL staff to various programs at ANL.

76 FR 12996 - Advisory Committee for Biological Sciences; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-09

.... Purpose of Meeting: The Advisory Committee for BIO provides advice, recommendations, and oversight... that make up BIO. Agenda: Items on the agenda include the NSF and BIO FY 2012 budget request, the 2010 America Competes Act, and a progress report on BIO's ongoing experiments in innovation. In addition, the...

U.S. Army Medical Bioengineering Research and Development Laboratory Annual Progress Report FY 1985. Volume 1

DTIC Science & Technology

1985-10-01

heterotrophic carbon dioxide fixa- tion. An assay for T2 toxin using the yeast Cryptococcus luteolus was evaluated as a rapid screening device for toxic...Bioassay for Mycotoxins Using Cryptococcus luteolus with Tetrazolium Salts." Poster session at the American Soc. for Microbiol. Annual Meeting, March

Microgravity Science and Applications. Program Tasks and Bibliography for FY 1993

NASA Technical Reports Server (NTRS)

1994-01-01

An annual report published by the Microgravity Science and Applications Division (MSAD) of NASA is presented. It represents a compilation of the Division's currently-funded ground, flight and Advanced Technology Development tasks. An overview and progress report for these tasks, including progress reports by principal investigators selected from the academic, industry and government communities, are provided. The document includes a listing of new bibliographic data provided by the principal investigators to reflect the dissemination of research data during FY 1993 via publications and presentations. The document also includes division research metrics and an index of the funded investigators. The document contains three sections and three appendices: Section 1 includes an introduction and metrics data, Section 2 is a compilation of the task reports in an order representative of its ground, flight or ATD status and the science discipline it represents, and Section 3 is the bibliography. The three appendices, in the order of presentation, are: Appendix A - a microgravity science acronym list, Appendix B - a list of guest investigators associated with a biotechnology task, and Appendix C - an index of the currently funded principal investigators.

Enhancement of antitumor activity of gammaretrovirus carrying IL-12 gene through genetic modification of envelope targeting HER2 receptor: a promising strategy for bladder cancer therapy.

PubMed

Tsai, Y-S; Shiau, A-L; Chen, Y-F; Tsai, H-T; Tzai, T-S; Wu, C-L

2010-01-01

The objective of this study was to develop an HER2-targeted, envelope-modified Moloney murine leukemia virus (MoMLV)-based gammaretroviral vector carrying interleukin (IL)-12 gene for bladder cancer therapy. It displayed a chimeric envelope protein containing a single-chain variable fragment (scFv) antibody to the HER2 receptor and carried the mouse IL-12 gene. The fragment of anti-erbB2scFv was constructed into the proline-rich region of the viral envelope of the packaging vector lacking a transmembrane subunit of the carboxyl terminal region of surface subunit. As compared with envelope-unmodified gammaretroviruses, envelope-modified ones had extended viral tropism to human HER2-expressing bladder cancer cell lines, induced apoptosis, and affected cell cycle progression despite lower viral titers. Moreover, animal studies showed that envelope-modified gammaretroviruses carrying IL-12 gene exerted higher antitumor activity in terms of retarding tumor growth and prolonging the survival of tumor-bearing mice than unmodified ones, which were associated with enhanced tumor cell apoptosis as well as increased intratumoral levels of IL-12, interferon-gamma, IL-1beta, and tumor necrosis factor-alpha proteins. Therefore, the antitumor activity of gammaretroviruses carrying the IL-12 gene was enhanced through genetic modification of the envelope targeting HER2 receptor, which may be a promising strategy for bladder cancer therapy.

HIV envelope-mediated, CCR5/α4β7-dependent killing of CD4-negative γδ T cells which are lost during progression to AIDS.

PubMed

Li, Haishan; Pauza, C David

2011-11-24

HIV infects and replicates in CD4+ T cells but effects on host immunity and disease also involve depletion, hyper-activation, and modification of CD4-negative cell populations. In particular, the depletion of CD4-negative γδ T cells is common to all HIV+ individuals. We found that soluble or cell-associated envelope glycoproteins from CCR5-tropic strains of HIV could bind, activates the p38-caspase pathway, and induce the death of γδ cells. Envelope binding requires integrin α4β7 and chemokine receptor CCR5 which are at high levels and form a complex on the γδ T cell membrane. This receptor complex facilitated V3 loop binding to CCR5 in the absence of CD4-induced conformational changes. Cell death was increased by antigen stimulation after exposure to envelope glycoprotein. Direct signaling by envelope glycoprotein killed CD4-negative γδ T cells and reproduced a defect observed in all patients with HIV disease.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rutqvist, Jonny; Blanco Martin, Laura; Mukhopadhyay, Sumit

In this report, we present FY2014 progress by Lawrence Berkeley National Laboratory (LBNL) related to modeling of coupled thermal-hydrological-mechanical-chemical (THMC) processes in salt and their effect on brine migration at high temperatures. LBNL’s work on the modeling of coupled THMC processes in salt was initiated in FY2012, focusing on exploring and demonstrating the capabilities of an existing LBNL modeling tool (TOUGH-FLAC) for simulating temperature-driven coupled flow and geomechanical processes in salt. This work includes development related to, and implementation of, essential capabilities, as well as testing the model against relevant information and published experimental data related to the fate andmore » transport of water. we provide more details on the FY2014 work, first presenting updated tools and improvements made to the TOUGH-FLAC simulator, and the use of this updated tool in a new model simulation of long-term THM behavior within a generic repository in a salt formation. This is followed by the description of current benchmarking and validations efforts, including the TSDE experiment. We then present the current status in the development of constitutive relationships and the dual-continuum model for brine migration. We conclude with an outlook for FY2015, which will be much focused on model validation against field experiments and on the use of the model for the design studies related to a proposed heater experiment.« less

Integrated Disposal Facility FY 2012 Glass Testing Summary Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pierce, Eric M.; Kerisit, Sebastien N.; Krogstad, Eirik J.

2013-03-29

PNNL is conducting work to provide the technical basis for estimating radionuclide release from the engineered portion of the disposal facility for Hanford immobilized low-activity waste (ILAW). Before the ILAW can be disposed, DOE must conduct a performance assessment (PA) for the Integrated Disposal Facility (IDF) that describes the long-term impacts of the disposal facility on public health and environmental resources. As part of the ILAW glass testing program, PNNL is implementing a strategy, consisting of experimentation and modeling, to provide the technical basis for estimating radionuclide release from the glass waste form in support of future IDF PAs. Keymore » activities in FY12 include upgrading the STOMP/eSTOMP codes to do near-field modeling, geochemical modeling of PCT tests to determine the reaction network to be used in the STOMP codes, conducting PUF tests on selected glasses to simulate and accelerate glass weathering, developing a Monte Carlo simulation tool to predict the characteristics of the weathered glass reaction layer as a function of glass composition, and characterizing glasses and soil samples exhumed from an 8-year lysimeter test. The purpose of this report is to summarize the progress made in fiscal year (FY) 2012 and the first quarter of FY 2013 toward implementing the strategy with the goal of developing an understanding of the long-term corrosion behavior of LAW glasses.« less

Progress toward establishing a national assessment of water availability and use

USGS Publications Warehouse

Alley, William M.; Evenson, Eric J.; Barber, Nancy L.; Bruce, Breton W.; Dennehy, Kevin F.; Freeman, Mary C.; Freeman, Ward O.; Fischer, Jeffrey M.; Hughes, William B.; Kennen, Jonathan G.; Kiang, Julie E.; Maloney, Kelly O.; Musgrove, MaryLynn; Ralston, Barbara E.; Tessler, Steven; Verdin, James P.

2013-01-01

The Omnibus Public Land Management Act of 2009 (Public Law 111-11) was passed into law on March 30, 2009. Subtitle F, also known as the SECURE Water Act, calls for the establishment of a "national water availability and use assessment program" within the U.S. Geological Survey (USGS). A major driver for this recommendation was that national water availability and use have not been comprehensively assessed since 1978. This report fulfills a requirement to report to Congress on progress in implementing the national water availability and use assessment program, also referred to as the National Water Census. The SECURE Water Act authorized \\$20 million for each of fiscal years (FY) 2009 through 2023 for assessment of national water availability and use. The first appropriation for this effort was \\$4 million in FY 2011, followed by an appropriation of \\$6 million in FY 2012. The National Water Census synthesizes and reports information at the regional and national scales, with an emphasis on compiling and reporting the information in a way that is useful to states and others responsible for water management and natural-resource issues. The USGS works with Federal and non-Federal agencies, universities, and other organizations to ensure that the information can be aggregated with other types of water-availability and socioeconomic information, such as data on food and energy production. To maximize the utility of the information, the USGS coordinates the design and development of the effort through the Federal Advisory Committee on Water Information. A National Water Census is a complex undertaking, particularly because there are major gaps in the information needed to conduct such an assessment. To maximize progress, the USGS engaged stakeholders in a discussion of priorities and leveraged existing studies and program activities to enhance efforts toward the development of a National Water Census.

Columbia River Basin Fish and Wildlife Program Annual Implementation Work Plan for Fiscal Year 1991.

DOE Office of Scientific and Technical Information (OSTI.GOV)

United States. Bonneville Power Administration; Northwest Power Planning Council; Columbia Basin Fish and Wildlife Authority

1990-09-01

The Columbia River Basin Fish and Wildlife Program (Program) was developed by the Northwest Power Planning Council (Council) in accordance with Public Law 96-501, the Pacific Northwest Electric Power Planning and Conservation Act (Act). The purpose of the Program is to guide the Bonneville Power Administration (BPA) and other Federal agencies in carrying out their responsibilities to protect, mitigate, and enhance fish and wildlife of the Columbia River Basin. The Act explicitly gives BPA the authority and responsibility to use the BPA fund for these ends, to the extent that fish and wildlife are affected by the development and operationmore » of hydroelectric generation in the Columbia River Basin. The Columbia River Basin Fish and Wildlife Program Annual Implementation Work Plan (AIWP) presents BPA's draft plans for implementing the Program during Fiscal Year (FY) 1991. The AIWP reflects the primary goals of the Council's Action Plan (Section 1400 of the Program): to provide a solid, timely, and focused basis for budgeting and planning. In addition, the AIWP provides a means to judge the progress and the success of Program implementation. The AIWP is based on the outline developed by the Policy Review Group (PRG) during Step 1 of the annual cycle of the Implementation Planning Process (IPP), which is described in Section III. This AIWP has been organized and written to meet the specific needs of Program Items 10.1-10.3. The AIWP includes schedules with key milestones for 1 and beyond, and addresses the Action Items assigned to BPA in Section 1400 of the 1987 Program and in subsequent amendments. All Program projects discussed in the AIWP are listed in Tables 1 and 2 according to their status as of September 1, 1990. Table 1 (pp. 3-14) lists completed, ongoing, and deferred projects. Table 2 (pp. 15-17) lists FY 1991 new-start projects. ''Ongoing'' status indicates that the project started in FY 1990 or before and that it is expected to continue through part or all of FY 1991. ''Deferred'' means that BPA implementation has been postponed to FY 1992 or later. ''Completed'' indicates completion during FY 1990. ''New'' denotes projects planned for BPA implementation in FY 1991. However, several of these new projects were still under review by the Policy Review Group as the FY 1991 AIWP went to press. The new projects still under review have been noted in Table 2 and in the text of the AIWP. A number of projects are expected to begin in late FY 1990 and have been listed in Table 1 of the Draft AIWP as ''Projected FY '90 Starts,'' based on their projected start dates. Several other projects are expected to end in late FY 1990. These projects have been listed in Table 1 as ''Projected FY '90 Completions,'' based on their projected completion dates. Section VIII describes BPA's non-Program, internal support projects. These projects were not subject to review by the PRG and have been included in the AIWP to help the PRG and the public to better understand what BPA is doing.« less

Preserving Envelope Efficiency in Performance Based Code Compliance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thornton, Brian A.; Sullivan, Greg P.; Rosenberg, Michael I.

2015-06-20

The City of Seattle 2012 Energy Code (Seattle 2014), one of the most progressive in the country, is under revision for its 2015 edition. Additionally, city personnel participate in the development of the next generation of the Washington State Energy Code and the International Energy Code. Seattle has pledged carbon neutrality by 2050 including buildings, transportation and other sectors. The United States Department of Energy (DOE), through Pacific Northwest National Laboratory (PNNL) provided technical assistance to Seattle in order to understand the implications of one potential direction for its code development, limiting trade-offs of long-lived building envelope components less stringentmore » than the prescriptive code envelope requirements by using better-than-code but shorter-lived lighting and heating, ventilation, and air-conditioning (HVAC) components through the total building performance modeled energy compliance path. Weaker building envelopes can permanently limit building energy performance even as lighting and HVAC components are upgraded over time, because retrofitting the envelope is less likely and more expensive. Weaker building envelopes may also increase the required size, cost and complexity of HVAC systems and may adversely affect occupant comfort. This report presents the results of this technical assistance. The use of modeled energy code compliance to trade-off envelope components with shorter-lived building components is not unique to Seattle and the lessons and possible solutions described in this report have implications for other jurisdictions and energy codes.« less

Applied Meteorology Unit (AMU) Quarterly Report Third Quarter FY-08

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Barrett, Joe; Watson, Leela; Dreher, Joseph

2008-01-01

This report summarizes the Applied Meteorology Unit (AMU) activities for the third quarter of Fiscal Year 2008 (April - June 2008). Tasks reported on are: Peak Wind Tool for User Launch Commit Criteria (LCC), Anvil Forecast Tool in AWIPS Phase II, Completion of the Edward Air Force Base (EAFB) Statistical Guidance Wind Tool, Volume Averaged Height Integ rated Radar Reflectivity (VAHIRR), Impact of Local Sensors, Radar Scan Strategies for the PAFB WSR-74C Replacement, VAHIRR Cost Benefit Analysis, and WRF Wind Sensitivity Study at Edwards Air Force Base

AFOSR Chemistry Program Review FY-79 (24th).

DTIC Science & Technology

1980-03-01

made can be found in the "EOARD Quarterly Highlights." NEW PROJECTS An exciting new project in the field of multi-component glasses for optical...fibers was begun with Professor Renata Reisfeld at the Hebrew University of Jerusalem. Purpose of the study is to develop multi-component glass which will...have a high transparency in the 0.8 to 1.5 Um region of the spectrum. Combinations of oxides such as Si02, B20 3 , P 205 , GeO2 and TeO2 with alkali

Lawrence Livermore National Laboratory FY 2016 Laboratory Directed Research and Development Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Al-Ayat, R.; Gard, E.; Sketchley, J.

The LDRD annual report for FY2016 consists of two parts: The Overview. This section contains a broad description of the LDRD Program, highlights of recent accomplishments and awards, Program statistics, and the LDRD portfolio-management processes. Project Reports. Project reports are submitted by all principal investigators at the end of the fiscal year. The length and depth of the report depends on the project’s lifecycle. For projects that will be continuing the following year, the principal investigator submits a continuing project report, which is a brief update containing descriptions of the goals, scope, motivation, relevance (to DOE/NNSA and Livermore mission areas),more » and technical progress achieved in FY16, as well as a list of selected publications and presentations that resulted from the research. For projects that concluded in FY16, a more detailed final report is provided that is technical in nature and includes the background, objectives, scientific approach, accomplishments, and impacts on the Laboratory missions, as well as a list of publications and presentations that resulted from the research. Project reports are listed under their research topics and organized by year and type, such as exploratory research (ER), feasibility study (FS), laboratory-wide competition (LW), and strategic initiative (SI). Each project is assigned a unique tracking code, an identifier that consists of three elements. The first is the fiscal year in which the project began, the second represents the project type, and the third identifies the serial number of the project for that fiscal year. For example, 16-ERD-100 means the project is an exploratory research project that began in FY16. The three-digit number (100) represents the serial number for the project.« less

FY2004 SYSTEM ENGINEER PROGRAM MANAGER ANNUAL REPORT

DOE Office of Scientific and Technical Information (OSTI.GOV)

JACKSON, G.J.

2004-10-29

During FY 2004, reviews of the FH System Engineer (SE) Program were conducted by the Independent Assessment (IA) Group. The results of these reviews are summarized as a part of this document. Additional reviews were performed by FH Engineering personnel. SE Engineering reviews performed include Periodic Walkdowns (typically, quarterly) by the SEs, a review of System Notebooks by the System Engineer Program Manager (SEPM), annual status report by each SE, and an annual status report by each of the Project Chief Engineers (PCEs). FY 2004 marked the completion of the first round of Vital Safety System assessments. Each of themore » VSSs on the FH VSS list has been evaluated at least once by either the FH Independent Assessment organization or was included as a part of DOE Phase II assessment. Following the completion of the K-Basins Assessment in May 2004, a review of the VSS assessment process was completed. Criteria were developed by FH, and concurred with by RL, to determine the frequency and priority of future VSS assessments. Additional actions have been taken to increase the visibility and emphasis assigned to VSSs. Completion of several Documented Safety Analyses (DSA), in combination with efforts to remove source term materials from several facilities, enabled the number of systems on the FH VSS list to be reduced from 60 at the beginning of FY 2004 to 48 by the end of FY 2004. It is expected that there will be further changes to the FH VSS list based on additional DSA revisions and continued progress towards reduction of source terms across the Hanford Site. Other new VSSs may be added to the list to reflect the relocation of materials away from the River Corridor to interim storage locations on the Central Plateau.« less

Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor

PubMed Central

Burton, Liza J.; Dougan, Jodi; Jones, Jasmine; Smith, Bethany N.; Randle, Diandra; Henderson, Veronica

2016-01-01

ABSTRACT The epithelial mesenchymal transition (EMT) promotes tumor migration and invasion by downregulating epithelial markers such as E-cadherin and upregulating mesenchymal markers such as vimentin. Cathepsin L (Cat L) is a cysteine protease that can proteolytically activate CCAAT displacement protein/cut homeobox transcription factor (CUX1). We hypothesized that nuclear Cat L may promote EMT via CUX1 and that this could be antagonized with the Cat L-specific inhibitor Z-FY-CHO. Mesenchymal prostate (ARCaP-M and ARCaP-E overexpressing Snail) and breast (MDA-MB-468, MDA-MB-231, and MCF-7 overexpressing Snail) cancer cells expressed lower E-cadherin activity, higher Snail, vimentin, and Cat L activity, and a p110/p90 active CUX1 form, compared to epithelial prostate (ARCaP-E and ARCaP-Neo) and breast (MCF-7 and MCF-7 Neo) cancer cells. There was increased binding of CUX1 to Snail and the E-cadherin promoter in mesenchymal cells compared to epithelial prostate and breast cells. Treatment of mesenchymal cells with the Cat L inhibitor Z-FY-CHO led to nuclear-to-cytoplasmic relocalization of Cat L, decreased binding of CUX1 to Snail and the E-cadherin promoter, reversed EMT, and decreased cell migration/invasion. Overall, our novel data suggest that a positive feedback loop between Snail-nuclear Cat L-CUX1 drives EMT, which can be antagonized by Z-FY-CHO. Therefore, Z-FY-CHO may be an important therapeutic tool to antagonize EMT and cancer progression. PMID:27956696

Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor.

PubMed

Burton, Liza J; Dougan, Jodi; Jones, Jasmine; Smith, Bethany N; Randle, Diandra; Henderson, Veronica; Odero-Marah, Valerie A

2017-03-01

The epithelial mesenchymal transition (EMT) promotes tumor migration and invasion by downregulating epithelial markers such as E-cadherin and upregulating mesenchymal markers such as vimentin. Cathepsin L (Cat L) is a cysteine protease that can proteolytically activate CCAAT displacement protein/cut homeobox transcription factor (CUX1). We hypothesized that nuclear Cat L may promote EMT via CUX1 and that this could be antagonized with the Cat L-specific inhibitor Z-FY-CHO. Mesenchymal prostate (ARCaP-M and ARCaP-E overexpressing Snail) and breast (MDA-MB-468, MDA-MB-231, and MCF-7 overexpressing Snail) cancer cells expressed lower E-cadherin activity, higher Snail, vimentin, and Cat L activity, and a p110/p90 active CUX1 form, compared to epithelial prostate (ARCaP-E and ARCaP-Neo) and breast (MCF-7 and MCF-7 Neo) cancer cells. There was increased binding of CUX1 to Snail and the E-cadherin promoter in mesenchymal cells compared to epithelial prostate and breast cells. Treatment of mesenchymal cells with the Cat L inhibitor Z-FY-CHO led to nuclear-to-cytoplasmic relocalization of Cat L, decreased binding of CUX1 to Snail and the E-cadherin promoter, reversed EMT, and decreased cell migration/invasion. Overall, our novel data suggest that a positive feedback loop between Snail-nuclear Cat L-CUX1 drives EMT, which can be antagonized by Z-FY-CHO. Therefore, Z-FY-CHO may be an important therapeutic tool to antagonize EMT and cancer progression. Copyright © 2017 American Society for Microbiology.

Bootstrapping data envelopment analysis of efficiency and productivity of county public hospitals in Eastern, Central, and Western China after the public hospital reform.

PubMed

Wang, Man-Li; Fang, Hai-Qing; Tao, Hong-Bing; Cheng, Zhao-Hui; Lin, Xiao-Jun; Cai, Miao; Xu, Chang; Jiang, Shuai

2017-10-01

China implemented the public hospital reform in 2012. This study utilized bootstrapping data envelopment analysis (DEA) to evaluate the technical efficiency (TE) and productivity of county public hospitals in Eastern, Central, and Western China after the 2012 public hospital reform. Data from 127 county public hospitals (39, 45, and 43 in Eastern, Central, and Western China, respectively) were collected during 2012-2015. Changes of TE and productivity over time were estimated by bootstrapping DEA and bootstrapping Malmquist. The disparities in TE and productivity among public hospitals in the three regions of China were compared by Kruskal-Wallis H test and Mann-Whitney U test. The average bias-corrected TE values for the four-year period were 0.6442, 0.5785, 0.6099, and 0.6094 in Eastern, Central, and Western China, and the entire country respectively, with average non-technical efficiency, low pure technical efficiency (PTE), and high scale efficiency found. Productivity increased by 8.12%, 0.25%, 12.11%, and 11.58% in China and its three regions during 2012-2015, and such increase in productivity resulted from progressive technological changes by 16.42%, 6.32%, 21.08%, and 21.42%, respectively. The TE and PTE of the county hospitals significantly differed among the three regions of China. Eastern and Western China showed significantly higher TE and PTE than Central China. More than 60% of county public hospitals in China and its three areas operated at decreasing return scales. There was a considerable space for TE improvement in county hospitals in China and its three regions. During 2012-2015, the hospitals experienced progressive productivity; however, the PTE changed adversely. Moreover, Central China continuously achieved a significantly lower efficiency score than Eastern and Western China. Decision makers and administrators in China should identify the causes of the observed inefficiencies and take appropriate measures to increase the efficiency of county public hospitals in the three areas of China, especially in Central China.

Great Basin Native Plant Selection and Increase Project: FY2010 Progress Report

Treesearch

Nancy Shaw; Mike Pellant

2011-01-01

The Interagency Native Plant Materials Development Program outlined in the 2002 Report to Congress (USDI and USDA 2002), USDI Bureau of Land Management programs and policies, and the Great Basin Restoration Initiative encourage the use of native species for rangeland rehabilitation and restoration where feasible. This project was initiated to foster the development of...

Report on Beryllium Strength Experiments Conducted at the TA-55 40 mm Impact Test Facility, Fiscal Year 2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, William Wyatt; Hollowell, Benjamin Charles; Martinez, Todd P.

A series of experiments is currently in progress at eth 40 mm Impact Test Facility (ITF), located at TA-55, to understand the strength behavior of Beryllium metal at elevated temperature and pressure. In FY 2017, three experiments were conducted as a part of this project.

National Fire Plan Research and Development 2002 Business Summary

Treesearch

USDA Forest Service

2003-01-01

This report summarizes the progress made by Forest Service NFP R&D in FY2002, the second year of NFP funding. Fire research conducted by Forest Service R&D is working to provide the scientific foundation necessary to increase firefighting safety and effectiveness, enhance restoration of fire-scarred landscapes, reduce fire risk through improved management of...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, D.W.; Boparai, A.S.; Bowers, D.L.

The purpose of this report is to summarize the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for Fiscal Year (FY) 1997 (October 1996 through September 1997). This annual progress report is the fourteenth in this series for the ACL, and it describes continuing effort on projects, work on new projects, and contributions of the ACL staff to various programs at ANL.

FY2015 Vehicle Systems Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Vehicle Systems research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research focuses on addressing critical barriers to advancing light-, medium-, and heavy-duty vehicle systems to help maximize the number of electric miles driven and increase the energy efficiency of transportation vehicles.

U.S. Department of Education FY 2003 Performance and Accountability Report.

ERIC Educational Resources Information Center

Department of Education, Washington, DC.

This is a report on the progress of the U.S. Department of Education's accounting systems and management controls. Sections include: (1) Management's Discussion and Analysis; (2) Performance Details; (3) Financial Details; and (4) Other Statutorily Required Reports. Five appendixes are included along with a glossary of terms and a list of figures.…

Solar Parabolic Dish Annual Technology Evaluation Report

NASA Technical Reports Server (NTRS)

1983-01-01

The activities of the JPL Solar Thermal Power Systems Parabolic Dish Project for FY 1982 are summarized. Included are discussions on designs of module development including their concentrator, receiver, and power conversion subsystems. Analyses and test results, along with progress on field tests, Small Community Experiment System development, and tests at the Parabolic Dish Test Site are also included.

Annual Research Progress Report, FY 1980.

DTIC Science & Technology

1980-10-01

surgical procedure was documented on video tape for future reference. CONCLUSIONS A surgical procedure was developed to expose the dorsal spinal...cACicor M uW o , nbeloI *mpo,8 nnl PoRN 1AQQ PREVIOUS EDIOTIONS OF THIS FORM ARE ORSOLYTE DO FORMS 1498A. I NOV GO ABSTRACT PROJECT NO. 3S162772A814

Control Design for an Advanced Geared Turbofan Engine

NASA Technical Reports Server (NTRS)

Chapman, Jeffryes W.; Litt, Jonathan S.

2017-01-01

This paper describes the design process for the control system of an advanced geared turbofan engine. This process is applied to a simulation that is representative of a 30,000 lbf thrust class concept engine with two main spools, ultra-high bypass ratio, and a variable area fan nozzle. Control system requirements constrain the non-linear engine model as it operates throughout its flight envelope of sea level to 40,000 ft and from 0 to 0.8 Mach. The control architecture selected for this project was developed from literature and reflects a configuration that utilizes a proportional integral controller integrated with sets of limiters that enable the engine to operate safely throughout its flight envelope. Simulation results show the overall system meets performance requirements without exceeding system operational limits.

Ocean Observations with EOS/MODIS: Algorithm Development and Post Launch Studies

NASA Technical Reports Server (NTRS)

Gordon, Howard R.; Conboy, Barbara (Technical Monitor)

1999-01-01

This separation has been logical thus far; however, as launch of AM-1 approaches, it must be recognized that many of these activities will shift emphasis from algorithm development to validation. For example, the second, third, and fifth bullets will become almost totally validation-focussed activities in the post-launch era, providing the core of our experimental validation effort. Work under the first bullet will continue into the post-launch time frame, driven in part by algorithm deficiencies revealed as a result of validation activities. Prior to the start of the 1999 fiscal year (FY99) we were requested to prepare a brief plan for our FY99 activities. This plan is included as Appendix 1. The present report describes the progress made on our planned activities.

PBX 9502 Gas Generation Progress Report FY17

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holmes, Matthew David; Erickson, Michael Andrew Englert

The self-ignition (“cookoff”) behavior of PBX 9502 depends on the dynamic evolution of gas permeability and physical damage in the material. The time-resolved measurement of product gas generation yields insight regarding the crucial properties that dominate cookoff behavior. We report on small-scale laboratory testing performed in FY17, in which small unconfined samples of PBX 9502 were heated in a small custom-built sealed pressure vessel to self-ignition. We recorded time-lapse video of the evolving physical changes in the sample, quasi-static long-duration pressure rise, then high-speed video and dynamic pressure rise of the cookoff event. We report the full pressure attained duringmore » the cookoff of a 1.02g sample in a free volume of 62.5 cm 3.« less

United States Nuclear Data Program (USNDP)

Science.gov Websites

Report FY 2016 Annual Report FY 2015 Annual Report FY 2014 Annual Report FY 2013 Annual Report FY 2012 Annual Report FY 2011 Annual Report FY 2010 Annual Report FY 2009 Annual Report FY 2008 Annual Report FY 2007 Annual Report FY 2006 Annual Report FY 2005 Annual Report FY 2004 Final Report FY 2003 Final

Identification of a prospective early motor progression cluster of Parkinson's disease: Data from the PPMI study.

PubMed

Vavougios, George D; Doskas, Triantafyllos; Kormas, Constantinos; Krogfelt, Karen A; Zarogiannis, Sotirios G; Stefanis, Leonidas

2018-04-15

The aim of our study is to phenotype PD motor progression, and to detect whether serum, cerebrospinal fluid (CSF), neuroimaging biomarkers and neuropsychological measures characterize PD motor progression phenotypes. We defined motor progression as a difference of at least one point in the Hoehn & Yahr (H&Y) scale between the baseline (Visit 0, V0), 12 months (Visit 04, V04) and 36 months (Visit 08, V08) milestones of the Progression Markers Initiative (PPMI) study. H&Y progression events were recorded at each milestone in order to be used as cluster analysis variables, in order to produce progression phenotypes. Subsequently, cross-cluster comparisons prior to and following (pairwise) propensity score matching were performed in order to assess phenotype - defining characteristics. Four progression clusters where identified: SPPD: Secondarily Progressive PD, H&Y progression between V04 and V08; EPPD: Early Progressive PD. H&Y progression between V0 and V04; NPPD: Non Progressive PD, no H&Y progression; MIPD: Minimally Improving PD, i.e. Minimal H&Y improvement H&Y progression between V04 and V08;. Independent Samples Mann Whitney U tests determined CSF aSyn (p = 0.006, adj p-value = 0.036. I) and Semantic Animal fluency T-score (SFT, p = 0.003, adjusted p-value = 0.016.) as statistically significant cross-cluster characteristics. Following Propensity Score Matching, SFT, Hopkins Verbal Learning Test (Retention/Recall), Serum IGF1, CSF aSyn, DaT-SPECT binding ratios (SBRs) and the Benton Judgement of Line Orientation Test (BJLOT) were determined as statistically significant predictors of cluster differentiation (p < 0.05). SFT, Serum IGF1, CSF aSyn and DaT-SPECT-derived, basal ganglia Striatal Binding Ratios warrant further investigation as possible motor progression biomarkers. Copyright © 2018 Elsevier B.V. All rights reserved.

ALSSAT Development Status

NASA Technical Reports Server (NTRS)

Yeh, H. Y. Jannivine; Brown, Cheryl B.; Jeng, Frank F.; Anderson, Molly; Ewert, Michael K.

2009-01-01

The development of the Advanced Life Support (ALS) Sizing Analysis Tool (ALSSAT) using Microsoft(Registered TradeMark) Excel was initiated by the Crew and Thermal Systems Division (CTSD) of Johnson Space Center (JSC) in 1997 to support the ALS and Exploration Offices in Environmental Control and Life Support System (ECLSS) design and studies. It aids the user in performing detailed sizing of the ECLSS for different combinations of the Exploration Life support (ELS) regenerative system technologies. This analysis tool will assist the user in performing ECLSS preliminary design and trade studies as well as system optimization efficiently and economically. The latest ALSSAT related publication in ICES 2004 detailed ALSSAT s development status including the completion of all six ELS Subsystems (ELSS), namely, the Air Management Subsystem, the Biomass Subsystem, the Food Management Subsystem, the Solid Waste Management Subsystem, the Water Management Subsystem, and the Thermal Control Subsystem and two external interfaces, including the Extravehicular Activity and the Human Accommodations. Since 2004, many more regenerative technologies in the ELSS were implemented into ALSSAT. ALSSAT has also been used for the ELS Research and Technology Development Metric Calculation for FY02 thru FY06. It was also used to conduct the Lunar Outpost Metric calculation for FY08 and was integrated as part of a Habitat Model developed at Langley Research Center to support the Constellation program. This paper will give an update on the analysis tool s current development status as well as present the analytical results of one of the trade studies that was performed.

Computational algebraic geometry for statistical modeling FY09Q2 progress.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, David C.; Rojas, Joseph Maurice; Pebay, Philippe Pierre

2009-03-01

This is a progress report on polynomial system solving for statistical modeling. This is a progress report on polynomial system solving for statistical modeling. This quarter we have developed our first model of shock response data and an algorithm for identifying the chamber cone containing a polynomial system in n variables with n+k terms within polynomial time - a significant improvement over previous algorithms, all having exponential worst-case complexity. We have implemented and verified the chamber cone algorithm for n+3 and are working to extend the implementation to handle arbitrary k. Later sections of this report explain chamber cones inmore » more detail; the next section provides an overview of the project and how the current progress fits into it.« less

U.S. Army Aeromedical Research Laboratory Annual Progress Report: FY 84

DTIC Science & Technology

1984-10-01

OFFICE SYMBOL 7a. NAME OF MONITORING ORGANIZATION U.S. Army Aeromedical Research (if applicable) U.S. Army Medical Research and Developmmt Laboratory...Group for Aerospace Research and Develop- ment--Aerospace Medical Panel ......................... 105 American National Standards Institute (ANSI...aviation specialities. Assists other US Army Medical Research and Development Command (USAMRDC) laboratories and institutes in research on the

Early Warning Report: EPA Region 9 Should Withhold Award of the Fiscal Year 2015 Drinking Water State Revolving Fund Grant to the Hawaii Department of Health

EPA Pesticide Factsheets

Report #15-P-0298, September 28, 2015. Due to a Notice of Non-Compliance issued to the Hawaii DOH and lack of adequate progress on a corrective action plan, the EPA should withhold about $8.8 million in FY 2015 DWSRF capitalization grant funds.

Annual Progress Report, Fiscal Year 1980.

DTIC Science & Technology

1980-09-30

FY79,O) The Incidence of Visual-%otor Perceptual Problem in Persons with Traumatic Hand Injuries ............................................... Work...Mena 1H. Fine Structure and biochemistry of Brain Idema in Regional Cerebral Ischemia. in Cerebrovascular DisezLses, Raven Press: New’ York, 1979...JAMA 243:1526, 1980. SAwdh ,er ;I: Risks of Contraception with the Intrauterine Device. Accepted for publication in Journal Pediatrics. ,’eir %4R

Annual Progress Report, Fiscal Year 1981.

DTIC Science & Technology

1981-09-30

Ticlopidine Hydrochloride - A Clinical Trial in Patients with Transient Cerebral or Monocular Ischemic Attacks ............... 138 Work Unit No. 81/57...Hand Injuries .................................... 180 Work Unit No. 80/06 (FY8O,C) Evaluation of Antagonistic Knee Flexors and Extensors During Prone...Preventable Training Injury : Accepted for publication in Military Medicine(C). Smith WR, Lee SH, Vichick DA: Evaluation of Antagonistic Knee Flexors and

Annual Progress Report FY-82. Volume II.

DTIC Science & Technology

1982-01-01

subjective judgments, binaural amplification TITLE OF PROJECT: Subjective Comparisons of Binaural vs. Monaural Amplification PRINCIPAL INVESTIGATOR(S...REPORT STUDY OBJECTIVE: The purpose of this study is to determine (1) the consis- tency of subjective differences noted between binaural and monaural...candidates seen at WRAMC have been reviewed to determine rationale for preferences of mon- aural vs. binaural amplification. Comparisons are being made of

Annual Research Progress Report, FY 1991

DTIC Science & Technology

1991-09-30

59 86/114 0 Natural History of HTLV-III Infection and Disease in a United States Military Community (PR) ............... . ............ 60 86/120 0...Malignant Lymphomas ..................... 142 90/147 0 SWOG 8819 Central Lymphoma Repository Tissue Procurement Protocol ........................... 143 90...Adjuvant Chemo- therapy with or without Endocrine Therapy in High- Risk, Node Negative Breast Cancer Patients and a Natural History Followup Study in Low

Annual Progress Report, FY 1980, 1 October 1979 - 30 September 1980,

DTIC Science & Technology

1980-10-01

coordinating an integrated pest management program, and constructing initial pilot prototypes, test models, and pro- ducing limited quantities of medical...Screening Test Based on the Ventilatory Responses of Fish . . . . . . . a & a . . . . 25 Chemistry and Molecular Biology of the Disinfection Process...Sink Unit, Surgical, Field (NSN 6545-00-935-4056), Engineering Evaluation of . . . . . . . . . . . . . . . . . . 69 Technical Feasibility Testing (TFT

Clinical Investigation Program Annual Progress Report

DTIC Science & Technology

1989-09-30

initiatives for the study of relatedness of bacterial and HLA antigens as they influence autoimmune diseases. Microbiology Service - FY 89 An in-house...1030 87/103 0 Identification of Those at Risk for Osteoporotic Hip Fractures, by an Noninvasive Measurement (P) (PR)... 105 87/104 0 SWOG 8600 - A...233 82/302 0 The Evaluation of Recently Introduced, Commercially Available Clinical Microbiology Products for Possible

Planetary geomorphology research: FY 1990-1991

NASA Technical Reports Server (NTRS)

Malin, M. C.

1991-01-01

Progress in the following research areas is discussed: (1) volatile ice sublimation in a simulated Martian polar environment; (2) a global synthesis of Venusian tectonics; (3) a summary of nearly a decade of field studies of eolian processes in cold volcanic deserts; and (4) a model for interpretation of Martian sediment distribution using Viking observations. Some conclusions from the research are presented.

Annual Research Progress Report FY 92.

DTIC Science & Technology

1993-01-11

and Toxic Exposures B ronchial m ucin .................................................................. 12 Enriquez, John 1 .: 90/13 (T) The Effect of...Bast RC: Fibronectin is an immunosuppressive Pearl W, Zeballos R, Gregors G, Connery S, substance associated with epithelial ovarian Weisman 1 : Effects ...Symposium. 30 Sonthofen, Germany, Apr 92. Apr-03 May 92. Donovan M: Maxillofacial Reconstruction Using Weisman 1 : Presence of SOT and the Effect on

JaK/STAT Inhibition to Prevent Post-Traumatic Epileptogenesis

DTIC Science & Technology

2014-09-01

Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Traumatic Brain Injury (TBI) is a well-established inducer of temporal lobe epilepsy (TLE...INTRODUCTION: This research addresses the FY10 PRMRP topic area of Epilepsy . Traumatic Brain Injury (TBI) is a well- established etiology of temporal ... lobe epilepsy (TLE), a frequently medically intractable and often progressive epilepsy syndrome. Much evidence indicates that abnormalities in

LLE 1998 annual report, October 1997--September 1998. Inertial fusion program and National Laser Users` Facility program

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1999-01-01

This report summarizes research at the Laboratory for Laser Energetics (LLE), the operation of the National Laser Users` Facility (NLUF), and programs involving the education of high school, undergraduate, and graduate students for FY98. Research summaries cover: progress in laser fusion; diagnostic development; laser and optical technology; and advanced technology for laser targets.

University of Illinois at Urbana-Champaign, Materials Research Laboratory progress report for FY 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-07-01

This interdisciplinary laboratory in the College of Engineering support research in areas of condensed matter physics, solid state chemistry, and materials science. These research programs are developed with the assistance of faculty, students, and research associates in the departments of Physics, Materials Science and Engineering, chemistry, Chemical Engineering, Electrical Engineering, Mechanical Engineering, and Nuclear Engineering.

Atmosphere Resource Recovery and Environmental Monitoring Trace Contaminant Control Through FY 2012

NASA Technical Reports Server (NTRS)

Perry, J. L.; Pruitt, M. W.; Wheeler, R. M.; Monje, O.

2013-01-01

Trace contaminant control has been a concern of spacecraft designers and operators from early in the progression of manned spaceflight. Significant technological advancement has occurred since the first designs were implemented in the 1960s, culminating in the trace contaminant control system currently in use aboard the International Space Station as part of the atmosphere revitalization system.

Public Health Preparedness Funding: Key Programs and Trends From 2001 to 2017.

PubMed

Watson, Crystal R; Watson, Matthew; Sell, Tara Kirk

2017-09-01

To evaluate trends in funding over the past 16 years for key federal public health preparedness and response programs at the US Department of Health and Human Services, to improve understanding of federal funding history in this area, and to provide context for future resource allocation decisions for public health preparedness. In this 2017 analysis, we examined the funding history of key federal programs critical to public health preparedness by reviewing program budget data collected for our annual examination of federal funding for biodefense and health security programs since fiscal year (FY) 2001. State and local preparedness at the Centers for Disease Control and Prevention initially received $940 million in FY2002 and resulted in significant preparedness gains, but funding levels have since decreased by 31%. Similarly, the Hospital Preparedness Program within the Office of the Assistant Secretary for Preparedness and Response was funded at a high of $515 million in FY2003, but funding was reduced by 50%. Investments in medical countermeasure development and stockpiling remained relatively stable. The United States has made significant progress in preparing for disasters and advancing public health infrastructure. To enable continued advancement, federal funding commitments must be sustained.

Public Health Preparedness Funding: Key Programs and Trends From 2001 to 2017

PubMed Central

Sell, Tara Kirk

2017-01-01

Objectives. To evaluate trends in funding over the past 16 years for key federal public health preparedness and response programs at the US Department of Health and Human Services, to improve understanding of federal funding history in this area, and to provide context for future resource allocation decisions for public health preparedness. Methods. In this 2017 analysis, we examined the funding history of key federal programs critical to public health preparedness by reviewing program budget data collected for our annual examination of federal funding for biodefense and health security programs since fiscal year (FY) 2001. Results. State and local preparedness at the Centers for Disease Control and Prevention initially received $940 million in FY2002 and resulted in significant preparedness gains, but funding levels have since decreased by 31%. Similarly, the Hospital Preparedness Program within the Office of the Assistant Secretary for Preparedness and Response was funded at a high of $515 million in FY2003, but funding was reduced by 50%. Investments in medical countermeasure development and stockpiling remained relatively stable. Conclusions. The United States has made significant progress in preparing for disasters and advancing public health infrastructure. To enable continued advancement, federal funding commitments must be sustained. PMID:28892451

Lead Slowing-Down Spectrometry Time Spectral Analysis for Spent Fuel Assay: FY11 Status Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kulisek, Jonathan A.; Anderson, Kevin K.; Bowyer, Sonya M.

2011-09-30

Developing a method for the accurate, direct, and independent assay of the fissile isotopes in bulk materials (such as used fuel) from next-generation domestic nuclear fuel cycles is a goal of the Office of Nuclear Energy, Fuel Cycle R&D, Material Protection and Control Technology (MPACT) Campaign. To meet this goal, MPACT supports a multi-institutional collaboration, of which PNNL is a part, to study the feasibility of Lead Slowing Down Spectroscopy (LSDS). This technique is an active nondestructive assay method that has the potential to provide independent, direct measurement of Pu and U isotopic masses in used fuel with an uncertaintymore » considerably lower than the approximately 10% typical of today's confirmatory assay methods. This document is a progress report for FY2011 PNNL analysis and algorithm development. Progress made by PNNL in FY2011 continues to indicate the promise of LSDS analysis and algorithms applied to used fuel. PNNL developed an empirical model based on calibration of the LSDS to responses generated from well-characterized used fuel. The empirical model, which accounts for self-shielding effects using empirical basis vectors calculated from the singular value decomposition (SVD) of a matrix containing the true self-shielding functions of the used fuel assembly models. The potential for the direct and independent assay of the sum of the masses of 239Pu and 241Pu to within approximately 3% over a wide used fuel parameter space was demonstrated. Also, in FY2011, PNNL continued to develop an analytical model. Such efforts included the addition of six more non-fissile absorbers in the analytical shielding function and the non-uniformity of the neutron flux across the LSDS assay chamber. A hybrid analytical-empirical approach was developed to determine the mass of total Pu (sum of the masses of 239Pu, 240Pu, and 241Pu), which is an important quantity in safeguards. Results using this hybrid method were of approximately the same accuracy as the pure empirical approach. In addition, total Pu with much better accuracy with the hybrid approach than the pure analytical approach. In FY2012, PNNL will continue efforts to optimize its empirical model and minimize its reliance on calibration data. In addition, PNNL will continue to develop an analytical model, considering effects such as neutron-scattering in the fuel and cladding, as well as neutrons streaming through gaps between fuel pins in the fuel assembly.« less

High Technology Engineering Services, Inc. fiscal year 1993 and 1994 research and development report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This document has been prepared by the Professional Staff of High Technology Engineering Services, Inc. (HTES) for fiscal year (FY) 1993. Work was performed for various aspects of mechanical design and analysis, materials development and properties quantification, nuclear environment performance, and engineering program prioritization. The tasks enumerated in the subcontract, attachment B are: 1. Assist in preparation of final R&D report for SDC detector development. 2. Subcontractor shall make contributions to the development of innovative processes for the manufacture of quasi- isotropic, enhanced thermal conductivity compression molded advanced composite materials. 3. Perform finite element analysis as it relates to themore » Superconducting Super Collider Silicon Tracking System, both mechanical and thermal, of very thin section advanced composite materials. 4. Subcontractor shall perform technical studies, reviews, and assessments of the current program for advanced composites materials processing and testing. 5. Subcontractor shall attend meetings and discussions as directed by MEE-12 technical representative. Unfortunately during the course of FY93, technical and financial challenges prevailed against the aggressive goals set for the program. In point of fact, less than 25% of the contract value was able to be expended due to technical delays and programmatic funding cuts. Also, contracting difficulties with the SSC Lab and financial burdens at Los Alamos totally stopped progress on the subject subcontract during the whole of FY94. This was a great blow to me and the HTES, Inc. technical staff. Despite the negative influences over the years, significant progress was made in materials properties quantification and development of essential research and development documentation. The following brief report and attendant appendices will address these achievements.« less

Reality Check Algorithm for Complex Sources in Early Warning

NASA Astrophysics Data System (ADS)

Karakus, G.; Heaton, T. H.

2013-12-01

In almost all currently operating earthquake early warning (EEW) systems, presently available seismic data are used to predict future shaking. In most cases, location and magnitude are estimated. We are developing an algorithm to test the goodness of that prediction in real time. We monitor envelopes of acceleration, velocity, and displacement; if they deviate significantly from the envelope predicted by Cua's envelope gmpe's then we declare an overfit (perhaps false alarm) or an underfit (possibly a larger event has just occurred). This algorithm is designed to provide a robust measure and to work as quickly as possible in real-time. We monitor the logarithm of the ratio between the envelopes of the ongoing observed event and the envelopes derived from the predicted envelopes of channels of ground motion of the Virtual Seismologist (VS) (Cua, G. and Heaton, T.). Then, we recursively filter this result with a simple running median (de-spiking operator) to minimize the effect of one single high value. Depending on the result of the filtered value we make a decision such as if this value is large enough (e.g., >1), then we would declare, 'that a larger event is in progress', or similarly if this value is small enough (e.g., <-1), then we would declare a false alarm. We design the algorithm to work at a wide range of amplitude scales; that is, it should work for both small and large events.

Regulation of nuclear envelope dynamics via APC/C is necessary for the progression of semi-open mitosis in Schizosaccharomyces japonicus.

PubMed

Aoki, Keita; Shiwa, Yuh; Takada, Hiraku; Yoshikawa, Hirofumi; Niki, Hironori

2013-09-01

Three types of mitosis, which are open, closed or semi-open mitosis, function in eukaryotic cells, respectively. The open mitosis involves breakage of the nuclear envelope before nuclear division, whereas the closed mitosis proceeds with an intact nuclear envelope. To understand the mechanism and significance of three types of mitotic division in eukaryotes, we investigated the process of semi-open mitosis, in which the nuclear envelope is only partially broken, in the fission yeast Schizosaccharomyces japonicus. In anaphase-promoting complex/cyclosome (APC/C) mutants of Sz. japonicus, the nuclear envelope remained relatively intact during anaphase, resulting in impaired semi-open mitosis. As a suppressor of apc2 mutant, a mutation of Oar2, which was a 3-oxoacyl-[acyl carrier protein] reductase, was obtained. The level of the Oar2, which had two destruction-box motifs recognized by APC/C, was increased in APC/C mutants. Furthermore, the defective semi-open mitosis observed in an apc2 mutant was restored by mutated oar2+. Based on these findings, we propose that APC/C regulates the dynamics of the nuclear envelope through degradation of Oar2 dependent on APC/C during the metaphase-to-anaphase transition of semi-open mitosis in Sz. japonicus. © 2013 The Authors Genes to Cells © 2013 by the Molecular Biology Society of Japan and Wiley Publishing Asia Pty Ltd.

Potent Autologous and Heterologous Neutralizing Antibody Responses Occur in HIV-2 Infection across a Broad Range of Infection Outcomes

PubMed Central

Aasa-Chapman, Marlén; Cotten, Matthew; Hué, Stéphane; Robinson, James; Bibollet-Ruche, Frederic; Sarge-Njie, Ramu; Berry, Neil; Jaye, Assan; Aaby, Peter; Whittle, Hilton; Rowland-Jones, Sarah; Weiss, Robin

2012-01-01

Few studies have explored the role of neutralizing antibody (NAb) responses in controlling HIV-2 viremia and disease progression. Using a TZM-bl neutralization assay, we assessed heterologous and autologous NAb responses from a community cohort of HIV-2-infected individuals with a broad range of disease outcomes in rural Guinea-Bissau. All subjects (n = 40) displayed exceptionally high heterologous NAb titers (50% inhibitory plasma dilution or 50% inhibitory concentration [IC50], 1:7,000 to 1:1,000,000) against 5 novel primary HIV-2 envelopes and HIV-2 7312A, whereas ROD A and 3 primary envelopes were relatively resistant to neutralization. Most individuals also showed high autologous NAb against contemporaneous envelopes (78% of plasma-envelope combinations in 69 envelopes from 21 subjects), with IC50s above 1:10,000. No association between heterologous or autologous NAb titer and greater control of HIV-2 was found. A subset of envelopes was found to be more resistant to neutralization (by plasma and HIV-2 monoclonal antibodies). These envelopes were isolated from individuals with greater intrapatient sequence diversity and were associated with changes in potential N-linked glycosylation sites but not CD4 independence or CXCR4 use. Plasma collected from up to 15 years previously was able to potently neutralize recent autologous envelopes, suggesting a lack of escape from NAb and the persistence of neutralization-sensitive variants over time, despite significant NAb pressure. We conclude that despite the presence of broad and potent NAb responses in HIV-2-infected individuals, these are not the primary forces behind the dichotomous outcomes observed but reveal a limited capacity for adaptive selection and escape from host immunity in HIV-2 infection. PMID:22072758

MISR UAE2 Aerosol Versioning

Atmospheric Science Data Center

2013-03-21

... The "Beta" designation means particle microphysical property validation is in progress, uncertainty envelopes on particle size distribution, ... UAE-2 campaign activities are part of the validation process, so two versions of the MISR aerosol products are included in this ...

2017-04-28_B61-12-Program Overview(OUO).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daniels, Vonceil

2017-04-01

The B61-12 LEP is currently executing Phase 6.4 Production Engineering with a focus on qualification and preproduction activities. All major milestones have been successfully completed to date. Component Final Design Reviews (FDRs) continue in FY17, with 19 of 38 complete as of April 28. A series of normal and abnormal environments tests occurred in the first half of FY17, and the first qualification flight test on an F-16 was executed in March. Two F-15 qualification flight tests are planned in August. To support Pantex readiness, the first all-up-round (AUR) trainer builds were completed in December 2016. Progress is ongoing towardmore » closure of Air Force Nuclear Weapons Center (tailkit) and Los Alamos National Laboratory interface gaps, and resolution of producibility challenges with the Kansas City National Security Campus (KCNSC).« less

NOAA administrator reviews agency progress and challenges

NASA Astrophysics Data System (ADS)

Showstack, Randy

2011-12-01

The approach of the new year is a traditional time to tally up successes, failures, and the path ahead. Jane Lubchenco, administrator of the U.S. National Oceanic and Atmospheric Administration (NOAA), examined some agency advances and significant challenges during the 7 December Union Agency Lecture at the AGU Fall Meeting, during a press briefing, and in an interview with Eos. Lubchenco focused on several key areas including the concern about monitoring, mitigating, and managing extreme events; budgetary pressures the agency faces in current fiscal year (FY) 2012 and in FY 2013, with President Barack Obama on 18 November having signed into law a bill, HR 2112, following congressional agreement on a budget legislation conference report; and NOAA's newly released scientific integrity policy (see "NOAA issues scientific integrity policy," Eos Trans. AGU, 92(50), 467, doi:10.1029/2011EO500004, 2011).

Photovoltaic Subcontract Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Surek, Thomas; Catalano, Anthony

1993-03-01

This report summarizes the fiscal year (FY) 1992 progress of the subcontracted photovoltaic (PV) research and development (R D) performed under the Photovoltaic Advanced Research and Development Project at the National Renewable Energy Laboratory (NREL)-formerly the Solar Energy Research Institute (SERI). The mission of the national PV program is to develop PV technology for large-scale generation of economically competitive electric power in the United States. The technical sections of the report cover the main areas of the subcontract program: the Crystalline Materials and Advanced Concepts project, the Polycrystalline Thin Films project, Amorphous Silicon Research project, the Photovoltaic Manufacturing Technology (PVMaT)more » project, PV Module and System Performance and Engineering project, and the PV Analysis and Applications Development project. Technical summaries of each of the subcontracted programs provide a discussion of approaches, major accomplishments in FY 1992, and future research directions.« less

Pacific Northwest Laboratory annual report for 1979 to the DOE Assistant Secretary for Environment. Part 5. Environmental assessment, control, health, and safety

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baalman, R.W.; Dotson, C.W.

1980-02-01

Part 5 of the 1979 Annual Report to the Department of Energy Assistant Secretary for the Environment presents Pacific Northwest Laboratory's progress on work performed for the Office of Technology Impacts, the Office of Environmental Compliance and Overview, and the Office of Health and Environmental Research. The report is in four sections, corresponding to the program elements: technology impacts, environmental control engineering, operational and environmental compliance, and human health studies. In each section, articles describe progress made during FY 1979 on individual projects.

FY 2014 Annual Progress Report - Advanced Combustion Engine Research and Development (Book)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

In the past year, the DOE Hydrogen Program (the Program) made substantial progress toward its goals and objectives. The Program has conducted comprehensive and focused efforts to enable the widespread commercialization of hydrogen and fuel cell technologies in diverse sectors of the economy. With emphasis on applications that will effectively strengthen our nation's energy security and improve our stewardship of the environment, the Program engages in research, development, and demonstration of critical improvements in the technologies. Highlights of the Program's accomplishments can be found in the sub-program chapters of this report.

AGU scientists meet with legislators during Geosciences Congressional Visits Day

NASA Astrophysics Data System (ADS)

Uhlenbrock, Kristan

2011-10-01

This year marks the fourth annual Geosciences Congressional Visits Day (Geo-CVD), in which scientists from across the nation join together in Washington, D. C., to meet with their legislators to discuss the importance of funding for Earth and space sciences. AGU partnered with seven other Earth and space science organizations to bring more than 50 scientists, representing 23 states, for 2 days of training and congressional visits on 20-21 September 2011. As budget negotiations envelop Congress, which must find ways to agree on fiscal year (FY) 2012 budgets and reduce the deficit by $1.5 trillion over the next 10 years, Geo-CVD scientists seized the occasion to emphasize the importance of federally funded scientific research as well as science, technology, engineering, and math (STEM) education. Cuts to basic research and STEM education could adversely affect innovation, stifle future economic growth and competitiveness, and jeopardize national security.

Recent Progress in Understanding Coxsackievirus Replication, Dissemination, and Pathogenesis

PubMed Central

Sin, Jon; Mangale, Vrushali; Thienphrapa, Wdee; Gottlieb, Roberta A.; Feuer, Ralph

2015-01-01

Coxsackieviruses (CVs) are relatively common viruses associated with a number of serious human diseases, including myocarditis and meningo-encephalitis. These viruses are considered cytolytic yet can persist for extended periods of time within certain host tissues requiring evasion from the host immune response and a greatly reduced rate of replication. A member of Picornaviridae family, CVs have been historically considered non-enveloped viruses – although recent evidence suggest that CV and other picornaviruses hijack host membranes and acquire an envelope. Acquisition of an envelope might provide distinct benefits to CV virions, such as resistance to neutralizing antibodies and efficient nonlytic viral spread. CV exhibits a unique tropism for progenitor cells in the host which may help to explain the susceptibility of the young host to infection and the establishment of chronic disease in adults. CVs have also been shown to exploit autophagy to maximize viral replication and assist in unconventional release from target cells. In this article, we review recent progress in clarifying virus replication and dissemination within the host cell, identifying determinants of tropism, and defining strategies utilized by the virus to evade the host immune response. Also, we will highlight unanswered questions and provide future perspectives regarding the potential mechanisms of CV pathogenesis. PMID:26142496

BRAC, What Will it Cost

DTIC Science & Technology

1992-04-10

Devens - Fort Huachuca FY 91 FY 95 Fort McClellan FY 92 FY 96 Fort Chaffee FY 92 FY 97 Cameron Station FY 91 FY 95 53 Stand Alone Housing Sites FY 90 FY...Army, Headquarters Forces Command, &as Realianment and Closure Implementation Plan - Fort Devens Closure Package, Implementation Plan, Fort McPherson, GA...Classification) RAC , What Will It Cost? 12. PERSONAL AUTHOR(S) TLIN, Robert B. LTC, USA 13. TYPE OF REPORT 13b. TIME COVERED 14. DATE OF REPORT (Year

Proposed Criteria for Evaluation of the Reliability Improvement Warranty Concept.

DTIC Science & Technology

1980-06-01

future applications of AFT thesis research. Please return canpleted questionnaires to: AIT/ LSH Cflnesis Feedback), Wright-Patterson AFB, Ohio 45433. 1 ... 1 Overview. .................... 1 Background. ................... 4 II. PROBLEM DEFINITION. ................ 7 Evaluation Progress ............... 7...maintainability of its weapon sys- tem’s equipment (17: 1 ). In an effort to achieve this end, the Air Force, in FY 1969, first applied the concept of the

US Army Institute of Surgical Research Annual Research Progress Report, FY 1980.

DTIC Science & Technology

1980-10-01

strain of 1244. EXAMINATION OF ANTI-PSEUDOMONAS AERUGINOSA ACTIVITY OF CEFSULODIN Most cephalosporin antibiotics, despite broad antibacterial spec- tra...documents the clinical and laboratory activities of the US Army Institute of Surgical Research during the fiscal year 1980. These activities include...of irreversible shock. Clinical care is jeopardized and the continued involvement of clinicians in investigative activities is virtually impossible

US Army Medical Bioengineering Research and Development Laboratory Annual Progress Report for FY 82.

DTIC Science & Technology

1982-10-01

DISTRIBUTION UNLIMITED. US ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND Fort Detrick Frederick, MD 21701 r-. , -. , 4 .. %! NOTICE Disclaimer The findings...CMPLTINGORM .REPORT 4UER 2. P3. RECIPIENT’S CATALOG NUMBER MEDDH-28 (RI) _____________ 4 . TITLE (mnd ,bu .*o) S. TYPE OF REPORT A PERIOD COVERED US Army Medical...21 Trihalomethane (THM) Degradation ......................... 23 Silver Chloride Photovoltaic Cell

FY 2007 Progress Report for Upper Columbia United Tribes' Regional Coordination.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michel, D.R.

2008-12-15

This report is a summary of activities conducted over the fiscal year 2007 contract period to fulfill requirements to coordinate Upper Columbia United Tribes (UCUT) interests within the Columbia River Basin. This coordination was specific to the implementation of portions of the Integrated Fish and Wildlife Program within the purview of the Northwest Power and Conservation Council and Bonneville Power Administration.

Laboratory directed research and development. FY 1995 progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vigil, J.; Prono, J.

1996-03-01

This document presents an overview of Laboratory Directed Research and Development Programs at Los Alamos. The nine technical disciplines in which research is described include materials, engineering and base technologies, plasma, fluids, and particle beams, chemistry, mathematics and computational science, atmic and molecular physics, geoscience, space science, and astrophysics, nuclear and particle physics, and biosciences. Brief descriptions are provided in the above programs.

Laboratory Experiments on Bentonite Samples: FY16 Progress

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruth M. Tinnacher; Tournassat, Christophe; James A. Davis

2016-08-22

The primary goal of this study is to improve the understanding of U(VI) sorption and diffusion behavior in sodium-montmorillonite in order to support the development of realistic conceptual models describing these processes in performance assessment models while (1) accounting for potential changes in system conditions over time and space, (2) avoiding overly conservative transport predictions, and (3) using a minimum number of fitting parameters.

U.S. Army Aeromedical Research Laboratory Annual Progress Report Fiscal Year 2009

DTIC Science & Technology

2010-02-10

Warfighter. During FY09, the CADB investigated the effects of TBI, sleep deprivation, substance use /misuse (licit and illicit), pre- morbid ...and standard of visual aids and equipment used in these teaching sessions. ALSERP personnel also visited Auburn University as part of a USAARL...dismounted Warfighters. The IBB team uses various standardized and unique methods (e.g., epidemiological research, computer modeling , laboratory

US Army Medical Bioengineering Research and Development Laboratory Annual Progress Report for FY 84. Volume 1

DTIC Science & Technology

1984-10-01

develop pollution abatement procedures for Army munition plants and military installations.n, t ftr Laboratory is also actively engaged in the...FACILITIES The physical plant provides over 100,000 square feet for research, development, testing, and administrative activities . Space is...protection of industrial workers and thq surrounding community at Army-controlled, industry-operated munition plants . G Environmental Quality program

2010 Annual Progress Report DOE Hydrogen Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

This report summarizes the hydrogen and fuel cell R&D activities and accomplishments in FY2009 for the DOE Hydrogen Program, including the Hydrogen, Fuel Cells, and Infrastructure Technologies Program and hydrogen-related work in the Offices of Science; Fossil Energy; and Nuclear Energy, Science, and Technology. It includes reports on all of the research projects funded by the DOE Hydrogen Program between October 2009 and September 2010.

FY2011 Annual Progress Report for Vehicle and Systems Simulation and Testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2012-01-15

The VSST team's mission is to evaluate the technologies and performance characteristics of advanced automotive powertrain components and subsystems in an integrated vehicle systems context. These evaluations address light-, medium-, and heavy-duty vehicle platforms. This work is directed toward evaluating and verifying the targets of the VTP R&D teams and to providing guidance in establishing roadmaps for achievement of these goals.

The Navy’s Environmental Program and Opportunities in the Southwest

DTIC Science & Technology

2013-08-27

Achieve RIP for all High Priority IRP Sites FY14 •Achieve RC for 90% of IRP + MRP Sites FY18 •Achieve RC for 95% of IRP + MRP Sites FY21 9 NAVFAC Southwest...8/21/2013 ER,N IRP vs. MRP ($M) NAVFAC SW 0 10 20 30 40 50 60 70 FY 13 FY 14 FY 15 FY 16 FY 17 FY 18 FY 19 FY 20 FY 21 4 4 7 7 7 43 54 42 51...50 57 58 58 51 18 15 11 9 MRP IRP 10 NAVFAC Southwest Southwest ER,N Requirements Overall CTC: $766M ~54% IRP; ~46% MRP IRP , $411 MRP

Molecular characterization of the Fy(a-b-) phenotype in a Polish family.

PubMed

Karolak, Ewa; Grodecka, Magdalena; Suchanowska, Anna; Klausa, Elżbieta; Bochenek, Stanisława; Majorczyk, Edyta; Czerwiński, Marcin; Waśniowska, Kazimiera

2013-10-01

The Fy(a-b-) phenotype, very rare in Caucasians and defined by the homozygous FY(*)B-33 allele, is associated with the -33T>C mutation in the promoter region of the FY gene. The allele FY(*)X is correlated with weak expression of Fy(b) antigen due to 265C>T and 298G>A mutations in FY(*)B allele. The purpose of this study was molecular characterization of Fy blood group antigens in Fy(a-b-) members of a Polish family. High-resolution melting analysis was performed to detect single nucleotide polymorphisms in amplified fragments of the FY gene. The Fy(a-b-) phenotype in three siblings of the Polish family was caused by the FY(*)X/FY(*)B-33 genotype. Copyright © 2013 Elsevier Ltd. All rights reserved.

78 FR 11685 - Public Availability of FY 2011 Service Contract Inventory Analysis, FY 2012 Service Contract...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-19

... Analysis, FY 2012 Service Contract Inventory, and FY 2012 Service Contract Inventory Planned Analysis for... of the availability of the FY 2011 Service Contract Inventory Analysis, the FY 2012 Service Contract Inventory, and the FY 2012 Service Contract Inventory Planned Analysis. The FY 2011 inventory analysis...

First example of an FY*01 allele associated with weakened expression of Fya on red blood cells.

PubMed

Arndt, Patricia A; Horn, Trina; Keller, Jessica A; Heri, Suzanne M; Keller, Margaret A

2015-01-01

Duffy antigens are important in immunohematology. the reference allele for the Duffy gene (FY) is FY*02, which encodes Fy(b). An A>G single nucleotide polymorphism (SNP) at coding nucleotide (c.) 125 in exon 2 defines the FY*01 allele, which encodes the antithetical Fy(a). A C>T SNP at c.265 in the FY*02 allele is associated with weakening of Fy(b) expression on red blood cells (R BCs) (called Fy(x)). until recently, this latter change had not been described on a FY*01 background allele. Phenotype-matched units were desired for a multi-transfused Vietnamese fetus with α-thalassemia. Genotyping of the fetus using a microarray assay that interrogates three SNPs (c.1-67, c.125, and c.265) in FY yielded indeterminate results for the predicted Duffy phenotype. Genomic sequencing of FY exon 2 showed that the fetal sample had one wild-type FY*01 allele and one new FY*01 allele with the c.265C>T SNP, which until recently had only been found on the FY*02 allele. Genotyping performed on samples from the proband's parents indicated that the father had the same FY genotype as the fetus. Flow cytometry, which has been previously demonstrated as a useful method to study antigen strength on cells, was used to determine if this new FY*01 allele was associated with reduced Fy(a) expression on the father's RBCs. Median fluorescence intensity of the father's RBCs (after incubation with anti-FY(a) and fluorescein-labeled anti-IgG) was similar to known FY*01 heterozygotes. and significantly weaker than known FY*01 homozygotes. In conclusion, the fetus and father both had one normal FY*01 allele and one new FY*01W.01, is associated with weakened expression of Fy(a) on RBCs.

SURF IA Conflict Detection and Resolution Algorithm Evaluation

NASA Technical Reports Server (NTRS)

Jones, Denise R.; Chartrand, Ryan C.; Wilson, Sara R.; Commo, Sean A.; Barker, Glover D.

2012-01-01

The Enhanced Traffic Situational Awareness on the Airport Surface with Indications and Alerts (SURF IA) algorithm was evaluated in a fast-time batch simulation study at the National Aeronautics and Space Administration (NASA) Langley Research Center. SURF IA is designed to increase flight crew situation awareness of the runway environment and facilitate an appropriate and timely response to potential conflict situations. The purpose of the study was to evaluate the performance of the SURF IA algorithm under various runway scenarios, multiple levels of conflict detection and resolution (CD&R) system equipage, and various levels of horizontal position accuracy. This paper gives an overview of the SURF IA concept, simulation study, and results. Runway incursions are a serious aviation safety hazard. As such, the FAA is committed to reducing the severity, number, and rate of runway incursions by implementing a combination of guidance, education, outreach, training, technology, infrastructure, and risk identification and mitigation initiatives [1]. Progress has been made in reducing the number of serious incursions - from a high of 67 in Fiscal Year (FY) 2000 to 6 in FY2010. However, the rate of all incursions has risen steadily over recent years - from a rate of 12.3 incursions per million operations in FY2005 to a rate of 18.9 incursions per million operations in FY2010 [1, 2]. The National Transportation Safety Board (NTSB) also considers runway incursions to be a serious aviation safety hazard, listing runway incursion prevention as one of their most wanted transportation safety improvements [3]. The NTSB recommends that immediate warning of probable collisions/incursions be given directly to flight crews in the cockpit [4].

Factors affecting ewe performance in a crossbred dairy sheep research flock in the United States.

PubMed

Murphy, T W; Berger, Y M; Holman, P W; Baldin, M; Burgett, R L; Thomas, D L

2017-05-01

The Spooner Agricultural Research Station operated the only dairy sheep research flock in North America through 2016. The original nondairy ewe flock was "bred up" to a crossbred dairy flock through the use of rams and semen of the East Friesian (EF) and Lacaune (LA) dairy breeds. The objective of this study was to determine the environmental and nonadditive genetic effects that influence performance of dairy ewes. The traits analyzed were 180 d adjusted milk (180d MY), fat (180d FY), and protein (180d PY) yields, percentage fat (%F) and protein (%P) in milk, lactation average somatic cell score (LSCS), and number of lambs born per ewe lambing (NLB). The univariate repeatability models included the fixed effects of year of lambing, age, weaning system (except for the trait of NLB), individual breed composition, and individual retained heterosis along with the random additive genetic, permanent environmental, and residual effects. Estimates of heritability were moderate for 180d MY (0.32 ± 0.04), 180d FY (0.26 ± 0.04), and 180d PY (0.29 ± 0.04), high for %F (0.54 ± 0.04) and %P (0.61 ± 0.04), and low for LSCS (0.12 ± 0.03) and NLB (0.08 ± 0.02). Ewes that reared their lambs had lower ( < 0.01) 180d MY, 180d FY, 180d PY, %F, and %P and higher ( < 0.001) LSCS than ewes that had their lambs removed shortly after parturition. Relative to nondairy breeding, EF and LA breeding had positive ( < 0.001) effects on 180d MY, 180d FY, and 180d PY, but a negative ( < 0.03) effect on %P. Purebred EF ewes were predicted to have lower ( < 0.001) %F than purebred LA or nondairy ewes. Purebred LA ewes were predicted to have a higher ( < 0.001) LSCS than purebred EF or nondairy ewes. Purebred EF ewes were expected to be more ( < 0.001) prolific than purebred LA or nondairy ewes. Individual retained heterosis had a favorable ( < 0.01) effect on 180d MY, 180d FY, 180d PY, and NLB. Knowledge of the factors affecting dairy ewe performance are important for dairy sheep producers to make more informed husbandry and breeding decisions.

Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India.

PubMed

Chittoria, Anita; Mohanty, Sujata; Jaiswal, Yogesh Kumar; Das, Aparup

2012-01-01

The Duffy (Fy) antigens act as receptors for chemokines as well as for Plasmodium vivax to invade human RBCs. A recent study has correlated the occurrence of the FY*A allele of Duffy gene with decreased susceptibility to vivax malaria, but no epidemiological correlation between the distribution of FY*A allele and incidences of vivax malaria has been established so far. Furthermore, if such correlations exist, whether natural selection has mediated the association, is an important question. Since India is highly endemic to P. vivax malaria with variable eco-climatic and varying vivax malaria epidemiology across different regions, such a question could well be answered in Indians. For this, we have genotyped the FY gene at the -33(rd) and the 125(th) nucleotide positions in 250 Indians sampled from six different zonal plus one tribal population covering the whole of India and studied possible correlations with eco-climatic and vivax malaria incidences. No FY*O allele was found, however, both the FY*A and FY*B alleles forming FY*A/FY*A, FY*A/FY*B and FY*B/FY*B genotypes were widely distributed among Indians. Five out of seven population samples significantly deviated from the Hardy-Weinberg equilibrium expectation, and two alleles (FY*A and FY*B) and the homozygote genotype, FY*B/FY*B were clinically distributed over the population coordinates. Furthermore, vivax malaria incidences over the past five years were significantly negatively and positively associated with the frequencies of the FY*A and FY*B alleles, respectively. The Northern Indians were highly differentiated from the other zonal population samples at the FY gene, as evidenced from the reconstructed Neighbor-Joining phylogenetic tree. The results specify the role of natural selection in the distribution of FY gene polymorphism in India. Furthermore, the hypotheses on the part of the FY*A allele in conferring protection to vivax malaria could be validated following population genetic studies in a vivax malaria epidemiological setting, such as India.

FY*X real-time polymerase chain reaction with melting curve analysis associated with a complete one-step real-time FY genotyping.

PubMed

Ansart-Pirenne, H; Martin-Blanc, S; Le Pennec, P-Y; Rouger, P; Cartron, J-P; Tournamille, C

2007-02-01

The Duffy (FY) blood group system is controlled by four major alleles: FY*A and FY*B, the Caucasian common alleles, encoding Fy(a) and Fy(b) antigens; FY*X allele responsible for a poorly expressed Fy(b) antigen, and FY*Fy a silent predominant allele among Black population. Despite the recent development of a real-time fluorescent polymerase chain reaction (PCR) method for FY genotyping FY*X genotyping has not been described by this method. This study focused on the real-time FY*X genotyping development associated with a complete, one-step real-time FY genotyping, based on fluorescence resonance energy transfer (FRET) technology. Seventy-two blood samples from Fy(a+b-) Caucasian blood donors were studied by real-time PCR only. Forty-seven Caucasian and Black individual blood samples, referred to our laboratory, were studied by PCR-RFLP and real-time PCR. For each individual, the result of the genotype was compared to the known phenotype. The FY*X allele frequency calculated in an Fy(a+b-) Caucasian blood donors population was 0.014. With the Caucasian and Black patient samples we found a complete correlation between PCR-RFLP and the real-time PCR method whatever the alleles combination tested. When the known phenotype was not correlated to FY*X genotype, the presence of the Fy(b) antigen was always confirmed by adsorption-elution. The real-time technology method is rapid and accurate for FY genotyping. From now, we are able to detect the FY*X allele in all the alleles combinations studied. Regarding its significant frequency, the detection of the FY*X allele is useful for the correct typing of blood donors and recipients considering the therapeutic use of blood units and the preparation of test red blood cells for antibody screening.

FY*A silencing by the GATA-motif variant FY*A(-69C) in a Caucasian family.

PubMed

Písačka, Martin; Marinov, Iuri; Králová, Miroslava; Králová, Jana; Kořánová, Michaela; Bohoněk, Miloš; Sood, Chhavi; Ochoa-Garay, Gorka

2015-11-01

The c.1-67C variant polymorphism in a GATA motif of the FY promoter is known to result in erythroid-specific FY silencing, that is, in Fy(a-) and Fy(b-) phenotypes. A Caucasian donor presented with the very rare Fy(a-b-) phenotype and was further investigated. Genomic DNA was analyzed by sequencing to identify the cause of the Fy(a-b-) phenotype. Samples were collected from some of his relatives to establish a correlation between the serology and genotyping results. Red blood cells were analyzed by gel column agglutination and flow cytometry. Genomic DNA was analyzed on genotyping microarrays, by DNA sequencing and by allele-specific PCR. In the donor, a single-nucleotide polymorphism T>C within the GATA motif was found at Position c.1-69 of the FY promoter and shown to occur in the FY*A allele. His genotype was found to be FY*A(-69C), FY*BW.01. In six FY*A/FY*B heterozygous members of the family, a perfect correlation was found between the presence vs. absence of the FY*A(-69C) variant allele and a Fy(a-) vs. Fy(a+) phenotype. The location of the c.1-69C polymorphism in a GATA motif whose disruption is known to result in a Fy null phenotype, together with the perfect correlation between the presence of the FY*A(-69C) allele and the Fy(a-) phenotype support a cause-effect relationship between the two. © 2015 AABB.

Molecular identification of rare FY*Null and FY*X alleles in Caucasian thalassemic family from Sardinia.

PubMed

Manfroi, Silvia; Scarcello, Antonio; Pagliaro, Pasqualepaolo

2015-10-01

Molecular genetic studies on Duffy blood group antigens have identified mutations underlying rare FY*Null and FY*X alleles. FY*Null has a high frequency in Blacks, especially from sub-Saharan Africa, while its frequency is not defined in Caucasians. FY*X allele, associated with Fy(a-b+w) phenotype, has a frequency of 2-3.5% in Caucasian people while it is absent in Blacks. During the project of extensive blood group genotyping in patients affected by hemoglobinopathies, we identified FY*X/FY*Null and FY*A/FY*Null genotypes in a Caucasian thalassemic family from Sardinia. We speculate on the frequency of FY*X and FY*Null alleles in Caucasian and Black people; further, we focused on the association of FY*X allele with weak Fyb antigen expression on red blood cells and its identification performing high sensitivity serological typing methods or genotyping. Copyright © 2015 Elsevier Ltd. All rights reserved.

Control Design for an Advanced Geared Turbofan Engine

NASA Technical Reports Server (NTRS)

Chapman, Jeffryes W.; Litt, Jonathan S.

2017-01-01

This paper describes the design process for the control system of an advanced geared turbofan engine. This process is applied to a simulation that is representative of a 30,000 pound-force thrust class concept engine with two main spools, ultra-high bypass ratio, and a variable area fan nozzle. Control system requirements constrain the non-linear engine model as it operates throughout its flight envelope of sea level to 40,000 feet and from 0 to 0.8 Mach. The purpose of this paper is to review the engine control design process for an advanced turbofan engine configuration. The control architecture selected for this project was developed from literature and reflects a configuration that utilizes a proportional integral controller with sets of limiters that enable the engine to operate safely throughout its flight envelope. Simulation results show the overall system meets performance requirements without exceeding operational limits.

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

We conducted physics experiments: record normalized {Beta} = 4.9 achieved in VH-mode, {Beta} limits of ITER-like configurations evaluated, FWCD commissioning. The tokamak vessel was opened to atmosphere for six weeks and a number of key diagnostics for understanding the divertor were installed. The DIII-D Advisory Committee met in January to review the DIII-D program and plan. They commended us for recent progress and supported the vanadium divertor design. The U.S./Japan DIII-D steering committee met and recommended extending the agreement to the year 2000. The field work proposal for FY 96/97 was presented in Washington on March 29, 1995. A reviewmore » of the DIII-D plan to install vanadium structural components as part of the new radiative divertor modification was held in Washington 31, 1995 and the panel endorsed the plans. Preliminary plans were developed with PPPL for collaborations in FY96,« less

Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

PubMed Central

Germi, Raphaëlle; Bernard, Corinne; Garcia-Montojo, Marta; Deluen, Cécile; Farinelli, Laurent; Faucard, Raphaël; Veas, Francisco; Stefas, Ilias; Fabriek, Babs O; Van-Horssen, Jack; Van-der-Valk, Paul; Gerdil, Claire; Mancuso, Roberta; Saresella, Marina; Clerici, Mario; Marcel, Sébastien; Creange, Alain; Cavaretta, Rosella; Caputo, Domenico; Arru, Giannina; Morand, Patrice; Lang, Alois B; Sotgiu, Stefano; Ruprecht, Klemens; Rieckmann, Peter; Villoslada, Pablo; Chofflon, Michel; Boucraut, Jose; Pelletier, Jean; Hartung, Hans-Peter

2012-01-01

Background: The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family ‘W’ (HERV-W), induces dysimmunity and inflammation. Objective: The objective of this study was to confirm and specify the association between HERV-W/MSRV envelope (Env) expression and MS. Methods: 103 MS, 199 healthy controls (HC) and controls with other neurological diseases (28), chronic infections (30) or autoimmunity (30) were analysed with an immunoassay detecting Env in serum. Env RNA or DNA copy numbers in peripheral blood mononuclear cells (PBMC) were determined by a quantitative polymerase chain reaction (PCR). Env was detected by immunohistology in the brains of patients with MS with three specific monoclonals. Results: Env antigen was detected in a serum of 73% of patients with MS with similar prevalence in all clinical forms, and not in chronic infection, systemic lupus, most other neurological diseases and healthy donors (p<0.01). Cases with chronic inflammatory demyelinating polyneuropathy (5/8) and rare HC (4/103) were positive. RNA expression in PBMC and DNA copy numbers were significantly elevated in patients with MS versus HC (p<0.001). In patients with MS, DNA copy numbers were significantly increased in chronic progressive MS (secondary progressive MS vs relapsing–remitting MS (RRMS) p<0.001; primary progressive MS vs RRMS –<0.02). Env protein was evidenced in macrophages within MS brain lesions with particular concentrations around vascular elements. Conclusion: The association between MS disease and the MSRV-type HERV-W element now appears quite strong, as evidenced ex-vivo from serum and PBMC with post-mortem confirmation in brain lesions. Chronic progressive MS, RRMS and clinically isolated syndrome show different ELISA (Enzyme-Linked Immunosorbent Assay) and/or PCR profiles suggestive of an increase with disease evolution, and amplicon sequencing confirms the association with particular HERV-W elements. PMID:22457345

NUCLEAR ENVELOPE-ASSOCIATED RESUMPTION OF RNA SYNTHESIS IN LATE MITOSIS OF HELA CELLS

PubMed Central

Simmons, T.; Heywood, P.; Hodge, L.

1973-01-01

The restitution of RNA synthesis in cultures progressing from metaphase into interphase (G1) has been investigated in synchronized HeLa S3 cells by using inhibitors of macro-molecular synthesis and the technique of electron microscope autoradiography. The rate of incorporation of radioactive uridine into RNA approached interphase levels in the absence of renewed protein synthesis. In contrast, maintenance of this rate in G1 was dependent upon renewed protein synthesis. Restoration of synthesis of heterogeneous nuclear RNA occurred under conditions that inhibited production of ribosomal precursor RNA. In autoradiographs of individual cells exposed to radioactive uridine, silver grains were first detected after nuclear envelope reformation at the periphery of the chromosome mass but before chromosomal decondensation. These data are consistent with the following interpretation. Multiple RNA polymerase activities persist through mitosis and are involved in the initiation of RNA synthesis in early telophase at sites on the nuclear envelope. PMID:4752403

Marine Animal Alert System -- Task 2.1.5.3: Development of Monitoring Technologies -- FY 2011 Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carlson, Thomas J.; Deng, Zhiqun; Myers, Joshua R.

2011-09-30

The Marine Animal Alert System (MAAS) in development by the Pacific Northwest National Laboratory is focused on providing elements of compliance monitoring to support deployment of marine hydrokinetic energy devices. An initial focus is prototype tidal turbines to be deployed in Puget Sound in Washington State. The MAAS will help manage the risk of injury or mortality to marine animals from blade strike or contact with tidal turbines. In particular, development has focused on detection, classification, and localization of listed Southern Resident killer whales within 200 m of prototype turbines using both active and passive acoustic approaches. At the closemore » of FY 2011, a passive acoustic system consisting of a pair of four-element star arrays and parallel processing of eight channels of acoustic receptions has been designed and built. Field tests of the prototype system are scheduled for the fourth quarter of calendar year 2011. Field deployment and testing of the passive acoustic prototype is scheduled for the first quarter of FY 2012. The design of an active acoustic system that could be built using commercially available off-the-shelf components from active acoustic system vendors is also in the final stages of design and specification.« less

A novel FY*A allele with the 265T and 298A SNPs formerly associated exclusively with the FY*B allele and weak Fy(b) antigen expression: implication for genotyping interpretative algorithms.

PubMed

Lopez, G H; Condon, J A; Wilson, B; Martin, J R; Liew, Y-W; Flower, R L; Hyland, C A

2015-01-01

An Australian Caucasian blood donor consistently presented a serology profile for the Duffy blood group as Fy(a+b+) with Fy(a) antigen expression weaker than other examples of Fy(a+b+) red cells. Molecular typing studies were performed to investigate the reason for the observed serology profile. Blood group genotyping was performed using a commercial SNP microarray platform. Sanger sequencing was performed using primer sets to amplify across exons 1 and 2 of the FY gene and using allele-specific primers. The propositus was genotyped as FY*A/B, FY*X heterozygote that predicted the Fy(a+b+(w) ) phenotype. Sequencing identified the 265T and 298A variants on the FY*A allele. This link between FY*A allele and 265T was confirmed by allele-specific PCR. The reduced Fy(a) antigen reactivity is attributed to a FY*A allele-carrying 265T and 298A variants previously defined in combination only with the FY*B allele and associated with weak Fy(b) antigen expression. This novel allele should be considered in genotyping interpretative algorithms for generating a predicted phenotype. © 2014 International Society of Blood Transfusion.

Letterman Army Institute of Research Annual Research Progress Report, FY 1981.

DTIC Science & Technology

1981-10-01

with physiology and mech- anisms of skin damage and repair. The mechanisms by which nerve agents and vesicants produce physiologic aberration and...enzyme vital for nerve function. Organophos- phates react rapidly and covalently with the enzyme to produce an in- active enzyme. Reactivation of the...warfare agents . These organic molecules may also alter the natural defense mechanism by activating or deactivating enzymes in the skin that destroy

Research and Technology Operating Plan Summary, Fiscal Year 1972 Research and Technology Program

NASA Technical Reports Server (NTRS)

1971-01-01

The NASA Research and Technology program for FY 1972 is presented. It is a compilation of the summary portions of each of the RTOPs (Research and Technology Operating Plan) used for management review and control of research currently in progress throughout NASA. The RTOP Summary is designed to facilitate communication and coordination among concerned technical personnel in government, in industry, and in universities.

FY2010 Annual Progress Report for Propulsion Materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, Patrick B.; Schutte, Carol L.; Gibbs, Jerry L.

The Propulsion Materials Technology actively supports the energy security and reduction of greenhouse emissions goals of the Vehicle Technologies Program by developing advanced materials that enable development of higher efficiency powertrains for ground transportation. Propulsion Materials works closely with the other disciplines within the VT Program to identify the materials properties essential for the development of cost-effective, highly efficient, and environmentally friendly next-generation heavy and light duty powertrains.

The Blueprint for a Secure Energy Future: Progress Report

DTIC Science & Technology

2012-03-01

Over the past three years, the Administration has continued to develop and expand America’s high-speed and intercity passenger rail system. In May...2011, DOT announced $2 billion in high-speed rail, bringing our unprecedented investment to $10.1 billion to date. In FY 2011, intercity rail...thousands of jobs, improve and expand travel options, cut energy use and help make our communities more livable. Improving Transportation Choices

FY2010 Annual Progress Report for Energy Storage Research and Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2011-01-28

The energy storage research and development effort within the VT Program is responsible for researching and improving advanced batteries and ultracapacitors for a wide range of vehicle applications, including HEVs, PHEVs, EVs, and fuel cell vehicles (FCVs). Over the past few years, the emphasis of these efforts has shifted from high-power batteries for HEV applications to high-energy batteries for PHEV and EV applications.

US Army Institute of Dental Research Annual Progress Report FY80.

DTIC Science & Technology

1980-10-01

indicates that use of the laser technique does result in increased connectiv tissue regeneration and improved resolution of the periodontal defects...connectiv tissue regeneration and improved resolution of the periodontal defects. Final analysis of histologic data on the use of the neodymium laser for in...and 21 Bone Regeneration in Trnumatic Wounds (Pathology) DA OH 6038 Development of Endodontic Procedures for 22 Military Dentistry ( Oral Biology) DA OK

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singer, M.; Daley, R.

This report focuses on the National Renewable Energy Laboratory's (NREL) fiscal year (FY) 2012 effort that used the NREL Optimal Vehicle Acquisition (NOVA) analysis to identify optimal vehicle acquisition recommendations for eleven diverse federal agencies. Results of the study show that by following a vehicle acquisition plan that maximizes the reduction in greenhouse gas (GHG) emissions, significant progress is also made toward the mandated complementary goals of acquiring alternative fuel vehicles, petroleum use reduction, and alternative fuel use increase.

Population Representation in the Military Services: Fiscal Year 2002

DTIC Science & Technology

2004-03-01

a more streamlined force. Although much progress has been achieved with regard to gender equity, much work remains . The representation of women has...primary reason for the difference by gender is lower retention rates among enlisted women . 4-1 Chapter 4 ACTIVE COMPONENT OFFICERS The...for women . The occupational differences by gender are illustrated in Table 3.8. In FY 2002, almost half of enlisted women were in functional

United States Air Force Statistical Digest, Fiscal Year 1960. Fifteenth Edition

DTIC Science & Technology

1960-09-30

USAF CIVILIAN EMPLOYEES IN SALARIED AND WAGE BOARD GROUPS EMPLOYED UNDER MILITARY , ASSISTANCE PROGRAM (MAP), AT END OF QUARTER - FY � (Previous year...provide summary data on all aspects of the Mlli_ 165 tary Assistance program administered by the Air Force. The data were compiled from progress reports...Military Assistance . MAP AIRCRAFT - Aircraft in foreign countries provided by the USAF under Military Assistance Program . AIRCRAFT ATTRITION - Aircraft

Military Manpower Training Report for FY 1979.

DTIC Science & Technology

1978-03-01

intermediate, and senior. Ed..cation in the military school system is fundamental to trw development of military officers who are fully qualified to perforr...of training inputs and loads, the Services are able to adapt the training system to changing conditions. However, it should be clear that extended...each Service maintains a system of professional military education which is progressive in nature. This education is related more to the increasing

Natural Selection Mediated Association of the Duffy (FY) Gene Polymorphisms with Plasmodium vivax Malaria in India

PubMed Central

Chittoria, Anita; Mohanty, Sujata; Jaiswal, Yogesh Kumar; Das, Aparup

2012-01-01

The Duffy (Fy) antigens act as receptors for chemokines as well as for Plasmodium vivax to invade human RBCs. A recent study has correlated the occurrence of the FY*A allele of Duffy gene with decreased susceptibility to vivax malaria, but no epidemiological correlation between the distribution of FY*A allele and incidences of vivax malaria has been established so far. Furthermore, if such correlations exist, whether natural selection has mediated the association, is an important question. Since India is highly endemic to P. vivax malaria with variable eco-climatic and varying vivax malaria epidemiology across different regions, such a question could well be answered in Indians. For this, we have genotyped the FY gene at the −33rd and the 125th nucleotide positions in 250 Indians sampled from six different zonal plus one tribal population covering the whole of India and studied possible correlations with eco-climatic and vivax malaria incidences. No FY*O allele was found, however, both the FY*A and FY*B alleles forming FY*A/FY*A, FY*A/FY*B and FY*B/FY*B genotypes were widely distributed among Indians. Five out of seven population samples significantly deviated from the Hardy-Weinberg equilibrium expectation, and two alleles (FY*A and FY*B) and the homozygote genotype, FY*B/FY*B were clinally distributed over the population coordinates. Furthermore, vivax malaria incidences over the past five years were significantly negatively and positively associated with the frequencies of the FY*A and FY*B alleles, respectively. The Northern Indians were highly differentiated from the other zonal population samples at the FY gene, as evidenced from the reconstructed Neighbor-Joining phylogenetic tree. The results specify the role of natural selection in the distribution of FY gene polymorphism in India. Furthermore, the hypotheses on the part of the FY*A allele in conferring protection to vivax malaria could be validated following population genetic studies in a vivax malaria epidemiological setting, such as India. PMID:23028857

LLE Review 116 (July-September 2008)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marozas, J.A., editor

2010-03-12

This issue has the following articles: (1) Optimizing Electron-Positron Pair Production on kJ-Class High-Intensity Lasers for the Purpose of Pair-Plasma Creation; (2) Neutron Yield Study of Direct-Drive, Low-Adiabat Cryogenic D2 Implosions on OMEGA; (3) Al 1s-2p Absorption Spectroscopy of Shock-Wave Heating and Compression in Laser-Driven Planar Foil; (4) A Measurable Lawson Criterion and Hydro-Equivalent Curves for Inertial Confinement Fusion; (5) Pulsed-THz Characterization of Hg-Based, High-Temperature Superconductors; (6) LLE's Summer High School Research Program; (7) FY08 Laser Facility Report; and (8) National Laser Users Facility and External Users Programs.

Simulators Sustainment Management: Advance Planning Briefing to Industry

DTIC Science & Technology

2007-05-15

ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12 . DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13...Training Systems  Business  Opportunities  FY07­08  T­1A Ground Based Training System CLS Re­compete  C­130 Landing Gear Trainer  MC­130W Weapon...value $150M • Full and open competition  • One  year  basic with nine option  years   Name:  Capt. Greg Purnell  Organization:  507 ACSS/GFLA  Phone

Aerodynamic Characteristics at High Speeds of Full-Scale Propellers having Different Shank Designs

NASA Technical Reports Server (NTRS)

Maynard, Julian D.

1947-01-01

Tests of two 10-foot-diameter two-blade propellers which differed only in shank design have been made in the Langley 16-foot high-speed tunnel. The propellers are designated by their blade design numbers, NACA 10-(5)(08)-03, which had aerodynamically efficient airfoil shank sections, and NACA l0-(5)(08)-03R which had thick cylindrical shank sections typical of conventiona1 blades, The propellers mere tested on a 2000-horsepower dynamometer through a range of blade-angles from 20deg to 55deg at various rotational speeds and at airspeeds up to 496 miles per hour. The resultant tip speeds obtained simulate actual flight conditions, and the variation of air-stream Mach number with advance ratio is within the range of full-scale constant-speed propeller operation. Both propellers were very efficient, the maximum envelope efficiency being approximately 0,95 for the NACA 10-(5)(08)-03 propeller and about 5 percent less for the NACA 10-(5)(08)-03R propeller. Based on constant power and rotational speed, the efficiency of the NACA 10-(05)(08)-03 propeller was from 2.8 to 12 percent higher than that of the NACA 10-(5)(08)-03R propeller over a range of airspeeds from 225 to 450 miles per hour. The loss in maximum efficiency at the design blade angle for the NACA 10-(5)(08)-03 and 10-(5)(08)-03R propellers vas about 22 and 25 percent, respectively, for an increase in helical tip Mach number from 0.70 to 1.14.

Effects of Electromagnetic Fields on Fish and Invertebrates: Task 2.1.3: Effects on Aquatic Organisms - Fiscal Year 2011 Progress Report - Environmental Effects of Marine and Hydrokinetic Energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woodruff, Dana L.; Schultz, Irvin R.; Marshall, Kathryn E.

This fiscal year (FY) 2011 progress report (Task 2.1.3 Effects on Aquatic Organisms, Subtask 2.3.1.1 Electromagnetic Fields) describes studies conducted by PNNL as part of the DOE Wind and Water Power Program to examine the potential effects of electromagnetic fields (EMF) from marine and hydrokinetic devices on aquatic organisms, including freshwater and marine fish and marine invertebrates. In this report, we provide a description of the methods and results of experiments conducted in FY 2010-FY 2011 to evaluate potential responses of selected aquatic organisms. Preliminary EMF laboratory experiments during FY 2010 and 2011 entailed exposures with representative fish and invertebratemore » species including juvenile coho salmon (Oncorhynchus kisutch), Atlantic halibut (Hippoglossus hippoglossus), California halibut (Paralicthys californicus), rainbow trout (Oncorhynchus mykiss), and Dungeness crab (Metacarcinus magister). These species were selected for their ecological, commercial, and/or recreational importance, as well as their potential to encounter an MHK device or transmission cable during part or all of their life cycle. Based on previous studies, acute effects such as mortality were not expected to occur from EMF exposures. Therefore, our measurement endpoints focused on behavioral responses (e.g., detection of EMF, interference with feeding behavior, avoidance or attraction to EMF), developmental changes (i.e., growth and survival from egg or larval stage to juvenile), and exposure markers indicative of physiological responses to stress. EMF intensities during the various tests ranged from 0.1 to 3 millitesla, representing a range of upper bounding conditions reported in the literature. Experiments to date have shown there is little evidence to indicate distinct or extreme behavioral responses in the presence of elevated EMF for the species tested. Several developmental and physiological responses were observed in the fish exposures, although most were not statistically significant. Additional species are currently planned for laboratory testing in the next fiscal year (e.g. an elasmobranch, American lobster) to provide a broader assessment of species important to stakeholders. The collective responses of all species will be assessed in terms of life stage, exposure scenarios, and biological relevance, to address current uncertainties related to effects of EMF on aquatic organisms.« less

Molecular basis of the Duffy blood group system.

PubMed

Höher, Gabriela; Fiegenbaum, Marilu; Almeida, Silvana

2018-01-01

ACKR1, located on chromosome 1q23.2, is the gene that encodes a glycoprotein expressing the Duffy blood group antigens. This gene is transcribed in two mRNA variants yielding two isoforms, encoding proteins with 338 and 336 amino acids. This review provides a general overview of the Duffy blood group to characterise and elucidate the genetic basis of this system. The Fy a and Fy b antigens are encoded by co-dominant FY*A (FY*01) and FY*B (FY*02) alleles, which differ by c.125G>A (rs12075), defining the Fy(a+b-), Fy(a-b+) and Fy(a+b+) phenotypes. The Fy(a-b-) phenotype that occurs in Africans provides an explanation for the apparent absence of Plasmodium vivax in this region: this phenotype arises from homozygosity for the FY*B allele carrying a point mutation c.1-67T>C (rs2814778), which prevents Fy b antigen expression only in red blood cells. The same mutation has also been found on the FY*A allele, but it is very rare. The Fy(a-b-) phenotype in Europeans and Asians arises from mutations in the coding region of the FY*A or FY*B allele, preventing Duffy antigen expression on any cell in the body and thus are true Duffy null phenotypes. According to the International Society for Blood Transfusion, ten alleles are associated with the null expression of the Fy antigens. Furthermore, different allelic forms of FY*B modify Fy b antigen expression, which may result in very weak or equivocal serology results. The mostly common found variants, c.265C>T (rs34599082) and c.298G>A (rs13962) -previously defined in combination only with the FY*B allele - have already been observed in the FY*A allele. Thus, six alleles have been recognised and associated with weak expression of the Fy antigens. Considering the importance of the Duffy blood group system in clinical medicine, additional studies via molecular biology approaches must be performed to resolve and clarify the discrepant results that are present in the erythrocyte phenotyping.

Advanced MHD Algorithm for Solar and Space Science: lst Year Semi Annual Progress Report

NASA Technical Reports Server (NTRS)

Schnack, Dalton D.; Lionello, Roberto

2003-01-01

We report progress for the development of MH4D for the first and second quarters of FY2004, December 29, 2002 - June 6, 2003. The present version of MH4D can now solve the full viscous and resistive MHD equations using either an explicit or a semi-implicit time advancement algorithm. In this report we describe progress in the following areas. During the two last quarters we have presented poster at the EGS-AGU-EUG Joint Assembly in Nice, France, April 6-11, 2003, and a poster at the 2003 International Sherwood Theory Conference in Corpus Christi, Texas, April 28-30 2003. In the area of code development, we have implemented the MHD equations and the semi-implicit algorithm. The new features have been tested.

2001 Industry Studies: Munitions

DTIC Science & Technology

2001-01-01

Lt Col Michael P. Howe, USAF Lt Col William E . MacLure, USAF Mr. Terrence K. May, Dept of the Air Force LTC Paul M. McQuain, USA CDR David L. Prater...USN CAPT Steven K. Tucker, USN Lt Col Richard L. Wojick , Jr., USAF Mr. Michael J. Yurina, Dept of the Navy Dr. Thomas C. Hone, faculty CAPT Ralph...FY98 FY99 FY00 FY01 FY02 FY03 FY04 FY05 FY 00 $ BI LL IO N RDT& E - S&T (Far-Term) RDT& E - Development (Near- and Mid-Term) Procurement (Near-Term) 6 As

The Role of Central Metabolism in Prostate Cancer Progression

DTIC Science & Technology

2012-07-01

AD_________________ Award Number: W81XWH-08-1-0694 TITLE: The Role of Central Metabolism in Prostate...SUBTITLE The Role of Central Metabolism in Prostate Cancer Progression 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-08-1-0694 5c. PROGRAM...examine the excised prostate tissue for differences in tumor growth, proteomes and intermediates in polyunsaturated fatty acid (PUFA) metabolism . The

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zheng, Liange; Li, Lianchong; Rutqvist, Jonny

Clay/shale has been considered as potential host rock for geological disposal of high-level nuclear waste throughout the world, because of its low permeability, low diffusion coefficient, high retention capacity for radionuclides, and capability to self-seal fractures induced by tunnel excavation. For example, Callovo-Oxfordian argillites at the Bure site, France (Fouche et al., 2004), Toarcian argillites at the Tournemire site, France (Patriarche et al., 2004), Opalinus Clay at the Mont Terri site, Switzerland (Meier et al., 2000), and Boom clay at the Mol site, Belgium (Barnichon and Volckaert, 2003) have all been under intensive scientific investigation (at both field and laboratorymore » scales) for understanding a variety of rock properties and their relationships to flow and transport processes associated with geological disposal of nuclear waste. Clay/shale formations may be generally classified as indurated or plastic clays (Tsang and Hudson, 2010). The latter (including Boom clay) is a softer material without high cohesion; its deformation is dominantly plastic. During the lifespan of a clay repository, the repository performance is affected by complex thermal, hydrogeological, mechanical, chemical (THMC) processes, such as heat release due to radionuclide decay, multiphase flow, formation of damage zones, radionuclide transport, waste dissolution, and chemical reactions. All these processes are related to each other. An in-depth understanding of these coupled processes is critical for the performance assessment (PA) of the repository. These coupled processes may affect radionuclide transport by changing transport paths (e.g., formation and evolution of excavation damaged zone (EDZ)) and altering flow, mineral, and mechanical properties that are related to radionuclide transport. While radionuclide transport in clay formation has been studied using laboratory tests (e,g, Appelo et al. 2010, Garcia-Gutierrez et al., 2008, Maes et al., 2008), short-term field tests (e.g. Garcia-Gutierrez et al. 2006, Soler et al. 2008, van Loon et al. 2004, Wu et al. 2009) and numerical modeling (de Windt et al. 2003; 2006), the effects of THMC processes on radionuclide transport are not fully investigated. The objectives of the research activity documented in this report are to improve a modeling capability for coupled THMC processes and to use it to evaluate the THMC impacts on radionuclide transport. This research activity addresses several key Features, Events and Processes (FEPs), including FEP 2.2.08, Hydrologic Processes, FEP 2.2.07, Mechanical Processes and FEP 2.2.09, Chemical Process— Transport, by studying near-field coupled THMC processes in clay/shale repositories and their impacts on radionuclide transport. This report documents the progress that has been made in FY12. Section 2 discusses the development of THMC modeling capability. Section 3 reports modeling results of THMC impacts on radionuclide transport. Planned work for the remaining months of FY12 and proposed work for FY13 are presented in Section 4.« less

FY polymorphisms and vivax malaria in inhabitants of Amazonas State, Brazil.

PubMed

Albuquerque, Sérgio Roberto Lopes; Cavalcante, Francimary de Oliveira; Sanguino, Edalton Cesar; Tezza, Lucianna; Chacon, Fernanda; Castilho, Lilian; dos Santos, Maria Cristina

2010-04-01

Although the importance of glycoprotein Duffy in the human red cells invasion process by Plasmodium vivax merozoites has been demonstrated, little is known about the associations of FY polymorphisms with malaria vivax parasitic density. In this study, we investigated the associations of the SNPs 125 G>A, 265 C>T, and 298 G>A on FY gene and the SNP -33T>C on GATA box with the vivax malaria parasitic density in inhabitants of Amazon State, Brazil. Verifications of P. vivax, as well as the definition of parasitism, were determined by standard screening tests in 497 patients. FY phenotyping was performed in all samples by hemagglutination using gel cards. Molecular analysis for FY/GATA polymorphisms were performed by polymerase chain reaction-restriction fragment length polymorphism. Our data showed that in this population, FY*A/FY*B-33 and FY*B/FY*B-33 genotypes may be a selective advantage, reducing the frequency of P. vivax infection in the studied area. FY*A/FY*B and FY*A/FY*A genotypes showed to be associated with the rise of the frequency of P. vivax infection, and FY*B/FY*X and FY*A/FY*X showed to be associated with the low levels of parasitism. These results suggest that natural adaptations, in malaria-endemic regions, could be leading to the arising of partial defense mechanisms against P. vivax, which is different from the previously described in African descents, as well as adaptations that could be increasing the susceptibility of human to this kind of malaria.

FY 2017 Stockpile Stewardship and Management Plan - Biennial Plan Summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

2016-03-01

This year’s summary report updates the Fiscal Year 2016 Stockpile Stewardship and Management Plan (FY 2016 SSMP), the 25-year strategic program of record that captures the plans developed across numerous NNSA programs and organizations to maintain and modernize the scientific tools, capabilities, and infrastructure necessary to ensure the success of NNSA’s nuclear weapons mission. The SSMP is a companion to the Prevent, Counter, and Respond: A Strategic Plan to Reduce Global Nuclear Threats (FY 2017-2021) report, the planning document for NNSA’s nuclear threat reduction mission. New versions of both reports are published each year in response to new requirements andmore » challenges. Much was accomplished in FY 2015 as part of the program of record described in this year’s SSMP. The science-based Stockpile Stewardship Program allowed the Secretaries of Energy and Defense to certify for the twentieth time that the stockpile remains safe, secure, and effective without the need for underground nuclear explosive testing. The talented scientists, engineers, and technicians at the three national security laboratories, the four nuclear weapons production plants, and the national security site are primarily responsible for this continued success. Research, development, test, and evaluation programs have advanced NNSA’s understanding of weapons physics, component aging, and material properties through first-of-a-kind shock physics experiments, along with numerous other critical experiments conducted throughout the nuclear security enterprise. The multiple life extension programs (LEPs) that are under way made progress toward their first production unit dates. The W76-1 LEP is past the halfway point in total production, and the B61-12 completed three development flight tests. Critical to this success is the budget. The Administration’s budget request for NNSA’s Weapons Activities has increased for all but one of the past seven years, resulting in a total increase of approximately 45 percent since 2010. If adopted by Congress, the FY 2017 budget request will increase funding by $396 million (about 4.5 percent) from the enacted FY 2016 level. A significant portion of the increase would fund the research for multiple life extension programs, support the programs in Directed Stockpile Work, and modernize the physical infrastructure of the nuclear security enterprise.« less

Associations of HLA DRB1 alleles with IgG oligoclonal bands and their influence on multiple sclerosis course and disability status.

PubMed

Balnytė, Renata; Rastenytė, Daiva; Vaitkus, Antanas; Skrodenienė, Erika; Vitkauskienė, Astra; Ulozienė, Ingrida

2016-01-01

Oligoclonal bands (OCB) may be associated with the genes of HLA complex, which allows to consider the possible interaction of genetic and immunological factors and its importance in the development and progression of multiple sclerosis (MS). The aim of this study was to evaluate the associations between HLA DRB1 alleles and oligoclonal bands (OCBs) in the disease course and disability of multiple sclerosis (MS) patients. This was a prospective study of 120 patients with MS. HLA DRB1 alleles were genotyped using the polymerase chain reaction. Matched cerebrospinal fluid (CSF) and plasma samples were analyzed using isoelectric focusing and IgG specific immunofixation to test for the presence of intrathecal specific OCB. HLA DRB1*08 allele was related to a lower degree of disability. Oligoclonal bands were an independent and significant factor that influenced disability status irrespective of HLA DRB1* 04, *07, *08, *13, *15 and *16 alleles. Age at the onset and duration of the disease were independent and significant factors for MS progression in all logistic regression models with each newly added HLA DRB1 allele. HLA DRB1*08 allele was related to 75% lower odds that relapsing remitting (RR) MS will change to a progressive course MS irrespective of the other factors investigated. Detection of OCBs in the CSF was associated with the higher possibility of RR MS progression in all cases, except when the *08 allele was present. OCBs had an influence on disability status, while HLA DRB1*08 allele was significantly associated with lower possibility that RR MS will change to progressive course MS. Copyright © 2016 The Lithuanian University of Health Sciences. Production and hosting by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

42 CFR 495.104 - Incentive payments to eligible hospitals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... first payment year is FY 2011 may receive such payments for FYs 2011 through 2014. (2) Hospitals whose... first payment year is FY 2014 may receive such payments for FY 2014 through 2016. (5) Hospitals whose... 2011— (A) 1 for FY 2011; (B)3/4 for FY 2012; (C)1/2 for FY 2013; and (D)1/4 for FY 2014. (ii) For...

KSC-08pd0729

NASA Image and Video Library

2008-03-11

KENNEDY SPACE CENTER, FLA. -- Clouds of smoke and steam seem to envelop space shuttle Atlantis as it leaps into the night sky from Launch Pad 39A at NASA's Kennedy Space Center on the STS-123 mission. Liftoff was on time at 2:28 a.m. EDT. Endeavour's crew will make a record-breaking 16-day mission to the International Space Station and deliver the first section of the Japan Aerospace Exploration Agency's Kibo laboratory and the Canadian Space Agency's two-armed robotic system, Dextre. Photo courtesy of Scott Andrews

The x-ray luminosity-redshift relationship of quasars

PubMed Central

Segal, I. E.; Segal, W.

1980-01-01

Chronometric cosmology provides an excellent fit for the phenomenological x-ray luminosity-redshift relationship for 49 quasars observed by the Einstein satellite. Analysis of the data on the basis of the Friedmann cosmology leads to a correlation of absolute x-ray luminosity with redshift of >0.8, which is increased to ∼1 in the bright envelope. Although the trend might be ascribed a priori to an observational magnitude bias, it persists after nonparametric, maximum-likelihood removal of this bias. PMID:16592826

Biochemical Requirements of Virus Wrapping by the Endoplasmic Reticulum: Involvement of ATP and Endoplasmic Reticulum Calcium Store during Envelopment of African Swine Fever Virus

PubMed Central

Cobbold, Christian; Brookes, Sharon M.; Wileman, Thomas

2000-01-01

Enwrapment by membrane cisternae has emerged recently as a mechanism of envelopment for large enveloped DNA viruses, such as herpesviruses, poxviruses, and African swine fever (ASF) virus. For both ASF virus and the poxviruses, wrapping is a multistage process initiated by the recruitment of capsid proteins onto membrane cisternae of the endoplasmic reticulum (ER) or associated ER-Golgi intermediate membrane compartments. Capsid assembly induces progressive bending of membrane cisternae into the characteristic shape of viral particles, and envelopment provides virions with two membranes in one step. We have used biochemical assays for ASF virus capsid recruitment, assembly, and envelopment to define the cellular processes important for the enwrapment of viruses by membrane cisternae. Capsid assembly on the ER membrane, and envelopment by ER cisternae, were inhibited when cells were depleted of ATP or depleted of calcium by incubation with A23187 and EDTA or the ER calcium ATPase inhibitor, thapsigargin. Electron microscopy analysis showed that cells depleted of calcium were unable to assemble icosahedral particles. Instead, assembly sites contained crescent-shaped and bulbous structures and, in rare cases, empty closed five-sided particles. Interestingly, recruitment of the capsid protein from the cytosol onto the ER membrane did not require ATP or an intact ER calcium store. The results show that following recruitment of the virus capsid protein onto the ER membrane, subsequent stages of capsid assembly and enwrapment are dependent on ATP and are regulated by the calcium gradients present across the ER membrane cisternae. PMID:10666244

[Application of melting curve to analyze genotype of Duffy blood group antigen Fy-a/b].

PubMed

Chen, Xue; Zhou, Chang-Hua; Hong, Ying; Gong, Tian-Xiang

2012-12-01

This study was aimed to establish the real-time multiple-PCR with melting curve analysis for Duffy blood group Fy-a/b genotyping. According to the sequence of mRNA coding for β-actin and Fy-a/b, the primers of β-actin and Fy-a/b were synthesized. The real-time multiple-PCR with melting curve analysis for Fy-a/b genotyping was established. The Fy-a/b genotyping of 198 blood donors in Chinese Chengdu area has been investigated by melting curve analysis and PCR-SSP. The results showed that the results of Fy-a/b genotype by melting curve analysis were consistent with PCR-SSP. In all of 198 donors in Chinese Chengdu, 178 were Fy(a) (+) (89.9%), 19 were Fy(a) (+) Fy(b) (+) (9.6%), and 1 was Fy(b) (+) (0.5%). The gene frequency of Fy(a) was 0.947, while that of Fy(b) was 0.053. It is concluded that the genotyping method of Duffy blood group with melting curve analysis is established, which can be used as a high-throughput screening tool for Duffy blood group genotyping; and the Fy(a) genotype is the major of Duffy blood group of donors in Chinese Chengdu area.

US Army Medical Bioengineering Research and Development Laboratory Annual Progress Report FY 85. Volume 2.

DTIC Science & Technology

1985-10-01

3E162777A878 HEALTH HAZARDS OF MILITARY MATERIEL 241 (U) Microbial Degradation and Yeast Bloassay 37 of Trichothecene Mycotoxins 63732A COMBAT MEDICAL MATERIEL...Combustion Products 283 (U) Literature Assessment of the Occupational 97 Health Effects of Selected Trichothecene Mycotoxins of Military Medical... mycotoxins in field water supplies treated with hypochlorite. 24. (U) The reaction products are to be separated by chromatographic procedures, and their

US Army Medical Bioengineering Research and Development Laboratory Annual Progress Report for FY 84. Volume 2

DTIC Science & Technology

1984-10-01

29 030 Bioassay for Mycotoxins in Water Using 29 Brine Shrimp Larvae ... .. ’ .- ,. ,. 031 Chemical Detection and Identification of 31 Trichothecene... Mycotoxins in Field Water Supplies 032 Microbial Degradation and Yeast Bioassay 33 of Trichothecene Mycotoxins DA Project 832 Combat Medical Materiel 35... mycotoxins in field water supplies treated with hypochlorite. 24. (U) The reaction products are to be separated by chromatographic procedures, and their

FY2015 Energy Storage R&D Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Energy Storage research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush.

Walter Reed Army Medical Center, Washington, D. C. Annual Progress Report FY-89. Volume 2. Part 2

DTIC Science & Technology

1990-01-02

Patterns of Cerebral Blood Flow Determined by Iodoamphetamine SPECT in Sjogren’s Syndrome and Systemic Lupus Erythematosus: A Pilot Study KEYWORDS: SPECT...scanning in patients with Sjogren’s Syndrome and SLE. To identify possible regional defects in cerebral blood flow and correlate these defects with the...in animals reveals myelosuppression, lymphoid atrophy, * hemorrhagic enterocolitis, renal tubular necrosis, and cochlear damage, as well as some

Defense: FY2014 Authorization and Appropriations

DTIC Science & Technology

2013-12-16

Remarks on the U.S;- India Defense Partnership at the Center for American Progress,” September 30, 2013, accessed at http://www.cq.com/doc...en bloc 1) Move $10 million to increase funding for research on prostate cancer agreed to voice vote Jackson Lee H.Amdt. 351 Move $500,000...to increase funding for PTSD treatment agreed to voice vote Jackson Lee H.Amdt. 354 Move $10 million to increase funding for research on breast

Force Projection Technology Overview

DTIC Science & Technology

2011-08-12

Technologies • Fuel Efficient Powertrain Lubricant • Nanotechnology for Fuels and Lubes • Water from Air • Water Reuse • In-line Water Monitoring...purification systems with new pretreatment, desalination and post treatment technologies. Payoff: • Reduces the logistical footprint associated with water...FY11 FY12 FY13 FY14 FY15 FY16 FY17 •Water From Air •Water Quality Monitoring •Water Reuse •Pre and Post Treatment • Desalination 6 5 5

75 FR 21314 - Medicaid Program; Final FY 2008, Revised Preliminary FY 2009, and Preliminary FY 2010...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-23

... Federal share) IMD and other mental health facility DSH expenditures applicable to the State's FY 1995 DSH... State's total computable DSH expenditures attributable to the FY 1995 DSH allotment for mental health... DSH expenditures (mental health facility plus inpatient hospital) applicable to the FY 1995 DSH...

[Clinical results of the aspheric intraocular lens FY-60AD (Hoya) with particular respect to decentration and tilt].

PubMed

Mester, U; Heinen, S; Kaymak, H

2010-09-01

Aspheric intraocular lenses (IOLs) aim to improve visual function and particularly contrast vision by neutralizing spherical aberration. One drawback of such IOLs is the enhanced sensitivity to decentration and tilt, which can deteriorate image quality. A total of 30 patients who received bilateral phacoemulsification before implantation of the aspheric lens FY-60AD (Hoya) were included in a prospective study. In 25 of the patients (50 eyes) the following parameters could be assessed 3 months after surgery: visual acuity, refraction, contrast sensitivity, pupil size, wavefront errors and decentration and tilt using a newly developed device. The functional results were very satisfying and comparable to results gained with other aspheric IOLs. The mean refraction was sph + 0.1 D (±0.7 D) and cyl 0.6 D (±0.8 D). The spherical equivalent was −0.2 D (±0.6 D). Wavefront measurements revealed a good compensation of the corneal spherical aberration but vertical and horizontal coma also showed opposing values in the cornea and IOL. The assessment of the lens position using the Purkinje meter demonstrated uncritical amounts of decentration and tilt. The mean amount of decentration was 0.2 mm±0.2 mm in the horizontal and vertical directions. The mean amount of tilt was 4.0±2.1° in horizontal and 3.0±2.5° in vertical directions. In a normal dioptric power range the aspheric IOL FY-60AD compensates the corneal spherical aberration very well with only minimal decentration. The slight tilt is symmetrical in both eyes and corresponds to the position of the crystalline lens in young eyes. This may contribute to our findings of compensated corneal coma.

78 FR 13743 - Department of State FY11 Service Contract Inventory

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... for FY12 and its analysis of the FY11 inventory. They are available here: http://csm.state.gov/content.asp?content_id=135&menu_id=71 . Section 743 of Division C of the FY 2010 Consolidated Appropriations... are being utilized in an appropriate manner. DATES: The FY12 inventory and FY11 analysis is available...

RESULTS OF THE FY09 ENHANCED DOE HIGH LEVEL WASTE MELTER THROUGHPUT STUDIES AT SRNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, F.; Edwards, T.

2010-06-23

High-level waste (HLW) throughput (i.e., the amount of waste processed per unit time) is a function of two critical parameters: waste loading (WL) and melt rate. For the Waste Treatment and Immobilization Plant (WTP) at the Hanford Site and the Defense Waste Processing Facility (DWPF) at the Savannah River Site (SRS), increasing HLW throughput would significantly reduce the overall mission life cycle costs for the Department of Energy (DOE). The objective of this task is to develop data, assess property models, and refine or develop the necessary models to support increased WL of HLW at SRS. It is a continuationmore » of the studies initiated in FY07, but is under the specific guidance of a Task Change Request (TCR)/Work Authorization received from DOE headquarters (Project Number RV071301). Using the data generated in FY07, FY08 and historical data, two test matrices (60 glasses total) were developed at the Savannah River National Laboratory (SRNL) in order to generate data in broader compositional regions. These glasses were fabricated and characterized using chemical composition analysis, X-ray Diffraction (XRD), viscosity, liquidus temperature (TL) measurement and durability as defined by the Product Consistency Test (PCT). The results of this study are summarized below: (1) In general, the current durability model predicts the durabilities of higher waste loading glasses quite well. A few of the glasses exhibited poorer durability than predicted. (2) Some of the glasses exhibited anomalous behavior with respect to durability (normalized leachate for boron (NL [B])). The quenched samples of FY09EM21-02, -07 and -21 contained no nepheline or other wasteform affecting crystals, but have unacceptable NL [B] values (> 10 g/L). The ccc sample of FY09EM21-07 has a NL [B] value that is more than one half the value of the quenched sample. These glasses also have lower concentrations of Al{sub 2}O{sub 3} and SiO{sub 2}. (3) Five of the ccc samples (EM-13, -14, -15, -29 and -30) completely crystallized with both magnetite and nepheline, and still had extremely low NL [B] values. These particular glasses have more CaO present than any of the other glasses in the matrix. It appears that while all of the glasses contain nepheline, the NL [B] values decrease as the CaO concentration increases from 2.3 wt% to 4.3 wt%. A different form of nepheline may be created at higher concentrations of CaO that does not significantly reduce glass durability. (4) The T{sub L} model appears to be under-predicting the measured values of higher waste loading glasses. Trends in T{sub L} with composition are not evident in the data from these studies. (5) A small number of glasses in the FY09 matrix have measured viscosities that are much lower than the viscosity range over which the current model was developed. The decrease in viscosity is due to a higher concentration of non-bridging oxygens (NBO). A high iron concentration is the cause of the increase in NBO. Durability, viscosity and T{sub L} data collected during FY07 and FY09 that specifically targeted higher waste loading glasses was compiled and assessed. It appears that additional data may be required to expand the coverage of the T{sub L} and viscosity models for higher waste loading glasses. In general, the compositional regions of the higher waste loading glasses are very different than those used to develop these models. On the other hand, the current durability model seems to be applicable to the new data. At this time, there is no evidence to modify this model; however additional experimental studies should be conducted to determine the cause of the anomalous durability data.« less

Duffy blood group phenotype-genotype correlations using high-resolution melting analysis PCR and microarray reveal complex cases including a new null FY*A allele: the role for sequencing in genotyping algorithms.

PubMed

Lopez, G H; Morrison, J; Condon, J A; Wilson, B; Martin, J R; Liew, Y-W; Flower, R L; Hyland, C A

2015-10-01

Duffy blood group phenotypes can be predicted by genotyping for single nucleotide polymorphisms (SNPs) responsible for the Fy(a) /Fy(b) polymorphism, for weak Fy(b) antigen, and for the red cell null Fy(a-b-) phenotype. This study correlates Duffy phenotype predictions with serotyping to assess the most reliable procedure for typing. Samples, n = 155 (135 donors and 20 patients), were genotyped by high-resolution melt PCR and by microarray. Samples were in three serology groups: 1) Duffy patterns expected n = 79, 2) weak and equivocal Fy(b) patterns n = 29 and 3) Fy(a-b-) n = 47 (one with anti-Fy3 antibody). Discrepancies were observed for five samples. For two, SNP genotyping predicted weak Fy(b) expression discrepant with Fy(b-) (Group 1 and 3). For three, SNP genotyping predicted Fy(a) , discrepant with Fy(a-b-) (Group 3). DNA sequencing identified silencing mutations in these FY*A alleles. One was a novel FY*A 719delG. One, the sample with the anti-Fy3, was homozygous for a 14-bp deletion (FY*01N.02); a true null. Both the high-resolution melting analysis and SNP microarray assays were concordant and showed genotyping, as well as phenotyping, is essential to ensure 100% accuracy for Duffy blood group assignments. Sequencing is important to resolve phenotype/genotype conflicts which here identified alleles, one novel, that carry silencing mutations. The risk of alloimmunisation may be dependent on this zygosity status. © 2015 International Society of Blood Transfusion.

Fy phenotype and gender determine plasma levels of monocyte chemotactic protein.

PubMed

Jilma-Stohlawetz, P; Homoncik, M; Drucker, C; Marsik, C; Rot, A; Mayr, W R; Seibold, B; Jilma, B

2001-03-01

In vitro studies indicate that the Fy blood group system antigens serve as receptors for chemokines such as monocyte chemotactic protein-1 (MCP-1) and RANTES. However, it is unclear whether subjects with the Fy(a-b-) phenotype exhibit altered clearance and hence altered plasma levels of chemo-kines, because they still express Fy on endothelial cells. To clarify a possible in vivo role of Fy on RBCs in the regulation of chemo-kine levels, healthy young volunteers of common Fy phenotypes were compared in a cross-sectional study. More than 90 percent of the 34 subjects of African origin were Fy(a-b-), one black volunteer was Fy(a+b-), and two were Fy(a-b+). As expected, all 65 white volunteers were positive for either Fy(a) and/or Fy(b). Unexpectedly, persons expressing either Fy(a) and/or Fy(b) had significantly higher plasma levels of MCP-1 than Fy(a-b-) volunteers (women: 154 vs. 110 ng/L, p<0.01; men: 179 vs. 169 ng/L, p = 0.03). Surprisingly, plasma levels of MCP-1 were found to be sex-dependent: median MCP-1 levels averaged 180 ng per L in men but only 139 ng per L in women (p<0.001). Further, MCP-1 levels decreased significantly throughout the menstrual cycle of 18 women studied longitudinally. MCP-1 levels are about 30 percent higher in men than in premenopausal women, and MCP-1 levels are also higher in persons with RBCs expressing Fy antigens than in Fy(a-b-) persons. These findings have direct implications for the concept and interpretation of clinical studies measuring MCP-1 levels; the role of the observed differences in MCP-1 levels for the pathogenesis of MCP-1-dependent diseases, such as atherosclerosis, merits further investigation.

Office of the Chief Financial Officer 2012 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, Kim

2013-01-31

Fiscal Year 2012 was a year of progress and change in the Office of the Chief Financial Officer (OCFO) organization. The notable accomplishments outlined below strengthened the quality of the OCFO’s stewardship and services in support of the scientific mission of Lawrence Berkeley National Laboratory (LBNL). Three strategies were key to this progress: organizational transformation aligned with our goals; process redesign and effective use of technology to improve efficiency, and innovative solutions to meet new challenges. Over the next year we will continue to apply these strategies to further enhance our contributions to the Lab’s scientific mission. What follows ismore » the budget, funding and costs for the office for FY 2012.« less

FY2017 Technology Integration Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The 2017 Technology Integration Annual Progress Report covers 27 multi-year projects funded by the Vehicle Technologies Office. The report includes information on 20 competitively awarded projects, ranging from training on alternative fuels and vehicles for first responders, to safety training and design for maintenance facilities housing gaseous fuel vehicles, to electric vehicle community partner programs. It also includes seven projects conducted by several of VTO’s national laboratory partners, Argonne National Laboratory, Oak Ridge National Laboratory and the National Renewable Energy Laboratory. These projects range from a Technical Assistance project for business, industry, government and individuals, to the EcoCar 3 Studentmore » Competition, and the Fuel Economy Information Project.« less

FY2016 Advanced Batteries R&D Annual Progress Report - Part 4 of 5

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Advanced Batteries research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Battery subprogram in 2016. This section covers Advanced Battery Materials Research (BMR)more » part 1.« less

FY2016 Advanced Batteries R&D Annual Progress Report - Part 3 of 5

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Advanced Batteries research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Battery subprogram in 2016. This section covers the summaries of the Appliedmore » Batteries Research for Transportation Projects part 2.« less

FY2016 Advanced Batteries R&D Annual Progress Report - Part 2 of 5

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Advanced Batteries research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Battery subprogram in 2016. This section covers the summaries of the Appliedmore » Batteries Research for Transportation Projects part 1.« less

Federal Funding for Health Security in FY2018.

PubMed

Watson, Crystal; Watson, Matthew; Kirk Sell, Tara

This article is the latest in an annual series analyzing federal funding for health security programs. It examines proposed funding in the President's Budget Request for FY2018 and provides updated amounts for FY2017 and actual funding for FY2010 through FY2016. The proposed FY2018 budget for health security-related programs represents a significant decrease in funding from prior years and previous administrations. In total, the President's proposed FY2018 budget includes $12.45 billion for health security-related programs, an estimated decrease in funding of $1.25 billion, or 9%, from the estimated $13.71 billion in FY2017 and an 11% decrease from the FY2016 actual funding level of $13.99 billion. Most FY2018 health security funding ($6.67 billion, 54%) would go to programs with multiple-hazard and preparedness goals and missions, representing a 14% decrease in this funding compared to FY2017. Radiological and nuclear security programs would receive 20% ($2.48 billion) of all health security funding, a slight decrease of 2% from the prior year. Biosecurity programs would be funded at $1.53 billion (12% of health security funding) in FY2018, a decrease of 6% compared to FY2017. Chemical security programs would represent 3% ($389.7 million) of all health security funding in FY2018, a 9% decrease from the prior year. Finally, 11% of health security funding ($1.39 billion) would be dedicated to pandemic influenza and emerging infectious diseases programs, the only category of funding to see an increase (3%) above FY2017.

Novel colicin Fy of Yersinia frederiksenii inhibits pathogenic Yersinia strains via YiuR-mediated reception, TonB import, and cell membrane pore formation.

PubMed

Bosák, Juraj; Laiblová, Petra; Smarda, Jan; Dedicová, Daniela; Smajs, David

2012-04-01

A novel colicin type, designated colicin Fy, was found to be encoded and produced by the strain Yersinia frederiksenii Y27601. Colicin Fy was active against both pathogenic and nonpathogenic strains of the genus Yersinia. Plasmid YF27601 (5,574 bp) of Y. frederiksenii Y27601 was completely sequenced. The colicin Fy activity gene (cfyA) and the colicin Fy immunity gene (cfyI) were identified. The deduced amino acid sequence of colicin Fy was very similar in its C-terminal pore-forming domain to colicin Ib (69% identity in the last 178 amino acid residues), indicating pore forming as its lethal mode of action. Transposon mutagenesis of the colicin Fy-susceptible strain Yersinia kristensenii Y276 revealed the yiuR gene (ykris001_4440), which encodes the YiuR outer membrane protein with unknown function, as the colicin Fy receptor molecule. Introduction of the yiuR gene into the colicin Fy-resistant strain Y. kristensenii Y104 restored its susceptibility to colicin Fy. In contrast, the colicin Fy-resistant strain Escherichia coli TOP10F' acquired susceptibility to colicin Fy only when both the yiuR and tonB genes from Y. kristensenii Y276 were introduced. Similarities between colicins Fy and Ib, similarities between the Cir and YiuR receptors, and the detected partial cross-immunity of colicin Fy and colicin Ib producers suggest a common evolutionary origin of the colicin Fy-YiuR and colicin Ib-Cir systems.

Novel Colicin FY of Yersinia frederiksenii Inhibits Pathogenic Yersinia Strains via YiuR-Mediated Reception, TonB Import, and Cell Membrane Pore Formation

PubMed Central

Bosák, Juraj; Laiblová, Petra; Šmarda, Jan; Dědičová, Daniela

2012-01-01

A novel colicin type, designated colicin FY, was found to be encoded and produced by the strain Yersinia frederiksenii Y27601. Colicin FY was active against both pathogenic and nonpathogenic strains of the genus Yersinia. Plasmid YF27601 (5,574 bp) of Y. frederiksenii Y27601 was completely sequenced. The colicin FY activity gene (cfyA) and the colicin FY immunity gene (cfyI) were identified. The deduced amino acid sequence of colicin FY was very similar in its C-terminal pore-forming domain to colicin Ib (69% identity in the last 178 amino acid residues), indicating pore forming as its lethal mode of action. Transposon mutagenesis of the colicin FY-susceptible strain Yersinia kristensenii Y276 revealed the yiuR gene (ykris001_4440), which encodes the YiuR outer membrane protein with unknown function, as the colicin FY receptor molecule. Introduction of the yiuR gene into the colicin FY-resistant strain Y. kristensenii Y104 restored its susceptibility to colicin FY. In contrast, the colicin FY-resistant strain Escherichia coli TOP10F′ acquired susceptibility to colicin FY only when both the yiuR and tonB genes from Y. kristensenii Y276 were introduced. Similarities between colicins FY and Ib, similarities between the Cir and YiuR receptors, and the detected partial cross-immunity of colicin FY and colicin Ib producers suggest a common evolutionary origin of the colicin FY-YiuR and colicin Ib-Cir systems. PMID:22343298

An allelic series reveals essential roles for FY in plant development in addition to flowering-time control.

PubMed

Henderson, Ian R; Liu, Fuquan; Drea, Sinead; Simpson, Gordon G; Dean, Caroline

2005-08-01

The autonomous pathway functions to promote flowering in Arabidopsis by limiting the accumulation of the floral repressor FLOWERING LOCUS C (FLC). Within this pathway FCA is a plant-specific, nuclear RNA-binding protein, which interacts with FY, a highly conserved eukaryotic polyadenylation factor. FCA and FY function to control polyadenylation site choice during processing of the FCA transcript. Null mutations in the yeast FY homologue Pfs2p are lethal. This raises the question as to whether these essential RNA processing functions are conserved in plants. Characterisation of an allelic series of fy mutations reveals that null alleles are embryo lethal. Furthermore, silencing of FY, but not FCA, is deleterious to growth in Nicotiana. The late-flowering fy alleles are hypomorphic and indicate a requirement for both intact FY WD repeats and the C-terminal domain in repression of FLC. The FY C-terminal domain binds FCA and in vitro assays demonstrate a requirement for both C-terminal FY-PPLPP repeats during this interaction. The expression domain of FY supports its roles in essential and flowering-time functions. Hence, FY may mediate both regulated and constitutive RNA 3'-end processing.

Hydrologic Resources Management Program and Underground Tests Area Project FY 2003 Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

J., B C; F., E G; K., E B

This report describes FY 2003 technical studies conducted by the Chemical Biology and Nuclear Science Division (CBND) at Lawrence Livermore National Laboratory (LLNL) in support of the Hydrologic Resources Management Program (HRMP) and the Underground Test Area (UGTA) Project. These programs are administered by the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) through the Defense Programs and Environmental Restoration Divisions, respectively. HRMP-sponsored work is directed toward the responsible management of the natural resources at the Nevada Test Site (NTS), enabling its continued use as a staging area for strategic operations in support of national security.more » UGTA-funded work emphasizes the development of an integrated set of groundwater flow and contaminant transport models to predict the extent of radionuclide migration from underground nuclear testing areas at the NTS. The present report is organized on a topical basis and contains five chapters that reflect the range of technical work performed by LLNL-CBND during FY 2003. Although we have emphasized investigations that were led by CBND, we also participated in a variety of collaborative studies with other UGTA and HRMP contract organizations including the Energy and Environment Directorate at LLNL (LLNL-E&E), Los Alamos National Laboratory (LANL), the Desert Research Institute (DRI), the U.S. Geological Survey (USGS), Stoller-Navarro Joint Venture (SNJV), and Bechtel Nevada (BN).« less

[Comparisons and analysis of the spectral response functions' difference between FY-2E's and FY2C's split window channels].

PubMed

Zhang, Yong; Li, Yuan; Rong, Zhi-Guo

2010-06-01

Remote sensors' channel spectral response function (SRF) was one of the key factors to influence the quantitative products' inversion algorithm, accuracy and the geophysical characteristics. Aiming at the adjustments of FY-2E's split window channels' SRF, detailed comparisons between the FY-2E and FY-2C corresponding channels' SRF differences were carried out based on three data collections: the NOAA AVHRR corresponding channels' calibration look up tables, field measured water surface radiance and atmospheric profiles at Lake Qinghai and radiance calculated from the PLANK function within all dynamic range of FY-2E/C. The results showed that the adjustments of FY-2E's split window channels' SRF would result in the spectral range's movements and influence the inversion algorithms of some ground quantitative products. On the other hand, these adjustments of FY-2E SRFs would increase the brightness temperature differences between FY-2E's two split window channels within all dynamic range relative to FY-2C's. This would improve the inversion ability of FY-2E's split window channels.

Field Trial of an Aerosol-Based Enclosure Sealing Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harrington, Curtis; Springer, David

2015-09-01

This report presents the results from several demonstrations of a new method for sealing building envelope air leaks using an aerosol sealing process developed by the Western Cooling Efficiency Center at UC Davis. The process involves pressurizing a building while applying an aerosol sealant to the interior. As air escapes through leaks in the building envelope, the aerosol particles are transported to the leaks where they collect and form a seal that blocks the leak. Standard blower door technology is used to facilitate the building pressurization, which allows the installer to track the sealing progress during the installation and automaticallymore » verify the final building tightness. Each aerosol envelope sealing installation was performed after drywall was installed and taped, and the process did not appear to interrupt the construction schedule or interfere with other trades working in the homes. The labor needed to physically seal bulk air leaks in typical construction will not be replaced by this technology.« less

Molecular basis of the Duffy blood group system

PubMed Central

Höher, Gabriela; Fiegenbaum, Marilu; Almeida, Silvana

2018-01-01

ACKR1, located on chromosome 1q23.2, is the gene that encodes a glycoprotein expressing the Duffy blood group antigens. This gene is transcribed in two mRNA variants yielding two isoforms, encoding proteins with 338 and 336 amino acids. This review provides a general overview of the Duffy blood group to characterise and elucidate the genetic basis of this system. The Fya and Fyb antigens are encoded by co-dominant FY*A (FY*01) and FY*B (FY*02) alleles, which differ by c.125G>A (rs12075), defining the Fy(a+b−), Fy(a−b+) and Fy(a+b+) phenotypes. The Fy(a−b−) phenotype that occurs in Africans provides an explanation for the apparent absence of Plasmodium vivax in this region: this phenotype arises from homozygosity for the FY*B allele carrying a point mutation c.1-67T>C (rs2814778), which prevents Fyb antigen expression only in red blood cells. The same mutation has also been found on the FY*A allele, but it is very rare. The Fy(a−b−) phenotype in Europeans and Asians arises from mutations in the coding region of the FY*A or FY*B allele, preventing Duffy antigen expression on any cell in the body and thus are true Duffy null phenotypes. According to the International Society for Blood Transfusion, ten alleles are associated with the null expression of the Fy antigens. Furthermore, different allelic forms of FY*B modify Fyb antigen expression, which may result in very weak or equivocal serology results. The mostly common found variants, c.265C>T (rs34599082) and c.298G>A (rs13962) -previously defined in combination only with the FY*B allele - have already been observed in the FY*A allele. Thus, six alleles have been recognised and associated with weak expression of the Fy antigens. Considering the importance of the Duffy blood group system in clinical medicine, additional studies via molecular biology approaches must be performed to resolve and clarify the discrepant results that are present in the erythrocyte phenotyping. PMID:28151395

Progress in Developing Virus-like Particle Influenza Vaccines

PubMed Central

Quan, Fu-Shi; Lee, Young-Tae; Kim, Ki-Hye; Kim, Min-Chul; Kang, Sang-Moo

2016-01-01

Summary Recombinant vaccines based on virus-like particles (VLPs) or nanoparticles have been successful in their safety and efficacy in preclinical and clinical studies. The technology of expressing enveloped VLP vaccines has combined with molecular engineering of proteins in membrane-anchor and immunogenic forms mimicking the native conformation of surface proteins on the enveloped viruses. This review summarizes recent developments in influenza VLP vaccines against seasonal, pandemic, and avian influenza viruses from the perspective of use in humans. The immunogenicity and efficacies of influenza VLP vaccine in the homologous and cross-protection were reviewed. Discussions include limitations of current influenza vaccination strategies and future directions to confer broadly cross protective new influenza vaccines as well as vaccination. PMID:27058302

The Arabidopsis mutant, fy-1, has an ABA-insensitive germination phenotype.

PubMed

Jiang, Shiling; Kumar, Santosh; Eu, Young-Jae; Jami, Sravan Kumar; Stasolla, Claudio; Hill, Robert D

2012-04-01

Arabidopsis FY, a homologue of the yeast RNA 3' processing factor Pfs2p, regulates the autonomous floral transition pathway through its interaction with FCA, an RNA binding protein. It is demonstrated here that FY also influences seed dormancy. Freshly-harvested seed of the Arabidopsis fy-1 mutant germinated readily in the absence of stratification or after-ripening. Furthermore, the fy-1 mutant showed less ABA sensitivity compared with the wild type, Ler, under identical conditions. Freshly-harvested seed of fy-1 had significantly higher ABA levels than Ler, even though Ler was dormant and fy-1 germinated readily. The PPLPP domains of FY, which are required for flowering control, were not essential for the ABA-influenced repression of germination. FLC expression analysis in seeds of different genotypes suggested that the effect of FY on dormancy may not be elicited through FLC. No significant differences in CYP707A1, CYP707A2, NCED9, ABI3, and ABI4 were observed between freshly-harvested Ler and fy-1 imbibed for 48 h. GA3ox1 and GA3ox2 rapidly increased over the 48 h imbibition period for fy-1, with no significant increases in these transcripts for Ler. ABI5 levels were significantly lower in fy-1 over the 48 h imbibition period. The results suggest that FY is involved in the development of dormancy and ABA sensitivity in Arabidopsis seed.

Sonar Transducer Reliability Improvement Program, FY79 First Quarter Progress

DTIC Science & Technology

1979-06-01

The mst significant aspects are improve- ments in the gas-filling procedures for the TR155 transducers, results of accelerated aging of the TR215...thus saved the Navy approximately $19,000 during 4 months of operation. See Section 3.3.2. b. The accelerated aging of the TR-215 ( ) transducers (AN...incompatible with the various plastics and rubbers in the transducer. Further research is necessary to find and qualify fill fluids which represent the best

FY13 Progress Report on the Phase I Mini-SHINE Water Irradiations and Micro-SHINE Irradiations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Youker, Amanda J.; Krebs, John F.; Kalensky, Michael

2014-02-19

The original goal of the micro-SHINE experiments was to confirm that precipitation of uranyl peroxide can be prevented by adding a catalyst such as FeSO 4 to destroy peroxide. After successfully demonstrating that FeSO 4 is an effective catalyst for peroxide destruction, subsequent micro-SHINE solutions were used as tracers to perform a Mo-separation and recovery column experiment, a sulfate-to-nitrate conversion, and iodine speciation experiments.

FY2017 Analysis Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

During fiscal year 2017, the U.S. Department of Energy Vehicle Technologies Office (VTO) funded analysis projects supportive of VTO’s goals to pursue early stage research in vehicle and mobility system technologies to reduce petroleum dependence, increase energy reliability and security, improve transportation affordability, and promote economic growth. VTO analysis projects result in a foundation of data, analytical models, and applied analyses that provide insights into critical transportation energy problems and assist in research investment prioritization and portfolio planning.

Annual Progress Report FY-92. Volume 1

DTIC Science & Technology

1993-01-21

Billups, L Flow Cytom Resh Psychologist 12 0180 CS Hamm, C DCI 7 DESCRIPTION GRADE MOS BRANCH NAME ACTIVITY Kyle Metabolic Unit Nursing Service Supv...3349 Salata, Kalman PhD. Mitogen-Inducible T Suppressor Cell 13 Assay by Flow Cytometry (12/89) 3350 Salata, Kalman PhD. Flow Cytometric Analysis of...17 Immunotherapy (3/90) 3354 Salata, Kalman PhD. Two Way Mixed Lymphocyte Culture: 18 Analysis by Two Color Flow Cytometry (4/90) 3355 Salata, Kalman

Annual Progress Report FY 93 (Walter Reed Army Medical Center, Department of Clinical Investigation). Clinical Investigation Program. Volume 2

DTIC Science & Technology

1993-01-01

Effect of Methotrexate on Expression of Interceilular Adhesion Molecule I in Interleukin- 1 Stimulated Cultured Human Cells KEYWORDS: methotrexate...on interleukin- 1 ( IL -I) induced ICAM-l expression in cultured human fibroblasts and adenocarcinoma cells. TECHNICAL APPROACH Expression of ICAM- 1 will...incubated with IL -l to stimulate ICAM-l expression. In general, the cells responded well. ICAM- 1 was readily detectable with monoclonal antibodies and flow

US Army Medical Bioengineering Research and Development Laboratory Annual Progress Report FY1981.

DTIC Science & Technology

1981-10-01

8217 AND 0 LTPAVIOt.ET LIGHT WERE ANALYZED. TH;- OFC~ THr HE SPO ’fl 𔃻 ’’ T,_ Tfi FAl’ ARMY W~ORM SPODOPTERA FRUGIPERDA BY I)CT N. N0 𔄁 1’ .. 7 -, U...a.-~’ -J control r)o,% Aedes aegypti n experi- ipathogen. has heat, T he ’h ., Spodoptera . ’’ri spores . The ’I>r .. -. . A itus, Ae. .5 .~x .1i

Milestone Completion Report STCO04-1 AAPS: engagements with code teams, vendors, collaborators, developers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Draeger, E. W.

The Advanced Architecture and Portability Specialists team (AAPS) worked with a select set of LLNL application teams to develop and/or implement a portability strategy for next-generation architectures. The team also investigated new and updated programming models and helped develop programming abstractions targeting maintainability and performance portability. Significant progress was made on both fronts in FY17, resulting in multiple applications being significantly more prepared for the nextgeneration machines than before.

Photovoltaics program plan, FY 1991 - 1995

NASA Astrophysics Data System (ADS)

1991-10-01

This program plan describes the goals and philosophy of DOE National Photovoltaics Program and its major research and development activities for fiscal years (FY) 1991 through 1995. The plan represents a consensus among researchers and manufacturers, as well as current and potential users of photovoltaics (PV). It defines the activities that we believe are necessary to continue the rapid progress toward acceptance of photovoltaics as a serious candidate for cost-competitive electric power generation by the utility, transportation, buildings, and industrial sectors. A successful National Photovoltaics Program will help achieve many of our national priorities. The mission of the National Photovoltaics Program is to help US industry to develop photovoltaic technology for large-scale generation of economically competitive electric power in the United States, making PV a significant part of our national energy mix. To fully achieve this, we must continue to work toward the long-term goals established in our previous program plan: reducing the price of delivered electricity to 5 to 6 cents per kilowatt-hour (kWh), increasing lifetimes to 30 years, and increasing module efficiencies to 15 percent for flat-plate and 25 percent for concentrator technologies. If progress continues at its current pace, we expect that the PV industry will have installed at least 1000 megawatts (MW) of capacity in the United States and 500 MW internationally by the year 2000.

Quantification of knee vibroarthrographic signal irregularity associated with patellofemoral joint cartilage pathology based on entropy and envelope amplitude measures.

PubMed

Wu, Yunfeng; Chen, Pinnan; Luo, Xin; Huang, Hui; Liao, Lifang; Yao, Yuchen; Wu, Meihong; Rangayyan, Rangaraj M

2016-07-01

Injury of knee joint cartilage may result in pathological vibrations between the articular surfaces during extension and flexion motions. The aim of this paper is to analyze and quantify vibroarthrographic (VAG) signal irregularity associated with articular cartilage degeneration and injury in the patellofemoral joint. The symbolic entropy (SyEn), approximate entropy (ApEn), fuzzy entropy (FuzzyEn), and the mean, standard deviation, and root-mean-squared (RMS) values of the envelope amplitude, were utilized to quantify the signal fluctuations associated with articular cartilage pathology of the patellofemoral joint. The quadratic discriminant analysis (QDA), generalized logistic regression analysis (GLRA), and support vector machine (SVM) methods were used to perform signal pattern classifications. The experimental results showed that the patients with cartilage pathology (CP) possess larger SyEn and ApEn, but smaller FuzzyEn, over the statistical significance level of the Wilcoxon rank-sum test (p<0.01), than the healthy subjects (HS). The mean, standard deviation, and RMS values computed from the amplitude difference between the upper and lower signal envelopes are also consistently and significantly larger (p<0.01) for the group of CP patients than for the HS group. The SVM based on the entropy and envelope amplitude features can provide superior classification performance as compared with QDA and GLRA, with an overall accuracy of 0.8356, sensitivity of 0.9444, specificity of 0.8, Matthews correlation coefficient of 0.6599, and an area of 0.9212 under the receiver operating characteristic curve. The SyEn, ApEn, and FuzzyEn features can provide useful information about pathological VAG signal irregularity based on different entropy metrics. The statistical parameters of signal envelope amplitude can be used to characterize the temporal fluctuations related to the cartilage pathology. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The goals and accomplishments of the Energy Division of Oak Ridge National Laboratory are described in this annual progress report for Fiscal Year (FY) 1988. The Energy Division is a multidisciplinary research organization committed to (1) increasing the knowledge and understanding of the way society makes choices in energy use and energy-using technologies, (2) improving society's understanding of the environmental implications of changes in energy technology, and (3) improving and developing new energy-efficient technologies. The Energy Division's programmatic activities focus on four major areas: (1) analysis and assessment, (2) transportation and decision systems research, (3) technology research and development formore » improving the efficiency of energy and end-use technologies, and (4) electric power systems. The Division's total expenditures in FY 1988 were $44.3 million. The work is supported by the US Department of Energy, US Department of Defense, many other federal agencies, and some private organizations. Disciplines of the 139 staff members include engineering, social sciences, physical and life sciences, and mathematics and statistics.« less

Environmental restoration and waste management: Five-year plan, Fiscal Years 1992--1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Middleman, L.I.

1990-06-01

This document reflects DOE's fulfillment of a major commitment of the Environmental Restoration and Waste Management Five-Year Plan: reorganization to create an Office of Environmental Restoration and Waste Management (EM) responsible for the consolidated environmental management of nuclear-related facilities and sites formerly under the Assistant Secretaries for Defense Programs and Nuclear Energy and the Director of the Office of Energy Research. The purposes of this Plan for FY 1992--1996 are to measure progress in meeting DOE's compliance, cleanup, and waste management agenda; to incorporate a revised and condensed version of the Draft Research Development, Demonstration, Testing, and Evaluation (RDDT E)more » Plan (November 1989) to describe DOE's process for developing the new technologies critically needed to solve its environmental problems; to show DOE's current strategy and planned activities through FY 1996, including reasons for changes required to meet compliance and cleanup commitments; and to increase the involvement of other agencies and the public in DOE's planning.« less

WEC-SIM Validation Testing Plan FY14 Q4.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruehl, Kelley Michelle

2016-02-01

The WEC-Sim project is currently on track, having met both the SNL and NREL FY14 Milestones, as shown in Table 1 and Table 2. This is also reflected in the Gantt chart uploaded to the WEC-Sim SharePoint site in the FY14 Q4 Deliverables folder. The work completed in FY14 includes code verification through code-to-code comparison (FY14 Q1 and Q2), preliminary code validation through comparison to experimental data (FY14 Q2 and Q3), presentation and publication of the WEC-Sim project at OMAE 2014 [1], [2], [3] and GMREC/METS 2014 [4] (FY14 Q3), WEC-Sim code development and public open-source release (FY14 Q3), andmore » development of a preliminary WEC-Sim validation test plan (FY14 Q4). This report presents the preliminary Validation Testing Plan developed in FY14 Q4. The validation test effort started in FY14 Q4 and will go on through FY15. Thus far the team has developed a device selection method, selected a device, and placed a contract with the testing facility, established several collaborations including industry contacts, and have working ideas on the testing details such as scaling, device design, and test conditions.« less

Field Trial of an Aerosol-Based Enclosure Sealing Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harrington, Curtis; Springer, David

2015-09-01

This report presents the results from several demonstrations of a new method for sealing building envelope air leaks using an aerosol sealing process developed by the Western Cooling Efficiency Center at UC Davis. The process involves pressurizing a building while applying an aerosol sealant to the interior. As air escapes through leaks in the building envelope, the aerosol particles are transported to the leaks where they collect and form a seal that blocks the leak. Standard blower door technology is used to facilitate the building pressurization, which allows the installer to track the sealing progress during the installation and automaticallymore » verify the final building tightness. Each aerosol envelope sealing installation was performed after drywall was installed and taped, and the process did not appear to interrupt the construction schedule or interfere with other trades working in the homes. The labor needed to physically seal bulk air leaks in typical construction will not be replaced by this technology. However, this technology is capable of bringing the air leakage of a building that was built with standard construction techniques and HERS-verified sealing down to levels that would meet DOE Zero Energy Ready Homes program requirements. When a developer is striving to meet a tighter envelope leakage specification, this technology could greatly reduce the cost to achieve that goal by providing a simple and relatively low cost method for reducing the air leakage of a building envelope with little to no change in their common building practices.« less

78 FR 20089 - Public Availability of FY 2012 Service Contract Inventories

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-03

... DEPARTMENT OF AGRICULTURE Office of Procurement and Property Management Public Availability of FY... Management, Department of Agriculture. ACTION: Notice of public availability of FY 2012 Service Contract... availability of the FY 2012 Service Contract inventory. This inventory provides information on FY 2012 service...

Appropriations for FY1999 : Department of Transportation and related agencies

DOT National Transportation Integrated Search

1998-12-01

For FY1999, the U.S. Department of Transportation (DOT) requested total funding of approximately $43 billion, a 1% increase over the FY1998 enacted level of $39 billion. The FY1999 budget request for the DOT was similar in may respects to the FY 1998...

Structural Mechanics Division research and technology plans for FY 1990 and accomplishments for FY 1989

NASA Technical Reports Server (NTRS)

Bales, Kay S.

1990-01-01

The Objectives, FY 1990 Plans, Approach, and FY 1990 Milestones for the Structural Mechanics Division's research programs are presented. FY 1989 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

Structures and Dynamics Division research and technology plans for FY 1986 and accomplishments for FY 1985

NASA Technical Reports Server (NTRS)

Bales, K. S.

1986-01-01

Presented are the Objectives, FY 1986 Plans, Approach, and FY 1986 Milestones for the Structures and Dynamics Division's research programs. FY 1985 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

Fy(a)/Fy(b) antigen polymorphism in human erythrocyte Duffy antigen affects susceptibility to Plasmodium vivax malaria.

PubMed

King, Christopher L; Adams, John H; Xianli, Jia; Grimberg, Brian T; McHenry, Amy M; Greenberg, Lior J; Siddiqui, Asim; Howes, Rosalind E; da Silva-Nunes, Monica; Ferreira, Marcelo U; Zimmerman, Peter A

2011-12-13

Plasmodium vivax (Pv) is a major cause of human malaria and is increasing in public health importance compared with falciparum malaria. Pv is unique among human malarias in that invasion of erythrocytes is almost solely dependent on the red cell's surface receptor, known as the Duffy blood-group antigen (Fy). Fy is an important minor blood-group antigen that has two immunologically distinct alleles, referred to as Fy(a) or Fy(b), resulting from a single-point mutation. This mutation occurs within the binding domain of the parasite's red cell invasion ligand. Whether this polymorphism affects susceptibility to clinical vivax malaria is unknown. Here we show that Fy(a), compared with Fy(b), significantly diminishes binding of Pv Duffy binding protein (PvDBP) at the erythrocyte surface, and is associated with a reduced risk of clinical Pv in humans. Erythrocytes expressing Fy(a) had 41-50% lower binding compared with Fy(b) cells and showed an increased ability of naturally occurring or artificially induced antibodies to block binding of PvDBP to their surface. Individuals with the Fy(a+b-) phenotype demonstrated a 30-80% reduced risk of clinical vivax, but not falciparum malaria in a prospective cohort study in the Brazilian Amazon. The Fy(a+b-) phenotype, predominant in Southeast Asian and many American populations, would confer a selective advantage against vivax malaria. Our results also suggest that efficacy of a PvDBP-based vaccine may differ among populations with different Fy phenotypes.

A novel FY allele in Brazilians.

PubMed

Castilho, L; Rios, M; Pellegrino, J; Saad, S T O; Costa, F F; Reid, M E

2004-10-01

The GATA box single nucleotide polymorphism (SNP) at position -33 (T>C) in Blacks silences the expression of FY*B in erythrocytes, and the substitution 265 C>T, together with 298 G>A, weakens the Fy(b) antigen (Fy(x)). Individuals with these phenotypes/genotypes who receive Fy(b+) blood are unlikely to be alloimmunized to Fy(b) because, in the presence of 265 T, the Fy(b) antigen is expressed, and in the case of -33 C, other tissues express Duffy protein and probably the Fy(b) antigen. We studied samples from 361 blood donors (182 of African ancestry and 179 of Caucasian ancestry) by haemagglutination and polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP). Forty Caucasian and 130 donors of African ancestry were serologically Fy(b-); among these, the majority of the donors of African ancestry had FY*B with the GATA SNP, while the majority of Caucasians typing Fy(b-) had FY*B with 265 T/298 A SNPs. Six of the Fy(b-) donors (three Africans and three Caucasians) had both GATA and 265/298 SNPs, and six donors of Caucasian ancestry apparently had a GATA SNP. Samples from two donors - one African and one Caucasian with an unusual MspA1I-RFLP pattern - were sequenced and found to have a novel SNP (145 G>T) co-existent with 265 C>T and 298 G>A SNPs. These findings highlight the importance of establishing the incidence and nature of molecular events that impact on Duffy expression in different populations.

The Arabidopsis mutant, fy-1, has an ABA-insensitive germination phenotype

PubMed Central

Jiang, Shiling; Kumar, Santosh; Eu, Young-Jae; Jami, Sravan Kumar; Stasolla, Claudio; Hill, Robert D.

2012-01-01

Arabidopsis FY, a homologue of the yeast RNA 3' processing factor Pfs2p, regulates the autonomous floral transition pathway through its interaction with FCA, an RNA binding protein. It is demonstrated here that FY also influences seed dormancy. Freshly-harvested seed of the Arabidopsis fy-1 mutant germinated readily in the absence of stratification or after-ripening. Furthermore, the fy-1 mutant showed less ABA sensitivity compared with the wild type, Ler, under identical conditions. Freshly-harvested seed of fy-1 had significantly higher ABA levels than Ler, even though Ler was dormant and fy-1 germinated readily. The PPLPP domains of FY, which are required for flowering control, were not essential for the ABA-influenced repression of germination. FLC expression analysis in seeds of different genotypes suggested that the effect of FY on dormancy may not be elicited through FLC. No significant differences in CYP707A1, CYP707A2, NCED9, ABI3, and ABI4 were observed between freshly-harvested Ler and fy-1 imbibed for 48 h. GA3ox1 and GA3ox2 rapidly increased over the 48 h imbibition period for fy-1, with no significant increases in these transcripts for Ler. ABI5 levels were significantly lower in fy-1 over the 48 h imbibition period. The results suggest that FY is involved in the development of dormancy and ABA sensitivity in Arabidopsis seed. PMID:22282534

Electron microscopic studies of mitosis in amebae. I. Amoeba proteus.

PubMed

ROTH, L E; OBETZ, S W; DANIELS, E W

1960-09-01

Individual organisms of Amoeba proteus have been fixed in buffered osmium tetroxide in either 0.9 per cent NaCl or 0.01 per cent CaCl(2), sectioned, and studied in the electron microscope in interphase and in several stages of mitosis. The helices typical of interphase nuclei do not coexist with condensed chromatin and thus either represent a DNA configuration unique to interphase or are not DNA at all. The membranes of the complex nuclear envelope are present in all stages observed but are discontinuous in metaphase. The inner, thick, honeycomb layer of the nuclear envelope disappears during prophase, reappearing after telophase when nuclear reconstruction is in progress. Nucleoli decrease in size and number during prophase and re-form during telophase in association with the chromatin network. In the early reconstruction nucleus, the nucleolar material forms into thin, sheet-like configurations which are closely associated with small amounts of chromatin and are closely applied to the inner, partially formed layer of the nuclear envelope. It is proposed that nucleolar material is implicated in the formation of the inner layer of the envelope and that there is a configuration of nucleolar material peculiar to this time. The plasmalemma is partially denuded of its fringe-like material during division.

ELECTRON MICROSCOPIC STUDIES OF MITOSIS IN AMEBAE

PubMed Central

Roth, L. E.; Obetz, S. W.; Daniels, E. W.

1960-01-01

Individual organisms of Amoeba proteus have been fixed in buffered osmium tetroxide in either 0.9 per cent NaCl or 0.01 per cent CaCl2, sectioned, and studied in the electron microscope in interphase and in several stages of mitosis. The helices typical of interphase nuclei do not coexist with condensed chromatin and thus either represent a DNA configuration unique to interphase or are not DNA at all. The membranes of the complex nuclear envelope are present in all stages observed but are discontinuous in metaphase. The inner, thick, honeycomb layer of the nuclear envelope disappears during prophase, reappearing after telophase when nuclear reconstruction is in progress. Nucleoli decrease in size and number during prophase and re-form during telophase in association with the chromatin network. In the early reconstruction nucleus, the nucleolar material forms into thin, sheet-like configurations which are closely associated with small amounts of chromatin and are closely applied to the inner, partially formed layer of the nuclear envelope. It is proposed that nucleolar material is implicated in the formation of the inner layer of the envelope and that there is a configuration of nucleolar material peculiar to this time. The plasmalemma is partially denuded of its fringe-like material during division. PMID:13743845

7 CFR 1424.5 - Agreement process.

Code of Federal Regulations, 2010 CFR

2010-01-01

... basis. (b) Sign-up each FY will be held for 30 calendar days beginning for: (1) FY 2003 on the date of... participate, an eligible producer must submit a signed agreement during the FY sign-up period. Agreements may be for single or multiple FY's. However, multiple FY agreements require producers to submit annual...

Structures and Dynamics Division research and technology plans for FY 1988 and accomplishments for FY 1987

NASA Technical Reports Server (NTRS)

Bales, Kay S.

1988-01-01

Presented are the Objectives, FY 1988 Plans, Approach, and FY 1988 Milestones for the Structures and Dynamics Division (Langley Research Center) research programs. FY 1987 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

Structures and Dynamics Division research and technology plans for FY 1987 and accomplishments for FY 1986

NASA Technical Reports Server (NTRS)

Bales, Kay S.

1987-01-01

This paper presents the Objectives, FY 1987 Plans, Approach, and FY 1987 Milestones for the Structures and Dynamics Division's research programs. FY 1986 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

Structures and Dynamics Division research and technology plans for FY 1985 and accomplishments for FY 1984

NASA Technical Reports Server (NTRS)

Bales, K. S.

1985-01-01

The objectives, FY 1985 plans, approach, and FY 1985 milestones for the Structures and Dynamics Division's research programs are presented. The FY 1984 accomplishments are presented where applicable. This information is useful in program coordination with other government organizations in areas of mutual interest.

Methods of Technological Forecasting,

DTIC Science & Technology

1977-05-01

Trend Extrapolation Progress Curve Analogy Trend Correlation Substitution Analysis or Substitution Growth Curves Envelope Curve Advances in the State of...the Art Technological Mapping Contextual Mapping Matrix Input-Output Analysis Mathematical Models Simulation Models Dynamic Modelling. CHAPTER IV...Generation Interaction between Needs and Possibilities Map of the Technological Future — (‘ross- Impact Matri x Discovery Matrix Morphological Analysis

Detection of antibodies reacting with the antithetical duffy blood group antigens Fy(a) and Fy(b) using recombinant fusion proteins containing the duffy extracellular domain.

PubMed

Sheffield, William P; Bhakta, Varsha; Branch, Donald R; Denomme, Gregory A

2006-12-01

Detecting blood group-specific antibodies in patient sera is essential to the management of blood transfusions or pregnancies. We produced the antithetical forms of the 65 amino acid extracellular domain (ECD) of the Duffy (Fy) blood group protein fused to glutathione sulfotransferase (GST): GST-Fy(a); and GST-Fy(b), differing only in Gly or Asp at position 44, respectively. The purified recombinant proteins were recognized more effectively by reference polyclonal or monoclonal antibodies than the antithetical Fy specificity by either ELISA or immunoblotting. Combined immunoblot and ELISA tests performed at 1:200 dilutions of sera using the recombinant proteins gave results in agreement with undiluted sera and agglutination for 17/19 alloimmunized patients. At 1:200, agglutination detected anti-Fy(a) or anti-Fy(b) in only three of 12 samples that were positive by ELISA. Recombinant ECD-Fy proteins are suitable and sensitive reagents for the detection of anti-Fy that use technology amenable to automation and/or miniaturization and avoid the need for intact red cells.

Ultrasound monitoring of inter-knee distances during gait.

PubMed

Lai, Daniel T H; Wrigley, Tim V; Palaniswami, M

2009-01-01

Knee osteoarthritis is an extremely common, debilitating disease associated with pain and loss of function. There is considerable interest in monitoring lower limb alignment due to its close association with joint overload leading to disease progression. The effects of gait modifications that can lower joint loading are of particular interest. Here we describe an ultrasound-based system for monitoring an important aspect of dynamic lower limb alignment, the inter-knee distance during walking. Monitoring this gait parameter should facilitate studies in reducing knee loading, a primary risk factor of knee osteoarthritis progression. The portable device is composed of an ultrasound sensor connected to an Intel iMote2 equipped with Bluetooth wireless capability. Static tests and calibration results show that the sensor possesses an effective beam envelope of 120 degrees, with maximum distance errors of 10% at the envelope edges. Dynamic walking trials reveal close correlation of inter-knee distance trends between that measured by an optical system (Optotrak Certus NDI) and the sensor device. The maximum average root mean square error was found to be 1.46 cm. Future work will focus on improving the accuracy of the device.

Lead Slowing-Down Spectrometry for Spent Fuel Assay: FY11 Status Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Warren, Glen A.; Casella, Andrew M.; Haight, R. C.

2011-08-01

Executive Summary Developing a method for the accurate, direct, and independent assay of the fissile isotopes in bulk materials (such as used fuel) from next-generation domestic nuclear fuel cycles is a goal of the Office of Nuclear Energy, Fuel Cycle R&D, Material Protection and Control Technology (MPACT) Campaign. To meet this goal, MPACT supports a multi-institutional collaboration to study the feasibility of Lead Slowing Down Spectroscopy (LSDS). This technique is an active nondestructive assay method that has the potential to provide independent, direct measurement of Pu and U isotopic masses in used fuel with an uncertainty considerably lower than themore » approximately 10% typical of today’s confirmatory assay methods. This document is a progress report for FY2011 collaboration activities. Progress made by the collaboration in FY2011 continues to indicate the promise of LSDS techniques applied to used fuel. PNNL developed an empirical model based on calibration of the LSDS to responses generated from well-characterized used fuel. The empirical model demonstrated the potential for the direct and independent assay of the sum of the masses of 239Pu and 241Pu to within approximately 3% over a wide used fuel parameter space. Similar results were obtained using a perturbation approach developed by LANL. Benchmark measurements have been successfully conducted at LANL and at RPI using their respective LSDS instruments. The ISU and UNLV collaborative effort is focused on the fabrication and testing of prototype fission chambers lined with ultra-depleted 238U and 232Th, and uranium deposition on a stainless steel disc using spiked U3O8 from room temperature ionic liquid was successful, with improving thickness obtained. In FY2012, the collaboration plans a broad array of activities. PNNL will focus on optimizing its empirical model and minimizing its reliance on calibration data, as well continuing efforts on developing an analytical model. Additional measurements are planned at LANL and RPI. LANL measurements will include a Pu sample, which is expected to provide more counts at longer slowing-down times to help identify discrepancies between experimental data and MCNPX simulations. RPI measurements will include the assay of an entire fresh fuel assembly for the study of self-shielding effects as well as the ability to detect diversion by detecting a missing fuel pin in the fuel assembly. The development of threshold neutron sensors will continue, and UNLV will calibrate existing ultra-depleted uranium deposits at ISU.« less

The Structure of Young Stellar Systems: Establishing the Initial Conditions for Planet Formation

NASA Technical Reports Server (NTRS)

Blake, Geoffrey A.

2004-01-01

FYO1-FY03 Origins support to the PI had been as part of an effort involving Profs. Blake, van Dishoeck and L.G. Mundy of the University of Maryland. As outlined below, the merging of BIMA+OVRO into the Combined Array for Research in Millimeter Astronomy (CARMA) and our mutual involvement in the Spitzer Legacy Science program now provides a more natural means of continuing the Caltech/Maryland collaboration. In addition, the spectroscopy/radiative transfer programs led by Profs. Blake, Hogerheijde, and van Dishoeck form a more cohesive basis for a single proposal. Students supported by our previous Origins grant have been involved in making some of the first sub-arcsecond resolution images of the morphology and chemistry of individual YSOs at OVRO and BIMA, in the analysis of IR spectra taken by ISO, and in continuing exploratory IR diffraction-limited imaging and spectroscopy at the Keck and VLT observatories. Notable scientific accomplishments in the past grant period include: 1) detecting high density and temperature hot cores in the dynamically accreting envelopes of low mass protostars that contain significant quantities of complex, prebioitc molecules, 2) imaging chemical and isotopic zonation in the outer regions of T Tauri star accretion disks, particularly fractional ionization and D/H studies, 3) acquiring and modeling the first extensive CO v = 1 approaches 0 spectroscopy survey of the terrestrial planet-forming region of circumstellar accretion disks, and 4) optimizing detailed radiative transfer modeling of the molecular and dust emission from YSO envelopes and from comets, including a new parallelized implementation.

Navy Force Structure and Shipbuilding Plans: Background and Issues for Congress

DTIC Science & Technology

2014-08-01

submarines (SSBNs) 12b 12-14b 12b 12b 14 14 14 14 14 Cruise missile submarines (SSGNs) 0c 0-4c 4c 0c 4 4 4 4 2 or 4d Attack submarines ( SSNs ...aircraft carrier 1 1 Virginia ( SSN -774) class attack submarine 2 2 2 2 2 10 Arleigh Burke (DDG-51) class destroyer 2 2 2 2 2 10 Littoral Combat Ship...shows the Navy’s FY2015 30-year (FY2015-FY2044) shipbuilding plan. Table 3. Navy FY2015 30-Year (FY2015-FY2044) Shipbuilding Plan FY CVN LSC SSC SSN

Abscisic acid does not disrupt either the Arabidopsis FCA-FY interaction or its rice counterpart in vitro.

PubMed

Jang, Yun Hee; Lee, Jeong Hwan; Kim, Jeong-Kook

2008-12-01

We examined the effect of (+)-ABA on the in vitro interaction of rice FCA and FY homologs, OsFCA and OsFY. From this analysis, we found no disruption of the OsFCA-OsFY complexes by ABA treatment. This result prompted us to examine the effect of ABA on the FCA-FY interaction. In these experiments, we could not reproduce the inhibitory effect of (+)-ABA on the interaction between FCA and FY. Based on these combined results, we believe that the inhibitory effect of (+)-ABA on the FCA-FY interaction should be cautiously reconsidered.

Navy Force Structure and Shipbuilding Plans: Background and Issues for Congress

DTIC Science & Technology

2016-09-21

some observers regarding the current and future size and capabilities of the Navy. The Navy’s proposed FY2017 budget requests funding for the...An October 2015 Congressional Budget Office (CBO) report on the Navy’s FY2015 30-year shipbuilding plan estimates that the plan would require 11.5...shipbuilding budget , its proposed FY2017-FY2021 five-year shipbuilding plan, and its 30-year (FY2017-FY2046) shipbuilding plan include the following:  the

Verification and Validation of a Navy ESPC Hindcast with Loosely Coupled Data Assimilation

NASA Astrophysics Data System (ADS)

Metzger, E. J.; Barton, N. P.; Smedstad, O. M.; Ruston, B. C.; Wallcraft, A. J.; Whitcomb, T. R.; Ridout, J. A.; Franklin, D. S.; Zamudio, L.; Posey, P. G.; Reynolds, C. A.; Phelps, M.

2016-12-01

The US Navy is developing an Earth System Prediction Capability (ESPC) to provide global environmental information to meet Navy and Department of Defense (DoD) operations and planning needs from the upper atmosphere to under the sea. It will be a fully coupled global atmosphere/ocean/ice/wave/land prediction system providing daily deterministic forecasts out to 16 days at high horizontal and vertical resolution, and daily probabilistic forecasts out to 45 days at lower resolution. The system will run at the Navy DoD Supercomputing Resource Center with an initial operational capability scheduled for the end of FY18 and the final operational capability scheduled for FY22. The individual model and data assimilation components include: atmosphere - NAVy Global Environmental Model (NAVGEM) and Naval Research Laboratory (NRL) Atmospheric Variational Data Assimilation System - Accelerated Representer (NAVDAS-AR); ocean - HYbrid Coordinate Ocean Model (HYCOM) and Navy Coupled Ocean Data Assimilation (NCODA); ice - Community Ice CodE (CICE) and NCODA; WAVEWATCH III™ and NCODA; and land - NAVGEM Land Surface Model (LSM). Currently, NAVGEM/HYCOM/CICE are three-way coupled and each model component is cycling with its respective assimilation scheme. The assimilation systems do not communicate with each other, but future plans call for these to be coupled as well. NAVGEM runs with a 6-hour update cycle while HYCOM/CICE run with a 24-hour update cycle. The T359L50 NAVGEM/0.08° HYCOM/0.08° CICE system has been integrated in hindcast mode and verification/validation metrics have been computed against unassimilated observations and against stand-alone versions of NAVGEM and HYCOM/CICE. This presentation will focus on typical operational diagnostics for atmosphere, ocean, and ice analyses including 500 hPa atmospheric height anomalies, low-level winds, temperature/salinity ocean depth profiles, ocean acoustical proxies, sea ice edge, and sea ice drift. Overall, the global coupled ESPC system is performing with comparable skill to the stand-alone systems at the nowcast time.

FY92 Progress Report for the Gyrotron Backward-Wave-Oscillator Experiment

DTIC Science & Technology

1993-07-01

C. SAMPLE CABLE CALIBRATION 23 D. ASYST CHANNEL SETUPS 26 E. SAMPLE MAGNET INPUT DATA DECK FOR THE GYRO-BWO 32 F. SAMPLE EGUN INPUT DATA DECK FOR THE...of the first coil of the Helmholtz pair; zero also corresponds to the diode end of the experiment). Another computer code used was the EGUN code (Ref...a short computer program was written to superimpose the two magnetic fields; DC and Helmholtz). An example of an EGUN input data file is included in

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rutqvist, Jonny; Blanco-Martin, Laura; Molins, Sergi

In this report, we present FY2015 progress by Lawrence Berkeley National Laboratory (LBNL) related to modeling of coupled thermal-hydrological-mechanical-chemical (THMC) processes in salt and their effect on brine migration at high temperatures. This is a combined milestone report related to milestone Salt R&D Milestone “Modeling Coupled THM Processes and Brine Migration in Salt at High Temperatures” (M3FT-15LB0818012) and the Salt Field Testing Milestone (M3FT-15LB0819022) to support the overall objectives of the salt field test planning.

US Army Institute of Surgical Research Annual Research Progress Report FY 1982.

DTIC Science & Technology

1982-10-01

arterial blood gases, respiratory rate, daily chest roentgenograms), cardiovascular (blood pressure, central venous pressure, cardiac output measured...confirmed by the finding that central venous plasma histamine rose from 3.79 + 0.86 to 77.58 + 27.28 and 74.22 + 32.79 ng/ml at one and two minutes postburn...wounds at 2 - 4 weeks after injury. Central venous indwelling catheters were placed via the right jugular vein on the day prior to use as previously

Walter Reed Army Medical Center, Washington, DC Annual Progress Report FY-89. Volume 2. Part 1

DTIC Science & Technology

1990-01-02

recurrent head and neck cancer who meet the eligibility requirements and consent to the protocol will have central venous catheter placed (if one is...DATE: 06/29/89 WORK UNIT # 6220 DETAIL SUMMARY SHEET TITLE: Epidemiology of HIV In Pediatric and Perinatal Patients - A Natural History Study...of HIV in clinical samples. 16 I I REPORT DATE: 04/04/89 WORK UNIT # 8804 DETAIL SUMMARY SHEET TITLE: The Natural History of HIV Infection and Disease

Annual Progress Report FY-91. Volume 1 and 2.

DTIC Science & Technology

1992-03-12

Pulmonary Med Tech 11 0644 GS Berger, TA Allergy Microbiologist 12 0403 GS Billups, L Flow Cytom Chemist 12 1320 GS Vacant Pulmonary Kyle Metabolic Unit...Reactions 11 (11/89) 3349 Salata, Kalman PhD. Mitogen-Inducible T Suppressor Cell 12 Assay by Flow Cytometry (12/89) 3350 Salata, Kalman PhD. Flow ...3/90) 3354 Salata, Kalman PhD. Two Way Mixed Lymphocyte Culture: 17 Analysis by Two Color Flow Cytometry (4/90) 3355 Salata, Kalman PhD. Effect of

Department of Clinical Investigation, Annual Research Progress Report Fiscal Year 1988

DTIC Science & Technology

1988-09-30

Enanthate with Testolactone. Clin Res 36( 1 ): 122A, 1938 Friedl KE, Hannan CJ, Effect of Eye Color on Heart Rate Mader TH, Patience TH, Response to...J Clin Oncol 6( 1 ): 154-57, 1988 11 PUBLICATIONS - MAMC - FY 88 Schoenfeld SL, McCulloch DK Insulin Autoantibody Detection in Nuovo JA, Klaff LJ...Acid:CoASH Ligase (AMP). Effects of Insulin , Glucagon, Glucocorticoids, and Thyroid Hormones 27 PI and No. Status Page JONES, RE 0 Investigations into the

Reaction Rate Data. Number 63. Resume of FY 78 DNA-Sponsored Chemistry/Physics Reaction Rate Research Programs.

DTIC Science & Technology

1977-12-01

related progress p reports concerning the DNA-sponsored effo rt s described herein. - ~~~ Submission of other pertinent informat ion of a related nature...Work Unit 06). 5 5. Atmospheric Chemical Sensitivity and Modeling Invesriga nons—M. Scheibe, MRC (Work Unit 09). 5 6. Low Energy Cross Sections for...Debris Metal Ions—R. Neynaber, D. Vroom . and l.A. Rutherford, IRT, Inc. (Work Unit 12). 5 7. E and F Region Rate Coefficients for Excited Positive

Role of SRC-3delta4 in the Progression and Metastasis of Castration-Resistant Prostate Cancer

DTIC Science & Technology

2014-12-01

tyrosine phosphorylation of SRC-3∆4, which was inhibited by the treatment with EGFR inhibitor AG1478. Mutation of Y1159 to phenylalanine (Y1159F...Y1159 to phenylalanine (Y1159F) greatly reduced SRC-3∆4/AR interaction that is stimulated by EGF. Figure 7 Overexpression of SRC-3∆4 promoted...adhesion turnover and matrix metalloproteinase expression. Cancer research 68, 5460-5468. 6. Chung, A.C., Zhou, S., Liao, L ., Tien, J.C., Greenberg

Research and Technology Objectives and Plans Summary (RTOPS)

NASA Technical Reports Server (NTRS)

1990-01-01

The NASA research and technology program for FY 1990 is presented. The summary portions is compiled of each of the RTOPs (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP summary is designed to facilitate communication and coordination among concerned technical personnel in government, industry, and universities. The first section containing citations and abstracts of the RTOPs is followed by four indices: Subject; Technical Monitor; Responsible NASA Organization; and RTOP number.

NASA's Nuclear Thermal Propulsion Project

NASA Technical Reports Server (NTRS)

Houts, Mike; Mitchell, Sonny; Kim, Tony; Borowski, Stan; Power, Kevin; Scott, John; Belvin, Anthony; Clement, Steve

2015-01-01

HEOMD's (Human Exploration and Operations Mission Directorate) AES (Advanced Exploration Systems) Nuclear Thermal Propulsion (NTP) project is making significant progress. First of four FY 2015 milestones achieved this month. Safety is the highest priority for NTP (as with other space systems). After safety comes affordability. No centralized capability for developing, qualifying, and utilizing an NTP system. Will require a strong, closely integrated team. Tremendous potential benefits from NTP and other space fission systems. No fundamental reason these systems cannot be developed and utilized in a safe, affordable fashion.

Federal Energy Management Program FY 2017 Budget At-A-Glance

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2016-03-01

With more than 350,000 buildings and 600,000 vehicles, the federal government is America’s largest single energy consumer. There is a tremendous opportunity and responsibility to lead by example in cutting energy waste and advancing America’s clean energy future. The progress the federal government has made to date, through public-private partnerships and successful approaches, should be leveraged to show leadership to the nation and continue to make significant contributions to our national energy and environmental goals.

Department of Clinical Investigation Annual Research Progress Report, Fiscal Year 1986,

DTIC Science & Technology

1986-10-01

factors for diarrhea, regardless of child-care location, included age, sex , and number of auxilary care sites. Infection control measures used in the Ft...Eugenia R. GSS 0318 Maintenance Worker KAEO, Curtis WG7 4749 FUNDING F~Y 86 MWEDCASE Equipment 54,400.00 Capital Equipment 25,376.00 Civilian Salaries...Overdose Revisited. Ann Ener Med 15(11):1349-52, 1986 Parks FB, Calabro Do, burkle M., Jr: Addisonian Crisis in an Adolescent Female : A Case Report

76 FR 148 - Medicaid Program; Final FY 2009 and Preliminary FY 2011 Disproportionate Share Hospital...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-03

... Federal share) IMD and other mental health facility DSH expenditures applicable to the State's FY 1995 DSH... State's total computable DSH expenditures attributable to the FY 1995 DSH allotment for mental health... health DSH expenditures applicable to the State's FY 1995 DSH allotment by the total computable amount of...

Biennial Operating Budget Request, FY 2007-2009

ERIC Educational Resources Information Center

Connecticut Department of Higher Education (NJ1), 2006

2006-01-01

The Connecticut public higher education community requests an overall general fund/operating fund budget of $1.95 billion for FY 2008 and $2.02 billion for FY 2009. In FY 2008, this includes general fund current service support of $717.7 million and other funding requests of $53.0 million. For FY 2009, the general fund current service request is…

[Breast Cancer: Value-Based Healthcare, Costs and Financing].

PubMed

Harfouche, Ana; Silva, Silvia; Faria, João; Araújo, Rui; Gouveia, António; Lacerda, Maria; D'Orey, Luís

2017-11-29

Breast cancer is the second most common oncological disease worldwide. To analyse the new disease specific funding programme (breast cancer) implemented at the Francisco Gentil Portuguese Institute of Oncology, Lisbon Center (Instituto Português de Oncologia de Lisboa Francisco Gentil), the actual costs of the patients were examined using activity-based costing as a costing methodology. This study addresses the following question: "How much does it cost to treat breast cancer per 'patient-month' compared to the monthly fixed 'funding envelope'?". The study cohort consisted of 807 patients, corresponding to all the patients eligible for the new disease specific funding programme and who were enrolled during the first year of implementation. Activity-based costing was used to calculate the total real costs per stage of disease and per 'patient-month' as well as the deviation from the monthly fixed 'funding envelope'. The total costs were 6.6 M€, whereas the total funding was 5.2 M€ for a total of 5648 'patient-months'. In 2014, the balance difference between the funding obtained and the actual costs was -1.4 €M for the cohort of 807 patients. The extreme cases of differences in cost per 'patient-month' compared to the monthly fixed 'funding envelope' were (i) stage 0/Tis, with higher funding at 415.23 € per 'patient-month', and (ii) stage IIIC, with lower funding at 1062.79 € per 'patient-month'. The 'patient-month' cost, regardless of disease stage was 1170.29 €. The median deviation per 'patient-month' was negative (241.21 €) compared to the monthly fixed 'funding envelope' of 929.08 € in the first year. Establishing activity-based costing - funding models will be crucial for the future sustainability of the healthcare sector.

Unique activity spectrum of colicin FY: all 110 characterized Yersinia enterocolitica isolates were colicin FY susceptible.

PubMed

Bosák, Juraj; Micenková, Lenka; Vrba, Martin; Ševčíková, Alena; Dědičová, Daniela; Garzetti, Debora; Šmajs, David

2013-01-01

Colicin FY is a plasmid encoded toxin that recognizes a yersinia-specific outer membrane protein (YiuR) as a receptor molecule. We have previously shown that the activity spectrum of colicin FY comprises strains of the genus Yersinia. In this study, we analyzed the activity of colicin FY against 110 Yersinia enterocolitica isolates differing in geographical origin and source. All isolates were characterized through analysis of 16S rRNA genes, serotyping, biotyping, restriction profiling of genomic DNA, detection of virulence markers and susceptibility to antibiotics. This confirmed the broad variability of the collection, in which all 110 Y. enterocolitica isolates, representing 77 various strains, were inhibited by colicin FY. Although isolates showed variable levels of susceptibility to colicin FY, it was not associated with any strain characteristic. The universal susceptibility of Y. enterocolitica strains to colicin FY together with the absence of activity towards strains outside the Yersinia genus suggests potential therapeutic applications for colicin FY.

Unique Activity Spectrum of Colicin FY: All 110 Characterized Yersinia enterocolitica Isolates Were Colicin FY Susceptible

PubMed Central

Bosák, Juraj; Micenková, Lenka; Vrba, Martin; Ševčíková, Alena; Dědičová, Daniela; Garzetti, Debora; Šmajs, David

2013-01-01

Colicin FY is a plasmid encoded toxin that recognizes a yersinia-specific outer membrane protein (YiuR) as a receptor molecule. We have previously shown that the activity spectrum of colicin FY comprises strains of the genus Yersinia. In this study, we analyzed the activity of colicin FY against 110 Yersinia enterocolitica isolates differing in geographical origin and source. All isolates were characterized through analysis of 16S rRNA genes, serotyping, biotyping, restriction profiling of genomic DNA, detection of virulence markers and susceptibility to antibiotics. This confirmed the broad variability of the collection, in which all 110 Y. enterocolitica isolates, representing 77 various strains, were inhibited by colicin FY. Although isolates showed variable levels of susceptibility to colicin FY, it was not associated with any strain characteristic. The universal susceptibility of Y. enterocolitica strains to colicin FY together with the absence of activity towards strains outside the Yersinia genus suggests potential therapeutic applications for colicin FY. PMID:24339971

FY2014 Energy Storage R&D Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

The Energy Storage research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Energy Storage subprogram in 2014. You can download individual sections at themore » following website, http://energy.gov/eere/vehicles/downloads/vehicle-technologies-office-2014-energy-storage-rd-annual-report.« less

Midwest Nuclear Science and Engineering Consortium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dr. Wynn Volkert; Dr. Arvind Kumar; Dr. Bryan Becker

2010-12-08

The objective of the Midwest Nuclear Science and Engineering Consortium (MNSEC) is to enhance the scope, quality and integration of educational and research capabilities of nuclear sciences and engineering (NS/E) programs at partner schools in support of the U.S. nuclear industry (including DOE laboratories). With INIE support, MNSEC had a productive seven years and made impressive progress in achieving these goals. Since the past three years have been no-cost-extension periods, limited -- but notable -- progress has been made in FY10. Existing programs continue to be strengthened and broadened at Consortium partner institutions. The enthusiasm generated by the academic, state,more » federal, and industrial communities for the MNSEC activities is reflected in the significant leveraging that has occurred for our programs.« less

FY2016 Advanced Batteries R&D Annual Progress Report - Part 5 of 5

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Advanced Batteries research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for projects focusing on batteries for plug-in electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush. This report describes the progress made on the research and development projects funded by the Battery subprogram in 2016. This section cover Advanced Battery Materials Research (BMR)more » part 2, Battery500 Innovation Centers project summaries, and appendices.« less

Optimization of HIV-1 Envelope DNA Vaccine Candidates within Three Different Animal Models, Guinea Pigs, Rabbits and Cynomolgus Macaques.

PubMed

Borggren, Marie; Vinner, Lasse; Andresen, Betina Skovgaard; Grevstad, Berit; Repits, Johanna; Melchers, Mark; Elvang, Tara Laura; Sanders, Rogier W; Martinon, Frédéric; Dereuddre-Bosquet, Nathalie; Bowles, Emma Joanne; Stewart-Jones, Guillaume; Biswas, Priscilla; Scarlatti, Gabriella; Jansson, Marianne; Heyndrickx, Leo; Grand, Roger Le; Fomsgaard, Anders

2013-07-19

HIV-1 DNA vaccines have many advantageous features. Evaluation of HIV-1 vaccine candidates often starts in small animal models before macaque and human trials. Here, we selected and optimized DNA vaccine candidates through systematic testing in rabbits for the induction of broadly neutralizing antibodies (bNAb). We compared three different animal models: guinea pigs, rabbits and cynomolgus macaques. Envelope genes from the prototype isolate HIV-1 Bx08 and two elite neutralizers were included. Codon-optimized genes, encoded secreted gp140 or membrane bound gp150, were modified for expression of stabilized soluble trimer gene products, and delivered individually or mixed. Specific IgG after repeated i.d. inoculations with electroporation confirmed in vivo expression and immunogenicity. Evaluations of rabbits and guinea pigs displayed similar results. The superior DNA construct in rabbits was a trivalent mix of non-modified codon-optimized gp140 envelope genes. Despite NAb responses with some potency and breadth in guinea pigs and rabbits, the DNA vaccinated macaques displayed less bNAb activity. It was concluded that a trivalent mix of non-modified gp140 genes from rationally selected clinical isolates was, in this study, the best option to induce high and broad NAb in the rabbit model, but this optimization does not directly translate into similar responses in cynomolgus macaques.

Optimization of HIV-1 Envelope DNA Vaccine Candidates within Three Different Animal Models, Guinea Pigs, Rabbits and Cynomolgus Macaques

PubMed Central

Borggren, Marie; Vinner, Lasse; Andresen, Betina Skovgaard; Grevstad, Berit; Repits, Johanna; Melchers, Mark; Elvang, Tara Laura; Sanders, Rogier W; Martinon, Frédéric; Dereuddre-Bosquet, Nathalie; Bowles, Emma Joanne; Stewart-Jones, Guillaume; Biswas, Priscilla; Scarlatti, Gabriella; Jansson, Marianne; Heyndrickx, Leo; Le Grand, Roger; Fomsgaard, Anders

2013-01-01

HIV-1 DNA vaccines have many advantageous features. Evaluation of HIV-1 vaccine candidates often starts in small animal models before macaque and human trials. Here, we selected and optimized DNA vaccine candidates through systematic testing in rabbits for the induction of broadly neutralizing antibodies (bNAb). We compared three different animal models: guinea pigs, rabbits and cynomolgus macaques. Envelope genes from the prototype isolate HIV-1 Bx08 and two elite neutralizers were included. Codon-optimized genes, encoded secreted gp140 or membrane bound gp150, were modified for expression of stabilized soluble trimer gene products, and delivered individually or mixed. Specific IgG after repeated i.d. inoculations with electroporation confirmed in vivo expression and immunogenicity. Evaluations of rabbits and guinea pigs displayed similar results. The superior DNA construct in rabbits was a trivalent mix of non-modified codon-optimized gp140 envelope genes. Despite NAb responses with some potency and breadth in guinea pigs and rabbits, the DNA vaccinated macaques displayed less bNAb activity. It was concluded that a trivalent mix of non-modified gp140 genes from rationally selected clinical isolates was, in this study, the best option to induce high and broad NAb in the rabbit model, but this optimization does not directly translate into similar responses in cynomolgus macaques. PMID:26344115

3D Analysis of HCMV Induced-Nuclear Membrane Structures by FIB/SEM Tomography: Insight into an Unprecedented Membrane Morphology

PubMed Central

Villinger, Clarissa; Neusser, Gregor; Kranz, Christine; Walther, Paul; Mertens, Thomas

2015-01-01

We show that focused ion beam/scanning electron microscopy (FIB/SEM) tomography is an excellent method to analyze the three-dimensional structure of a fibroblast nucleus infected with human cytomegalovirus (HCMV). We found that the previously described infoldings of the inner nuclear membrane, which are unique among its kind, form an extremely complex network of membrane structures not predictable by previous two-dimensional studies. In all cases they contained further invaginations (2nd and 3rd order infoldings). Quantification revealed 5498 HCMV capsids within two nuclear segments, allowing an estimate of 15,000 to 30,000 capsids in the entire nucleus five days post infection. Only 0.8% proved to be enveloped capsids which were exclusively detected in 1st order infoldings (perinuclear space). Distribution of the capsids between 1st, 2nd and 3rd order infoldings is in complete agreement with the envelopment/de-envelopment model for egress of HCMV capsids from the nucleus and we confirm that capsid budding does occur at the large infoldings. Based on our results we propose the pushing membrane model: HCMV infection induces local disruption of the nuclear lamina and synthesis of new membrane material which is pushed into the nucleoplasm, forming complex membrane infoldings in a highly abundant manner, which then may be also used by nucleocapsids for budding. PMID:26556360

A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance

PubMed Central

Watterson, Daniel; Robinson, Jodie; Chappell, Keith J.; Butler, Mark S.; Edwards, David J.; Fry, Scott R.; Bermingham, Imogen M.; Cooper, Matthew A.; Young, Paul R.

2016-01-01

Fusion of the viral envelope with host cell membranes is an essential step in the life cycle of all enveloped viruses. Despite such a clear target for antiviral drug development, few anti-fusion drugs have progressed to market. One significant hurdle is the absence of a generic, high-throughput, reproducible fusion assay. Here we report that real time, label-free measurement of cellular electrical impedance can quantify cell-cell fusion mediated by either individually expressed recombinant viral fusion proteins, or native virus infection. We validated this approach for all three classes of viral fusion and demonstrated utility in quantifying fusion inhibition using antibodies and small molecule inhibitors specific for dengue virus and respiratory syncytial virus. PMID:26976324

Strategic Management Plan: The Business of Defense FY2014-2015

DTIC Science & Technology

2013-07-01

customer wait time ( CWT ) by three percent (from 14.1 days in FY2011 to 13.7 days in FY2012). The Army’s improvement was associated with receiving...rate from 86.2 percent in FY2011 to 87.1 percent in FY2012. The improvement to CWT and perfect order fulfillment means that the Warfighter receives

Emergence of FY*Anull in a Plasmodium vivax-endemic region of Papua New Guinea

PubMed Central

Zimmerman, Peter A.; Woolley, Ian; Masinde, Godfred L.; Miller, Stephanie M.; McNamara, David T.; Hazlett, Fred; Mgone, Charles S.; Alpers, Michael P.; Genton, Blaise; Boatin, B. A.; Kazura, James W.

1999-01-01

In Papua New Guinea (PNG), numerous blood group polymorphisms and hemoglobinopathies characterize the human population. Human genetic polymorphisms of this nature are common in malarious regions, and all four human malaria parasites are holoendemic below 1500 meters in PNG. At this elevation, a prominent condition characterizing Melanesians is α+-thalassemia. Interestingly, recent epidemiological surveys have demonstrated that α+-thalassemia is associated with increased susceptibility to uncomplicated malaria among young children. It is further proposed that α+-thalassemia may facilitate so-called “benign” Plasmodium vivax infection to act later in life as a “natural vaccine” against severe Plasmodium falciparum malaria. Here, in a P. vivax-endemic region of PNG where the resident Abelam-speaking population is characterized by a frequency of α+-thalassemia ≥0.98, we have discovered the mutation responsible for erythrocyte Duffy antigen-negativity (Fy[a−b−]) on the FY*A allele. In this study population there were 23 heterozygous and no homozygous individuals bearing this new allele (allele frequency, 23/1062 = 0.022). Flow cytometric analysis illustrated a 2-fold difference in erythroid-specific Fy-antigen expression between heterozygous (FY*A/FY*Anull) and homozygous (FY*A/FY*A) individuals, suggesting a gene-dosage effect. In further comparisons, we observed a higher prevalence of P. vivax infection in FY*A/FY*A (83/508 = 0.163) compared with FY*A/FY*Anull (2/23 = 0.087) individuals (odds ratio = 2.05, 95% confidence interval = 0.47–8.91). Emergence of FY*Anull in this population suggests that P. vivax is involved in selection of this erythroid polymorphism. This mutation would ultimately compromise α+-thalassemia/P. vivax-mediated protection against severe P. falciparum malaria. PMID:10570183

Alaska Department of Labor Administrative Services Division

Science.gov Websites

Sections Fiscal Research & Analysis Procurement Data Processing Budget Links State Employee Directory FY 2019 DOLWD Budget (Proposed) FY 2018 DOLWD Budget (Enacted) FY 2018 Indirect Cost Proposal FY 2016

Navy-Marine Corps Amphibious and Maritime Prepositioning Ship Programs: Background and Oversight Issues for Congress

DTIC Science & Technology

2005-08-02

called LHD-8 and is also procuring new LPD-17 class amphibious ships. A total of 12 LPD-17s were originally planned , but the FY2006-FY2011 Future Years...Defense Plan (FYDP) proposes reducing that figure to nine, with the final two to be procured in FY2006 and FY2007. The FY2006-FY2011 FYDP also calls...developments have caused the Navy to reconsider its plans for procuring amphibious ships and maritime prepositioning ships. One is a new concept of operations

Structures and Dynamics Division research and technology plans for FY 1894 and accomplishments for FY 1982

NASA Technical Reports Server (NTRS)

Bales, K. S.

1984-01-01

The Objectives, Expected Results, Approach, and Fiscal Year FY 1984 Milestones for the Structures and Dynamics Division's research programs are examined. The FY 1983 Accomplishments are presented where applicable.

Living donor liver transplantation in a recipient with anti-Fy(a) and Jk(a) antibodies.

PubMed

Kaibori, Masaki; Kishimoto, Yuji; Yanagida, Hidesuke; Yokoigawa, Norio; Yamamoto, Hidekazu; Kitade, Hiroaki; Fukuhara, Shirou; Egawa, Hiroto; Tanaka, Koichi; Kamiyama, Yasuo

2005-01-01

We report a case of a living donor liver transplantation using right lobe graft to a recipient having anti-Fy(a) and Jk(a) antibodies. The red blood cell (RBC) antigens of the donor were Fy (a+) and Jk (a-). We attempted to eliminate donor RBCs remaining in the graft by perfusing histidine-tryptophan-ketoglutarate. Further, Fy (a-)/Jk (a-) RBC concentrates were transfused during the operation. However, the anti-Fy(a) titer increased approximately 8-fold on the seventh postoperative day. On the same day, serum levels of transaminase and total bilirubin increased presumably due to acute cellular rejection. Steroid administration immediately reduced levels of transaminase, total bilirubin and anti-Fy(a) titer. The increase of anti-Fy(a) titer may be due to a secondary immune response to the donor's Fy(a) antigen on RBCs remaining in the graft.

Advanced evaporator technology progress report FY 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chamberlain, D.; Hutter, J.C.; Leonard, R.A.

1995-01-01

This report summarizes the work that was completed in FY 1992 on the program {open_quotes}Technology Development for Concentrating Process Streams.{close_quotes} The purpose of this program is to evaluate and develop evaporator technology for concentrating radioactive waste and product streams such as those generated by the TRUEX process. Concentrating these streams and minimizing the volume of waste generated can significantly reduce disposal costs; however, equipment to concentrate the streams and recycle the decontaminated condensates must be installed. LICON, Inc., is developing an evaporator that shows a great deal of potential for this application. In this report, concepts that need to bemore » incorporated into the design of an evaporator operated in a radioactive environment are discussed. These concepts include criticality safety, remote operation and maintenance, and materials of construction. Both solubility and vapor-liquid equilibrium data are needed to design an effective process for concentrating process streams. Therefore, literature surveys were completed and are summarized in this report. A model that is being developed to predict vapor phase compositions is described. A laboratory-scale evaporator was purchased and installed to study the evaporation process and to collect additional data. This unit is described in detail. Two new LICON evaporators are being designed for installation at Argonne-East in FY 1993 to process low-level radioactive waste generated throughout the laboratory. They will also provide operating data from a full-sized evaporator processing radioactive solutions. Details on these evaporators are included in this report.« less

Defense Energy Support Center Fact Book, Fiscal Year 1999, Twenty-Second Edition

DTIC Science & Technology

1999-01-01

numbers SOURCE: FACILITIES AND DISTRIBUTION MANAGEMENT COMMODITY BUSINESS UNIT 11 OCONUS COCO 10 8,717,850...GOCO 7 1,518,905 SOURCE: FACILITIES AND DISTRIBUTION MANAGEMENT COMMODITY BUSINESS UNIT DLA MANAGED STORAGE...FY 95 FY 96 FY 97 FY 98 FY 99 SOURCE: FACILITIES AND DISTRIBUTION MANAGEMENT COMMODITY BUSINESS UNIT 13 0 20 40 60 80 100 120 140 160 180 200 220

34 CFR 379.53 - What are the minimum performance levels for each compliance indicator?

Code of Federal Regulations, 2010 CFR

2010-07-01

... employment as follows: (i) No less than 50 percent during fiscal year (FY) 2001. (ii) No less than 51 percent during FY 2002. (iii) No less than 52 percent during FY 2003. (iv) No less than 54 percent during FY 2004. (v) No less than 55 percent during FY 2005 and any year thereafter. (2) Change in earnings. (i...

Building America Case Study: Field Trial of an Aerosol-Based Enclosure Sealing Technology, Clovis, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

This report presents the results from several demonstrations of a new method for sealing building envelope air leaks using an aerosol sealing process developed by the Western Cooling Efficiency Center at UC Davis. The process involves pressurizing a building while applying an aerosol sealant to the interior. As air escapes through leaks in the building envelope, the aerosol particles are transported to the leaks where they collect and form a seal that blocks the leak. Standard blower door technology is used to facilitate the building pressurization, which allows the installer to track the sealing progress during the installation and automaticallymore » verify the final building tightness. Each aerosol envelope sealing installation was performed after drywall was installed and taped, and the process did not appear to interrupt the construction schedule or interfere with other trades working in the homes. The labor needed to physically seal bulk air leaks in typical construction will not be replaced by this technology. However, this technology is capable of bringing the air leakage of a building that was built with standard construction techniques and HERS-verified sealing down to levels that would meet DOE Zero Energy Ready Homes program requirements. When a developer is striving to meet a tighter envelope leakage specification, this technology could greatly reduce the cost to achieve that goal by providing a simple and relatively low cost method for reducing the air leakage of a building envelope with little to no change in their common building practices.« less

The type 2 dengue virus envelope protein interacts with small ubiquitin-like modifier-1 (SUMO-1) conjugating enzyme 9 (Ubc9).

PubMed

Chiu, Mei-Wui; Shih, Hsiu-Ming; Yang, Tsung-Han; Yang, Yun-Liang

2007-05-01

Dengue viruses are mosquito-borne flaviviruses and may cause the life-threatening dengue hemorrhagic fever and dengue shock syndrome. Its envelope protein is responsible mainly for the virus attachment and entry to host cells. To identify the human cellular proteins interacting with the envelope protein of dengue virus serotype 2 inside host cells, we have performed a screening with the yeast-two-hybrid-based "Functional Yeast Array". Interestingly, the small ubiquitin-like modifier-1 conjugating enzyme 9 protein, modulating cellular processes such as those regulating signal transduction and cell growth, was one of the candidates interacting with the dengue virus envelope protein. With co-precipitation assay, we have demonstrated that it indeed could interact directly with the Ubc9 protein. Site-directed mutagenesis has demonstrated that Ubc9 might interact with the E protein via amino acid residues K51 and K241. Furthermore, immunofluorescence microscopy has shown that the DV2E-EGFP proteins tended to progress toward the nuclear membrane and co-localized with Flag-Ubc9 proteins around the nuclear membrane in the cytoplasmic side, and DV2E-EGFP also shifted the distribution of Flag-Ubc9 from evenly in the nucleus toward concentrating around the nuclear membrane in the nucleic side. In addition, over-expression of Ubc9 could reduce the plaque formation of the dengue virus in mammalian cells. This is the first report that DV envelope proteins can interact with the protein of sumoylation system and Ubc9 may involve in the host defense system to prevent virus propagation.

Duffy Blood Group Genotyping in Thai Blood Donors

PubMed Central

Intharanut, Kamphon; Siriphanthong, Kanokpol; Nathalang, Siriporn; Kupatawintu, Pawinee

2015-01-01

Background Duffy (FY) blood group genotyping is important in transfusion medicine because Duffy alloantibodies are associated with delayed hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. In this study, FY allele frequencies in Thai blood donors were determined by in-house PCR with sequence-specific primers (PCR-SSP), and the probability of obtaining compatible blood for alloimmunized patients was assessed. Methods Five hundred blood samples from Thai blood donors of the National Blood Centre, Thai Red Cross Society, were included. Only 200 samples were tested with anti-Fya and anti-Fyb using the gel technique. All 500 samples and four samples from a Guinea family with the Fy(a-b-) phenotype were genotyped by using PCR-SSP. Additionally, the probability of obtaining antigen-negative red blood cells (RBCs) for alloimmunized patients was calculated according to the estimated FY allele frequencies. Results The FY phenotyping and genotyping results were in 100% concordance. The allele frequencies of FY*A and FY*B in 500 central Thais were 0.962 (962/1,000) and 0.038 (38/1,000), respectively. Although the Fy(a-b-) phenotype was not observed in this study, FY*BES/FY*BES was identified by PCR-SSP in the Guinea family and was confirmed by DNA sequencing. Conclusions Our results confirm the high frequency of the FY*A allele in the Thai population, similar to that of Asian populations. At least 500 Thai blood donors are needed to obtain two units of antigen-negative RBCs for the Fy(a-b+) phenotype. PMID:26354350

Descriptive Summaries for Program Elements of the Research, Development, Test and Evaluation, Army Program FY 1981. Volume I.

DTIC Science & Technology

1980-01-01

S a 0= ae A CaAD i-oa IdO~a~a C34 A- C 4J g. aUaU -~ I " a~ .LIU f% d 0) v00- vdi I .4.sC. -C~ j -J 5 I la-us *- qwe s C,0AJ . .I M. 0 - 1. a 4a 4j t...4.48.4 a84 4 - H )4484 4 40 ’C > ~ Al 4804 0 96a c l m t " 0 48 .4 J 8 4 Is 1548ൈ . 4 4 84J08.4 4.. Q. 008 4.4w8DoG I = 48 (j.~ 4j2 a0 2048 .. 4 a

Water Remedial Investigation Report, Version 3.3. Volume 2

DTIC Science & Technology

1989-07-01

the Third Quarter FY 1987 water table contour map, S(Page 9 of 13) Water Level "KaU._ID LiaMAUan 26143 5175.9 26145 -999,9 27002 5095.3 27003 5098.0...26125 5146.9 26127 5164.6 26133 5147.0 26143 5175.9 4 26145 5140.9 ID 27001 5093.2 27002 5094.8 27003 51.08 -1 27004 B-105 20,43.7 27005 5094.2 27006...ML Po 1IM A- T .0 cO16 Folcm Iscale ’ 𔃾 IV*- C. [LA \\S Y4 6 It. ISO . 4:- 4~ 1A . 6 IAT sti ~~~~~ If*1 l H 44 - . C-99 0 S S 0 040 0 s HtHLm.01 0O

FY 2009-11 Operating Budget for Higher Education: Appropriations Committee Recommendations. Highlights

ERIC Educational Resources Information Center

Connecticut Department of Higher Education (NJ1), 2009

2009-01-01

This report explains that the General Fund budget: (1) calls for $1,565.4 million for the FY 2009-11 biennium, including $781.2 million in FY 2010 and $784.2 million in FY 2011; and (2) maintains the State's primary student financial aid programs at FY 2009 funding levels, with Connecticut Aid to Charter Oak funded at 80.0 percent of full funding…

77 FR 43301 - Medicaid Program; Disproportionate Share Hospital Allotments and Institutions for Mental Diseases...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-24

... increase in the CPI-U for the prior FY (0.0 percent). Column F FY 2010 TC MAP Exp. Incl. DSH. This column... including DSH expenditures. Column G FY 2010 TC MAP Exp. Net of DSH. This column contains the amount of the States' actual FY 2010 total computable DSH expenditures. Column H FY 2010 TC MAP Exp. Net of DSH. This...

Implementation of Branch-Point-Tolerant Wavefront Reconstructor for Strong Turbulence Compensation

DTIC Science & Technology

2012-06-14

Strehl ratio. Strehl ratio is defined as [38] S = ∫ ∞ −∞ ∫ ∞ −∞H( fx , fy) d fx d fy∫ ∞ −∞ ∫ ∞ −∞ Hdl( fx , fy) d fx d fy , (2.36) where H( fx , fy) is the...aberrated optical transfer function (OTF) [18] and Hdl( fx , fy) is the diffraction limited OTF. Both of these OTF’s are in terms of their spatial...frequencies fx and fy. There are several approximations to this form that better suit various applications or measurement techniques [25, 38]. For this

NSF- and SNARE-mediated membrane fusion is required for nuclear envelope formation and completion of nuclear pore complex assembly in Xenopus laevis egg extracts.

PubMed

Baur, Tina; Ramadan, Kristijan; Schlundt, Andreas; Kartenbeck, Jürgen; Meyer, Hemmo H

2007-08-15

Despite the progress in understanding nuclear envelope (NE) reformation after mitosis, it has remained unclear what drives the required membrane fusion and how exactly this is coordinated with nuclear pore complex (NPC) assembly. Here, we show that, like other intracellular fusion reactions, NE fusion in Xenopus laevis egg extracts is mediated by SNARE proteins that require activation by NSF. Antibodies against Xenopus NSF, depletion of NSF or the dominant-negative NSF(E329Q) variant specifically inhibited NE formation. Staging experiments further revealed that NSF was required until sealing of the envelope was completed. Moreover, excess exogenous alpha-SNAP that blocks SNARE function prevented membrane fusion and caused accumulation of non-flattened vesicles on the chromatin surface. Under these conditions, the nucleoporins Nup107 and gp210 were fully recruited, whereas assembly of FxFG-repeat-containing nucleoporins was blocked. Together, we define NSF- and SNARE-mediated membrane fusion events as essential steps during NE formation downstream of Nup107 recruitment, and upstream of membrane flattening and completion of NPC assembly.

Recent Funding | NREL

Science.gov Websites

Recent Funding Recent Funding The following table lists NREL's annual funding in millions of dollars per fiscal year. Fiscal Year Funding (in millions) FY17 458.0 FY16 427.4 FY15 357.0 FY14 360.3

75 FR 15686 - NOAA'S Office of Ocean Exploration and Research (OER) Strategic Plan FY 2011-FY 2015

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-30

...-01] NOAA'S Office of Ocean Exploration and Research (OER) Strategic Plan FY 2011-FY 2015 AGENCY: Office of Ocean Exploration and Research (OER), Oceanic and Atmospheric Research (OAR), National Oceanic... comment. [[Page 15687

Integration of academic and clinical performance-based faculty compensation plans: a system and its impact on an anaesthesiology department.

PubMed

Sakai, T; Hudson, M; Davis, P; Williams, J

2013-10-01

The current economic environment makes it difficult for academic institutions to maintain academic activities with necessary clinical coverage. Productivity-based faculty compensation is reported to improve clinical work output; however, the impact on academic productivity has not been fully described. An academic anaesthesiology department has used a comprehensive clinical and academic performance-based faculty compensation programme as fiscal year (FY) 2004. Faculty choosing to pursue an academic track can devote up to 80% of their time to non-clinical activities. Payment for this time is 'salary at risk', which is earned through a merit matrix system, which was newly developed to award points for various academic activities. Unclaimed portions of the salary at risk are absorbed into the department budget at the conclusion of the FY. Clinical activities are measured chiefly based on total hours of anaesthetic care. Academic full-time equivalents (FTEs) decreased by 12.0% in FY2005 (FTE of 16.0-14.1) but recovered to the baseline level in FY2006 and remained stable. Clinical FTE also decreased by 6.6% in FY2005 (FTE of 109.1-101.9), then increased in FY2006-FY2010. Increased clinical work output was observed among the clinical and academic faculty members. Each academic faculty member successfully earned their salary at risk in each FY. The annual number of peer-reviewed publications per academic FTE in original research increased from 0.31 (0.18) (FY2001-FY2003) to 0.73 (0.14) (FY2006-FY2011), P=0.024. Integration of clinical and academic performance-based faculty compensation systems is feasible and can be efficacious in a large academic anaesthesiology department.

Inpatient imaging utilization: trends of the past decade.

PubMed

Shinagare, Atul B; Ip, Ivan K; Abbett, Sarah K; Hanson, Richard; Seltzer, Steven E; Khorasani, Ramin

2014-03-01

We have previously reported inpatient imaging utilization trends at our institution from fiscal year (FY) 1984 through FY 2002. In this study, we assessed the trends in imaging utilization for inpatients from FY 2003 through FY 2012. In this institutional review board-approved retrospective study performed at a 793-bed tertiary care academic institution, we reviewed imaging utilization in adult inpatients from October 1, 2002, through September 30, 2012 (FY 2003 through FY 2012), and recorded the gross number of imaging studies coded by modality (conventional [radiography and fluoroscopy], ultrasound, nuclear medicine, CT, and MRI) and associated relative value units (RVUs). We used linear regression to assess trends in number of imaging studies and RVUs per case-mix-adjusted admission (CMAA). The total number of imaging studies, as well as the number of CT, nuclear medicine, and conventional studies adjusted for case mix, decreased (p=0.02, p=0.0006, p=0.0008, and p=0.001, respectively); CT per CMAA increased until FY 2009 and then decreased through FY 2012. Utilization of ultrasound and MRI did not change significantly (p=0.15 and p=0.22, respectively). Unadjusted global RVUs increased until FY 2009 and then showed a slight decrease through FY 2012 (p=0.04), whereas RVUs per CMAA did not change significantly (p=0.18). After decades of continued rise, imaging utilization for inpatients significantly decreased by most measures between FY 2009 and FY 2012. Future studies to evaluate the contribution of various factors to this decline, including efforts to reduce inappropriate use of imaging and concerns about potential harms of radiation exposure, may be helpful in optimizing imaging utilization and resource planning.

Analysis of Rotary Aircraft Alternatives for NATO SOF Organic Air Wing

DTIC Science & Technology

2012-06-01

analysis with an assumed program start in 2013 and an end in 2019 to determine the impact of short program duration on platform selection. D...FY12 GO\\ LR,~itl\\ l Sli LABOR H13 (J()VI R\\\\iFI\\TSE I AROR FY14 GOVLR\\\\iLI\\ I Sl:. LABOR H15 SI:.PO CSS FY II SII’O CSS FY 12 SEI’() CSS fY 13

Dual roles for FY in the regulation of FLC

PubMed Central

Feng, Wei

2011-01-01

In Arabidopsis, the flowering decision is determined by multiple pathways that integrate information from both endogenous signals and environmental cues. The genes of the autonomous pathway promote flowering by suppressing the expression of the floral repressor FLOWERING LOCUS C (FLC). Thus, autonomous-pathway mutants have elevated levels of FLC and are late flowering. Previous work has shown that two autonomous pathway proteins, FCA and FY, physically interact and this interaction is important in the repression of FLC. Recent work from our laboratory has shown that a hypomorphic allele of FY (fy-5) can cause earlier or later flowering, depending on the genetic background. These results suggest that FY has the potential to act as both an activator and a repressor of FLC. The FLC-activating activity of FY appears to be FCA-independent, as fy-5 causes earlier flowering in an fca-null background. Here we present a speculative model that reconciles these opposing phenotypes by proposing a dual role for FY in the regulation of flowering time. PMID:21633188

Dual roles for FY in the regulation of FLC.

PubMed

Feng, Wei; Michaels, Scott D

2011-05-01

In Arabidopsis, the flowering decision is determined by multiple pathways that integrate information from both endogenous signals and environmental cues. The genes of the autonomous pathway promote flowering by suppressing the expression of the floral repressor FLOWERING LOCUS C (FLC). Thus, autonomous-pathway mutants have elevated levels of FLC and are late flowering. Previous work has shown that two autonomous pathway proteins, FCA and FY, physically interact and this interaction is important in the repression of FLC. Recent work from our laboratory has shown that a hypomorphic allele of FY (fy-5) can cause earlier or later flowering, depending on the genetic background. These results suggest that FY has the potential to act as both an activator and a repressor of FLC. The FLC-activating activity of FY appears to be FCA-independent, as fy-5 causes earlier flowering in an fca-null background. Here we present a speculative model that reconciles these opposing phenotypes by proposing a dual role for FY in the regulation of flowering time.

Cementitious Barriers Partnership FY2013 End-Year Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flach, G. P.; Langton, C. A.; Burns, H. H.

2013-11-01

In FY2013, the Cementitious Barriers Partnership (CBP) demonstrated continued tangible progress toward fulfilling the objective of developing a set of software tools to improve understanding and prediction of the long-term structural, hydraulic and chemical performance of cementitious barriers used in nuclear applications. In November 2012, the CBP released “Version 1.0” of the CBP Software Toolbox, a suite of software for simulating reactive transport in cementitious materials and important degradation phenomena. In addition, the CBP completed development of new software for the “Version 2.0” Toolbox to be released in early FY2014 and demonstrated use of the Version 1.0 Toolbox on DOEmore » applications. The current primary software components in both Versions 1.0 and 2.0 are LeachXS/ORCHESTRA, STADIUM, and a GoldSim interface for probabilistic analysis of selected degradation scenarios. The CBP Software Toolbox Version 1.0 supports analysis of external sulfate attack (including damage mechanics), carbonation, and primary constituent leaching. Version 2.0 includes the additional analysis of chloride attack and dual regime flow and contaminant migration in fractured and non-fractured cementitious material. The LeachXS component embodies an extensive material property measurements database along with chemical speciation and reactive mass transport simulation cases with emphasis on leaching of major, trace and radionuclide constituents from cementitious materials used in DOE facilities, such as Saltstone (Savannah River) and Cast Stone (Hanford), tank closure grouts, and barrier concretes. STADIUM focuses on the physical and structural service life of materials and components based on chemical speciation and reactive mass transport of major cement constituents and aggressive species (e.g., chloride, sulfate, etc.). THAMES is a planned future CBP Toolbox component focused on simulation of the microstructure of cementitious materials and calculation of resultant hydraulic and constituent mass transfer parameters needed in modeling. Two CBP software demonstrations were conducted in FY2013, one to support the Saltstone Disposal Facility (SDF) at SRS and the other on a representative Hanford high-level waste tank. The CBP Toolbox demonstration on the SDF provided analysis on the most probable degradation mechanisms to the cementitious vault enclosure caused by sulfate and carbonation ingress. This analysis was documented and resulted in the issuance of a SDF Performance Assessment Special Analysis by Liquid Waste Operations this fiscal year. The two new software tools supporting chloride attack and dual-regime flow will provide additional degradation tools to better evaluate performance of DOE and commercial cementitious barriers. The CBP SRNL experimental program produced two patent applications and field data that will be used in the development and calibration of CBP software tools being developed in FY2014. The CBP software and simulation tools varies from other efforts in that all the tools are based upon specific and relevant experimental research of cementitious materials utilized in DOE applications. The CBP FY2013 program involved continuing research to improve and enhance the simulation tools as well as developing new tools that model other key degradation phenomena not addressed in Version 1.0. Also efforts to continue to verify the various simulation tools through laboratory experiments and analysis of field specimens are ongoing and will continue into FY2014 to quantify and reduce the uncertainty associated with performance assessments. This end-year report summarizes FY2013 software development efforts and the various experimental programs that are providing data for calibration and validation of the CBP developed software.« less

77 FR 9620 - Public Availability of FY 2011 Service Contract Inventories

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-17

... DEPARTMENT OF AGRICULTURE Public Availability of FY 2011 Service Contract Inventories AGENCY...: Notice of public availability of FY 2011 Service Contract inventories. SUMMARY: In accordance with... Agriculture is publishing this notice to advise the public of the availability of the FY 2011 Service Contract...

Annual Report 1984.

DTIC Science & Technology

1985-01-01

equipped with data collection platforms (DCP) by the end of FY 1985. (b) Communication. The DCP’s transmit the remote gaging station data over the...activated 78 platforms in FY 84 bringing the total number of operating stations to 85. Plans are to activate seven more platforms in FY 85. c. Acoustic... Platforms . The total program cost for FY 1984 is shown in Table VI-3. The total program cost for FY 1985 will be $172,720. (2) National Weather Service

Reporting and Disclosing Intragovernmental Transactions for the FY 1997 DOD Consolidated Financial Statements.

DTIC Science & Technology

1998-09-21

This report discusses the reporting and disclosing of intragovernmental transactions on FY 1997 DoD Component and FY 1997 DoD Consolidated Financial Statements . The...comply with the law, DoD prepared financial statements for the 16 reporting entities to be included in the FY 1997 DoD Consolidated Financial Statements . The...Consolidated Financial Statement. The overall audit objective was to determine whether the FY 1997 DoD Consolidated Financial Statements were presented

Cytotoxicity of Ultrasmall Gold Nanoparticles on Planktonic and Biofilm Encapsulated Gram-Positive Staphylococci.

PubMed

Boda, Sunil Kumar; Broda, Janine; Schiefer, Frank; Weber-Heynemann, Josefine; Hoss, Mareike; Simon, Ulrich; Basu, Bikramjit; Jahnen-Dechent, Willi

2015-07-01

The emergence of multidrug resistant bacteria, especially biofilm-associated Staphylococci, urgently requires novel antimicrobial agents. The antibacterial activity of ultrasmall gold nanoparticles (AuNPs) is tested against two gram positive: S. aureus and S. epidermidis and two gram negative: Escherichia coli and Pseudomonas aeruginosa strains. Ultrasmall AuNPs with core diameters of 0.8 and 1.4 nm and a triphenylphosphine-monosulfonate shell (Au0.8MS and Au1.4MS) both have minimum inhibitory concentration (MIC) and minimum bactericidal concentration of 25 × 10(-6) m [Au]. Disc agar diffusion test demonstrates greater bactericidal activity of the Au0.8MS nanoparticles over Au1.4MS. In contrast, thiol-stabilized AuNPs with a diameter of 1.9 nm (AuroVist) cause no significant toxicity in any of the bacterial strains. Ultrasmall AuNPs cause a near 5 log bacterial growth reduction in the first 5 h of exposure, and incomplete recovery after 21 h. Bacteria show marked membrane blebbing and lysis in biofilm-associated bacteria treated with ultrasmall AuNP. Importantly, a twofold MIC dosage of Au0.8MS and Au1.4MS each cause around 80%-90% reduction in the viability of Staphylococci enveloped in biofilms. Altogether, this study demonstrates potential therapeutic activity of ultrasmall AuNPs as an effective treatment option against staphylococcal infections. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

International Collaboration on Spent Fuel Disposition in Crystalline Media: FY17 Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Yifeng; Hadgu, Teklu; Kainina, Elena

Active participation in international R&D is crucial for achieving the Spent Fuel Waste Science & Technology (SFWST) long-term goals of conducting “experiments to fill data needs and confirm advanced modeling approaches” and of having a “robust modeling and experimental basis for evaluation of multiple disposal system options” (by 2020). DOE’s Office of Nuclear Energy (NE) has developed a strategic plan to advance cooperation with international partners. The international collaboration on the evaluation of crystalline disposal media at Sandia National Laboratories (SNL) in FY17 focused on the collaboration through the Development of Coupled Models and their Validation against Experiments (DECOVALEX-2019) project.more » The DECOVALEX project is an international research and model comparison collaboration, initiated in 1992, for advancing the understanding and modeling of coupled thermo-hydro-mechanical-chemical (THMC) processes in geological systems. SNL has been participating in three tasks of the DECOVALEX project: Task A. Modeling gas injection experiments (ENGINEER), Task C. Modeling groundwater recovery experiment in tunnel (GREET), and Task F. Fluid inclusion and movement in the tight rock (FINITO).« less

SAVY-4000 Surveillance and Life Extension Program Fiscal Year 2013 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stone, Timothy A.; Blair, Michael W.; Weis, Eric

2014-03-03

The Packaging Surveillance Program section of the DOE M441.1-1 /sup>1, Nuclear Material Packaging Manual (DOE, 2008) requires DOE contractors to “ensure that a surveillance program is established and implemented to ensure the nuclear material storage package continues to meet its design criteria.” In order to ensure continuing safe storage of nuclear material and the maximization of risk reduction, TA-55 has established a Surveillance Program to ensure storage container integrity for operations within its specified design life. The LANL SAVY-4000 Field Surveillance Plan2 defines the near-term field surveillance plan for SAVY-4000 containers as required by the Manual. A long-term surveillance planmore » will be established based on the results of the first several years of surveillance and the results of the lifetime extension studies as defined in the Accelerated Aging Plan3. This report details progress in positioning the Surveillance Program for successful implementation in FY14 and status of the Design Life Extension Program in terms of its implementation and data collection for FY13.« less

RELAP-7 Progress Report. FY-2015 Optimization Activities Summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berry, Ray Alden; Zou, Ling; Andrs, David

2015-09-01

This report summarily documents the optimization activities on RELAP-7 for FY-2015. It includes the migration from the analytical stiffened gas equation of state for both the vapor and liquid phases to accurate and efficient property evaluations for both equilibrium and metastable (nonequilibrium) states using the Spline-Based Table Look-up (SBTL) method with the IAPWS-95 properties for steam and water. It also includes the initiation of realistic closure models based, where appropriate, on the U.S. Nuclear Regulatory Commission’s TRACE code. It also describes an improved entropy viscosity numerical stabilization method for the nonequilibrium two-phase flow model of RELAP-7. For ease of presentationmore » to the reader, the nonequilibrium two-phase flow model used in RELAP-7 is briefly presented, though for detailed explanation the reader is referred to RELAP-7 Theory Manual [R.A. Berry, J.W. Peterson, H. Zhang, R.C. Martineau, H. Zhao, L. Zou, D. Andrs, “RELAP-7 Theory Manual,” Idaho National Laboratory INL/EXT-14-31366(rev. 1), February 2014].« less

Expanding the Envelope of UAS Certification: What it Takes to Type Certify a UAS for Precision Agricultural Spraying

NASA Technical Reports Server (NTRS)

Maddalon, J. M.; Hayhurst, K. J.; Neogi, N. A.; Verstynen, H. A.; Clothier, R. A.

2016-01-01

One of the key challenges to the development of a commercial Unmanned Air-craft System (UAS) market is the lack of explicit consideration of UAS in the current regulatory framework. Despite recent progress, additional steps are needed to enable broad UAS types and operational models. This paper discusses recent research that examines how a risk-based approach for safety might change the process and substance of airworthiness requirements for UAS. The project proposed risk-centric airworthiness requirements for a midsize un-manned rotorcraft used for agricultural spraying and also identified factors that may contribute to distinguishing safety risk among different UAS types and operational concepts. Lessons learned regarding how a risk-based approach can expand the envelope of UAS certification are discussed.

Research and technology plans for FY 1989 and accomplishments for FY 1988. [Structural Mechanics Division

NASA Technical Reports Server (NTRS)

Bales, Kay S.

1989-01-01

The Objectives, FY 1989 Plans, Approach, and FY 1989 Milestones for the Structural Mechanics Division's research programs are presented. Fiscal year 1988 Accomplishments are presented where applicable. This information is useful in program coordination with other governmental organizations in areas of mutual interest.

77 FR 5614 - Department of State FY11 Service Contract Inventory

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-03

... DEPARTMENT OF STATE [Public Notice 7785] Department of State FY11 Service Contract Inventory... Contract Inventory. SUMMARY: The Department of State has publically released its Service Contract Inventory for FY11 and its analysis of the FY10 inventory. They are available here: http://csm.state.gov...

76 FR 5559 - Public Availability of Department of Commerce FY 2010 Service Contract Inventory

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-01

...-01] Public Availability of Department of Commerce FY 2010 Service Contract Inventory AGENCY: Department of Commerce. ACTION: Notice of Public Availability of FY 2010 Service Contract Inventories... availability of the FY 2010 Service Contract inventory. This inventory provides information on service contract...

78 FR 12042 - Public Availability of Defense Nuclear Facilities Safety Board FY 2011 Service Contract Inventory...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-21

... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Public Availability of Defense Nuclear Facilities Safety Board FY 2011 Service Contract Inventory Analysis/FY 2012 Service Contract Inventory AGENCY: Defense Nuclear Facilities Safety Board (DNFSB). ACTION: Notice of Public Availability of FY 2011 Service Contract...

77 FR 7139 - Public Availability of Defense Nuclear Facilities Safety Board; FY 2010 Service Contract...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-10

... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Public Availability of Defense Nuclear Facilities Safety Board; FY 2010 Service Contract Inventory Analysis/FY 2011 Service Contract Inventory AGENCY: Defense Nuclear Facilities Safety Board (DNFSB). ACTION: Notice of Public Availability of FY 2010 Service Contract...

76 FR 34102 - Request for Comments-LSC Budget Request for FY 2013

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-10

... LEGAL SERVICES CORPORATION Request for Comments--LSC Budget Request for FY 2013 AGENCY: Legal Services Corporation. ACTION: Request for Comments--LSC Budget Request for FY 2013. SUMMARY: The Legal Services Corporation is beginning the process of developing its FY 2013 budget request to Congress and is...

75 FR 54389 - Request for Comments-LSC Budget Request for FY 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-07

... LEGAL SERVICES CORPORATION Request for Comments--LSC Budget Request for FY 2012 AGENCY: Legal Services Corporation. ACTION: Request for Comments--LSC Budget Request for FY 2012. SUMMARY: The Legal Services Corporation is beginning the process of developing its FY 2012 budget request to Congress and is...

25 CFR 39.1003 - Allotment exception for FY 1991.

Code of Federal Regulations, 2010 CFR

2010-04-01

... PROGRAM Administrative Cost Formula § 39.1003 Allotment exception for FY 1991. For FY 1991 only, the Director may reserve an amount equal to no more than one half of the funds received in FY 1990 by those... distributed in accordance with the formula in § 39.122. ...

25 CFR 39.1003 - Allotment exception for FY 1991.

Code of Federal Regulations, 2014 CFR

2014-04-01

... PROGRAM Administrative Cost Formula § 39.1003 Allotment exception for FY 1991. For FY 1991 only, the Director may reserve an amount equal to no more than one half of the funds received in FY 1990 by those... distributed in accordance with the formula in § 39.122. ...

25 CFR 39.1003 - Allotment exception for FY 1991.

Code of Federal Regulations, 2012 CFR

2012-04-01

... PROGRAM Administrative Cost Formula § 39.1003 Allotment exception for FY 1991. For FY 1991 only, the Director may reserve an amount equal to no more than one half of the funds received in FY 1990 by those... distributed in accordance with the formula in § 39.122. ...

25 CFR 39.1003 - Allotment exception for FY 1991.

Code of Federal Regulations, 2013 CFR

2013-04-01

... PROGRAM Administrative Cost Formula § 39.1003 Allotment exception for FY 1991. For FY 1991 only, the Director may reserve an amount equal to no more than one half of the funds received in FY 1990 by those... distributed in accordance with the formula in § 39.122. ...

25 CFR 39.1003 - Allotment exception for FY 1991.

Code of Federal Regulations, 2011 CFR

2011-04-01

... PROGRAM Administrative Cost Formula § 39.1003 Allotment exception for FY 1991. For FY 1991 only, the Director may reserve an amount equal to no more than one half of the funds received in FY 1990 by those... distributed in accordance with the formula in § 39.122. ...

77 FR 27801 - Request for Comments-LSC Budget Request for FY 2014

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-11

... LEGAL SERVICES CORPORATION Request for Comments--LSC Budget Request for FY 2014 AGENCY: Legal Services Corporation. ACTION: Request for Comments--LSC Budget Request for FY 2014. SUMMARY: The Legal Services Corporation is beginning the process of developing its FY 2014 budget request to Congress and is...

78 FR 13706 - Public Availability of FY 2011 Service Contract Inventory Analysis, FY 2012 Service Contract...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... analysis provides information on specific service contract actions that were analyzed as part of the FY... analysis at the following link: http://www.usitc.gov/procurement/ . FOR FURTHER INFORMATION CONTACT... INTERNATIONAL TRADE COMMISSION Public Availability of FY 2011 Service Contract Inventory Analysis...

77 FR 5519 - Public Availability of the Federal Communications Commission's FY 2011 Service Contract Inventory...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-03

... throughout the agency. The FY 2010 analysis provides additional information about the Federal Communications... FY 2011 Service Contract Inventory and FY 2010 Service Contract Inventory Analysis AGENCY: Federal Communications Commission. ACTION: Notice of public availability of service contract inventory and analysis...

Total Factor Productivity Growth, Technical Progress & Efficiency Change in Vietnam Coal Industry - Nonparametric Approach

NASA Astrophysics Data System (ADS)

Phuong, Vu Hung

2018-03-01

This research applies Data Envelopment Analysis (DEA) approach to analyze Total Factor Productivity (TFP) and efficiency changes in Vietnam coal mining industry from 2007 to 2013. The TFP of Vietnam coal mining companies decreased due to slow technological progress and unimproved efficiency. The decadence of technical efficiency in many enterprises proved that the coal mining industry has a large potential to increase productivity through technical efficiency improvement. Enhancing human resource training, technology and research & development investment could help the industry to improve efficiency and productivity in Vietnam coal mining industry.

[Research progress on ebola virus glycoprotein].

PubMed

Ding, Guo-Yong; Wang, Zhi-Yu; Gao, Lu; Jiang, Bao-Fa

2013-03-01

Ebola virus (EBOV) causes outbreaks of a highly lethal hemorrhagic fever in humans and there are no effective therapeutic or prophylactic treatments available. The glycoprotein (GP) of EBOV is a transmembrane envelope protein known to play multiple functions including virus attachment and entry, cell rounding and cytotoxicity, down-regulation of host surface proteins, and enhancement of virus assembly and budding. GP is the primary target of protective immunity and the key target for developing neutralizing antibodies. In this paper, the research progress on genetic structure, pathogenesis and immunogenicity of EBOV GP in the last 5 years is reviewed.

FY08 Engineering Research and Technology Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Minichino, C; McNichols, D

2009-02-24

This report summarizes the core research, development, and technology accomplishments in Lawrence Livermore National Laboratory's Engineering Directorate for FY2008. These efforts exemplify Engineering's more than 50-year history of developing and applying the technologies needed to support the Laboratory's national security missions. A partner in every major program and project at the Laboratory throughout its existence, Engineering has prepared for this role with a skilled workforce and technical resources developed through both internal and external venues. These accomplishments embody Engineering's mission: 'Enable program success today and ensure the Laboratory's vitality tomorrow.' Engineering's mission is carried out through basic research and technologymore » development. Research is the vehicle for creating competencies that are cutting-edge, or require discovery-class groundwork to be fully understood. Our technology efforts are discipline-oriented, preparing research breakthroughs for broader application to a variety of Laboratory needs. The term commonly used for technology-based projects is 'reduction to practice.' As we pursue this two-pronged approach, an enormous range of technological capabilities result. This report combines our work in research and technology into one volume, organized into thematic technical areas: Engineering Modeling and Simulation; Measurement Technologies; Micro/Nano-Devices and Structures; Engineering Systems for Knowledge and Inference; and Energy Manipulation. Our investments in these areas serve not only known programmatic requirements of today and tomorrow, but also anticipate the breakthrough engineering innovations that will be needed in the future.« less

Propagation of Multiwavelength Laser Radiation through Atmospheric Turbulence

DTIC Science & Technology

1974-11-01

be applied. The fundamental determining factor in data spread is shown to be the two-point correlation of he microthermal envelope fluctuations...Engineer li / Jt M^ ^^w Summary This report reviews in detail our progress on understanding the short-term statistics of microthermal turbulence...fluctuations and optical/ infrared scintillations, and their interrelationship. A complete analytical understanding of microthermal and scintillation

Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals.

PubMed

Álvarez-Fernández, Mónica; Sánchez-Martínez, Ruth; Sanz-Castillo, Belén; Gan, Pei Pei; Sanz-Flores, María; Trakala, Marianna; Ruiz-Torres, Miguel; Lorca, Thierry; Castro, Anna; Malumbres, Marcos

2013-10-22

Greatwall is a protein kinase involved in the inhibition of protein phosphatase 2 (PP2A)-B55 complexes to maintain the mitotic state. Although its biochemical activity has been deeply characterized in Xenopus, its specific relevance during the progression of mitosis is not fully understood. By using a conditional knockout of the mouse ortholog, Mastl, we show here that mammalian Greatwall is essential for mouse embryonic development and cell cycle progression. Yet, Greatwall-null cells enter into mitosis with normal kinetics. However, these cells display mitotic collapse after nuclear envelope breakdown (NEB) characterized by defective chromosome condensation and prometaphase arrest. Intriguingly, Greatwall is exported from the nucleus to the cytoplasm in a CRM1-dependent manner before NEB. This export occurs after the nuclear import of cyclin B-Cdk1 complexes, requires the kinase activity of Greatwall, and is mediated by Cdk-, but not Polo-like kinase 1-dependent phosphorylation. The mitotic collapse observed in Greatwall-deficient cells is partially rescued after concomitant depletion of B55 regulatory subunits, which are mostly cytoplasmic before NEB. These data suggest that Greatwall is an essential protein in mammals required to prevent mitotic collapse after NEB.

Research and Technology Objectives and Plans Summary (RTOPS)

NASA Technical Reports Server (NTRS)

1992-01-01

This publication represents the NASA research and technology program for FY92. It is a compilation of the Summary portions of each of the RTOP's (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP Summary is designed to facilitate communication and coordination among concerned technical personnel in government, in industry, and in universities. The first section containing citations and abstracts of the RTOP's is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP Number.

Research and technology objectives and plans: Summary fiscal year 1991

NASA Technical Reports Server (NTRS)

1991-01-01

This publication represents the NASA research and technology program for FY 1991. It is a compilation of the Summary portions of each of the RTOP's (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP Summary is designed to facilitate communication and coordination among concerned technical personnel in government, industry, and in universities. The first section contains citations and abstracts of the RTOP's and is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP Number.

High-Speed Research: Sonic Boom, volume 1

NASA Technical Reports Server (NTRS)

Darden, Christine M. (Compiler)

1992-01-01

A High-Speed Sonic Boom Workshop was held at LaRC of Feb. 25-27, 1992. The purpose was to make presentations on current research activities and accomplishments and to assess progress in the area of sonic boom since the program was initiated in FY-90. Twenty-nine papers were presented during the 2-1/2 day workshop. Attendees included representatives from academia, industry, and government who are actively involved in sonic-boom research. Volume 1 contains papers related to atmospheric effects on the sonic-boom signature during propagation and on acceptability studies.

Lithium Battery Safety/Cell-to-Cell Failure Project FY14 Progress Report

DTIC Science & Technology

2015-03-06

Delacourt, “Thermal modeling of a cylindrical LiFePO4 /graphite lithium-ion battery.” J. Power Sources 195 (2010) 2961- 2968. 18. T. B. Bandhauer, S...Ren, J. Xie, H. He and F. Xu, “Failure study of commercial LiFePO4 cells in over-discharge conditions using electrochemical impedance spectroscopy...graphite/ LiFePO4 cell.” J. Power Sources 208 (2012) 296-305. 61. N. S. Spinner, C. T. Love, S. G. Tuttle, K. Swider-Lyons and S. L. Rose-Pehrsson

Research and Technology Objectives and Plans Summary (RTOPS)

NASA Technical Reports Server (NTRS)

1993-01-01

This publication represents the NASA research and technology program for FY-93. It is a compilation of the Summary portions of each of the RTOP's (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP Summary is designed to facilitate communication and coordination among concerned technical personnel in government, in industry, and in universities. The first section containing citations and abstracts of the RTOP's is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP Number.

US Army Institute of Surgical Research Annual Research Progress Report FY 1981.

DTIC Science & Technology

1981-10-01

injury in seven, multiple lacerations in nine, eye injuries in 13 and fractures in six patients. STATISTICAL RESUME DURING CALENDAR YEAR 1980 Two hundred...L, Elings VB, Lewis FR: Thermal-dye lung water measurements: effects of edema and embolization . J Surg Res 26: 504-12, 1979 47. Brigham K, Woolverton...U11 ’"NtOI to U.91. Starting to 1972, a small nuber of atrMAis esm ta 0.6252 fat IsAibItton. swmvers this mweber has net luateaed.it has rooag from

Administrative Information Systems Plan for FY89

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1988-11-01

The Administrative Information Systems (AIS) Plan was developed to prioritize, track, and control the cost of AIS activities. This annually published plan, in conjunction with quarterly status reports, measures projected AIS activities and progress. The AIS Plan and quarterly reporting are administered jointly by the Director of Computing and an Organization 30 director. Priority development projects are clearly defined and closely managed efforts that consume significant resources. Directorate supplementals describe other AIS activity within each directorate, which may include: production support; technical support; development activity; and other AIS effort.

FY2014 Electric Drive Technologies Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The Electric Drive Technologies research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research is focused on developing power electronics (PE), electric motor, and traction drive system (TDS) technologies that will reduce system cost and improve their efficiency in transforming battery energy to useful work. The R&D is also aimed at better understanding and improving how various components of tomorrow’s automobiles will function as a unified system to improve fuel efficiency.

FY2012 Advanced Power Electronics and Electric Motors Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, Susan A.

The Advanced Power Electronics and Electric Motors (APEEM) program within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies now under development. Research is focused on developing revolutionary new power electronics (PE), electric motor (EM), thermal management, and traction drive system technologies that will leapfrog current on-the-road technologies. The research and development is also aimed at achieving a greater understanding of and improvements in the way the various new components of tomorrow's automobiles will function as a unified system to improve fuel efficiency.

FY2016 Electric Drive Technologies Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Electric Drive Technologies research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research is focused on developing power electronics (PE), electric motor, and traction drive system (TDS) technologies that will reduce system cost and improve their efficiency in transforming battery energy to useful work. The R&D is also aimed at better understanding and improving how various components of tomorrow’s automobiles will function as a unified system to improve fuel efficiency.

FY2015 Electric Drive Technologies Annual Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Electric Drive Technologies research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research is focused on developing power electronics (PE), electric motor, and traction drive system (TDS) technologies that will reduce system cost and improve their efficiency in transforming battery energy to useful work. The R&D is also aimed at better understanding and improving how various components of tomorrow’s automobiles will function as a unified system to improve fuel efficiency.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Campbell, J.A.; Clauss, S.A.; Grant, K.E.

The objectives of this task are to develop and document extraction and analysis methods for organics in waste tanks, and to extend these methods to the analysis of actual core samples to support the Waste Tank organic Safety Program. This report documents progress at Pacific Northwest Laboratory (a) during FY 1994 on methods development, the analysis of waste from Tank 241-C-103 (Tank C-103) and T-111, and the transfer of documented, developed analytical methods to personnel in the Analytical Chemistry Laboratory (ACL) and 222-S laboratory. This report is intended as an annual report, not a completed work.

Research and Technology Objectives and Plans Summary (RTOPS)

NASA Technical Reports Server (NTRS)

1988-01-01

This publication represents the NASA research and technology program for FY88. It is a compilation of the Summary portions of each of the RTOPs (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP Summary is designed to facilitate communication and coordination among concerned technical personnel in government, in industry, and in universities. The first section containing citations and abstracts of the RTOPs is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP Number.

Research and Technology Objectives and Plans Summary (RTOPS)

NASA Technical Reports Server (NTRS)

1989-01-01

This publication represents the NASA research and technology program for FY89. It is a compilation of the Summary portions of each of the RTOPs (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP Summary is designed to facilitate communication and coordination among concerned technical personnel in government, in industry, and in universities. The first section containing citations and abstracts of the RTOPs is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP Number.

Research and Technology Objectives and Plans Summary (RTOPS)

NASA Technical Reports Server (NTRS)

1985-01-01

This publication represents the NASA research and technology program for FY 1985. It is a compilation of the Summary portions of each of the RTOPs (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP summary is designed to facilitate communication and coordination among concerned technical personnel in government, in industry, and in universities. The first section containing citations and abstracts of the RTOPs is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP number.

Research and Technology Objectives and Plans Summary (RTOPS)

NASA Technical Reports Server (NTRS)

1987-01-01

This publication represents the NASA research and technology program for FY87. It is a compilation of the Summary portions of each of the RTOPs (Research and Technology Objectives and Plans) used for management review and control of research currently in progress throughout NASA. The RTOP Summary is designed to facilitate communication and coordination among concerned technical personnel in government, in industry, and in universities. The first section containing citations and abstracts of the RTOPs is followed by four indexes: Subject, Technical Monitor, Responsible NASA Organization, and RTOP Number.

FY2010 Annual Progress Report for Advanced Power Electronics and Electric Motors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, Susan A.

2011-01-01

The Advanced Power Electronics and Electric Machines (APEEM) subprogram within the Vehicle Technologies Program provides support and guidance for many cutting-edge automotive technologies now under development. Research is focused on developing revolutionary new power electronics (PE) and electric motor technologies that will leapfrog current on-the-road technologies. The research and development (R&D) is also aimed at achieving a greater understanding of and improvements in the way the various new components of tomorrow’s automobiles will function as a unified system to improve fuel efficiency.

Status of Progress Made Toward Safety Analysis and Technical Site Evaluations for DOE Managed HLW and SNF.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sevougian, S. David; Stein, Emily; Gross, Michael B

The Spent Fuel and Waste Science and Technology (SFWST) Campaign of the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE) is conducting research and development (R&D) on generic deep geologic disposal systems (i.e., repositories). This report describes specific activities in FY 2016 associated with the development of a Defense Waste Repository (DWR)a for the permanent disposal of a portion of the HLW and SNF derived from national defense and research and development (R&D) activities of the DOE.

Annual Progress Report on the Development of Waste Tank Leak Monitoring and Detection and Mitigation Activities in Support of M-45-08

DOE Office of Scientific and Technical Information (OSTI.GOV)

DEFIGH PRICE, C.

2000-09-25

Milestone M-45-09E of the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement or TPA) [TPA 1996] requires submittal of an annual progress report on the development of waste tank leak detection, monitoring, and mitigation (LDMM) activities associated with the retrieval of waste from single-shell tanks (SSTs). This report details progress for fiscal year 2000, building on the current LDMM strategy and including discussion of technologies, applications, cost, schedule, and technical data. The report also includes discussion of demonstrations conducted and recommendations for additional testing. Tri-Party Agreement Milestones M-45-08A and M-45-08B required design and demonstration of LDMM systems for initialmore » retrieval of SST waste. These specific milestones have recently been deleted as part of the M-45-00A change package. Future LDMM development work has been incorporated into specific technology demonstration milestones and SST waste retrieval milestones in the M-45-03 and M-45-05 milestone series.« less

Management of pregnancies complicated by anti-Fy(a) alloimmunization.

PubMed

Hughes, Laura H; Rossi, Karen Q; Krugh, David W; O'Shaughnessy, Richard W

2007-10-01

The objective was to evaluate the management and outcome of patients with anti-Fy(a) at the Ohio State University. A database search for patients with pregnancies complicated only by anti-Fy(a) from 1959 to 2004. Collected information included maternal testing, fetal therapy, and neonatal outcomes. The final data set included 18 pregnancies in 15 women where anti-Fy(a) was the only maternal alloantibody present and the fetus was Fy(a) antigen-positive. Maternal antibody titers of at least 32 and optical density at 450 nm values in modified Liley Zone IIB or III identified all fetuses or neonates with significant hemolytic disease (2/18, 11%). No fetuses had hydrops, and there were no deaths attributed to hemolytic disease of the fetus and newborn. Anti-Fy(a) has the potential to lead to significant fetal hemolysis. Management guidelines developed for D sensitization are appropriate for pregnancies complicated by anti-Fy(a) alloimmunization.

76 FR 5589 - Public Availability of Federal Election Commission, Procurement Division FY 2010 Service Contract...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-01

... Division FY 2010 Service Contract Inventory AGENCY: Federal Election Commission. ACTION: Notice of public availability of FY 2010 Service Contract Inventories. SUMMARY: In accordance with Section 743 of Division C of... this notice to advise the public of the availability of the FY 2010 Service Contract inventory. This...

77 FR 50542 - Public Availability of the Securities and Exchange Commission's FY 2011 Service Contract Inventory

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-21

... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-67663] Public Availability of the Securities and Exchange Commission's FY 2011 Service Contract Inventory AGENCY: U.S. Securities and Exchange... Inventory Analysis for FY2010 provides information based on the FY 2010 Inventory. The SEC has posted its...

76 FR 56322 - Fisheries of the Northeastern United States; Northeast (NE) Multispecies Fishery; Framework...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-13

... common pool vessels for FY 2011 due to overages of FY 2010 catch levels. This measure will help prevent.... SUPPLEMENTARY INFORMATION: FY 2011 Differential DAS Counting for Common Pool Vessels Based on preliminary FY 2010 common pool catch information available in February 2011, NMFS previously estimated that common...

A principal component analysis of the relationship between the external body shape and internal skeleton for the upper body.

PubMed

Nerot, A; Skalli, W; Wang, X

2016-10-03

Recent progress in 3D scanning technologies allows easy access to 3D human body envelope. To create personalized human models with an articulated linkage for realistic re-posturing and motion analyses, an accurate estimation of internal skeleton points, including joint centers, from the external envelope is required. For this research project, 3D reconstructions of both internal skeleton and external envelope from low dose biplanar X-rays of 40 male adults were obtained. Using principal component analysis technique (PCA), a low-dimensional dataset was used to predict internal points of the upper body from the trunk envelope. A least squares method was used to find PC scores that fit the PCA-based model to the envelope of a new subject. To validate the proposed approach, estimated internal points were evaluated using a leave-one-out (LOO) procedure, i.e. successively considering each individual from our dataset as an extra-subject. In addition, different methods were proposed to reduce the variability in data and improve the performance of the PCA-based prediction. The best method was considered as the one providing the smallest errors between estimated and reference internal points with an average error of 8.3mm anterior-posteriorly, 6.7mm laterally and 6.5mm vertically. As the proposed approach relies on few or no bony landmarks, it could be easily applicable and generalizable to surface scans from any devices. Combined with automatic body scanning techniques, this study could potentially constitute a new step towards automatic generation of external/internal subject-specific manikins. Copyright © 2016 Elsevier Ltd. All rights reserved.

Envelope co-receptor tropism, drug resistance, and viral evolution among subtype C HIV-1 infected individuals receiving non-suppressive antiretroviral therapy

PubMed Central

Kassaye, Seble; Johnston, Elizabeth; McColgan, Bryan; Kantor, Rami; Zijenah, Lynn; Katzenstein, David

2009-01-01

In resource-constrained settings, antiretroviral treatment (ART) is often continued based on clinical and CD4 responses, without virologic monitoring. ART with incomplete viral suppression was assessed in 27 subjects with subtype C HIV-1 by measuring plasma HIV-1 RNA, drug resistance, viral tropism, and evolution in polymerase (pol) and envelope (env) genes. The association between these viral parameters and CD4 cell change over time was analyzed using linear regression models. Increased area under the curve of HIV-1 RNA replication was a predictor of lower CD4 cell gains (p <0.007), while less drug resistance measured as a genotypic susceptibility score (GSS) (p=0.065), and lower rates of evolution in pol and env genes (p= 0.08 and 0.097, respectively) measured as genetic distance were modestly associated with increasing CD4 cell counts. Evolution of pol and env were correlated (R2 = 0.48, p=0.005), however, greater evolution was identified in env vs. pol (p <0.05). CXCR4-usage (X4) was detected in 14/27 (52%) but no differences in CD4 cell change or plasma viremia were associated with X4-usage. Among subtype C HIV-1 infected patients in Zimbabwe receiving incompletely suppressive ART, higher virus replication and lower CD4 cell gains were associated with drug resistance and evolution of polymerase and envelope. PMID:19295330

A uniform method for the simultaneous blood group phenotyping of Fya , Fyb , Jka , Jkb , S, s̅, P1, k applying lateral-flow technique.

PubMed

Caesar, A; Meyer, S; Trost, N; Neuenschwander, K; Geisen, C; Frey, B M; Gassner, C; Schwind, P

2018-02-01

A lateral flow assay for simultaneous blood group typing of ABO, RhD, C, E, c, e, Cw and K with stable end-point and without centrifugation is in routine use since several years (MDmulticard ® ). The typing of extended phenotype parameters belonging to the Duffy, Kidd, MNSs blood group systems and others, however, has not yet been demonstrated for this technique. Reliable detection of Fy x , a weak Fy b phenotype with a pronounced quantitative reduction of the number of Fy b antigens on the erythrocyte surface, remains a weakness of current serological blood grouping techniques. The performance characteristics of the following reagents were evaluated in donor and patient samples in lateral flow technology (MDmulticard ® ): Anti-Fy a , -Fy b , -Jk a , -Jk b , -S, -s̅, -P1 and -k. The sensitivity to detect Fy x was in addition evaluated with Fy x positive samples, which had been preselected by MALDI-TOF MS-based genotyping. All results obtained with the MDmulticard ® were in full accordance with those of the CE-certified reference products for all the eight reagent formulations used: Anti-Fy a , -Fy b , -Jk a , -Jk b , -S, -s̅, -P1 and -k. Also, all Fy x phenotypes of the selected population of 93 positive samples, originally identified by MALDI-TOF MS-based genotyping, were reliably detected by the lateral flow assay. Extended phenotype blood group parameters, including the serologically challenging Fy x phenotype, can be determined simultaneously, rapidly and accurately using the lateral flow (MDmulticard ® ) technology, even in cases when IgG class antibodies are the only source of diagnostic antibodies. © 2017 International Society of Blood Transfusion.

NIH and NCI grant-related changes during fiscal years 2014 and 2015

NASA Astrophysics Data System (ADS)

Wong, Rosemary S. L.

2015-03-01

The 2014 fiscal year (FY) continued to be a challenging one for all federal agencies despite the many Congressional strategies proposed to address the U.S. budget deficit. The Bipartisan Budget Act of 2013 passed by the House and Senate in December 2013 approved a two-year spending bill which cancelled the FY2014 and FY2015 required sequestration cuts (i.e., 4-5% National Institute of Health (NIH)/National Cancer Institute (NCI) budget reduction initiated on March 1, 2013), but extended the sequestration period through FY2023. This bill passage helped minimize any further budget reductions and resulted in a final FY2014 NIH budget of 29.9 billion and a NCI budget of 4.9 billion. Both NIH and NCI worked hard to maintain awarding the same number of NIH/NCI investigator-initiated R01 and exploratory R21 grants funded in FY2014 and similar to the level seen in FY2013 and previous years (see Tables 1 and 2). Since Congress only recently passed the 2015 spending bill in December 16, 2014, the final NIH and NCI budget appropriations for FY2015 remains unknown at this time and most likely will be similar to the FY2014 budget level. The NCI overall success and funding rates for unsolicited investigator-initiated R01 applications remained at 15%, while the success rate for exploratory R21 applications was 12% in FY2014 with similar rates seen in FY2013 (see Tables 1 and 2). The success rate for biomedical research applications in the Photodynamic Therapy and laser research field will be provided for the past few years. NIH provides numerous resources to help inform the extramural biomedical research community of new and current grant applicants about new grant policy changes and the grant submission and review processes.

Compensation in academic medicine: progress toward gender equity.

PubMed

Wright, Anne L; Ryan, Kenneth; St Germain, Patricia; Schwindt, Leslie; Sager, Rebecca; Reed, Kathryn L

2007-10-01

Studies have documented substantial salary disparities between women and men in academic medicine. While various strategies have been proposed to increase equity, to our knowledge, no interventions have been evaluated. This paper aims to assess the effect of an identity-conscious intervention on salary equity. This study shows comparison of adjusted annual salaries for women and men before and after an intervention. We studied full time faculty employed in FY00 (n = 393) and FY04 (n = 462) in one College of Medicine. Compensation data were obtained from personnel databases for women and men, and adjusted for predictors. After verification of data accuracy by departments, comparable individuals within the same department who had different salaries were identified. The Dean discussed apparent disparities with department heads, and salaries were adjusted. Total adjusted annualized salaries were compared for men and women for the year the project began and the year after the intervention using multivariate models. Female faculty members' salaries were also considered as a percent of male faculty members' salaries. Twenty-one potential salary disparities were identified. Eight women received equity adjustments to their salaries, with the average increase being $17,323. Adjusted salaries for women as a percent of salary for men increased from 89.4% before the intervention to 93.5% after the intervention. Disparities in compensation were no longer significant in FY2004 in basic science departments, where women were paid 97.6% of what men were paid. This study shows that gender disparities in compensation can be reduced through careful documentation, identification of comparable individuals paid different salaries, and commitment from leadership to hold the appropriate person accountable.

Size and characteristics of the biomedical research workforce associated with U.S. National Institutes of Health extramural grants

PubMed Central

Pool, Lindsay R.; Wagner, Robin M.; Scott, Lindsey L.; RoyChowdhury, Deepshikha; Berhane, Rediet; Wu, Charles; Pearson, Katrina; Sutton, Jennifer A.; Schaffer, Walter T.

2016-01-01

The U.S. National Institutes of Health (NIH) annually invests approximately $22 billion in biomedical research through its extramural grant programs. Since fiscal year (FY) 2010, all persons involved in research during the previous project year have been required to be listed on the annual grant progress report. These new data have enabled the production of the first-ever census of the NIH-funded extramural research workforce. Data were extracted from All Personnel Reports submitted for NIH grants funded in FY 2009, including position title, months of effort, academic degrees obtained, and personal identifiers. Data were de-duplicated to determine a unique person count. Person-years of effort (PYE) on NIH grants were computed. In FY 2009, NIH funded 50,885 grant projects, which created 313,049 full- and part-time positions spanning all job functions involved in biomedical research. These positions were staffed by 247,457 people at 2,604 institutions. These persons devoted 121,465 PYE to NIH grant-supported research. Research project grants each supported 6 full- or part-time positions, on average. Over 20% of positions were occupied by postdoctoral researchers and graduate and undergraduate students. These baseline data were used to project workforce estimates for FYs 2010–2014 and will serve as a foundation for future research.—Pool, L. R., Wagner, R. M., Scott, L. L., RoyChowdhury, D., Berhane, R., Wu, C., Pearson, K., Sutton, J. A., Schaffer, W. T. Size and characteristics of the biomedical research workforce associated with U.S. National Institutes of Health extramural grants. PMID:26625903

Ignition and Inertial Confinement Fusion at The National Ignition Facility

NASA Astrophysics Data System (ADS)

Moses, Edward I.

2016-10-01

The National Ignition Facility (NIF), the world's largest and most powerful laser system for inertial confinement fusion (ICF) and for studying high-energy-density (HED) science, is now operational at Lawrence Livermore National Laboratory (LLNL). The NIF is now conducting experiments to commission the laser drive, the hohlraum and the capsule and to develop the infrastructure needed to begin the first ignition experiments in FY 2010. Demonstration of ignition and thermonuclear bum in the laboratory is a major NIF goal. NIF will achieve this by concentrating the energy from the 192 beams into a mm3-sized target and igniting a deuterium-tritium mix, liberating more energy than is required to initiate the fusion reaction. NIP's ignition program is a national effort managed via the National Ignition Campaign (NIC). The NIC has two major goals: execution of DT ignition experiments starting in FY20l0 with the goal of demonstrating ignition and a reliable, repeatable ignition platform by the conclusion of the NIC at the end of FY2012. The NIC will also develop the infrastructure and the processes required to operate NIF as a national user facility. The achievement of ignition at NIF will demonstrate the scientific feasibility of ICF and focus worldwide attention on laser fusion as a viable energy option. A laser fusion-based energy concept that builds on NIF, known as LIFE (Laser Inertial Fusion Energy), is currently under development. LIFE is inherently safe and can provide a global carbon-free energy generation solution in the 21st century. This paper describes recent progress on NIF, NIC, and the LIFE concept.

Effects of Energy Needs and Expenditures on U.S. Public Schools. Statistical Analysis Report.

ERIC Educational Resources Information Center

Smith, Timothy; Porch, Rebecca; Farris, Elizabeth; Fowler, William

This report provides national estimates on energy needs and expenditures of U.S. public school districts. The survey provides estimates of Fiscal Year (FY) 2000 energy expenditures, FY 2001 energy budgets and expenditures, and FY 2002 energy budgets; methods used to cover energy budget shortfalls in FY 2001; and possible reasons for those…