Environmental Studies and Utilitarian Ethics

ERIC Educational Resources Information Center

Wolff, Brian G.

2008-01-01

Environmental ethicists have focused much attention on the limits of utilitarianism and have generally defined "environmental ethics" in a manner that treats utilitarian environmental ethics as an oxymoron. This is unfortunate because utilitarian ethics can support strong environmental policies, and environmental ethicists have not yet produced a…

Environmental Studies and Utilitarian Ethics

ERIC Educational Resources Information Center

Wolff, Brian G.

2009-01-01

Environmental ethicists have focused much attention on the limits of utilitarianism and have generally defined "environmental ethics" in a manner that treats utilitarian environmental ethics as an oxymoron. This is unfortunate because utilitarian ethics can support strong environmental policies, and environmental ethicists have not yet produced a…

Electron spin resonance as a high sensitivity technique for environmental magnetism: determination of contamination in carbonate sediments

NASA Astrophysics Data System (ADS)

Crook, Nigel P.; Hoon, Stephen R.; Taylor, Kevin G.; Perry, Chris T.

2002-05-01

This study investigates the application of high sensitivity electron spin resonance (ESR) to environmental magnetism in conjunction with the more conventional techniques of magnetic susceptibility, vibrating sample magnetometry (VSM) and chemical compositional analysis. Using these techniques we have studied carbonate sediment samples from Discovery Bay, Jamaica, which has been impacted to varying degrees by a bauxite loading facility. The carbonate sediment samples contain magnetic minerals ranging from moderate to low concentrations. The ESR spectra for all sites essentially contain three components. First, a six-line spectra centred around g = 2 resulting from Mn2+ ions within a carbonate matrix; second a g = 4.3 signal from isolated Fe3+ ions incorporated as impurities within minerals such as gibbsite, kaolinite or quartz; third a ferrimagnetic resonance with a maxima at 230 mT resulting from the ferrimagnetic minerals present within the bauxite contamination. Depending upon the location of the sites within the embayment these signals vary in their relative amplitude in a systematic manner related to the degree of bauxite input. Analysis of the ESR spectral components reveals linear relationships between the amplitude of the Mn2+ and ferrimagnetic signals and total Mn and Fe concentrations. To assist in determining the origin of the ESR signals coral and bauxite reference samples were employed. Coral representative of the matrix of the sediment was taken remote from the bauxite loading facility whilst pure bauxite was collected from nearby mining facilities. We find ESR to be a very sensitive technique particularly appropriate to magnetic analysis of ferri- and para-magnetic components within environmental samples otherwise dominated by diamagnetic (carbonate) minerals. When employing typical sample masses of 200 mg the practical detection limit of ESR to ferri- and para-magnetic minerals within a diamagnetic carbonate matrix is of the order of 1 ppm and 1 ppb respectively, approximately 102 and 105 times the sensitivity achievable employing the VSM in our laboratory.

Biodegradable Cellulose-based Hydrogels: Design and Applications

PubMed Central

Sannino, Alessandro; Demitri, Christian; Madaghiele, Marta

2009-01-01

Hydrogels are macromolecular networks able to absorb and release water solutions in a reversible manner, in response to specific environmental stimuli. Such stimuli-sensitive behaviour makes hydrogels appealing for the design of ‘smart’ devices, applicable in a variety of technological fields. In particular, in cases where either ecological or biocompatibility issues are concerned, the biodegradability of the hydrogel network, together with the control of the degradation rate, may provide additional value to the developed device. This review surveys the design and the applications of cellulose-based hydrogels, which are extensively investigated due to the large availability of cellulose in nature, the intrinsic degradability of cellulose and the smart behaviour displayed by some cellulose derivatives.

7 CFR 3560.3 - Environmental requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Environmental requirements. 3560.3 Section 3560.3... Environmental requirements. RHS will consider environmental impacts of proposed housing as equal with economic... a manner that protects, enhances, and restores environmental quality. Loan and grant processing and...

Image guided drug release from pH-sensitive Ion channel-functionalized stealth liposomes into an in vivo glioblastoma model.

PubMed

Pacheco-Torres, Jesus; Mukherjee, Nobina; Walko, Martin; López-Larrubia, Pilar; Ballesteros, Paloma; Cerdan, Sebastian; Kocer, Armagan

2015-08-01

Liposomal drug delivery vehicles are promising nanomedicine tools for bringing cytotoxic drugs to cancerous tissues selectively. However, the triggered cargo release from liposomes in response to a target-specific stimulus has remained elusive. We report on functionalizing stealth-liposomes with an engineered ion channel and using these liposomes in vivo for releasing an imaging agent into a cerebral glioma rodent model. If the ambient pH drops below a threshold value, the channel generates temporary pores on the liposomes, thus allowing leakage of the intraluminal medicines. By using magnetic resonance spectroscopy and imaging, we show that engineered liposomes can detect the mildly acidic pH of the tumor microenvironment with 0.2 pH unit precision and they release their content into C6 glioma tumors selectively, in vivo. A drug delivery system with this level of sensitivity and selectivity to environmental stimuli may well serve as an optimal tool for environmentally-triggered and image-guided drug release. Cancer remains a leading cause of mortality worldwide. With advances in science, delivery systems of anti-cancer drugs have also become sophisticated. In this article, the authors designed and characterized functionalized liposomal vehicles, which would release the drug payload in a highly sensitive manner in response to a change in pH environment in an animal glioma model. The novel data would enable better future designs of drug delivery systems. Copyright © 2015 Elsevier Inc. All rights reserved.

Connectivity in the human brain dissociates entropy and complexity of auditory inputs☆

PubMed Central

Nastase, Samuel A.; Iacovella, Vittorio; Davis, Ben; Hasson, Uri

2015-01-01

Complex systems are described according to two central dimensions: (a) the randomness of their output, quantified via entropy; and (b) their complexity, which reflects the organization of a system's generators. Whereas some approaches hold that complexity can be reduced to uncertainty or entropy, an axiom of complexity science is that signals with very high or very low entropy are generated by relatively non-complex systems, while complex systems typically generate outputs with entropy peaking between these two extremes. In understanding their environment, individuals would benefit from coding for both input entropy and complexity; entropy indexes uncertainty and can inform probabilistic coding strategies, whereas complexity reflects a concise and abstract representation of the underlying environmental configuration, which can serve independent purposes, e.g., as a template for generalization and rapid comparisons between environments. Using functional neuroimaging, we demonstrate that, in response to passively processed auditory inputs, functional integration patterns in the human brain track both the entropy and complexity of the auditory signal. Connectivity between several brain regions scaled monotonically with input entropy, suggesting sensitivity to uncertainty, whereas connectivity between other regions tracked entropy in a convex manner consistent with sensitivity to input complexity. These findings suggest that the human brain simultaneously tracks the uncertainty of sensory data and effectively models their environmental generators. PMID:25536493

Beneficial Use of Dredged Material

EPA Pesticide Factsheets

An important goal of managing dredged material is to ensure that the material is used or disposed of in an environmentally sound manner.Most of this dredged material could be used in a beneficial manner instead.

7 CFR 3565.7 - Agency environmental requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... environmental requirements. The Agency will take into account potential environmental impacts of proposed..., and interested citizens and organizations in order to formulate actions that advance the program goals in a manner that will protect, enhance, and restore environmental quality. Actions taken by the...

Locus coeruleus and dopaminergic consolidation of everyday memory

PubMed Central

Takeuchi, Tomonori; Duszkiewicz, Adrian J.; Sonneborn, Alex; Spooner, Patrick A.; Yamasaki, Miwako; Watanabe, Masahiko; Smith, Caroline C.; Fernández, Guillén; Deisseroth, Karl; Greene, Robert W.; Morris, Richard G. M.

2016-01-01

Summary The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine hydroxylase-expressing (TH+) neurons in the ventral tegmental area (VTA). We report that neuronal firing in the locus coeruleus (LC) is especially sensitive to environmental novelty, LC-TH+ neurons project more profusely than VTA-TH+ neurons to the hippocampus, optogenetic activation of LC-TH+ neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by VTA inactivation. Surprisingly, two effects of LC-TH+ photoactivation are sensitive to hippocampal D1/D5 receptor blockade and resistant to adrenoceptors blockade – memory enhancement and long lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, LC-TH+ neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in hippocampus. PMID:27602521

Locus coeruleus and dopaminergic consolidation of everyday memory.

PubMed

Takeuchi, Tomonori; Duszkiewicz, Adrian J; Sonneborn, Alex; Spooner, Patrick A; Yamasaki, Miwako; Watanabe, Masahiko; Smith, Caroline C; Fernández, Guillén; Deisseroth, Karl; Greene, Robert W; Morris, Richard G M

2016-09-15

The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine-hydroxylase-expressing (TH + ) neurons in the ventral tegmental area. Here we report that neuronal firing in the locus coeruleus is especially sensitive to environmental novelty, locus coeruleus TH + neurons project more profusely than ventral tegmental area TH + neurons to the hippocampus, optogenetic activation of locus coeruleus TH + neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by ventral tegmental area inactivation. Surprisingly, two effects of locus coeruleus TH + photoactivation are sensitive to hippocampal D 1 /D 5 receptor blockade and resistant to adrenoceptor blockade: memory enhancement and long-lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, locus coeruleus TH + neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in the hippocampus.

7 CFR 1940.307 - Environmental responsibilities within the State Office.

Code of Federal Regulations, 2010 CFR

2010-01-01

... any unresolved or difficult environmental issues in a timely manner; and (3) Incorporate into projects... 7 Agriculture 13 2010-01-01 2009-01-01 true Environmental responsibilities within the State Office..., DEPARTMENT OF AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED) GENERAL Environmental Program § 1940...

Hydrogen Production from Nuclear Energy

NASA Astrophysics Data System (ADS)

Walters, Leon; Wade, Dave

2003-07-01

During the past decade the interest in hydrogen as transportation fuel has greatly escalated. This heighten interest is partly related to concerns surrounding local and regional air pollution from the combustion of fossil fuels along with carbon dioxide emissions adding to the enhanced greenhouse effect. More recently there has been a great sensitivity to the vulnerability of our oil supply. Thus, energy security and environmental concerns have driven the interest in hydrogen as the clean and secure alternative to fossil fuels. Remarkable advances in fuel-cell technology have made hydrogen fueled transportation a near-term possibility. However, copious quantities of hydrogen must be generated in a manner independent of fossil fuels if environmental benefits and energy security are to be achieved. The renewable technologies, wind, solar, and geothermal, although important contributors, simply do not comprise the energy density required to deliver enough hydrogen to displace much of the fossil transportation fuels. Nuclear energy is the only primary energy source that can generate enough hydrogen in an energy secure and environmentally benign fashion. Methods of production of hydrogen from nuclear energy, the relative cost of hydrogen, and possible transition schemes to a nuclear-hydrogen economy will be presented.

Environmental surveillance of poliovirus in sewage water around the introduction period for inactivated polio vaccine in Japan.

PubMed

Nakamura, Tomofumi; Hamasaki, Mitsuhiro; Yoshitomi, Hideaki; Ishibashi, Tetsuya; Yoshiyama, Chiharu; Maeda, Eriko; Sera, Nobuyuki; Yoshida, Hiromu

2015-03-01

Environmental virus surveillance was conducted at two independent sewage plants from urban and rural areas in the northern prefecture of the Kyushu district, Japan, to trace polioviruses (PVs) within communities. Consequently, 83 PVs were isolated over a 34-month period from April 2010 to January 2013. The frequency of PV isolation at the urban plant was 1.5 times higher than that at the rural plant. Molecular sequence analysis of the viral VP1 gene identified all three serotypes among the PV isolates, with the most prevalent serotype being type 2 (46%). Nearly all poliovirus isolates exhibited more than one nucleotide mutation from the Sabin vaccine strains. During this study, inactivated poliovirus vaccine (IPV) was introduced for routine immunization on 1 September 2012, replacing the live oral poliovirus vaccine (OPV). Interestingly, the frequency of PV isolation from sewage waters declined before OPV cessation at both sites. Our study highlights the importance of environmental surveillance for the detection of the excretion of PVs from an OPV-immunized population in a highly sensitive manner, during the OPV-to-IPV transition period. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Polybenzoxazole Nanofiber-Reinforced Moisture-Responsive Soft Actuators.

PubMed

Chen, Meiling; Frueh, Johannes; Wang, Daolin; Lin, Xiankun; Xie, Hui; He, Qiang

2017-04-10

Hydromorphic biological systems, such as morning glory flowers, pinecones, and awns, have inspired researchers to design moisture-sensitive soft actuators capable of directly converting the change of moisture into motion or mechanical work. Here, we report a moisture-sensitive poly(p-phenylene benzobisoxazole) nanofiber (PBONF)-reinforced carbon nanotube/poly(vinyl alcohol) (CNT/PVA) bilayer soft actuator with fine performance on conductivity and mechanical properties. The embedded PBONFs not only assist CNTs to form a continuous, conductive film, but also enhance the mechanical performance of the actuators. The PBONF-reinforced CNT/PVA bilayer actuators can unsymmetrically adsorb and desorb water, resulting in a reversible deformation. More importantly, the actuators show a pronounced increase of conductivity due to the deformation induced by the moisture change, which allows the integration of a moisture-sensitive actuator and a humidity sensor. Upon changing the environmental humidity, the actuators can respond by the deformation for shielding and report the humidity change in a visual manner, which has been demonstrated by a tweezer and a curtain. Such nanofiber-reinforced bilayer actuators with the sensing capability should hold considerable promise for the applications such as soft robots, sensors, intelligent switches, integrated devices, and material storage.

Sensitivity analysis in a life cycle assessment of an aged red wine production from Catalonia, Spain.

PubMed

Meneses, M; Torres, C M; Castells, F

2016-08-15

Sustainability in agriculture and food processing is an issue with a clear growing interest; especially in products were consumers have particular awareness regarding its environmental profile. This is the case of wine industry depending on grape production, winemaking and bottling. Also viticulture and generally agricultural production is significantly affected by climate variations. The aim of this article is to determine the environmental load of an aged red wine from a winery in Catalonia, Spain, over its entire life cycle, including sensitivity analysis of the main parameters related to the cultivation, vinification and bottling. The life cycle assessment (LCA) methodology is used for the environmental analysis. In a first step, life cycle inventory (LCI) data were collected by questionnaires and interviews with the winemaker, all data are actual operating data and all the stages involved in the production have been taken into account (viticulture, vinification, bottling and the disposal subsystem). Data were then used to determine the environmental profile by a life cycle impact assessment using the ReCiPe method. Annual variability in environmental performance, stresses the importance of including timeline analysis in the wine sector. Because of that this study is accompanied with a sensitivity analysis carried out by a Monte Carlo simulation that takes into account the uncertainty and variability of the parameters used. In this manner, the results are presented with confidence intervals to provide a wider view of the environmental issues derived from the activities of the studied wine estate regardless of the eventualities of a specific harvesting year. Since the beverage packaging has an important influence in this case, a dataset for the production of green glass was adapted to reflect the actual recycling situation in Spain. Furthermore, a hypothetical variation of the glass-recycling rate in the glass production completes this article, as a key variable of sensitivity analysis, in order… in order to show the potential reduction of total greenhouse gas emissions. It was found that in almost all categories the production of the glass bottles has the highest environmental impact (10%-80% depending on the impact category) followed by the viticulture stage, i.e. the agricultural activities (17%-84% depending on the impact category). The vinification step, i.e. the winemaking itself, has an almost negligible effect on the overall load (1%-5%). The sensitivity analysis showed that the results do not differ by more than ±4% from the expected values except for the water depletion indicator. With the variation of the recycling rate, it could be shown that an increase in the rate from 60% to 85% allows for a reduction of 102gCO2eq. per bottle (-11.1%). The results show that glass production causes the highest environmental load. The key parameters that determine the impact are the recycling rate and the bottle weight. A glass container deposit legislation might be a promising way to enhance the glass recycling. Lightweight bottles and alternative packaging should also be considered. Copyright © 2016 Elsevier B.V. All rights reserved.

Environmental Glossary with Metric Conversion Tables. Revised Edition.

ERIC Educational Resources Information Center

Deason, Wayne O.

This glossary of over 800 environmental terms was prepared specifically for Bureau of Reclamation personnel who write and review environmental assessments and environmental impact statements. The document is designed to ensure that the terminology of various disciplines is understood by all specialists and is used in a consistent manner. Included…

Real-time PCR to supplement gold-standard culture-based detection of Legionella in environmental samples.

PubMed

Collins, S; Jorgensen, F; Willis, C; Walker, J

2015-10-01

Culture remains the gold-standard for the enumeration of environmental Legionella. However, it has several drawbacks including long incubation and poor sensitivity, causing delays in response times to outbreaks of Legionnaires' disease. This study aimed to validate real-time PCR assays to quantify Legionella species (ssrA gene), Legionella pneumophila (mip gene) and Leg. pneumophila serogroup-1 (wzm gene) to support culture-based detection in a frontline public health laboratory. Each qPCR assay had 100% specificity, excellent sensitivity (5 GU/reaction) and reproducibility. Comparison of the assays to culture-based enumeration of Legionella from 200 environmental samples showed that they had a negative predictive value of 100%. Thirty eight samples were positive for Legionella species by culture and qPCR. One hundred samples were negative by both methods, whereas 62 samples were negative by culture but positive by qPCR. The average log10 increase between culture and qPCR for Legionella spp. and Leg. pneumophila was 0·72 (P = 0·0002) and 0·51 (P = 0·006), respectively. The qPCR assays can be conducted on the same 1 l water sample as culture thus can be used as a supplementary technique to screen out negative samples and allow more rapid indication of positive samples. The assay could prove informative in public health investigations to identify or rule out sources of Legionella as well as to specifically identify Leg. pneumophila serogroup 1 in a timely manner not possible with culture. © 2015 The Society for Applied Microbiology.

Study Sensitivity: Evaluating the Ability to Detect Effects in Systematic Reviews of Chemical Exposures

PubMed Central

Cooper, Glinda S.; Lunn, Ruth M.; Ågerstrand, Marlene; Glenn, Barbara S.; Kraft, Andrew D.; Luke, April M.; Ratcliffe, Jennifer M.

2016-01-01

A critical step in systematic reviews of potential health hazards is the structured evaluation of the strengths and weaknesses of the included studies; risk of bias is a term often used to represent this process, specifically with respect to the evaluation of systematic errors that can lead to inaccurate (biased) results (i.e. focusing on internal validity). Systematic review methods developed in the clinical medicine arena have been adapted for use in evaluating environmental health hazards; this expansion raises questions about the scope of risk of bias tools and the extent to which they capture the elements that can affect the interpretation of results from environmental and occupational epidemiology studies and in vivo animal toxicology studies, (the studies typically available for assessment of risk of chemicals). One such element, described here as “sensitivity”, is a measure of the ability of a study to detect a true effect or hazard. This concept is similar to the concept of the sensitivity of an assay; an insensitive study may fail to show a difference that truly exists, leading to a false conclusion of no effect. Factors relating to study sensitivity should be evaluated in a systematic manner with the same rigor as the evaluation of other elements within a risk of bias framework. We discuss the importance of this component for the interpretation of individual studies, examine approaches proposed or in use to address it, and describe how it relates to other evaluation components. The evaluation domains contained within a risk of bias tool can include, or can be modified to include, some features relating to study sensitivity; the explicit inclusion of these sensitivity criteria with the same rigor and at the same stage of study evaluation as other bias-related criteria can improve the evaluation process. In some cases, these and other features may be better addressed through a separate sensitivity domain. The combined evaluation of risk of bias and sensitivity can be used to identify the most informative studies, to evaluate the confidence of the findings from individual studies and to identify those study elements that may help to explain heterogeneity across the body of literature. PMID:27156196

Concepts of an Environmental Behavior Practice for Sanitarians

ERIC Educational Resources Information Center

Goldsmith, Francis J.

1972-01-01

Expands on the concept that environmental deficiencies are symptoms of human behavior that lead to environmental degradation. Explores the question of why people behave in a manner that is destructive of the environment with a focus on values and value conflict. (LK)

Evaluation of Uncertainty and Sensitivity in Environmental Modeling at a Radioactive Waste Management Site

NASA Astrophysics Data System (ADS)

Stockton, T. B.; Black, P. K.; Catlett, K. M.; Tauxe, J. D.

2002-05-01

Environmental modeling is an essential component in the evaluation of regulatory compliance of radioactive waste management sites (RWMSs) at the Nevada Test Site in southern Nevada, USA. For those sites that are currently operating, further goals are to support integrated decision analysis for the development of acceptance criteria for future wastes, as well as site maintenance, closure, and monitoring. At these RWMSs, the principal pathways for release of contamination to the environment are upward towards the ground surface rather than downwards towards the deep water table. Biotic processes, such as burrow excavation and plant uptake and turnover, dominate this upward transport. A combined multi-pathway contaminant transport and risk assessment model was constructed using the GoldSim modeling platform. This platform facilitates probabilistic analysis of environmental systems, and is especially well suited for assessments involving radionuclide decay chains. The model employs probabilistic definitions of key parameters governing contaminant transport, with the goals of quantifying cumulative uncertainty in the estimation of performance measures and providing information necessary to perform sensitivity analyses. This modeling differs from previous radiological performance assessments (PAs) in that the modeling parameters are intended to be representative of the current knowledge, and the uncertainty in that knowledge, of parameter values rather than reflective of a conservative assessment approach. While a conservative PA may be sufficient to demonstrate regulatory compliance, a parametrically honest PA can also be used for more general site decision-making. In particular, a parametrically honest probabilistic modeling approach allows both uncertainty and sensitivity analyses to be explicitly coupled to the decision framework using a single set of model realizations. For example, sensitivity analysis provides a guide for analyzing the value of collecting more information by quantifying the relative importance of each input parameter in predicting the model response. However, in these complex, high dimensional eco-system models, represented by the RWMS model, the dynamics of the systems can act in a non-linear manner. Quantitatively assessing the importance of input variables becomes more difficult as the dimensionality, the non-linearities, and the non-monotonicities of the model increase. Methods from data mining such as Multivariate Adaptive Regression Splines (MARS) and the Fourier Amplitude Sensitivity Test (FAST) provide tools that can be used in global sensitivity analysis in these high dimensional, non-linear situations. The enhanced interpretability of model output provided by the quantitative measures estimated by these global sensitivity analysis tools will be demonstrated using the RWMS model.

Factors influencing frontal cortex development and recovery from early frontal injury.

PubMed

Halliwell, Celeste; Comeau, Wendy; Gibb, Robbin; Frost, Douglas O; Kolb, Bryan

2009-01-01

Neocortical development represents more than a simple unfolding of a genetic blueprint but rather represents a complex dance of genetic and environmental events that interact to adapt the brain to fit a particular environmental context. Although most cortical regions are sensitive to a wide range of experiential factors during development and later in life, the prefrontal cortex appears to be unusually sensitive to perinatal experiences and relatively immune to many adulthood experiences relative to other neocortical regions. One way to examine experience-dependent prefrontal development is to conduct studies in which experiential perturbations are related neuronal morphology. This review of the research reveals both pre- and post-natal factors have important effects on prefrontal development and behaviour. Such factors include psychoactive drugs, including both illicit drugs and prescription drugs, stress, gonadal hormones and sensory and motor stimulation. A second method of study is to examine both the effects of perinatal prefrontal injury on the development of the remaining cerebral mantle and correlated behaviours as well as the effects of post-injury rehabilitation programmes on the anatomical and behavioural measures. Prefrontal injury alters cerebral development in a developmental-stage dependent manner with perinatal injuries having far more deleterious effects than similar injuries later in infancy. The outcome of perinatal injuries can be modified, however, by rehabilitation with many of the factors shown to influence prefrontal development in the otherwise normal brain.

Connectivity in the human brain dissociates entropy and complexity of auditory inputs.

PubMed

Nastase, Samuel A; Iacovella, Vittorio; Davis, Ben; Hasson, Uri

2015-03-01

Complex systems are described according to two central dimensions: (a) the randomness of their output, quantified via entropy; and (b) their complexity, which reflects the organization of a system's generators. Whereas some approaches hold that complexity can be reduced to uncertainty or entropy, an axiom of complexity science is that signals with very high or very low entropy are generated by relatively non-complex systems, while complex systems typically generate outputs with entropy peaking between these two extremes. In understanding their environment, individuals would benefit from coding for both input entropy and complexity; entropy indexes uncertainty and can inform probabilistic coding strategies, whereas complexity reflects a concise and abstract representation of the underlying environmental configuration, which can serve independent purposes, e.g., as a template for generalization and rapid comparisons between environments. Using functional neuroimaging, we demonstrate that, in response to passively processed auditory inputs, functional integration patterns in the human brain track both the entropy and complexity of the auditory signal. Connectivity between several brain regions scaled monotonically with input entropy, suggesting sensitivity to uncertainty, whereas connectivity between other regions tracked entropy in a convex manner consistent with sensitivity to input complexity. These findings suggest that the human brain simultaneously tracks the uncertainty of sensory data and effectively models their environmental generators. Copyright © 2014. Published by Elsevier Inc.

On the deterministic and stochastic use of hydrologic models

USGS Publications Warehouse

Farmer, William H.; Vogel, Richard M.

2016-01-01

Environmental simulation models, such as precipitation-runoff watershed models, are increasingly used in a deterministic manner for environmental and water resources design, planning, and management. In operational hydrology, simulated responses are now routinely used to plan, design, and manage a very wide class of water resource systems. However, all such models are calibrated to existing data sets and retain some residual error. This residual, typically unknown in practice, is often ignored, implicitly trusting simulated responses as if they are deterministic quantities. In general, ignoring the residuals will result in simulated responses with distributional properties that do not mimic those of the observed responses. This discrepancy has major implications for the operational use of environmental simulation models as is shown here. Both a simple linear model and a distributed-parameter precipitation-runoff model are used to document the expected bias in the distributional properties of simulated responses when the residuals are ignored. The systematic reintroduction of residuals into simulated responses in a manner that produces stochastic output is shown to improve the distributional properties of the simulated responses. Every effort should be made to understand the distributional behavior of simulation residuals and to use environmental simulation models in a stochastic manner.

78 FR 50052 - Chief of Engineers Environmental Advisory Board; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-16

... environmentally sustainable manner. Discussions and presentations during this meeting will include flow management...., drivers license, state- issued photo ID, or passport), and pass through the security screening station...

EPA PROGRAMS AND THE REGULATION OF CARCINOGENS: METHODS AND PHILOSOPHIES

EPA Science Inventory

This report is part of the National Network for Environmental Studies Program conducted under the auspices of the Office of Cooperative Environmental Management, U.S. Environmental Protection Agency. This is a group paper which discusses the manner in which the EPA identifies, as...

44 CFR 10.4 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... approach that will ensure the integrated use of the natural and social sciences, and environmental... GENERAL ENVIRONMENTAL CONSIDERATIONS General § 10.4 Policy. (a) FEMA shall act with care to assure that... mitigation and flood insurance, it does so in a manner consistent with national environmental policies. Care...

44 CFR 10.4 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... approach that will ensure the integrated use of the natural and social sciences, and environmental... GENERAL ENVIRONMENTAL CONSIDERATIONS General § 10.4 Policy. (a) FEMA shall act with care to assure that... mitigation and flood insurance, it does so in a manner consistent with national environmental policies. Care...

Effects of chronic dietary exposure to environmentally relevant concentrations to 2,3,7,8-tetrachlorodibenzo-p-dioxin on survival, growth, reproduction and biochemical responses of female rainbow trout (Oncorhynchus mykiss)

USGS Publications Warehouse

Giesy, John P.; Jones, Paul D.; Kannan, Kurunthachalam; Newsted, John L.; Tillitt, Donald E.; Williams, Lisa L.

2002-01-01

Adult female rainbow trout were exposed to dietary 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at concentrations of 1.8, 18 and 90 ng TCDD/kg (ww) food for up to 300 day. At the end of the exposure fish were spawned and the reproductive outcomes were assessed. TCDD was accumulated into tissues and eggs in a dose-dependent manner with steady state being achieved after 50–100 day of exposure. Biochemical and hematological parameters were monitored at 50, 100, 150, and 200 day after the beginning of exposure. The survival of adult female trout was reduced in a dose-dependent manner by exposure to TCDD in the diet. Fish fed 1.8 ng TCDD/kg, moist weight of diet, showed significantly reduced survival compared with those fed the control diet. TCDD also affected survival of fry from females fed 1.8 ng TCDD/kg. Observed adverse effects in adult fish were as sensitive as early life-stage endpoints. Liver EROD activity was only moderately increased in all exposure groups after 250+ day of exposure. Low rates of edema and deformities were observed in fry from all treatment groups including controls. This study has demonstrated adverse effects of TCDD to both adults and fry at concentrations comparable to current environmental concentrations. This suggests that direct adult toxicity as well as reproductive endpoints need to be incorporated in the current risk assessment paradigm for these compounds.

National Enforcement Initiative: Ensuring Energy Extraction Activities Comply with Environmental Laws

EPA Pesticide Factsheets

This page describes energy extraction and EPA's goal in assuring that energy sources are developed in an environmentally protective manner. Both enforcement cases, and a map of enforcement actions are provided.

Cytotoxicity of lambda-cyhalothrin on the macrophage cell line RAW 264.7.

PubMed

Zhang, Quan; Wang, Cui; Sun, Liwei; Li, Ling; Zhao, Meirong

2010-01-01

The wide use and wide-spectrum toxicity of synthetic pyrethroids (SPs) insecticides make them an emerging ecotoxicological concern. Some previous studies showed that SPs possessed cytotoxicity in some immune cells such as human lymphocytes and rat bone marrow. However, the cytotoxicity of SPs to macrophages, which are crucial to innate immunity, has not been explored. In the present report, we investigated a new pyrethroid insecticide, lambda-cyhalothrin (LCT), which may increase the generation of reactive oxygen species (ROS) and DNA damage levels and cause cytotoxicity in RAW 264.7 cells in dose- and time-dependent manners. The results for the first time implicated increased endogenous ROS and DNA damage as co-mediators of LCT-induced cytotoxicity in macrophages. Our results also suggested that macrophages were involved in synthetic pyrethroid-induced adverse immune effects. Considering the ubiquitous environmental presence of SPs, this study provided new information relative to the potential long-term physiological and immunological effects associated with chronic exposure to SPs. Hence, the potential immunotoxicity of SPs should be considered in assessing the safety of these compounds in sensitive environmental compartments.

Discrimination of Nosiheptide Sources with Plasmonic Filters.

PubMed

Wang, Delong; Ni, Haibin; Wang, Zhongqiang; Liu, Bing; Chen, Hongyuan; Gu, Zhongze; Zhao, Xiangwei

2017-04-19

Bacteria identification plays a vital role in the field of clinical diagnosis, food industry, and environmental monitoring, which is in great demand of point of care detection methods. In this paper, in order to discriminate the source of nosiheptide product, a plasmonic filter was fabricated to filtrate, capture and identify Streptomycete spores with Surface enhanced Raman Scattering (SERS). Since the plasmonic filter was derived from self-assembled photonic crystal coated with silver, the plasmonic "hot spots" on the filter surface was distributed evenly in a fare good density and the SERS enhancement factor was 7.49 × 10 7 . With this filter, a stain- and PCR-free detection was realized with only 5 μL sample solution and 5 min in a manner of "filtration and measure". Comparison to traditional Gram stain method and silver-plated nylon filter membrane, the plasmonic filter showed good sensitivity and efficiency in the discrimination of nosiheptide prepared with chemical and biological methods. It is anticipated that this simple SERS detection method with plasmonic filter has promising potentials in food safety, environmental, or clinical applications.

Genetic Moderation of Transactional Relations Between Parenting Practices and Child Self-Regulation

PubMed Central

Cho, Junhan; Kogan, Steven M.; Brody, Gene H.

2016-01-01

The present study addressed the ways in which parent and child dopamine D4 receptor (DRD4) genotypes jointly moderate the transactional relations between parenting practices and child self-regulation. African American children (N = 309) and their parents provided longitudinal data spanning child ages 11 to 15 years and a saliva sample from which variation at DRD4 was genotyped. Based on the differential susceptibility perspective, this study examined moderation effects of DRD4 status on (a) the extent to which parenting practices affect child self-regulation and (b) the extent to which child self-regulation, as an environmental influence on the parent, affects parenting behavior. Results indicated that responsive-supportive parenting interacted with children’s DRD4 status to influence increases in child self-regulation. Also, child self-regulation interacted with parent’s DRD4 status to predict changes in parenting practices. Both G × E effects conformed to a differential susceptibility model in which parents’ and children’s DRD4 genes operated to increase environmental sensitivity in a “for better and for worse” manner. PMID:27548745

40 CFR 266.21 - Standards applicable to generators and transporters of materials used in a manner that...

Code of Federal Regulations, 2010 CFR

2010-07-01

... transporters of materials used in a manner that constitutes disposal. 266.21 Section 266.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Recyclable...

Study sensitivity: Evaluating the ability to detect effects in systematic reviews of chemical exposures.

PubMed

Cooper, Glinda S; Lunn, Ruth M; Ågerstrand, Marlene; Glenn, Barbara S; Kraft, Andrew D; Luke, April M; Ratcliffe, Jennifer M

2016-01-01

A critical step in systematic reviews of potential health hazards is the structured evaluation of the strengths and weaknesses of the included studies; risk of bias is a term often used to represent this process, specifically with respect to the evaluation of systematic errors that can lead to inaccurate (biased) results (i.e. focusing on internal validity). Systematic review methods developed in the clinical medicine arena have been adapted for use in evaluating environmental health hazards; this expansion raises questions about the scope of risk of bias tools and the extent to which they capture the elements that can affect the interpretation of results from environmental and occupational epidemiology studies and in vivo animal toxicology studies, (the studies typically available for assessment of risk of chemicals). One such element, described here as "sensitivity", is a measure of the ability of a study to detect a true effect or hazard. This concept is similar to the concept of the sensitivity of an assay; an insensitive study may fail to show a difference that truly exists, leading to a false conclusion of no effect. Factors relating to study sensitivity should be evaluated in a systematic manner with the same rigor as the evaluation of other elements within a risk of bias framework. We discuss the importance of this component for the interpretation of individual studies, examine approaches proposed or in use to address it, and describe how it relates to other evaluation components. The evaluation domains contained within a risk of bias tool can include, or can be modified to include, some features relating to study sensitivity; the explicit inclusion of these sensitivity criteria with the same rigor and at the same stage of study evaluation as other bias-related criteria can improve the evaluation process. In some cases, these and other features may be better addressed through a separate sensitivity domain. The combined evaluation of risk of bias and sensitivity can be used to identify the most informative studies, to evaluate the confidence of the findings from individual studies and to identify those study elements that may help to explain heterogeneity across the body of literature. Copyright © 2016. Published by Elsevier Ltd.

Climatic conditions produce contrasting influences on demographic traits in a long-distance Arctic migrant.

PubMed

Cleasby, Ian R; Bodey, Thomas W; Vigfusdottir, Freydis; McDonald, Jenni L; McElwaine, Graham; Mackie, Kerry; Colhoun, Kendrew; Bearhop, Stuart

2017-03-01

The manner in which patterns of variation and interactions among demographic rates contribute to population growth rate (λ) is key to understanding how animal populations will respond to changing climatic conditions. Migratory species are likely to be particularly sensitive to climatic conditions as they experience a range of different environments throughout their annual cycle. However, few studies have provided fully integrated demographic analyses of migratory populations in response to changing climatic conditions. Here, we employed integrated population models to demonstrate that the environmental conditions experienced during a short but critical period play a central role in the demography of a long-distance migrant, the light-bellied Brent goose (Branta bernicla hrota). Female survival was positively associated with June North Atlantic Oscillation (NAO) values, whereas male survival was not. In contrast, breeding productivity was negatively associated with June NAO, suggesting a trade-off between female survival and reproductive success. Both adult female and adult male survival showed low temporal variation, whereas there was high temporal variation in recruitment and breeding productivity. In addition, while annual population growth was positively correlated with annual breeding productivity, a sensitivity analysis revealed that population growth was most sensitive to changes in adult survival. Our results demonstrate that the environmental conditions experienced during a relatively short-time window at the start of the breeding season play a critical role in shaping the demography of a long-distant Arctic migrant. Crucially, different demographic rates responded in opposing directions to climatic variation, emphasising the need for integrated analysis of multiple demographic traits when understanding population dynamics. © 2016 The Authors. Journal of Animal Ecology © 2016 British Ecological Society.

Harvesting forest biomass for energy in Minnesota: An assessment of guidelines, costs and logistics

NASA Astrophysics Data System (ADS)

Saleh, Dalia El Sayed Abbas Mohamed

The emerging market for renewable energy in Minnesota has generated a growing interest in utilizing more forest biomass for energy. However, this growing interest is paralleled with limited knowledge of the environmental impacts and cost effectiveness of utilizing this resource. To address environmental and economic viability concerns, this dissertation has addressed three areas related to biomass harvest: First, existing biomass harvesting guidelines and sustainability considerations are examined. Second, the potential contribution of biomass energy production to reduce the costs of hazardous fuel reduction treatments in these trials is assessed. Third, the logistics of biomass production trials are analyzed. Findings show that: (1) Existing forest related guidelines are not sufficient to allow large-scale production of biomass energy from forest residue sustainably. Biomass energy guidelines need to be based on scientific assessments of how repeated and large scale biomass production is going to affect soil, water and habitat values, in an integrated and individual manner over time. Furthermore, such guidelines would need to recommend production logistics (planning, implementation, and coordination of operations) necessary for a potential supply with the least site and environmental impacts. (2) The costs of biomass production trials were assessed and compared with conventional treatment costs. In these trials, conventional mechanical treatment costs were lower than biomass energy production costs less income from biomass sale. However, a sensitivity analysis indicated that costs reductions are possible under certain site, prescriptions and distance conditions. (3) Semi-structured interviews with forest machine operators indicate that existing fuel reduction prescriptions need to be more realistic in making recommendations that can overcome operational barriers (technical and physical) and planning and coordination concerns (guidelines and communications) identified by machine operators, and which are necessary for a viable biomass energy production system. The results of this dissertation suggest that once biomass energy production is intended, incorporating an early understanding of production logistics while developing environmentally sensitive guidelines and site-specific prescriptions can improve biomass energy production, costs, performance and sustainability.

Grand Manner Aesthetics in Landscape: From Canvas to Celluloid

ERIC Educational Resources Information Center

Auger, Emily E.

2009-01-01

The methods by which environmental issues are aestheticized in late-twentieth-century film is directly and historically related to those established for grand manner painters by Nicholas Poussin (1594-1665) and taught at the French academy from the seventeenth through the nineteenth centuries. That these fundamentals were part of the training of…

A rainfall risk analysis thanks to an GIS based estimation of urban vulnerability

NASA Astrophysics Data System (ADS)

Renard, Florent; Pierre-Marie, Chapon

2010-05-01

The urban community of Lyon, situated in France in the north of the Rhône valley, comprises 1.2 million inhabitants within 515 km ². With such a concentration of issues, policy makers and local elected officials therefore attach great importance to the management of hydrological risks, particularly due to the inherent characteristics of the territory. If the hazards associated with these risks in the territory of Lyon have been the subject of numerous analyses, studies on the vulnerability of greater Lyon are rare and have common shortcomings that impair their validity. We recall that the risk is seen as the classic relationship between the probability of occurrence of hazards and vulnerability. In this article, this vulnerability will be composed of two parts. The first one is the sensitivity of the stakes facing hydrological hazards as urban runoff, that is to say, their propensity to suffer damage during a flood (Gleize and Reghezza, 2007). The second factor is their relative importance in the functioning of the community. Indeed, not all the stakes could provide the same role and contribution to the Greater Lyon. For example, damage to the urban furniture such as bus shelter seems less harmful to the activities of the urban area than that of transport infrastructure (Renard and Chapon, 2010). This communication proposes to assess the vulnerability of Lyon urban area facing to hydrological hazards. This territory is composed of human, environmental and material stakes. The first part of this work is to identify all these issues so as to completeness. Then, is it required to build a "vulnerability index" (Tixier et al, 2006). Thus, it is necessary to use methods of multicriteria decision aid to evaluate the two components of vulnerability: the sensitivity and the contribution to the functioning of the community. Finally, the results of the overall vulnerability are presented, and then coupled to various hazards related to water such as runoff associated with heavy rains, to locate areas of risk in the urban area. The targets that share the same rank of this vulnerability index do not possess the same importance, or the same sensitivity to the flood hazard. Therefore, the second part of this work is to define the priorities and sensitivities of different targets based on the judgments of experts. Multicriteria decision methods are used to prioritize elements and are therefore adapted to the modelling of the sensitivity of the issues of greater Lyon (Griot, 2008). The purpose of these methods is the assessment of priorities between the different components of the situation. Thomas Saaty's analytic hierarchy process (1980) is the most frequently used because of its many advantages. On this basis, the formal calculations of priorities and sensitivities of the elements have been conducted. These calculations are based on the judgments of experts. Indeed, during semi-structured interview, the 38 experts in our sample delivered a verdict on issues that seem relatively more important than others by binary comparison. They carry the same manner to determine sensitivity's stakes to hazard flooding. Finally, the consistency of answers given by experts is validated by calculating a ratio of coherence, and their results are aggregated to provide functions of priority (based on the relative importance of each stakes), and functions of sensitivity (based on the relative sensitivity of each stakes). From these functions of priority and sensitivity is obtained the general function of vulnerability. The vulnerability functions allow defining the importance of the stakes of Greater Lyon and their sensitivity to hydrological hazards. The global vulnerability function is obtained from sensitivity and priority functions and shows the great importance of human issues (75 %). The vulnerability factor of environmental targets represents 12 % of the global vulnerability function, as much as the materials issues. However, it can be seen that the environmental and material stakes do not represent the same weight into the priority and sensitivity functions. Indeed, the environmental issues seem more important than the material ones (17 % for the environmental stakes whereas only 5 % for the material stakes in the priority function), but less sensitive to an hydrological hazard (6 % for the environmental issues while 20 % for the material issues in the sensitivity function). Similarly, priority functions and sensitivity are established for all stakes at all levels. The stakes are then converted into a mesh form (100 meters wide). This will standardize the collection framework and the heterogeneous nature of data to allow their comparison. Finally, it is obtained a detailed, consistent and objective vulnerability of the territory of Greater Lyon. At the end, to get a direct reading of risk, combination of hazard and vulnerability, it is overlaid the two maps.

The Exposure Data Landscape for Manufactured Chemicals

EPA Science Inventory

The U.S. Environmental Protection Agency is developing chemical screening and prioritization programs to evaluate environmental chemicals for potential risk to human health in a rapid and efficient manner. As part of these efforts, it is important to catalog available information...

A Measure of Quality

ERIC Educational Resources Information Center

Environmental Science and Technology, 1976

1976-01-01

Recent national surveys conducted by the Council on Environmental Quality and others uncovered inconsistencies and confusion in the manner environmental quality parameters were used and reported. A standard air pollution index, comparative guide to water quality indicators and biological monitoring information are being developed. (BT)

Environmental Sensitivity in Children: Development of the Highly Sensitive Child Scale and Identification of Sensitivity Groups

ERIC Educational Resources Information Center

Pluess, Michael; Assary, Elham; Lionetti, Francesca; Lester, Kathryn J.; Krapohl, Eva; Aron, Elaine N.; Aron, Arthur

2018-01-01

A large number of studies document that children differ in the degree they are shaped by their developmental context with some being more sensitive to environmental influences than others. Multiple theories suggest that "Environmental Sensitivity" is a common trait predicting the response to negative as well as positive exposures.…

24 CFR 50.19 - Categorical exclusions not subject to the Federal laws and authorities cited in § 50.4.

Code of Federal Regulations, 2010 CFR

2010-04-01

... implementation of these categories of activities and policy documents does not require environmental review, because they do not alter physical conditions in a manner or to an extent that would require review under... ENVIRONMENTAL QUALITY General Policy: Environmental Review Procedures § 50.19 Categorical exclusions not subject...

Taxometric and Factor Analytic Models of Anxiety Sensitivity among Youth: Exploring the Latent Structure of Anxiety Psychopathology Vulnerability

ERIC Educational Resources Information Center

Bernstein, Amit; Zvolensky, Michael J.; Stewart, Sherry; Comeau, Nancy

2007-01-01

This study represents an effort to better understand the latent structure of anxiety sensitivity (AS), a well-established affect-sensitivity individual difference factor, among youth by employing taxometric and factor analytic approaches in an integrative manner. Taxometric analyses indicated that AS, as indexed by the Child Anxiety Sensitivity…

40 CFR 266.22 - Standards applicable to storers of materials that are to be used in a manner that constitutes...

Code of Federal Regulations, 2010 CFR

2010-07-01

... materials that are to be used in a manner that constitutes disposal who are not the ultimate users. 266.22 Section 266.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE...

Model approaches for estimating the influence of time-varying socio-environmental factors on macroparasite transmission in two endemic regions

PubMed Central

ZHONG, BO; CARLTON, ELIZABETH J.; SPEAR, ROBERT C.

2009-01-01

The environmental determinants of vector- and host-borne diseases include time-varying components that modify key transmission parameters, resulting in transient couplings between environmental phenomena and transmission processes. While some time-varying drivers are periodic in nature, some are aperiodic, such as those that involve episodic events or complex patterns of human behavior. Understanding these couplings can allow for prediction of periods of peak infection risk, and ultimately presents opportunities for optimizing intervention selection and timing. Schistosome macroparasites of humans exhibit multiple free-living stages as well as intermediate hosts, and are thus model organisms for illustrating the influence of environmental forcing on transmission. Time-varying environmental factors, termed gating functions, for schistosomes include larval response to temperature and rainfall, seasonal water contact patterns and snail population dynamics driven by weather variables. The biological bases for these modifiers are reviewed, and their values are estimated and incorporated into a transmission model that simulates a multi-year period in two schistosomiasis endemic regions. Modeling results combined with a scale dependent correlation analysis indicate the end effect of these site-specific gating functions is to strongly govern worm burden in these communities, in a manner particularly sensitive to the hydrological differences between sites. Two classes of gating functions were identified, those that act in concert to modify human infection (and determine worm acquisition late in the season), and those that act on snail infection (and determine early season worm acquisition). The importance of these factors for control programs and surveillance is discussed. PMID:20454601

30 CFR 556.82 - Environmental studies.

Code of Federal Regulations, 2014 CFR

2014-07-01

... extent practicable, be designed to predict environmental impacts of pollutants introduced into the... a manner designed to provide information which can be compared with the results of studies conducted... quality and productivity of such environments, to establish trends in the areas studies, and to design...

30 CFR 556.82 - Environmental studies.

Code of Federal Regulations, 2013 CFR

2013-07-01

... extent practicable, be designed to predict environmental impacts of pollutants introduced into the... a manner designed to provide information which can be compared with the results of studies conducted... quality and productivity of such environments, to establish trends in the areas studies, and to design...

30 CFR 556.82 - Environmental studies.

Code of Federal Regulations, 2012 CFR

2012-07-01

... extent practicable, be designed to predict environmental impacts of pollutants introduced into the... a manner designed to provide information which can be compared with the results of studies conducted... quality and productivity of such environments, to establish trends in the areas studies, and to design...

Internal complexity and environmental sensitivity in hospitals.

PubMed

Ashmos, D P; Duchon, D; Hauge, F E; McDaniel, R R

1996-01-01

Theory suggests that organizations should respond to external complexity with internal complexity. We examine whether "environmentally sensitive" hospitals are more internally complex than "environmentally insensitive" hospitals. Results show that environmentally sensitive and insensitive hospitals differed on three of the measures of internal complexity: goal complexity, strategic complexity, and relational complexity.

Time-response characteristic and potential biomarker identification of heavy metal induced toxicity in zebrafish.

PubMed

Yin, Jian; Wang, Ai-Ping; Li, Wan-Fang; Shi, Rui; Jin, Hong-Tao; Wei, Jin-Feng

2018-01-01

The present work aims to explore the time-response (from 24 h to 96 h) characteristic and identify early potential sensitive biomarkers of copper (Cu) (as copper chloride dihydrate), cadmium (Cd) (as cadmium acetate), lead (Pb) (as lead nitrate) and chromium (Cr) (as potassium dichromate) exposure in adult zebrafish, focusing on reactive oxygen species (ROS), SOD activity, lipid peroxidation and gene expression related to oxidative stress and inflammatory response. Furthermore, the survival rate decreased apparently by a concentration-dependent manner after Cu, Cr, Cd and Pb exposure, and we selected non-lethal concentrations 0.05 mg/L for Cu, 15 mg/L for Cr, 3 mg/L for Cd and 93.75μg/L for Pb to test the effect on the following biological indicators. Under non-lethal concentration, the four heavy metals have no apparent histological change in adult zebrafish gills. Similar trends in ROS production, MDA level and SOD activity were up-regulated by the four heavy metals, while MDA level responded more sensitive to Pb by time-dependent manner than the other three heavy metals. In addition, mRNA levels related to antioxidant system (SOD1, SOD2 and Nrf2) were up-regulated by non-lethal concentration Cu, Cr, Cd and Pb exposure. MDA level and SOD1 gene have a more delayed response to heavy metals. Genes related to immunotoxicity were increased significantly after heavy metals exposure at non-lethal concentrations. TNF-α and IL-1β gene have similar sensibility to the four heavy metals, while IL-8 gene was more responsive to Cr, Cd and Pb exposure at 48 h groups and IFN-γ gene showed more sensitivity to Cu at 48 h groups than the other heavy metals. In conclusion, the present works have suggested that the IFN-γ gene may applied as early sensitive biomarker to identify Cu-induced toxicity, while MDA content and IL-8 gene may use as early sensitive biomarkers for evaluating the risk of Pb exposure. Moreover, IL-8 and IFN-γ gene were more responsive to heavy metals, which may become early sensitive and potential biomarkers for evaluating inflammatory response induced by heavy metals. This work reinforces the concept of the usefulness of gene expression assays in the evaluation of chemicals effects and helps to establish a background data as well as contributes to evaluate early environmental risk for chemicals, even predicting toxicity. Copyright © 2017 Elsevier Ltd. All rights reserved.

Integrating genetic and toxicogenomic information for determining underlying susceptibility to developmental disorders.

PubMed

Robinson, Joshua F; Port, Jesse A; Yu, Xiaozhong; Faustman, Elaine M

2010-10-01

To understand the complex etiology of developmental disorders, an understanding of both genetic and environmental risk factors is needed. Human and rodent genetic studies have identified a multitude of gene candidates for specific developmental disorders such as neural tube defects (NTDs). With the emergence of toxicogenomic-based assessments, scientists now also have the ability to compare and understand the expression of thousands of genes simultaneously across strain, time, and exposure in developmental models. Using a systems-based approach in which we are able to evaluate information from various parts and levels of the developing organism, we propose a framework for integrating genetic information with toxicogenomic-based studies to better understand gene-environmental interactions critical for developmental disorders. This approach has allowed us to characterize candidate genes in the context of variables critical for determining susceptibility such as strain, time, and exposure. Using a combination of toxicogenomic studies and complementary bioinformatic tools, we characterize NTD candidate genes during normal development by function (gene ontology), linked phenotype (disease outcome), location, and expression (temporally and strain-dependent). In addition, we show how environmental exposures (cadmium, methylmercury) can influence expression of these genes in a strain-dependent manner. Using NTDs as an example of developmental disorder, we show how simple integration of genetic information from previous studies into the standard microarray design can enhance analysis of gene-environment interactions to better define environmental exposure-disease pathways in sensitive and resistant mouse strains. © Wiley-Liss, Inc.

Antihyperglycemic effect of syringaldehyde in streptozotocin-induced diabetic rats.

PubMed

Huang, Chia-Hsin; Chen, Mei-Fen; Chung, Hsien-Hui; Cheng, Juei-Tang

2012-08-24

The antihyperglycemic effect of syringaldehyde (1), purified from the stems of Hibiscus taiwanensis, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) showing type-1 like diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 7.2 mg/kg of 1 attenuated significantly the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. A glucose uptake test showed that 1 exhibits an increase of glucose uptake activity in a concentration-related manner. Moreover, an effect by 1 was shown for insulin sensitivity in STZ-diabetic rats. The compound was found to increase insulin sensitivity in STZ-diabetic rats. These results suggest that syringaldehyde (1) can increase glucose utilization and insulin sensitivity to lower plasma glucose in diabetic rats.

Environmentally Responsible Redox Chemistry: An Example of Convenient Oxidation Methodology without Chromium Waste

ERIC Educational Resources Information Center

Crumbie, Robyn L.

2006-01-01

The reactions use recyclable Magtrieve as the oxidant in a simple reaction sequence illustrating the reciprocity of oxidation and reduction processes. The reciprocity of oxidation and reduction reactions are explored while undertaking the reactions in an environmentally friendly manner.

Effects of a commonly used glyphosate-based herbicide formulation on early developmental stages of two anuran species.

PubMed

Wagner, Norman; Müller, Hendrik; Viertel, Bruno

2017-01-01

Environmental contamination, especially due to the increasing use of pesticides, is suggested to be one out of six main reasons for the global amphibian decline. Adverse effects of glyphosate-based herbicides on amphibians have been already discussed in several studies with different conclusions, especially regarding sublethal effects at environmentally relevant concentrations. Therefore, we studied the acute toxic effects (mortality, growth, and morphological changes) of the commonly used glyphosate-based herbicide formulation Roundup® UltraMax on early aquatic developmental stages of two anuran species with different larval types (obligate vs. facultative filtrating suspension feeders), the African clawed frog (Xenopus laevis) and the Mediterranean painted frog (Discoglossus pictus). While X. laevis is an established anuran model organism in amphibian toxicological studies, we aim to establish D. pictus as another model for species with facultative filtrating larvae. A special focus of the present study lies on malformations in X. laevis embryos, which were investigated using histological preparations. In general, embryos and larvae of X. laevis reacted more sensitive concerning lethal effects compared to early developmental stages of D. pictus. It was suggested, that especially the different morphology of their filter apparatus and the higher volume of water pumped through the buccopharynx of X. laevis larvae lead to higher exposure to the formulation. The test substance induced similar lethal effects in D. pictus larvae as it does in the teleost standard test organism used in pesticide approval, the rainbow trout (Oncorhynchus mykiss), whereas embryos of both species are apparently more tolerant and, conversely, X. laevis larvae about two times more sensitive. In both species, early larvae always reacted significantly more sensitive than embryos. Exposure to the test substance increased malformation rates in embryos of both species in a concentration-dependent manner, but not at environmentally relevant concentrations. However, the assumed field safety, based on calculated surface water concentrations of the active ingredient (glyphosate), should be validated with realistic field data and buffer strips have to be urgently regarded to any aquatic amphibian habitat.

Social Environmental Variation, Plasticity Genes, and Aggression: Evidence for the Differential Susceptibility Hypothesis

PubMed Central

Simons, Ronald L.; Lei, Man Kit; Beach, Steven R.H.; Brody, Gene H.; Philibert, Robert A.; Gibbons, Frederick X.

2011-01-01

Although G×E studies are typically based on the assumption that some individuals possess genetic variants that enhance their vulnerability to environmental adversity, the differential susceptibility perspective posits that these individuals are simply more susceptible to environmental influence than others. An important implication of this model is that those persons most vulnerable to adverse social environments are the same ones who reap the most benefit from environmental support. The present study tested several implications of this proposition. Using longitudinal data from a sample of several hundred African Americans, we found that relatively common variants of the dopamine receptor gene and the serotonin transporter gene interact with social environmental conditions to predict aggression in a manner consonant with differential susceptibility. When the social environment was adverse, individuals with these genetic variants manifested more aggression than other genotypes, whereas when the environment was supportive they demonstrated less aggression than other genotypes. Further, we found that these genetic variants interact with environmental conditions to foster various cognitive schemas and emotions in a manner consistent with differential susceptibility and that a latent construct formed by these schemas and emotions mediated the effect of gene by environment interaction on aggression. PMID:22199399

Taxometric and Factor Analytic Models of Anxiety Sensitivity: Integrating Approaches to Latent Structural Research

ERIC Educational Resources Information Center

Bernstein, Amit; Zvolensky, Michael J.; Norton, Peter J.; Schmidt, Norman B.; Taylor, Steven; Forsyth, John P.; Lewis, Sarah F.; Feldner, Matthew T.; Leen-Feldner, Ellen W.; Stewart, Sherry H.; Cox, Brian

2007-01-01

This study represents an effort to better understand the latent structure of anxiety sensitivity (AS), as indexed by the 16-item Anxiety Sensitivity Index (ASI; S. Reiss, R. A. Peterson, M. Gursky, & R. J. McNally, 1986), by using taxometric and factor-analytic approaches in an integrative manner. Taxometric analyses indicated that AS has a…

Estimation of genetic variance for macro- and micro-environmental sensitivity using double hierarchical generalized linear models.

PubMed

Mulder, Han A; Rönnegård, Lars; Fikse, W Freddy; Veerkamp, Roel F; Strandberg, Erling

2013-07-04

Genetic variation for environmental sensitivity indicates that animals are genetically different in their response to environmental factors. Environmental factors are either identifiable (e.g. temperature) and called macro-environmental or unknown and called micro-environmental. The objectives of this study were to develop a statistical method to estimate genetic parameters for macro- and micro-environmental sensitivities simultaneously, to investigate bias and precision of resulting estimates of genetic parameters and to develop and evaluate use of Akaike's information criterion using h-likelihood to select the best fitting model. We assumed that genetic variation in macro- and micro-environmental sensitivities is expressed as genetic variance in the slope of a linear reaction norm and environmental variance, respectively. A reaction norm model to estimate genetic variance for macro-environmental sensitivity was combined with a structural model for residual variance to estimate genetic variance for micro-environmental sensitivity using a double hierarchical generalized linear model in ASReml. Akaike's information criterion was constructed as model selection criterion using approximated h-likelihood. Populations of sires with large half-sib offspring groups were simulated to investigate bias and precision of estimated genetic parameters. Designs with 100 sires, each with at least 100 offspring, are required to have standard deviations of estimated variances lower than 50% of the true value. When the number of offspring increased, standard deviations of estimates across replicates decreased substantially, especially for genetic variances of macro- and micro-environmental sensitivities. Standard deviations of estimated genetic correlations across replicates were quite large (between 0.1 and 0.4), especially when sires had few offspring. Practically, no bias was observed for estimates of any of the parameters. Using Akaike's information criterion the true genetic model was selected as the best statistical model in at least 90% of 100 replicates when the number of offspring per sire was 100. Application of the model to lactation milk yield in dairy cattle showed that genetic variance for micro- and macro-environmental sensitivities existed. The algorithm and model selection criterion presented here can contribute to better understand genetic control of macro- and micro-environmental sensitivities. Designs or datasets should have at least 100 sires each with 100 offspring.

DEVELOPMENT AND MATURATION OF THE NERVOUS SYSTEM: NEUROBIOLOGICAL BASIS OF VULNERABILITY TO ENVIRONMENTAL CONTAMINANTS.

EPA Science Inventory

The susceptibility of the developing nervous system to damage following exposure to environmental contaminants is believed to be based upon the critical nature of the organizational events that occur in both a regionally- and temporally-dependent manner. The age-related susceptib...

Risk and Risk Assessment in Environmental Education.

ERIC Educational Resources Information Center

Chiras, Daniel D.

1982-01-01

Risk assessment (the identification of hazards, the determination of the probability of a hazardous event occurring, and an estimation of the severity of such an event's occurrence) is suggested as a technique to be used to analyze current issues in environmental education in an objective manner. (PEB)

Development of a portable analyzer with polymer lab-on-a-chip (LOC) for continuous sampling and monitoring of Pb(II).

PubMed

Jang, A; Zou, Z; MacKnight, E; Wu, P M; Kim, I S; Ahn, C H; Bishop, P L

2009-01-01

A new portable analyzer with polymer lab-on-a-chip (LOC) has been designed, fabricated and fully characterized for continuous sampling and monitoring of lead (Pb(II)) in this work. As the working electrodes of the sensor, bismuth (Bi (III)) which allowed the advantage of being more environmentally friendly than traditional mercury drop electrodes was used, while maintaining similar sensitivity and other desirable characteristics. The size of a portable analyzer was 30 cmx23 cmx7 cm, and the weight was around 3 kg. The small size gives the advantage of being portable for field use while not sacrificing portability for accuracy of measurement. Furthermore, the autonomous system developed in coordination with the development of new polymer LOC integrated with electrochemical sensors can provide an innovative way to monitor surface waters in an efficient, cost-effective and sustainable manner.

Brain-stem evoked potentials and noise effects in seagulls.

PubMed

Counter, S A

1985-01-01

Brain-stem auditory evoked potentials (BAEP) recorded from the seagull were large-amplitude, short-latency, vertex-positive deflections which originate in the eighth nerve and several brain-stem nuclei. BAEP waveforms were similar in latency and configurations to that reported for certain other lower vertebrates and some mammals. BAEP recorded at several pure tone frequencies throughout the seagull's auditory spectrum showed an area of heightened auditory sensitivity between 1 and 3 kHz. This range was also found to be the primary bandwidth of the vocalization output of young seagulls. Masking by white noise and pure tones had remarkable effects on several parameters of the BAEP. In general, the tone- and click-induced BAEP were either reduced or obliterated by both pure tone and white noise maskers of specific signal to noise ratios and high intensity levels. The masking effects observed in this study may be related to the manner in which seagulls respond to intense environmental noise. One possible conclusion is that intense environmental noise, such as aircraft engine noise, may severely alter the seagull's localization apparatus and induce sonogenic stress, both of which could cause collisions with low-flying aircraft.

Neurons as sensors: individual and cascaded chemical sensing.

PubMed

Prasad, Shalini; Zhang, Xuan; Yang, Mo; Ozkan, Cengiz S; Ozkan, Mihrimah

2004-07-15

A single neuron sensor has been developed based on the interaction of gradient electric fields and the cell membrane. Single neurons are rapidly positioned over individual microelectrodes using positive dielectrophoretic traps. This enables the continuous extracellular electrophysiological measurements from individual neurons. The sensor developed using this technique provides the first experimental method for determining single cell sensitivity; the speed of response and the associated physiological changes to a broad spectrum of chemical agents. Binding of specific chemical agents to a specific combination of receptors induces changes to the extracellular membrane potential of a single neuron, which can be translated into unique "signature patterns" (SP), which function as identification tags. Signature patterns are derived using Fast Fourier Transformation (FFT) analysis and Wavelet Transformation (WT) analysis of the modified extracellular action potential. The validity and the sensitivity of the system are demonstrated for a variety of chemical agents ranging from behavior altering chemicals (ethanol), environmentally hazardous agents (hydrogen peroxide, EDTA) to physiologically harmful agents (pyrethroids) at pico- and femto-molar concentrations. The ability of a single neuron to selectively identify specific chemical agents when injected in a serial manner is demonstrated in "cascaded sensing".

Environmental surveillance for polioviruses in the Global Polio Eradication Initiative.

PubMed

Asghar, Humayun; Diop, Ousmane M; Weldegebriel, Goitom; Malik, Farzana; Shetty, Sushmitha; El Bassioni, Laila; Akande, Adefunke O; Al Maamoun, Eman; Zaidi, Sohail; Adeniji, Adekunle J; Burns, Cara C; Deshpande, Jagadish; Oberste, M Steve; Lowther, Sara A

2014-11-01

This article summarizes the status of environmental surveillance (ES) used by the Global Polio Eradication Initiative, provides the rationale for ES, gives examples of ES methods and findings, and summarizes how these data are used to achieve poliovirus eradication. ES complements clinical acute flaccid paralysis (AFP) surveillance for possible polio cases. ES detects poliovirus circulation in environmental sewage and is used to monitor transmission in communities. If detected, the genetic sequences of polioviruses isolated from ES are compared with those of isolates from clinical cases to evaluate the relationships among viruses. To evaluate poliovirus transmission, ES programs must be developed in a manner that is sensitive, with sufficiently frequent sampling, appropriate isolation methods, and specifically targeted sampling sites in locations at highest risk for poliovirus transmission. After poliovirus ceased to be detected in human cases, ES documented the absence of endemic WPV transmission and detected imported WPV. ES provides valuable information, particularly in high-density populations where AFP surveillance is of poor quality, persistent virus circulation is suspected, or frequent virus reintroduction is perceived. Given the benefits of ES, GPEI plans to continue and expand ES as part of its strategic plan and as a supplement to AFP surveillance. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Environmental DNA metabarcoding reveals primary chemical contaminants in freshwater sediments from different land-use types.

PubMed

Xie, Yuwei; Wang, Jizhong; Yang, Jianghua; Giesy, John P; Yu, Hongxia; Zhang, Xiaowei

2017-04-01

Land-use intensification threatens freshwater biodiversity. Freshwater eukaryotic communities are affected by multiple chemical contaminants with a land-use specific manner. However, biodiversities of eukaryotes and their associations with multiple chemical contaminants are largely unknown. This study characterized in situ eukaryotic communities in sediments exposed to mixtures of chemical contaminants and assessed relationships between various environmental variables and eukaryotic communities in sediments from the Nanfei River. Eukaryotic communities in the sediment samples were dominated by Annelida, Arthropoda, Rotifera, Ochrophyta, Chlorophyta and Ciliophora. Alpha-diversities (Shannon entropy) and structures of eukaryotic communities were significantly different between land-use types. According to the results of multiple statistical tests (PCoA, distLM, Mantel and network analysis), dissimilarity of eukaryotic community structures revealed the key effects of pyrethroid insecticides, manganese, zinc, lead, chromium and polycyclic aromatic hydrocarbons (PAHs) on eukaryotic communities in the sediment samples from the Nanfei River. Furthermore, taxa associated with land-use types were identified and several sensitive eukaryotic taxa to some of the primary contaminants were identified as potential indicators to monitor effects of the primary chemical contaminants. Overall, environmental DNA metabarcoding on in situ eukaryotic communities provided a powerful tool for biomonitoring and identifying primary contaminants and their complex effects on benthic eukaryotic communities in freshwater sediments. Copyright © 2016 Elsevier Ltd. All rights reserved.

Application of stable‐isotope labelling techniques for the detection of active diazotrophs

PubMed Central

Angel, Roey; Panhölzl, Christopher; Gabriel, Raphael; Herbold, Craig; Wanek, Wolfgang; Richter, Andreas; Eichorst, Stephanie A.

2017-01-01

Summary Investigating active participants in the fixation of dinitrogen gas is vital as N is often a limiting factor for primary production. Biological nitrogen fixation is performed by a diverse guild of bacteria and archaea (diazotrophs), which can be free‐living or symbionts. Free‐living diazotrophs are widely distributed in the environment, yet our knowledge about their identity and ecophysiology is still limited. A major challenge in investigating this guild is inferring activity from genetic data as this process is highly regulated. To address this challenge, we evaluated and improved several 15N‐based methods for detecting N2 fixation activity (with a focus on soil samples) and studying active diazotrophs. We compared the acetylene reduction assay and the 15N2 tracer method and demonstrated that the latter is more sensitive in samples with low activity. Additionally, tracing 15N into microbial RNA provides much higher sensitivity compared to bulk soil analysis. Active soil diazotrophs were identified with a 15N‐RNA‐SIP approach optimized for environmental samples and benchmarked to 15N‐DNA‐SIP. Lastly, we investigated the feasibility of using SIP‐Raman microspectroscopy for detecting 15N‐labelled cells. Taken together, these tools allow identifying and investigating active free‐living diazotrophs in a highly sensitive manner in diverse environments, from bulk to the single‐cell level. PMID:29027346

General shape optimization capability

NASA Technical Reports Server (NTRS)

Chargin, Mladen K.; Raasch, Ingo; Bruns, Rudolf; Deuermeyer, Dawson

1991-01-01

A method is described for calculating shape sensitivities, within MSC/NASTRAN, in a simple manner without resort to external programs. The method uses natural design variables to define the shape changes in a given structure. Once the shape sensitivities are obtained, the shape optimization process is carried out in a manner similar to property optimization processes. The capability of this method is illustrated by two examples: the shape optimization of a cantilever beam with holes, loaded by a point load at the free end (with the shape of the holes and the thickness of the beam selected as the design variables), and the shape optimization of a connecting rod subjected to several different loading and boundary conditions.

44 CFR 10.4 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Policy. 10.4 Section 10.4... GENERAL ENVIRONMENTAL CONSIDERATIONS General § 10.4 Policy. (a) FEMA shall act with care to assure that... mitigation and flood insurance, it does so in a manner consistent with national environmental policies. Care...

Monoclonal antibody-based broad-specificity immunoassay for monitoring organophosphorus pesticides in environmental water samples

USDA-ARS?s Scientific Manuscript database

The extensive use of organophosphorus pesticides (OPs) in agriculture and domestic settings can result in widespread water contamination. The development of easy-to-use and rapid-screening immunoassay methods in a class-selective manner is a topic of considerable environmental interest. In this wo...

Using Emoticons to Encourage Students to Recycle

ERIC Educational Resources Information Center

Meng, Matthew D.; Trudel, Remi

2017-01-01

Uncovering inexpensive, simple techniques to encourage students to act in a pro-environmental manner is of critical importance. Through a four-week field study at a large, environmentally focused elementary school, it was found that placing negatively valenced emoticons (i.e., red frowny faces) on trash cans increased the proportion of recycled…

Land application of organic residuals: Public health threat or environmental benefit

USDA-ARS?s Scientific Manuscript database

Waste residuals consist of manure and biosolids produced by concentrated animal feeding operations and municipal waste water treatment plants. All wastes need to be disposed of in a proper manner, protecting public and environmental health, but also in a sustainable fashion to ensure that no system...

Genetic variability of environmental sensitivity revealed by phenotypic variation in body weight and (its) correlations to physiological and behavioral traits

PubMed Central

Quillet, Edwige; Bégout, Marie-Laure; Aupérin, Benoit; Khaw, Hooi Ling; Millot, Sandie; Valotaire, Claudiane; Kernéis, Thierry; Labbé, Laurent; Prunet, Patrick; Dupont-Nivet, Mathilde

2017-01-01

Adaptive phenotypic plasticity is a key component of the ability of organisms to cope with changing environmental conditions. Fish have been shown to exhibit a substantial level of phenotypic plasticity in response to abiotic and biotic factors. In the present study, we investigate the link between environmental sensitivity assessed globally (revealed by phenotypic variation in body weight) and more targeted physiological and behavioral indicators that are generally used to assess the sensitivity of a fish to environmental stressors. We took advantage of original biological material, the rainbow trout isogenic lines, which allowed the disentangling of the genetic and environmental parts of the phenotypic variance. Ten lines were characterized for the changes of body weight variability (weight measurements taken every month during 18 months), the plasma cortisol response to confinement stress (3 challenges) and a set of selected behavioral indicators. This study unambiguously demonstrated the existence of genetic determinism of environmental sensitivity, with some lines being particularly sensitive to environmental fluctuations and others rather insensitive. Correlations between coefficient of variation (CV) for body weight and behavioral and physiological traits were observed. This confirmed that CV for body weight could be used as an indicator of environmental sensitivity. As the relationship between indicators (CV weight, risk-taking, exploration and cortisol) was shown to be likely depending on the nature and intensity of the stressor, the joint use of several indicators should help to investigate the biological complexity of environmental sensitivity. PMID:29253015

Estimation of genetic variance for macro- and micro-environmental sensitivity using double hierarchical generalized linear models

PubMed Central

2013-01-01

Background Genetic variation for environmental sensitivity indicates that animals are genetically different in their response to environmental factors. Environmental factors are either identifiable (e.g. temperature) and called macro-environmental or unknown and called micro-environmental. The objectives of this study were to develop a statistical method to estimate genetic parameters for macro- and micro-environmental sensitivities simultaneously, to investigate bias and precision of resulting estimates of genetic parameters and to develop and evaluate use of Akaike’s information criterion using h-likelihood to select the best fitting model. Methods We assumed that genetic variation in macro- and micro-environmental sensitivities is expressed as genetic variance in the slope of a linear reaction norm and environmental variance, respectively. A reaction norm model to estimate genetic variance for macro-environmental sensitivity was combined with a structural model for residual variance to estimate genetic variance for micro-environmental sensitivity using a double hierarchical generalized linear model in ASReml. Akaike’s information criterion was constructed as model selection criterion using approximated h-likelihood. Populations of sires with large half-sib offspring groups were simulated to investigate bias and precision of estimated genetic parameters. Results Designs with 100 sires, each with at least 100 offspring, are required to have standard deviations of estimated variances lower than 50% of the true value. When the number of offspring increased, standard deviations of estimates across replicates decreased substantially, especially for genetic variances of macro- and micro-environmental sensitivities. Standard deviations of estimated genetic correlations across replicates were quite large (between 0.1 and 0.4), especially when sires had few offspring. Practically, no bias was observed for estimates of any of the parameters. Using Akaike’s information criterion the true genetic model was selected as the best statistical model in at least 90% of 100 replicates when the number of offspring per sire was 100. Application of the model to lactation milk yield in dairy cattle showed that genetic variance for micro- and macro-environmental sensitivities existed. Conclusion The algorithm and model selection criterion presented here can contribute to better understand genetic control of macro- and micro-environmental sensitivities. Designs or datasets should have at least 100 sires each with 100 offspring. PMID:23827014

Toward a panoramic perspective of the association between environmental factors and cardiovascular disease: An environment-wide association study from National Health and Nutrition Examination Survey 1999-2014.

PubMed

Zhuang, Xiaodong; Guo, Yue; Ni, Ao; Yang, Daya; Liao, Lizhen; Zhang, Shaozhao; Zhou, Huimin; Sun, Xiuting; Wang, Lichun; Wang, Xueqin; Liao, Xinxue

2018-06-04

An environment-wide association study (EWAS) may be useful to comprehensively test and validate associations between environmental factors and cardiovascular disease (CVD) in an unbiased manner. Data from National Health and Nutrition Examination Survey (1999-2014) were randomly 50:50 spilt into training set and testing set. CVD was ascertained by a self-reported diagnosis of myocardial infarction, coronary heart disease or stroke. We performed multiple linear regression analyses associating 203 environmental factors and 132 clinical phenotypes with CVD in training set (false discovery rate < 5%) and significant factors were validated in the testing set (P < 0.05). Random forest (RF) model was used for multicollinearity elimination and variable importance ranking. Discriminative power of factors for CVD was calculated by area under the receiver operating characteristic (AUROC). Overall, 43,568 participants with 4084 (9.4%) CVD were included. After adjusting for age, sex, race, body mass index, blood pressure and socio-economic level, we identified 5 environmental variables and 19 clinical phenotypes associated with CVD in training and testing dataset. Top five factors in RF importance ranking were: waist, glucose, uric acid, and red cell distribution width and glycated hemoglobin. AUROC of the RF model was 0.816 (top 5 factors) and 0.819 (full model). Sensitivity analyses reveal no specific moderators of the associations. Our systematic evaluation provides new knowledge on the complex array of environmental correlates of CVD. These identified correlates may serve as a complementary approach to CVD risk assessment. Our findings need to be probed in further observational and interventional studies. Copyright © 2018. Published by Elsevier Ltd.

Biotunable Nanoplasmonic Filter on Few-Layer MoS2 for Rapid and Highly Sensitive Cytokine Optoelectronic Immunosensing.

PubMed

Park, Younggeun; Ryu, Byunghoon; Oh, Bo-Ram; Song, Yujing; Liang, Xiaogan; Kurabayashi, Katsuo

2017-06-27

Monitoring of the time-varying immune status of a diseased host often requires rapid and sensitive detection of cytokines. Metallic nanoparticle-based localized surface plasmon resonance (LSPR) biosensors hold promise to meet this clinical need by permitting label-free detection of target biomolecules. These biosensors, however, continue to suffer from relatively low sensitivity as compared to conventional immunoassay methods that involve labeling processes. Their response speeds also need to be further improved to enable rapid cytokine quantification for critical care in a timely manner. In this paper, we report an immunobiosensing device integrating a biotunable nanoplasmonic optical filter and a highly sensitive few-layer molybdenum disulfide (MoS 2 ) photoconductive component, which can serve as a generic device platform to meet the need of rapid cytokine detection with high sensitivity. The nanoplasmonic filter consists of anticytokine antibody-conjugated gold nanoparticles on a SiO 2 thin layer that is placed 170 μm above a few-layer MoS 2 photoconductive flake device. The principle of the biosensor operation is based on tuning the delivery of incident light to the few-layer MoS 2 photoconductive flake thorough the nanoplasmonic filter by means of biomolecular surface binding-induced LSPR shifts. The tuning is dependent on cytokine concentration on the nanoplasmonic filter and optoelectronically detected by the few-layer MoS 2 device. Using the developed optoelectronic biosensor, we have demonstrated label-free detection of IL-1β, a pro-inflammatory cytokine, with a detection limit as low as 250 fg/mL (14 fM), a large dynamic range of 10 6 , and a short assay time of 10 min. The presented biosensing approach could be further developed and generalized for point-of-care diagnosis, wearable bio/chemical sensing, and environmental monitoring.

In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases.

PubMed

Mirajkar, Nikita; Pope, Carey N

2008-10-15

Organophosphorus (OP) insecticides elicit toxicity via acetylcholinesterase inhibition, allowing acetylcholine accumulation and excessive stimulation of cholinergic receptors. Some OP insecticides bind to additional macromolecules including butyrylcholinesterase and cholinergic receptors. While neurotoxicity from OP anticholinesterases has been extensively studied, effects on cardiac function have received less attention. We compared the in vitro sensitivity of acetylcholinesterase, butyrylcholinesterase and [(3)H]oxotremorine-M binding to muscarinic receptors in the cortex and heart of adult (3 months) and aging (18 months) rats to chlorpyrifos, methyl parathion and their active metabolites chlorpyrifos oxon and methyl paraoxon. Using selective inhibitors, the great majority of cholinesterase in brain was defined as acetylcholinesterase, while butyrylcholinesterase was the major cholinesterase in heart, regardless of age. In the heart, butyrylcholinesterase was markedly more sensitive than acetylcholinesterase to inhibition by chlorpyrifos oxon, and butyrylcholinesterase in tissues from aging rats was more sensitive than enzyme from adults, possibly due to differences in A-esterase mediated detoxification. Relatively similar differences were noted in brain. In contrast, acetylcholinesterase was more sensitive than butyrylcholinesterase to methyl paraoxon in both heart and brain, but no age-related differences were noted. Both oxons displaced [(3)H]oxotremorine-M binding in heart and brain of both age groups in a concentration-dependent manner. Chlorpyrifos had no effect but methyl parathion was a potent displacer of binding in heart and brain of both age groups. Such OP and age-related differences in interactions with cholinergic macromolecules may be important because of potential for environmental exposures to insecticides as well as the use of anticholinesterases in age-related neurological disorders.

IN VITRO SENSITIVITY OF CHOLINESTERASES AND [3H]OXOTREMORINE-M BINDING IN HEART AND BRAIN OF ADULT AND AGING RATS TO ORGANOPHOSPHORUS ANTICHOLINESTERASES

PubMed Central

Mirajkar, Nikita; Pope, Carey N.

2008-01-01

Organophosphorus (OP) insecticides elicit toxicity via acetylcholinesterase inhibition, allowing acetylcholine accumulation and excessive stimulation of cholinergic receptors. Some OP insecticides bind to additional macromolecules including butyrylcholinesterase and cholinergic receptors. While neurotoxicity from OP anticholinesterases has been extensively studied, effects on cardiac function have received less attention. We compared the in vitro sensitivity of acetylcholinesterase, butyrylcholinesterase and [3H]oxotremorine-M binding to muscarinic receptors in the cortex and heart of adult (3 months) and aging (18 months) rats to chlorpyrifos, methyl parathion and their active metabolites chlorpyrifos oxon and methyl paraoxon. Using selective inhibitors, the great majority of cholinesterase in brain was defined as acetylcholinesterase, while butyrylcholinesterase was the major cholinesterase in heart, regardless of age. In the heart, butyrylcholinesterase was markedly more sensitive than acetylcholinesterase to inhibition by chlorpyrifos oxon, and butyrylcholinesterase in tissues from aging rats was more sensitive than enzyme from adults, possibly due to differences in A-esterase mediated detoxification. Relatively similar differences were noted in brain. In contrast, acetylcholinesterase was more sensitive than butyrylcholinesterase to methyl paraoxon in both heart and brain, but no age-related differences were noted. Both oxons displaced [3H]oxotremorine-M binding in heart and brain of both age groups in a concentration-dependent manner. Chlorpyrifos had no effect but methyl parathion was a potent displacer of binding in heart and brain of both age groups. Such OP and age-related differences in interactions with cholinergic macromolecules may be important because of potential for environmental exposures to insecticides as well as the use of anticholinesterases in age-related neurological disorders. PMID:18761328

Whispering gallery mode resonators based on radiation-sensitive materials

NASA Technical Reports Server (NTRS)

Savchenkov, Anatoliy (Inventor); Maleki, Lutfollah (Inventor); Ilchenko, Vladimir (Inventor); Handley, Timothy A. (Inventor)

2005-01-01

Whispering gallery mode (WGM) optical resonators formed of radiation-sensitive materials to allow for permanent tuning of their resonance frequencies in a controlled manner. Two WGM resonators may be cascaded to form a composite filter to produce a second order filter function where at least one WGM resonator is formed a radiation-sensitive material to allow for proper control in the overlap of the two filter functions.

Sensitization of the Guinea Pig Myocardium through the Mucous Membrane of the Digestive Tract,

DTIC Science & Technology

Under certain conditions, sessile antibodies can be bound by the guinea - pig myocardium that had been sensitized by direct introduction of the allergen into the stomach. This is confirmed by the positive anaphylactic reaction in the isolated heart of animals treated in this manner, which reaction manifests itself in a modified heart rate when the isolated heart is challenged by the sensitizing allergen.

Sfp1 and Rtg3 reciprocally modulate carbon source‐conditional stress adaptation in the pathogenic yeast Candida albicans

PubMed Central

Kastora, Stavroula L.; Herrero‐de‐Dios, Carmen; Avelar, Gabriela M.; Munro, Carol A.

2017-01-01

Summary The pathogenicity of the clinically important yeast, Candida albicans, is dependent on robust responses to host‐imposed stresses. These stress responses have generally been dissected in vitro at 30°C on artificial growth media that do not mimic host niches. Yet host inputs, such as changes in carbon source or temperature, are known to affect C. albicans stress adaptation. Therefore, we performed screens to identify novel regulators that promote stress resistance during growth on a physiologically relevant carboxylic acid and at elevated temperatures. These screens revealed that, under these ‘non‐standard’ growth conditions, numerous uncharacterised regulators are required for stress resistance in addition to the classical Hog1, Cap1 and Cta4 stress pathways. In particular, two transcription factors (Sfp1 and Rtg3) promote stress resistance in a reciprocal, carbon source‐conditional manner. SFP1 is induced in stressed glucose‐grown cells, whereas RTG3 is upregulated in stressed lactate‐grown cells. Rtg3 and Sfp1 regulate the expression of key stress genes such as CTA4, CAP1 and HOG1 in a carbon source‐dependent manner. These mechanisms underlie the stress sensitivity of C. albicans sfp1 cells during growth on glucose, and rtg3 cells on lactate. The data suggest that C. albicans exploits environmentally contingent regulatory mechanisms to retain stress resistance during host colonisation. PMID:28574606

Sensitivity to Peer Evaluation and Its Genetic and Environmental Determinants: Findings from a Population-Based Twin Study.

PubMed

Klippel, Annelie; Reininghaus, Ulrich; Viechtbauer, Wolfgang; Decoster, Jeroen; Delespaul, Philippe; Derom, Cathérine; de Hert, Marc; Jacobs, Nele; Menne-Lothmann, Claudia; Rutten, Bart; Thiery, Evert; van Os, Jim; van Winkel, Ruud; Myin-Germeys, Inez; Wichers, Marieke

2018-02-23

Adolescents and young adults are highly focused on peer evaluation, but little is known about sources of their differential sensitivity. We examined to what extent sensitivity to peer evaluation is influenced by interacting environmental and genetic factors. A sample of 354 healthy adolescent twin pairs (n = 708) took part in a structured, laboratory task in which they were exposed to peer evaluation. The proportion of the variance in sensitivity to peer evaluation due to genetic and environmental factors was estimated, as was the association with specific a priori environmental risk factors. Differences in sensitivity to peer evaluation between adolescents were explained mainly by non-shared environmental influences. The results on shared environmental influences were not conclusive. No impact of latent genetic factors or gene-environment interactions was found. Adolescents with lower self-rated positions on the social ladder or who reported to have been bullied more severely showed significantly stronger responses to peer evaluation. Not genes, but subjective social status and past experience of being bullied seem to impact sensitivity to peer evaluation. This suggests that altered response to peer evaluation is the outcome of cumulative sensitization to social interactions.

The Short Term Effectiveness of an Outdoor Environmental Education on Environmental Awareness and Sensitivity of In-Service Teachers

ERIC Educational Resources Information Center

Okur-Berberoglu, Emel; Ozdilek, Hasan Göksel; Yalcin-Ozdilek, Sükran

2015-01-01

Outdoor education is mostly mentioned in terms of environmental education. The aim of this research is to determine the short term effectiveness of an outdoor environmental education program on biodiversity awareness, environmental awareness and sensitivity to natural environment. The data is collected from an outdoor environmental education…

Sociodemographic and Environmental Correlates of Active Commuting in Rural America

PubMed Central

Fan, Jessie X.; Wen, Ming; Kowaleski-Jones, Lori

2014-01-01

Purpose This research investigated participation rates in 3 modes of active commuting (AC) and their sociodemographic and physical environmental correlates in rural America. Methods The 2000 Census supplemented with other datasets were used to analyze AC rates in percentage of workers walking, biking, and taking public transportations to work in 14,209 nonmetropolitan rural tracts identified by RUCA codes, including 4,067 small rural and 10,142 town-micropolitan rural tracts. Sociodemographic and physical environmental variables were correlated with 3 AC modes simultaneously using Seemingly Unrelated Regression for nonmetro rural, and for small rural and town-micropolitan rural separately. Findings The average AC rates in rural tracts were 3.63%, 0.26%, and 0.56% for walking, biking, and public transportation to work, respectively, with small rural tracts having a higher rate of walking but lower rates of biking and public transportation to work than town-micropolitan tracts. In general, better economic well-being was negatively associated with AC but percentage of college-educated was a positive correlate. Population density was positively associated with AC but greenness and proximity to parks were negative correlates. However, significant differences existed for different AC modes, and between small rural and town-micropolitan rural tracts. Conclusions Sociodemographic factors explained more variance in AC than physical environmental factors but the detailed relationships were complex, varying by AC mode and by degree of rurality. Any strategy to promote AC in rural America needs to be sensitive to the population size of the area and assessed in a comprehensive manner to avoid a “one size fits all” approach. PMID:25066252

Sociodemographic and environmental correlates of active commuting in rural America.

PubMed

Fan, Jessie X; Wen, Ming; Kowaleski-Jones, Lori

2015-01-01

This research investigated participation rates in 3 modes of active commuting (AC) and their sociodemographic and physical environmental correlates in rural America. The 2000 Census supplemented with other data sets were used to analyze AC rates in percentage of workers walking, biking, and taking public transportation to work in 14,209 nonmetropolitan rural tracts identified by RUCA codes, including 4,067 small rural and 10,142 town-micropolitan rural tracts. Sociodemographic and physical environmental variables were correlated with 3 AC modes simultaneously using Seemingly Unrelated Regression for nonmetro rural, and for small rural and town-micropolitan rural separately. The average AC rates in rural tracts were 3.63%, 0.26%, and 0.56% for walking, biking, and public transportation to work, respectively, with small rural tracts having a higher rate of walking but lower rates of biking and public transportation to work than town-micropolitan tracts. In general, better economic well-being was negatively associated with AC but percentage of college-educated was a positive correlate. Population density was positively associated with AC but greenness and proximity to parks were negative correlates. However, significant differences existed for different AC modes, and between small rural and town-micropolitan rural tracts. Sociodemographic factors explained more variance in AC than physical environmental factors but the detailed relationships were complex, varying by AC mode and by degree of rurality. Any strategy to promote AC in rural America needs to be sensitive to the population size of the area and assessed in a comprehensive manner to avoid a "one size fits all" approach. © 2014 National Rural Health Association.

Construction of a Learning Agent Handling Its Rewards According to Environmental Situations

NASA Astrophysics Data System (ADS)

Moriyama, Koichi; Numao, Masayuki

The authors aim at constructing an agent which learns appropriate actions in a Multi-Agent environment with and without social dilemmas. For this aim, the agent must have nonrationality that makes it give up its own profit when it should do that. Since there are many studies on rational learning that brings more and more profit, it is desirable to utilize them for constructing the agent. Therefore, we use a reward-handling manner that makes internal evaluation from the agent's rewards, and then the agent learns actions by a rational learning method with the internal evaluation. If the agent has only a fixed manner, however, it does not act well in the environment with and without dilemmas. Thus, the authors equip the agent with several reward-handling manners and criteria for selecting an effective one for the environmental situation. In the case of humans, what generates the internal evaluation is usually called emotion. Hence, this study also aims at throwing light on emotional activities of humans from a constructive view. In this paper, we divide a Multi-Agent environment into three situations and construct an agent having the reward-handling manners and the criteria. We observe that the agent acts well in all the three Multi-Agent situations composed of homogeneous agents.

Social-Ecological Resilience and Environmental Education: Synopsis, Application, Implications

ERIC Educational Resources Information Center

Plummer, Ryan

2010-01-01

The resilience approach is rooted in ecology and is being advanced as a means to understand change in social-ecological systems. How can resilience be applied to understanding change in social systems, including in environmental education? In probing this question the main resilience approaches are described, the manner in which they may be…

Economics and the Environment - EcoDetectives. EconomicsAmerica.

ERIC Educational Resources Information Center

Schug, Mark C.; Morton, John S.; Wentworth, Donald R.

This book helps middle school and high school students address environmental issues in an intelligent and productive manner. The lessons introduce economic reasoning and show students how to apply it to environmental problems. The 18 lessons are divided into four units addressing: the environment and the economy; incentives; use of market forces…

Green Net Value Added as a Sustainability Metric Based on Life Cycle Assessment: An Application to Bounty® Paper Towel

EPA Science Inventory

Sustainability measurement in economics involves evaluation of environmental and economic impact in an integrated manner. In this study, system level economic data are combined with environmental impact from a life cycle assessment (LCA) of a common product. We are exploring a co...

Applying geologic sensitivity analysis to environmental risk management: The financial implications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, D.T.

The financial risks associated with environmental contamination can be staggering and are often difficult to identify and accurately assess. Geologic sensitivity analysis is gaining recognition as a significant and useful tool that can empower the user with crucial information concerning environmental risk management and brownfield redevelopment. It is particularly useful when (1) evaluating the potential risks associated with redevelopment of historical industrial facilities (brownfields) and (2) planning for future development, especially in areas of rapid development because the number of potential contaminating sources often increases with an increase in economic development. An examination of the financial implications relating to geologicmore » sensitivity analysis in southeastern Michigan from numerous case studies indicate that the environmental cost of contamination may be 100 to 1,000 times greater at a geologically sensitive location compared to the least sensitive location. Geologic sensitivity analysis has demonstrated that near-surface geology may influence the environmental impact of a contaminated site to a greater extent than the amount and type of industrial development.« less

"I've got somebody there, someone cares": what support is most valued following a stroke?

PubMed

Northcott, Sarah; Hilari, Katerina

2017-06-19

There is often a need for increased support following a stroke. This study explored what types of support are provided by different network members and what support functions are most valued. Adults with first stroke were recruited from a stroke unit and participated in in-depth interviews 8-15 months poststroke. Framework Analysis was used to build thematic and explanatory accounts of the data. Twenty-nine participants took part. Main themes to emerge were as follows: the spouse was the most important provider of support; children were a relatively stable source of support, although many participants expressed reservations about worrying a child; relatives and friends typically provided social companionship and emotional support rather than on-going practical support. The only universally valued support function was the sense that someone was concerned and cared. Other valued functions were as follows: social companionship including everyday social "chit chat"; practical support provided sensitively; and, for many, sharing worries and sensitive encouragement. The manner and context in which support was provided was important: support was easiest to receive when it communicated concern, and was part of a reciprocal, caring relationship. As well as measuring supportive acts, researchers and clinicians should consider the manner and context of support. Implications for rehabilitation The manner in which support was provided mattered: support was easier to receive when it communicated concern. The spouse was the most important source of all support functions; children, relatives and friends were important providers of emotional and social companionship support. Researchers and clinicians should not only focus on what support is received, but also the context (e.g., contribution, reciprocity, quality of relationship) and manner (e.g., responsiveness, sensitivity) of the support.

The EPA CompTox Dashboard and Underpinning Software Architecture – a platform for data integration for environmental chemistry data (ACS Fall Meeting 7 of 12)

EPA Science Inventory

The CompTox Dashboard was developed by the Environmental Protection Agency’s National Center for Computational Toxicology. This dashboard has been architected in a manner that allows for the deployment of multiple “applications”, both as publicly available databases, and for dep...

Fostering sustainable operations in a natural resource management agency: insights from the field

Treesearch

Patricia L. Winter; Shawn M. Burn

2010-01-01

Sustainable operations (SO; operating in an environmentally, economically, and socially sustainable manner) is consistent with the environmental stewardship mission of natural resource management organizations. This study sought to examine SO practices in the daily work lives of US Forest Service employees, including those primarily stationed in the office and in the...

Environmentally Based Assessment Practices: Viable Alternatives to Standardized Assessment for Assessing Emergent Literacy Skills in Young Children

ERIC Educational Resources Information Center

Thurman, S. Kenneth; McGrath, Marie C.

2008-01-01

Ecological validity is an important construct in the assessment of young children. The argument is made that using environmentally based assessment practices as well as understanding the child's ecology will help assure that assessments are carried out in an ecologically valid manner. The discussion focuses on play-based assessment,…

Hedonic sensitivity to low-dose ketamine is modulated by gonadal hormones in a sex-dependent manner

PubMed Central

Saland, Samantha K.; Schoepfer, Kristin J.; Kabbaj, Mohamed

2016-01-01

We recently reported a greater sensitivity of female rats to rapid antidepressant-like effects of ketamine compared to male rats, and that ovarian-derived estradiol (E2) and progesterone (P4) are essential for this response. However, to what extent testosterone may also contribute, and whether duration of response to ketamine is modulated in a sex- and hormone-dependent manner remains unclear. To explore this, we systematically investigated the influence of testosterone, estradiol and progesterone on initiation and maintenance of hedonic response to low-dose ketamine (2.5 mg/kg) in intact and gonadectomized male and female rats. Ketamine induced a sustained increase in sucrose preference of female, but not male, rats in an E2P4-dependent manner. Whereas testosterone failed to alter male treatment response, concurrent administration of P4 alone in intact males enhanced hedonic response low-dose ketamine. Treatment responsiveness in female rats only was associated with greater hippocampal BDNF levels, but not activation of key downstream signaling effectors. We provide novel evidence supporting activational roles for ovarian-, but not testicular-, derived hormones in mediating hedonic sensitivity to low-dose ketamine in female and male rats, respectively. Organizational differences may, in part, account for the persistence of sex differences following gonadectomy and selective involvement of BDNF in treatment response. PMID:26888470

Report: Superfund Interagency Agreements

EPA Pesticide Factsheets

Report #2001-P-00011, June 22, 2001. EPA generally had effective controls in place to ensure its Superfund IAGs achieve expected environmental results in a timely, cost-effective, and efficient manner.

Advanced power assessment for Czech lignite, Task 3.6, Part 2. The 2nd international conference on energy and environment: Transitions in East Central Europe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sondreal, E.A.; Mann, M.D.; Weber, G.W.

1995-12-01

On November 1-5, 1994, the Energy & Environmental Research Center (EERC) and Power Research Institute of Prague cosponsored their second conference since 1991 in the Czech Republic, entitled ``Energy and Environment: Transitions in East Central Europe.`` This conference was a continuation of the EERC`s joint commitment, initiated in 1190, to facilitate solutions to short- and long-term energy and environmental problems in East Central Europe. Production of energy from coal in an environmentally acceptable manner is a critical issue facing East Central Europe, because the region continues to rely on coal as its primary energy source. The goal of the conferencemore » was to develop partnerships between industry, government, and the research community in East Central Europe and the United States to solve energy and environmental issues in a manner that fosters economic development. Among the topics addressed at the conference were: conventional and advanced energy generation systems; economic operation of energy systems; air pollution controls; power system retrofitting and repowering, financing options; regulatory issues; energy resource options; waste utilization and disposal; and long-range environmental issues. Selected papers in the proceedings have been processed separately for inclusion in the Energy Science and Technology database.« less

Noise sensitivity: Symptoms, health status, illness behavior and co-occurring environmental sensitivities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baliatsas, Christos, E-mail: c.baliatsas@nivel.nl

Epidemiological evidence on the symptomatic profile, health status and illness behavior of people with subjective sensitivity to noise is still scarce. Also, it is unknown to what extent noise sensitivity co-occurs with other environmental sensitivities such as multi-chemical sensitivity and sensitivity to electromagnetic fields (EMF). A cross-sectional study performed in the Netherlands, combining self-administered questionnaires and electronic medical records of non-specific symptoms (NSS) registered by general practitioners (GP) allowed us to explore this further. The study sample consisted of 5806 participants, drawn from 21 general practices. Among participants, 722 (12.5%) responded “absolutely agree” to the statement “I am sensitive tomore » noise”, comprising the high noise-sensitive (HNS) group. Compared to the rest of the sample, people in the HNS group reported significantly higher scores on number and duration of self-reported NSS, increased psychological distress, decreased sleep quality and general health, more negative symptom perceptions and higher prevalence of healthcare contacts, GP-registered NSS and prescriptions for antidepressants and benzodiazepines. These results remained robust after adjustment for demographic, residential and lifestyle characteristics, objectively measured nocturnal noise exposure from road-traffic and GP-registered morbidity. Co-occurrence rates with other environmental sensitivities varied between 9% and 50%. Individuals with self-declared sensitivity to noise are characterized by high prevalence of multiple NSS, poorer health status and increased illness behavior independently of noise exposure levels. Findings support the notion that different types of environmental sensitivities partly overlap. - Highlights: • People with self-reported noise sensitivity experience multiple non-specific symptoms. • They also report comparatively poorer health and increased illness behavior. • Co-occurrence with other environmental sensitivities is moderate to high. • Road-traffic noise and GP-registered morbidity did not account for these results.« less

Methodology for environmental assessments of oil and hazardous substance spills

NASA Astrophysics Data System (ADS)

Davis, W. P.; Scott, G. I.; Getter, C. D.; Hayes, M. O.; Gundlach, E. R.

1980-03-01

Scientific assessment of the complex environmental consequences of large spills of oil or other hazardous substances has stimulated development of improved strategies for rapid and valid collection and processing of ecological data. The combination of coastal processes and geological measurements developed by Hayes & Gundlach (1978), together with selected field biological and chemical observations/measurements, provide an ecosystem impact assessment approach which is termed “integrated zonal method of ecological impact assessment.” Ecological assessment of oil and hazardous material spills has been divided into three distinct phases: (1) first-order response studies — conducted at the time of the initial spill event, which gather data to document acute impacts and assist decision-makers in prioritization of cleanup efforts and protection of ecologically sensitive habitats, (2) second-order response studies — conducted two months to one year post-spill, which document any delayed mortality and attempt to identify potential sublethal impacts in sensitive species, and (3) third-order response studies — conducted one to three years post-spill, to document chronic impacts (both lethal and sublethal) to specific indicator species. Data collected during first-order response studies are gathered in a quantitative manner so that the initial assessment may become a baseline for later, more detailed, post-spill scientific efforts. First- and second-order response studies of the “Peck Slip” oil spill in Puerto Rico illustrate the usefulness of this method. The need for contingency planning before a spill has been discussed along with the use of the Vulnerability Index, a method in which coastal environments are classified on a scale of 1 10, based upon their potential susceptibility to oiling. A study of the lower Cook Inlet section of the Alaskan coast illustrates the practical application of this method.

Engineering tolerance to industrially relevant stress factors in yeast cell factories.

PubMed

Deparis, Quinten; Claes, Arne; Foulquié-Moreno, Maria R; Thevelein, Johan M

2017-06-01

The main focus in development of yeast cell factories has generally been on establishing optimal activity of heterologous pathways and further metabolic engineering of the host strain to maximize product yield and titer. Adequate stress tolerance of the host strain has turned out to be another major challenge for obtaining economically viable performance in industrial production. Although general robustness is a universal requirement for industrial microorganisms, production of novel compounds using artificial metabolic pathways presents additional challenges. Many of the bio-based compounds desirable for production by cell factories are highly toxic to the host cells in the titers required for economic viability. Artificial metabolic pathways also turn out to be much more sensitive to stress factors than endogenous pathways, likely because regulation of the latter has been optimized in evolution in myriads of environmental conditions. We discuss different environmental and metabolic stress factors with high relevance for industrial utilization of yeast cell factories and the experimental approaches used to engineer higher stress tolerance. Improving stress tolerance in a predictable manner in yeast cell factories should facilitate their widespread utilization in the bio-based economy and extend the range of products successfully produced in large scale in a sustainable and economically profitable way. © FEMS 2017.

Effect of the environmental pollutant bisphenol A dimethacylate (BAD) on Ca2+ movement and viability in OC2 human oral cancer cells.

PubMed

Chien, Jau-Min; Chou, Chiang-Ting; Lu, Yi-Chau; Lu, Ti; Chi, Chao-Chuan; Tseng, Li-Ling; Liu, Shiuh-Inn; Cheng, Jin-Shiung; Kuo, Chun-Chi; Liang, Wei-Zhe; Jan, Chung-Ren

2013-03-01

The environmental pollutant bisphenol A dimethacylate (BAD) has been used as a dental composite. The effect of BAD on cytosolic Ca(2+) concentrations ([Ca(2+)]i) and viability in OC2 human oral cancer cells was explored. The Ca(2+)-sensitive fluorescent dye fura-2 was applied to measure [Ca(2+)]i. BAD induced [Ca(2+)]i rises in a concentration-dependent manner. The response was reduced by removing extracellular Ca(2+). BAD-evoked Ca(2+) entry was suppressed by nifedipine, econazole, and SK&F96365. In Ca(2+)-free medium, incubation with the endoplasmic reticulum Ca(2+) pump inhibitor thapsigargin abolished BAD-induced [Ca(2+)]i rise. Inhibition of phospholipase C with U73122 did not alter BAD-induced [Ca(2+)]i rise. At 10-30μM, BAD inhibited cell viability, which was not reversed by chelating cytosolic Ca(2+). BAD (20-30μM) also induced apoptosis. Collectively, in OC2 cells, BAD induced a [Ca(2+)]i rise by evoking phospholipase C-independent Ca(2+) release from the endoplasmic reticulum and Ca(2+) entry via store-operated Ca(2+) channels. BAD also caused apoptosis. Copyright © 2012 Elsevier B.V. All rights reserved.

Engineering tolerance to industrially relevant stress factors in yeast cell factories

PubMed Central

Deparis, Quinten; Claes, Arne; Foulquié-Moreno, Maria R.

2017-01-01

Abstract The main focus in development of yeast cell factories has generally been on establishing optimal activity of heterologous pathways and further metabolic engineering of the host strain to maximize product yield and titer. Adequate stress tolerance of the host strain has turned out to be another major challenge for obtaining economically viable performance in industrial production. Although general robustness is a universal requirement for industrial microorganisms, production of novel compounds using artificial metabolic pathways presents additional challenges. Many of the bio-based compounds desirable for production by cell factories are highly toxic to the host cells in the titers required for economic viability. Artificial metabolic pathways also turn out to be much more sensitive to stress factors than endogenous pathways, likely because regulation of the latter has been optimized in evolution in myriads of environmental conditions. We discuss different environmental and metabolic stress factors with high relevance for industrial utilization of yeast cell factories and the experimental approaches used to engineer higher stress tolerance. Improving stress tolerance in a predictable manner in yeast cell factories should facilitate their widespread utilization in the bio-based economy and extend the range of products successfully produced in large scale in a sustainable and economically profitable way. PMID:28586408

Ammonia in the atmosphere: a review on emission sources, atmospheric chemistry and deposition on terrestrial bodies.

PubMed

Behera, Sailesh N; Sharma, Mukesh; Aneja, Viney P; Balasubramanian, Rajasekhar

2013-11-01

Gaseous ammonia (NH3) is the most abundant alkaline gas in the atmosphere. In addition, it is a major component of total reactive nitrogen. The largest source of NH3 emissions is agriculture, including animal husbandry and NH3-based fertilizer applications. Other sources of NH3 include industrial processes, vehicular emissions and volatilization from soils and oceans. Recent studies have indicated that NH3 emissions have been increasing over the last few decades on a global scale. This is a concern because NH3 plays a significant role in the formation of atmospheric particulate matter, visibility degradation and atmospheric deposition of nitrogen to sensitive ecosystems. Thus, the increase in NH3 emissions negatively influences environmental and public health as well as climate change. For these reasons, it is important to have a clear understanding of the sources, deposition and atmospheric behaviour of NH3. Over the last two decades, a number of research papers have addressed pertinent issues related to NH3 emissions into the atmosphere at global, regional and local scales. This review article integrates the knowledge available on atmospheric NH3 from the literature in a systematic manner, describes the environmental implications of unabated NH3 emissions and provides a scientific basis for developing effective control strategies for NH3.

In utero and postnatal exposure to arsenic alters pulmonary structure and function

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lantz, R. Clark; Southwest Environmental Health Science Center, University of Arizona, Tucson, AZ 85721; BIO5 Institute, University of Arizona, Tucson, AZ 85721

2009-02-15

In addition to cancer endpoints, arsenic exposures can also lead to non-cancerous chronic lung disease. Exposures during sensitive developmental time points can contribute to the adult disease. Using a mouse model, in utero and early postnatal exposures to arsenic (100 ppb or less in drinking water) were found to alter airway reactivity to methacholine challenge in 28 day old pups. Removal of mice from arsenic exposure 28 days after birth did not reverse the alterations in sensitivity to methacholine. In addition, adult mice exposed to similar levels of arsenic in drinking water did not show alterations. Therefore, alterations in airwaymore » reactivity were irreversible and specific to exposures during lung development. These functional changes correlated with protein and gene expression changes as well as morphological structural changes around the airways. Arsenic increased the whole lung levels of smooth muscle actin in a dose dependent manner. The level of smooth muscle mass around airways was increased with arsenic exposure, especially around airways smaller than 100 {mu}m in diameter. This increase in smooth muscle was associated with alterations in extracellular matrix (collagen, elastin) expression. This model system demonstrates that in utero and postnatal exposure to environmentally relevant levels of arsenic can irreversibly alter pulmonary structure and function in the adults.« less

Guidance Manual for Integrating Hazardous Material Control and Management into System Acquisition Programs

DTIC Science & Technology

1993-04-01

34 in the remainder of this "• IPS. Ensure that system safety, Section refer to the DoD format paragraph health hazards, and environmental for the...hazardous materials is controlled in the manner which protects human health and the environment at the least cost. Hazardous Material Control and Management...of hazardous materials is controlled in a manner which protects human health and the environment at the least cost. Hazardous Material Control and

Planning and Implementing a Graduate Environmental Science Course: A State Agency and a University Partnership.

ERIC Educational Resources Information Center

Wiggins, Felita

The Texas Natural Resource Conservation Commission (TNRCC) is the lead environmental agency for the State of Texas. It's charged is to oversee Texas natural resources: air, water, and waste management. The challenge is to manage these resources in a manner so that air and water are sustainable for the future and waste management is dealt with…

Surface Acoustic Wave Nebulisation Mass Spectrometry for the Fast and Highly Sensitive Characterisation of Synthetic Dyes in Textile Samples

NASA Astrophysics Data System (ADS)

Astefanei, Alina; van Bommel, Maarten; Corthals, Garry L.

2017-10-01

Surface acoustic wave nebulisation (SAWN) mass spectrometry (MS) is a method to generate gaseous ions compatible with direct MS of minute samples at femtomole sensitivity. To perform SAWN, acoustic waves are propagated through a LiNbO3 sampling chip, and are conducted to the liquid sample, which ultimately leads to the generation of a fine mist containing droplets of nanometre to micrometre diameter. Through fission and evaporation, the droplets undergo a phase change from liquid to gaseous analyte ions in a non-destructive manner. We have developed SAWN technology for the characterisation of organic colourants in textiles. It generates electrospray-ionisation-like ions in a non-destructive manner during ionisation, as can be observed by the unmodified chemical structure. The sample size is decreased by tenfold to 1000-fold when compared with currently used liquid chromatography-MS methods, with equal or better sensitivity. This work underscores SAWN-MS as an ideal tool for molecular analysis of art objects as it is non-destructive, is rapid, involves minimally invasive sampling and is more sensitive than current MS-based methods. [Figure not available: see fulltext.

Environmental projects. Volume 6: Environmental assessment. New 34-meter antenna at Venus site

NASA Technical Reports Server (NTRS)

Kushner, L.

1988-01-01

The Jet Propulsion Lab has proposed replacing the 26-meter antenna at the Venus Station of the Goldstone Deep Space Communications Complex with a new 34-meter antenna. An environmental impact assessment of this proposed change is presented. It is concluded that the proposed antenna and its operation would not result in significant adverse impacts to the physical or human environment. It will, however, be necessary to manage electromagnetic transmissions from the antenna in such a manner as to ensure safe operation.

The Utility of Behavioral Economics in Expanding the Free-Feed Model of Obesity

PubMed Central

Rasmussen, Erin B.; Robertson, Stephen H.; Rodriguez, Luis R.

2016-01-01

Animal models of obesity are numerous and diverse in terms of identifying specific neural and peripheral mechanisms related to obesity; however, they are limited when it comes to behavior. The standard behavioral measure of food intake in most animal models occurs in a free-feeding environment. While easy and cost-effective for the researcher, the free-feeding environment omits some of the most important features of obesity-related food consumption—namely, properties of food availability, such as effort and delay to obtaining food. Behavior economics expands behavioral measures of obesity animal models by identifying such behavioral mechanisms. First, economic demand analysis allows researchers to understand the role of effort in food procurement, and how physiological and neural mechanisms are related. Second, studies on delay discounting contribute to a growing literature that shows that sensitivity to delayed food- and food-related outcomes is likely a fundamental process of obesity. Together, these data expand the animal model in a manner that better characterizes how environmental factors influence food consumption. PMID:26923097

"Orange alert": a fluorescent detector for bisphenol A in water environments.

PubMed

Zhang, Liyun; Er, Jun Cheng; Xu, Wang; Qin, Xian; Samanta, Animesh; Jana, Santanu; Lee, Chi-Lik Ken; Chang, Young-Tae

2014-03-07

Due to the prevalent use of polycarbonate plastics and epoxy resins in packaging materials and paints for ships, there has been a widespread global contamination of environmental water sources with bisphenol A (BPA). BPA, an endocrine disruptor, has been found to cause tremendous health problems. Therefore, there is an urgent need for detecting BPA in a convenient and sensitive manner to ensure water safety. Herein, we develop a fluorescent turn-on BPA probe, named Bisphenol Orange (BPO), which could conveniently detect BPA in a wide variety of real water samples including sea water, drain water and drinking water. BPO shows superior selectivity toward BPA and up to 70-fold increase in fluorescence emission at 580 nm when mixed with BPA in water. Mechanistic studies suggest a plausible water-dependent formation of hydrophobic BPA clusters which favorably trap and restrict the rotation of BPO and recover its inherent fluorescence. Copyright © 2014 Elsevier B.V. All rights reserved.

Microencapsulation in Alginate and Chitosan Microgels to Enhance Viability of Bifidobacterium longum for Oral Delivery

PubMed Central

Yeung, Timothy W.; Üçok, Elif F.; Tiani, Kendra A.; McClements, David J.; Sela, David A.

2016-01-01

Probiotic microorganisms are incorporated into a wide variety of foods, supplements, and pharmaceuticals to promote human health and wellness. However, maintaining bacterial cell viability during storage and gastrointestinal transit remains a challenge. Encapsulation of bifidobacteria within food-grade hydrogel particles potentially mitigates their sensitivity to environmental stresses. In this study, Bifidobacterium longum subspecies and strains were encapsulated in core-shell microgels consisting of an alginate core and a microgel shell. Encapsulated obligate anaerobes Bifidobacterium longum subsp. infantis and Bifidobacterium longum subsp. longum exhibited differences in viability in a strain-dependent manner, without a discernable relationship to subspecies lineage. This includes viability under aerobic storage conditions and modeled gastrointestinal tract conditions. Coating alginate microgels with chitosan did not improve viability compared to cells encapsulated in alginate microgels alone, suggesting that modifying the surface charge alone does not enhance delivery. Thus hydrogel beads have great potential for improving the stability and efficacy of bifidobacterial probiotics in various nutritional interventions. PMID:27148184

Testing the genotoxicity of coking wastewater using Vicia faba and Hordeum vulgare bioassays.

PubMed

Dong, Yiru; Zhang, Jintun

2010-07-01

The coking wastewater induces severe environmental problems in China, however, its toxicity has not been well known. In the present study, the genotoxicity of coking wastewater was studied using Vicia faba and Hordeum vulgare root tip cytogenetic bioassays. Results show that the tested coking wastewater decreased the mitotic index, and significantly enhanced the frequencies of micronucleus, sister chromatid exchange and pycnotic cell in concentration-dependent manners. Exposure to the same concentration wastewater, the increasing ratios of above genetic injuries were higher in V. faba than that in H. vulgare. The results imply that coking wastewater is a genotoxic agent in plant cells and exposure to the wastewater in environment may pose a potential genotoxic risk to organisms. It also suggests that both bioassays can be used for testing the genotoxicity of coking wastewater, but the V. faba assay is more sensitive than H. vulgare assay during the process. Copyright (c) 2010. Published by Elsevier Inc.

Rapid Estrogen Receptor-Mediated Mechanisms Determine the Sexually Dimorphic Sensitivity of Ventricular Myocytes to 17β-Estradiol and the Environmental Endocrine Disruptor Bisphenol A

PubMed Central

Belcher, Scott M.; Chen, Yamei; Yan, Sujuan

2012-01-01

Previously we showed that 17β-estradiol (E2) and/or the xenoestrogen bisphenol A (BPA) alter ventricular myocyte Ca2+ handing, resulting in increased cardiac arrhythmias in a female-specific manner. In the present study, the roles of estrogen receptors (ER) in mediating the rapid contractile and arrhythmogenic effects of estrogens were examined. Contractility was used as an index to assess the impact of E2 or BPA on Ca2+ handling in rodent ventricular myocytes. The concentration-response curve for the stimulatory effects of BPA and E2 on female myocyte was inverted-U shaped. Detectable effects for each compound were observed at 10−12 m, and the most efficacious concentrations for each were at 10−9 m. Sensitivity to E2 and BPA was not observed in male myocytes and was abolished in myocytes from ovariectomized females. Analysis using protein-conjugated E2 suggests that these rapid actions are induced by membrane-associated receptors. Analysis using selective ER agonists and antagonists and a genetic ERβ knockout mouse model showed that ERα and ERβ have opposing actions in myocytes and that the balance between ERβ and ERα signaling is the prime regulator of the sex-specific sensitivity toward estrogens. The response of female myocytes to E2 and BPA is dominated by the stimulatory ERβ-mediated signaling, and the absence of BPA and E2 responsiveness in males is due to a counterbalancing-suppressive action of ERα. We conclude that the sex-specific sensitivity of myocytes to estrogens and the rapid arrhythmogenic effects of BPA and estradiol in the female heart are regulated by the balance between ERα and ERβ signaling. PMID:22166976

Defect-engineered graphene chemical sensors with ultrahigh sensitivity.

PubMed

Lee, Geonyeop; Yang, Gwangseok; Cho, Ara; Han, Jeong Woo; Kim, Jihyun

2016-05-25

We report defect-engineered graphene chemical sensors with ultrahigh sensitivity (e.g., 33% improvement in NO2 sensing and 614% improvement in NH3 sensing). A conventional reactive ion etching system was used to introduce the defects in a controlled manner. The sensitivity of graphene-based chemical sensors increased with increasing defect density until the vacancy-dominant region was reached. In addition, the mechanism of gas sensing was systematically investigated via experiments and density functional theory calculations, which indicated that the vacancy defect is a major contributing factor to the enhanced sensitivity. This study revealed that defect engineering in graphene has significant potential for fabricating ultra-sensitive graphene chemical sensors.

36 CFR 1008.6 - Assuring integrity of records.

Code of Federal Regulations, 2012 CFR

2012-07-01

... shall be maintained in a secure manner commensurate with the sensitivity of the information contained in the system of records. The Privacy Act Officer will periodically review these security measures to...

36 CFR 1008.6 - Assuring integrity of records.

Code of Federal Regulations, 2011 CFR

2011-07-01

... shall be maintained in a secure manner commensurate with the sensitivity of the information contained in the system of records. The Privacy Act Officer will periodically review these security measures to...

36 CFR 1008.6 - Assuring integrity of records.

Code of Federal Regulations, 2014 CFR

2014-07-01

... shall be maintained in a secure manner commensurate with the sensitivity of the information contained in the system of records. The Privacy Act Officer will periodically review these security measures to...

Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro.

PubMed

Pěnčíková, Kateřina; Brenerová, Petra; Svržková, Lucie; Hrubá, Eva; Pálková, Lenka; Vondráček, Jan; Lehmler, Hans-Joachim; Machala, Miroslav

2017-11-09

PCB 136 is an environmentally relevant chiral PCB congener, which has been found in vivo to be present in form of rotational isomers (atropisomers). Its atropselective biotransformation or neurotoxic effects linked with sensitization of ryanodine receptor suggest that it might interact also with other intracellular receptors in a stereospecific manner. However, possible atropselective effects of PCB 136 on nuclear receptor transactivation remain unknown. Therefore, in this study, atropselective effects of PCB 136 on nuclear receptors controlling endocrine signaling and/or expression of xenobiotic and steroid hormone catabolism were investigated. PCB136 atropisomers were found to exert differential effects on estrogen receptor (ER) activation; (+)-PCB 136 was estrogenic, while (-)-PCB 136 was antiestrogenic. In contrast, inhibition of androgen receptor (AR) activity was not stereospecific. Both PCB136 stereoisomers induced the constitutive androgen receptor (CAR)-dependent gene expression; however, no significant stereospecificity of PCB 136 atropisomers was observed. PCB136 was a partial inducer of the pregnane X receptor (PXR)-dependent gene expression. Here, (-)-PCB 136 was a significantly more potent inducer of PXR activity than (+)-PCB 136. Taken together, the present results indicate that at least two nuclear receptors participating in endocrine regulation or metabolism, ER and PXR, could be regulated in an atropselective manner by chiral PCB 136. The enantioselective enrichment of PCB atropisomers in animal and human tissues may thus have significant consequences for endocrine-disrupting effects of chiral ortho-substituted PCB congeners.

In vitro effects of diethylstilbestrol, genistein, 4-tert-butylphenol, and 4-tert-octylphenol on steroidogenic activity of isolated immature rat ovarian follicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Myllymaeki, Sari; Haavisto, Tapio; Vainio, Minna

2005-04-01

Isolated rat ovarian follicles grow and produce steroid hormones in vitro and so provide a good model for studying the effects of hormonally active compounds on follicular steroidogenesis. We have evaluated the effects of diethylstilbestrol (DES), genistein (GEN) and two alkylphenols, 4-tert-butylphenol (BP) and 4-tert-octylphenol (OP) on the growth, survival, and steroid hormone and cAMP production by isolated 14-day-old rat (Sprague-Dawley) ovarian follicles. During a 5-day culture, FSH was obligatory for follicle growth and increased estradiol and testosterone secretion in a dose-dependent manner. DES (10{sup -6} M) caused the strongest decline in estradiol and testosterone levels but did not havemore » detectable effects on either cAMP production or aromatase enzyme activity. GEN caused a prominent decrease in cAMP and testosterone levels without significant changes in secreted estradiol. The latter, apparently, was due to a dose-dependent stimulation of aromatase enzyme activity in the presence of genistein. Both BP and OP decreased estradiol and testosterone secretion in a dose-dependent manner while no effect on aromatase activity was observed. OP, unlike BP, decreased forskolin-induced cAMP levels. Xenoestrogens at the used concentrations did not interfere with the growth and survival of the follicles. The results indicate that isolated ovarian follicles representing intact morphological and functional units offer a sensitive model system for elucidating the female-specific reproductive effects of environmental chemicals.« less

Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study.

PubMed

Keers, Robert; Pluess, Michael

2017-12-01

While environmental adversity has been shown to increase risk for psychopathology, individuals differ in their sensitivity to these effects. Both genes and childhood experiences are thought to influence sensitivity to the environment, and these factors may operate synergistically such that the effects of childhood experiences on later sensitivity are greater in individuals who are more genetically sensitive. In line with this hypothesis, several recent studies have reported a significant three-way interaction (Gene × Environment × Environment) between two candidate genes and childhood and adult environment on adult psychopathology. We aimed to replicate and extend these findings in a large, prospective multiwave longitudinal study using a polygenic score of environmental sensitivity and objectively measured childhood and adult material environmental quality. We found evidence for both Environment × Environment and Gene × Environment × Environment effects on psychological distress. Children with a poor-quality material environment were more sensitive to the negative effects of a poor environment as adults, reporting significantly higher psychological distress scores. These effects were further moderated by a polygenic score of environmental sensitivity. Genetically sensitive children were more vulnerable to adversity as adults, if they had experienced a poor childhood environment but were significantly less vulnerable if their childhood environment was positive. These findings are in line with the differential susceptibility hypothesis and suggest that a life course approach is necessary to elucidate the role of Gene × Environment in the development of mental illnesses.

Examination of Acute Sensitivity to Morphine and Morphine Self-Administration Following Physical and Environmental Stressors in Fischer-344 and Lewis Female Rats

DTIC Science & Technology

1997-01-16

Administration Following Physical and Environmental Stressors in Fischer-344 and Lewis Female Rats" Name of Candidate: Kelly Brown Doctor...Title ofDissertation: Examination ofAcute Sensitivity to Morphine and Morphine Self- Administration Following Physical and Environmental Stressors in...to tolerance, toxicity, or addiction liability. IV Examination ofAcute Sensitivity to Morphine and Morphine Self-Administration Following Physical and

Drinking Water: Health Hazards Still Not Resolved

ERIC Educational Resources Information Center

Wade, Nicholas

1977-01-01

Despite the suggested link between cancer deaths and drinking obtained from the Mississippi River, New Orleans still treats its water supply in the same manner as before the Environmental Defense Fund's epidemiological study. (BT)

Electrochemical Methodologies for the Detection of Pathogens.

PubMed

Amiri, Mandana; Bezaatpour, Abolfazl; Jafari, Hamed; Boukherroub, Rabah; Szunerits, Sabine

2018-05-25

Bacterial infections remain one of the principal causes of morbidity and mortality worldwide. The number of deaths due to infections is declining every year by only 1% with a forecast of 13 million deaths in 2050. Among the 1400 recognized human pathogens, the majority of infectious diseases is caused by just a few, about 20 pathogens only. While the development of vaccinations and novel antibacterial drugs and treatments are at the forefront of research, and strongly financially supported by policy makers, another manner to limit and control infectious outbreaks is targeting the development and implementation of early warning systems, which indicate qualitatively and quantitatively the presence of a pathogen. As toxin contaminated food and drink are a potential threat to human health and consequently have a significant socioeconomic impact worldwide, the detection of pathogenic bacteria remains not only a big scientific challenge but also a practical problem of enormous significance. Numerous analytical methods, including conventional culturing and staining techniques as well as molecular methods based on polymerase chain reaction amplification and immunological assays, have emerged over the years and are used to identify and quantify pathogenic agents. While being highly sensitive in most cases, these approaches are highly time, labor, and cost consuming, requiring trained personnel to perform the frequently complex assays. A great challenge in this field is therefore to develop rapid, sensitive, specific, and if possible miniaturized devices to validate the presence of pathogens in cost and time efficient manners. Electrochemical sensors are well accepted powerful tools for the detection of disease-related biomarkers and environmental and organic hazards. They have also found widespread interest in the last years for the detection of waterborne and foodborne pathogens due to their label free character and high sensitivity. This Review is focused on the current electrochemical-based microorganism recognition approaches and putting them into context of other sensing devices for pathogens such as culturing the microorganism on agar plates and the polymer chain reaction (PCR) method, able to identify the DNA of the microorganism. Recent breakthroughs will be highlighted, including the utilization of microfluidic devices and immunomagnetic separation for multiple pathogen analysis in a single device. We will conclude with some perspectives and outlooks to better understand shortcomings. Indeed, there is currently no adequate solution that allows the selective and sensitive binding to a specific microorganism, that is fast in detection and screening, cheap to implement, and able to be conceptualized for a wide range of biologically relevant targets.

36 CFR § 1008.6 - Assuring integrity of records.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Privacy Act shall be maintained in a secure manner commensurate with the sensitivity of the information contained in the system of records. The Privacy Act Officer will periodically review these security measures...

Conceptualizations of Waste-Related Implications on Health and Welfare among Elementary School Students in the Negev's Bedouin Arab Community

ERIC Educational Resources Information Center

Sedawi, Wisam; Ben Zvi Assaraf, Orit; Cwikel, Julie

2014-01-01

This study addresses the manner in which 4th-5th grade children from unrecognized Bedouin settlements in Israel's Negev desert perceive waste and its effects on health and the environment, with an eye towards building a future model for their environmental education. These children participate in local practices with environmental repercussions,…

SENSITIVITY ANALYSIS OF AGGREGATED ENVIRONMENTAL INDICES WITH A CASE-STUDY OF THE MID-ATLANTIC REGION

EPA Science Inventory

Environmental indicators are often aggregated into a single index for various purposes in environmental studies. Aggregated indices derived from the same data set can differ, usually because the aggregated indices' sensitivities are not thoroughly analyzed. Furthermore, if a sens...

Eating high fat chow enhances the locomotor-stimulating effects of cocaine in adolescent and adult female rats.

PubMed

Baladi, Michelle G; Koek, Wouter; Aumann, Megan; Velasco, Fortino; France, Charles P

2012-08-01

Dopamine systems vary through development in a manner that can impact drugs acting on those systems. Dietary factors can also impact the effects of drugs acting on dopamine systems. This study examined whether eating high fat chow alters locomotor effects of cocaine (1-56 mg/kg) in adolescent and adult female rats. Cocaine was studied in rats (n = 6/group) with free access to standard (5.7% fat) or high fat (34.3%) chow or restricted access to high fat chow (body weight matched to rats eating standard chow). After 1 week of eating high fat chow (free or restricted access), sensitivity to cocaine was significantly increased in adolescent and adult rats, compared with rats eating standard chow. Sensitivity to cocaine was also increased in adolescent rats with restricted, but not free, access to high fat chow for 4 weeks. When adolescent and adult rats that previously ate high fat chow ate standard chow, sensitivity to cocaine returned to normal. In adolescent and adult female rats eating high fat chow, but not those eating standard chow, sensitivity to cocaine increased progressively over once weekly tests with cocaine (i.e., sensitization) in a manner that was not statistically different between adolescents and adults. These results show that eating high fat chow alters sensitivity of female rats to acutely administered cocaine and also facilitates the development of sensitization to cocaine. That the type of food consumed can increase drug effects might have relevance to vulnerability to abuse cocaine in the female population.

Vantage sensitivity: a framework for individual differences in response to psychological intervention.

PubMed

de Villiers, Bernadette; Lionetti, Francesca; Pluess, Michael

2018-06-01

People differ significantly in their response to psychological intervention, with some benefitting more from treatment than others. According to the recently proposed theoretical framework of vantage sensitivity, some of this variability may be due to individual differences in environmental sensitivity, the inherent ability to register, and process external stimuli. In this paper, we apply the vantage sensitivity framework to the field of psychiatry and clinical psychology, proposing that some people are more responsive to the positive effects of psychological intervention due to heightened sensitivity. After presenting theoretical frameworks related to environmental sensitivity, we review a selection of recent studies reporting individual differences in the positive response to psychological intervention. A growing number of studies report that some people benefit more from psychological intervention than others as a function of genetic, physiological, and psychological characteristics. These studies support the vantage sensitivity proposition that treatment response is influenced by factors associated with heightened sensitivity to environmental influences. More recently, studies have also shown that sensitivity can be measured with a short questionnaire which appears to predict the response to psychological intervention. Vantage sensitivity is a framework with significant relevance for our understanding of widely observed heterogeneity in treatment response. It suggests that variability in response to treatment is partly influenced by people's differing capacity for environmental sensitivity, which can be measured with a short questionnaire. Application of the vantage sensitivity framework to psychiatry and clinical psychology may improve our knowledge regarding when, how, and for whom interventions work.

Yield stability of processing sweet corn and relationship to genotype adoption

USDA-ARS?s Scientific Manuscript database

Yield stability is a crop genotype’s performance over a range of environmental conditions, such that a specific genotype may be less sensitive to environmental change (i.e. above-average stability) or more sensitive to environmental change (i.e. below-average stability) relative to other genotypes. ...

Documenting Ground-Water Modeling at Sites Contaminated with Radioactive Substances

EPA Pesticide Factsheets

This report is the product of the Interagency Environmental Pathway Modeling Working Group. This report demonstrates how to document model applications in a consistent manner and is intended to assist technical staff.

WEDDS: The WITS Encrypted Data Delivery System

NASA Technical Reports Server (NTRS)

Norris, J.; Backes, P.

1999-01-01

WEDDS, the WITS Encrypted Data Delivery System, is a framework for supporting distributed mission operations by automatically transferring sensitive mission data in a secure and efficient manner to and from remote mission participants over the internet.

Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner.

PubMed

Fernandes, Elizabeth S; Russell, Fiona A; Alawi, Khadija M; Sand, Claire; Liang, Lihuan; Salamon, Robin; Bodkin, Jennifer V; Aubdool, Aisah A; Arno, Matthew; Gentry, Clive; Smillie, Sarah-Jane; Bevan, Stuart; Keeble, Julie E; Malcangio, Marzia; Brain, Susan D

2016-01-11

The effect of cold temperature on arthritis symptoms is unclear. The aim of this study was to investigate how environmental cold affects pain and blood flow in mono-arthritic mice, and examine a role for transient receptor potential ankyrin 1 (TRPA1), a ligand-gated cation channel that can act as a cold sensor. Mono-arthritis was induced by unilateral intra-articular injection of complete Freund's adjuvant (CFA) in CD1 mice, and in mice either lacking TRPA1 (TRPA1 KO) or respective wildtypes (WT). Two weeks later, nociception and joint blood flow were measured following exposure to 10 °C (1 h) or room temperature (RT). Primary mechanical hyperalgesia in the knee was measured by pressure application apparatus; secondary mechanical hyperalgesia by automated von Frey system; thermal hyperalgesia by Hargreaves technique, and weight bearing by the incapacitance test. Joint blood flow was recorded by full-field laser perfusion imager (FLPI) and using clearance of (99m)Technetium. Blood flow was assessed after pretreatment with antagonists of either TRPA1 (HC-030031), substance P neurokinin 1 (NK1) receptors (SR140333) or calcitonin gene-related peptide (CGRP) (CGRP8-37). TRPA1, TAC-1 and CGRP mRNA levels were examined in dorsal root ganglia, synovial membrane and patellar cartilage samples. Cold exposure caused bilateral primary mechanical hyperalgesia 2 weeks after CFA injection, in a TRPA1-dependent manner. In animals maintained at RT, clearance techniques and FLPI showed that CFA-treated joints exhibited lower blood flow than saline-treated joints. In cold-exposed animals, this reduction in blood flow disappears, and increased blood flow in the CFA-treated joint is observed using FLPI. Cold-induced increased blood flow in CFA-treated joints was blocked by HC-030031 and not observed in TRPA1 KOs. Cold exposure increased TRPA1 mRNA levels in patellar cartilage, whilst reducing it in synovial membranes from CFA-treated joints. We provide evidence that environmental cold exposure enhances pain and increases blood flow in a mono-arthritis model. These changes are dependent on TRPA1. Thus, TRPA1 may act locally within the joint to influence blood flow via sensory nerves, in addition to its established nociceptive actions.

Optimal reconstruction of historical water supply to a distribution system: A. Methodology.

PubMed

Aral, M M; Guan, J; Maslia, M L; Sautner, J B; Gillig, R E; Reyes, J J; Williams, R C

2004-09-01

The New Jersey Department of Health and Senior Services (NJDHSS), with support from the Agency for Toxic Substances and Disease Registry (ATSDR) conducted an epidemiological study of childhood leukaemia and nervous system cancers that occurred in the period 1979 through 1996 in Dover Township, Ocean County, New Jersey. The epidemiological study explored a wide variety of possible risk factors, including environmental exposures. ATSDR and NJDHSS determined that completed human exposure pathways to groundwater contaminants occurred in the past through private and community water supplies (i.e. the water distribution system serving the area). To investigate this exposure, a model of the water distribution system was developed and calibrated through an extensive field investigation. The components of this water distribution system, such as number of pipes, number of tanks, and number of supply wells in the network, changed significantly over a 35-year period (1962--1996), the time frame established for the epidemiological study. Data on the historical management of this system was limited. Thus, it was necessary to investigate alternative ways to reconstruct the operation of the system and test the sensitivity of the system to various alternative operations. Manual reconstruction of the historical water supply to the system in order to provide this sensitivity analysis was time-consuming and labour intensive, given the complexity of the system and the time constraints imposed on the study. To address these issues, the problem was formulated as an optimization problem, where it was assumed that the water distribution system was operated in an optimum manner at all times to satisfy the constraints in the system. The solution to the optimization problem provided the historical water supply strategy in a consistent manner for each month of the study period. The non-uniqueness of the selected historical water supply strategy was addressed by the formulation of a second model, which was based on the first solution. Numerous other sensitivity analyses were also conducted using these two models. Both models are solved using a two-stage progressive optimality algorithm along with genetic algorithms (GAs) and the EPANET2 water distribution network solver. This process reduced the required solution time and generated a historically consistent water supply strategy for the water distribution system.

A multivariate twin study of trait mindfulness, depressive symptoms, and anxiety sensitivity.

PubMed

Waszczuk, Monika A; Zavos, Helena M S; Antonova, Elena; Haworth, Claire M; Plomin, Robert; Eley, Thalia C

2015-04-01

Mindfulness-based therapies have been shown to be effective in treating depression and reducing cognitive biases. Anxiety sensitivity is one cognitive bias that may play a role in the association between mindfulness and depressive symptoms. It refers to an enhanced sensitivity toward symptoms of anxiety, with a belief that these are harmful. Currently, little is known about the mechanisms underpinning the association between mindfulness, depression, and anxiety sensitivity. The aim of this study was to examine the role of genetic and environmental factors in trait mindfulness, and its genetic and environmental overlap with depressive symptoms and anxiety sensitivity. Over 2,100 16-year-old twins from a population-based study rated their mindfulness, depressive symptoms, and anxiety sensitivity. Twin modeling analyses revealed that mindfulness is 32% heritable and 66% due to nonshared environmental factors, with no significant influence of shared environment. Genetic influences explained over half of the moderate phenotypic associations between low mindfulness, depressive symptoms, and anxiety sensitivity. About two-thirds of genetic influences and almost all nonshared environmental influences on mindfulness were independent of depression and anxiety sensitivity. This is the first study to show that both genes and environment play an important role in the etiology of mindfulness in adolescence. Future research should identify the specific environmental factors that influence trait mindfulness during development to inform targeted treatment and resilience interventions. Shared genetic liability underpinning the co-occurrence of low mindfulness, depression, and anxiety sensitivity suggests that the biological pathways shared between these traits should also be examined. © 2015 The Authors. Depression and Anxiety published by Wiley Periodicals, Inc.

Effects of time delay and pitch control sensitivity in the flared landing

NASA Technical Reports Server (NTRS)

Berthe, C. J.; Chalk, C. R.; Wingarten, N. C.; Grantham, W.

1986-01-01

Between December 1985 and January 1986, a flared landing program was conducted, using the USAF Total In-Flight simulator airplane, to examine time delay effects in a formal manner. Results show that as pitch sensitivity is increased, tolerance to time delay decreases. With the proper selection of pitch sensitivity, Level I performance was maintained with time delays ranging from 150 milliseconds to greater than 300 milliseconds. With higher sensitivity, configurations with Level I performance at 150 milliseconds degraded to level 2 at 200 milliseconds. When metrics of time delay and pitch sensitivity effects are applied to enhance previously developed predictive criteria, the result is an improved prediction technique which accounts for significant closed loop items.

Identification of Microcystis aeruginosa Peptides Responsible for Allergic Sensitization and Characterization of Functional Interactions between Cyanobacterial Toxins and Immunogenic Peptides

PubMed Central

Geh, Esmond N.; Ghosh, Debajyoti; McKell, Melanie; de la Cruz, Armah A.; Stelma, Gerard

2015-01-01

Background The cyanobacterium species Microcystis aeruginosa produces microcystin and an array of diverse metabolites believed responsible for their toxicity and/or immunogenicity. Previously, chronic rhinitis patients were demonstrated to elicit a specific IgE response to nontoxic strains of M. aeruginosa by skin-prick testing, indicating that cyanobacteria allergenicity resides in a non-toxin–producing component of the organism. Objectives We sought to identify and characterize M. aeruginosa peptide(s) responsible for allergic sensitization in susceptible individuals, and we investigated the functional interactions between cyanobacterial toxins and their coexpressed immunogenic peptides. Methods Sera from patients and extracts from M. aeruginosa toxic [MC(+)] and nontoxic [MC(–)] strains were used to test IgE-specific reactivity by direct and indirect ELISAs; 2D gel electrophoresis, followed by immunoblots and mass spectrometry (MS), was performed to identify the relevant sensitizing peptides. Cytotoxicity and mediator release assays were performed using the MC(+) and MC(–) lysates. Results We found specific IgE to be increased more in response to the MC(–) strain than the MC(+) strain. This response was inhibited by preincubation of MC(–) lysate with increasing concentrations of microcystin. MS revealed that phycocyanin and the core-membrane linker peptide are the responsible allergens, and MC(–) extracts containing these proteins induced β-hexosaminidase release in rat basophil leukemia cells. Conclusions Phycobiliprotein complexes in M. aeruginosa have been identified as the relevant sensitizing proteins. Our finding that allergenicity is inhibited in a dose-dependent manner by microcystin toxin suggests that further investigation is warranted to understand the interplay between immunogenicity and toxicity of cyanobacteria under diverse environmental conditions. Citation Geh EN, Ghosh D, McKell M, de la Cruz AA, Stelma G, Bernstein JA. 2015. Identification of Microcystis aeruginosa peptides responsible for allergic sensitization and characterization of functional interactions between cyanobacterial toxins and immunogenic peptides. Environ Health Perspect 123:1159–1166; http://dx.doi.org/10.1289/ehp.1409065 PMID:25902363

Timing of Maternal Immunization Affects Immunological and Behavioral Outcomes of Adult Offspring in Siberian Hamsters (Phodopus sungorus)

PubMed Central

French, Susannah S.; Chester, Emily M.; Demas, Gregory E.

2016-01-01

Maternal influences are an important contributing factor to offspring survival, development, and behavior. Common environmental pathogens can induce maternal immune responses and affect subsequent development of offspring. There are likely sensitive periods during pregnancy when animals are particularly vulnerable to environmental disruption. Here we characterize the effects of maternal immunization across pregnancy and postpartum on offspring physiology and behavior in Siberian hamsters (Phodopus sungorus). Hamsters were injected with the antigen keyhole limpet hemocyanin (KLH) 1) prior to pairing with a male (pre-mating), 2) at separation (post-mating), 3) at mid-pregnancy, or 4) after birth (lactation). Maternal food intake, body mass, and immunity were monitored throughout gestation, and litters were measured weekly for growth until adulthood when social behavior, hormone concentrations, and immune responses were determined. We found that immunizations altered maternal immunity throughout pregnancy and lactation. The effects of maternal treatment differed between male and female offspring. Aggressive behavior was enhanced in offspring of both sexes born to mothers treated post-mating and thus early in pregnancy relative to other stages. In contrast, maternal treatment and maternal stage differentially affected innate immunity in males and females. Offspring cortisol, however, was unaffected by maternal treatment. Collectively, these data demonstrate that maternal immunization affects offspring physiology and behavior in a time-dependent and sex-specific manner. More broadly, these findings contribute to our understanding of the effects of maternal immune activation, whether it be from environmental exposure or immunization, on immunological and behavioral responses of offspring. PMID:27320639

Exceptional points enhance sensing in an optical microcavity

NASA Astrophysics Data System (ADS)

Chen, Weijian; Kaya Özdemir, Şahin; Zhao, Guangming; Wiersig, Jan; Yang, Lan

2017-08-01

Sensors play an important part in many aspects of daily life such as infrared sensors in home security systems, particle sensors for environmental monitoring and motion sensors in mobile phones. High-quality optical microcavities are prime candidates for sensing applications because of their ability to enhance light-matter interactions in a very confined volume. Examples of such devices include mechanical transducers, magnetometers, single-particle absorption spectrometers, and microcavity sensors for sizing single particles and detecting nanometre-scale objects such as single nanoparticles and atomic ions. Traditionally, a very small perturbation near an optical microcavity introduces either a change in the linewidth or a frequency shift or splitting of a resonance that is proportional to the strength of the perturbation. Here we demonstrate an alternative sensing scheme, by which the sensitivity of microcavities can be enhanced when operated at non-Hermitian spectral degeneracies known as exceptional points. In our experiments, we use two nanoscale scatterers to tune a whispering-gallery-mode micro-toroid cavity, in which light propagates along a concave surface by continuous total internal reflection, in a precise and controlled manner to exceptional points. A target nanoscale object that subsequently enters the evanescent field of the cavity perturbs the system from its exceptional point, leading to frequency splitting. Owing to the complex-square-root topology near an exceptional point, this frequency splitting scales as the square root of the perturbation strength and is therefore larger (for sufficiently small perturbations) than the splitting observed in traditional non-exceptional-point sensing schemes. Our demonstration of exceptional-point-enhanced sensitivity paves the way for sensors with unprecedented sensitivity.

Clinical Usefulness of the Histoculture Drug Response Assay for Prostate Cancer and Benign Prostate Hypertrophy (BPH).

PubMed

Hoffman, Robert M

2018-01-01

The histoculture drug response assay (HDRA) has been adapted to determine androgen sensitivity in Gelfoam histoculture of human benign prostatic tissue as well as prostate cancer. Gelfoam histoculture was used to measure androgen-independent and androgen-dependent growth of benign and malignant prostate tissue. The androgen-sensitivity index was significantly higher in 23 paired specimens of prostate cancer compared to benign prostate hypertrophy (BPH). Genistein decreased the androgen-sensitivity index of BPH and prostate cancer in Gelfoam ® histoculture in a dose-dependent manner.

Nonmutagenicity of betel leaf and its antimutagenic action against environmental mutagens.

PubMed

Nagabhushan, M; Amonkar, A J; D'Souza, A V; Bhide, S V

1987-01-01

Betel leaf (Piper betel) water and acetone extract are nonmutagenic in S. typhimurium strains with and without S9 mix. Both the extracts suppress the mutagenicity of betel quid mutagens in a dose dependent manner. Moreover both the extracts of betel leaf reduce the mutagenicity of benzo(a)pyrene and dimethylbenzanthracene. Acetone extract is more potent than water extract in inhibiting mutagenicity of environmental mutagens.

Neurobehavioral foundation of environmental reactivity.

PubMed

Moore, Sarah R; Depue, Richard A

2016-02-01

Sensitivity to environmental context has been of interest for many years, but the nature of individual differences in environmental sensitivity has become of particular focus over the past 2 decades. What is particularly uncertain are the neural variables and processes that mediate the effects of environment on developmental outcomes. Accordingly, we provide a neurobehavioral foundation of reactivity to the environment in several steps. First, the different patterns of environmental sensitivity are defined to identify the significant factors involved in the manifestation of these patterns. Second, we focus on neurobiological reactivity as the construct underlying variation in sensitivity to the environment by (a) providing an organizing threshold model of elicitation of neurobiology by environmental context; and (b) integrating the literature on 2 sets of neuromodulators in terms of each modulator's (a) contribution to neural and behavioral reactivity to stimulation, and (b) relation to emotional-motivational systems (dopamine, opiates and oxytocin, corticotropin-releasing hormone) or the general modulation of those systems (serotonin, norepinephrine, and GABA). Discussion concludes with (a) a comprehensive neurobehavioral framework of environmental reactivity based on a combinatorial model of a supertrait, (b) methodological implications of the model, and (c) a developmental perspective on environmental reactivity. (c) 2016 APA, all rights reserved).

The Effect of Nature Documentaries on Students' Environmental Sensitivity: A Case Study

ERIC Educational Resources Information Center

Barbas, Tasos A.; Paraskevopoulos, Stefanos; Stamou, Anastasia G.

2009-01-01

Despite the potential educational value of nature documentaries, the contribution of such films to environmental education is largely unknown. In the present study, we attempt to delineate the role of nature documentaries to the environmental sensitivity of students when the films are simply introduced to the class. More specifically, the present…

Application of environmental sensitivity theories in personalized prevention for youth substance abuse: a transdisciplinary translational perspective.

PubMed

Thibodeau, Eric L; August, Gerald J; Cicchetti, Dante; Symons, Frank J

2016-03-01

Preventive interventions that target high-risk youth, via one-size-fits-all approaches, have demonstrated modest effects in reducing rates of substance use. Recently, substance use researchers have recommended personalized intervention strategies. Central to these approaches is matching preventatives to characteristics of an individual that have been shown to predict outcomes. One compelling body of literature on person × environment interactions is that of environmental sensitivity theories, including differential susceptibility theory and vantage sensitivity. Recent experimental evidence has demonstrated that environmental sensitivity (ES) factors moderate substance abuse outcomes. We propose that ES factors may augment current personalization strategies such as matching based on risk factors/severity of problem behaviors (risk severity (RS)). Specifically, individuals most sensitive to environmental influence may be those most responsive to intervention in general and thus need only a brief-type or lower-intensity program to show gains, while those least sensitive may require more comprehensive or intensive programming for optimal responsiveness. We provide an example from ongoing research to illustrate how ES factors can be incorporated into prevention trials aimed at high-risk adolescents.

Environmental management zoning for coal mining in mainland China based on ecological and resources conditions.

PubMed

Geng, Haiqing; Chen, Fan; Wang, Zhiyuan; Liu, Jie; Xu, Weihua

2017-05-01

The purpose of this research is to establish an environmental management zoning for coal mining industry which is served as a basis for making environmental management policies. Based on the specific impacts of coal mining and regional characteristics of environment and resources, the ecological impact, water resources impact, and arable land impact are chose as the zoning indexes to construct the index system. The ecological sensitivity is graded into three levels of low, medium, and high according to analytical hierarchy processes and gray fixed weight clustering analysis, and the water resources sensitivity is divided into five levels of lower, low, medium, high, and higher according to the weighted sum of sub-indexes, while only the arable land sensitive zone was extracted on the basis of the ratio of arable land to the county or city. By combining the ecological sensitivity zoning and the water resources sensitive zoning and then overlapping the arable-sensitive areas, the mainland China is classified into six types of environmental management zones for coal mining except to the forbidden exploitation areas.

30 CFR 280.2 - What is the purpose of this part?

Code of Federal Regulations, 2010 CFR

2010-07-01

... prospecting activities or scientific research activities on the OCS in Federal waters related to hard minerals... activities or scientific research activities in a safe and environmentally sound manner so as to prevent harm...

30 CFR 251.2 - Purpose of this part.

Code of Federal Regulations, 2010 CFR

2010-07-01

... environmentally sound manner so as to prevent harm or damage to, or waste of, any natural resources (including any..., or the marine, coastal, or human environment. (c) To inform you and third parties of your legal and...

30 CFR 251.2 - Purpose of this part.

Code of Federal Regulations, 2011 CFR

2011-07-01

... activities in a safe and environmentally sound manner so as to prevent harm or damage to, or waste of, any... and other aquatic life), property, or the marine, coastal, or human environment. (c) To inform you and...

Energy Technology.

ERIC Educational Resources Information Center

Eaton, William W.

Reviewed are technological problems faced in energy production including locating, recovering, developing, storing, and distributing energy in clean, convenient, economical, and environmentally satisfactory manners. The energy resources of coal, oil, natural gas, hydroelectric power, nuclear energy, solar energy, geothermal energy, winds, tides,…

43 CFR 3252.11 - What environmental requirements must I meet when conducting exploration operations?

Code of Federal Regulations, 2011 CFR

2011-10-01

... operations in a manner that: (1) Protects the quality of surface and subsurface waters, air, and other natural resources, including wildlife, soil, vegetation, and natural history; (2) Protects the quality of...

BDNF rs6265 methylation and genotype interact on risk for schizophrenia.

PubMed

Ursini, Gianluca; Cavalleri, Tommaso; Fazio, Leonardo; Angrisano, Tiziana; Iacovelli, Luisa; Porcelli, Annamaria; Maddalena, Giancarlo; Punzi, Giovanna; Mancini, Marina; Gelao, Barbara; Romano, Raffaella; Masellis, Rita; Calabrese, Francesca; Rampino, Antonio; Taurisano, Paolo; Di Giorgio, Annabella; Keller, Simona; Tarantini, Letizia; Sinibaldi, Lorenzo; Quarto, Tiziana; Popolizio, Teresa; Caforio, Grazia; Blasi, Giuseppe; Riva, Marco A; De Blasi, Antonio; Chiariotti, Lorenzo; Bollati, Valentina; Bertolino, Alessandro

2016-01-01

Epigenetic mechanisms can mediate gene-environment interactions relevant for complex disorders. The BDNF gene is crucial for development and brain plasticity, is sensitive to environmental stressors, such as hypoxia, and harbors the functional SNP rs6265 (Val(66)Met), which creates or abolishes a CpG dinucleotide for DNA methylation. We found that methylation at the BDNF rs6265 Val allele in peripheral blood of healthy subjects is associated with hypoxia-related early life events (hOCs) and intermediate phenotypes for schizophrenia in a distinctive manner, depending on rs6265 genotype: in ValVal individuals increased methylation is associated with exposure to hOCs and impaired working memory (WM) accuracy, while the opposite is true for ValMet subjects. Also, rs6265 methylation and hOCs interact in modulating WM-related prefrontal activity, another intermediate phenotype for schizophrenia, with an analogous opposite direction in the 2 genotypes. Consistently, rs6265 methylation has a different association with schizophrenia risk in ValVals and ValMets. The relationships of methylation with BDNF levels and of genotype with BHLHB2 binding likely contribute to these opposite effects of methylation. We conclude that BDNF rs6265 methylation interacts with genotype to bridge early environmental exposures to adult phenotypes, relevant for schizophrenia. The study of epigenetic changes in regions containing genetic variation relevant for human diseases may have beneficial implications for the understanding of how genes are actually translated into phenotypes.

Toxicity of triphenyltin and tributyltin to the freshwater mudsnail Potamopyrgus antipodarum in a new sediment biotest.

PubMed

Duft, Martina; Schulte-Oehlmann, Ulrike; Tillmann, Michaela; Markert, Bernd; Oehlmann, Jörg

2003-01-01

The effects of two suspected endocrine-disrupting chemicals, the xeno-androgens triphenyltin (TPT) and tributyltin (TBT), were investigated in a new whole-sediment biotest with the freshwater mudsnail Potamopyrgus antipodarum (Gastropoda, Prosobranchia). Artificial sediments were spiked with seven concentrations, ranging from 10 to 500 microg nominal TPT-Sn/kg dry weight and TBT-Sn/kg dry weight, respectively. We analyzed the responses of the test species after two, four, and eight weeks exposure. For both compounds, P. antipodarum exhibited a sharp decline in the number of embryos sheltered in its brood pouch in a time- and concentration-dependent manner in comparison to the control sediment. The number of new, still unshelled embryos turned out to be the most sensitive parameter. The lowest-observed-effect concentration (LOEC) was equivalent to the lowest administered concentration (10 microg/kg of each test compound) for most parameters and thus no no-observed-effect concentration (NOEC) could be established. The calculation of effect concentrations (EC10) resulted in even lower values for both substances (EC10 after eight weeks for unshelled embryos: 0.03 microg TPT-Sn/kg, EC10 after four weeks for unshelled embryos: 0.98 microg TBT-Sn/kg). Our results indicate that P. antipodarum is highly sensitive to both endocrine disruptors TPT and TBT at environmentally relevant concentrations.

Diagnosing environmental allergies: Comparison of skin-prick, intradermal, and serum specific immunoglobulin E testing

PubMed Central

Shtessel, Maria; Lobell, Elizabeth; Hudes, Golda; Rosenstreich, David; de Vos, Gabriele

2017-01-01

Background: Allergists commonly perform intradermal skin testing (IDST) after negative skin-prick testing (SPT) to comprehensively diagnose environmental allergic sensitization. However, with the availability of modern methods to detect serum-specific immunoglobulin E (ssIgE), it is unclear if ssIgE testing could substitute for IDST. Objective: To determine the efficacy of ssIgE testing and IDST when added to SPT in diagnosing environmental allergic sensitizations. Methods: SPT, IDST, and ssIgE testing to nine common environmental allergens were analyzed in 75 patients with oculonasal symptoms who presented to our allergy clinics in the Bronx, New York, between January 2014 and May 2015. Results: A total of 651 SPT and 499 ssIgE tests were independently performed and revealed 162 (25%) and 127 (25%) sensitizations, respectively. When SPT results were negative, IDST results revealed 108 of 452 additional sensitizations (24%). In contrast, when SPT results were negative, ssIgE test results only revealed 9% additional sensitizations. When both SPT and IDST results were negative, ssIgE testing only detected 3% of additional sensitizations, and ssIgE levels were typically low in these cases (median, 1.25 kU/L; range, 0.357–4.47 kU/L). When both SPT and ssIgE test results were negative, IDST results detected 15% additional sensitizations. Conclusion: IDST detected more additional environmental sensitizations compared with ssIgE testing. IDST, therefore, may be useful when the SPT and/or ssIgE testing results were negative, but the exposure history indicated relevant allergic sensitization. Serology added only a little more information if both SPT and IDST results were negative but may be useful in combination with SPT if IDST cannot be performed. PMID:28583228

Diagnosing environmental allergies: Comparison of skin-prick, intradermal, and serum specific immunoglobulin E testing.

PubMed

Ferastraoaru, Denisa; Shtessel, Maria; Lobell, Elizabeth; Hudes, Golda; Rosenstreich, David; de Vos, Gabriele

2017-06-01

Allergists commonly perform intradermal skin testing (IDST) after negative skin-prick testing (SPT) to comprehensively diagnose environmental allergic sensitization. However, with the availability of modern methods to detect serum-specific immunoglobulin E (ssIgE), it is unclear if ssIgE testing could substitute for IDST. To determine the efficacy of ssIgE testing and IDST when added to SPT in diagnosing environmental allergic sensitizations. SPT, IDST, and ssIgE testing to nine common environmental allergens were analyzed in 75 patients with oculonasal symptoms who presented to our allergy clinics in the Bronx, New York, between January 2014 and May 2015. A total of 651 SPT and 499 ssIgE tests were independently performed and revealed 162 (25%) and 127 (25%) sensitizations, respectively. When SPT results were negative, IDST results revealed 108 of 452 additional sensitizations (24%). In contrast, when SPT results were negative, ssIgE test results only revealed 9% additional sensitizations. When both SPT and IDST results were negative, ssIgE testing only detected 3% of additional sensitizations, and ssIgE levels were typically low in these cases (median, 1.25 kU/L; range, 0.357-4.47 kU/L). When both SPT and ssIgE test results were negative, IDST results detected 15% additional sensitizations. IDST detected more additional environmental sensitizations compared with ssIgE testing. IDST, therefore, may be useful when the SPT and/or ssIgE testing results were negative, but the exposure history indicated relevant allergic sensitization. Serology added only a little more information if both SPT and IDST results were negative but may be useful in combination with SPT if IDST cannot be performed.

Coal resources in environmentally-sensitive lands under federal management

USGS Publications Warehouse

Watson, William D.; Tully, John K.; Moser, Edward N.; Dee, David P.; Bryant, Karen; Schall, Richard; Allan, Harold A.

1995-01-01

This report presents estimates of coal-bearing acreage and coal tonnage in environmentally-sensitive areas. The analysis was conducted to provide data for rulemaking by the Federal Office of Surface Mining (Watson and others, 1995). The rulemaking clarifies conditions under which coal can be mined in environmentally-sensitive areas. The area of the U.S. is about 2.3 billion acres. Contained within that acreage are certain environmentally-sensitive and unique areas (including parks, forests, and various other Federal land preserves). These areas are afforded special protection under Federal and State law. Altogether these protected areas occupy about 400 million acres. This report assesses coal acreage and coal tonnage in these protected Federal land preserves. Results are presented in the form of 8 map-displays prepared using GIS methods at a national scale. Tables and charts that accompany each map provide estimates of the total acreage in Federal land preserve units that overlap or fall within coal fields, coal-bearing acreage in each unit, and coal tonnage in each unit. Summary charts, compiled from the maps, indicate that about 8% of the Nation's coal reserves are located within environmentally-sensitive Federal land preserves.

Coastal resource and sensitivity mapping of Vietnam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Odin, L.M.

1997-08-01

This paper describes a project to establish a relationship between environmental sensitivity (primarily to oil pollution) and response planning and prevention priorities for Vietnamese coastal regions. An inventory of coastal environmental sensitivity and the creation of index mapping was performed. Satellite and geographical information system data were integrated and used for database creation. The database was used to create a coastal resource map, coastal sensitivity map, and a field inventory base map. The final coastal environment sensitivity classification showed that almost 40 percent of the 7448 km of mapped shoreline has a high to medium high sensitivity to oil pollution.

Air and Water Quality Impacts of Brownfields Redevelopment: A Study of Five Communities

EPA Pesticide Factsheets

This Study of Five Communities tests an analytical approach to quantifying the environmental impacts of multiple redevelopment projects in a given municipal area in a manner that can be replicated in other regions.

40 CFR 61.162 - Emission limits.

Code of Federal Regulations, 2014 CFR

2014-07-01

... maintain the furnace and associated air pollution control equipment in a manner consistent with good air... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions...

40 CFR 61.162 - Emission limits.

Code of Federal Regulations, 2011 CFR

2011-07-01

... maintain the furnace and associated air pollution control equipment in a manner consistent with good air... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions...

40 CFR 61.162 - Emission limits.

Code of Federal Regulations, 2013 CFR

2013-07-01

... maintain the furnace and associated air pollution control equipment in a manner consistent with good air... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions...

40 CFR 61.162 - Emission limits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... maintain the furnace and associated air pollution control equipment in a manner consistent with good air... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions...

40 CFR 61.162 - Emission limits.

Code of Federal Regulations, 2012 CFR

2012-07-01

... maintain the furnace and associated air pollution control equipment in a manner consistent with good air... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions...

40 CFR 721.6090 - Phosphoramide.

Code of Federal Regulations, 2010 CFR

2010-07-01

....6090 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT...) Hazard communication program. A significant new use of this substance is any manner or method of manufacture, import, or processing associated with any use of this substance without providing risk...

An International Study of the Propensity of Students to Limit Their Use of Private Transport in Light of Their Understanding of the Causes of Global Warming

ERIC Educational Resources Information Center

Boyes, Eddie; Stanisstreet, Martin; Skamp, Keith; Rodriguez, Manuel; Malandrakis, Georgios; Fortner, Rosanne W.; Kilinc, Ahmet; Taylor, Neil; Chhokar, Kiran; Dua, Shweta; Ambusaidi, Abdullah; Cheong, Irene Poh-Ai; Kim, Mijung; Yoon, Hye-Gyoung

2014-01-01

Previous studies have shown that there is what has been called a "gap" between environmental knowledge and a willingness to act in a pro-environmental manner. For the individual, this gap is probably the result of the huge complexity of factors that affect behaviour. The way in which this "gap" is sometimes identified in the…

Environmentally sensitive maintenance for dirt and gravel roads

DOT National Transportation Integrated Search

2007-10-01

This is a nonpoint source pollution project that identifies, documents, and encourages the use of environmentally sensitive maintenance of dirt and gravel roads. Specifically, this project involved the development of a reference manual and related te...

Inequality across consonantal contrasts in speech perception: evidence from mismatch negativity.

PubMed

Cornell, Sonia A; Lahiri, Aditi; Eulitz, Carsten

2013-06-01

The precise structure of speech sound representations is still a matter of debate. In the present neurobiological study, we compared predictions about differential sensitivity to speech contrasts between models that assume full specification of all phonological information in the mental lexicon with those assuming sparse representations (only contrastive or otherwise not predictable information is stored). In a passive oddball paradigm, we studied the contrast sensitivity as reflected in the mismatch negativity (MMN) response to changes in the manner of articulation, as well as place of articulation of consonants in intervocalic positions of nonwords (manner of articulation: [edi ~ eni], [ezi ~ eni]; place of articulation: [edi ~ egi]). Models that assume full specification of all phonological information in the mental lexicon posit equal MMNs within each contrast (symmetric MMNs), that is, changes from standard [edi] to deviant [eni] elicit a similar MMN response as changes from standard [eni] to deviant [edi]. In contrast, models that assume sparse representations predict that only the [ezi] ~ [eni] reversals will evoke symmetric MMNs because of their conflicting fully specified manner features. Asymmetric MMNs are predicted, however, for the reversals of [edi] ~ [eni] and [edi] ~ [egi] because either a manner or place property in each pair is not fully specified in the mental lexicon. Our results show a pattern of symmetric and asymmetric MMNs that is in line with predictions of the featurally underspecified lexicon model that assumes sparse phonological representations. We conclude that the brain refers to underspecified phonological representations during speech perception. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

Spectral Sensitivity Change May Precede Habitat Shift in the Developing Retina of the Atlantic Tarpon (Megalops atlanticus).

PubMed

Schweikert, Lorian E; Grace, Michael S

Fish that undergo ontogenetic migrations between habitats often encounter new light environments that require changes in the spectral sensitivity of the retina. For many fish, sensitivity of the retina changes to match the environmental spectrum, but the timing of retinal change relative to habitat shift remains unknown. Does retinal change in fish precede habitat shift, or is it a response to encountered changes in environmental light? Spectral sensitivity changes were examined over the development of the Atlantic tarpon (Megalops atlanticus) retina relative to ontogenetic shifts in habitat light. Opsin gene isoform expression and inferred chromophore use of visual pigments were examined over the course of M. atlanticus development. Spectral sensitivity of the retina was then determined by electroretinography and compared to the spectroradiometric measurements of habitat light encountered by M. atlanticus from juveniles to adults. These data, along with previously known microspectrophotometric measurements of sensitivity in M. atlanticus, indicate retinal spectral sensitivity that matches the dominant wavelengths of environmental light for juvenile and adult fish. For the intervening subadult stage, however, spectral sensitivity does not match the dominant wavelength of light it occupies but better matches the dominant wavelengths of light in the habitat of its forthcoming migration. These results first indicate that the relationship between environmental light spectrum and spectral sensitivity of the retina changes during M. atlanticus development and then suggest that such changes may be programmed to support visual anticipation of new photic environments.

40 CFR 721.9540 - Polysulfide mixture.

Code of Federal Regulations, 2010 CFR

2010-07-01

... new information, and any information on methods for protecting against such risk, into the applicable... 721.9540 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... substance is any manner or method of manufacture, import, or processing associated with any use of this...

Environmentally Sensitive Area (ESA) Grant Condition Waiver Program in Region 2

EPA Pesticide Factsheets

Starting in October 1979, EPA Region 2 applied a special condition to many wastewater facilities’ construction grants (see Federal Register, Vol. 43, No. 188, September 27, 1978) to protect Environmentally Sensitive Areas(EASs) from induced development.

Real-Time, Single-Step Bioassay Using Nanoplasmonic Resonator With Ultra-High Sensitivity

NASA Technical Reports Server (NTRS)

Zhang, Xiang (Inventor); Chen, Fanqing Frank (Inventor); Su, Kai-Hang (Inventor); Wei, Qi-Huo (Inventor); Ellman, Jonathan A. (Inventor); Sun, Cheng (Inventor)

2014-01-01

A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes.

Real-time, single-step bioassay using nanoplasmonic resonator with ultra-high sensitivity

DOEpatents

Zhang, Xiang; Ellman, Jonathan A; Chen, Fanqing Frank; Su, Kai-Hang; Wei, Qi-Huo; Sun, Cheng

2014-04-01

A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes.

IL-33 promotes gastrointestinal allergy in a TSLP-independent manner

PubMed Central

Han, Hongwei; Roan, Florence; Johnston, Laura K.; Smith, Dirk E.; Bryce, Paul J.; Ziegler, Steven F.

2017-01-01

Atopic dermatitis (AD) often precedes asthma and food allergy, indicating that epicutaneous sensitization to allergens may be important in the induction of allergic responses at other barrier surfaces. Thymic stromal lymphopoietin (TSLP) and IL-33 are two cytokines that may drive type 2 responses in the skin; both are potential targets in the treatment of allergic diseases. We tested the functional role of IL-33 and the interplay between IL-33 and TSLP in mouse models of atopic march and gastrointestinal allergy. IL-33-driven allergic disease occurred in a TSLP-independent manner. In contrast, mice lacking IL-33 signaling were protected from onset of allergic diarrhea in TSLP-driven disease. Epithelial-derived IL-33 was important in this model, since specific loss of IL-33 expression in the epithelium attenuated cutaneous inflammation. Notably, the development of diarrhea following sensitization with TLSP plus antigen was ameliorated even when IL-33 was blocked after sensitization. Thus, IL-33 plays an important role during early cutaneous inflammation and during challenge. These data reveal critical roles for IL-33 in the “atopic march” that leads from atopic dermatitis to gastrointestinal allergy. PMID:28656964

A Wireless Fully Passive Neural Recording Device for Unobtrusive Neuropotential Monitoring.

PubMed

Kiourti, Asimina; Lee, Cedric W L; Chae, Junseok; Volakis, John L

2016-01-01

We propose a novel wireless fully passive neural recording device for unobtrusive neuropotential monitoring. Previous work demonstrated the feasibility of monitoring emulated brain signals in a wireless fully passive manner. In this paper, we propose a novel realistic recorder that is significantly smaller and much more sensitive. The proposed recorder utilizes a highly efficient microwave backscattering method and operates without any formal power supply or regulating elements. Also, no intracranial wires or cables are required. In-vitro testing is performed inside a four-layer head phantom (skin, bone, gray matter, and white matter). Compared to our former implementation, the neural recorder proposed in this study has the following improved features: 1) 59% smaller footprint, 2) up to 20-dB improvement in neuropotential detection sensitivity, and 3) encapsulation in biocompatible polymer. For the first time, temporal emulated neuropotentials as low as 63 μVpp can be detected in a wireless fully passive manner. Remarkably, the high-sensitivity achieved in this study implies reading of most neural signals generated by the human brain. The proposed recorder brings forward transformational possibilities in wireless fully passive neural detection for a very wide range of applications (e.g., epilepsy, Alzheimer's, mental disorders, etc.).

Making Sense of Palaeoclimate Sensitivity

NASA Technical Reports Server (NTRS)

Rohling, E. J.; Sluijs, A.; DeConto, R.; Drijfhout, S. S.; Fedorov, A.; Foster, G. L.; Ganopolski, A.; Hansen, J.; Honisch, B.; Hooghiemstra, H.;

Switchable and non-switchable zero backscattering of dielectric nano-resonators

DOE PAGES

Wang, Feng; Wei, Qi -Huo; Htoon, Han

2015-02-27

Previous studies have shown that two-dimensional (2D) arrays of high-permittivity dielectric nanoparticles are capable of fully suppressing backward light scattering when the resonant frequencies of electrical and magnetic dipolar modes are coincident. In this paper, we numerically demonstrate that the zero-backscattering of 2D Si nanocuboid arrays can be engineered to be switchable or non-switchable in response to a variation in the environmental refractive index. For each cuboid width/length, there exist certain cuboid heights and orthogonal periodicity ratio for which the electrical and magnetic resonances exhibit similar spectra widths and equivalent sensitivities to the environmental index changes, so that the zero-backscatteringmore » is non-switchable upon environmental change. For some other cuboid heights and certain anisotropic periodicity ratios, the electric and magnetic modes exhibit different sensitivities to environmental index changes, making the zero-backscattering sensitive to environmental changes. We also show that by using two different types of nano-resonators in the unit cell, Fano resonances can be introduced to greatly enhance the switching sensitivity of zero-backscattering.« less

M-X Environmental Technical Report. Environmental Characteristics of Alternative Designated Deployment Areas, Protected Species.

DTIC Science & Technology

1980-12-22

RARE PLANTS LEGEND NUMBER SPECIES I Agave utabensis var. ebossspina 74 D. asperella var. ziorns, 147 Mentzela. leswophyll. 3 Angelica scabrida 75 D...cliffs Agave utahensis var. *boriapina Arctomecon merriami I Arenari a a tenomeres Gill. ripleyi Species known from bajadas of limestone mountains, with...hunters. Illegal collection of rare species of cacti or Agave . 3824-1 :Rare plants may he affected In the sa"e manner as native vegetation. See ETR

Environmental, Transient, Three-Dimensional, Hydrothermal, Mass Transport Code - FLESCOT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Onishi, Yasuo; Bao, Jie; Glass, Kevin A.

The purpose of the project was to modify and apply the transient, three-dimensional FLESCOT code to be able to effectively simulate cesium behavior in Fukushima lakes/dam reservoirs, river mouths, and coastal areas. The ultimate objective of the FLESCOT simulation is to predict future changes of cesium accumulation in Fukushima area reservoirs and costal water. These evaluation results will assist ongoing and future environmental remediation activities and policies in a systematic and comprehensive manner.

Sensitizing events as trigger for discursive renewal and institutional change in Flanders’ environmental health approach, 1970s-1990s

PubMed Central

2013-01-01

Background Sensitizing events may trigger and stimulate discursive renewal. From a discursive institutional perspective, changing discourses are the driving force behind the institutional dynamics of policy domains. Theoretically informed by discursive institutionalism, this article assesses the impact of a series of four sensitizing events that triggered serious environmental health concerns in Flanders between the 1970s till the 1990s, and led onto the gradual institutionalization of a Flemish environmental health arrangement. Methods The Policy Arrangement Approach is used as the analytical framework to structure the empirical results of the historical analysis based on document analysis and in-depth interviews. Results Until the 1990s, environmental health was characterized as an ad hoc policy field in Flanders, where agenda setting was based on sensitizing events – also referred to as incident-driven. Each of these events contributed to a gradual rethinking of the epistemological discourses about environmental health risks and uncertainties. These new discourses were the driving forces behind institutional dynamics as they gradually resulted in an increased need for: 1) long-term, policy-oriented, interdisciplinary environmental health research; 2) policy coordination and integration between the environmental and public health policy fields; and 3) new forms of science-policy interactions based on mutual learning. These changes are desirable in order to detect environmental health problems as fast as possible, to react immediately and communicate appropriately. Conclusions The series of four events that triggered serious environmental health concerns in Flanders provided the opportunity to rethink and re-organize the current affairs concerning environmental health and gradually resulted into the institutionalization of a Flemish environmental health arrangement. PMID:23758822

Rapid bioassessment methods for assessing vegetation toxicity at the Savannah River Site - germination tests and root elongation trials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Specht, W.L.; Klaine, S.J.; Hook, D.D.

1996-01-01

Plants form the basis of all ecosystems including wetlands. Although they are the most abundant life form and are the primary producers for all other organisms, they have received the least attention when it comes to environmental matters. Higher plants have rarely been used in ecotoxicity testing and may not respond in the same manner as algae, which have been used more frequently. The introduction of hazardous waste materials into wetland areas has the potential to alter and damage the ecological processes in these ecosystems. Measuring the impact of these contaminants on higher plants is therefore important and needs furthermore » research. Higher plants are useful for detecting both herbicidal toxicity and heavy metal toxicity. For phytotoxicity tests to be practical they must be simple, inexpensive, yet sensitive to a variety of contaminants. A difference between seed germination and root elongation tests is that seed germination tests measure toxicity associated with soils directly, while root elongation tests consider the indirect effects of water-soluble constituents that may be present in site samples.« less

Tolerance of pentose utilising yeast to hydrogen peroxide-induced oxidative stress.

PubMed

Spencer, Jennifer; Phister, Trevor G; Smart, Katherine A; Greetham, Darren

2014-03-17

Bioethanol fermentations follow traditional beverage fermentations where the yeast is exposed to adverse conditions such as oxidative stress. Lignocellulosic bioethanol fermentations involve the conversion of pentose and hexose sugars into ethanol. Environmental stress conditions such as osmotic stress and ethanol stress may affect the fermentation performance; however, oxidative stress as a consequence of metabolic output can also occur. However, the effect of oxidative stress on yeast with pentose utilising capabilities has yet to be investigated. Assaying for the effect of hydrogen peroxide-induced oxidative stress on Candida, Pichia and Scheffersomyces spp. has demonstrated that these yeast tolerate hydrogen peroxide-induced oxidative stress in a manner consistent with that demonstrated by Saccharomyces cerevisiae. Pichia guillermondii appears to be more tolerant to hydrogen peroxide-induced oxidative stress when compared to Candida shehatae, Candida succiphila or Scheffersomyces stipitis. Sensitivity to hydrogen peroxide-induced oxidative stress increased in the presence of minimal media; however, addition of amino acids and nucleobases was observed to increase tolerance. In particular adenine increased tolerance and methionine reduced tolerance to hydrogen peroxide-induced oxidative stress.

Tolerance of pentose utilising yeast to hydrogen peroxide-induced oxidative stress

PubMed Central

2014-01-01

Background Bioethanol fermentations follow traditional beverage fermentations where the yeast is exposed to adverse conditions such as oxidative stress. Lignocellulosic bioethanol fermentations involve the conversion of pentose and hexose sugars into ethanol. Environmental stress conditions such as osmotic stress and ethanol stress may affect the fermentation performance; however, oxidative stress as a consequence of metabolic output can also occur. However, the effect of oxidative stress on yeast with pentose utilising capabilities has yet to be investigated. Results Assaying for the effect of hydrogen peroxide-induced oxidative stress on Candida, Pichia and Scheffersomyces spp. has demonstrated that these yeast tolerate hydrogen peroxide-induced oxidative stress in a manner consistent with that demonstrated by Saccharomyces cerevisiae. Pichia guillermondii appears to be more tolerant to hydrogen peroxide-induced oxidative stress when compared to Candida shehatae, Candida succiphila or Scheffersomyces stipitis. Conclusions Sensitivity to hydrogen peroxide-induced oxidative stress increased in the presence of minimal media; however, addition of amino acids and nucleobases was observed to increase tolerance. In particular adenine increased tolerance and methionine reduced tolerance to hydrogen peroxide-induced oxidative stress. PMID:24636079

Sensitivity Analysis of QSAR Models for Assessing Novel Military Compounds

DTIC Science & Technology

2009-01-01

ER D C TR -0 9 -3 Strategic Environmental Research and Development Program Sensitivity Analysis of QSAR Models for Assessing Novel...Environmental Research and Development Program ERDC TR-09-3 January 2009 Sensitivity Analysis of QSAR Models for Assessing Novel Military Compound...Jay L. Clausen Cold Regions Research and Engineering Laboratory U.S. Army Engineer Research and Development Center 72 Lyme Road Hanover, NH

Network reconfiguration and neuronal plasticity in rhythm-generating networks.

PubMed

Koch, Henner; Garcia, Alfredo J; Ramirez, Jan-Marino

2011-12-01

Neuronal networks are highly plastic and reconfigure in a state-dependent manner. The plasticity at the network level emerges through multiple intrinsic and synaptic membrane properties that imbue neurons and their interactions with numerous nonlinear properties. These properties are continuously regulated by neuromodulators and homeostatic mechanisms that are critical to maintain not only network stability and also adapt networks in a short- and long-term manner to changes in behavioral, developmental, metabolic, and environmental conditions. This review provides concrete examples from neuronal networks in invertebrates and vertebrates, and illustrates that the concepts and rules that govern neuronal networks and behaviors are universal.

Fostering Pre-service Teachers' Self-Determined Environmental Motivation Through Green Chemistry Experiments

NASA Astrophysics Data System (ADS)

Karpudewan, Mageswary; Ismail, Zurida; Roth, Wolff-Michael

2012-10-01

The global environmental crisis intensifies particularly in developing nations. Environmental educators have begun to understand that changing the environmental impact requires not only changes in pro-environmental knowledge and attitudes but also in associated, self-determined motivation. This study was designed to test the hypothesis that a green chemistry curriculum changes Malaysian pre-service teachers' environmental motivation. Two comparable groups of pre-service teachers participated in this study. The students in the experimental group ( N = 140) did green chemistry experiments whereas the control group ( N = 123) did equivalent experiments in a traditional manner. Posttest results indicate that there is significant difference between both the groups for intrinsic motivation, integration, identification, and introjections scales and no differences for external regulation and amotivation scales. The qualitative analysis of interview data suggests that the changes are predominantly due to the personal satisfaction that participants derived from engaging in pro-environmental behavior.

Hydrothermal carbonization of livestock mortality for the reduction of pathogens and microbially-derived DNA

USDA-ARS?s Scientific Manuscript database

Hydrothermal carbonization (HTC), utilizing high temperature and pressure, has the potential to treat agricultural waste and inactivate pathogens, antibiotic resistance genes (ARG), and contaminants of emerging concern (CEC) in an environmentally and economically friendly manner. Livestock mortality...

40 CFR 63.1544 - Standards for fugitive dust sources.

Code of Federal Regulations, 2014 CFR

2014-07-01

... associated air pollution control equipment and monitoring equipment, in a manner consistent with safety and good air pollution control practices for minimizing emissions. Determination of whether such operation.... 63.1544 Section 63.1544 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR...

40 CFR 63.1544 - Standards for fugitive dust sources.

Code of Federal Regulations, 2012 CFR

2012-07-01

... associated air pollution control equipment and monitoring equipment, in a manner consistent with safety and good air pollution control practices for minimizing emissions. Determination of whether such operation.... 63.1544 Section 63.1544 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR...

40 CFR 63.1544 - Standards for fugitive dust sources.

Code of Federal Regulations, 2013 CFR

2013-07-01

... associated air pollution control equipment and monitoring equipment, in a manner consistent with safety and good air pollution control practices for minimizing emissions. Determination of whether such operation....1544 Section 63.1544 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...

30 CFR 282.12 - Director's responsibilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... completion of an environmental assessment or other NEPA document prepared pursuant to the regulations... are conducted in a manner that protects the environment and promotes orderly development of OCS..., any natural resource (including OCS mineral deposits and oil, gas, and sulphur resources in areas...

Audio-Visual Communications, A Tool for the Professional

ERIC Educational Resources Information Center

Journal of Environmental Health, 1976

1976-01-01

The manner in which the Cuyahoga County, Ohio Department of Environmental Health utilizes audio-visual presentations for communication with business and industry, professional public health agencies and the general public is presented. Subjects including food sanitation, radiation protection and safety are described. (BT)

PROCESS DESIGN MANUAL: LAND APPLICATION OF SEWAGE SLUDGE AND DOMESTIC SEPTAGE

EPA Science Inventory

Land application of sewage sludge generated by domestic sewage treatment is performed in an environmentally safe and cost–effective manner in many communities. Land application involves taking advantage of the fertilizing and soil conditioning properties of sewage sludge by sp...

Emergy and Its Importance

EPA Science Inventory

Emergy is an important quantity needed for public policy analysis that is based on a complex methodology. The intent of this Environmental Research Brief is to define emergy and its importance in a manner that is accessible to everyone with at least a high school education. Emer...

U1A Complex

ScienceCinema

None

2018-01-16

Some of the most sophisticated experiments in the stockpile stewardship program are conducted in an environmentally safe manner, nearly 1000 feet below the ground at the site. The U1a complex a sprawling underground laboratory and tunnel complex is home to a number of unique capabilities.

40 CFR 62.14490 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND... living organisms and their products, including vaccines, cultures, etc., intended for use in diagnosing..., process equipment, or a process to operate in a normal or usual manner. Failures that are caused, in part...

40 CFR 62.14490 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND... living organisms and their products, including vaccines, cultures, etc., intended for use in diagnosing..., process equipment, or a process to operate in a normal or usual manner. Failures that are caused, in part...

40 CFR 62.14490 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND..., including vaccines, cultures, etc., intended for use in diagnosing, immunizing, or treating humans or..., process equipment, or a process to operate in a normal or usual manner. Failures that are caused, in part...

New trends in the analytical determination of emerging contaminants and their transformation products in environmental waters.

PubMed

Agüera, Ana; Martínez Bueno, María Jesús; Fernández-Alba, Amadeo R

2013-06-01

Since the so-called emerging contaminants were established as a new group of pollutants of environmental concern, a great effort has been devoted to the knowledge of their distribution, fate and effects in the environment. After more than 20 years of work, a significant improvement in knowledge about these contaminants has been achieved, but there is still a large gap of information on the growing number of new potential contaminants that are appearing and especially of their unpredictable transformation products. Although the environmental problem arising from emerging contaminants must be addressed from an interdisciplinary point of view, it is obvious that analytical chemistry plays an important role as the first step of the study, as it allows establishing the presence of chemicals in the environment, estimate their concentration levels, identify sources and determine their degradation pathways. These tasks involve serious difficulties requiring different analytical solutions adjusted to purpose. Thus, the complexity of the matrices requires highly selective analytical methods; the large number and variety of compounds potentially present in the samples demands the application of wide scope methods; the low concentrations at which these contaminants are present in the samples require a high detection sensitivity, and high demands on the confirmation and high structural information are needed for the characterisation of unknowns. New developments on analytical instrumentation have been applied to solve these difficulties. Furthermore and not less important has been the development of new specific software packages intended for data acquisition and, in particular, for post-run analysis. Thus, the use of sophisticated software tools has allowed successful screening analysis, determining several hundreds of analytes, and assisted in the structural elucidation of unknown compounds in a timely manner.

Arsenite and Cadmium Activate MAPK/ERK via Membrane Estrogen Receptors and G-Protein Coupled Estrogen Receptor Signaling in Human Lung Adenocarcinoma Cells.

PubMed

Huff, Mary O; Todd, Sarah L; Smith, Aaron L; Elpers, Julie T; Smith, Alexander P; Murphy, Robert D; Bleser-Shartzer, Allison S; Hoerter, Jacob E; Radde, Brandie N; Klinge, Carolyn M

2016-07-01

Epidemiological evidence indicates that cadmium and arsenic exposure increase lung cancer risk. Cadmium and arsenic are environmental contaminants that act as endocrine disruptors (EDs) by activating estrogen receptors (ERs) in breast and other cancer cell lines but their activity as EDs in lung cancer is untested. Here, we examined the effect of cadmium chloride (CdCl2) and sodium arsenite (NaAsO2) on the proliferation of human lung adenocarcinoma cell lines. Results demonstrated that both CdCl2 and NaAsO2 stimulated cell proliferation at environmentally relevant nM concentrations in a similar manner to 17β-estradiol (E2) in H1793, H2073, and H1944 cells but not in H1792 or H1299 cells. Further studies in H1793 cells showed that 100 nM CdCl2 and NaAsO2 rapidly stimulated mitogen-activated protein kinase (MAPK, extracellular-signal-regulated kinases) phosphorylation with a peak detected at 15 min. Inhibitor studies suggest that rapid MAPK phosphorylation by NaAsO2, CdCl2, and E2 involves ER, Src, epidermal growth factor receptor, and G-protein coupled ER (GPER) in a pertussis toxin-sensitive pathway. CdCl2 and E2 activation of MAPK may also involve ERβ. This study supports the involvement of membrane ER and GPER signaling in mediating cellular responses to environmentally relevant nM concentrations of CdCl2 and NaAsO2 in lung adenocarcinoma cells. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Maternal house dust mite exposure during pregnancy enhances severity of house dust mite-induced asthma in murine offspring.

PubMed

Richgels, Phoebe K; Yamani, Amnah; Chougnet, Claire A; Lewkowich, Ian P

2017-11-01

Atopic status of the mother and maternal exposure to environmental factors are associated with increased asthma risk. Moreover, animal models demonstrate that exposure to allergens in strongly sensitized mothers influences offspring asthma development, suggesting that in utero exposures can influence offspring asthma. However, it is unclear whether maternal exposure to common human allergens such as house dust mite (HDM), in the absence of additional adjuvants, influences offspring asthma development. We sought to determine whether maternal HDM exposure influences asthma development in offspring. Pregnant female mice were exposed to PBS or HDM during pregnancy. Using offspring of PBS- or HDM-exposed mothers, the magnitude of HDM or Aspergillus fumigatus (AF) extract-induced airway hyperresponsiveness (AHR), airway inflammation, immunoglobulin production, T H 2-associated cytokine synthesis, and pulmonary dendritic cell activity was assessed. Compared with offspring of PBS-exposed mothers, offspring of HDM-exposed mothers demonstrate increased AHR, airway inflammation, T H 2 cytokine production, and immunoglobulin levels and a modest decrease in the phagocytic capacity of pulmonary macrophage populations following HDM exposure. Increased sensitivity to AF-induced airway disease was not observed. Offspring of HDM-exposed B-cell-deficient mothers also demonstrated increased HDM-induced AHR, suggesting that transfer of maternal immunoglobulins is not required. Our data demonstrate that maternal exposure to HDM during pregnancy increases asthma sensitivity in offspring in an HDM-specific manner, suggesting that vertical transmission of maternal immune responses may be involved. These findings have important implications for regulation of asthma risk, and suggest that exposure to HDM in the developed world may have underappreciated influences on the overall prevalence of allergic asthma. Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Plasmonic Interrogation of Biomimetic Systems for Enhanced Toxicity Assays

NASA Astrophysics Data System (ADS)

Hinman, Samuel Stuart

In light of their escalating exposure to possible environmental toxicants, there are many biological systems that need to be evaluated in a resource and time efficient manner. Understanding how toxicants behave in relation to their physicochemical properties and within complex biological media is especially important toward developing a stronger scientific foundation of these systems so that adequate regulatory decisions may be made. While there are many emerging methods available for the detection and characterization of these chemicals, nanotechnology has presented itself as a promising alternative toward creating more efficient assays. In particular, metallic nanoparticles and thin films exhibit unique optical properties that allow for highly sensitive and multiplexed studies to be performed. These plasmonic materials often preclude the use of molecular tags and labels, enabling direct characterizations and enhancing the throughput of biomolecular studies. However, their lack of specificity toward certain targets and potential toxicity has thus far precluded their widespread use in toxicity testing. The cell membrane, a natural signal transducer, represents one of the fundamental structures for biological recognition and communication. These interfaces principally function as a selective barrier to exogenous materials, including ions, signaling molecules, growth factors, and toxins; therefore, understanding interactions at membrane interfaces is a vital step in elucidating how biological responses are effected. Supported lipid bilayers, which may easily be tailored in composition and complexity, are ideal interfaces for coupling to plasmonic assays since they may be supported in close proximity to metallic nanoparticles and thin films, where measurements are most sensitive. This research will focus on the coupling of plasmonic materials and biomimetic interfaces to increase the sensitivity, efficiency, and throughput of conventional toxicity assays. The fabrication of new plasmonic materials for membrane-based assays is presented, as well as method developments in membrane array formation and opportunities for hyphenation with complementary analytical techniques.

Does ecohydrological connectivity affect sensitivity to environmental change?

EPA Science Inventory

Our goal is to understand the influences of complex terrain on the sensitivity of carbon and water cycle processes to environmental drivers at different scales. Gravity-driven flowpaths of air and water transport material and energy across and through landscapes, creating connec...

The Greenhouse Effect and the Destruction of the Ozone Shield: Implications for Rhetoric and Criticism.

NASA Astrophysics Data System (ADS)

Stoller, Martin Reid

Rhetoric, in the Aristotelian sense of "the available means of persuasion," is a crucial, often determining component of the process of making public policy generally, and environmental policy specifically. Environmental crises which have been addressed by the governmental, industrial, and social policy -making establishments have tended to be treated in a manner similar to that in which social, political, economic, military, and other problems have been commonly treated, utilizing a traditional rhetoric, including long-proven persuasive language and arguments. Such problems as air pollution and water pollution have been, to some degree, successfully addressed in this manner. A new and fundamentally different cluster of environmental problems has recently been recognized by elements of the policy making establishment as a legitimate candidate for consideration and policy formation. These environmental problems differ from the more familiar type in a variety of ways, each of which, to a greater or lesser degree, make problematic for those activists concerned with these crises the production of an effective crisis-oriented rhetoric. This study addresses two such closely related phenomena, the Greenhouse Effect and ozone depletion, and identifies those characteristics which contribute to their rhetorical complexity. Using traditional techniques of rhetorical examination, primarily neo-Aristotelian analysis, this study demonstrates the inadequacy of current crisis-oriented rhetoric, and identifies the causes of this rhetorical ineffectiveness. The study concludes that the mediation of such crises as the Greenhouse Effect and ozone depletion cannot be significantly facilitated by traditional environmental-oriented rhetoric, and may in fact be hindered by the use of rhetoric associated with fundamentally different (i.e., easier to solve) environmental problems.

Pertussis toxin-sensitive G-protein mediates the alpha 2-adrenergic receptor inhibition of melatonin release in photoreceptive chick pineal cell cultures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pratt, B.L.; Takahashi, J.S.

The avian pineal gland is a photoreceptive organ that has been shown to contain postjunctional alpha 2-adrenoceptors that inhibit melatonin synthesis and/or release upon receptor activation. Physiological response and (32P)ADP ribosylation experiments were performed to investigate whether pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins) were involved in the transduction of the alpha 2-adrenergic signal. For physiological response studies, the effects of pertussis toxin on melatonin release in dissociated cell cultures exposed to norepinephrine were assessed. Pertussis toxin blocked alpha 2-adrenergic receptor-mediated inhibition in a dose-dependent manner. Pertussis toxin-induced blockade appeared to be noncompetitive. One and 10 ng/ml doses of pertussis toxinmore » partially blocked and a 100 ng/ml dose completely blocked norepinephrine-induced inhibition. Pertussis toxin-catalyzed (32P)ADP ribosylation of G-proteins in chick pineal cell membranes was assessed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and autoradiography. Membranes were prepared from cells that had been pretreated with 0, 1, 10, or 100 ng/ml pertussis toxin. In the absence of pertussis toxin pretreatment, two major proteins of 40K and 41K mol wt (Mr) were labeled by (32P)NAD. Pertussis toxin pretreatment of pineal cells abolished (32P) radiolabeling of the 40K Mr G-protein in a dose-dependent manner. The norepinephrine-induced inhibition of both cAMP efflux and melatonin release, as assessed by RIA of medium samples collected before membrane preparation, was also blocked in a dose-dependent manner by pertussis toxin. Collectively, these results suggest that a pertussis toxin-sensitive 40K Mr G-protein labeled by (32P)NAD may be functionally associated with alpha 2-adrenergic signal transduction in chick pineal cells.« less

Effects of K(+) channel openers on spontaneous action potentials in detrusor smooth muscle of the guinea-pig urinary bladder.

PubMed

Takagi, Hiroaki; Hashitani, Hikaru

2016-10-15

The modulation of spontaneous excitability in detrusor smooth muscle (DSM) upon the pharmacological activation of different populations of K(+) channels was investigated. Effects of distinct K(+) channel openers on spontaneous action potentials in DSM of the guinea-pig bladder were examined using intracellular microelectrode techniques. NS1619 (10μM), a large conductance Ca(2+)-activated K(+) (BK) channel opener, transiently increased action potential frequency and then prevented their generation without hyperpolarizing the membrane in a manner sensitive to iberiotoxin (IbTX, 100nM). A higher concentration of NS1619 (30μM) hyperpolarized the membrane and abolished action potential firing. NS309 (10μM) and SKA31 (100μM), small conductance Ca(2+)-activated K(+) (SK) channel openers, dramatically increased the duration of the after-hyperpolarization and then abolished action potential firing in an apamin (100nM)-sensitive manner. Flupirtine (10μM), a Kv7 channel opener, inhibited action potential firing without hyperpolarizing the membrane in a manner sensitive to XE991 (10μM), a Kv7 channel blocker. BRL37344 (10μM), a β3-adrenceptor agonist, or rolipram (10nM), a phosphodiesterase 4 inhibitor, also inhibited action potential firing. A higher concentration of rolipram (100nM) hyperpolarized the DSM and abolished the action potentials. IbTX (100nM) prevented the rolipram-induced blockade of action potentials but not the hyperpolarization. BK and Kv7 channels appear to predominantly contribute to the stabilization of DSM excitability. Spare SK channels could be pharmacologically activated to suppress DSM excitability. BK channels appear to be involved in the cyclic AMP-induced inhibition of action potentials but not the membrane hyperpolarization. Copyright © 2016 Elsevier B.V. All rights reserved.

Evaluation of pesticide toxicities with differing mechanisms using Caenorhabditis elegans.

PubMed

Ruan, Qin-Li; Ju, Jing-Juan; Li, Yun-Hui; Liu, Ran; Pu, Yue-Pu; Yin, Li-Hong; Wang, Da-Yong

2009-01-01

The aim of this study was to (1) determine whether model organism Caenorhabditis elegans was sensitive to pesticides at the maximum concentration limits regulated by national agency standards, and (2) examine the multi-biological toxicities occurring as a result of exposure to pesticides. Five pesticides, namely, chlorpyrifos, imibacloprid, buprofezin, cyhalothrin, and glyphosate, with four different mechanisms of action were selected for the investigation. In accordance with national agency requirements, 4 exposed groups were used for each tested pesticide with the concentration scales ranging from 1.0 x 10(-3) to 1 mg/L. L4 larvae were exposed for 24 and 72 h, respectively. Endpoints of locomotion, propagation, and development were selected for the assay as parameters of toxicity. After exposure for 24 h, both the body bend frequency and head thrash frequency of nematodes exposed to chlorpyrifos, imibacloprid, and cyhalothrin decreased in a concentration-dependent manner, and there were significant differences between exposed groups at maximum concentration level (MCL) compared to control. The generation time of nematodes exposed to buprofezin 24 h significantly increased in a concentration-dependent manner in the highest exposed group. When exposed for 72 h, the body bend frequency and head thrash frequency of nematodes exposed to cyhalothrin markedly decreased at MCL. The generation time and brood size of nematodes exposed to buprofezin were reduced in a concentration-dependent manner. The behavior of nematodes was sensitive to pesticides with neurotoxic properties, while pesticides affecting insect growth modified the reproductive system. The effects of pesticides on nematodes exposed for 24 h appeared more sensitive than with exposure for 72 h. Caenorhabditis elegans may thus be used for assessing the adverse effects of pesticide residues in aquatic environment.

Detection of allergen sources in the homes of sensitized children.

PubMed

Álvarez-Chávez, Clara R; Flores-Bernal, José L; Esquer-Peralta, Javier; Munguía-Vega, Nora E; Corella-Madueño, María A G; Rascón-Careaga, Antonio; Turcotte, David; Velázquez-Contreras, Luis E

2016-11-01

To identify the presence of environmental factors linked to the onset of allergies and asthma in the homes of children participating in an early detection program that were identified with sensitivity to common allergens in the region of Sonora, Mexico. A walkthrough assessment was carried out in the homes of sensitized children; the research tools were the questionnaire and environmental checklist proposed by the Lowell Healthy Homes Program of the University of Massachusetts-Lowell. The results showed the presence of environmental allergen sources, to which most of the children in the study are sensitized, as well as the environmental conditions and habits that determine the quality of the indoor air of the households, were both related to triggering allergies and asthma in this population. A statistically significant association was found between the visual observation of dust inside homes and the sensitivity of children to dust mites. Dust found inside the home was the most relevant environmental factor related to positive cases of IgE in children. Early detection of allergies in children in the study and the methodology used in this investigation provided a useful framework for the design of plans and intervention alternatives in these homes to prevent the development of allergies and asthma panorama. These plans should be designed with a multidisciplinary approach to impact social, environmental and economic benefits in the family, improving the living conditions of the study population and contributing to the sustainable development goals of the United Nations for 2030.

Natural variation in germination responses of Arabidopsis to seasonal cues and their associated physiological mechanisms

PubMed Central

Barua, Deepak; Butler, Colleen; Tisdale, Tracy E.; Donohue, Kathleen

2012-01-01

Background and Aims Despite the intense interest in phenological adaptation to environmental change, the fundamental character of natural variation in germination is almost entirely unknown. Specifically, it is not known whether different genotypes within a species are germination specialists to particular conditions, nor is it known what physiological mechanisms of germination regulation vary in natural populations and how they are associated with responses to particular environmental factors. Methods We used a set of recombinant inbred genotypes of Arabidopsis thaliana, in which linkage disequilibrium has been disrupted over seven generations, to test for genetic variation and covariation in germination responses to distinct environmental factors. We then examined physiological mechanisms associated with those responses, including seed-coat permeability and sensitivity to the phytohormones gibberellic acid (GA) and abscisic acid (ABA). Key Results Genetic variation for germination was environment-dependent, but no evidence for specialization of germination to different conditions was found. Hormonal sensitivities also exhibited significant genetic variation, but seed-coat properties did not. GA sensitivity was associated with germination responses to multiple environmental factors, but seed-coat permeability and ABA sensitivity were associated with specific germination responses, suggesting that an evolutionary change in GA sensitivity could affect germination in multiple environments, but that of ABA sensitivity may affect germination under more restricted conditions. Conclusions The physiological mechanisms of germination responses to specific environmental factors therefore can influence the ability to adapt to diverse seasonal environments encountered during colonization of new habitats or with future predicted climate change. PMID:22012958

Analysis of the sensitivity of in vitro bioassays for androgenic, progestagenic, glucocorticoid, thyroid and estrogenic activity: Suitability for drinking and environmental waters.

PubMed

Leusch, Frederic D L; Neale, Peta A; Hebert, Armelle; Scheurer, Marco; Schriks, Merijn C M

2017-02-01

The presence of endocrine disrupting chemicals in the aquatic environment poses a risk for ecosystem health. Consequently there is a need for sensitive tools, such as in vitro bioassays, to monitor endocrine activity in environmental waters. The aim of the current study was to assess whether current in vitro bioassays are suitable to detect endocrine activity in a range of water types. The reviewed assays included androgenic (n=11), progestagenic (n=6), glucocorticoid (n=5), thyroid (n=5) and estrogenic (n=8) activity in both agonist and antagonist mode. Existing in vitro bioassay data were re-evaluated to determine assay sensitivity, with the calculated method detection limit compared with measured hormonal activity in treated wastewater, surface water and drinking water to quantify whether the studied assays were sufficiently sensitive for environmental samples. With typical sample enrichment, current in vitro bioassays are sufficiently sensitive to detect androgenic activity in treated wastewater and surface water, with anti-androgenic activity able to be detected in most environmental waters. Similarly, with sufficient enrichment, the studied mammalian assays are able to detect estrogenic activity even in drinking water samples. Fewer studies have focused on progestagenic and glucocorticoid activity, but some of the reviewed bioassays are suitable for detecting activity in treated wastewater and surface water. Even less is known about (anti)thyroid activity, but the available data suggests that the more sensitive reviewed bioassays are still unlikely to detect this type of activity in environmental waters. The findings of this review can help provide guidance on in vitro bioassay selection and required sample enrichment for optimised detection of endocrine activity in environmental waters. Copyright © 2016 Elsevier Ltd. All rights reserved.

Science and Mathematics Teacher Candidates' Environmental Knowledge, Awareness, Behavior and Attitudes

ERIC Educational Resources Information Center

Yumusak, Ahmet; Sargin, Seyid Ahmet; Baltaci, Furkan; Kelani, Raphael R.

2016-01-01

The purpose of this study was to measure science and mathematics teacher candidates' environmental knowledge level, awareness, behavior and environmental attitudes. Four instruments comprising Environmental Sensitivity Scale, environmental Behavior Scale, Environmental Attitudes Scale and Environmental Knowledge Test were administered to a total…

In Search of Shared and Nonshared Environmental Factors in Security of Attachment: A Behavior-Genetic Study of the Association between Sensitivity and Attachment Security

ERIC Educational Resources Information Center

Fearon, R. M. Pasco; Van IJzendoorn, Marinus H.; Fonagy, Peter; Bakermans-Kranenburg, Marian J.; Schuengel, Carlo; Bokhorst, Caroline L.

2006-01-01

The current article presents results from a twin study of genetic and environmental components of maternal sensitivity and infant attachment and their association. The sample consisted of 136 twin pairs from 2 sites: Leiden, the Netherlands, and London, UK. Maternal sensitivity was assessed in the home at 9-10 months, and infant attachment…

49 CFR 194.101 - Operators required to submit plans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... not operate at a maximum operating pressure established under § 195.406 that corresponds to a stress... is not in proximity to navigable waters, public drinking water intakes, or environmentally sensitive... the discharge, any navigable waters, public drinking water intake, or environmentally sensitive areas...

49 CFR 194.101 - Operators required to submit plans.

Code of Federal Regulations, 2011 CFR

2011-10-01

... not operate at a maximum operating pressure established under § 195.406 that corresponds to a stress... is not in proximity to navigable waters, public drinking water intakes, or environmentally sensitive... the discharge, any navigable waters, public drinking water intake, or environmentally sensitive areas...

The Model Optimization, Uncertainty, and SEnsitivity analysis (MOUSE) toolbox: overview and application

USDA-ARS?s Scientific Manuscript database

For several decades, optimization and sensitivity/uncertainty analysis of environmental models has been the subject of extensive research. Although much progress has been made and sophisticated methods developed, the growing complexity of environmental models to represent real-world systems makes it...

36 CFR 9.84 - Application requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... environmentally sound manner utilizing the least impacting technology suitable for the purposes of the project... MINERALS MANAGEMENT Alaska Mineral Resource Assessment Program § 9.84 Application requirements. (a) By... Director an application pursuant to § 9.84(b) for proposed AMRAP projects and activities discussed and...

36 CFR 9.84 - Application requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... environmentally sound manner utilizing the least impacting technology suitable for the purposes of the project... MINERALS MANAGEMENT Alaska Mineral Resource Assessment Program § 9.84 Application requirements. (a) By... Director an application pursuant to § 9.84(b) for proposed AMRAP projects and activities discussed and...

36 CFR 9.84 - Application requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... environmentally sound manner utilizing the least impacting technology suitable for the purposes of the project... MINERALS MANAGEMENT Alaska Mineral Resource Assessment Program § 9.84 Application requirements. (a) By... Director an application pursuant to § 9.84(b) for proposed AMRAP projects and activities discussed and...

36 CFR 9.84 - Application requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... environmentally sound manner utilizing the least impacting technology suitable for the purposes of the project... MINERALS MANAGEMENT Alaska Mineral Resource Assessment Program § 9.84 Application requirements. (a) By... Director an application pursuant to § 9.84(b) for proposed AMRAP projects and activities discussed and...

36 CFR 9.84 - Application requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... environmentally sound manner utilizing the least impacting technology suitable for the purposes of the project... MINERALS MANAGEMENT Alaska Mineral Resource Assessment Program § 9.84 Application requirements. (a) By... Director an application pursuant to § 9.84(b) for proposed AMRAP projects and activities discussed and...

30 CFR 282.28 - Environmental protection measures.

Code of Federal Regulations, 2012 CFR

2012-07-01

...)(1) The lessee shall monitor activities in a manner that develops the data and information necessary... activities on the environment on and off the lease; develop and evaluate methods for mitigating adverse... with lease and other requirements for the protection of the environment. (2) Monitoring of...

30 CFR 282.28 - Environmental protection measures.

Code of Federal Regulations, 2013 CFR

2013-07-01

...)(1) The lessee shall monitor activities in a manner that develops the data and information necessary... activities on the environment on and off the lease; develop and evaluate methods for mitigating adverse... with lease and other requirements for the protection of the environment. (2) Monitoring of...

30 CFR 282.28 - Environmental protection measures.

Code of Federal Regulations, 2014 CFR

2014-07-01

...)(1) The lessee shall monitor activities in a manner that develops the data and information necessary... activities on the environment on and off the lease; develop and evaluate methods for mitigating adverse... with lease and other requirements for the protection of the environment. (2) Monitoring of...

MOBILITY AND DEGRADATION OF RESIDUES AT HAZARDOUS WASTE LAND TREATMENT SITES AT CLOSURE

EPA Science Inventory

Soil treatment systems that are designed and managed based on a knowledge of soil-waste interactions may represent a significant technology for simultaneous treatment and ultimate disposal of selected hazardous wastes in an environmentally acceptable manner. hese soil treatment s...

47 CFR 95.406 - (CB Rule 6) Are there any special restrictions on the location of my CB station?

Code of Federal Regulations, 2011 CFR

2011-10-01

... COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Citizens Band (CB) Radio... operated in such a manner as to raise environmental problems, under § 1.1307 of this chapter, you must...

47 CFR 95.406 - (CB Rule 6) Are there any special restrictions on the location of my CB station?

Code of Federal Regulations, 2010 CFR

2010-10-01

... COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Citizens Band (CB) Radio... operated in such a manner as to raise environmental problems, under § 1.1307 of this chapter, you must...

Seismological medals

USGS Publications Warehouse

Schmidt, P.

1987-01-01

Seismic events are environmental events, so it is not surprising that mankind, in coming to terms with earthquakes, has tried to express his feelings about them in an artistic manner too. By understanding the topical importance of medals in seismological affairs, we can appreciate the hertiage of the past. 

40 CFR 721.3085 - Brominated phthalate ester.

Code of Federal Regulations, 2010 CFR

2010-07-01

... information, and any information on methods for protecting against such risk, into a MSDS as described in... Section 721.3085 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... substance is any manner or method of manufacture, import, or processing associated with any use of these...

40 CFR 721.3880 - Polyalkylene glycol substituted acetate.

Code of Federal Regulations, 2010 CFR

2010-07-01

... acetate. 721.3880 Section 721.3880 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... communication program. A significant new use of this substance is any manner or method of manufacture, import, or processing associated with any use of this substance without providing risk notification as...

40 CFR 721.3629 - Triethanolamine salts of fatty acids.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... 721.3629 Section 721.3629 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC...) Hazard communication program. A significant new use of these substances is any manner or method of manufacture, import, or processing associated with any use of these substances without providing risk...

40 CFR 721.3815 - Furan, 2-(ethoxymethyl)- tetrahydro-.

Code of Federal Regulations, 2010 CFR

2010-07-01

... new information, and any information on methods for protecting against such risk, into a Material...-. 721.3815 Section 721.3815 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... substance is any manner or method of manufacture, import, or processing associated with any use of this...

40 CFR 721.4620 - Dialkylamino alkanoate metal salt.

Code of Federal Regulations, 2010 CFR

2010-07-01

... this new information, and any information on methods for protecting against such risk, into a Material....4620 Section 721.4620 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... significant new use of this substance is any manner or method of manufacture, import, or processing associated...

40 CFR 721.4600 - Recovered metal hydroxide.

Code of Federal Regulations, 2010 CFR

2010-07-01

... this new information, and any information on methods for protecting against such risk, into an MSDS as... Section 721.4600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... new use of this substance is any manner or method of manufacture, import, or processing associated...

40 CFR 721.6060 - Alkylaryl substituted phosphite.

Code of Federal Regulations, 2010 CFR

2010-07-01

... this new information, and any information on methods for protecting against such risk, into an MSDS as....6060 Section 721.6060 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... significant new use of this substance is any manner or method of manufacture, import, or processing associated...

40 CFR 170.103 - Exceptions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Exceptions. 170.103 Section 170.103 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS WORKER PROTECTION... squirt,” “frill and spray,” chemigation, soil-incorporation, or soil-injection; (f) In a manner not...

40 CFR 240.208-2 - Recommended procedures: Design.

Code of Federal Regulations, 2010 CFR

2010-07-01

....208-2 Section 240.208-2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR THE THERMAL PROCESSING OF SOLID WASTES Requirements and Recommended Procedures... allow for removal from the site of residue or other solids in a manner that protects the environment. ...

Total Water Management: A Research Project of the United States Environmental Protection Agency

EPA Science Inventory

Total Water Management (TWM) examines urban water systems in an interconnected manner. It encompasses reducing water demands, increasing water recycling and reuse, creating water supply assets from stormwater management, matching water quality to end-use needs, and achieving envi...

30 CFR 282.11 - Director's authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... manner; (2) Balance OCS mineral resource development with protection of the human, marine, and coastal... holder to obtain additional environmental data when deemed necessary to assure adequate protection of the human, marine, and coastal environments. (2) The Director is to be provided an opportunity to inspect...

Salt Stress Induced Variation in DNA Methylation Pattern and Its Influence on Gene Expression in Contrasting Rice Genotypes

PubMed Central

Karan, Ratna; DeLeon, Teresa; Biradar, Hanamareddy; Subudhi, Prasanta K.

2012-01-01

Background Salinity is a major environmental factor limiting productivity of crop plants including rice in which wide range of natural variability exists. Although recent evidences implicate epigenetic mechanisms for modulating the gene expression in plants under environmental stresses, epigenetic changes and their functional consequences under salinity stress in rice are underexplored. DNA methylation is one of the epigenetic mechanisms regulating gene expression in plant’s responses to environmental stresses. Better understanding of epigenetic regulation of plant growth and response to environmental stresses may create novel heritable variation for crop improvement. Methodology/Principal Findings Methylation sensitive amplification polymorphism (MSAP) technique was used to assess the effect of salt stress on extent and patterns of DNA methylation in four genotypes of rice differing in the degree of salinity tolerance. Overall, the amount of DNA methylation was more in shoot compared to root and the contribution of fully methylated loci was always more than hemi-methylated loci. Sequencing of ten randomly selected MSAP fragments indicated gene-body specific DNA methylation of retrotransposons, stress responsive genes, and chromatin modification genes, distributed on different rice chromosomes. Bisulphite sequencing and quantitative RT-PCR analysis of selected MSAP loci showed that cytosine methylation changes under salinity as well as gene expression varied with genotypes and tissue types irrespective of the level of salinity tolerance of rice genotypes. Conclusions/Significance The gene body methylation may have an important role in regulating gene expression in organ and genotype specific manner under salinity stress. Association between salt tolerance and methylation changes observed in some cases suggested that many methylation changes are not “directed”. The natural genetic variation for salt tolerance observed in rice germplasm may be independent of the extent and pattern of DNA methylation which may have been induced by abiotic stress followed by accumulation through the natural selection process. PMID:22761959

The nature of context-sensitive solutions, stakeholder involvement and critical issues in the urban context.

DOT National Transportation Integrated Search

2011-12-01

Over the last several decades many transportation and planning agencies have experienced conflicting demands emerging from the need to develop projects in an expeditious manner while at the same time involving stakeholders in the decision-making proc...

Bug Off

ERIC Educational Resources Information Center

Copps, Patrick T.

2007-01-01

Insects and rodents in education facilities can cause structural damage, and they carry diseases that threaten food safety and the health of students and employees. To effectively prevent infestations and manage pests in a safe and eco-sensitive manner, many schools turn to integrated pest management (IPM) programs that emphasize environmentally…

48 CFR 1352.237-72 - Security processing requirements-national security contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... National Security Contracts require contractor employees to gain access to national security information in.... (c) Security Procedures. Position sensitivity/risk assessments must be conducted on all functions... same manner as assessment of those functions performed by government employees. The Contracting Officer...

48 CFR 1352.237-72 - Security processing requirements-national security contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... National Security Contracts require contractor employees to gain access to national security information in.... (c) Security procedures. Position sensitivity/risk assessments must be conducted on all functions... same manner as assessment of those functions performed by government employees. The Contracting Officer...

48 CFR 1352.237-72 - Security processing requirements-national security contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... National Security Contracts require contractor employees to gain access to national security information in.... (c) Security procedures. Position sensitivity/risk assessments must be conducted on all functions... same manner as assessment of those functions performed by government employees. The Contracting Officer...

48 CFR 1352.237-72 - Security processing requirements-national security contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... National Security Contracts require contractor employees to gain access to national security information in.... (c) Security Procedures. Position sensitivity/risk assessments must be conducted on all functions... same manner as assessment of those functions performed by government employees. The Contracting Officer...

Electrostatic Effects in Filamentous Protein Aggregation

PubMed Central

Buell, Alexander K.; Hung, Peter; Salvatella, Xavier; Welland, Mark E.; Dobson, Christopher M.; Knowles, Tuomas P.J.

2013-01-01

Electrostatic forces play a key role in mediating interactions between proteins. However, gaining quantitative insights into the complex effects of electrostatics on protein behavior has proved challenging, due to the wide palette of scenarios through which both cations and anions can interact with polypeptide molecules in a specific manner or can result in screening in solution. In this article, we have used a variety of biophysical methods to probe the steady-state kinetics of fibrillar protein self-assembly in a highly quantitative manner to detect how it is modulated by changes in solution ionic strength. Due to the exponential modulation of the reaction rate by electrostatic forces, this reaction represents an exquisitely sensitive probe of these effects in protein-protein interactions. Our approach, which involves a combination of experimental kinetic measurements and theoretical analysis, reveals a hierarchy of electrostatic effects that control protein aggregation. Furthermore, our results provide a highly sensitive method for the estimation of the magnitude of binding of a variety of ions to protein molecules. PMID:23473495

A Butter Aroma Recombinate Activates Human Class-I Odorant Receptors.

PubMed

Geithe, Christiane; Andersen, Gaby; Malki, Agne; Krautwurst, Dietmar

2015-11-04

With ∼400 olfactory G protein-coupled receptors (GPCR), humans sensitively perceive ∼230 key aroma compounds as best natural agonists of ∼10000 food volatiles. An understanding of odorant coding, thus, critically depends on the knowledge about interactions of key food aroma chemicals and their mixtures with their cognate receptors. Genetically designed test cell systems enable the screening, deorphaning, and characterization of single odorant receptors (OR). This study shows for the food aroma-specific and quantitative butter aroma recombinate, and its single components, specific in vitro class-I OR activity patterns, as well as the activation of selected OR in a concentration-dependent manner. Recently, chemosensory receptors, especially class-I OR, were demonstrated to be expressed on blood leukocytes, which may encounter foodborne aroma compounds postprandially. This study shows that butter aroma recombinate induced chemotaxis of isolated human neutrophils in a defined gradient, and in a concentration-dependent and pertussis toxin-sensitive manner, suggesting at least a GPCR-mediated activation of blood leukocytes by key food odorants.

Transferring mixtures of chemicals from sediment to a bioassay using silicone-based passive sampling and dosing.

PubMed

Mustajärvi, Lukas; Eriksson-Wiklund, Ann-Kristin; Gorokhova, Elena; Jahnke, Annika; Sobek, Anna

2017-11-15

Environmental mixtures of chemicals consist of a countless number of compounds with unknown identity and quantity. Yet, chemical regulation is mainly built around the assessment of single chemicals. Existing frameworks for assessing the toxicity of mixtures require that both the chemical composition and quantity are known. Quantitative analyses of the chemical composition of environmental mixtures are however extremely challenging and resource-demanding. Bioassays may therefore serve as a useful approach for investigating the combined toxicity of environmental mixtures of chemicals in a cost-efficient and holistic manner. In this study, an unknown environmental mixture of bioavailable semi-hydrophobic to hydrophobic chemicals was sampled from a contaminated sediment in a coastal Baltic Sea area using silicone polydimethylsiloxane (PDMS) as an equilibrium passive sampler. The chemical mixture was transferred to a PDMS-based passive dosing system, and its applicability was demonstrated using green algae Tetraselmis suecica in a cell viability assay. The proportion of dead cells increased significantly with increasing exposure level and in a dose-response manner. At an ambient concentration, the proportion of dead cells in the population was nearly doubled compared to the control; however, the difference was non-significant due to high inter-replicate variability and a low number of replicates. The validation of the test system regarding equilibrium sampling, loading efficiency into the passive dosing polymer, stability of the mixture composition, and low algal mortality in control treatments demonstrates that combining equilibrium passive sampling and passive dosing is a promising tool for investigating the toxicity of bioavailable semi-hydrophobic and hydrophobic chemicals in complex environmental mixtures.

Destruction of PCB Contaminated Fuel Oil in an Aluminum Melting Furnace

NASA Astrophysics Data System (ADS)

Sonksen, M. K.; Busch, Stephen P.

1985-02-01

Since the 1979 discovery that Alcoa Davenport Works' auxiliary fuel oil supply was contaminated with PCB's, facilities have been provided, and proven, to permit continued use of the oil in a production facility in an environmentally safe manner. This process has several significant benefits. These include energy conservation, with an overall savings of 2.3 × 1011 BTUs and the environmental benefit of destruction of the PCB. The process also eliminates the hazards of transport over long distances.

Final Environmental Assessment Addressing Construction, Operation, and Maintenance of a Hot Cargo Pad at Kirtland Air Force Base, New Mexico

DTIC Science & Technology

2011-01-01

ground surface of the pad. The surface sludge at WP-26 is currently being removed, which would alleviate any potential adverse effects on the...removing and disposing of the top 5 inches of the ground surface , which is potentially contaminated sewage sludge, within WP-26 in a manner consistent...Construction, Operation, and Maintenance of a Hot Cargo Pad at Kirtland Air Force Base, New Mexico, to identifY and evaluate potential environmental effects

Nanomaterials and Global Sustainability.

PubMed

Hamers, Robert J

2017-03-21

Nanomaterials provide tremendous opportunities to advance human welfare in many areas including energy storage, catalysis, photovoltaic energy conversion, environmental remediation, and agriculture. As nanomaterials become incorporated into commercial processes and consumer products in increasing amounts, it will be essential to develop an understanding of how these materials interact with the environment. The broad spectrum and complexity of nanomaterials drive a need for molecular-level design rules. Ultimately a grand challenge is to use the power of chemistry to ensure that nanoenabled technologies can come to fruition in an environmentally benign manner.

Development of an Automatic Differentiation Version of the FPX Rotor Code

NASA Technical Reports Server (NTRS)

Hu, Hong

1996-01-01

The ADIFOR2.0 automatic differentiator is applied to the FPX rotor code along with the grid generator GRGN3. The FPX is an eXtended Full-Potential CFD code for rotor calculations. The automatic differentiation version of the code is obtained, which provides both non-geometry and geometry sensitivity derivatives. The sensitivity derivatives via automatic differentiation are presented and compared with divided difference generated derivatives. The study shows that automatic differentiation method gives accurate derivative values in an efficient manner.

28 CFR 91.63 - Preparing an Environmental Impact Statement

Code of Federal Regulations, 2012 CFR

2012-07-01

... variety of environmental impacts, the sensitive environmental nature of the proposed site, and/or the existence of highly controversial environmental impacts. (b) CEQ regulations. The CEQ regulations in 40 CFR...

28 CFR 91.63 - Preparing an Environmental Impact Statement

Code of Federal Regulations, 2011 CFR

2011-07-01

... variety of environmental impacts, the sensitive environmental nature of the proposed site, and/or the existence of highly controversial environmental impacts. (b) CEQ regulations. The CEQ regulations in 40 CFR...

28 CFR 91.63 - Preparing an Environmental Impact Statement

Code of Federal Regulations, 2014 CFR

2014-07-01

... variety of environmental impacts, the sensitive environmental nature of the proposed site, and/or the existence of highly controversial environmental impacts. (b) CEQ regulations. The CEQ regulations in 40 CFR...

28 CFR 91.63 - Preparing an Environmental Impact Statement

Code of Federal Regulations, 2013 CFR

2013-07-01

... variety of environmental impacts, the sensitive environmental nature of the proposed site, and/or the existence of highly controversial environmental impacts. (b) CEQ regulations. The CEQ regulations in 40 CFR...

INVESTIGATING UNCERTAINTY AND SENSITIVITY IN INTEGRATED MULTIMEDIA ENVIRONMENTAL MODELS: TOOLS FOR 3MRA

EPA Science Inventory

Sufficiently elucidating uncertainty and sensitivity structures in environmental models can be a difficult task, even for low-order, single-media constructs driven by a unique set of site-specific data. The ensuing challenge of examining ever more complex, integrated, higher-ord...

INVESTIGATING UNCERTAINTY AND SENSITIVITY IN INTEGRATED, MULTIMEDIA ENVIRONMENTAL MODELS: TOOLS FOR FRAMES-3MRA

EPA Science Inventory

Elucidating uncertainty and sensitivity structures in environmental models can be a difficult task, even for low-order, single-medium constructs driven by a unique set of site-specific data. Quantitative assessment of integrated, multimedia models that simulate hundreds of sites...

Overview and application of the Model Optimization, Uncertainty, and SEnsitivity Analysis (MOUSE) toolbox

USDA-ARS?s Scientific Manuscript database

For several decades, optimization and sensitivity/uncertainty analysis of environmental models has been the subject of extensive research. Although much progress has been made and sophisticated methods developed, the growing complexity of environmental models to represent real-world systems makes it...

Ultrasonic signal enhancement by resonator techniques

NASA Technical Reports Server (NTRS)

Heyman, J. S.

1973-01-01

Ultrasonic resonators increase experimental sensitivity to acoustic dispersion and changes in attenuation. Experimental sensitivity enhancement line shapes are presented which were obtained by modulating the acoustic properties of a CdS resonator with a light beam. Small changes in light level are made to produce almost pure absorptive or dispersive changes in the resonator signal. This effect is due to the coupling of the ultrasonic wave to the CdS conductivity which is proportional to incident light intensity. The resonator conductivity is adjusted in this manner to obtain both dispersive and absorptive sensitivity enhancement line shapes. The data presented verify previous thoretical calculations based on a propagating wave model.

What do we mean by sensitivity analysis? The need for comprehensive characterization of "global" sensitivity in Earth and Environmental systems models

NASA Astrophysics Data System (ADS)

Razavi, Saman; Gupta, Hoshin V.

2015-05-01

Sensitivity analysis is an essential paradigm in Earth and Environmental Systems modeling. However, the term "sensitivity" has a clear definition, based in partial derivatives, only when specified locally around a particular point (e.g., optimal solution) in the problem space. Accordingly, no unique definition exists for "global sensitivity" across the problem space, when considering one or more model responses to different factors such as model parameters or forcings. A variety of approaches have been proposed for global sensitivity analysis, based on different philosophies and theories, and each of these formally characterizes a different "intuitive" understanding of sensitivity. These approaches focus on different properties of the model response at a fundamental level and may therefore lead to different (even conflicting) conclusions about the underlying sensitivities. Here we revisit the theoretical basis for sensitivity analysis, summarize and critically evaluate existing approaches in the literature, and demonstrate their flaws and shortcomings through conceptual examples. We also demonstrate the difficulty involved in interpreting "global" interaction effects, which may undermine the value of existing interpretive approaches. With this background, we identify several important properties of response surfaces that are associated with the understanding and interpretation of sensitivities in the context of Earth and Environmental System models. Finally, we highlight the need for a new, comprehensive framework for sensitivity analysis that effectively characterizes all of the important sensitivity-related properties of model response surfaces.

36 CFR 1010.12 - Public involvement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Section 1010.12 Parks, Forests, and Public Property PRESIDIO TRUST ENVIRONMENTAL QUALITY § 1010.12 Public... announcements in the Trust's monthly newsletter, postings on its web site (www.presidiotrust.gov), placement of... public scoping meetings will be given in a timely manner. Interested persons may also obtain information...

36 CFR 1010.12 - Public involvement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Section 1010.12 Parks, Forests, and Public Property PRESIDIO TRUST ENVIRONMENTAL QUALITY § 1010.12 Public... announcements in the Trust's monthly newsletter, postings on its web site (www.presidiotrust.gov), placement of... public scoping meetings will be given in a timely manner. Interested persons may also obtain information...

D-OPTIMAL EXPERIMENTAL DESIGNS TO TEST FOR DEPARTURE FROM ADDITIVITY IN A FIXED-RATIO MIXTURE RAY.

EPA Science Inventory

Humans are exposed to mixtures of environmental compounds. A regulatory assumption is that the mixtures of chemicals act in an additive manner. However, this assumption requires experimental validation. Traditional experimental designs (full factorial) require a large number of e...

40 CFR 240.209-1 - Requirement.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... Incinerators shall be designed, operated, and maintained in a manner to protect the health and safety of... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Requirement. 240.209-1 Section 240.209-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

40 CFR 240.209-1 - Requirement.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... Incinerators shall be designed, operated, and maintained in a manner to protect the health and safety of... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Requirement. 240.209-1 Section 240.209-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

40 CFR 240.209-1 - Requirement.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... Incinerators shall be designed, operated, and maintained in a manner to protect the health and safety of... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Requirement. 240.209-1 Section 240.209-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

40 CFR 240.209-1 - Requirement.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... Incinerators shall be designed, operated, and maintained in a manner to protect the health and safety of... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Requirement. 240.209-1 Section 240.209-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

40 CFR 240.209-1 - Requirement.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Incinerators shall be designed, operated, and maintained in a manner to protect the health and safety of... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Requirement. 240.209-1 Section 240.209-1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES GUIDELINES FOR...

40 CFR 721.5800 - Sulfurized alkylphenol.

Code of Federal Regulations, 2010 CFR

2010-07-01

... information on methods for protecting against such risk, into an MSDS as described in § 721.72(c) within 90... Section 721.5800 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... substance is any manner or method of manufacture, import, or processing associated with any use of this...

40 CFR 721.5450 - α-Olefin sulfonate, sodium salt.

Code of Federal Regulations, 2010 CFR

2010-07-01

... this new information, and any information on methods for protecting against such risk, into an MSDS as....5450 Section 721.5450 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... significant new use of this substance is any manner or method of manufacture, import, or processing associated...

40 CFR 721.5546 - Halogen substituted oxetanes (generic).

Code of Federal Regulations, 2010 CFR

2010-07-01

..., and any information on methods for protecting against such risk, into a Material Safety Data Sheet...). 721.5546 Section 721.5546 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... program. A significant new use of these chemical substances is any manner or method of manufacture, import...

40 CFR 721.3860 - Glycol monobenzoate.

Code of Federal Regulations, 2010 CFR

2010-07-01

... information on methods for protecting against such risk, into an MSDS as described in § 721.72(c) within 90... 721.3860 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... substance is any manner or method of manufacture, import, or processing associated with any use of this...

40 CFR 721.5980 - Dialkyl phosphorodithioate phosphate compounds.

Code of Federal Regulations, 2010 CFR

2010-07-01

... any information on methods for protecting against such risk, into an MSDS as described at § 721.72(c... compounds. 721.5980 Section 721.5980 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... manner or method of manufacture, import, or processing associated with any use of these substances...

75 FR 22127 - Notice of Data Availability Concerning 2010 CAIR NOX

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-27

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9142-3] Notice of Data Availability Concerning 2010 CAIR NOX... viruses. FOR FURTHER INFORMATION CONTACT: Questions concerning this action should be addressed to Robert L... objection. However, objections may be submitted concerning whether EPA determined, in a manner consistent...

A Rationale for Developmental Testing and Training.

ERIC Educational Resources Information Center

Arner, Robert S.

Man's phylogenetic development has resulted in a potential for environmental interaction in a symbolic and conceptual manner. There are ontogenetic requirements to develop such potential. The process by which man learns is sequential and involves perceptual-motor-cognitive abilities. There is an optimum respectivity period at each developmental…

36 CFR 1010.12 - Public involvement.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Section 1010.12 Parks, Forests, and Public Property PRESIDIO TRUST ENVIRONMENTAL QUALITY § 1010.12 Public... announcements in the Trust's monthly newsletter, postings on its web site (www.presidiotrust.gov), placement of... public scoping meetings will be given in a timely manner. Interested persons may also obtain information...

36 CFR 1010.12 - Public involvement.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Section 1010.12 Parks, Forests, and Public Property PRESIDIO TRUST ENVIRONMENTAL QUALITY § 1010.12 Public... announcements in the Trust's monthly newsletter, postings on its web site (www.presidiotrust.gov), placement of... public scoping meetings will be given in a timely manner. Interested persons may also obtain information...

Spent Nuclear Fuel (SNF) Project Execution Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

LEROY, P.G.

2000-11-03

The Spent Nuclear Fuel (SNF) Project supports the Hanford Site Mission to cleanup the Site by providing safe, economic, environmentally sound management of Site spent nuclear fuel in a manner that reduces hazards by staging it to interim onsite storage and deactivates the 100 K Area facilities.

40 CFR 303.30 - Criteria for payment of award.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Criteria for payment of award. 303.30 Section 303.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY... have obtained knowledge of the violation in a timely manner absent claimant's information; (c...

BDNF rs6265 methylation and genotype interact on risk for schizophrenia

PubMed Central

Ursini, Gianluca; Cavalleri, Tommaso; Fazio, Leonardo; Angrisano, Tiziana; Iacovelli, Luisa; Porcelli, Annamaria; Maddalena, Giancarlo; Punzi, Giovanna; Mancini, Marina; Gelao, Barbara; Romano, Raffaella; Masellis, Rita; Calabrese, Francesca; Rampino, Antonio; Taurisano, Paolo; Giorgio, Annabella Di; Keller, Simona; Tarantini, Letizia; Sinibaldi, Lorenzo; Quarto, Tiziana; Popolizio, Teresa; Caforio, Grazia; Blasi, Giuseppe; Riva, Marco A.; De Blasi, Antonio; Chiariotti, Lorenzo; Bollati, Valentina; Bertolino, Alessandro

2016-01-01

Abstract Epigenetic mechanisms can mediate gene-environment interactions relevant for complex disorders. The BDNF gene is crucial for development and brain plasticity, is sensitive to environmental stressors, such as hypoxia, and harbors the functional SNP rs6265 (Val66Met), which creates or abolishes a CpG dinucleotide for DNA methylation. We found that methylation at the BDNF rs6265 Val allele in peripheral blood of healthy subjects is associated with hypoxia-related early life events (hOCs) and intermediate phenotypes for schizophrenia in a distinctive manner, depending on rs6265 genotype: in ValVal individuals increased methylation is associated with exposure to hOCs and impaired working memory (WM) accuracy, while the opposite is true for ValMet subjects. Also, rs6265 methylation and hOCs interact in modulating WM-related prefrontal activity, another intermediate phenotype for schizophrenia, with an analogous opposite direction in the 2 genotypes. Consistently, rs6265 methylation has a different association with schizophrenia risk in ValVals and ValMets. The relationships of methylation with BDNF levels and of genotype with BHLHB2 binding likely contribute to these opposite effects of methylation. We conclude that BDNF rs6265 methylation interacts with genotype to bridge early environmental exposures to adult phenotypes, relevant for schizophrenia. The study of epigenetic changes in regions containing genetic variation relevant for human diseases may have beneficial implications for the understanding of how genes are actually translated into phenotypes. PMID:26889735

The nature of context-sensitive solutions, stakeholder involvement and critical issues in the urban context : [research brief].

DOT National Transportation Integrated Search

2011-12-01

Over the last several decades many transportation and planning agencies have experienced conflicting demands emerging from the need to develop projects in an expeditious manner while at the same time involving stakeholders in the decision-making proc...

SKIP Is a Component of the Spliceosome Linking Alternative Splicing and the Circadian Clock in Arabidopsis[W

PubMed Central

Wang, Xiaoxue; Wu, Fangming; Xie, Qiguang; Wang, Huamei; Wang, Ying; Yue, Yanling; Gahura, Ondrej; Ma, Shuangshuang; Liu, Lei; Cao, Ying; Jiao, Yuling; Puta, Frantisek; McClung, C. Robertson; Xu, Xiaodong; Ma, Ligeng

2012-01-01

Circadian clocks generate endogenous rhythms in most organisms from cyanobacteria to humans and facilitate entrainment to environmental diurnal cycles, thus conferring a fitness advantage. Both transcriptional and posttranslational mechanisms are prominent in the basic network architecture of circadian systems. Posttranscriptional regulation, including mRNA processing, is emerging as a critical step for clock function. However, little is known about the molecular mechanisms linking RNA metabolism to the circadian clock network. Here, we report that a conserved SNW/Ski-interacting protein (SKIP) domain protein, SKIP, a splicing factor and component of the spliceosome, is involved in posttranscriptional regulation of circadian clock genes in Arabidopsis thaliana. Mutation in SKIP lengthens the circadian period in a temperature-sensitive manner and affects light input and the sensitivity of the clock to light resetting. SKIP physically interacts with the spliceosomal splicing factor Ser/Arg-rich protein45 and associates with the pre-mRNA of clock genes, such as PSEUDORESPONSE REGULATOR7 (PRR7) and PRR9, and is necessary for the regulation of their alternative splicing and mRNA maturation. Genome-wide investigations reveal that SKIP functions in regulating alternative splicing of many genes, presumably through modulating recognition or cleavage of 5′ and 3′ splice donor and acceptor sites. Our study addresses a fundamental question on how the mRNA splicing machinery contributes to circadian clock function at a posttranscriptional level. PMID:22942380

Parallel Computing and Model Evaluation for Environmental Systems: An Overview of the Supermuse and Frames Software Technologies

EPA Science Inventory

ERD’s Supercomputer for Model Uncertainty and Sensitivity Evaluation (SuperMUSE) is a key to enhancing quality assurance in environmental models and applications. Uncertainty analysis and sensitivity analysis remain critical, though often overlooked steps in the development and e...

Sensitivity of cell-based biosensors to environmental variables.

PubMed

Gilchrist, Kristin H; Giovangrandi, Laurent; Whittington, R Hollis; Kovacs, Gregory T A

2005-01-15

Electrically active living cells cultured on extracellular electrode arrays are utilized to detect biologically active agents. Because cells are highly sensitive to environmental conditions, environmental fluctuations can elicit cellular responses that contribute to the noise in a cell-based biosensor system. Therefore, the characterization and control of environmental factors such as temperature, pH, and osmolarity is critical in such a system. The cell-based biosensor platform described here utilizes the measurement of action potentials from cardiac cells cultured on electrode arrays. A recirculating fluid flow system is presented for use in dose-response experiments that regulates temperature within +/-0.2 degrees C, pH to within +/-0.05 units, and allows no significant change in osmolarity. Using this system, the relationship between the sensor output parameters and environmental variation was quantified. Under typical experimental conditions, beat rate varied approximately 10% per degree change in temperature or per 0.1 unit change in pH. Similar relationships were measured for action potential amplitude, duration, and conduction velocity. For the specific flow system used in this work, the measured environmental sensitivity resulted in an overall beat rate variation of +/-4.7% and an overall amplitude variation of +/-3.3%. The magnitude of the noise due to environmental sensitivity has a large impact on the detection capability of the cell-based system. The significant responses to temperature, pH, and osmolarity have important implications for the use of living cells in detection systems and should be considered in the design and evaluation of such systems.

Social Networking and Smart Technology: Viable Environmental Communication Tools…?

NASA Astrophysics Data System (ADS)

Montain, J.; Byrne, J. M.

2010-12-01

To what extent do popular social networking channels represent a viable means for disseminating information regarding environmental change to the general public? Are new forms of communication such as YouTube™, Facebook™, MySpace™ and Twitter™ and smart devices such as iPhone™ and BlackBerry™ useful and effective in terms motivating people into social action and behavioural modification; or do they simply pay ‘lip service’ to these pressing environmental issues? This project will explore the background connections between social networking and environmental communication and education; and outline why such tools might be an appropriate way to connect to a broad audience in an efficient and unconventional manner. Further, research will survey the current prevalence of reliable environmental change information on social networking Internet-based media; and finally, suggestions for improved strategies and new directions will be provided.

Phloretin differentially inhibits volume-sensitive and cyclic AMP-activated, but not Ca-activated, Cl− channels

PubMed Central

Fan, Hai-Tian; Morishima, Shigeru; Kida, Hajime; Okada, Yasunobu

2001-01-01

Some phenol derivatives are known to block volume-sensitive Cl− channels. However, effects on the channel of the bisphenol phloretin, which is a known blocker of glucose uniport and anion antiport, have not been examined. In the present study, we investigated the effects of phloretin on volume-sensitive Cl− channels in comparison with cyclic AMP-activated CFTR Cl− channels and Ca2+-activated Cl− channels using the whole-cell patch-clamp technique.Extracellular application of phloretin (over 10 μM) voltage-independently, and in a concentration-dependent manner (IC50 ∼30 μM), inhibited the Cl− current activated by a hypotonic challenge in human epithelial T84, Intestine 407 cells and mouse mammary C127/CFTR cells.In contrast, at 30 μM phloretin failed to inhibit cyclic AMP-activated Cl− currents in T84 and C127/CFTR cells. Higher concentrations (over 100 μM) of phloretin, however, partially inhibited the CFTR Cl− currents in a voltage-dependent manner.At 30 and 300 μM, phloretin showed no inhibitory effect on Ca2+-dependent Cl− currents induced by ionomycin in T84 cells.It is concluded that phloretin preferentially blocks volume-sensitive Cl− channels at low concentrations (below 100 μM) and also inhibits cyclic AMP-activated Cl− channels at higher concentrations, whereas phloretin does not inhibit Ca2+-activated Cl− channels in epithelial cells. PMID:11487521

Strategic environmental assessment in China: motivations, politics, and effectiveness.

PubMed

Zhu, Da; Ru, Jiang

2008-09-01

This paper examines how strategic environmental assessment has been practiced at the national level in China through 2005 and why it has been practiced in the manner observed. Based on literature reviews and interviews carried out in 2005 and 2006, we find that bureaucratic politics between environmental and nonenvironmental ministries has limited the legislation and implementation of strategic environmental assessment to environmental assessment (EA) for a set of government plans defined in the 2003 Environmental Impact Assessment Law. Interviewees from environmental and nonenvironmental ministries and key research institutes have reported that few planning EAs have been performed at the sectoral level. Nonenvironmental ministries have either evaded the 2003 Environmental Impact Assessment Law and have not undertaken required planning EA or have organized planning EA on their own without participation by the State Environmental Protection Administration. The rising tension between the environmental and nonenvironmental ministries has limited the role of planning EA as a participatory decision-making tool. In addition to bureaucratic politics, we find that weak public participation and underemphasis on social analysis in planning EA may have further compromised the utility of planning EA.

Student Preparation Workbook for Outdoor School Attendance.

ERIC Educational Resources Information Center

Gilfillan, Warren C.; And Others

Sixth grade students can prepare for the Multnomah County, Oregon, Outdoor School experience by completing the workbook designed to provide fundamental information about soil, water, plant, and animal resources. The workbook begins with an introduction to environmental manners, after which a section is devoted to each resource area. The glossary…

36 CFR § 1010.12 - Public involvement.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section § 1010.12 Parks, Forests, and Public Property PRESIDIO TRUST ENVIRONMENTAL QUALITY § 1010.12... announcements in the Trust's monthly newsletter, postings on its web site (www.presidiotrust.gov), placement of... public scoping meetings will be given in a timely manner. Interested persons may also obtain information...

40 CFR 142.78 - Procedure for processing an Indian Tribe's application.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Tribe's application. 142.78 Section 142.78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Tribes § 142.78 Procedure for processing an Indian Tribe's application. (a) The Administrator shall process a completed application of an Indian Tribe in a timely manner. He shall promptly notify the Indian...

40 CFR 123.33 - Procedures for processing an Indian Tribe's application.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Tribe's application. 123.33 Section 123.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... processing an Indian Tribe's application. (a) The Regional Administrator shall process an application of an Indian Tribe submitted pursuant to § 123.32 in a timely manner. He shall promptly notify the Indian Tribe...

40 CFR 142.78 - Procedure for processing an Indian Tribe's application.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Tribe's application. 142.78 Section 142.78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Tribes § 142.78 Procedure for processing an Indian Tribe's application. (a) The Administrator shall process a completed application of an Indian Tribe in a timely manner. He shall promptly notify the Indian...

40 CFR 123.33 - Procedures for processing an Indian Tribe's application.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Tribe's application. 123.33 Section 123.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... processing an Indian Tribe's application. (a) The Regional Administrator shall process an application of an Indian Tribe submitted pursuant to § 123.32 in a timely manner. He shall promptly notify the Indian Tribe...

40 CFR 501.24 - Procedures for processing an Indian Tribe's application.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Tribe's application. 501.24 Section 501.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Programs § 501.24 Procedures for processing an Indian Tribe's application. (a) The Regional Administrator shall process an application of an Indian Tribe submitted pursuant to § 501.23 in a timely manner. He...

40 CFR 123.33 - Procedures for processing an Indian Tribe's application.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Tribe's application. 123.33 Section 123.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... processing an Indian Tribe's application. (a) The Regional Administrator shall process an application of an Indian Tribe submitted pursuant to § 123.32 in a timely manner. He shall promptly notify the Indian Tribe...

40 CFR 501.24 - Procedures for processing an Indian Tribe's application.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Tribe's application. 501.24 Section 501.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Programs § 501.24 Procedures for processing an Indian Tribe's application. (a) The Regional Administrator shall process an application of an Indian Tribe submitted pursuant to § 501.23 in a timely manner. He...

40 CFR 501.24 - Procedures for processing an Indian Tribe's application.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Tribe's application. 501.24 Section 501.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Programs § 501.24 Procedures for processing an Indian Tribe's application. (a) The Regional Administrator shall process an application of an Indian Tribe submitted pursuant to § 501.23 in a timely manner. He...

40 CFR 142.78 - Procedure for processing an Indian Tribe's application.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Tribe's application. 142.78 Section 142.78 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Tribes § 142.78 Procedure for processing an Indian Tribe's application. (a) The Administrator shall process a completed application of an Indian Tribe in a timely manner. He shall promptly notify the Indian...

40 CFR 501.24 - Procedures for processing an Indian Tribe's application.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Tribe's application. 501.24 Section 501.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Programs § 501.24 Procedures for processing an Indian Tribe's application. (a) The Regional Administrator shall process an application of an Indian Tribe submitted pursuant to § 501.23 in a timely manner. He...

40 CFR 501.24 - Procedures for processing an Indian Tribe's application.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Tribe's application. 501.24 Section 501.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Programs § 501.24 Procedures for processing an Indian Tribe's application. (a) The Regional Administrator shall process an application of an Indian Tribe submitted pursuant to § 501.23 in a timely manner. He...

40 CFR 123.33 - Procedures for processing an Indian Tribe's application.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Tribe's application. 123.33 Section 123.33 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... processing an Indian Tribe's application. (a) The Regional Administrator shall process an application of an Indian Tribe submitted pursuant to § 123.32 in a timely manner. He shall promptly notify the Indian Tribe...

Waste Controls at Base Metal Mines

ERIC Educational Resources Information Center

Bell, Alan V.

1976-01-01

Mining and milling of copper, lead, zinc and nickel in Canada involves an accumulation of a half-million tons of waste material each day and requires 250 million gallons of process water daily. Waste management considerations for handling large volumes of wastes in an economically and environmentally safe manner are discussed. (BT)

Real-World Writing in a Secondary-School Earth-Science Class.

ERIC Educational Resources Information Center

Millette, Patricia Marie

1991-01-01

Author describes how 22 first-year high school students became politically active concerning coastal-zone management and wetlands protection. Students translated regulations of the Maine Department of Environmental Protection into plain English. Students wrote their opinions in a concise manner and appeared at a board meeting to influence its…

INTEGRATION OF MECHANISTIC DATA INTO THE WEIGHT EVIDENCE CONSIDERATIONS FOR RISK ASSESSMENT OF DEVELOPMENTAL EXPOSURE TO CHLORPYRIFOS.

EPA Science Inventory

The susceptibility of the developing nervous system to damage following exposure to environmental contaminants is believed to be based upon the critical nature of the organizational events that occur in both a regionally- and temporally-dependent manner. The age-related susceptib...

Case Study: Fuel Cells Provide Combined Heat and Power at Verizon's Garden City Central Office

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-12-01

This case study describes how Verizon's Central Office in Garden City, NY, installed a 1.4-MW phosphoric acid fuel cell system as an alternative solution to bolster electric reliability, optimize the company's energy use, and reduce costs in an environmentally responsible manner.

40 CFR 63.1159 - Operational and equipment standards for existing, new, or reconstructed sources.

Code of Federal Regulations, 2014 CFR

2014-07-01

... atmosphere shall be equipped with a local fume capture system, ventilated through an air pollution control... pollution control equipment and monitoring equipment in a manner consistent with safety and good air... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS...

40 CFR 63.1159 - Operational and equipment standards for existing, new, or reconstructed sources.

Code of Federal Regulations, 2013 CFR

2013-07-01

... atmosphere shall be equipped with a local fume capture system, ventilated through an air pollution control... pollution control equipment and monitoring equipment in a manner consistent with safety and good air... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS...

40 CFR 721.1650 - Alkylbenzenesulfonic acid and sodium salts.

Code of Federal Regulations, 2010 CFR

2010-07-01

... information on methods for protecting against such risk, into an MSDS as described in § 721.72(c) within 90... salts. 721.1650 Section 721.1650 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... substance is any manner or method of manufacture, import, or processing associated with any use of this...

40 CFR 721.4380 - Modified hydrocarbon resin.

Code of Federal Regulations, 2010 CFR

2010-07-01

... information on methods for protecting against such risk, into an MSDS as described in § 721.72(c) within 90... Section 721.4380 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... substance is any manner or method of manufacture, import, or processing associated with any use of this...

40 CFR 721.7500 - Nitrate polyether polyol (generic name).

Code of Federal Regulations, 2010 CFR

2010-07-01

... information on methods for protecting against such risk, into a Material Safety Data Sheet (MSDS) as described...). 721.7500 Section 721.7500 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC... substance is any manner or method of manufacture, import, or processing associated with any use of this...

40 CFR 165.90 - Operational, inspection and maintenance requirements for all new and existing containment...

Code of Federal Regulations, 2012 CFR

2012-07-01

... recovered in a manner that ensures protection of human health and the environment (including surface water... to human health or the environment. (3) Ensure that all materials resulting from spills and leaks and... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE MANAGEMENT AND DISPOSAL...

40 CFR 165.90 - Operational, inspection and maintenance requirements for all new and existing containment...

Code of Federal Regulations, 2014 CFR

2014-07-01

... recovered in a manner that ensures protection of human health and the environment (including surface water... to human health or the environment. (3) Ensure that all materials resulting from spills and leaks and... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE MANAGEMENT AND DISPOSAL...

40 CFR 165.90 - Operational, inspection and maintenance requirements for all new and existing containment...

Code of Federal Regulations, 2011 CFR

2011-07-01

... recovered in a manner that ensures protection of human health and the environment (including surface water... to human health or the environment. (3) Ensure that all materials resulting from spills and leaks and... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE MANAGEMENT AND DISPOSAL...

40 CFR 165.90 - Operational, inspection and maintenance requirements for all new and existing containment...

Code of Federal Regulations, 2013 CFR

2013-07-01

... recovered in a manner that ensures protection of human health and the environment (including surface water... to human health or the environment. (3) Ensure that all materials resulting from spills and leaks and... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE MANAGEMENT AND DISPOSAL...

40 CFR 165.90 - Operational, inspection and maintenance requirements for all new and existing containment...

Code of Federal Regulations, 2010 CFR

2010-07-01

... recovered in a manner that ensures protection of human health and the environment (including surface water... to human health or the environment. (3) Ensure that all materials resulting from spills and leaks and... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE MANAGEMENT AND DISPOSAL...

Maternal air pollution exposure induces fetal neuroinflammation and predisposes offspring to obesity in aduthood in a sex-specific manner

EPA Science Inventory

Emerging evidence suggests environmental chemical exposures during critical windows of development may contribute to the escalating prevalence of obesity. We tested the hypothesis that prenatal air pollution exposure would predispose the offspring to weight gain in adulthood. Pre...

Evaluating Eco-Innovation of OECD Countries with Data Envelopment Analysis

ERIC Educational Resources Information Center

Mavi, Reza Kiani; Standing, Craig

2016-01-01

Government regulations require businesses to improve their processes and products/services in a green and sustainable manner. For being environmentally friendly, businesses should invest more on eco-innovation practices. Firms eco-innovate to promote eco-efficiency and sustainability. This paper evaluates the eco-innovation performance of…

Safety in the Chemical Laboratory: Contracts to Dispose of Laboratory Waste.

ERIC Educational Resources Information Center

Fischer, Kenneth E.

1985-01-01

Presents a sample contract for disposing of hazardous wastes in an environmentally sound, timely manner in accordance with all federal, state, and local requirements. Addresses situations where hazardous waste must be disposed of outside the laboratory and where alternate disposal methods are not feasible. (JN)

Demonstration of Green/Gray Infrastructure for Combined Sewer Overflow Control

EPA Science Inventory

This project is a major national demonstration of the integration of green and gray infrastructure for combined sewer overflow (CSO) control in a cost-effective and environmentally friendly manner. It will use Kansas City, MO, as a case example. The project will have a major in...

Student Preparation Workbook for the Multnomah Outdoor School. Teacher Edition. Revised.

ERIC Educational Resources Information Center

Bohm, Rudy; Cole, Wally

Designed for use by sixth grade teachers in preparing their classes for the Multnomah County (Oregon) Outdoor School experience, the guide to the Student Preparation Workbook provides general information, descriptions, game materials, and answers to the exercises and puzzles. Beginning with an introduction to environmental manners (rules for…

Controlling the Thermal Environment of the Co-ordinated Classroom.

ERIC Educational Resources Information Center

Harmon, Darell Boyd

The classroom environment is a working surround in which children, through participating in organized experiences, can grow and develop in an optimum manner. Classroom design requires organization of principles of environmental control in order to assure efficient and successful performance. This control cannot be left to chance. In considering…

The GLIMPSE project: Exploring strategies for meeting energy, environmental and climate objectives

EPA Science Inventory

Many of Chinas cities are struggling with high levels of air pollution. At the same time, Chinese planners are seeking to meet growing demands for energy in a manner that meets climate goals. In this presentation, Dr. Loughlin describes the linkages between energy, the environmen...

Deliberative Democracy, Participation, and OECD Peer Reviews of Environmental Policies

ERIC Educational Resources Information Center

Lehtonen, Markku

2006-01-01

Deliberative democracy has attracted increasing attention in political science and has been suggested as a normative ideal for evaluation. This article analyzes to what extent evaluations carried out in a highly government-driven manner can nevertheless contribute to deliberative democracy. This potential is examined by taking the Organisation for…

40 CFR 721.30 - EPA approval of alternative control measures.

Code of Federal Regulations, 2013 CFR

2013-07-01

...), must submit the request to EPA via EPA's Central Data Exchange (CDX) using EPA-provided e-PMN software... obtain e-PMN software. Support documents related to these requests must be submitted in the manner set... involved. (5) The specifications of the alternative worker exposure control measures or environmental...

40 CFR 721.30 - EPA approval of alternative control measures.

Code of Federal Regulations, 2011 CFR

2011-07-01

...), must submit the request to EPA via EPA's Central Data Exchange (CDX) using EPA-provided e-PMN software... obtain e-PMN software. Support documents related to these requests must be submitted in the manner set... involved. (5) The specifications of the alternative worker exposure control measures or environmental...

40 CFR 721.30 - EPA approval of alternative control measures.

Code of Federal Regulations, 2012 CFR

2012-07-01

...), must submit the request to EPA via EPA's Central Data Exchange (CDX) using EPA-provided e-PMN software... obtain e-PMN software. Support documents related to these requests must be submitted in the manner set... involved. (5) The specifications of the alternative worker exposure control measures or environmental...

Death: Realism in Children's Books.

ERIC Educational Resources Information Center

Danielson, Kathy Everts

In the past, books for children treated death fearfully, morbidly, and didactically, but now children's literature treats death in a more realistic manner and is sensitive to its emotional aspects. Current theories suggest that children perceive death differently at various ages. G. P. Koocher (1973) used J. Piaget's cognitive stages as the basis…

Interactive Controls Analysis (INCA)

NASA Technical Reports Server (NTRS)

Bauer, Frank H.

1989-01-01

Version 3.12 of INCA provides user-friendly environment for design and analysis of linear control systems. System configuration and parameters easily adjusted, enabling INCA user to create compensation networks and perform sensitivity analysis in convenient manner. Full complement of graphical routines makes output easy to understand. Written in Pascal and FORTRAN.

Working with Hindu Clients in a Spiritually Sensitive Manner

ERIC Educational Resources Information Center

Hodge, David R.

2004-01-01

Although social work is witnessing growing interest in spiritual and religious issues, little guidance has appeared in the literature to assist practitioners in addressing the unique spirituality of rapidly increasing non-Western populations. This article discusses the significant cultural/spiritual beliefs, practices, and values of Hindus, the…

Infusing End-of-Life Issues into the Rehabilitation Counselor Education Curriculum

ERIC Educational Resources Information Center

Wadsworth, John; Harley, Debra; Smith, S. Mae; Kampfe, Charlene

2008-01-01

Rehabilitation counselors are assisting consumers with end-of-life issues. Counselors who have the capacity to assist with end-of-life issues in a culturally sensitive manner possess pre-established self-care networks, an understanding of death from multiple perspectives, knowledge of communication interventions, and appropriate outcome…

A Culturally Competent Immersion Protocol: Petit Goâve, Haiti

ERIC Educational Resources Information Center

Streets, Barbara Faye; Wolford, Karen; Nicolas, Guerda

2015-01-01

In the human services professions, cultural immersion experiences help satisfy multicultural training standards established by national accreditation bodies. Immersion in a culturally sensitive manner is necessary as we prepare professionals to work with and serve citizens of the globe. The authors describe an international cultural immersion…

MONITORING ASPERGILLUS SPECIES BY QUANTITATIVE PCR DURING CONSTRUCTION OF A MULTI-STORY HOSPITAL BUILDING

EPA Science Inventory

Noscomial fungal infections represent a persistent threat in hospitals. One of the major issues in fungal control has been monitoring these fungi in a timely manner. Quantitative polymerase chain reaction (QPCR) allows for the rapid (2 to 4 h), sensitive (often down to a single...

Environmental sensitivity: equivocal illness in the context of place.

PubMed

Fletcher, Christopher M

2006-03-01

This article presents a phenomenologically oriented description of the interaction of illness experience, social context, and place. This is used to explore an outbreak of environmental sensitivities in Nova Scotia, Canada. Environmental Sensitivity (ES) is a popular designation for bodily reactions to mundane environmental stimuli that are insignificant for most people. Mainstream medicine cannot support the popular models of this disease process and consequently illness experience is subject to ambiguity and contestation. As an 'equivocal illness', ES generates considerable social action around the nature, meaning and validity of suffering. Sense of place plays an important role in this process. In this case, the meanings that accrue to illness experience and that produce salient popular disease etiology are grounded in the experience and social construction of the Nova Scotian landscape over time. Shifting representations of place are reflected in illness experience and the meanings that arise around illness are emplaced in landscape.

Membrane depolarization-induced RhoA/Rho-associated kinase activation and sustained contraction of rat caudal arterial smooth muscle involves genistein-sensitive tyrosine phosphorylation

PubMed Central

Mita, Mitsuo; Tanaka, Hitoshi; Yanagihara, Hayato; Nakagawa, Jun-ichi; Hishinuma, Shigeru; Sutherland, Cindy; Walsh, Michael P.; Shoji, Masaru

2013-01-01

Rho-associated kinase (ROK) activation plays an important role in K+-induced contraction of rat caudal arterial smooth muscle (Mita et al., Biochem J. 2002; 364: 431–40). The present study investigated a potential role for tyrosine kinase activity in K+-induced RhoA activation and contraction. The non-selective tyrosine kinase inhibitor genistein, but not the src family tyrosine kinase inhibitor PP2, inhibited K+-induced sustained contraction (IC50 = 11.3 ± 2.4 µM). Genistein (10 µM) inhibited the K+-induced increase in myosin light chain (LC20) phosphorylation without affecting the Ca2+ transient. The tyrosine phosphatase inhibitor vanadate induced contraction that was reversed by genistein (IC50 = 6.5 ± 2.3 µM) and the ROK inhibitor Y-27632 (IC50 = 0.27 ± 0.04 µM). Vanadate also increased LC20 phosphorylation in a genistein- and Y-27632-dependent manner. K+ stimulation induced translocation of RhoA to the membrane, which was inhibited by genistein. Phosphorylation of MYPT1 (myosin-targeting subunit of myosin light chain phosphatase) was significantly increased at Thr855 and Thr697 by K+ stimulation in a genistein- and Y-27632-sensitive manner. Finally, K+ stimulation induced genistein-sensitive tyrosine phosphorylation of proteins of ∼55, 70 and 113 kDa. We conclude that a genistein-sensitive tyrosine kinase, activated by the membrane depolarization-induced increase in [Ca2+]i, is involved in the RhoA/ROK activation and sustained contraction induced by K+. Ca2+ sensitization, myosin light chain phosphatase, RhoA, Rho-associated kinase, tyrosine kinase PMID:24133693

The Insensitive Ruins It All: Compositional and Compilational Influences of Social Sensitivity on Collective Intelligence in Groups.

PubMed

Meslec, Nicoleta; Aggarwal, Ishani; Curseu, Petru L

2016-01-01

A group's collective intelligence reflects its capacity to perform well across a variety of cognitive tasks and it transcends the individual intelligence of its members. Previous research shows that group members' social sensitivity is a potential antecedent of collective intelligence, yet it is still unclear whether individual or group-level indices are responsible for the positive association between social sensitivity and collective intelligence. In a comprehensive manner, we test the extent to which both compositional (lowest and highest individual score) and compilational aspects (emergent group level) of social sensitivity are associated with collective intelligence. This study has implications for research that explores groups as information processors, and for group design as it indicates how a group should be composed with respect to social sensitivity if the group is to reach high levels of collective intelligence. Our empirical results indicate that collectively intelligent groups are those in which the least socially sensitive group member has a rather high score on social sensitivity. Differently stated, (socially sensitive) group members cannot compensate for the lack of social sensitivity of the other group members.

Environmental health indicators of climate change for the United States: findings from the State Environmental Health Indicator Collaborative.

PubMed

English, Paul B; Sinclair, Amber H; Ross, Zev; Anderson, Henry; Boothe, Vicki; Davis, Christine; Ebi, Kristie; Kagey, Betsy; Malecki, Kristen; Shultz, Rebecca; Simms, Erin

2009-11-01

To develop public health adaptation strategies and to project the impacts of climate change on human health, indicators of vulnerability and preparedness along with accurate surveillance data on climate-sensitive health outcomes are needed. We researched and developed environmental health indicators for inputs into human health vulnerability assessments for climate change and to propose public health preventative actions. We conducted a review of the scientific literature to identify outcomes and actions that were related to climate change. Data sources included governmental and nongovernmental agencies and the published literature. Sources were identified and assessed for completeness, usability, and accuracy. Priority was then given to identifying longitudinal data sets that were applicable at the state and community level. We present a list of surveillance indicators for practitioners and policy makers that include climate-sensitive health outcomes and environmental and vulnerability indicators, as well as mitigation, adaptation, and policy indicators of climate change. A review of environmental health indicators for climate change shows that data exist for many of these measures, but more evaluation of their sensitivity and usefulness is needed. Further attention is necessary to increase data quality and availability and to develop new surveillance databases, especially for climate-sensitive morbidity.

Environmental Health Indicators of Climate Change for the United States: Findings from the State Environmental Health Indicator Collaborative

PubMed Central

English, Paul B.; Sinclair, Amber H.; Ross, Zev; Anderson, Henry; Boothe, Vicki; Davis, Christine; Ebi, Kristie; Kagey, Betsy; Malecki, Kristen; Shultz, Rebecca; Simms, Erin

2009-01-01

Objective To develop public health adaptation strategies and to project the impacts of climate change on human health, indicators of vulnerability and preparedness along with accurate surveillance data on climate-sensitive health outcomes are needed. We researched and developed environmental health indicators for inputs into human health vulnerability assessments for climate change and to propose public health preventative actions. Data sources We conducted a review of the scientific literature to identify outcomes and actions that were related to climate change. Data sources included governmental and nongovernmental agencies and the published literature. Data extraction Sources were identified and assessed for completeness, usability, and accuracy. Priority was then given to identifying longitudinal data sets that were applicable at the state and community level. Data synthesis We present a list of surveillance indicators for practitioners and policy makers that include climate-sensitive health outcomes and environmental and vulnerability indicators, as well as mitigation, adaptation, and policy indicators of climate change. Conclusions A review of environmental health indicators for climate change shows that data exist for many of these measures, but more evaluation of their sensitivity and usefulness is needed. Further attention is necessary to increase data quality and availability and to develop new surveillance databases, especially for climate-sensitive morbidity. PMID:20049116

Modelling socio-environmental sensitivities: how public responses to low carbon energy technologies could shape the UK energy system.

PubMed

Moran Jay, Brighid; Howard, David; Hughes, Nick; Whitaker, Jeanette; Anandarajah, Gabrial

2014-01-01

Low carbon energy technologies are not deployed in a social vacuum; there are a variety of complex ways in which people understand and engage with these technologies and the changing energy system overall. However, the role of the public's socio-environmental sensitivities to low carbon energy technologies and their responses to energy deployments does not receive much serious attention in planning decarbonisation pathways to 2050. Resistance to certain resources and technologies based on particular socio-environmental sensitivities would alter the portfolio of options available which could shape how the energy system achieves decarbonisation (the decarbonisation pathway) as well as affecting the cost and achievability of decarbonisation. Thus, this paper presents a series of three modelled scenarios which illustrate the way that a variety of socio-environmental sensitivities could impact the development of the energy system and the decarbonisation pathway. The scenarios represent risk aversion (DREAD) which avoids deployment of potentially unsafe large-scale technology, local protectionism (NIMBY) that constrains systems to their existing spatial footprint, and environmental awareness (ECO) where protection of natural resources is paramount. Very different solutions for all three sets of constraints are identified; some seem slightly implausible (DREAD) and all show increased cost (especially in ECO).

Modelling Socio-Environmental Sensitivities: How Public Responses to Low Carbon Energy Technologies Could Shape the UK Energy System

PubMed Central

Moran Jay, Brighid

2014-01-01

Low carbon energy technologies are not deployed in a social vacuum; there are a variety of complex ways in which people understand and engage with these technologies and the changing energy system overall. However, the role of the public's socio-environmental sensitivities to low carbon energy technologies and their responses to energy deployments does not receive much serious attention in planning decarbonisation pathways to 2050. Resistance to certain resources and technologies based on particular socio-environmental sensitivities would alter the portfolio of options available which could shape how the energy system achieves decarbonisation (the decarbonisation pathway) as well as affecting the cost and achievability of decarbonisation. Thus, this paper presents a series of three modelled scenarios which illustrate the way that a variety of socio-environmental sensitivities could impact the development of the energy system and the decarbonisation pathway. The scenarios represent risk aversion (DREAD) which avoids deployment of potentially unsafe large-scale technology, local protectionism (NIMBY) that constrains systems to their existing spatial footprint, and environmental awareness (ECO) where protection of natural resources is paramount. Very different solutions for all three sets of constraints are identified; some seem slightly implausible (DREAD) and all show increased cost (especially in ECO). PMID:24587735

Differences in Allergic Sensitization by Self-reported Race and Genetic Ancestry

PubMed Central

Yang, James J.; Burchard, Esteban G.; Choudhry, Shweta; Johnson, Christine C.; Ownby, Dennis R.; Favro, David; Chen, Justin; Akana, Matthew; Ha, Connie; Kwok, Pui-Yan; Krajenta, Richard; Havstad, Suzanne L.; Joseph, Christine L.; Seibold, Max A.; Shriver, Mark D.; Williams, L. Keoki

2010-01-01

Background Many allergic conditions occur more frequently in African-American patients when compared with white patients; however it is not known whether this represents genetic predisposition or disparate environmental exposures. Objective To assess the relationship of self-reported race and genetic ancestry to allergic sensitization. Methods We included 601 women enrolled in a population-based cohort study whose self-reported race was African-American or white. Genetic ancestry was estimated using markers that differentiate West African and European ancestry. We assessed the relationship between allergic sensitization (defined as ≥1 allergen-specific IgE result) and both self-reported race and genetic ancestry. Regression models adjusted for socio-demographic variables, environmental exposures, and location of residence. Results The average proportion of West African ancestry in African-American participants was 0.69, whereas the mean proportion of European ancestry in white participants was 0.79. Self-reported African-American race was associated with allergic sensitization when compared with those who reported being white (adjusted odds ratio [aOR] 2.19; 95% confidence interval [CI] 1.22 – 3.93) even after adjusting for other variables. Genetic ancestry was not significantly associated with allergic sensitization after accounting for location of residence (aOR 2.09 for urban vs. suburban residence, 95% CI 1.32 −3.31). Conclusion Self-reported race and location of residence appeared to be more important predictors of allergic sensitization when compared with genetic ancestry, suggesting that the disparity in allergic sensitization by race may be primarily due to environmental factors rather than genetic differences. Clinical Implications These data suggest that efforts to eliminate disparities in allergic sensitization should focus on contributing environmental factors. PMID:19014772

A Study of Predictors of Environmental Behaviour using U.S. Samples.

ERIC Educational Resources Information Center

Sia, Archibald P.; And Others

1986-01-01

Reports on a study done with the intentions of determining the relative contribution of eight variables in predicting environmental behavior. Concluded that the major predictors were skill in using environmental action strategies, level of environmental sensitivity, and percieved knowledge of environmental action strategies. (TW)

Sensitive and selective culture medium for detection of environmental Clostridium difficile isolates without requirement for anaerobic culture conditions.

PubMed

Cadnum, Jennifer L; Hurless, Kelly N; Deshpande, Abhishek; Nerandzic, Michelle M; Kundrapu, Sirisha; Donskey, Curtis J

2014-09-01

Effective and easy-to-use methods for detecting Clostridium difficile spore contamination would be useful for identifying environmental reservoirs and monitoring the effectiveness of room disinfection. Culture-based detection methods are sensitive for detecting C. difficile, but their utility is limited due to the requirement of anaerobic culture conditions and microbiological expertise. We developed a low-cost selective broth medium containing thioglycolic acid and l-cystine, termed C. difficile brucella broth with thioglycolic acid and l-cystine (CDBB-TC), for the detection of C. difficile from environmental specimens under aerobic culture conditions. The sensitivity and specificity of CDBB-TC (under aerobic culture conditions) were compared to those of CDBB (under anaerobic culture conditions) for the recovery of C. difficile from swabs collected from hospital room surfaces. CDBB-TC was significantly more sensitive than CDBB for recovering environmental C. difficile (36/41 [88%] versus 21/41 [51%], respectively; P = 0.006). C. difficile latex agglutination, an enzyme immunoassay for toxins A and B or glutamate dehydrogenase, and a PCR for toxin B genes were all effective as confirmatory tests. For 477 total environmental cultures, the specificity of CDBB-TC versus that of CDBB based upon false-positive yellow-color development of the medium without recovery of C. difficile was 100% (0 false-positive results) versus 96% (18 false-positive results), respectively. False-positive cultures for CDBB were attributable to the growth of anaerobic non-C. difficile organisms that did not grow in CDBB-TC. Our results suggest that CDBB-TC provides a sensitive and selective medium for the recovery of C. difficile organisms from environmental samples, without the need for anaerobic culture conditions. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

RESEARCH ON ENVIRONMENTAL HEALTH INTERVENTIONS: ETHICAL PROBLEMS AND SOLUTIONS

PubMed Central

RESNIK, DAVID B.; ZELDIN, DARRYL C.; SHARP, RICHARD R.

2014-01-01

This article reviews a variety of ethical issues one must consider when conducting research on environmental health interventions on human subjects. The paper uses the Kennedy Krieger Institute lead abatement study as well as a hypothetical asthma study to discuss questions concerning benefits and risks, risk minimization, safety monitoring, the duty to warn, the duty to report, the use of control groups, informed consent, equitable subject selection, privacy, conflicts of interest, and community consultation. Research on environmental health interventions can make an important contribution to our understanding of human health and disease prevention, provided it is conducted in a manner that meets prevailing scientific, ethical, and legal standards for research on human subjects. PMID:16220621

Environmental aspects of large-scale wind-power systems in the UK

NASA Astrophysics Data System (ADS)

Robson, A.

1983-12-01

Environmental issues relating to the introduction of large, MW-scale wind turbines at land-based sites in the U.K. are discussed. Areas of interest include noise, television interference, hazards to bird life and visual effects. A number of areas of uncertainty are identified, but enough is known from experience elsewhere in the world to enable the first U.K. machines to be introduced in a safe and environmentally acceptable manner. Research currently under way will serve to establish siting criteria more clearly, and could significantly increase the potential wind-energy resource. Certain studies of the comparative risk of energy systems are shown to be overpessimistic for U.K. wind turbines.

Grid sensitivity capability for large scale structures

NASA Technical Reports Server (NTRS)

Nagendra, Gopal K.; Wallerstein, David V.

1989-01-01

The considerations and the resultant approach used to implement design sensitivity capability for grids into a large scale, general purpose finite element system (MSC/NASTRAN) are presented. The design variables are grid perturbations with a rather general linking capability. Moreover, shape and sizing variables may be linked together. The design is general enough to facilitate geometric modeling techniques for generating design variable linking schemes in an easy and straightforward manner. Test cases have been run and validated by comparison with the overall finite difference method. The linking of a design sensitivity capability for shape variables in MSC/NASTRAN with an optimizer would give designers a powerful, automated tool to carry out practical optimization design of real life, complicated structures.

Land quality, sustainable development and environmental degradation in agricultural districts: A computational approach based on entropy indexes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zambon, Ilaria, E-mail: ilaria.zambon@unitus.it; Colantoni, Andrea; Carlucci, Margherita

Land Degradation (LD) in socio-environmental systems negatively impacts sustainable development paths. This study proposes a framework to LD evaluation based on indicators of diversification in the spatial distribution of sensitive land. We hypothesize that conditions for spatial heterogeneity in a composite index of land sensitivity are more frequently associated to areas prone to LD than spatial homogeneity. Spatial heterogeneity is supposed to be associated with degraded areas that act as hotspots for future degradation processes. A diachronic analysis (1960–2010) was performed at the Italian agricultural district scale to identify environmental factors associated with spatial heterogeneity in the degree of landmore » sensitivity to degradation based on the Environmentally Sensitive Area Index (ESAI). In 1960, diversification in the level of land sensitivity measured using two common indexes of entropy (Shannon's diversity and Pielou's evenness) increased significantly with the ESAI, indicating a high level of land sensitivity to degradation. In 2010, surface area classified as “critical” to LD was the highest in districts with diversification in the spatial distribution of ESAI values, confirming the hypothesis formulated above. Entropy indexes, based on observed alignment with the concept of LD, constitute a valuable base to inform mitigation strategies against desertification. - Highlights: • Spatial heterogeneity is supposed to be associated with degraded areas. • Entropy indexes can inform mitigation strategies against desertification. • Assessing spatial diversification in the degree of land sensitivity to degradation. • Mediterranean rural areas have an evident diversity in agricultural systems. • A diachronic analysis carried out at the Italian agricultural district scale.« less

DEVELOPMENT OF MOLECULAR MARKERS OF RESPONSE TO ASSESS THE SENSITIVITY OF CHILDREN TO ENVIRONMENTAL CHEMICALS

EPA Science Inventory

Development of Molecular Markers of Response to Assess the Sensitivity of Children to Environmental Chemicals

J.Allen, C. Blackman, M. Blaze, D. Delker, D. DeMarini, C. Doerr, R. Grindstaff, S.
Hester, C. Jones, A. Kligerman, G. Knapp, M. Kohan, C. Nelson, R. Owen, J. P...

PROCEEDINGS OF THE INTERNATIONAL WORKSHOP ON UNCERTAINTY, SENSITIVITY, AND PARAMETER ESTIMATION FOR MULTIMEDIA ENVIRONMENTAL MODELING. EPA/600/R-04/117, NUREG/CP-0187, ERDC SR-04-2.

EPA Science Inventory

An International Workshop on Uncertainty, Sensitivity, and Parameter Estimation for Multimedia Environmental Modeling was held August 1921, 2003, at the U.S. Nuclear Regulatory Commission Headquarters in Rockville, Maryland, USA. The workshop was organized and convened by the Fe...

Synthetic Space Vector Modulation

DTIC Science & Technology

2013-06-01

especially batteries without fancy controls. Inherently, DC machine commutation is environmentally sensitive and maintenance intensive at well as...reliable DC power supplies especially batteries without fancy controls. Inherently, DC machine commutation is environmentally sensitive and maintenance...Drives and Energy Systems, New Delhi, India , 20-23 December, 2010. [12] PIC18F2331/2431/4331/4431 datasheet DS39616B, Microchip Technology Inc

A conceptualisation framework for building consensus on environmental sensitivity.

PubMed

González Del Campo, Ainhoa

2017-09-15

Examination of the intrinsic attributes of a system that render it more or less sensitive to potential stressors provides further insight into the baseline environment. In impact assessment, sensitivity of environmental receptors can be conceptualised on the basis of their: a) quality status according to statutory indicators and associated thresholds or targets; b) statutory protection; or c) inherent risk. Where none of these considerations are pertinent, subjective value judgments can be applied to determine sensitivity. This pragmatic conceptual framework formed the basis of a stakeholder consultation process for harmonising degrees of sensitivity of a number of environmental criteria. Harmonisation was sought to facilitate their comparative and combined analysis. Overall, full or wide agreement was reached on relative sensitivity values for the large majority of the reviewed criteria. Consensus was easier to reach on some themes (e.g. biodiversity, water and cultural heritage) than others (e.g. population and soils). As anticipated, existing statutory measures shaped the outcomes but, ultimately, knowledge-based values prevailed. The agreed relative sensitivities warrant extensive consultation but the conceptual framework provides a basis for increasing stakeholder consensus and objectivity of baseline assessments. This, in turn, can contribute to improving the evidence-base for characterising the significance of potential impacts. Copyright © 2017 Elsevier Ltd. All rights reserved.

Hippocampal volume and sensitivity to maternal aggressive behavior: a prospective study of adolescent depressive symptoms.

PubMed

Whittle, Sarah; Yap, Marie B H; Sheeber, Lisa; Dudgeon, Paul; Yücel, Murat; Pantelis, Christos; Simmons, Julian G; Allen, Nicholas B

2011-02-01

It has been suggested that biological factors confer increased sensitivity to environmental influences on depressive symptoms during adolescence, a crucial time for the onset of depressive disorders. Given the critical role of the hippocampus in sensitivity to stress and processing of contextual aspects of the environment, investigation of its role in determining sensitivity to environmental context seems warranted. This study prospectively examined hippocampal volume as a measure of sensitivity to the influence of aggressive maternal behavior on change in depressive symptoms from early to midadolescence. The interaction between aggressive maternal behavior and hippocampal volume was found to predict change in depressive symptoms. Significant sex differences also emerged, whereby only for girls were larger bilateral hippocampal volumes more sensitive to the effects of maternal aggressive behavior, particularly with respect to experiencing the protective effects of low levels of maternal aggressiveness. These findings help elucidate the complex relationships between brain structure, environmental factors such as maternal parenting style, and sensitivity to (i.e., risk for, and protection from) the emergence of depression during this life stage. Given that family context risk factors are modifiable, our findings suggest the potential utility of targeted parenting interventions for the prevention and treatment of adolescent depressive disorder.

Sensitivity of Four Cyanobacterial Isolates from Tropical Freshwaters to Environmentally Realistic Concentrations of Cr(6+), Cd(2+) and Zn(2.).

PubMed

Munagamage, Thilini; Rathnayake, I V N; Pathiratne, A; Megharaj, Mallavarapu

2016-06-01

Sensitivity of four tropical cyanobacteria viz. Coelosphaerium sp., Synechococcus sp., Oscillatoria sp. and Chroococcus sp. to environmentally relevant concentrations of Cr(6+), Cd(2+) and Zn(2+)was assessed based on fluorescence change as a proxy for growth reduction. At 24 h exposure, the growth reduction inthe cyanobacteria followed the order: Zn(2+) < Cr(6+) ≤ Cd(2+). Of the four cyanobacteria, Synechococcus was the most sensitive for Cr(6+), where as Chroococcus was the most sensitive for Cd(2+)and Zn(2+). Sensitivity was gradually decreased by 96 h implying the acquisition of tolerance by cyanobacteria to heavy metal ions with prolonged exposure.

Genetic influence on contrast sensitivity in middle-aged male twins.

PubMed

Cronin-Golomb, Alice; Panizzon, Matthew S; Lyons, Michael J; Franz, Carol E; Grant, Michael D; Jacobson, Kristen C; Eisen, Seth A; Laudate, Thomas M; Kremen, William S

2007-07-01

Contrast sensitivity is strongly associated with daily functioning among older adults, but the genetic and environmental contributions to this ability are unknown. Using the classical twin method, we addressed this issue by examining contrast sensitivity at five spatial frequencies (1.5-18 cycles per degree) in 718 middle-aged male twins from the Vietnam Era Twin Study of Aging (VETSA). Heritability estimates were modest (14-38%), whereas individual-specific environmental influences accounted for 62-86% of the variance. Identifying the types of individual-specific events that impact contrast sensitivity may suggest interventions to modulate this ability and thereby improve overall quality of life as adults age.

Addressing Curse of Dimensionality in Sensitivity Analysis: How Can We Handle High-Dimensional Problems?

NASA Astrophysics Data System (ADS)

Safaei, S.; Haghnegahdar, A.; Razavi, S.

2016-12-01

Complex environmental models are now the primary tool to inform decision makers for the current or future management of environmental resources under the climate and environmental changes. These complex models often contain a large number of parameters that need to be determined by a computationally intensive calibration procedure. Sensitivity analysis (SA) is a very useful tool that not only allows for understanding the model behavior, but also helps in reducing the number of calibration parameters by identifying unimportant ones. The issue is that most global sensitivity techniques are highly computationally demanding themselves for generating robust and stable sensitivity metrics over the entire model response surface. Recently, a novel global sensitivity analysis method, Variogram Analysis of Response Surfaces (VARS), is introduced that can efficiently provide a comprehensive assessment of global sensitivity using the Variogram concept. In this work, we aim to evaluate the effectiveness of this highly efficient GSA method in saving computational burden, when applied to systems with extra-large number of input factors ( 100). We use a test function and a hydrological modelling case study to demonstrate the capability of VARS method in reducing problem dimensionality by identifying important vs unimportant input factors.

Preparing the Information Professional: An Agenda for the Future. Contributions in Librarianship and Information Science, Number 93.

ERIC Educational Resources Information Center

Rehman, Sajjad ur

Redesigning information education in response to the market dynamic requires clear articulation of the expectations of employers, identification of competencies for professionals, and appreciation of environmental, institutional, and situational contexts. This book responds to these needs in a systematic and scientific manner by describing methods…

Toward the Greening of Our Minds: A New Special Topics Course

ERIC Educational Resources Information Center

Marteel-Parrish, Anne E.

2007-01-01

A new special-topics course on green chemistry would help students to critically evaluate policy decisions in an environmentally conscientious manner. The actively acquired knowledge would allow students to spread the word about green chemistry in the long term to the world, where they would pursue their future goals of life.

77 FR 22676 - Revisions to the Arizona State Implementation Plan, Pinal County Air Quality Control District

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-17

... the Arizona State Implementation Plan, Pinal County Air Quality Control District AGENCY: Environmental... disapproval of a revision to the Pinal County Air Quality Control District portion of the Arizona State... the Control Officer to determine whether the manner of control of fugitive emissions is satisfactory...

40 CFR 721.6140 - Dialkyldithiophosphoric acid, aliphatic amine salt.

Code of Federal Regulations, 2010 CFR

2010-07-01

... methods for protecting against such risk, into an MSDS as described in § 721.72(c) within 90 days from the..., aliphatic amine salt. 721.6140 Section 721.6140 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... manner or method of manufacture, import, or processing associated with any use of this substance without...

Sustainable Biomass Resource Development and Use | Energy Analysis | NREL

Science.gov Websites

Sustainable Biomass Resource Development and Use Sustainable Biomass Resource Development and Use A sustainability analysis includes biomass resource use and impact assessment. This analysis examines how we can use existing resources in a sustainable manner. It also examines the environmental and socio-economic

40 CFR 146.15 - Class I municipal disposal well alternative authorization in certain parts of Florida.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM... ground water monitoring data generated pursuant to regulatory requirements governing operation of Class I...-600.420(1)(d), and using high-level disinfection in a manner that is no less stringent than the...

40 CFR 146.15 - Class I municipal disposal well alternative authorization in certain parts of Florida.

Code of Federal Regulations, 2012 CFR

2012-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM... ground water monitoring data generated pursuant to regulatory requirements governing operation of Class I...-600.420(1)(d), and using high-level disinfection in a manner that is no less stringent than the...

40 CFR 146.15 - Class I municipal disposal well alternative authorization in certain parts of Florida.

Code of Federal Regulations, 2011 CFR

2011-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM... ground water monitoring data generated pursuant to regulatory requirements governing operation of Class I...-600.420(1)(d), and using high-level disinfection in a manner that is no less stringent than the...

40 CFR 146.15 - Class I municipal disposal well alternative authorization in certain parts of Florida.

Code of Federal Regulations, 2013 CFR

2013-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM... ground water monitoring data generated pursuant to regulatory requirements governing operation of Class I...-600.420(1)(d), and using high-level disinfection in a manner that is no less stringent than the...

40 CFR 146.15 - Class I municipal disposal well alternative authorization in certain parts of Florida.

Code of Federal Regulations, 2014 CFR

2014-07-01

... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM... ground water monitoring data generated pursuant to regulatory requirements governing operation of Class I...-600.420(1)(d), and using high-level disinfection in a manner that is no less stringent than the...

Moving to a Decision Point in Sustainability Analysis, chapter 4 in book entitled: Assessing and Measuring Environmental Impact and Sustainability

EPA Science Inventory

Abstract A measurable “sustainability footprint” can be constructed from the chosen indicators to assess relative sustainability. We show in a step by step manner with three case studies how the sustainability footprint based on Euclidean distance of a system from a ...

Student Preparation Workbook for the Multnomah Outdoor School. Revised Edition.

ERIC Educational Resources Information Center

Bohm, Rudy; Cole, Wally

Designed for sixth grade students to help them prepare for the Multnomah County (Oregon) Outdoor School experience, the workbook provides fundamental information about soil, water, plant, and animal resources. The workbook begins with an introduction to environmental manners (rules for working in the woods). A section devoted to each resource area…

Cross-species integration of human health and ecological endpoints into risk assessment using the Aggregate Exposure Pathway and Adverse Outcome Pathway frameworks

EPA Science Inventory

Exposure to environmental contaminants can influence both human health and ecological endpoints. Chemical risk assessments combine exposure and toxicity data to estimate the likelihood of adverse outcomes for these endpoints, but are rarely conducted in a manner that integrates ...

78 FR 59019 - Product Cancellation Order for Certain Pesticide Registrations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-25

... requested cancellations. Any distribution, sale, or use of the products subject to this cancellation order... distribution, sale, or use of existing stocks of the products identified in Table 1 of Unit II. in a manner... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2010-0014; FRL-9400-7] Product Cancellation Order for...

Chemoselective formation of unsymmetrically substituted ethers from catalytic reductive coupling of aldehydes and ketones with alcohols in aqueous solution.

PubMed

Kalutharage, Nishantha; Yi, Chae S

2015-04-03

A well-defined cationic Ru-H complex catalyzes reductive etherification of aldehydes and ketones with alcohols. The catalytic method employs environmentally benign water as the solvent and cheaply available molecular hydrogen as the reducing agent to afford unsymmetrical ethers in a highly chemoselective manner.

Simulated International Politics: Classroom Exercises.

ERIC Educational Resources Information Center

Jackson, Robert M.; And Others

The manual consists of six easy to use simulation exercises for foreign relation classes at the secondary level. The games are designed to teach decision making skills, to sensitize students to the manner in which Americans have come to view the world, to help students understand the need to manage problems before they become too severe, and to…

The Hook.

ERIC Educational Resources Information Center

Whiteker, Clarice

1995-01-01

Describes a teacher's relationship with a 15-year-old student whose father's mental illness and abusive manner led the student to try to commit suicide. Raises questions about what a teacher can do for such a student and suggests that reading can be one way that teachers and students can be led to talk about sensitive topics. (TB)

A mixture of Iprodione and Vinclozolin delays the onset of puberty in the male rat in a cumulative manner.

EPA Science Inventory

Vinclozolin and iprodione are dicarboximide fungicides that display anti-androgenic effects in the male rat, which suggests co-exposure to these fungicides would lead to cumulative effects on androgen-sensitive endpoints. In order to test for cumulative effects by iprodione and v...

40 CFR 35.3580 - Environmental review requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... consequences on the existing environment, the future environment, and individual sensitive environmental issues... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Environmental review requirements. 35.3580 Section 35.3580 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL...

Ortho-Babinet polarization-interrogating filter: an interferometric approach to polarization measurement.

PubMed

Van Delden, Jay S

2003-07-15

A novel, interferometric, polarization-interrogating filter assembly and method for the simultaneous measurement of all four Stokes parameters across a partially polarized irradiance image in a no-moving-parts, instantaneous, highly sensitive manner is described. In the reported embodiment of the filter, two spatially varying linear retarders and a linear polarizer comprise an ortho-Babinet, polarization-interrogating (OBPI) filter. The OBPI filter uniquely encodes the incident ensemble of electromagnetic wave fronts comprising a partially polarized irradiance image in a controlled, deterministic, spatially varying manner to map the complete state of polarization across the image to local variations in a superposed interference pattern. Experimental interferograms are reported along with a numerical simulation of the method.

Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels.

PubMed

Suga, S; Wu, J; Ogawa, Y; Takeo, T; Kanno, T; Wakui, M

2001-01-01

Phorbol 12-myristate 13-acetate (PMA) is often used as an activating phorbol ester of protein kinase C (PKC) to investigate the roles of the kinase in cellular functions. Accumulating lines of evidence indicate that in addition to activating PKC, PMA also produces some regulatory effects in a PKC-independent manner. In this study, we investigated the non-PKC effects of PMA on electrical excitability of rat pancreatic beta-cells by using patch-clamp techniques. In current-clamp recording, PMA (80 nM) reversibly inhibited 15 mM glucose-induced action potential spikes superimposed on a slow membrane depolarization and this inhibition can not be prevented by pre-treatment of the cell with a specific PKC inhibitor, bisindolylmaleimide (BIM, 1 microM). In the presence of a subthreshold concentration (5.5 mM) of glucose, PMA hyperpolarized beta-cells in a concentration-dependent manner (0.8-240 nM), even in the presence of BIM. Based on cell-attached single channel recordings, PMA increased ATP-sensitive K+ channel (KATP) activity. Based on inside-out patch-clamp recordings, PMA had little effect on KATP activity if no ATP was in the bath, while PMA restored KATP activity that was suppressed by 10 microM ATP in the bath. In voltage-clamp recording, PMA enhanced tolbutamide-sensitive membrane currents elicited by repetitive ramp pulses from -90 to -50 mV in a concentration-dependent manner, and this potentiation could not be prevented by pre-treatment of cell with BIM. 4alpha-phorbol 12,13-didecanoate (4alpha-PDD), a non-PKC-activating phorbol ester, mimicked the effect of PMA on both current-clamp and voltage-clamp recording configurations. With either 5.5 or 16.6 mM glucose in the extracellular solution, PMA (80 nM) increased insulin secretion from rat islets. However, in islets pretreated with BIM (1 microM), PMA did not increase, but rather reduced insulin secretion. In rat pancreatic beta-cells, PMA modulates insulin secretion through a mixed mechanism: increases insulin secretion by activation of PKC, and meanwhile decrease insulin secretion by impairing beta-cell excitability in a PKC-independent manner. The enhancement of KATP activity by reducing sensitivity of KATP to ATP seems to underlie the PMA-induced impairment of beta-cells electrical excitation in response to glucose stimulation.

Identifying significant environmental features using feature recognition.

DOT National Transportation Integrated Search

2015-10-01

The Department of Environmental Analysis at the Kentucky Transportation Cabinet has expressed an interest in feature-recognition capability because it may help analysts identify environmentally sensitive features in the landscape, : including those r...

Sulfur and nitrogen binary doped carbon dots derived from ammonium thiocyanate for selective probing doxycycline in living cells and multicolor cell imaging.

PubMed

Xue, Mingyue; Zhang, Liangliang; Zhan, Zhihua; Zou, Mengbing; Huang, Yong; Zhao, Shulin

2016-04-01

A novel sulfur and nitrogen binary doped carbon dots (S,N-CDs) was synthesized by one-step manner through the hydrothermal treatment of citric acid (CA) and ammonium thiocyanate, and the procedures for biomedical applications, including probing doxycycline in living cells and multicolor cell imaging were developed. The obtained S,N-CDs are stable in aqueous solution, possess a very high quantum yield (QY, 74.15%) and good photostability. The fluorescence of S,N-CDs can be specifically quenched by doxycycline, providing a convenient turn-off assay of doxycycline. This assay shows a wide linear detection range from 0.08 to 60 μM with a low detection limit of 20 nM. The present method also displays a good selectivity. More importantly, the S,N-CDs have an excellent biocompatibility and low cytotoxicity, allowing the multicolor cell imaging and doxycycline detection in living cells. Consequently, the developed doxycycline methods is facile, low-cost, biocompatible, sensitive and selective, which may hold the potential applications in the fields of food safety and environmental monitoring, as well as cancer therapy and related mechanism research. Copyright © 2015 Elsevier B.V. All rights reserved.

Single-Cell Mass Spectrometry Reveals Changes in Lipid and Metabolite Expression in RAW 264.7 Cells upon Lipopolysaccharide Stimulation

NASA Astrophysics Data System (ADS)

Yang, Bo; Patterson, Nathan Heath; Tsui, Tina; Caprioli, Richard M.; Norris, Jeremy L.

2018-05-01

It has been widely recognized that individual cells that exist within a large population of cells, even if they are genetically identical, can have divergent molecular makeups resulting from a variety of factors, including local environmental factors and stochastic processes within each cell. Presently, numerous approaches have been described that permit the resolution of these single-cell expression differences for RNA and protein; however, relatively few techniques exist for the study of lipids and metabolites in this manner. This study presents a methodology for the analysis of metabolite and lipid expression at the level of a single cell through the use of imaging mass spectrometry on a high-performance Fourier transform ion cyclotron resonance mass spectrometer. This report provides a detailed description of the overall experimental approach, including sample preparation as well as the data acquisition and analysis strategy for single cells. Applying this approach to the study of cultured RAW264.7 cells, we demonstrate that this method can be used to study the variation in molecular expression with cell populations and is sensitive to alterations in that expression that occurs upon lipopolysaccharide stimulation. [Figure not available: see fulltext.

Evaluation of Indoor Air Quality Screening Strategies: A Step-Wise Approach for IAQ Screening.

PubMed

Wong, Ling-Tim; Mui, Kwok-Wai; Tsang, Tsz-Wun

2016-12-14

Conducting a full indoor air quality (IAQ) assessment in air-conditioned offices requires large-scale material and manpower resources. However, an IAQ index can be adopted as a handy screening tool to identify any premises (with poor IAQ) that need more comprehensive IAQ assessments to prioritize IAQ improvements. This study proposes a step-wise IAQ screening protocol to facilitate its cost-effective management among building owners and managers. The effectiveness of three IAQ indices, namely θ₁ (with one parameter: CO₂), θ₂ (with two parameters: CO₂ and respirable suspended particulates, RSP) and θ₃ (with three parameters: CO₂, RSP, and total volatile organic compounds, TVOC) are evaluated. Compared in a pairwise manner with respect to the minimum satisfaction levels as stated in the IAQ Certification Scheme by the Hong Kong Environmental Protection Department, the results show that a screening test with more surrogate IAQ parameters is good at identifying both lower and higher risk groups for unsatisfactory IAQ, and thus offers higher resolution. Through the sensitivity and specificity for identifying IAQ problems, the effectiveness of alternative IAQ screening methods with different monitoring parameters is also reported.

Risk Communication Emergency Response Preparedness: Contextual Assessment of the Protective Action Decision Model.

PubMed

Heath, Robert L; Lee, Jaesub; Palenchar, Michael J; Lemon, Laura L

2018-02-01

Studies are continuously performed to improve risk communication campaign designs to better prepare residents to act in the safest manner during an emergency. To that end, this article investigates the predictive ability of the protective action decision model (PADM), which links environmental and social cues, predecision processes (attention, exposure, and comprehension), and risk decision perceptions (threat, alternative protective actions, and stakeholder norms) with protective action decision making. This current quasi-longitudinal study of residents (N = 400 for each year) in a high-risk (chemical release) petrochemical manufacturing community investigated whether PADM core risk perceptions predict protective action decision making. Telephone survey data collected at four intervals (1995, 1998, 2002, 2012) reveal that perceptions of protective actions and stakeholder norms, but not of threat, currently predict protective action decision making (intention to shelter in place). Of significance, rather than threat perceptions, perception of Wally Wise Guy (a spokes-character who advocates shelter in place) correlates with perceptions of protective action, stakeholder norms, and protective action decision making. Wally's response-efficacy advice predicts residents' behavioral intentions to shelter in place, thereby offering contextually sensitive support and refinement for PADM. © 2017 Society for Risk Analysis.

The Phycomyces madA gene encodes a blue-light photoreceptor for phototropism and other light responses.

PubMed

Idnurm, Alexander; Rodríguez-Romero, Julio; Corrochano, Luis M; Sanz, Catalina; Iturriaga, Enrique A; Eslava, Arturo P; Heitman, Joseph

2006-03-21

Phycomyces blakesleeanus is a filamentous zygomycete fungus that produces striking elongated single cells that extend up to 10 cm into the air, with each such sporangiophore supporting a sphere containing the spores for dispersal. This organism has served as a model for the detection of environmental signals as diverse as light, chemicals, touch, wind, gravity, and adjacent objects. In particular, sporangiophore growth is regulated by light, and it exhibits phototropism by bending toward near-UV and blue wavelengths and away from far-UV wavelengths in a manner that is physiologically similar to plant phototropic responses. The Phycomyces madA mutants were first isolated more than 40 years ago, and they exhibit reduced sensitivity to light. Here, we identify two (duplicated) homologs in the White Collar 1 family of blue-light photoreceptors in Phycomyces. We describe that the madA mutant strains contain point mutations in one of these genes and that these mutations cosegregate with a defect in phototropism after genetic crosses. Thus, the phototropic responses of fungi through madA and plants through phototropin rely on diverse proteins; however, these proteins share a conserved flavin-binding domain for photon detection.

The Phycomyces madA gene encodes a blue-light photoreceptor for phototropism and other light responses

PubMed Central

Idnurm, Alexander; Rodríguez-Romero, Julio; Corrochano, Luis M.; Sanz, Catalina; Iturriaga, Enrique A.; Eslava, Arturo P.; Heitman, Joseph

2006-01-01

Phycomyces blakesleeanus is a filamentous zygomycete fungus that produces striking elongated single cells that extend up to 10 cm into the air, with each such sporangiophore supporting a sphere containing the spores for dispersal. This organism has served as a model for the detection of environmental signals as diverse as light, chemicals, touch, wind, gravity, and adjacent objects. In particular, sporangiophore growth is regulated by light, and it exhibits phototropism by bending toward near-UV and blue wavelengths and away from far-UV wavelengths in a manner that is physiologically similar to plant phototropic responses. The Phycomyces madA mutants were first isolated more than 40 years ago, and they exhibit reduced sensitivity to light. Here, we identify two (duplicated) homologs in the White Collar 1 family of blue-light photoreceptors in Phycomyces. We describe that the madA mutant strains contain point mutations in one of these genes and that these mutations cosegregate with a defect in phototropism after genetic crosses. Thus, the phototropic responses of fungi through madA and plants through phototropin rely on diverse proteins; however, these proteins share a conserved flavin-binding domain for photon detection. PMID:16537433

Single-Cell Mass Spectrometry Reveals Changes in Lipid and Metabolite Expression in RAW 264.7 Cells upon Lipopolysaccharide Stimulation

NASA Astrophysics Data System (ADS)

Yang, Bo; Patterson, Nathan Heath; Tsui, Tina; Caprioli, Richard M.; Norris, Jeremy L.

2018-03-01

It has been widely recognized that individual cells that exist within a large population of cells, even if they are genetically identical, can have divergent molecular makeups resulting from a variety of factors, including local environmental factors and stochastic processes within each cell. Presently, numerous approaches have been described that permit the resolution of these single-cell expression differences for RNA and protein; however, relatively few techniques exist for the study of lipids and metabolites in this manner. This study presents a methodology for the analysis of metabolite and lipid expression at the level of a single cell through the use of imaging mass spectrometry on a high-performance Fourier transform ion cyclotron resonance mass spectrometer. This report provides a detailed description of the overall experimental approach, including sample preparation as well as the data acquisition and analysis strategy for single cells. Applying this approach to the study of cultured RAW264.7 cells, we demonstrate that this method can be used to study the variation in molecular expression with cell populations and is sensitive to alterations in that expression that occurs upon lipopolysaccharide stimulation. [Figure not available: see fulltext.

Sensitivity of erythemal UV/global irradiance ratios to atmospheric parameters: application for estimating erythemal radiation at four sites in Thailand

NASA Astrophysics Data System (ADS)

Buntoung, Sumaman; Janjai, Serm; Nunez, Manuel; Choosri, Pranomkorn; Pratummasoot, Noppamas; Chiwpreecha, Kulanist

2014-11-01

Factors affecting the ratio of erythemal UV (UVER) to broadband (G) irradiance were investigated in this study. Data from four solar monitoring sites in Thailand, namely Chiang Mai, Ubon Ratchathani, Nakhon Pathom and Songkhla were used to investigate the UVER/G ratio in response to geometric and atmospheric parameters. These comprised solar zenith angle, aerosol load, total ozone column, precipitable water and clearness index. A modeling scheme was developed to isolate and examine the effect of each individual environmental parameter on the ratio. Results showed that all parameters with the exception of solar zenith angle and clearness index influenced the ratios in a linear manner. These results were also used to develop a semi-empirical model for estimating hourly erythemal UV irradiance. Data from 2009 to 2010 were used to construct the ratio model while validation was performed using erythemal UV irradiance at the above four sites in 2011. The validation results showed reasonable agreement with a root mean square difference of 13.5% and mean bias difference of - 0.5%, under all sky conditions and 10.9% and - 0.3%, respectively, under cloudless conditions.

Evaluation of Indoor Air Quality Screening Strategies: A Step-Wise Approach for IAQ Screening

PubMed Central

Wong, Ling-tim; Mui, Kwok-wai; Tsang, Tsz-wun

2016-01-01

Conducting a full indoor air quality (IAQ) assessment in air-conditioned offices requires large-scale material and manpower resources. However, an IAQ index can be adopted as a handy screening tool to identify any premises (with poor IAQ) that need more comprehensive IAQ assessments to prioritize IAQ improvements. This study proposes a step-wise IAQ screening protocol to facilitate its cost-effective management among building owners and managers. The effectiveness of three IAQ indices, namely θ1 (with one parameter: CO2), θ2 (with two parameters: CO2 and respirable suspended particulates, RSP) and θ3 (with three parameters: CO2, RSP, and total volatile organic compounds, TVOC) are evaluated. Compared in a pairwise manner with respect to the minimum satisfaction levels as stated in the IAQ Certification Scheme by the Hong Kong Environmental Protection Department, the results show that a screening test with more surrogate IAQ parameters is good at identifying both lower and higher risk groups for unsatisfactory IAQ, and thus offers higher resolution. Through the sensitivity and specificity for identifying IAQ problems, the effectiveness of alternative IAQ screening methods with different monitoring parameters is also reported. PMID:27983667

A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679.

PubMed

Gosset, James R; Beaumont, Kevin; Matsuura, Tomomi; Winchester, Wendy; Attkins, Neil; Glatt, Sophie; Lightbown, Ian; Ulrich, Kristina; Roberts, Sonia; Harris, Jolie; Mesic, Emir; van Steeg, Tamara; Hijdra, Diana; van der Graaf, Piet H

2017-11-15

PF-05105679 is a moderately potent TRPM8 blocker which has been evaluated for the treatment of cold pain sensitivity. The TRPM8 channel is responsible for the sensation of cold environmental temperatures and has been implicated in regulation of core body temperature. Consequently, blockade of TRPM8 has been suggested to result in lowering of core body temperature. As part of the progression to human studies, the effect of PF-05105679 on core body temperature has been investigated in animals. Safety pharmacology studies showed that PF-05105679 reduced core body temperature in a manner that was inversely related to body weight of the species tested (greater exposure to PF-05105679 was required to lower temperature by 1°C in higher species). Based on an allometric (body weight) relationship, it was hypothesized that PF-05105679 would not lower core body temperature in humans at exposures that could exhibit pharmacological effects on cold pain sensation. On administration to humans, PF-05105679 was indeed effective at reversing the cold pain sensation associated with the cold pressor test in the absence of effects on core body temperature. Copyright © 2017 Elsevier B.V. All rights reserved.

Organic and Inorganic Dyes in Polyelectrolyte Multilayer Films

PubMed Central

Ball, Vincent

2012-01-01

Polyelectrolyte multilayer films are a versatile functionalization method of surfaces and rely on the alternated adsorption of oppositely charged species. Among such species, charged dyes can also be alternated with oppositely charged polymers, which is challenging from a fundamental point of view, because polyelectrolytes require a minimal number of charges, whereas even monovalent dyes can be incorporated during the alternated adsorption process. We will not only focus on organic dyes but also on their inorganic counterparts and on metal complexes. Such films offer plenty of possible applications in dye sensitized solar cells. In addition, dyes are massively used in the textile industry and in histology to stain textile fibers or tissues. However, the excess of non bound dyes poses serious environmental problems. It is hence of the highest interest to design materials able to adsorb such dyes in an almost irreversible manner. Polyelectrolyte multilayer films, owing to their ion exchange behavior can be useful for such a task allowing for impressive overconcentration of dyes with respect to the dye in solution. The actual state of knowledge of the interactions between charged dyes and adsorbed polyelectrolytes is the focus of this review article.

Metabolic gene regulation in a dynamically changing environment.

PubMed

Bennett, Matthew R; Pang, Wyming Lee; Ostroff, Natalie A; Baumgartner, Bridget L; Nayak, Sujata; Tsimring, Lev S; Hasty, Jeff

2008-08-28

Natural selection dictates that cells constantly adapt to dynamically changing environments in a context-dependent manner. Gene-regulatory networks often mediate the cellular response to perturbation, and an understanding of cellular adaptation will require experimental approaches aimed at subjecting cells to a dynamic environment that mimics their natural habitat. Here we monitor the response of Saccharomyces cerevisiae metabolic gene regulation to periodic changes in the external carbon source by using a microfluidic platform that allows precise, dynamic control over environmental conditions. We show that the metabolic system acts as a low-pass filter that reliably responds to a slowly changing environment, while effectively ignoring fast fluctuations. The sensitive low-frequency response was significantly faster than in predictions arising from our computational modelling, and this discrepancy was resolved by the discovery that two key galactose transcripts possess half-lives that depend on the carbon source. Finally, to explore how induction characteristics affect frequency response, we compare two S. cerevisiae strains and show that they have the same frequency response despite having markedly different induction properties. This suggests that although certain characteristics of the complex networks may differ when probed in a static environment, the system has been optimized for a robust response to a dynamically changing environment.

Chronobiology of crickets: a review.

PubMed

Tomioka, Kenji

2014-10-01

Crickets provide a good model for the study of mechanisms underlying circadian rhythms and photoperiodic responses. They show clear circadian rhythms in their overt behavior and the sensitivity of the visual system. Classical neurobiological studies revealed that a pair of optic lobes is the locus of the circadian clock controlling these rhythms and that the compound eye is the major photoreceptor necessary for synchronization to environmental light cycles. The two optic lobe clocks are mutually coupled through a neural pathway and the coupling regulates an output circadian waveform and a free-running period. Recent molecular studies revealed that the cricket's clock consists of cyclic expression of so-called clock genes and that the clock mechanism is featured by both Drosophila-like and mammalian-like traits. Molecular oscillation is also observed in some extra-optic lobe tissues and depends on the optic lobe clock in a tissue dependent manner. Interestingly, the clock is also involved in adaptation to seasonally changing environment. It fits its waveform to a given photoperiod and may be an indispensable part of a photoperiodic time-measurement mechanism. With adoption of modern molecular technologies, the cricket becomes a much more important and promising model animal for the study of circadian and photoperiodic biology.

Bioenvironmental Engineering: An Interdisciplinary Approach to Training Environmental Engineers at Rutgers University

NASA Astrophysics Data System (ADS)

Uchrin, Christoph; Krogmann, Uta; Gimenez, Daniel

2010-05-01

It is becoming increasingly apparent that environmental problems have become extremely complex, involving inter- and multidisciplinary expertise. Furthermore, the nature of environmental episodes requires practitioners who are flexible in designing appropriate solution approaches. As a result, there is a high demand for environmental engineering graduates in the professional sector as well as graduate schools. At Rutgers University, we have designed and are now delivering an undergraduate curriculum that melds a strong background in basic and applied sciences with a rigorous sequence of design oriented engineering courses, all focused on producing graduates who view the environment in a holistic sense, rather than a narrow, medium oriented manner. Since the implementation of the program in 2004 student numbers have doubled and half of the students graduate with honors. The undergraduate program is complemented by the new Environmental Engineering option of the Graduate Program in Environmental Sciences. The undergraduate program and the graduate option are served by a highly committed faculty of seven full-time members and one part-time member.

Environmental protection in Hong Kong amidst transition: Is Hong Kong ready to manage its environment by law?

NASA Astrophysics Data System (ADS)

Wing-Hung Lo, Carlos

1995-05-01

Within the context of political democratization, this article explores environmental protection in Hong Kong since the government lauched a ten-year program to “save the environment” in 1989. Examining environmental management by law from a social-choice perspective, it argues that the government has yet to reach an integrative policy orocess. Hence the preconditions for an integrative set of environmental legislation are absent. Institutionally, without a comprehensive green policy, the current arrangements lack a vision as an integrative force to promote effective coordination among various sectoral environmental coordination among various sectoral environmental programs. The dominant approach of policy and law enforcement through consultation has rendered impossible strict enforcement of environmental rules and regulations as local economic growth enjoys a priority over environmental protection. At a time of environmental awakening, the people of Hong Kong are not yet prepared awakening, the people of Hong Kong are not yet prepared to participate in environmental management in a strict legal manner. The overall observation is that Hong Kong has yet to see more mature political, legal, administrative, and social conditions for managing its environment within a legal framework.

Enviromentally sensitive patch index of desertification risk applied to the main habitats of Sicily

NASA Astrophysics Data System (ADS)

Duro, A.; Piccione, V.; Ragusa, M. A.; Rapicavoli, V.; Veneziano, V.

2017-07-01

The authors applied the MEDALUS - Mediterranean Desertification and Land Use - procedure to the most representative sicilian habitat by extension, socio-economic and environmental importance, in order to assess the risk of desertification. Thanks to the ESPI, Environmentally Sensitive Patch Index, in this paper the authors estimate the current and future regional levels of desertification risk.

A highly sensitive monoclonal antibody based biosensor for quantifying 3-5 ring polycyclic aromatic hydrocarbons (PAHs) in aqueous environmental samples.

PubMed

Li, Xin; Kaattari, Stephen L; Vogelbein, Mary A; Vadas, George G; Unger, Michael A

2016-03-01

Immunoassays based on monoclonal antibodies (mAbs) are highly sensitive for the detection of polycyclic aromatic hydrocarbons (PAHs) and can be employed to determine concentrations in near real-time. A sensitive generic mAb against PAHs, named as 2G8, was developed by a three-step screening procedure. It exhibited nearly uniformly high sensitivity against 3-ring to 5-ring unsubstituted PAHs and their common environmental methylated PAHs, with IC 50 values between 1.68-31 μg/L (ppb). 2G8 has been successfully applied on the KinExA Inline Biosensor system for quantifying 3-5 ring PAHs in aqueous environmental samples. PAHs were detected at a concentration as low as 0.2 μg/L. Furthermore, the analyses only required 10 min for each sample. To evaluate the accuracy of the 2G8-based biosensor, the total PAH concentrations in a series of environmental samples analyzed by biosensor and GC-MS were compared. In most cases, the results yielded a good correlation between methods. This indicates that generic antibody 2G8 based biosensor possesses significant promise for a low cost, rapid method for PAH determination in aqueous samples.

Asthma and the environment.

PubMed

Rosenstreich, David L; Moday, Heather J; Hudes, Golda

2003-01-01

Asthma is an environmental disease that is caused in most patients by the continual inhalation of allergens. There are many different types of indoor and outdoor allergens and the exact sensitivities to these vary between people. Thorough and continuous allergen removal is the safest and most cost-effective means of treating asthma and should be undertaken in every patient. Environmental control should be done by every asthmatic regardless of perceived or actual allergic sensitivity, both because allergy testing has a significant false-negative rate because prolonged exposure to allergen will produce new sensitivities.

Alcohol consumption promotes mammary tumor growth and insulin sensitivity

PubMed Central

Hong, Jina; Holcomb, Valerie B.; Tekle, Samrawit A.; Fan, Betty; Núñez, Nomelí P.

2010-01-01

Epidemiological data show that in women, alcohol has a beneficial effect by increasing insulin sensitivity but also a deleterious effect by increasing breast cancer risk. These effects have not been shown concurrently in an animal model of breast cancer. Our objective is to identify a mouse model of breast cancer whereby alcohol increases insulin sensitivity and promotes mammary tumorigenesis. Our results from the glucose tolerance test and the homeostasis model assessment show that alcohol consumption improved insulin sensitivity. However, alcohol-consuming mice developed larger mammary tumors and developed them earlier than water-consuming mice. In vitro results showed that alcohol exposure increased the invasiveness of breast cancer cells in a dose-dependent manner. Thus, this animal model, an in vitro model of breast cancer, may be used to elucidate the mechanism(s) by which alcohol affects breast cancer. PMID:20202743

Porphyrin-sensitized solar cells: systematic molecular optimization, coadsorption and cosensitization.

PubMed

Song, Heli; Liu, Qingyun; Xie, Yongshu

2018-02-15

As a promising low-cost solar energy conversion technique, dye-sensitized solar cells have undergone spectacular development since 1991. For practical applications, improvement of power conversion efficiency has always been one of the major research topics. Porphyrins are outstanding sensitizers endowed with strong sunlight harvesting ability in the visible region and multiple reaction sites available for functionalization. However, judicious molecular design in consideration of light-harvest, energy levels, operational dynamics, adsorption geometry and suppression of back reactions is specifically required for achieving excellent photovoltaic performance. This feature article highlights some of the recently developed porphyrin sensitizers, especially focusing on the systematic dye structure optimization approach in combination with coadsorption and cosensitization methods in pursuing higher efficiencies. Herein, we expect to provide more insights into the structure-performance correlation and molecular engineering strategies in a stepwise manner.

Maternal exposure to environmental enrichment before and during gestation influences behaviour of rat offspring in a sex-specific manner.

PubMed

Zuena, Anna Rita; Zinni, Manuela; Giuli, Chiara; Cinque, Carlo; Alemà, Giovanni Sebastiano; Giuliani, Alessandro; Catalani, Assia; Casolini, Paola; Cozzolino, Roberto

2016-09-01

The beneficial effects of Environmental Enrichment (EE) applied immediately after weaning or even in adulthood have been widely demonstrated. Less is known about the possible changes in behaviour and brain development of the progeny following the exposure of dams to EE. In order to further investigate this matter, female rats were reared in EE for 12weeks, from weaning until delivery. After having confirmed the presence of relevant behavioural effects of EE, both control and EE females underwent mating. Maternal behaviour was observed and male and female offspring were then administered a battery of behavioural test at different ages. EE mothers showed a decreased frequency of total nursing and, during the first 2days of lactation, an increase in licking/grooming behaviour. Maternal exposure to EE affected offspring behaviour in a sex-specific manner: social play behaviour and anxiety-like behaviour were increased in males but not in females and learning ability was improved only in females. As a general trend, maternal EE had a marked influence on motility in male and female offspring in both locomotor activity and swimming speed. Overall, this study highlights the importance of environmental stimulation, not only in the animals directly experiencing EE, but for their progeny too, opening the way to new hypothesis on the heritability mechanisms of behavioural traits. Copyright © 2016 Elsevier Inc. All rights reserved.

[Health management as part of leadership in public administration].

PubMed

Matyssek, A K

2012-02-01

Leadership includes two tasks within public administration: leading employees by creating healthy working conditions and being led by others. The basis of leading others in a healthy way means dealing with oneself in a healthy manner; this includes typical healthy behavior (i.e., physical activity, improved nutrition, not smoking), which allows for recovery by a good work-life balance and a sensitive dealing with one's own limits. Given these conditions of healthy self care, managers are able to act as role models and lead their employees in a healthy manner. Leading in a healthy manner means showing appreciation, being interested in the employees ("caring"), integrating them in decision-making, allowing transparency, improving the working atmosphere, and finally reducing stress and increasing resources. The latter includes social support, which decreases the danger of employees burning out. The article presents the concept of a 2-day training that is designed for managers in order to raise their awareness for duties related to health management in public administration.

Drought sensitivity predicts habitat size sensitivity in an aquatic ecosystem.

PubMed

Amundrud, Sarah L; Srivastava, Diane S

2015-07-01

Species and trophic richness often increase with habitat size. Although many ecological processes have been evoked to explain both patterns, the environmental stress associated with small habitats has rarely been considered. We propose that larger habitats may be species rich simply because their environmental conditions are within the fundamental niche of more species; larger habitats may also have more trophic levels if traits of predators render them vulnerable to environmental stress. We test this hypothesis using the aquatic insect larvae in water-filled bromeliads. In bromeliads, the probability of desiccation is greatest in small plants. For the 10 most common bromeliad insect taxa, we ask whether differences in drought tolerance and regional abundances between taxa predict community and trophic composition over a gradient of bromeliad size. First, we used bromeliad survey data to calculate the mean habitat size of occurrence of each taxon. Comparing the observed mean habitat size of occurrence to that expected from random species assembly based on differences in their regional abundances allowed us to obtain habitat size sensitivity indices (as Z scores) for the various insect taxa. Second, we obtained drought sensitivity indices by subjecting individual insects to drought and measuring the effects on relative growth rates in a mesocosm experiment. We found that drought sensitivity strongly, predicts habitat size sensitivity in bromeliad insects. However, an increase in trophic richness with habitat size could not be explained by an increased sensitivity of predators to drought, but rather by sampling effects, as predators were rare compared to lower trophic levels. This finding suggests that physiological tolerance to environmental stress can be relevant in explaining the universal increase in species with habitat size.

Environmental gram-positive mastitis treatment: in vitro sensitivity and bacteriologic cure.

PubMed

Cattell, M B; Dinsmore, R P; Belschner, A P; Carmen, J; Goodell, G

2001-09-01

A clinical trial was conducted in a large dairy herd to determine the efficacy of intramammary pirlimycin hydrochloride administration during lactation for bacteriologic clearance of gram-positive environmental clinical and subclinical mastitis infections. Quarters infected with environmental streptococci that received pirlimycin therapy (13/28) were 1.8 times more likely to resolve infection than untreated quarters (5/14). The small numbers of quarters infected with coagulase-negative staphylococci resulted in inadequate power to assess treatment differences in cure rate. Although the association was not statistically significant, quarters from cows with sensitive environmental streptococci isolates from composite samples (8/13) resolved infection with treatment at approximately twice the rate of treated quarters with resistant isolates (3/10).

Genetic Influence on Contrast Sensitivity in Middle-Aged Male Twins

PubMed Central

Cronin-Golomb, Alice; Panizzon, Matthew S.; Lyons, Michael J.; Franz, Carol E.; Grant, Michael D.; Jacobson, Kristen C.; Eisen, Seth A.; Laudate, Thomas M.; Kremen, William S.

2007-01-01

Contrast sensitivity is strongly associated with daily functioning among older adults, but the genetic and environmental contributions to this ability are unknown. Using the classical twin method, we addressed this issue by examining contrast sensitivity at five spatial frequencies (1.5–18 cycles per degree) in 718 middle-aged male twins from the Vietnam Era Twin Study of Aging (VETSA). Heritability estimates were modest (14%–38%), whereas individual-specific environmental influences accounted for 62%–86% of the variance. Identifying the types of individual-specific events that impact contrast sensitivity may suggest interventions to modulate this ability and thereby improve overall quality of life as adults age. PMID:17604073

Epigenetic Influences During the Periconception Period and Assisted Reproduction.

PubMed

Amoako, Akwasi A; Nafee, Tamer M; Ola, Bolarinde

2017-01-01

The periconception period starts 6 months before conception and lasts until the tenth week of gestation. In this chapter, we will focus on epigenetic modifications to DNA and gene expression within this period and during assisted reproduction. There are two critical times during the periconception window when significant epigenetic 'reprogramming' occur: one during gametogenesis and another during the pre-implantation embryonic stage. Furthermore, assisted conception treatments, laboratory protocols and culture media can affect the embryo development and birth weights in laboratory animals. There is, however, an ongoing debate as to whether epigenetic changes in humans, causing embryo mal-development, placenta dysfunction and birth defects, result from assisted reproductive technologies or are consequences of pre-existing medical and/or genetic conditions in the parents. The periconception period starts from ovarian folliculogenesis, through resumption of oogenesis, fertilisation, peri-implantation embryo development, embryogenesis until the end of organogenesis. In men, it is the period from spermatogenesis to epididymal sperm storage and fertilisation. Gametes and developing embryos are sensitive to environmental factors during this period, and epigenetic modifications can occur in response to adverse lifestyles and environmental factors. We now know that lifestyle factors such as advanced parentage age, obesity or undernutrition, smoking, excessive alcohol and caffeine intake and recreational drugs used during gamete production and embryogenesis could induce epigenetic alterations, which could impact adversely on pregnancy outcomes and health of the offspring. Furthermore, these can also result in a permanent and irreversible effect in a dose-dependent manner, which can be passed on to the future generations.

Response diversity, nonnative species, and disassembly rules buffer freshwater ecosystem processes from anthropogenic change.

PubMed

Moore, Jonathan W; Olden, Julian D

2017-05-01

Integrating knowledge of environmental degradation, biodiversity change, and ecosystem processes across large spatial scales remains a key challenge to illuminating the resilience of earth's systems. There is now a growing realization that the manner in which communities will respond to anthropogenic impacts will ultimately control the ecosystem consequences. Here, we examine the response of freshwater fishes and their nutrient excretion - a key ecosystem process that can control aquatic productivity - to human land development across the contiguous United States. By linking a continental-scale dataset of 533 fish species from 8100 stream locations with species functional traits, nutrient excretion, and land remote sensing, we present four key findings. First, we provide the first geographic footprint of nutrient excretion by freshwater fishes across the United States and reveal distinct local- and continental-scale heterogeneity in community excretion rates. Second, fish species exhibited substantial response diversity in their sensitivity to land development; for native species, the more tolerant species were also the species contributing greater ecosystem function in terms of nutrient excretion. Third, by modeling increased land-use change and resultant shifts in fish community composition, land development is estimated to decrease fish nutrient excretion in the majority (63%) of ecoregions. Fourth, the loss of nutrient excretion would be 28% greater if biodiversity loss was random or 84% greater if there were no nonnative species. Thus, ecosystem processes are sensitive to increased anthropogenic degradation but biotic communities provide multiple pathways for resistance and this resistance varies across space. © 2016 John Wiley & Sons Ltd.

Reduced graphene oxide-rose bengal hybrid film for improved ammonia detection with low humidity interference at room temperature

NASA Astrophysics Data System (ADS)

Midya, Anupam; Ghosh, Ruma; Santra, Sumita; Ray, Samit K.; Guha, Prasanta K.

2016-02-01

Development of chemoresistive ammonia sensor that does not suffer with humidity interference is highly desirable for practical environmental monitoring systems. We report enhanced ammonia sensing using chemically reduced graphene oxide (RGO) and rose bengal (RB) nanocomposite fabricated in a very simple and cost effective manner. The RGO-RB nanocomposites were synthesized using three different concentrations (2 mg mL-1, 5 mg mL-1 and 10 mg mL-1) of RB keeping the RGO concentration same. Ammonia and humidity sensing of these three different composites were explored. Interestingly, it was observed that with increasing concentration of RB, the sensitivity of the sensor towards ammonia was increased but the sensitivity towards humidity was decreased. The response of the nanocomposites varied from ˜9-45% against 400-2800 ppm of ammonia whereas intrinsic RGO showed a response of merely 17% against 2800 ppm of ammonia. On the other hand the response of the nanocomposite based sensor was reduced from 18% to 7% against 100% relative humidity. Also, the sensor was found to be selective towards ammonia when tested against other toxic volatile organic compounds. The limit of detection of the RGO-RB based sensor was calculated to be as low as 0.9 ppm. Field emission scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, Fourier transform infrared spectroscopy and UV-vis spectroscopy were carried out for the detailed structural characterizations of the sensing layer. These results are believed to be very useful for the cost effective fabrication of graphene based ammonia sensors which have reduced effects of humidity.

The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease

PubMed Central

Richards, Robert I.; Robertson, Sarah A.; O'Keefe, Louise V.; Fornarino, Dani; Scott, Andrew; Lardelli, Michael; Baune, Bernhard T.

2016-01-01

Neurodegenerative diseases comprise an array of progressive neurological disorders all characterized by the selective death of neurons in the central nervous system. Although, rare (familial) and common (sporadic) forms can occur for the same disease, it is unclear whether this reflects several distinct pathogenic pathways or the convergence of different causes into a common form of nerve cell death. Remarkably, neurodegenerative diseases are increasingly found to be accompanied by activation of the innate immune surveillance system normally associated with pathogen recognition and response. Innate surveillance is the cell's quality control system for the purpose of detecting such danger signals and responding in an appropriate manner. Innate surveillance is an “intelligent system,” in that the manner of response is relevant to the magnitude and duration of the threat. If possible, the threat is dealt with within the cell in which it is detected, by degrading the danger signal(s) and restoring homeostasis. If this is not successful then an inflammatory response is instigated that is aimed at restricting the spread of the threat by elevating degradative pathways, sensitizing neighboring cells, and recruiting specialized cell types to the site. If the danger signal persists, then the ultimate response can include not only the programmed cell death of the original cell, but the contents of this dead cell can also bring about the death of adjacent sensitized cells. These responses are clearly aimed at destroying the ability of the detected pathogen to propagate and spread. Innate surveillance comprises intracellular, extracellular, non-cell autonomous and systemic processes. Recent studies have revealed how multiple steps in these processes involve proteins that, through their mutation, have been linked to many familial forms of neurodegenerative disease. This suggests that individuals harboring these mutations may have an amplified response to innate-mediated damage in neural tissues, and renders innate surveillance mediated cell death a plausible common pathogenic pathway responsible for neurodegenerative diseases, in both familial and sporadic forms. Here we have assembled evidence in favor of the hypothesis that neurodegenerative disease is the cumulative result of chronic activation of the innate surveillance pathway, triggered by endogenous or environmental danger or damage associated molecular patterns in a progressively expanding cascade of inflammation, tissue damage and cell death. PMID:27242399

Does the Concept of “Sensitization” Provide a Plausible Mechanism for the Putative Link Between the Environment and Schizophrenia?

PubMed Central

Collip, Dina; Myin-Germeys, Inez; Van Os, Jim

2008-01-01

Previous evidence reviewed in Schizophrenia Bulletin suggests the importance of a range of different environmental factors in the development of psychotic illness. It is unlikely, however, that the diversity of environmental influences associated with schizophrenia can be linked to as many different underlying mechanisms. There is evidence that environmental exposures may induce, in interaction with (epi)genetic factors, psychological or physiological alterations that can be traced to a final common pathway of cognitive biases and/or altered dopamine neurotransmission, broadly referred to as “sensitization,” facilitating the onset and persistence of psychotic symptoms. At the population level, the behavioral phenotype for sensitization may be examined by quantifying, in populations exposed to environmental risk factors associated with stress or dopamine-agonist drugs, (1) the increased rate of persistence (indicating lasting sensitization) of normally transient developmental expressions of subclinical psychotic experiences and (2) the subsequent increased rate of transition to clinical psychotic disorder. PMID:18203757

I: Biomarker quantification in fish exposed to crude oil as input to species sensitivity distributions and threshold values for environmental monitoring.

PubMed

Sanni, Steinar; Björkblom, Carina; Jonsson, Henrik; Godal, Brit F; Liewenborg, Birgitta; Lyng, Emily; Pampanin, Daniela M

2017-04-01

The aim of this study was to determine a suitable set of biomarker based methods for environmental monitoring in sub-arctic and temperate offshore areas using scientific knowledge on the sensitivity of fish species to dispersed crude oil. Threshold values for environmental monitoring and risk assessment were obtained based on a quantitative comparison of biomarker responses. Turbot, halibut, salmon and sprat were exposed for up to 8 weeks to five different sub-lethal concentrations of dispersed crude oil. Biomarkers assessing PAH metabolites, oxidative stress, detoxification system I activity, genotoxicity, immunotoxicity, endocrine disruption, general cellular stress and histological changes were measured. Results showed that PAH metabolites, CYP1A/EROD, DNA adducts and histopathology rendered the most robust results across the different fish species, both in terms of sensitivity and dose-responsiveness. The reported results contributed to forming links between biomonitoring and risk assessment procedures by using biomarker species sensitivity distributions. Copyright © 2016 Elsevier Ltd. All rights reserved.

Color reproducibility and dyestuff concentration

NASA Astrophysics Data System (ADS)

Csanyi, Sandor

2002-06-01

The purpose of this study was to develop a new sensitivity index connected with color matching, which makes it possible to investigate the effects of dyestuff concentration deviations in a larger part of the color space in a comprehensive manner. By the help of computer simulation and experimental design, we examined the color differences resulting from minor concentration changes in approximately 500 formulas of different compositions, altering their total concentration and the proportion of the individual dyes in them. The new sensitivity index makes it possible for the colorist to select the recipe that is the least sensitive to concentration deviations from among the computer color formulas, as well as to add a new aspect to the ranking applied in color matching so far.

Deriving field-based species sensitivity distributions (f-SSDs) from stacked species distribution models (S-SDMs).

PubMed

Schipper, Aafke M; Posthuma, Leo; de Zwart, Dick; Huijbregts, Mark A J

2014-12-16

Quantitative relationships between species richness and single environmental factors, also called species sensitivity distributions (SSDs), are helpful to understand and predict biodiversity patterns, identify environmental management options and set environmental quality standards. However, species richness is typically dependent on a variety of environmental factors, implying that it is not straightforward to quantify SSDs from field monitoring data. Here, we present a novel and flexible approach to solve this, based on the method of stacked species distribution modeling. First, a species distribution model (SDM) is established for each species, describing its probability of occurrence in relation to multiple environmental factors. Next, the predictions of the SDMs are stacked along the gradient of each environmental factor with the remaining environmental factors at fixed levels. By varying those fixed levels, our approach can be used to investigate how field-based SSDs for a given environmental factor change in relation to changing confounding influences, including for example optimal, typical, or extreme environmental conditions. This provides an asset in the evaluation of potential management measures to reach good ecological status.

ROLE OF VIBRATIONAL SPECTROSCOPY AT THE U.S. ENVIRONMENTAL PROTECTION AGENCY'S ENVIRONMENTAL RESEARCH LABORATORY IN ATHENS, GEORGIA

EPA Science Inventory

The Environmental Research Laboratory, U.S. Environmental Protection Agency, Athens GA, is best known by vibrational spectroscopists as the laboratory where much of the pioneering work on the development of a sensitive, real-time gas chromatograph/Fourier transform infrared syste...

Saving Energy in Historic Buildings: Balancing Efficiency and Value

ERIC Educational Resources Information Center

Cluver, John H.; Randall, Brad

2012-01-01

By now the slogan of the National Trust for Historic Preservation that "the greenest building is the one already built" is widely known. In an era of increased environmental awareness and rising fuel prices, however, the question is how can historic building stock be made more energy efficient in a manner respectful of its historic…

40 CFR 49.141 - Delegation of authority of administration to the tribes.

Code of Federal Regulations, 2014 CFR

2014-07-01

... administration to the tribes. 49.141 Section 49.141 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... authority of administration to the tribes. (a) What is the purpose of this section? The purpose of this... eligibility criteria under 40 CFR 49.6 for treatment in the same manner as a State. (b) How does the Tribe...

40 CFR 49.141 - Delegation of authority of administration to the tribes.

Code of Federal Regulations, 2013 CFR

2013-07-01

... administration to the tribes. 49.141 Section 49.141 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... authority of administration to the tribes. (a) What is the purpose of this section? The purpose of this... eligibility criteria under 40 CFR 49.6 for treatment in the same manner as a State. (b) How does the Tribe...

DOE Office of Scientific and Technical Information (OSTI.GOV)

PAQUETTE,D.E.; BENNETT,D.B.; DORSCH,W.R.

THE DEPARTMENT OF ENERGY ORDER 5400.1, GENERAL ENVIRONMENTAL PROTECTION PROGRAM, REQUIRES THE DEVELOPMENT AND IMPLEMENTATION OF A GROUNDWATER PROTECTION PROGRAM. THE BNL GROUNDWATER PROTECTION MANAGEMENT PROGRAM DESCRIPTION PROVIDES AN OVERVIEW OF HOW THE LABORATORY ENSURES THAT PLANS FOR GROUNDWATER PROTECTION, MONITORING, AND RESTORATION ARE FULLY DEFINED, INTEGRATED, AND MANAGED IN A COST EFFECTIVE MANNER THAT IS CONSISTENT WITH FEDERAL, STATE, AND LOCAL REGULATIONS.

Chosen Striking Location and the User-Tool-Environment System

ERIC Educational Resources Information Center

Wagman, Jeffrey B.; Taylor, Kona R.

2004-01-01

Controlling a hand-held tool requires that the tool user bring the tool into contact with an environmental surface in a task-appropriate manner. This, in turn, requires applying muscular forces so as to overcome how the object resists being moved about its various axes. Perceived properties of hand-held objects tend to be constrained by inertial…

40 CFR 721.4040 - Glycols, polyethylene-, 3-sulfo-2-hydroxypropyl-p-(1,1,3,3-tetra-methylbutyl)phenyl ether, sodium...

Code of Federal Regulations, 2010 CFR

2010-07-01

... information, and any information on methods for protecting against such risk, into an MSDS as described at... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF... substance is any manner or method of manufacture, import, or processing associated with any use of this...

40 CFR 721.3152 - Ethanaminium, N-ethyl-2-hydroxy-N,N-bis(2-hydroxyethyl)-, diester with C12-18 fatty acids, ethyl...

Code of Federal Regulations, 2010 CFR

2010-07-01

... must incorporate this new information, and any information on methods for protecting against such risk....3152 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... significant new use of this substance is any manner or method of manufacture, import, or processing associated...

40 CFR 721.3025 - Fatty acids C12-18, C18 unsaturated, C12-18 alkyl esters (generic).

Code of Federal Regulations, 2010 CFR

2010-07-01

..., C12-18 alkyl esters (generic). 721.3025 Section 721.3025 Protection of Environment ENVIRONMENTAL... communication program. A significant new use of these substances is any manner or method of manufacture, import, or processing associated with any use of these substances without providing risk notification as...

A LEXICON OF CAVE AND KARST TERMINOLOGY WITH SPECIAL REFERENCE TO ENVIRONMENTAL KARST HYDROLOGY (2002 EDITION)

EPA Science Inventory

Several attempts to classify karst terminology in an organized manner have been attempted in the past. The last few glossaries of karst terminology were organized in the late 1960s and published in the early 1970s. Since that time, many new terms related to karst in general hav...

A Review of Technology Education in Ireland; a Changing Technological Environment Promoting Design Activity

ERIC Educational Resources Information Center

Leahy, Keelin; Phelan, Pat

2014-01-01

In Ireland, Technology Education's structure and organisation across the levels of education is not delivered or governed in a coherent manner. Technology Education in primary level education, for students between 5 and 12 years of age, does not explicitly exist as a separate subject. In primary level education, Social, Environmental and…

Greening the work force in Brazilian hotels: the role of environmental training.

PubMed

Dias-Angelo, Fernanda; Jabbour, Charbel J C; Calderaro, José Armando

2014-01-01

Organizations are increasingly required to reduce their environmental impact through the adoption of environmental management, which requires the support of human resource practices. The objective of this study is to determine whether human resource management practices, especially training, are supporting environmental management practices at four hotels located in Brazil. This research is qualitative, based on the analysis of four hotels in Brazil. Based on the systematized empirical evidence collected from four hotels (Hotels A, B, C, and D), it can be concluded that: (1) human resource management is still not fully aligned with environmental objectives at the hotels studied; (2) only Hotel B has implemented environmental management practices and aligned with human resource management in a more developed manner, which may indicate that these two variables of analysis could have interrelations; (3) environmental training as a human resource management practice was verified in all hotels analyzed. The greening of human resources practices is not fully aligned with environmental objectives in the hotels studied. If these hotels really wish to "go green," environmental training will be necessary. Hotel stakeholders play a major role in implementing the greening of the hotel industry.

Focus on Cultural Issues in Research: Developing and Implementing Native American Postcolonial Participatory Action Research.

ERIC Educational Resources Information Center

Stone, Joseph B.

Indian country presents even the most seasoned and careful researcher with numerous methodological issues. Two of the most salient of these are appropriate understanding of postcolonial stress in tribal communities, and the use of participatory action research methods and models in a culturally sensitive manner. This paper explains postcolonial…

Diapause in the Boll Weevil (Coleopetra: Curculionidae) : Life-Stage Sensitivity to Enviromental Cues

Treesearch

Terence L. Wagner; Eric J. Villavaso; Jefferey L. Willers

1999-01-01

This study examines the diapause response in naturally occurring boll weevils under field and simulated field environments of north Mississippi. Squares containing early-stage weevils were collected in July, August, and September and subsamples from each group were installed into similar dynamic environments in the laboratory. In this manner, some weevils experienced...

Parent-Child Talk about Motion: Links to Children's Development of Motion Event Language

ERIC Educational Resources Information Center

Hohenstein, Jill

2013-01-01

This study investigated the motion event language children and their parents engaged in while playing a board game. Children are sensitive to differences in manner and path at infancy, yet adult-like motion event expression appears relatively late in development. While multiple studies have examined how exposure to parent speech generally relates…

Phenomenal Permanence and the Development of Predictive Tracking in Infancy

ERIC Educational Resources Information Center

Bertenthal, Bennett I.; Longo, Matthew R.; Kenny, Sarah

2007-01-01

The perceived spatiotemporal continuity of objects depends on the way they appear and disappear as they move in the spatial layout. This study investigated whether infants' predictive tracking of a briefly occluded object is sensitive to the manner by which the object disappears and reappears. Five-, 7-, and 9-month-old infants were shown a ball…

Vantage Sensitivity: Environmental Sensitivity to Positive Experiences as a Function of Genetic Differences.

PubMed

Pluess, Michael

2017-02-01

A large number of gene-environment interaction studies provide evidence that some people are more likely to be negatively affected by adverse experiences as a function of specific genetic variants. However, such "risk" variants are surprisingly frequent in the population. Evolutionary analysis suggests that genetic variants associated with increased risk for maladaptive development under adverse environmental conditions are maintained in the population because they are also associated with advantages in response to different contextual conditions. These advantages may include (a) coexisting genetic resilience pertaining to other adverse influences, (b) a general genetic susceptibility to both low and high environmental quality, and (c) a coexisting propensity to benefit disproportionately from positive and supportive exposures, as reflected in the recent framework of vantage sensitivity. After introducing the basic properties of vantage sensitivity and highlighting conceptual similarities and differences with diathesis-stress and differential susceptibility patterns of gene-environment interaction, selected and recent empirical evidence for the notion of vantage sensitivity as a function of genetic differences is reviewed. The unique contribution that the new perspective of vantage sensitivity may make to our understanding of social inequality will be discussed after suggesting neurocognitive and molecular mechanisms hypothesized to underlie the propensity to benefit disproportionately from benevolent experiences. © 2015 Wiley Periodicals, Inc.

Environmental aspects of large-scale wind-power systems in the UK

NASA Astrophysics Data System (ADS)

Robson, A.

1984-11-01

Environmental issues relating to the introduction of large, MW-scale wind turbines at land-based sites in the UK are discussed. Noise, television interference, hazards to bird life, and visual effects are considered. Areas of uncertainty are identified, but enough is known from experience elsewhere in the world to enable the first UK machines to be introduced in a safe and environementally acceptable manner. Research to establish siting criteria more clearly, and significantly increase the potential wind-energy resource is mentioned. Studies of the comparative risk of energy systems are shown to be overpessimistic for UK wind turbines.

Application of a SERS-based lateral flow immunoassay strip for the rapid and sensitive detection of staphylococcal enterotoxin B

NASA Astrophysics Data System (ADS)

Hwang, Joonki; Lee, Sangyeop; Choo, Jaebum

2016-06-01

A novel surface-enhanced Raman scattering (SERS)-based lateral flow immunoassay (LFA) biosensor was developed to resolve problems associated with conventional LFA strips (e.g., limits in quantitative analysis and low sensitivity). In our SERS-based biosensor, Raman reporter-labeled hollow gold nanospheres (HGNs) were used as SERS detection probes instead of gold nanoparticles. With the proposed SERS-based LFA strip, the presence of a target antigen can be identified through a colour change in the test zone. Furthermore, highly sensitive quantitative evaluation is possible by measuring SERS signals from the test zone. To verify the feasibility of the SERS-based LFA strip platform, an immunoassay of staphylococcal enterotoxin B (SEB) was performed as a model reaction. The limit of detection (LOD) for SEB, as determined with the SERS-based LFA strip, was estimated to be 0.001 ng mL-1. This value is approximately three orders of magnitude more sensitive than that achieved with the corresponding ELISA-based method. The proposed SERS-based LFA strip sensor shows significant potential for the rapid and sensitive detection of target markers in a simplified manner.A novel surface-enhanced Raman scattering (SERS)-based lateral flow immunoassay (LFA) biosensor was developed to resolve problems associated with conventional LFA strips (e.g., limits in quantitative analysis and low sensitivity). In our SERS-based biosensor, Raman reporter-labeled hollow gold nanospheres (HGNs) were used as SERS detection probes instead of gold nanoparticles. With the proposed SERS-based LFA strip, the presence of a target antigen can be identified through a colour change in the test zone. Furthermore, highly sensitive quantitative evaluation is possible by measuring SERS signals from the test zone. To verify the feasibility of the SERS-based LFA strip platform, an immunoassay of staphylococcal enterotoxin B (SEB) was performed as a model reaction. The limit of detection (LOD) for SEB, as determined with the SERS-based LFA strip, was estimated to be 0.001 ng mL-1. This value is approximately three orders of magnitude more sensitive than that achieved with the corresponding ELISA-based method. The proposed SERS-based LFA strip sensor shows significant potential for the rapid and sensitive detection of target markers in a simplified manner. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr07243c

Monoallelic mutation analysis (MAMA) for identifying germline mutations.

PubMed

Papadopoulos, N; Leach, F S; Kinzler, K W; Vogelstein, B

1995-09-01

Dissection of germline mutations in a sensitive and specific manner presents a continuing challenge. In dominantly inherited diseases, mutations occur in only one allele and are often masked by the normal allele. Here we report the development of a sensitive and specific diagnostic strategy based on somatic cell hybridization termed MAMA (monoallelic mutation analysis). We have demonstrated the utility of this strategy in two different hereditary colorectal cancer syndromes, one caused by a defective tumour suppressor gene on chromosome 5 (familial adenomatous polyposis, FAP) and the other caused by a defective mismatch repair gene on chromosome 2 (hereditary non-polyposis colorectal cancer, HNPCC).

MOLECULAR DIAGNOSTICS - ANOTHER PIECE IN THE ENVIRONMENTAL PUZZLE

EPA Science Inventory

Molecular biology offers sensitive and expedient tools for the detection of exposure to environmental stressors. Molecular approaches provide the means for detection of the "first cellular event(s)" in response to environmental changes-specifically, immediate changes in gene expr...

Mechanism for initiation of food allergy: Dependence on skin barrier mutations and environmental allergen costimulation.

PubMed

Walker, Matthew T; Green, Jeremy E; Ferrie, Ryan P; Queener, Ashley M; Kaplan, Mark H; Cook-Mills, Joan M

2018-05-01

Mechanisms for the development of food allergy in neonates are unknown but clearly linked in patient populations to a genetic predisposition to skin barrier defects. Whether skin barrier defects contribute functionally to development of food allergy is unknown. The purpose of the study was to determine whether skin barrier mutations, which are primarily heterozygous in patient populations, contribute to the development of food allergy. Mice heterozygous for the filaggrin (Flg) ft and Tmem79 ma mutations were skin sensitized with environmental and food allergens. After sensitization, mice received oral challenge with food allergen, and then inflammation, inflammatory mediators, and anaphylaxis were measured. We define development of inflammation, inflammatory mediators, and food allergen-induced anaphylaxis in neonatal mice with skin barrier mutations after brief concurrent cutaneous exposure to food and environmental allergens. Moreover, neonates of allergic mothers have increased responses to suboptimal sensitization with food allergens. Importantly, responses to food allergens by these neonatal mice were dependent on genetic defects in skin barrier function and on exposure to environmental allergens. ST2 blockade during skin sensitization inhibited the development of anaphylaxis, antigen-specific IgE, and inflammatory mediators. Neonatal anaphylactic responses and antigen-specific IgE were also inhibited by oral pre-exposure to food allergen, but interestingly, this was blunted by concurrent pre-exposure of the skin to environmental allergen. These studies uncover mechanisms for food allergy sensitization and anaphylaxis in neonatal mice that are consistent with features of human early-life exposures and genetics in patients with clinical food allergy and demonstrate that changes in barrier function drive development of anaphylaxis to food allergen. Copyright © 2018 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Estimation of the sensitivity of various environmental sampling methods for detection of Salmonella in duck flocks.

PubMed

Arnold, Mark E; Mueller-Doblies, Doris; Gosling, Rebecca J; Martelli, Francesca; Davies, Robert H

2015-01-01

Reports of Salmonella in ducks in the UK currently rely upon voluntary submissions from the industry, and as there is no harmonized statutory monitoring and control programme, it is difficult to compare data from different years in order to evaluate any trends in Salmonella prevalence in relation to sampling methodology. Therefore, the aim of this project was to assess the sensitivity of a selection of environmental sampling methods, including the sampling of faeces, dust and water troughs or bowls for the detection of Salmonella in duck flocks, and a range of sampling methods were applied to 67 duck flocks. Bayesian methods in the absence of a gold standard were used to provide estimates of the sensitivity of each of the sampling methods relative to the within-flock prevalence. There was a large influence of the within-flock prevalence on the sensitivity of all sample types, with sensitivity reducing as the within-flock prevalence reduced. Boot swabs (individual and pool of four), swabs of faecally contaminated areas and whole house hand-held fabric swabs showed the overall highest sensitivity for low-prevalence flocks and are recommended for use to detect Salmonella in duck flocks. The sample type with the highest proportion positive was a pool of four hair nets used as boot swabs, but this was not the most sensitive sample for low-prevalence flocks. All the environmental sampling types (faeces swabs, litter pinches, drag swabs, water trough samples and dust) had higher sensitivity than individual faeces sampling. None of the methods consistently identified all the positive flocks, and at least 10 samples would be required for even the most sensitive method (pool of four boot swabs) to detect a 5% prevalence. The sampling of dust had a low sensitivity and is not recommended for ducks.

Deriving predicted no-effect concentrations (PNECs) for emerging contaminants in the river Po, Italy, using three approaches: Assessment factor, species sensitivity distribution and AQUATOX ecosystem modelling.

PubMed

Gredelj, Andrea; Barausse, Alberto; Grechi, Laura; Palmeri, Luca

2018-06-20

Over the past decades, per- and polyfluoroalkyl substances (PFASs) found in environmental matrices worldwide have raised concerns due to their toxicity, ubiquity and persistence. A widespread pollution of groundwater and surface waters caused by PFASs in Northern Italy has been recently discovered, becoming a major environmental issue, also because the exact risk for humans and nature posed by this contamination is unclear. Here, the Po River in Northern Italy was selected as a study area to assess the ecological risk posed by perfluoroalkyl acids (PFAAs), a class of PFASs, considering the noticeable concentration of various PFAAs detected in the Po waters over the past years. Moreover, the Po has a large environmental and socio-economic importance: it is the largest Italian river and drains a densely inhabited, intensely cultivated and heavily industrialized watershed. Predicted no-effect concentrations (PNECs) were derived using two regulated methodologies, assessment factors (AFs) and species sensitivity distribution (SSD), which rely on published ecotoxicological laboratory tests. Results were compared to those of a novel methodology using the mechanistic ecosystem model AQUATOX to compute PNECs in an ecologically-sound manner, i.e. considering physical, chemical, biological and ecological processes in the river. The model was used to quantify how the biomasses of the modelled taxa in the river food web deviated from natural conditions due to varying inputs of the chemicals. PNEC for each chemical was defined as the lowest chemical concentration causing a non-negligible yearly biomass loss for a simulated taxon with respect to a control simulation. The investigated PFAAs were Perfluorooctanoic acid (PFOA) and Perfluorooctanesulfonic acid (PFOS) as long-chained compounds, and Perfluorobutanoic acid (PFBA) and Perfluorobutanesulfonic acid (PFBS) as short-chained homologues. Two emerging contaminants, Linear Alkylbenzene Sulfonate (LAS) and triclosan, were also studied to assess the performance of the three methodologies for chemicals whose ecotoxicology and environmental fate are well-studied. The most precautionary approach was the use of AFs generally followed by SSD and then AQUATOX, except for PFOS, for which AQUATOX yielded a much lower PNEC compared to the other approaches since, unlike the other two methodologies, it explicitly simulates sublethal toxicity and indirect ecological effects. Our findings highlight that neglecting the role of ecological processes when extrapolating from laboratory tests to ecosystems can result in under-protective threshold concentrations for chemicals. Ecosystem models can complement existing laboratory-based methodologies, and the use of multiple methods for deriving PNECs can help to clarify uncertainty in ecological risk estimates. Copyright © 2018 Elsevier Ltd. All rights reserved.

Membrane loop process for separating carbon dioxide for use in gaseous form from flue gas

DOEpatents

Wijmans, Johannes G; Baker, Richard W; Merkel, Timothy C

2014-10-07

The invention is a process involving membrane-based gas separation for separating and recovering carbon dioxide emissions from combustion processes in partially concentrated form, and then transporting the carbon dioxide and using or storing it in a confined manner without concentrating it to high purity. The process of the invention involves building up the concentration of carbon dioxide in a gas flow loop between the combustion step and a membrane separation step. A portion of the carbon dioxide-enriched gas can then be withdrawn from this loop and transported, without the need to liquefy the gas or otherwise create a high-purity stream, to a destination where it is used or confined, preferably in an environmentally benign manner.

The nature and nurture of high IQ: An extended sensitive period for intellectual development

PubMed Central

Brant, Angela M; Munakata, Yuko; Boomsma, Dorret I; DeFries, John C; Haworth, Claire MA; Keller, Matthew C; Martin, Nicholas G; McGue, Matthew; Petrill, Stephen A; Plomin, Robert; Wadsworth, Sally J; Wright, Margaret J; Hewitt, John K

2015-01-01

IQ predicts many measures of life success, as well as trajectories of brain development. Prolonged cortical thickening observed in individuals with higher IQ might reflect an extended period of synaptogenesis and high environmental sensitivity or plasticity. We tested this hypothesis by examining the timing of changes in the magnitude of genetic and environmental influences on IQ as a function of IQ score. We find that individuals with higher IQ show high environmental influence on IQ into adolescence (resembling younger children), whereas individuals with lower IQ show high heritability of IQ in adolescence (resembling adults), consistent with an extended sensitive period for intellectual development in more intelligent individuals. These patterns hold across a cross-sectional sample of almost 11,000 twin pairs, and a longitudinal sample of twins, biological siblings, and adoptive siblings. PMID:23818653

The nature and nurture of high IQ: an extended sensitive period for intellectual development.

PubMed

Brant, Angela M; Munakata, Yuko; Boomsma, Dorret I; Defries, John C; Haworth, Claire M A; Keller, Matthew C; Martin, Nicholas G; McGue, Matthew; Petrill, Stephen A; Plomin, Robert; Wadsworth, Sally J; Wright, Margaret J; Hewitt, John K

2013-08-01

IQ predicts many measures of life success, as well as trajectories of brain development. Prolonged cortical thickening observed in individuals with high IQ might reflect an extended period of synaptogenesis and high environmental sensitivity or plasticity. We tested this hypothesis by examining the timing of changes in the magnitude of genetic and environmental influences on IQ as a function of IQ score. We found that individuals with high IQ show high environmental influence on IQ into adolescence (resembling younger children), whereas individuals with low IQ show high heritability of IQ in adolescence (resembling adults), a pattern consistent with an extended sensitive period for intellectual development in more-intelligent individuals. The pattern held across a cross-sectional sample of almost 11,000 twin pairs and a longitudinal sample of twins, biological siblings, and adoptive siblings.

Cisplatin-resistant lung cancer cell-derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100-5p-dependent manner.

PubMed

Qin, Xiaobing; Yu, Shaorong; Zhou, Leilei; Shi, Meiqi; Hu, Yong; Xu, Xiaoyue; Shen, Bo; Liu, Siwen; Yan, Dali; Feng, Jifeng

2017-01-01

Exosomes derived from lung cancer cells confer cisplatin (DDP) resistance to other cancer cells. However, the underlying mechanism is still unknown. A549 resistance to DDP (A549/DDP) was established. Microarray was used to analyze microRNA (miRNA) expression profiles of A549 cells, A549/DDP cells, A549 exosomes, and A549/DDP exosomes. There was a strong correlation of miRNA profiles between exosomes and their maternal cells. A total of 11 miRNAs were significantly upregulated both in A549/DDP cells compared with A549 cells and in exosomes derived from A549/DDP cells in contrast to exosomes from A549 cells. A total of 31 downregulated miRNAs were also observed. miR-100-5p was the most prominent decreased miRNA in DDP-resistant exosomes compared with the corresponding sensitive ones. Downregulated miR-100-5p was proved to be involved in DDP resistance in A549 cells, and mammalian target of rapamycin (mTOR) expression was reverse regulated by miR-100-5p. Exosomes confer recipient cells' resistance to DDP in an exosomal miR-100-5p-dependent manner with mTOR as its potential target both in vitro and in vivo. Exosomes from DDP-resistant lung cancer cells A549 can alter other lung cancer cells' sensitivity to DDP in exosomal miR-100-5p-dependent manner. Our study provides new insights into the molecular mechanism of DDP resistance in lung cancer.

A prospective evaluation of first people's health promotion program design in the goulburn-murray rivers region.

PubMed

Doyle, Joyce; Atkinson-Briggs, Sharon; Atkinson, Petah; Firebrace, Bradley; Calleja, Julie; Reilly, Rachel; Cargo, Margaret; Riley, Therese; Crumpen, Tui; Rowley, Kevin

2016-11-10

Aboriginal Community Controlled Organisations (ACCOs) provide community-focussed and culturally safe services for First Peoples in Australia, including crisis intervention and health promotion activities, in a holistic manner. The ecological model of health promotion goes some way towards describing the complexity of such health programs. The aims of this project were to: 1) identify the aims and purpose of existing health promotion programs conducted by an alliance of ACCOs in northern Victoria, Australia; and 2) evaluate the extent to which these programs are consistent with an ecological model of health promotion, addressing both individual and environmental determinants of health. The project arose from a long history of collaborative research. Three ACCOs and a university formed the Health Promotion Alliance to evaluate their health promotion programs. Local community members were trained in, and contributed to developing culturally sensitive methods for, data collection. Information on the aims and design of 88 health promotion activities making up 12 different programs across the ACCOs was systematically and prospectively collected. There was a wide range of activities addressing environmental and social determinants of health, as well as physical activity, nutrition and weight loss. The design of the great majority of activities had a minimal Western influence and were designed within a local Aboriginal cultural framework. The most common focus of the activities was social connectedness (76 %). Physical activity was represented in two thirds of the activities, and nutrition, weight loss and culture were each a focus of about half of the activities. A modified coding procedure designed to assess the ecological nature of these programs showed that they recruited from multiple settings; targeted a range of individual, social and environmental determinants; and used numerous and innovative strategies to achieve change. First Peoples' health promotion in the Goulburn-Murray Rivers region encompasses a broad range of social, cultural, lifestyle and community development activities, including reclaiming and strengthening cultural identity and social connectedness as a response to colonisation.

Modeling Dynamics of South American Rangelands to Climate Variability and Human Impact

NASA Astrophysics Data System (ADS)

Stanimirova, R.; Arevalo, P. A.; Kaufmann, R.; Maus, V.; Lesiv, M.; Havlik, P.; Friedl, M. A.

2017-12-01

The combined pressures of climate change and shifting dietary preferences are creating an urgent need to improve understanding of how climate and land management are jointly affecting the sustainability of rangelands. In particular, our ability to effectively manage rangelands in a manner that satisfies increasing demand for meat and dairy while reducing environmental impact depends on the sensitivity of rangelands to perturbations from both climate (e.g., drought) and land use (e.g., grazing). To characterize the sensitivity of rangeland vegetation to variation in climate, we analyzed gridded time series of satellite and climate data at 0.5-degree spatial resolution from 2003 to 2016 for rangeland ecosystems in South America. We used panel regression and canonical correlation to analyze the relationship between time series of enhanced vegetation index (EVI) derived from NASA's Moderate Spatial Resolution Imaging Spectroradiometer (MODIS) and gridded precipitation and air temperature data from the University of East Anglia's Climate Research Unit. To quantify the degree to which livestock management explains geographic variation of EVI, we used global livestock distribution (FAO) and feed requirements data from the Global Biosphere Management Model (GLOBIOM). Because rangeland ecosystems are sensitive to changes in meteorological variables at different time scales, we evaluated the strength of coupling between anomalies in EVI and anomalies in temperature and standardized precipitation index (SPI) data at 1-6 month lags. Our results show statistically significant relationships between EVI and precipitation during summer, fall, and winter in both tropical and subtropical agroecological zones of South America. Further, lagged precipitation effects, which reflect memory in the system, explain significant variance in winter EVI anomalies. While precipitation emerges as the dominant driver of variability in rangeland greenness, we find evidence of a management-induced signal as well. Our modeling framework integrates satellite observation, meteorological data sets, and land use/cover change information to improve our capability to monitor and manage the long-term sustainability of rangelands.

Variability in lateral carbon export from four major tributaries in the Upper Mississippi River Basin

NASA Astrophysics Data System (ADS)

Stanimirova, R.; Arevalo, P. A.; Kaufmann, R.; Maus, V.; Lesiv, M.; Havlik, P.; Friedl, M. A.

2016-12-01

The combined pressures of climate change and shifting dietary preferences are creating an urgent need to improve understanding of how climate and land management are jointly affecting the sustainability of rangelands. In particular, our ability to effectively manage rangelands in a manner that satisfies increasing demand for meat and dairy while reducing environmental impact depends on the sensitivity of rangelands to perturbations from both climate (e.g., drought) and land use (e.g., grazing). To characterize the sensitivity of rangeland vegetation to variation in climate, we analyzed gridded time series of satellite and climate data at 0.5-degree spatial resolution from 2003 to 2016 for rangeland ecosystems in South America. We used panel regression and canonical correlation to analyze the relationship between time series of enhanced vegetation index (EVI) derived from NASA's Moderate Spatial Resolution Imaging Spectroradiometer (MODIS) and gridded precipitation and air temperature data from the University of East Anglia's Climate Research Unit. To quantify the degree to which livestock management explains geographic variation of EVI, we used global livestock distribution (FAO) and feed requirements data from the Global Biosphere Management Model (GLOBIOM). Because rangeland ecosystems are sensitive to changes in meteorological variables at different time scales, we evaluated the strength of coupling between anomalies in EVI and anomalies in temperature and standardized precipitation index (SPI) data at 1-6 month lags. Our results show statistically significant relationships between EVI and precipitation during summer, fall, and winter in both tropical and subtropical agroecological zones of South America. Further, lagged precipitation effects, which reflect memory in the system, explain significant variance in winter EVI anomalies. While precipitation emerges as the dominant driver of variability in rangeland greenness, we find evidence of a management-induced signal as well. Our modeling framework integrates satellite observation, meteorological data sets, and land use/cover change information to improve our capability to monitor and manage the long-term sustainability of rangelands.

Methods proposed to achieve air quality standards for mobile sources and technology surveillance.

PubMed Central

Piver, W T

1975-01-01

The methods proposed to meet the 1975 Standards of the Clean Air Act for mobile sources are alternative antiknocks, exhaust emission control devices, and alternative engine designs. Technology surveillance analysis applied to this situation is an attempt to anticipate potential public and environmental health problems from these methods, before they happen. Components of this analysis are exhaust emission characterization, environmental transport and transformation, levels of public and environmental exposure, and the influence of economics on the selection of alternative methods. The purpose of this presentation is to show trends as a result of the interaction of these different components. In no manner can these trends be interpreted explicitly as to what will really happen. Such an analysis is necessary so that public and environmental health officials have the opportunity to act on potential problems before they become manifest. PMID:50944

Blurring the Inputs: A Natural Language Approach to Sensitivity Analysis

NASA Technical Reports Server (NTRS)

Kleb, William L.; Thompson, Richard A.; Johnston, Christopher O.

2007-01-01

To document model parameter uncertainties and to automate sensitivity analyses for numerical simulation codes, a natural-language-based method to specify tolerances has been developed. With this new method, uncertainties are expressed in a natural manner, i.e., as one would on an engineering drawing, namely, 5.25 +/- 0.01. This approach is robust and readily adapted to various application domains because it does not rely on parsing the particular structure of input file formats. Instead, tolerances of a standard format are added to existing fields within an input file. As a demonstration of the power of this simple, natural language approach, a Monte Carlo sensitivity analysis is performed for three disparate simulation codes: fluid dynamics (LAURA), radiation (HARA), and ablation (FIAT). Effort required to harness each code for sensitivity analysis was recorded to demonstrate the generality and flexibility of this new approach.

Refractive index sensor based on lateral-offset of coreless silica interferometer

NASA Astrophysics Data System (ADS)

Baharin, Nur Faizzah; Azmi, Asrul Izam; Abdullah, Ahmad Sharmi; Mohd Noor, Muhammad Yusof

2018-02-01

A compact, cost-effective and high sensitivity fiber interferometer refractive index (RI) sensor based on symmetrical offset coreless silica fiber (CSF) configuration is proposed, optimized and demonstrated. The sensor is formed by splicing a section of CSF between two CSF sections in an offset manner. Thus, two distinct optical paths are created with large index difference, the first path through the connecting CSF sections and the second path is outside the CSF through the surrounding media. RI sensing is established from direct interaction of light with surrounding media, hence high sensitivity can be achieved with a relatively compact sensor length. In the experimental work, a 1.5 mm sensor demonstrates RI sensitivity of 750 nm/RIU for RI range between 1.33 and 1.345. With the main attributes of high sensitivity and compact size, the proposed sensor can be further developed for related applications including blood diagnosis, water quality control and food industries.

Emotional intelligence predicts success in medical school.

PubMed

Libbrecht, Nele; Lievens, Filip; Carette, Bernd; Côté, Stéphane

2014-02-01

Accumulating evidence suggests that effective communication and interpersonal sensitivity during interactions between doctors and patients impact therapeutic outcomes. There is an important need to identify predictors of these behaviors, because traditional tests used in medical admissions offer limited predictions of "bedside manners" in medical practice. This study examined whether emotional intelligence would predict the performance of 367 medical students in medical school courses on communication and interpersonal sensitivity. One of the dimensions of emotional intelligence, the ability to regulate emotions, predicted performance in courses on communication and interpersonal sensitivity over the next 3 years of medical school, over and above cognitive ability and conscientiousness. Emotional intelligence did not predict performance on courses on medical subject domains. The results suggest that medical schools may better predict who will communicate effectively and show interpersonal sensitivity if they include measures of emotional intelligence in their admission systems. PsycINFO Database Record (c) 2014 APA, all rights reserved.

The depression distress amplification model in adolescents: A longitudinal examination of anxiety sensitivity cognitive concerns, depression and suicidal ideation

PubMed Central

Capron, Daniel W.; Allan, Nicholas P.; Ialongo, Nicholas S.; Leen-Feldner, Ellen; Schmidt, Norman B.

2015-01-01

Adolescents with comorbid anxiety and depression are at significantly increased risk of suicide. The recently proposed depression distress amplification model appears to have promise for explaining the relations between anxiety, depression, and suicidality, but it has not been tested in adolescents. Participants were 524 adolescents followed over two years. Baseline data for the current report were collected by trained interviewers while the adolescents were in eighth grade. Data were obtained in the same manner when the adolescents were in tenth grade. Baseline anxiety sensitivity cognitive concerns significantly predicted suicidal ideation two years later, above and beyond baseline suicidal ideation and depression. Further, consistent with the depression distress amplification model, anxiety sensitivity cognitive concerns interacted with depressive symptoms to predict suicidal ideation. This report extends the empirical and theoretical support for a relationship between anxiety sensitivity cognitive concerns and suicidality. PMID:25754194

Differential sensitivity to the environment: contribution of cognitive biases and genes to psychological wellbeing.

PubMed

Fox, E; Beevers, C G

2016-12-01

Negative cognitive biases and genetic variation have been associated with risk of psychopathology in largely independent lines of research. Here, we discuss ways in which these dynamic fields of research might be fruitfully combined. We propose that gene by environment (G × E) interactions may be mediated by selective cognitive biases and that certain forms of genetic 'reactivity' or 'sensitivity' may represent heightened sensitivity to the learning environment in a 'for better and for worse' manner. To progress knowledge in this field, we recommend including assessments of cognitive processing biases; examining G × E interactions in 'both' negative and positive environments; experimentally manipulating the environment when possible; and moving beyond single-gene effects to assess polygenic sensitivity scores. We formulate a new methodological framework encapsulating cognitive and genetic factors in the development of both psychopathology and optimal wellbeing that holds long-term promise for the development of new personalized therapies.

Fiber Grating Environmental Sensing System

DOEpatents

Schulz, Whitten L.; Udd, Eric

2003-07-29

Fiber grating environmental measurement systems are comprised of sensors that are configured to respond to changes in moisture or chemical content of the surrounding medium through the action of coatings and plates inducing strain that is measured. These sensors can also be used to monitor the interior of bonds for degradation due to aging, cracking, or chemical attack. Means to multiplex these sensors at high speed and with high sensitivity can be accomplished by using spectral filters placed to correspond to each fiber grating environmental sensor. By forming networks of spectral elements and using wavelength division multiplexing arrays of fiber grating sensors may be processed in a single fiber line allowing distributed high sensitivity, high bandwidth fiber optic grating environmental sensor systems to be realized.

Laser System Usage in the Marine Environment: Applications and Environmental Considerations

DTIC Science & Technology

2010-12-01

publications/pubs/index.html. Released by Bart Chadwick, Head Environmental Sciences Branch Under authority of Martin Machniak, Head Research...Nilsson and Lindstrom , 1983; Shelton, Gaten, and Chapman, 1985). Data on the effects of laser energy to corals also are lacking, although it can be...L. and M. Lindstrom . 1983. “Retinal Damage and Sensitivity Loss of a Light- Sensitive Crustacean Compound Eye (Cirolana borealis): Electron

Acquisition of an X-Ray Diffractometer with WAXS and SAXS for Materials Research

DTIC Science & Technology

2015-03-31

2. This ligand is known as a sensitizer for applications in dye -sensitized solar cells, and the presence of the amino groups could potentially...achieve different surface properties, thus making them excellent candidates for use as fillers in bio-based biodegradable composite materials...These CNCs are environmentally safe sustainable, biodegradable , carbon neutral, and have low environmental, health and safety risks. Figure 9 below

Global Sensitivity Analysis for Process Identification under Model Uncertainty

NASA Astrophysics Data System (ADS)

Ye, M.; Dai, H.; Walker, A. P.; Shi, L.; Yang, J.

2015-12-01

The environmental system consists of various physical, chemical, and biological processes, and environmental models are always built to simulate these processes and their interactions. For model building, improvement, and validation, it is necessary to identify important processes so that limited resources can be used to better characterize the processes. While global sensitivity analysis has been widely used to identify important processes, the process identification is always based on deterministic process conceptualization that uses a single model for representing a process. However, environmental systems are complex, and it happens often that a single process may be simulated by multiple alternative models. Ignoring the model uncertainty in process identification may lead to biased identification in that identified important processes may not be so in the real world. This study addresses this problem by developing a new method of global sensitivity analysis for process identification. The new method is based on the concept of Sobol sensitivity analysis and model averaging. Similar to the Sobol sensitivity analysis to identify important parameters, our new method evaluates variance change when a process is fixed at its different conceptualizations. The variance considers both parametric and model uncertainty using the method of model averaging. The method is demonstrated using a synthetic study of groundwater modeling that considers recharge process and parameterization process. Each process has two alternative models. Important processes of groundwater flow and transport are evaluated using our new method. The method is mathematically general, and can be applied to a wide range of environmental problems.

Uncertainty in the response of terrestrial carbon sink to environmental drivers undermines carbon-climate feedback predictions

DOE PAGES

Huntzinger, D. N.; Michalak, A. M.; Schwalm, C.; ...

2017-07-06

Terrestrial ecosystems play a vital role in regulating the accumulation of carbon (C) in the atmosphere. Understanding the factors controlling land C uptake is critical for reducing uncertainties in projections of future climate. The relative importance of changing climate, rising atmospheric CO 2, and other factors, however, remains unclear despite decades of research. Here, we use an ensemble of land models to show that models disagree on the primary driver of cumulative C uptake for 85% of vegetated land area. Disagreement is largest in model sensitivity to rising atmospheric CO 2 which shows almost twice the variability in cumulative landmore » uptake since 1901 (1 s.d. of 212.8 PgC vs. 138.5 PgC, respectively). We find that variability in CO 2 and temperature sensitivity is attributable, in part, to their compensatory effects on C uptake, whereby comparable estimates of C uptake can arise by invoking different sensitivities to key environmental conditions. Conversely, divergent estimates of C uptake can occur despite being based on the same environmental sensitivities. Together, these findings imply an important limitation to the predictability of C cycling and climate under unprecedented environmental conditions. We suggest that the carbon modeling community prioritize a probabilistic multi-model approach to generate more robust C cycle projections.« less

Uncertainty in the response of terrestrial carbon sink to environmental drivers undermines carbon-climate feedback predictions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huntzinger, D. N.; Michalak, A. M.; Schwalm, C.

2017-07-06

Terrestrial ecosystems play a vital role in regulating the accumulation of carbon (C) in the atmosphere. Understanding the factors controlling land C uptake is critical for reducing uncertainties in projections of future climate. The relative importance of changing climate, rising atmospheric CO2, and other factors, however, remains unclear despite decades of research. Here, we use an ensemble of land models to show that models disagree on the primary driver of cumulative C uptake for 85% of vegetated land area. Disagreement is largest in model sensitivity to rising atmospheric CO2 which shows almost twice the variability in cumulative land uptake sincemore » 1901 (1 s.d. of 212.8 PgC vs. 138.5 PgC, respectively). We find that variability in CO2 and temperature sensitivity is attributable, in part, to their compensatory effects on C uptake, whereby comparable estimates of C uptake can arise by invoking different sensitivities to key environmental conditions. Conversely, divergent estimates of C uptake can occur despite being based on the same environmental sensitivities. Together, these findings imply an important limitation to the predictability of C cycling and climate under unprecedented environmental conditions. We suggest that the carbon modeling community prioritize a probabilistic multi-model approach to generate more robust C cycle projections.« less

Uncertainty in the response of terrestrial carbon sink to environmental drivers undermines carbon-climate feedback predictions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huntzinger, D. N.; Michalak, A. M.; Schwalm, C.

Terrestrial ecosystems play a vital role in regulating the accumulation of carbon (C) in the atmosphere. Understanding the factors controlling land C uptake is critical for reducing uncertainties in projections of future climate. The relative importance of changing climate, rising atmospheric CO 2, and other factors, however, remains unclear despite decades of research. Here, we use an ensemble of land models to show that models disagree on the primary driver of cumulative C uptake for 85% of vegetated land area. Disagreement is largest in model sensitivity to rising atmospheric CO 2 which shows almost twice the variability in cumulative landmore » uptake since 1901 (1 s.d. of 212.8 PgC vs. 138.5 PgC, respectively). We find that variability in CO 2 and temperature sensitivity is attributable, in part, to their compensatory effects on C uptake, whereby comparable estimates of C uptake can arise by invoking different sensitivities to key environmental conditions. Conversely, divergent estimates of C uptake can occur despite being based on the same environmental sensitivities. Together, these findings imply an important limitation to the predictability of C cycling and climate under unprecedented environmental conditions. We suggest that the carbon modeling community prioritize a probabilistic multi-model approach to generate more robust C cycle projections.« less

Whole genome and transcriptome analyses of environmental antibiotic sensitive and multi-resistant Pseudomonas aeruginosa isolates exposed to waste water and tap water

PubMed Central

Schwartz, Thomas; Armant, Olivier; Bretschneider, Nancy; Hahn, Alexander; Kirchen, Silke; Seifert, Martin; Dötsch, Andreas

2015-01-01

The fitness of sensitive and resistant Pseudomonas aeruginosa in different aquatic environments depends on genetic capacities and transcriptional regulation. Therefore, an antibiotic-sensitive isolate PA30 and a multi-resistant isolate PA49 originating from waste waters were compared via whole genome and transcriptome Illumina sequencing after exposure to municipal waste water and tap water. A number of different genomic islands (e.g. PAGIs, PAPIs) were identified in the two environmental isolates beside the highly conserved core genome. Exposure to tap water and waste water exhibited similar transcriptional impacts on several gene clusters (antibiotic and metal resistance, genetic mobile elements, efflux pumps) in both environmental P. aeruginosa isolates. The MexCD-OprJ efflux pump was overexpressed in PA49 in response to waste water. The expression of resistance genes, genetic mobile elements in PA49 was independent from the water matrix. Consistently, the antibiotic sensitive strain PA30 did not show any difference in expression of the intrinsic resistance determinants and genetic mobile elements. Thus, the exposure of both isolates to polluted waste water and oligotrophic tap water resulted in similar expression profiles of mentioned genes. However, changes in environmental milieus resulted in rather unspecific transcriptional responses than selected and stimuli-specific gene regulation. PMID:25186059

A highly sensitive monoclonal antibody based biosensor for quantifying 3-5 ring polycyclic aromatic hydrocarbons (PAHs) in aqueous environmental samples

PubMed Central

Li, Xin; Kaattari, Stephen L.; Vogelbein, Mary A.; Vadas, George G.; Unger, Michael A.

2016-01-01

Immunoassays based on monoclonal antibodies (mAbs) are highly sensitive for the detection of polycyclic aromatic hydrocarbons (PAHs) and can be employed to determine concentrations in near real-time. A sensitive generic mAb against PAHs, named as 2G8, was developed by a three-step screening procedure. It exhibited nearly uniformly high sensitivity against 3-ring to 5-ring unsubstituted PAHs and their common environmental methylated PAHs, with IC50 values between 1.68–31 μg/L (ppb). 2G8 has been successfully applied on the KinExA Inline Biosensor system for quantifying 3-5 ring PAHs in aqueous environmental samples. PAHs were detected at a concentration as low as 0.2 μg/L. Furthermore, the analyses only required 10 min for each sample. To evaluate the accuracy of the 2G8-based biosensor, the total PAH concentrations in a series of environmental samples analyzed by biosensor and GC-MS were compared. In most cases, the results yielded a good correlation between methods. This indicates that generic antibody 2G8 based biosensor possesses significant promise for a low cost, rapid method for PAH determination in aqueous samples. PMID:26925369

Generation and Characterization of Environmentally Sensitive Variants of the β-Galactosidase from Lactobacillus delbrueckii subsp. bulgaricus

PubMed Central

Yoast, Sienna; Adams, Robin M.; Mainzer, Stanley E.; Moon, Keith; Palombella, Anthony L.; Schmidt, Brian F.

1994-01-01

A method is described for generating and screening variants of the β-galactosidase from Lactobacillus delbrueckii subsp. bulgaricus sensitive to several environmental stresses, with potential application in the food industry. Chemical mutagenesis with hydroxylamine or methoxylamine was performed on the β-galactosidase gene carried on an Escherichia coli expression vector. Mutants sensitive to cold, heat, low pH, low magnesium concentration, and the presence of urea were isolated by screening for reduced color development on β-galactosidase indicator plates. The mutations responsible for three variant β-galactosidases were localized, and the base substitutions were determined by DNA sequencing. The amino acid alterations associated with one low-pH-sensitive (pHs) and two urea-sensitive (Us) variants correspond to P584L (pHs1), G400S/R479Q (Us26), and G167E/E168K/E363K/V492M (Us17), respectively. Mutant pHs1 is also heat, cold, low magnesium, and urea sensitive; Us26 is also cold sensitive; and Us17 is also low-pH sensitive. PMID:16349230

A methodology for the environmental assessment of advanced coal extraction systems

NASA Technical Reports Server (NTRS)

Sullivan, P. J.; Hutchinson, C. F.; Makihara, J.; Evensizer, J.

1980-01-01

Procedures developed to identify and assess potential environment impacts of advanced mining technology as it moves from a generic concept to a more systems definition are described. Two levels of assessment are defined in terms of the design stage of the technology being evaluated. The first level of analysis is appropriate to a conceptual design. At this level it is assumed that each mining process has known and potential environmental impacts that are generic to each mining activity. By using this assumption, potential environmental impacts can be identified for new mining systems. When two or more systems have been assessed, they can be evaluated comparing potential environmental impacts. At the preliminary stage of design, a systems performance can be assessed again with more precision. At this level of systems definition, potential environmental impacts can be analyzed and their significane determined in a manner to facilitate comparisons between systems. At each level of analysis, suggestions calculated to help the designer mitigate potentially harmful impacts are provided.

Human and Environmental Toxicity of Sodium Lauryl Sulfate (SLS): Evidence for Safe Use in Household Cleaning Products.

PubMed

Bondi, Cara Am; Marks, Julia L; Wroblewski, Lauren B; Raatikainen, Heidi S; Lenox, Shannon R; Gebhardt, Kay E

2015-01-01

Environmental chemical exposure is a major concern for consumers of packaged goods. The complexity of chemical nomenclature and wide availability of scientific research provide detailed information but lends itself to misinterpretation by the lay person. For the surfactant sodium lauryl sulfate (SLS), this has resulted in a misunderstanding of the environmental health impact of the chemical and statements in the media that are not scientifically supported. This review demonstrates how scientific works can be misinterpreted and used in a manner that was not intended by the authors, while simultaneously providing insight into the true environmental health impact of SLS. SLS is an anionic surfactant commonly used in consumer household cleaning products. For decades, this chemical has been developing a negative reputation with consumers because of inaccurate interpretations of the scientific literature and confusion between SLS and chemicals with similar names. Here, we review the human and environmental toxicity profiles of SLS and demonstrate that it is safe for use in consumer household cleaning products.

Human and Environmental Toxicity of Sodium Lauryl Sulfate (SLS): Evidence for Safe Use in Household Cleaning Products

PubMed Central

Bondi, Cara AM; Marks, Julia L; Wroblewski, Lauren B; Raatikainen, Heidi S; Lenox, Shannon R; Gebhardt, Kay E

2015-01-01

Environmental chemical exposure is a major concern for consumers of packaged goods. The complexity of chemical nomenclature and wide availability of scientific research provide detailed information but lends itself to misinterpretation by the lay person. For the surfactant sodium lauryl sulfate (SLS), this has resulted in a misunderstanding of the environmental health impact of the chemical and statements in the media that are not scientifically supported. This review demonstrates how scientific works can be misinterpreted and used in a manner that was not intended by the authors, while simultaneously providing insight into the true environmental health impact of SLS. SLS is an anionic surfactant commonly used in consumer household cleaning products. For decades, this chemical has been developing a negative reputation with consumers because of inaccurate interpretations of the scientific literature and confusion between SLS and chemicals with similar names. Here, we review the human and environmental toxicity profiles of SLS and demonstrate that it is safe for use in consumer household cleaning products. PMID:26617461

Evaluation of environmental aspects significance in ISO 14001.

PubMed

Põder, Tõnis

2006-05-01

The methodological framework set by standards ISO 14001 and ISO 14004 gives only general principles for environmental aspects assessment, which is regarded as one of the most critical stages of implementing environmental management system. In Estonia, about 100 organizations have been certified to the ISO 14001. Experience obtained from numerous companies has demonstrated that limited transparency and reproducibility of the assessment process serves as a common shortcoming. Despite rather complicated assessment schemes sometimes used, the evaluation procedures have been largely based on subjective judgments because of ill-defined and inadequate assessment criteria. A comparison with some similar studies in other countries indicates a general nature of observed inconsistencies. The diversity of approaches to the aspects' assessment in concept literature and to the related problems has been discussed. The general structure of basic assessment criteria, compatible with environmental impact assessment and environmental risk analysis has also been outlined. Based on this general structure, the article presents a tiered approach to help organize the assessment in a more consistent manner.

Reward sensitivity modulates brain activity in the prefrontal cortex, ACC and striatum during task switching.

PubMed

Fuentes-Claramonte, Paola; Ávila, César; Rodríguez-Pujadas, Aina; Ventura-Campos, Noelia; Bustamante, Juan C; Costumero, Víctor; Rosell-Negre, Patricia; Barrós-Loscertales, Alfonso

2015-01-01

Current perspectives on cognitive control acknowledge that individual differences in motivational dispositions may modulate cognitive processes in the absence of reward contingencies. This work aimed to study the relationship between individual differences in Behavioral Activation System (BAS) sensitivity and the neural underpinnings involved in processing a switching cue in a task-switching paradigm. BAS sensitivity was hypothesized to modulate brain activity in frontal regions, ACC and the striatum. Twenty-eight healthy participants underwent fMRI while performing a switching task, which elicited activity in fronto-striatal regions during the processing of the switch cue. BAS sensitivity was negatively associated with activity in the lateral prefrontal cortex, anterior cingulate cortex and the ventral striatum. Combined with previous results, our data indicate that BAS sensitivity modulates the neurocognitive processes involved in task switching in a complex manner depending on task demands. Therefore, individual differences in motivational dispositions may influence cognitive processing in the absence of reward contingencies.

Reward Sensitivity Modulates Brain Activity in the Prefrontal Cortex, ACC and Striatum during Task Switching

PubMed Central

Fuentes-Claramonte, Paola; Ávila, César; Rodríguez-Pujadas, Aina; Ventura-Campos, Noelia; Bustamante, Juan C.; Costumero, Víctor; Rosell-Negre, Patricia; Barrós-Loscertales, Alfonso

2015-01-01

Current perspectives on cognitive control acknowledge that individual differences in motivational dispositions may modulate cognitive processes in the absence of reward contingencies. This work aimed to study the relationship between individual differences in Behavioral Activation System (BAS) sensitivity and the neural underpinnings involved in processing a switching cue in a task-switching paradigm. BAS sensitivity was hypothesized to modulate brain activity in frontal regions, ACC and the striatum. Twenty-eight healthy participants underwent fMRI while performing a switching task, which elicited activity in fronto-striatal regions during the processing of the switch cue. BAS sensitivity was negatively associated with activity in the lateral prefrontal cortex, anterior cingulate cortex and the ventral striatum. Combined with previous results, our data indicate that BAS sensitivity modulates the neurocognitive processes involved in task switching in a complex manner depending on task demands. Therefore, individual differences in motivational dispositions may influence cognitive processing in the absence of reward contingencies. PMID:25875640

Hybrid pathwise sensitivity methods for discrete stochastic models of chemical reaction systems.

PubMed

Wolf, Elizabeth Skubak; Anderson, David F

2015-01-21

Stochastic models are often used to help understand the behavior of intracellular biochemical processes. The most common such models are continuous time Markov chains (CTMCs). Parametric sensitivities, which are derivatives of expectations of model output quantities with respect to model parameters, are useful in this setting for a variety of applications. In this paper, we introduce a class of hybrid pathwise differentiation methods for the numerical estimation of parametric sensitivities. The new hybrid methods combine elements from the three main classes of procedures for sensitivity estimation and have a number of desirable qualities. First, the new methods are unbiased for a broad class of problems. Second, the methods are applicable to nearly any physically relevant biochemical CTMC model. Third, and as we demonstrate on several numerical examples, the new methods are quite efficient, particularly if one wishes to estimate the full gradient of parametric sensitivities. The methods are rather intuitive and utilize the multilevel Monte Carlo philosophy of splitting an expectation into separate parts and handling each in an efficient manner.

Theoretical approach to society-wide environmental quality control

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ayano, K.

1982-01-01

The study outlines the basis for a theory of societal control of environmental quality in the US based on the concepts and philosophy of company-wide quality control which has developed in Japan as a cross-disciplinary approach to problem-solving in the industrial realm. The basic concepts are: 1) every member of society, as a producer of environmental products and services for future generations, in principle has the responsibility to control the quality of his output; 2) environment quality is the quality of life, or the fitness of use of environment for humans; and 3) societal control is any activity necessary formore » quality production of environmental products and services continuously or in the long run. A motivator-hygiene theory of environmental quality is identified, and a proposal is made that the policy provision must be formulated differently between those aimed at hygiene factors of environmental quality and those aimed at motivators, the former in a collectivistic manner, the latter as an individual problem. The concept of societal cost of environmental quality is introduced. Based on the motivator-hygiene theory of environmental quality, the collectivistic and individual approaches are differentiated and discussed.« less

The Urban melting pot: A recipe for sustainable living?

NASA Astrophysics Data System (ADS)

Terblanche, Deon

2015-04-01

Many of the milestones of human development can be traced back to people assembled in groups where economies of scale, competition and social interaction stimulated innovation. Considering that more than half the global pollution now lives in cities and towns and that most of the growth in the global pollution in the remainder of this century will continue to take place in the urban environment, the question could be asked whether humankind will continue to capitalize on the traditional benefits of city life to find solutions for growing environmental challenges? By ensuring that cities are planned and operated to make best use of the prevailing climate, resources and in a manner in which its inhabitants are safe from extreme weather and environmental events there is a good chance that cities will continue to contribute to solutions. However, if cities are allowed to developed in a haphazard manner with poorly managed infrastructure which expose citizens to the dangers of a changing climate and environmental degradation, the fight for survival will overshadow the entrepreneurial spirit. There is now a window of opportunity for weather, climate, water and environmental scientists to contribute towards a more sustainable urban future by ensuring that services based on these sciences from an integrated part of urban development and management. WMO recognizes that the rapid urbanization will require new types of services making best use of science and technology and considers this problem as one of the main priorities. Such Integrated Urban Weather, Environment and Climate Services should assist cities in facing hazards such as storm surge, flooding, heat waves, and air pollution episodes, especially in changing climates. The talk will highlight some of the opportunities that exist in this regard.

Inositol 1,4,5-trisphosphate-induced calcium release in the organelle layers of the stratified, intact egg of Xenopus laevis

PubMed Central

1990-01-01

Using double-barreled, Ca2(+)-sensitive microelectrodes, we have examined the characteristics of the Ca2+ release by inositol 1,4,5- trisphosphate (Ins(1,4,5)P3) in the various layers of Xenopus laevis eggs in which the organelles had been stratified by centrifugation. Centrifugation of living eggs stratifies the organelles yet retains them in the normal cytoplasmic milieu. The local increase in intracellular free Ca2+ in each layer was directly measured under physiological conditions using theta-tubing, double-barreled, Ca2(+)- sensitive microelectrodes in which one barrel was filled with the Ca2+ sensor and the other was filled with Ins(1,4,5)P3 for microinjection. The two tips of these electrodes were very close to each other (3 microns apart) enabling us to measure the kinetics of both the highly localized intracellular Ca2+ release and its subsequent removal in response to Ins(1,4,5)P3 injection. Upon Ins(1,4,5)P3 injection, the ER- enriched layer exhibited the largest release of Ca2+ in a dosage- dependent manner, whereas the other layers, mitochondria, lipid, and yolk, released 10-fold less Ca2+ in a dosage-independent manner. The removal of released Ca2+ took place within approximately 1 min. The sensitivity to Ins(1,4,5)P3 and the time course of intracellular Ca2+ release in the unstratified (unactivated) egg is nearly identical to that observed in the ER layer of the stratified egg. Our data suggest that the ER is the major organelle of the Ins(1,4,5)P3-sensitive Ca2+ store in the egg of Xenopus laevis. PMID:2324195

Unified physical mechanism of frequency-domain controlled-source electromagnetic exploration on land and in ocean

NASA Astrophysics Data System (ADS)

Liu, Changsheng; Lin, Jun; Zhou, Fengdao; Hu, Ruihua; Sun, Caitang

2013-12-01

The frequency-domain controlled-source electromagnetic method (FDCSEM) has played an important role in the terrestrial and oceanic exploration. However, the measuring manners and the detecting abilities in two kinds of environment are much different. This paper analyses the electromagnetic theories of the FDCSEM exploration on land and in ocean, simulates the electromagnetic responses in the two cases based on a united physical and mathematical model, and studies the physical mechanism leading to these differences. In this study, the relationship between the propagation paths and the detecting ability is illuminated and the way to improve the detecting ability of FDCSEM is brought forward. In terrestrial exploration, FDCSEM widely adopts the measuring manner of controlled-source audio-frequency magnetotelluric method (CSAMT), which records the electromagnetic fields in the far zone in the broadside direction of an electric dipole source. This manner utilizes the airwave (i.e. the Earth surface wave) and takes the stratum wave as interference. It is sensitive to the conductive target but insensitive to the resistive one. In oceanic exploration, FDCSEM usually adopts the measuring manner of marine controlled-source electromagnetic method (MCSEM), which records the electromagnetic fields, commonly the horizontal electric fields, in the in-line direction of the electric dipole source. This manner utilizes the stratum wave (i.e. the seafloor wave and the guided wave in resistive targets) and takes the airwave as interference. It is sensitive to the resistive target but relatively insensitive to the conductive one. The numerical simulation shows that both the airwave and the stratum wave contribute to the FDCSEM exploration. United utilization of them will enhance the anomalies of targets and congregate the advantages of CSAMT and MCSEM theories. At different azimuth and different offset, the contribution of the airwave and the stratum wave to electromagnetic anomaly is different. Observation at moderate offset in the in-line direction is the best choice for the exploration of resistive targets, no matter the environment is land or shallow sea. It is also the best choice for the exploration of conductive targets in terrestrial environment. As for the conductive targets in shallow sea, observation at moderate offset in the broadside direction is better. Synthetic and felicitous utilization of the airwave and the stratum wave will optimize the performance of FDCSEM.

Quantification of rapid environmental redox processes with quick-scanning x-ray absorption spectroscopy (Q-XAS)

PubMed Central

Ginder-Vogel, Matthew; Landrot, Gautier; Fischel, Jason S.; Sparks, Donald L.

2009-01-01

Quantification of the initial rates of environmental reactions at the mineral/water interface is a fundamental prerequisite to determining reaction mechanisms and contaminant transport modeling and predicting environmental risk. Until recently, experimental techniques with adequate time resolution and elemental sensitivity to measure initial rates of the wide variety of environmental reactions were quite limited. Techniques such as electron paramagnetic resonance and Fourier transform infrared spectroscopies suffer from limited elemental specificity and poor sensitivity to inorganic elements, respectively. Ex situ analysis of batch and stirred-flow systems provides high elemental sensitivity; however, their time resolution is inadequate to characterize rapid environmental reactions. Here we apply quick-scanning x-ray absorption spectroscopy (Q-XAS), at sub-second time-scales, to measure the initial oxidation rate of As(III) to As(V) by hydrous manganese(IV) oxide. Using Q-XAS, As(III) and As(V) concentrations were determined every 0.98 s in batch reactions. The initial apparent As(III) depletion rate constants (t < 30 s) measured with Q-XAS are nearly twice as large as rate constants measured with traditional analytical techniques. Our results demonstrate the importance of developing analytical techniques capable of analyzing environmental reactions on the same time scale as they occur. Given the high sensitivity, elemental specificity, and time resolution of Q-XAS, it has many potential applications. They could include measuring not only redox reactions but also dissolution/precipitation reactions, such as the formation and/or reductive dissolution of Fe(III) (hydr)oxides, solid-phase transformations (i.e., formation of layered-double hydroxide minerals), or almost any other reaction occurring in aqueous media that can be measured using x-ray absorption spectroscopy. PMID:19805269

CHARACTERIZATION OF VIRAL RNA EXTRACTION EFFICIENCY FROM ENVIRONMENTAL WATERS

EPA Science Inventory

Inhibition of PCR by environmental factors is a common problem affecting the sensitive detection of pathogenic microorganisms in environmental waters. This inhibition is caused by one of three mechanisms: 1) failure to lyse the microorganism, 2) degradation or sequestering of the...

40 CFR 766.18 - Method sensitivity.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Method sensitivity. 766.18 Section 766.18 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS General Provisions § 766.18 Method sensitivity. The target level of...

40 CFR 766.18 - Method sensitivity.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Method sensitivity. 766.18 Section 766.18 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS General Provisions § 766.18 Method sensitivity. The target level of...

40 CFR 766.18 - Method sensitivity.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Method sensitivity. 766.18 Section 766.18 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS General Provisions § 766.18 Method sensitivity. The target level of...

40 CFR 766.18 - Method sensitivity.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Method sensitivity. 766.18 Section 766.18 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS General Provisions § 766.18 Method sensitivity. The target level of...

40 CFR 766.18 - Method sensitivity.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Method sensitivity. 766.18 Section 766.18 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT DIBENZO-PARA-DIOXINS/DIBENZOFURANS General Provisions § 766.18 Method sensitivity. The target level of...

Predictive Uncertainty And Parameter Sensitivity Of A Sediment-Flux Model: Nitrogen Flux and Sediment Oxygen Demand

EPA Science Inventory

Estimating model predictive uncertainty is imperative to informed environmental decision making and management of water resources. This paper applies the Generalized Sensitivity Analysis (GSA) to examine parameter sensitivity and the Generalized Likelihood Uncertainty Estimation...

Evaluation of in silico development of aquatic toxicity species sensitivity distributions

EPA Science Inventory

Determining the sensitivity of a diversity of species to environmental contaminants continues to be a significant challenge in ecological risk assessment because toxicity data are generally limited to a few standard test species. This study assessed whether species sensitivity d...

Status of DOE efforts to renew acceptance of foreign research reactor spent nuclear fuel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Head, C.R.

1997-08-01

This presentation summarizes the efforts being made by the Department of Energy to renew acceptance of spent nuclear fuel shipments from foreign research reactors. The author reviews the actions undertaken in this process in a fairly chronological manner, through the present time, as well as the development of an environmental impact statement to support the proposed actions.

47 CFR 95.206 - (R/C Rule 6) Are there any special restrictions on the location of my R/C station?

Code of Federal Regulations, 2011 CFR

2011-10-01

... COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Radio Control (R/C) Radio... operated in such a manner as to raise environmental problems, under § 1.1307 of this chapter, you must... order to resolve or mitigate any potential interference problem with the Arecibo Observatory. If the...

47 CFR 95.206 - (R/C Rule 6) Are there any special restrictions on the location of my R/C station?

Code of Federal Regulations, 2010 CFR

2010-10-01

... COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Radio Control (R/C) Radio... operated in such a manner as to raise environmental problems, under § 1.1307 of this chapter, you must... order to resolve or mitigate any potential interference problem with the Arecibo Observatory. If the...

40 CFR 721.1750 - 1H-Benzotriazole, 5-(pen-tyl-oxy)- and 1H-ben-zo-tri-a-zole, 5-(pen-tyl-oxy)-, sodium and...

Code of Federal Regulations, 2010 CFR

2010-07-01

... this new information, and any information on methods for protecting against such risk, into a MSDS as... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... these substances is any manner or method of manufacture, import, or processing associated with any use...

77 FR 42761 - Final Environmental Impact Statement for the Oil and Gas Management Plan at Big South Fork...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... conducted in a manner that protects park resources and values, visitor use and experience, and human health... following libraries: McCreary County Public Library 6 North Main Whitley City, KY 42653 Oneida Public Library 290 South Main Street Oneida, TN 37841-2607 Fentress County Public Library 306 South Main Street...

77 FR 6787 - Notice of Intent To Prepare a Supplemental Environmental Impact Statement for a Live-Fire...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-09

... the community's ability to access the cultural sites of Pagat Village and Pagat Cave. In response to... about locating Surface Danger Zones for the ranges over Pagat Village and Pagat Cave, in January 2011... manner that would not impact access to Pagat Village and Cave via the existing trail. The DoN further...

Solvent cleaning system and method for removing contaminants from solvent used in resin recycling

DOEpatents

Bohnert, George W [Harrisonville, MO; Hand, Thomas E [Lee's Summit, MO; DeLaurentiis, Gary M [Jamestown, CA

2009-01-06

A two step solvent and carbon dioxide based system that produces essentially contaminant-free synthetic resin material and which further includes a solvent cleaning system for periodically removing the contaminants from the solvent so that the solvent can be reused and the contaminants can be collected and safely discarded in an environmentally safe manner.