ESA switches its infrared space telescope off and will clean its orbit

NASA Astrophysics Data System (ADS)

1998-05-01

Controllers at the ESA ground station at Villafranca (Madrid, Spain) witnessed the definitive end for the telescope but they didn't have to press any 'red button' or the like. The instructions for the switch off had already been introduced into ISO's computer earlier. ISO's last month of life was used to gather as much technical data as possible. Various software and hardware systems that, due to the superb performance of the spacecraft, did not have to be used during the operational phase were subjected to detailed tests. Results from these tests will benefit future ESA missions, such as XMM and Integral, which use some of the same components, such as the Star Trackers guiding the spacecraft. Also, ISO's farewell included a further last gift for the astronomers. A few of the detectors in the Short Wavelength Spectrometer (SWS), one of the four instruments on-board the satellite, could still be used after exhaustion of the liquid helium. In anticipation of this opportunity, a special scientific programme has been prepared and was interleaved with the technology tests. Some 150 extra hours were used to measure nearly 300 stars at wavelengths between 2.4 and 4 microns enabling astronomers to make a detailed spectral classification. In fact, ISO continued to give scientific surprises to the very sad end. ISO's 'last light' observation - taken with the SWS instrument just before midnight on May 10 - was of emission lined from hydrogen in hot supergiant star (eta Canis Majoris). The preliminary results show that this star, supposed to be ordinary, is probably surrounded by a disk of matter. Commenting on the satellite switch off, ESA's Director of Science, Roger Bonnet, said "ISO has allowed us to gain the first clear view of the universe at infrared wavelengths. A great amount of work still awaits us to interpret all ISO's exciting discoveries. We will miss ISO, of course - new answers always bring new questions and the wish for yet more knowledge; that is why ESA is already working on one of ISO's successors, the Far Infrared and Submillimetre Space Telescope, FIRST. Footnote about ISO ISO was put into orbit in November 1995, by an Ariane 44P launcher at Europe's Spaceport at Kourou in French Guiana. As an unprecedented observatory for infrared astronomy, able to examine cool and hidden places in the Universe, ISO has successfully made more than 26,000 observations. A supply of liquid helium, used to cool the telescope and instruments close to the absolute zero of temperature, lasted more than 30% longer than expected, but ran out on 8 April 1998 (see ESA Press Information Note No.11-98 of 9 April).

EnviroAtlas - NatureServe Analysis of Imperiled or Federally Listed Species by HUC-12 for the Conterminous United States

EPA Pesticide Factsheets

This EnviroAtlas dataset includes analysis by NatureServe of species that are Imperiled (G1/G2) or Listed under the U.S. Endangered Species Act (ESA) by 12-digit Hydrologic Units (HUCs). The analysis results are for use and publication by both the LandScope America website and by the EnviroAtlas. Results are provided for the total number of Aquatic Associated G1-G2/ESA species, the total number of Wetland Associated G1-G2/ESA species, the total number of Terrestrial Associated G1-G2/ESA species, and the total number of Unknown Habitat Association G1-G2/ESA species in each HUC12. NatureServe is a non-profit organization dedicated to developing and providing information about the world's plants, animals, and ecological communities. NatureServe works in partnership with 82 independent Natural Heritage programs and Conservation Data Centers that gather scientific information on rare species and ecosystems in the United States, Latin America, and Canada (the Natural Heritage Network). NatureServe is a leading source for biodiversity information that is essential for effective conservation action. This dataset was produced by NatureServe to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data

ESA is now a major player in global space science

NASA Astrophysics Data System (ADS)

1997-07-01

* Results from the star-fixing satellite Hipparcos, released this summer to the world's astronomers, give the positions and motions of 118,000 stars a hundred times more accurately than ever before. * Every day the Infrared Space Observatory, ISO, examines 45 cosmic objects on average at many different wavelengths never observable before, giving fresh insights into cosmic history and chemistry. * Invaluable new knowledge of the Sun comes from SOHO, the Solar and Heliospheric Observatory, which is the first spacecraft able to observe the Sun's deep interior as well as its stormy surface and atmosphere. Besides these missions making present headlines, several other spacecraft are helping to fulfil ESA's scientific objectives. * 2 - * The launch in October 1997 of ESA's probe Huygens, aboard the Cassini spacecraft bound for Saturn, foreshadows a breakthrough in planetary science in 2004. That is when Huygens will carry its scientific instruments into the unique and puzzling atmosphere of Saturn's moon Titan. * Ulysses, also built in Europe, is exploring hitherto unknown regions of space, after making the first-ever visit to the Sun's polar regions in 1994-95. It will return to the Sun in 2000-2001, to observe the effects of the climax of solar activity due at that time. * The Cluster 2 mission, announced in April 1997 and to be launched in 2000, will explore the Earth's space environment far more throughly than ever before. ESA's decision to replace the four Cluster satellites lost in a launch accident in 1996 ensures that Europe will continue as the leader in solar-terrestrial research in space. * An example of the three unique 58-mirror X-ray telescopes for the XMM mission was unveiled for the press in May 1997. When it goes into orbit in 1999 XMM will make, in seconds, observations of cosmic objects that took hours with previous X-ray astronomy missions. * The Hubble Space Telescope, in which ESA is a partner, continues to deliver the sharpest pictures of the cosmos after its February 1997 refurbishment. Europe's astronomers make outstanding use of their right to make observations with Hubble, guaranteed by ESA's participation. ESA's table d'h^te for space scientists To provide world-class opportunities in space for Europe's scientific community is one of ESA's primary duties. The successes summarized here are not a matter of luck, but of decades of sustained planning and effort. Although ESA's science budget is small as compared with NASA=s equivalent programme, and is even being squeezed, yet every one of ESA's missions is first in its class. * 3- The scientists of ESA's member states draw up the table d'h^te, with a balanced menu of research opportunities in Solar System exploration and in astronomy. ESA coordinates the technological and scientific efforts across Europe needed to accomplish the missions, after many years of preparation and sometimes adversity. One of ESA's strengths is that it sticks to its promises, and maintains a balance with several small missions, remaining alert to new tasks for short-term projects. Besides the spacecraft mentioned earlier, ESA is actively working on: * Rosetta. As the successor to the very successful comet mission Giotto, which intercepted Halley's Comet in 1986 and Comet Grigg-Skjellerup in 1992, Rosetta will confirm ESA's role as the world leader in comet science. To be launched in 2003, Rosetta will rendezvous with Comet Wirtanen, and fly in close orbit around it as it makes its closest approach to the Sun ten years later. * Integral. Adapted from the XMM spacecraft to save money, Integral will go into orbit in 2001 and renew ESA's role in gamma-ray astronomy, pioneered in its COS-B mission some twenty years ago. Gamma-rays reveal the most violent events in the Universe, including the gamma-ray bursts that are exciting astronomers greatly at present. * FIRST and Planck Surveyor. FIRST is a long-standing major project to extend the scope of infrared space astronomy to wavelengths longer than ISO's. Planck Surveyor was recently selected as a medium-scale project, to chart the cosmic microwave background carefully enough to trace the origin of the galaxies. ESA is now examining the option of combining these two missions in a single spacecraft, for launching in 2005. Prominent among other enticing possibilities is Mars Express, a high-level, low-cost mission that could set off for the Red Planet in 2003. It would give Europe an important stake in the exploration of Mars, by remote sensing from an orbiter and by experiments in landers. The latter can exploit ESA=s experience in preparing for the Huygens mission to Titan. Some of the Mars experiments should be readily adaptable from instruments prepared for other missions. -4- ESA is also considering SMART missions, using small satellites to test key technologies. Solar-electric propulsion, long seen as a much-needed advance in spacecraft engines, could take a small spacecraft to the Moon and then onwards to an asteroid. A second candidate for a SMART mission would develop Adrag free@ technologies for testing Einstein=s theory of gravity. Other possibilities under review include participation in a replacement for the Hubble Space Telescope, and opportunities for science associated with the International Space Station. In addition, three major projects have been selected by Europe=s space scientists as long-term goals. A spacecraft to orbit the hot planet Mercury, barely explored till now, will shed new light on the history of the Solar System. An astronomical interferometric mission using two or more telescopes in combination will observe the stars and galaxies more accurately by visible or infrared light. And a novel kind of astronomy is promised by an ambitious gravitational-wave mission to detect radiation predicted by Einstein's theory of gravity, which supposedly stretches and squeezes space itself. In short, ESA is delivering superb space science and, if future funding allows, has exciting ideas for the new millennium. Note to Editors : A picture is available of a huge cloud of hydrogen gas around Comet Hale-Bopp. This image illustrates two areas of space science where ESA leads : comet research and solar research. The image is from SOHO=s SWAN instrument, the primary task of which is to chart the solar wind. Note : To learn more about ESA, visit the ESA homepage on the World Wide Web at the new address : http://www.esa.int

Gravitational-wave Mission Study

NASA Technical Reports Server (NTRS)

Mcnamara, Paul; Jennrich, Oliver; Stebbins, Robin T.

2014-01-01

In November 2013, ESA selected the science theme, the "Gravitational Universe," for its third large mission opportunity, known as L3, under its Cosmic Vision Programme. The planned launch date is 2034. ESA is considering a 20% participation by an international partner, and NASA's Astrophysics Division has indicated an interest in participating. We have studied the design consequences of a NASA contribution, evaluated the science benefits and identified the technology requirements for hardware that could be delivered by NASA. The European community proposed a strawman mission concept, called eLISA, having two measurement arms, derived from the well studied LISA (Laser Interferometer Space Antenna) concept. The US community is promoting a mission concept known as SGO Mid (Space-based Gravitational-wave Observatory Mid-sized), a three arm LISA-like concept. If NASA were to partner with ESA, the eLISA concept could be transformed to SGO Mid by the addition of a third arm, augmenting science, reducing risk and reducing non-recurring engineering costs. The characteristics of the mission concepts and the relative science performance of eLISA, SGO Mid and LISA are described. Note that all results are based on models, methods and assumptions used in NASA studies

DISCOS- Current Status and Future Developments

NASA Astrophysics Data System (ADS)

Flohrer, T.; Lemmens, S.; Bastida Virgili, B.; Krag, H.; Klinkrad, H.; Parrilla, E.; Sanchez, N.; Oliveira, J.; Pina, F.

2013-08-01

We present ESA's Database and Information System Characterizing Objects in Space (DISCOS). DISCOS not only plays an essential role in the collision avoidance and re-entry prediction services provided by ESA's Space Debris Office, it is also providing input to numerous and very differently scoped engineering activities, within ESA and throughout industry. We introduce the central functionalities of DISCOS, present the available reporting capabilities, and describe selected data modelling features. Finally, we revisit the developments of the recent years and take a sneak preview of the on-going replacement of DISCOS web front-end.

48 CFR 522.805 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OFCCP regional office. A list of these offices can be found at http://www.dol.gov/esa/contacts/ofccp/ofcpkeyp.htm. (c) The EEO poster required by FAR 22.805(b) can be found at: http://www.dol.gov/esa/regs... contracting officer shall advise contractors to complete the Employer Information Report (EEO-1) at http://www...

Alert Exchange Process Protocol

NASA Technical Reports Server (NTRS)

Groen, Frank

2015-01-01

The National Aeronautics and Space Administration of the United States of America (NASA), and the European Space Agency (ESA), and the Japanese Aerospace Exploration Agency (JAXA), acknowledging that NASA, ESA and JAXA have a mutual interest in exchanging Alerts and Alert Status Lists to enhance the information base for each system participant while fortifying the general level of cooperation between the policy agreement subscribers, and each Party will exchange Alert listings on regular basis and detailed Alert information on a need to know basis to the extent permitted by law.

Strengthening the Security of ESA Ground Data Systems

NASA Astrophysics Data System (ADS)

Flentge, Felix; Eggleston, James; Garcia Mateos, Marc

2013-08-01

A common approach to address information security has been implemented in ESA's Mission Operations (MOI) Infrastructure during the last years. This paper reports on the specific challenges to the Data Systems domain within the MOI and how security can be properly managed with an Information Security Management System (ISMS) according to ISO 27001. Results of an initial security risk assessment are reported and the different types of security controls that are being implemented in order to reduce the risks are briefly described.

Follow the Mars Express launch from one of ESA's establishments

NASA Astrophysics Data System (ADS)

2003-05-01

Europe’s first mission to the Red Planet will reach its target in December, after a six-month journey. Mars Express will help scientists answer questions about the Martian landscape, atmosphere and the origin of life that remain open, although a wealth of information is already available. Media representatives in Europe can follow the launch and initial orbital operations at ESA/Darmstadt (ESOC) in Germany, which will be acting as the main European press centre, or ESA/Noordwijk (ESTEC) in the Netherlands. ESA/Frascati (ESRIN) in Italy and the Italian Space Agency, ASI, are organising a joint event at the University of Rome. ESA/Villafranca (VILSPA) and the CDTI, the Spanish institution in charge of space issues, are organising a joint event in Spain at the Museo Principe Felipe de la Ciudad de las Artes y las Ciencias in Valencia. At each site ESA specialists will be available for interviews. Media representatives wishing to attend are requested to complete the attached reply form and fax it to the Communication Office at the establishment of their choice. The ESA TV Service will provide live televised coverage of the launch and initial orbital operations with English commentary, between 19:15 and 22:00 CEST. Satellite: Astra 2C at 19 degrees East Reception frequency: 10832 MHz Polarisation: Horizontal Symbol rate: 22 Msymb/s FEC: 5/6 Service ID: 61950 Service name: ESA TXT: none Details of the transmission schedule and satellite details for the various pre-launch Video News Releases can be found on http://television.esa.int. The launch can also be followed live on the internet at www.esa.int/marsexpresslaunch starting at 19:15 hrs. Here you can also find the launch diary, news, press releases, videos, images and more.

A Comparative Analysis on the Temporal and Spatial Distribution of Fire Characteristics in the Amazon and Equatorial Southern Africa Using Observations from Space

NASA Astrophysics Data System (ADS)

Tang, Wenfu; Arellano, Avelino. F.; Raman, Aishwarya

2015-04-01

Tropical forest fires significantly impact atmospheric composition and regional and global climate. In particular, fires in Equatorial Southern Africa (ESA) and Amazon comprise the two largest contributors to fire emissions of chemically and radiatively-active atmospheric constituents (such as CO, BC, CO2) across the globe. Here, we investigate the spatiotemporal trends in fire characteristics between these regions using combustion signatures observed from space. Our main goals are: 1) To identify key relationships between the trends in co-emitted constituents across these regions, and, 2) To explore linkages of the observed trends in fire characteristics with the main drivers of change such as meteorology, fire practice, development patterns, and ecosystem feedbacks. We take advantage of the similarity in latitude and land area between these regions in understanding some of these drivers. Our approach begins with a multi-species analysis of trends in the observed abundance of CO, NO2, and aerosols over these regions and across the time period 2004 to 2014. We use multi-spectral retrievals of CO from Measurements Of Pollution In The Troposphere (MOPITT), tropospheric column retrievals of NO2 from Ozone Monitoring Instrument (OMI), and aerosol optical depth retrievals from Moderate Resolution Imaging Spectroradiometer (MODIS) instrument. The long records from these retrievals provide a unique opportunity to study atmospheric composition across the most recent decade. While several studies in the past have reported trends over these regions, most of these studies have focused on a particular constituent. A unique aspect of this work involves understanding covariations in co-emitted constituents to provide a more comprehensive look at fire characteristics and behavior, which are yet to be fully understood. Our initial results show that the annual average of CO for ESA (~115 ppbv) is greater than that of Amazon (110 ppbv). This pattern is also seen in NO2 (ESA : ~215 pptv ; Amazon : ~155 pptv). The standard deviation of CO is higher in Amazon (50 ppbv) when compared to ESA (35 ppbv) whereas NO2 shows similar standard deviation in Amazon and ESA (70-90 pptv). We also find changes in the timing patterns of the large fire events across these regions. Since this has important implications to changes in fire behavior (smoldering and flaming phase), we also investigated retrievals of fire radiative power (FRP) from MODIS and information on land cover change and deforestation. We find FRP patterns consistent with our results. Finally, we will explore other measurements available during this period (aircraft field campaigns and in-situ observations) and compare with current fire emission models, such as the Global Fire Emission Database (GFED) to test the robustness of our findings. We note that this exploratory work provides a unique perspective of fire characteristics that will be useful to improve predictive capability of fire emission and atmospheric models for the Amazon and ESA.

Erythropoietin-Stimulating Agents and Survival in End-Stage Renal Disease: Comparison of Payment Policy Analysis, Instrumental Variables, and Multiple Imputation of Potential Outcomes

PubMed Central

Dore, David D.; Swaminathan, Shailender; Gutman, Roee; Trivedi, Amal N.; Mor, Vincent

2013-01-01

Objective To compare the assumptions and estimands across three approaches to estimating the effect of erythropoietin-stimulating agents (ESAs) on mortality. Study Design and Setting Using data from the Renal Management Information System, we conducted two analyses utilizing a change to bundled payment that we hypothesized mimicked random assignment to ESA (pre-post, difference-in-difference, and instrumental variable analyses). A third analysis was based on multiply imputing potential outcomes using propensity scores. Results There were 311,087 recipients of ESAs and 13,095 non-recipients. In the pre-post comparison, we identified no clear relationship between bundled payment (measured by calendar time) and the incidence of death within six months (risk difference -1.5%; 95% CI - 7.0% to 4.0%). In the instrumental variable analysis, the risk of mortality was similar among ESA recipients (risk difference -0.9%; 95% CI -2.1 to 0.3). In the multiple imputation analysis, we observed a 4.2% (95% CI 3.4% to 4.9%) absolute reduction in mortality risk with use of ESAs, but closer to the null for patients with baseline hematocrit >36%. Conclusion Methods emanating from different disciplines often rely on different assumptions, but can be informative about a similar causal contrast. The implications of these distinct approaches are discussed. PMID:23849152

In Brief: European Earth science network for postdocs

NASA Astrophysics Data System (ADS)

Showstack, Randy

2008-12-01

The European Space Agency (ESA) has launched a new initiative called the Changing Earth Science Network, to support young scientists undertaking leading-edge research activities aimed at advancing the understanding of the Earth system. The initiative will enable up to 10 young postdoctoral researchers from the agency's member states to address major scientific challenges by using Earth observation (EO) satellite data from ESA and its third-party missions. The initiative aims to foster the development of a network of young scientists in Europe with a good knowledge of the agency and its EO programs. Selected candidates will have the option to carry out part of their research in an ESA center as a visiting scientist. The deadline to submit proposals is 16 January 2009. Selections will be announced in early 2009. The Changing Earth Science Network was developed as one of the main programmatic components of ESA's Support to Science Element, launched in 2008. For more information, visit http://www.esa.int/stse.

75 FR 41436 - Endangered and Threatened Wildlife; Notice of 90-Day Finding on a Petition to Revise Critical...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-16

... Revise Critical Habitat for the Endangered Leatherback Sea Turtle Under the Endangered Species Act (ESA... Endangered Species Act (ESA). We find that the petition does not present substantial scientific information... Service and the National Marine Fisheries Service in Joint Administration of the Endangered Species Act of...

77 FR 22760 - Endangered and Threatened Species; Notice of Intent To Update a Recovery Plan for the Blue Whale...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-17

... Recovery Plan for the North Pacific Right Whale AGENCY: National Marine Fisheries Service (NMFS), National... recovery plans; request for information. SUMMARY: The National Marine Fisheries Service (NMFS) is... ESA. The recovery planning process is guided by the statutory language of Section 4(f) of the ESA and...

KSC-2013-2880

NASA Image and Video Library

2013-06-20

CAPE CANAVERAL, Fla. – Representatives from the European Space Agency, or ESA, toured the Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida. From the left, are Nico Dettman, ESA Space Transportation Department director Bernardo Patti, ESA manager of International Space Station Operations Philippe Deloo, ESA European Service Module study manager and Mark Geyer, Orion Production Operations manager. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

KSC-2013-2884

NASA Image and Video Library

2013-06-20

CAPE CANAVERAL, Fla. – Representatives from the European Space Agency, or ESA, toured the Operations and Checkout Building high bay and viewed the Orion crew module at NASA’s Kennedy Space Center in Florida. Among the group were Nico Dettman, ESA Space Transportation Department director Bernardo Patti, ESA International Space Station Operations manager and Philippe Deloo, ESA European Service Module Study manager. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

Cost considerations in database selection - A comparison of DIALOG and ESA/IRS

NASA Technical Reports Server (NTRS)

Jack, R. F.

1984-01-01

It is pointed out that there are many factors which affect the decision-making process in determining which databases should be selected for conducting the online search on a given topic. In many cases, however, the major consideration will be related to cost. The present investigation is concerned with a comparison of the costs involved in making use of DIALOG and the European Space Agency's Information Retrieval Service (ESA/IRS). The two services are very comparable in many respects. Attention is given to pricing structure, telecommunications, the number of databases, prints, time requirements, a table listing online costs for DIALOG and ESA/IRS, and differences in mounting databases. It is found that ESA/IRS is competitively priced when compared to DIALOG, and, despite occasionally higher telecommunications costs, may be even more economical to use in some cases.

NEO follow-up, recovery and precovery campaigns at the ESA NEO Coordination Centre

NASA Astrophysics Data System (ADS)

Micheli, Marco; Koschny, Detlef; Drolshagen, Gerhard; Perozzi, Ettore; Borgia, Barbara

2016-01-01

The NEO Coordination Centre (NEOCC) has been established within the framework of the ESA Space Situational Awareness (SSA) Programme. Among its tasks are the coordination of observational activities and the distribution of up-to-date information on NEOs through its web portal. The Centre is directly involved in observational campaigns with various telescopes, including ESO's VLT and ESA's OGS telescope. We are also developing a network of collaborating observatories, with a variety of capabilities, which are alerted when an important observational opportunity arises. From a service perspective, the system hosted at the NEOCC collects information on NEOs produced by European services and makes it available to users, with a focus on objects with possible collisions with the Earth. Among the tools provided via our portal are the Risk List of all known NEOs with impact solutions, and the Priority List, which allows observers to identify NEOs in most urgent need of observations.

Erythropoiesis-stimulating agents for anaemia in adults with chronic kidney disease: a network meta-analysis.

PubMed

Palmer, Suetonia C; Saglimbene, Valeria; Mavridis, Dimitris; Salanti, Georgia; Craig, Jonathan C; Tonelli, Marcello; Wiebe, Natasha; Strippoli, Giovanni F M

2014-12-08

Several erythropoiesis-stimulating agents (ESAs) are available for treating anaemia in people with chronic kidney disease (CKD). Their relative efficacy (preventing blood transfusions and reducing fatigue and breathlessness) and safety (mortality and cardiovascular events) are unclear due to the limited power of head-to-head studies. To compare the efficacy and safety of ESAs (epoetin alfa, epoetin beta, darbepoetin alfa, or methoxy polyethylene glycol-epoetin beta, and biosimilar ESAs, against each other, placebo, or no treatment) to treat anaemia in adults with CKD. We searched the Cochrane Renal Group's Specialised Register to 11 February 2014 through contact with the Trials' Search Co-ordinator using search terms relevant to this review. Randomised controlled trials (RCTs) that included a comparison of an ESA (epoetin alfa, epoetin beta, darbepoetin alfa, methoxy polyethylene glycol-epoetin beta, or biosimilar ESA) with another ESA, placebo or no treatment in adults with CKD and that reported prespecified patient-relevant outcomes were considered for inclusion. Two independent authors screened the search results and extracted data. Data synthesis was performed by random-effects pairwise meta-analysis and network meta-analysis. We assessed for heterogeneity and inconsistency within meta-analyses using standard techniques and planned subgroup and meta-regression to explore for sources of heterogeneity or inconsistency. We assessed our confidence in treatment estimates for the primary outcomes within network meta-analysis (preventing blood transfusions and all-cause mortality) according to adapted GRADE methodology as very low, low, moderate, or high. We identified 56 eligible studies involving 15,596 adults with CKD. Risks of bias in the included studies was generally high or unclear for more than half of studies in all of the risk of bias domains we assessed; no study was low risk for allocation concealment, blinding of outcome assessment and attrition from follow-up. In network analyses, there was moderate to low confidence that epoetin alfa (OR 0.18, 95% CI 0.05 to 0.59), epoetin beta (OR 0.09, 95% CI 0.02 to 0.38), darbepoetin alfa (OR 0.17, 95% CI 0.05 to 0.57), and methoxy polyethylene glycol-epoetin beta (OR 0.15, 95% CI 0.03 to 0.70) prevented blood transfusions compared to placebo. In very low quality evidence, biosimilar ESA therapy was possibly no better than placebo for preventing blood transfusions (OR 0.27, 95% CI 0.05 to 1.47) with considerable imprecision in estimated effects. We could not discern whether all ESAs were similar or different in their effects on preventing blood transfusions and our confidence in the comparative effectiveness of different ESAs was generally very low. Similarly, the comparative effects of ESAs compared with another ESA, placebo or no treatment on all-cause mortality were imprecise.All proprietary ESAs increased the odds of hypertension compared to placebo (epoetin alfa OR 2.31, 95% CI 1.27 to 4.23; epoetin beta OR 2.57, 95% CI 1.23 to 5.39; darbepoetin alfa OR 1.83, 95% CI 1.05 to 3.21; methoxy polyethylene glycol-epoetin beta OR 1.96, 95% CI 0.98 to 3.92), while the effect of biosimilar ESAs on developing hypertension was less certain (OR 1.18, 95% CI 0.47 to 2.99). Our confidence in the comparative effects of ESAs on hypertension was low due to considerable imprecision in treatment estimates. The comparative effects of all ESAs on cardiovascular mortality, myocardial infarction (MI), stroke, and vascular access thrombosis were uncertain and network analyses for major cardiovascular events, end-stage kidney disease (ESKD), fatigue and breathlessness were not possible. Effects of ESAs on fatigue were described heterogeneously in the available studies in ways that were not useable for analyses. In the CKD setting, there is currently insufficient evidence to suggest the superiority of any ESA formulation based on available safety and efficacy data. Directly comparative data for the effectiveness of different ESA formulations based on patient-centred outcomes (such as quality of life, fatigue, and functional status) are sparse and poorly reported and current research studies are unable to inform care. All proprietary ESAs (epoetin alfa, epoetin beta, darbepoetin alfa, and methoxy polyethylene glycol-epoetin beta) prevent blood transfusions but information for biosimilar ESAs is less conclusive. Comparative treatment effects of different ESA formulations on other patient-important outcomes such as survival, MI, stroke, breathlessness and fatigue are very uncertain.For consumers, clinicians and funders, considerations such as drug cost and availability and preferences for dosing frequency might be considered as the basis for individualising anaemia care due to lack of data for comparative differences in clinical benefits and harms.

Physicochemical interactions among α-eleostearic acid-loaded liposomes applied to the development of drug delivery systems

NASA Astrophysics Data System (ADS)

Nogueira, Alessandro Oliveira de Moraes; de Sousa, Robson Simplício; Pereira, Luiza Silveira; Mallmann, Christian; da Silva Ferreira, Ailton; Clementin, Rosilene Maria; de Lima, Vânia Rodrigues

2018-02-01

In this study, α-eleostearic acid-loaded (α-ESA-loaded) dimyristoylphosphatidylcholine (DMPC) liposomes had their physicochemical properties characterized by horizontal attenuated total reflectance Fourier transform infrared (HATR-FTIR) spectroscopy, nuclear magnetic resonance (NMR) and differential scanning calorimetry (DSC). In vitro thiobarbituric acid reactive substance (TBARS) assays were performed to obtain preliminary information on the oxidative potential of the system. An α-ESA-promoted ordering effect in the lipid phosphate region was observed. It was associated with a rotation restriction due to an increase in the amount of lipid group hydrogen bonds. The fatty acid was responsible for the reduction in the degree of hydration of carbonyl groups located in the interfacial region of lipids. α-ESA disordered the DMPC methylene acyl chains by trans-gauche isomerization and increased its rotation rate. TBARS results showed pro-oxidant behavior on liposomes, induced by α-ESA. The discussion about the responses considered the degree of saturation of phosphatidylcholines and suggested that the α-ESA oxidative effects may be modulated by the liposome lipid composition. The versatility of liposomal carriers may be promising for the development of efficacious α-ESA-based drug delivery systems. Results described in this study contribute to the selection of adequate material to produce them.

Ecological approach to resource survey and planning for environmentally significant Areas: The ABC method

NASA Astrophysics Data System (ADS)

Bastedo, Jamie D.; Nelson, J. Gordon; Theberge, John B.

1984-03-01

A resource survey and planning method for parks, reserves, and other environmentally significant areas (ESAs) is presented in the context of a holistic balanced approach to land use and environmental management. This method provides a framework for the acquisition, analysis, presentation, and application of diverse ecological data pertinent to land use planning and resource management within ESAs. Through the independent analysis and subsequent integration of abiotic, biotic, and cultural or ABC information, land areas within an ESA are identified in terms of their relative environmental significance and environmental constraints. The former term encompasses wildlife, historic, and other resource values, while the latter term reflects biophysical hazards and sensitivities, and land use conflicts. The method thus calls for a matching of an ESA's distinctive attributes with appropriate land use and institutional arrancements through an analysis of available acts, regulations, agencies, and other conservation and land use management mechanisms. The method culminates with a management proposal showing proposed park or reserve allocations, buffer areas, or other land use controls aimed at preserving an ESA's special ecological qualities, while providing for resource development. The authors suggest that all resource management decisions affecting ESA's should be governed by a philosophical stance that recognizes a spectrum of broad land use types, ranging from preservation to extractive use and rehabilitation.

Proceedings of the Spacecraft Charging Technology Conference Held in Monterey, California on 31 October - 3 November 1989. Volume 1

DTIC Science & Technology

1989-11-01

Technical Note I (Chapter 4), ESA Contract 8011 /88. IASB, 1989. Williams, D..., E. Keppler, T.A. Fritz, B. Wilken and G. Wibberenz, The ISEE 1 and 2...particles’ range in aluminium as calculated by the SHIELDOSE program: this shows that higher energy particles can penetrate appreciable distances before...described here is limited to the study of a shadowed or partially illuminated kapton patch on a sunlit, conducting aluminium spacecraft structure. The

ESA activities on satellite laser ranging to non-cooperative objects

NASA Astrophysics Data System (ADS)

Flohrer, Tim; Krag, Holger; Funke, Quirin; Jilete, Beatriz; Mancas, Alexandru

2016-07-01

Satellite laser ranging (SLR) to non-cooperative objects is an emerging technology that can contribute significantly to operational, modelling and mitigation needs set by the space debris population. ESA is conducting various research and development activities in SLR to non-cooperative objects. ESA's Space Situational Awareness (SSA) program supports specific activities in the Space Surveillance and Tracking (SST) segment. Research and development activities with operational aspects are run by ESA's Space Debris Office. At ESA SSA/SST comprises detecting, cataloguing and predicting the objects orbiting the Earth, and the derived applications. SST aims at facilitating research and development of sensor and data processing technologies and of related common components while staying complementary with, and in support of, national and multi-national European initiatives. SST promotes standardisation and interoperability of the technology developments. For SLR these goals are implemented through researching, developing, and deploying an expert centre. This centre shall coordinate the contribution of system-external loosely connected SLR sensors, and shall provide back calibration and expert evaluation support to the sensors. The Space Debris Office at ESA is responsible for all aspects related to space debris in the Agency. It is in charge of providing operational support to ESA and third party missions. Currently, the office studies the potential benefits of laser ranging to space debris objects to resolve close approaches to active satellites, to improve re-entry predictions of time and locations, and the more general SLR support during contingency situations. The office studies the determination of attitude and attitude motion of uncooperative objects with special focus on the combination of SLR, light-curve, and radar imaging data. Generating sufficiently precise information to allow for the acquisition of debris objects by a SLR sensor in a stare-and-chase scenario, or from externally provided orbital information, is also investigated. In our paper we will outline the motivation and objectives, as well as detail the current status of the various and parallel SLR-related SST and Space Debris Office activities at ESA. We will provide an overview on plans for SLR activities in research and development and in operational support. Current gaps in the standardisation of data exchange and sensor interfaces will be addressed, reflecting the need of coordinating multiple stations in all tasks.

Second space Christmas for ESA: Huygens to begin its final journey to Titan/ Media activities.

NASA Astrophysics Data System (ADS)

2004-12-01

At 1.25 billion km from Earth, after a 7-year journey through the Solar system, ESA’s Huygens probe is about to separate from the Cassini orbiter to enter a ballistic trajectory toward Titan, the largest and most mysterious moon of Saturn, in order to dive into its atmosphere on 14 January. This will be the first man-made object to explore in-situ this unique environment, whose chemistry is assumed to be very similar to that of the early Earth just before life began, 3.8 billion years ago. The Cassini-Huygens pair, a joint mission conducted by NASA, ESA and the Italian space agency (ASI), was launched into space on 15 October 1997. With the help of several gravity assist manoeuvres during flybys of Venus, Earth and Jupiter, it took almost 7 years for the spacecraft to reach Saturn. The Cassini orbiter, carrying Huygens on its flank, entered an orbit around Saturn on 1 July 2004, and began to investigate the ringed planet and its moons for a mission that will last at least four years. The first distant flyby of Titan took place on 2-3 July 2004. It provided data on Titan's atmosphere which were confirmed by the data obtained during the first close flyby on 26 October 2004 at an altitude of 1174 km. These data were used to validate the entry conditions of the Huygens probe. A second close flyby of Titan by Cassini-Huygens at an altitude of 1200 km is scheduled on 13 December and will provide additional data to further validate the entry conditions of the Huygens probe. On 17 December the orbiter will be placed on a controlled collision course with Titan in order to release Huygens on the proper trajectory, and on 21 December (some dates and times are subject to minor adjustment for operational reasons, except the entry time on 14 January which is know to within an accuracy of under 2 minutes) all systems will be set up for separation and the Huygens timers will be set to wake the probe a few hours before its arrival at Titan. The Huygens probe is due to separate on the morning of 25 December at about 05:08 CET. Since the Cassini orbiter will have to achieve precise pointing for the release, there will be no real-time telemetry available until it turns back its main antenna toward Earth and beams the recorded data of the release. It will take over an hour (67 min) for the signals to reach us on Earth. The final data confirming the separation will be available later on Christmas Day. After release, Huygens will move away from Cassini at a speed of about 35 cm per second and, to keep on track, will spin on its axis, making about 7 revolutions a minute. Huygens will not communicate with Cassini for the whole period until after deployment of the main parachute following entry into Titan’s atmosphere. On 28 December Cassini will then manoeuvre off collision course to resume its mission and prepare itself to receive Huygens data, which it will record for later playback to Earth. Huygens will remain dormant until a few hours before its arrival at Titan on 14 January. The entry into the atmosphere is set for 11:15 CET. Huygens is planned to complete its descent in about two hours and 15 minutes, beaming back its science data to the Cassini orbiter for replay to Earth later in the afternoon. If Huygens, which is designed as an atmospheric probe rather than a lander, survives touchdown on the surface, it could deliver up to 2 hours of bonus data before the link with Cassini is lost. Direct radio signals from Huygens will reach Earth after 67 minutes of interplanetary travel at the speed of light. An experiment has been set up by radio scientists that will use an array of radio telescopes around the Pacific to attempt to detect a faint tone from Huygens. If successful, early detection is not expected before around 11:30 CET. The European Space Agency owns and manages the Huygens probe and is in charge of operations of the probe from its control centre in Darmstadt, Germany. NASA's Jet Propulsion Laboratory in Pasadena, California, designed, developed and assembled the Cassini orbiter. NASA's Deep Space Network, also managed by JPL, will be providing communications support via the Cassini orbiter and relaying it to ESA’s control centre in Darmstadt for processing. The Italian Space Agency provided the high-gain antenna on the Cassini orbiter, much of the radio system and elements of several of Cassini's science instruments. The Huygens payload has been provided by teams including from CNES, DLR, ASI and PPARC, and outside Europe, from NASA. Practical arrangements for the Media wishing to cover the event These dramatic events marking the first attempt ever to unveil the mysteries of Titan in-situ, a distant world bigger than Mercury and Pluto which may hold clues to the early days of our own planet, will be marked by several media activities not to be missed. Pencil them into your diary. Saturday 25 December Spacecraft operations will be run at NASA’s Jet Propulsion Laboratory (JPL) in Pasadena, California. The ESA Media Relations Office in Paris will be operational from 04:00 hrs to 12:00 CET. ESA specialists can be reached for interviews and comments via the ESA News Desk on +33(0)1.53.69.71.55. Contacts: Franco Bonacina, Anne-Marie Rémondin, Roberto Lo Verde. Interviews from JPL can also be arranged by calling the JPL media relations office at + 1. 818-354-5011. ESA specialists at JPL: Jean-Pierre Lebreton, Claudio Sollazzo. 05:08 CET - Expected separation of the Huygens probe from the Cassini orbiter ~07:00 CET - Status report upon successful separation from NASA/JPL 10:00 CET at the latest : ESA press release assessing the separation of the Huygens probe ~10:00 CET - ESA TV Video News Release produced at JPL during separation (contact for TVs: Claus Habfast: + 31(0)6.51.18.14.96, claus.habfast@esa.int) Transmission details will be on http://television.esa.int 12:00 CET - Replay of ESA TV Video News Release on separation Thursday 13 January ESA’s ESOC establishment in Darmstadt, Germany, will act as the main European press centre. The Huygens Principal Investigators, the ESA Huygens Mission Manager and Project Scientist will be at ESA/ESOC and available for interviews. If you wish to attend the media activities at ESOC, please return the attached accreditation form. Press Contacts: Jocelyne Landeau-Constantin jocelyne.landeau-constantin@esa.int (+49(0)6151.90.2696) Bernhard von Weyhe Bernhard.von.Weyhe@esa.int (+49(0)6151.90.2516). 17:00-17:30 CET - Press briefing at ESA/ESOC Control Centre. Televised on ESA TV - This event can also be followed remotely by phone : +49(0)69.4035.9681. Friday 14 January Media briefings originated at ESA/ESOC will also be retransmitted to several ESA establishments and across Europe: Cité des Sciences/ La Villette in Paris (F), (event hosted in coordination with ESA and CNES), ESA/ESTEC in Noordwijk (NL), ESA/ESRIN Frascati (I), ESA/ESAC in Villafranca (E), Central London (event hosted by PPARC). ESA specialists will be on hand at the various locations for interviews. If you wish to attend the briefings at one of these venues, please contact the local Communication services directly. ESA for Cité des Sciences, Paris (F): Anne-Marie Rémondin (Anne-Marie.Remondin@esa.int), + 33(0)1.5369.7155 or Brigitte Kolmsee (Brigitte.Kolmsee@esa.int), + 33(0)1.5369.7299 ESA/ESTEC,Noorwijk Space Expo (NL): + 31(0)71.565.3006- Wil Spangenberg (Wil.Spangenberg@esa.int) ESA/ESRIN, Frascati (I): + 39 06 9418 0951- Franca Morgia (Franca.Morgia@esa.int) ESA/ESAC, Villafranca (E): + 34 91 813 11 00- Monica Oerke (Monica.Oerke@esa.int) PPARC, London (UK) : Peter Barratt + 44 (0)1793 44 20 25 (Peter.Barratt@pparc.ac.uk) ESA TV Broadcast schedule for 14 January 2005 09:00-09:30 CET - ESA TV broadcast - Cassini turns to Huygens - Feeds from ESA/ESOC main Control Room 11:00-12:15 CET - ESA TV Broadcast - Probe activation to parachute deployment and status of tracking by radio-telescope 13:30-14:00 CET - Press briefing at ESA/ESOC: Huygens descent update (possible results from ground radio telescope observations - televised on ESA TV 14:30-15:00 CET - ESA TV broadcast: mission update 16:00-16:30 CET - ESA TV broadcast: mission update As of 17:15 CET - Press briefing: arrival of first data - televised on ESA TV 23:00-24:00 CET - Press briefing: presentation of first image if available) - Televised on ESA TV All events can also be followed (audio only) by calling + 49(0)69.4035.9681 and highlights of ESA TV can be watched on the Web at http://saturn.esa.int Saturday 15 January 11:00-12:00 CET - Press conference at ESA/ESOC: presentation of the first image, sounds, etc. - not broadcast live on ESA TV. This event can also be followed (audio only) by calling + 49(0)69.4035.9681. A video news release with the highlights will be available on ESA TV for broadcasters immediately at the end of the press conference. Satellite details for ESA TV broadcast reception: The ESA TV Service provides live broadcasts of ESA’s most important events on the Astra 2-C satellite, using a digital transponder that enables everyone in the satellite’s footprint, with a digital receiver and a parabolic pointing at 19.2 degrees East, to follow these events. For more information and updates, please check the ESA TV Website: http://television.esa.int . And on the Web You can follow all main Cassini/Huygens mission events on the ESA web at: http://saturn.esa.int Here you will find information on Cassini-Huygens and its status, a rich selection of multimedia material, news on the separation of Huygens from the Cassini orbiter and the latest updates on January 13. There will be continuous coverage during the last exciting hours of the descent on 14 January, with the first image expected late on 14 January or on 15 January. Bookmark now http://saturn.esa.int ! And if you have not already done so, subscribe to the ESA portal news at http://www.esa.int/esaCP/subscribers.html , you will get the latest news on this fascinating mission directly into your mail box! Messages from earthlings and pop music heading to Titan Before the mission was launched, ESA offered Europeans a unique opportunity to send a message to the unknown. Over 80 000 people wanted to share the excitement of this mission and wrote or drew a message that was engraved on a CD-ROM put on board the Huygens probe. The messages can be seen on http://television.esa.int/Huygens/index.cfm The same CD ROM carries four pop songs, composed by French musicians Julien Civange and Louis Haéri. More about this project at http://www.music2titan.com Specific information for media representatives going to ESA/ESOC Getting there: The nearest airport is Frankfurt-am-Main and it takes about 20 minutes by taxi to get to ESA/ESOC. A shuttle bus is also available from the airport approximately every 30 minutes. There are also frequent trains (approx. every 40 minutes) from the airport to Darmstadt (one change). http://www.heag.de/verkehr/02_02.html http://www.bahn.de/pv/view/index.shtml Accommodation: Darmstadt has many hotels, ranging in price from € 68 to € 230 (the closest to ESA/ESOC is a 4-star Maritim Konferenz Hotel, in walking distance from the Control Centre). For further information about Darmstadt hotels go to http://www.proregio-darmstadt.de/uebernachten/hotel.asp. If you need help with accommodation, do not hesitate to contact the ESA/ESOC travel office on +49(0)6151.902.885. Laptops/ Internet/ Cell Phones: Power supply rating: 220-240 volts (adaptor plug available in most hardware stores or at most international airport shops). Most North American cell phones will not work in Europe unless they are tri-band phones. Internet via LAN: Standard network connector RJ45 required in laptop. Internet via analogue modem: Standard RJ11 connector in laptop, special German Telekom TAE connection to the socket. Internet via ISDN: PCMCIA Card inside Laptop, RJ45 in the wall. The ESA/ESOC Press Rooms are equipped with ISDN and standard network with RJ45 cable. No wireless LAN is available for the media. Analog lines can be provided if needed.

Evolution of ESA's SSA Conjunction Prediction Service

NASA Astrophysics Data System (ADS)

Escobar, D.; Sancho, A. Tirado, J.; Agueda, A.; Martin, L.; Luque, F.; Fletcher, E.; Navarro, V.

2013-08-01

This paper presents the recent evolution of ESA's SSA Conjunction Prediction Service (CPS) as a result of an on-going activity in the Space Surveillance and Tracking (SST) Segment of ESA's Space Situational Awareness (SSA) Programme. The CPS is one of a number of precursor services being developed as part of the SST segment. It has been implemented as a service to provide external users with web-based access to conjunction information and designed with a service-oriented architecture. The paper encompasses the following topics: service functionality enhancements, integration with a live objects catalogue, all vs. all analyses supporting an operational concept based on low and high fidelity screenings, and finally conjunction detection and probability algorithms.

East Meets West on "Double Star", a Joint Mission to Explore Earth's Magnetic Field

NASA Astrophysics Data System (ADS)

2001-07-01

ESA Director General Antonio Rodotà and Luan Enjie, Administrator of the CNSA, signed an official agreement that will enable European experiments to be flown on Chinese satellites for the first time. "This agreement marks a significant advance for international cooperation in the exploration and peaceful use of outer space," said Mr. Rodotà. "It is one of the most important landmarks in scientific collaboration since ESA and the People's Republic of China first agreed to exchange scientific information more than 20 years ago." "The Double Star programme will be just the first step in substantial cooperation between the Chinese National Space Administration and ESA" said Mr Luan Enjie. "The signing of today's agreement paves the way not only for reciprocal cooperation between scientists, but for the establishment of comprehensive cooperation between the two agencies". Double Star will follow in the footsteps of ESA's groundbreaking Cluster mission by studying the effects of the Sun on the Earth's environment. Conducting joint studies with Cluster and Double Star should increase the overall scientific return from both missions. A key aspect of ESA's participation in the Double Star project is the inclusion of 10 instruments that are identical to those currently flying on the four Cluster spacecraft. A further eight experiments will be provided by Chinese institutes. "We hope it will be possible to make coordinated measurements with both Cluster and Double Star." said Cluster Project Scientist Philippe Escoubet. "For example, we would hope to carry out a joint exploration of the magnetotail, a region where storms of high energy particles are generated. When these particles reach Earth, they can cause power cuts, damage satellites and disrupt communications." Six of the eleven Cluster principal investigators have agreed to provide flight spares or duplicates of the experiments that are currently revolutionising our understanding of near-Earth space. This reuse of Cluster instruments has a number of advantages for both European and Chinese scientists. "By flying experiments identical to those on Cluster, we can reduce costs and development time," explained Alberto Gianolio, ESA Project Manager for Double Star. "This will minimise risk and help us to ensure that we are able to meet the spacecraft development schedule." ESA has agreed to contribute 8 million euros to the Double Star programme. This funding will be used for refurbishment and pre-integration of the European instruments, acquisition of data for 4 hours per day and coordination of scientific operations. Notes for Editors: Double Star will be the first mission launched by China to explore the Earth's magnetosphere - the magnetic bubble that surrounds our planet. As its name suggests, Double Star will involve two satellites - each designed, developed, launched and operated by the CNSA - flying in complementary orbits around the Earth. This orbital configuration will enable scientists to obtain simultaneous data on the changing magnetic field and population of electrified particles in different regions of the magnetosphere. The duo is expected to be launched by Chinese Long March 2C rockets in December 2002 and March 2003. This schedule may enable them to operate alongside ESA's Cluster mission - a mini-flotilla of four identical spacecraft launched into elliptical orbits around the Earth last summer. The "equatorial" spacecraft (DSP-1) will be launched into an elliptical orbit of 550 x 60,000 km, inclined at 28.5 degrees to the equator. This will enable it to investigate the Earth's huge magnetic tail, the region where particles are accelerated towards the planet's magnetic poles by a process known as reconnection. The "polar" satellite (DSP-2) will concentrate on physical processes taking place over the magnetic poles and the development of aurorae. It will have a 350 x 25,000 km orbit taking it round the Earth once every 7.3 hours.

Hydrogeology and water quality of the Pepacton Reservoir Watershed in southeastern New York. Part 1. Concentrations of pesticides and their degradates in stream baseflow, 2000-2001

USGS Publications Warehouse

Phillips, Patrick J.; Heisig, Paul M.

2004-01-01

Baseflow samples were collected from 20 small streams in the Pepacton Reservoir watershed in Delaware County, N.Y., from December 2000 through November 2001 as part of an investigation to define the occurrence of pesticides in shallow ground water in watersheds containing either a recent (2001) corn crop, a previous (1993-94) corn crop, or no history of row-crop cultivation. Baseflow water quality was assumed to represent the chemical quality of shallow ground water within the drainage area above each sampling site.Baseflow samples were analyzed for 57 pesticides and pesticide degradates. Three herbicides (atrazine, metolachlor and simazine) and three herbicide degradates (alachlor ESA [ethanesulfonic acid], deethylatrazine, and metolachlor ESA) were detected, but no concentrations exceeded any Federal or State water-quality criteria, and the maximum concentrations of all compounds except metolachlor ESA were less than 0.10 microgram per liter. The most frequently detected compounds (atrazine, metolachlor, deethylatrazine and metolachlor ESA) are either those typically used on corn crops, or those whose parent compounds are commonly used on corn crops and have been detected in streams that drain row-crop settings elsewhere in New York State. The pesticide and pesticide-degradate concentrations in baseflow samples collected in December 2000 and July 2001 samples generally corresponded to the amount of cornfield acreage in each watershed in 2001.The types of pesticides detected, and their median concentrations, were similar to those noted in two previous ground-water studies in row-crop areas elsewhere in upstate New York. Also the SAM ratios (ratio of metolachlor ESA concentration to metolachlor concentration) for the Pepacton samples were similar to those for ground-water samples from other agricultural settings in upstate New York, but were significantly higher than that for stormflow and baseflow samples collected in 1997-98 from Canajoharie Creek, an upstate stream that drains row-crop farmland. These comparisons confirm that the baseflow samples were derived from, and were representative of, ground water in their respective watersheds. Late-summer decreases in atrazine and deethylatrazine concentrations at a site where corn was grown in 2001 may have resulted from the seasonally dry conditions and the accompanying decrease in ground-water discharge from the upper-most part of the surficial aquifer system to streams. The lack of a similar decrease in metolachlor ESA concentrations during this period may reflect the transport of metolachlor ESA to deeper parts of the surficial aquifer that continued to discharge to streams during the dry period.

FBIS report. Science and technology: Europe/International, March 29, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-03-29

;Partial Contents: Advanced Materials (EU Project to Improve Production in Metal Matrix Compounds Noted, Germany: Extremely Hard Carbon Coating Development, Italy: Director of CNR Metallic Materials Institute Interviewed); Aerospace (ESA Considers Delays, Reductions as Result of Budget Cuts, Italy: Space Agency`s Director on Restructuring, Future Plans); Automotive, Transportation (EU: Clean Diesel Engine Technology Research Reviewed); Biotechnology (Germany`s Problems, Successes in Biotechnology Discussed); Computers (EU Europort Parallel Computing Project Concluded, Italy: PQE 2000 Project on Massively Parallel Systems Viewed); Defense R&D (France: Future Tasks of `Brevel` Military Intelligence Drone Noted); Energy, Environment (German Scientist Tests Elimination of Phosphates); Advanced Manufacturing (France:more » Advanced Rapid Prototyping System Presented); Lasers, Sensors, Optics (France: Strategy of Cilas Laser Company Detailed); Microelectronics (France: Simulation Company to Develop Microelectronic Manufacturing Application); Nuclear R&D (France: Megajoule Laser Plan, Cooperation with Livermore Lab Noted); S&T Policy (EU Efforts to Aid Small Companies` Research Viewed); Telecommunications (France Telecom`s Way to Internet).« less

ESA's Earth Observation Programmes in the Changing Anthropocene

NASA Astrophysics Data System (ADS)

Liebig, Volker

2016-07-01

The intervention will present ESA's Earth Observation programmes and their relevance to studying the anthropocene. ESA's Earth observation missions are mainly grouped into three categories: The Sentinel satellites in the context of the European Copernicus Programme, the scientific Earth Explorers and the meteorological missions. Developments, applications and scientific results for the different mission types will be addressed, along with overall trends and strategies. The Earth Explorers, who form the science and research element of ESA's Living Planet Programme, focus on the atmosphere, biosphere, hydrosphere, cryosphere and Earth's interior. The Earth Explorers also aim at learning more about the interactions between these components and the impact that human activity is having on natural Earth processes. The Sentinel missions provide accurate, timely, long term and uninterrupted data to provide key information services, improving the way the environment is managed, and helping to mitigate the effects of climate change. The operational Sentinel satellites can also be exploited for scientific studies of the anthropocene. In the anthropocene human activities affect the whole planet and space is a very efficient means to measure their impact, but for relevant endeavours to be successful they can only be carried out in international cooperation. ESA maintains long-standing partnerships with other space agencies and institutions worldwide. In running its Earth observation programmes, ESA responds to societal needs and challenges and to requirements resulting from political priorities set by decision makers. Activities related to Climate Change are a prime example. Within ESA's Climate Change Initiative, 13 Essential Climate Variables are constantly monitored to create a long-term record of key geophysical parameters.

The ESA scientific exploitation element results and outlook

NASA Astrophysics Data System (ADS)

Desnos, Yves-louis; Regner, Peter; Delwart, Steven; Benveniste, Jerome; Engdahl, Marcus; Donlon, Craig; Mathieu, Pierre-Philippe; Fernandez, Diego; Gascon, Ferran; Zehner, Claus; Davidson, Malcolm; Goryl, Philippe; Koetz, Benjamin; Pinnock, Simon

2017-04-01

The Scientific Exploitation of Operational Missions (SEOM) element of ESA's fourth Earth Observation Envelope Programme (EOEP4) prime objective is to federate, support and expand the international research community built up over the last 25 years exploiting ESA's EO missions. SEOM enables the science community to address new scientific research areas that are opened by the free and open access to data from operational EO missions. Based on community-wide recommendations, gathered through a series of international thematic workshops and scientific user consultation meetings, key research studies have been launched over the last years to further exploit data from the Sentinels (http://seom.esa.int/). During 2016 several Science users consultation workshops have been organized, new results from scientific studies have been published and open-source multi-mission scientific toolboxes have been distributed (SNAP 80000 users from 190 countries). In addition the first ESA Massive Open Online Courses on Climate from space have been deployed (20000 participants) and the second EO Open Science conference was organized at ESA in September 2016 bringing together young EO scientists and data scientists. The new EOEP5 Exploitation element approved in 2016 and starting in 2017 is taking stock of all precursor activities in EO Open Science and Innovation and in particular a workplan for ESA scientific exploitation activities has been presented to Member States taking full benefit of the latest information and communication technology. The results and highlights from current scientific exploitation activities will be presented and an outlook on the upcoming activities under the new EOEP5 exploitation element will be given.

Strengthening the management of ESA - the Inter-Directorate Reform of Corporate and Risk Management

NASA Astrophysics Data System (ADS)

Feustel-Büechl, Jörg; Arend, Harald; Derio, Eric; Infante, Giovanni; Kreiner, Gerhard; Phaler, Jesse; Tabbert, Michael

2007-02-01

ESA has undertaken the Inter-Directorate Reform of Corporate and Risk Management to strengthen the Agency's internal operations. The reform was completed at the end of 2006, encompassing five dedicated projects on Risk Management, Agency-Wide Controlling System, Project Plan and Integrated Project Review, General Budget Structure and Charging Policy, and Corporate Information Systems. It has contributed to improved management of the Agency's internal operations by engaging all internal stakeholders in a common objective, introducing improvements to planning and management methods, elaborating consolidated information structures and tools, contributing to enhanced transparency and accountability, and by providing qualified new policies, processes and tools.

Exploiting Orbital Data and Observation Campaigns to Improve Space Debris Models

NASA Astrophysics Data System (ADS)

Braun, V.; Horstmann, A.; Reihs, B.; Lemmens, S.; Merz, K.; Krag, H.

The European Space Agency (ESA) has been developing the Meteoroid and Space Debris Terrestrial Environment Reference (MASTER) software as the European reference model for space debris for more than 25 years. It is an event-based simulation of all known individual debris-generating events since 1957, including breakups, solid rocket motor firings and nuclear reactor core ejections. In 2014, the upgraded Debris Risk Assessment and Mitigation Analysis (DRAMA) tool suite was released. In the same year an ESA instruction made the standard ISO 24113:2011 on space debris mitigation requirements, adopted via the European Cooperation for Space Standardization (ECSS), applicable to all ESA missions. In order to verify the compliance of a space mission with those requirements, the DRAMA software is used to assess collision avoidance statistics, estimate the remaining orbital lifetime and evaluate the on-ground risk for controlled and uncontrolled reentries. In this paper, the approach to validate the MASTER and DRAMA tools is outlined. For objects larger than 1 cm, thus potentially being observable from ground, the MASTER model has been validated through dedicated observation campaigns. Recent campaign results shall be discussed. Moreover, catalogue data from the Space Surveillance Network (SSN) has been used to correlate the larger objects. In DRAMA, the assessment of collision avoidance statistics is based on orbit uncertainty information derived from Conjunction Data Messages (CDM) provided by the Joint Space Operations Center (JSpOC). They were collected for more than 20 ESA spacecraft in the recent years. The way this information is going to be used in a future DRAMA version is outlined and the comparison of estimated manoeuvre rates with real manoeuvres from the operations of ESA spacecraft is shown.

Venus within ESA probe reach

NASA Astrophysics Data System (ADS)

2006-03-01

Venus Express mission controllers at the ESA Space Operations Centre (ESOC) in Darmstadt, Germany are making intensive preparations for orbit insertion. This comprises a series of telecommands, engine burns and manoeuvres designed to slow the spacecraft down from a velocity of 29000 km per hour relative to Venus, just before the first burn, to an entry velocity some 15% slower, allowing the probe to be captured into orbit around the planet. The spacecraft will have to ignite its main engine for 50 minutes in order to achieve deceleration and place itself into a highly elliptical orbit around the planet. Most of its 570 kg of onboard propellant will be used for this manoeuvre. The spacecraft’s solar arrays will be positioned so as to reduce the possibility of excessive mechanical load during engine ignition. Over the subsequent days, a series of additional burns will be done to lower the orbit apocentre and to control the pericentre. The aim is to end up in a 24-hour orbit around Venus early in May. The Venus orbit injection operations can be followed live at ESA establishments, with ESOC acting as focal point of interest (see attached programme). In all establishments, ESA specialists will be on hand for interviews. ESA TV will cover this event live from ESOC in Darmstadt. The live transmission will be carried free-to-air. For broadcasters, complete details of the various satellite feeds are listed at http://television.esa.int. The event will be covered on the web at venus.esa.int. The website will feature regular updates, including video coverage of the press conference and podcast from the control room at ESA’s Operations Centre. Media representatives wishing to follow the event at one of the ESA establishments listed below are requested to fill in the attached registration form and fax it back to the place of their choice. For further information, please contact: ESA Media Relations Division Tel : +33(0)1.53.69.7155 Fax: +33(0)1.53.69.7690 Venus Express Orbit Insertion - Tuesday 11 April 2006 ESA/ESOC, Robert Bosch Strasse, 5 - Darmstadt (Germany) PROGRAMME 07:30 - Doors open 08:45 - Start of local event, welcome addresses 09:10 - ESA TV live from Mission Control Room (MCR) starts 09:17 - Engine burn sequence starts 09:45 - Occultation of spacecraft by Venus starts 09:55 - Occultation ends 10:07 - Main engine burn ends 10:20 - Address by Jean-Jacques Dordain, ESA’s Director General, and other officials Break and buffet Interview opportunities 11:30-12:15 - Press Conference Jean-Jacques Dordain, Director General, ESA Prof. David Southwood, Director of Science, ESA Gaele Winters, Director of Operations and Infrastructure, ESA Manfred Warhaut, Flight Operations Director, ESA Håkan Svedhem, Venus Express Project Scientist, ESA Don McCoy, Venus Express Project Manager, ESA 13:15 - End of event at ESOC ACCREDITATION REQUEST FORM Venus Express Orbit Insertion - ESA/ESOC Darmstadt - 11 April 2006 First name:___________________ Surname:_____________________ Media:______________________________________________________ Address: ___________________________________________________ ____________________________________________________________ Tel:_______________________ Fax: ___________________________ Mobile :___________________ E-mail: ________________________ I will be attending the Venus Express Orbit Insertion event at the following site: [ ] Germany Location: ESA/ESOC Address: Robert Bosch Strasse 5, Darmstadt, Germany Opening hours: 07:30 - 13:00 Contact: Jocelyne Landeau-Constantin, Tel: +49.6151.902.696 - Fax: +49.6151.902.961 [ ] France Location: ESA HQ Address: 8/10, rue Mario Nikis - Paris 15, France Opening hours: 08:00 - 13:00 Contact: Anne-Marie Remondin - Tel: +33(0)1.53.69.7155 - fax: +33(0)1.53.69.7690 [ ] The Netherlands Location: Newton Room, ESA/ESTEC Address: Keplerlaan 1, Noordwijk, The Netherlands Opening hours: 08:30 - 12:30 Contact: Michel van Baal, tel. + 31 71 565 3006, fax + 31 71 565 5728 [ ] Italy Location: ESA/ESRIN Address: Via Galileo Galilei, Frascati (Rome), Italy Opening hours: 07:00 - 14:00 Contact: Franca Morgia - Tel: +39.06.9418.0951 - Fax: +39.06.9418.0952 [ ] Spain Location: ESA/ESAC Address: Urbanización Villafranca del Castillo, Villanueva de la Cañada, Madrid, Spain Opening hours: 8:30 - 13:30 Contact: Monica Oerke, Tel + 34 91 813 13 27/59 - Fax: + 34 91 813 12 19

Ultrafast electrical spectrum analyzer based on all-optical Fourier transform and temporal magnification.

PubMed

Duan, Yuhua; Chen, Liao; Zhou, Haidong; Zhou, Xi; Zhang, Chi; Zhang, Xinliang

2017-04-03

Real-time electrical spectrum analysis is of great significance for applications involving radio astronomy and electronic warfare, e.g. the dynamic spectrum monitoring of outer space signal, and the instantaneous capture of frequency from other electronic systems. However, conventional electrical spectrum analyzer (ESA) has limited operation speed and observation bandwidth due to the electronic bottleneck. Therefore, a variety of photonics-assisted methods have been extensively explored due to the bandwidth advantage of the optical domain. Alternatively, we proposed and experimentally demonstrated an ultrafast ESA based on all-optical Fourier transform and temporal magnification in this paper. The radio-frequency (RF) signal under test is temporally multiplexed to the spectrum of an ultrashort pulse, thus the frequency information is converted to the time axis. Moreover, since the bandwidth of this ultrashort pulse is far beyond that of the state-of-the-art photo-detector, a temporal magnification system is applied to stretch the time axis, and capture the RF spectrum with 1-GHz resolution. The observation bandwidth of this ultrafast ESA is over 20 GHz, limited by that of the electro-optic modulator. Since all the signal processing is in the optical domain, the acquisition frame rate can be as high as 50 MHz. This ultrafast ESA scheme can be further improved with better dispersive engineering, and is promising for some ultrafast spectral information acquisition applications.

Does access to clinical study reports from the European Medicines Agency reduce reporting biases? A systematic review and meta-analysis of randomized controlled trials on the effect of erythropoiesis-stimulating agents in cancer patients

PubMed Central

Grabik, Michael; Tonia, Thomy; Jüni, Peter; Pétavy, Frank; Pignatti, Francesco

2017-01-01

Since 2010, the European Medicines Agency (EMA) has provided access to clinical study reports (CSRs). We requested CSRs for randomized controlled trials (RCTs) of erythropoiesis-stimulating agents (ESAs) in cancer patients from EMA and identified RCT publications with literature searches. We assessed CSR availability and completeness, the impact of unreported and unpublished data obtained from CSRs on the effects of ESAs on quality of life (QoL) of cancer patients, and discrepancies between data reported in the public domain and in CSRs. We used random-effects meta-analyses to evaluate the effect of ESAs on QoL measured with Functional Assessment of Cancer Therapy-Anemia (FACT-An), FACT-Fatigue (FACT-F) and FACT-Anemia Total (FACT-An Total) stratified by data source and the impact of discrepancies on QoL, mortality, adverse events, and clinical effectiveness outcomes. We identified 94 eligible RCTs; CSRs or other study documentation were available for 17 (18%) RCTs at EMA. Median report length was 1,825 pages (range 72–14,569). Of 180 outcomes of interest reported in the EMA documentation, 127 (71%) were publicly available. For 80 of those (63%) we noted discrepancies, but these had little impact on the pooled effect estimates. Of 27 QoL outcomes reported in the CSRs, 17 (63%) were unpublished. Including six unpublished comparisons (pooled mean difference [MD] 0.20; 95% confidence interval [CI] -1.93, 2.33) reduced the pooled effect of ESAs for FACT-An from MD 5.51 (95% CI 4.20, 6.82) in published data to MD 3.21 (95% CI 1.38, 5.03), which is below a clinically important difference (defined as MD ≥4). Effects were similar for FACT-F and FACT-An Total. Access to CSRs from EMA reduced reporting biases for QoL outcomes. However, EMA received documentation for a fraction of all RCTs on effects of ESAs in cancer patients. Additional efforts by other agencies and institutions are needed to make CSRs universally available for all RCTs. PMID:29228059

Space Station - Risks and vision

NASA Technical Reports Server (NTRS)

Pedersen, K.

1986-01-01

In assessing the prospects of the NASA Space Station program, it is important to take account of the long term perspective embodied in the proposal; its international participants are seen as entering a complex web of developmental and operational interdependence of indefinite duration. It is noted to be rather unclear, however, to what extent this is contemplated by such potential partners as the ESA, which has its own program goals. These competing hopes for eventual autonomy in space station operations will have considerable economic, technological, and political consequences extending well into the next century.

ESA Earth Observation missions at the service of geoscience

NASA Astrophysics Data System (ADS)

Aschbacher, Josef

2017-04-01

The intervention will present ESA's Earth Observation programmes and their relevance to geoscience. ESA's Earth observation missions are mainly grouped into three categories: The Sentinel satellites in the context of the European Copernicus Programme, the scientific Earth Explorers and the meteorological missions. Developments, applications and scientific results for the different mission types will be addressed, along with overall trends and boundary conditions. The Earth Explorers, who form the science and research element of ESA's Living Planet Programme, focus on the atmosphere, biosphere, hydrosphere, cryosphere and Earth's interior. The Earth Explorers also aim at learning more about the interactions between these components and the impact that human activity is having on natural Earth processes. The Sentinel missions provide accurate, timely, long term and uninterrupted data to provide key information services, improving the way the environment is managed, and helping to mitigate the effects of climate change. The operational Sentinel satellites can also be exploited for scientific endeavours. Meteorological satellites help to predict the weather and feature the most mature application of Earth observation. Over the last four decades satellites have been radically improving the accuracy of weather forecasts by providing unique and indispensable input data to numerical computation models. In addition, Essential Climate Variables (ECV) are constantly monitored within ESA's Climate Change Initiative in order to create a long-term record of key geophysical parameters. All of these activities can only be carried out in international cooperation. Accordingly, ESA maintains long-standing partnerships with other space agencies and relevant institutions worldwide. In running its Earth observation programmes, ESA responds to societal needs and challenges as well as to requirements resulting from political priorities, such as the United Nations' Sustainable Development Goals.

ESA on RAINEWS24: A Case Study of Television Communication

NASA Astrophysics Data System (ADS)

Sandrelli, S.

2005-12-01

In May 2000, ESRIN, the Italian establishment of the European Space Agency (ESA), started a collaboration with the television channel Rainews24. Rainews24 is the "allnews" channel of Italian public television (RAI) and is now about 10 years old. It transmits 24 hours a day and is the most watched all-news satellite channel in Italy. Each Thursday an ESA representative (Stefano Sandrelli) is interviewed by a professional RAI journalist in a 5-6 minute long slot that follows the 5 pm news bulletin. The broadcast is repeated late at night or in the early hours of Thursday and Friday. Interviews are strictly linked to the weekly news and are prepared on the morning of the same day by the ESA representative in collaboration with a RAI journalist. The subject is chosen from the most topical news items of the week: video, images and animations are provided by the ESA television service and by press agencies (Reuters etc.). The interviews are largely informal and resemble a dialogue rather than an academic discussion "from space". Even though they focus on ESA activities, they are not advertisements: space science and research is dealt with as a human activity, so both the positive and negative aspects of space exploration and exploitation may emerge. Although this outreach activity began as an experiment, the ESA interviews have become a fixed feature. As a result of five years of uninterrupted collaboration, over 200 interviews have been recorded, with about 30% of the interviews dedicated to pure astronomy. A welcome positive feature is that the interviews are seen by Rainews24 as an open source of daily news.

Epoxy Stearic Acid, an Oxidative Product Derived from Oleic Acid, Induces Cytotoxicity, Oxidative Stress, and Apoptosis in HepG2 Cells.

PubMed

Liu, Ying; Cheng, Yajun; Li, Jinwei; Wang, Yuanpeng; Liu, Yuanfa

2018-05-23

In the present study, effects of cis-9,10-epoxy stearic acid (ESA) generated by the thermal oxidation of oleic acid on HepG2 cells, including cytotoxicity, apoptosis, and oxidative stress, were investigated. Our results revealed that ESA decreased the cell viability and induced cell death. Cell cycle analysis with propidium iodide staining showed that ESA induced cell cycle arrest at the G0/G1 phase in HepG2 cells. Cell apoptosis analysis with annexin V and propidium iodide staining demonstrated that ESA induced HepG2 cell apoptotic events in a dose- and time-dependent manner; the apoptosis of cells after treated with 500 μM ESA for 12, 24, and 48 h was 32.16, 38.70, and 65.80%, respectively. Furthermore, ESA treatment to HepG2 cells resulted in an increase in reactive oxygen species and malondialdehyde (from 0.84 ± 0.02 to 8.90 ± 0.50 nmol/mg of protein) levels and a reduction in antioxidant enzyme activity, including superoxide dismutase (from 1.34 ± 0.27 to 0.10 ± 0.007 units/mg of protein), catalase (from 100.04 ± 5.05 to 20.09 ± 3.00 units/mg of protein), and glutathione peroxidase (from 120.44 ± 7.62 to 35.84 ± 5.99 milliunits/mg of protein). These findings provide critical information on the effects of ESA on HepG2 cells, particularly cytotoxicity and oxidative stress, which is important for the evaluation of the biosafety of the oxidative product of oleic acid.

Oncology Nurses' Attitudes Toward the Edmonton Symptom Assessment System: Results From a Large Cancer Care Ontario Study.

PubMed

Green, Esther; Yuen, Dora; Chasen, Martin; Amernic, Heidi; Shabestari, Omid; Brundage, Michael; Krzyzanowska, Monika K; Klinger, Christopher; Ismail, Zahra; Pereira, José

2017-01-01

To examine oncology nurses' attitudes toward and reported use of the Edmonton Symptom Assessment System (ESAS) and to determine whether the length of work experience and presence of oncology certification are associated with their attitudes and reported usage.
. Exploratory, mixed-methods study employing a questionnaire approach.
. 14 regional cancer centers (RCCs) in Ontario, Canada.
. Oncology nurses who took part in a larger province-wide study that surveyed 960 interdisciplinary providers in oncology care settings at all of Ontario's 14 RCCs.
. Oncology nurses' attitudes and use of ESAS were measured using a 21-item investigator-developed questionnaire. Descriptive statistics and Kendall's tau-b or tau-c test were used for data analyses. Qualitative responses were analyzed using content analysis.
. Attitudes toward and self-reported use of standardized symptom screening and ESAS.
. More than half of the participants agreed that ESAS improves symptom screening, most said they would encourage their patients to complete ESAS, and most felt that managing symptoms is within their scope of practice and clinical responsibilities. Qualitative comments provided additional information elucidating the quantitative responses. Statistical analyses revealed that oncology nurses who have 10 years or less of work experience were more likely to agree that the use of standardized, valid instruments to screen for and assess symptoms should be considered best practice, ESAS improves symptom screening, and ESAS enables them to better manage patients' symptoms. No statistically significant difference was found between oncology-certified RNs and noncertified RNs on attitudes or reported use of ESAS.
. Implementing a population-based symptom screening approach is a major undertaking. The current study found that oncology nurses recognize the value of standardized screening, as demonstrated by their attitudes toward ESAS.
. Oncology nurses are integral to providing high-quality person-centered care. Using standardized approaches that enable patients to self-report symptoms and understanding barriers and enablers to optimal use of patient-reported outcome tools can improve the quality of patient care.

Latest processing status and quality assessment of the GOMOS, MIPAS and SCIAMACHY ESA dataset

NASA Astrophysics Data System (ADS)

Niro, F.; Brizzi, G.; Saavedra de Miguel, L.; Scarpino, G.; Dehn, A.; Fehr, T.; von Kuhlmann, R.

2011-12-01

GOMOS, MIPAS and SCIAMACHY instruments are successfully observing the changing Earth's atmosphere since the launch of the ENVISAT-ESA platform on March 2002. The measurements recorded by these instruments are relevant for the Atmospheric-Chemistry community both in terms of time extent and variety of observing geometry and techniques. In order to fully exploit these measurements, it is crucial to maintain a good reliability in the data processing and distribution and to continuously improving the scientific output. The goal is to meet the evolving needs of both the near-real-time and research applications. Within this frame, the ESA operational processor remains the reference code, although many scientific algorithms are nowadays available to the users. In fact, the ESA algorithm has a well-established calibration and validation scheme, a certified quality assessment process and the possibility to reach a wide users' community. Moreover, the ESA algorithm upgrade procedures and the re-processing performances have much improved during last two years, thanks to the recent updates of the Ground Segment infrastructure and overall organization. The aim of this paper is to promote the usage and stress the quality of the ESA operational dataset for the GOMOS, MIPAS and SCIAMACHY missions. The recent upgrades in the ESA processor (GOMOS V6, MIPAS V5 and SCIAMACHY V5) will be presented, with detailed information on improvements in the scientific output and preliminary validation results. The planned algorithm evolution and on-going re-processing campaigns will be mentioned that involves the adoption of advanced set-up, such as the MIPAS V6 re-processing on a clouds-computing system. Finally, the quality control process will be illustrated that allows to guarantee a standard of quality to the users. In fact, the operational ESA algorithm is carefully tested before switching into operations and the near-real time and off-line production is thoughtfully verified via the implementation of automatic quality control procedures. The scientific validity of the ESA dataset will be additionally illustrated with examples of applications that can be supported, such as ozone-hole monitoring, volcanic ash detection and analysis of atmospheric composition changes during the past years.

Are you ready for Mars? - Main media events surrounding the arrival of ESA's Mars Express at Mars

NASA Astrophysics Data System (ADS)

2003-11-01

Launched on 2 June 2003 from Baikonur (Kazakhstan) on board a Russian Soyuz launcher operated by Starsem, the European probe -built for ESA by a European team of industrial companies led by Astrium - carries seven scientific instruments that will perform a series of remote-sensing experiments designed to shed new light on the Martian atmosphere, the planet’s structure and its geology. In particular, the British-made Beagle 2 lander, named after the ship on which Charles Darwin explored uncharted areas of the Earth in 1830, will contribute to the search for traces of life on Mars through exobiology experiments and geochemistry research. On Christmas Eve the Mars Express orbiter will be steered on a course taking it into an elliptical orbit, where it will safely circle the planet for a minimum of almost 2 Earth years. The Beagle 2 lander - which will have been released from the mother craft a few days earlier (on 19 December) - instead will stay on a collision course with the planet. It too should also be safe, being designed for atmospheric entry and geared for a final soft landing due to a sophisticated system of parachutes and airbags. On arrival, the Mars Express mission control team will report on the outcome of the spacecraft's delicate orbital insertion manoeuvre. It will take some time for Mars Express to manouvre into position to pick communications from Beagle 2. Hence, initially, other means will be used to check that Beagle 2 has landed: first signals from the Beagle 2 landing are expected to be available throughout Christmas Day, either through pick-up and relay of Beagle 2 radio signals by NASA’s Mars Odyssey, or by direct pick-up by the Jodrell Bank radio telescope in the UK. Mars Express will then pass over Beagle 2 in early January 2004, relaying data and images back to Earth. The first images from the cameras of Beagle 2 and Mars Express are expected to be available between the end of the year and the beginning of January 2004. The key dates relating to the arrival of Mars Express at its destination will be marked by several media events not to be missed. Pencil them into your diaries so as not to miss one of the most exciting events of the year. Tuesday 11 November Mars Express/Beagle 2 Media briefing Royal Society- 6-9 Carlton House Terrace, London 10:00 - 13:00 -Status report on the mission -Technical details on forthcoming Mars Express/Beagle 2 operations -News handling arrangements around Christmas Speakers: Prof. David Southwood, ESA Director of Science; Prof. Colin Pillinger, Beagle 2 Lander Lead Scientist; John Reddy, ESA Mars Express Principal Electrical Systems Engineer. Contact: Peter Barratt, PPARC Tel. + 44 (0) 1793 44 20 25 e-mail: Beagle2@pparc.ac.uk Wednesday 3 December ESA Media briefing ESA/ ESOC, Darmstadt, Germany 10:30 - 12:30 -Scientific outlook and expected results -Status report on the mission -Presentation of upcoming events Speakers: Rudolf Schmidt, ESA Mars Express Project Manager; Augustin Chicarro, ESA Mars Express Project Scientist. In addition, Mars Express scientists and Mission Control Managers will highlight their contribution to the Mars Express mission. In videoconference with ESA/Headquarters, Paris (F); ESA/ESTEC, Noordwijk (NL), ESA/ESRIN, Frascati (I). Contact: Jocelyne Landeau Constantin, ESA/ESOC Tel. + 49 6151 90 26 96 e-mail: Jocelyne.Landeau-Constantin@esa.int Friday 19 December Mars Express Orbiter/ Beagle 2 separation Mission Control Managers announce results of Beagle 2 separation from the mother craft. a.Event at ESA/ESOC, Darmstadt , Germany 08:30 - 14:00 Speakers: Prof. David Southwood, ESA Director of Science; Rudolf Schmidt, ESA Mars Express Project Manager Contact: Jocelyne Landeau Constantin, ESA/ESOC Tel. + 49 6151 90 26 96 e-mail: Jocelyne.Landeau-Constantin@esa.int b.Event in London -location and time t.b.c. Speaker: Prof. Colin Pillinger, Beagle 2 Lander Lead Scientist. Contact: Peter Barratt, PPARC Tel. + 44 (0) 1793 44 20 25 e-mail: Beagle2@pparc.ac.uk Thursday 25 December Christmas on Mars a.Media event at ESA/ ESOC, Darmstadt, Germany 03:00 - 07:00 Mars Express orbit insertion follow-up and Beagle 2 landing- Experience the accomplishment of one of the most exciting phases of the Mars Express mission in real time in the presence of Mission Control Managers and Scientists. 08:30 - 10:00 Christmas media brunch- Announcement of Mars orbit insertion results and Beagle 2 landing, with the participation of Prof. David Sourthwood, ESA Director of Science. Contact: Jocelyne Landeau Constantin, ESA/ESOC Tel. + 49 6151 90 26 96 e-mail: Jocelyne.Landeau-Constantin@esa.int b.Event in central London - location and time t.b.c. Contact: Peter Barratt, PPARC Tel. + 44 (0) 1793 44 20 25 e-mail: Beagle2@pparc.ac.uk Note to Editors: Timeline of expected main mission events 16 December All day Fine targeting of Mars Express to point at landing site - ranging 19 December 06:51 GMT/07:51 CET Decision to release Beagle 2 08:41 GMT/09:41 CET Eject command sent to Mars Express 10:15 GMT/11:15 CET First results of release available 20 December Re-targeting of Mars Express on an orbital insertion course 23 December Update on Mars Express Orbital Insertion Sequence 24 December Night Final decision to steer Mars Express into a Martian orbit 25 December 02:45 GMT/03:45 CET Beagle 2 landing on Mars 03:00 GMT/04:00 CET Mars Express Orbital Insertion 05:15 GMT/06:15 CET Mars Odyssey orbiter flight over Beagle 2 07:00 GMT/08:00 CET First evaluation of Mars Express orbital insertion 22:45 GMT/23:45 CET Possible direct capture of Beagle 2 signals at Jodrell Bank (UK)

Transitions Towards Operational Space-Based Ocean Observations: From Single Research Missions into Series and Constellations

DTIC Science & Technology

2011-02-16

Meleorol. Soc... 88 (8). 1197-121.1. 2007 . (DOI: 10.1175/ BAMS-88-8-1197) 4. GCOS Implementation Plan for the Global Observing System for Climate...21-25 September 2009, Hall, J.. Harrison 1) 1 and Stammer . D., Eds., ESA Publication WPP-306, 2010. 6. Le Traon, P.-Y.. and Co-Authors (2010...Information for Society" Conference (Vol. 2), Venice, Italy, 21-25 September 2009, Hall, J., Harrison D.E. and Stammer , D., Eds., ESA Publication WPP

A Unique test for Hubble's new Solar Arrays

NASA Astrophysics Data System (ADS)

2000-10-01

In mid-October, a team from the European Space Agency (ESA) and NASA will perform a difficult, never-before-done test on one of the Hubble Space Telescope's new solar array panels. Two of these panels, or arrays, will be installed by astronauts in November 2001, when the Space Shuttle Columbia visits Hubble on a routine service mission. The test will ensure that the new arrays are solid and vibration free before they are installed on orbit. The test will be conducted at ESA's European Space Research and Technology Center (ESTEC) in Noordwijk, The Netherlands. Because of the array's size, the facility's special features, and ESA's longstanding experience with Hubble's solar arrays, ESTEC is the only place in the world the test can be performed. This test is the latest chapter in a longstanding partnership between ESA and NASA on the Hubble Space Telescope. The Large Space Simulator at ESTEC, ESA's world-class test facility, features a huge vacuum chamber containing a bank of extremely bright lights that simulate the Sun's intensity - including sunrise and sunset. By exposing the solar wing to the light and temperature extremes of Hubble's orbit, engineers can verify how the new set of arrays will act in space. Hubble orbits the Earth once every 90 minutes. During each orbit, the telescope experiences 45 minutes of searing sunlight and 45 minutes of frigid darkness. This test will detect any tiny vibrations, or jitters, caused by these dramatic, repeated changes. Even a small amount of jitter can affect Hubble's sensitive instruments and interfere with observations. Hubble's first set of solar arrays experienced mild jitter and was replaced in 1993 with a much more stable pair. Since that time, advances in solar cell technology have led to the development of even more efficient arrays. In 2001, NASA will take advantage of these improvements, by fitting Hubble with a third-generation set of arrays. Though smaller, this new set generates more power than the previous pairs. The arrays use high efficiency solar cells and an advanced structural system to support the solar panels. Unlike the earlier sets, which roll up like window shades, the new arrays are rigid. ESA provided Hubble's first two sets of solar arrays, and built and tested the motors and electronics of the new set provided by NASA Goddard Space Flight Center. Now, this NASA/ESA test has benefits that extend beyond Hubble to the world-wide aerospace community. It will greatly expand basic knowledge of the jitter phenomenon. Engineers across the globe can apply these findings to other spacecraft that are subjected to regular, dramatic changes in sunlight and temperature. Note to editors The Hubble Project The Hubble Space Telescope is a project of international co-operation between the National Aeronautics and Space Administration (NASA) and the European Space Agency (ESA). The partnership agreement between ESA and NASA was signed on 7 October 1977. ESA has provided two pairs of solar panels and one of Hubble's scientific instruments (the Faint Object Camera), as well as a number of other components and supports NASA during routine Servicing Missions to the telescope. In addition, 15 European scientists are working at the Space Telescope Science Institute in Baltimore (STScI), which is responsible for the scientific operation of the Hubble Observatory and is managed by the Association of Universities for Research in Astronomy (AURA) for NASA. In return, European astronomers have guaranteed access to 15% of Hubble's observing time. The Space Telescope European Coordinating Facility (ST-ECF) hosted at the European Southern Observatory (ESO) in Garching bei München, Germany, supports European Hubble users. ESA and ESO jointly operate the ST-ECF.

Solar mystery nears solution with data from SOHO spacecraft

NASA Astrophysics Data System (ADS)

1997-11-01

Since the corona's temperature was first measured 55 years ago, scientists have lacked a satisfactory explanation for why that temperature is over one million degrees while the visible surface of the Sun is only about 6,000 degrees Celsius. According to the laws of physics, thermal energy cannot flow from the cooler surface to the much hotter corona, so the energy transfer has to be in the form of waves or magnetic energy, but no measurement to date had found adequate energy to account for the corona's high temperature. "We now have direct evidence for the upward transfer of magnetic energy from the Sun's surface toward the corona above. There is more than enough energy coming up from the loops of the "magnetic carpet" to heat the corona to its known temperature", said Dr. Alan Title of the Stanford-Lockheed Institute for Space Research, Lockheed Martin Advanced Technology Center, Palo Alto, CA, who led the research. "Each one of these loops carries as much energy as a large hydroelectric plant, such as the Hoover dam, generates in about a million years !". "We now appear to be closing in on an explanation as to why the solar corona is over 100 times hotter than the solar surface - the solution to a 55-year old puzzle", said Dr. George Withbroe, Director of the Sun-Earth Connection Programme at NASA Headquarters, Washington DC. "These results underline the importance of long-term study of the changing conditions on the Sun from the superior vantage point of space". Energy flows from the loops when they interact, producing electric and magnetic "short circuits". The very strong electric currents in these short circuits are what heats the corona to a temperature of several million degrees. Images from the Extreme ultraviolet Imaging Telescope (EIT) and the Coronal Diagnostics Spectrometer (CDS) on SOHO show ever-changing brightenings of the hot gases in the corona in response - it is assumed -to the evolving magnetic fields rooted in the solar surface. The observations with SOHO's Michelson Doppler Imager (MDI) provided long-duration, highly detailed, and well calibrated time-lapse movies of the magnetic fields on the visible surface or "photosphere" of the Sun. These revealed the rapidly changing properties of what Title calls "the Sun's Magnetic Carpet" a sprinkling of tens-of-thousands of magnetic concentrations; These concentrations have both north and south magnetic poles, which are the "foot points" of magnetic loops extending into the solar corona. Like field biologists who study the populations and life cycles of animal herds, the SOHO researchers analysed the appearances and disappearances of large numbers of the small magnetic concentrations on the solar surface. "We find that after a typical small magnetic loop emerges, it fragments and drifts around and then disappears in only 40 hours" Title said. "It's very hard to understand how such a short-lived effect could be driven by the magnetic dynamo layer that is over 150,000 km beneath the surface of the Sun. This may be evidence that unknown processes are at work in or near the solar surface that continuously form these loops all over the Sun". Professor Phillip Scherrer of Stanford University is the MDI Principal Investigator. MDI was built at the LM Technology Center and is a project of the Stanford-Lockheed Institute for Space Research. The EIT and CDS instruments were built by international consortia under the leadership of, respectively, Dr. Richard A. Harrison of Rutherford-Appleton Laboratory near Oxford (UK) and Dr. Jean-Pierre Delaboudini[re of the Institut d'Astrophysique spatiale in Orsay (F). The new observations were made with these three instruments on SOHO, a spacecraft stationed 1,5 million Kilometres sunward of the Earth in interplanetary space, where it has an uninterrupted view of the Sun and of the solar wind particles blown from the Sun. The SOHO satellite developed by ESA and built by European industry is operated from a control center at NASA's Goddard Space Flight Center, Greenbelt, MD. SOHO was launched on 2 December 1995 aboard an Atlas-IIAS expendable launch vehicle from Kennedy Space Center, FL. Note to Editors : Images to support this story can be found at the following internet locations : ftp://pao.gsfc.nasa.gov/newsmedia/SSU For more information, please contact : ESA Public Relations Division Tel: +33.1(0)53.69.7155 Fax: +33.1(0)53.69.7690 P.S.Concerning the ESA's Information Note N 37-97 dated 06.11.97 "ISO proves that intergalactic space is dusty", please note that photos are available on Internet at : http://www.estec.esa.nl/spdwww/iso1211.htm

Lunar Exploration and Science in ESA

NASA Astrophysics Data System (ADS)

Carpenter, J.; Houdou, B.; Fisackerly, R.; De Rosa, D.; Espinasse, S.; Hufenbach, B.

2013-09-01

Lunar exploration continues to be a priority for the European Space Agency (ESA) and is recognized as the next step for human exploration beyond low Earth orbit. The Moon is also recognized as an important scientific target providing vital information on the history of the inner solar system; Earth and the emergence of life, and fundamental information on the formation and evolution of terrestrial planets. The Moon also provides a platform that can be utilized for fundamental science and to prepare the way for exploration deeper into space and towards a human Mars mission, the ultimate exploration goal. Lunar missions can also provide a means of preparing for a Mars sample return mission, which is an important long term robotic milestone. ESA is preparing for future participation in lunar exploration through a combination of human and robotic activities, in cooperation with international partners. These include activities on the ISS and participation with US led Multi-Purpose Crew Vehicle, which is planned for a first unmanned lunar flight in 2017. Future activities planned activities also include participation in international robotic missions. These activities are performed with a view to generating the technologies, capabilities, knowledge and heritage that will make Europe an indispensible partner in the exploration missions of the future. We present ESA's plans for Lunar exploration and the current status of activities. In particular we will show that this programme gives rise to unique scientific opportunities and prepares scientifically and technologically for future exploratory steps.

Validation of the Daily Passive Microwave Snow Depth Products Over Northern China

NASA Astrophysics Data System (ADS)

Qiao, D.; Li, Z.; Wang, N.; Zhou, J.; Zhang, P.; Gao, S.

2018-04-01

Passive microwave sensors have the capability to provide information on snow depth (SD), which is critically important for hydrological modeling and water resource management. However, the different algorithms used to produce SD products lead to discrepancies in the data. To determine which products might be most suitable for Northern China, this paper assesses the accuracy of the existing snow depth products in the period of 2002-2011. By comparing three daily snow depth products, including NSIDC, WESTDC and ESA Globsnow, with snow cover product and meteorological stations data, the accuracies of the different SD products are analyzed for different snow class and forest cover fraction. The results show that comparison between snow cover derived from snow depth of NSIDC, ESA GlobSnow and WESTDC with snow cover product shows that accuracy of WESTDC and ESA GlobSnow in snow cover detecting can reach 0.70. Compared to meteorological stations data below 20 cm, NSIDC consistently overestimate, WESTDC and ESA Globsnow underestimate, furthermore the product from WESTDC is superior to the others. The three products have the same tendency of significant undervaluation over 20 cm. The WESTDC is superior to the ESA Globsnow and NSIDC in non-forest regions, whereas the ESA GlobSnow estimate is superior to the WESTDC and NSIDC in forest regions. As for the prairie and alpine snow, WESTDC has smaller bias and RMSE, meanwhile Globsnow has advantages in the snow depth retrieval in tundra and taiga snow. Therefore, we should choose the more suitable snow depth products according to different needs.

Crew of Hubble Space Telescope servicing mission visits Europe

NASA Astrophysics Data System (ADS)

1994-01-01

The Hubble Space telescope servicing mission in December (STS-61) was a great success and the fully refurbished orbiting telescope produced absolutely remarkable first results just two weeks ago. The 7-member crew who carried out the mission will soon be in Europe to share their experience with the Press, ESA space specialists and the European space community. Public conferences will also be held in Switzerland, the home country of ESA astronaut Claude Nicollier. The visit of the STS-61 crew is scheduled as follows: Friday 11 February, 1994 - ESA Paris, France Presentation and Press Conference Location: ESA, 8/10 Rue Mario Nikis, 75015 Paris time: 16:00 hrs - 17:30 hrs contact: ESA, Public Relations Office Tel. (+33) 1 42 73 71 55 Fax. (+33) 1 42 73 76 90 Monday 14 February, 1994 - British Aerospace, Bristol, United Kingdom Presentation and Press Conference Location: British Aerospace, FPC 333, Filton, Bristol BS12 7QW time: 10:00 hrs - 12:00 hrs contact: BAe, Public Relations Tel. (+44) 272 36 33 69 Tel. (+44) 272 36 33 68 Tuesday 15 February, 1994 - ESA/ESTEC, Noordwijk, the Netherlands Presentation and Press Conference Location: Noordwijk Space Expo, Keplerlaan 3, 2201 AZ Noordwijk, the Netherlands time: 09:30 hrs - 12:00 hrs contact: ESTEC Public Relations Office Tel. (+31) 1719 8 3006 Fax. (+31) 1719 17 400 Wednesday 16 February, 1944 - ESO, Garching - Munich, Germany Presentation and Press Conference Location: European Southern Observatory, Karl- Schwarzschild-Str. 2, 85748 Garching -Munich, Germany time: to be decided contact: ESO Information Service Tel. (+49) 89 32 006 276 Fax. (+49) 89 320 23 62 Thursday 17 February, 1994 - Bern, Switzerland a. Presentation and Press Conference Location: Hotel Bern, Zeughausgasse 9, 3001 Bern, Switzerland time: 09:30 hrs contact: Press & Information Service of the Federal Dept. for Education & Sciences Tel. (+41) 31 322 80 34 Fax. (+41) 31 312 30 15 b. Public conference Location: University of Bern, Institute of Physics time: 18:00 hrs - 20:00 hrs Friday 18 February, 1994 - Geneva, Switzerland a. Presentation and Press Conference Location: Geneva Observatory, Chemin des Maillettes 51, 1290 Sauverny, Switzerland time: 10:00 hrs - 11:30 hrs contact: Press Service University of Geneva Tel. (+41) 22 705 77 17 Tel. (+41) 22 328 25 66 b. Public Conference Location: University of Geneva, Auditorium Piaget, Uni Dufour time: 18:00 hrs - 20:30 hrs For accreditation and further information on these events, please get in touch directly with the contact listed for each location.

Predictive factors for anemia response to erythropoiesis-stimulating agents in myelofibrosis.

PubMed

Hernández-Boluda, Juan-Carlos; Correa, Juan-Gonzalo; García-Delgado, Regina; Martínez-López, Joaquín; Alvarez-Larrán, Alberto; Fox, María-Laura; García-Gutiérrez, Valentín; Pérez-Encinas, Manuel; Ferrer-Marín, Francisca; Mata-Vázquez, María-Isabel; Raya, José-María; Estrada, Natalia; García, Silvia; Kerguelen, Ana; Durán, María-Antonia; Albors, Manuel; Cervantes, Francisco

2017-04-01

Erythropoiesis-stimulating agents (ESAs) are commonly used to treat the anemia of myelofibrosis (MF), but information on the predictors of response is limited. Results of ESA therapy were analyzed in 163 MF patients with severe anemia, most of whom had inadequate erythropoietin (EPO) levels (<125 U/L) at treatment start. According to the revised criteria of the International Working Group for Myelofibrosis Treatment and Research, anemia response was achieved in 86 patients (53%). Median response duration was 19.3 months. In multivariate analysis, baseline factors associated with a higher response rate were female sex (P=.007), leukocyte count ≥10×10 9 /L (P=.033), and serum ferritin <200 ng/mL (P=.002). Patients with 2 or 3 of the above features had a significantly higher response rate than the remainder (73% vs 28%, respectively; P<.001). Over the 373 patient-years of follow-up on ESA treatment, nine patients developed thrombotic complications (six arterial, three venous), accounting for 2.41 events per 100 patient-years. Survival time from ESA start was longer in anemia responders than in non-responders (P=.011). Besides the already established predictive value of EPO levels, these data can help to identify which MF patients are more likely to benefit from ESA treatment. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Spectroscopic and Photometric Survey of Northern Sky for the ESA PLATO space mission

NASA Astrophysics Data System (ADS)

Ženovienė, Renata; Bagdonas, Vilius; Drazdauskas, Arnas; Janulis, Rimvydas; Klebonas, Lukas; Mikolaitis, Šarūnas; Pakštienė, Erika; Tautvaišienė, Gražina

2018-04-01

The ESA-PLATO 2.0 mission will perform an in-depth analysis of the large part of the sky-sphere searching for extraterrestrial telluric-like planets. At the Molėtai Astronomical Observatory of Vilnius University, we started a spectroscopic and photometric survey of the northern sky fields that potentially will be targeted by the PLATO mission. We aim to contribute in developing the PLATO input catalogue by delivering a long-duration stellar variability information and a full spectroscopic characterization of brightest targets. First results of this survey are overviewed.

Use of Electronic Tag Data and Associated Analytical Tools to Identify and Predict Habitat Utilization of Marine Mammals

DTIC Science & Technology

2010-09-30

the fractal landscape method to determine regions of area restricted search (ARS) (Jonsen et al. 2003; Jonsen et al. 2006; Tremblay et al. 2007 ). Next...Information for Society (Vol. 2), Venice, Italy, 21-25 September 2009, Hall, J., Harrison, D.E. & Stammer , D., Eds., ESA Publication WPP-306. O’Dor...D.E. & Stammer , D., Eds., ESA Publication WPP-306. Žydelis, R., Lewison, R.L., Shaffer, S. A., Moore, J.E., Boustany, A.M., Roberts, J.J., Sims

76 FR 55363 - Proposed Information Collection; Comment Request; Seafood Inspection and Certification Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-07

... Act of 1973 (ESA; 16 U.S.C. 1531 et seq.) imposed prohibitions against the taking of endangered... approvals, 15 minutes; and inspection requests, 30 minutes. Estimated Total Annual Burden Hours: 7,698... collection of information; (c) ways to enhance the quality, utility, and clarity of the information to be...

Early development of Science Opportunity Analysis tools for the Jupiter Icy Moons Explorer (JUICE) mission

NASA Astrophysics Data System (ADS)

Cardesin Moinelo, Alejandro; Vallat, Claire; Altobelli, Nicolas; Frew, David; Llorente, Rosario; Costa, Marc; Almeida, Miguel; Witasse, Olivier

2016-10-01

JUICE is the first large mission in the framework of ESA's Cosmic Vision 2015-2025 program. JUICE will survey the Jovian system with a special focus on three of the Galilean Moons: Europa, Ganymede and Callisto.The mission has recently been adopted and big efforts are being made by the Science Operations Center (SOC) at the European Space and Astronomy Centre (ESAC) in Madrid for the development of tools to provide the necessary support to the Science Working Team (SWT) for science opportunity analysis and early assessment of science operation scenarios. This contribution will outline some of the tools being developed within ESA and in collaboration with the Navigation and Ancillary Information Facility (NAIF) at JPL.The Mission Analysis and Payload Planning Support (MAPPS) is developed by ESA and has been used by most of ESA's planetary missions to generate and validate science observation timelines for the simulation of payload and spacecraft operations. MAPPS has the capability to compute and display all the necessary geometrical information such as the distances, illumination angles and projected field-of-view of an imaging instrument on the surface of the given body and a preliminary setup is already in place for the early assessment of JUICE science operations.NAIF provides valuable SPICE support to the JUICE mission and several tools are being developed to compute and visualize science opportunities. In particular the WebGeoCalc and Cosmographia systems are provided by NAIF to compute time windows and create animations of the observation geometry available via traditional SPICE data files, such as planet orbits, spacecraft trajectory, spacecraft orientation, instrument field-of-view "cones" and instrument footprints. Other software tools are being developed by ESA and other collaborating partners to support the science opportunity analysis for all missions, like the SOLab (Science Operations Laboratory) or new interfaces for observation definitions and opportunity window databases.

Hubble confirms cosmic acceleration with weak lensing

NASA Image and Video Library

2017-12-08

NASA/ESA Hubble Release Date: March 25, 2010 This image shows a smoothed reconstruction of the total (mostly dark) matter distribution in the COSMOS field, created from data taken by the NASA/ESA Hubble Space Telescope and ground-based telescopes. It was inferred from the weak gravitational lensing distortions that are imprinted onto the shapes of background galaxies. The colour coding indicates the distance of the foreground mass concentrations as gathered from the weak lensing effect. Structures shown in white, cyan, and green are typically closer to us than those indicated in orange and red. To improve the resolution of the map, data from galaxies both with and without redshift information were used. The new study presents the most comprehensive analysis of data from the COSMOS survey. The researchers have, for the first time ever, used Hubble and the natural "weak lenses" in space to characterise the accelerated expansion of the Universe. Credit: NASA, ESA, P. Simon (University of Bonn) and T. Schrabback (Leiden Observatory) To learn more abou this image go to: www.spacetelescope.org/news/html/heic1005.html For more information about Goddard Space Flight Center go here: www.nasa.gov/centers/goddard/home/index.html

The effectiveness and cost-effectiveness of erythropoiesis-stimulating agents (epoetin and darbepoetin) for treating cancer treatment-induced anaemia (including review of technology appraisal no. 142): a systematic review and economic model.

PubMed

Crathorne, Louise; Huxley, Nicola; Haasova, Marcela; Snowsill, Tristan; Jones-Hughes, Tracey; Hoyle, Martin; Briscoe, Simon; Coelho, Helen; Long, Linda; Medina-Lara, Antonieta; Mujica-Mota, Ruben; Napier, Mark; Hyde, Chris

2016-02-01

Anaemia is a common side effect of cancer treatments and can lead to a reduction in quality of life. Erythropoiesis-stimulating agents (ESAs) are licensed for use in conjunction with red blood cell transfusions to improve cancer treatment-induced anaemia (CIA). To investigate the effectiveness and cost-effectiveness of ESAs in anaemia associated with cancer treatment (specifically chemotherapy). The following databases were searched from 2004 to 2013: The Cochrane Library, MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, EMBASE, Web of Science, Cumulative Index to Nursing and Allied Health Literature, British Nursing Index, Health Management Information Consortium, Current Controlled Trials and ClinicalTrials.gov. The US Food and Drug Administration and European Medicines Agency websites were also searched. Bibliographies of included papers were scrutinised for further potentially includable studies. The clinical effectiveness review followed principles published by the NHS Centre for Reviews and Dissemination. Randomised controlled trials (RCTs), or systematic reviews of RCTs, of ESAs (epoetin or darbepoetin) for treating people with CIA were eligible for inclusion in the review. Comparators were best supportive care, placebo or other ESAs. Anaemia- and malignancy-related outcomes, health-related quality of life (HRQoL) and adverse events (AEs) were evaluated. When appropriate, data were pooled using meta-analysis. An empirical health economic model was developed comparing ESA treatment with no ESA treatment. The model comprised two components: one evaluating short-term costs and quality-adjusted life-years (QALYs) (while patients are anaemic) and one evaluating long-term QALYs. Costs and benefits were discounted at 3.5% per annum. Probabilistic and univariate deterministic sensitivity analyses were performed. Of 1457 titles and abstracts screened, 23 studies assessing ESAs within their licensed indication (based on start dose administered) were included in the review. None of the RCTs were completely aligned with current European Union licenses. The results suggest a clinical benefit from ESAs for anaemia-related outcomes and an improvement in HRQoL scores. The impact of ESAs on AEs and survival remains highly uncertain, although point estimates are lower, confidence intervals are wide and not statistically significant. Base-case incremental cost-effectiveness ratios (ICERs) for ESA treatment compared with no ESA treatment ranged from £ 19,429 to £ 35,018 per QALY gained, but sensitivity and scenario analyses demonstrate considerable uncertainty in these ICERs, including the possibility of overall health disbenefit. All ICERs were sensitive to survival and cost. The relative effectiveness of ESAs was not addressed; all ESAs were assumed to have equivalent efficacy. No studies were completely aligned with their European labelling beyond the starting dose evaluated. There is questionable generalisability given that the included trials were published >20 years ago and there have been many changes to chemotherapy as well as to the quality of supportive treatment. Trial quality was moderate or poor and there was considerable unexplained heterogeneity for a number of outcomes, particularly survival, and evidence of publication bias. Adjustments were not made to account for multiple testing. ESAs could be cost-effective when used closer to licence, but there is considerable uncertainty, mainly because of unknown impacts on overall survival. This study is registered as PROSPERO CRD42013005812. The National Institute for Health Research Health Technology Assessment programme.

30 CFR 250.216 - What biological, physical, and socioeconomic information must accompany the EP?

Code of Federal Regulations, 2011 CFR

2011-07-01

.... Site-specific information on chemosynthetic communities, federally listed threatened or endangered species, marine mammals protected under the Marine Mammal Protection Act (MMPA), sensitive underwater features, marine sanctuaries, critical habitat designated under the Endangered Species Act (ESA), or other...

Validation of the French Version of the Edmonton Symptom Assessment System.

PubMed

Pautex, Sophie; Vayne-Bossert, Petra; Bernard, Mathieu; Beauverd, Michel; Cantin, Boris; Mazzocato, Claudia; Thollet, Catherine; Bollondi-Pauly, Catherine; Ducloux, Dominique; Herrmann, François; Escher, Monica

2017-11-01

The Edmonton Symptom Assessment System (ESAS) is a brief, widely adopted, multidimensional questionnaire to evaluate patient-reported symptoms. The objective of this study was to define a standard French version of the ESAS (F-ESAS) to determine the psychometric properties in French-speaking patients. In a first pilot study, health professionals (n = 20) and patients (n = 33) defined the most adapted terms in French (F-ESAS). In a prospective multicentric study, palliative care patients completed the three forms of F-ESAS (F-ESAS-VI, F-ESAS-VE, and F-ESAS-NU, where VI is visual, VE, verbal, and NU, numerical), the Hospital Anxiety and Depression Scale. All patients had a test-retest evaluation during the same half-day. Standardized distraction material was used between each scale. One hundred twenty-four patients were included (mean age [±SD]: 68.3 ± 12; 70 women; 54 men). Test-retest reliability was high for all three F-ESAS, and the correlation between these scales was nearly perfect (Spearman rs = 0.66-0.91; P < 0.05). F-ESAS-VI, F-ESAS-VE, and F-ESAS-NU performed similarly and were equally reliable, although there was a trend toward lower reliability for F-ESAS-VI. Correlation between F-ESAS depression and anxiety and HADS depression and anxiety, respectively, were positive (Spearman rs = 0.38-0.41 for depression; Spearman rs = 0.48-0.57 for anxiety, P < 0.05). Among patients, 59 (48%), 45 (36%), and 20 (16%) preferred to assess their symptoms with F-ESAS-VE, F-ESAS-NU, and F-ESAS-VI, respectively. The F-ESAS is a valid and reliable tool for measuring multidimensional symptoms in French-speaking patients with an advanced cancer. All forms of F-ESAS performed well with a trend for better psychometric performance for F-ESAS-NU, but patients preferred the F-ESAS-VE. Copyright © 2017. Published by Elsevier Inc.

KSC-2013-2882

NASA Image and Video Library

2013-06-20

CAPE CANAVERAL, Fla. – Representatives from the European Space Agency, or ESA, toured the Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida. Pointing at thermal protection system tiles is Jules Schneider, Lockheed Martin senior manager. At right, in the blue suit, is Bernardo Patti, ESA manager of International Space Station Operations. Standing next to Patti is Nico Dettman, ESA Space Transportation Department director. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

Validating Cryosat-2 elevation estimates with airborne laser scanner data for the Greenland ice sheet, Austfonna and Devon ice caps

NASA Astrophysics Data System (ADS)

Simonsen, Sebastian B.; Sandberg Sørensen, Louise; Nilsson, Johan; Helm, Veit; Langley, Kirsty A.; Forsberg, Rene; Hvidegaard, Sine M.; Skourup, Henriette

2015-04-01

The ESA CryoSat-2 satellite, launched in late 2010, carries a new type of radar altimeter especially designed for monitoring changes of sea and land ice. The radar signal might penetrate into the snow pack and the depth of the radar reflecting surface depends on the ratio between the surface and the volume backscatter, which is a function of several different properties such as snow density, crystal structure and surface roughness. In case of large volume scatter, the radar waveforms become broad and the determination of the range (surface elevation) becomes more difficult. Different algorithms (retrackers) are used for the range determination, and estimated surface penetration is highly dependent on the applied retracker. As part of the ESA-CryoVEx/CryoVal-Land Ice projects, DTU Space has gathered accurate airborne laser scanner elevation measurements. Sites on the Greenland ice sheet, Austfonna and Devon ice caps, has been surveyed repeatedly, aligned with Cryosat-2 ground tracks and surface experiments. Here, we utilize elevation estimates from available Cryosat-2 retrackers (ESA level-2 retracker, DTU retracker, etc.) and validate the elevation measurements against ESA-CryoVEx campaigns. A difference between laser and radar elevations is expected due to radar penetration issues, however an inter-comparison between retrackers will shed light on individual performances and biases. Additionally, the geo-location of the radar return will also be a determining factor for the precision. Ultimately, the use of multiple retrackers can provide information about subsurface conditions and utilize more of the waveform information than presently used in radar altimetry.

A Study of TRMM Static Earth Sensor Performance Using On-Orbit Sensor Data

NASA Technical Reports Server (NTRS)

Natanson, Gregory; Glickman, Jonathan

2000-01-01

This paper presents the results of a study of the Barnes static Earth sensor assembly (ESA) using on-orbit data collected from the Tropical Rainfall Measuring Mission (TRMM) spacecraft. It is shown that there exist strong correlations between the large penetration angle residuals and the voltages produced by the Offset Radiation Source (ORS). It is conjectured that at certain times in the TRMM orbit the ORS is operating out of its calibrated range, and consequently corrupts the penetration angle information observed and processed by the ESA. The observed yaw drift between Digital Sun Sensor (DSS) observations is shown to be consistent with predictions by a simple roll-yaw coupling computation. This would explain the large drifts seen on TRMM, where the propagation of the yaw angle between DSS updates does not take into account the possibility of a non-zero roll angle error. Finally, the accuracy of the onboard algorithm used when only three of the four quadrants supply valid penetration angles is assessed. In terms of procedures used to perform this study, the analysis of ESA penetration angle residuals is discovered to be a very useful and insightful tool for assessing, the health and functionality of the ESA.

Electronic structure of atoms: atomic spectroscopy information system

NASA Astrophysics Data System (ADS)

Kazakov, V. V.; Kazakov, V. G.; Kovalev, V. S.; Meshkov, O. I.; Yatsenko, A. S.

2017-10-01

The article presents a Russian atomic spectroscopy, information system electronic structure of atoms (IS ESA) (http://grotrian.nsu.ru), and describes its main features and options to support research and training. The database contains over 234 000 records, great attention paid to experimental data and uniform filling of the database for all atomic numbers Z, including classified levels and transitions of rare earth and transuranic elements and their ions. Original means of visualization of scientific data in the form of spectrograms and Grotrian diagrams have been proposed. Presentation of spectral data in the form of interactive color charts facilitates understanding and analysis of properties of atomic systems. The use of the spectral data of the IS ESA together with its functionality is effective for solving various scientific problems and training of specialists.

30 CFR 250.216 - What biological, physical, and socioeconomic information must accompany the EP?

Code of Federal Regulations, 2010 CFR

2010-07-01

... information on chemosynthetic communities, federally listed threatened or endangered species, marine mammals protected under the Marine Mammal Protection Act (MMPA), sensitive underwater features, marine sanctuaries, critical habitat designated under the Endangered Species Act (ESA), or other areas of biological concern...

30 CFR 550.216 - What biological, physical, and socioeconomic information must accompany the EP?

Code of Federal Regulations, 2012 CFR

2012-07-01

... information on chemosynthetic communities, federally listed threatened or endangered species, marine mammals protected under the Marine Mammal Protection Act (MMPA), sensitive underwater features, marine sanctuaries, critical habitat designated under the Endangered Species Act (ESA), or other areas of biological concern...

30 CFR 550.216 - What biological, physical, and socioeconomic information must accompany the EP?

Code of Federal Regulations, 2014 CFR

2014-07-01

... information on chemosynthetic communities, federally listed threatened or endangered species, marine mammals protected under the Marine Mammal Protection Act (MMPA), sensitive underwater features, marine sanctuaries, critical habitat designated under the Endangered Species Act (ESA), or other areas of biological concern...

30 CFR 550.216 - What biological, physical, and socioeconomic information must accompany the EP?

Code of Federal Regulations, 2013 CFR

2013-07-01

... information on chemosynthetic communities, federally listed threatened or endangered species, marine mammals protected under the Marine Mammal Protection Act (MMPA), sensitive underwater features, marine sanctuaries, critical habitat designated under the Endangered Species Act (ESA), or other areas of biological concern...

29 CFR 42.20 - Regional Farm Labor Coordinated Enforcement Committee.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Labor Coordinated Enforcement Committee. (a) Under the leadership of the ESA Regional Administrator... subagencies; (3) Develop a written coordinated enforcement strategy specifying for the region all information... annual coordination plan. This strategy shall include at a minimum all information called for by § 42.8...

Hubble gets revitalised in new Servicing Mission for more and better science!

NASA Astrophysics Data System (ADS)

2002-02-01

As a unique collaboration between the European Space Agency (ESA), and NASA, Hubble has had a phenomenal scientific impact. The unsurpassed sharp images from this space observatory have penetrated into the hidden depths of space and revealed breathtaking phenomena. But Hubble's important contributions to science have only been possible through a carefully planned strategy to service and upgrade Hubble every two or three years. ESA, the European Space Agency has a particular role to play in this Servicing Mission. One of the most exciting events of this mission will come when the ESA-built solar panels are replaced by newer and more powerful ones. The new panels, developed in the US, are equipped with ESA developed drive mechanisms and were tested at the facilities at ESA's European Space Research and Technology Centre (ESTEC) in the Netherlands. This facility is the only place in the world where such tests can be performed. According to Ton Linssen, HST Project Manager at ESA, who supervised all ESA involvement in the new solar panels development including the test campaign at Estec - "a particularly tense moment occurs when the present solar panels have to be rolled up to fit into the Shuttle's cargo bay. The hard environment of space has taken its toll on the panels and it will be a very delicate operation to roll them up. Our team will be waiting and watching with bated breath. If the panels can't be rolled up they will possibly have to be left in space." "With this Servicing Mission Hubble is once again going to be brought back to the frontline of scientific technology", says Piero Benvenuti, Hubble Project Scientist at ESA. "New super-advanced instrumentation will revitalise the observatory. For example, Hubble's new digital camera - The new Advanced Camera for Surveys, or ACS - can take images of twice the area of the sky and with five times the sensitivity of Hubble's previous instruments, therefore increasing by ten times Hubble's discovery capability! The European astronomers look forward to use the new camera and perform new science building on the great breakthroughs they have already achieved." ACS is going to replace the Faint Object Camera, or FOC, built by ESA. The FOC, which has functioned perfectly since the beginning, has been a key instrument to get the best out of the unprecedented imaging capability of Hubble. The FOC was a "state-of-the art" instrument in the 80s, but the field of digital imaging has progressed so much in the past 20 years that, having fulfilled its scientific goals, this ESA flagship on Hubble is chivalrously giving way to newer technology. However, the story of FOC is not over yet: experts will still learn from it, as it will be brought back to Earth and inspected, to study the effects on the hardware of the long duration exposure in space. Hubble is expected to continue to explore the sky during the next decade, after which its work will be taken over by its successor, the powerful ESA/NASA/CSA(*) Next Generation Space Telescope. NGST's main focus will be observations of the faint infrared light from the first stars and galaxies in the Universe. Notes for editors The Hubble Space Telescope is a project of international co-operation between ESA and NASA. It was launched in 1990. The partnership agreement between ESA and NASA was signed on 7 October 1977; as a result of this agreement European astronomers have guaranteed access to more than 20% of Hubble's observing time. Astronauts have already paid visits to Hubble in 1993, '97, '99 and now, in the spring of 2002, it is time for the fourth Servicing Mission (named Servicing Mission 3B), planned for launch on 28th February. Originally planned as one mission, the third Servicing Mission was split into two parts (Servicing Mission 3A and 3B) because of the sheer number of tasks to be carried out and the urgency with which Hubble's gyroscopes had to be replaced in late '99. In addition to the new solar panels and the ACS camera, astronauts will install a very high-tech cooling system for Hubble's infrared camera, NICMOS. NICMOS has been dormant since 1999 when it ran out of coolant. The new cooling system is a mechanical cooler, and works like an advanced refrigerator. Servicing Mission 3B will also include other maintenance tasks. Altogether five extensive space walks are planned.

The Nature and Variability of Ensemble Sensitivity Fields that Diagnose Severe Convection

NASA Astrophysics Data System (ADS)

Ancell, B. C.

2017-12-01

Ensemble sensitivity analysis (ESA) is a statistical technique that uses information from an ensemble of forecasts to reveal relationships between chosen forecast metrics and the larger atmospheric state at various forecast times. A number of studies have employed ESA from the perspectives of dynamical interpretation, observation targeting, and ensemble subsetting toward improved probabilistic prediction of high-impact events, mostly at synoptic scales. We tested ESA using convective forecast metrics at the 2016 HWT Spring Forecast Experiment to understand the utility of convective ensemble sensitivity fields in improving forecasts of severe convection and its individual hazards. The main purpose of this evaluation was to understand the temporal coherence and general characteristics of convective sensitivity fields toward future use in improving ensemble predictability within an operational framework.The magnitude and coverage of simulated reflectivity, updraft helicity, and surface wind speed were used as response functions, and the sensitivity of these functions to winds, temperatures, geopotential heights, and dew points at different atmospheric levels and at different forecast times were evaluated on a daily basis throughout the HWT Spring Forecast experiment. These sensitivities were calculated within the Texas Tech real-time ensemble system, which possesses 42 members that run twice daily to 48-hr forecast time. Here we summarize both the findings regarding the nature of the sensitivity fields and the evaluation of the participants that reflects their opinions of the utility of operational ESA. The future direction of ESA for operational use will also be discussed.

Improving accessibility and discovery of ESA planetary data through the new planetary science archive

NASA Astrophysics Data System (ADS)

Macfarlane, A. J.; Docasal, R.; Rios, C.; Barbarisi, I.; Saiz, J.; Vallejo, F.; Besse, S.; Arviset, C.; Barthelemy, M.; De Marchi, G.; Fraga, D.; Grotheer, E.; Heather, D.; Lim, T.; Martinez, S.; Vallat, C.

2018-01-01

The Planetary Science Archive (PSA) is the European Space Agency's (ESA) repository of science data from all planetary science and exploration missions. The PSA provides access to scientific data sets through various interfaces at http://psa.esa.int. Mostly driven by the evolution of the PDS standards which all new ESA planetary missions shall follow and the need to update the interfaces to the archive, the PSA has undergone an important re-engineering. In order to maximise the scientific exploitation of ESA's planetary data holdings, significant improvements have been made by utilising the latest technologies and implementing widely recognised open standards. To facilitate users in handling and visualising the many products stored in the archive which have spatial data associated, the new PSA supports Geographical Information Systems (GIS) by implementing the standards approved by the Open Geospatial Consortium (OGC). The modernised PSA also attempts to increase interoperability with the international community by implementing recognised planetary science specific protocols such as the PDAP (Planetary Data Access Protocol) and EPN-TAP (EuroPlanet-Table Access Protocol). In this paper we describe some of the methods by which the archive may be accessed and present the challenges that are being faced in consolidating data sets of the older PDS3 version of the standards with the new PDS4 deliveries into a single data model mapping to ensure transparent access to the data for users and services whilst maintaining a high performance.

The role of scientists in statutory interpretation of the U.S. Endangered Species Act.

PubMed

Wilhere, George F

2017-04-01

Like many federal statutes, the U.S. Endangered Species Act (ESA) contains vague or ambiguous language. The meaning imparted to the ESA's unclear language can profoundly impact the fates of endangered and threatened species. Hence, conservation scientists should contribute to the interpretation of the ESA when vague or ambiguous language contains scientific words or refers to scientific concepts. Scientists need to know at least these 2 facts about statutory interpretation: statutory interpretation is subjective and the potential influence of normative values results in different expectations for the parties involved. With the possible exception of judges, all conventional participants in statutory interpretation are serving their own interests, advocating for their preferred policies, or biased. Hence, scientists can play a unique role by informing the interpretative process with objective, policy-neutral information. Conversely, scientists may act as advocates for their preferred interpretation of unclear statutory language. The different roles scientists might play in statutory interpretation raise the issues of advocacy and competency. Advocating for a preferred statutory interpretation is legitimate political behavior by scientists, but statutory interpretation can be strongly influenced by normative values. Therefore, scientists must be careful not to commit stealth policy advocacy. Most conservation scientists lack demonstrable competence in statutory interpretation and therefore should consult or collaborate with lawyers when interpreting statutes. Professional scientific societies are widely perceived by the public as unbiased sources of objective information. Therefore, professional scientific societies should remain policy neutral and present all interpretations of unclear statutory language; explain the semantics and science both supporting and contradicting each interpretation; and describe the potential consequences of implementing each interpretation. A review of scientists' interpretations of the phrase "significant portion of its range" in the ESA is used to critique the role of scientists and professional societies in statutory interpretation. © 2016 Society for Conservation Biology.

Near-critical fluids under microgravity : status of the eseme program and perspectives for the iss

NASA Astrophysics Data System (ADS)

Beysens, D.; Garrabos, Y.

2001-03-01

Started 16 years ago, the ESEME program has led to a number of important findings. We note a simple and unified view of phase transitions, which has been applied to the development of biological patterns, and a very fast thermalization mode that we coined the "piston effect". This effect has been applied to control the cryogenic reservoirs of the Ariane 5 rocket. All these findings have been obtained thanks to the good coordination of the ESA and CNES space facilities and the construction of high technology experimental modules. The future of the program is linked to the CNES DECLIC facility and the ESA Fluid Science Laboratory (FSL). DECLIC has been designed to increase the temperature regulation above the critical point of water (550 K) so as to investigate chemical reactions under conditions of supercritical water, and in relation to the promising applications of waste treatment by supercritical oxidation. Thanks to the construction of a special vibrational Experiment Container for FSL, the thermal and mechanical behavior of fluids under forced vibration can be investigated. The results of such studies will help to estimate the effect of g-jitter on fluids, and control gases and liquids in space.

Towards A Moon Village: Vision and Opportunities

NASA Astrophysics Data System (ADS)

Foing, Bernard

2016-04-01

The new DG of ESA, Jan Wörner, has expressed from the very beginning of his duty a clear ambition towards a Moon Village, where Europe could have a lead role. The concept of Moon Village is basically to start with a robotic lunar village and then develop a permanent station on the Moon with different countries and partners that can participate and contribute with different elements, experiments, technologies, and overall support. ESA's DG has communicated about this programme and invited inputs from all the potential stakeholders, especially member states, engineers, industry, scientists, innovators and diverse representatives from the society. In order to fulfill this task, a series of Moon Village workshops have been organized first internally at ESA and then at international community events, and are also planned for the coming months, to gather stakeholders to present their ideas, their developments and their recommendations on how to put Moon Village into the minds of Europeans, international partners and prepare relevant actions for upcoming International Lunar Decade. Moon Village Workshop: The Moon Village Workshop in ESTEC on the 14th December was organized by ILEWG & ESTEC Staff Association in conjunction with the Moon 2020-2030 Symposium. It gathered people coming from all around the world, with many young professionals involved, as well as senior experts and representatives, with a very well gender balanced and multidisciplinary group. Engineers, business experts, managers, scientists, architects, artists, students presented their views and work done in the field of Lunar Exploration. Participants included colleagues from ESA, SGAC Space Generation Advisory Council, NASA, and industries such as OHB SE, TAS, Airbus DS, CGI, etc… and researchers or students from various Universities in Europe, America, and Asia. Working groups include: Moon Habitat Design, Science and Technology potentials on the Moon Village, and Engaging Stakeholders. The Moon Habitat Design group discussed principles and concepts for a minimum base that would start with 4-10 crew, allowing a later evolution to 50 crew and elements contributed by Moon Village partners at large. Various aspects were assessed including habitats, laboratories, EVAs, pressurized vehicles, core modules, inflatable extensions, power systems, life support systems and bioreactors, ISRU using regolith, emergency, services, medical, escape, shelters. The Science and Technology group analyzed the importance and readiness level of technologies needed for lunar robotic landers and for the Moon Village. The current ESA lunar exploration activities focus on the contribution within ISS operations barter of the ESA service module to bring Orion capsule to the Moon starting with an automatic demonstration in 2018. It is encouraged to consolidate this path for using the ser-vice module for crewed missions EM2 and EM3 giving also the possibility of an ESA astronaut, together with advanced technology, operations and science utilization. They noted the interesting contribution of instruments, drill, communications, and landing in support to Russian lunar polar lander missions Luna 27. The Engaging Stakeholders working group started by identifying the main stakeholders and groups that play a role or that could play a role towards the Moon Village project. These stakeholders were classified on their influence towards the programme, and their attitude towards it. One clear conclusion was that most of the stakeholders showed a positive view towards the Moon Village programme, and that the most important step within a short term strategy should focus on the actions to be taken to engage stakeholders for the next ESA Ministerial to support the programme. Finally the group came up with some recommendations on which should be the actions to be taken by the ESA DG to engage the most direct stakeholders: ESA delegations, media, national governments, citizens, taxpayers, and to invite partners. Building on previous studies (EuroMoon, lunar polar lander) ESA should develop a mid-class lunar lander (affordable in cost 300 Meu class), demonstrating the expertise at system level for a platform, that could carry innovative competitive robotic payload contributed and already with advance development from member states and international or commercial partners. With teleoperations from Earth and cis-lunar orbit, this will advance progress towards the next steps of Moon Village and beyond. Recommendations: The participants encourage the design and operations of a Moon base simulation at EAC with facility and activities in the context of SpaceShip EAC, with the support of EAC, DLR, ESTEC, ISU and other partners, and collaborations with other Lunar Research Parks worldwide. It was also proposed to have an "ESTEC Moon Village pilot project" where 20 young professional in-terns could be hosted to work concurrently on various aspects (technology, science, instruments platforms, Moon base design, human factors, programmatics, outreach, community events) with links and support activities from ESTEC senior experts, and interactions with colleagues in member states, academia and industries . The workshop finalized with some hands-on experiments, organized with some students demonstrating their work on a lunar lander with tele-operated instruments and systems, and on the measuring spectra of Moon-Mars analogue minerals. The day ended with a refreshing lunar music session, and a networking event on ESTEC ESCAPE where the last informal conversations marked a great wrap up of such exciting day. Follow up Moon Village events are planned in 2016 at ESTEC, EAC and at international community venues. New means of outreach, communications and social media must be developed. You can follow Moon Village tweets, using #MoonVillage, and contribute to the virtual discussions. ESA is really looking forward to engage all stakeholders into the discussion, no matter of their background, nationality or interest. Just let us know your views! Highlights and recommendations can be found on https://ildwg.wordpress.com/ *Moon Village Workshops Organisers Team: Bernard Foing (ESA/ESTEC & ILEWG), Aidan Cowley, Guillermo Ortega, Linda van Hilten (ESA), Vid Beldavs, David Dunlop, Jim Crisafulli (International Lunar Decade), ESTEC Moon Village workshop 2015 WGs co-conveners: Peter Batenburg, Andrea Jaime, Abigail Calzada, Angeliki Kapoglou, Chris Welch, Susanne Pieterse, Daniel Esser, Audrey Berquand, Daniel Winter, Dmitri Ivanov, Simone Paternostro, Matias Hazadi, Oscar Kamps, Marloes Offringa

ESA achievements: more than thirty years of pioneering space activity

NASA Astrophysics Data System (ADS)

Wilson, Andrew

2005-06-01

Contents: ESA and science. ESA and Earth observation (Explorer Core missions, Explorer opportunity missions, Earth Watch). ESA and telecommunications. ESA and navigation. ESA and launchers. ESA and manned spaceflight. The ESA Science Programme is one of the Agency's mandatory activities, in which all Member States participate. The origins of the Science Programme, the oldest in the Agency, hark back to the days of ESRO. ESRO's seven successful scientific satellites paved the way for ESA's remarkable series of pioneering missions that have placed Europe at the vanguard of disciplines such as X-ray, gamma-ray and infrared astronomy; astrometry; solar system sciences (especially cometary), solar and heliospheric physics, as well as space plasma physics. Driven by the limited available means, ESA's Science Programme has consistently focused on missions with strong innovative contents. All of the missions launched or approved so far are covered in separate entries in this volume.

78 FR 27187 - Proposed Information Collection; Comment Request; Green Sturgeon Endangered Species Act Take...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-09

... Collection; Comment Request; Green Sturgeon Endangered Species Act Take Exceptions and Exemptions AGENCY...) of the Endangered Species Act (ESA) were promulgated for the species on June 2, 2010 (75 FR 30714... information collection, as required by the Paperwork Reduction Act of 1995. DATES: Written comments must be...

PASCAL Data Base: File Description and On Line Access on ESA/IRS.

ERIC Educational Resources Information Center

Pelissier, Denise

This report describes the PASCAL database, a machine readable version of the French abstract journal Bulletin Signaletique, which allows use of the file for (1) batch and online retrieval of information, (2) selective dissemination of information, and (3) publishing of the 50 sections of Bulletin Signaletique. The system, which covers nine…

77 FR 6861 - Proposed Collection; Comment Request for Form 5498-ESA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-09

... 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning... the collection of information displays a valid OMB control number. Books or records relating to a... administration of any internal revenue law. Generally, tax returns and tax return information are confidential...

30 CFR 550.223 - What mitigation measures information must accompany the EP?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What mitigation measures information must accompany the EP? 550.223 Section 550.223 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... under the ESA; and (2) Marine mammals, as appropriate, if you have not already received authorization...

30 CFR 250.254 - What mitigation measures information must accompany the DPP or DOCD?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What mitigation measures information must accompany the DPP or DOCD? 250.254 Section 250.254 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT... take of: (1) Threatened and endangered species listed under the ESA and (2) Marine mammals, as...

30 CFR 550.223 - What mitigation measures information must accompany the EP?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What mitigation measures information must accompany the EP? 550.223 Section 550.223 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... under the ESA; and (2) Marine mammals, as appropriate, if you have not already received authorization...

30 CFR 550.223 - What mitigation measures information must accompany the EP?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What mitigation measures information must accompany the EP? 550.223 Section 550.223 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF... under the ESA; and (2) Marine mammals, as appropriate, if you have not already received authorization...

30 CFR 250.223 - What mitigation measures information must accompany the EP?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What mitigation measures information must accompany the EP? 250.223 Section 250.223 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION... endangered species listed under the ESA and (2) Marine mammals, as appropriate, if you have not already...

76 FR 70748 - Proposed Information Collection; Policy for Evaluation of Conservation Efforts When Making...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-15

...-FXES11170900000-B3] Proposed Information Collection; Policy for Evaluation of Conservation Efforts When Making... under the ESA. The Policy for Evaluation of Conservation Efforts When Making Listing Decisions (PECE... contributes to forming a basis for making a decision about the listing of a species. PECE applies to...

The Information Needs of Scientists and Engineers in Aerospace.

ERIC Educational Resources Information Center

Raitt, D. I.

The information seeking and use habits of more than 600 scientists and engineers on staff at the European Space Agency (ESA) were studied and compared with those of staff at five European organizations with similar missions: the United Nations Education, Scientific, and Cultural Organization (UNESCO) in France; the International Atomic Energy…

Planck satellite to be presented to media

NASA Astrophysics Data System (ADS)

2007-01-01

Planck will make the most accurate maps yet of the microwave background radiation that fills space. It will be sensitive to temperature variations of a few millionths of a degree and will map the full sky in nine wavelengths. The immediate outcome of the Big Bang and the initial conditions for the evolution in the universe’s structure are the primary target of this important mission. From the results, a great deal more will be learnt not only about the nature and amount of dark matter, the ‘missing mass’ of the universe, but also about the nature of dark energy and the expansion of the universe itself. To address such challenging objectives, Planck will need to operate at very low, stable temperatures. Once in space, its detectors will have to be cooled to temperature levels close to absolute zero (-273.15ºC), ranging from -253ºC to only a few tenths of a degree above absolute zero. The Planck spacecraft thus has to be a marvel of cryotechnology. After integration, Planck will start a series of tests that will continue into early-2008. It will be launched by end-July 2008 in a dual-launch configuration with Herschel, ESA’s mission to study the formation of galaxies, stars and planetary systems in the infrared. Interested media are invited to fill in the reply form below. Note to editors The Planck spacecraft was built by AAS Cannes, the prime contractor, leading a consortium of industrial partners with the AAS industry branch in Turin, Italy, responsible for the satellite’s service module. ESA and the Danish National Space Centre (Copenhagen, Denmark) are responsible for the hardware provision of Planck’s telescope mirrors, manufactured by EADS Astrium (Friedrichshafen, Germany). AAS Cannes is also responsible for the payload module, the platform that hosts the telescope and the two onboard instruments, HFI and LFI. The instruments themselves are being supplied by a consortium of scientists and institutes led by the Institut d'Astrophysique Spatiale at Orsay (France) in the case of HFI, and by the Istituto di Astrofisica Spaziale e Fisica Cosmica (IASF) in Bologna (Italy) in that of LFI. There are also numerous subcontractors spread throughout Europe, with several more in the USA. For further information, please contact: ESA Media Relations Office Tel: +33(0)1.53.69.7155 Fax: +33(0)1.53.69.7690 Press event programme 1 February 2007, 10:00 am Alcatel Alenia Space 100 Boulevard du Midi, Cannes (France) 10:00 - 10:05 - Opening address, by Patrick Maute - Head of Optical Observation and Science Programmes - Alcatel Alenia Space, and by Jacques Louet - Head of Science Projects - ESA 10:05 - 10:15 - Herschel/Planck Mission overview, by Thomas Passvogel - Planck Project Manager - ESA 10:15 - 10:25 - Planck satellite, by Jean-Jacques Juillet - Programme Manager - Alcatel Alenia Space 10:25 - 10:35 - The scientific mission, by Jan Tauber - Planck Project Scientist - ESA 10:35 - 10:45 - The High-Frequency Instrument, by Jean-Loup Puget - HFI Principal Investigator 10:45 - 10:55 - The Low-Frequency Instrument, by Reno Mandolesi - LFI Principal Investigator 10:55 - 11:05 - Special guest - Nobel prize winner G.F. Smoot 11:05 - 11:25 - Questions and answers 11:25 - 12:35 - Visit of the integration room to see Planck spacecraft and face-to-face interviews 12:45 - 14:30 - Lunch hosted by Alcatel Alenia Space.

Immunization with excreted-secreted antigens reduces tissue cyst formation in pigs.

PubMed

Wang, Yanhua; Zhang, Delin; Wang, Guangxiang; Yin, Hong; Wang, Meng

2013-11-01

It has been demonstrated that tachyzoite-pooled excreted-secreted antigens (ESAs) of Toxoplasma gondii are highly immunogenic and can be used in vaccine development. However, most of the information regarding protective immunity induced by immunization with ESAs is derived from studies using mouse model systems. These results cannot be extrapolated to pigs due to important differences in the susceptibility and immune response mechanisms between pigs and mice. We show that the immunization of pigs with ESAs emulsified in Freund's adjuvant induced not only a humoral immune response but also a cellular response. The cellular immune response was associated with the production of IFN-γ and IL-4. The humoral immune response was mainly directed against the antigens with molecular masses between 34 and 116 kDa. After intraperitoneal challenge with 10(7) T. gondii of the Gansu Jingtai strain (GJS) of tachyzoites, the immunized pigs remained clinically normal except for a brief low-grade fever (≤40.5 °C), while the control pigs developed clinical signs of toxoplasmosis (cough, anorexia, prostration, and high fever). At necropsy, visible lesions were found at multiple locations (enlarged mesenteric lymph nodes, an enlarged spleen with focal necrosis, and enlarged lungs with miliary or focal necrosis and off-white lesions) in all of the control pigs but not in the pigs that had been immunized. We also found that immunization with ESAs reduced tissue cyst formation in the muscle (P < 0.01). Our data demonstrate that immunization with ESAs can trigger a strong immune response against T. gondii infection in pigs.

Methods of Analysis by the U.S. Geological Survey Organic Geochemistry Research Group-Update and Additions to the Determination of Chloroacetanilide Herbicide Degradation Compounds in Water Using High-Performance Liquid Chromatography/Mass Spectrometry

USGS Publications Warehouse

Lee, E.A.; Kish, J.L.; Zimmerman, L.R.; Thurman, E.

2001-01-01

An analytical method using high-performance liquid chromatography/mass spectrometry (HPLC/MS) was developed by the U.S. Geological Survey in 1999 for the analysis of selected chloroacetanilide herbicide degradation compounds in water. These compounds were acetochlor ethane sulfonic acid (ESA), acetochlor oxanilic acid (OXA), alachlor ESA, alachlor OXA, metolachlor ESA, and metolachlor OXA. The HPLC/MS method was updated in 2000, and the method detection limits were modified accordingly. Four other degradation compounds also were added to the list of compounds that can be analyzed using HPLC/MS; these compounds were dimethenamid ESA, dimethenamid OXA, flufenacet ESA, and flufenacet OXA. Except for flufenacet OXA, good precision and accuracy were demonstrated for the updated HPLC/MS method in buffered reagent water, surface water, and ground water. The mean HPLC/MS recoveries of the degradation compounds from water samples spiked at 0.20 and 1.0 ?g/L (microgram per liter) ranged from 75 to 114 percent, with relative standard deviations of 15.8 percent or less for all compounds except flufenacet OXA, which had relative standard deviations ranging from 11.3 to 48.9 percent. Method detection levels (MDL's) using the updated HPLC/MS method varied from 0.009 to 0.045 ?g/L, with the flufenacet OXA MDL at 0.072 ?g/L. The updated HPLC/MS method is valuable for acquiring information about the fate and transport of the parent chloroacetanilide herbicides in water.

KSC-2013-2883

NASA Image and Video Library

2013-06-20

CAPE CANAVERAL, Fla. – Representatives from the European Space Agency, or ESA, toured the Operations and Checkout Building high bay and viewed the Orion crew module at NASA’s Kennedy Space Center in Florida. From the left, are Philippe Deloo, ESA European Service Module Study manager Kathleen Schubert, NASA crew and service module deputy manager Bernardo Patti, ESA manager of International Space Station Operations Mark Geyer, NASA Orion program manager and Ari Blum, NASA export administrator at Johnson Space Center in Houston. Orion is the exploration spacecraft designed to carry crews to space beyond low Earth orbit. It will provide emergency abort capability, sustain the crew during the space travel and provide safe re-entry from deep space return velocities. Orion’s first unpiloted test flight is scheduled to launch in 2014 atop a Delta IV rocket. A second uncrewed flight test is scheduled for 2017 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Jim Grossmann

Huygens landing site to be named after Hubert Curien

NASA Astrophysics Data System (ADS)

2007-03-01

The naming ceremony for the Huygens landing site, which will be known as the "Hubert Curien Memorial Station", will be held at ESA’s Headquarters on 14 March, in the presence of ESA Council delegates and of Professor Curien’s wife, Mrs Perrine Curien, and one of their sons. Media interested in attending are invited to submit the reply form below. Huygens' landing on Saturn’s largest moon in January 2005 represented one of the greatest successes achieved by humankind in the history of space exploration. The part played by ESA, in cooperation with NASA and the Italian Space Agency (ASI), was made possible thanks to the commitment of a man who, for several decades, worked to promote and strengthen the role of scientific research in his home country - France - and in Europe. Among his numerous responsibilities, Hubert Curien was French Minister of Research and Space under four Prime Ministers. As Chairman of the ESA Council from 1981 to 1984, Professor Curien played a crucial part in setting up ESA's former long-term science programme, "Horizon 2000", which included the Huygens mission among its projects. Professor Roger Bonnet, current President of COSPAR, and former ESA Director of Science (1983-2001), commented: "Curien’s diplomatic skills were hugely influential in bringing about the birth of European space science. In 1985, his support was pivotal when the European ministers had to decide how to build a solid space science programme and ensure that it would be financially sustainable in the long term." "ESA's present science programme, Cosmic Vision, draws on the heritage left by Hubert Curien", said Professor David Southwood, ESA's current Director of Science. "He encouraged cooperation between nations in the belief that space research is fundamental to the progress and welfare of a knowledge-based society like ours. He also promoted the concept of long-term planning", he continued. "It would seem almost inconceivable today to initiate any space venture without such pillar concepts in mind". "The role played by Hubert Curien in creating a European space dimension, with all its various facets, has been absolutely essential", said Jean-Jacques Dordain, ESA Director General. "Curien was one of the fathers of the Ariane Programme, which provided Europe with independent access to space, and one of those who, in the late seventies, persuaded other countries to join ESA by creating the 'fair return' system for industrial contracts." Dordain continued, "This exceptional man of vision was appreciated by all for his scientific competence and his outstanding human, political and diplomatic abilities. It is therefore a true honour for us to pay tribute to his memory by linking his name forever to this very significant place on the surface of an alien world that, also thanks to him, we were able to reach." For more information please contact : Franco Bonacina ESA Media Relations Office Communication Department Tel: +33(0)1.53.69.7155 Fax: +33(0)1.53.69.7690 Note for editors Short biography of Hubert Curien Hubert Curien was born on 30 October 1924 in the Vosges region of eastern France. While a student, he enlisted in the French resistance and was commended for bravery in action. He entered the Ecole Normale Supérieure in Paris and went on to pursue a research career in crystallography, joining the Sorbonne Mineralogy Laboratory. He was always keen to encourage collaboration between mineralogists and physicists. He was appointed lecturer at the University of Paris in 1949, obtained his PhD in 1951, and became professeur in 1956. From 1968 onwards, he continued with his teaching career at the 'Pierre et Marie Curie/Paris VI' University, which he left only in 1994, despite all his political duties. Aside from his scientific career, Hubert Curien is known mostly for his managerial and political responsibilities, pursued with commitment, efficiency and vision both in France and in Europe. He left his mark on an impressive number of scientific institutions. From 1966 to 1969, he was Scientific Director for Physics at the CNRS, France's scientific research centre, becoming its Director General in 1969. In 1973, he was given responsibility for reorganising research in France. From 1976 to 1984, he was President of the French space agency (CNES), and from 1984 to1993, served as Minister of Research and Space under four different governments. From 1981 to 1984, he was Chairman of the ESA Council, and he is now still remembered - among his many achievements - as one of the fathers of the Ariane programme and as a promoter of a Europe united through science. From 1994 to 1996, he also headed the European Organization for Nuclear Research (CERN), and in 1993, was elected to the French Academy of Science. For his work, Hubert Curien received the highest distinctions and awards. He was known for his great intelligence and managerial and political abilities, but also for his simplicity, modesty, sense of humour and willingness to listen to others. He died on 6 February 2005, and is survived by his wife, Perrine, and their sons, Nicolas, Christophe and Pierre-Louis. Huygens highlights The European-built Huygens probe was part of the Cassini-Huygens mission to Saturn - a joint endeavour of ESA, NASA and the Italian Space Agency (ASI). It is the most ambitious effort in planetary space exploration ever mounted. Launched on 15 October 1997, Cassini (a sophisticated robotic spacecraft designed to orbit the ringed planet and study the Saturnian system in detail), bearing the Huygens probe, reached Saturn on 1 July 2004. Cassini delivered Huygens to Saturn’s largest moon, Titan, on 14 January 2005. This was the first ever descent and landing onto a celestial body in the outer Solar System, and it provided the most spectacular view of Titan yet. During its 2½-hour descent onto this alien world, Huygens performed a series of measurements by means of its highly advanced suite of six instruments. It detected information about Titan’s atmosphere and winds. It also took remarkable pictures of the approaching surface, up to touchdown, which took place in Titanian 'mud', where, amazingly, it continued to take measurements for more than 3 hours. Now, thanks to the Huygens measurements and also to the complementary, global measurements made by Cassini, we actually know that Titan’s landscapes truly resemble those on Earth, with mountains, lakes, shorelines and outflow channels, where methane plays a role similar to that of water on Earth. By detecting Argon 40, Huygens also helped to reveal that the interior of Titan is still active, as confirmed later by Cassini, which observed icy 'lava' flows emerging from 'cryo-volcanoes'. The Cassini-Huygens results so far tell us that Titan, once thought to resemble an early, frozen Earth, in reality appears to be as complex as any of the terrestrial planets that have an atmosphere. Huygens has exceeded expectations and shown Titan to be an 'alien earth', probably more similar to our own planet than either Mars or Venus, and is enabling planetary scientists to explore a new, fascinating world.

A bioeconomic perspective on the Endangered Species Act

NASA Astrophysics Data System (ADS)

Salau, K. R.; Fenichel, E. P.

2012-12-01

Habitat destruction threatens species existence and has recently accelerated due to population growth, urban sprawl, agricultural development and other profitable land conversions on public and private lands. To exacerbate this issue, the public good nature of species existence creates strong incentives for landowners to engage in free-riding behavior and forego conservation on managed lands. To reverse these negative effects, the United States Congress passed the Endangered Species Act (ESA) in 1973 to create a set of rules for planning government intervention to protect dwindling fish, wildlife, and plant populations and create a platform for recovery and conservation. The ESA is quite explicit about how to make tradeoffs when listing a species as threatened or endangered - only evaluation of biological risks faced are considered. But the act is unclear about what information can or should be used when determining delisting criteria for endangered species. The ESA mandates federal participation in conservation and, in many cases, agencies must curtail socially beneficial activities (e.g. grazing, renewable energy development, mining, military training) in order to meet species recovery objectives. As funding for conservation on federal lands is limited, this creates an implicit tradeoff between recovering species - to gain post-delisting managerial flexibility - and preventing extinction - to minimize management costs. In this respect, reconciliation of biological recovery goals amidst budget constraints and alternate land-use benefits should be supplemented by economic analysis. Economic tradeoffs are inherent in species recovery under the ESA, but the act does not discuss how agencies should structure a recovery plan in light of such factors. This study outlines a bioeconomic approach to framing the recovery problem under the ESA and provides a framework for simultaneously establishing measurable delisting criteria and a least-cost path to recovery. This approach is also a helpful conceptual tool for evaluating instruments like the ESA on their ability to provide conservation at a socially desired level, absent strong market incentive.

Climate change, marine environments, and the US Endangered species act.

PubMed

Seney, Erin E; Rowland, Melanie J; Lowery, Ruth Ann; Griffis, Roger B; McClure, Michelle M

2013-12-01

Climate change is expected to be a top driver of global biodiversity loss in the 21st century. It poses new challenges to conserving and managing imperiled species, particularly in marine and estuarine ecosystems. The use of climate-related science in statutorily driven species management, such as under the U.S. Endangered Species Act (ESA), is in its early stages. This article provides an overview of ESA processes, with emphasis on the mandate to the National Marine Fisheries Service (NMFS) to manage listed marine, estuarine, and anadromous species. Although the ESA is specific to the United States, its requirements are broadly relevant to conservation planning. Under the ESA, species, subspecies, and "distinct population segments" may be listed as either endangered or threatened, and taking of most listed species (harassing, harming, pursuing, wounding, killing, or capturing) is prohibited unless specifically authorized via a case-by-case permit process. Government agencies, in addition to avoiding take, must ensure that actions they fund, authorize, or conduct are not likely to jeopardize a listed species' continued existence or adversely affect designated critical habitat. Decisions for which climate change is likely to be a key factor include: determining whether a species should be listed under the ESA, designating critical habitat areas, developing species recovery plans, and predicting whether effects of proposed human activities will be compatible with ESA-listed species' survival and recovery. Scientific analyses that underlie these critical conservation decisions include risk assessment, long-term recovery planning, defining environmental baselines, predicting distribution, and defining appropriate temporal and spatial scales. Although specific guidance is still evolving, it is clear that the unprecedented changes in global ecosystems brought about by climate change necessitate new information and approaches to conservation of imperiled species. El Cambio Climático, los Ecosistemas Marinos y el Acta Estadunidense de Especies en Peligro. © 2013 Society for Conservation Biology.

Hubble's deepest view ever of the Universe unveils earliest galaxies

NASA Astrophysics Data System (ADS)

2004-03-01

Hubble sees galaxies galore hi-res Size hi-res: 446 kb Credits: NASA, ESA, and S. Beckwith (STScI) and the HUDF Team Hubble sees galaxies galore Galaxies, galaxies everywhere - as far as the NASA/ESA Hubble Space Telescope can see. This view of nearly 10,000 galaxies is the deepest visible-light image of the cosmos. Called the Hubble Ultra Deep Field, this galaxy-studded view represents a ‘deep’ core sample of the universe, cutting across billions of light-years. Hubble reveals galactic drama hi-res Size hi-res: 879 kb Credits: NASA, ESA, and S. Beckwith (STScI) and the HUDF Team Hubble reveals galactic drama A galactic brawl. A close encounter with a spiral galaxy. Blue wisps of galaxies. These close-up snapshots of galaxies in the Hubble Ultra Deep Field reveal the drama of galactic life. Here three galaxies just below centre are enmeshed in battle, their shapes distorted by the brutal encounter. Hubble reveals galactic drama hi-res Size hi-res: 886 kb Credits: NASA, ESA, and S. Beckwith (STScI) and the HUDF Team Hubble reveals galactic drama A galactic brawl. A close encounter with a spiral galaxy. Blue wisps of galaxies. These close-up snapshots of galaxies in the Hubble Ultra Deep Field reveal the drama of galactic life. Here three galaxies just below centre are enmeshed in battle, their shapes distorted by the brutal encounter. Hubble reveals galactic drama hi-res Size hi-res: 892 kb Credits: NASA, ESA, and S. Beckwith (STScI) and the HUDF Team Hubble reveals galactic drama A galactic brawl. A close encounter with a spiral galaxy. Blue wisps of galaxies. These close-up snapshots of galaxies in the Hubble Ultra Deep Field reveal the drama of galactic life. The galaxies in this panel were plucked from a harvest of nearly 10,000 galaxies in the Ultra Deep Field, the deepest visible-light image of the cosmos. This historic new view is actually made up by two separate images taken by Hubble's Advanced Camera for Surveys (ACS) and the Near Infrared Camera and Multi-object Spectrometer (NICMOS). Both images reveal some galaxies that are too faint to be seen by ground-based telescopes, or even in Hubble's previous faraway looks, called the Hubble Deep Fields (HDFs), taken in 1995 and 1998. The HUDF field contains an estimated 10,000 galaxies in a patch of sky just one-tenth the diameter of the full Moon. Besides the rich harvest of classic spiral and elliptical galaxies, there is a zoo of oddball galaxies littering the field. Some look like toothpicks; others like links on a bracelet. A few appear to be interacting. Their strange shapes are a far cry from the majestic spiral and elliptical galaxies we see today. These oddball galaxies chronicle a period when the Universe was more chaotic. Order and structure were just beginning to emerge. The combination of ACS and NICMOS images will be used to search for galaxies that existed between 400 and 800 million years after the Big Bang (in cosmological terms this corresponds to a 'redshift' range of 7 to 12). Astronomers around the world will use these data to understand whether in this very early stages the Universe appears to be the same as it did when the cosmos was between 1000 and 2000 million years old. Hubble's ACS allows astronomers to see galaxies two to four times fainter than Hubble could view previously, but the NICMOS sees even farther than the ACS. The NICMOS reveals the farthest galaxies ever seen because the expanding Universe has stretched their light into the near-infrared portion of the spectrum. The ACS uncovered galaxies that existed 800 million years after the Big Bang (at a redshift of 7). But the NICMOS might have spotted galaxies that lived just 400 million years after the birth of the cosmos (at a redshift of 12). Just like the previous HDFs, the new data are expected to galvanise the astronomical community and lead to dozens of research papers that will offer new insights into the birth and evolution of galaxies. This will hold the record as the deepest-ever view of the Universe until ESA together with NASA launches the James Webb Space Telescope in 2011. Notes for editors More information, images, animations and interactive zoomable images are available from http://www.spacetelescope.org/news/html/heic0406.html The Hubble Space Telescope is a project of international cooperation between ESA and NASA. Image credit: NASA, ESA, S. Beckwith (STScI) and the HUDF Team

NASA and ESA astronauts visit ESO. Hubble repair team meets European astronomers in Garching.

NASA Astrophysics Data System (ADS)

1994-02-01

On Wednesday, February 16, 1994, seven NASA and ESA astronauts and their spouses will spend a day at the Headquarters of the European Southern Observatory. They are the members of the STS-61 crew that successfully repaired the Hubble Space Telescope during a Space Shuttle mission in December 1993. This will be the only stop in Germany during their current tour of various European countries. ESO houses the Space Telescope European Coordinating Facility (ST/ECF), a joint venture by the European Space Agency and ESO. This group of astronomers and computer specialists provide all services needed by European astronomers for observations with the Space Telescope. Currently, the European share is about 20 of the total time available at this telescope. During this visit, a Press Conference will be held on Wednesday, February 16, 11:45 - 12:30 at the ESO Headquarters Karl-Schwarzschild-Strasse 2 D-85748 Garching bei Munchen. Please note that participation in this Press Conference is by invitation only. Media representatives may obtain invitations from Mrs. E. Volk, ESO Information Service at this address (Tel.: +49-89-32006276; Fax.: +49-89-3202362), until Friday, February 11, 1994. After the Press Conference, between 12:30 - 14:00, a light refreshment will be served at the ESO Headquarters to all participants. >From 14:00 - 15:30, the astronauts will meet with students and teachers from the many scientific institutes in Garching in the course of an open presentation at the large lecture hall of the Physics Department of the Technical University. It is a 10 minute walk from ESO to the hall. Later the same day, the astronauts will be back at ESO for a private discussion of various space astronomy issues with their astronomer colleagues, many of whom are users of the Hubble Space Telescope, as well as ground-based telescopes at the ESO La Silla Observatory and elsewhere. The astronauts continue to Switzerland in the evening.

Priorities in national space strategies and governance of the member states of the European Space Agency

NASA Astrophysics Data System (ADS)

Adriaensen, Maarten; Giannopapa, Christina; Sagath, Daniel; Papastefanou, Anastasia

2015-12-01

The European Space Agency (ESA) has twenty Member States with a variety of strategic priorities and governance structures regarding their space activities. A number of countries engage in space activities exclusively though ESA, while others have also their own national space programme. Some consider ESA as their prime space agency and others have additionally their own national agency with respective programmes. The main objective of this paper is to provide an up-to date overview and a holistic assessment of strategic priorities and the national space governance structures in 20 ESA Member States. This analysis and assessment has been conducted by analysing the Member States public documents, information provided at ESA workshop on this topic and though unstructured interviews. The paper is structured to include two main elements: priorities and trends in national space strategies and space governance in ESA Member States. The first part of this paper focuses on the content and analysis of the national space strategies and indicates the main priorities and trends in Member States. The priorities are categorised with regards to technology domains, the role of space in the areas of sustainability and the motivators that boost engagement in space. These vary from one Member State to another and include with different levels of engagement in technology domains amongst others: science and exploration, navigation, Earth observation, human space flight, launchers, telecommunications, and integrated applications. Member States allocate a different role of space as enabling tool adding to the advancement of sustainability areas including: security, resources, environment and climate change, transport and communication, energy, and knowledge and education. The motivators motivating reasoning which enhances or hinders space engagement also differs. The motivators identified are industrial competitiveness, job creation, technology development and transfer, social benefits, international cooperation, and European non-dependence. The second part of the paper provides a categorisation of national space governance structures in ESA Member States. Different governance models are identified depending on the responsible ministries for space for a number of space related organisations and ESA. In the case of ESA, these can typically vary from the more traditional ministry of science and/or education, the ministry of industry and/or innovation to the more recent ones being the ministry of economy and the ministry of transport. Recognising the transverse nature of space and its potential as a tool for a number of policies like agriculture, environment, maritime, disaster management, etc., other ministries are more and more getting involved in space activities. The development and implementation of the space strategy and policy of a Member State is realised though the engagement of an implementing entity. The type, role and activity vary from Member State to Member State.

30 CFR 550.254 - What mitigation measures information must accompany the DPP or DOCD?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 2 2014-07-01 2014-07-01 false What mitigation measures information must accompany the DPP or DOCD? 550.254 Section 550.254 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT... and endangered species listed under the ESA; and (2) Marine mammals, as appropriate, if you have not...

30 CFR 550.254 - What mitigation measures information must accompany the DPP or DOCD?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 2 2013-07-01 2013-07-01 false What mitigation measures information must accompany the DPP or DOCD? 550.254 Section 550.254 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT... and endangered species listed under the ESA; and (2) Marine mammals, as appropriate, if you have not...

30 CFR 550.254 - What mitigation measures information must accompany the DPP or DOCD?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 2 2012-07-01 2012-07-01 false What mitigation measures information must accompany the DPP or DOCD? 550.254 Section 550.254 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT... and endangered species listed under the ESA; and (2) Marine mammals, as appropriate, if you have not...

Huygens space probe ready to leave Europe

NASA Astrophysics Data System (ADS)

1997-03-01

Over the past year, the Huygens probe has been integrated and extensively tested at the facilities of Daimler Benz Aerospace Dornier Satellitensysteme in Ottobrunn near Munich. It was designed and developed for ESA by a European industrial consortium led by Aerospatiale (F) as prime contractor. The European activities have been successfully completed and this is to be formalised by the Flight Acceptance Review which will release the probe for shipment to the USA. To mark this important milestone a press briefing is scheduled for Wednesday, 26 March at 10.00 hours at Daimler-Benz Aerospace Dornier Satellitensysteme in Ottobrunn. The detailed programme of the press briefing is attached. If you wish to attend the press briefing, please complete the attached accreditation form and return it, preferably by fax, to : Daimler Benz Aerospace Dornier Satellitensysteme Mr. Mathias Pikelj, Fax. + 49 7545 8 5589, Tel. + 49 7545 8 9123 NOTE FOR THE EDITORS: Background facts about the Cassini Huygens mission Huygens is a medium-sized mission of ESA's Horizons 2000 programme for space science, and a contribution to the joint NASA ESA Cassini mission. Christiaan Huygens discovered Saturn s moon Titan in 1655, and the mission named after him aims to land a 343 kilogram probe on Titan carrying a package of scientific instruments through the atmosphere. Six sets of instruments will analyse the chemical composition of the atmosphere, observe the weather and topography of Titan, and examine the nature of its surface. Titan is larger than the planet Mercury, and its unique atmosphere, rich in nitrogen and hydrocarbons, may resemble the atmosphere of the primitive Earth, before life began. Nominal dates for the Huygens mission are as follows: * launch, 6 October 1997 * arrival at Saturn, 1 July 2004 * release of Huygens, 6 November 2004 * entry into Titan's atmosphere, 27 November 2004. The Saturn Orbiter, the other element in the Cassini mission, will relay the signals from Huygens to the Earth, before settling down to prolonged observations of Saturn and its rings and moons. European and American scientists are partners in all the experiments, both in the Orbiter and in the Huygens Probe. Farthest out for Europe Huygens will travel to a greater distance from the Sun than any previous ESA mission, out to the orbit of Saturn at 1400 million kilometres, or nearly ten times the Sun Earth distance. For comparison, the farthest ranging mission at present is Ulysses, orbiting over the poles of the Sun and out to the orbit of Jupiter, 800 million kilometres from the Sun. As no other mission planned or contemplated by ESA at present will go as far as Saturn, Huygens is likely to hold the European record for many years. HUYGENS READY TO LEAVE EUROPE PRESS BRIEFING Wednesday 26 March, 10:00 hrs. Location : Daimler-Benz Aerospace/ Dornier Satellitensysteme Gate 2, Building 5.1 Ludwig-B>lkow-Allee Ottobrunn (Munich) Programme: 10h00 Registration of press 10h15 Huygens video introduction 10h20 Welcoming addresses: Klaus Ensslin, President, Dornier Satellitensysteme Roger Bonnet, Director of Science, ESA Michel Delaye, President, Aerospatiale Espace & Defense 10h30 NASA News and Cassini status Wesly T. Huntress, Associate Administrator of Space Science, NASA Richard Spehalski, Head of Cassini Project, NASA/JPL 10h40 The Huygens Project: Hamid Hassan, Head of the Huygens Project, ESA/ESTEC Hans-Joachim Hoffman, Head of the Huygens Project, Dornier Satellitensysteme Gerard Huttin, Head of the Huygens Project, Aerospatiale 11h00 The Huygens Scientific Programme: Jean-Pierre Lebreton, Huygens Project Scientist, ESA supported by European and American scientists. 11h15 The ESA Science programme, current and future missions Roger Bonnet, Director of Science, ESA 11h25 Question and Answer session 11h55 Visit to the Huygens spacecraft (access inside the clean room limited to photographers and TV teams only). 12h45 Buffet lunch 14h00 End of activties HUYGENS READY TO LEAVE EUROPE PRESS BRIEFING Wednesday 26 March, 10:00 hrs. Location : Daimler-Benz Aerospace/ Dornier Satellitensysteme Gate 2, Building 5.1 Ludwig-B>lkow-Allee Ottobrunn (Munich)

Iodine Plasma Species Measurements in a Hall Effect Thruster Plume

DTIC Science & Technology

2013-05-01

with an ExB probe , an electrostatic analyzer (ESA), and a combined ESA/ExB probe . The distribution of xenon ions was also measured. Multiply charge...of iodine ions was measured with an ExB probe , an electrostatic analyzer (ESA), and a combined ESA/ExB probe . • Results: – Multiply charged species...Test Hardware – Vacuum test facility (6’ diameter) – Faraday probe (MIT) – ESA, ExB, ESA/ExB Probes (Plasma Controls) – Rotary probe arm (about

Formation and transport of the sulfonic acid metabolites of alachlor and metolachlor in soil

USGS Publications Warehouse

Aga, D.S.; Thurman, E.M.

2001-01-01

Alachlor and metolachlor are dechlorinated and transformed into their corresponding ethane sulfonic acid (ESA) metabolites in soil. In a field-disappearance study, it was shown that alachlor ESA was formed at a faster rate and at concentrations 2-4 times higher than metolachlor ESA, conforming with the observed longer disappearance half-life of metolachlor (15.5 d) in the field as compared to alachlor (8 d). Runoff data also showed higher concentrations of alachlor ESA as compared to metolachlor ESA, even though they were applied at the same levels. Data from soil cores showed transport of the ESA compounds in soil to as far down as 75-90 cm below the surface, at concentrations ranging from less than 0.5 ??g/L to about 50 ??g/L. In contrast, no parent herbicide was detected at these depths. This observation correlates with the higher log KOC values for alachlor (3.33) and metolachlor (3.01) relative to their corresponding ESA metabolites, alachlor ESA (2.26), and metolachlor ESA (2.29).

Atmospheric Climate Experiment Plus

NASA Astrophysics Data System (ADS)

Lundahl, K.

ACE+ is an atmospheric sounding mission using radio occultation techniques and is a combination of the two Earth Explorer missions ACE and WATS earlier proposed to ESA. ACE was highly rated by ESA in the Call for Earth Explorer Opportunity Missions in 1999 and was prioritised as number three and selected as a "hot-stand-by". A phase A study was carried out during 2000 and 2001. ACE will observe atmospheric parameters using radio occultations from an array of 6 micro-satellites which track the L- band signal of GPS satellites to map the detailed refractivity and thermal structure of the global atmosphere from surface to space. Water vapour and wind in Atmospheric Troposphere and Stratosphere WATS was the response to ESA's Call for Ideas for the next Earth Explorer Core Missions in 2001. WATS combines ACE GPS atmospheric occultations and LEO-LEO cross-link occultations. Cross-links strongly enhance the capability of measuring humidity relative to the ACE mission. The Earth Science Advisory Committée at ESA noted that the LEO-GNSS occultation technique is already well established through several missions in recent years and could not recommend WATS for a Phase A study as an Earth Explorer Core Mission. The ESAC was, however, deeply impressed by the LEO-LEO component of the WATS proposal and would regard it as regrettable if this science would be lost and encourages the ACE/WATS team to explore other means to achieve its scientific goal. ACE+ is therefore the response to ESA's 2nd Call for Earth Explorer Opportunity Missions in 2001 and will contribute in a significant manner to ESA's Living Planet Programme. ACE+ will considerably advance our knowledge about atmosphere physics and climate change processes. The mission will demonstrate a highly innovative approach using radio occultations for globally measuring profiles of humidity and temperature throughout the atmosphere and stratosphere. A constellation of 4 small satellites, tracking L-band GPS/GALILEO signals and X/K-band LEO-LEO cross-link signals, will be launched in 2 counter-rotating orbits with 2 satellites in each at 650 and 850 km respectively. Several aspects drive the spacecraft design. The GRAS+ and CALL+ instruments have a relatively high power consumption. The pointing and stability requirements call for a fully capable 3-axis attitude control system. Satellite characteristics include a mass of 130 kg, and available power of 80 W. The bus is based on the SMART-1 satellite from Swedish Space Corporation. In order to meet the cost envelope of the Earth Explorer Opportunity Missions the spacecraft should be a simple and robust design and makes use of the latest, but proven, technical developments as CAN-bus, GaAs solar cells and Li-Ion batteries. Low cost launch with a mix of START-1 and Rockot is also foreseen and could take place in 2006-2007. This paper describes mission characteristics and technical solutions for ACE+ .

Restricted Use of Erythropoiesis-Stimulating Agent is Safe and Associated with Deferred Dialysis Initiation in Stage 5 Chronic Kidney Disease

PubMed Central

Pan, Szu-Yu; Chiang, Wen-Chih; Chen, Ping-Min; Liu, Heng-Hsiu; Chou, Yu-Hsiang; Lai, Tai-Shuan; Lai, Chun-Fu; Chiu, Yen-Ling; Lin, Wan-Yu; Chen, Yung-Ming; Chu, Tzong-Shinn; Lin, Shuei-Liong

2017-01-01

The effect of erythropoiesis-stimulating agent (ESA) on dialysis initiation in advanced chronic kidney disease (CKD) patients is not clear. We retrospectively analyzed the outcome of dialysis initiation in a stage 5 CKD cohort with ESA reimbursement limited to the maximal standardized monthly ESA dose equivalent to epoetin beta 20,000 U by the National Health Insurance program. Totally 423 patients were followed up for a median of 1.37 year. A time-dependent Cox regression model, adjusted for monthly levels of estimated glomerular filtration rate (eGFR) and hemoglobin, was constructed to investigate the association between ESA and outcome. The standardized monthly ESA dose in ESA users was 16,000 ± 3,900 U of epoetin beta. Annual changes of hemoglobin were −0.29 ± 2.19 and −0.99 ± 2.46 g/dL in ESA users and ESA non-users, respectively (P = 0.038). However, annual eGFR decline rates were not different between ESA users and non-users. After adjustment, ESA use was associated with deferred dialysis initiation (hazard ratio 0.63, 95% confidence interval 0.42–0.93, P = 0.021). The protective effect remained when the monthly ESA doses were incorporated. Our data showed that restricted use of ESA was safe and associated with deferred dialysis initiation in stage 5 CKD patients. PMID:28272424

Design concepts and options for the Thermal Infrared Imager (TIRI) as part of ESA's Asteroid Impact Mission.

NASA Astrophysics Data System (ADS)

Bowles, Neil; Calcutt, Simon; Licandro, Javier; Reyes, Marcos; Delbo, Marco; Donaldson Hanna, Kerri; Arnold, Jessica; Howe, Chris

2016-04-01

ESA's Asteroid Impact Mission (AIM) is being studied as part of the joint ESA/NASA AIDA mission for launch in 2020. AIDA's primary mission is to investigate the effect of a kinetic impactor on the secondary component of the binary asteroid 65803 Didymos in late 2022. AIM will characterise the Didymos system and monitor the response of the binary system to the impact. A multi-spectral, thermal-infrared imaging instrument (TIRI) will be an essential component of AIM's remote sensing payload, as it will provide key information on the nature of the surfaces (e.g. presence or absence of materials, degree of compaction, and rock abundance of the regolith) of both components in the Didymos system. The temperature maps provided by TIRI will be important for navigation and spacecraft health and safety for proximity/lander operations. By measuring the asteroids' diurnal thermal responses (thermal inertia) and their surface compositions via spectral signatures, TIRI will provide information on the origin and evolution of the binary system. In this presentation we will discuss possible instrument design for TIRI, exploring options that include imaging spectroscopy to broadband imaging. By using thermal models and compositional analogues of the Didymos system we will show how the performance of each design option compares to the wider scientific goals of the AIDA/AIM mission.

Valuing improvements to threatened and endangered marine species: an application of stated preference choice experiments.

PubMed

Wallmo, Kristy; Lew, Daniel K

2011-07-01

Non-market valuation research has produced value estimates for over forty threatened and endangered (T&E) species, including mammals, fish, birds, and crustaceans. Increasingly, Stated Preference Choice Experiments (SPCE) are utilized for valuation, as the format offers flexibility for policy analysis and may reduce certain types of response biases relative to the more traditional Contingent Valuation method. Additionally, SPCE formats can allow respondents to make trade-offs among multiple species, providing information on the distinctiveness of preferences for different T&E species. In this paper we present results of an SPCE involving three U.S. Endangered Species Act (ESA)-listed species: the Puget Sound Chinook salmon, the Hawaiian monk seal, and the smalltooth sawfish. We estimate willingness-to-pay (WTP) values for improving each species' ESA listing status and statistically compare these values between the three species using a method of convolutions approach. Our results suggest that respondents have distinct preferences for the three species, and that WTP estimates differ depending on the species and the level of improvement to their ESA status. Our results should be of interest to researchers and policy-makers, as we provide value estimates for three species that have limited, if any, estimates available in the economics literature, as well as new information about the way respondents make trade-offs among three taxonomically different species. Copyright © 2011 Elsevier Ltd. All rights reserved.

Evaluation of a Petition Requesting National Marine Fisheries Service (NMFS) to List the Smooth Hammerhead Shark (Sphryna zygaena) as a Threatened or Endangered Species Under the Endangered Species Act (ESA)

NASA Astrophysics Data System (ADS)

Sturm, A. B.

2016-12-01

The wildlife conservation organization, Defenders of Wildlife, petitioned NMFS to list the smooth hammerhead shark, Sphryna zygaena, as endangered or threatened throughout its range under the ESA. The petition was critically evaluated to determine if the petitioners presented substantial scientific or commercial information indicating that the smooth hammerhead shark may warrant listing under the ESA. The petition and the cited scientific literature (as well as scientific literature readily available in NMFS files) were evaluated to determine if the smooth hammerhead shark may be threatened or endangered because of any one or a combination of the following five ESA section 4(a)(1) factors: (1) present or threatened destruction, modification, or curtailment of its habitat or range; (2) over utilization for commercial, recreational, scientific, or educational purposes; (3) disease or predation; (4) inadequacy of existing regulatory mechanisms; (5) or other natural or manmade factors affecting its continued existence. The available scientific literature indicates that the smooth hammerhead shark populations have declined in multiple regions. Smooth hammerhead sharks may warrant listing due to ongoing threats of over utilization for commercial purposes by global fisheries that target and retain incidental catch of these species to obtain their high-value fins, possible inadequacies in global regulatory mechanisms to control this level of exploitation, and natural factors (such as inherent biological vulnerabilities) that may be exacerbating these threats. Based on these findings, the smooth hammerhead shark may warrant listing as a threatened or endangered species under the ESA and a status review of the species is currently being conducted.

Evaluation of a Petition Requesting National Marine Fisheries Service (NMFS) to List the Smooth Hammerhead Shark (Sphryna zygaena) as a Threatened or Endangered Species Under the Endangered Species Act (ESA)

NASA Astrophysics Data System (ADS)

Sturm, A. B.

2016-02-01

The wildlife conservation organization, Defenders of Wildlife, petitioned NMFS to list the smooth hammerhead shark, Sphryna zygaena, as endangered or threatened throughout its range under the ESA. The petition was critically evaluated to determine if the petitioners presented substantial scientific or commercial information indicating that the smooth hammerhead shark may warrant listing under the ESA. The petition and the cited scientific literature (as well as scientific literature readily available in NMFS files) were evaluated to determine if the smooth hammerhead shark may be threatened or endangered because of any one or a combination of the following five ESA section 4(a)(1) factors: (1) present or threatened destruction, modification, or curtailment of its habitat or range; (2) over utilization for commercial, recreational, scientific, or educational purposes; (3) disease or predation; (4) inadequacy of existing regulatory mechanisms; (5) or other natural or manmade factors affecting its continued existence. The available scientific literature indicates that the smooth hammerhead shark populations have declined in multiple regions. Smooth hammerhead sharks may warrant listing due to ongoing threats of over utilization for commercial purposes by global fisheries that target and retain incidental catch of these species to obtain their high-value fins, possible inadequacies in global regulatory mechanisms to control this level of exploitation, and natural factors (such as inherent biological vulnerabilities) that may be exacerbating these threats. Based on these findings, the smooth hammerhead shark may warrant listing as a threatened or endangered species under the ESA and a status review of the species is currently being conducted.

ESA GlobPermafrost - mapping the extent and thermal state of permafrost with satellite data

NASA Astrophysics Data System (ADS)

Westermann, Sebastian; Obu, Jaroslav; Aalstad, Kristoffer; Bartsch, Annett; Kääb, Andreas

2017-04-01

The ESA GlobPermafrost initiative (2016-2019) aims at developing, validating and implementing information products based on remote sensing data to support permafrost research. Mapping of permafrost extent and ground temperatures is conducted at 1 km scale using remotely sensed land surface temperatures (MODIS), snow water equivalent (ESA GlobSnow) and land cover (ESA CCI landcover) in conjunction with a simple ground thermal model (CryoGrid 1). The spatial variability of the ground thermal regime at scales smaller than the model resolution is explicitly taken into account by considering an ensemble of realizations with different model properties. The approach has been tested for the unglacierized land areas in the North Atlantic region, an area of more than 5 million km2. The results have been compared to in-situ temperature measurements in more than 100 boreholes, indicating an accuracy of approximately 2.5°C. Within GlobPermafrost, the scheme will be extended to cover the entire the circum-polar permafrost area. Here, we provide an evaluation of the first prototype covering "lowland" permafrost areas north of 40° latitude (available on www.globpermafrost.info in early 2017). We give a feasibility assessment for extending the scheme to global scale, including both mountain and Antarctic permafrost. Finally, we discuss the potential and limitations for estimating changes of permafrost extent on decadal timescales.

ISO finds a very steamy cloud in interstellar space

NASA Astrophysics Data System (ADS)

1998-04-01

The discovery, which may provide an important clue to the origin of water in the Solar System, is reported in an article in Astrophysical Journal Letters, to be published on 20 April. This Information Note is distributed simultaneously with a Press Release on the same subject from Cornell University, Johns Hopkins University, the Harvard/Smithsonian Center for Astrophysics, and NASA's Ames Research Center. The water vapour is in the Orion Molecular Cloud, a giant interstellar mass composed primarily of hydrogen molecules. The observations were carried out in October 1997 with the Long Wavelength Spectrometer, devised by a British-led team as one of four instruments on board ISO. Looking at long infrared wavelengths, the astronomers saw the characteristic signature of emission by water vapour. "The interstellar gas cloud that we observed is being pummelled by shock waves that compress and heat the gas," says Martin Harwit of Cornell University, an ISO mission scientist and lead author on the article reporting the finding. "These shock waves are the result of the violent early stages of starbirth, in which a young star spews out gas that slams into its surroundings at high speed. The heated water vapour that we observed is the result of that collision." Harwit also suggests that shock waves are a cause of starbirth as well as a result. "In the future," he says, "they may also trigger the formation of additional stars and planets as they compress the gas cloud that we observed, but only if surplus heat can be radiated away. Even though the interstellar gas is composed primarily of hydrogen molecules, water vapour is a particularly efficient radiator at far-infrared wavelengths and plays a critical role in cooling the gas and facilitating the star formation process. Because the Earth's own wet atmosphere is completely opaque at the wavelengths of interest, the observations that we are reporting today are possible only from space with the use of the ISO satellite." A correct prediction The concentration of water vapour measured by the US team was roughly one part in 2000 by volume, far larger than any measured previously in interstellar space. But the strength of the water radiation detected from Orion was in perfect agreement with theoretical predictions in the PhD thesis of team member Michael Kaufman, a former Johns Hopkins graduate student now at NASA's Ames Research Center. "An enhanced concentration of water is precisely what we expected in this gas cloud," comments team member Gary Melnick of the Harvard-Smithsonian Center for Astrophysics. "We are looking at a region of interstellar space where shock waves have made the gas abnormally warm. For the past 25 years, astrophysicists have been predicting that whenever the temperature exceeds about 100 °C, chemical reactions will convert most of the oxygen atoms in the interstellar gas into water. And that's exactly what we've observed in Orion." The source of the water we live by The high concentration of water measured in Orion may have also had implications for the origin of water in the Solar System and on the Earth itself, according to team member David Neufeld of Johns Hopkins University. "The interstellar gas cloud that we observed in Orion seems to be a huge chemical factory," Neufeld says, "generating enough water molecules in a single day to fill the Earth's oceans sixty times over. Eventually that water vapour will cool and freeze, turning into small solid particles of ice. Similar ice particles were presumably present within the gas cloud from which the Solar System originally formed. It seems quite plausible that much of the water in the Solar System was originally produced in a giant water-vapour factory like the one we have observed in Orion." A footnote about ISO ISO was put into orbit in November 1995, by an Ariane 44PP launcher at the European space base at Kourou in French Guiana. As an unprecedented observatory for infrared astronomy, able to examine cool and hidden places in the Universe, ISO has observed more than 26,000 individual objects. A supply of liquid helium, used to cool the telescope and instruments close to the absolute zero of temperature, has lasted much longer than expected, but ran out on 8 April 1998 (see ESA Press Information Note N°11-98 of 9 April). Further information is available from: ESA Public Relations Division Tel: +33(0)1.53.69.71.55 Fax : +33(0)1.53.69.76.90 ESA ISO: Dr Martin Kessler at +34.(9)1.813.12.53 or mkessler@iso.vilspa.esa.es And from US team members: Prof. Martin Harwit at +1 202-479-6877 or mharwit@ibm.net Prof. David Neufeld at +1 410-516-8582 or neufeld@pha.jhu.edu Dr Gary Melnick at +1 617-495-7388 or gmelnick@cfa.harvard.edu Dr Michael Kaufman at +1 650-604-0320 or kaufman@warped.arc.nasa.gov ISO on the Internet For more details about ISO, and a picture gallery, visit the website: http://isowww.estec.esa.nl Panels showing two examples of measurements carried out on board the ISO, together with an image of the Orion nebula taken with the Wide Field Planetary Camera 2 on NASA's Hubble Space Telescope can be seen on the World Wide Web at http://www.pha.jhu.edu/~neufeld/orionwater.html.

SPICE for ESA Planetary Missions

NASA Astrophysics Data System (ADS)

Costa, M.

2018-04-01

The ESA SPICE Service leads the SPICE operations for ESA missions and is responsible for the generation of the SPICE Kernel Dataset for ESA missions. This contribution will describe the status of these datasets and outline the future developments.

GeoMEx: Geographic Information System (GIS) Prototype for Mars Express Data

NASA Astrophysics Data System (ADS)

Manaud, N.; Frigeri, A.; Ivanov, A. B.

2013-09-01

As of today almost a decade of observational data have been returned by the multidisciplinary instruments on-board the ESA's Mars Express spacecraft. All data are archived into the ESA's Planetary Science Archive (PSA), which is the central repository for all ESA's Solar System missions [1]. Data users can perform advanced queries and retrieve data from the PSA using graphical and map-based search interfaces, or via direct FTP download [2]. However the PSA still offers limited geometrical search and visualisation capabilities that are essential for scientists to identify their data of interest. A former study has shown [3] that this limitation is mostly due to the fact that (1) only a subset of the instruments observations geometry information has been modeled and ingested into the PSA, and (2) that the access to that information from GIS software is impossible without going through a cumbersome and undocumented process. With the increasing number of Mars GIS data sets available to the community [4], GIS software have become invaluable tools for researchers to capture, manage, visualise, and analyse data from various sources. Although Mars Express surface imaging data are natural candidates for use in a GIS environment, other non-imaging instruments data (subsurface, atmosphere, plasma) integration is being investigated [5]. The objective of this work is to develop a GIS prototype that will integrate all the Mars Express instruments observations geometry information into a spatial database that can be accessed from external GIS software using standard WMS and WFS protocols. We will firstly focus on the integration of surface and subsurface instruments data (HRSC, OMEGA, MARSIS). In addition to the geometry information, base and context maps of Mars derived from surface mapping instruments data will also be ingested into the system. The system back-end architecture will be implemented using open-source GIS frameworks: PostgreSQL/PostGIS for the database, and MapServer for the web publishing module. Interfaces with existing GIS front-end software (such as QGIS, GRASS, ArcView, or OpenLayers) will be investigated and tested in a second phase. This prototype is primarily intended to be used by the Mars Express instruments teams in support to their scientific investigations. It will also be used by the mission Archive Scientist in support to the data validation and PSA interface requirements definition tasks. Depending on its success, this prototype might be used in the future to demonstrate the benefit of a GIS component integration to ESA's planetary science operations planning systems.

MSG RAO Presentation

NASA Astrophysics Data System (ADS)

Oriol-Pibernat, E.; Govaerts, Y.

2004-11-01

BACKGROUND The Meteosat Second Generation (MSG) Research Announcement of Opportunity (RAO) was released by ESA and EUMETSAT in 1999, after a first warning issued in September 1998. The RAO main objective is to promote the scientific use of the new MSG satellites outside the operational meteorological user community, also in synergy with ERS and Envisat data. The variety and quality of the selected proposals proved the usefulness of such joint initiative. 2. STATUS OF THE RAO A total of 43 proposals were selected in 1999. Following the delay in the MSG-1 launch (which operational name is Meteosat-8), the PIs were contacted in early 2003 in order to confirm the interest to continue with the project. There were 5 withdrawals due to various reasons. The PIs have been receiving news through a dedicated WEB site or by emails. Each PI has been assigned a correspondent from ESA or EUMETSAT to follow up the project through the site: http://eopi.esa.int/esa/esa where the papers presented at this Workshop will be included as the first report. 3. THE MSG RAO WORKSHOPS In the framework of the MSG RAO, a series of workshops are organised which goal is to establish a structured dialogue and interactions among the MSG Principal Investigators (PIs) and ESA/EUMETSAT, respectively. Each of these workshops is focusing on a specific aspect, in addition to the necessary exchange of information. 4. OBJECTIVES OF THE BOLOGNA WORKSHOP The focus of the first workshop (17-19 May 2000) was on the presentation of MSG features and of all selected RAO projects. It was a starting point for continued interaction within the MSG RAO community (selected PIs and their co-Investigators, Co-Is). The first MSG RAO workshop provided a forum for discussion among scientists, and ESA and EUMETSAT, leading to a continuous scientific co-operation. Requirements and possibilities with regard to data delivery were formulated and discussed at this workshop. In particular, PIs were asked to specify the minimal and nominal data requirements for the first year after the end of the MSG commissioning. PI's recommendations formulated at this first workshop resulted in an increase of delivery capability of SEVIRI data from the archive and the development of a simple IDL interface to handle SEVIRI data.

The utility of the Edmonton Symptom Assessment System in screening for anxiety and depression.

PubMed

Bagha, S M; Macedo, A; Jacks, L M; Lo, C; Zimmermann, C; Rodin, G; Li, M

2013-01-01

The Edmonton Symptom Assessment System (ESAS) is a common screening tool in cancer, although its validity for distress screening is unproven. Here, screening performance of the ESAS anxiety (ESAS-A) and depression (ESAS-D) items were validated against the anxiety [Generalised Anxiety Disorder-7 (GAD-7)] and depression [Patient Health Questionnaire-9 (PHQ-9)] subscales of the PHQ. A total of 1215 cancer patients completed the Distress Assessment and Response Tool (DART), a computerised distress screening instrument. Spearman's rank correlation coefficients and receiver operating characteristic curve analyses were used to evaluate the ability of ESAS-A and ESAS-D to identify moderate distress (GAD-7/PHQ-9 ≥ 10). Spearman's rank correlation coefficients comparing ESAS-A and ESAS-D with GAD-7 and PHQ-9 were 0.74 and 0.72 respectively. Areas under the receiver operating characteristic curves were 0.89 and 0.88 for anxiety and depression respectively. A cut-off of ≥3 on ESAS-A demonstrated a sensitivity of 0.91, specificity of 0.68, positive predictive value of 0.34 and negative predictive value of 0.97. A cut-off of ≥2 on the ESAS-D demonstrated a sensitivity of 0.86, specificity of 0.72, positive predictive value of 0.46 and negative predictive value of 0.95. High sensitivities of ESAS-A and ESAS-D at certain cut-offs suggest they have use in ruling-out distress. However, their low specificities indicate secondary screening is needed to rule-in anxiety or depression for case-finding. © 2012 Blackwell Publishing Ltd.

Reiter conducts EVA tool config in Node 1 / Unity module

NASA Image and Video Library

2006-11-16

ISS014-E-08055 (16 Nov. 2006) --- European Space Agency (ESA) astronaut Thomas Reiter, Expedition 14 flight engineer, takes inventory of hardware during an Information Management System (IMS) update in the Unity node of the International Space Station.

First 3D view of solar eruptions

NASA Astrophysics Data System (ADS)

2004-07-01

CME as seen by LASCO Figure 1. A classical three-part CME inside the LASCO C3 field of view, showing a bright frontal loop (shaped like a lightbulb)surrounding a dark cavity with a bright core. This CME is headed roughly 90 degrees away from Earth. The uniform disk in the centre of the image is where the occulter is placed, blocking out all direct sunlight. The approximate size of the Sun is indicated by the white circle in the middle. Click here CME as seen by LASCO Figure 2. A similar CME heading almost directly towards Earth, observed by LASCO C2 which has a smaller field of view than C3. The size of the Sun is indicated by the larger circle, and the x-marked circle on the Sun shows the origin of the CME. Panel a shows the total intensity (darker means more intensity) as imaged directly by LASCO. Only the narrow lower end of the 'lightbulb' shape is visible - the widest portion has expanded beyond the field of view, whereas the front part and the core are too dim to be seen or hidden behind the occulter. Panel d is a topographic map of the material shown in panel a. The distance from the plane of the Sun to the material is colour coded - the scale in units of solar radii is shown on the side. Panels b and c show the intensity as it would have appeared to an observer positioned to the side of the Sun or directly above it, respectively. Click here CMEs are the most powerful eruptions in the Solar System, with thousands of millions of tonnes of electrified gas being blasted from the Sun's atmosphere into space at millions of kilometres per hour. Researchers believe that CMEs are launched when solar magnetic fields become strained and suddenly 'snap' to a new configuration, like a rubber band that has been twisted to the breaking point. To fully understand the origin of these powerful blasts and the process that launches them from the Sun, scientists need to see the structure of CMEs in three dimensions. "Views in three dimensions will help us to better predict CME arrival times and impact angles at the Earth," says Dr Thomas Moran of the Catholic University, Washington, USA. In collaboration with Dr Joseph Davila, of NASA’s Goddard Space Flight Center, Greenbelt, USA, Moran has analysed two-dimensional images from the ESA/NASA Solar and Heliospheric Observatory (SOHO) in a new way to yield 3D images. Their technique is able to reveal the complex and distorted magnetic fields that travel with the CME cloud and sometimes interact with Earth's own magnetic field, pouring tremendous amounts of energy into the space near Earth. "These magnetic fields are invisible," Moran explains, "but since the CME gas is electrified, it spirals around the magnetic fields, tracing out their shapes." Therefore, a 3D view of the CME electrified gas (called a plasma) gives scientists valuable information on the structure and behaviour of the magnetic fields powering the CME. The new analysis technique for SOHO data determines the three-dimensional structure of a CME by taking a sequence of three SOHO Large Angle and Spectrometric Coronagraph (LASCO) images through various polarisers, at different angles. Whilst the light emitted by the Sun is not polarised, once it is scattered off electrons in the CME plasma it takes up some polarisation. This means that the electric fields of some of the scattered light are forced to oscillate in certain directions, whereas the electric field in the light emitted by the Sun is free to oscillate in all directions. Moran and Davila knew that light from CME structures closer to the plane of the Sun (as seen on the LASCO images) had to be more polarised than light from structures farther from that plane. Thus, by computing the ratio of polarised to unpolarised light for each CME structure, they could measure its distance from the plane. This provided the missing third dimension to the LASCO images. With this technique, the team has confirmed that the structure of CMEs directed towards Earth is an expanding arcade of loops, rather than a bubble or rope-like structure. Although this technique had been independently developed previously to study relatively static structures in the solar atmosphere during eclipses, this is the first time that it is applied to fast moving CMEs. Moran and Davila believe that their method will complement data from the upcoming NASA’s Solar Terrestrial Relations Observatory (STEREO) mission, scheduled for launch in February 2006. STEREO will use two widely separated spacecraft to construct 3D views of CMEs by combining images from the different vantage points of the twin spacecraft. Commenting on this result, Bernhard Fleck, SOHO Project Scientist at ESA, said: "These are really amazing images. Once again scientists have come up with a clever idea for analysing SOHO data in ways that were not even dreamt of when the mission was designed." Movie: http://esamultimedia.esa.int/images/spcs/soho/soho20040702.mpg 3 stills from the movie http://esamultimedia.esa.int/images/spcs/soho/soho20040702c.tiff http://esamultimedia.esa.int/images/spcs/soho/soho20040702d.tiff http://esamultimedia.esa.int/images/spcs/soho/soho20040702e.tiff This movie shows a 3D rendering of the data in Figure 2. It starts out viewing the Sun from SOHO's perspective, then rotates the scene to view the data from the side, and finally from the top. Note that one distinct feature shown at about 11 o'clock in Figure 2 panel a has been left out of the movie, because it is a static structure and not a part of the CME. Notes to Editors: This new result by T. Moran and J. Davila is published in today’s issue of the magazine Science. More about SOHO SOHO is a project of international co-operation between ESA and NASA to study the Sun, from its deep core to the outer corona, and the solar wind. Fourteen European countries, led by the European Space Agency and prime contractor Astrium (formerly Matra-Marconi), built the SOHO spacecraft. It carries twelve instruments (nine European-led and three American-led) and was launched by an NASA's Atlas II-AS rocket on 2 December 1995. Mission operations are co-ordinated at NASA's Goddard Space Flight Centre. The spacecraft was designed for a two-year mission but its spectacular success has led to two extensions of the mission, the first until 2003, and then again until March 2007. For more information about SOHO visit: http://soho.estec.esa.nl

The impact of note taking style and note availability at retrieval on mock jurors' recall and recognition of trial information.

PubMed

Thorley, Craig; Baxter, Rebecca E; Lorek, Joanna

2016-01-01

Jurors forget critical trial information and what they do recall can be inaccurate. Jurors' recall of trial information can be enhanced by permitting them to take notes during a trial onto blank sheets of paper (henceforth called freestyle note taking). A recent innovation is the trial-ordered-notebook (TON) for jurors, which is a notebook containing headings outlining the trial proceedings and which has space beneath each heading for notes. In a direct comparison, TON note takers recalled more trial information than freestyle note takers. This study investigated whether or not note taking improves recall as a result of enhanced encoding or as a result of note access at retrieval. To assess this, mock jurors watched and freely recalled a trial video with one-fifth taking no notes, two-fifths taking freestyle notes and two-fifths using TONs. During retrieval, half of the freestyle and TON note takers could access their notes. Note taking enhanced recall, with the freestyle note takers and TON note takers without note access performing equally as well. Note taking therefore enhances encoding. Recall was greatest for the TON note takers with note access, suggesting a retrieval enhancement unique to this condition. The theoretical and applied implications of these findings are discussed.

A framework for air quality monitoring based on free public data and open source tools

NASA Astrophysics Data System (ADS)

Nikolov, Hristo; Borisova, Denitsa

2014-10-01

In the recent years more and more widely accepted by the Space agencies (e.g. NASA, ESA) is the policy toward provision of Earth observation (EO) data and end products concerning air quality especially in large urban areas without cost to researchers and SMEs. Those EO data are complemented by increasing amount of in-situ data also provided at no cost either from national authorities or having crowdsourced origin. This accessibility together with the increased processing capabilities of the free and open source software is a prerequisite for creation of solid framework for air modeling in support of decision making at medium and large scale. Essential part of this framework is web-based GIS mapping tool responsible for dissemination of the output generated. In this research an attempt is made to establish a running framework based solely on openly accessible data on air quality and on set of freely available software tools for processing and modeling taking into account the present status quo in Bulgaria. Among the primary sources of data, especially for bigger urban areas, for different types of gases and dust particles, noted should be the National Institute of Meteorology and Hydrology of Bulgaria (NIMH) and National System for Environmental Monitoring managed by Bulgarian Executive Environmental Agency (ExEA). Both authorities provide data for concentration of several gases just to mention CO, CO2, NO2, SO2, and fine suspended dust (PM10, PM2.5) on monthly (for some data on daily) basis. In the framework proposed these data will complement the data from satellite-based sensors such as OMI instrument aboard EOS-Aura satellite and from TROPOMI instrument payload for future ESA Sentinel-5P mission. Integral part of the framework is the modern map for the land use/land cover which is provided from EEA by initiative GIO Land CORINE. This map is also a product from EO data distributed at European level. First and above all, our effort is focused on provision to the wider public living in urbanized areas with one reliable source of information on the present conditions concerning the air quality. Also this information might be used as indicator for presence of acid rains in agriculture areas close to industrial or electricity plants. Its availability at regular basis makes such information valuable source in case of manmade industrial disasters or incidents such as forest fires. Key issue in developing this framework is to ensure the delivery of reliable data products related to air quality at larger scale that those available at the moment.

XMM-Newton detects X-ray 'solar cycle' in distant star

NASA Astrophysics Data System (ADS)

2004-05-01

The Sun as observed by SOHO hi-res Size hi-res: 708 Kb The Sun as observed by SOHO The Sun as observed by the ESA/NASA SOHO observatory near the minimum of the solar cycle (left) and near its maximum (right). The signs of solar activity near the maximum are clearly seen. New XMM-Newton observations suggest that this behaviour may be typical of stars like the Sun, such as HD 81809 in the constellation Hydra. Solar flare - 4 November 2003 The huge flare produced on 4 November 2003 This image of the Sun, obtained by the ESA/NASA SOHO observatory, shows the powerful X-ray flare that took place on 4 November 2003. The associated coronal mass ejection, coming out of the Sun at a speed of 8.2 million kilometres per hour, hit the Earth several hours later and caused disruptions to telecommunication and power distribution lines. New XMM-Newton observations suggest that this behaviour may be typical of stars like the Sun, such as HD 81809 in the constellation Hydra. Since the time Galileo discovered sunspots, in 1610, astronomers have measured their number, size and location on the disc of the Sun. Sunspots are relatively cooler areas on the Sun that are observed as dark patches. Their number rises and falls with the level of activity of the Sun in a cycle of about 11 years. When the Sun is very active, large-scale phenomena take place, such as the flares and coronal mass ejections observed by the ESA/NASA solar observatory SOHO. These events release a large amount of energy and charged particles that hit the Earth and can cause powerful magnetic storms, affecting radio communications, power distribution lines and even our weather and climate. During the solar cycle, the X-ray emission from the Sun varies by a large amount (about a factor of 100) and is strongest when the cycle is at its peak and the surface of the Sun is covered by the largest number of spots. ESA's X-ray observatory, XMM-Newton, has now shown for the first time that this cyclic X-ray behaviour is common to other stars as well. A team of astronomers, led by Fabio Favata, from ESA's European Space Research and Technology Centre, The Netherlands, has monitored a small number of solar-type stars since the beginning of the XMM-Newton mission in 2000. The X-ray brightness of HD 81809, a star located 90 light years away in the constellation Hydra (the water snake), has varied by more than 10 times over the past two and a half years, reaching a well defined peak in mid 2002. The star has shown the characteristic X-ray modulation (brightening and dimming) typical of the solar cycle. "This is the first clear sign of a cyclic pattern in the X-ray emission of stars other than the Sun," said Favata. Furthermore, the data show that these variations are synchronised with the starspot cycle. If HD 81809 behaves like the Sun, its X-ray brightness can vary by a factor of one hundred over a few years. "We might well have caught HD 81809 at the beginning of an X-ray activity cycle," added Favata. The existence of starspot cycles on other stars had already been established long ago, thanks to observations that began in the 1950s. However, scientists did not know whether the X-ray radiation would also vary with the number of starspots. ESA's XMM-Newton has now shown that this is indeed the case and that this cyclic X-ray pattern is not typical of the Sun alone. "This suggests that our Sun's behaviour is probably nothing exceptional," said Favata. Besides its interest for scientists, the Sun's cyclical behaviour can have an influence on everyone on Earth. Our climate is known to be significantly affected by the high-energy radiation emitted by the Sun. For instance, a temporary disappearance of the solar cycle in the 18th century corresponded with an exceptionally cold period on Earth. Similarly, in the early phases of the lifetime of a planet, this high-energy radiation has a strong influence on the conditions of the atmosphere, and thus potentially on the development of life. Finding out whether the Sun's X-ray cycle is common among other solar-type stars, and in particular among those hosting potential rocky planets, can give scientists much needed clues on whether and where other forms of life might exist outside the Solar System. At the same time, understanding how typical and long-lasting is the solar behaviour will tell us more about the evolution of the climate on Earth. Further observations of HD 81809 and other similar stars are already planned with XMM-Newton. They will allow astronomers to study whether the large modulations in X-ray brightness observed in the Sun are indeed the norm for stars of its type. Understanding how other solar-like stars behave in general will give scientists better insight into the past and future of our own Sun. Note to editors The results described here were published in the April issue of the scientific journal Astronomy and Astrophysics (Vol. 418, p. L13). The authors of the paper are F. Favata, G. Micela, S. Baliunas, J. Schmitt, M. Guedel, F. Harnden Jr., S. Sciortino and R. Stern. A reprint of the paper can be found at: http://arxiv.org/abs/astro-ph/0403142 More about XMM-Newton XMM-Newton can detect more X-ray sources than any previous satellite and is helping to solve many cosmic mysteries of the violent Universe, from black holes to the formation of galaxies. It was launched on 10 December 1999, using an Ariane-5 rocket from French Guiana. It is expected to return data for a decade. XMM-Newton's high-tech design uses over 170 wafer-thin cylindrical mirrors spread over three telescopes. Its orbit takes it almost a third of the way to the Moon, so that astronomers can enjoy long, uninterrupted views of celestial objects. More information on XMM-Newton can be found at: http://www.esa.int/esaSC/SEMM8IGHZTD_1_spk.html More about SOHO SOHO is a project of international cooperation between ESA and NASA to study the Sun, from its deep core to the outer corona, and the solar wind. Fourteen European countries, led by the European Space Agency and prime contractor Astrium (formerly Matra-Marconi), built the SOHO spacecraft. It carries twelve instruments (nine European-led and three American-led) and was launched by an NASA's Atlas II-AS rocket on 2 December 1995. Mission operations are coordinated at NASA's Goddard Space Flight Centre. The spacecraft was designed for a two-year mission but its spectacular success has led to two extensions of the mission, the first until 2003, and then again until March 2007. More information on SOHO can be found at: http://www.esa.int/esaSC/SEMJFH374OD_1_spk.html

ESA SSA Space Weather Services Supporting Space Surveillance and Tracking

NASA Astrophysics Data System (ADS)

Luntama, Juha-Pekka; Glover, Alexi; Hilgers, Alain; Fletcher, Emmet

2012-07-01

ESA Space Situational Awareness (SSA) Preparatory Programme was started in 2009. The objective of the programme is to support the European independent utilisation of and access to space research or services. This will be performed through providing timely and quality data, information, services and knowledge regarding the environment, the threats and the sustainable exploitation of the outer space surrounding the planet Earth. SSA serves the implementation of the strategic missions of the European Space Policy based on the peaceful uses of the outer space by all states, by supporting the autonomous capacity to securely and safely operate the critical European space infrastructures. The Space Weather (SWE) Segment of the SSA will provide user services related to the monitoring of the Sun, the solar wind, the radiation belts, the magnetosphere and the ionosphere. These services will include near real time information and forecasts about the characteristics of the space environment and predictions of space weather impacts on sensitive spaceborne and ground based infrastructure. The SSA SWE system will also include establishment of a permanent database for analysis, model development and scientific research. These services are will support a wide variety of user domains including spacecraft designers, spacecraft operators, human space flights, users and operators of transionospheric radio links, and space weather research community. The precursor SWE services to be established starting in 2010. This presentation provides an overview of the ESA SSA SWE services focused on supporting the Space Surveillance and Tracking users. This services include estimates of the atmospheric drag and archive and forecasts of the geomagnetic and solar indices. In addition, the SSA SWE system will provide nowcasts of the ionospheric group delay to support mitigation of the ionospheric impact on radar signals. The paper will discuss the user requirements for the services, the data requirements and the foreseen development needs for the ESA SSA SWE system before the full service capability is available.

Infrastructure for Planetary Sciences: Universal planetary database development project

NASA Astrophysics Data System (ADS)

Kasaba, Yasumasa; Capria, M. T.; Crichton, D.; Zender, J.; Beebe, R.

The International Planetary Data Alliance (IPDA), formally formed under COSPAR (Formal start: from the COSPAR 2008 at Montreal), is a joint international effort to enable global access and exchange of high quality planetary science data, and to establish archive stan-dards that make it easier to share the data across international boundaries. In 2008-2009, thanks to the many players from several agencies and institutions, we got fruitful results in 6 projects: (1) Inter-operable Planetary Data Access Protocol (PDAP) implementations [led by J. Salgado@ESA], (2) Small bodies interoperability [led by I. Shinohara@JAXA N. Hirata@U. Aizu], (3) PDAP assessment [led by Y. Yamamoto@JAXA], (4) Architecture and standards definition [led by D. Crichton@NASA], (5) Information model and data dictionary [led by S. Hughes@NASA], and (6) Venus Express Interoperability [led by N. Chanover@NMSU]. 'IPDA 2009-2010' is important, especially because the NASA/PDS system reformation is now reviewed as it develops for application at the international level. IPDA is the gate for the establishment of the future infrastructure. We are running 8 projects: (1) IPDA Assessment of PDS4 Data Standards [led by S. Hughes (NASA/JPL)], (2) IPDA Archive Guide [led by M.T. Capria (IASF/INAF) and D. Heather (ESA/PSA)], (3) IPDA Standards Identification [led by E. Rye (NASA/PDS) and G. Krishna (ISRO)], (4) Ancillary Data Standards [led by C. Acton (NASA/JPL)], (5) IPDA Registries Definition [led by D. Crichton (NASA/JPL)], (6) PDAP Specification [led by J. Salgado (ESA/PSA) and Y. Yamamoto (JAXA)], (7) In-teroperability Assessment [R. Beebe (NMSU) and D. Heather (ESA/PSA)], and (8) PDAP Geographic Information System (GIS) extension [N. Hirata (Univ. Aizu) and T. Hare (USGS: thare@usgs.gov)]. This paper presents our achievements and plans summarized in the IPDA 5th Steering Com-mittee meeting at DLR in July 2010. We are now just the gate for the establishment of the Infrastructure.

ESTEC/GEOVUSIE/ILEWG Planetary Student Designer Workshop: a Teacher Training Perspective

NASA Astrophysics Data System (ADS)

Preusterink, J.; Foing, B. H.; Kaskes, P.

2014-04-01

An important role for education is to inform and create the right skills for people to develop their own vision, using their talents to the utmost and inspire others to learn to explore in the future. Great effort has been taken to prepare this interactive design workshop thoroughly. Three days in a row, starting with presentations of Artscience The Hague to ESA colleagues, followed by a Planetary research Symposium in Amsterdam and a student design workshop at the end complemented a rich environment with the focus on Planetary exploration. The design workshop was organised by GeoVUsie students, with ESTEC and ILEWG support for tutors and inviting regional and international students to participate in an interactive workshop to design 5 Planetary Missions, with experts sharing their expertise and knowhow on specific challenging items: 1. Mercury - Post BepiColombo (with Sebastien Besse, ESA) 2. Moon South Pole Mission (with Bernard Foing, ESA) 3. Post-ExoMars - In search for Life on Mars (with Jorge Vago, ESA) 4. Humans in Space - Mars One investigated(with Arno Wielders, Space Horizon) 5. Europa - life on the icy moon of Jupiter? (with Bert Vermeersen, TU Delft. Lectures were given for more than 150 geology students at the symposium "Moon, Mars and More" at VU university, Amsterdam (organized by GeoVUsie earth science students). All students were provided with information before and at start for designing their mission. After the morning session there was a visit to the exhibition at The Erasmus Facility - ESTEC to inspire them even more with real artifacts of earlier and future missions into space. After this visit they prepared their final presentations, with original results, with innovative ideas and a good start to work out further in the future. A telescope session for geology students had been organized indoor due to rain. A follow-up visit to the nearby public Copernicus observatory was planned for another clear sky occasion.

The ESA SSA NEO Coordination Centre contribution to NEO hazard monitoring and observational campaigns

NASA Astrophysics Data System (ADS)

Micheli, Marco; Borgia, Barbara; Drolshagen, Gerhard; Koschny, Detlef; Perozzi, Ettore

2015-08-01

The NEO Coordination Centre (NEOCC) has recently been established in Frascati, near Rome, within the framework of the ESA Space Situational Awareness (SSA) Programme. Among its tasks is the coordination of observational activities related to the NEO hazard, and the distribution of relevant and up-to-date information on NEOs to both the scientific community and general users through its web portal (http://neo.ssa.esa.int).On the observational side, the NEOCC is linked to an increasingly large worldwide network of collaborating observatories, ranging from amateurs observers to large professional telescopes. The Centre organizes observation campaigns, alerting the network to suggest urgent or high-priority observations, and providing them with observational support.The NEOCC is also directly obtaining astrometric observations of high-priority targets, especially Virtual Impactors (VIs), on challenging objects as faint as magnitude 26.5, thanks to successful collaborations with ESO VLT in Chile and the INAF-sponsored LBT in Arizona. In addition, the Centre carries out regular monthly runs dedicated to NEO follow-up, recovery and survey activities with the 1-meter ESA OGS telescope in Tenerife.From a service perspective, the NEO System hosted at the NEOCC collects data and information on NEOs produced by various European services (e.g. NEODyS, EARN) and makes them available to a variety of users, with a particular focus on objects with possible collision solutions with the Earth. Among the tools provided through the web portal are the Risk List (a table of all known NEOs with impact solutions), a table of recent and upcoming close approaches, a database of physical properties of NEOs and the so-called Priority List, which allows observers to identify NEOs in most urgent need of observations, and prioritise their observational activities accordingly.The results of our recent observation campaigns and some major recent improvements to the NEO System will presented and discussed in detail.

A conjugated fatty acid present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD(+)/NADH ratio and activating PPARα, AMPK and SIRT1 signaling pathway.

PubMed

Chen, Gou-Chun; Su, Hui-Min; Lin, Yu-Shun; Tsou, Po-Yen; Chyuan, Jong-Ho; Chao, Pei-Min

2016-07-01

α-Eleostearic acid (α-ESA), or the cis-9, trans-11, trans-13 isomer of conjugated linolenic acid, is a special fatty acid present at high levels in bitter melon seed oil. The aim of this study was to examine the effect of α-ESA on hepatic lipid metabolism. Using H4IIEC3 hepatoma cell line, we showed that α-ESA significantly lowered intracellular triglyceride accumulation compared to α-linolenic acid (LN), used as a fatty acid control, in a dose- and time-dependent manner. The effects of α-ESA on enzyme activities and mRNA profiles in H4IIEC3 cells suggested that enhanced fatty acid oxidation and lowered lipogenesis were involved in α-ESA-mediated triglyceride lowering effects. In addition, α-ESA triggered AMP-activated protein kinase (AMPK) activation without altering sirtuin 1 (SIRT1) protein levels. When cells were treated with vehicle control (VC), LN alone (LN; 100μmol/L) or in combination with α-ESA (LN+α-ESA; 75+25μmol/L) for 24h, acetylation of forkhead box protein O1 was decreased, while the NAD(+)/NADH ratio, mRNA levels of NAMPT and PTGR1 and enzyme activity of nicotinamide phosphoribosyltransferase were increased by LN+α-ESA treatment compared to treatment with LN alone, suggesting that α-ESA activates SIRT1 by increasing NAD(+) synthesis and NAD(P)H consumption. The antisteatosis effect of α-ESA was confirmed in mice treated with a high-sucrose diet supplemented with 1% α-ESA for 5weeks. We conclude that α-ESA favorably affects hepatic lipid metabolism by increasing cellular NAD(+)/NADH ratio and activating PPARα, AMPK and SIRT1 signaling pathways. Copyright © 2016 Elsevier Inc. All rights reserved.

The NASA L3 Study

NASA Technical Reports Server (NTRS)

Stebbins, Robin

2016-01-01

The Astrophysics Implementation Plan calls for a minority role in L3, planned for launch in 2034. L3 The third large mission in ESAs Cosmic Visions 2015-2025 Programme NASA and ESA have been discussing a collaboration for 2 years Gravitational Observatory Advisory Team (GOAT) ESA study evaluating and recommend scientific performance tradeoffs, detection technologies, technology development activities, data analysis capabilities, schedule and cost US representatives: Guido Mueller, Mark Kasevich, Bill Klipstein, RTS Started in October 2014, concluding with a final report in late Marchor early April 2016. ESA solicited interest from ESA Member States in November 2015 NASA is continuing technology development support. ESA is restarting technology development activities.

The Effect of 2 Hz and 100 Hz Electrical Stimulation of Acupoint on Ankle Sprain in Rats

PubMed Central

2007-01-01

The electrical stimulation of acupoint (ESA) releases several endogenous neuropeptides, which play important roles in management of pain and inflammation. ESA with low and high frequencies has been shown to release different neuropepides, suggesting its various therapeutic effects. Pain and edema are major problems for ankle sprain. However, there have been few reports on the effects of ESA for ankle sprain. We aimed to investigate that ESA can reduce pain and edema resulting from ankle sprain, and whether there is a difference in therapeutic effects between low and high frequency ESA. To induce ankle sprain in Sprague-Dawley rats, the ankle of right hindpaw was overextended in direction of simultaneous inversion and plantar flexion. Stepping force and edema in the paw of the sprained ankle were measured by electronic balance and plethysmometer, respectively. In both 2 and 100 Hz ESA groups, stepping force was increased significantly in similar degrees (p<0.05). Only 2 Hz ESA produced the significant rapid decrease in ankle edema. This study demonstrates that ESA of 2 Hz and 100 Hz shows comparable analgesic effects, but only 2 Hz ESA can facilitate the reduction of edema caused by ankle sprain. PMID:17449948

Cross-Cultural Issues of Intra- and Inter-Organisational Cooperation in Space Operations: A Survey Study with Ground Personnel of the European Space Agency

NASA Astrophysics Data System (ADS)

Mjeldheim Sandal, Gro; Mjeldheim Sandal, Gro; Manzey, Dietrich

Today's space operations often involve close co-working of people with different ethnical, professional and organizational backgrounds. The aim of the study was to examine the implications of cultural diversity for efficient collaboration within the European Space Agency (ESA), and between ESA employees and representatives from other agencies. Methods: A web-based survey was answered by 905 employees at the European Astronaut Centre and at the European Space Technology Centre. An adapted version of the Flight Management Attitude Questionnaire by Helmreich and Merrit was used. Personnel were also asked about interpersonal and operational issues that interfered with efficient co-working within ESA and in relation to other space agencies. Results: Collaboration within ESA: A descriptive analysis was conducted of the rank orders of challenges perceived by members of different nationalities (the Netherlands (N=68), German (N=138), Italian (N=135), French (N=124), British (N=84) and Scandinavian (27).Rank orders show a surprisingly uniformity across nationalities. Most respondents perceived differences in the preferred leadership style as the main challenge for co-working in multi-national groups followed by differences in dealing with conflicts and misunderstandings. In contrast communication problems due different languages and differences in non-verbal behaviour, as well as differences in gender stereotypes were among the lowest rated issues. However, Scandinavian respondents showed a different pattern from other nationalities. Collaboration between agencies: The most significant issues reported to interfere with the efficiency of inter-agency collaboration varied. Most difficulties were reported in relation to clarity of communication, insufficient sharing of task related information, understanding the process of decision making in partner organization, and authoritarian leadership style in the partner organization Conclusion: Cultural differences in leadership and decision making processes are salient challenges in cooperation both within ESA and between ESA employees and representatives from other agencies. The importance given to these factors is consistent with results from the broader area of work and organizational psychology. Potential implications for safety operations are discussed

Operational support to collision avoidance activities by ESA's space debris office

NASA Astrophysics Data System (ADS)

Braun, V.; Flohrer, T.; Krag, H.; Merz, K.; Lemmens, S.; Bastida Virgili, B.; Funke, Q.

2016-09-01

The European Space Agency's (ESA) Space Debris Office provides a service to support operational collision avoidance activities. This support currently covers ESA's missions Cryosat-2, Sentinel-1A and -2A, the constellation of Swarm-A/B/C in low-Earth orbit (LEO), as well as missions of third-party customers. In this work, we describe the current collision avoidance process for ESA and third-party missions in LEO. We give an overview on the upgrades developed and implemented since the advent of conjunction summary messages (CSM)/conjunction data messages (CDM), addressing conjunction event detection, collision risk assessment, orbit determination, orbit and covariance propagation, process control, and data handling. We pay special attention to the effect of warning thresholds on the risk reduction and manoeuvre rates, as they are established through risk mitigation and analysis tools, such as ESA's Debris Risk Assessment and Mitigation Analysis (DRAMA) software suite. To handle the large number of CDMs and the associated risk analyses, a database-centric approach has been developed. All CDMs and risk analysis results are stored in a database. In this way, a temporary local "mini-catalogue" of objects close to our target spacecraft is obtained, which can be used, e.g., for manoeuvre screening and to update the risk analysis whenever a new ephemeris becomes available from the flight dynamics team. The database is also used as the backbone for a Web-based tool, which consists of the visualization component and a collaboration tool that facilitates the status monitoring and task allocation within the support team as well as communication with the control team. The visualization component further supports the information sharing by displaying target and chaser motion over time along with the involved uncertainties. The Web-based solution optimally meets the needs for a concise and easy-to-use way to obtain a situation picture in a very short time, and the support for third-party missions not operated from the European Space Operations Centre (ESOC). Finally, we provide statistics on the identified conjunction events, taking into account the known significant changes in the LEO orbital environment and share ESA's experience along with recent examples.

Lecture Notes and Essays in Astrophysics.III. 3rd Symposium of the Astrophysics Group of the Spanish Royal Physical Society (RSEF).

NASA Astrophysics Data System (ADS)

Ulla, A.; Manteiga, M.

2008-12-01

The Third volume of "Lecture Notes and Essays in Astrophysics" highlights some important contributions of Spanish astrophysicists to Planetology, Solar and Stellar Physics, Extragalactic Astronomy, Cosmology and astronomical instrumentation. After decades without a dedicated mission, Venus is again in fashion. On the one hand, Ricardo Hueso and collaborators, and on the other Miguel Angel Lopez-Valverde, review ESA Venus Express contribution to the understanding of the atmosphere of the neighbouring planet. Carme Jordi describes in a comprehensive essay the main observational calibration techniques and methods for the determination of mass, radius, temperature, chemical composition and luminosity of a star. Dying stars are fundamental to understand the nature of dark energy, probably the most fundamental problem in Physics today. Type Ia supernovae have played a fundamental role showing the acceleration of the expansion rate of the Universe a decade ago. Inma Dominguez and collaborators go into detail on how the knowledge of the fundamental physics of thermonuclear supernovae explotions condition their role as astrophysical candles.

75 FR 63379 - Technical Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

... previously resided with the Employment Standards Administration (ESA), which has now been dissolved. DATES... both programs to OWCP, one of ESA's sub-agencies. On November 8, 2009, the Secretary dissolved ESA into...-dissolved ESA and to clarify the Secretary's delegation of authority for the administration of the LHWCA and...

Comparative Effectiveness of Biosimilar, Reference Product and Other Erythropoiesis-Stimulating Agents (ESAs) Still Covered by Patent in Chronic Kidney Disease and Cancer Patients: An Italian Population-Based Study.

PubMed

Ingrasciotta, Ylenia; Giorgianni, Francesco; Marcianò, Ilaria; Bolcato, Jenny; Pirolo, Roberta; Chinellato, Alessandro; Ientile, Valentina; Santoro, Domenico; Genazzani, Armando A; Alibrandi, Angela; Fontana, Andrea; Caputi, Achille P; Trifirò, Gianluca

2016-01-01

Since 2007 biosimilars of erythropoiesis-stimulating agents (ESAs) are available on the Italian market. Very limited post-marketing data exist on the comparative effectiveness of biosimilar and originator ESAs. This population-based study was aimed to compare the effects of biosimilars, reference product and other ESAs still covered by patent on hemoglobinemia in chronic kidney disease (CKD) and cancer patients in a Local Health Unit (LHU) from Northern Italy. A retrospective cohort study was conducted during the years 2009-2014 using data from Treviso LHU administrative database. Incident ESA users (no ESA dispensing within 6 months prior to treatment start, i.e. index date (ID)) with at least one hemoglobin measurement within one month prior to ID (baseline Hb value) and another measurement between 2nd and 3rd month after ID (follow-up Hb value) were identified. The strength of the consumption (as total number of defined daily dose (DDD) dispensed during the follow-up divided by days of follow-up) and the difference between follow-up and baseline Hb values [delta Hb (ΔHb)] were evaluated. Based on Hb changes, ESA users were classified as non-responders (ΔHb≤0 g/dl), responders (0<ΔHb≤2 g/dl), and highly responders (ΔHb>2 g/dl). A multivariate ordinal logistic regression model to identify predictors for responsiveness to treatment was performed. All analyses were stratified by indication for use and type of dispensed ESA at ID. Overall, 1,003 incident ESA users (reference product: 252, 25.1%; other ESAs covered by patent: 303, 30.2%; biosimilars: 448, 44.7%) with CKD or cancer were eligible for the study. No statistically significant difference in the amount of dose dispensed during the follow-up among biosimilars, reference product and other ESAs covered by patent was found in both CKD and cancer. After three months from treatment start, all ESAs increased Hb values on average by 2g/dl. No differences in ΔHb as well as in frequency of non-responders, responders and highly responders among different types of ESAs were observed in both indications of use. Overall, around 15-20% of ESA users were non-responders. Strength of treatment, but no type of dispensed ESAs was found to be predictor of responsiveness to treatment. No difference on the effects on hemoglobinemia among users of either biosimilars or reference product or ESAs covered by patent was observed in a general population from Northern Italy, despite a comparable dispensed dose of the different ESAs during the first three months of treatment.

ESA's Integral satellite ready for lift-off from Baikonur

NASA Astrophysics Data System (ADS)

2002-10-01

ESA's INTEGRAL (International Gamma Ray Astrophysics Laboratory) satellite, will be launched by a Proton launcher from Baikonur, Kazakhstan on 17 October at 06:41 CEST (Central European Summer Time). The most sensitive gamma-ray observatory ever launched, INTEGRAL is a truly international mission involving all ESA member states plus the USA and Russia. It carries four instruments from teams led by scientists in Italy, France, Germany, Denmark and Spain to gather and analyse gamma-rays, X-rays and visible light from celestial objects. INTEGRAL will give astronomers across the world their clearest views yet of the most extreme environments in the Universe. It will detect radiation from the most violent events far away and from processes that made the Universe inhabitable. Media representatives in Europe can follow the videotransmission of the launch at ESA/Darmstadt (ESOC) in Germany, which will be acting as the main European press centre, ESA/Noordwijk (ESTEC) in the Netherlands, ESA/Frascati (ESRIN) in Italy or ESA/Villafranca (VILSPA) in Spain. At each site ESA specialists will be available for interviews. Media representatives wishing to attend are requested to complete the attached reply form and fax it to the Communication Office at the establishment of their choice. The ESA TV Service will provide video news releases and live coverage of the launch between 06:15-07:00 and 08:00-08:30 CEST. Details of the transmission schedule for the various Video News Releases can be found on http://television.esa.int The launch can also be followed live on the internet at www.esa.int/integrallaunch starting at 06:15 hrs.

Forecasting the Range-wide Status of Polar Bears at Selected Times in the 21st Century

Treesearch

Steven C. Amstrup; Bruce G. Marcot; David C. Douglas

2007-01-01

To inform the U.S. Fish and Wildlife Service decision whether or not to list polar bears as threatened under the Endangered Species Act (ESA), we forecast the status of the world's polar bear (Ursus maritimus) populations 45, 75 and 100 years into the future. We applied the best available information about predicted changes in sea ice in the...

Use of Information--LMC Connection

ERIC Educational Resources Information Center

Darrow, Rob

2005-01-01

Note taking plays an important part in the correct extracting of information from reference sources. The "Cornell Note Taking Method" initially developed as a method of taking notes during a lecture is well suited for taking notes from print sources and is one of the best "Use of Information" methods.

The ESA standard for telemetry and telecommand packet utilisation: PUS

NASA Technical Reports Server (NTRS)

Kaufeler, Jean-Francois

1994-01-01

ESA has developed standards for packet telemetry and telecommand, which are derived from the recommendations of the Inter-Agency Consultative Committee for Space Data Systems (CCSDS). These standards are now mandatory for future ESA programs as well as for many programs currently under development. However, while these packet standards address the end-to-end transfer of telemetry and telecommand data between applications on the ground and Application Processes on-board, they leave open the internal structure or content of the packets. This paper presents the ESA Packet Utilization Standard (PUS) which addresses this very subject and, as such, serves to extend and complement the ESA packet standards. The goal of the PUS is to be applicable to future ESA missions in all application areas (Telecommunications, Science, Earth Resources, microgravity, etc.). The production of the PUS falls under the responsibility of the ESA Committee for Operations and EGSE Standards (COES).

Environmental Politics and the Endangered Species Act.

ERIC Educational Resources Information Center

Sahr, David

2000-01-01

Explores the controversial issue of the Endangered Species Act (ESA) discussing the Act and the scope of the extinction problem. Reviews the arguments for and against the ESA, addresses the tactics that have been used in the political struggle over the ESA, and highlights the future of the ESA. Includes teaching activities. (CMK)

Balancing ESA and iron therapy in a prospective payment environment.

PubMed

Aronoff, George R; Gaweda, Adam E

2014-02-01

Ever since the introduction of EPO, ESAs and iron dosing have been driven by financial incentives. When ESAs were a profit center for providers, large doses were used. With ESAs becoming a cost center, a new trend has appeared, gradually replacing their use with iron to achieve the same therapeutic effect at lower cost. This financially driven approach, treating ESAs and iron as alternatives, is not consistent with human physiology where these agents act in a complementary manner. It is likely that we are still giving unnecessarily large doses of ESAs and iron, relative to what our patients' true needs are. Although we have highlighted the economic drivers of this outcome, many other factors play a role. These include our lack of understanding of the complex interplay of the anemia of chronic disease, inflammation, poor nutrition, blood loss through dialysis, ESAs and iron deficiency. We propose that physiology-driven modeling may provide some insight into the interactions between erythropoiesis and ferrokinetics. This insight can then be used to derive new, physiologically compatible dosing guidelines for ESAs and iron.

SCOS 2: ESA's new generation of mission control system

NASA Technical Reports Server (NTRS)

Jones, M.; Head, N. C.; Keyte, K.; Howard, P.; Lynenskjold, S.

1994-01-01

New mission-control infrastructure is currently being developed by ESOC, which will constitute the second generation of the Spacecraft Control Operations system (SCOS 2). The financial, functional and strategic requirements lying behind the new development are explained. The SCOS 2 approach is described. The technological implications of these approaches is described: in particular it is explained how this leads to the use of object oriented techniques to provide the required 'building block' approach. The paper summarizes the way in which the financial, functional and strategic requirements have been met through this combination of solutions. Finally, the paper outlines the development process to date, noting how risk reduction was achieved in the approach to new technologies and summarizes the current status future plans.

Associations between hematopoietic growth factors and risks of venous thromboembolism, stroke, ischemic heart disease and myelodysplastic syndrome: findings from a large population-based cohort of women with breast cancer.

PubMed

Du, Xianglin L; Zhang, Yefei; Hardy, Dale

2016-05-01

To determine the risk of venous thromboembolism (VTE), stroke, ischemic heart disease, and myelodysplastic syndrome (MDS) in association with the receipt of colony-stimulating factors (CSFs) and/or erythropoiesis-stimulating agents (ESAs) in women with breast cancer. We studied 77,233 women with breast cancer aged ≥65 in 1992-2009 from the Surveillance, Epidemiology, and End Results-Medicare linked data with up to 19 years of follow-up. Incidence of VTE increased from 9 cases in women receiving no chemotherapy and no CSFs/ESAs to 22.79 cases per 1,000 person-years in those receiving chemotherapy with CSFs and ESAs. Women with chemotherapy who received both CSFs and ESAs (adjusted hazard ratio and 95 % confidence interval 2.01, 1.80-2.25) or received ESAs without CSFs (2.03, 1.74-2.36) were twice as likely to develop VTE than those receiving no chemotherapy and no CSFs/ESAs, whereas those receiving CSF alone without ESA were 64 % more likely to have VTE (1.64, 1.45-1.85). Risk of MDS was significantly increased by fivefold in patients receiving ESA following chemotherapy. Receipts of CSFs and ESAs were significantly associated with an increased risk of VTE in women with breast cancer. Use of ESAs was significantly associated with substantially increased risks of MDS. These findings support those of previous studies.

Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin

PubMed Central

Sato, Yuichiro; Morimoto, Kinjiro; Kubo, Takanori; Sakaguchi, Takemasa; Nishizono, Akira; Hirayama, Makoto; Hori, Kanji

2015-01-01

Lectin sensitivity of the recent pandemic influenza A virus (H1N1-2009) was screened for 12 lectins with various carbohydrate specificity by a neutral red dye uptake assay with MDCK cells. Among them, a high mannose (HM)-binding anti-HIV lectin, ESA-2 from the red alga Eucheuma serra, showed the highest inhibition against infection with an EC50 of 12.4 nM. Moreover, ESA-2 exhibited a wide range of antiviral spectrum against various influenza strains with EC50s of pico molar to low nanomolar levels. Besides ESA-2, HM-binding plant lectin ConA, fucose-binding lectins such as fungal AOL from Aspergillus oryzae and AAL from Aleuria aurantia were active against H1N1-2009, but the potency of inhibition was of less magnitude compared with ESA-2. Direct interaction between ESA-2 and a viral envelope glycoprotein, hemagglutinin (HA), was demonstrated by ELISA assay. This interaction was effectively suppressed by glycoproteins bearing HM-glycans, indicating that ESA-2 binds to the HA of influenza virus through HM-glycans. Upon treatment with ESA-2, no viral antigens were detected in the host cells, indicating that ESA-2 inhibited the initial steps of virus entry into the cells. ESA-2 would thus be useful as a novel microbicide to prevent penetration of viruses such as HIV and influenza viruses to the host cells. PMID:26035023

Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction

PubMed Central

Obitsu, S; Sakata, K; Teshima, R; Kondo, K

2013-01-01

RIP1 is a serine/threonine kinase, which is involved in apoptosis and necroptosis. In apoptosis, caspase-8 and FADD have an important role. On the other hand, RIP3 is a key molecule in necroptosis. Recently, we reported that eleostearic acid (ESA) elicits caspase-3- and PARP-1-independent cell death, although ESA-treated cells mediate typical apoptotic morphology such as chromatin condensation, plasma membrane blebbing and apoptotic body formation. The activation of caspases, Bax and PARP-1, the cleavage of AIF and the phosphorylation of histone H2AX, all of which are characteristics of typical apoptosis, do not occur in ESA-treated cells. However, the underlying mechanism remains unclear. To clarify the signaling pathways in ESA-mediated apoptosis, we investigated the functions of RIP1, MEK, ERK, as well as AIF. Using an extensive study based on molecular biology, we identified the alternative role of RIP1 in ESA-mediated apoptosis. ESA mediates RIP1-dependent apoptosis in a kinase independent manner. ESA activates serine/threonine phosphatases such as calcineurin, which induces RIP1 dephosphorylation, thereby ERK pathway is activated. Consequently, localization of AIF and ERK in the nucleus, ROS generation and ATP reduction in mitochondria are induced to disrupt mitochondrial cristae, which leads to cell death. Necrostatin (Nec)-1 blocked MEK/ERK phosphorylation and ESA-mediated apoptosis. Nec-1 inactive form (Nec1i) also impaired ESA-mediated apoptosis. Nec1 blocked the interaction of MEK with ERK upon ESA stimulation. Together, these findings provide a new finding that ERK and kinase-independent RIP1 proteins are implicated in atypical ESA-mediated apoptosis. PMID:23788031

Influence of safety warnings on ESA prescribing among dialysis patients using an interrupted time series

PubMed Central

2013-01-01

Background In March, 2007, a black box warning was issued by the Food and Drug Administration (FDA) to use the lowest possible erythropoiesis-stimulating agents (ESA) doses for treatment of anemia associated with renal disease. The goal is to determine if a change in ESA use was observed following the warning among US dialysis patients. Methods ESA therapy was examined from September 2004 through August 2009 (thirty months before and after the FDA black box warning) among adult Medicare hemodialysis patients. An interrupted time series model assessed the impact of the warnings. Results The FDA black box warning did not appear to influence ESA prescribing among the overall dialysis population. However, significant declines in ESA therapy after the FDA warnings were observed for selected populations. Patients with a hematocrit ≥36% had a declining month-to-month trend before (−164 units/week, p = <0.0001) and after the warnings (−80 units/week, p = .001), and a large drop in ESA level immediately after the black box (−4,744 units/week, p = <.0001). Not-for-profit facilities had a declining month-to-month trend before the warnings (−90 units/week, p = .009) and a large drop in ESA dose immediately afterwards (−2,487 units/week, p = 0.015). In contrast, for-profit facilities did not have a significant change in ESA prescribing. Conclusions ESA therapy had been both profitable for providers and controversial regarding benefits for nearly two decades. The extent to which a FDA black box warning highlighting important safety concerns influenced use of ESA therapy among nephrologists and dialysis providers was unknown. Our study found no evidence of changes in ESA prescribing for the overall dialysis population resulting from a FDA black box warning. PMID:23927675

Effectiveness of Switch to Erythropoiesis-Stimulating Agent (ESA) Biosimilars versus Maintenance of ESA Originators in the Real-Life Setting: Matched-Control Study in Hemodialysis Patients.

PubMed

Minutolo, Roberto; Bolasco, Piergiorgio; Chiodini, Paolo; Sposini, Stefano; Borzumati, Maurizio; Abaterusso, Cataldo; Mele, Alessandra A; Santoro, Domenico; Canale, Valeria; Santoboni, Alberto; Filiberti, Oliviero; Fiorini, Fulvio; Mura, Carlo; Imperiali, Patrizio; Borrelli, Silvio; Russo, Luigi; De Nicola, Luca; Russo, Domenico

2017-10-01

In hemodialysis (HD), switching from erythropoiesis-stimulating agent (ESA) originators to biosimilars is associated with the need for doses approximately 10% higher, according to industry-driven studies. The aim of this study was to evaluate the efficacy on anemia control of switching from ESA originators to biosimilars in daily clinical practice. We retrospectively selected consecutive HD patients receiving stable intravenous ESA doses, and who had not been transfused in the previous 6 months, from 12 non-profit Italian centers. Patients switched from originators to biosimilars (n = 163) were matched with those maintained on ESA originators (n = 163) using a propensity score approach. The study duration was 24 weeks, and the primary endpoint was the mean dose difference (MDD), defined as the difference between the switch and control groups of ESA dose changes during the study (time-weighted average ESA dose minus baseline ESA dose). Age (70 ± 13 years), male sex (63%), diabetes (29%), history of cardiovascular disease (40%), body weight (68 ± 14 kg), vascular access (86% arteriovenous fistula), hemoglobin [Hb] (11.2 ± 0.9 g/dL) and ESA dose (8504 ± 6370 IU/week) were similar in the two groups. Hb remained unchanged during the study in both groups. Conversely, ESA dose remained unchanged in the control group and progressively increased in the switch group from week 8 to 24. The time-weighted average of the ESA dose was higher in the switch group than in the control group (10,503 ± 7389 vs. 7981 ± 5858 IU/week; p = 0.001), leading to a significant MDD of 2423 IU/week (95% confidence interval [CI] 1615-3321), corresponding to a 39.6% (95% CI 24.7-54.6) higher dose of biosimilars compared with originators. The time-weighted average of Hb was 0.2 g/dL lower in the switch group, with a more frequent ESA hyporesponsiveness (14.7 vs. 2.5%). Iron parameters and other resistance factors remained unchanged. In stable dialysis patients, switching from ESA originators to biosimilars requires 40% higher doses to maintain anemia control.

Erythropoiesis-stimulating agent use among non-dialysis-dependent CKD patients before and after the trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT) using a large US health plan database.

PubMed

Thamer, Mae; Zhang, Yi; Kshirsagar, Onkar; Cotter, Dennis J; Kaufman, James S

2014-11-01

In a landmark study, TREAT (Trial to Reduce Cardiovascular Events With Aranesp Therapy) examined the use of erythropoiesis-stimulating agent (ESA) therapy to treat anemia among patients with chronic kidney disease (CKD) and found no benefit compared to placebo. A retrospective observational design was used to determine the impact of TREAT on clinical practice. A large US health plan database with more than 1.2 million claims for patients with non-dialysis-dependent CKD stages 3 and 4. ESA prescribing 2 years before and after publication of TREAT. Rate of ESA prescribing for ESA-naive and -prevalent cohorts. (1) Monthly ESA prescribing in the 2 years before and after publication of TREAT (ordinary least squares regression), (2) adjusted likelihood of prescribing ESA after TREAT (clustered logistic regression), and (3) probability of receiving ESA therapy based on anemia status (χ(2) test). For patients with CKD stage 3, the proportion prescribed ESA therapy declined from 17% pre-TREAT to 11% post-TREAT (a 38% decline), and for those with CKD stage 4, from 34% to 27% (a 22% decline). Prescribing of ESA therapy was declining even before TREAT, but the decline accelerated in the post-TREAT period (stage 3: change of slope, -0.08 [P<0.001]; stage 4: change of slope, -0.16 [P<0.001]). ESA prescribing declined after TREAT regardless of anemia status; among patients with hemoglobin levels <10g/dL, only 25% of patients with CKD stage 3 and 33% of patients with stage 4 were prescribed ESAs 2 years after TREAT, a notable 50% decline. After adjusting for all covariates, the probability of prescribing ESAs was 35% lower during the 2-year period after versus before publication of TREAT (OR, 0.65; 95% CI, 0.63-0.67). The cumulative effect of adverse safety concerns in the period before TREAT also influenced physician prescribing of ESA therapy and could not be separated from the influence of TREAT. TREAT appears to be a watershed study that was followed by a marked decline in ESA prescribing for patients with CKD. Copyright © 2014 National Kidney Foundation, Inc. All rights reserved.

Sentinel-2a: multi-spectral instrument first in-orbit performance

NASA Astrophysics Data System (ADS)

Fernandez, Valerie; Isola, Claudia; Hoersch, Bianca; Gascon, Ferran; Tréma, Thierry

2017-09-01

Copernicus is a European Union (EU) led initiative designed to establish a European capacity for the provision and use of operational monitoring information for environment and security applications. Within the Copernicus program, ESA is responsible for the development of the Space Component and Ground Segment..

Freshwater Fish Assemblage Patterns in Rhode Island Streams and Rivers (ESA)

EPA Science Inventory

Patterns in fish assemblages in streams and rivers can inform watershed and water management, yet these patterns are not well characterized for the U.S. state of Rhode Island. Here we relate freshwater fish data collected by the Rhode Island Department of Environmental Managemen...

A year after lift-off, XMM-Newton is impressing the X-ray astronomy community

NASA Astrophysics Data System (ADS)

2000-11-01

XMM-Newton was launched from Kourou on 10 December 1999 on the first Ariane-5 commercial flight. After in-orbit commissioning of the spacecraft, and calibration and performance verification of its science instruments, the observatory entered its routine operations phase on 1 July. At the press conference, ESA's Director of Science Prof. Roger-Maurice Bonnet and XMM-Newton Project Scientist Fred Jansen will present some of the many scientific results from the first eight months of the mission. Also present will be two of Europe's foremost X-ray astronomers, Prof. Johan Bleeker of the Space Research Organisation of the Netherlands, and Prof. Guenther Hasinger of the Astrophysikalisches Institut Potsdam, Germany. Amongst the topics to be illustrated with some remarkably vivid "colour" images of the X-ray Universe, will be XMM-Newton's first examination of a cataclysmic binary star, its first insights into some enigmatic black hole systems, analysis of the morphology of a few supernovae remnants, and evidence it has collected to end the long-standing mystery over X-ray cosmic background emission... The press conference will also recap on the spacecraft's operations, the performance of its science instruments, the issue of radiation constraints and future aspects of the mission. Media representatives wishing to attend the press event are kindly invited to complete the attached reply form and fax it back to ESA Media Relations Office +33(0)1.53.69.7690. Note to editors XMM-Newton is ESA's second Cornerstone Mission of the Horizon 2000 programme. The spacecraft was built by a European consortium of companies led by Astrium (formerly Dornier Satellitensysteme), Friedrichshafen, Germany. Its X-ray imaging and spectrographic instruments (EPIC and RGS) and its optical telescope (OM) were provided by large consortia, whose principal investigators are from, respectively, the University of Leicester, UK, SRON University of Utrecht Netherlands, and the Mullard Space Science Laboratory, UK.

VizieR Online Data Catalog: Gaia DR1 (Gaia Collaboration, 2016)

NASA Astrophysics Data System (ADS)

Gaia Collaboration

2016-06-01

Gaia DR1 is based on observations collected between 25 July 2014 and 16 September 2015. Gaia DR1 contains positions (RA,DE) and G magnitudes for all sources with acceptable formal standard errors on positions. Positions and individual uncertainties are computed using a generic prior and Bayes' rule (detailed description in "Gaia astrometry for stars with too few observations. A Bayesian approach", Michalik et al., 2015A&A...583A..68M). The five-parameter astrometric solution - positions, parallaxes, and proper motions - for stars in common between the Tycho-2 Catalogue and Gaia is contained in Gaia DR1. This part of Gaia DR1 is based on the Tycho-Gaia Astrometric Solution (paper with detailed description (Michalik et al., 2015A&A...574A.115M); paper describing theory and background (Michalik et al., 2014A&A...571A..85M); paper describing quasar extension (Michalik & Lindegren, 2016A&A...586A..26M)). At the beginning of the routine phase, for a period of 4 weeks, a special scanning mode repeatedly covering the ecliptic poles on every spin was executed for calibration purposes. Photometric data of selected RR Lyrae and Cepheid variable stars based on these high-cadence measurements are contained in Gaia DR1. Positions (RA,DE) and G magnitudes for 2152 ICRF quasars (F. Mignard et al., 2016, A&A, in press.). The Gaia Archive DR1 data is available at archives.esac.esa.int/gaia. Tgas and Gaia Sources can be downloaded as VOTables, FITS or CSV at http://cdn.gea.esac.esa.int/Gaia/ If you use public Gaia DR1 data in your paper, please take note of our guide on how to acknowledge and cite Gaia DR1: http://gaia.esac.esa.int/documentation/GDR1/Miscellaneous/\\ seccreditandcitationinstructions.html (9 data files).

Detecting clinically relevant new information in clinical notes across specialties and settings.

PubMed

Zhang, Rui; Pakhomov, Serguei V S; Arsoniadis, Elliot G; Lee, Janet T; Wang, Yan; Melton, Genevieve B

2017-07-05

Automated methods for identifying clinically relevant new versus redundant information in electronic health record (EHR) clinical notes is useful for clinicians and researchers involved in patient care and clinical research, respectively. We evaluated methods to automatically identify clinically relevant new information in clinical notes, and compared the quantity of redundant information across specialties and clinical settings. Statistical language models augmented with semantic similarity measures were evaluated as a means to detect and quantify clinically relevant new and redundant information over longitudinal clinical notes for a given patient. A corpus of 591 progress notes over 40 inpatient admissions was annotated for new information longitudinally by physicians to generate a reference standard. Note redundancy between various specialties was evaluated on 71,021 outpatient notes and 64,695 inpatient notes from 500 solid organ transplant patients (April 2015 through August 2015). Our best method achieved at best performance of 0.87 recall, 0.62 precision, and 0.72 F-measure. Addition of semantic similarity metrics compared to baseline improved recall but otherwise resulted in similar performance. While outpatient and inpatient notes had relatively similar levels of high redundancy (61% and 68%, respectively), redundancy differed by author specialty with mean redundancy of 75%, 66%, 57%, and 55% observed in pediatric, internal medicine, psychiatry and surgical notes, respectively. Automated techniques with statistical language models for detecting redundant versus clinically relevant new information in clinical notes do not improve with the addition of semantic similarity measures. While levels of redundancy seem relatively similar in the inpatient and ambulatory settings in the Fairview Health Services, clinical note redundancy appears to vary significantly with different medical specialties.

The European Astronaut Centre prepares for International Space Station operations.

PubMed

Messerschmid, E; Haignere, J P; Damian, K; Damann, V

2004-04-01

The European Space Agency (ESA) contribution to the International Space Station (ISS) goes much beyond the delivery of hardware like the Columbus Laboratory, its payloads and the Automated Transfer Vehicles. ESA Astronauts will be members of the ISS crew. ESA, according to its commitments as ISS international partner, will be responsible to provide training on its elements and payloads to all ISS crewmembers and medical support for ESA astronauts. The European Astronaut Centre (EAC) in Cologne has developed over more than a decade into the centre of expertise for manned space activities within ESA by contributing to a number of important co-operative spaceflight missions. This role will be significantly extended for ISS manned operations. Apart from its support to ESA astronauts and their onboard operations, EAC will have a key role in training all ISS astronauts on ESA elements and payloads. The medical support of ISS crew, in particular of ESA astronauts has already started. This paper provides an overview on status and further plans in building up this homebase function for ESA astronauts and on the preparation towards Training Readiness for ISS crew training at EAC, Cologne. Copyright 2001 by the European Space Agency. Published by the American Institute of Aeronautics and Astronautics, Inc., with permission. Released to IAF/IAA/AIAA to publish in all forms. c2003 Elsevier Ltd. All rights reserved.

Use of Erythropoietin-Stimulating Agents (ESA) in Patients With End-Stage Renal Failure Decided to Forego Dialysis: Palliative Perspective.

PubMed

Cheng, Hon Wai Benjamin; Chan, Kwok Ying; Lau, Hoi To; Man, Ching Wah; Cheng, Suk Ching; Lam, Carman

2017-05-01

Normochromic normocytic anemia is a common complication in chronic kidney disease (CKD) and is associated with many adverse clinical consequences. Erythropoiesis-stimulating agents (ESAs) act to replace endogenous erythropoietin for patients with end-stage renal disease having anemia. Today, ESAs remain the main tool for treating anemia associated with CKD. In current practice, the use of ESA is not limited to the patients on renal replacement therapy but has extended to nondialysis patients under palliative care (PC). Current evidence on ESA usage in patients with CKD decided to forego dialysis often have to take reference from studies conducted in other groups of patients with CKD, including pre-dialysis patients and those on renal replacement therapy. There is paucity of studies targeting use of ESAs in renal PC patients. Small-scale retrospective study in renal PC patients had suggested clinical advantage of ESAs in terms of hemoglobin improvement, reduction in fatigue, and hospitalization rate. With the expected growth in elderly patients with CKD decided to forego dialysis and manage conservatively, there remains an urgent need to call for large-scale prospective trial in exploring efficacy of ESAs in this population, targeting on quality of life and symptoms improvement outcome. This article also reviews the mechanism of action, pharmacology, adverse effects, and clinical trial evidence for ESA in patients with CKD under renal PC.

Bundled-rate legislation for Medicare reimbursement for dialysis services: implications for anemia management with ESAs.

PubMed

Charytan, Chaim

2010-12-01

With the incidence of ESRD on the rise, there is a continuing need to control anemia-related treatment costs in dialysis patients receiving reimbursement through Medicare. Currently, erythropoiesis-stimulating agents (ESAs) are billed separately from dialysis services, potentially creating little financial incentive for more efficient use. The Medicare Improvement for Patients and Providers Act, passed by the U.S. Congress in July 2008, includes provisions intended to address this concern. Under this act, dialysis services will be reimbursed using a fully bundled, comprehensive payment system that includes all services currently covered in the basic composite rate, as well as certain separately billable items, including ESAs. A base rate of $229.63 per treatment has been assigned, to be individualized using case-mix adjusters. The implications of this new system for anemia management with ESAs continue to be elucidated. With fixed compensation for ESAs, management strategies that maximize efficiencies and, thereby, optimize cost savings will be favored. Select strategies may include switching from intravenous (IV) to subcutaneous routes, lowering Hb targets and ESA doses in hyporesponsive patients, increasing administration of IV iron, increasing use of home dialysis, and optimizing ESA dosing intervals. Once-monthly ESA therapy has potential advantages under this new system as an alternative to more frequently administered ESAs and may help achieve quality metrics in a cost-efficient manner.

De novo weekly and biweekly darbepoetin alfa dosing in pediatric patients with chronic kidney disease.

PubMed

Warady, Bradley A; Barcia, John; Benador, Nadine; Jankauskiene, Augustina; Olson, Kurt; Podracka, Ludmila; Shavkin, Aleksey; Srivaths, Poyyapakkam; Wong, Cynthia J; Petersen, Jeffrey

2018-01-01

Darbepoetin alfa is a commonly prescribed erythropoiesis-stimulating agent (ESA) for correcting anemia in pediatric chronic kidney disease (CKD) patients. However, little information exists on its use in ESA-naïve patients. This study evaluated the efficacy and safety of darbepoetin alfa in pediatric patients initiating ESA therapy. One-hundred sixteen pediatric ESA-naïve subjects (aged 1-18 years) with CKD stages 3-5D and hemoglobin (Hb) <10 g/dl from 43 centers in the US, Europe, and Mexico were randomized by age (three groups) and dialysis status (yes vs. no) to receive darbepoetin alfa once weekly (QW) or every 2 weeks (Q2W) subcutaneously (not on dialysis and peritoneal dialysis subjects) and intravenously (hemodialysis subjects). The drug was titrated to achieve Hb levels of 10.0-12.0 g/dl over 25 weeks. Patient- and parent-reported health-related outcomes were measured by the Pediatric Quality of Life Inventory (PedsQL™) in children ≥2 years. In both groups, mean Hb concentrations increased to ≥11.0 g/dl over the first 3 months of treatment and remained stable within the 10.0-12.0 g/dl target range. The median time to achieve hemoglobin ≥10 g/dl was slightly longer for subjects <12 years (QW and Q2W, both 28 days) vs. those ≥12 years (23 and 22 days, respectively). Adverse event profiles were similar between groups, with QW, four (7%) and Q2W, five (9%). PedsQL™ scores showed modest increases. Darbepoetin alfa can be safely administered either QW or Q2W to ESA-naïve pediatric patients with CKD-related anemia to achieve Hb targets of 10.0-12.0 g/dl.

Hubble Space Telescope Celebrates 25 Years of Unveiling the Universe

NASA Image and Video Library

2015-04-23

This visualization provides a three-dimensional perspective on Hubble's 25th anniversary image of the nebula Gum 29 with the star cluster Westerlund 2 at its core. The flight traverses the foreground stars and approaches the lower left rim of the nebula Gum 29. Passing through the wispy darker clouds on the near side, the journey reveals bright gas illuminated by the intense radiation of the newly formed stars of cluster Westerlund 2. Within the nebula, several pillars of dark, dense gas are being shaped by the energetic light and strong stellar winds from the brilliant cluster of thousands of stars. Note that the visualization is intended to be a scientifically reasonable interpretation and that distances within the model are significantly compressed. Download here: hubblesite.org/newscenter/archive/releases/2015/12/video/ Credit: NASA, ESA, G. Bacon, L. Frattare, Z. Levay, and F. Summers (Viz3D Team, STScI), and J. Anderson (STScI) Acknowledgment: The Hubble Heritage Team (STScI/AURA), A. Nota (ESA/STScI), the Westerlund 2 Science Team, and ESO NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

First Orbital Solution for the Non-thermal Emitter Cyg OB2 No. 9

NASA Astrophysics Data System (ADS)

Nazé, Y.; Damerdji, Y.; Rauw, G.; Kiminki, D. C.; Mahy, L.; Kobulnicky, H. A.; Morel, T.; De Becker, M.; Eenens, P.; Barbieri, C.

2010-08-01

After the first detection of its binary nature, the spectroscopic monitoring of the non-thermal radio emitter Cyg OB2 No. 9 (P = 2.4 yr) has continued, doubling the number of available spectra of the star. Since the discovery paper of 2008, a second periastron passage has occurred in 2009 February. Using a variety of techniques, the radial velocities could be estimated and a first, preliminary orbital solution was derived from the He I λ5876 line. The mass ratio appears close to unity and the eccentricity is large, i.e., 0.7-0.75. X-ray data from 2004 and 2007 are also analyzed in quest of peculiarities linked to binarity. The observations reveal neither large overluminosity nor strong hardness, but it must be noted that the high-energy data were taken after the periastron passage, at a time where colliding wind emission may be low. Some unusual X-ray variability is however detected, with a 10% flux decrease between 2004 and 2007. To clarify their origin and find a more obvious signature of the wind-wind collision, additional data, taken at periastron and close to it, are needed. Based on observations collected at the Haute-Provence Observatory and with XMM-Newton, an ESA Science Mission with instruments and contributions directly funded by ESA Member States and the USA (NASA).

Spacecraft Fire Safety Demonstration

NASA Technical Reports Server (NTRS)

Urban, David L.; Ruff, Gary A.

2016-01-01

A presentation of the Saffire Experiment goals and scientific objectives for the Joint CSA/ESA/JAXA/NASA Increments 47 and 48 Science Symposium. The purpose of the presentation is to inform the ISS Cadre and the other investigators of the Saffire goals and objectives to enable them to best support a successful Saffire outcome.

Econo-ESA in semantic text similarity.

PubMed

Rahutomo, Faisal; Aritsugi, Masayoshi

2014-01-01

Explicit semantic analysis (ESA) utilizes an immense Wikipedia index matrix in its interpreter part. This part of the analysis multiplies a large matrix by a term vector to produce a high-dimensional concept vector. A similarity measurement between two texts is performed between two concept vectors with numerous dimensions. The cost is expensive in both interpretation and similarity measurement steps. This paper proposes an economic scheme of ESA, named econo-ESA. We investigate two aspects of this proposal: dimensional reduction and experiments with various data. We use eight recycling test collections in semantic text similarity. The experimental results show that both the dimensional reduction and test collection characteristics can influence the results. They also show that an appropriate concept reduction of econo-ESA can decrease the cost with minor differences in the results from the original ESA.

Examining Emotional Support Animals and Role Conflicts in Professional Psychology

PubMed Central

Younggren, Jeffrey N.; Boisvert, Jennifer A.; Boness, Cassandra L.

2016-01-01

This article examines the role conflicts that psychologists may face in their practices related to the evaluation and certification of emotional support animals (ESAs). It reviews the legal differences between ESAs and service animals (SAs), outlines ethical guidelines and legal policies/regulations regarding the use of ESAs, and examines the potential role conflicts that exist when a treating psychologist is certifying the need for an ESA. Finally, it makes recommendations to assist psychologists in staying within the standards of practice in order to avoid the ethical and legal risks associated with certifying an ESA. PMID:27909384

Examining Emotional Support Animals and Role Conflicts in Professional Psychology.

PubMed

Younggren, Jeffrey N; Boisvert, Jennifer A; Boness, Cassandra L

2016-08-01

This article examines the role conflicts that psychologists may face in their practices related to the evaluation and certification of emotional support animals (ESAs). It reviews the legal differences between ESAs and service animals (SAs), outlines ethical guidelines and legal policies/regulations regarding the use of ESAs, and examines the potential role conflicts that exist when a treating psychologist is certifying the need for an ESA. Finally, it makes recommendations to assist psychologists in staying within the standards of practice in order to avoid the ethical and legal risks associated with certifying an ESA.

Reflections of ions in electrostatic analyzers: A case study with New Horizons/Solar Wind Around Pluto

NASA Astrophysics Data System (ADS)

Randol, B. M.; Ebert, R. W.; Allegrini, F.; McComas, D. J.; Schwadron, N. A.

2010-11-01

Electrostatic analyzers (ESAs), in various forms, are used to measure plasma in a range of applications. In this article, we describe how ions reflect from the interior surfaces of an ESA, the detection of which constitutes a fundamentally nonideal response of ESAs. We demonstrate this effect by comparing laboratory data from a real ESA-based space instrument, the Solar Wind Around Pluto (SWAP) instrument, aboard the NASA New Horizons spacecraft, to results from a model based on quantum mechanical simulations of particles reflected from the instrument's surfaces combined with simulations of particle trajectories through the instrument's applied electrostatic fields. Thus, we show, for the first time, how reflected ions in ESAs lead to nonideal effects that have important implications for understanding the data returned by these instruments, as well as for designing new low-background ESA-based instruments. Specifically, we show that the response of SWAP widens considerably below a level of 10-3 of the peak response. Thus, a direct measurement of a plasma distribution with SWAP will have an energy-dependent background on the order of <=10-3 of the peak of the signal due to that distribution. We predict that this order of magnitude estimate for the background applies to a large number of ESA-based instruments because ESAs operate using a common principle. However, the exact shape of the energy-dependent response will be different for different instruments. The principle of operation is that ions outside the ideal range of energy-per-charge are deflected into the walls of the ESA. Therefore, we propose that a new design paradigm is necessary to mitigate the effect of ion reflections and thus accurately and directly measure the energy spectrum of a plasma using ESAs. In this article, we build a framework for minimizing the effect of ion reflections in the design of new ESAs. Through the use of existing computer simulation software, a design team can use our method to quantify the amount of reflections in their instrument and iteratively change design parameters before fabrication, conserving resources. A possible direction for the new design paradigm is having nonsolid walls of the ESA, already used in some applications.

Using language models to identify relevant new information in inpatient clinical notes.

PubMed

Zhang, Rui; Pakhomov, Serguei V; Lee, Janet T; Melton, Genevieve B

2014-01-01

Redundant information in clinical notes within electronic health record (EHR) systems is ubiquitous and may negatively impact the use of these notes by clinicians, and, potentially, the efficiency of patient care delivery. Automated methods to identify redundant versus relevant new information may provide a valuable tool for clinicians to better synthesize patient information and navigate to clinically important details. In this study, we investigated the use of language models for identification of new information in inpatient notes, and evaluated our methods using expert-derived reference standards. The best method achieved precision of 0.743, recall of 0.832 and F1-measure of 0.784. The average proportion of redundant information was similar between inpatient and outpatient progress notes (76.6% (SD=17.3%) and 76.7% (SD=14.0%), respectively). Advanced practice providers tended to have higher rates of redundancy in their notes compared to physicians. Future investigation includes the addition of semantic components and visualization of new information.

Using Language Models to Identify Relevant New Information in Inpatient Clinical Notes

PubMed Central

Zhang, Rui; Pakhomov, Serguei V.; Lee, Janet T.; Melton, Genevieve B.

2014-01-01

Redundant information in clinical notes within electronic health record (EHR) systems is ubiquitous and may negatively impact the use of these notes by clinicians, and, potentially, the efficiency of patient care delivery. Automated methods to identify redundant versus relevant new information may provide a valuable tool for clinicians to better synthesize patient information and navigate to clinically important details. In this study, we investigated the use of language models for identification of new information in inpatient notes, and evaluated our methods using expert-derived reference standards. The best method achieved precision of 0.743, recall of 0.832 and F1-measure of 0.784. The average proportion of redundant information was similar between inpatient and outpatient progress notes (76.6% (SD=17.3%) and 76.7% (SD=14.0%), respectively). Advanced practice providers tended to have higher rates of redundancy in their notes compared to physicians. Future investigation includes the addition of semantic components and visualization of new information. PMID:25954438

"Heart" of Herschel to be presented to media

NASA Astrophysics Data System (ADS)

2007-09-01

The Herschel mission, equipped with the largest telescope ever launched in space (3.5 m diameter), will give astronomers their best capability yet to explore the universe at far-infrared and sub-millimetre wavelengths. By measuring the light at these wavelengths, scientists see the ‘cold’ universe. Herschel will give them an unprecedented view, allowing them to see deep into star forming regions, galactic centres and planetary systems. In order to achieve its objectives and to be able to detect the faint radiation coming from the coolest objects in the cosmos, otherwise ‘invisible’, Herschel’s detectors must operate at very low and stable temperatures. The spacecraft is equipped so as to cool them close to absolute zero (-273.15 ºC), ranging from -271 ºC to only a few tenths of a degree above absolute zero. To have achieved this particular feature alone is a remarkable accomplishment for European industry and science. The final integration of the various components of the Herschel spacecraft - payload module, cryostat, service module, telescope and solar arrays - will be completed in the next few months. This phase will be followed by a series of tests to get the spacecraft ready for launch at the end of July 2008. Herschel will be launched into space on an Ariane 5 ECA rocket. The launch is shared with Planck, ESA’s mission to study relic radiation from the Big Bang. Media interested to attend the press event are invited to fill in the reply form below. Note for editors The Prime Contractor for the Herschel spacecraft is Thales Alenia Space (Cannes, France). It leads a consortium of industrial partners with Astrium (Germany) responsible for the Extended Payload Module (EPLM, including the Herschel cryostat), Astrium (France) responsible for the telescope, and the Thales Alenia Space industry branch of Torino, Italy, responsible for the Service Module (SVM). There is also a host of subcontractors spread throughout Europe. The three Herschel instruments were designed and built by consortia of scientists and institutes, with their own national funding. The Photodetector Array Camera and Spectrometer (PACS) was developed under the coordination of the MPE, Germany; the Spectral and Photometric Imaging Receiver (SPIRE) was developed under the coordination of the Cardiff University (United Kingdom); the Heterodyne Instrument for the Far Infrared (HIFI) was developed under the coordination of the SRON institute (The Netherlands). For more information ESA Media Relations Office Tel: +33(0)1.53.69.7299 Fax: +33(0)1.53.69.7690 Herschel Press Day at Astrium, Friedrichshafen, Germany 19 September 2007 Claude-Dornier-Strasse 88090 Immenstaad 09:00 h Arrival at Astrium /Check-in / Transfer to Building 8 / Room Meersburg (5 th floor) 09:30 h Welcome, by Uwe Minne, Director of Earth Observation and Science, Astrium 09:35 h ESA and Astronomy: looking forward, by Jacques Louet, Head of Scientific Projects Department, ESA 09:45 h Herschel/Planck mission overview, by Thomas Passvogel, ESA Herschel/Planck Project Manager 09:55 h The Herschel scientific mission, by Göran Pilbratt, ESA Herschel Project Scientist 10:05 h Q & A followed by coffee break 10:30 h Herschel spacecraft overview, by Jean-Jacques Julliet, Director of European Science and Optical Observation Programmes, Thales Alenia Space 10:40 h The ‘cool’ heart of Herschel, by Wolfgang Fricke, Herschel Project Manager, Astrium 10:50 h The PACS instrument, by Albrecht Poglitsch, Principal Investigator, Max-Planck-Institut für extraterrestrische Physik (MPE) 11:00 h The SPIRE instrument, by Matthew Griffin, Principal Investigator, Cardiff University 11:10 h The HIFI instrument, by Thijs de Graauw, Principal Investigator, Netherlands Institute for Space Research (SRON) 11:20 h Q & A, Individual Interviews 12:15 h Transfer to Integration Centre 12:30 h Warm / Cold Buffet on Visitoŕs Galaxy Build up of three different visitor groups Check-in into cleanroom Photo/video opportunity/interviews (3 groups, 30 min. each) 14:00 h End of event

Elements of ESA's policy on space and security

NASA Astrophysics Data System (ADS)

Giannopapa, Christina; Adriaensen, Maarten; Antoni, Ntorina; Schrogl, Kai-Uwe

2018-06-01

In the past decade Europe has been facing rising security threats, ranging from climate change, migrations, nearby conflicts and crises, to terrorism. The demand to tackle these critical challenges is increasing in Member States. Space is already contributing, and could further contribute with already existing systems and future ones. The increasing need for security in Europe and for safety and security of Europe's space activities has led to a growing number of activities in ESA in various domains. It has also driven new and strengthened partnerships with security stakeholders in Europe. At the European level, ESA is collaborating closely with the main European institutions dealing with space security. In addition, as an organisation ESA has evolved to conduct security-related projects and programmes and to address the threats to its own activities, thereby securing the investments of the Member States. Over the past years the Agency has set up a comprehensive regulatory framework in order to be able to cope with security related requirements. Over the past years, ESA has increased its exchanges with its Member States. The paper presents main elements of the ESA's policy on space and security. It introduces the current European context for space and security, the European goals in this domain and the specific objectives to which the Agency intends to contribute. Space and security in the ESA context is set out under two components: a) security from space and b) security in space, including the security of ESA's own activities (corporate security and the security of ESA's space missions). Subsequently, ESA's activities are elaborated around these two pillars, composed of different activities conducted in the most appropriate frameworks and in coordination with the relevant stakeholders and shareholders.

Rasch analysis of the Edmonton Symptom Assessment System and research implications.

PubMed

Cheifetz, O; Packham, T L; Macdermid, J C

2014-04-01

Reliable and valid assessment of the disease burden across all forms of cancer is critical to the evaluation of treatment effectiveness and patient progress. The Edmonton Symptom Assessment System (esas) is used for routine evaluation of people attending for cancer care. In the present study, we used Rasch analysis to explore the measurement properties of the esas and to determine the effect of using Rasch-proposed interval-level esas scoring compared with traditional scoring when evaluating the effects of an exercise program for cancer survivors. Polytomous Rasch analysis (Andrich's rating-scale model) was applied to data from 26,645 esas questionnaires completed at the Juravinski Cancer Centre. The fit of the esas to the polytomous Rasch model was investigated, including evaluations of differential item functioning for sex, age, and disease group. The research implication was investigated by comparing the results of an observational research study previously analysed using a traditional approach with the results obtained by Rasch-proposed interval-level esas scoring. The Rasch reliability index was 0.73, falling short of the desired 0.80-0.90 level. However, the esas was found to fit the Rasch model, including the criteria for uni-dimensional data. The analysis suggests that the current esas scoring system of 0-10 could be collapsed to a 6-point scale. Use of the Rasch-proposed interval-level scoring yielded results that were different from those calculated using summarized ordinal-level esas scores. Differential item functioning was not found for sex, age, or diagnosis groups. The esas is a moderately reliable uni-dimensional measure of cancer disease burden and can provide interval-level scaling with Rasch-based scoring. Further, our study indicates that, compared with the traditional scoring metric, Rasch-based scoring could result in substantive changes to conclusions.

A European patient record study on diagnosis and treatment of chemotherapy-induced anaemia.

PubMed

Ludwig, Heinz; Aapro, M; Bokemeyer, C; Glaspy, J; Hedenus, M; Littlewood, T J; Österborg, A; Rzychon, B; Mitchell, D; Beguin, Y

2014-08-01

Patients with cancer frequently experience chemotherapy-induced anaemia (CIA) and iron deficiency. Erythropoiesis-stimulating agents (ESAs), iron supplementation and blood transfusions are available therapies. This study evaluated routine practice in CIA management. Medical oncologists and/or haematologists from nine European countries (n=375) were surveyed on their last five cancer patients treated for CIA (n=1,730). Information was collected on tests performed at diagnosis of anaemia, levels of haemoglobin (Hb), serum ferritin and transferrin saturation (TSAT), as well as applied anaemia therapies. Diagnostic tests and therapies for CIA varied across Europe. Anaemia and iron status were mainly assessed by Hb (94%) and ferritin (48%) measurements. TSAT was only tested in 14%. At anaemia diagnosis, 74% of patients had Hb ≤ 10 g/dL, including 15% with severe anaemia (Hb <8 g/dL). Low-iron levels (ferritin ≤ 100 ng/mL) were detected in 42% of evaluated patients. ESA was used in 63%of patients, blood transfusions in 52 % and iron supplementation in 31% (74% oral, 26% intravenous iron). Only 30% of ESA-treated patients received a combination of ESA and iron supplementation. Blood transfusions formed part of a regular anaemia treatment regimen in 76% of transfused patients. Management practices were similar in 2009 and 2011. Management of anaemia and iron status in patients treated for CIA varies substantially across Europe. Iron status is only assessed in half of the patients. In contrast to clinical evidence, iron treatment is under utilised and mainly based on oral iron supplementation. Implementation of guidelines needs to be increased to minimize the use of blood transfusions.

The new Planetary Science Archive (PSA): Exploration and discovery of scientific datasets from ESA's planetary missions

NASA Astrophysics Data System (ADS)

Martinez, Santa; Besse, Sebastien; Heather, Dave; Barbarisi, Isa; Arviset, Christophe; De Marchi, Guido; Barthelemy, Maud; Docasal, Ruben; Fraga, Diego; Grotheer, Emmanuel; Lim, Tanya; Macfarlane, Alan; Rios, Carlos; Vallejo, Fran; Saiz, Jaime; ESDC (European Space Data Centre) Team

2016-10-01

The Planetary Science Archive (PSA) is the European Space Agency's (ESA) repository of science data from all planetary science and exploration missions. The PSA provides access to scientific datasets through various interfaces at http://archives.esac.esa.int/psa. All datasets are scientifically peer-reviewed by independent scientists, and are compliant with the Planetary Data System (PDS) standards. The PSA is currently implementing a number of significant improvements, mostly driven by the evolution of the PDS standard, and the growing need for better interfaces and advanced applications to support science exploitation. The newly designed PSA will enhance the user experience and will significantly reduce the complexity for users to find their data promoting one-click access to the scientific datasets with more specialised views when needed. This includes a better integration with Planetary GIS analysis tools and Planetary interoperability services (search and retrieve data, supporting e.g. PDAP, EPN-TAP). It will be also up-to-date with versions 3 and 4 of the PDS standards, as PDS4 will be used for ESA's ExoMars and upcoming BepiColombo missions. Users will have direct access to documentation, information and tools that are relevant to the scientific use of the dataset, including ancillary datasets, Software Interface Specification (SIS) documents, and any tools/help that the PSA team can provide. A login mechanism will provide additional functionalities to the users to aid / ease their searches (e.g. saving queries, managing default views). This contribution will introduce the new PSA, its key features and access interfaces.

ESA's Food Security Thematic Exploitation Platform "Supporting Sustainable Food Production from Space"

NASA Astrophysics Data System (ADS)

Gilliams, S. J.

2017-12-01

In line with the paradigm shift in Earth Observation of "Bringing the users to the data", ESA provides collaborative, virtual work environments giving access to EO data and tools, processors, and ICT resources through coherent interfaces. These coherent interfaces are categorized thematically, tailored to the related user communities and named Thematic Exploitation Platforms (TEP). The Food Security Thematic Exploitation Platform (FS-TEP) is the youngest out of seven TEPs and is developed in an agile mode in close coordination with its users. It will provide a "one stop platform" for the extraction of information from EO data for services in the food security sector mainly in Europe & Africa, allowing both access to EO data and processing of these data sets. Thereby it will foster smart, data-intensive agricultural and aquacultural applications in the scientific, private and public domain. The FS-TEP builds on a large and heterogeneous user community, spanning from application developers in agriculture to aquaculture, from small-scale farmers to agricultural industry, from public science to the finance and insurance sectors, from local and national administration to international agencies. To meet the requirements of these groups, the FS-TEP will provide different frontend interfaces. Service pilots will demonstrate the platform's ability to support agriculture and aquaculture with tailored EO based information services.The project team developing the FS-TEP and implementing pilot services during a 30 months period (started in April 2017) is led by Vista GmbH, Germany, supported by CGI Italy, VITO, Belgium, and Hatfield Consultants, Canada. It is funded by ESA under contract number 4000120074/17/I-EF.

Athena Community Office

NASA Astrophysics Data System (ADS)

Martínez-Núnez, S.; Barcons, X.; Barret, D.; Bozzo, E.; Carrera, F. J.; Ceballos, M. T.; Gómez, S.; Monterde, M. P.; Rau, A.

2017-03-01

The Athena Community Office (ACO) has been established by ESA's Athena Science Study Team (ASST) in order to obtain support in performing its tasks assigned by ESA, and most specially in the ASST role as "focal point for the interests of the broad scientific community". The ACO is led by the Instituto de Física de Cantabria (CSIC-UC), and its activities are funded by CSIC and UC. Further ACO contributors are the University of Geneva, MPE and IRAP. In this poster, we present ACO to the Spanish Astronomical Community, informing about its main responsibilities, which are: assist the ASST in organising and collecting support from the Athena Working Groups and Topical Panels; organise and maintain the documentation generated by the Athena Working Groups and Topical Panels; manage the Working Group and Topical Panel membership lists; assist the ASST in promoting Athena science capabilities in the research world, through conferences and workshops; keep a record of all papers and presentations related to Athena; support the production of ASST documents; produce and distribute regularly an Athena Newsletter, informing the community about all mission and science developments; create and maintain the Athena Community web portal; maintain an active communication activity; promote, organise and support Athena science-related public outreach, in coordination with ESA and other agencies involved when appropriate; and, design, produce materials and provide pointers to available materials produced by other parties. In summary, ACO is meant to become a focal point to facilitate the scientific exchange between the Athena activities and the scientific community at large, and to disseminate the Athena science objectives to the general public.

The New Planetary Science Archive (PSA): Exploration and Discovery of Scientific Datasets from ESA's Planetary Missions

NASA Astrophysics Data System (ADS)

Heather, David; Besse, Sebastien; Vallat, Claire; Barbarisi, Isa; Arviset, Christophe; De Marchi, Guido; Barthelemy, Maud; Coia, Daniela; Costa, Marc; Docasal, Ruben; Fraga, Diego; Grotheer, Emmanuel; Lim, Tanya; MacFarlane, Alan; Martinez, Santa; Rios, Carlos; Vallejo, Fran; Saiz, Jaime

2017-04-01

The Planetary Science Archive (PSA) is the European Space Agency's (ESA) repository of science data from all planetary science and exploration missions. The PSA provides access to scientific datasets through various interfaces at http://psa.esa.int. All datasets are scientifically peer-reviewed by independent scientists, and are compliant with the Planetary Data System (PDS) standards. The PSA is currently implementing a number of significant improvements, mostly driven by the evolution of the PDS standard, and the growing need for better interfaces and advanced applications to support science exploitation. As of the end of 2016, the PSA is hosting data from all of ESA's planetary missions. This includes ESA's first planetary mission Giotto that encountered comet 1P/Halley in 1986 with a flyby at 800km. Science data from Venus Express, Mars Express, Huygens and the SMART-1 mission are also all available at the PSA. The PSA also contains all science data from Rosetta, which explored comet 67P/Churyumov-Gerasimenko and asteroids Steins and Lutetia. The year 2016 has seen the arrival of the ExoMars 2016 data in the archive. In the upcoming years, at least three new projects are foreseen to be fully archived at the PSA. The BepiColombo mission is scheduled for launch in 2018. Following that, the ExoMars Rover Surface Platform (RSP) in 2020, and then the JUpiter ICy moon Explorer (JUICE). All of these will archive their data in the PSA. In addition, a few ground-based support programmes are also available, especially for the Venus Express and Rosetta missions. The newly designed PSA will enhance the user experience and will significantly reduce the complexity for users to find their data promoting one-click access to the scientific datasets with more customized views when needed. This includes a better integration with Planetary GIS analysis tools and Planetary interoperability services (search and retrieve data, supporting e.g. PDAP, EPN-TAP). It will also be up-to-date with versions 3 and 4 of the PDS standards, as PDS4 will be used for ESA's ExoMars and upcoming BepiColombo missions. Users will have direct access to documentation, information and tools that are relevant to the scientific use of the dataset, including ancillary datasets, Software Interface Specification (SIS) documents, and any tools/help that the PSA team can provide. The new PSA interface was released in January 2017. The home page provides a direct and simple access to the scientific data, aiming to help scientists to discover and explore its content. The archive can be explored through a set of parameters that allow the selection of products through space and time. Quick views provide information needed for the selection of appropriate scientific products. During 2017, the PSA team will focus their efforts on developing a map search interface using GIS technologies to display ESA planetary datasets, an image gallery providing navigation through images to explore the datasets, and interoperability with international partners. This will be done in parallel with additional metadata searchable through the interface (i.e., geometry), and with a dedication to improve the content of 20 years of space exploration.

Determining Primary Care Physician Information Needs to Inform Ambulatory Visit Note Display

PubMed Central

Clarke, M.A.; Steege, L.M.; Moore, J.L.; Koopman, R.J.; Belden, J.L.; Kim, M.S.

2014-01-01

Summary Background With the increase in the adoption of electronic health records (EHR) across the US, primary care physicians are experiencing information overload. The purpose of this pilot study was to determine the information needs of primary care physicians (PCPs) as they review clinic visit notes to inform EHR display. Method Data collection was conducted with 15 primary care physicians during semi-structured interviews, including a third party observer to control bias. Physicians reviewed major sections of an artificial but typical acute and chronic care visit note to identify the note sections that were relevant to their information needs. Statistical methods used were McNemar-Mosteller’s and Cochran Q. Results Physicians identified History of Present Illness (HPI), Assessment, and Plan (A&P) as the most important sections of a visit note. In contrast, they largely judged the Review of Systems (ROS) to be superfluous. There was also a statistical difference in physicians’ highlighting among all seven major note sections in acute (p = 0.00) and chronic (p = 0.00) care visit notes. Conclusion A&P and HPI sections were most frequently identified as important which suggests that physicians may have to identify a few key sections out of a long, unnecessarily verbose visit note. ROS is viewed by doctors as mostly “not needed,” but can have relevant information. The ROS can contain information needed for patient care when other sections of the Visit note, such as the HPI, lack the relevant information. Future studies should include producing a display that provides only relevant information to increase physician efficiency at the point of care. Also, research on moving A&P to the top of visit notes instead of having A&P at the bottom of the page is needed, since those are usually the first sections physicians refer to and reviewing from top to bottom may cause cognitive load. PMID:24734131

Determination of alachlor and its sulfonic acid metabolite in water by solid-phase extraction and enzyme-linked immunosorbent assay

USGS Publications Warehouse

Aga, D.S.; Thurman, E.M.; Pomes, M.L.

1994-01-01

Solid-phase extraction (SPE) and enzyme-linked immunosorbent assay (ELISA) were combined for the trace analysis of the herbicide alachlor and its major soil metabolite, ethanesulfonic acid (ESA). The anti-alachlor antibody cross-reacted with ESA, which produced false-positive detections of alachlor in water samples by immunoassay screens. Alachlor and ESA were isolated from water by SPE on a C18 resin and eluted sequentially with ethyl acetate and methanol. Alachlor is soluble in ethyl acetate while the anionic ESA is not. Thus ESA remained adsorbed on the C18 resin and was eluted later with methanol. The combination of SPE with ELISA effectivety separated and quantified both alachlor and ESA using the same antibody for two ELISA methods. The general method may have applicability for the separation of other herbicides and their ionic metabolites. The SPE-ELISA method has a, detection limit of 0.01 ??g/L for alachlor and 0.05 ??g/L for ESA, with a precision of ?? 10%. Analyses of surface and ground water samples were confirmed by gas chromatography/mass spectrometry and high-performance liquid chromatography with photodiode-array detection. Results showed widespread occurrence of ESA in surface and ground water of the midwestern United States, with concentrations ranging from 10 ??g/L.

Physician Information Needs and Electronic Health Records (EHRs): Time to Reengineer the Clinic Note.

PubMed

Koopman, Richelle J; Steege, Linsey M Barker; Moore, Joi L; Clarke, Martina A; Canfield, Shannon M; Kim, Min S; Belden, Jeffery L

2015-01-01

Primary care physicians face cognitive overload daily, perhaps exacerbated by the form of electronic health record documentation. We examined physician information needs to prepare for clinic visits, focusing on past clinic progress notes. This study used cognitive task analysis with 16 primary care physicians in the scenario of preparing for office visits. Physicians reviewed simulated acute and chronic care visit notes. We collected field notes and document highlighting and review, and we audio-recorded cognitive interview while on task, with subsequent thematic qualitative analysis. Member checks included the presentation of findings to the interviewed physicians and their faculty peers. The Assessment and Plan section was most important and usually reviewed first. The History of the Present Illness section could provide supporting information, especially if in narrative form. Physicians expressed frustration with the Review of Systems section, lamenting that the forces driving note construction did not match their information needs. Repetition of information contained in other parts of the chart (eg, medication lists) was identified as a source of note clutter. A workflow that included a patient summary dashboard made some elements of past notes redundant and therefore a source of clutter. Current ambulatory progress notes present more information to the physician than necessary and in an antiquated format. It is time to reengineer the clinic progress note to match the workflow and information needs of its primary consumer. © Copyright 2015 by the American Board of Family Medicine.

NASA and ESA Partnership on the Multi-Purpose Crew Vehicle Service Module

NASA Technical Reports Server (NTRS)

Schubert, Kathleen E.; Grantier, Julie A.

2012-01-01

(1) ESA decided in its Council Meeting in March 2011 to partially offset the European ISS obligations after 2015 with different means than ATVs; (2) The envisioned approach is based on a barter element(s) that would generate cost avoidance on the NASA side; (3) NASA and ESA considered a number of Barter options, NASA concluded that the provision by ESA of the Service Module for the NASA Multi-Purpose Crew Vehicle (MPCV) was the barter with the most interest;. (4) A joint ESA - NASA working group was established in May 2011 to assess the feasibility of Europe developing this Module based on ATV heritage; (5)The working group was supported by European and US industry namely Astrium, TAS-I and Lockheed-Martin; and (6) The project is currently in phase B1 with the objective to prepare a technical and programmatic proposal for an ESA MPCV-SM development. This proposal will be one element of the package that ESA plans submit to go forward for approval by European Ministers in November 2012.

Hipparcos pinpoints an amazing gamma-ray clock

NASA Astrophysics Data System (ADS)

1998-01-01

Following a preliminary report at a symposium on Hipparcos results in Venice in May, the full story of the pinpointing of Geminga is told in a paper to be published in Astronomy and Astrophysics in January 1998. Patrizia Caraveo of the Istituto di Fisica Cosmica in Milan is the lead author, and other astronomers in Milan, Turin, Garching, Copenhagen and Noordwijk contributed to this aspect of the work (see footnote). The result made it possible to to use the observation of gamma-ray pulses to time the rotation of Geminga with extreme accuracy, as described in a paper by John Mattox of Boston University, Jules Halpern of Columbia University, and Patrizia Caraveo. It is due to appear in the Astrophysical Journal in February 1998, and is already accessible on the Internet. Geminga is a unique object: a highly compressed, spinning neutron star which does not emit radio beeps like the well-known pulsars. Yet it is a powerful source of pulsating gamma-rays and X-rays. Geminga is probably the prototype of millions of radio-silent neutron stars in the Milky Way Galaxy, so far unrecognized. "We needed Hipparcos to finish a long and complicated task of tracking down Geminga," Patrizia Caraveo comments. "Never was so faint an object pinpointed so precisely. Now we can say that we have more exact knowledge on the position of Geminga than of any other 'classical' neutron star -- even the famous Crab pulsar." Closing in on Geminga When first observed in a systematic way by COS-B, Geminga's place in the sky was known only to within half a degree -- an uncertainty in position as wide as the Moon. X-ray observations by other satellites narrowed the field and led to the detection of Geminga by visible light, as an extremely faint star. Last year, the same Milan-based Italian team was able to determine the distance of Geminga at 500 light-years, by a succession of observations with the Hubble Space Telescope (see ESA Information Note 04-96). The next task was precisely to situate a Hubble Space Telescope image, including Geminga, within a much wider field of stars. The Hubble image was only one-hundredth of a degree wide, but to find enough Hipparcos stars for accurate positioning required a region more than a degree wide, as seen in a photographic plate obtained with an astrometric telescope at Turin Observatory. This plate included four stars from the Hipparcos Catalogue (118,000 stars plotted with the highest precision) and fifteen more from the Tycho Catalogue (a million stars plotted from Hipparcos data with somewhat less precision). To link the widest and the narrowest images, four intermediate steps were needed. Two other starfields from Turin, half a degree wide and one-sixth of a degree wide, zoomed in towards the location of a starfield from the New Technology Telescope (NTT) of the European Southern Observatory at La Silla, Chile, one-26th of a degree wide. Within the NTT image lay Geminga and the location of the Hubble image. The Hipparcos/Tycho stars in the widest field served to fix the positions of a number of other stars within the next image, and these in turn became the references for fixing other stars within the third image -- and so on, until references in the NTT image pinned down some of the background stars in the Hubble Geminga image. In this precise work, corrections had to be made for the slight motions of the reference stars across the sky in the interval between the first (1984) and the last (1996) of the images in the series. To complicate the task, Geminga itself is travelling at 120 km per second in a northeasterly direction. The astronomers are now able to declare that on 17 March 1995 (the date of the Hubble image), Geminga was at the celestial longitude of 98.47563 degrees and celestial latitude (or declination) of + 17.77025 degrees within the Hipparcos Reference Frame. The uncertainty in the figures is only +/- 1 in the last decimal place. Taking Geminga's pulse Geminga rotates like a lighthouse, flashing a beam of gamma-rays and X-rays towards the Earth 252 times a minute. The first detection of pulsations in Geminga's emissions came from the German-US-UK Rosat X-ray satellite in 1992. NASA's Compton gamma-ray observatory detected the same pulses in gamma-rays and observed them for several years up to 1996. Re-examination of the gamma-ray counts for Geminga, from NASA's SAS-2 satellite (1972-73) and ESA's COS-B satellite (1975-82) led to the detection of the same pulses retrospectively. Astronomers then had the tantalizing prospect of reconstructing, from sporadic periods of observations, every tick of Geminga's clock over 24 years, 1972-1996. Positioning Geminga accurately enough was the remaining hurdle. The gamma-ray clock seems to run fast or slow depending on the Earth's motion in orbit. At the end of March each year the Earth, and any attendant gamma-ray satellites, are travelling towards Geminga in the constellation Gemini at about 30 kilometres per second. Geminga's timekeeping speeds up by 9 seconds a day. Six months later, on the other side of the Sun, the Earth is receding at the same speed, and Geminga's pulses seem slower by the same amount. To correct completely for this seasonal effect required the more exact position of Geminga provided by Hipparcos data. Motions in Earth orbit of the SAS-2, COS-B and Compton spacecraft at the times of the intermittent gamma-ray observations also had to be taken into account. The outcome is a coherent 24.2-year reconstruction of more than 3 billion rotations of Geminga. "The Hipparcos result allowed us to correct for the effect of the Earth's motion," comments John Mattox of Boston. "It is also fortunate that a major glitch in the rotation of Geminga has not occurred. Some pulsars often suffer internal rearrangements or starquakes that change their rotation rates suddenly. Instead we see a gradual spindown as Geminga radiates its rotational energy." Created by the collapse of the core of an exploding star about 300,000 years ago, Geminga has no renewable source of energy. Nevertheless it is more luminous in its gamma-rays and X-rays than the Sun is by visible light. Interaction between the spinning neutron star and a surrounding magnetosphere of ionized gas powers the emissions, by extracting energy from the rotation and slowing the star down. The new timings suggest that Geminga is like a watch that loses less than one less than one microsecond a year. But the rate of slowdown is increasing faster than expected by comparison with other young pulsars. Does Geminga possess a planet? Another puzzle concerns a slight rhythmic change in the pulse-rate of Geminga, in a cycle of 5 years, seen most clearly in the recent Compton observations. While this could be a fluke due to errors in the rather sparse data, a physical explanation could be the presence of a planet with about twice the mass of the Earth orbiting around the neutron star every 5 years, and causing it to wobble. ESA's framework for astronomy Michael Perryman, ESA's project scientist for the Hipparcos mission, is a co-author of the Hipparcos-Geminga report in Astronomy and Astrophysics. He sees the multiplicity of instruments and wavelengths used in the Geminga study as an illustration of the overarching role of Hipparcos. "The results from Hipparcos provide a framework for every branch of astronomy and bring new precision to all of them," Perryman comments."Hipparcos never saw Geminga, because it is far too faint. Yet when used to calibrate other observations in visible light, the Hipparcos and Tycho Catalogues give a position for Geminga far more accurate than could ever be expected from the X-ray and gamma-ray observations alone. Similarly Hipparcos relates the entire Universe seen by radio and infrared telescopes to the local frame of bright stars." Other ESA astronomy missions besides Hipparcos have played key roles in the Geminga saga, starting with the gamma-ray satellite COS-B in the 1970s, and continuing with the sharp observations by the NASA-ESA Hubble Space Telescope, seeing Geminga as a faint visible star. The story will broaden into a hunt for other silent neutron stars like Geminga, using ESA's super-sensitive X-ray astronomy satellite XMM, due to be launched in 1999. Two years later XMM will be followed into orbit by Integral, ESA's successor to COS-B as a gamma-ray astronomy satellite of vastly enhanced performance. Another Hipparcos-Geminga co-author is Giovanni Bignami. He named Geminga in 1976 and has hunted it, with his colleagues in Milan, for more than 20 years. (In the Milanese argot, "ghèminga" means "it's not there" and referred to Geminga's invisibility at radio wavelengths.) Bignami is a principal investigator in the XMM mission, and is director for science in the Agenzia Spatiale Italiana, Rome. "Geminga is a shining example of how multinational collaboration in astronomy pays off," Bignami says. "We in Europe have done very well out of ESA in space astronomy, and also in our collaborations in ground observatories. We have world-class facilities that none of our home countries could offer us on their own. While governments ponder ESA's future role in science they should sense the surge of excitement throughout Europe, as astronomers beat all expectations in using the superb opportunities that come from ESA membership." For further information, please contact: Michael Perryman (Hipparcos project): +31 7156 53615 Patrizia Caraveo (currently in Rome): +39 6 440 4327 Simon Vermeer (ESA PR, Paris): +33 1 5369 7155 Note 1. The full authorship of the Hipparcos-Geminga paper in Astronomy and Astrophysics is: P.A. Caraveo (IFC, Milan), M.G. Lattanzi (OAT, Turin), G. Massone (OAT, Turin), R.P. Mignani (MPE, Garching), V.V. Makarov (CUO, Copenhagen), M.A.C. Perryman (ESA, Noordwijk) and G.F. Bignami (ASI, Rome). Note 2. A postscript version of the Geminga timing paper for the Astrophysical Journal is accessible on the www at: http://bu-ast.bu.edu/~mattox/geminga.html

Programmatic overview of GMES Space Component and implementation status

NASA Astrophysics Data System (ADS)

Aschbacher, Josef; Milagro, Maria Pilar

2010-05-01

GMES, the Global Monitoring for Environment and Security initiative, is a programme to provide the most comprehensive understanding of the state of land, air and water. Created in 1998 as an independent joint initiative of the European Commission (EC) and the European Space Agency (ESA), GMES will combine information from the world's biggest fleet of satellites and from thousands of atmospheric and Earth based sensors across the world in order to provide joined-up, timely, reliable and easily accessible information in domains such as natural disaster planning and response, the environment, agriculture, land use, climate change and security. GMES is made up of an In-situ Component, a Services Component and a Space Component. ESA is responsible for coordinating the Space Component which is composed of dedicated satellite missions, called Sentinels, and so called Contributing Missions, owned and operated by national agencies or commercial entities of ESA/EU Member States, EUMETSAT or other third parties. It also comprises the associated Ground Segment infrastructure necessary to access, process and disseminate the data from the multitude of missions contributing to GMES. ESA is also responsible for the development and procurement of the dedicated Sentinel satellites. Lastly, ESA will act as interim operator for Sentinel missions -1, -2 and land part of Sentinel-3 while EUMETSAT will operate the ocean part of Sentinel-3 as well as the S-4/-5 instruments which are flying on-board EUMETSAT's MTG and post-EPS respectively. The Sentinels will be the first series of dedicated operational satellites to meet the Earth observation needs of GMES users concerning atmosphere, ocean and land monitoring as well as emergency response and security. The Sentinel-1 constellation is a pair of synthetic aperture radar (SAR) imaging satellites. It ensures continuity of C-band SAR data and builds upon heritage and experience with the ERS and Envisat satellites. Sentinel-1 satellites will provide almost 10 times the data obtained by Envisat's ASAR instrument. A pair of Sentinel-2 satellites will routinely provide high resolution (10-60 m) optical images globally with frequent revisits tailored to the needs of GMES land and emergency services. Sentinel-2 aims at ensuring continuity of SPOT and LANDSAT type data, with improvements to allow service evolution. A pair of Sentinel-3 satellites will provide global near real time ocean, ice and land monitoring. It continues observations of ERS, Envisat and SPOT/Vegetation. Sentinel 4 and 5 will be dedicated to monitor atmospheric trace gases from geostationary and low Earth orbit respectively. A Sentinel-5 precursor satellite will be launched at the end of 2014 to fill the gap until the arrival of Sentinel-5 on board post-EPS. The Contributing Missions are satellite missions operated by national agencies or commercial entities of Member States, EUMETSAT or other third parties, which do not replace nor duplicate the capacities of the dedicated Sentinel missions but rather complement them. The GMES data will feed the different services: Land, Marine, Atmosphere, Emergency and Security. Data from the former 3 services will also feed Climate Change applications. Some of these services will become fully operational in the next years. As part of the ESA led GMES Space Component, ESA and the EC are working together to define the principles and implementation scheme of the Sentinel Data Policy. The new data policy aims at providing free-of-charge access to all Sentinel data, both for public, commercial and scientific use. These "free and open" data policy principles have been approved by ESA Member States. EU approval is expected in the course of 2010.

Basic Radar Altimetry Toolbox: Tools to Use Radar Altimetry for Geodesy

NASA Astrophysics Data System (ADS)

Rosmorduc, V.; Benveniste, J. J.; Bronner, E.; Niejmeier, S.

2010-12-01

Radar altimetry is very much a technique expanding its applications and uses. If quite a lot of efforts have been made for oceanography users (including easy-to-use data), the use of those data for geodesy, especially combined witht ESA GOCE mission data is still somehow hard. ESA and CNES thus had the Basic Radar Altimetry Toolbox developed (as well as, on ESA side, the GOCE User Toolbox, both being linked). The Basic Radar Altimetry Toolbox is an "all-altimeter" collection of tools, tutorials and documents designed to facilitate the use of radar altimetry data. The software is able: - to read most distributed radar altimetry data, from ERS-1 & 2, Topex/Poseidon, Geosat Follow-on, Jason-1, Envisat, Jason- 2, CryoSat and the future Saral missions, - to perform some processing, data editing and statistic, - and to visualize the results. It can be used at several levels/several ways: - as a data reading tool, with APIs for C, Fortran, Matlab and IDL - as processing/extraction routines, through the on-line command mode - as an educational and a quick-look tool, with the graphical user interface As part of the Toolbox, a Radar Altimetry Tutorial gives general information about altimetry, the technique involved and its applications, as well as an overview of past, present and future missions, including information on how to access data and additional software and documentation. It also presents a series of data use cases, covering all uses of altimetry over ocean, cryosphere and land, showing the basic methods for some of the most frequent manners of using altimetry data. It is an opportunity to teach remote sensing with practical training. It has been available from April 2007, and had been demonstrated during training courses and scientific meetings. About 1200 people downloaded it (Summer 2010), with many "newcomers" to altimetry among them. Users' feedbacks, developments in altimetry, and practice, showed that new interesting features could be added. Some have been added and/or improved in version 2. Others are ongoing, some are in discussion. Examples and Data use cases on geodesy will be presented. BRAT is developed under contract with ESA and CNES.

Observing rotation and deformation of sea ice with synthetic aperture radar

NASA Technical Reports Server (NTRS)

Vesecky, J. F.; Samadani, R.; Daida, J. M.; Smith, M. P.; Bracewell, R. N.

1987-01-01

The ESA's ERS-1 satellite will carry SARs over the polar regions; an important component in the use of these data is an automated scheme for the extraction of sea ice velocity fields from a sequence of SAR images of the same geographical region. The image pyramid area-correlation hierarchical method is noted to be vulnerable to uncertainties for sea ice rotations greater than 10-15 deg between SAR observations. Rotation-invariant methods can successfully track isolated floes in the marginal ice zone. Hu's (1962) invariant moments are also worth considering as a possible basis for rotation-invariant tracking methods. Feature tracking is inherently robust for tracking rotating sea ice, but is limited when features are floe-lead boundaries. A variety of techniques appears neccessary.

Standard Information Models for Representing Adverse Sensitivity Information in Clinical Documents.

PubMed

Topaz, M; Seger, D L; Goss, F; Lai, K; Slight, S P; Lau, J J; Nandigam, H; Zhou, L

2016-01-01

Adverse sensitivity (e.g., allergy and intolerance) information is a critical component of any electronic health record system. While several standards exist for structured entry of adverse sensitivity information, many clinicians record this data as free text. This study aimed to 1) identify and compare the existing common adverse sensitivity information models, and 2) to evaluate the coverage of the adverse sensitivity information models for representing allergy information on a subset of inpatient and outpatient adverse sensitivity clinical notes. We compared four common adverse sensitivity information models: Health Level 7 Allergy and Intolerance Domain Analysis Model, HL7-DAM; the Fast Healthcare Interoperability Resources, FHIR; the Consolidated Continuity of Care Document, C-CDA; and OpenEHR, and evaluated their coverage on a corpus of inpatient and outpatient notes (n = 120). We found that allergy specialists' notes had the highest frequency of adverse sensitivity attributes per note, whereas emergency department notes had the fewest attributes. Overall, the models had many similarities in the central attributes which covered between 75% and 95% of adverse sensitivity information contained within the notes. However, representations of some attributes (especially the value-sets) were not well aligned between the models, which is likely to present an obstacle for achieving data interoperability. Also, adverse sensitivity exceptions were not well represented among the information models. Although we found that common adverse sensitivity models cover a significant portion of relevant information in the clinical notes, our results highlight areas needed to be reconciled between the standards for data interoperability.

78 FR 4127 - Proposed Information Collection; Comment Request; Basic Requirements for Special Exemption...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-18

..., Import, and Export Marine Mammals, Threatened and Endangered Species, and for Maintaining a Captive Marine Mammal Inventory Under the Marine Mammal Protection, the Fur Seal, and the Endangered Species Acts....C. 1151 et seq.; FSA), and Endangered Species Act (16 U.S.C. 1531 et seq.; ESA) prohibit certain...

77 FR 25733 - Receipt of Applications for Endangered Species Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-01

... Species Act (ESA) prohibits activities with listed species unless a Federal permit is issued that allows... 904/731-3191; facsimile 904/731-3045. SUPPLEMENTARY INFORMATION: The public is invited to comment on... is provided under section 10(c) of the Act. If you wish to comment, you may submit comments by any...

76 FR 61670 - Receipt of an Application for Incidental Take Permit (16230)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-05

... sensitive or protected information. NMFS will accept anonymous comments (enter ``N/A'' in the required... incidental to, and not the purpose of, otherwise lawful activities. Section 10(a)(1)(B) of the ESA provides... species are included in the conservation plan and Permit application: Loggerhead (Caretta caretta), green...

Probabilistic Tsunami Hazard Assessment along Nankai Trough (2) a comprehensive assessment including a variety of earthquake source areas other than those that the Earthquake Research Committee, Japanese government (2013) showed

NASA Astrophysics Data System (ADS)

Hirata, K.; Fujiwara, H.; Nakamura, H.; Osada, M.; Morikawa, N.; Kawai, S.; Ohsumi, T.; Aoi, S.; Yamamoto, N.; Matsuyama, H.; Toyama, N.; Kito, T.; Murashima, Y.; Murata, Y.; Inoue, T.; Saito, R.; Takayama, J.; Akiyama, S.; Korenaga, M.; Abe, Y.; Hashimoto, N.

2016-12-01

For the forthcoming Nankai earthquake with M8 to M9 class, the Earthquake Research Committee(ERC)/Headquarters for Earthquake Research Promotion, Japanese government (2013) showed 15 examples of earthquake source areas (ESAs) as possible combinations of 18 sub-regions (6 segments along trough and 3 segments normal to trough) and assessed the occurrence probability within the next 30 years (from Jan. 1, 2013) was 60% to 70%. Hirata et al.(2015, AGU) presented Probabilistic Tsunami Hazard Assessment (PTHA) along Nankai Trough in the case where diversity of the next event's ESA is modeled by only the 15 ESAs. In this study, we newly set 70 ESAs in addition of the previous 15 ESAs so that total of 85 ESAs are considered. By producing tens of faults models, with various slip distribution patterns, for each of 85 ESAs, we obtain 2500 fault models in addition of previous 1400 fault models so that total of 3900 fault models are considered to model the diversity of the next Nankai earthquake rupture (Toyama et al.,2015, JpGU). For PTHA, the occurrence probability of the next Nankai earthquake is distributed to possible 3900 fault models in the viewpoint of similarity to the 15 ESAs' extents (Abe et al.,2015, JpGU). A major concept of the occurrence probability distribution is; (i) earthquakes rupturing on any of 15 ESAs that ERC(2013) showed most likely occur, (ii) earthquakes rupturing on any of ESAs whose along-trench extent is the same as any of 15 ESAs but trough-normal extent differs from it second likely occur, (iii) earthquakes rupturing on any of ESAs whose both of along-trough and trough-normal extents differ from any of 15 ESAs rarely occur. Procedures for tsunami simulation and probabilistic tsunami hazard synthesis are the same as Hirata et al (2015). A tsunami hazard map, synthesized under an assumption that the Nankai earthquakes can be modeled as a renewal process based on BPT distribution with a mean recurrence interval of 88.2 years (ERC, 2013) and an aperiodicity of 0.22, as the median of the values (0.20 to 0.24)that ERC (2013) recommended, suggests that several coastal segments along the southwest coast of Shikoku Island, the southeast coast of Kii Peninsula, and the west coast of Izu Peninsula show over 26 % in exceedance probability that maximum water rise exceeds 10 meters at any coastal point within the next 30 years.

77 FR 73219 - Endangered and Threatened Wildlife and Plants: Proposed Listing Determinations for 82 Reef...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-07

...We, NMFS, have completed comprehensive status reviews under the Endangered Species Act (ESA) of 82 reef-building coral species in response to a petition submitted by the Center for Biological Diversity (CBD) to list the species as either threatened or endangered. We have determined, based on the best scientific and commercial data available and efforts being made to protect the species, that 12 of the petitioned coral species warrant listing as endangered (five Caribbean and seven Indo-Pacific), 54 coral species warrant listing as threatened (two Caribbean and 52 Indo-Pacific), and 16 coral species (all Indo- Pacific) do not warrant listing as threatened or endangered under the ESA. Additionally, we have determined, based on the best scientific and commercial information available and efforts undertaken to protect the species, two Caribbean coral species currently listed warrant reclassification from threatened to endangered. We are announcing that 18 public hearings will be held during the public comment period to provide additional opportunities and formats to receive public input. See SUPPLEMENTARY INFORMATION for public hearing dates, times, and locations.

Risks of Venous Thromboembolism, Stroke, Heart Disease, and Myelodysplastic Syndrome Associated With Hematopoietic Growth Factors in a Large Population-Based Cohort of Patients With Colorectal Cancer.

PubMed

Du, Xianglin L; Zhang, Yefei

2015-12-01

To determine the relationship between the receipt of colony-stimulating factors (CSFs) with erythropoiesis-stimulating agents (ESAs) and the risk of developing venous thromboembolism (VTE), stroke, heart disease, and myelodysplastic syndrome (MDS) in patients with colorectal cancer. We studied 80,925 patients diagnosed with colorectal cancer at age ≥ 65 years in 1992-2009 from the nationwide 16 areas of the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data. Cumulative incidence and the time to events Cox hazard regressions were used to explore the risks of outcomes in association with the receipt of CSFs and ESAs. Patients who received chemotherapy (CT) with both CSF and ESA were 58% more likely to develop VTE than those who received CT without CSF and ESA (hazard ratio, 1.58; 95% confidence interval, 1.43-1.76). The risk of stroke appeared to be not associated with the use of CSF and ESA, whereas the risk of heart disease was only significantly elevated in those patients who did not receive CT but received ESA. The risk of acute myeloid leukemia or MDS was significantly increased 4- to 9-fold in patients who received ESA, regardless of receipt of CT or CSF. The use of ESAs was significantly associated with a substantially increased risk of MDS in patients with colorectal cancer. The use of CSFs and ESAs was also significantly associated with a moderately increased risk of VTE and a slightly elevated risk of heart disease. Copyright © 2015 Elsevier Inc. All rights reserved.

Predictors of Hyporesponsiveness to Erythropoiesis-Stimulating Agents in Hemodialysis Patients

PubMed Central

Kalantar-Zadeh, Kamyar; Lee, Grace H; Miller, Jessica E.; Streja, Elani; Jing, Jennie; Robertson, John A; Kovesdy, Csaba P.

2009-01-01

Background Identification of predictors of hyporesponsiveness to erythropoietin-stimulating agents (ESA) in hemodialysis (HD) patients may help improve anemia management and reduce hemoglobin variability. Study Design We conducted repeated measure and logistic regression analyses in a retrospective cohort of long-term HD patients to examine the association of iron markers and measures of renal osteodystrophy with ESA-responsiveness. The ESA-response coefficient at the individual level, i.e., the least-confounded dose-response association, was separated from the population level, assumed to represent confounding by medical indication. Setting/Participants The national database of a large dialysis organization (DaVita) with 38,328 surviving prevalent HD patients over 12 months, who received ESA for at least 3 consecutive calendar quarters, was examined. Predictors Serum levels of ferritin, iron saturation ratio (ISAT), intact parathyroid hormone (PTH) and alkaline phosphatase levels. Outcomes/Other Measurements The main outcome was case-mix adjusted hemoglobin response to quarterly averaged ESA dose at individual level. The odds ratio (OR) of the greatest vs. poorest ESA-response quartile at patient level was calculated. OR<1.0 indicated ESA hyporesponsiveness and OR>1.0 enhanced responsiveness. Results The mean (±SD) ESA-response coefficients of the least to most responsive quartiles were 0.301±0.033, 0.344±0.004, 0.357±0.004, and 0.389±0.026 g/dL higher hemoglobin per 1,000 units/week higher ESA dose in each quarter, respectively. The ORs of the greatest vs. poorest ESA-responsiveness at patient level were the following: Serum ferritin<200 ng/ml: 0.77 [95% confidence interval: 0.70–0.86] (reference: 200–500 ng/ml), ISAT<20%: 0.54 [0.49–0.59] (reference: 20–30%), intact PTH≥600 pg/ml: 0.54 [0.49–0.60] (reference: 150–300 pg/ml), and alkaline phosphatase ≥160 IU/L: 0.64 [0.58–0.70] (reference: 80–120 IU/L). Lower estimated dietary protein intake and serum levels of nutritional markers were also associated with higher risk of ESA-hyporesponsiveness. Limitations Our results may incorporate uncontrolled confounding. Achieved hemoglobin may have different associations than targeted hemoglobin. Conclusions In long-term HD patients, low iron stores, hyperparathyroidism and high turnover bone disease are associated with significant ESA-hyporesponsiveness. Prospective studies are needed to verify these associations. PMID:19339087

Reflections of ions in electrostatic analyzers: a case study with New Horizons/Solar Wind Around Pluto.

PubMed

Randol, B M; Ebert, R W; Allegrini, F; McComas, D J; Schwadron, N A

2010-11-01

Electrostatic analyzers (ESAs), in various forms, are used to measure plasma in a range of applications. In this article, we describe how ions reflect from the interior surfaces of an ESA, the detection of which constitutes a fundamentally nonideal response of ESAs. We demonstrate this effect by comparing laboratory data from a real ESA-based space instrument, the Solar Wind Around Pluto (SWAP) instrument, aboard the NASA New Horizons spacecraft, to results from a model based on quantum mechanical simulations of particles reflected from the instrument's surfaces combined with simulations of particle trajectories through the instrument's applied electrostatic fields. Thus, we show, for the first time, how reflected ions in ESAs lead to nonideal effects that have important implications for understanding the data returned by these instruments, as well as for designing new low-background ESA-based instruments. Specifically, we show that the response of SWAP widens considerably below a level of 10(-3) of the peak response. Thus, a direct measurement of a plasma distribution with SWAP will have an energy-dependent background on the order of ≤10(-3) of the peak of the signal due to that distribution. We predict that this order of magnitude estimate for the background applies to a large number of ESA-based instruments because ESAs operate using a common principle. However, the exact shape of the energy-dependent response will be different for different instruments. The principle of operation is that ions outside the ideal range of energy-per-charge are deflected into the walls of the ESA. Therefore, we propose that a new design paradigm is necessary to mitigate the effect of ion reflections and thus accurately and directly measure the energy spectrum of a plasma using ESAs. In this article, we build a framework for minimizing the effect of ion reflections in the design of new ESAs. Through the use of existing computer simulation software, a design team can use our method to quantify the amount of reflections in their instrument and iteratively change design parameters before fabrication, conserving resources. A possible direction for the new design paradigm is having nonsolid walls of the ESA, already used in some applications.

Reflections of ions in electrostatic analyzers: A case study with New Horizons/Solar Wind Around Pluto

DOE Office of Scientific and Technical Information (OSTI.GOV)

Randol, B. M.; Ebert, R. W.; Space Science and Engineering Division, Southwest Research Institute, San Antonio, Texas 78228

Electrostatic analyzers (ESAs), in various forms, are used to measure plasma in a range of applications. In this article, we describe how ions reflect from the interior surfaces of an ESA, the detection of which constitutes a fundamentally nonideal response of ESAs. We demonstrate this effect by comparing laboratory data from a real ESA-based space instrument, the Solar Wind Around Pluto (SWAP) instrument, aboard the NASA New Horizons spacecraft, to results from a model based on quantum mechanical simulations of particles reflected from the instrument's surfaces combined with simulations of particle trajectories through the instrument's applied electrostatic fields. Thus, wemore » show, for the first time, how reflected ions in ESAs lead to nonideal effects that have important implications for understanding the data returned by these instruments, as well as for designing new low-background ESA-based instruments. Specifically, we show that the response of SWAP widens considerably below a level of 10{sup -3} of the peak response. Thus, a direct measurement of a plasma distribution with SWAP will have an energy-dependent background on the order of {<=}10{sup -3} of the peak of the signal due to that distribution. We predict that this order of magnitude estimate for the background applies to a large number of ESA-based instruments because ESAs operate using a common principle. However, the exact shape of the energy-dependent response will be different for different instruments. The principle of operation is that ions outside the ideal range of energy-per-charge are deflected into the walls of the ESA. Therefore, we propose that a new design paradigm is necessary to mitigate the effect of ion reflections and thus accurately and directly measure the energy spectrum of a plasma using ESAs. In this article, we build a framework for minimizing the effect of ion reflections in the design of new ESAs. Through the use of existing computer simulation software, a design team can use our method to quantify the amount of reflections in their instrument and iteratively change design parameters before fabrication, conserving resources. A possible direction for the new design paradigm is having nonsolid walls of the ESA, already used in some applications.« less

Budget impact analysis on erythropoiesis-stimulating agents use for the management of chemotherapy-induced anaemia in Greece.

PubMed

Nikolaidi, Eleftheria; Hatzikou, Magdalini; Geitona, Mary

2013-07-16

Chemotherapy-induced anaemia is a common and significant complication of chemotherapy treatment. Blood transfusion and administration of Erythropoiesis-Stimulating Agents (ESAs) either alone or in combination with iron are the most widely used therapeutic options. In Greece, ESAs are among the top ten therapeutic groups with the highest pharmaceutical expenditure, since they are fully reimbursed by social security funds. The objective of the study is to determine potential cost savings related with the use of biosimilar over originator ESAs for the management of the newly diagnosed chemotherapy-induced anemic patients. A budget impact analysis has been carried through the elaboration of national epidemiological, clinical and economic data. Epidemiological data derived from WHO (GLOBOCAN) and the European Cancer Anaemia Survey. Clinical data reflect oncology patients' disease management. ESAs consumption was based on data from the biggest social security fund (IKA). The administration of ESAs under different dosing schemes and time periods has been estimated by separating them in originators and biosimilars as well as by classifying anaemic patients in responders and non-responders. Cost analysis is based on newly diagnosed patients' alternative treatment scenarios. Treatment costs and prices are used in 2012 values. The Social Security Funds's perspective was undertaken. Based on the annual incidence rates, 2.551 newly diagnosed chemotherapy-induced anemic patients are expected to be treated with ESAs. Average cost of treatment on originators ESAs for responders is €2.887 for the 15-week ESAs treatment and €5.019 for non-responders, while on biosimilars €2.623 and €4.009 respectively. Treatment cost on biosimilars is 10.1% lower than originators for responders and 25.2% for non-responders. Budget impact estimates show that treating anemic patients with originator ESAs was estimated at €10.084.800 compared to €8.460.119 when biosimilar ESAs were used, leading to an overall 19,20% cost reduction favoring biosimilars. In Greece, the treatment on biosimilar ESAs seems to be a cost saving option over originators for the newly diagnosed chemotherapy-induced anemic patients, since it corresponds to 5% of the annual overall consumption and expands patients' access to ESAs treatment. Health care decision making should rely on evidence based treatments in order to achieve social funds' sustainability in an era of economic recession.

Stability and Repeatability of the Distress Thermometer (DT) and the Edmonton Symptom Assessment System-Revised (ESAS-r) with Parents of Childhood Cancer Survivors.

PubMed

Leclair, Tatsiana; Carret, Anne-Sophie; Samson, Yvan; Sultan, Serge

2016-01-01

Parents report psychological distress in association with their child's cancer. Reliable tools are needed to screen parental distress over the cancer trajectory. This study aimed to estimate the stability and repeatability of the Distress Thermometer (DT) and the Depression and Anxiety items of the Edmonton Symptom Assessment System-revised (ESAS-r-D; -A) in parents of children diagnosed with cancer. Fifty parents (28 mothers, median age = 44) of clinically stable survivors of childhood solid and brain tumours completed questionnaires about their own distress (DT, ESAS-r-D; -A, Brief Symptom Inventory-18: BSI-18, Patient Health Questionnaire-9: PHQ-9, Generalized Anxiety Disorder-7: GAD-7) and their children's quality of life (QoL; Peds Quality of Life: PedsQL) twice, with a month interval between the two assessments. At retest, parents also evaluated life events that occurred between the two time points. Hierarchical regressions explored moderators for the temporal stability of test measures. Stability estimates were ICC = .78 for the DT, .55 for the ESAS-r-D, and .47 for the ESAS-r-A. Caseness agreement between test and retest was substantial for the DT, fair for the ESAS-r-D, and slight for the ESAS-r-A. Repeatability analyses indicated that the error range for the DT was more than 2 pts below/above actual measurement, whereas it was more than 3 pts for the ESAS-r-A, and 2.5 for the ESAS-r-D. Instability of the DT could be explained by changes in children's physical QoL, but not by other components of QoL or life events. No moderators of stability could be identified for the ESAS-r items. The DT appears to be a fairly stable measure when the respondent's condition is stable yet with a relatively wide error range. Fluctuations in distress-related constructs may affect the temporal stability of the DT. The lower stability of ESAS-r items may result from shorter time-lapse instructions resulting in a greater sensitivity to change. Findings support future research on the DT as a reliable instrument in caregivers.

Stability and Repeatability of the Distress Thermometer (DT) and the Edmonton Symptom Assessment System-Revised (ESAS-r) with Parents of Childhood Cancer Survivors

PubMed Central

Carret, Anne-Sophie; Samson, Yvan; Sultan, Serge

2016-01-01

Objective Parents report psychological distress in association with their child's cancer. Reliable tools are needed to screen parental distress over the cancer trajectory. This study aimed to estimate the stability and repeatability of the Distress Thermometer (DT) and the Depression and Anxiety items of the Edmonton Symptom Assessment System-revised (ESAS-r-D; -A) in parents of children diagnosed with cancer. Methods Fifty parents (28 mothers, median age = 44) of clinically stable survivors of childhood solid and brain tumours completed questionnaires about their own distress (DT, ESAS-r-D; -A, Brief Symptom Inventory-18: BSI-18, Patient Health Questionnaire-9: PHQ-9, Generalized Anxiety Disorder-7: GAD-7) and their children’s quality of life (QoL; Peds Quality of Life: PedsQL) twice, with a month interval between the two assessments. At retest, parents also evaluated life events that occurred between the two time points. Hierarchical regressions explored moderators for the temporal stability of test measures. Results Stability estimates were ICC = .78 for the DT, .55 for the ESAS-r-D, and .47 for the ESAS-r-A. Caseness agreement between test and retest was substantial for the DT, fair for the ESAS-r-D, and slight for the ESAS-r-A. Repeatability analyses indicated that the error range for the DT was more than 2 pts below/above actual measurement, whereas it was more than 3 pts for the ESAS-r-A, and 2.5 for the ESAS-r-D. Instability of the DT could be explained by changes in children’s physical QoL, but not by other components of QoL or life events. No moderators of stability could be identified for the ESAS-r items. Conclusions The DT appears to be a fairly stable measure when the respondent's condition is stable yet with a relatively wide error range. Fluctuations in distress-related constructs may affect the temporal stability of the DT. The lower stability of ESAS-r items may result from shorter time-lapse instructions resulting in a greater sensitivity to change. Findings support future research on the DT as a reliable instrument in caregivers. PMID:27454432

Sentinel-2 Mission status

NASA Astrophysics Data System (ADS)

Hoersch, Bianca; Colin, Olivier; Gascon, Ferran; Arino, Olivier; Spoto, Francois; Marchese, Franco; Krassenburg, Mike; Koetz, Benjamin

2016-04-01

Copernicus is a joint initiative of the European Commission (EC) and the European Space Agency (ESA), designed to establish a European capacity for the provision and use of operational monitoring information for environment and security applications. Within the Copernicus programme, ESA is responsible for the development of the Space Component, a fully operational space-based capability to supply earth-observation data to sustain environmental information Services in Europe. The Sentinel missions are Copernicus dedicated Earth Observation missions composing the essential elements of the Space Component. In the global Copernicus framework, they are complemented by other satellites made available by third-parties or by ESA and coordinated in the synergistic system through the Copernicus Data-Access system versus the Copernicus Services. The Copernicus Sentinel-2 mission provides continuity to services relying on multi-spectral high-resolution optical observations over global terrestrial surfaces. Sentinel-2 capitalizes on the technology and the vast experience acquired in Europe and the US to sustain the operational supply of data for services such as forest monitoring, land cover changes detection or natural disasters management. The Sentinel-2 mission offers an unprecedented combination of the following capabilities: ○ Systematic global coverage of land surfaces: from 56°South to 84°North, coastal waters and Mediterranean sea; ○ High revisit: every 5 days at equator under the same viewing conditions with 2 satellites; ○ High spatial resolution: 10m, 20m and 60m; ○ Multi-spectral information with 13 bands in the visible, near infra-red and short wave infra-red part of the spectrum; ○ Wide field of view: 290 km. The data from the Sentinel-2 mission are available openly and freely for all users with online easy access since December 2015. The presentation will give a status report on the Sentinel-2 mission, and outlook for the remaining ramp-up Phase, the completion of the constellation and a view to ongoing evolutions, together with a view on data exploitation.

"Physics on Stage" Festival Video Now Available

NASA Astrophysics Data System (ADS)

2001-01-01

ESO Video Clip 01/01 is issued on the web in conjunction with the release of an 18-min documentary video from the Science Festival of the "Physics On Stage" programme. This unique event took place during November 6-11, 2000, on the CERN premises at the French-Swiss border near Geneva, and formed part of the European Science and Technology Week 2000, an initiative by the European Commission to raise the public awareness of science in Europe. Physics On Stage and the Science Festival were jointly organised by CERN, ESA and ESO, in collaboration with the European Physical Society (EPS) and the European Association for Astronomy Education (EAAE) and national organisations in about 25 European countries. During this final phase of the yearlong Physics On Stage programme, more than 500 physics teachers, government officials and media representatives gathered at CERN to discuss different aspects of physics education. The meeting was particular timely in view of the current decline of interest in physics and technology by Europe's citizens, especially schoolchildren. It included spectacular demonstrations of new educational materials and methods. An 18-min video is now available that documents this event. It conveys the great enthusiasm of the many participants who spent an extremely fruitful week, meeting and exchanging information with colleagues from all over the continent. It shows the various types of activities that took place, from the central "fair" with national and organisational booths to the exciting performances and other dramatic presentations. Based of the outcome of 13 workshops that focussed on different subject matters, a series of very useful recommendations was passed at the final session. The Science Festival was also visited by several high-ranking officials, including the European Commissioner for Research, Phillipe Busquin. Full reports from the Festival will soon become available from the International Steering Committee..More information is available on the "Physics on Stage" webpages at CERN , ESA and ESO ). Note also the brief account published in the December 2000 issue of the ESO Messenger. The present video clip is available in four versions: two MPEG files and two streamer-versions of different sizes; the latter require RealPlayer software. Video Clip 01/01 may be freely reproduced. Tapes of this video clip and the 18-min video, suitable for transmission and in full professional quality (Betacam, etc.), are available for broadcasters upon request ; please contact the ESO EPR Department for more details. Most of the ESO PR Video Clips at the ESO website provide "animated" illustrations of the ongoing work and events at the European Southern Observatory. The most recent clip was: ESO PR Video Clip 06/00 about Fourth Light at Paranal! (4 September 2000) . General information is available on the web about ESO videos.

Rasch analysis of the Edmonton Symptom Assessment System and research implications

PubMed Central

Cheifetz, O.; Packham, T.L.; MacDermid, J.C.

2014-01-01

Background Reliable and valid assessment of the disease burden across all forms of cancer is critical to the evaluation of treatment effectiveness and patient progress. The Edmonton Symptom Assessment System (esas) is used for routine evaluation of people attending for cancer care. In the present study, we used Rasch analysis to explore the measurement properties of the esas and to determine the effect of using Rasch-proposed interval-level esas scoring compared with traditional scoring when evaluating the effects of an exercise program for cancer survivors. Methods Polytomous Rasch analysis (Andrich’s rating-scale model) was applied to data from 26,645 esas questionnaires completed at the Juravinski Cancer Centre. The fit of the esas to the polytomous Rasch model was investigated, including evaluations of differential item functioning for sex, age, and disease group. The research implication was investigated by comparing the results of an observational research study previously analysed using a traditional approach with the results obtained by Rasch-proposed interval-level esas scoring. Results The Rasch reliability index was 0.73, falling short of the desired 0.80–0.90 level. However, the esas was found to fit the Rasch model, including the criteria for uni-dimensional data. The analysis suggests that the current esas scoring system of 0–10 could be collapsed to a 6-point scale. Use of the Rasch-proposed interval-level scoring yielded results that were different from those calculated using summarized ordinal-level esas scores. Differential item functioning was not found for sex, age, or diagnosis groups. Conclusions The esas is a moderately reliable uni-dimensional measure of cancer disease burden and can provide interval-level scaling with Rasch-based scoring. Further, our study indicates that, compared with the traditional scoring metric, Rasch-based scoring could result in substantive changes to conclusions. PMID:24764703

Development of Onboard Computer Complex for Russian Segment of ISS

NASA Technical Reports Server (NTRS)

Branets, V.; Brand, G.; Vlasov, R.; Graf, I.; Clubb, J.; Mikrin, E.; Samitov, R.

1998-01-01

Report present a description of the Onboard Computer Complex (CC) that was developed during the period of 1994-1998 for the Russian Segment of ISS. The system was developed in co-operation with NASA and ESA. ESA developed a new computation system under the RSC Energia Technical Assignment, called DMS-R. The CC also includes elements developed by Russian experts and organizations. A general architecture of the computer system and the characteristics of primary elements of this system are described. The system was integrated at RSC Energia with the participation of American and European specialists. The report contains information on software simulators, verification and de-bugging facilities witch were been developed for both stand-alone and integrated tests and verification. This CC serves as the basis for the Russian Segment Onboard Control Complex on ISS.

Product Quality of ESA's Atmospheric-Chemistry Missions

NASA Astrophysics Data System (ADS)

Dehn, Angelika; Bojkov, Bojan; Fehr, Thorsten

2012-11-01

ESA's Atmospheric Chemistry Mission is providing fundamental information for the understanding of atmospheric chemistry processes. The global datasets are supporting climate research, air quality assessments, stratospheric ozone monitoring and many other science areas and operational services.ENVISAT with GOMOS, MIPAS and SCIAMACHY has contributed to a unique data set over a period of 10 years, before its major anomaly in April 2012, leading to the end of the operational part of the mission. GOME, on board ERS-2 has been acquiring data for 16 years, before it's de-commissioning in July 2011.The quality of the corresponding data sets is continuously being improved, also beyond the termination of the satellite's operational phases. This is realised with the support of numerous teams of science experts, evolving the algorithm and calibration baseline and validation teams assessing the resulting upgraded data sets.

Anaesthesiologists' views on the need for point-of-care information system in the operating room: a survey of the European Society of Anaesthesiologists.

PubMed

Perel, A; Berkenstadt, H; Ziv, A; Katzenelson, R; Aitkenhead, A

2004-11-01

In this preliminary study we wanted to explore the attitudes of anaesthesiologists to a point-of-care information system in the operating room. The study was conducted as a preliminary step in the process of developing such a system by the European Society of Anaesthesiologists (ESA). A questionnaire was distributed to all 2240 attendees of the ESA's annual meeting in Gothenburg, Sweden, which took place in April 2001. Of the 329 responders (response rate of 14.6%), 79% were qualified specialists with more than 10 yr of experience (68%), mostly from Western Europe. Most responders admitted to regularly experiencing lack of medical knowledge relating to real-time patient care at least once a month (74%) or at least once a week (46%), and 39% admitted to having made errors during anaesthesia due to lack of medical information that can be otherwise found in a handbook. The choice ofa less optimal but more familiar approach to patient management due to lack of knowledge was reported by 37%. Eighty-eight percent of responders believe that having a point-of-care information system for the anaesthesiologists in the operating room is either important or very important. This preliminary survey demonstrates that lack of knowledge of anaesthesiologists may be a significant source of medical errors in the operating room, and suggests that a point-of-care information system for the anaesthesiologist may be of value.

A simple, sufficient, and consistent method to score the status of threats and demography of imperiled species

PubMed Central

Webber, Whitney M.; Li, Ya-Wei

2016-01-01

Managers of large, complex wildlife conservation programs need information on the conservation status of each of many species to help strategically allocate limited resources. Oversimplifying status data, however, runs the risk of missing information essential to strategic allocation. Conservation status consists of two components, the status of threats a species faces and the species’ demographic status. Neither component alone is sufficient to characterize conservation status. Here we present a simple key for scoring threat and demographic changes for species using detailed information provided in free-form textual descriptions of conservation status. This key is easy to use (simple), captures the two components of conservation status without the cost of more detailed measures (sufficient), and can be applied by different personnel to any taxon (consistent). To evaluate the key’s utility, we performed two analyses. First, we scored the threat and demographic status of 37 species recently recommended for reclassification under the Endangered Species Act (ESA) and 15 control species, then compared our scores to two metrics used for decision-making and reports to Congress. Second, we scored the threat and demographic status of all non-plant ESA-listed species from Florida (54 spp.), and evaluated scoring repeatability for a subset of those. While the metrics reported by the U.S. Fish and Wildlife Service (FWS) are often consistent with our scores in the first analysis, the results highlight two problems with the oversimplified metrics. First, we show that both metrics can mask underlying demographic declines or threat increases; for example, ∼40% of species not recommended for reclassification had changes in threats or demography. Second, we show that neither metric is consistent with either threats or demography alone, but conflates the two. The second analysis illustrates how the scoring key can be applied to a substantial set of species to understand overall patterns of ESA implementation. The scoring repeatability analysis shows promise, but indicates thorough training will be needed to ensure consistency. We propose that large conservation programs adopt our simple scoring system for threats and demography. By doing so, program administrators will have better information to monitor program effectiveness and guide their decisions. PMID:27478713

A simple, sufficient, and consistent method to score the status of threats and demography of imperiled species.

PubMed

Malcom, Jacob W; Webber, Whitney M; Li, Ya-Wei

2016-01-01

Managers of large, complex wildlife conservation programs need information on the conservation status of each of many species to help strategically allocate limited resources. Oversimplifying status data, however, runs the risk of missing information essential to strategic allocation. Conservation status consists of two components, the status of threats a species faces and the species' demographic status. Neither component alone is sufficient to characterize conservation status. Here we present a simple key for scoring threat and demographic changes for species using detailed information provided in free-form textual descriptions of conservation status. This key is easy to use (simple), captures the two components of conservation status without the cost of more detailed measures (sufficient), and can be applied by different personnel to any taxon (consistent). To evaluate the key's utility, we performed two analyses. First, we scored the threat and demographic status of 37 species recently recommended for reclassification under the Endangered Species Act (ESA) and 15 control species, then compared our scores to two metrics used for decision-making and reports to Congress. Second, we scored the threat and demographic status of all non-plant ESA-listed species from Florida (54 spp.), and evaluated scoring repeatability for a subset of those. While the metrics reported by the U.S. Fish and Wildlife Service (FWS) are often consistent with our scores in the first analysis, the results highlight two problems with the oversimplified metrics. First, we show that both metrics can mask underlying demographic declines or threat increases; for example, ∼40% of species not recommended for reclassification had changes in threats or demography. Second, we show that neither metric is consistent with either threats or demography alone, but conflates the two. The second analysis illustrates how the scoring key can be applied to a substantial set of species to understand overall patterns of ESA implementation. The scoring repeatability analysis shows promise, but indicates thorough training will be needed to ensure consistency. We propose that large conservation programs adopt our simple scoring system for threats and demography. By doing so, program administrators will have better information to monitor program effectiveness and guide their decisions.

Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update.

PubMed

Rizzo, J Douglas; Somerfield, Mark R; Hagerty, Karen L; Seidenfeld, Jerome; Bohlius, Julia; Bennett, Charles L; Cella, David F; Djulbegovic, Benjamin; Goode, Matthew J; Jakubowski, Ann A; Rarick, Mark U; Regan, David H; Lichtin, Alan E

2008-01-01

To update the American Society of Clinical Oncology/American Society of Hematology (ASCO/ASH) recommendations for the use of epoetin. The guideline was expanded to address use of darbepoetin and thromboembolic risk associated with these agents. An Update Committee ("Committee") reviewed and analyzed data published since 2002 through July 2007. MEDLINE and the Cochrane Collaboration Library databases were searched. For patients with chemotherapy-associated anemia, the Committee continues to recommend initiating an erythropoiesis-stimulating agent (ESA) as hemoglobin (Hb) approaches, or falls below, 10 g/dL, to increase Hb and decrease transfusions. ESA treatment continues to be recommended for patients with low-risk myelodysplasia for similar reasons. There is no evidence showing increased survival as a result of ESA treatment. Conclusive evidence is lacking that, absent clinical circumstances necessitating earlier treatment, initiating ESAs at Hb levels greater than 10 g/dL either spares more patients from transfusion or substantially improves their quality of life. Starting doses and dose modifications based on response or lack thereof should follow the package insert. Continuing ESAs beyond 6 to 8 weeks in the absence of response, assuming appropriate dose increase has been attempted in nonresponders as per US Food and Drug Administration-approved labeling, does not seem to be beneficial, and ESA therapy should be discontinued. The Committee recommends monitoring iron stores and supplementing iron intake for ESA-treated patients. ESAs should be used cautiously with chemotherapy, or in clinical states, associated with elevated risk for thromboembolic complications. The Committee also cautions against ESA use for patients with cancer who are not receiving chemotherapy, since recent trials report increased thromboembolic risks and decreased survival under these circumstances.

Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Hematology/American Society of Clinical Oncology clinical practice guideline update.

PubMed

Rizzo, J Douglas; Somerfield, Mark R; Hagerty, Karen L; Seidenfeld, Jerome; Bohlius, Julia; Bennett, Charles L; Cella, David F; Djulbegovic, Benjamin; Goode, Matthew J; Jakubowski, Ann A; Rarick, Mark U; Regan, David H; Lichtin, Alan E

2008-01-01

To update the American Society of Clinical Oncology/American Society of Hematology (ASCO/ASH) recommendations for the use of epoetin. The guideline was expanded to address use of darbepoetin and thromboembolic risk associated with these agents. An Update Committee ("Committee") reviewed and analyzed data published since 2002 through July 2007. MEDLINE and the Cochrane Collaboration Library databases were searched. For patients with chemotherapy-associated anemia, the Committee continues to recommend initiating an erythropoiesis-stimulating agent (ESA) as hemoglobin (Hb) approaches, or falls below, 10 g/dL, to increase Hb and decrease transfusions. ESA treatment continues to be recommended for patients with low-risk myelodysplasia for similar reasons. There is no evidence showing increased survival as a result of ESA treatment. Conclusive evidence is lacking that, absent clinical circumstances necessitating earlier treatment, initiating ESAs at Hb levels greater than 10 g/dL either spares more patients from transfusion or substantially improves their quality of life. Starting doses and dose modifications based on response or lack thereof should follow the package insert. Continuing ESAs beyond 6 to 8 weeks in the absence of response, assuming appropriate dose increase has been attempted in nonresponders as per US Food and Drug Administration-approved label, does not seem to be beneficial, and ESA therapy should be discontinued. The Committee recommends monitoring iron stores and supplementing iron intake for ESA-treated patients. ESAs should be used cautiously with chemotherapy, or in clinical states, associated with elevated risk for thromo-embolic complications. The Committee also cautions against ESA use for patients with cancer who are not receiving chemotherapy, since recent trials report increased thromboembolic risks and decreased survival under these circumstances.

[Gone with the wind or... Fate of scientific articles presented at large anesthesia congresses--an update].

PubMed

Meininger, D; Bück, M; Bohlmann, S; Weber, C F; Strouhal, U; Ihlow, K; Zacharowski, K; Byhahn, C

2011-02-01

The goal of the present study was to evaluate the publication rate of abstracts presented during the German Anesthesia Congress (Deutscher Anästhesiecongress, DAC) and the meeting of the European Society of Anesthesiologists (ESA) in the years 2000 and 2005 in Medline listed journals (http://www.ncbi.nlm.nih.gov/pubmed). In addition, the respective impact factors of the journals in which the articles were published were evaluated (http://www.isiknowledge.com). All abstracts of free papers and posters presented at the DAC and ESA from the years 2000 and 2005 were included into the study. The presence of authors and the topics of abstracts in the literature were analyzed by a Medline based inquiry over a time period of 5 years. The search was based on the last name and initials of authors and when these could not be identified in Medline the search was extended by keywords of relevant topics of the abstract. Umlauts "ä/ö/ü" were replaced by "ae/oe/ue" and "ß" was replaced by "ss". Only original papers were included in this analysis. Once an original paper was found the impact factor of the journal in that year was identified. A total of 465 abstracts from the DAC 2000, 378 abstracts from the DAC 2005, 644 abstracts from the ESA 2000 and 720 abstracts from the ESA 2005 were included. Of the abstracts from the DAC 2000, 183 (39%) were published in Medline listed journals, 179 (47%) from DAC 2005, 218 (34%) from ESA 2000 and 233 (32%) from ESA 2005. The ESA abstracts were published in English more often than the DAC abstracts (ESA 2000: 95%; ESA 2005: 95%; DAC 2000: 78%; DAC 2005: 86%). While the publication rate after the ESA remained nearly unchanged between 2000 and 2005, the publication rate after the DAC increased by about 7%. The average impact factors of the publications were 1.777 (DAC 2000), 2.836 (DAC 2005), 1.825 (ESA 2000) and 2.36 (ESA 2005). Independent of the congress (DAC or ESA) where the abstract was presented, most articles were published in the journal Anesthesia & Analgesia. In the year 2005 more abstracts of the DAC were published in Medline listed papers than in 2000. When comparing the number of abstracts published in Medline listed journals, more abstracts of the DAC were published compared to abstracts of the ESA. The increase in papers written in English after abstract presentation on the DAC is mostly due to the wider readership which can be reached with manuscripts in the English language. Besides a larger readership, English journals often also have a higher ranked impact factor. This analysis does not claim to be a complete registration of all published abstracts due to the limitation on Medline listed journals and publications in other journals were not rated. Medline was selected because of the widespread and international use of this database.

Longitudinal Analysis of New Information Types in Clinical Notes

PubMed Central

Zhang, Rui; Pakhomov, Serguei; Melton, Genevieve B.

2014-01-01

It is increasingly recognized that redundant information in clinical notes within electronic health record (EHR) systems is ubiquitous, significant, and may negatively impact the secondary use of these notes for research and patient care. We investigated several automated methods to identify redundant versus relevant new information in clinical reports. These methods may provide a valuable approach to extract clinically pertinent information and further improve the accuracy of clinical information extraction systems. In this study, we used UMLS semantic types to extract several types of new information, including problems, medications, and laboratory information. Automatically identified new information highly correlated with manual reference standard annotations. Methods to identify different types of new information can potentially help to build up more robust information extraction systems for clinical researchers as well as aid clinicians and researchers in navigating clinical notes more effectively and quickly identify information pertaining to changes in health states. PMID:25717418

NASA and ESA Collaboration on Hexavalent Chrome Alternatives Pretreatments Only Interim Test Report

NASA Technical Reports Server (NTRS)

Kessel, Kurt R.

2015-01-01

NASA and ESA continue to search for an alternative to hexavalent chromium in coatings applications that meet their performance requirements in corrosion protection, cost, operability, and health and safety, while typically specifying that performance must be equal to or greater than existing systems. The overall objective of the collaborative effort between NASA TEERM and ESA is to test and evaluate coating systems (pretreatments, pretreatments with primer, and pretreatments with primer and topcoat) as replacements for hexavalent chrome coatings in aerospace applications. This objective will be accomplished by testing promising coatings identified from previous NASA, ESA, Department of Defense (DOD), and other project experience. Additionally, several new materials will be analyzed according to ESA-identified specifications.

Aiding eco-labelling process and its implementation: Environmental Impact Assessment Methodology to define Product Category Rules for canned anchovies.

PubMed

Laso, Jara; Margallo, María; Fullana, Pére; Bala, Alba; Gazulla, Cristina; Irabien, Ángel; Aldaco, Rubén

2017-01-01

To be able to fulfil high market expectations for a number of practical applications, Environmental Product Declarations (EPDs) have to meet and comply with specific and strict methodological prerequisites. These expectations include the possibility to add up Life Cycle Assessment (LCA)-based information in the supply chain and to compare different EPDs. To achieve this goal, common and harmonized calculation rules have to be established, the so-called Product Category Rules (PCRs), which set the overall LCA calculation rules to create EPDs. This document provides PCRs for the assessment of the environmental performance of canned anchovies in Cantabria Region based on an Environmental Sustainability Assessment (ESA) method. This method uses two main variables: the natural resources sustainability (NRS) and the environmental burdens sustainability (EBS). To reduce the complexity of ESA and facilitate the decision-making process, all variables are normalized and weighted to obtain two global dimensionless indexes: resource consumption (X 1 ) and environmental burdens (X 2 ). •This paper sets the PCRs adapted to the Cantabrian canned anchovies.•ESA method facilitates the product comparison and the decision-making process.•This paper stablishes all the steps that an EPD should include within the PCRs of Cantabrian canned anchovies.

BepiColombo MMO status update

NASA Astrophysics Data System (ADS)

Hayakawa, Hajime; Maejima, Hironori

2013-04-01

BepiColombo is a ESA-JAXA joint mission to Mercury with the aim to understand the process of planetary formation and evolution as well as to understand similarities and differences between the magnetospheres of Mercury and Earth. The baseline mission consists of two spacecraft, i.e. the Mercury Planetary Orbiter (MPO) and the Mercury Magnetospheric Orbiter (MMO). The two orbiters will be launched in 2015 by an Ariane-5 and arrive at Mercury in 2022. JAXA is responsible for the development and operation of MMO, while ESA is responsible for the development and operation of MPO as well as the launch, transport, and the insertion of two spacecraft into their dedicated orbits. The main objectives of MMO are to study Mercury's magnetic field and plasma environment around Mercury. MMO is designed as a spin-stabilized spacecraft to be placed in a 400 km x 12,000 km polar orbit. The spacecraft will accommodate instruments mostly dedicated to the study of the magnetic field, waves, and particles near Mercury. MMO Mechanical Test Model (MMO-MTM) was transported to ESA/ESTEC and stack level (MCS: Mercury Cruise System) mechanical environmental test was finished last September. MMO EM electrical model was transported to Astrium Friedrichshafen and electrical interface test was performed on Octorber. MMO stand alone Flight Model (FM) AIV was started from last October and continues until early next year. After standalone AIV, MMO will be trasported to ESA/ESTEC to attend stack level final AIV. 10th BepiColombo science working team (SWT) meeting, which discusses BepiColombo science related matters, will be held on Sep. 2013 at Lapland. In this paper, we will report the latest information of MMO project status.

Sanitation marketing: A systematic review and theoretical critique using the capability approach.

PubMed

Barrington, D J; Sridharan, S; Shields, K F; Saunders, S G; Souter, R T; Bartram, J

2017-12-01

Sanitation is a human right that benefits health. As such, technical and behavioural interventions are widely implemented to increase the number of people using sanitation facilities. These include sanitation marketing interventions (SMIs), in which external support agencies (ESAs) use a hybrid of commercial and social marketing tools to increase supply of, and demand for, sanitation products and services. However, there is little critical discourse on SMIs, or independent rigorous analysis on whether they increase or reduce well-being. Most available information is from ESAs about their own SMI implementation. We systematically reviewed the grey and peer-reviewed literature on sanitation marketing, including qualitatively analysing and calculating descriptive statistics for the parameters measured, or intended to be measured, in publications reporting on 33 SMIs. Guided by the capability approach to development we identified that publications for most SMIs (n = 31, 94%) reported on commodities, whilst fewer reported on parameters related to impacts on well-being (i.e., functionings, n = 22, 67%, and capabilities, n = 20, 61%). When evaluating future SMIs, it may be useful to develop a list of contextualised well-being indicators for the particular SMI's location, taking into account local cultural norms, with this list ideally co-produced with local stakeholders. We identified two common practices in SMIs that can reduce well-being and widen well-being inequalities; namely, the promotion of conspicuous consumption and assaults on dignity, and we discuss the mechanisms by which such impacts occur. We recommend that ESAs understand sanitation marketing's potential to reduce well-being and design SMIs to minimize such detrimental impacts. Throughout the implementation phase ESAs should continuously monitor for well-being impacts and adapt practices to optimise well-being outcomes for all involved. Copyright © 2017. Published by Elsevier Ltd.

BASINS Technical Notes

EPA Pesticide Factsheets

EPA has developed several technical notes that provide in depth information on a specific function in BASINS. Technical notes can be used to answer questions users may have, or to provide additional information on the application of features in BASINS.

ESA presents INTEGRAL, its space observatory for Gamma-ray astronomy

NASA Astrophysics Data System (ADS)

1998-09-01

A unique opportunity for journalists and cameramen to view INTEGRAL will be provided at ESA/ESTEC, Noordwijk, the Netherlands on Tuesday 22 September. On show will be the full-size structural thermal model which is now beeing examined in ESA's test centre. Following introductions to the project, the INTEGRAL spacecraft can be seen, filmed and photographed in its special clean room environment.. Media representatives wishing to participate in the visit to ESA's test centre and the presentation of INTEGRAL are kindly requested to return by fax the attached registration form to ESA Public relations, Tel. +33 (0) 1.53.69.71.55 - Fax. +33 (0) 1.53.69.76.90. For details please see the attached programme Gamma-ray astronomy - why ? Gamma-rays cannot be detected from the ground since the earth's atmosphere shields us from high energetic radiation. Only space technology has made gamma-astronomy possible. To avoid background radiation effects INTEGRAL will spend most of its time in the orbit outside earth's radiation belts above an altitude of 40'000 km. Gamma-rays are the highest energy form of electromagnetic radiation. Therefore gamma-ray astronomy explores the most energetic phenomena occurring in nature and addresses some of the most fundamental problems in physics. We know for instance that most of the chemical elements in our bodies come from long-dead stars. But how were these elements formed? INTEGRAL will register gamma-ray evidence of element-making. Gamma-rays also appear when matter squirms in the intense gravity of collapsed stars or black holes. One of the most important scientific objectives of INTEGRAL is to study such compact objects as neutron stars or black holes. Besides stellar black holes there may exist much bigger specimens of these extremely dense objects. Most astronomers believe that in the heart of our Milky Way as in the centre of other galaxies there may lurk giant black holes. INTEGRAL will have to find evidence of these exotic objects. Even more strange than the energetic radiation coming from the centre of distant galaxies are flashes of extremely powerful radiation that suddenly appear somewhere on the gamma-sky and disappear again after a short time. These gamma-bursts seem to be the biggest observed explosions in the Universe. But nobody knows their source. Integral will help to solve this long-standing mystery. ESA, the pioneer in gamma-ray astronomy The satellite as it can now be seen at ESA's test centre is five meters high and weighs more than four tonnes. Two main instruments observe the gamma-rays. An imager will give the sharpest gamma-ray images. It is provided by a consortium led by an Italian scientist. Gamma-rays ignore lenses and mirror, so INTEGRAL makes its images with so-called coded-masks. A coded-mask telescope is basically a pinhole camera, but with a larger aperture, i.e. many pinholes. A spectrometer will gauge gamma-ray energies extremely precisely. It is developed by a team of scientists under joint French-German leadership and will be a 100 times more sensitive than the previous high spectral resolution space instrument. It is made of a high-purity Germanium detector that has to be cooled down to minus 188 degree Celsius. These two gamma-ray-instruments are supported by two monitor instruments that play a crucial role in the detection and identification of the gamma-ray sources. An X-ray monitor developed in Denmark will observe X-rays, still powerful but less energetic than gamma-rays. An optical telescope provided by Spain will observe the visible light emitted by the energetic objects. Switzerland will host the Integral Science Data Centre which will preprocess and distribute the scientific data. The mission is conceived as an observatory led by ESA with Russia contributing the launcher and NASA providing tracking support with its Deep Space Network. Alenia Aerospazio in Turin, Italy is ESA's prime contractor for building INTEGRAL. Launch by a Russian Proton rocket from Baikonur is actually scheduled for 2001. ESA pioneered gamma-ray astronomy in space with its COS-B satellite (1975). Russia's Granat (1989) and NASA's Compton GRO (1991) followed. But INTEGRAL will be better still. With this mission ESA will further strengthen its lead in gamma-astronomy. Principal Investigators : Imager : Pietro Ubertini (IAS, Frascati, Italy) Spectrometer : Gilbert Vedrenne (CESR, Toulouse/France) Volker Schoenfelder (MPE, Garching/.Germany) X-Ray monitor : Niels Lund (DSRI, Copenhagen/Denmark) Optical Monitoring Camera : Alvaro Gimenez (INTA, Madrid/Spain) Integral Science Data Center : Thierry Courvoisier (Genova Observatory, Switzerland) For further information, please contact : ESA Public Relations Division Tel: +33(0)1.53.69.71.55 Fax: +33(0)1.53.69.76.90 INTEGRAL MEDIA DAY Tuesday 22 September 1998 Newton Conference Centre ESTEC, Noordwijk, Keplerlaan 1 (The Netherlands) Programme 10:30 . Arrival and Registration in the Newton Conference Centre 10:45. Welcome and introduction by David Dale, Director of ESTEC 10:50 The Scientific Challenge : the mission of INTEGRAL, by Chistoph Winkler, INTEGRAL Project Scientist 11:10 The Technical Challenge : the INTEGRAL spacecraft, by Kai Clausen, INTEGRAL Project Manager 11:30 The Industrial Challenge by A. Simeone, Programme Director at Aleniaspazio 11:45 Question/Answer session 12:00 Visit to INTEGRAL spacecraft ; photo and film opportunities, incl. Interview opportunities with speakers 13:00 Informal buffet lunch in Foyer of Conference Centre Newton 14:30 End of event

Building Transatlantic Partnerships in Space Exploration The MPCV-SM Study

NASA Technical Reports Server (NTRS)

Wilde Detlef; Schubert, Kathy; Grantier, Julie; Deloo, Philippe; Price, Larry; Fenoglio, Franco; Chavy, Siegfrid

2012-01-01

Following the approval of the ESA ISS Exploitation Declaration for the ISS lifetime at the ESA Council Meeting in March 2011, ESA decided to partially offset the European obligations deriving from the extension of the ISS Programme until end 2020 with different means than ATVs, following the ATV-5 mission foreseen in mid 2014. The envisioned approach is based on a barter element(s) that would generate cost avoidance on the NASA side. NASA and ESA considered a number of Barter options, and concluded that the provision by ESA of the Service Module for the NASA Multi-Purpose Crew Vehicle (MPCV) was the barter with the most interest. A joint ESA - NASA working group was established to assess the feasibility of Europe developing this Module based on ATV heritage. The working group was supported by European and US industry namely Astrium, TAS-I and Lockheed-Martin. This paper gives an overview of the results of the on-going study as well as its perspective utilisation for the global space exploration endeavour.

Packet utilisation definitions for the ESA XMM mission

NASA Technical Reports Server (NTRS)

Nye, H. R.

1994-01-01

XMM, ESA's X-Ray Multi-Mirror satellite, due for launch at the end of 1999 will be the first ESA scientific spacecraft to implement the ESA packet telecommand and telemetry standards and will be the first ESOC-controlled science mission to take advantage of the new flight control system infrastructure development (based on object-oriented design and distributed-system architecture) due for deployment in 1995. The implementation of the packet standards is well defined at packet transport level. However, the standard relevant to the application level (the ESA Packet Utilization Standard) covers a wide range of on-board 'services' applicable in varying degrees to the needs of XMM. In defining which parts of the ESA PUS to implement, the XMM project first considered the mission objectives and the derived operations concept and went on to identify a minimum set of packet definitions compatible with these aspects. This paper sets the scene as above and then describes the services needed for XMM and the telecommand and telemetry packet types necessary to support each service.

Cross-cultural issues in space operations: A survey study among ground personnel of the European Space Agency

NASA Astrophysics Data System (ADS)

Sandal, Gro Mjeldheim; Manzey, Dietrich

2009-12-01

Today's space operations involve co-working of people with different ethnical, professional and organisational backgrounds. The aim of this study was to examine the implications of cultural diversity for efficient collaboration within the European Space Agency (ESA), and between ESA employees and representatives from other agencies. ESA employees from European countries ( N=576) answered to the CULT Ground Survey. The results showed that differences in relation to leadership and decision making were the most important issues thought to interfere with efficient co-working within ESA, and between ESA employees and colleagues from other agencies. Employees who collaborated with more than three nationalities within ESA indicated most challenges in co-working due to differences in compliance, behavioural norms and competitiveness. Challenges in co-working differed between agencies, and these differences were consistent with value differences in the national populations. The results may have applied value for training of European employees working in international space program teams.

Near-Earth Asteroids Astrometry with Gaia and Beyond

NASA Astrophysics Data System (ADS)

Bancelin, D.; Hestroffer, D.; Thuillot, W.

2010-05-01

Gaia is an astrometric mission from the European Space Agency (ESA) that will be launched in Spring 2012. The Gaia telescope and spectrometer will operate in the visible wavelength scanning the whole sky during 5 years (nominal mission duration). It will observe about one billion stars and QSOs but also a large number of solar system bodies, mainly asteroids, and a few comets and planetary satellites. The unprecedented accuracy of the measures both astrometric and photometric (note that the spectroscopic observations are of little scientific value for Solar System objects science) will enable to significantly improve the knowledge of the dynamics and physical properties for a large number of asteroids. With a relatively limiting magnitude somewhat reduced to V≤20 (compared to other future or ongoing surveys) Gaia will mainly oserve main-belt asteroids (MBAs), and very few TNOs or Centaurs. The Gaia telescope will also be able to observe several thousands of Near- Earth Objects (NEOs) down to low solar elongation (observation of solar system objects are performed with elongation 45° ≤ L ≤ 135°). Gaia will not be a ''big'' NEO discover, however it can possibly discover inner-Earth orbiting objects (IEOs) or sub-Atens, from atmosphereless low solar-elongation observations. In the case of discovering a new NEO target, ground-based observations in network could be needed to avoid confusion in identifying the object in the database, or loss of the target. We are aiming to generate VO-alert for such eventuality. Ground-based observations of NEOs would also more generally enter into the operational centre in construction at the IMCCE that will deal with data mining, astrometric reduction, orbit computation, alerts, etc. On the other hand, in the framework of ESA Space Situational Awareness (SSA), ground-based astrometry, possibly complemented by Gaia data, is needed to refine the orbits and collision assessment of PHAs. High accuracy astrometric and colour-photometry observations of NEOs will provide information on their taxonomy, spin state and shape, and detailed information of their orbits. Small effects acting on their dynamics can then be measured; these include link of reference frame (kinematically non rotating and dynamically non rotating one), local tests of the General Relativity and measure of the solar quadrupole J2 basically from the drift of the perihelion, test of the variation of the constant of gravity dG/dt, and detection of non gravitational effect such as the thermal Yarkovsky effect and cometary activity. Dedicated ground-based observations can be used on specific targets to complement the limited wavelength, time resolution and imaging capabilities of the Gaia telescope.

Trends in the treatment of chronic kidney disease-associated anaemia in a cohort of haemodialysis patients: the Irish experience.

PubMed

Gardiner, Roisin; Roshan, Davood; Brennan, Ann; Connolly, Denise; Murray, Susan; Reddan, Donal

2018-04-27

Anaemia among haemodialysis patients is treated with iron and erythropoietin-stimulating agents (ESAs). ESAs reduce requirements for blood transfusions but are also expensive and overzealous use may be associated with adverse outcomes. Recent international trends have been characterised by reduced ESA doses and a greater reliance on intravenous (IV) iron. We determined trends in prescribing patterns of ESAs and IV iron for the treatment of anaemia in two representative Irish dialysis centres and correlated with current guidelines and international trends. Patient data was accessed from the Kidney Disease Clinical Patient Management System (KDCPMS) for the period 2012 to 2014. We generated reports on ESA and iron doses, lab data (haemoglobin (Hb), transferrin saturation (TSAT) and ferritin) and patient population characteristics. We mapped the trends in ESA, iron dosing and lab parameters achieved. A linear mixed model determined the significance of these trends over time. ESA dosing became lower in the second, third and fourth quarters of 2014. Dosing of iron increased throughout but a large increase was seen in the third and fourth quarters of 2014. Ferritin levels decreased and TSAT and haemoglobin levels increased. Changes in iron dosing were significant with p value of < 0.05. Our findings are consistent with recent global trends toward increasing iron use. Such trends may have economic implications given the high cost of ESAs and the relative affordability of iron. In addition, the potential harm of excessive iron dosing may need to be considered.

Pharmacovigilance in practice: erythropoiesis-stimulating agents.

PubMed

Hedenus, Michael; Ludwig, Heinz; Henry, David H; Gasal, Eduard

2014-10-01

Pharmacovigilance (PV) is the science and activities relating to the detection, assessment, understanding, and prevention of adverse effects or other problems related to medical products after they have been licensed for marketing. The purpose of PV is to advance the safe use of marketed medical products. Regulatory agencies and license holders collaborate to collect data reported by health care providers, patients, and the public as well as data from systematic reviews, meta-analyses, and individual clinical and nonclinical studies. They validate and analyze the data to determine whether safety signals exist, and if warranted, develop an action plan to mitigate the identified risk. Erythropoiesis-stimulating agents (ESAs) provide an example of how PV is applied in reality. Among other approved indications, ESAs may be used to treat anemia in patients with chemotherapy-induced anemia. ESAs increase hemoglobin levels and reduce the need for transfusions; they are also associated with a known increased risk of thromboembolic events. Starting in 2003, emerging data suggested that ESAs might reduce survival. As a result of PV activities by regulatory agencies and license holders, labeling for ESAs addresses these risks. Meta-analyses and individual clinical studies have confirmed that ESAs increase the risk of thromboembolic events, but when used as indicated, ESAs have not been shown to have a significant effect on survival or disease progression. Ongoing safety studies will provide additional data in the coming years to further clarify the risks and benefits of ESAs. © 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

75 FR 52928 - Endangered and Threatened Wildlife and Plants; Notice of 90-Day Finding for a Petition to List...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

... endangered or threatened species under the Endangered Species Act (ESA). We determine that the petition does... Secretary of the Interior or the Secretary of Commerce (Secretary) to add a species to or remove a species... a species presents substantial scientific or commercial information to indicate that the petitioned...

Hello, world: Harnessing social media for the Rosetta mission

NASA Astrophysics Data System (ADS)

Baldwin, Emily; Mignone, Claudia; O'Flaherty, Karen; Homfeld, Anne-Mareike; Bauer, Markus; McCaughrean, Mark

2015-04-01

The European Space Agency's (ESA) comet-chasing Rosetta mission was launched in 2004, before social media became a popular tool for mainstream communication. By harnessing a range of platforms for communicating the key messages of this unprecedented mission as it reached its destination ten years later, new audiences were reached and a global impact was achieved. Rosetta-specific social media accounts - @ESA_Rosetta on Twitter, the Rosetta Mission Facebook page and the rosettamission Instagram account - were developed during 2013/14 and used alongside the traditional reporting line of the main ESA website and the Rosetta blog to build awareness about the mission. Coordinated with ESA's existing social media channels (Flickr, YouTube, G+, Twitter, Facebook and Livestream) and with the support of ESA's country desks and Rosetta partner agency accounts (including @philae2014), information could be shared in a number of European languages, ensuring a wide reach across Europe - and the world. We discuss the roles of the various social media accounts in supporting and promoting the competitions and social media campaigns that were built around the key mission milestones of 2014: waking up from deep space hibernation (January), arriving at Comet 67P/Churyumov-Gerasimenko (August) and naming the landing site for Philae ahead of the landing event in November. We discuss the different approach to each channel, such as the first person twitter accounts, the dialogue with and between blog users, and the discussions held live via G+ Hangouts with leading scientists and spacecraft operators. We compare and contrast the audiences, the interaction we had with them and how challenges were overcome. We also use the science-fiction-meets-science-fact Ambition short movie, and its "undercover" dissemination on social media, as an example of how the profile of the Rosetta mission was raised in a unique way. By using a variety of social media platforms to target different audiences with specific content in a coordinated way, we have been able to share the human aspect of the mission, allowing our audiences to feel part of every step of the adventure.

Hearing gestures, seeing music: vision influences perceived tone duration.

PubMed

Schutz, Michael; Lipscomb, Scott

2007-01-01

Percussionists inadvertently use visual information to strategically manipulate audience perception of note duration. Videos of long (L) and short (S) notes performed by a world-renowned percussionist were separated into visual (Lv, Sv) and auditory (La, Sa) components. Visual components contained only the gesture used to perform the note, auditory components the acoustic note itself. Audio and visual components were then crossed to create realistic musical stimuli. Participants were informed of the mismatch, and asked to rate note duration of these audio-visual pairs based on sound alone. Ratings varied based on visual (Lv versus Sv), but not auditory (La versus Sa) components. Therefore while longer gestures do not make longer notes, longer gestures make longer sounding notes through the integration of sensory information. This finding contradicts previous research showing that audition dominates temporal tasks such as duration judgment.

Technology Development Roadmap: A Technology Development Roadmap for a Future Gravitational Wave Mission

NASA Technical Reports Server (NTRS)

Camp, Jordan; Conklin, John; Livas, Jeffrey; Klipstein, William; McKenzie, Kirk; Mueller, Guido; Mueller, Juergen; Thorpe, James Ira; Arsenovic, Peter; Baker, John;

29 CFR 42.20 - Regional Farm Labor Coordinated Enforcement Committee.

Code of Federal Regulations, 2010 CFR

2010-07-01

... representatives of ESA, OSHA, ETA (the Regional MSFW Monitor Advocate), and the Office of the Regional Solicitor... is reviewed by the National Committee and appropriately revised, the regional offices of ESA, ETA... level working group in each region consisting of regional staff representatives from ESA, ETA, OSHA, the...

From SPICE to Map-Projection, the Planetary Science Archive Approach to Enhance Visibility and Usability of ESA's Space Science Data

NASA Astrophysics Data System (ADS)

Besse, S.; Vallat, C.; Geiger, B.; Grieger, B.; Costa, M.; Barbarisi, I.

2017-06-01

The Planetary Science Archive (PSA) is the European Space Agency’s (ESA) repository of science data from all planetary science and exploration missions. The PSA provides access to scientific datasets through various interfaces at http://psa.esa.int.

Flight Model Discharge System

DTIC Science & Technology

1989-09-01

Itterconnection wiring diagram for the ESA ............................... 34 3-13 Typical gain versus total count curve for CEM...42 3-16 Calibration curve for energy bin 12 of the ion ESA ....................... 43 3-17 Flight ESA S/N001...Calibration curves for SPM S/N001 ......................................... 67 4-11 Calibration curves for SPM S/N002

NASA and ESA Collaboration on Hexavalent Chrome Free Coatings

NASA Technical Reports Server (NTRS)

Greene, Brian

2017-01-01

Presentation on the NASA and ESA Collaboration on Hexavalent Chrome Free Coatings project. Project is in response to a Memorandum of Understanding between NASA and ESA Concerning Cooperation in the Field of Space Transportation - signed September 11, 2009. The National Aeronautics and Space Administration (NASA) and the European Space Agency (ESA) have expressed mutual interest in pursuing cooperation in the areas of evaluating hexavalent chrome-free coatings, environmentally-preferable coatings for maintenance of launch facilities and ground support equipment, citric acid as an alternative to nitric acid for passivation of stainless steel alloys.

Report from the Gravitational Observatory Advisory Team

NASA Astrophysics Data System (ADS)

Mueller, Guido; Gravitational Observatory Advisory Team

2016-03-01

As a response to the selection of the Gravitational Universe as the science theme for ESA's L3 mission, ESA formed the Gravitational-Wave Observatory Advisory Team (GOAT) to advise ESA on the scientific and technological approach for a gravitational wave observatory. NASA is participating with three US scientists and one NASA observer; JAXA was also invited and participates with one observer. The GOAT looked at a range of mission technologies and designs, discussed their technical readiness with respect to the ESA schedule, recommended technology development activities for selected technologies, and worked with the wider gravitational-wave community to analyze the impact on the science of the various mission designs. The final report is expected to be submitted to ESA early March and I plan to summarize its content.

Reduction in new-onset diabetes mellitus after renal transplant with erythropoietin-stimulating agents: a retrospective cohort study.

PubMed

Montada-Atin, Tess; Choi, Diana; Woo, Minna; Retnakaran, Ravi; Huang, Michael; Prasad, G V Ramesh; Zaltzman, Jeffrey S

2016-01-01

Studies have shown that erythropoietin-stimulating agents (ESAs) protect mice against the development of diabetes through direct effects on pancreatic ß cells. However, the effect of ESAs on the incidence of diabetes in humans has not been well studied. It is unknown whether exposure to ESAs is associated with a reduced incidence of new-onset diabetes after transplant (NODAT). The objective of this study is to examine the relationship between ESA exposure post-renal transplant and the development of NODAT. We performed a single center, retrospective cohort analysis. We compared patients who received a first live or deceased donor renal allograft, with any exposure to an ESA vs. those without such exposure and who developed NODAT and who did not. Patients with a prior history of diabetes mellitus or multi-organ transplant, including a second renal transplant were excluded. NODAT was defined based on the 2008 Canadian Diabetes Association criteria. Multivariate logistic regression analysis was performed to determine factors independently associated with NODAT. One hundred thirty-two (29 %) patients were exposed to an ESA, four of which developed NODAT compared to 128 who did not develop NODAT (p < 0.0001). Of those not exposed to an ESA, 15 % (48/319) developed NODAT. By Fisher's exact test, exposure to an ESA at any time post-transplant reduced the risk of developing NODAT; odds ratio (OR) = 0.08, 95 % confidence interval (CI) (0.018-0.352), p = 0.0008. Older age; OR = 1.41, 95 % CI (1.036-1.933), p < 0.02, higher random blood sugar at discharge; OR = 1.30, 95 % CI (1.077-1.57), p < 0.006 and deceased donor; OR 2.18 CI (1.009-4.729), p = 0.04 were associated with an increased risk of NODAT. The limitations of this study include its retrospective nature, single center, and homogenous population; thus, generalizability of the results must be approached with caution. ESA exposure may be associated with a reduced incidence of NODAT in the post-renal transplant population. The role of ESA in preventing NODAT requires further investigation.

Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties

PubMed Central

Gudjonsson, Thorarinn; Villadsen, René; Nielsen, Helga Lind; Rønnov-Jessen, Lone; Bissell, Mina J.; Petersen, Ole William

2002-01-01

The epithelial compartment of the human breast comprises two distinct lineages: the luminal epithelial and the myoepithelial lineage. We have shown previously that a subset of the luminal epithelial cells could convert to myoepithelial cells in culture signifying the possible existence of a progenitor cell. We therefore set out to identify and isolate the putative precursor in the luminal epithelial compartment. Using cell surface markers and immunomagnetic sorting, we isolated two luminal epithelial cell populations from primary cultures of reduction mammoplasties. The major population coexpresses sialomucin (MUC+) and epithelial-specific antigen (ESA+) whereas the minor population has a suprabasal position and expresses epithelial specific antigen but no sialomucin (MUC−/ESA+). Two cell lines were further established by transduction of the E6/E7 genes from human papilloma virus type 16. Both cell lines maintained a luminal epithelial phenotype as evidenced by expression of the tight junction proteins, claudin-1 and occludin, and by generation of a high transepithelial electrical resistance on semipermeable filters. Whereas in clonal cultures, the MUC+/ESA+ epithelial cell line was luminal epithelial restricted in its differentiation repertoire, the suprabasal-derived MUC−/ESA+ epithelial cell line was able to generate itself as well as MUC+/ESA+ epithelial cells and Thy-1+/α-smooth muscle actin+ (ASMA+) myoepithelial cells. The MUC−/ESA+ epithelial cell line further differed from the MUC+/ESA+ epithelial cell line by the expression of keratin K19, a feature of a subpopulation of epithelial cells in terminal duct lobular units in vivo. Within a reconstituted basement membrane, the MUC+/ESA+ epithelial cell line formed acinus-like spheres. In contrast, the MUC−/ESA+ epithelial cell line formed elaborate branching structures resembling uncultured terminal duct lobular units both by morphology and marker expression. Similar structures were obtained by inoculating the extracellular matrix-embedded cells subcutaneously in nude mice. Thus, MUC−/ESA+ epithelial cells within the luminal epithelial lineage may function as precursor cells of terminal duct lobular units in the human breast. PMID:11914275

Weathering the Storm - GOCE Flight Operations in 2010

NASA Astrophysics Data System (ADS)

Steiger, C.; Da Costa, A.; Floberghagen, R.; Fehringer, M.; Emanuelli, P. P.

2011-07-01

ESA's Gravity Field and Steady-State Ocean Circulation Explorer (GOCE) was successfully launched on 17th March 2009. The mission is controlled by ESA's European Space Operations Centre (ESOC) in Darmstadt, Germany. Following completion of commissioning, routine operations started in September 2009, keeping the S/C in drag-free mode at an altitude of 259.6 km. Operations are driven by the unique aspects of the mission, in particular the very low altitude and the high complexity of GOCE's drag- free control system. Following a general introduction, the main focus is put on the special events of 2010, when science operations were interrupted for several months due to problems with the main platform computer. These anomalies presented a major challenge, requiring to operate the spacecraft "in the blind" with no status information available, and extensive modifications of the on-board software to recover the mission.

InSAR Maps of Deformation Covering Raft River, Idaho from 2007 to 2010

DOE Data Explorer

Reinisch, Elena C. (ORCID:0000000252211921)

2007-03-11

This dataset contains maps of deformation covering Raft River, Idaho from 2007 to 2010 calculated from interferometric synthetic aperture radar data. This dataset is used in the study entitled "Inferring geothermal reservoir processes at the Raft River Geothermal Field, Idaho, USA through modeling InSAR-measured surface deformation" by F. Liu, et al. This dataset was derived from raw SAR data from the Envisat satellite missions operated by the European Space Agency (ESA) that are copyrighted by ESA and were provided through the WInSAR consortium at the UNAVCO facility. All pair directories use the image acquired on 3/11/2007 as a reference image. To view specific information for each grd file, please use the GMT command "grdinfo" - e.g., for grd file In20070311_20071111/drho_utm.grd, use terminal command: grdinfo In20070311_20071111/drho_utm.grd

Constraints on the core μ-gradient of the solar-like star HD 49385 via low-degree mixed modes

NASA Astrophysics Data System (ADS)

Deheuvels, S.; Michel, E.

2010-12-01

The existence of an ℓ=1 avoided crossing in the spectrum of the solar-like pulsator-target \\cible was established by Deheuvels & Michel (2009). It is the first confirmed detection of such a phenomenon. The authors showed in a preliminary modeling of the star that it was in a post main sequence status. Being a 1.3 M⊙-star, \\cible has had a convective core during its main sequence phase. The μ-gradient left by the withdrawal of this core bears information about the processes of transport at the boundary of the core. We here investigate the constraints that the observed avoided crossing brings on the μ-gradient in the core of the star. The CoRoT space mission, launched on 2006 December 27, was developed and is operated by the CNES with participation of the Science Programs of ESA; ESA's RSSD, Austria, Belgium, Brazil, Germany, and Spain.

In Search of Social Translucence: An Audit Log Analysis of Handoff Documentation Views and Updates.

PubMed

Jiang, Silis Y; Hum, R Stanley; Vawdrey, David; Mamykina, Lena

2015-01-01

Communication and information sharing are critical parts of teamwork in the hospital; however, achieving open and fluid communication can be challenging. Finding specific patient information within documentation can be difficult. Recent studies on handoff documentation tools show that resident handoff notes are increasingly used as an alternative information source by non-physician clinicians. Previous findings also show that residents have become aware of this unintended use. This study investigated the alignment of resident note updating patterns and team note viewing patterns based on usage log data of handoff notes. Qualitative interviews with clinicians were used to triangulate findings based on the log analysis. The study found that notes that were frequently updated were viewed significantly more frequently than notes updated less often (p < 2.2 × 10(-16)). Almost 44% of all notes had aligned frequency of views and updates. The considerable percentage (56%) of mismatched note utilization suggests an opportunity for improvement.

Retrospective indexing (RI) - A computer-aided indexing technique

NASA Technical Reports Server (NTRS)

Buchan, Ronald L.

1990-01-01

An account is given of a method for data base-updating designated 'computer-aided indexing' (CAI) which has been very efficiently implemented at NASA's Scientific and Technical Information Facility by means of retrospective indexing. Novel terms added to the NASA Thesaurus will therefore proceed directly into both the NASA-RECON aerospace information system and its portion of the ESA-Information Retrieval Service, giving users full access to material thus indexed. If a given term appears in the title of a record, it is given special weight. An illustrative graphic representation of the CAI search strategy is presented.

50 CFR 23.35 - What are the requirements for an import permit?

Code of Federal Regulations, 2014 CFR

2014-10-01

... IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE IN ENDANGERED SPECIES OF WILD... Elephant, and Namibian Southern White Rhinoceros Sport-hunted Trophies Appendix-I Plants Appendix-I... CITES:ESA Plants ESA Sport-hunted Trophies ESA Wildlife 3-200-36 3-200-20 3-200-37 (3) Marine Mammal...

50 CFR 23.35 - What are the requirements for an import permit?

Code of Federal Regulations, 2013 CFR

2013-10-01

... IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE IN ENDANGERED SPECIES OF WILD... Elephant, and Namibian Southern White Rhinoceros Sport-hunted Trophies Appendix-I Plants Appendix-I... CITES:ESA Plants ESA Sport-hunted Trophies ESA Wildlife 3-200-36 3-200-20 3-200-37 (3) Marine Mammal...

50 CFR 23.35 - What are the requirements for an import permit?

Code of Federal Regulations, 2010 CFR

2010-10-01

... IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE IN ENDANGERED SPECIES OF WILD... Elephant, and Namibian Southern White Rhinoceros Sport-hunted Trophies Appendix-I Plants Appendix-I... CITES:ESA Plants ESA Sport-hunted Trophies ESA Wildlife 3-200-36 3-200-20 3-200-37 (3) Marine Mammal...

50 CFR 23.35 - What are the requirements for an import permit?

Code of Federal Regulations, 2012 CFR

2012-10-01

... IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE IN ENDANGERED SPECIES OF WILD... Elephant, and Namibian Southern White Rhinoceros Sport-hunted Trophies Appendix-I Plants Appendix-I... CITES:ESA Plants ESA Sport-hunted Trophies ESA Wildlife 3-200-36 3-200-20 3-200-37 (3) Marine Mammal...

50 CFR 23.35 - What are the requirements for an import permit?

Code of Federal Regulations, 2011 CFR

2011-10-01

... IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE IN ENDANGERED SPECIES OF WILD... Elephant, and Namibian Southern White Rhinoceros Sport-hunted Trophies Appendix-I Plants Appendix-I... CITES:ESA Plants ESA Sport-hunted Trophies ESA Wildlife 3-200-36 3-200-20 3-200-37 (3) Marine Mammal...

Should Reformers Support Education Savings Accounts?

ERIC Educational Resources Information Center

Ladner, Matthew; Smith, Nelson

2016-01-01

In this article, "Education Next" talks with Matthew Ladner and Nelson Smith on the topic of Education Savings Accounts (ESAs). ESAs apply the logic of school choice to the ever-expanding realm of education offerings. Rather than simply empowering families to select the school of their choice, ESAs provide families with most or all of…

The challenges and opportunities of a commercial human spaceflight mission to the ISS.

PubMed

Belingheri, M; Mirra, C

2003-01-01

ESA astronauts' ISS flight opportunities are considered as a vital source to meet the utilisation, operation and political objectives that Europe has established for participating in the International Space Station programme. Recent internal ESA assessments have demonstrated that a rate of three flights per year for European Astronauts should be maintained as a minimum objective. The current flight rate is lower than this. In order to improve this situation, in the context of the activation of the ESA ISS Commercialisation programme, ESA is developing the conditions for the establishment of commercially based human spaceflights with the financial support of both ESA and the private sector or, in the future, only the latter. ESA is working in a Partnership with the space industry to facilitate the implementation of such projects and support customers with a range of end-to-end commercial services. The opportunities and challenges of a "commercial human spaceflight", involving a member of the European Astronaut Corps, or a privately employed flight participant, are discussed here. c2003 Elsevier Science Ltd. All rights reserved.

The European space exploration programme: current status of ESA's plans for Moon and Mars exploration.

PubMed

Messina, Piero; Vennemann, Dietrich

2005-01-01

After a large consultation with the scientific and industrial communities in Europe, the Aurora Space Exploration Programme was unanimously approved at the European Space Agency (ESA) Council at ministerial level in Edinburgh in 2001. This marked the start of the programme's preparation phase that was due to finish by the end of 2004. Aurora features technology development robotic and crewed rehearsal missions aimed at preparing a human mission to Mars by 2033. Due to the evolving context, both international and European, ESA has undertaken a review of the goals and approach of its exploration programme. While maintaining the main robotic missions that had been conceived during Aurora, the European Space Exploration Programme that is currently being proposed to the Aurora participating states and other ESA Member States has a reviewed approach and will feature a greater synergy with other ESA programmes. The paper will present the process that led to the revision of ESA's plans in the field of exploration and will give the current status of the programme. c2005 Published by Elsevier Ltd.

Safety issues related to erythropoiesis-stimulating agents used to treat anemia in patients with chronic kidney disease.

PubMed

Del Vecchio, Lucia; Locatelli, Francesco

2012-11-01

Erythropoiesis-stimulating agents (ESAs) have been the main therapy for anemia in CKD patients since the late eighties. Since then, treatment indications have progressively changed, together with a progressive increase in therapeutic targets, in terms of hemoglobin levels. This paper discusses possible concerns about ESA use and increased cardiovascular risk (in particular stroke), hypertension, cancer progression and the development of pure red cell aplasia. A literature search was done on PubMed to obtain studies about the adverse effects of ESA in the CKD population. The publication of the TREAT study has largely contributed to the concerns about ESA use, indicating that complete anemia correction may not be safe in the CKD population. This may be particularly true in high-risk patients, especially if hyporesponsive to ESA treatment. However, there is a gray area of no evidence either way for intermediate levels (11.5 - 13 g/dl), in comparison with higher or lower levels. New recommendations about ESA use in the CKD population by the Food and Drug Administration seem to move toward treatment individualization.

ESA's Integral solves thirty-year old gamma-ray mystery

NASA Astrophysics Data System (ADS)

Integral solves mystery hi-res Size hi-res: 60 kb Credits: Credit: ESA, F. Lebrun (CEA-Saclay). ESA's Integral solves thirty-year old gamma-ray mystery The central regions of our galaxy, the Milky Way, as seen by Integral in gamma rays. With its superior ability to see faint details, Integral correctly reveals the individual sources that comprised the foggy, gamma-ray background seen by previous observatories. The brightest 91 objects seen in this image were classified by Integral as individual sources, while the others appear too faint to be properly characterized at this stage. During the spring and autumn of 2003, Integral observed the central regions of our Galaxy, collecting some of the perpetual glow of diffuse low-energy gamma rays that bathe the entire Galaxy. These gamma rays were first discovered in the mid-1970s by high-flying balloon-borne experiments. Astronomers refer to them as the 'soft' Galactic gamma-ray background, with energies similar to those used in medical X-ray equipment. Initially, astronomers believed that the glow was caused by interactions involving the atoms of the gas that pervades the Galaxy. Whilst this theory could explain the diffuse nature of the emission, since the gas is ubiquitous, it failed to match the observed power of the gamma rays. The gamma rays produced by the proposed mechanisms would be much weaker than those observed. The mystery has remained unanswered for decades. Now Integral's superb gamma-ray telescope IBIS, built for ESA by an international consortium led by Principal Investigator Pietro Ubertini (IAS/CNR, Rome, Italy), has seen clearly that, instead of a fog produced by the interstellar medium, most of the gamma-rays are coming from individual celestial objects. In the view of previous, less sensitive instruments, these objects appeared to merge together. In a paper published today in "Nature", Francois Lebrun (CEA Saclay, Gif sur Yvette, France) and his collaborators report the discovery of 91 gamma-ray sources towards the direction of the Galactic centre. Lebrun's team includes Ubertini and seventeen other European scientists with long-standing experience in high-energy astrophysics. Much to the team's surprise, almost half of these sources do not fall in any class of known gamma-ray objects. They probably represent a new population of gamma-ray emitters. The first clues about a new class of gamma-ray objects came last October, when Integral discovered an intriguing gamma-ray source, known as IGRJ16318-4848. The data from Integral and ESA's other high-energy observatory XMM-Newton suggested that this object is a binary system, probably including a black hole or neutron star, embedded in a thick cocoon of cold gas and dust. When gas from the companion star is accelerated and swallowed by the black hole, energy is released at all wavelengths, mostly in the gamma rays. However, Lebrun is cautious to draw premature conclusions about the sources detected in the Galactic centre. Other interpretations are also possible that do not involve black holes. For instance, these objects could be the remains of exploded stars that are being energised by rapidly rotating celestial 'powerhouses', known as pulsars. Observations with another Integral instrument (SPI, the Spectrometer on Integral) could provide Lebrun and his team with more information on the nature of these sources. SPI measures the energy of incoming gamma rays with extraordinary accuracy and allows scientist to gain a better understanding of the physical mechanisms that generate them. However, regardless of the precise nature of these gamma-ray sources, Integral's observations have convincingly shown that the energy output from these new objects accounts for almost ninety per cent of the soft gamma-ray background coming from the centre of the Galaxy. This result raises the tantalising possibility that objects of this type hide everywhere in the Galaxy, not just in its centre. Again, Lebrun is cautious, saying, "It is tempting to think that we can simply extrapolate our results to the entire Galaxy. However, we have only looked towards its centre and that is a peculiar place compared to the rest." Next on Integral's list of things to do is to extend this work to the rest of the Galaxy. Christoph Winkler, ESA's Integral Project Scientist, says, "We now have to work on the whole disc region of the Galaxy. This will be a tough and long job for Integral. But at the end, the reward will be an exhaustive inventory of the most energetic celestial objects in the Galaxy." Note to editors The paper explaining these results will appear on the 18 March 2004 issue of "Nature". The author list includes F. Lebrun, R. Terrier, A. Bazzano, G. Belanger, A. Bird, L. Bouchet, A. Dean, M. Del Santo, A. Goldwurm, N. Lund, H. Morand, A. Parmar, J. Paul, J.-P. Roques, V. Schoenfelder, A. Strong, P. Ubertini, R. Walter and C. Winkler. For information about the related INTEGRAL and XMM-Newton discovery of IGRJ16318-4848, see: http://www.esa.int/esaSC/Pr_21_2003_s_en.html Integral The International Gamma Ray Astrophysics Laboratory (Integral) is the first space observatory that can simultaneously observe celestial objects in gamma rays, X-rays and visible light. Integral was launched on a Russian Proton rocket on 17 October 2002 into a highly elliptical orbit around Earth. Its principal targets include regions of the galaxy where chemical elements are being produced and compact objects, such as black holes. IBIS, Imager on Board the Integral Satellite - IBIS provides sharper gamma-ray images than any previous gamma-ray instrument. It can locate sources to a precision of 30 arcseconds, the equivalent of measuring the height of a person standing in a crowd, 1.3 kilometres away. The Principal Investigators that built the instrument are P. Ubertini (IAS/CNR, Rome, Italy), F. Lebrun (CEA Saclay, Gif sur Yvette, France), G. Di Cocco (ITESRE, Bologna, Italy). IBIS is equipped with the first un-cooled semiconductor gamma-ray camera, called ISGRI, which is responsible for its outstanding sensitivity. ISGRI was developed and built for ESA by CEA Saclay, France. SPI, Spectrometer on Integral - SPI measures the energy of incoming gamma rays with extraordinary accuracy. It is more sensitive to faint radiation than any previous gamma ray instrument and allows the precise nature of gamma ray sources to be determined. The Principal Investigators that developed SPI are J.-P. Roques, (CESR, Toulouse, France) and V. Schoenfelder (MPE, Garching, Germany). XMM-Newton XMM-Newton can detect more X-ray sources than any previous observatory and is helping to solve many cosmic mysteries of the violent Universe, from black holes to the formation of galaxies. It was launched on 10 December 1999, using an Ariane-5 rocket from French Guiana. Its orbit takes it almost a third of the way to the Moon, so that astronomers can enjoy long, uninterrupted views of celestial objects.

The ESA Planetary Science Archive User Group (PSA-UG)

NASA Astrophysics Data System (ADS)

Pio Rossi, Angelo; Cecconi, Baptiste; Fraenz, Markus; Hagermann, Axel; Heather, David; Rosenblatt, Pascal; Svedhem, Hakan; Widemann, Thomas

2014-05-01

ESA has established a Planetary Science Archive User Group (PSA-UG), with the task of offering independent advice to ESA's Planetary Science Archive (e.g. Heather et al., 2013). The PSA-UG is an official and independent body that continuously evaluates services and tools provided by the PSA to the community of planetary data scientific users. The group has been tasked with the following top level objectives: a) Advise ESA on future development of the PSA. b) Act as a focus for the interests of the scientific community. c) Act as an advocate for the PSA. d) Monitor the PSA activities. Based on this, the PSA-UG will report through the official ESA channels. Disciplines and subjects represented by PSA-UG members include: Remote Sensing of both Atmosphere and Solid Surfaces, Magnetospheres, Plasmas, Radio Science and Auxilliary data. The composition of the group covers ESA missions populating the PSA both now and in the near future. The first members of the PSA-UG were selected in 2013 and will serve for 3 years, until 2016. The PSA-UG will address the community through workshops, conferences and the internet. Written recommendations will be made to the PSA coordinator, and an annual report on PSA and the PSA-UG activities will be sent to the Solar System Exploration Working Group (SSEWG). Any member of the community and planetary data user can get in touch with individual members of the PSA-UG or with the group as a whole via the contacts provided on the official PSA-UG web-page: http://archives.esac.esa.int/psa/psa-ug. The PSA is accessible via: http://archives.esac.esa.int/psa References: Heather, D., Barthelemy, M., Manaud, N., Martinez, S., Szumlas, M., Vazquez, J. L., Osuna, P. and the PSA Development Team (2013) ESA's Planetary Science Archive: Status, Activities and Plans. EuroPlanet Sci. Congr. #EPSC2013-626

The ESA Initiatives towards European Technical Universities

NASA Astrophysics Data System (ADS)

Messina, P.

2002-01-01

Education is one of the ESA mandatory activities and a renewed commitment has been shown by the reinforcement of the ESA Education Office and by the launching new initiatives in addition to those already in place. The new structure of the Office includes, next to units dealing with primary and secondary schools and with other Educational projects, a service dedicated to, among other things, foster the relations with European Universities and their students. In line with the overall objectives and strategy of Education policy at ESA, the fostering of co- operation between ESA and European Universities is aimed at creating a coherent and effective framework for the two parties to mutually benefit from an enhanced collaboration. ESA has a long and successful tradition of working together Academia, especially in the field of research and development. This new initiative wants to leverage on the past and present collaboration and reinforce the links from an educational point of view. The paper will give on overview how these links are being created, the impact on the ESA offer in terms of traineeship and opportunities for young people and will draw the first conclusions from the initial experiences gathered. Also it will address the impact of the on-going europeanisation process of higher education on the relations with European Universities and on the ESA programmes offered to them. Examples of on-going co-operation will be given (e.g. Aurora Programme) with an analysis of the lesson learned. The wider European context and how ESA's efforts contribute to the creation of a European Research Area (ERA) and to the achievement of the objectives set forth by the Lisbon summit will also be touched upon. The conclusions will address the next steps in this initiative and the feedback from the various partners and how this is being taken into account to steer the it to respond to the real needs of higher education.

The ESA Scientific Exploitation of Operational Missions element

NASA Astrophysics Data System (ADS)

Desnos, Yves-Louis; Regner, Peter; Zehner, Claus; Engdahl, Marcus; Benveniste, Jerome; Delwart, Steven; Gascon, Ferran; Mathieu, Pierre-Philippe; Bojkov, Bojan; Koetz, Benjamin; Arino, Olivier; Donlon, Craig; Davidson, Malcolm; Goryl, Philippe; Foumelis, Michael

2014-05-01

The objectives of the ESA Scientific Exploitation of Operational Missions (SEOM) programme element are • to federate, support and expand the research community • to strengthen the leadership of European EO research community • to enable the science community to address new scientific research As a preparation for the SEOM element a series of international science users consultation has been organized by ESA in 2012 and 2013 In particular the ESA Living Planet Symposium was successfully organized in Edinburgh September 2013 and involving 1700 participants from 60 countries. The science users recommendations have been gathered and form the basis for the 2014 SEOM work plan approved by ESA member states. The SEOM element is organized along the following action lines: 1. Developing open-source, multi-mission, scientific toolboxes : the new toolboxes for Sentinel 1/2/3 and 5P will be introduced 2. Research and development studies: the first SEOM studies are being launched such as the INSARAP studies for Sentinel 1 interferometry in orbit demonstration , the IAS study to generate an improved spectroscopic database of the trace gas species CH4, H2O, and CO in the 2.3 μm region and SO2 in the UV region for Sentinel 5 P. In addition larger Sentinels for science call will be tendered in 2014 covering grouped studies for Sentinel 1 Land , Sentinel 1 Ocean , Sentinel 2 Land, Sentinel 3 SAR Altimetry ,Sentinel 3 Ocean color, Sentinel 3 Land and Sentinels Synergy . 3. Science users consultation : the Sentinel 2 for Science workshop is planned from 20 to 22 may 2014 at ESRIN to prepare for scientific exploitation of the Sentinel-2 mission (http://seom.esa.int/S2forScience2014 ) . In addition the FRINGE workshop focusing on scientific explotation of Sentinel1 using SAR interferometry is planned to be held at ESA ESRIN in Q2 2015 4. Training the next generation of European EO scientists on the scientific exploitation of Sentinels data: the Advanced Training course Land Remote sensing will be held in University of Valencia , Valencia, Spain from 8 to 12 September 2014 (see http://seom.esa.int/landtraining2014/index.php ). The bi-annual ESA EO summer school on "Earth System Monitoring & Modelling" will be held in ESRIN next summer (4-14 Aug 2014). (See: http://earth.eo.esa.int/trainingcourses/EOSummerSchool2012/index.php ) 5. Promoting Science data use and results : A web site has been prepared for the SEOM element and is available at: http://seom.esa.int/. Proceedings of the ESA Living Planet Symposium are in preparation to be published Q1-2014. The SEOM element plans for 2014 will be further detailed and the first results will be presented.

78 FR 10601 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition to List 44 Species of Corals as...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-14

... evaluate whether the information indicates that the species at issue faces extinction risk that is cause... a factor, but that the species may respond or may presently be responding in a negative fashion..., as well as threats which it asserts the taxa currently face, categorizing them under the ESA section...

75 FR 37385 - Endangered and Threatened Species; Initiation of a 5-Year Review of the Eastern Distinct...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-29

... Under the ESA, a list of endangered and threatened wildlife and plant species (list) must be maintained. The list is published at 50 CFR 17.11 (for animals) and 17.12 (for plants). Section 4(c)(2)(A) of the... information include the following: (A) species biology, including, but not limited to, population trends...

Ocean-Wave Coupled Modeling in COAMPS-TC: A Study of Hurricane Ivan (2004)

DTIC Science & Technology

2013-08-15

America, Stennis Space Center, MS 39529, United States a r t i c l e i n f oArticle history : Received 12 December 2012 Received in revised form 16 May 2013...Information for Society. Venice , Italy, 21– 25 September 2009. ESA Publication. Sullivan, P.P., McWilliams, J.C., Melville, W.K., 2007. Surface gravity

MOMA Gas Chromatograph-Mass Spectrometer onboard the 2018 ExoMars Mission: results and performance

NASA Astrophysics Data System (ADS)

Buch, A.; Pinnick, V. T.; Szopa, C.; Grand, N.; Humeau, O.; van Amerom, F. H.; Danell, R.; Freissinet, C.; Brinckerhoff, W.; Gonnsen, Z.; Mahaffy, P. R.; Coll, P.; Raulin, F.; Goesmann, F.

2015-10-01

The Mars Organic Molecule Analyzer (MOMA) is a dual ion source linear ion trap mass spectrometer that was designed for the 2018 joint ESA-Roscosmos mission to Mars. The main scientific aim of the mission is to search for signs of extant or extinct life in the near subsurface of Mars by acquiring samples from as deep as 2 m below the surface. MOMA will be a key analytical tool in providing chemical (molecular and chiral) information from the solid samples, with particular focus on the characterization of organic content. The MOMA instrument, itself, is a joint venture for NASA and ESA to develop a mass spectrometer capable of analyzing samples from pyrolysis/chemical derivatization gas chromatography (GC) as well as ambient pressure laser desorption ionization (LDI). The combination of the two analytical techniques allows for the chemical characterization of a broad range of compounds, including volatile and non-volatile species. Generally, MOMA can provide information on elemental and molecular makeup, polarity, chirality and isotopic patterns of analyte species. Here we report on the current performance of the MOMA prototype instruments, specifically the demonstration of the gas chromatographymass spectrometry (GC-MS) mode of operation.

Cassini/Huygens your messages en route for Titan

NASA Astrophysics Data System (ADS)

1997-02-01

This unprecedented operation will soon be coming to an end. The Internet site will not be accepting messages after 1 March 1997, although it will remain active to incorporate regularly updated information on the Cassini/Huygens mission at least until the launch in October 1997. ESA has decided to open the site to audio messages as well until 1 March 1997. Files, which must be no larger than 250 KB, should sent to the electronic letterbox sound@huygens.com in WAV or AIFF format. We shall be concluding this exceptional operation by producing a CD-ROM containing written and audio messages within the limits of the space available. We therefore propose that all media announce the forthcoming end of the operation and stress the additional possibility of sending in audio as well as written messages that will leave for Titan in October 1997. Radio or television stations wishing to offer listeners or viewers the opportunity to transmit their messages over the air can forward them to us on audio or video (Betacam) cassettes. N.B. No more than three twenty-second messages per station. For further information, please contact : ESA Public Relations Division Tel: +33.1.53.69.71.55 Fax : +33.1.53.69.76.90

Exploring the Digital Universe with Europe's Astrophysical Virtual Observatory

NASA Astrophysics Data System (ADS)

2001-12-01

N° 73-2001 - Paris, 5 December 2001 The aim of AVO is to give astronomers instant access to the vast databanks now being built up by the world's observatories and forming what is in effect a "digital sky". Using AVO astronomers will be able, for example, to retrieve the elusive traces of the passage of an asteroid as it passes the Earth and so predict its future path and perhaps warn of a possible impact. When a giant star comes to the end of its life in a cataclysmic explosion called a supernova, they will be able to access the digital sky and pinpoint the star shortly before it exploded, adding invaluable data to the study of the evolution of stars. Modern observatories observe the sky continuously and data accumulates remorselessly in the digital archives. The growth rate is impressive and many hundreds of terabytes of data -corresponding to many thousands of billions of pixels - are already available to scientists. The real sky is being digitally reconstructed in the databanks. The volume and complexity of data and information available to astronomers are overwhelming. Hence the problem of how astronomers can possibly manage, distribute and analyse this great wealth of data. The Astrophysical Virtual Observatory will enable them to meet the challenge and "put the Universe online". AVO is a three-year project, funded by the European Commission under its Research and Technological Development (RTD) scheme, to design and implement a virtual observatory for the European astronomical community. The Commission has awarded a contract valued at EUR 4m for the project, starting on 15 November. AVO will provide software tools to enable astronomers to access the multi-wavelength data archives over the Internet and so give them the capability to resolve fundamental questions about the Universe by probing the digital sky. Equivalent searches of the "real" sky would, in comparison, both be prohibitively costly and take far too long. Towards a Global Virtual Observatory The need for virtual observatories has also been recognised by other astronomical communities. The National Science Foundation in the USA has awarded $10 million (EUR 11.4 m) for a National Virtual Observatory (NVO). The AVO project team has formed a close alliance with the NVO and both teams have representatives on each other's committees. It is clear to the NVO and AVO communities that there are no intrinsic boundaries to the virtual observatory concept and that all astronomers should be working towards a truly global virtual observatory that will enable new science to be carried out on the wealth of astronomical data held in the growing number of first-class international astronomical archives. AVO involves six partner organisations led by the European Southern Observatory (ESO) in Munich. The other partner organisations are the European Space Agency (ESA), the United Kingdom's ASTROGRID consortium, the CNRS-supported Centre de Données Astronomiques de Strasbourg (CDS) at the University Louis Pasteur in Strasbourg, the CNRS-supported TERAPIX astronomical data centre at the Institut d'Astrophysique in Paris and the Jodrell Bank Observatory at the University of Manchester. Note for editors A 13-minute background video (broadcast PAL) is available from ESO PR and the Hubble European Space Agency Information Centre (addresses below). It will also be transmitted via satellite on Wednesday 12 December 2001 from 12:00 to 12:15 CET on the ESA TV Service: http://television.esa.int

34 CFR 300.2 - Applicability of this part to State and local agencies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... educational agencies (LEAs), educational service agencies (ESAs), and public charter schools that are not otherwise included as LEAs or ESAs and are not a school of an LEA or ESA. (iii) Other State agencies and schools (such as Departments of Mental Health and Welfare and State schools for children with deafness or...

Indole 3-acetic acid, indoxyl sulfate and paracresyl-sulfate do not influence anemia parameters in hemodialysis patients.

PubMed

Bataille, Stanislas; Pelletier, Marion; Sallée, Marion; Berland, Yvon; McKay, Nathalie; Duval, Ariane; Gentile, Stéphanie; Mouelhi, Yosra; Brunet, Philippe; Burtey, Stéphane

2017-07-26

The main reason for anemia in renal failure patients is the insufficient erythropoietin production by the kidneys. Beside erythropoietin deficiency, in vitro studies have incriminated uremic toxins in the pathophysiology of anemia but clinical data are sparse. In order to assess if indole 3-acetic acid (IAA), indoxyl sulfate (IS), and paracresyl sulfate (PCS) -three protein bound uremic toxins- are clinically implicated in end-stage renal disease anemia we studied the correlation between IAA, IS and PCS plasmatic concentrations with hemoglobin and Erythropoietin Stimulating Agents (ESA) use in hemodialysis patients. Between June and July 2014, we conducted an observational cross sectional study in two hemodialysis center. Three statistical approaches were conducted. First, we compared patients treated with ESA and those not treated. Second, we performed linear regression models between IAA, IS, and PCS plasma concentrations and hemoglobin, the ESA dose over hemoglobin ratio (ESA/Hemoglobin) or the ESA resistance index (ERI). Third, we used a polytomous logistic regression model to compare groups of patients with no/low/high ESA dose and low/high hemoglobin statuses. Overall, 240 patients were included in the study. Mean age ± SD was 67.6 ± 16.0 years, 55.4% were men and 42.5% had diabetes mellitus. When compared with ESA treated patients, patients with no ESA had higher hemoglobin (mean 11.4 ± 1.1 versus 10.6 ± 1.2 g/dL; p <0.001), higher transferrin saturation (TSAT, 31.1 ± 16.3% versus 23.1 ± 11.5%; p < 0.001), less frequently an IV iron prescription (52.1 versus 65.7%, p = 0.04) and were more frequently treated with hemodiafiltration (53.5 versus 36.7%). In univariate analysis, IAA, IS or PCS plasma concentrations did not differ between the two groups. In the linear model, IAA plasma concentration was not associated with hemoglobin, but was negatively associated with ESA/Hb (p = 0.02; R = 0.18) and with the ERI (p = 0.03; R = 0.17). IS was associated with none of the three anemia parameters. PCS was positively associated with hemoglobin (p = 0.03; R = 0.14), but negatively with ESA/Hb (p = 0.03; R = 0.17) and the ERI (p = 0.02; R = 0.19). In multivariate analysis, the association of IAA concentration with ESA/Hb or ERI was not statistically significant, neither was the association of PCS with ESA/Hb or ERI. Identically, in the subgroup of 76 patients with no inflammation (CRP <5 mg/L) and no iron deficiency (TSAT >20%) linear regression between IAA, IS or PCS and any anemia parameter did not reach significance. In the third model, univariate analysis showed no intergroup significant differences for IAA and IS. Regarding PCS, the Low Hb/High ESA group had lower concentrations. However, when we compared PCS with the other significant characteristics of the five groups to the Low Hb/high ESA (our reference group), the polytomous logistic regression model didn't show any significant difference for PCS. In our study, using three different statistical models, we were unable to show any correlation between IAA, IS and PCS plasmatic concentrations and any anemia parameter in hemodialysis patients. Indolic uremic toxins and PCS have no or a very low effect on anemia parameters.

Basic Radar Altimetry Toolbox: Tools and Tutorial To Use Radar Altimetry For Cryosphere

NASA Astrophysics Data System (ADS)

Benveniste, J. J.; Bronner, E.; Dinardo, S.; Lucas, B. M.; Rosmorduc, V.; Earith, D.

2010-12-01

Radar altimetry is very much a technique expanding its applications. If quite a lot of efforts have been made for oceanography users (including easy-to-use data), the use of those data for cryosphere application, especially with the new ESA CryoSat-2 mission data is still somehow tedious, especially for new Altimetry data products users. ESA and CNES thus had the Basic Radar Altimetry Toolbox developed a few years ago, and are improving and upgrading it to fit new missions and the growing number of altimetry uses. The Basic Radar Altimetry Toolbox is an "all-altimeter" collection of tools, tutorials and documents designed to facilitate the use of radar altimetry data. The software is able: - to read most distributed radar altimetry data, from ERS-1 & 2, Topex/Poseidon, Geosat Follow-on, Jason-1, Envisat, Jason- 2, CryoSat and the future Saral missions, - to perform some processing, data editing and statistic, - and to visualize the results. It can be used at several levels/several ways: - as a data reading tool, with APIs for C, Fortran, Matlab and IDL - as processing/extraction routines, through the on-line command mode - as an educational and a quick-look tool, with the graphical user interface As part of the Toolbox, a Radar Altimetry Tutorial gives general information about altimetry, the technique involved and its applications, as well as an overview of past, present and future missions, including information on how to access data and additional software and documentation. It also presents a series of data use cases, covering all uses of altimetry over ocean, cryosphere and land, showing the basic methods for some of the most frequent manners of using altimetry data. It is an opportunity to teach remote sensing with practical training. It has been available from April 2007, and had been demonstrated during training courses and scientific meetings. About 1200 people downloaded it (Summer 2010), with many "newcomers" to altimetry among them, including teachers and professors. Users' feedback, developments in altimetry, and practice, showed that new interesting features could be added. Some have been added and/or improved in version 2. Others are under development, some are in discussion for the future. Data use cases on cryosphere applications will be presented. BRAT is developed under contract with ESA and CNES. It is available at http://www.altimetry.info and http://earth.esa.int/brat/

The ESA Planetary Science Archive User Group (PSA-UG)

NASA Astrophysics Data System (ADS)

Rossi, A. P.; Cecconi, B.; Fraenz, M.; Hagermann, A.; Heather, D.; Rosenblatt, P.; Svedhem, H.; Widemann, T.

2014-04-01

ESA has established a Planetary Science Archive User Group (PSA-UG), with the task of offering independent advice to ESA's Planetary Science Archive (e.g. Heather et al., 2013). The PSA-UG is an official and independent body that continuously evaluates services and tools provided by the PSA to the community of planetary data scientific users. The group has been tasked with the following top level objectives: a) Advise ESA on future development of the PSA. b) Act as a focus for the interests of the scientific community. c) Act as an advocate for the PSA. d) Monitor the PSA activities. Based on this, the PSA-UG will report through the official ESA channels. Disciplines and subjects represented by PSA-UG members include: Remote Sensing of both Atmosphere and Solid Surfaces, Magnetospheres, Plasmas, Radio Science and Auxilliary data. The composition of the group covers ESA missions populating the PSA both now and in the near future. The first members of the PSA-UG were selected in 2013 and will serve for 3 years, until 2016. The PSA-UG will address the community through workshops, conferences and the internet. Written recommendations will be made to the PSA coordinator, and an annual report on PSA and the PSA-UG activities will be sent to the Solar System Exploration Working Group (SSEWG). Any member of the community and planetary data user can get in touch with individual members of the PSA-UG or with the group as a whole via the contacts provided on the official PSA-UG web-page: http://archives.esac.esa.int/psa/psa-ug The PSA is accessible via: http://archives.esac.esa.int/psa

Activities on space debris in Europe

NASA Astrophysics Data System (ADS)

Flury, W.

2001-10-01

Activities on space debris in Europe are carried out by ESA, by national space agencies such as ASI (Italy), BNSC (United Kingdom), CNES (France) and DLR (Germany) and by various research groups. The objectives of ESA's activities in the field of space debris have been defined by the Council of ESA in 1989, and were updated in 2000 with the adoption of the Resolution for a European policy on the protection of the space environment from debris. ESA's debris-related activities comprise research, application of debris mitigation measures and international cooperation. The research activities address the knowledge of the terrestrial particulate environment, risk assessment, hypervelocity impacts and protection, and preventative measures. In all these areas substantial progress has been achieved. Examples are the MASTER 99 model, the DISCOS database, beam-park experiments with the FGAN radar, the discovery of a small-size debris population in GEO with the Space Debris telescope at the Teide observatory, and the GORID dust detector in the geostationary orbit. The ESA Space Debris Mitigation Handbook was issued, and in a joint effort of ESA and the national agencies ASI, BNSC, CNES and DLR the European Space Debris Safety and Mitigation Standard (draft) was established. This standard will be harmonized with standards of other agencies through the deliberations in the Inter-Agency Space Debris Coordination Committee (IADC). In order to strengthen the European cooperation, the pilot network of centers - Working Group on Space Debris was created in 2000. The members are ESA, ASI, BNSC, CNES and DLR. An integrated work plan has been established for the period 2001-2003. Global cooperation among the space-faring nations is achieved through the IADC. ESA and its Member States strongly support the deliberations on space debris within the United Nations Committee on the Peaceful Uses of Outer Space (UNCOPUOS).

American Society of Hematology/American Society of Clinical Oncology clinical practice guideline update on the use of epoetin and darbepoetin in adult patients with cancer.

PubMed

Rizzo, J Douglas; Brouwers, Melissa; Hurley, Patricia; Seidenfeld, Jerome; Arcasoy, Murat O; Spivak, Jerry L; Bennett, Charles L; Bohlius, Julia; Evanchuk, Darren; Goode, Matthew J; Jakubowski, Ann A; Regan, David H; Somerfield, Mark R

2010-11-18

To update American Society of Hematology/American Society of Clinical Oncology recommendations for use of erythropoiesis-stimulating agents (ESAs) in patients with cancer. An Update Committee reviewed data published between January 2007 and January 2010. MEDLINE and the Cochrane Library were searched. The literature search yielded one new individual patient data analysis and four literature-based meta-analyses, two systematic reviews, and 13 publications reporting new results from randomized controlled trials not included in prior or new reviews. For patients undergoing myelosuppressive chemotherapy who have a hemoglobin (Hb) level less than 10 g/dL, the Update Committee recommends that clinicians discuss potential harms (eg, thromboembolism, shorter survival) and benefits (eg, decreased transfusions) of ESAs and compare these with potential harms (eg, serious infections, immune-mediated adverse reactions) and benefits (eg, rapid Hb improvement) of RBC transfusions. Individual preferences for assumed risk should contribute to shared decisions on managing chemotherapy-induced anemia. The Committee cautions against ESA use under other circumstances. If used, ESAs should be administered at the lowest dose possible and should increase Hb to the lowest concentration possible to avoid transfusions. Available evidence does not identify Hb levels ≥ 10 g/dL either as thresholds for initiating treatment or as targets for ESA therapy. Starting doses and dose modifications after response or nonresponse should follow US Food and Drug Administration-approved labeling. ESAs should be discontinued after 6 to 8 weeks in nonresponders. ESAs should be avoided in patients with cancer not receiving concurrent chemotherapy, except for those with lower risk myelodysplastic syndromes. Caution should be exercised when using ESAs with chemotherapeutic agents in diseases associated with increased risk of thromboembolic complications. Table 1 lists detailed recommendations.

American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update on the use of epoetin and darbepoetin in adult patients with cancer.

PubMed

Rizzo, J Douglas; Brouwers, Melissa; Hurley, Patricia; Seidenfeld, Jerome; Arcasoy, Murat O; Spivak, Jerry L; Bennett, Charles L; Bohlius, Julia; Evanchuk, Darren; Goode, Matthew J; Jakubowski, Ann A; Regan, David H; Somerfield, Mark R

2010-11-20

To update American Society of Clinical Oncology/American Society of Hematology recommendations for use of erythropoiesis-stimulating agents (ESAs) in patients with cancer. An Update Committee reviewed data published between January 2007 and January 2010. MEDLINE and the Cochrane Library were searched. The literature search yielded one new individual patient data analysis and four literature-based meta-analyses, two systematic reviews, and 13 publications reporting new results from randomized controlled trials not included in prior or new reviews. For patients undergoing myelosuppressive chemotherapy who have a hemoglobin (Hb) level less than 10 g/dL, the Update Committee recommends that clinicians discuss potential harms (eg, thromboembolism, shorter survival) and benefits (eg, decreased transfusions) of ESAs and compare these with potential harms (eg, serious infections, immune-mediated adverse reactions) and benefits (eg, rapid Hb improvement) of RBC transfusions. Individual preferences for assumed risk should contribute to shared decisions on managing chemotherapy-induced anemia. The Committee cautions against ESA use under other circumstances. If used, ESAs should be administered at the lowest dose possible and should increase Hb to the lowest concentration possible to avoid transfusions. Available evidence does not identify Hb levels ≥ 10 g/dL either as thresholds for initiating treatment or as targets for ESA therapy. Starting doses and dose modifications after response or nonresponse should follow US Food and Drug Administration-approved labeling. ESAs should be discontinued after 6 to 8 weeks in nonresponders. ESAs should be avoided in patients with cancer not receiving concurrent chemotherapy, except for those with lower risk myelodysplastic syndromes. Caution should be exercised when using ESAs with chemotherapeutic agents in diseases associated with increased risk of thromboembolic complications. Table 1 lists detailed recommendations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zack, J; Natenberg, E J; Knowe, G V

The overall goal of this multi-phased research project known as WindSENSE is to develop an observation system deployment strategy that would improve wind power generation forecasts. The objective of the deployment strategy is to produce the maximum benefit for 1- to 6-hour ahead forecasts of wind speed at hub-height ({approx}80 m). In this phase of the project the focus is on the Mid-Columbia Basin region which encompasses the Bonneville Power Administration (BPA) wind generation area shown in Figure 1 that includes Klondike, Stateline, and Hopkins Ridge wind plants. The Ensemble Sensitivity Analysis (ESA) approach uses data generated by a setmore » (ensemble) of perturbed numerical weather prediction (NWP) simulations for a sample time period to statistically diagnose the sensitivity of a specified forecast variable (metric) for a target location to parameters at other locations and prior times referred to as the initial condition (IC) or state variables. The ESA approach was tested on the large-scale atmospheric prediction problem by Ancell and Hakim 2007 and Torn and Hakim 2008. ESA was adapted and applied at the mesoscale by Zack et al. (2010a, b, and c) to the Tehachapi Pass, CA (warm and cools seasons) and Mid-Colombia Basin (warm season only) wind generation regions. In order to apply the ESA approach at the resolution needed at the mesoscale, Zack et al. (2010a, b, and c) developed the Multiple Observation Optimization Algorithm (MOOA). MOOA uses a multivariate regression on a few select IC parameters at one location to determine the incremental improvement of measuring multiple variables (representative of the IC parameters) at various locations. MOOA also determines how much information from each IC parameter contributes to the change in the metric variable at the target location. The Zack et al. studies (2010a, b, and c), demonstrated that forecast sensitivity can be characterized by well-defined, localized patterns for a number of IC variables such as 80-m wind speed and vertical temperature difference. Ideally, the data assimilation scheme used in the experiments would have been based upon an ensemble Kalman filter (EnKF) that was similar to the ESA method used to diagnose the Mid-Colombia Basin sensitivity patterns in the previous studies. However, the use of an EnKF system at high resolution is impractical because of the very high computational cost. Thus, it was decided to use the three-dimensional variational analysis data assimilation that is less computationally intensive and more economically practical for generating operational forecasts. There are two tasks in the current project effort designed to validate the ESA observational system deployment approach in order to move closer to the overall goal: (1) Perform an Observing System Experiment (OSE) using a data denial approach which is the focus of this task and report; and (2) Conduct a set of Observing System Simulation Experiments (OSSE) for the Mid-Colombia basin region. The results of this task are presented in a separate report. The objective of the OSE task involves validating the ESA-MOOA results from the previous sensitivity studies for the Mid-Columbia Basin by testing the impact of existing meteorological tower measurements on the 0- to 6-hour ahead 80-m wind forecasts at the target locations. The testing of the ESA-MOOA method used a combination of data assimilation techniques and data denial experiments to accomplish the task objective.« less

NASA AND ESA Partnership on the Multi-Purpose Crew Vehicle Service Module

NASA Technical Reports Server (NTRS)

Free, James M.; Schubert, Kathleen; Grantier, Julie

2012-01-01

In March 2011, NASA and ESA made a decision to partially offset the European obligations deriving from the extension of the ISS Program until the end of 2020 with different means than ATVs, following the ATV-5 mission foreseen in mid-2014. NASA and ESA considered a number of barter options, and concluded that the provision by ESA of the Service Module and Spacecraft Adaptor for the NASA Multi-Purpose Crew Vehicle (MPCV) was the barter element with the most interest. A joint ESA - NASA working group was established to assess the feasibility of Europe developing this Module based on ATV heritage. The working group was supported by European and US industry namely Astrium, TAS-I and Lockheed-Martin. This paper gives an overview of the results of the on-going study as well as its projected utilization for the global space exploration endeavour.

Bioeconomic analysis supports the endangered species act.

PubMed

Salau, Kehinde R; Fenichel, Eli P

2015-10-01

The United States Endangered Species Act (ESA) was enacted to protect and restore declining fish, wildlife, and plant populations. The ESA mandates endangered species protection irrespective of costs. This translates to the restriction of activities that harm endangered populations. We discuss criticisms of the ESA in the context of public land management and examine under what circumstance banning non-conservation activity on multiple use federal lands can be socially optimal. We develop a bioeconomic model to frame the species management problem under the ESA and identify scenarios where ESA-imposed regulations emerge as optimal strategies. Results suggest that banning harmful activities is a preferred strategy when valued endangered species are in decline or exposed to poor habitat quality. However, it is not optimal to sustain such a strategy in perpetuity. An optimal plan involves a switch to land-use practices characteristic of habitat conservation plans.

The role of the pharmacist in optimizing the use of erythropoietin stimulating agents.

PubMed

Gebara, Shereen Nabhani; Moubayed, Hiba

2010-03-01

With the emerging new warnings surrounding the use of erythropoiesis-stimulating agents (ESAs), the pharmacist's role as health educator and risk communicator expands further to include patient scrutiny to check for eligibility and patient monitoring to check for response or toxicity. This review explores the benefits and risks linked to ESAs use, and the proposed role. ESAs have been increasingly used for the treatment of chemotherapy-induced anemia because of its documented effect on decreasing transfusion dependency. However, their use has been associated with thromboembolic complications, tumor progression, and decreased overall survival. This review covers current recommendations and guidelines that surround ESAs use in the supportive care of cancer patients. To minimize or prevent the complications associated with ESAs use, cancer patients should be adequately monitored and counseled. This highlights the importance of the pharmacist's involvement to optimize patient care.

The ESA Gaia Archive: Data Release 1

NASA Astrophysics Data System (ADS)

Salgado, J.; González-Núñez, J.; Gutiérrez-Sánchez, R.; Segovia, J. C.; Durán, J.; Hernández, J. L.; Arviset, C.

2017-10-01

The ESA Gaia mission is producing the most accurate source catalogue in astronomy to date. This represents a challenge in archiving to make the information and data accessible to astronomers in an efficient way, due to the size and complexity of the data. Also, new astronomical missions, taking larger and larger volumes of data, are reinforcing this change in the development of archives. Archives, as simple applications to access data, are evolving into complex data centre structures where computing power services are available for users and data mining tools are integrated into the server side. In the case of astronomy missions that involve the use of large catalogues, such as Gaia (or Euclid to come), the common ways to work on the data need to be changed to the following paradigm: "move the code close to the data". This implies that data mining functionalities are becoming a must to allow for the maximum scientific exploitation of the data. To enable these capabilities, a TAP+ interface, crossmatch capabilities, full catalogue histograms, serialisation of intermediate results in cloud resources, such as VOSpace etc., have been implemented for the Gaia Data Release 1 (DR1), to enable the exploitation of these science resources by the community without any bottlenecks in the connection bandwidth. We present the architecture, infrastructure and tools already available in the Gaia Archive DR1 (http://archives.esac.esa.int/gaia/) and we describe the capabilities and infrastructure.

European plans for new clocks in space

NASA Technical Reports Server (NTRS)

Leschiutta, Sigfrido M.; Tavella, Patrizia

1995-01-01

An outline of the future European space research program where precise clocks are necessary is presented, pointing out how space applications are posing impressive requirements as regards clock mass, power, ruggedness, long life, accuracy and, in some cases, spectral purity. The material presented was gathered in some laboratories; useful information was obtained from the Space Agencies of France (CNES), Germany (DARA) and Italy (ASI), but the bulk is coming from a recent exercise promoted inside ESA (the European Space Agency) and aimed to prefigure space research activities at the beginning of the next millennium. This exercise was called Horizon 2000 plus; the outcomings were summarized in two reports, presented by ESA in may 1994. Precise clocks and time measurements are needed not only for deep-space or out-ward space missions, but are essential tools also for Earth oriented activities. In this latter field, the European views and needs were discussed in October 1994, in a meeting organized by ESA and devoted to Earth Observation problems. By a scrutiny of these reports, an analysis was performed on the missions requiring a precise clock on board and the driving requirements were pointed out, leading to a survey of the necessary PTTI developments that, to some extent, are in the realm of possibility but that pose serious challenges. In this report the use of frequency standards in the satellite navigation systems is not considered.

Evaluating ESA CCI soil moisture in East Africa.

PubMed

McNally, Amy; Shukla, Shraddhanand; Arsenault, Kristi R; Wang, Shugong; Peters-Lidard, Christa D; Verdin, James P

2016-06-01

To assess growing season conditions where ground based observations are limited or unavailable, food security and agricultural drought monitoring analysts rely on publicly available remotely sensed rainfall and vegetation greenness. There are also remotely sensed soil moisture observations from missions like the European Space Agency (ESA) Soil Moisture and Ocean Salinity (SMOS) and NASA's Soil Moisture Active Passive (SMAP), however these time series are still too short to conduct studies that demonstrate the utility of these data for operational applications, or to provide historical context for extreme wet or dry events. To promote the use of remotely sensed soil moisture in agricultural drought and food security monitoring, we use East Africa as a case study to evaluate the quality of a 30+ year time series of merged active-passive microwave soil moisture from the ESA Climate Change Initiative (CCI-SM). Compared to the Normalized Difference Vegetation index (NDVI) and modeled soil moisture products, we found substantial spatial and temporal gaps in the early part of the CCI-SM record, with adequate data coverage beginning in 1992. From this point forward, growing season CCI-SM anomalies were well correlated (R>0.5) with modeled, seasonal soil moisture, and in some regions, NDVI. We use correlation analysis and qualitative comparisons at seasonal time scales to show that remotely sensed soil moisture can add information to a convergence of evidence framework that traditionally relies on rainfall and NDVI in moderately vegetated regions.

Methods of analysis by the U.S. Geological Survey Organic Geochemistry Research Group; determination of chloroacetanilide herbicide metabolites in water using high-performance liquid chromatography-diode array detection and high-performance liquid chromatography/mass spectrometry

USGS Publications Warehouse

Zimmerman, L.R.; Hostetler, K.A.; Thurman, E.M.

2000-01-01

Analytical methods using high-performance liquid chromatography-diode array detection (HPLC-DAD) and high-performance liquid chromatography/mass spectrometry (HPLC/MS) were developed for the analysis of the following chloroacetanilide herbicide metabolites in water: acetochlor ethanesulfonic acid (ESA), acetochlor oxanilic acid (OXA), alachlor ESA, alachlor OXA, metolachlor ESA, and metolachlor OXA. Good precision and accuracy were demonstrated for both the HPLC-DAD and HPLC/MS methods in reagent water, surface water, and ground water. The mean HPLC-DAD recoveries of the chloroacetanilide herbicide metabolites from water samples spiked at 0.25, 0.50, and 2.0 mg/L (micrograms per liter) ranged from 84 to 112 percent, with relative standard deviations of 18 percent or less. The mean HPLC/MS recoveries of the metabolites from water samples spiked at 0.05, 0.20, and 2.0 mg/L ranged from 81 to 125 percent, with relative standard deviations of 20 percent or less. The limit of quantitation (LOQ) for all metabolites using the HPLC-DAD method was 0.20 mg/L, whereas the LOQ using the HPLC/MS method was 0.05 mg/L. These metabolite-determination methods are valuable for acquiring information about water quality and the fate and transport of the parent chloroacetanilide herbicides in water.

Determination of chloroacetanilide herbicide metabolites in water using high-performance liquid chromatography-diode array detection and high-performance liquid chromatography/mass spectrometry

USGS Publications Warehouse

Hostetler, K.A.; Thurman, E.M.

2000-01-01

Analytical methods using high-performance liquid chromatography-diode array detection (HPLC-DAD) and high-performance liquid chromatography/mass spectrometry (HPLC/MS) were developed for the analysis of the following chloroacetanilide herbicide metabolites in water: alachlor ethanesulfonic acid (ESA); alachlor oxanilic acid; acetochlor ESA; acetochlor oxanilic acid; metolachlor ESA; and metolachlor oxanilic acid. Good precision and accuracy were demonstrated for both the HPLC-DAD and HPLC/MS methods in reagent water, surface water, and ground water. The average HPLC-DAD recoveries of the chloroacetanilide herbicide metabolites from water samples spiked at 0.25, 0.5 and 2.0 ??g/l ranged from 84 to 112%, with relative standard deviations of 18% or less. The average HPLC/MS recoveries of the metabolites from water samples spiked at 0.05, 0.2 and 2.0 ??g/l ranged from 81 to 118%, with relative standard deviations of 20% or less. The limit of quantitation (LOQ) for all metabolites using the HPLC-DAD method was 0.20 ??g/l, whereas the LOQ using the HPLC/MS method was at 0.05 ??g/l. These metabolite-determination methods are valuable for acquiring information about water quality and the fate and transport of the parent chloroacetanilide herbicides in water. Copyright (C) 2000 Elsevier Science B.V.

Detection of EPO doping and blood doping: the haematological module of the Athlete Biological Passport.

PubMed

Schumacher, Yorck Olaf; Saugy, Martial; Pottgiesser, Torben; Robinson, Neil

2012-11-01

The increase of the body's capacity to transport oxygen is a prime target for doping athletes in all endurance sports. For this pupose, blood transfusions or erythropoiesis stimulating agents (ESA), such as erythropoietin, NESP, and CERA are used. As direct detection of such manipulations is difficult, biomarkers that are connected to the haematopoietic system (haemoglobin concentration, reticulocytes) are monitored over time (Athlete Biological Passport (ABP)) and analyzed using mathematical models to identify patterns suspicious of doping. With this information, athletes can either be sanctioned directly based on their profile or targeted with conventional doping tests. Key issues for the appropriate use of the ABP are correct targeting and use of all available information (e.g. whereabouts, cross sectional population data) in a forensic manner. Future developments of the passport include the correction of all concentration-based variables for shifts in plasma volume, which might considerably increase sensitivity. New passport markers from the genomic, proteomic, and metabolomic level might add further information, but need to be validated before integration into the passport procedure. A first assessment of blood data of federations that have implemented the passport show encouraging signs of a decreased blood-doping prevalence in their athletes, which adds scientific credibility to this innovative concept in the fight against ESA- and blood doping. Copyright © 2012 John Wiley & Sons, Ltd.

Topographic evolution of a continental indenter: The eastern Southern Alps

NASA Astrophysics Data System (ADS)

Robl, Jörg; Heberer, Bianca; Prasicek, Günther; Neubauer, Franz; Hergarten, Stefan

2017-04-01

The topographic evolution of the eastern Southern Alps (ESA) is controlled by the Late Oligocene - Early Miocene indentation of the Adriatic microplate into an overthickened orogenic wedge emplaced on top of the European plate. Rivers follow topographic gradients that evolve during continental collision and in turn incise into bedrock counteracting the formation of topography. In principle, erosional surface processes tend to establish a topographic steady state so that an interpretation of topographic metrics in terms of the latest tectonic history should be straightforward. However, a series of complications impede deciphering the topographic record of the ESA. The Pleistocene glaciations locally excavated alpine valleys and perturbed fluvial drainages. The Late Miocene desiccation of the Mediterranean Sea and the uplift of the northern Molasse Basin led to significant base level changes in the far field of the ESA and the Eastern Alps (EA), respectively. Among this multitude of mechanisms, the processes that dominate the current topographic evolution of the ESA and the ESA-EA drainage divide have not been identified and a number of questions regarding the interaction of crustal deformation, erosion and climate in shaping the present-day topography remain. We demonstrate the expected topographic effects of each mechanism in a 1-dimensional model and compare them with observed channel metrics. Modern uplift rates are largely consistent with long-term exhumation in the ESA and with variations in the normalized steepness index (ksn) indicating a stable uplift and erosion pattern since Miocene times. We find that ksn increases with uplift rate and declines from the indenter tip in the northwest to the foreland basin in the southeast. The number and magnitude of knickpoints and the distortion in longitudinal channel profiles similarly decrease towards the east. Most knickpoints probably evolved during Pleistocene glaciation cycles, but may represent the incrementally reactivated, buried incision signal triggered by the Messinian desiccation of the Mediterranean Sea. Changes in slope of χ-transformed channel profiles coincide spatially with the Valsugana - Fella fault linking crustal stacking and uplift induced by indenter tectonics with topographic evolution. Gradients in χ across the ESA-EA drainage divide imply an ongoing, north-directed shift of the Danube-ESA watershed. This implies that ESA streams spread to the domain of the EA by drainage divide migration and river capture events. As already observed in the Adige catchment, the Periadriatic fault system loses its significance for the morphological evolution of the EA-ESA. The observed northward migration of the ESA-EA drainage divide is most likely driven by a base level rise in the northern Molasse basin, which leads to a growth of the ESA and Rhine catchments at the expense of the Danube drainage area. We conclude that the regional uplift pattern controls the geometry of ESA-EA channels, while base level changes in the far field control the overall architecture of the orogen by drainage divide migration (Robl et al., 2016). Robl, J., B. Heberer, G. Prasicek, F. Neubauer, and S. Hergarten (2016), The topography of a continental indenter: The interplay between crustal deformation, erosion and base level changes in the eastern Southern Alps, J. Geophys. Res. Earth Surf., 121, doi:10.1002/2016JF003884.

Challenges for Children and Women in the 1990s: Eastern and Southern Africa in Profile.

ERIC Educational Resources Information Center

United Nations Children's Fund, Nairobi (Kenya). Eastern and Southern Africa Regional Office.

This report profiles conditions in the lives of children and women in Eastern and Southern Africa (ESA), and attempts to identify and analyze trends and issues which are emerging in ESA and which have particular significance for UNICEF activities. During the 1980s, ESA experienced unprecedented economic decline due to falling commodity prices and…

Sentinel-1 - the radar mission for GMES operational land and sea services

NASA Astrophysics Data System (ADS)

Attema, Evert; Bargellini, Pierre; Edwards, Peter; Levrini, Guido; Lokas, Svein; Moeller, Ludwig; Rosich-Tell, Betlem; Secchi, Patrizia; Torres, Ramon; Davidson, Malcolm; Snoeij, Paul

2007-08-01

The ESA Sentinels will be the first series of operational satellites to meet the Earth observation needs of the European Union - ESA Global Monitoring for Environment and Security (GMES) programme. Existing and planned space assets will be complemented by new developments from ESA. The first is Sentinel-1, a pair of synthetic aperture radar (SAR) imaging satellites.

Technology developments under consideration for future ground systems

NASA Astrophysics Data System (ADS)

Drewes, G. W. J.

A review is conducted of those areas of ground-system related technology which require for their appropriate development funding provided by ESA. ESA will, in this connection, financially support the development of a coaxial S and X band feed horn for use with its 15-m antenna for Villafranca and Carnarvon. With respect to RF techology, it is found that the required RF components and subsystems will be available, and, consequently, ESA will not provide any funds for developments in this area. Other sectors examined with respect to possible developments requiring ESA funding are related to modulation/demodulation, spacecraft position, data handling, timing, and development and standardization.

Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester, a polymeric colon-specific prodrug releasing 5-aminosalicylic acid and benzocaine, ameliorates TNBS-induced rat colitis.

PubMed

Nam, Joon; Kim, Wooseong; Lee, Sunyoung; Jeong, Seongkeun; Yoo, Jin-Wook; Kim, Min-Soo; Jung, Yunjin

2016-01-01

Local anesthetics have beneficial effects on colitis. Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester (Dex-5-ESA), designed as a polymeric colon-specific prodrug liberating 5-ASA and benzocaine in the large intestine, was prepared and its therapeutic activity against colitis was evaluated using a TNBS-induced rat colitis model. Dex-5-ESA liberated 5-ASA and benzocaine in the cecal contents while (bio)chemically stable in the small intestinal contents and mucosa. Oral administration of Dex-5-ESA (equivalent to 10 mg 5-ASA/kg, twice a day) alleviated colonic injury and reduced MPO activity in the inflamed colon. In parallel, pro-inflammatory mediators, COX-2, iNOS and CINC-3, elevated by TNBS-induced colitis, were substantially diminished in the inflamed colon. Dex-5-ESA was much more effective for the treatment of colitis than 5-(4-ethoxycarbonylphenylazo)salicylic acid (5-ESA) that may not deliver benzocaine to the large intestine. Our data suggest that Dex-5-ESA is a polymeric colon-specific prodrug, liberating 5-ASA and benzocaine in the target site (large intestine), probably exerting anti-colitic effects by combined action of 5-ASA and benzocaine.

Effect of Fasciola gigantica excretory secretory antigen on rat hematological indices

PubMed Central

Ganga, G.; Sharma, R. L.

2006-01-01

The present study was undertaken to investigate the effect of Fasciola gigantica excretory secretory antigen (Fg-ESA) on rat hematological indices. Fg-ESA was prepared by keeping thoroughly washed 40 F. gigantica flukes in 100 ml phosphate buffer saline (PBS) for 2 h at 37℃, and centrifuging the supernatant at 12,000 g at 4℃ for 30 min. The protein content of Fg-ESA was adjusted to 1.8 mg/ml. The rats were randomly divided into two groups of six rats each. Rats in group A received 0.5 ml of Fg-ESA intraperitoneally (i.p.) for 7 days, whereas control rats in group B received 0.5 ml of PBS i.p. for 7 days. Hemograms of both groups were studied initially and on days 0, 2, 4, 14 and 21 after the final injection of Fg-ESA or PBS. Progressive and significant (p < 0.01) declines in the values of hemoglobin, hematocrit, and total erythrocyte count were observed without significant (p > 0.05) changes in the values of mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, or mean corpuscular volume in group A. Thus, we conclude that Fg-ESA induces normocytic normochromic anemia in rats. PMID:16645335

Performance of external and internal coil configurations for prostate investigations at 7 Tesla

PubMed Central

Metzger, Gregory J.; van de Moortele, Pierre-Francois; Akgun, Can; Snyder, Carl J.; Moeller, Steen; Strupp, John; Andersen, Peter; Shrivastava, Devashish; Vaughan, Tommy; Ugurbil, Kamil; Adriany, Gregor

2010-01-01

Three different coil configurations were evaluated through simulation and experimentally to determine safe operating limits and evaluate subject size dependent performance for prostate imaging at 7 Tesla. The coils included a transceiver endorectal coil (trERC), a 16 channel transceiver external surface array (trESA) and a trESA combined with a receive-only ERC (trESA+roERC). While the transmit B1 (B1+) homogeneity was far superior for the trESA, the maximum achievable B1+ is subject size dependent and limited by transmit chain losses and amplifier performance. For the trERC, limitations in transmit homogeneity greatly compromised image quality and limited coverage of the prostate. Despite these challenges, the high peak B1+ close to the trERC and subject size independent performance provides potential advantages especially for spectroscopic localization where high bandwidth RF pulses are required. On the receive side, the combined trESA+roERC provided the highest SNR and improved homogeneity over the trERC resulting in better visualization of the prostate and surrounding anatomy. In addition, the parallel imaging performance of the trESA+roERC holds strong promise for diffusion weighted imaging and dynamic contrast enhanced MRI. PMID:20740657

The Composer's Program Note for Newly Written Classical Music: Content and Intentions.

PubMed

Blom, Diana M; Bennett, Dawn; Stevenson, Ian

2016-01-01

In concerts of western classical music the provision of a program note is a widespread practice dating back to the 18th century and still commonly in use. Program notes tend to inform listeners and performers about historical context, composer biographical details, and compositional thinking. However, the scant program note research conducted to date reveals that program notes may not foster understanding or enhance listener enjoyment as previously assumed. In the case of canonic works, performers and listeners may already be familiar with much of the program note information. This is not so in the case of newly composed works, which formed the basis of the exploratory study reported here. This article reports the views of 17 living contemporary composers on their writing of program notes for their own works. In particular, the study sought to understand the intended recipient, role and the content of composer-written program notes. Participating composers identified three main roles for their program notes: to shape a performer's interpretation of the work; to guide, engage or direct the listener and/or performer; and as collaborative mode of communication between the composer, performer, and listener. For some composers, this collaboration was intended to result in "performative listening" in which listeners were actively engaged in bringing each composition to life. This was also described as a form of empathy that results in the co-construction of the musical experience. Overall, composers avoided giving too much personal information and they provided performers with more structural information. However, composers did not agree on whether the same information should be provided to both performers and listeners. Composers' responses problematize the view of a program note as a simple statement from writer to recipient, indicating instead a more complex set of relations at play between composer, performer, listener, and the work itself. These relations are illustrated in a model. There are implications for program note writers and readers, and for educators. Future research might seek to enhance understanding of program notes, including whether the written program note is the most effective format for communications about music.

The Composer’s Program Note for Newly Written Classical Music: Content and Intentions

PubMed Central

Blom, Diana M.; Bennett, Dawn; Stevenson, Ian

2016-01-01

In concerts of western classical music the provision of a program note is a widespread practice dating back to the 18th century and still commonly in use. Program notes tend to inform listeners and performers about historical context, composer biographical details, and compositional thinking. However, the scant program note research conducted to date reveals that program notes may not foster understanding or enhance listener enjoyment as previously assumed. In the case of canonic works, performers and listeners may already be familiar with much of the program note information. This is not so in the case of newly composed works, which formed the basis of the exploratory study reported here. This article reports the views of 17 living contemporary composers on their writing of program notes for their own works. In particular, the study sought to understand the intended recipient, role and the content of composer-written program notes. Participating composers identified three main roles for their program notes: to shape a performer’s interpretation of the work; to guide, engage or direct the listener and/or performer; and as collaborative mode of communication between the composer, performer, and listener. For some composers, this collaboration was intended to result in “performative listening” in which listeners were actively engaged in bringing each composition to life. This was also described as a form of empathy that results in the co-construction of the musical experience. Overall, composers avoided giving too much personal information and they provided performers with more structural information. However, composers did not agree on whether the same information should be provided to both performers and listeners. Composers’ responses problematize the view of a program note as a simple statement from writer to recipient, indicating instead a more complex set of relations at play between composer, performer, listener, and the work itself. These relations are illustrated in a model. There are implications for program note writers and readers, and for educators. Future research might seek to enhance understanding of program notes, including whether the written program note is the most effective format for communications about music. PMID:27881967

Comparative real-time study of cellular uptake of a formulated conjugated linolenic acid rich nano and conventional macro emulsions and their bioactivity in ex vivo models for parenteral applications.

PubMed

Paul, Debjyoti; Mukherjee, Sayani; Chakraborty, Rajarshi; Mallick, Sanjaya K; Dhar, Pubali

2015-02-01

The objective of the present study was to fabricate and monitor real-time, impact of a stable conjugated linolenic acid, α-eleostearic acid (ESA) rich nanoemulsion (NE) formulation (d < 200 nm) vis-à-vis ESA conventional emulsion (CE) system in ex vivo systems against both endogenous and exogenous reactive oxygen species (ROS). Accordingly, stable nanoemulsion formulation of ESA was engineered with the aid of bitter melon seed oil and non-toxic excipients. Morphology and particle size of the emulsion formulations were studied to validate stability. The real-time rapid uptake of the ESA NE and its increased prophylactic efficacy against induced endogenous and exogenous ROS in terms of cell viability and membrane integrity was evaluated flow-cytometrically and with fluorescence microscopic analysis of different primary cells. It was found that the fabricated non-toxic ESA NE had stable parameters (hydrodynamic mean diameter, particle size distribution and zeta potential) for over 12 weeks. Further, ESA NE at a concentration of ∼ 70 μM exhibited maximum efficacy in protecting cells from oxidative damage against both endogenous and exogenous ROS in lymphocytes and hepatocytes as compared to its corresponding presence in the CE formulation. This study provides a real-time empirical evidence on the influence of nano formulation in enhancing bioavailability and antioxidative properties of ESA. Copyright © 2015 Elsevier B.V. All rights reserved.

Interstellar Neutral Helium in the Heliosphere from IBEX Observations. V. Observations in IBEX-Lo ESA Steps 1, 2, and 3

NASA Astrophysics Data System (ADS)

Swaczyna, Paweł; Bzowski, Maciej; Kubiak, Marzena A.; Sokół, Justyna M.; Fuselier, Stephen A.; Galli, André; Heirtzler, David; Kucharek, Harald; McComas, David J.; Möbius, Eberhard; Schwadron, Nathan A.; Wurz, P.

2018-02-01

Direct-sampling observations of interstellar neutral (ISN) He by the Interstellar Boundary Explorer (IBEX) provide valuable insight into the physical state of and processes operating in the interstellar medium ahead of the heliosphere. The ISN He atom signals are observed at the four lowest ESA steps of the IBEX-Lo sensor. The observed signal is a mixture of the primary and secondary components of ISN He and H. Previously, only data from one of the ESA steps have been used. Here, we extend the analysis to data collected in the three lowest ESA steps with the strongest ISN He signal, for the observation seasons 2009–2015. The instrument sensitivity is modeled as a linear function of the atom impact speed onto the sensor’s conversion surface separately for each ESA step of the instrument. We find that the sensitivity increases from lower to higher ESA steps, but within each of the ESA steps it is a decreasing function of the atom impact speed. This result may be influenced by the hydrogen contribution, which was not included in the adopted model, but seems to exist in the signal. We conclude that the currently accepted temperature of ISN He and velocity of the Sun through the interstellar medium do not need a revision, and we sketch a plan of further data analysis aiming at investigating ISN H and a better understanding of the population of ISN He originating in the outer heliosheath.

Predicate Argument Structure Frames for Modeling Information in Operative Notes

PubMed Central

Wang, Yan; Pakhomov, Serguei; Melton, Genevieve B.

2015-01-01

The rich information about surgical procedures contained in operative notes is a valuable data source for improving the clinical evidence base and clinical research. In this study, we propose a set of Predicate Argument Structure (PAS) frames for surgical action verbs to assist in the creation of an information extraction (IE) system to automatically extract details about the techniques, equipment, and operative steps from operative notes. We created PropBank style PAS frames for the 30 top surgical action verbs based on examination of randomly selected sample sentences from 3,000 Laparoscopic Cholecystectomy notes. To assess completeness of the PAS frames to represent usage of same action verbs, we evaluated the PAS frames created on sample sentences from operative notes of 6 other gastrointestinal surgical procedures. Our results showed that the PAS frames created with one type of surgery can successfully denote the usage of the same verbs in operative notes of broader surgical categories. PMID:23920664

Intentional forgetting: note-taking as a naturalistic example.

PubMed

Eskritt, Michelle; Ma, Sierra

2014-02-01

In the present study, we examined whether note-taking as a memory aid may provide a naturalistic example of intentional forgetting. In the first experiment, participants played Concentration, a memory card game in which the identity and location of pairs of cards need to be remembered. Before the game started, half of the participants were allowed to study the cards, and the other half made notes that were then unexpectedly taken away. No significant differences emerged between the two groups for remembering identity information, but the study group remembered significantly more location information than did the note-taking group. In a second experiment, we examined whether note-takers would show signs of proactive interference while playing Concentration repeatedly. The results indicated that they did not. The findings suggest that participants adopted an intentional-forgetting strategy when using notes to store certain types of information.

Extracting important information from Chinese Operation Notes with natural language processing methods.

PubMed

Wang, Hui; Zhang, Weide; Zeng, Qiang; Li, Zuofeng; Feng, Kaiyan; Liu, Lei

2014-04-01

Extracting information from unstructured clinical narratives is valuable for many clinical applications. Although natural Language Processing (NLP) methods have been profoundly studied in electronic medical records (EMR), few studies have explored NLP in extracting information from Chinese clinical narratives. In this study, we report the development and evaluation of extracting tumor-related information from operation notes of hepatic carcinomas which were written in Chinese. Using 86 operation notes manually annotated by physicians as the training set, we explored both rule-based and supervised machine-learning approaches. Evaluating on unseen 29 operation notes, our best approach yielded 69.6% in precision, 58.3% in recall and 63.5% F-score. Copyright © 2014 Elsevier Inc. All rights reserved.

ESA and Television - bringing space to Europe's television viewers

NASA Astrophysics Data System (ADS)

Habfast, Claus

2007-05-01

Getting ESA into the TV news of its Member States is an important element of the Agency's communication strategy. TV news ingages the public in space activities, leading to political support and, ultimately, funding for future programmes. "ESA TV" is a trusted source of space images and stories for Europe's broadcasters. Space is too good a story not to be part of the news.

Starting a European Space Agency Sample Analogue Collection (ESA2C) and Curation Facility for Exploration Missions.

NASA Astrophysics Data System (ADS)

Smith, C. L.; Rumsey, M. S.; Manick, K.; Gill, S.-J.; Mavris, C.; Schroeven-Deceuninck, H.; Duvet, L.

2017-09-01

The ESA2C will support current and future technology development activities that are required for human and robotic exploration of Mars, Phobos, Deimos, C-Type Asteroids and the Moon.The long-term goal of this work is to produce a useful, useable and sustainable resource for engineers and scientists developing technologies for ESA space exploration missions.

Objectivity in subjectivity: do students' self and peer assessments correlate with examiners' subjective and objective assessment in clinical skills? A prospective study.

PubMed

Inayah, A'man Talal; Anwer, Lucman A; Shareef, Mohammad Abrar; Nurhussen, Akram; Alkabbani, Haifa Mazen; Alzahrani, Alhanouf A; Obad, Adam Subait; Zafar, Muhammad; Afsar, Nasir Ali

2017-05-09

The qualitative subjective assessment has been exercised either by self-reflection (self-assessment (SA)) or by an observer (peer assessment (PA)) and is considered to play an important role in students' development. The objectivity of PA and SA by students as well as those by faculty examiners has remained debated. This matters most when it comes to a high-stakes examination. We explored the degree of objectivity in PA, SA, as well as the global rating by examiners being Examiners' Subjective Assessment (ESA) compared with Objective Structured Clinical Examinations (OSCE). Prospective cohort study. Undergraduate medical students at Alfaisal University, Riyadh. All second-year medical students (n=164) of genders, taking a course to learn clinical history taking and general physical examination. A Likert scale questionnaire was distributed among the participants during selected clinical skills sessions. Each student was evaluated randomly by peers (PA) as well as by himself/herself (SA). Two OSCEs were conducted where students were assessed by an examiner objectively as well as subjectively (ESA) for a global rating of confidence and well-preparedness. OSCE-1 had fewer topics and stations, whereas OSCE-2 was terminal and full scale. OSCE-1 (B=0.10) and ESA (B=8.16) predicted OSCE-2 scores. 'No nervousness' in PA (r=0.185, p=0.018) and 'confidence' in SA (r=0.207, p=0.008) correlated with 'confidence' in ESA. In 'well-preparedness', SA correlated with ESA (r=0.234, p=0.003). OSCE-1 and ESA predicted students' performance in the OSCE-2, a high-stakes evaluation, indicating practical 'objectivity' in ESA, whereas SA and PA had minimal predictive role. Certain components of SA and PA correlated with ESA, suggesting partial objectivity given the limited objectiveness of ESA. Such difference in 'qualitative' objectivity probably reflects experience. Thus, subjective assessment can be used with some degree of objectivity for continuous assessment. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Opportunities and the Perception Ofspace Programs in the Developing Countries

NASA Astrophysics Data System (ADS)

Abubakar, B. G.

2006-08-01

Although the space program as a whole is a true reflection of the level of achievement in human history in the field of Science and Technology, but it is also important to note that there are numbers of communities and societies on this earth that are ignorant about this great achievement, hence leading to the continuous diverting of Potential Astronomers, Aerospace Engineers and Astrologist to other disciplines, thereby undermining the development of the space program over time. It was in view of the above that this research was conducted and came up with the under listed Suggestions/Recommendations:- 1. The European Space Agency (ESA), National Aeronautic Space Agency (NASA) and the Russian Space Agency, should be organising and sponsoring public enlightenment conferences, seminars and workshops towards creating awareness and attracting Potential Astronomers and other Space Scientist mostly in the developing countries into the space program. 2. Esteemed organisations in space programs like NASA, ESA and others should be awarding scholarships to potential space scientist that lack the financial capability to pursue studies in the field of space science from the developing countries. 3. The European Space Agency, National Aeronautic Space Agency and the Russian Space Agency, should open their offices for the development of the space program in the third world countries. I believe that if the above suggestions/recommendations are adopted and implemented it will lead to the development of the space program in general, otherwise the rate at which potential Astronomers, Aerospace Engineers and Astrologists will be diverting into other disciplines will ever remain on the increase.

OpportunitiesandPerceptionofSpaceProgramsintheDevelopingCountries

NASA Astrophysics Data System (ADS)

Abubakar, B.

2007-05-01

Although the space program as a whole is a true reflection of the level of achievement in human history in the field of Science and Technology, but it is also important to note that there are numbers of communities and societies on this earth that are ignorant about this great achievement, hence leading to the continuous diverting of Potential Astronomers, Aerospace Engineers and Astrologist to other disciplines, thereby undermining the development of the space program over time. It was in view of the above that this research was conducted and came up with the under listed Suggestions/Recommendations:- (1) The European Space Agency (ESA), National Aeronautic Space Agency (NASA) and the Russian Space Agency, should be organising and sponsoring public enlightenment conferences, seminars and workshops towards creating awareness and attracting Potential Astronomers and other Space Scientist mostly in the developing countries into the space program. (2) Esteemed organisations in space programs like NASA, ESA and others should be awarding scholarships to potential space scientist that lacks the financial capability to pursue studies in the field of space science from the developing countries. (3) The European Space Agency, National Aeronautic Space Agency and the Russian Space Agency, should open their offices for the development of the space program in the third world countries. I believe that if the above suggestions/recommendations are adopted and implemented it will lead to the development of the space program in general, otherwise the rate at which potential Astronomers, Aerospace Engineers and Astrologists will be diverting into other disciplines will ever remain on the increase. Thanks for listening.

Europe creates a workplace in space

NASA Astrophysics Data System (ADS)

Velupillai, D.

1982-05-01

The spacelab pallets, both long and short, and the equipment, operation, and safety features are described, noting that the project was undertaken by joint agreement between NASA and ESA. Fire extinguishers are included which can be controlled from the Orbiter, from which the oxygen supply originates. Spacelab has its own power and temperature control systems and is purely a work area, which makes it necessary for the crew to eat and sleep in the Shuttle cabin. The shell of the module is composed of aluminum alloy panels, and a 25 mm hole caused by a meteorite can be tolerated. Fracture mechanics simulations have contributed to a leak-before-burst philosophy for the safety of the vessel exterior. The large module is 7 m long and 4.06 m in diameter, while the short module is 2.7 m long and the same diameter. An unmanned igloo can also be flown with palleted instruments to provide power, control, and telemetry.

BepiColombo mission to be presented to the media

NASA Astrophysics Data System (ADS)

2008-01-01

After a competitive phase started in 2001, ESA has awarded Astrium the prime contract to build BepiColombo. The contract signature ceremony will take place in presence of the Prime Minister of Baden Württemberg (Germany), Dr. Guenther Oettinger, and will mark the kick-off of the industrial development of the spacecraft. BepiColombo will be launched in 2013. It consists of two spacecraft - an orbiter for planetary investigation, led by ESA, and one for magnetospheric studies, led by the Japan Aerospace Exploration Agency (JAXA). The satellite duo will reach Mercury in 2019 after a six-year journey towards the inner Solar System, to make the most extensive and detailed study of Mercury ever attempted. The press event will feature a thorough presentation of the mission and its objectives, as well as the technical challenges that Astrium will have to address. Such challenges derive from the difficulty of reaching, surviving and operating in the harsh environment of a planet so close to Sun, making of BepiColombo one of the most complex long-term planetary projects undertaken by ESA so far. Media interested to attend are invited to register by the reply form attached below. Visit of Prime Minister Guenther Oettinger and BepiColombo Contract Signature Event programme 18 January 2008, h 10:30 Astrium Friedrichshafen, Germany Claude-Dornier-Straße, 88090 Immenstaad Building 8, Room "Meersburg" 10:30 Check-in 11:00 Welcome and introduction, Uwe Minne, Astrium, Director of Earth Observation and Science, Head of Friedrichshafen Site 11:05 BepiColombo in the context of the ESA Science Programme, Jacques Louet, ESA Head of Science Projects Departments 11:10 BepiColombo's scientific objectives, Johannes Benkhoff, ESA, BepiColombo Project Scientist 11:20 The BepiColombo mission, Jan van Casteren, ESA, BepiColombo Project Manager 11:30 BepiColombo's technical challenges, Rainer Best, Astrium, BepiColombo Project Manager 11:40 Q&A 12:00 Buffet lunch 13:00 Arrival of Prime Minister Guenther Oettinger, welcomed by Evert Dudok, CEO Astrium Satellites, Uwe Minne and Dr. Johannes v. Thadden, Astrium, Head of Political Affairs 13:05 Astrium at Friedrichshafen and its experience and heritage in scientific satellites, Uwe Minne, Head of Friedrichshafen Site 13:15 Astrium in Baden-Württemberg, and the importance of satellite Manufacturing, Evert Dudok, CEO Astrium Satellites 13:25 The ESA Science Programme and Germany’s involvement,David Southwood, ESA Director of Science 13:35 Contract Signature of BepiColombo, D. Southwood, ESA / E. Dudok,Astrium - J. Louet, ESA / U. Minne, Astrium 13:45 Speech of Guenther Oettinger, Prime Minister of Federal State of Baden-Württemberg: “Baden-Württemberg: a high-tech Country” 14:05 Transfer to Satellite Cleanroom 14:10 Visit Satellite Manufacturing 14:30 End of event

The Impact of Novice Counselors' Note-Taking Behavior on Recall and Judgment

ERIC Educational Resources Information Center

Lo, Chu-Ling; Wadsworth, John

2014-01-01

Purpose: To examine the effect of note-taking on novice counselors' recall and judgment of interview information in four situations: no notes, taking notes, taking notes and reviewing these notes, and reviewing notes taken by others. Method: The sample included 13 counselors-in-training recruited from a master's level training program in…

Frequency of reporting and predictive factors for anxiety and depression in patients with advanced cancer.

PubMed

Salvo, N; Zeng, L; Zhang, L; Leung, M; Khan, L; Presutti, R; Nguyen, J; Holden, L; Culleton, S; Chow, E

2012-03-01

The prevalence of anxiety and depression in patients with advanced cancer has been reported to be on average 25% and to significantly affect patients' quality of life. Despite high prevalence rates, these disorders remain underdiagnosed and undertreated. The purpose of our study was to examine the self-report rates of anxiety and depression with the Edmonton Symptom Assessment System (ESAS) and to assess the predictive factors for these reports in cancer patients with metastatic disease. Consecutive patients who attended the Rapid Response Radiotherapy Program (RRRP) completed the ESAS as well as baseline demographic information. Ordinal logistic regression analysis was used to determine factors that significantly predicted anxiety and/or depression. Pearson χ(2) was used to test goodness-of-fit for categorical variables and established whether or not an observed frequency distribution differed from a predicted frequency distribution. A univariate analysis was conducted first and those variables with a P value<0.100 were included in a multivariate analysis. A score test was used to test the proportional odds assumption. In total, 1439 patients seen in the RRRP between January 1999 and October 2009 completed ESAS questionnaires. Fifty-five per cent of patients reported at least mild symptoms of depression and 65% reported at least mild anxiety. In the univariate analysis, patients who were female, who had a lower performance status score, or primary lung cancer were more likely to report depressed and anxious feelings. Primary prostate cancer patients were significantly less likely to report depression and anxiety. Patients referred for spinal cord compression were significantly less depressed. The multivariate models showed that younger patients were significantly more anxious than older patients and females reported more anxiety than males. Patients who reported higher feelings of nausea, tiredness, drowsiness, dyspnoea, and worse appetite and overall well-being on the ESAS tool were more likely to report feelings of depression. Patients who reported higher nausea, drowsiness, dyspnoea and worse overall well-being more often reported higher feelings of anxiety. The self-report rates of anxiety and depression were consistent with published prevalence rates. However, the explained variance based on factors included in the model remains low. Additional predictive factors should be examined in future studies in this population. The ESAS tool seems to be an efficient screening tool for anxiety and depression; however, future studies should examine its correlative properties with other known screening tools in the advanced cancer population. A prospective study should be conducted to assess the severity cut-off point in which the ESAS scores most frequently lead to a further diagnosis of an anxiety or depressive disorder in the advance cancer population. Copyright © 2011 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

Occurrence of alachlor and its sulfonated metabolite in rivers and reservoirs of the midwestern United States: The importance of sulfonation in the transport of chloroacetanilide herbicides

USGS Publications Warehouse

Thurman, E.M.; Goolsby, D.A.; Aga, D.S.; Pomes, M.L.; Meyer, M.T.

1996-01-01

Alachlor and its metabolite, 2-[(2',6'-diethylphenyl)- (methoxymethyl)amino]-2-oxoethanesulfonate (ESA), were identified in 76 reservoirs in the midwestern United States using immunoassay, liquid chromatography, and gas chromatography/mass spectrometry. The median concentration of ESA (0.48 ??g/L) exceeded the median concentration of alachlor (<0.05 ??g/L), with highest values in the upper Midwest. ESA also was detected in the Mississippi River from the mouth to the headwaters at concentrations of 0.2-1.5 ??g/L, exceeding the concentration of alachlor. In a field runoff study, alachlor rapidly formed ESA. It is hypothesized that a glutathione conjugate forms, which later oxidizes in soil to ESA. The removal of the chlorine atom lessens the toxicity of the parent compound and increases runoff potential. It is hypothesized further that sulfonic acid metabolites of other chloroacetanilides, including acetochlor, butachlor, metolachlor, and propachlor, also occur in surface water.

Excretory-secretory antigens: a suitable candidate for immunization against ocular toxoplasmosis in a murine model.

PubMed

Norouzpour Deilami, Kiumars; Daryani, Ahmad; Ahmadpour, Ehsan; Sharif, Mehdi; Dadimoghaddam, Yousef; Sarvi, Shahabeddin; Alizadeh, Ahad

2014-12-01

Toxoplasmosis, responsible for ocular impairment, is caused by Toxoplasma gondii. We investigated the effect of Toxoplasma excretory-secretory antigens (ESA) on parasite load and distribution in the eye tissue of a murine model. Case and control groups were immunized with ESA and PBS, respectively. Two weeks after the second immunization, the mice were challenged intraperitoneally with virulent RH strain of Toxoplasma; eye tissue samples of both groups were collected daily (days 1, 2, 3, and the last day before death). Parasite load was determined using real-time quantitative PCR targeted at the B1 gene. Compared to the control group, infected mice that received ESA vaccine presented a considerable decrease in parasite load in the eye tissue, demonstrating the effect of ESA on parasite load and distribution. Diminution of parasite load in mouse eye tissue indicated that ESA might help control disease-related complications and could be a valuable immunization candidate against ocular toxoplasmosis. Copyright © 2014 Elsevier Ltd. All rights reserved.

Overview of ESA life support activities in preparation of future exploration

NASA Astrophysics Data System (ADS)

Lasseur, Christophe; Paille, Christel

2016-07-01

Since 1987, the European Space Agency has been active in the field of Life Support development. When compare to its international colleagues, it is clear that ESA started activities in the field with a "delay of around 25 years. Due to this situation and to avoid duplication, ESA decided to focus more on long term manned missions and to consider more intensively regenerative technologies as well as the associated risks management ( e.g. physical, chemical and contaminants). Fortunately or not, during the same period, no clear plan of exploration and consequently not specific requirements materialized. This force ESA to keep a broader and generic approach of all technologies. Today with this important catalogue of technologies and know-how, ESA is contemplating the different scenario of manned exploration beyond LEO. In this presentation we review the key scenario of future exploration, and identify the key technologies who loo the more relevant. An more detailed status is presented on the key technologies and their development plan for the future.

The ESA contribution to the European Satellite Navigation Programme

NASA Astrophysics Data System (ADS)

Lucas, R.; Lo Galbo, P.; de Mateo, M. L.; Steciw, A.; Ashford, E.

1996-02-01

This paper describes the ESA ARTES-9 programme on Global Navigation Satellite Systems (GNSS). This programme will be the ESA contribution to the wider European Satellite Navigation Programme which is to be implemented as a joint effort of the European Union, Eurocontrol and ESA with the support of other European bodies such as telecommunication operators, national civil aviation authorities, national space agencies, industry, universities and R&D institutes in general. In fact, in view of the geographical area concerned, the large number of parties interested, the experience required and the global nature of GNSS, the proposed initiative can only be successful if based on a strong cooperation at a European and international scale. The ESA ARTES-9 programme will consist on one side, of the design, development and validation of the European complement to the GPS and GLONASS systems (GNSS1), and on the other side of the study, design and pre-development of the European contribution to follow-on systems: GNSS2.

Evaluation and prioritization of stream habitat monitoring in the Lower Columbia Salmon and Steelhead Recovery Domain as related to the habitat monitoring needs of ESA recovery plans

USGS Publications Warehouse

Puls, Amy L.; Anlauf Dunn, Kara; Graham Hudson, Bernadette

2014-01-01

The lower Columbia River and its tributaries once supported abundant runs of salmon and steelhead; however, there are five species currently listed under the federal Endangered Species Act (ESA). The National Marine Fisheries Service has completed, and is proposing for adoption, a comprehensive ESA Recovery Plan for the Lower Columbia Evolutionarily Significant Units (ESUs) based on the recovery plans developed by Oregon and Washington. One of the primary factors attributed to the decline of these species is habitat degradation. There are numerous entities conducting status and/or trends monitoring of instream habitat in the lower Columbia River Basin, but because the programs were developed for agency specific reasons, the existing monitoring efforts are not well coordinated, and often lack the spatial coverage, certainty, or species coverage necessary to answer questions related to status and trends of the ESA listed populations. The Pacific Northwest Aquatic Monitoring Partnership’s Integrated Status and Trends Monitoring (ISTM) project was initiated to improve integration of existing and new monitoring efforts by developing recommendations for sampling frames, protocols, and data sharing. In an effort to meet the ISTM project goals, five objectives were identified: (1) identify and prioritize decisions, questions, and monitoring objectives, (2) evaluate how existing programs align with these management decisions, questions, and objectives, (3) identify the most appropriate monitoring design to inform priority management decisions, questions, and objectives, (4) use trade-off analysis to develop specific recommendations for monitoring based on outcomes of Objectives 1-3 and (5) recommend implementation and reporting mechanisms. This report summarizes the effort to address Objectives 1 and 2, detailing the commonalities among the habitat characteristics that all entities measure and monitor, and how the metrics align with the priorities listed in the comprehensive recovery plan for the Lower Columbia ESUs.

Swarm: ESA's Magnetic Field Mission

NASA Astrophysics Data System (ADS)

Plank, G.; Floberghagen, R.; Menard, Y.; Haagmans, R.

2013-12-01

Swarm is the fifth Earth Explorer mission in ESA's Living Planet Programme, and is scheduled for launch in fall 2013. The objective of the Swarm mission is to provide the best-ever survey of the geomagnetic field and its temporal evolution using a constellation of three identical satellites. The mission shall deliver data that allow access to new insights into the Earth system by improved scientific understanding of the Earth's interior and near-Earth electromagnetic environment. After launch and triple satellite release at an initial altitude of about 490 km, a pair of the satellites will fly side-by-side with slowly decaying altitude, while the third satellite will be lifted to 530 km to complete the Swarm constellation. High-precision and high-resolution measurements of the strength, direction and variation of the magnetic field, complemented by precise navigation, accelerometer and electric field measurements, will provide the observations required to separate and model various sources of the geomagnetic field and near-Earth current systems. The mission science goals are to provide a unique view into Earth's core dynamics, mantle conductivity, crustal magnetisation, ionospheric and magnetospheric current systems and upper atmosphere dynamics - ranging from understanding the geodynamo to contributing to space weather. The scientific objectives and results from recent scientific studies will be presented. In addition the current status of the project, which is presently in the final stage of the development phase, will be addressed. A consortium of European scientific institutes is developing a distributed processing system to produce geophysical (Level 2) data products for the Swarm user community. The setup of the Swarm ground segment and the contents of the data products will be addressed. In case the Swarm satellites are already in orbit, a summary of the on-going mission operations activities will be given. More information on Swarm can be found at www.esa.int/esaLP/LPswarm.html.

Factors Affecting Hemodialysis Adequacy in Cohort of Iranian Patient with End Stage Renal Disease.

PubMed

Shahdadi, Hosein; Balouchi, Abbas; Sepehri, Zahra; Rafiemanesh, Hosein; Magbri, Awad; Keikhaie, Fereshteh; Shahakzehi, Ahmad; Sarjou, Azizullah Arbabi

2016-08-01

There are many factors that can affect dialysis adequacy; such as the type of vascular access, filter type, device used, and the dose, and rout of erythropoietin stimulation agents (ESA) used. The aim of this study was investigating factors affecting Hemodialysis adequacy in cohort of Iranian patient with end stage renal disease (ESRD). This is a cross-sectional study conducted on 133 Hemodialysis patients referred to two dialysis units in Sistan-Baluchistan province in the cities of Zabol and Iranshahr, Iran. We have looked at, (the effects of the type of vascular access, the filter type, the device used, and the dose, route of delivery, and the type of ESA used) on Hemodialysis adequacy. Dialysis adequacy was calculated using kt/v formula, two-part information questionnaire including demographic data which also including access type, filter type, device used for hemodialysis (HD), type of Eprex injection, route of administration, blood groups and hemoglobin response to ESA were utilized. The data was analyzed using the SPSS v16 statistical software. Descriptive statistical methods, Mann-Whitney statistical test, and multiple regressions were used when applicable. The range of calculated dialysis adequacy is 0.28 to 2.39 (units of adequacy of dialysis). 76.7% of patients are being dialyzed via AVF and 23.3% of patients used central venous catheters (CVC). There was no statistical significant difference between dialysis adequacy, vascular access type, device used for HD (Fresenius and B. Braun), and the filter used for HD (p> 0.05). However, a significant difference was observed between the adequacy of dialysis and Eprex injection and patients' time of dialysis (p <0.05). Subcutaneous ESA (Eprex) injection and dialysis shift (being dialyzed in the morning) can have positive impact on dialysis adequacy. Patients should be educated on the facts that the type of device used for HD and the vascular access used has no significant effects on dialysis adequacy.

Earth Sciences data access and preservation with gLibrary

NASA Astrophysics Data System (ADS)

Guidetti, Veronica; Calanducci, Antonio

2010-05-01

ESA-ESRIN, the European Space Agency Centre for Earth Observation (EO), is the largest European EO data provider and operates as the reference European centre for EO payload data exploitation. EO data acquired from space have become powerful scientific tools to enable better understanding and management of the Earth and its resources. Large international initiatives such as GMES and GEO, supported by the European Commission, focus on coordinating international efforts to environmental monitoring, i.e. to provide political and technical solutions to global issues, such as climate change, global environment monitoring, management of natural resources and humanitarian response. Since the time-span of EO data archives extends from a few years to decades, their value as scientific time-series increases considerably, especially for the topic of global change. It will be soon necessary to re-analyse on global scale the information currently locked inside large thematic archives. Future research in the field of Earth Sciences is of invaluable importance: to carry it on researchers worldwide must be enabled to find and access data of interest in a quick and easy way. At present, several thousands of scientists, principal investigators and operators, access EO missions' metadata, data and derived information on a daily basis. Main objectives may be to study the global climate change, to check the status of the instrument on-board and the quality of EO data. There is a huge worldwide scientific community calling for the need to keep EO data accessible without time constrains, easily and quickly. In collaboration with ESA-ESRIN, INFN, the National Institute for Nuclear Physics, is implementing a demonstrative use case where satellite remote sensing data, including in-situ data and other kind of digital assets, are made available to the scientific community via gLibrary (https://glibrary.ct.infn.it), the INFN digital library platform. gLibrary can be used to store, organise, browse, retrieve, annotate and replicate any kind of digital asset on data grids or distributed storage environments. It provides digital assets preservation capabilities, making use of distributed replication of assets, decoupling from the underlying storage technology, and adoption of standard interfaces and metadata descriptions. In its future development gLibrary will investigate and possibly provide integration with grid and HPC processing services, including the ESA G-POD facility (http://eogrid.esrin.esa.int). Currently, gLibrary features encompass fast data access, quick retrieval of digital assets, metadata handling and sharing (including text annotation), high availability and scalability (due to its distributed architecture), (meta)data replication and, last but not least, authentication and authorisation. Much of the experimentation is on-going at EC and international level to provide coordinated and interoperable access to EO data and satellite imagery including any kind of related digital assets (metadata, documents, product guidelines, auxiliary data, mission/sensor specifications, environmental reports). The work with gLibrary comes as a best effort initiative and targets a full interoperability with ESA EO data dissemination, recovering and processing services and intends to demonstrate the benefit the scientific community can gain from this kind of integrated data access. It contributes to respond to the Earth Sciences data users' needs, moving forward the technology development to facilitate a very interactive EO information sharing, analysis and interoperability on the Web.

Posttest analysis of LOFT LOCE L2-3 using the ESA RELAP4 blowdown model. [PWR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perryman, J.L.; Samuels, T.K.; Cooper, C.H.

A posttest analysis of the blowdown portion of Loss-of-Coolant Experiment (LOCE) L2-3, which was conducted in the Loss-of-Fluid Test (LOFT) facility, was performed using the experiment safety analysis (ESA) RELAP4/MOD5 computer model. Measured experimental parameters were compared with the calculations in order to assess the conservatisms in the ESA RELAP4/MOD5 model.

Portrait view of ESA Spacelab Specialists

NASA Technical Reports Server (NTRS)

1978-01-01

Portrait view of European Space Agency (ESA) Spacelab Specialist Byron K. Lichtenberg in civilian clothes standing in front of a display case. The photo was taken at the Marshall Space Flight Center (MSFC), Huntsville, Alabama (31779); portrait view of ESA Spacelab Specialist Michael L. Lampton, also in civilian clothes in front of display at MSFC (31780); portrait view of Wubbo Ockels, also in civilian clothes in front of display at MSFC (31781).

EOforge: Generic Open Framework for Earth Observation Data Processing Systems

DTIC Science & Technology

2006-09-01

Allow the use of existing interfaces, i.e. MUIS: ESA multimission catalogue for EO products. • Support last EO systems technologies, i.e. MASS ...5. Extensibility and configurability to allow customisation and the inclusion of new functionality. 6. Multi-instrument and multi-mission processing...such as: • MUIS: ESA multimission catalogue for EO products. • MASS (Multi-Application Support Service System): ESA web services technology standard

The definition of ESA's scientific programme for the 1980's.

NASA Astrophysics Data System (ADS)

Russo, A.

1997-09-01

The following topics were dealt with: discussing a long-term strategy for ESA's scientific activities; the SAC's (Science Advisory Committee) vision of European space science in the 1980s; the role of Spacelab (and Ariane); more money for science?; studying future scientific projects (the comets and the Moon); the selection of ESA's next scientific mission (the comet and the stars, the SPC decision, Giotto and Hipparcos adopted).

Toward a patient-centered ambulatory after-visit summary: Identifying primary care patients' information needs.

PubMed

Clarke, Martina A; Moore, Joi L; Steege, Linsey M; Koopman, Richelle J; Belden, Jeffery L; Canfield, Shannon M; Kim, Min S

2018-09-01

The purpose of this study was to determine the information needs of primary care patients as they review clinic visit notes to inform information that should be contained in an after-visit summary (AVS). We collected data from 15 patients with an acute illness and 14 patients with a chronic disease using semi-structured interviews. The acute patients reviewed seven major sections, and chronic patients reviewed eight major sections of a simulated, but realistic visit note to identify relevant information needs for their AVS. Patients in the acute illness group identified the Plan, Assessment and History of Present Illness the most as important note sections, while patients in the chronic care group identified Significant Lab Data, Plan, and Assessment the most as important note sections. This study was able to identify primary care patients' information needs after clinic visit. Primary care patients have information needs pertaining to diagnosis and treatment, which may be the reason why both patient groups identified Plan and Assessment as important note sections. Future research should also develop and assess an AVS based on the information gathered in this study and evaluate its usefulness among primary care patients. The results of this study can be used to inform the development of an after-visit summary that assists patients to fully understand their treatment plan, which may improve treatment adherence.

First Light for ASTROVIRTEL Project

NASA Astrophysics Data System (ADS)

2000-04-01

Astronomical data archives increasingly resemble virtual gold mines of information. A new project, known as ASTROVIRTEL aims to exploit these astronomical treasure troves by allowing scientists to use the archives as virtual telescopes. The competition for observing time on large space- and ground-based observatories such as the ESA/NASA Hubble Space Telescope and the ESO Very Large Telescope (VLT) is intense. On average, less than a quarter of applications for observing time are successful. The fortunate scientist who obtains observing time usually has one year of so-called proprietary time to work with the data before they are made publicly accessible and can be used by other astronomers. Precious data from these large research facilities retain their value far beyond their first birthday and may still be useful decades after they were first collected. The enormous quantity of valuable astronomical data now stored in the archives of the European Southern Observatory (ESO) and the Space Telescope-European Coordinating Facility (ST-ECF) is increasingly attracting the attention of astronomers. Scientists are aware that one set of observations can serve many different scientific purposes, including some that were not considered at all when the observations were first made. Data archives as "gold mines" for research [ASTROVIRTEL Logo; JPEG - 184 k] Astronomical data archives increasingly resemble virtual gold mines of information. A new project, known as ASTROVIRTEL or "Accessing Astronomical Archives as Virtual Telescopes" aims to exploit these astronomical treasure troves. It is supported by the European Commission (EC) within the "Access to Research Infrastructures" action under the "Improving Human Potential & the Socio-economic Knowledge Base" of the EC (under EU Fifth Framework Programme). ASTROVIRTEL has been established on behalf of the European Space Agency (ESA) and the European Southern Observatory (ESO) in response to rapid developments currently taking place in the fields of telescope and detector construction, computer hardware, data processing, archiving, and telescope operation. Nowadays astronomical telescopes can image increasingly large areas of the sky. They use more and more different instruments and are equipped with ever-larger detectors. The quantity of astronomical data collected is rising dramatically, generating a corresponding increase in potentially interesting research projects. These large collections of valuable data have led to the useful concept of "data mining", whereby large astronomical databases are exploited to support original research. However, it has become obvious that scientists need additional support to cope efficiently with the massive amounts of data available and so to exploit the true potential of the databases. The strengths of ASTROVIRTEL ASTROVIRTEL is the first virtual astronomical telescope dedicated to data mining. It is currently being established at the joint ESO/Space Telescope-European Coordinating Facility Archive in Garching (Germany). Scientists from EC member countries and associated states will be able to apply for support for a scientific project based on access to and analysis of data from the Hubble Space Telescope (HST), Very Large Telescope (VLT), New Technology Telescope (NTT), and Wide Field Imager (WFI) archives, as well as a number of other related archives, including the Infrared Space Observatory (ISO) archive. Scientists will be able to visit the archive site and collaborate with the archive specialists there. Special software tools that incorporate advanced methods for exploring the enormous quantities of information available will be developed. Statements The project co-ordinator, Piero Benvenuti , Head of ST-ECF, elaborates on the advantages of ASTROVIRTEL: "The observations by the ESA/NASA Hubble Space Telescope and, more recently, by the ESO Very Large Telescope, have already been made available on-line to the astronomical community, once the proprietary period of one year has elapsed. ASTROVIRTEL is different, in that astronomers are now invited to regard the archive as an "observatory" in its own right: a facility that, when properly used, may provide an answer to their specific scientific questions. The architecture of the archives as well as their suite of software tools may have to evolve to respond to the new demand. ASTROVIRTEL will try to drive this evolution on the basis of the scientific needs of its users." Peter Quinn , the Head of ESO's Data Management and Operations Division, is of the same opinion: "The ESO/HST Archive Facility at ESO Headquarters in Garching is currently the most rapidly growing astronomical archive resource in the world. This archive is projected to contain more than 100 Terabytes (100,000,000,000,000 bytes) of data within the next four years. The software and hardware technologies for the archive will be jointly developed and operated by ESA and ESO staff and will be common to both HST and ESO data archives. The ASTROVIRTEL project will provide us with real examples of scientific research programs that will push the capabilities of the archive and allow us to identify and develop new software tools for data mining. The growing archive facility will provide the European astronomical community with new digital windows on the Universe." Note [1] This is a joint Press Release by the European Southern Observatory (ESO) and the Space Telescope European Coordinating Facility (ST-ECF). Additional information More information about ASTROVIRTEL can be found at the dedicated website at: http://www.stecf.org/astrovirtel The European Southern Observatory (ESO) is an intergovernmental organisation, supported by eight European countries: Belgium, Denmark, France, Germany, Italy, The Netherlands, Sweden and Switzerland. The European Space Agency is an intergovernmental organisation supported by 15 European countries: Austria, Belgium, Denmark, Finland, France, Germany, Ireland, Italy, Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom. The Space Telescope European Coordinating Facility (ST-ECF) is a co-operation between the European Space Agency and the European Southern Observatory. The Hubble Space Telescope (HST) is a project of international co-operation between NASA and ESA.

The topography of a continental indenter: The interplay between crustal deformation, erosion, and base level changes in the eastern Southern Alps.

PubMed

Robl, J; Heberer, B; Prasicek, G; Neubauer, F; Hergarten, S

2017-01-01

The topography of the eastern Southern Alps (ESA) reflects indenter tectonics causing crustal shortening, surface uplift, and erosional response. Fluvial drainages were perturbed by Pleistocene glaciations that locally excavated alpine valleys. The Late Miocene desiccation of the Mediterranean Sea and the uplift of the northern Molasse Basin led to significant base level changes in the far field of the ESA and the Eastern Alps (EA), respectively. Among this multitude of mechanisms, the processes that dominate the current topographic evolution of the ESA and the ESA-EA drainage divide have not been identified. We demonstrate the expected topographic effects of each mechanism in a one-dimensional model and compare them with observed channel metrics. We find that the normalized steepness index increases with uplift rate and declines from the indenter tip in the northwest to the foreland basin in the southeast. The number and amplitude of knickpoints and the distortion in longitudinal channel profiles similarly decrease toward the east. Changes in slope of χ -transformed channel profiles coincide spatially with the Valsugana-Fella fault linking crustal stacking and uplift induced by indenter tectonics with topographic evolution. Gradients in χ across the ESA-EA drainage divide imply an ongoing, north directed shift of the Danube-ESA watershed that is most likely driven by a base level rise in the northern Molasse basin. We conclude that the regional uplift pattern controls the geometry of ESA-EA channels, while base level changes in the far field control the overall architecture of the orogen by drainage divide migration.

ESA's experts are ready for a storm of comet dust

NASA Astrophysics Data System (ADS)

1998-11-01

Minute grains of dust create the glowing heads and tails that make comets famous. A trail of dust traces the orbit of each comet, and when the Earth encounters a comet trail the result is a meteor shower. Comet Tempel-Tuttle has just refreshed its dust trail on a visit to the Sun's vicinity, which it makes every 33 years. The Leonids approach the Earth from the direction of the constellation Leo. As a precaution, the Hubble Space Telescope will turn its back on Leo for ten hours around the predicted peak of the Leonid event, which is at about 20:30 CET on 17 November. Astronomers will take the opportunity to look for undiscovered galaxies in the opposite direction in the sky. Any disturbances caused to the 11.6-tonne Hubble spacecraft by the Leonid dust impacts will be recorded for analysis by dust specialists. One of the teams chosen for this study includes ESA and UK scientists and is headed by John Zarnecki of the University of Kent. Zarnecki comments: "It seems like doing an experiment with the crown jewels. But Hubble is a fantastically accurate star pointer, so we should detect wobbles due to quite small impacts. We hope to check our theories about the numbers of grains of different masses. But I'd hate to see any harm come to Hubble," Zarnecki adds. "Or any other spacecraft for that matter." Taking account of the risk to spacecraft This year Comet Tempel-Tuttle passed within 1.2 million kilometres of the Earth's orbit, which is very near by astronomical standards. Similar close encounters have produced widely differing results in the past. In 1932 the count of visible meteors in the Leonids reached an unremarkable rate of 240 per hour, compared with a normal background of about 10-20 sporadic meteors per hour at quiet times. Yet in 1966 the count-rate for the Leonids was 15,000 per hour, or 4 per second, and some observers reported even higher rates. If the rate is again 15,000 per hour, a spacecraft presenting a target of 10 square metres to the Leonid storm is likely to receive one hit penetrating aluminium to a depth of 0.4 millimetre. A larger spacecraft has a greater chance of being hit by a more penetrating dust grain. Operators are therefore advised to turn their spacecraft to present as small a target as possible, and to try to ensure that sensitive parts do not face the meteor stream. "Bullet-like damage caused by large particles is only part of the story," says Walter Flury of ESOC's mission analysis section. "Fine grains are far more numerous and can sand-blast optical systems, thermal blankets and solar cells. And in a cloud of charged particles created by the impacts, lightning-like discharges can cause faults in the electronic systems of the spacecraft. The very high speed of the Leonids aggravates that risk, so it may be advisable to switch off sensitive equipment. Damage due to electrical discharges may be the most serious hazard from the Leonids." Predictions are very uncertain and effects are very chancy, so one recommendation is simply to reinforce the spacecraft operation teams on 17 November, to cope with any emergency that arises. The direction of arrival of the Leonids is favourable for satellites in one respect. The dust grains will come from a direction almost at right angles to the direction of the Sun. Flat solar panels in their normal orientation, facing the Sun, present only a narrow edge as a target for the Leonids. Controllers of ESA's Earth observation satellites ERS-1 and ERS-2 will switch off the instruments during the hazardous period to reduce the risk of electrically-induced damage. ESA's solar spacecraft SOHO, stationed 1.5 million kilometres out in space, is likely to experience an even stronger storm of Leonids than satellites in the Earth's vicinity. Measures to reduce the hazard may include rotating the spacecraft to screen vital equipment, and switching off scientific instruments. The view from the ground When the Leonids are at their peak, Leo will just be rising on Europe's eastern horizon. Nevertheless, observers in Europe watching out between midnight and dawn, on 17 and 18 November, may see unusual numbers of meteors. The best view will be from east Asia, where Leo will be high in the night sky at the time of the expected maximum. ESA has joined with other space agencies in sponsoring a Canadian expedition to Mongolia to observe the Leonids with video cameras equipped with image intensifiers. The same Canadian intiative will use radars in northern Australia to detect the meteors. Real-time information on the intensity and duration of the dust storm will help spacecraft operators to judge when the risk has passed. Next year's appearance of the Leonids, in November 1999, will be best seen from Europe, and it could be bigger than this year's event. For the same reason, the risk posed by the Leonids to spacecraft will recur at that time. ESA scientists will be rehearsing this year for ground-based observations of the Leonids next year, from southern Spain. Historical note on dust damage ESA has brutal experience of cosmic dust storms. In March 1986, its Giotto spacecraft flew deep into the dusty head of Halley's Comet, where it obtained amazing pictures of the nucleus. A dust particle no bigger than a grain of rice slammed into the spacecraft at 68 kilometres per second with the force of a hand grenade, and set it wobbling. A sand-blast of smaller grains, recorded as a continous drumbeat by dust detectors on Giotto, disabled the camera and caused other damage. Nevertheless the ESA operations team recovered control of the spacecraft and even managed to fly Giotto on an extended mission that took it to Comet Grigg-Skjellerup six years later. Controllers were less lucky in August 1993 when a dust grain from Comet Swift-Tuttle, in the Perseid meteor stream, was probably to blame for knocking out ESA's Olympus telecommunications satellite after four years of operation. Although it remained intact, Olympus lost so much thruster fuel in trying to correct its attitude that it became unmanageable. More direct knowledge of dust impacts on spacecraft came from examining part of the original solar array of the Hubble Space Telecope, provided by ESA, which was returned to Earth in the first refurbishment mission in December 1993. The solar cells were pitted by many small dust impacts.

Herbicide concentrations in the Mississippi River Basin - The importance of chloroacetanilide herbicide degradates

USGS Publications Warehouse

Rebich, R.A.; Coupe, R.H.; Thurman, E.M.

2004-01-01

The proportion of chloroacetanilide herbicide degradates, specifically the ethane sulfonic (ESA) and oxanilic (OA) acids, averaged 70% of the total herbicide concentration in samples from the Upper Mississippi River. In samples from the Missouri River and the Ohio River, the proportion of chloroacetanilide degradates in the total herbicide concentration was much less, 24% and 41%, respectively. The amount of tile drainage throughout the Mississippi River Basin appeared to be related to the occurrence and distribution of chloroacetanilide degradates in water samples. Pesticide concentrations in streams of the Mississippi River Basin have been well characterized. However, recent research demonstrates that in order to more fully understand the fate and transport of pesticides, the major pesticide degradates need to be included in the analysis. From March 1999 through May 2001, water samples from four major junctures of the Mississippi River Basin were collected and analyzed for a suite of herbicides and their degradate compounds. Each sampling site was selected to represent a major part of the Mississippi River: upper and lower Mississippi, Missouri and Ohio Rivers. Each basin has unique landscape variables, geology, hydrology, precipitation, and land use, which is reflected in the pesticide content at the most downstream sample site near the mouth of the Mississippi River. Atrazine was the most frequently detected herbicide (detected in 97% of the samples), followed by metolachlor (60%), and acetochlor (31%). The most frequently detected degradates were metolachlor ESA (69%), followed by deethylatrazine (62%), metolachlor OA (37%), and alachlor ESA (37%). Metolachlor ESA was detected more frequently than its parent compound (69 vs. 60%), as was alachlor ESA (37 vs. 9%). After an improvement was made in the analytical method, metolachlor ESA was detected in every sample, metolachlor OA in 89% of the samples, alachlor ESA in 84%, acetochlor ESA in 71%, and acetochlor OA in 66%. ?? 2003 Elsevier B.V. All rights reserved.

Estimating effects of tidal power projects and climate change on threatened and endangered marine species and their food web.

PubMed

Busch, D Shallin; Greene, Correigh M; Good, Thomas P

2013-12-01

Marine hydrokinetic power projects will operate as marine environments change in response to increased atmospheric carbon dioxide concentrations. We considered how tidal power development and stressors resulting from climate change may affect Puget Sound species listed under the U.S. Endangered Species Act (ESA) and their food web. We used risk tables to assess the singular and combined effects of tidal power development and climate change. Tidal power development and climate change posed risks to ESA-listed species, and risk increased with incorporation of the effects of these stressors on predators and prey of ESA-listed species. In contrast, results of a model of strikes on ESA-listed species from turbine blades suggested that few ESA-listed species are likely to be killed by a commercial-scale tidal turbine array. We applied scenarios to a food web model of Puget Sound to explore the effects of tidal power and climate change on ESA-listed species using more quantitative analytical techniques. To simulate development of tidal power, we applied results of the blade strike model. To simulate environmental changes over the next 50 years, we applied scenarios of change in primary production, plankton community structure, dissolved oxygen, ocean acidification, and freshwater flooding events. No effects of tidal power development on ESA-listed species were detected from the food web model output, but the effects of climate change on them and other members of the food web were large. Our analyses exemplify how natural resource managers might assess environmental effects of marine technologies in ways that explicitly incorporate climate change and consider multiple ESA-listed species in the context of their ecological community. Estimación de los Efectos de Proyectos de Energía de las Mareas y el Cambio Climático sobre Especies Marinas Amenazadas y en Peligro y su Red Alimentaria. © 2013 Society for Conservation Biology No claim to original US government works.

Outcomes in patients with chronic kidney disease not on dialysis receiving extended dosing regimens of darbepoetin alfa: long-term results of the EXTEND observational cohort study

PubMed Central

Galle, Jan-Christoph; Addison, Janet; Suranyi, Michael G.; Claes, Kathleen; Di Giulio, Salvatore; Guerin, Alain; Herlitz, Hans; Kiss, István; Farouk, Mourad; Manamley, Nick; Wirnsberger, Gerhard; Winearls, Christopher

2016-01-01

Background Extended dosing of the erythropoiesis-stimulating agent (ESA) darbepoetin alfa (DA) once biweekly or monthly reduces anaemia treatment burden. This observational study assessed outcomes and dosing patterns in patients with chronic kidney disease not on dialysis (CKD-NoD) commencing extended dosing of DA. Methods Adult CKD-NoD patients starting extended dosing of DA in Europe or Australia in June 2006 or later were followed up until December 2012. Outcomes included haemoglobin (Hb) concentration, ESA dosing, mortality rates and receipt of dialysis and renal transplantation. Subgroup analyses were conducted for selected outcomes. Results Of 6035 enrolled subjects, 5723 (94.8%) met analysis criteria; 1795 (29.7%) received dialysis and 238 (3.9%) underwent renal transplantation. Mean (standard deviation) Hb concentration at commencement of extended dosing was 11.0 (1.5) g/dL. Mean [95% confidence interval (CI)] Hb 12 months after commencement of extended dosing (primary outcome) was 11.6 g/dL (11.5, 11.6) overall and was similar across countries, with no differences between subjects previously treated with an ESA versus ESA-naïve subjects, subjects with versus without prior renal transplant or diabetics versus non-diabetics. Weekly ESA dose gradually decreased following commencement of extended DA dosing and was similar across subgroups. The decrease in weekly DA dose was accompanied by an increase in the proportion of patients receiving iron therapy. Hb concentrations declined following changes in ESA labels and treatment guidelines. The mortality rate (95% CI) was 7.06 (6.68, 7.46) deaths per 100 years of follow-up. Subjects alive at study end had stable Hb concentrations in the preceding year, while those who died had lower and declining Hb concentrations in their last year. Conclusions Long-term, extended dosing of DA maintained Hb concentrations in patients already treated with an ESA and corrected and maintained Hb in ESA-naïve patients. PMID:27190334

Metolachlor and its metabolites in tile drain and stream runoff in the canajoharie creek watershed

USGS Publications Warehouse

Phillips, P.J.; Wall, G.R.; Thurman, E.M.; Eckhardt, D.A.; Vanhoesen, J.

1999-01-01

Water samples collected during April-November 1997 from tile drains beneath cultivated fields in central New York indicate that two metabolites of the herbicide metolachlor-metolachlor ESA (ethanesulfonic acid) and OA (oxanilic acid) can persist in agricultural soils for 4 or more years after application and that fine-grained soils favor the transport of metolachlor ESA over metolachlor and metolachlor OA. Concentrations of metolachlor ESA from the tile drains ranged from 3.27 to 23.4 ??g/L (200 1800 times higher than those of metolachlor), metolachlor OA concentrations ranged from 1.14 to 13.5 ??g/L, and metolachlor concentrations ranged from less than 0.01 to 0.1 ??g/L. In the receiving stream, concentrations of metolachlor ESA were always below 0.6 ??g/L except during a November storm, when concentrations reached 0.85 ??g/L. Concentrations of metolachlor ESA in the stream were 2 45 times higher than those of metolachlor, reflecting the greater relative concentrations of metolachlor in surface water runoff than in tile drain runoff. These results are consistent with findings in other studies that acetanilide herbicide degredates are found in much higher concentrations than parent compounds in both surface water and groundwater.Water samples collected during April-November 1997 from tile drains beneath cultivated fields in central New York indicate that two metabolites of the herbicide metolachlor-metolachlor ESA (ethanesulfonic acid) and OA (oxanilic acid)-can persist in agricultural soils for 4 or more years after application and that fine-grained soils favor the transport of metolachlor ESA over metolachlor and metolachlor OA. Concentrations of metolachlor ESA from the tile drains ranged from 3.27 to 23.4 ??g/L (200-1800 times higher than those of metolachlor), metolachlor OA concentrations ranged from 1.14 to 13.5 ??g/L, and metolachlor concentrations ranged from less than 0.01 to 0.1 ??g/L. In the receiving stream, concentrations of metolachlor ESA were always below 0.6 ??g/L except during a November storm, when concentrations reached 0.85 ??g/L. Concentrations of metolachlor ESA in the stream were 2-45 times higher than those of metolachlor, reflecting the greater relative concentrations of metolachlor in surface water runoff than in tile drain runoff. These results are consistent with findings in other studies that acetanilide herbicide degredates are found in much higher concentrations than parent compounds in both surface water and groundwater.

DigiMemo: Facilitating the Note Taking Process

ERIC Educational Resources Information Center

Kurt, Serhat

2009-01-01

Everyone takes notes daily for various reasons. Note taking is very popular in school settings and generally recognized as an effective learning strategy. Further, note taking is a complex process because it requires understanding, selection of information and writing. Some new technological tools may facilitate the note taking process. Among such…

The role of handouts, note-taking and overhead transparencies in veterinary science lectures.

PubMed

McLennan, M W; Isaacs, G

2002-10-01

To study student and staff views of the role and use of handouts, note-taking and overhead transparencies in veterinary science lectures at the University of Queensland The Nominal Group Technique was used to help develop a questionnaire, which was completed by 351 students (a response rate of 84%) and 35 staff (76%) from the 5 years of the veterinary course. The data were analysed using the SAS statistical computer package. Staff and students held different views as to the frequency with which handouts should be used, their educational value, and whether they should be complete or partial. Fewer students than staff agreed that handouts discourage further reading in a subject. Almost all staff and students saw the central functions of note-taking to be provision of notes for subsequent revision and encoding information given by the lecturer. More students than staff however, considered that note-taking in lectures interferes with understanding. Staff and students held similar views as to the uses of overheads in lectures. Interestingly however, more staff than students agreed that overheads often contain too much information. Both students and staff saw the central role of note-taking as providing a set of good notes for revision. Generally students preferred that this information be provided in the form of partial or complete handouts, while staff preferred students to take notes and to read outside lectures. Surprisingly, more staff than students felt that overhead transparencies often contained too much information. Note-taking, handouts and overhead transparencies need to be linked in a coherent educational strategy to promote effective learning.

Evaluation of a user guidance reminder to improve the quality of electronic prescription messages.

PubMed

Dhavle, A A; Corley, S T; Rupp, M T; Ruiz, J; Smith, J; Gill, R; Sow, M

2014-01-01

Prescribers' inappropriate use of the free-text Notes field in new electronic prescriptions can create confusion and workflow disruptions at receiving pharmacies that often necessitates contact with prescribers for clarification. The inclusion of inappropriate patient direction (Sig) information in the Notes field is particularly problematic. We evaluated the effect of a targeted watermark, an embedded overlay, reminder statement in the Notes field of an EHR-based e-prescribing application on the incidence of inappropriate patient directions (Sig) in the Notes field. E-prescriptions issued by the same exact cohort of 97 prescribers were collected over three time periods: baseline, three months after implementation of the reminder, and 15 months post implementation. Three certified and experienced pharmacy technicians independently reviewed all e-prescriptions for inappropriate Sig-related information in the Notes field. A physician reviewer served as the final adjudicator for e-prescriptions where the three reviewers could not reach a consensus. ANOVA and post hoc Tukey HSD tests were performed on group comparisons where statistical significance was evaluated at p<0.05. The incidence of inappropriate Sig-related information in the Notes field decreased from a baseline of 2.8% to 1.8% three months post-implementation and remained stable after 15 months. In addition, prescribers' use of the Notes decreased by 22% after 3 months and had stabilized at 18.7% below baseline after 15 months. Insertion of a targeted watermark reminder statement in the Notes field of an e-prescribing application significantly reduced the incidence of inappropriate Sig-related information in Notes and decreased prescribers' use of this field.

The ENVISAT Atmospheric Chemistry mission (GOMOS, MIPAS and SCIAMACHY) -Processing status and data availability

NASA Astrophysics Data System (ADS)

Dehn, Angelika; Brizzi, G.; Barrot, G.; Bovensmann, H.; Canela, M.; Fehr, T.; Laur, H.; Lichtenberg, G.; Niro, F.; Perron, G.; Raspollini, P.; Saavedra de Miguel, L.; Scarpino, G.; Vogel, P.

The atmospheric chemistry instruments on board the ENVISAT platform (GOMOS, MIPAS and SCIAMACHY) provide a unique dataset of geophysical parameters (e.g.: trace gases, clouds, and aerosol) that allows a comprehensive characterization of the atmosphere's chemical and climatological processes [1]. These instruments started to provide significant science data shortly after the launch of the ENVISAT satellite (March 2002). At the time of writing this paper, these instruments and the whole payload modules are fully working and are well beyond the expected lifetime of 5 years. In addition the orbit control strategy of the platform will be modified starting from 2010, in order to extend the mission lifetime up to 2013 [2]. This means that if no instrument problems will appear, the ENVISAT atmospheric sensors will provide at the end of their life, three separated, but complementary datasets of the most important atmospheric state parameters, spanning a time interval of about 11 years. This represents an extraordinary source of information for the scientific user community, both for the completeness and quality of the data and for the extent of the dataset. The aim of this paper is to present the actual status of the ESA operational atmospheric chemistry dataset provided by the three ENVISAT atmospheric chemistry instruments and the future evolution. The processing and reprocessing status will be described in details for each instrument. The outcomes of the geophysical validation and the planned validation activities will be discussed. Finally the data availability and the source of information will be specified. [1] H. Nett, J. Frerick, T. Paulsen, and G. Levrini, "The atmospheric instruments and their applications: GOMOS, MIPAS and SCIAMACHY", ESA Bulletin (ISSN 0376-4265), No. 106, p. 77 -87 (2001) [2] J. Frerick, B. Duesmann, and M. Canela, "2010 and beyond -The ENVISAT mission extension", Proc. `Envisat Symposium 2007', Montreux, Switzerland, 23-27 April 2007 (ESA SP-636, July 2007)

The ENVISAT Atmospheric Chemistry mission (GOMOS, MIPAS and SCIAMACHY) - Processing status and data availability

NASA Astrophysics Data System (ADS)

Niro, F.

2009-04-01

The atmospheric chemistry instruments on board the ENVISAT platform (GOMOS, MIPAS and SCIAMACHY) provide a unique dataset of geophysical parameters (e.g.: trace gases, clouds, and aerosol) that allows a comprehensive characterization of the atmosphere's chemical and climatological processes [1]. These instruments started to provide significant science data shortly after the launch of the ENVISAT satellite (March 2002). At the time of writing this paper, these instruments and the whole payload modules are fully working and are well beyond the expected lifetime of 5 years. In addition the orbit control strategy of the platform will be modified starting from 2010, in order to extend the mission lifetime up to 2013 [2]. This means that if no instrument problems will appear, the ENVISAT atmospheric sensors will provide at the end of their life, three separated, but complementary datasets of the most important atmospheric state parameters, spanning a time interval of about 11 years. This represents an extraordinary source of information for the scientific user community, both for the completeness and quality of the data and for the extent of the dataset. The aim of this paper is to present the actual status of the ESA operational atmospheric chemistry dataset provided by the three ENVISAT atmospheric chemistry instruments and the future evolution. The processing and reprocessing status will be described in details for each instrument. The outcomes of the geophysical validation and the planned validation activities will be discussed. Finally the data availability and the source of information will be specified. [1] H. Nett, J. Frerick, T. Paulsen, and G. Levrini, "The atmospheric instruments and their applications: GOMOS, MIPAS and SCIAMACHY", ESA Bulletin (ISSN 0376-4265), No. 106, p. 77 - 87 (2001) [2] J. Frerick, B. Duesmann, and M. Canela, "2010 and beyond - The ENVISAT mission extension", Proc. ‘Envisat Symposium 2007', Montreux, Switzerland, 23-27 April 2007 (ESA SP-636, July 2007)

EPA Region 1 Environmentally Sensitive Areas

EPA Pesticide Factsheets

This coverage represents polygon equivalents of environmentally sensitive areas (ESA) in EPA Region I. ESAs were developed as part of an EPA headquarters initiative based on reviews of various regulatory and guidance documents, as well as phone interviews with federal/state/local government agencies and private organizations. ESAs include, but are not limited to, wetlands, biological resources, habitats, national parks, archaeological/historic sites, natural heritage areas, tribal lands, drinking water intakes, marinas/boat ramps, wildlife areas, etc.

Excited state absorption spectra of dissolved and aggregated distyrylbenzene: A TD-DFT state and vibronic analysis

NASA Astrophysics Data System (ADS)

Oliveira, Eliezer Fernando; Shi, Junqing; Lavarda, Francisco Carlos; Lüer, Larry; Milián-Medina, Begoña; Gierschner, Johannes

2017-07-01

A time-dependent density functional theory study is performed to reveal the excited state absorption (ESA) features of distyrylbenzene (DSB), a prototype π-conjugated organic oligomer. Starting with a didactic insight to ESA based on simple molecular orbital and configuration considerations, the performance of various density functional theory functionals is tested to reveal the full vibronic ESA features of DSB at short and long probe delay times.

ESA personal communications and digital audio broadcasting systems based on non-geostationary satellites

NASA Technical Reports Server (NTRS)

Logalbo, P.; Benedicto, J.; Viola, R.

1993-01-01

Personal Communications and Digital Audio Broadcasting are two new services that the European Space Agency (ESA) is investigating for future European and Global Mobile Satellite systems. ESA is active in promoting these services in their various mission options including non-geostationary and geostationary satellite systems. A Medium Altitude Global Satellite System (MAGSS) for global personal communications at L and S-band, and a Multiregional Highly inclined Elliptical Orbit (M-HEO) system for multiregional digital audio broadcasting at L-band are described. Both systems are being investigated by ESA in the context of future programs, such as Archimedes, which are intended to demonstrate the new services and to develop the technology for future non-geostationary mobile communication and broadcasting satellites.

Security aspects of space operations data

NASA Technical Reports Server (NTRS)

Schmitz, Stefan

1993-01-01

This paper deals with data security. It identifies security threats to European Space Agency's (ESA) In Orbit Infrastructure Ground Segment (IOI GS) and proposes a method of dealing with its complex data structures from the security point of view. It is part of the 'Analysis of Failure Modes, Effects Hazards and Risks of the IOI GS for Operations, including Backup Facilities and Functions' carried out on behalf of the European Space Operations Center (ESOC). The security part of this analysis has been prepared with the following aspects in mind: ESA's large decentralized ground facilities for operations, the multiple organizations/users involved in the operations and the developments of ground data systems, and the large heterogeneous network structure enabling access to (sensitive) data which does involve crossing organizational boundaries. An IOI GS data objects classification is introduced to determine the extent of the necessary protection mechanisms. The proposal of security countermeasures is oriented towards the European 'Information Technology Security Evaluation Criteria (ITSEC)' whose hierarchically organized requirements can be directly mapped to the security sensitivity classification.

75 FR 28568 - Takes of Marine Mammals Incidental to Specified Activities; Marine Geophysical Survey in the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-21

.... SUPPLEMENTARY INFORMATION: Background Section 101(a)(5)(D) of the MMPA (16 U.S.C. 1371 (a)(5)(D)) directs the... output and the shape of the frequency spectrum for the single 40-in\\3\\ airgun; thus the predicted safety... under the U.S. Endangered Species Act of 1973 (ESA; 16 U.S.C. 1531 et seq.), including the north Pacific...

Dynamics of ejecta from the binary asteroid Didymos, the target of the AIDA mission

NASA Astrophysics Data System (ADS)

Michel, Patrick; Yu, Yang; Schwartz, Stephen; Naidu, Shantanu; Benner, Lance

2016-04-01

The AIDA space mission, a collaborative effort between ESA and NASA, aims to characterize the near-Earth asteroid binary (65803) Didymos and to perform a kinetic impactor demonstration on the small moon of the binary system. Our study presents a multi-scale dynamical model of the ejecta cloud produced by a hypervelocity impact, which enables us to compute the ejecta properties at different spatial and time scales. This model is applied to the impact into the small moon of Didymos on October 2022 as considered by the AIDA mission. We model the process by including as much practical information as possible, e.g., the gravitational environment influenced by the non-spherical shapes of the bodies (based on the observed shape of the primary), the solar tides, and the solar radiation pressure. Our simulations show where and for how long the ejecta cloud evolves with time for the considered ejecta initial conditions. This information is used to assess the potential hazard to the ESA Asteroid Impact Mission (AIM) observing spacecraft and to determine the safest positions. This study is performed with support of the European Space Agency and in the framework of the NEOShield-2 project that has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 640351.

Evaluating ESA CCI Soil Moisture in East Africa

NASA Technical Reports Server (NTRS)

McNally, Amy; Shukla, Shraddhanand; Arsenault, Kristi R.; Wang, Shugong; Peters-Lidard, Christa D.; Verdin, James P.

2016-01-01

To assess growing season conditions where ground based observations are limited or unavailable, food security and agricultural drought monitoring analysts rely on publicly available remotely sensed rainfall and vegetation greenness. There are also remotely sensed soil moisture observations from missions like the European Space Agency (ESA) Soil Moisture and Ocean Salinity (SMOS) and NASAs Soil Moisture Active Passive (SMAP), however these time series are still too short to conduct studies that demonstrate the utility of these data for operational applications, or to provide historical context for extreme wet or dry events. To promote the use of remotely sensed soil moisture in agricultural drought and food security monitoring, we use East Africa as a case study to evaluate the quality of a 30+ year time series of merged active-passive microwave soil moisture from the ESA Climate Change Initiative (CCI-SM). Compared to the Normalized Difference Vegetation index (NDVI) and modeled soil moisture products, we found substantial spatial and temporal gaps in the early part of the CCI-SM record, with adequate data coverage beginning in 1992. From this point forward, growing season CCI-SM anomalies were well correlated (R greater than 0.5) with modeled, seasonal soil moisture, and in some regions, NDVI. We use correlation analysis and qualitative comparisons at seasonal time scales to show that remotely sensed soil moisture can add information to a convergence of evidence framework that traditionally relies on rainfall and NDVI in moderately vegetated regions.

Laser Experiments with ARTEMIS Satellite in Cloudy Conditions

NASA Astrophysics Data System (ADS)

Kuzkov, Volodymyr; Sodnik, Zoran; Kuzkov, Sergii; Caramia, Vincenzo

2014-05-01

In July 2001, the ARTEMIS satellite with laser communication terminal OPALE on board was launched. 1789 laser communications sessions were performed between ARTEMIS and SPOT-4 (PASTEL) from 01 April 2003 to 09 January 2008 with total duration of 378 hours. In addition ESA's Optical Ground Station (OGS) performed laser communication experiments with OPALE in various atmospheric conditions. Since the launch of ARTEMIS, the amount of information handled by geostationary telecommunication satellites has increased dramatically and so has the demand for data rate that needs to be transmitted from ground. With limited bandwidth allocations in the radio frequency bands interest has grown for laser communication feeder link technology. In this respect there is interest to compare the influence of atmosphere conditions in different atmospheric regions with respect to laser transmission. Two locations are being compared, namely ESA's OGS (located in an altitude of 2400 m above sea level) and the Main Astronomical Observatory of Ukraine (MAO) (located at an altitude of 190 m above sea level). In 2002 MAO started the development of a ground laser communication system for the AZT-2 telescope. The MAO developed compact laser communication system is called LACES (Laser Atmosphere and Communication Experiments with Satellites) [1] and the work was supported by the National Space Agency of Ukraine and by ESA. The beacon laser from OPALE was occasionally detected even in cloudy conditions and an anomalous atmospheric refraction at low elevation angles was observed. The main results of laser experiments with ARTEMIS through clouds are presented in the paper.

ESA's space science programme

NASA Astrophysics Data System (ADS)

Volonte, S.

2018-04-01

The Space Science Programme of ESA encompasses three broad areas of investigation, namely solar system science (the Sun, the planets and space plasmas), fundamental physics and space astronomy and astrophysics.

Ulysses, the end of an extraordinary mission

NASA Astrophysics Data System (ADS)

2008-06-01

Ulysses, a pioneering ESA/NASA mission, was launched in October 1990 to explore uncharted territories - the regions above and below the Sun’s poles - and study our star’s sphere of influence, or heliosphere, in the four dimensions of space and time. Originally designed for a lifetime of five years, the mission has surpassed all expectations. The reams of data Ulysses has returned have forever changed the way scientists view the Sun and its effect on the space surrounding it. Media representatives interested in attending the press conference are invited to register using the attached form. Those not able to attend will have the opportunity to follow the press conference using the following phone number: +33 1 56785733 (listening-mode only). The programme of the event is as follows: The Ulysses Legacy Press Conference 12 June 2008, 15:30, Room 137, ESA Headquarters, 8-10 rue Mario-Nikis, Paris Event programme 15:30 Welcome, by David Southwood, ESA Director of Science and Robotic Exploration (with a joint ESA/NASA statement) 15:40 Ulysses: a modern-day Odyssey, by Richard Marsden, ESA Ulysses Project Scientist and Mission Manager 15:50 The Ulysses scientific legacy: Inside the heliosphere, by Richard Marsden,ESA Ulysses Project Scientist and Mission Manager 16:00 The Ulysses scientific legacy: Outside the heliosphere, by Ed Smith, NASA Ulysses Project Scientist 16:10 Ulysses, the over-achiever: challenges and successes of a 17-year-old mission, by Nigel Angold, ESA Ulysses Mission Operations Manager 16:20 Questions and Answers, Panelists: David Southwood, Richard Marsden, Ed Smith, Nigel Angold and Ed Massey (NASA Ulysses Project Manager) 16:40 Interview opportunities 17:30 End of event

Exomars 2018 Rover Pasteur Payload

NASA Astrophysics Data System (ADS)

Debus, Andre; Bacher, M.; Ball, A.; Barcos, O.; Bethge, B.; Gaubert, F.; Haldemann, A.; Lindner, R.; Pacros, A.; Trautner, R.; Vag, J.

ars programme is a joint ESA-NASA program having exobiology as one of the key science objectives. It is divided into 2 missions: the first mission is ESA-led with an ESA orbiter and an ESA Entry, Descent and Landing (EDL) demonstrator, launched in 2016 by NASA, and the second mission is NASA-led, launched in 2018 by NASA carrying an ESA rover and a NASA rover both deployed by a single NASA EDL system. For ESA, the ExoMars programme will demonstrate key flight and in situ enabling technologies in support of the European ambitions for future exploration missions, as outlined in the Aurora Declaration. While the ExoMars 2016 mission will accomplish a technological objective (Entry, Descent and Landing of a payload on the surface) and a Scientific objective (investigation of Martian atmospheric trace gases and their sources, focussing particularly on methane), the ExoMars 2018 ESA Rover will carry a comprehensive and coherent suite of analytical instruments dedicated to exobiology and geology research: the Pasteur Payload (PPL). This payload includes a selection of complementary instruments, having the following goals: to search for signs of past and present life on Mars and to investigate the water/geochemical environment as a function of depth in the shallow subsurface. The ExoMars Rover includes a drill for accessing underground materials, and a Sample Preparation and Distribution System. The Rover will travel several kilometres looking for sites warranting further investigation, where it will collect and analyse samples from within outcrops and from the subsurface for traces of complex organic molecules. In addition to further details on this Exomars 2018 rover mission, this presentation will focus on the scientific objectives and the instruments needed to achieve them, including details of how the Pasteur Payload as a whole addresses Mars research objectives.

Can Bradyrhizobium strains inoculation reduce water deficit effects on peanuts?

PubMed

Barbosa, D D; Brito, S L; Fernandes, P D; Fernandes-Júnior, P I; Lima, L M

2018-06-09

Drought is one of the environmental factors that most affects peanut cultivation in semi-arid regions, resulting in economic losses to growers. However, growth promoting bacteria are able to reduce water deficit damage in some plant species. In this context, this study aimed to evaluate the interaction of Bradyrhizobium strains reducing water stress effects on peanut genotypes by antioxidant enzymes activities, leaf gas exchanges and vegetative growth, as well as to determine the taxonomic positioning of strain ESA 123. The 16S rRNA gene of ESA 123 was amplified by PCR and sequenced by dideoxy Sanger sequencing method. An experiment was performed in greenhouse with three peanut genotypes (BRS Havana, CNPA 76 AM and 2012-4), two Bradyrhizobium strains (SEMIA 6144 and ESA 123), a mineral source of N and an absolute control (without N) under two water regimes (with and without irrigation). Seeds of peanut were sown and the plants were grown until 30 days after emergence. On the 20th day, the water deficit plants group had their irrigation suspended for 10 days. At in silico analyzes, ESA 123 presented 98.97% similarity with the type strain of B. kavangense. Leaf gas exchange was affected by water deficit; as well as alteration of antioxidant activities and reduction of vegetative growth variables. However, some plants inoculated with SEMIA 6144 and ESA 123 strains presented lower reductions and increment of some evaluated variables, mainly the ones inoculated with the ESA 123 strain, Bradyrhizobium sp. from the semi-arid region of Northeast Brazil. This data suggests beneficial effects of the peanut-Bradyrhizobium interaction in a water stress condition, specially with the ESA 123 strain.

The side-to-side fashion for individual distal coronary anastomosis using venous conduit.

PubMed

Kato, Takayoshi; Tsunekawa, Tomohiro; Motoji, Yusuke; Hirakawa, Akihiro; Okawa, Yasuhide; Tomita, Shinji

2017-04-01

Regarding to coronary artery bypass grafting (CABG), the end-to-side anastomosis (ESA) has been performed as a gold standard. Recently, the effectiveness of the distal side-to-side anastomosis (SSA) in CABG using internal mammary artery has been reported. The benefit of SSA comparing to ESA also has been disclosed by computing simulation. However, use of SSA by venous conduit for individual CABG has not been reported. In this study, we investigated feasibility of SSA. From January 2013 to October 2014, we conducted 114 CABGs. There were 92 venous distal anastomoses without sequential anastomotic site (61 SSA and 31 ESA). The anastomosis was evaluated before discharge and at 1 year after the procedure by angiography or multi-detector row computed tomographic coronary angiography. The median values for time to anastomosis were 13 min in the two group (p = 0.89). There was no revision of anastomosis in both groups. Additional stitches for hemostasis were required significantly less in SSA than ESA (18.0 vs 45.2 %, respectively, p < 0.05). Early angiographic patency; 96.6 % for SSA vs 93.5 % for ESA (p = 0.50), and percentage of good anastomotic figure; 91.2 % for SSA vs 87.1 % for ESA (p = 0.54) were similar in both groups. The angiographic patency at 1 year were 92.9 % for SSA and 81.0 % for ESA (p = 0.16). There was no predictive factor for early and late graft failure. Our study showed feasibility of SSA using venous conduit in individual CABG based on early and mid-term angiographic results. This anastomotic fashion is easy to perform and maybe beneficial in blood flow pattern.

15 CFR Supplement No. 2 to Part 774 - General Technology and Software Notes

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false General Technology and Software Notes... Software Notes 1. General Technology Note. The export of “technology” that is “required” for the... necessary” information. 2. General Software Note. License Exception TSU (“mass market” software) is...

15 CFR Supplement No. 2 to Part 774 - General Technology and Software Notes

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false General Technology and Software Notes... Software Notes 1. General Technology Note. The export of “technology” that is “required” for the... necessary” information. 2. General Software Note. License Exception TSU (“mass market” software) is...

15 CFR Supplement No. 2 to Part 774 - General Technology and Software Notes

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false General Technology and Software Notes... Software Notes 1. General Technology Note. The export of “technology” that is “required” for the... necessary” information. 2. General Software Note. License Exception TSU (“mass market” software) is...

7 CFR 1942.19 - Information pertaining to preparation of notes or bonds and bond transcript documents for public...

Code of Federal Regulations, 2010 CFR

2010-01-01

... includes information for use by public body applicants in the preparation and issuance of evidence of debt... 7 Agriculture 13 2010-01-01 2009-01-01 true Information pertaining to preparation of notes or... REGULATIONS (CONTINUED) ASSOCIATIONS Community Facility Loans § 1942.19 Information pertaining to preparation...

The Challenges and Opportunities of a Commercial Astronaut Mission to the ISS

NASA Astrophysics Data System (ADS)

Mirra, C.; Carl, S.

2002-01-01

ISS flight opportunities for ESA astronauts are considered as a vital source to meet the objectives (utilisation, operation and political), which Europe has established in participating to the International Space Station programme. Recent internal ESA assessments have demonstrated that, in order to satisfy the objectives drawn in the ESA ISS Exploitation programme, a rate of three flights per year for European Astronauts should be maintained as minimum objective. Since the establishment of a single European Astronaut Corps and having regard of the ISS flight opportunities provided through national space agencies, the current European astronauts flight rate is rather lower than the above three flights per year. In order to improve this situation, in the context of the activation of the ESA ISS Commercialisation programme, the Agency contracted Intospace to develop the conditions for the establishment of ESA astronaut missions with the financial support of both ESA and the private sector or, in future, the latter only. The study led to the definition of a "commercial astronaut", as a member of the European Astronaut Corp that will be assigned the responsibility to perform research and commercial space projects in a given ISS mission scenario. This paper will present the recent outcomes of a detailed study phase, including highlights on possible implementation of a private sector-supported astronaut mission to the ISS.

Automated identification of wound information in clinical notes of patients with heart diseases: Developing and validating a natural language processing application.

PubMed

Topaz, Maxim; Lai, Kenneth; Dowding, Dawn; Lei, Victor J; Zisberg, Anna; Bowles, Kathryn H; Zhou, Li

2016-12-01

Electronic health records are being increasingly used by nurses with up to 80% of the health data recorded as free text. However, only a few studies have developed nursing-relevant tools that help busy clinicians to identify information they need at the point of care. This study developed and validated one of the first automated natural language processing applications to extract wound information (wound type, pressure ulcer stage, wound size, anatomic location, and wound treatment) from free text clinical notes. First, two human annotators manually reviewed a purposeful training sample (n=360) and random test sample (n=1100) of clinical notes (including 50% discharge summaries and 50% outpatient notes), identified wound cases, and created a gold standard dataset. We then trained and tested our natural language processing system (known as MTERMS) to process the wound information. Finally, we assessed our automated approach by comparing system-generated findings against the gold standard. We also compared the prevalence of wound cases identified from free-text data with coded diagnoses in the structured data. The testing dataset included 101 notes (9.2%) with wound information. The overall system performance was good (F-measure is a compiled measure of system's accuracy=92.7%), with best results for wound treatment (F-measure=95.7%) and poorest results for wound size (F-measure=81.9%). Only 46.5% of wound notes had a structured code for a wound diagnosis. The natural language processing system achieved good performance on a subset of randomly selected discharge summaries and outpatient notes. In more than half of the wound notes, there were no coded wound diagnoses, which highlight the significance of using natural language processing to enrich clinical decision making. Our future steps will include expansion of the application's information coverage to other relevant wound factors and validation of the model with external data. Copyright © 2016 Elsevier Ltd. All rights reserved.

International cooperation in the field of space life sciences: European Space Agency's (ESA) perspectives.

PubMed

Oser, H

1989-08-01

International cooperation in life sciences, as in any other of the space research fields, takes place at two distinct levels: scientist to scientist, or agency to agency. This article is more concerned with the agency to agency level, which involves the arrangements made between two partners for the flying of experiments and/or hardware on space missions. International cooperation is inherent to the European Space Agency (ESA), since it consists of 13 member states (Austria, Belgium, Denmark, France, Ireland, Italy, the Netherlands, Norway, Spain, Sweden, Switzerland, United Kingdom, and West Germany) and one associated member, Finland. ESA also has special cooperative arrangements with Canada. Life sciences research in ESA is carried out within the Microgravity Research Program, an optional program to which member states (in this case all but Austria and Ireland) contribute "a la carte," and receive their "share" accordingly. Therefore, many of the activities are naturally linked to international arrangements within the member states, and also to arrangements between the agencies, with life sciences being the dominant activity between NASA and ESA.

Short duration microgravity experiments in physical and life sciences during parabolic flights: the first 30 ESA campaigns.

PubMed

Pletser, Vladimir

2004-11-01

Aircraft parabolic flights provide repetitively up to 20 s of reduced gravity during ballistic flight manoeuvres. Parabolic flights are used to conduct short microgravity investigations in Physical and Life Sciences, to test instrumentation and to train astronauts before a space flight. The European Space Agency (ESA) has organized since 1984 thirty parabolic flight campaigns for microgravity research experiments utilizing six different airplanes. More than 360 experiments were successfully conducted during more than 2800 parabolas, representing a cumulated weightlessness time of 15 h 30 m. This paper presents the short duration microgravity research programme of ESA. The experiments conducted during these campaigns are summarized, and the different airplanes used by ESA are shortly presented. The technical capabilities of the Airbus A300 'Zero-G' are addressed. Some Physical Science, Technology and Life Science experiments performed during the last ESA campaigns with the Airbus A300 are presented to show the interest of this unique microgravity research tool to complement, support and prepare orbital microgravity investigations. c2004 Elsevier Ltd. All rights reserved.

Binder-free carbon nanotube electrode for electrochemical removal of chromium.

PubMed

Wang, Haitao; Na, Chongzheng

2014-11-26

Electrochemical treatment of chromium-containing wastewater has the advantage of simultaneously reducing hexavalent chromium (CrVI) and reversibly adsorbing the trivalent product (CrIII), thereby minimizing the generation of waste for disposal and providing an opportunity for resource reuse. The application of electrochemical treatment of chromium is often limited by the available electrochemical surface area (ESA) of conventional electrodes with flat surfaces. Here, we report the preparation and evaluation of carbon nanotube (CNT) electrodes consisting of vertically aligned CNT arrays directly grown on stainless steel mesh (SSM). We show that the 3-D organization of CNT arrays increases ESA up to 13 times compared to SSM. The increase of ESA is correlated with the length of CNTs, consistent with a mechanism of roughness-induced ESA enhancement. The increase of ESA directly benefits CrVI reduction by proportionally accelerating reduction without compromising the electrode's ability to adsorb CrIII. Our results suggest that the rational design of electrodes with hierarchical structures represents a feasible approach to improve the performance of electrochemical treatment of contaminated water.

Basic Radar Altimetry Toolbox: Tools and Tutorial to Use Cryosat Data

NASA Astrophysics Data System (ADS)

Benveniste, J.; Bronner, E.; Dinardo, S.; Lucas, B. M.; Rosmorduc, V.; Earith, D.; Niemeijer, S.

2011-12-01

Radar altimetry is very much a technique expanding its applications. Even If quite a lot of effort has been invested for oceanography users, the use of Altimetry data for cryosphere application, especially with the new ESA CryoSat-2 mission data is still somehow tedious for new Altimetry data products users. ESA and CNES therfore developed the Basic Radar Altimetry Toolbox a few years ago, and are improving and upgrading it to fit new missions and the growing number of altimetry uses. The Basic Radar Altimetry Toolbox is an "all-altimeter" collection of tools, tutorials and documents designed to facilitate the use of radar altimetry data. The software is able: - to read most distributed radar altimetry data, from ERS-1 & 2, Topex/Poseidon, Geosat Follow-on, Jason-1, Envisat, Jason- 2, CryoSat, the future Saral missions and is ready for adaptation to Sentinel-3 products - to perform some processing, data editing and statistic, - and to visualize the results. It can be used at several levels/several ways: - as a data reading tool, with APIs for C, Fortran, Matlab and IDL - as processing/extraction routines, through the on-line command mode - as an educational and a quick-look tool, with the graphical user interface As part of the Toolbox, a Radar Altimetry Tutorial gives general information about altimetry, the technique involved and its applications, as well as an overview of past, present and future missions, including information on how to access data and additional software and documentation. It also presents a series of data use cases, covering all uses of altimetry over ocean, cryosphere and land, showing the basic methods for some of the most frequent manners of using altimetry data. It is an opportunity to teach remote sensing with practical training. It has been available since April 2007, and had been demonstrated during training courses and scientific meetings. About 2000 people downloaded it (Summer 2011), with many "newcomers" to altimetry among them, including teachers and professors, worldwide. Users' feedback, developments in altimetry, and practice, showed that new interesting features could be added. Some have been added and/or improved in the recent version release (v3.0.1). Others are in discussion for future development. Data use cases on CryoSat data use will be presented. BRAT is developed under contract with ESA and CNES. It is available at http://www.altimetry.info and http://earth.esa.int/brat/

78 FR 56222 - Agency Information Collection Activities; Comment Request; Highly Qualified Teachers Clearance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-12

..., commercial delivery, or hand delivery. Please note that comments submitted by fax or email and those submitted after the comment period will not be accepted. Written requests for information or comments... respondents, including through the use of information technology. Please note that written comments received...

77 FR 73993 - Agency Information Collection Activities; Comment Request; Indian Education Professional...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-12

... ED-2012-ICCD- 0068 or via postal mail, commercial delivery, or hand delivery. Please note that.... Written requests for information or comments submitted by postal mail or delivery should be addressed to..., including through the use of information technology. Please note that written comments received in response...

78 FR 54459 - Agency Information Collection Activities; Comment Request; Student Assistance General Provisions...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-04

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78 FR 18576 - Agency Information Collection Activities; Comment Request; Experimental Sites Data Collection...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-27

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Accurate mass analysis of ethanesulfonic acid degradates of acetochlor and alachlor using high-performance liquid chromatography and time-of-flight mass spectrometry

USGS Publications Warehouse

Thurman, E.M.; Ferrer, I.; Parry, R.

2002-01-01

Degradates of acetochlor and alachlor (ethanesulfonic acids, ESAs) were analyzed in both standards and in a groundwater sample using high-performance liquid chromatography-time-of-flight mass spectrometry with electrospray ionization. The negative pseudomolecular ion of the secondary amide of acetochlor ESA and alachlor ESA gave average masses of 256.0750??0.0049 amu and 270.0786??0.0064 amu respectively. Acetochlor and alachlor ESA gave similar masses of 314.1098??0.0061 amu and 314.1153??0.0048 amu; however, they could not be distinguished by accurate mass because they have the same empirical formula. On the other hand, they may be distinguished using positive-ion electrospray because of different fragmentation spectra, which did not occur using negative-ion electrospray.

Accurate mass analysis of ethanesulfonic acid degradates of acetochlor and alachlor using high-performance liquid chromatography and time-of-flight mass spectrometry

USGS Publications Warehouse

Thurman, E.M.; Ferrer, Imma; Parry, R.

2002-01-01

Degradates of acetochlor and alachlor (ethanesulfonic acids, ESAs) were analyzed in both standards and in a groundwater sample using high-performance liquid chromatography-time-of-flight mass spectrometry with electrospray ionization. The negative pseudomolecular ion of the secondary amide of acetochlor ESA and alachlor ESA gave average masses of 256.0750+/-0.0049 amu and 270.0786+/-0.0064 amu respectively. Acetochlor and alachlor ESA gave similar masses of 314.1098+/-0.0061 amu and 314.1153+/-0.0048 amu; however, they could not be distinguished by accurate mass because they have the same empirical formula. On the other hand, they may be distinguished using positive-ion electrospray because of different fragmentation spectra, which did not occur using negative-ion electrospray.

Cloud property datasets retrieved from AVHRR, MODIS, AATSR and MERIS in the framework of the Cloud_cci project

NASA Astrophysics Data System (ADS)

Stengel, Martin; Stapelberg, Stefan; Sus, Oliver; Schlundt, Cornelia; Poulsen, Caroline; Thomas, Gareth; Christensen, Matthew; Carbajal Henken, Cintia; Preusker, Rene; Fischer, Jürgen; Devasthale, Abhay; Willén, Ulrika; Karlsson, Karl-Göran; McGarragh, Gregory R.; Proud, Simon; Povey, Adam C.; Grainger, Roy G.; Fokke Meirink, Jan; Feofilov, Artem; Bennartz, Ralf; Bojanowski, Jedrzej S.; Hollmann, Rainer

2017-11-01

New cloud property datasets based on measurements from the passive imaging satellite sensors AVHRR, MODIS, ATSR2, AATSR and MERIS are presented. Two retrieval systems were developed that include components for cloud detection and cloud typing followed by cloud property retrievals based on the optimal estimation (OE) technique. The OE-based retrievals are applied to simultaneously retrieve cloud-top pressure, cloud particle effective radius and cloud optical thickness using measurements at visible, near-infrared and thermal infrared wavelengths, which ensures spectral consistency. The retrieved cloud properties are further processed to derive cloud-top height, cloud-top temperature, cloud liquid water path, cloud ice water path and spectral cloud albedo. The Cloud_cci products are pixel-based retrievals, daily composites of those on a global equal-angle latitude-longitude grid, and monthly cloud properties such as averages, standard deviations and histograms, also on a global grid. All products include rigorous propagation of the retrieval and sampling uncertainties. Grouping the orbital properties of the sensor families, six datasets have been defined, which are named AVHRR-AM, AVHRR-PM, MODIS-Terra, MODIS-Aqua, ATSR2-AATSR and MERIS+AATSR, each comprising a specific subset of all available sensors. The individual characteristics of the datasets are presented together with a summary of the retrieval systems and measurement records on which the dataset generation were based. Example validation results are given, based on comparisons to well-established reference observations, which demonstrate the good quality of the data. In particular the ensured spectral consistency and the rigorous uncertainty propagation through all processing levels can be considered as new features of the Cloud_cci datasets compared to existing datasets. In addition, the consistency among the individual datasets allows for a potential combination of them as well as facilitates studies on the impact of temporal sampling and spatial resolution on cloud climatologies.

For each dataset a digital object identifier has been issued:

Cloud_cci AVHRR-AM: https://doi.org/10.5676/DWD/ESA_Cloud_cci/AVHRR-AM/V002

Cloud_cci AVHRR-PM: https://doi.org/10.5676/DWD/ESA_Cloud_cci/AVHRR-PM/V002

Cloud_cci MODIS-Terra: https://doi.org/10.5676/DWD/ESA_Cloud_cci/MODIS-Terra/V002

Cloud_cci MODIS-Aqua: https://doi.org/10.5676/DWD/ESA_Cloud_cci/MODIS-Aqua/V002

Cloud_cci ATSR2-AATSR: https://doi.org/10.5676/DWD/ESA_Cloud_cci/ATSR2-AATSR/V002

Cloud_cci MERIS+AATSR: https://doi.org/10.5676/DWD/ESA_Cloud_cci/MERIS+AATSR/V002

A Guide to Field Notes for Qualitative Research: Context and Conversation.

PubMed

Phillippi, Julia; Lauderdale, Jana

2018-02-01

Field notes are widely recommended in qualitative research as a means of documenting needed contextual information. With growing use of data sharing, secondary analysis, and metasynthesis, field notes ensure rich context persists beyond the original research team. However, while widely regarded as essential, there is not a guide to field note collection within the literature to guide researchers. Using the qualitative literature and previous research experience, we provide a concise guide to collection, incorporation, and dissemination of field notes. We provide a description of field note content for contextualization of an entire study as well as individual interviews and focus groups. In addition, we provide two "sketch note" guides, one for study context and one for individual interviews or focus groups for use in the field. Our guides are congruent with many qualitative and mixed methodologies and ensure contextual information is collected, stored, and disseminated as an essential component of ethical, rigorous qualitative research.

1. On note taking.

PubMed

Plaut, Alfred B J

2005-02-01

In this paper the author explores the theoretical and technical issues relating to taking notes of analytic sessions, using an introspective approach. The paper discusses the lack of a consistent approach to note taking amongst analysts and sets out to demonstrate that systematic note taking can be helpful to the analyst. The author describes his discovery that an initial phase where as much data was recorded as possible did not prove to be reliably helpful in clinical work and initially actively interfered with recall in subsequent sessions. The impact of the nature of the analytic session itself and the focus of the analyst's interest on recall is discussed. The author then describes how he modified his note taking technique to classify information from sessions into four categories which enabled the analyst to select which information to record in notes. The characteristics of memory and its constructive nature are discussed in relation to the problems that arise in making accurate notes of analytic sessions.

Using Guided Notes to Increase the Understanding of Anatomy and Physiology in 11th Grade Science Students

NASA Astrophysics Data System (ADS)

Mariano, Jay

A survey of over 500 science teachers reported that two thirds of their science classes were lecture based lessons where students were required to listen and take notes (Boyle, 2010). In addition to taking notes from lectures, note taking is a necessary skill to possess to record scientific observations and procedures and record information during class. Guided notes is a pedagogical method in which the instructor prepares and provides students with a modified form of lecture information to guide students (Neef, McCord, & Ferreri, 2006). This study examined the extent to which the use of guided notes in a unit of study of the muscular system of anatomy and physiology positively affected the mastery on content-based assessments for 11 th grade students. The data collection methods included quiz and test scores, a 4-point Likert scale survey, and an open-ended questionnaire. Results of the data revealed that guided notes was one factor that led to mastery in learning content. Additionally, students in this study preferred this method as it helped them to distinguish relevant information allowing more time to listen and focus on the teacher.

Galileo: Power, Pride, and Profit. The Relative Influence of Realist, Ideational, and Liberal Factors on the Galileo Satellite Program

DTIC Science & Technology

2009-01-31

was the DG from 1997 until 2003. Jean - Jacque Dordain became the DG in July 2003 and was reappointed in 2007.10 The official Galileo program...July 2003) ESA Director General Jean - Jacque Dordain produced an internal position paper which explicitly stated that ESA now interpreted “peaceful...countries outside Europe. 121 This section relies heavily on reporting of a January 17, 2007 press conference by ESA Director General Jean - Jacques

ARTES: the future of satellite telecommunication

NASA Astrophysics Data System (ADS)

González-Blázquez, Angel; Detain, Dominique

2005-08-01

Throughout its 30-year existence, ESA has played a key role by providing telecommunications infrastructures that have allowed the in-orbit validation, qualification and demonstration of equipment, technology and services. In the past, this has been achieved through the provision of dedicated satellites like OTS, Marecs, Olympus and Artemis, as well as by the implementation of piggy-back payloads on other ESA or commercial satellites. Today, due to the importance of satellite telecommunications, ESA continues to support this sector mainly through its ARTES - Advanced Research in Telecommunications - Programme.

15 CFR Supplement No. 2 to Part 774 - General Technology and Software Notes

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false General Technology and Software Notes... Software Notes 1. General Technology Note. The export of “technology” that is “required” for the... necessary” information. 2. General Software Note. License Exception TSU (mass market software) (see § 740.13...

Additional spectra of asteroid 1996 FG3, backup target of the ESA MarcoPolo-R mission

NASA Astrophysics Data System (ADS)

de León, J.; Lorenzi, V.; Alí-Lagoa, V.; Licandro, J.; Pinilla-Alonso, N.; Campins, H.

2013-08-01

Context. Near-Earth binary asteroid (175706) 1996 FG3 is the current backup target of the ESA MarcoPolo-R mission, selected for the study phase of ESA M3 missions. It is a primitive (C-type) asteroid that shows significant variation in its visible and near-infrared spectra. Aims: Here we present new visible and near-infrared spectra of 1996 FG3. We compare our new data with other published spectra, analysing the variation in the spectral slope. The asteroid will not be observable again over the next three years at least. Methods: We obtained visible and near-infrared spectra using DOLORES and NICS instruments, respectively, at the Telescopio Nazionale Galileo (TNG), a 3.6 m telescope located at El Roque de los Muchachos Observatory in La Palma, Spain. To compare with other published spectra of the asteroid, we computed the spectral slope S', and studied any plausible correlation of this quantity with the phase angle (α). Results: In the case of visible spectra, we find a variation in spectral slope of ΔS' = 0.15 ± 0.10%/103 Å/° for 3°<α< 18°, which is in good agreement with the values found in the literature for the phase reddening effect. In the case of the near-infrared, there seems to be a trend between the reddening of the spectra and the phase angle, excluding one point. We find a variation in the slope of ΔS' = 0.04 ± 0.08%/103 Å/° for 6° < α < 51°. Our computed variation in S' is in good agreement with the only two values found in the literature for the phase reddening in the near-infrared. Conclusions: The variation in the spectral slope of asteroid 1996 FG3 shows a trend with the phase angle at the time of the observations, both in the visible and the near-infrared. It is worth noting that, to fully explain this spectral variability we should take into account other factors, like the position of the secondary component of the binary asteroid 1999 FG3 with respect to the primary, or the spin axis orientation at the time of the observations. More data are necessary for an analysis of this kind.

ESA's high-energy observatories spot doughnut-shaped cloud with a black-hole filling

NASA Astrophysics Data System (ADS)

2004-07-01

hi-res Size hi-res: 7265 KB Credits: ESA, V. Beckmann (GSFC) Doughnut-shaped cloud surrounds black hole This artist's impression shows the thick dust torus that astronomers believe surrounds supermassive black holes and their accretion discs, like the one harboured in the nucleus of the spiral galaxy NGC 4388. When the torus is seen `edge-on’ as in this case, the visible light emitted by the accretion disc is partially blocked. However, the sharp X-ray and gamma-ray eyes of XMM-Newton and Integral can peer through the thick dust and see how the energy released by the accretion disc interacts with and is absorbed by the torus. Black holes are objects so compact and with gravity so strong that not even light can escape from them. Scientists think that `supermassive’ black holes are located in the cores of most galaxies, including our Milky Way galaxy. They can contain the mass of thousands of millions of suns, confined within a region no larger than our Solar System. They appear to be surrounded by a hot, thin disk of accreting gas and, farther out, the thick doughnut-shaped torus. Depending on the inclination of the torus, it can hide the black hole and the hot accretion disc from the line of sight. Galaxies in which a torus blocks the light from the central accretion disc are called `Seyfert 2’ types and are usually faint to optical telescopes. Another theory, however, is that these galaxies appear rather faint because the central black hole is not actively accreting gas and the disc surrounding it is therefore faint. An international team of astronomers led by Dr Volker Beckmann, Goddard Space Flight Center (Greenbelt, USA) has studied one of the nearest objects of this type, a spiral galaxy called NGC 4388, located 65 million light years away in the constellation Virgo. Since NGC 4388 is relatively close, and therefore unusually bright for its class, it is easier to study. Astronomers often study black holes that are aligned face-on, thus avoiding the enshrouding torus. However, Beckmann's group took the path less trodden and studied the central black hole by peering through the torus. With XMM-Newton and Integral, they could detect some of the X-rays and gamma rays, emitted by the accretion disc, which partially penetrate the torus. "By peering right into the torus, we see the black hole phenomenon in a whole new light, or lack of light, as the case may be here," Beckmann said. Beckmann's group saw how different processes around a black hole produce light at different wavelengths. For example, some of the gamma rays produced close to the black hole get absorbed by iron atoms in the torus and are re-emitted at a lower energy. This in fact is how the scientists knew they were seeing `reprocessed’ light farther out. Also, because of the line of sight towards NGC 4388, they knew this iron was from a torus on the same plane as the accretion disk, and not from gas clouds `above’ or `below’ the accretion disk. This new view through the haze has provided valuable insight into the relationship between the black hole, its accretion disc and the doughnut, and supports the torus model in several ways. Gas in the accretion disc close to the black hole reaches high speeds and temperatures (over 100 million degrees, hotter than the Sun) as it races toward the void. The gas radiates predominantly at high energies, in the X-ray wavelengths. According to Beckmann, this light is able to escape the black hole because it is still outside of its border, but ultimately collides with matter in the torus. Some of it is absorbed; some of it is reflected at different wavelengths, like sunlight penetrating a cloud; and the very energetic gamma rays pierce through. "This torus is not as dense as a real doughnut or a true German Krapfen, but it is far hotter - up to a thousand degrees - and loaded with many more calories," Beckmann said. The new observations also pinpoint the origin of the high-energy emission from NGC 4388. While the lower-energy X-rays seen by XMM-Newton appear to come from a diffuse emission, far away from the black hole, the higher-energy X-rays detected by Integral are directly related to the black hole activity. The team could infer the doughnut’s structure and its distance from the black hole by virtue of light that was either reflected or completely absorbed. The torus itself appears to be several hundred light years from the black hole, although the observation could not gauge its diameter, from inside to outside. The result marks the clearest observation of an obscured black hole in X-ray and gamma-ray `colours’, a span of energy nearly a million times wider than the window of visible light, from red to violet. Multi-wavelength studies are increasingly important to understanding black holes, as already demonstrated earlier this year. In May 2004, the European project known as the Astrophysical Virtual Observatory, in which ESA plays a major role, found 30 supermassive black holes that had previously escaped detection behind masking dust clouds. Note for editors This result will appear on The Astrophysical Journal. Besides Volker Beckmann, the author list includes Neil Gehrels, Pascal Favre, Roland Walter, Thierry Courvoisier, Pierre-Olivier Petrucci and Julien Malzac. For more information about the Astrophysical Virtual Observatory programme and how it has allowed European scientists to discover a number of previously hidden black holes, see: http://www.spacetelescope.org/news/html/heic0409.html More about Integral The International Gamma Ray Astrophysics Laboratory (Integral) is the first space observatory that can simultaneously observe celestial objects in gamma rays, X-rays and visible light. Integral was launched on a Russian Proton rocket on 17 October 2002 into a highly elliptical orbit around Earth. Its principal targets include regions of the galaxy where chemical elements are being produced and compact objects, such as black holes. More information on Integral can be found at: http://www.esa.int/esaSC/SEM9P5374OD_0_spk.html More about XMM-Newton XMM-Newton can detect more X-ray sources than any previous observatory and is helping to solve many cosmic mysteries of the violent Universe, from black holes to the formation of galaxies. It was launched on 10 December 1999, using an Ariane-5 rocket from French Guiana. It is expected to return data for a decade. XMM-Newton’s high-tech design uses over 170 wafer-thin cylindrical mirrors spread over three telescopes. Its orbit takes it almost a third of the way to the Moon, so that astronomers can enjoy long, uninterrupted views of celestial objects. More information on XMM-Newton can be found at: http://www.esa.int/esaSC/SEMM8IGHZTD_1_spk.html

Understanding the Recent Increase in Ferritin Levels in United States Dialysis Patients: Potential Impact of Changes in Intravenous Iron and Erythropoiesis-Stimulating Agent Dosing.

PubMed

Karaboyas, Angelo; Zee, Jarcy; Morgenstern, Hal; Nolen, Jacqueline G; Hakim, Raymond; Kalantar-Zadeh, Kamyar; Zager, Philip; Pisoni, Ronald L; Port, Friedrich K; Robinson, Bruce M

2015-10-07

Anemia management changed substantially among dialysis patients in the United States around the time of implementation of the new Centers for Medicare & Medicaid Services bundled payment system and erythropoiesis-stimulating agent (ESA) label change in 2011. Among these, average ferritin levels increased dramatically and have remained high since; this study sought to gain understanding of this sustained rise in ferritin levels. Trends in mean ferritin, hemoglobin, IV iron dose, and ESA dose from 2009 to 2013 were examined in 9735 patients from 91 United States Dialysis Outcomes and Practice Patterns Study facilities. Linear mixed models were used to assess the extent to which intravenous (IV) iron and ESA dose accounted for patients' changes in ferritin over time. Mean ESA dose and hemoglobin levels declined throughout the study. Mean IV iron dose increased from 210 mg/mo in 2009-2010 to a peak of 280 mg/mo in 2011, then declined back to 200 mg/mo and remained stable from 2012 to 2013. Mean ferritin increased from 601 ng/ml in the third quarter of 2009 to 887 ng/ml in the first quarter of 2012; models suggest that higher IV iron dosing was a primary determinant during 2011, but lower ESA doses contributed to the sustained high ferritin levels thereafter. In a subset of 17 facilities that decreased IV iron dose in 2011, mean ferritin rose by 120 ng/ml to 764 ng/ml, which appeared to be primarily due to ESA reduction. Together, changes in IV iron and ESA doses accounted for 46% of the increase in ferritin over the study period. In contrast to expectations, the rise in average IV iron dose did not persist beyond 2011. The sustained rise in ferritin levels in United States dialysis patients after policy changes in 2011, to average levels well in excess of 800 ng/ml, appeared to be partly due to reductions in ESA dosing and not solely IV iron dosing practices. The effect of these changes in ferritin on health outcomes requires further investigation. Copyright © 2015 by the American Society of Nephrology.

Understanding the Recent Increase in Ferritin Levels in United States Dialysis Patients: Potential Impact of Changes in Intravenous Iron and Erythropoiesis-Stimulating Agent Dosing

PubMed Central

Zee, Jarcy; Morgenstern, Hal; Nolen, Jacqueline G.; Hakim, Raymond; Kalantar-Zadeh, Kamyar; Zager, Philip; Pisoni, Ronald L.; Port, Friedrich K.; Robinson, Bruce M.

2015-01-01

Background and objectives Anemia management changed substantially among dialysis patients in the United States around the time of implementation of the new Centers for Medicare & Medicaid Services bundled payment system and erythropoiesis-stimulating agent (ESA) label change in 2011. Among these, average ferritin levels increased dramatically and have remained high since; this study sought to gain understanding of this sustained rise in ferritin levels. Design, setting, participants, & measurements Trends in mean ferritin, hemoglobin, IV iron dose, and ESA dose from 2009 to 2013 were examined in 9735 patients from 91 United States Dialysis Outcomes and Practice Patterns Study facilities. Linear mixed models were used to assess the extent to which intravenous (IV) iron and ESA dose accounted for patients’ changes in ferritin over time. Results Mean ESA dose and hemoglobin levels declined throughout the study. Mean IV iron dose increased from 210 mg/mo in 2009–2010 to a peak of 280 mg/mo in 2011, then declined back to 200 mg/mo and remained stable from 2012 to 2013. Mean ferritin increased from 601 ng/ml in the third quarter of 2009 to 887 ng/ml in the first quarter of 2012; models suggest that higher IV iron dosing was a primary determinant during 2011, but lower ESA doses contributed to the sustained high ferritin levels thereafter. In a subset of 17 facilities that decreased IV iron dose in 2011, mean ferritin rose by 120 ng/ml to 764 ng/ml, which appeared to be primarily due to ESA reduction. Together, changes in IV iron and ESA doses accounted for 46% of the increase in ferritin over the study period. Conclusions In contrast to expectations, the rise in average IV iron dose did not persist beyond 2011. The sustained rise in ferritin levels in United States dialysis patients after policy changes in 2011, to average levels well in excess of 800 ng/ml, appeared to be partly due to reductions in ESA dosing and not solely IV iron dosing practices. The effect of these changes in ferritin on health outcomes requires further investigation. PMID:26286925

Cosmic Vision 2015-2025 media briefing - 19 April 2005

NASA Astrophysics Data System (ADS)

2005-04-01

On 19 April over 150 scientists from all ESA member states will convene at the European Space Research and Technology Centre in Noordwijk, the Netherlands, for a three-day symposium entitled "Trends in Space Science and Cosmic Vision 2015-2025". The conference will include a number of invited talks giving an overview of the scientific themes that will form the basis of future ESA missions. Topics to be addressed now will keep space scientists busy over the next 15-20 years. Amongst them are: the nature of planets beyond our solar system; a possible mission to Jupiter and its moon Europa, or perhaps back to Titan; spotting the first black holes; an interstellar probe powered by a solar sail; and many others. Open questions include the priority ESA should give to near-Earth objects and the threat they pose, or whether and when we should return to a comet after Rosetta. Members of the media are invited to a press conference at 10.00 CET on 19 April, at ESA's Visitor Centre (Space Expo) in Noordwijk, the Netherlands. The press briefing will provide an overview of the current ideas for new missions, the expected results and their implications for the advancement of science and human knowledge. Programme 09.30 - Arrival/Registration/Coffee in the Mars Corner at Space Expo 10.00 - Welcome 10.00 - Present and future of ESA's Science Programme - Prof. David Southwood (ESA Director of Science) 10.15 - Hubble: Fifteen years of discovery - Dr Duccio Macchetto (Head of ESA Space Telescope Division) 10.30 - Europe's space science in fifteen years’ time - Prof. Giovanni Bignami (Chairman of ESA Space Science Advisory Committee) 10.45 - Question and answer time 11.00 - End Members of the media interested in attending the briefing or listening to it via telephone should complete the form below and return it as soon as possible by fax as indicated. Instructions on how to listen in via the telephone line will be given to those that register. The presentation material will be made available to registered participants via the worldwide web shortly before the briefing.

In vitro chronotropic effects of Erythrina senegalensis DC (Fabaceae) aqueous extract on mouse heart slice and pluripotent stem cell-derived cardiomyocytes.

PubMed

Nembo, Erastus Nembu; Atsamo, Albert Donatien; Nguelefack, Télesphore Benoît; Kamanyi, Albert; Hescheler, Jürgen; Nguemo, Filomain

2015-05-13

Erythrina senegalensis DC (Fabaceae) bark is commonly used in sub-Saharan traditional medicine for the treatment of many diseases including gastrointestinal disorders and cardiovascular diseases. In this study, we investigated the effect of the aqueous extract of the stem bark of Erythrina senegalensis on the contractile properties of mouse ventricular slices and human induced pluripotent stem (hiPS) cell-derived cardiomyocytes. We also investigated the cytotoxic effect of the extract on mouse embryonic stem (ES) cells differentiating into cardiomyocytes (CMs). We used well-established electrophysiological technologies to assess the effect of Erythrina senegalensis aqueous extract (ESAE) on the beating activity of mouse ventricular slices, mouse ES and hiPS cell-derived CMs. To study the cytotoxic effect of our extract, differentiating mouse ES cells were exposed to different concentrations of ESAE. EB morphology was assessed by microscopy at different stages of differentiation whereas cell viability was measured by flow cytometry, fluorometry and immunocytochemistry. The electrical activity of CMs and heart slices were respectively captured by the patch clamp technique and microelectrode array (MEA) method following ESAE acute exposure. Our findings revealed that ESAE exhibits a biphasic chronotropic activity on mouse ventricular slices with an initial low dose (0.001 and 0.01 µg/mL) decrease in beating activity followed by a corresponding significant increase in chronotropic activity at higher doses above 10 µg/mL. The muscarinic receptor blocker, atropine abolished the negative chronotropic activity of ESAE, while propranolol successfully blocked its positive chronotropic activity. ESAE showed a significant dose-dependent positive chronotropic activity on hiPS cell-derived CMs. Also, though not significantly, ESAE decreased cell viability and increased total caspase-3/7 activity of mouse ES cells in a concentration-dependent manner. Erythrina senegalensis aqueous extract exhibits a biphasic chronotropic effect on mouse heart and a positive chronotropic activity on hiPS cell-derived CMs, suggesting a possible mechanism through muscarinic and β-adrenergic receptor pathways. Also, ESAE is not cytotoxic on mouse ES cells at concentrations up to 100 µg/mL. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Outcomes in patients with chronic kidney disease not on dialysis receiving extended dosing regimens of darbepoetin alfa: long-term results of the EXTEND observational cohort study.

PubMed

Galle, Jan-Christoph; Addison, Janet; Suranyi, Michael G; Claes, Kathleen; Di Giulio, Salvatore; Guerin, Alain; Herlitz, Hans; Kiss, István; Farouk, Mourad; Manamley, Nick; Wirnsberger, Gerhard; Winearls, Christopher

2016-12-01

Extended dosing of the erythropoiesis-stimulating agent (ESA) darbepoetin alfa (DA) once biweekly or monthly reduces anaemia treatment burden. This observational study assessed outcomes and dosing patterns in patients with chronic kidney disease not on dialysis (CKD-NoD) commencing extended dosing of DA. Adult CKD-NoD patients starting extended dosing of DA in Europe or Australia in June 2006 or later were followed up until December 2012. Outcomes included haemoglobin (Hb) concentration, ESA dosing, mortality rates and receipt of dialysis and renal transplantation. Subgroup analyses were conducted for selected outcomes. Of 6035 enrolled subjects, 5723 (94.8%) met analysis criteria; 1795 (29.7%) received dialysis and 238 (3.9%) underwent renal transplantation. Mean (standard deviation) Hb concentration at commencement of extended dosing was 11.0 (1.5) g/dL. Mean [95% confidence interval (CI)] Hb 12 months after commencement of extended dosing (primary outcome) was 11.6 g/dL (11.5, 11.6) overall and was similar across countries, with no differences between subjects previously treated with an ESA versus ESA-naïve subjects, subjects with versus without prior renal transplant or diabetics versus non-diabetics. Weekly ESA dose gradually decreased following commencement of extended DA dosing and was similar across subgroups. The decrease in weekly DA dose was accompanied by an increase in the proportion of patients receiving iron therapy. Hb concentrations declined following changes in ESA labels and treatment guidelines. The mortality rate (95% CI) was 7.06 (6.68, 7.46) deaths per 100 years of follow-up. Subjects alive at study end had stable Hb concentrations in the preceding year, while those who died had lower and declining Hb concentrations in their last year. Long-term, extended dosing of DA maintained Hb concentrations in patients already treated with an ESA and corrected and maintained Hb in ESA-naïve patients. © The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA.

iss051e049152

NASA Image and Video Library

2017-05-24

iss051e049152 (5/24/2017) --- ESA astronaut Thomas Pesquet performs the commissioning of the Gravitational References for Sensimotor Performance (GRASP) experiment, to better understand how the central nervous system (CNS) integrates information from different sensations. The data collected could help researchers better understand the workings of the human vestibular system and how it connects to the other sensory organs. This research hopes to shed light on how to best treat the loss of vestibular function on Earth.

iss051e049147

NASA Image and Video Library

2017-05-24

iss051e049147 (5/24/2017) --- ESA astronaut Thomas Pesquet performs the commissioning of the Gravitational References for Sensimotor Performance (GRASP) experiment, to better understand how the central nervous system (CNS) integrates information from different sensations. The data collected could help researchers better understand the workings of the human vestibular system and how it connects to the other sensory organs. This research hopes to shed light on how to best treat the loss of vestibular function on Earth.

How Special We Are - Biodiversity in the U.S.

DTIC Science & Technology

2004-08-01

emphasis on the ESA • Tell an interesting story • Use respected sources of information • Avoid regulatory language • Create opportunities with others...water. Great Plains Bison Black-tailed prairie dog Black-footed ferret (E) Bluestem The Continental Divide Grizzly bear (E) Mountain lion Mountain goat... us ? “Double Back” by Beverly Doolittle Maybe not for everyone… California red-legged frog (T) What of our literature and performing arts? The

Prostate Cancer Rates by Race and Ethnicity

MedlinePlus

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2013-12-23

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Hubble Feathers the Peacock

NASA Image and Video Library

2014-09-19

This picture, taken by the NASA/ESA Hubble Space Telescope’s Wide Field Planetary Camera 2 (WFPC2), shows a galaxy known as NGC 6872 in the constellation of Pavo (The Peacock). Its unusual shape is caused by its interactions with the smaller galaxy that can be seen just above NGC 6872, called IC 4970. They both lie roughly 300 million light-years away from Earth. From tip to tip, NGC 6872 measures over 500,000 light-years across, making it the second largest spiral galaxy discovered to date. In terms of size it is beaten only by NGC 262, a galaxy that measures a mind-boggling 1.3 million light-years in diameter! To put that into perspective, our own galaxy, the Milky Way, measures between 100,000 and 120,000 light-years across, making NGC 6872 about five times its size. The upper left spiral arm of NGC 6872 is visibly distorted and is populated by star-forming regions, which appear blue on this image. This may have been be caused by IC 4970 recently passing through this arm — although here, recent means 130 million years ago! Astronomers have noted that NGC 6872 seems to be relatively sparse in terms of free hydrogen, which is the basis material for new stars, meaning that if it weren’t for its interactions with IC 4970, NGC 6872 might not have been able to produce new bursts of star formation. Credit: Image credit: ESA/Hubble & NASA / Acknowledgement: Judy Schmidt NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

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Image processing for flight crew enhanced situation awareness

NASA Technical Reports Server (NTRS)

Roberts, Barry

1993-01-01

This presentation describes the image processing work that is being performed for the Enhanced Situational Awareness System (ESAS) application. Specifically, the presented work supports the Enhanced Vision System (EVS) component of ESAS.

Portrait view of ESA Spacelab Specialists

NASA Technical Reports Server (NTRS)

1978-01-01

Portrait view of European Space Agency (ESA) Spacelab Specialist Ulf Merbold in civilian clothes standing in front of a display case. The photo was taken at the Marshall Space Flight Center (MSFC), Huntsville, Alabama.

jsc2014e079941

NASA Image and Video Library

2014-09-08

PHOTO DATE: 09-08-14 LOCATION: Building 16N/1040 - SES Alpha-Cupola SUBJECT: ESA Astronaut Timothy Peake on behalf of ESA prior to FF RNDZ ADV 3 training with Kopra and Wilmore. PHOTOGRAPHER: BILL STAFFORD

jsc2014e079942

NASA Image and Video Library

2014-09-08

PHOTO DATE: 09-08-14 LOCATION: Building 16N/1040 - SES Alpha-Cupola SUBJECT: ESA Astronaut Timothy Peake on behalf of ESA prior to FF RNDZ ADV 3 training with Kopra and Wilmore. PHOTOGRAPHER: BILL STAFFORD

Kuipers in ATV3

NASA Image and Video Library

2012-05-15

ISS031-E-157790 (15 May 2012) --- European Space Agency astronaut Andre Kuipers, Expedition 31 flight engineer, floats freely in ESA?s "Edoardo Amaldi" Automated Transfer Vehicle-3 (ATV-3) currently docked with the International Space Station.

Identification of a new sulfonic acid metabolite of metolachlor in soil

USGS Publications Warehouse

Aga, D.S.; Thurman, E.M.; Yockel, M.E.; Zimmerman, L.R.; Williams, T.D.

1996-01-01

An ethanesulfonic acid metabolite of metolachlor (metolachlor ESA) was identified in soil-sample extracts by negative-ion, fast-atom bombardment mass spectrometry (FAB-MS) and FAB tandem mass spectrometry (FAB-MS/MS). Production fragments from MS/MS analysis of the deprotonated molecular ion of metolachlor ESA in the soil extract can be reconciled with the structure of the synthesized standard. The elemental compositions of the (M - H)- ions of the metolachlor ESA standard and the soil-sample extracts were confirmed by high-resolution mass spectrometry. A dissipation study revealed that metolachlor ESA is formed in soil under field conditions corresponding to a decrease in the concentration of the parent herbicide, metolachlor. The identification of the sulfonated metabolite of metolachlor suggests that the glutathione conjugation pathway is a common detoxification pathway shared by chloroacetanilide herbicides.

Space strategy and governance of ESA small member states

NASA Astrophysics Data System (ADS)

Sagath, Daniel; Papadimitriou, Angeliki; Adriaensen, Maarten; Giannopapa, Christina

2018-01-01

The European Space Agency (ESA) has twenty-two Member States with a variety of governance structures and strategic priorities regarding their space activities. The objective of this paper is to provide an up-to date overview and a holistic assessment of the national space governance structures and strategic priorities of the eleven smaller Member States (based on annual ESA contributions). A link is made between the governance structure and the main strategic objectives. The specific needs and interests of small and new Member States in the frame of European Space Integration are addressed. The first part of the paper focuses on the national space governance structures in the eleven smaller ESA Member States. The governance models of these Member States are identified including the responsible ministries and the entities entrusted with the implementation of space strategy/policy and programmes of the country. The second part of this paper focuses on the content and analysis of the national space strategies and indicates the main priorities and trends in the eleven smaller ESA Member States. The priorities are categorised with regards to technology domains, the role of space in the areas of sustainability and the motivators for space investments. In a third and final part, attention is given to the specific needs and interests of the smaller Member States in the frame of European space integration. ESA instruments are tailored to facilitate the needs and interests of the eleven smaller and/or new Member States.

Anemia in conventional hemodialysis: Finding the optimal treatment balance.

PubMed

Hasegawa, Takeshi; Koiwa, Fumihiko; Akizawa, Tadao

2018-06-17

Renal anemia is a serious and common complication in hemodialysis (HD) patients. The introduction of erythropoiesis-stimulating agents (ESAs) has dramatically improved hemoglobin levels and outcomes. Several interventional studies reported that excessive correction of anemia and the massive use of ESA can trigger cardiovascular disease (CVD), and consequently may worsen the prognosis of patients undergoing HD. Therefore, it has been widely recognized that large doses of ESA should be used with caution. An effective use of iron preparations is required to yield the optimal effect of ESA. It is well-known that iron utilization is inhibited under pathological conditions, such as chronic inflammation, resulting in ESA resistance. It is postulated that a new class of therapeutic agents for renal anemia, hypoxia inducible factor prolyl hydroxylase (HIF-PH) inhibitors, will have beneficial treatment effects in patients on HD. HIF is induced by hypoxia and promotes erythropoietin production. In the absence of a hypoxic state, HIF is decomposed by the HIF catabolic enzyme. HIF-PH inhibitors inhibit this degrading enzyme and stimulate endogenous erythropoietin production via HIF induction. Additionally, HIF-PH inhibitors promote effective utilization of iron and raise erythropoietin to physiological concentrations. Accordingly, HIF-PH inhibitors improve anemia and iron metabolism. It appears that this effect persists irrespective of chronic inflammatory conditions. HIF-PH inhibitors do not overshoot erythropoietin above physiological concentrations like ESAs. Therefore, it is hypothesized that HIF-PH inhibitors would not increase the risk of CVD in patients undergoing HD. © 2018 Wiley Periodicals, Inc.

ECLIPSE, an Emerging Standardized Modular, Secure and Affordable Software Toolset in Support of Product Assurance, Quality Assurance and Project Management for the Entire European Space Industry (from Innovative SMEs to Primes and Institutions)

NASA Astrophysics Data System (ADS)

Bennetti, Andrea; Ansari, Salim; Dewhirst, Tori; Catanese, Giuseppe

2010-08-01

The development of satellites and ground systems (and the technologies that support them) is complex and demands a great deal of rigor in the management of both the information it relies upon and the information it generates via the performance of well established processes. To this extent for the past fifteen years Sapienza Consulting has been supporting the European Space Agency (ESA) in the management of this information and provided ESA with ECSS (European Cooperation for Space Standardization) Standards based Project Management (PM), Product Assurance (PA) and Quality Assurance (QA) software applications. In 2009 Sapienza recognised the need to modernize, standardizing and integrate its core ECSS-based software tools into a single yet modularised suite of applications named ECLIPSE aimed at: • Fulfilling a wider range of historical and emerging requirements, • Providing a better experience for users, • Increasing the value of the information it collects and manages • Lowering the cost of ownership and operation • Increasing collaboration within and between space sector organizations • Aiding in the performance of several PM, PA, QA, and configuration management tasks in adherence to ECSS standards. In this paper, Sapienza will first present the toolset, and a rationale for its development, describing and justifying its architecture, and basic modules composition. Having defined the toolset architecture, this paper will address the current status of the individual applications. A compliance assessment will be presented for each module in the toolset with respect to the ECSS standard it addresses. Lastly experience from early industry and Institutional users will be presented.

"Europe lands on Mars" - Media event at ESA/ESOC

NASA Astrophysics Data System (ADS)

2003-11-01

Launched on 2 June 2003 from Baikonur (Kazakhstan) on board a Russian Soyuz operated by Starsem, the European probe - built for ESA by a European team of industrial companies led by Astrium - carries seven scientific instruments that will perform a series of remote-sensing experiments designed to shed new light on the Martian atmosphere, the planet's structure and its geology. In particular, the British-made Beagle 2 lander will contribute to the search for traces of life on Mars through exobiology experiments and geochemistry research. On board Mars Express tests have been run to check that the instruments are functioning correctly. Mars Express has successfully come through its first power test on the whole spacecraft after the gigantic solar flare on 28 October. Since 17 November the onboard software has been 'frozen' after several updates and the spacecraft is now quietly proceeding to its destination. Before even entering into Martian orbit to perform its mission, Mars Express has to face another challenge: safely delivering the Beagle 2 lander to its destination. This task, starting on 19 December, will not be without risk. First of all, to deliver the lander where planned, Mars Express has been put on a collision course with Mars, since Beagle 2 does not have a propulsion system of its own and must therefore be 'carried' precisely to its destination. This means that after separation, Mars Express has to veer away quickly to avoid crashing onto the planet. During the cruise Beagle 2 will take its power from the mother spacecraft, Mars Express. After separation and until its solar arrays are fully deployed on the surface, Beagle 2 must rely on its own battery, which cannot last beyond 6 days. So, like a caring parent, Mars Express must release Beagle 2 at the last possible moment to ensure that the lander has enough power for the rest of its journey to the surface. Only then can Mars Express change its orientation and rapidly fire the thrusters to get away from the collision course and enter into orbit around Mars. This will be the first time that an orbiter delivers a lander without its own propulsion onto a planet and attempts orbit insertion immediately afterwards. Since all these manoeuvres are time-critical and allow little margin of error, the ground control team has had to simulate all possible scenarios (including glitches and problems, on board and on the ground) to make sure that nothing is left to chance. The team has been training since September in a very realistic setting, using the same computers and equipment that will be employed during this mission phase. Although the real spacecraft cannot be directly involved, its behaviour is simulated via a sophisticated computer programme, using the actual flight software. These rehearsals, each lasting a day or more, cover all possible situations from the failure of an onboard instrument to the outbreak of a fire in the control room. One of these simulations will take place during the press conference on 3 December. ESA's ground control team at ESOC, on the other hand, are having a very busy time. They are actively rehearsing responses to any situation that might arise when Mars Express releases Beagle 2 and enters into orbit around Mars. "The Mars Express mission is pushing the operations staff to extremes. Over the years, the experience acquired with experimental missions has provided a solid basis on which to prepare for the unexpected. The satellite controllers will rise to this new challenge", Gaele Winters, ESA Director of Technical and Operational Support, said. Four media events have been scheduled relating to the arrival of Mars Express at its destination (see our press release N° 74-2003). The next event is scheduled on Wednesday 3 December at ESA/ESOC, Darmstadt, Germany and will possibly include the presentation of the first HRSC image and further information about scientific expectations of the mission. Several Principal Investigators will present their instruments and early results of testing and operations (see programme attached). A videoconference of this ESA media briefing will be organised at ESA/Headquarters, Paris (F), ESA/ESTEC, Noordwijk (NL) and ESA/ESRIN, Frascati (I). Media wishing to attend are asked to complete the attached reply form and fax it to the Communication Office at the establishment of their choice. Throughout December you can follow daily the countdown to arrival at Mars on the web at : http://mars.esa.int Here you will find live streaming of key events, news, features, images, videos and more.

Insights regarding the Usefulness of Partial Notes in Mathematics Courses

ERIC Educational Resources Information Center

Cardetti, Fabiana; Khamsemanan, Nirattaya; Orgnero, M. Carolina

2010-01-01

Note-taking is a widespread practice used by college students to record information from lectures. Unfortunately, even successful students' notes are incomplete and, therefore, may lack the potential to positively impact their academic performance. Research suggests that instructors can help students improve their note-taking skills by using…

The europa initiative for esa's cosmic vision: a potential european contribution to nasa's Europa mission

NASA Astrophysics Data System (ADS)

Blanc, Michel; Jones, Geraint H.; Prieto-Ballesteros, Olga; Sterken, Veerle J.

2016-04-01

The assessment of the habitability of Jupiter's icy moons is considered of high priority in the roadmaps of the main space agencies, including the decadal survey and esa's cosmic vision plan. the voyager and galileo missions indicated that europa and ganymede may meet the requirements of habitability, including deep liquid aqueous reservoirs in their interiors. indeed, they constitute different end-terms of ocean worlds, which deserve further characterization in the next decade. esa and nasa are now both planning to explore these ice moons through exciting and ambitious missions. esa selected in 2012 the juice mission mainly focused on ganymede and the jupiter system, while nasa is currently studying and implementing the europa mission. in 2015, nasa invited esa to provide a junior spacecraft to be carried on board its europa mission, opening a collaboration scheme similar to the very successful cassini-huygens approach. in order to define the best contribution that can be made to nasa's europa mission, a europa initiative has emerged in europe. its objective is to elaborate a community-based strategy for the proposition of the best possible esa contribution(s) to nasa's europa mission, as a candidate for the upcoming selection of esa's 5th medium-class mission . the science returns of the different potential contributions are analysed by six international working groups covering complementary science themes: a) magnetospheric interactions; b) exosphere, including neutrals, dust and plumes; c) geochemistry; d) geology, including expressions of exchanges between layers; e) geophysics, including characterization of liquid water distribution; f) astrobiology. each group is considering different spacecraft options in the contexts of their main scientific merits and limitations, their technical feasibility, and of their interest for the development of esa-nasa collaborations. there are five options under consideration: (1) an augmented payload to the europa mission main spacecraft itself. (2) a free-flyer released from the main craft and staying on a jupiter orbit. (3) a small autonomous satellite injected into europan orbit. (4) a penetrator of europa's surface (including instrumentation on the descent module). (5) contributions to a soft lander, if developed by nasa in an increased europa mission scenario. in this talk we will report on the conclusions of the crossed analysis between science themes and spacecraft options performed during a dedicated project workshop held in madrid on feb. 29 and march 1st, which will be the scientific and technical base for any relevant europa-related response to the upcoming esa call.

M-AMST: an automatic 3D neuron tracing method based on mean shift and adapted minimum spanning tree.

PubMed

Wan, Zhijiang; He, Yishan; Hao, Ming; Yang, Jian; Zhong, Ning

2017-03-29

Understanding the working mechanism of the brain is one of the grandest challenges for modern science. Toward this end, the BigNeuron project was launched to gather a worldwide community to establish a big data resource and a set of the state-of-the-art of single neuron reconstruction algorithms. Many groups contributed their own algorithms for the project, including our mean shift and minimum spanning tree (M-MST). Although M-MST is intuitive and easy to implement, the MST just considers spatial information of single neuron and ignores the shape information, which might lead to less precise connections between some neuron segments. In this paper, we propose an improved algorithm, namely M-AMST, in which a rotating sphere model based on coordinate transformation is used to improve the weight calculation method in M-MST. Two experiments are designed to illustrate the effect of adapted minimum spanning tree algorithm and the adoptability of M-AMST in reconstructing variety of neuron image datasets respectively. In the experiment 1, taking the reconstruction of APP2 as reference, we produce the four difference scores (entire structure average (ESA), different structure average (DSA), percentage of different structure (PDS) and max distance of neurons' nodes (MDNN)) by comparing the neuron reconstruction of the APP2 and the other 5 competing algorithm. The result shows that M-AMST gets lower difference scores than M-MST in ESA, PDS and MDNN. Meanwhile, M-AMST is better than N-MST in ESA and MDNN. It indicates that utilizing the adapted minimum spanning tree algorithm which took the shape information of neuron into account can achieve better neuron reconstructions. In the experiment 2, 7 neuron image datasets are reconstructed and the four difference scores are calculated by comparing the gold standard reconstruction and the reconstructions produced by 6 competing algorithms. Comparing the four difference scores of M-AMST and the other 5 algorithm, we can conclude that M-AMST is able to achieve the best difference score in 3 datasets and get the second-best difference score in the other 2 datasets. We develop a pathway extraction method using a rotating sphere model based on coordinate transformation to improve the weight calculation approach in MST. The experimental results show that M-AMST utilizes the adapted minimum spanning tree algorithm which takes the shape information of neuron into account can achieve better neuron reconstructions. Moreover, M-AMST is able to get good neuron reconstruction in variety of image datasets.

Patient preference to use a questionnaire varies according to attributes.

PubMed

Kim, Na Yae; Richardson, Lyndsay; He, Weilin; Jones, Glenn

2011-08-01

Health care professionals may assume questionnaires are burdensome to patients, and this limits their use in clinical settings and promotes simplification. However, patient adherence may improve by optimizing questionnaire attributes and contexts. This cross-sectional survey used Contingent Valuation methods to directly elicit patient preference for conventional monitoring of symptoms, versus adding a tool to monitoring. Under explicit consideration was the 10-question Edmonton Symptom Assessment System (ESAS). In the questionnaire, attributes of ESAS were sequentially altered to try and force preference reversal. A separate group of participants completed both questionnaire and interviews to explore questionnaire reliability, and extend validity. Overall, 24 of 43 participants preferred using ESAS. Most important attributes to preference were frequency, specificity, and complexity. Where preference is initially against ESAS, it may reverse by simplifying the tool and its administrative processes. Interviews in 10 additional participants supported reproducibility and validity of the questionnaire method. Preference for using tools increases when tools are made relevant and used more appropriately. Questionnaires completed by patients as screening tools or aids to communication may be under-utilized. Optimization of ESAS and similar tools may be guided by empirical findings, including those obtained from Contingent Valuation methodologies. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

An overview on safety issues related to erythropoiesis-stimulating agents for the treatment of anaemia in patients with chronic kidney disease.

PubMed

Del Vecchio, Lucia; Locatelli, Francesco

2016-08-01

Erythropoiesis stimulating agents (ESA) are effective drugs, which have been used for decades in patients with chronic kidney disease (CKD) with few side effects. More recently, concern has been raised around their safety, from higher cardiovascular and thrombosis risk to cancer progression and increased mortality. We made a literature search on PubMed looking for adverse effects of ESA in CKD patients. The topics covered are cardiovascular adverse events, thrombosis, increased mortality, hypertension, cancer progression, diabetic retinopathy, pure red cell aplasia and anaphylactic reactions. Concerns around ESA therapy have questioned treatment indications in high-risk CKD patients (those with cancer, diabetes and cardiovascular comorbidities). A more cautious approach has then prevailed. In our opinion, intermediate Hb values (Hb 10-12 g/dl) should be aimed with ESA therapy, being more cautious in high-risk patients. As a consequence, IV iron is administered more frequently. However, excessive iron use may cause iron overload and in rare cases severe anaphylactic reactions. There are expectations of new erythropoietic agents, such as those manipulating the hypoxia-inducible transcription factors (HIF) system. Differing from ESAs, they stimulate the production of endogenous EPO, avoiding over-physiological plasmatic levels.

Excited-state absorption in Er: BaY2F8 and Cs3Er2Br9 and comparison with Er: LiYF4

NASA Astrophysics Data System (ADS)

Pollnau, M.; Lüthy, W.; Weber, H. P.; Krämer, K.; Güdel, H. U.; McFarlane, R. A.

1996-04-01

The influence of Excited-State Absorption (ESA) on the green laser transition and the overlap of Ground-State Absorption (GSA) and ESA for 970 nm upconversion pumping in erbium is investigated in Er3+ : BaY2F8 and Cs3Er2Br9. Results are compared to Er3+ : LiYF4. In Er3+: BaY2F8, a good overlap between GSA and ESA is found at 969 nm in one polarization direction. The emission cross section at 550 nm is a factor of two smaller than in LiYF4. In Cs3Er2Br9, the smaller Stark splitting of the levels shifts the wavelengths of the green emission and ESA from4 I 1 3/2 off resonance. It enhances, however, ground-state reabsorption. The emission cross section at 550 nm is comparable to LiYF4. Upconversion leads to significant green fluorescence from2 H 9/2. A significant population of the4 I 11/2 level and ESA at 970 nm are not present under 800 nm pumping.

Ethanesulfonic acid-based esterification of industrial acidic crude palm oil for biodiesel production.

PubMed

Hayyan, Adeeb; Mjalli, Farouq S; Hashim, Mohd Ali; Hayyan, Maan; AlNashef, Inas M; Al-Zahrani, Saeed M; Al-Saadi, Mohammed A

2011-10-01

An industrial grade acidic crude palm oil (ACPO) pre-treatment process was carried out using ethanesulfonic acid (ESA) as a catalyst in the esterification reaction. ESA was used in different dosages to reduce free fatty acid (FFA) to a minimum level for the second stage of biodiesel production via alkaline transesterification reaction. Different process operating conditions were optimized such as ESA dosage (0.25-3.5% wt/wt), methanol to ACPO molar ratio (1:1-20:1), reaction temperature (40-70 °C), and reaction time (3-150 min). This study revealed the potential use of abundant quantities of ACPO from oil palm mills for biodiesel production. The lab scale results showed the effectiveness of the pre-treatment process using ESA catalyst. Three consecutive catalyst recycling runs were achieved without significant degradation in its performance. Second and third reuse runs needed more reaction time to achieve the target level of FFA content. Esterification and transesterification using ESA and KOH respectively is proposed for biodiesel industrial scale production. The produced biodiesel meets the international standards specifications for biodiesel fuel (EN 14214 and ASTM D6751). Copyright © 2011 Elsevier Ltd. All rights reserved.

ESA seeks gravitational-wave proposals

NASA Astrophysics Data System (ADS)

Banks, Michael

2016-12-01

The European Space Agency (ESA) has put out a call for European scientists to submit proposals for the first space mission to observe gravitational waves - ripples in the fabric of space-time created by accelerating massive objects.

Biology Notes.

ERIC Educational Resources Information Center

School Science Review, 1984

1984-01-01

Presents information on the teaching of nutrition (including new information relating to many current O-level syllabi) and part 16 of a reading list for A- and S-level biology. Also includes a note on using earthworms as a source of material for teaching meiosis. (JN)

Performance of the rebuilt SUERC single-stage accelerator mass spectrometer

NASA Astrophysics Data System (ADS)

Shanks, Richard P.; Ascough, Philippa L.; Dougans, Andrew; Gallacher, Paul; Gulliver, Pauline; Rood, Dylan H.; Xu, Sheng; Freeman, Stewart P. H. T.

2015-10-01

The SUERC bipolar single-stage accelerator mass spectrometer (SSAMS) has been dismantled and rebuilt to accommodate an additional rotatable pre-accelerator electrostatic spherical analyser (ESA) and a second ion source injector. This is for the attachment of an experimental positive-ion electron cyclotron resonance (ECR) ion source in addition to a Cs-sputter source. The ESA significantly suppresses oxygen interference to radiocarbon detection, and remaining measurement interference is now thought to be from 13C injected as 13CH molecule scattering off the plates of a second original pre-detector ESA.

Darbepoetin Administration in Term and Preterm Neonates.

PubMed

Patel, Shrena; Ohls, Robin K

2015-09-01

Erythropoiesis-stimulating agents (ESAs) such as erythropoietin have been studied as red cell growth factors in preterm and term infants for more than 20 years. Recent studies have evaluated darbepoetin (Darbe, a long-acting ESA) for both erythropoietic effects and potential neuroprotection. We review clinical trials of Darbe in term and preterm infants, which have reported significant erythropoietic uses and neuroprotective effects. ESAs show great promise in decreasing or eliminating transfusions, and in preventing and treating brain injury in term and preterm infants. Copyright © 2015 Elsevier Inc. All rights reserved.

ATV2 launch views

NASA Image and Video Library

2011-02-16

JSC2011-E-017489 (16 Feb. 2011) --- The Ariane 5 rocket is pictured just after lift off from Europe?s Spaceport in Kourou, French Guiana. ESA?s second Automated Transfer Vehicle, Johannes Kepler, was just a short time earlier (21:50 GMT or 18:50 Kourou time on Feb. 16, 2011) launched toward its targeted low orbit and eventual link-up with the ISS. The unmanned supply ship is planned to deliver critical supplies and reboost the space station during its almost four-month mission. Photo courtesy of ESA/Stephane Corvaja and P. Baudon

A Note on the Equivalence between Observed and Expected Information Functions with Polytomous IRT Models

ERIC Educational Resources Information Center

Magis, David

2015-01-01

The purpose of this note is to study the equivalence of observed and expected (Fisher) information functions with polytomous item response theory (IRT) models. It is established that observed and expected information functions are equivalent for the class of divide-by-total models (including partial credit, generalized partial credit, rating…

The ISOPHOT 170 μm Serendipity Survey. IV. The far-infrared sky atlas

NASA Astrophysics Data System (ADS)

Stickel, M.; Krause, O.; Klaas, U.; Lemke, D.

2007-05-01

Aims:To further increase the scientific utilization of the strip scanning measurements of the ISOPHOT Serendipity Survey (ISOSS), the slew data has been assembled to a sky atlas with ≈15% sky coverage in the hitherto unobserved far-infrared wavelength band around 170 μm. Methods: The redundant information of the brightnesses at slew crossings has been used to globally rescale and homogenize the slew brightnesses, leading to significantly increased photometric accuracy and reproducibility as well as the homogeneity of the maps. The corrected slew data were mapped with a constant grid size of 22.4 arcsec and are presented in 124 maps in galactic coordinates. Results: The collection of image plates represents the ISOSS Sky Atlas, which will become available from major data archives. Exemplary scientific results are described, which show the scientific potential of the data set combined with far-infrared imaging data from previous and upcoming missions. Based on observations with ISO, an ESA project with instruments funded by ESA Member States (especially the PI countries: France, Germany, The Netherlands and the United Kingdom) and with the participation of ISAS and NASA. Members of the Consortium on the ISOPHOT Serendipity Survey (CISS) are MPIA Heidelberg, ESAC Villafranca, AIP Potsdam, IPAC Pasadena, Imperial College London. Image files (FITS files) are available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/466/1205 and the ISO Data Archive www.iso.vilspa.esa.es/

EGSE customization for the Euclid NISP Instrument AIV/AIT activities

NASA Astrophysics Data System (ADS)

Franceschi, E.; Trifoglio, M.; Gianotti, F.; Conforti, V.; Andersen, J. J.; Stephen, J. B.; Valenziano, L.; Auricchio, N.; Bulgarelli, A.; De Rosa, A.; Fioretti, V.; Maiorano, E.; Morgante, G.; Nicastro, L.; Sortino, F.; Zoli, A.; Balestra, A.; Bonino, D.; Bonoli, C.; Bortoletto, F.; Capobianco, V.; Corcione, L.; Dal Corso, F.; Debei, S.; Di Ferdinando, D.; Dusini, S.; Farinelli, R.; Fornari, F.; Giacomini, F.; Guizzo, G. P.; Laudisio, F.; Ligori, S.; Mauri, N.; Medinaceli, E.; Patrizii, L.; Sirignano, C.; Sirri, G.; Stanco, L.; Tenti, M.; Valieri, C.; Ventura, S.

2016-07-01

The Near Infrared Spectro-Photometer (NISP) on board the Euclid ESA mission will be developed and tested at various levels of integration by using various test equipment. The Electrical Ground Support Equipment (EGSE) shall be required to support the assembly, integration, verification and testing (AIV/AIT) and calibration activities at instrument level before delivery to ESA, and at satellite level, when the NISP instrument is mounted on the spacecraft. In the case of the Euclid mission this EGSE will be provided by ESA to NISP team, in the HW/SW framework called "CCS Lite", with a possible first usage already during the Warm Electronics (WE) AIV/AIT activities. In this paper we discuss how we will customize that "CCS Lite" as required to support both the WE and Instrument test activities. This customization will primarily involve building the NISP Mission Information Base (the CCS MIB tables) by gathering the relevant data from the instrument sub-units and validating these inputs through specific tools. Secondarily, it will imply developing a suitable set of test sequences, by using uTOPE (an extension to the TCL scripting language, included in the CCS framework), in order to implement the foreseen test procedures. In addition and in parallel, custom interfaces shall be set up between the CCS and the NI-IWS (the NISP Instrument Workstation, which will be in use at any level starting from the WE activities), and also between the CCS and the TCC (the Telescope Control and command Computer, to be only and specifically used during the instrument level tests).

Using Medical Text Extraction, Reasoning and Mapping System (MTERMS) to Process Medication Information in Outpatient Clinical Notes

PubMed Central

Zhou, Li; Plasek, Joseph M; Mahoney, Lisa M; Karipineni, Neelima; Chang, Frank; Yan, Xuemin; Chang, Fenny; Dimaggio, Dana; Goldman, Debora S.; Rocha, Roberto A.

2011-01-01

Clinical information is often coded using different terminologies, and therefore is not interoperable. Our goal is to develop a general natural language processing (NLP) system, called Medical Text Extraction, Reasoning and Mapping System (MTERMS), which encodes clinical text using different terminologies and simultaneously establishes dynamic mappings between them. MTERMS applies a modular, pipeline approach flowing from a preprocessor, semantic tagger, terminology mapper, context analyzer, and parser to structure inputted clinical notes. Evaluators manually reviewed 30 free-text and 10 structured outpatient clinical notes compared to MTERMS output. MTERMS achieved an overall F-measure of 90.6 and 94.0 for free-text and structured notes respectively for medication and temporal information. The local medication terminology had 83.0% coverage compared to RxNorm’s 98.0% coverage for free-text notes. 61.6% of mappings between the terminologies are exact match. Capture of duration was significantly improved (91.7% vs. 52.5%) from systems in the third i2b2 challenge. PMID:22195230

Capacity building in Developing Countries: a challenge ahead for the European Space Agency to continue its successful experience to date

NASA Astrophysics Data System (ADS)

Fea, M.

The European Space Agency (ESA) has built a long tradition and a large experience in the domain of education, training and capacity building throughout its space programmes. As an example, the ESA Science Programme dedicates 1% of its budget to these activities. One of the key reasons for it is the need of closing the loop along the chain from the provider to the user, that is to say between the space and the users elements. In fact, besides the obvious need for technology development, there is actually not very much justification in the long term for a space programme if the user communities are not able to make good use of programme outputs and provide feedback and proper requirements to space agencies. The case of ESA Earth Observation programmes is described to illustrate these considerations, as a way to also implement the European Space Policy and UNISPACE III recommendations. Since its foundation in 1975 and the implementation of its EO programme with the launch of Meteosat-1 in 1977 and the birth of the Earthnet Programme Office in 1978, the European Space Agency is very active in the field of capacity building in developing countries. That is performed through both ESA's specific projects and international co-operation activities. In the latter domain, ESA enjoys a long-standing collaboration with many entities, such as the Committee of Earth Observation Satellites (CEOS), and organisations, such as WMO, UN and its specialised agencies (FAO, UNESCO, UNEP, and so on). In that respect, the Agency is an active member of the CEOS Working Group on Education (WGEdu) and of the World Summit for Sustainable Development Follow-Up (WSSD) Module 1 group dedicated to education, training and capacity building. The overall ESA strategy targets various citizen communities and takes into account the fact that today's young generations will become tomorrow's professionals and decision makers. ESA's activities in this domain are in particular based on an end-to-end concept that includes a) the "train the trainer" approach, b) the prerequisite of a project proposal prepared by the trainee of a target institution on an issue of, possibly, national interest and focused towards establishing an operational autonomy and a routine practice in the integration and use of EO satellite data, c) the firm commitment of the institution to support the project and the trainee, d) the involvement of final users since the very beginning, and e) the exposure of trainees to public for presenting their results. In order to demonstrate how the Agency implements all the above, besides the typical training of external satellite ground station operators, and the way ahead strategy considered within the CEOS WGEdu and WSSD Mod.1 framework, three ESA endeavours are presented, namely the multi-language EDUSPACE web portal (www.eduspace.esa.int), the hosting of UN trainees, and the UN/ESA Course Follow-up Programme.

Historical clinical and economic consequences of anemia management in patients with end-stage renal disease on dialysis using erythropoietin stimulating agents versus routine blood transfusions: a retrospective cost-effectiveness analysis.

PubMed

Naci, Huseyin; de Lissovoy, Gregory; Hollenbeak, Christopher; Custer, Brian; Hofmann, Axel; McClellan, William; Gitlin, Matthew

2012-01-01

To determine whether Medicare's decision to cover routine administration of erythropoietin stimulating agents (ESAs) to treat anemia of end-stage renal disease (ESRD) has been a cost-effective policy relative to standard of care at the time. The authors used summary statistics from the actual cohort of ESRD patients receiving ESAs between 1995 and 2004 to create a simulated patient cohort, which was compared with a comparable simulated cohort assumed to rely solely on blood transfusions. Outcomes modeled from the Medicare perspective included estimated treatment costs, life-years gained, and quality-adjusted life-years (QALYs). Incremental cost-effectiveness ratio (ICER) was calculated relative to the hypothetical reference case of no ESA use in the transfusion cohort. Sensitivity of the results to model assumptions was tested using one-way and probabilistic sensitivity analyses. Estimated total costs incurred by the ESRD population were $155.47B for the cohort receiving ESAs and $155.22B for the cohort receiving routine blood transfusions. Estimated QALYs were 2.56M and 2.29M, respectively, for the two groups. The ICER of ESAs compared to routine blood transfusions was estimated as $873 per QALY gained. The model was sensitive to a number of parameters according to one-way and probabilistic sensitivity analyses. This model was counter-factual as the actual comparison group, whose anemia was managed via transfusion and iron supplements, rapidly disappeared following introduction of ESAs. In addition, a large number of model parameters were obtained from observational studies due to the lack of randomized trial evidence in the literature. This study indicates that Medicare's coverage of ESAs appears to have been cost effective based on commonly accepted levels of willingness-to-pay. The ESRD population achieved substantial clinical benefit at a reasonable cost to society.

Simplifying anemia management in hemodialysis patients: ESAs administered at longer dosing intervals can enhance opportunities to provide patient-focused care.

PubMed

Schiller, Brigitte; Besarab, Anatole

2011-08-01

To review issues and challenges in caring for hemodialysis patients with anemia of chronic kidney disease, specifically focusing on the effects of longer erythropoiesis-stimulating agent (ESA) dosing intervals on processes of care. PubMed searches were performed limited to the last 10 years to February 2011, focusing on articles in English that were 'clinical trials,' assessed processes of care, measured associations of hemoglobin (Hb) with outcomes, and explored/analyzed extended dosing intervals of ESAs in hemodialysis patients and recommendations for increasing the quality of care of these patients. Some limitations included the fact that a meta-analysis was not conducted; many studies were associative and therefore unable to prove causality; and none of the clinical trials directly compared the impact of more frequent or less frequent ESA dosing strategies on patient care and outcomes. Progress over the past several decades has been substantial; however, unmet needs remain and there is room for improvement in efficiencies of care. Many patients fail to meet Hb targets, and nephrology professionals' time is consumed with preparing, administering, and monitoring therapy. Direct interaction between patients and care providers has been lost as attention has shifted to 'cost-effective' (not necessarily patient-centered) ways to deliver care. Use of ESAs at longer dosage intervals represents one opportunity to improve efficiency of care. Newer ESAs have been developed for less frequent dosing. Once-monthly dosing decreases time spent administering/monitoring therapy and allows nephrology professionals to provide comprehensive renal care, wherein the patient rather than task-oriented processes becomes the primary focus. A fragmented, uncoordinated care-delivery model heightens the urgency to systematically address issues related to delivery of care and improve efficiencies in anemia management as part of the patient-centered approach. ESAs designed for administration at longer intervals may effectively and reliably achieve Hb targets with once-monthly dosing, thereby decreasing time spent administering/monitoring therapy.

Exomars 2018 Rover Pasteur Payload Sample Analysis

NASA Astrophysics Data System (ADS)

Debus, Andre; Bacher, M.; Ball, A.; Barcos, O.; Bethge, B.; Gaubert, F.; Haldemann, A.; Kminek, G.; Lindner, R.; Pacros, A.; Rohr, T.; Trautner, R.; Vago, J.

The ExoMars programme is a joint ESA-NASA program having exobiology as one of the key science objectives. It is divided into 2 missions: the first mission is ESA-led with an ESA orbiter and an ESA Entry, Descent and Landing (EDL) demonstrator, launched in 2016 by NASA, and the second mission is NASA-led, launched in 2018 by NASA including an ESA rover and a NASA rover both deployed by a single NASA EDL system. For ESA, the ExoMars programme will demonstrate key flight and in situ enabling technologies in support of the European ambitions for future exploration missions, as outlined in the Aurora Declaration. The ExoMars 2018 ESA Rover will carry a comprehensive and coherent suite of analytical instruments dedicated to exobiology and geology research: the Pasteur Payload (PPL). This payload includes a selection of complementary instruments, having the following goals: to search for signs of past and present life on Mars and to investigate the water/geochemical environment as a function of depth in the shallow subsurface. The ExoMars Rover will travel several kilometres searching for sites warranting further investigation. The Rover includes a drill and a Sample Preparation and Distribution System which will be used to collect and analyse samples from within outcrops and from the subsurface. The Rover systems and instruments, in particular those located inside the Analytical Laboratory Drawer must meet many stringent requirements to be compatible with exobiologic investigations: the samples must be maintained in a cold and uncontaminated environment, requiring sterile and ultraclean preparation of the instruments, to preserve volatile materials and to avoid false positive results. The value of the coordinated observations suggests that a significant return on investment is to be expected from this complex development. We will present the challenges facing the ExoMars PPL, and the plans for sending a robust exobiology laboratory to Mars in 2018.

Development of a French Version of the Edmonton Symptom Assessment System-Revised: A Pilot Study of Palliative Care Patients' Perspectives.

PubMed

Nekolaichuk, Cheryl; Huot, Ann; Gratton, Valérie; Bush, Shirley H; Tarumi, Yoko; Watanabe, Sharon M

2017-09-01

The Edmonton Symptom Assessment System-revised (ESAS-r) is a nine-item self-report symptom intensity tool developed for palliative care patients, with the option of adding a 10th patient-specific symptom. Due to growing international uptake, the ESAS-r has been translated into different languages. There has not been agreement, however, regarding a standard process for translation into multiple languages, which also includes patients' perspectives. The purpose of this study was to develop a French version of the ESAS-r, using a standardized translation protocol, and to obtain palliative care patients' perspectives regarding this translated tool. We developed a French version of the ESAS-r, using a standard translation method, involving both professional translators (n = 2) and bilingual palliative care experts (n = 3). Fifteen Francophone participants recruited from palliative care sites in two urban centers in Canada completed the ESAS-r and provided feedback on the translation, in the presence of a trained interviewer. Descriptive statistics and thematic analysis were used to analyze the quantitative and qualitative data, respectively. Fifteen Francophone participants were recruited from palliative care sites in two urban centers in Canada. Participants completed the ESAS-r and provided feedback on the translation in the presence of a trained interviewer. Descriptive statistics and thematic analysis were used to analyze the quantitative and qualitative data, respectively. Based on participants' concerns, translations for four of the nine symptoms were revised: drowsiness, nausea, lack of appetite, and shortness of breath. Concerns expressed for three additional symptoms (depression, anxiety, and well-being) were related to overall difficulty rating these symptoms, not specific to the translation. The French version of the ESAS-r is a credible tool for symptom assessment in Francophone patients. The study findings provide a vital step in the development of a standardized translation protocol, including patients' perspectives, which can be applied to other languages.

77 FR 1669 - Endangered and Threatened Species; Recovery Plan for the Southern California Steelhead Distinct...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-11

... Plan identifies substantive recovery actions needed to achieve recovery by addressing the systemic... consistent approach to section 7 consultations under the ESA and to other ESA decisions. For example, the...

Note-taking in the employment interview: effects on recall and judgments.

PubMed

Middendorf, Catherine Houdek; Macan, Therese Hoff

2002-04-01

Although note-taking in the employment interview is highly recommended, little research has examined its effects. This study investigated the effects of note-taking styles, review of the notes, and content of the notes on participants' cued recall of information and decisions made from videotaped employment interviews. Note-taking increased recall accuracy but not judgment accuracy. Being able to review notes resulted in increased judgment accuracy for those taking conventional-style notes. The content of the notes also had important implications for conventional note-takers, suggesting some benefits of recording notes using the key-points style. The findings suggest that the act of note-taking may be more important for memory and legal reasons than for improving the decisions made by interviewers.

ESA study of XEUS, a potential follow-on to XMM-Newton

NASA Astrophysics Data System (ADS)

Rando, N.; Lyngvi, A.; Gondoin, P.; Lumb, D.; Bavdaz, M.; Verhoeve, P.; de Wilde, D.; Parmar, A.; Peacock, A.

2017-11-01

In October 2005, based on a massive response by the Science Community to ESA's call for themes in space science, a large aperture X-ray Observatory (XRO) was identified as a candidate project for Europe within the frame of the 2015-2025 Cosmic Vision program. Such a mission would represent the natural follow-on to XMM Newton, providing a large aperture X-ray telescope combined with high spectral and time resolution instruments, capable of investigating matter under extreme conditions and the evolution of the early universe. The paper summarises the results of the most recent ESA internal study activities, leading to an updated mission configuration, with a mirror and a detector spacecraft flying in formation around L2 and a consolidated scientific payload design. The paper also describes the ongoing technology development activities for the payload and for the spacecraft that will play a crucial role in case ESA would decide to develop such a mission.

Large format array controller (aLFA-C): tests and characterisation at ESA

NASA Astrophysics Data System (ADS)

Lemmel, Frédéric; ter Haar, Jörg; van der Biezen, John; Duvet, Ludovic; Nelms, Nick; Blommaert, Sander; Butler, Bart; van der Luijt, Cornelis; Heijnen, Jerko; Smit, Hans; Visser, Ivo

2016-08-01

For future near infrared astronomy missions, ESA is developing a complete detection and conversion chain (photon to SpaceWire chain system): Large Format Array (aLFA-N) based on MCT type detectors. aLFA-C (Astronomy Large Format Array Controller): a versatile cryogenic detector controller. An aLFA-C prototype was developed by Caeleste (Belgium) under ESA contract (400106260400). To validate independently the performances of the aLFA-C prototype and consolidate the definition of the follow-on activity, a dedicated test bench has been designed and developed in ESTEC/ESA within the Payload Technology Validation group. This paper presents the test setup and the performance validation of the first prototype of this controller at room and cryogenic temperature. Test setup and software needed to test the HAWAII-2RG and aLFA-N detectors with the aLFA-C prototype at cryogenic temperature will be also presented.

Understanding the features in the ultrafast transient absorption spectra of CdSe quantum dots

NASA Astrophysics Data System (ADS)

Zhang, Cheng; Do, Thanh Nhut; Ong, Xuanwei; Chan, Yinthai; Tan, Howe-Siang

2016-12-01

We describe a model to explain the features of the ultrafast transient absorption (TA) spectra of CdSe core type quantum dots (QDs). The measured TA spectrum consists of contributions by the ground state bleach (GSB), stimulated emission (SE) and excited state absorption (ESA) processes associated with the three lowest energy transition of the QDs. We model the shapes of the GSB, SE and ESA spectral components after fits to the linear absorption. The spectral positions of the ESA components take into account the biexcitonic binding energy. In order to obtain the correct weightage of the GSB, SE and ESA components to the TA spectrum, we enumerate the set of coherence transfer pathways associated with these processes. From our fits of the experimental TA spectra of 65 Å diameter QDs, biexcitonic binding energies for the three lowest energy transitions are obtained.

Space transportation systems within ESA programmes: Current status and perspectives

NASA Astrophysics Data System (ADS)

Delahais, Maurice

1993-03-01

An overview of the space transportation aspects of the ESA (European Space Agency) programs as they result from history, present status, and decisions taken at the ministerial level conference in Granada, Spain is presented. The new factors taken into consideration for the long term plan proposed in Munich, Germany, the three strategic options for the reorientation of the ESA long term plan, and the essential elements of space transportation in the Granada long term plan in three areas of space activities, scientific, and commercial launches with expendable launch vehicles, manned flight and in-orbit infrastructure, and future transportation systems are outlined. The new ESA long term plan, in the field of space transportation systems, constitutes a reorientation of the initial program contemplated in previous councils at ministerial level. It aims at balancing the new economic situation with the new avenues of cooperation, and the outcome will be a new implementation of the space transportation systems policy.

The Ocean Surface Topography Constellation: The Next 15 Years in Satellite Altimetry

DTIC Science & Technology

2012-02-22

global coverage in 2007 - to estimate changes in volume due to the warming of the oceans. 5.2 Ocean State Estimation Regarding ocean climate analyses...Ocean Observations and Information for Society" Conference (Vol. 2), Venice, Italy, 21-25 September 2009, Hall, J., Harrison D.E. and Stammer , D., Eds...Venice, Italy, 21-25 September 2009, Hall, J„ Harrison D.E. and Stammer , D., Eds., ESA Publication WPP-306, 2010. 8. Balmaseda, M., Alves, O

Laboratory Spectroscopy of Ices of Astrophysical Interest

NASA Technical Reports Server (NTRS)

Hudson, Reggie; Moore, M. H.

2011-01-01

Ongoing and future NASA and ESA astronomy missions need detailed information on the spectra of a variety of molecular ices to help establish the identity and abundances of molecules observed in astronomical data. Examples of condensed-phase molecules already detected on cold surfaces include H2O, CO, CO2, N2, NH3, CH4, SO2, O2, and O3. In addition, strong evidence exists for the solid-phase nitriles HCN, HC3N, and C2N2 in Titan's atmosphere. The wavelength region over which these identifications have been made is roughly 0.5 to 100 micron. Searches for additional features of complex carbon-containing species are in progress. Existing and future observations often impose special requirements on the information that comes from the laboratory. For example, the measurement of spectra, determination of integrated band strengths, and extraction of complex refractive indices of ices (and icy mixtures) in both amorphous and crystalline phases at relevant temperatures are all important tasks. In addition, the determination of the index of refraction of amorphous and crystalline ices in the visible region is essential for the extraction of infrared optical constants. Similarly, the measurement of spectra of ions and molecules embedded in relevant ices is important. This laboratory review will examine some of the existing experimental work and capabilities in these areas along with what more may be needed to meet current and future NASA and ESA planetary needs.

Overview of GPM Missions's Ground Validation Program

NASA Technical Reports Server (NTRS)

Smith, Eric A.; Mugnai, Alberto; Nakamura, Kenji

2004-01-01

An important element of the internationally structured Global Precipitation Measurement (GPM) mission will be its ground validation research program. Within the last year, the initial architecture of this program has taken shape. This talk will describe that architecture, both in terms of the international program and in terms of the separate regional programs of the principle participating space agencies, i.e., ESA, JAXA, and NASA. There are three overriding goals being addressed in the planning of this program; (1) establishing various new, challenging and important scientific research goals vis-a-vis current ground validation programs supporting satellite retrieval of precipitation; (2) designing the program as an international partnership which operates, out of necessity, heterogeneous sites in terms of their respective observational foci and science thrusts, but anneals itself in terms of achieving a few overarching scientific objectives; and (3) developing a well-designed protocol that allows specific sites or site networks, at their choosing, to operate in a 'supersite' mode - defined as the capability to routinely transmit GV information at low latency to GPM's Precipitation Processing System (PPS). (The PPS is being designed as GPM's data information system, a distributed data system with main centers at the Goddard Space Flight Center (GSFC) within NASA, the Earth Observation Research Center (EORC) within JAXA, and a TBD facility to be identified by the ESA s ESTEC facility in Noordwijk.)

Supplemental information on National Woodland Owner Survey 2011-2013 two-page summary reports

Treesearch

Brett J. Butler; Sarah M. Butler

2016-01-01

This document provides explanations of the data sources, graphics, and summaries presented in the 41 national, regional, and state National Woodland Owner Survey 2011-2013 two-page research note summary reports (Research Note NRS-206 through Research Note NRS-246). All of these research notes can be accessed at ...

Scope Notes for LISA Subject Headings.

ERIC Educational Resources Information Center

Browne, Glenda

1992-01-01

Reports on a study that examined scope notes added to subject headings in the Library and Information Science Abstracts (LISA) Online User Manual. Types of messages conveyed by scope notes and word patterns within the notes are identified, and comparisons between the 1982 and 1987 editions of the manual are made. (16 references) (MES)

Survey of Sensitive Information Written in Patient Notes by Psychiatry Trainees

ERIC Educational Resources Information Center

Kung, Simon; Lapid, Maria I.; Swintak, Cosima C.; Agarwal, Zubin; Ryan, Susan M.; Lineberry, Timothy W.

2013-01-01

Objective: Allowing psychiatric patients access to their electronic medical record (EMR) may cause difficulty related to the sensitivity of the note content. The authors investigated whether notes written by psychiatry trainees were ready for release to patients. Methods: Authors conducted a review of 128 PGY-3 to PGY-5 outpatient notes not…

Interactive Webmap-Based Science Planning for BepiColombo

NASA Astrophysics Data System (ADS)

McAuliffe, J.; Martinez, S.; Ortiz de Landaluce, I.; de la Fuente, S.

2015-10-01

For BepiColombo, ESA's Mission to Mercury, we will build a web-based, map-based interface to the Science Planning System. This interface will allow the mission's science teams to visually define targets for observations and interactively specify what operations will make up the given observation. This will be a radical departure from previous ESA mission planning methods. Such an interface will rely heavily on GIS technologies. This interface will provide footprint coverage of all existing archived data for Mercury, including a set of built-in basemaps. This will allow the science teams to analyse their planned observations and operational constraints with relevant contextual information from their own instrument, other BepiColombo instruments or from previous missions. The interface will allow users to import and export data in commonly used GIS formats, such that it can be visualised together with the latest planning information (e.g. import custom basemaps) or analysed in other GIS software. The interface will work with an object-oriented concept of an observation that will be a key characteristic of the overall BepiColombo scienceplanning concept. Observation templates or classes will be tracked right through the planning-executionprocessing- archiving cycle to the final archived science products. By using an interface that synthesises all relevant available information, the science teams will have a better understanding of the operational environment; it will enhance their ability to plan efficiently minimising or removing manual planning. Interactive 3D visualisation of the planned, scheduled and executed observations, simulation of the viewing conditions and interactive modification of the observation parameters are also being considered.

Detecting Protected Health Information in Heterogeneous Clinical Notes.

PubMed

Henriksson, Aron; Kvist, Maria; Dalianis, Hercules

2017-01-01

To enable secondary use of healthcare data in a privacy-preserving manner, there is a need for methods capable of automatically identifying protected health information (PHI) in clinical text. To that end, learning predictive models from labeled examples has emerged as a promising alternative to rule-based systems. However, little is known about differences with respect to PHI prevalence in different types of clinical notes and how potential domain differences may affect the performance of predictive models trained on one particular type of note and applied to another. In this study, we analyze the performance of a predictive model trained on an existing PHI corpus of Swedish clinical notes and applied to a variety of clinical notes: written (i) in different clinical specialties, (ii) under different headings, and (iii) by persons in different professions. The results indicate that domain adaption is needed for effective detection of PHI in heterogeneous clinical notes.

Dose conversion ratio in hemodialysis patients switched from darbepoetin alfa to PEG-epoetin beta: AFFIRM study.

PubMed

Choi, Peter; Farouk, Mourad; Manamley, Nick; Addison, Janet

2013-11-01

There is limited information published on switching erythropoiesis-stimulating agent (ESA) treatment for anemia associated with chronic kidney disease (CKD) from darbepoetin alfa (DA) to methoxy polyethylene glycol-epoetin beta (PEG-Epo) outside the protocol of interventional clinical studies. AFFIRM (Aranesp Efficiency Relative to Mircera) was a retrospective, multi-site, observational study designed to estimate the population mean maintenance dose conversion ratio [DCR; dose ratio achieving comparable hemoglobin level (Hb) between two evaluation periods] in European hemodialysis patients whose treatment was switched from DA to PEG-Epo. Eligible patients had received hemodialysis for ≥ 12 months and DA for ≥ 7 months. Data were collected from 7 months before until 7 months after switching treatment. DCR was calculated for patients with Hb and ESA data available in both evaluation periods (EP; Months 1 and 2 were defined as the pre-switch EP, and Months 6 and 7 as the post-switch EP). Red blood cell transfusions pre- and post-switch were quantified. Of 302 patients enrolled, 206 had data available for DCR analysis. The geometric mean DCR was 1.17 (95% CI 1.05, 1.29). Regression analysis indicated a non-linear relationship between pre- and post-switch ESA doses; DCR decreased with increasing pre-switch DA dose. The geometric mean weekly ESA doses were 24.1 μg DA in the pre-switch EP and 28.6 μg PEG-Epo in the post-switch EP. Mean Hb was 11.5 g/dL in the pre-switch EP and 11.4 g/dL in the post-switch EP. There were 16 transfusions and 34 units transfused in the pre-switch period, versus 48 transfusions and 95 units transfused post-switch. Excluding patients receiving a transfusion within 90 days of or during either EP, the DCR was 1.21 (95% CI 1.09, 1.35). In these hemodialysis patients switched from DA to PEG-Epo the DCR was 1.17 and 1.21 after accounting for the effect of transfusions. The number of transfusions and units transfused increased approximately threefold from the pre-switch to the post-switch period.

Earth observing system - Concepts and implementation strategy

NASA Technical Reports Server (NTRS)

Hartle, R. E.

1986-01-01

The concepts of an Earth Observing System (EOS), an information system being developed by the EOS Science and Mission Requirements Working Group for international use and planned to begin in the 1990s, are discussed. The EOS is designed to study the factors that control the earth's hydrologic cycle, biochemical cycles, and climatologic processes by combining the measurements from remote sensing instruments, in situ measurement devices, and a data and information system. Three EOS platforms are planned to be launched into low, polar, sun-synchronous orbits during the Space Station's Initial Operating Configuration, one to be provided by ESA and two by the United States.

Space information systems in the Space Station era; Proceedings of the AIAA/NASA International Symposium on Space Information Systems, Washington, DC and Greenbelt, MD, June 22, 23, 1987

NASA Technical Reports Server (NTRS)

Gerard, Mireille (Editor); Edwards, Pamela W. (Editor)

1988-01-01

Technological and planning issues for data management, processing, and communication on Space Station Freedom are discussed in reviews and reports by U.S., European, and Japanese experts. The space-information-system strategies of NASA, ESA, and NASDA are discussed; customer needs are analyzed; and particular attention is given to communication and data systems, standards and protocols, integrated system architectures, software and automation, and plans and approaches being developed on the basis of experience from past programs. Also included are the reports from workshop sessions on design to meet customer needs, the accommodation of growth and new technologies, and system interoperability.

Hemodynamic monitoring and management in patients undergoing high risk surgery: a survey among North American and European anesthesiologists.

PubMed

Cannesson, Maxime; Pestel, Gunther; Ricks, Cameron; Hoeft, Andreas; Perel, Azriel

2011-08-15

Several studies have demonstrated that perioperative hemodynamic optimization has the ability to improve postoperative outcome in high-risk surgical patients. All of these studies aimed at optimizing cardiac output and/or oxygen delivery in the perioperative period. We conducted a survey with the American Society of Anesthesiologists (ASA) and the European Society of Anaesthesiology (ESA) to assess current hemodynamic management practices in patients undergoing high-risk surgery in Europe and in the United States. A survey including 33 specific questions was emailed to 2,500 randomly selected active members of the ASA and to active ESA members. Overall, 368 questionnaires were completed, 57.1% from ASA and 42.9% from ESA members. Cardiac output is monitored by only 34% of ASA and ESA respondents (P = 0.49) while central venous pressure is monitored by 73% of ASA respondents and 84% of ESA respondents (P < 0.01). Specifically, the pulmonary artery catheter is being used much more frequently in the US than in Europe in the setup of high-risk surgery (85.1% vs. 55.3% respectively, P < 0.001). Clinical experience, blood pressure, central venous pressure, and urine output are the most widely indicators of volume expansion. Finally, 86.5% of ASA respondents and 98.1% of ESA respondents believe that their current hemodynamic management could be improved. In conclusion, these results point to a considerable gap between the accumulating evidence about the benefits of perioperative hemodynamic optimization and the available technologies that may facilitate its clinical implementation, and clinical practices in both Europe and the United States.

The scientific programme between ESRO and ESA: Choosing new projects (1973-1977)

NASA Astrophysics Data System (ADS)

Russo, Arturo

1995-02-01

The ESA History Study Reports are preliminary reports of studies carried out within the framework of an ESA (European Space Agency) contract. They will form the basis of a comprehensive study of European Space activities covering the period 1959-1987. The transformation of ESRO (European Space Research Organization) into ESA found the Organization's bodies involved in a new round of the decision-making process to select future scientific satellite projects. In this report, the three main phases of the decision-making process are discussed. The first, from June 1973 to April 1974, the European scientific community and their representatives in ESA's advisory committee structure were invited to agree on a set of space missions for which a definition study was recommended. At the end of this phase, thirteen missions were selected for such a definition study by ESRO's Scientific Program Board (SPB). The second phase covers the period from that decision up to March 1975, when a much more important decision was required, namely to select a restricted number of missions for which a feasibility study was to be performed. The aims of such feasibility studies were to establish the technical and financial feasibility of each project, to propose a well-defined project concept, to identify the research and technology effort required to support it, and to state a preliminary cost estimate to completion. The third phase covers the first two years of the new Agency's life, and concludes with the selection of the projects to be adopted in ESA's scientific program.

Quorum-sensing regulation governs bacterial adhesion, biofilm development, and host colonization in Pantoea stewartii subspecies stewartii.

PubMed

Koutsoudis, Maria D; Tsaltas, Dimitrios; Minogue, Timothy D; von Bodman, Susanne B

2006-04-11

The phytopathogenic bacterium Pantoea stewartii subsp. stewartii synthesizes stewartan exo/capsular polysaccharide (EPS) in a cell density-dependent manner governed by the EsaI/EsaR quorum-sensing (QS) system. This study analyzes biofilm development and host colonization of the WT and QS regulatory mutant strains of P. stewartii. First, we show that the cell density-dependent synthesis of stewartan EPS, governed by the EsaI/EsaR QS system, is required for proper bacterial adhesion and development of spatially defined, 3D biofilms. Second, a nonvirulent mutant lacking the esaI gene adheres strongly to surfaces and develops densely packed, less structurally defined biofilms in vitro. This strain appears to be arrested in a low cell density developmental mode. Exposure of this strain to exogenous N-acyl-homoserine lactone counteracts this adhesion phenotype. Third, QS mutants lacking the EsaR repressor attach poorly to surfaces and form amorphous biofilms heavily enmeshed in excess EPS. Fourth, the WT strain disseminates efficiently within the xylem, primarily in a basipetal direction. In contrast, the two QS mutant strains remain largely localized at the site of infection. Fifth, and most significantly, epifluorescence microscopic imaging of infected leaf tissue and excised xylem vessels reveals that the bacteria colonize the xylem with unexpected specificity, particularly toward the annular rings and spiral secondary wall thickenings of protoxylem, as opposed to indiscriminate growth to fill the xylem lumen. These observations are significant to bacterial plant pathogenesis in general and may reveal targets for disease control.

Quorum-sensing regulation governs bacterial adhesion, biofilm development, and host colonization in Pantoea stewartii subspecies stewartii

PubMed Central

Koutsoudis, Maria D.; Tsaltas, Dimitrios; Minogue, Timothy D.; von Bodman, Susanne B.

2006-01-01

The phytopathogenic bacterium Pantoea stewartii subsp. stewartii synthesizes stewartan exo/capsular polysaccharide (EPS) in a cell density-dependent manner governed by the EsaI/EsaR quorum-sensing (QS) system. This study analyzes biofilm development and host colonization of the WT and QS regulatory mutant strains of P. stewartii. First, we show that the cell density-dependent synthesis of stewartan EPS, governed by the EsaI/EsaR QS system, is required for proper bacterial adhesion and development of spatially defined, 3D biofilms. Second, a nonvirulent mutant lacking the esaI gene adheres strongly to surfaces and develops densely packed, less structurally defined biofilms in vitro. This strain appears to be arrested in a low cell density developmental mode. Exposure of this strain to exogenous N-acyl-homoserine lactone counteracts this adhesion phenotype. Third, QS mutants lacking the EsaR repressor attach poorly to surfaces and form amorphous biofilms heavily enmeshed in excess EPS. Fourth, the WT strain disseminates efficiently within the xylem, primarily in a basipetal direction. In contrast, the two QS mutant strains remain largely localized at the site of infection. Fifth, and most significantly, epifluorescence microscopic imaging of infected leaf tissue and excised xylem vessels reveals that the bacteria colonize the xylem with unexpected specificity, particularly toward the annular rings and spiral secondary wall thickenings of protoxylem, as opposed to indiscriminate growth to fill the xylem lumen. These observations are significant to bacterial plant pathogenesis in general and may reveal targets for disease control. PMID:16585516

ISO completes its observations of the Universe by infrared light

NASA Astrophysics Data System (ADS)

1998-04-01

At 07:00 on 8 April 1998, engineers at ESA's ground station at Villafranca near Madrid reported that ISO's telescope was beginning to warm up, above its nominal operating temperature close to absolute zero. This was the sign that ISO had exhausted the superfluid helium used to achieve the very low temperatures necessary for infrared astronomy. Observations ceased at 23h07 when the temperature of the instruments had risen above -269°C. At that time, ISO was observing the galaxy NGC 1808 with the camera (ISOCAM) for Prof. J. Hough (UK). The astronomers then handed ISO over to the engineering team for check-outs and decommissioning. The spacecraft will be switched off in about 28 days' time. Infrared rays come from cool places in the sky, and ISO would have been dazzled by its own heat unless its optical system were extremely cold. At its launch in November 1995, ISO carried a supply of 2000 litres of superfluid helium, which boils at -271 degrees C. Slow venting of the helium into space maintained the low temperature of the optical system. How did ISO achieve its extended life? Three months came from a prudent safety margin in the engineering calculations of the rate of loss of helium. Two months were the result of favourable circumstances in the launch campaign at Kourou in French Guiana. During a technical check of the Ariane 44P launcher, ISO's engineers seized the chance to recharge the helium, and the quick launch that followed meant that the outer parts of the cryogenic system of the spacecraft had little time to warm up in Kourou's tropical climate. Finally, the daily loss of helium turned out to be 17 less than expected, at the lower end of a range of possibilities considered by the engineers. That gave ISO an estimated five months of additional life. The date for the helium to run out remained somewhat uncertain, and astronomers and engineers have been alert to the possibility of its exhaustion for the past few weeks. The huge bonus to astronomers, from ISO's long operating life, is only one of their reasons to be grateful for the highly successful engineering and operations of ISO. The pointing accuracy of ISO's telescope was ten times better than required by the specification, and its jitter was one-fifth of what would have been considered tolerable. Smooth, well-planned operations were extended on a daily basis by a US ground station supporting ESA's Villafranca station. ISO was observing selected targets in the sky for 90-95 of the time available. Even in between the planned observations a "serendipity" programme with the ISOPHOT instrument charted cool objects as ISO slewed from one target to the next. Although ISO's observations are now completed, astronomers will be analysing them for years to come, assisted by a team of mission experts who will continue their work at Villafranca and other centres worldwide until 2001. Commenting on the completion of ISO's observational phase, ESA's director of science, Roger Bonnet, says: "We always knew that ISO's helium would run out one day, and we can be grateful that it has lasted for so long. This is a time for celebration, not sorrow, and I congratulate the VILSPA, ESTEC and ESOC staff who have operated so efficiently the spacecraft as well as European industry which developed such an excellent mission and our scientists who built such an outstanding payload . I wish European astronomers as well as their colleagues from the USA and Japan to now fully exploit the image data acquired by ISO". For further information, please contact : ESA Public Relations Division Martin Kessler Tel: +33(0)1.53.69.71.55 ISO Project Scientist Fax: +33(0)1.53.69.76.90 Tel :+34 (9)1.813.1253 e-mail: mkessler @iso.vilspa.esa.es For background information, consult ISO's wwwpages at : isowww.estec.esa.nl

Semantic characteristics of NLP-extracted concepts in clinical notes vs. biomedical literature.

PubMed

Wu, Stephen; Liu, Hongfang

2011-01-01

Natural language processing (NLP) has become crucial in unlocking information stored in free text, from both clinical notes and biomedical literature. Clinical notes convey clinical information related to individual patient health care, while biomedical literature communicates scientific findings. This work focuses on semantic characterization of texts at an enterprise scale, comparing and contrasting the two domains and their NLP approaches. We analyzed the empirical distributional characteristics of NLP-discovered named entities in Mayo Clinic clinical notes from 2001-2010, and in the 2011 MetaMapped Medline Baseline. We give qualitative and quantitative measures of domain similarity and point to the feasibility of transferring resources and techniques. An important by-product for this study is the development of a weighted ontology for each domain, which gives distributional semantic information that may be used to improve NLP applications.

Mars Sample Return Orbiter Architecture Options — Results of the ESA Mars Sample Return Architecture Assessment Study

NASA Astrophysics Data System (ADS)

Derz, U.; Joffre, E.; Perkinson, M.-C.; Huesing, J.; Beyer, F.; Sanchez Perez, J. M.

2018-04-01

This paper presents the identified most promising chemical and electric propulsion architecture options of the Mars Sample Return (MSR) orbiter identified during the recent ESA MSR Architecture Assessment Study.

Development of the flight models for the Sentinel-4/UVN NIR-grating unit

NASA Astrophysics Data System (ADS)

Zeitner, U. D.; Kamm, A.; Benkenstein, T.; Flügel-Paul, T.; Leibeling, G.

2017-09-01

In the frame of ESA`s earth-observation program "Copernicus", the Fraunhofer IOF develops for the Sentinel-4/UVN spectrometer, the optical gratings for the near-infrared spectral channel together with its isostatic mounts.

Kuipers works with Stowage in ATV3

NASA Image and Video Library

2012-05-15

ISS031-E-084591 (15 May 2012) --- European Space Agency astronaut Andre Kuipers, Expedition 31 flight engineer, is pictured during cargo operations in ESA?s "Edoardo Amaldi" Automated Transfer Vehicle-3 (ATV-3) currently docked with the International Space Station.

EAC trains its first international astronaut class.

PubMed

Bolender, Hans; Bessone, Loredana; Schoen, Andreas; Stevenin, Herve

2002-11-01

After several years of planning and preparation, ESA's ISS training programme has become operational. Between 26 August and 6 September, the European Astronaut Centre (EAC) near Cologne gave the first ESA advanced training course for an international ISS astronaut class. The ten astronauts who took part--two from NASA, four from Japan and four from ESA--had begun their advanced training programme back in 2001 with sessions at the Johnson Space Center (JSC) in Houston and at the Japanese Training Centre in Tsukuba. During their stay in Cologne, the ten astronauts participated in a total of 33 classroom lessons and hands-on training sessions, which gave them a detailed overview of the systems and subsystems of the Columbus module, the Automated Transfer Vehicle (ATV), and the related crew operations tasks. They were also introduced to the four ESA experiment facilities to be operated inside the Columbus module. After their first week of training at EAC, the astronauts were given the opportunity to see the flight model of the Columbus module being integrated at the site of ESA's ISS prime contractor, Astrium in Bremen. The second week of training at EAC included hands-on instruction on the Columbus Data Management System (DMS) using the recently installed Columbus Crew Training Facility. In preparation for the first advanced crew training session at EAC, two Training Readiness Reviews (TRR) were conducted there in June and August. These reviews were supported by training experts and astronauts from NASA, NASDA and CSA (Canada), who were introduced to ESA's advanced training concept and the development process, and then analysed and evaluated the training flow, content and instructional soundness of lessons and courses, as well as the fidelity of the training facilities and the skills of the ESA training instructors. The International Training Control Board (ITCB), made up of representatives from all of the ISS International Partners and mandated to control and coordinate all multilateral training for ISS crew and ground-support personnel, testified to ESA's readiness to provide Advanced Training by declaring the EAC TRR successful. The completion of this first training course was therefore a good opportunity for the Astronaut Training Division to assess the status of its training programme. The comments and recommendations of the training experts and the astronauts who took part have been carefully evaluated and the results are being fed back into the ongoing training development process.

Association between serum alkaline phosphatase and primary resistance to erythropoiesis stimulating agents in chronic kidney disease: a secondary analysis of the HERO trial.

PubMed

Badve, Sunil V; Zhang, Lei; Coombes, Jeff S; Pascoe, Elaine M; Cass, Alan; Clarke, Philip; Ferrari, Paolo; McDonald, Stephen P; Morrish, Alicia T; Pedagogos, Eugenie; Perkovic, Vlado; Reidlinger, Donna; Scaria, Anish; Walker, Rowan; Vergara, Liza A; Hawley, Carmel M; Johnson, David W

2015-01-01

Erythropoiesis stimulating agent (ESA)-resistant anemia is common in chronic kidney disease (CKD). To evaluate the determinants of severity of ESA resistance in patients with CKD and primary ESA-resistance. Secondary analysis of a randomized controlled trial (the Handling Erythropoietin Resistance with Oxpentifylline, HERO). 53 adult patients with CKD stage 4 or 5 and primary ESA-resistant anemia (hemoglobin ≤120 g/L, ESA resistance index [ERI] ≥1.0 IU/kg/week/gHb for erythropoietin or ≥0.005 μg/kg/week/gHb for darbepoeitin, no cause for ESA-resistance identified). Iron studies, parathyroid hormone, albumin, liver enzymes, phosphate or markers of oxidative stress and inflammation. Participants were divided into tertiles of ERI. Multinomial logistic regression was used to analyse the determinants of ERI tertiles. All patients, except one, were receiving dialysis for end-stage kidney disease. The mean ± SD ERI values in the low (n = 18), medium (n = 18) and high (n = 17) ERI tertiles were 1.4 ± 0.3, 2.3 ± 0.2 and 3.5 ± 0.8 IU/kg/week/gHb, respectively (P < 0.001). There were no significant differences observed in age, gender, ethnicity, cause of kidney disease, diabetes, iron studies, parathyroid hormone, albumin, liver enzymes, phosphate or markers of oxidative stress and inflammation between the ERI tertiles. The median [inter-quartile range] serum alkaline phosphatase concentrations in the low, medium and high ERI tertiles were 89 [64,121], 99 [76,134 and 148 [87,175] U/L, respectively (P = 0.054). There was a weak but statistically significant association between ERI and serum alkaline phosphatase (R(2) = 0.06, P = 0.03). Using multinomial logistic regression, the risk of being in the high ERI tertile relative to the low ERI tertile increased with increasing serum alkaline phosphatase levels (P = 0.02). No other variables were significantly associated with ERI. Small sample size; bone-specific alkaline phosphatase, other markers of bone turnover and bone biopsies not evaluated. Serum alkaline phosphatase was associated with severity of ESA resistance in ESA-resistant patients with CKD. Large prospective studies are required to confirm this association. ( Australian New Zealand Clinical Trials Registry 12608000199314).

NASA and ESA Collaboration on Hexavalent Chrome Alternatives - Pretreatments with Primers Screening Final Test Report

NASA Technical Reports Server (NTRS)

Rothgeb, Matthew J.; Kessel, Kurt R.

2015-01-01

Hexavalent chromium (hex chrome or Cr(VI)) is a widely used element within applied coating systems because of its self-healing and corrosion-resistant properties. The replacement of hex chrome in the processing of aluminum for aviation and aerospace applications remains a goal of great significance. Aluminum is the major manufacturing material of structures and components in the space flight arena. The National Aeronautics and Space Administration (NASA) and the European Space Agency (ESA) are engaged in a collaborative effort to test and evaluate alternatives to hexavalent chromium containing corrosion coating systems. NASA and ESA share common risks related to material obsolescence associated with hexavalent chromium used in corrosion-resistant coatings. In the United States, Occupational Safety and Health Administration (OSHA) studies have concluded that hexavalent chromium is carcinogenic and poses significant risk to human health. On May 5, 2011, amendments to the Defense Federal Acquisition Regulation Supplement (DFARS) were issued in the Federal Register. Subpart 223.73 prohibits contracts from requiring hexavalent chromium in deliverables unless certain exceptions apply. Subpart 252.223-7008 provides the contract clause prohibiting contractors and subcontractors from using or delivering hexavalent chromium in a concentration greater than 0.1 percent by weight for all new contracts associated with supplies, maintenance and repair services, and construction materials. ESA faces its own increasingly stringent regulations within European directives such as Registration, Evaluation, Authorization and Restriction of Chemical (REACH) substances and the Restriction of Hazardous Substances Directive (RoHS) which have set a mid-2017 sunset date for hexavalent chromium. NASA and ESA continue to search for an alternative to hexavalent chromium in coatings applications that meet their performance requirements in corrosion protection, cost, operability, and health and safety, while typically specifying that performance must be equal to or greater than existing systems. The overall objective of the collaborative effort between NASA TEERM and ESA is to test and evaluate coating systems (pretreatments, pretreatments with primer, and pretreatments with primer and topcoat) as replacements for hexavalent chrome coatings in aerospace applications. This objective will be accomplished by testing promising coatings identified from previous NASA, ESA, Department of Defense (DOD), and other project experience. Additionally, several new materials will be analyzed according to ESA-identified specifications.

Ground-based photometric support for the CoRoT mission by the CoRoT-Hungarian Asteroseismology Group

NASA Astrophysics Data System (ADS)

Bognár, Zs.; Paparó, M.

2012-12-01

The CoRoT-Hungarian Asteroseismology Group was established in 2005 and joined the preparatory work of the CoRoT Mission via an ESA PECS project. After the successful launch of the telescope, we have continued our work of ground-based multi-colour photometric observations and contributed to the analyses of CoRoT data. Our observations were focused on δ Scuti, γ Doradus, and RR Lyrae stars. The follow-up of some selected targets' pulsations in different wavelengths has provided valuable information for mode identification. We provided additional support by the confirmation of relatively faint variables' spectral types. We proved that our ground-based observations can help in the interpretation of a target with a contaminated CoRoT light curve. In this paper, we summarize our most important results of the photometric support for the CoRoT Mission. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain.

Advances in Assimilation of Satellite-Based Passive Microwave Observations for Soil-Moisture Estimation

NASA Technical Reports Server (NTRS)

De Lannoy, Gabrielle J. M.; Pauwels, Valentijn; Reichle, Rolf H.; Draper, Clara; Koster, Randy; Liu, Qing

2012-01-01

Satellite-based microwave measurements have long shown potential to provide global information about soil moisture. The European Space Agency (ESA) Soil Moisture and Ocean Salinity (SMOS, [1]) mission as well as the future National Aeronautics and Space Administration (NASA) Soil Moisture Active and Passive (SMAP, [2]) mission measure passive microwave emission at L-band frequencies, at a relatively coarse (40 km) spatial resolution. In addition, SMAP will measure active microwave signals at a higher spatial resolution (3 km). These new L-band missions have a greater sensing depth (of -5cm) compared with past and present C- and X-band microwave sensors. ESA currently also disseminates retrievals of SMOS surface soil moisture that are derived from SMOS brightness temperature observations and ancillary data. In this research, we address two major challenges with the assimilation of recent/future satellite-based microwave measurements: (i) assimilation of soil moisture retrievals versus brightness temperatures for surface and root-zone soil moisture estimation and (ii) scale-mismatches between satellite observations, models and in situ validation data.

77 FR 76740 - Endangered and Threatened Species; Threatened Status for the Beringia and Okhotsk Distinct...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-28

...We, NMFS, issue a final determination to list the Beringia and Okhotsk distinct populations segments (DPSs) of the Erignathus barbatus nauticus subspecies of the bearded seal (Erignathus barbatus) as threatened under the Endangered Species Act (ESA). We will propose to designate critical habitat for the Beringia DPS in a future rulemaking. To assist us with this effort, we solicit information that may be relevant to the designation of critical habitat for the Beringia DPS. In light of public comments and upon further review, we are withdrawing the proposed ESA section 4(d) protective regulations for the Beringia and Okhotsk DPSs because we have determined that such regulations are not necessary or advisable for the conservation of the Beringia and Okhotsk DPSs at this time. Given their current population sizes, the long-term nature of the primary threat to these DPSs (habitat alteration stemming from climate change), and the existing protections under the Marine Mammal Protection Act, it is unlikely that the proposed protective regulations would provide appreciable conservation benefits.

76 FR 18145 - Privacy Act of 1974; New System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

... to include final determinations; billing information to include payment delinquencies; case notes... delinquencies; and case notes. Information collected includes the individual's name, address, telephone number... outside USDA, and so have some impact on privacy of individuals, they are either necessary for carrying...

MedEx: a medication information extraction system for clinical narratives

PubMed Central

Stenner, Shane P; Doan, Son; Johnson, Kevin B; Waitman, Lemuel R; Denny, Joshua C

2010-01-01

Medication information is one of the most important types of clinical data in electronic medical records. It is critical for healthcare safety and quality, as well as for clinical research that uses electronic medical record data. However, medication data are often recorded in clinical notes as free-text. As such, they are not accessible to other computerized applications that rely on coded data. We describe a new natural language processing system (MedEx), which extracts medication information from clinical notes. MedEx was initially developed using discharge summaries. An evaluation using a data set of 50 discharge summaries showed it performed well on identifying not only drug names (F-measure 93.2%), but also signature information, such as strength, route, and frequency, with F-measures of 94.5%, 93.9%, and 96.0% respectively. We then applied MedEx unchanged to outpatient clinic visit notes. It performed similarly with F-measures over 90% on a set of 25 clinic visit notes. PMID:20064797

A study of actions in operative notes.

PubMed

Wang, Yan; Pakhomov, Serguei; Burkart, Nora E; Ryan, James O; Melton, Genevieve B

2012-01-01

Operative notes contain rich information about techniques, instruments, and materials used in procedures. To assist development of effective information extraction (IE) techniques for operative notes, we investigated the sublanguage used to describe actions within the operative report 'procedure description' section. Deep parsing results of 362,310 operative notes with an expanded Stanford parser using the SPECIALIST Lexicon resulted in 200 verbs (92% coverage) including 147 action verbs. Nominal action predicates for each action verb were gathered from WordNet, SPECIALIST Lexicon, New Oxford American Dictionary and Stedman's Medical Dictionary. Coverage gaps were seen in existing lexical, domain, and semantic resources (Unified Medical Language System (UMLS) Metathesaurus, SPECIALIST Lexicon, WordNet and FrameNet). Our findings demonstrate the need to construct surgical domain-specific semantic resources for IE from operative notes.

The Influence of Prior Knowledge on the Retrieval-Directed Function of Note Taking in Prior Knowledge Activation

ERIC Educational Resources Information Center

Wetzels, Sandra A. J.; Kester, Liesbeth; van Merrienboer, Jeroen J. G.; Broers, Nick J.

2011-01-01

Background: Prior knowledge activation facilitates learning. Note taking during prior knowledge activation (i.e., note taking directed at retrieving information from memory) might facilitate the activation process by enabling learners to build an external representation of their prior knowledge. However, taking notes might be less effective in…

Learning from Lectures: The Implications of Note-Taking for Students with Learning Disabilities

ERIC Educational Resources Information Center

Boyle, Joseph R.

2006-01-01

Students with learning disabilities lack effective note-taking skills for a variety of reasons. Despite the important role that notes play in helping students to understand lecture content information and serving as documents for later review, many students with learning disabilities are simply not effective note-takers. Many of these students…

Medical students' note-taking in a medical biochemistry course: an initial exploration.

PubMed

Morrison, Elizabeth H; McLaughlin, Calvin; Rucker, Lloyd

2002-04-01

Beginning medical students spend numerous hours every week attending basic science lectures and taking notes. Medical faculty often wonder whether they should give students pre-printed instructors' notes before lectures. Proponents of this strategy argue that provided notes enhance learning by facilitating the accurate transmission of information, while opponents counter that provided notes inhibit students' cognitive processing or even discourage students from attending lectures. Little if any research has directly addressed medical students' note-taking or the value of providing instructors' notes. The educational literature does suggest that taking lecture notes enhances university students' learning. University students perform best on post-lecture testing if they review a combination of provided notes and their own personal notes, particularly if the provided notes follow a 'skeletal' format that encourages active note-taking.

The results of the thin x-ray mirror module production for the ESA XMM spacecraft

NASA Astrophysics Data System (ADS)

de Chambure, Daniel; Laine, Robert; Grisoni, Gabriele; Kampf, Dirck

2018-04-01

This paper, "The results of the thin x-ray mirror module production for the ESA XMM spacecraft," was presented as part of International Conference on Space Optics—ICSO 1997, held in Toulouse, France.

ESA Astronaut Andreas Mogensen and NASA astronaut Randy Bresnik during NEEMO 19 communications training with instructors

NASA Image and Video Library

2014-08-21

Date: 08-21-14 Location: Bldg 36, 131 Subject: ESA Astronaut Andreas Mogensen and NASA astronaut Randy Bresnik during NEEMO 19 communications training with instructors Marcum Reagan and Barbara Janoiko Photographer: James Blair

Description of European Space Agency (ESA) Concept Development for a Mars Sample Receiving Facility (MSRF)

NASA Astrophysics Data System (ADS)

Vrublevskis, J.; Berthoud, L.; Guest, M.; Smith, C.; Bennett, A.; Gaubert, F.; Schroeven-Deceuninck, H.; Duvet, L.; van Winnendael, M.

2018-04-01

This presentation gives an overview of the several studies conducted for the European Space Agency (ESA) since 2007, which progressively developed layouts for a potential implementation of a Mars Sample Receiving Facility (MSRF).

MSR ESA Earth Return Orbiter Mission Design Trades

NASA Astrophysics Data System (ADS)

Sanchez Perez, J. M.; Varga, G. I.; Huesing, J.; Beyer, F.

2018-04-01

The paper describes the work performed at ESOC in support of the Mars Sample Return ESA Earth Return Orbiter definition studies by exploring the trajectory optimization and mission design trade spaces of Mars return missions using electric and chemical propulsion.

Volkov prepares for the undocking of the ESA Jules Verne ATV during Expedition 17

NASA Image and Video Library

2008-09-05

ISS017-E-015230 (5 Sept. 2008) --- Russian Federal Space Agency cosmonaut Sergei Volkov, Expedition 17 commander, makes preparations in the International Space Station's Zvezda Service Module for the undocking of the European Space Agency's (ESA) "Jules Verne" Automated Transfer Vehicle (ATV). The ATV departed from the aft port of Zvezda at 4:29 p.m. (CDT) on Sept. 5, 2008 and was placed in a parking orbit for three weeks, scheduled to be deorbited on Sept. 29 when lighting conditions are correct for an ESA imagery experiment of reentry.

ESA's CCD test bench for the PLATO mission

NASA Astrophysics Data System (ADS)

Beaufort, Thierry; Duvet, Ludovic; Bloemmaert, Sander; Lemmel, Frederic; Prod'homme, Thibaut; Verhoeve, Peter; Smit, Hans; Butler, Bart; van der Luijt, Cornelis; Heijnen, Jerko; Visser, Ivo

2016-08-01

PLATO { PLAnetary Transits and Oscillations of stars { is the third medium-class mission to be selected in the European Space Agency (ESA) Science and Robotic Exploration Cosmic Vision programme. Due for launch in 2025, the payload makes use of a large format (8 cm x 8 cm) Charge-Coupled Devices (CCDs), the e2v CCD270 operated at 4 MHz and at -70 C. To de-risk the PLATO CCD qualification programme initiated in 2014 and support the mission definition process, ESA's Payload Technology Validation section from the Future Missions Office has developed a dedicated test bench.

The Planetary Science Archive (PSA): Exploration and discovery of scientific datasets from ESA's planetary missions

NASA Astrophysics Data System (ADS)

Vallat, C.; Besse, S.; Barbarisi, I.; Arviset, C.; De Marchi, G.; Barthelemy, M.; Coia, D.; Costa, M.; Docasal, R.; Fraga, D.; Heather, D. J.; Lim, T.; Macfarlane, A.; Martinez, S.; Rios, C.; Vallejo, F.; Said, J.

2017-09-01

The Planetary Science Archive (PSA) is the European Space Agency's (ESA) repository of science data from all planetary science and exploration missions. The PSA provides access to scientific datasets through various interfaces at http://psa.esa.int. All datasets are scientifically peer-reviewed by independent scientists, and are compliant with the Planetary Data System (PDS) standards. The PSA has started to implement a number of significant improvements, mostly driven by the evolution of the PDS standards, and the growing need for better interfaces and advanced applications to support science exploitation.

New generation of telemetry systems using CCSDS packetisation - A prototype implementation

NASA Astrophysics Data System (ADS)

Sotta, J. P.; Held, K.

1988-07-01

The system described herein was developed under ESA contract to support the introduction of new telemetry standards based on the packetized telemetry data concept. These standards were derived from recommendations in the frame of work of CCSDS, an inter-Agency committee that counts among its members most European National Agencies, ESA, NASA as well as Japanese NASDA, Indian ISRO and Brazilian INPE and having as objective to facilitate cross-support for space missions. The development is based on the present generation of ESA on-board equipment (OBDH) subsystem and is fully compatible with OBDH bus interfaces and transfer protocol.

Naturally nonanemic dialysis patients: Who are they?

PubMed

Yilmaz, Murvet; Kircelli, Fatih; Artan, Ayse Serra; Oto, Ozgur; Asci, Gulay; Gunestepe, Kutay; Basci, Ali; Ok, Ercan; Sever, Mehmet Sukru

2016-10-01

Introduction Not only anemia, but also erythropoiesis stimulating agent (ESA)s for treating anemia may adversely affect prognosis of chronic hemodialysis patients. Various features of naturally (with no ESA usage) nonanemic patients may be useful for defining several factors in the pathogenesis of anemia. Methods Data, retrieved from the European Clinical Database (EuCliD)-Turkey on naturally nonanemic prevalent chronic hemodialysis patients (n: 201) were compared with their anemic (those who required ESA treatment) counterparts (n: 3948). Findings Mean hemoglobin values were 13.5 ± 0.8 and 11.5 ± 0.9 g/dL in nonanemic and anemic patients, respectively (P < 0.001). Nonanemia status was associated with younger age, male gender, longer dialysis vintage, nondiabetic status, more frequent hepatitis-C virus seropositivity and more frequent arteriovenous fistula usage. Serum ferritin and CRP levels and urea reduction ratio were higher in ESA-requiring patients. One (99%) and two (95.3%) years survival rates of the "naturally nonanemic" patients were superior as compared to anemics (91.0% and 82.6%, respectively), (P < 0.001). Discussion "Naturally nonanemic" status is associated with better survival in prevalent chronic hemodialysis patients; underlying mechanisms in this favorable outcome should be investigated by randomized controlled trials including large number of patients. © 2016 International Society for Hemodialysis.

The technology management process at the European space agency

NASA Astrophysics Data System (ADS)

Guglielmi, M.; Williams, E.; Groepper, P.; Lascar, S.

2010-03-01

Technology is developed at the European Space Agency (ESA) under several programmes: corporate and domain specific, mandatory and optional, with different time horizons and covering different levels of the TRL scale. To improve the transparency and efficiency of the complete process, it was felt necessary to establish an agreed end to end process for the management of all technology R&D activity that could: Include all ESA programmes and consider the requirements of European users Lead to coordinated multi-year work plan and yearly procurement plans Prepare and enable future European space programmes Be harmonized with national initiatives in Europe Thereby establishing the basis for a product policy to reduce risks to technology users, reduce costs and delays, and enhance industrial competitiveness and non-dependence. In response to the above needs, ESA has developed a technology management process called the ESA End-to-End process (E2E), from establishment of the strategy to the monitoring and evaluation of R&D results. In this paper, the complete process will be described in detail including a discussion on its strengths and limitations, and its links to the wider European Harmonization process. The paper will be concluded with the introduction of the ESA Technology Tree: a basic tool to structure and facilitate communication about technology issues.

Simultaneous quantification of acetanilide herbicides and their oxanilic and sulfonic acid metabolites in natural waters.

PubMed

Heberle, S A; Aga, D S; Hany, R; Müller, S R

2000-02-15

This paper describes a procedure for simultaneous enrichment, separation, and quantification of acetanilide herbicides and their major ionic oxanilic acid (OXA) and ethanesulfonic acid (ESA) metabolites in groundwater and surface water using Carbopack B as a solid-phase extraction (SPE) material. The analytes adsorbed on Carbopack B were eluted selectively from the solid phase in three fractions containing the parent compounds (PCs), their OXA metabolites, and their ESA metabolites, respectively. The complete separation of the three compound classes allowed the analysis of the neutral PCs (acetochlor, alachlor, and metolachlor) and their methylated OXA metabolites by gas chromatography/mass spectrometry. The ESA compounds were analyzed by high-performance liquid chromatography with UV detection. The use of Carbopack B resulted in good recoveries of the polar metabolites even from large sample volumes (1 L). Absolute recoveries from spiked surface and groundwater samples ranged between 76 and 100% for the PCs, between 41 and 91% for the OXAs, and between 47 and 96% for the ESAs. The maximum standard deviation of the absolute recoveries was 12%. The method detection limits are between 1 and 8 ng/L for the PCs, between 1 and 7 ng/L for the OXAs, and between 10 and 90 ng/L for the ESAs.

Solar Flare Prediction Science-to-Operations: the ESA/SSA SWE A-EFFort Service

NASA Astrophysics Data System (ADS)

Georgoulis, Manolis K.; Tziotziou, Konstantinos; Themelis, Konstantinos; Magiati, Margarita; Angelopoulou, Georgia

2016-07-01

We attempt a synoptical overview of the scientific origins of the Athens Effective Solar Flare Forecasting (A-EFFort) utility and the actions taken toward transitioning it into a pre-operational service of ESA's Space Situational Awareness (SSA) Programme. The preferred method for solar flare prediction, as well as key efforts to make it function in a fully automated environment by coupling calculations with near-realtime data-downloading protocols (from the Solar Dynamics Observatory [SDO] mission), pattern recognition (solar active-region identification) and optimization (magnetic connectivity by simulated annealing) will be highlighted. In addition, the entire validation process of the service will be described, with its results presented. We will conclude by stressing the need for across-the-board efforts and synergistic work in order to bring science of potentially limited/restricted interest into realizing a much broader impact and serving the best public interests. The above presentation was partially supported by the ESA/SSA SWE A-EFFort project, ESA Contract No. 4000111994/14/D/MRP. Special thanks go to the ESA Project Officers R. Keil, A. Glover, and J.-P. Luntama (ESOC), M. Bobra and C. Balmer of the SDO/HMI team at Stanford University, and M. Zoulias at the RCAAM of the Academy of Athens for valuable technical help.

Joint NASA-ESA Outer Planet Mission study overview

NASA Astrophysics Data System (ADS)

Lebreton, J.-P.; Niebur, C.; Cutts, J.; Falkner, P.; Greeley, R.; Lunine, J.; Blanc, M.; Coustenis, A.; Pappalardo, R.; Matson, D.; Clark, K.; Reh, K.; Stankov, A.; Erd, C.; Beauchamp, P.

2009-04-01

In 2008, ESA and NASA performed joint studies of two highly capable scientific missions to the outer planets: the Europa Jupiter System Mission (EJSM) and the Titan Saturn System Mission (TSSM). Joint Science Definition Teams (JSDTs) were formed with U.S. and European membership to guide study activities that were conducted collaboratively by engineering teams working on both sides of the Atlantic. EJSM comprises the Jupiter Europa Orbiter (JEO) that would be provided by NASA and the Jupiter Ganymede Orbiter (JGO) that would be provided by ESA. Both spacecraft would be launched independently in 2020, and arrive 6 years later for a 3-4 year mission within the Jupiter System. Both orbiters would explore Jupiter's system on trajectories that include flybys of Io (JEO only), Europa (JEO only), Ganymede and Callisto. The operation of JEO would culminate in orbit around Europa while that of JGO would culminate in orbit around Ganymede. Synergistic and coordinated observations would be planned. The Titan Saturn System Mission (TSSM) comprises a Titan Orbiter provided by NASA that would carry two Titan in situ elements provided by ESA: the montgolfière and the lake lander. The mission would launch in 2020 and arrive 9 years later for a 4-year duration in the Saturn system. Following delivery of the ESA in situ elements to Titan, the Titan Orbiter would explore the Saturn system via a 2-year tour that includes Enceladus and Titan flybys. The montgolfière would last at least 6-12 months at Titan and the lake lander 8-10 hours. Following the Saturn system tour, the Titan Orbiter would culminate in a ~2-year orbit around Titan. Synergistic and coordinated observations would be planned between the orbiter and in situ elements. The ESA contribution to this joint endeavor will be implemented as the first Cosmic Vision Large-class (L1) mission; the NASA contribution will be implemented as the Outer Planet Flagship Mission. The contribution to each mission is being reviewed and evaluated by each agency between November 2008 and January 2009, and a joint decision as to which destination has been selected is expected to be announced in February 2009. The ESA Cosmic Vision selection process includes two additional competitive steps (that include two competing astronomy missions) before its contribution to the selected Outer Planet Mission is confirmed in 2012. NASA expects to proceed with the initial implementation of the mission in FY2009, while full implementation will start in FY2013, in line with ESA Cosmic Vision schedule. Should ESA select an astronomy mission instead, NASA would proceed in 2013 with the implementation of a NASA-only mission concept. This presentation will provide an overview of the selected Outer Planet Mission and outline the next steps towards its implementation.

New water and remote galaxies complete ISO's observations

NASA Astrophysics Data System (ADS)

ISO's operational teams at ESA's ground station at Villafranca near Madrid have been hurrying to provide the world's astronomers with as many observations as possible. They have long anticipated the exhaustion of ISO's vital supply of liquid helium, which cooled the infrared telescope and its instruments to their operating temperatures, close to absolute zero. Two weeks after ISO was put into orbit on 17 November 1995 by an Ariane 44P launcher, the external parts of the cooling system had settled to the operating temperature. The specification required that ISO should then operate for at least 18 months -- implying that operations might have to end in May 1997. Thanks to superb engineering by European industry, which built the spacecraft and its super-cool telescope, ISO has given astronomers almost a year longer than that. During the extra time the count of ISO's observations of cosmic objects has risen from 16,000 to about 26,000. Among the benefits of ISO's longevity has been the chance to examine an important region of the sky, in and around the constellation of Orion. This was not accessible in the nominal mission but has now been observed in two periods. Four inter national teams, supported by national funding agencies, supplied the instruments to analyse the infrared rays received by ISO's telescope. The principal investigators leading the teams are Dietrich Lemke (Heidelberg, Germany) for the versatile photometer ISOPHOT, Catherine Cesarsky (Saclay, France) for the camera ISOCAM, Thijs de Graauw (Groningen, the Netherlands) for the Short Wavelength Spectrometer SWS, and Peter Clegg (London, UK) for the Long Wavelength Spectrometer LWS. Water vapour on Titan A big difference between ISO and the only previous infrared astronomy satellite (IRAS 1983) has been its ability to examine individual objects across a wide range of accurately defined infrared wavelengths. Many spectra showing patterns of intensities at the different wavelengths have enabled astronomers to deduce the presence of diverse materials in interstellar space, in the surroundings of stars, and in other galaxies. As previously reported, ISO has identified stony materials, tarry compounds of carbon, and vapours and ices like water and carbon monoxide. Together they give the first clear picture of how Mother Nature prepares, from elements manufactured in stars, the ingredients needed for planets and for life itself. Particularly striking for the human imagination are ISO's repeated discoveries of water in the deserts of space. They encourage expectations of life elsewhere in the Universe. Water has turned up around dying stars, newborn stars, in the general interstellar medium, in the atmospheres of the outer planets and in other galaxies too. A link to the Earth's oceans and the water we live by comes in the water- ice long known to be a major ingredient of comets, which are relics from the era of planet-building. A further link to the investigation of the origin of life is the apparent detection of water vapour in the mysterious atmosphere of Saturn's largest moon, Titan. A preliminary announcement comes from an international team headed by Athena Coustenis of Paris Observatory and Alberto Salama of the ISO Science Operations Center at Villafranca. The team used ISO's Short Wavelength Spectrometer during several hours of observations last December, when Titan was at its farthest from Saturn as seen by ISO. Emissions at wavelengths of 39 and 44 microns showed up, as an expected signature of water vapour. The news will excite the scientists involved in ESA's probe Huygens, launched last year aboard NASA's Cassini spacecraft. It will parachute into Titan's atmosphere to see what the chemistry of the Earth may have been like before life began. "Water vapour makes Titan much richer," comments Athena Coustenis. "We knew there was carbon monoxide and carbon dioxide in Titan's atmosphere, so we expected water vapour too. Now that we believe we've found it, we can expect to better understand the organic chemistry taking place on Titan and also the sources of oxygen in the Saturnian System. After ISO, the Huygens probe will reveal the actual degree of complexity in a mixture of elaborate organic molecules closely resembling the chemical soup on the young Earth." Ballet corps of young stars Infrared images of the spectacular Orion star-forming regions, at a distance of approximately 1500 light years, are bonuses from ISO's extended life. In the Horsehead Nebula, visible light shows a large dark dust cloud from which a black wisp shaped like a horse's head protrudes into a luminous cloud of gas. When seen by ISO's camera ISOCAM, dense parts of the dusty region appear as shiny filaments and the horse's head almost disappears. Young stars are detected in the horse's forehead and in the nearby nebula NGC 2023. Other well-known nebulae in the Orion region include NGC 2068 and NGC 2071. Emission by carbon compounds (polycyclic aromatic hydrocarbons or PAH) makes the infrared nebulae spectacular, as seen by ISOCAM. And thanks to ISOCAM's sensitivity and the ability of infrared rays to penetrate a dust cloud better than visible light, ballet corps of young stars appear on the stage, seen as spots in the centre of these two nebulae. This is not surprising, because the dense, dusty regions called molecular clouds are often the breeding grounds of new stars, but ISOCAM detects fainter and more obscured objects. "We have used ISOCAM to make a census of families of young stars," comment Lennart Nordh and Göran Olofsson of Stockholm University, who lead a team of astronomers from Sweden, France, Italy, the UK and ESA. "By comparing the intensities of the point-like objects at different infrared wavelengths we can efficiently identify the ensemble of young stars still embedded in its parental molecular clouds." From their study of ISO's early observations of four star-forming clouds, the astronomers report the detection of small stars. "Almost 300 young stars have been identified to date, many of which were previously not recognized," Nordh and Olofsson say. "Most of the latter objects have luminosities 10-100 times lower than revealed by earlier observations. Our preliminary analysis indicates that at least ten per cent of the embedded young stars will become small brown dwarfs, or ownerless super-planets, less than one-tenth of the mass of the Sun." Colliding galaxies Some galaxies are unusually bright in the infrared because of cosmic traffic accidents that bring them into collision with other galaxies. The result is a frenzy of star formation called a starburst. The explosion of short-lived stars then creates a pall of warm dust which ISO observes in the infrared. The relative intensities of different wavelengths enable astronomers to distinguish starburst events from other sources of strong infrared rays, such as the environment of a black hole in the nucleus of a galaxy. Collisions and starbursts play an important part in the evolution of galaxies. A famous pair of colliding galaxies called the Antennae was one of the first objects to be examined by ISO. Continuing study of the Antennae over the past two years has revealed a clear picture of a starburst occurring exactly where the dense disks of the galaxies intersect. The nuclei of the two galaxies are plainly distinguished too. Centaurus A is a galaxy that first attracted the attention of astronomers by its strong of radio emissions. In its visible appearance, a large, round (elliptical) galaxy has a dark band across its face. This too turns out to be the result of a galactic collision. The dark band is a flat, disk-shaped galaxy seen almost edge-on. Centaurus A is the nearest case of a phenomenon seen elsewhere by ISO, in which a flat galaxy has merged with an elliptical galaxy while preserving its flat configuration. ISOCAM gives an image of Centaurus A in which the disk galaxy is the more conspicuous object. The orientation of the disk becomes clear. It is at right angles to the axis of the radio-emitting regions, which are powered by jets of electrons driven by a black hole in the centre of the galaxy. Excited emissions detected by ISO's Short Wavelength Spectrometer also indicate the presence of an active black hole. "Centaurus A is an example of ISO's magic," says Catherine Cesarsky of CEA Saclay in France, leader of the ISOCAM instrument team. "It transforms opaque clouds seen by visible light into glowing scenes in the infrared. The same thing happens in dust clouds hiding newborn stars, and on a huge scale in dusty starburst galaxies -- which become infrared beacons lighting our way deep into the Universe." Distant galaxies seen through the holes in the sky When ISO was launched, one of the hopes for the space observatory was that it would detect galaxies made luminous by starburst events, or by black-hole activity, very far away in space and therefore far back in time. Dust in our own Milky Way Galaxy usually obscures the remotest and faintest galaxies. But when they look northwards and southwards, at right-angles to the disk of the Milky Way, astronomers find holes in the dust clouds through which distant galaxies are discernible. Both for ISO and the Hubble Space Telescope these holes have been special targets for observations with long exposures, to reveal faint galaxies. ISOCAM results through the northern hole, by a Japanese-led team, were reported last year in an ESA Information Note (25.97) and a picture release (ESA/ISO 97:8/1). They revealed many infrared-luminous galaxies billions of light- years away, from an era corresponding with about half the present age of the Universe. Even more distant and earlier galaxies may be present in ISO's observations, including some objects not yet seen by visible light. Results released at the London press briefing on ISO include "deep field" examinations by groups of astronomers led by Catherine Cesarsky of CEA Saclay and Michael Rowan Robinson of Imperial College, London, analysing the northern and southern images respectively. In the northern deep field, when ISOCAM observations are superimposed on a Hubble picture of the same region, they pick out spiral galaxies experiencing starbursts. A different signature comes from large elliptical galaxies whose visible light has been shifted into the infrared by the expansion of the Universe. The astronomers estimate that some of the objects seen by ISOCAM are so far away that the Universe was only one-third of its present age when they emitted the radiation seen today. The first ISO images from the opposite direction in the sky, in the southern deep field, show similar objects, again at great distances. A preliminary analysis indicates the presence of of 30-40 remote galaxies seen at a wavelength of 7 microns and 22-30 at 15 microns. One interesting source, bright in the infrared, is not seen by visible light even in a prolonged examination by the CTIO 4-metre telescope in Chile (A. Walker). Astronomers suspect that this object is undergoing an especially violent period of star formation. The interpretation can be checked when Hubble and other telescopes have a chance to examine this scene. Besides illuminating the evolution of the galaxies, ISO's deep field results are encouraging for scientists planning another of ESA's astronomical space projects, FIRST. Its longer wavelengths will penetrate even deeper into the unknown. Non-stop discoveries The extended life was not the only outcome that made ISO a triumph for ESA, European industry and those responsible for its operations. The pointing accuracy of the telescope turned out to be ten times better than required in the specification and its jitter was one-fifth of what was considered tolerable. Stray light in the optical system was too small to measure. The scheduling systems achieved science observations for 90-95 per cent of the available time. Much of the rest of the time, when ISO was turning to new targets, was spent in mapping parts of the sky at a wavelength of 200 microns. Activity concerning ISO will continue at the Villafranca ground station until the year 2001, long after the completion of the observational phase of the mission. During the space operations, the main objective was to make as many observations as possible. Thorough analysis and interpretation of the results will take several years. "We still have plenty to do," says Martin Kessler, ESA's project scientist for ISO. "Our team at Villafranca is preparing a complete archive of ISO data on 500-1000 compact disks, after reprocessing with improved software. We'll release part of this archive to the world-wide astronomical community in the autumn of this year, and the rest in 1999. We shall also advise the astronomers who have used ISO, about the particular requirements for handling the data from each instrument, and we'll be doing some astronomy ourselves. There are far more results still to come from ISO." Europe's infrared astronomers are already busy preparing ESA's FIRST and Planck missions, due for launch early in the new century. FIRST will observe long infrared wavelengths in the sub-millimetre range, while Planck will map the cosmic microwave background far more accurately than NASA's COBE mission did, to reveal the clumps of matter from which galaxies evolved. Also under study by ESA is a possible interferometer mission using a combination of infrared telescopes. In principle it might observe and characterize planets in orbit around other stars. Meanwhile, Europe's space astronomy programme continues apace in other directions. ESA's participation in the Hubble Space Telescope and its eventual successor assures access to those important instruments for Europe's astronomers. The release in 1997 of the catalogues from ESA's unique star-mapping mission Hipparcos provided all astronomer with amazingly precise data for sizing up the stars and the wider Universe. Next year will see the launch of ESA's XMM satellite to observe X-rays from the Universe with the most ingenious and sensitive X-ray telescopes ever made. It will be followed by Integral in 2001, which will investigate cosmic gamma-rays with clever imaging devices called coded masks, and ultra-sensitive detectors. "Our aim in space astronomy is that every ESA mission should be the best in the world at the time of its launch," says Roger Bonnet, ESA's director of science. "ISO is a shining example. It has revolutionized infrared astronomy. It has given us wonderful insights into cool and hidden places in the Universe, and into the origins of water and other materials to which we owe our very existence. A mission of this scale and complexity was feasible for Europe only through the multinational collaboration coordinated by ESA." See ISO's results on the World Wide Web, or on a CD Immediate access to information about ISO and its results, including a picture gallery, is available via the Internet: http://isowww.estec.esa.nl For the assistance of journalists, ESA's ISO team has also prepared a compact disk containing the same information as the website, together with previously published information about ISO and its results. For further information, contact ESA Public Relations Division Tel: +33.(0)1.53.69.71.55 Fax: +33(0)1.53.69.76.90

Comparative Science and Space Weather Around the Heliosphere

NASA Astrophysics Data System (ADS)

Grande, Manuel; Andre, Nicolas; COSPAR/ILWS Roadmap Team

2016-10-01

Space weather refers to the variable state of the coupled space environment related to changing conditions on the Sun and in the terrestrial atmosphere. The presentation will focus on the critical missing knowledge or observables needed to significantly advance our modelling and forecasting capabilities throughout the solar system putting these in perspective to the recommendations in the recent COSPAR/ILWS roadmap. The COSPAR/ILWS RoadMap focuses on high-priority challenges in key areas of research leading to a better understanding of the space environment and a demonstrable improvement in the provision of timely, reliable information pertinent to effects on civilian space- and ground-based systems, for all stakeholders around the world. The RoadMap prioritizes those advances that can be made on short, intermediate and decadal time scales, identifying gaps and opportunities from a predominantly, but not exclusively, geocentric perspective. While discussion of space weather effects has so far largely been concerned to the near-Earth environment, there are significant present and future applications to the locations beyond, and to other planets. Most obviously, perhaps, are the radiation hazards experienced by astronauts on the way to, and on the surface of, the Moon and Mars. Indeed, the environment experienced by planetary spacecraft in transit and at their destinations is of course critical to their design and successful operation. The case of forthcoming missions to Jupiter and Europa is an extreme example. Moreover, such craft can provide information which in turn increases our understanding of geospace. One initiative is that under Horizon 2020, Europlanet RI will set up a Europlanet Planetary Space Weather Service (PSWS). PSWS will make five entirely new `toolkits' accessible to the research community and to industrial partners planning for space missions: - a General planetary space weather toolkit; Mars (in support of the ESA ExoMars missions to be launched in 2016 and 2018); comets (building on the success of the ESA Rosetta mission); outer planets (in preparation for the ESA JUICE mission to be launched in 2022), as well as a novel "event-diary" toolkit aiming at predicting and detecting planetary events like meteor impacts

Comparative science and space weather around the heliosphere

NASA Astrophysics Data System (ADS)

Grande, Manuel

2016-07-01

Space weather refers to the variable state of the coupled space environment related to changing conditions on the Sun and in the terrestrial atmosphere. The presentation will focus on the critical missing knowledge or observables needed to significantly advance our modelling and forecasting capabilities throughout the solar system putting these in perspective to the recommendations in the recent COSPAR/ILWS roadmap. The COSPAR/ILWS RoadMap focuses on high-priority challenges in key areas of research leading to a better understanding of the space environment and a demonstrable improvement in the provision of timely, reliable information pertinent to effects on civilian space- and ground-based systems, for all stakeholders around the world. The RoadMap prioritizes those advances that can be made on short, intermediate and decadal time scales, identifying gaps and opportunities from a predominantly, but not exclusively, geocentric perspective. While discussion of space weather effects has so far largely been confined to the near-Earth environment, there are significant present and future applications to the locations beyond, and to other planets. Most obviously, perhaps, are the radiation hazards experienced by astronauts on the way to, and on the surface of, the Moon and Mars. Indeed, the environment experienced by planetary spacecraft in transit and at their destinations is of course critical to their design and successful operation. The case of forthcoming missions to Jupiter and Europa is an extreme example. Moreover, such craft can provide information which in turn increases our understanding of geospace. One initiative is that under Horizon 2020, Europlanet RI will set up a Europlanet Planetary Space Weather Service (PSWS). PSWS will make five entirely new 'toolkits' accessible to the research community and to industrial partners planning for space missions: - a General planetary space weather toolkit; Mars (in support of the ESA ExoMars missions to be launched in 2016 and 2018); comets (building on the success of the ESA Rosetta mission); outer planets (in preparation for the ESA JUICE mission to be launched in 2022), as well as a novel "event-diary" toolkit aiming at predicting and detecting planetary events like meteor impacts

Self-monitoring Using Mobile Phones in the Early Stages of Adolescent Depression: Randomized Controlled Trial

PubMed Central

Reid, Sophie Caroline; Crooke, Alexander Hew Dale; Khor, Angela; Hearps, Stephen John Charles; Jorm, Anthony Francis; Sanci, Lena; Patton, George

2012-01-01

Background The stepped-care approach, where people with early symptoms of depression are stepped up from low-intensity interventions to higher-level interventions as needed, has the potential to assist many people with mild depressive symptoms. Self-monitoring techniques assist people to understand their mental health symptoms by increasing their emotional self-awareness (ESA) and can be easily distributed on mobile phones at low cost. Increasing ESA is an important first step in psychotherapy and has the potential to intervene before mild depressive symptoms progress to major depressive disorder. In this secondary analysis we examined a mobile phone self-monitoring tool used by young people experiencing mild or more depressive symptoms to investigate the relationships between self-monitoring, ESA, and depression. Objectives We tested two main hypotheses: (1) people who monitored their mood, stress, and coping strategies would have increased ESA from pretest to 6-week follow-up compared with an attention comparison group, and (2) an increase in ESA would predict a decrease in depressive symptoms. Methods We recruited patients aged 14 to 24 years from rural and metropolitan general practices. Eligible participants were identified as having mild or more mental health concerns by their general practitioner. Participants were randomly assigned to either the intervention group (where mood, stress, and daily activities were monitored) or the attention comparison group (where only daily activities were monitored), and both groups self-monitored for 2 to 4 weeks. Randomization was carried out electronically via random seed generation, by an in-house computer programmer; therefore, general practitioners, participants, and researchers were blinded to group allocation at randomization. Participants completed pretest, posttest, and 6-week follow-up measures of the Depression Anxiety Stress Scale and the ESA Scale. We estimated a parallel process latent growth curve model (LGCM) using Mplus to test the indirect effect of the intervention on depressive symptoms via the mediator ESA, and calculated 95% bias-corrected bootstrapping confidence intervals (CIs). Results Of the 163 participants assessed for eligibility, 118 were randomly assigned and 114 were included in analyses (68 in the intervention group and 46 in the comparison group). A parallel process LGCM estimated the indirect effect of the intervention on depressive symptoms via ESA and was shown to be statistically significant based on the 95% bias-corrected bootstrapping CIs not containing zero (–6.366 to –0.029). The proportion of the maximum possible indirect effect estimated was κ2 =.54 (95% CI .426–.640). Conclusions This study supported the hypothesis that self-monitoring increases ESA, which in turn decreases depressive symptoms for young people with mild or more depressive symptoms. Mobile phone self-monitoring programs are ideally suited to first-step intervention programs for depression in the stepped-care approach, particularly when ESA is targeted as a mediating factor. Trial Registration ClinicalTrials.gov NCT00794222; http://clinicaltrials.gov/ct2/show/NCT00794222 (Archived by WebCite at http://www.webcitation.org/65lldW34k) PMID:22732135

Feasibility of performing space surveillance tasks with a proposed space-based optical architecture

NASA Astrophysics Data System (ADS)

Flohrer, Tim; Krag, Holger; Klinkrad, Heiner; Schildknecht, Thomas

Under ESA contract an industrial consortium including Aboa Space Research Oy (ASRO), the Astronomical Institute of the University of Bern (AIUB), and the Dutch National Aerospace Laboratory (NLR), proposed the observation concept, developed a suitable sensor architecture, and assessed the performance of a space-based optical (SBO) telescope in 2005. The goal of the SBO instrumentation was to analyse how the existing knowledge gap in the space debris population in the millimetre and centimetre regime may be closed by means of a passive op-tical instrument. SBO was requested to provide statistical information on the space debris population, in terms of number of objects and size distribution. The SBO was considered to be a cost-efficient instrumentation of 20 cm aperture and 6 deg field-of-view with flexible integration requirements. It should be possible to integrate the SBO easily as a secondary payload on satellites launched into low-Earth orbits (LEO), or into geostationary orbit (GEO). Thus the selected mission concept only allowed for fix-mounted telescopes, and the pointing direction could be requested freely. It was shown in the performance analysis that the statistical information on small-sized space debris can only be collected if the observation ranges are comparatively small. Two of the most promising concepts were to observe objects in LEO from a sensor placed into a sun-synchronous LEO, while objects in GEO should be observed from a GEO satellite. Since 2007 ESA focuses space surveillance and tracking activities in the Space Situational Awareness (SSA) preparatory program. Ground-based radars and optical telescopes are stud-ied for the build-up and to maintenance of a catalogue of objects. In this paper we analyse how the SBO architecture could contribute to the space surveillance tasks survey and tracking. We assume that the SBO instrumentation is placed into a circular sun-synchronous orbit at 800 km altitude. We discuss the observation conditions of objects at higher altitude, such as GEO and Medium-Earth Orbits (MEO). Of particular interest are the radiometric performance from which we derive the detectable object diameters, the coverage of a reference population, and the covered arc lengths of individual objects. The latter is of particular interest for the simu-lation of the orbit determination, correlation, and cataloguing. Assuming realistic noise levels known from the SBO design we simulate first orbit determination of unknown objects (surveys) and orbit improvements (tracking) for sample objects. We use a simulation environment that comprises the ESA Program for Radar and Optical Observation Forecasting (PROOF) in the version 2005 and AIUB's program system CelMech. ESA's MASTER-2005 serves as reference population for all analyses.

The effect of point-of-care personal digital assistant use on resident documentation discrepancies.

PubMed

Carroll, Aaron E; Tarczy-Hornoch, Peter; O'Reilly, Eamon; Christakis, Dimitri A

2004-03-01

We recently found documentation discrepancies in 60% of resident daily-progress notes with respect to patient weight, medications, or vascular lines. To what extent information systems can decrease such discrepancies is unknown. To determine whether a point-of-care personal digital assistant (PDA)-based patient record and charting system could reduce the number of resident progress-note documentation discrepancies in a neonatal intensive care unit (NICU). We conducted a before-and-after trial in an academic NICU. Our intervention was a PDA-based patient record and charting system used by all NICU resident physicians over the study period. We analyzed all resident daily-progress notes from 40 randomly selected days over 4 months in both the baseline and intervention periods. Using predefined reference standards, we determined the accuracy of recorded information for patient weights, medications, and vascular lines. Logistic and Poisson regression were used in analyses to control for potential confounding factors. A total of 339 progress notes in the baseline period and 432 progress notes in the intervention period were reviewed. When controlling for covariates in the regression, there were significantly fewer documentation discrepancies of patient weights in notes written by using the PDA system (14.4%-4.4% of notes; odds ratio [OR]: 0.29; 95% confidence interval [CI]: 0.15-0.56). When using the PDA system, there were no significant changes in the numbers of notes with documentation discrepancies of medications (27.7%-17.1% of notes; OR: 0.63; 95% CI: 0.35-1.13) or vascular lines (33.6%-36.1% of notes; OR: 1.11; 95% CI: 0.66-1.87). The use of our PDA-based point-of-care patient record and charting system showed a modest benefit in reducing the number of documentation discrepancies in resident daily-progress notes. Further study of PDAs in information systems is warranted before they are widely adopted.

Earth Sensor Assembly for the Tropical Rainfall Measuring Mission Observatory

NASA Technical Reports Server (NTRS)

Prince, Steven S.; Hoover, James M.

1995-01-01

EDO Corporation/Barnes Engineering Division (BED) has provided the Tropical Rainfall Measurement Mission (TRMM) Earth Sensor Assembly (ESA), a key element in the TRMM spacecraft's attitude control system. This report documents the history, design, fabrication, assembly, and test of the ESA.

ESA PASSAGES experiment

NASA Image and Video Library

2011-10-06

ISS029-E-021636 (6 Oct. 2011) --- Japan Aerospace Exploration Agency astronaut Satoshi Furukawa, Expedition 29 flight engineer, uses Neurospat hardware to perform a science session with the European Space Agency PASSAGES experiment in the Columbus laboratory of the International Space Station. PASSAGES is designed to test how astronauts interpret visual information in weightlessness. It aims at studying the effects of microgravity on the use of the 'Eye-Height' strategy for estimating allowed actions in an environment, and whether this could possibly decrease after a long exposure to weightlessness.

ESA PASSAGES experiment

NASA Image and Video Library

2011-10-06

ISS029-E-021641 (6 Oct. 2011) --- NASA astronaut Mike Fossum, Expedition 29 commander, uses Neurospat hardware to perform a science session with the European Space Agency PASSAGES experiment in the Columbus laboratory of the International Space Station. PASSAGES is designed to test how astronauts interpret visual information in weightlessness. It aims at studying the effects of microgravity on the use of the 'Eye-Height' strategy for estimating allowed actions in an environment, and whether this could possibly decrease after a long exposure to weightlessness.

Environmental Assessment of the Long Endurance Multi-Intelligence Vehicle (LEMV) Program

DTIC Science & Technology

2012-12-01

cleaner, hair dryer 70 Intrusive; interferes with telephone conversation Normal conversation 50-65 Quiet Office 50-60 Comfortable hearing levels are...consuha1ion pursuan11o the ESA is requ ired . If add itional information on federal ly listed species becomes av;lilable. or if prOJCC I plans change, this...delemlination may be reconsidered. Please refer to this office’s web site :11 hiiJ>:I/www.fws.!!<Jv/nonheastinj fieldoflice/Endangered/ for further

Data Recovery from SCATHA Satellite

NASA Technical Reports Server (NTRS)

Fennell, J. F.; Boyd, G. M.; Redding, M. T.; McNab, M. C.

1997-01-01

This document gives a brief description of the SCATHA (P78-2) satellite and consolidates into one location information relevant to the generation of the SCATHA Summary Data parameters for the European Space Agency (ESA), under ESTEC Contract No. 11006/94/NL/CC, and the National Aeronautics and Space Administration (NASA), under Grant No. NAGW-414 1. Included are descriptions of the instruments from which the Summary Data parameters are generated, their derivation, and archival. Any questions pertaining to the Summary Data parameters should be directed to Dr. Joseph Fennell.

Technical Data Interoperability (TDI) Pathfinder Via Emerging Standards

NASA Technical Reports Server (NTRS)

Conroy, Mike; Gill, Paul; Hill, Bradley; Ibach, Brandon; Jones, Corey; Ungar, David; Barch, Jeffrey; Ingalls, John; Jacoby, Joseph; Manning, Josh;

Bubbles: Films, Foams & Fizz. Ideas in Science. Notes for Teachers.

ERIC Educational Resources Information Center

Murphy, Pat, Ed.

Five activities dealing with bubbles are presented. Information provided with the activities includes introductory and/or background information; notes on pre-activity preparations; lists of science themes and skills fostered; time frame; list of materials needed; student procedures; and instructional strategies. A teaching guide with detailed…

77 FR 57576 - Notice of Proposed Information Collection to OMB and Comment Request: Legal Instructions...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-18

... connection with the assignment, legal documents (e.g., mortgage, mortgage note, security agreement, title... Information Collection to OMB and Comment Request: Legal Instructions Concerning Applications for Full... mortgages to HUD. In connection with the assignment, legal documents (e.g., mortgage, mortgage note...

Mapping the Idea: A Notetaking System.

ERIC Educational Resources Information Center

Driskell, Jeanette

"Mapping" is a note-taking technique by which students use visual cues to isolate, emphasize, and group information meaningfully. Features of this technique include: organizing the note page laterally, so that general topics are on the left side and supportive information is on the right side; separating topics by horizontal lines;…

Deaf/hard-of-hearing and other postsecondary learners' retention of STEM content with tablet computer-based notes.

PubMed

Stinson, Michael S; Elliot, Lisa B; Easton, Donna

2014-04-01

Four groups of postsecondary students, 25 who were deaf/hard of hearing (D/HH), 25 with a learning disability, 25 who were English language learners (ELLs), and 25 without an identified disability studied notes that included text and graphical information based on a physics or a marine biology lecture. The latter 3 groups were normally hearing. All groups had higher scores on post- than on pretests for each lecture, with each group showing generally similar gains in amount of material learned from the pretest to the posttest. For each lecture, the D/HH students scored lower on the pre- and posttests than the other 3 groups of participants. Results indicated that students acquired measurable amounts of information from studying these types of notes for relatively short periods and that the notes have equal potential to support the acquisition of information by each of these groups of students.

Hemodynamic monitoring and management in patients undergoing high risk surgery: a survey among North American and European anesthesiologists

PubMed Central

2011-01-01

Introduction Several studies have demonstrated that perioperative hemodynamic optimization has the ability to improve postoperative outcome in high-risk surgical patients. All of these studies aimed at optimizing cardiac output and/or oxygen delivery in the perioperative period. We conducted a survey with the American Society of Anesthesiologists (ASA) and the European Society of Anaesthesiology (ESA) to assess current hemodynamic management practices in patients undergoing high-risk surgery in Europe and in the United States. Methods A survey including 33 specific questions was emailed to 2,500 randomly selected active members of the ASA and to active ESA members. Results Overall, 368 questionnaires were completed, 57.1% from ASA and 42.9% from ESA members. Cardiac output is monitored by only 34% of ASA and ESA respondents (P = 0.49) while central venous pressure is monitored by 73% of ASA respondents and 84% of ESA respondents (P < 0.01). Specifically, the pulmonary artery catheter is being used much more frequently in the US than in Europe in the setup of high-risk surgery (85.1% vs. 55.3% respectively, P < 0.001). Clinical experience, blood pressure, central venous pressure, and urine output are the most widely indicators of volume expansion. Finally, 86.5% of ASA respondents and 98.1% of ESA respondents believe that their current hemodynamic management could be improved. Conclusions In conclusion, these results point to a considerable gap between the accumulating evidence about the benefits of perioperative hemodynamic optimization and the available technologies that may facilitate its clinical implementation, and clinical practices in both Europe and the United States. PMID:21843353

Chemotherapy-induced anemia and oncologist perception on treatment: results of a web-based survey.

PubMed

Cortinovis, Diego; Beretta, Giordano; Piazza, Elena; Luchena, Giovanna; Aglione, Stefania; Bertolini, Alessandro; Buzzoni, Roberto; Cabiddu, Mary; Carnaghi, Carlo; Danova, Marco; Farina, Gabriella; Ferrari, Vittorio; Frascaroli, Mara; Reni, Michele; Tansini, Giuseppe

2013-01-01

Anemia prevalence and incidence in chemotherapy-treated patients is high. Erythropoiesis-stimulating agents (ESAs) are frequently employed in the management of chemotherapy-induced anemia. However, other treatments such as red blood transfusion or iron supplementation are normally used. Recent international guidelines raised some concern about ESAs employment with a possible impact in chemotherapy-induced anemia management and changes in clinical practice behavior. To evaluate opinions about chemotherapy-induced anemia clinical management preference, the Associazione Italiana Oncologia Medica (AIOM) Lombardy section coordinators sent via email a 12-item questionnaire about their knowledge on CIA and usual therapeutic strategies to manage this adverse event to AIOM Lombardy onco-hematologist members. From January 2011 to March 2011, 81 questionnaires were collected with an approximated share of 30%. The survey was completed mainly by oncologists (91%) aged 35-50 years (50%). Chemotherapy-induced anemia was considered to have clinical impact in changing cancer therapeutic strategy by nearly 60% of the respondents. ESAs were administered largely (80%) with concomitant iron supplementation in 52%; 38% jointly used blood transfusion as part of the therapy. Nearly 20% of those who replied correctly employed transferrin saturation levels as a marker to guide iron supplementation. Physician prescribers strictly followed the guidelines to start and stop ESAs even if 14% were negatively influenced by new ASCO recommendations. ESA biosimilars were considered future substitutes of originators in 45% of the cases. Chemotherapy-induced anemia was perceived as an adverse event with a mild impact on clinical practice. ESAs were largely employed, however the number of transfusions and lack of employment of markers of iron depletion suggested that adherence to guidelines could be theoretically met but with some discordances regarding the most appropriate strategies in daily clinical practice.

A randomized controlled trial evaluating the erythropoiesis stimulating agent sparing potential of a vitamin E-bonded polysulfone dialysis membrane

PubMed Central

Lines, Simon W.; Carter, Angela M.; Dunn, Emma J.; Lindley, Elizabeth J.; Tattersall, James E.; Wright, Mark J.

2014-01-01

Background Vitamin E (VE) bonded polysulfone dialysis membranes have putative erythropoiesis stimulating agent (ESA)-sparing and anti-inflammatory properties based on data from a small number of studies. We sought to investigate this in a large, prospective 12-month randomized controlled trial. Methods Two-hundred and sixty prevalent haemodialysis (HD) patients were randomized to dialysis with VE-bonded polysulfone membranes or non-VE-bonded equivalents. All ESA-dosing was performed by means of a computer-based anaemia management decision support system. Monthly data were used to calculate the ESA resistance index (ERI) and blood tests were performed at baseline, 6 and 12 months for measurement of C-reactive protein (CRP) levels. Results Of the 260 patients, 123 were randomized to dialysis with the VE-membrane and 12-month data was available for 220 patients. At the study population level, no beneficial effect of the VE membranes on the ERI or CRP levels was observed. Post hoc analyses indicated that there was a significant fall in ERI for patients with the highest baseline ESA resistance dialysed with the VE (9.28 [7.70–12.5] versus 7.70 [5.34–12.7] IU/week/kg/g/dL Hb, P = 0.01) but not the control membranes (9.45 [7.62–12.3] versus 8.14 [4.44–15.6] IU/week/kg/g/dL Hb, P = 0.41); this was not attributable to changes in CRP levels. Conclusions Wholesale switching of all chronic HD patients to dialysis with VE-bonded polysulfone membranes appears not to be associated with improvements in ESA-responsiveness or CRP. These membranes may have utility in patients with heightened ESA resistance. PMID:24293660

Sickle Trait in African-American Hemodialysis Patients and Higher Erythropoiesis-Stimulating Agent Dose

PubMed Central

Lacson, Eduardo K.; Kshirsagar, Abhijit V.; Key, Nigel S.; Hogan, Susan L.; Hakim, Raymond M.; Mooney, Ann; Jani, Chinu M.; Johnson, Curtis; Hu, Yichun; Falk, Ronald J.; Lazarus, J. Michael

2014-01-01

African Americans require higher doses of erythropoiesis-stimulating agents (ESAs) during dialysis to manage anemia, but the influence of sickle cell trait and other hemoglobinopathy traits on anemia in dialysis patients has not been adequately evaluated. We performed a cross-sectional study of a large cohort of adult African-American hemodialysis patients in the United States to determine the prevalence of hemoglobinopathy traits and quantify their influence on ESA dosing. Laboratory and clinical data were obtained over 6 months in 2011. Among 5319 African-American patients, 542 (10.2%) patients had sickle cell trait, and 129 (2.4%) patients had hemoglobin C trait; no other hemoglobinopathy traits were present. Sickle cell trait was more common in this cohort than the general African-American population (10.2% versus 6.5%–8.7%, respectively, P<0.05). Among 5002 patients (10.3% sickle cell trait and 2.4% hemoglobin C trait) receiving ESAs, demographic and clinical variables were similar across groups, with achieved hemoglobin levels being nearly identical. Patients with hemoglobinopathy traits received higher median doses of ESA than patients with normal hemoglobin (4737.4 versus 4364.1 units/treatment, respectively, P=0.02). In multivariable analyses, hemoglobinopathy traits associated with 13.2% more ESA per treatment (P=0.001). Within subgroups, sickle cell trait patients received 13.2% (P=0.003) higher dose and hemoglobin C trait patients exhibited a similar difference (12.9%, P=0.12). Sensitivity analyses using weight-based dosing definitions and separate logistic regression models showed comparable associations. Our findings suggest that the presence of sickle cell trait and hemoglobin C trait may explain, at least in part, prior observations of greater ESA doses administered to African-American dialysis patients relative to Caucasian patients. PMID:24459231

Effects of OXPHOS complex deficiencies and ESA dysfunction in working intact skeletal muscle: implications for mitochondrial myopathies.

PubMed

Korzeniewski, Bernard

2015-10-01

The effects of inborn oxidative phosphorylation (OXPHOS) complex deficiencies or possible each-step activation (ESA) dysfunction on the bioenergetic system in working intact skeletal muscle are studied using a computer model of OXPHOS published previously. The curves representing the dependencies of V˙O2 and metabolite concentrations on single complex activity, entire OXPHOS activity or ESA intensity exhibit a characteristic threshold at some OXPHOS complex activity/ESA intensity. This threshold for V˙O2 of single complex activities is significantly lower in intact muscle during moderate and heavy work, than in isolated mitochondria in state 3. Metabolite concentrations and pH in working muscle start to change significantly at much higher OXPHOS complex activities/ESA intensities than V˙O2. The effect of entire OXPHOS deficiency or ESA dysfunction is potentially much stronger than the effect of a single complex deficiency. Implications of these findings for the genesis of mitochondrial myopathies are discussed. It is concluded that V˙O2 in state 3 and its dependence on complex activity in isolated mitochondria is not a universal quantitative determinant of the effect of mitochondrial dysfunctions in vivo. Moderate and severe mitochondria dysfunctions are defined: the former affect significantly only metabolite concentrations and pH, while the latter also decrease significantly V˙O2 in intact skeletal muscle during work. The dysfunction-caused decrease in V˙O2/oxidative ATP synthesis flux, disturbance of metabolite homeostasis, elevated ROS production and anaerobic glycolysis recruitment can account for such mitochondrial myopathy symptoms as muscle weakness, exercise intolerance (exertional fatigue) and lactic acidosis. Copyright © 2015 Elsevier B.V. All rights reserved.

Spain: Success story in space

NASA Astrophysics Data System (ADS)

Longdon, Norman

From the early 1960's, European governments were aware that they had to take part in the exploration, and potential exploitation, of space, or be left behind in a field of high-technology that had far-reaching possibilities. It was also realized that financial and manpower constraints would limit the extent to which individual nations could carry out their own national programs. They, therefor, joined forces in two organizations: the European Space Research Organization (ESRO) and the European Launcher Development Organization (ELDO). By 1975, when the potential of space development had been more fully appreciated, the two organizations were merged into the Europeans Space Agency (ESA) of which Spain was a founding member. ESA looks after the interest of 13 member states, one associated member state (Finland), and one cooperating state (Canada) in the peaceful uses of space. Its programs center around a mandatory core of technological research and space science to which member states contribute on the basis of their Gross National Product. Spain in 1992 contributes 6.46% to this mandatory program budget. The member states then have the chance to join optional programs that include telecommunications, observation of the earth and its environment, space transportation systems, microgravity research, and participation in the European contribution to the International Space Station Freedom. Each government decides whether it is in its interest to join a particular optional program, and the percentage that it wishes to contribute to the budget. Although in the early days of ESA, Spain participated in only a few optional programs, today Spain makes a significant contribution to nearly all of ESA's optional programs. This document presents Spain's contributions to particular ESA Programs and discusses Spain's future involvement in ESA.

Sentinel 2A: the image quality performances at the beginning of its mission

NASA Astrophysics Data System (ADS)

Trémas, T.; Lonjou, V.; Lachérade, S.; Languille, F.; Gaudel-Vacaresse, A.,

2016-09-01

Launched on June 23rd, 2015 from Kourou, Sentinel 2A has been providing images for more than 1 year now. The satellite behavior is very satisfactory and the quality of data fulfills the requirements with comfortable margins. The realization and implementation of the satellite has been realized under the responsibility of ESA, for the European Commission. The In Orbit Commissioning phase lasted 4 months, concluded by a review on October 16th, 2015. At this date, the S2A space segment handover took place from the Project Manager (ESA/ESTEC) to the Mission Manager (ESA/ESRIN). The subset of Image Quality commissioning was delegated by ESA to CNES, referring to the experience of the French Space Agency on previous imagers. This phase lasted 7 months after the launch, extending beyond the IOCR. Actually, some parameters required several months before converging to a stable state. This paper presents the status of the satellite, from an IQ prospective, just before it entered its operational phase. The radiometric and geometric performances are listed, including: the absolute radiometric calibration, the equalization, the SNR, the absolute and the multi-temporal location accuracy. The accomplishment of a part of the Global Reference Image over Europe is evoked as well. The IQ commissioning phase ended on January 28th, 2016. From this date, the monitoring of IQ parameters is under the responsibility of ESA/ESRIN. Nevertheless, CNES continues to support ESA to survey the accuracy of S2A performances. The article ends by dealing with the future of S2A that will work together with S2B by the end of 2016.

Participant Adherence Indicators Predict Changes in Blood Pressure, Anthropometric Measures, and Self-Reported Physical Activity in a Lifestyle Intervention: HUB City Steps

PubMed Central

Thomson, Jessica L.; Landry, Alicia S.; Zoellner, Jamie M.; Connell, Carol; Madson, Michael B.; Molaison, Elaine Fontenot; Yadrick, Kathy

2014-01-01

The objective of this secondary analysis was to evaluate the utility of several participant adherence indicators for predicting changes in clinical, anthropometric, dietary, fitness, and physical activity (PA) outcomes in a lifestyle intervention, HUB City Steps, conducted in a southern, African American cohort in 2010. HUB City Steps was a 6 month, community engaged, multi component, non controlled, intervention targeting hypertension risk factors. Descriptive indicators were constructed using 2 participant adherence measures, education session attendance (ESA) and weekly steps/day pedometer diary submission (PDS), separately and in combination. Analyses, based on data from 269 primarily African American adult participants, included bivariate tests of association and multivariable linear regression to determine significant relationships between 7 adherence indicators and health outcome changes, including clinical, anthropometric, dietary, fitness, and PA measures. ESA indicators were significantly correlated with 4 health outcomes, body mass index (BMI), fat mass, low density lipoprotein (LDL), and PA ( .29≤ r ≤ .23; P<.05). PDS indicators were significantly correlated with PA (r=.27; P<.001). Combination ESA/PDS indicators were significantly correlated with 5 health outcomes, BMI, % body fat (%BF), fat mass, LDL, and PA (r= .26 to .29; P<.05). Results from the multivariate models indicated that the combination ESA/PDS indicators were the most significant predictors of changes for 5 outcomes, %BF, fat mass, LDL diastolic blood pressure (DBP), and PA, while ESA performed best for BMI only. For DBP, a 1 unit increase in the continuous categorical ESA/PDS indicator resulted in .3 mm Hg decrease. Implications for assessing participant adherence in community based, multi component lifestyle intervention research are discussed. PMID:24986913

Characteristics of suicide notes of children and young adolescents: an examination of the notes from suicide victims 15 years and younger.

PubMed

Freuchen, Anne; Grøholt, Berit

2015-04-01

By analysing the suicide notes from suicide victims 15 years and younger, we attempt to gain insight into the process leading to youth suicide and explore the characteristics of the note writers. During a psychological autopsy on 42 youths, we were entrusted with 23 suicide notes in which we explored the themes and compared the note writers to the non-note writers. The key messages were as follows: explain the reason for suicide, declare love and give instructions. The note writers had showed suicidal behaviour more frequently than non-note writers. In the notes from youth suicide victims they present themselves as fully responsible and without confusion or overwhelming despair. The notes are likely equally informative as the notes of older victims. © The Author(s) 2013.