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  1. DAS performance analysis

    SciTech Connect

    Bates, G.; Bodine, S.; Carroll, T.; Keller, M.

    1984-02-01

    This report begins with an overview of the Data Acquisition System (DAS), which supports several of PPPL's experimental devices. Performance measurements which were taken on DAS and the tools used to make them are then described.

  2. DAS User Manual

    NASA Astrophysics Data System (ADS)

    Østensen, Roy

    2008-10-01

    The HELAS Database for AsteroSeismology (DAS) is one of the deliverables of the Work Package NA5: Asteroseismology of the European Coordination Action in Helio- and Asteroseismology (HELAS). The DAS aims to provide easy access to publicly available asteroseismological timeseries data, both photometric and spectroscopic. In particular, the DAS and the HELAS software package FAMIAS are ideally suited to train Master and PhD students in asteroseismic data analysis and to build longterm datasets. The number of stars in the system is still limited and reflects the willingness of data owners to provide their data after publication. Work continues to populate the database with contributions from the community, and at present the number of stars in the database is 82

  3. Das DNA-Puzzle

    NASA Astrophysics Data System (ADS)

    Kirchner, Stefan

    Im Jahre 1953 wurde von James Watson und Francis Crick erstmalig der strukturelle Aufbau der sogenannten DNA (Desoxyribonukleinsäure) beschrieben, welche das Erbgut jedes Lebewesens enthält. Der wesentliche Teil des Erbguts wird dabei durch eine sehr lange Folge der vier Basen Adenin (A), Cytosin (C), Guanin (G) und Thymin (T) codiert. Seit einigen Jahren ist es möglich, die Folge der vier Basen zu einer gegebenen DNA zu bestimmen. Biologen bezeichnen diesen Vorgang als Sequenzierung.

  4. Das Allgemeine Statistische Archiv

    NASA Astrophysics Data System (ADS)

    Rinne, Horst

    Das Allgemeine Statistische Archiv1, nachfolgend kurz Archiv genannt, ist die älteste, ausschließlich der Statistik gewidmete deutschsprachige wissenschaftliche Fachzeitschrift. Sie ist gut zwanzig Jahre älter als die Deutsche Statistische Gesellschaft, zu deren Publikationsorgan sie mit der Gründung der Gesellschaft im Jahre 1911 wurde. Zeitschrift und Gesellschaft blicken auf eine sehr wechselvolle, aber erfolgreiche gemeinsame Geschichte zurück. Die wissenschaftliche Arbeit der Gesellschaft ist im Archiv und seinen Sonderheften für nachfolgende Generationen dokumentiert.

  5. Connecting the Dots in DAS

    ERIC Educational Resources Information Center

    Ford, Tracy

    2012-01-01

    Many institutions implement a distributed antenna system (DAS) as part of a holistic approach to providing better wireless coverage and capacity on campus. A DAS provides wireless service within a particular area or structure via a network of separate antenna nodes that are connected to a common source through fiber or coaxial cable. Because DAS…

  6. MyDas, an extensible Java DAS server.

    PubMed

    Salazar, Gustavo A; García, Leyla J; Jones, Philip; Jimenez, Rafael C; Quinn, Antony F; Jenkinson, Andrew M; Mulder, Nicola; Martin, Maria; Hunter, Sarah; Hermjakob, Henning

    2012-01-01

    A large number of diverse, complex, and distributed data resources are currently available in the Bioinformatics domain. The pace of discovery and the diversity of information means that centralised reference databases like UniProt and Ensembl cannot integrate all potentially relevant information sources. From a user perspective however, centralised access to all relevant information concerning a specific query is essential. The Distributed Annotation System (DAS) defines a communication protocol to exchange annotations on genomic and protein sequences; this standardisation enables clients to retrieve data from a myriad of sources, thus offering centralised access to end-users.We introduce MyDas, a web server that facilitates the publishing of biological annotations according to the DAS specification. It deals with the common functionality requirements of making data available, while also providing an extension mechanism in order to implement the specifics of data store interaction. MyDas allows the user to define where the required information is located along with its structure, and is then responsible for the communication protocol details.

  7. Data Acquisition System(DAS) Sustaining Engineering

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This paper presents general information describing the Data Acquisition System contract, a summary of objectives, tasks performed and completed. The hardware deliverables which are comprised of: 1) Two ground DAS units; 2) Two flight DAS units; 3) Logistic spares; and 4) Shipping containers are described. Also included are the data requirements and scope of the contract.

  8. Bases para la elaboracion de unidades didacticas de calidad en el area de ciencias (Fisica y Quimica 3 deg ESO)

    NASA Astrophysics Data System (ADS)

    Maccioni, Elena Lucia

    Este Trabajo Fin de Master tiene como objeto, el estudio previo de la educacion de la ciencia en la actualidad y mas destacable, del diseno de las unidades didacticas segun las metodologias mas frecuentes aplicadas por los diferentes sistemas educativos en el area de las Ciencias teniendo en cuenta la importancia y el efecto de la psicologia del alumnado y todo ello como no puede ser de otro modo bajo el corse de la Legislacion aplicable, Estatal, Autonomica y europea. Con estos antecedentes, se extrae cuales son las preguntas que deben contestarse en la elaboracion de una unidad didactica de calidad en el contexto, generacional (edad y sexo), del Proyecto Educativo de Centro, y de la Programacion del Departamento, discutiendo y justificando cada uno de los apartados en que estructuradamente dividiremos dicha Unidad, con un formato manejable, util, y dinamico en el tiempo que sea un verdadero instrumento educativo de aula. Teniendo en cuenta estas premisas, se procede a hacer una recopilacion de una misma unidad didactica publicada por diferentes editoriales, elegidas no al azar, sino en funcion de su penetracion editorial en nuestros centros de ESO, siendo las elegidas (SM y Oxford). Las diferentes unidades seleccionadas son analizadas de forma critica, atendiendo a los criterios generales de calidad bajo parametros cientificos y normativos, concluyendo con la aportacion final que es la redaccion de unas pautas cientifico-pedagogicas, para redactar unidades didacticas de calidad en el area de la Ciencias, en concreto en la Asignatura de Fisica y Quimica de 3º de ESO.

  9. DAS28-CRP and DAS28-ESR cut-offs for high disease activity in rheumatoid arthritis are not interchangeable

    PubMed Central

    Fleischmann, Roy M; van der Heijde, Désirée; Gardiner, Philip V; Szumski, Annette; Marshall, Lisa; Bananis, Eustratios

    2017-01-01

    Background In most patients with rheumatoid arthritis (RA), Disease Activity Score 28-joint count C reactive protein (DAS28-CRP) is lower than DAS28 erythrocyte sedimentation rate (DAS28-ESR), suggesting that use of the DAS28-ESR cut-off to assess high disease activity (HDA) with DAS28-CRP may underestimate the number of patients with HDA. We determined the DAS28-CRP value corresponding to the validated DAS28-ESR cut-off for HDA. Methods Baseline data were pooled from 2 clinical studies evaluating etanercept (ETN) plus methotrexate (MTX) or MTX in early RA; DAS28-CRP and DAS28-ESR were obtained, allowing the determination of the DAS28-CRP HDA value best corresponding to the DAS28-ESR cut-off of >5.1. Results At baseline, as expected, fewer patients had HDA by DAS28-CRP than DAS28-ESR; DAS28-CRP>5.1 and DAS28-ESR>5.1 had only modest agreement (κ coefficients 0.45–0.54). Mean DAS28-CRP and DAS28-ESR were 5.7 and 6.2, respectively, in the ETN+MTX group (n=571), and 6.0 and 6.5 in the MTX group (n=262). A DAS28-CRP cut-off of 4.6 corresponded to a DAS28-ESR cut-off of 5.1. Conclusions We have shown that a DAS28-CRP of 4.6 corresponds to 5.1 for DAS28-ESR. Since this is substantially lower than the DAS28-ESR cut-off of 5.1, using 5.1 as the cut-off for DAS28-CRP underestimates disease activity in RA. Trial registration number NCT00195494; NCT00913458. PMID:28255449

  10. Dasty3, a WEB framework for DAS

    PubMed Central

    Villaveces, Jose M.; Jimenez, Rafael C.; Garcia, Leyla J.; Salazar, Gustavo A.; Gel, Bernat; Mulder, Nicola; Martin, Maria; Garcia, Alexander; Hermjakob, Henning

    2011-01-01

    Motivation: Dasty3 is a highly interactive and extensible Web-based framework. It provides a rich Application Programming Interface upon which it is possible to develop specialized clients capable of retrieving information from DAS sources as well as from data providers not using the DAS protocol. Dasty3 provides significant improvements on previous Web-based frameworks and is implemented using the 1.6 DAS specification. Availability: Dasty3 is an open-source tool freely available at http://www.ebi.ac.uk/dasty/ under the terms of the GNU General public license. Source and documentation can be found at http://code.google.com/p/dasty/. Contact: hhe@ebi.ac.uk PMID:21798964

  11. Physik gestern und heute Das Eiskalorimeter

    NASA Astrophysics Data System (ADS)

    Heering, P.

    2003-07-01

    Kalorimetrische Messungen gehören heute zum experimentellen Standardrepertoire im Bereich der Thermodynamik und der physikalischen Chemie. Das erste Gerät für derartige Messungen entwickelten Ende des 18. Jahrhunderts die französischen Wissenschaftler Antoine Laurent Lavoisier und Pierre Simon de Laplace.

  12. GHRSST-14 DAS-TAG Report

    NASA Technical Reports Server (NTRS)

    Armstrong, Edward; Piolle, Jean Francois

    2013-01-01

    The DAS-TAG provides the informatics and data management expertise in emerging information technologies for the GHRSST community. It provides expertise in data and metadata formats and standards, fosters improvements for GHRSST data curation, experiments with new data processing paradigms, and evaluates services and tools for data usage. It provides a forum for producer and distributor data management issues and coordination.

  13. Análise da cinemática interna das regiões HII gigantes e das galáxias HII

    NASA Astrophysics Data System (ADS)

    Plana, H.; Telles, E.; Maíz-Apellániz, J.

    2003-08-01

    Neste trabalho nós mostramos os primeiros resultados de um estudo sobre a cinemática das Regiões HII Gigantes (GHIIRs) em galáxias próximas. Essas regiões HII têm um diâmetro médio entre 100 pc e 1000 pc e uma taxa de formação estelar de 106 M¤ / ano sendo equivalente à observada em galáxias de tipo tardio correspondendo a uma taxa de formação estelar por unidade de volume uma ordem de magnitude maior que a observada em regiões HII normais. Usando espectros de fenda longas em várias posições, nós construímos mapas de velocidades, de dispersão e de intensidade para várias linhas de emissão como Ha, Hb, [NII]6584 Å, [OIII]5007 Å e o doublet de [SII], para cinco regiões gigantes: NGC 2403 II e IV, NGC 595, NGC 5461, NGC 5471, NGC 5455. O estudo da cinemática (mapas de velocidades e da dispersão) mostrou, por exemplo, a presença de cascas em expansão em NGC 595 ou perfis de emissão com várias componentes em NGC 5461. Os perfis de emissão também mostram velocidades supersônicas. Os resultados são discutidos em comparação com os de estudos anteriores realizados.

  14. PoroTomo Project - Subatask 6.2: Deploy and Operate DAS and DTS arrays - DAS Earthquake Data

    SciTech Connect

    Kurt Feigl

    2016-03-21

    The submitted data correspond to the vibration caused by a 3.4 M earthquake and captured by the DAS horizontal and vertical arrays during the PoroTomo Experiment. Earthquake information : M 4.3 - 23km ESE of Hawthorne, Nevada Time: 2016-03-21 07:37:10 (UTC) Location: 38.479°N 118.366°W Depth: 9.9 km Files for horizontal DAS array (each file is 30 s long and contain 8700 channels): PoroTomo_iDAS16043_160321073721.sgy PoroTomo_iDAS16043_160321073751.sgy Files for vertical DAS Array (each file is 30 s long and contain 380 channels): PoroTomo_iDAS025_160321073717.sgy PoroTomo_iDAS025_160321073747.sgy

  15. "Das Konkrete ist das Abstrakte, an das man sich schließlich gewöhnt hat." (Laurent Schwartz) Über den Ablauf des mathematischen Verstehens

    NASA Astrophysics Data System (ADS)

    Lowsky, Martin

    Die im Titel genannte Aussage findet sich in den Lebenserinnerungen von Laurent Schwartz (1915-2002), einem der fruchtbarsten Mathematiker, Mitglied der Gruppe Bourbaki. Im Original lautet die Aussage: "un objet concret est un objet abstrait auquel on a fini par s'habituer." Schwartz erläutert sie am Beispiel des Integrals über {e^{-1/2{x^2}}} , das den Wert Wurzel aus 2π hat und in dem sich also die Zahlen e und π verknüpfen. Was Schwartz aber vor allem ausdrücken will, ist dies: Das mathematische Verständnisd geht langsam vor sich und es bedarf der Anstrengung. "Es ist eine Frage der Zeit und der Energie", sagt Schwartz, und gerade dies mache es so schwer, die höhere Mathematik unter das Volk zu bringen. Das Lernen und Lehren von Mathematik laufe eben mühevoll und langsam ab.

  16. Pedagogical Basis of DAS Formalism in Engineering Education

    ERIC Educational Resources Information Center

    Hiltunen, J.; Heikkinen, E.-P.; Jaako, J.; Ahola, J.

    2011-01-01

    The paper presents a new approach for a bachelor-level curriculum structure in engineering. The approach is called DAS formalism according to its three phases: description, analysis and synthesis. Although developed specifically for process and environmental engineering, DAS formalism has a generic nature and it could also be used in other…

  17. Evidence of Motor Programming Deficits in Children Diagnosed with DAS.

    ERIC Educational Resources Information Center

    Nijland, Lian; Maassen, Ben; van der Meulen, Sjoeke

    2003-01-01

    Five children with developmental apraxia of speech (DAS), 5 controls (ages 5-6), and 6 adults produced utterances in a normal condition and in a bite-block condition in which the mandible was in a fixed position. In children with DAS, the bite-block had large effects on coarticulatory patterns and vowel quality. (Contains references.) (Author/CR)

  18. Twenty‐eight‐joint counts invalidate the DAS28 remission definition owing to the omission of the lower extremity joints: a comparison with the original DAS remission

    PubMed Central

    Landewé, R; van der Heijde, D; van der Linden, S; Boers, M

    2006-01-01

    Objective To compare 28 joint disease activity score (DAS28) remission with comprehensive joint count DAS remission in rheumatoid arthritis. Methods 620 actually measured paired observations of DAS28 and DAS were analysed in 155 patients. Discordant observations (either DAS or DAS28 below remission cut off level: 1.6 for DAS and 2.6 for DAS28) and concordant observations (both DAS and DAS28 below their remission cut off level) were analysed separately. Results 91 of 620 paired DAS observations (15%) were discordant; 87 (in 53 patients) comprised observations in which the DAS28 remission criterion, but not the DAS remission criterion, was met. The reverse was found in only four observations, which were therefore omitted. With the original DAS as standard, DAS28 sensitivity was 95% and specificity 84%. Probability plots showed a swollen joint count >0 in 75% of discordant pairs v 48% of concordant pairs. The same was found for total joint count (TJC >0 in 90% v 40%; median TJC, 0 v 6) and patient global assessment, but not for ESR. Individual joint analysis showed that 51% of discordant v 18% of concordant observations (p<0.0005) had involvement of lower extremity joints that are not included in the DAS28. Conclusions DAS remission is more conservative than DAS28 remission. Activity (tenderness and swelling) in joints not included in the reduced joint counts (ankles, feet) mainly account for the discrepancy between the two assessments. DAS28 remission at a cut off level of 2.6 has insufficient construct validity and should be used with caution in clinical practice and clinical trials. PMID:16219709

  19. DAS: A Data Management System for Instrument Tests and Operations

    NASA Astrophysics Data System (ADS)

    Frailis, M.; Sartor, S.; Zacchei, A.; Lodi, M.; Cirami, R.; Pasian, F.; Trifoglio, M.; Bulgarelli, A.; Gianotti, F.; Franceschi, E.; Nicastro, L.; Conforti, V.; Zoli, A.; Smart, R.; Morbidelli, R.; Dadina, M.

    2014-05-01

    The Data Access System (DAS) is a and data management software system, providing a reusable solution for the storage of data acquired both from telescopes and auxiliary data sources during the instrument development phases and operations. It is part of the Customizable Instrument WorkStation system (CIWS-FW), a framework for the storage, processing and quick-look at the data acquired from scientific instruments. The DAS provides a data access layer mainly targeted to software applications: quick-look displays, pre-processing pipelines and scientific workflows. It is logically organized in three main components: an intuitive and compact Data Definition Language (DAS DDL) in XML format, aimed for user-defined data types; an Application Programming Interface (DAS API), automatically adding classes and methods supporting the DDL data types, and providing an object-oriented query language; a data management component, which maps the metadata of the DDL data types in a relational Data Base Management System (DBMS), and stores the data in a shared (network) file system. With the DAS DDL, developers define the data model for a particular project, specifying for each data type the metadata attributes, the data format and layout (if applicable), and named references to related or aggregated data types. Together with the DDL user-defined data types, the DAS API acts as the only interface to store, query and retrieve the metadata and data in the DAS system, providing both an abstract interface and a data model specific one in C, C++ and Python. The mapping of metadata in the back-end database is automatic and supports several relational DBMSs, including MySQL, Oracle and PostgreSQL.

  20. Pedagogical basis of DAS formalism in engineering education

    NASA Astrophysics Data System (ADS)

    Hiltunen, J.; Heikkinen, E.-P.; Jaako, J.; Ahola, J.

    2011-03-01

    The paper presents a new approach for a bachelor-level curriculum structure in engineering. The approach is called DAS formalism according to its three phases: description, analysis and synthesis. Although developed specifically for process and environmental engineering, DAS formalism has a generic nature and it could also be used in other engineering fields. The motivation for this new curriculum structure originates from the urge to solve the problems that engineering education has faced during the past decades, e.g. student recruitment problems and dissatisfactory learning outcomes. The focus of this paper is on the structure of the curriculum but the content is also discussed when it has an effect on the structure and its implementation. The presented structure, i.e. DAS formalism, builds upon the ideas of some classical pedagogical theories, which have regularly been applied at course level but seldom used to solve curriculum-level issues.

  1. The development of the disease activity score (DAS) and the disease activity score using 28 joint counts (DAS28).

    PubMed

    van Riel, P L C M

    2014-01-01

    In rheumatoid arthritis, disease activity cannot be measured using a single variable. The Disease Activity Score (DAS) has been developed as a quantitative index to be able to measure, study and manage disease activity in RA in daily clinical practice, clinical trials, and long term observational studies. The DAS is a continuous measure of RA disease activity that combines information from swollen joints, tender joints, acute phase response and patient self-report of general health. Cut points were developed to classify patients in remission, as well as low, moderate, and severe disease activity in the 1990s. DAS-based EULAR response criteria were primarily developed to be used in clinical trials to classify individual patients as non-, moderate, or good responders, depending on the magnitude of change and absolute level of disease activity at the conclusion of the test.

  2. On the Law of Inertia. Translation of: Ueber das Beharrungsgesetz

    NASA Astrophysics Data System (ADS)

    Lange, Ludwig

    2014-04-01

    This article is a translation of Ludwig Lange: "Ueber das Beharrungsgesetz" in: Berichte ueber Verhandlungen der Koenigl. Saechsischen Gesellschaft der Wissenschaften, math.-physik. Klasse (Leipzig, 1885), SS. 333-351. Translated by Herbert Pfister, Institut für Theoretische Physik, Universität Tübingen, Auf der Morgenstelle 14, 72076 Tübingen, Germany; herbert.pfister@uni-tuebingen.de. Kind assistance by Julian Barbour is acknowledged.

  3. Statistical Quality Control of Moisture Data in GEOS DAS

    NASA Technical Reports Server (NTRS)

    Dee, D. P.; Rukhovets, L.; Todling, R.

    1999-01-01

    A new statistical quality control algorithm was recently implemented in the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The final step in the algorithm consists of an adaptive buddy check that either accepts or rejects outlier observations based on a local statistical analysis of nearby data. A basic assumption in any such test is that the observed field is spatially coherent, in the sense that nearby data can be expected to confirm each other. However, the buddy check resulted in excessive rejection of moisture data, especially during the Northern Hemisphere summer. The analysis moisture variable in GEOS DAS is water vapor mixing ratio. Observational evidence shows that the distribution of mixing ratio errors is far from normal. Furthermore, spatial correlations among mixing ratio errors are highly anisotropic and difficult to identify. Both factors contribute to the poor performance of the statistical quality control algorithm. To alleviate the problem, we applied the buddy check to relative humidity data instead. This variable explicitly depends on temperature and therefore exhibits a much greater spatial coherence. As a result, reject rates of moisture data are much more reasonable and homogeneous in time and space.

  4. M-DAS: System for multispectral data analysis. [in Saginaw Bay, Michigan

    NASA Technical Reports Server (NTRS)

    Johnson, R. H.

    1975-01-01

    M-DAS is a ground data processing system designed for analysis of multispectral data. M-DAS operates on multispectral data from LANDSAT, S-192, M2S and other sources in CCT form. Interactive training by operator-investigators using a variable cursor on a color display was used to derive optimum processing coefficients and data on cluster separability. An advanced multivariate normal-maximum likelihood processing algorithm was used to produce output in various formats: color-coded film images, geometrically corrected map overlays, moving displays of scene sections, coverage tabulations and categorized CCTs. The analysis procedure for M-DAS involves three phases: (1) screening and training, (2) analysis of training data to compute performance predictions and processing coefficients, and (3) processing of multichannel input data into categorized results. Typical M-DAS applications involve iteration between each of these phases. A series of photographs of the M-DAS display are used to illustrate M-DAS operation.

  5. The Disease Activity Score (DAS) and the Disease Activity Score using 28 joint counts (DAS28) in the management of rheumatoid arthritis.

    PubMed

    van Riel, Piet L C M; Renskers, Lisanne

    2016-01-01

    In rheumatoid arthritis (RA), disease activity cannot be measured in all individual patients according to a single variable. The Disease Activity Score (DAS) and the DAS28 have been developed to measure disease activity in RA both in daily clinical practice as well as in clinical trials on a group as well as individual level. The DAS/DAS28 is a continuous measure of RA disease activity that combines information from swollen joints, tender joints, acute phase response and general health. The DAS-based EULAR response criteria were primarily developed to be used in clinical trials. The EULAR response criteria classify individual patients as non-, moderate, or good responders, dependent on the magnitude of change and level of disease activity reached. In addition, already in the early nineties, cut points were developed to categorise patients in remission. The DAS28 is incorporated in several electronic patient records and web-based systems for monitoring purposes in daily clinical practice. In addition to this, it is being used in combination with patient-reported outcome measures (PROMs) to facilitate self-monitoring.

  6. [Prevalence of use of preimplantation genetic diagnosis in Unidade Clínica de Paramiloidose from Centro Hospitalar do Porto].

    PubMed

    Valdrez, Kátia; Alves, Elisabete; Coelho, Teresa; Silva, Susana

    2014-01-01

    IntroduçÉo: A Polineuropatia Amiloidótica Familiar, cujo maior foco mundial é em Portugal, é reconhecida pelo Conselho Nacional de ProcriaçÉo Medicamente Assistida como uma doença grave elegível para Diagnóstico Genético Pré-ImplantaçÉo. Pretendemos determinar a prevalência do uso de Diagnóstico Genético Pré-ImplantaçÉo nos portadores de Polineuropatia Amiloidótica Familiar seguidos na Unidade Clínica de Paramiloidose, Centro Hospitalar do Porto, e identificar os fatores associados.Material e Métodos: Entre janeiro e maio de 2013, recrutamos sistematicamente uma amostra representativa de portadores entre os 18 e 55 anos. A análise baseia-se em 111 portadores com diagnóstico familiar prévio da doença, que referiram estar envolvidos numa tentativa de gravidez alguma vez depois de 2001. Através de questionário autoadministrado, recolhemos dados sociodemográficos e informações sobre o uso de Diagnóstico Genético Pré-ImplantaçÉo. Para comparaçÉo de proporções, utilizamos o teste de qui-quadrado. Odds ratios brutos e ajustados e os respetivos intervalos de confiança de 95% (IC 95%) foram estimados através de regressÉo logística multivariada.Resultados: A prevalência de uso de Diagnóstico Genético Pré-ImplantaçÉo foi de 20,7% (IC 95%: 13,6-29,5). Após ajuste, o rendimento familiar superior a 1000 '¬/mês (OR = 11,87; IC 95% 2,87-49,15) associou-se diretamente ao uso Diagnóstico Genético Pré-ImplantaçÉo, enquanto portadores com diagnóstico individual (OR = 0,15; IC 95% 0,04-0,57) e filhos nascidos após 2001 (OR = 0,07; IC 95% 0,02-0,32) revelaram uma prevalência de uso significativamente menor do que aqueles com diagnóstico individual e filhos nascidos antes de 2001.DiscussÉo: A baixa prevalência de uso de Diagnóstico Genético Pré-ImplantaçÉo, bem como a utilizaçÉo menos frequente da técnica por aqueles com um rendimento familiar mais baixo evidenciam a import'ncia de melhorar a acessibilidade ao Diagn

  7. Detecting Changes Following the Provision of Assistive Devices: Utility of the WHO-DAS II

    ERIC Educational Resources Information Center

    Raggi, Alberto

    2010-01-01

    The World Health Organization Disability Assessment Schedule II (WHO-DAS II) is a non-disease-specific International Classification of Functioning, Disability, and Health-based disability assessment instrument developed to measure activity limitations and restrictions to participation. The aim of this pilot study is to evaluate WHO-DAS II…

  8. Psychometric Properties of the Disability Assessment Schedule (DAS) for Behavior Problems: An Independent Investigation

    ERIC Educational Resources Information Center

    Tsakanikos, Elias; Underwood, Lisa; Sturmey, Peter; Bouras, Nick; McCarthy, Jane

    2011-01-01

    The present study employed the Disability Assessment Schedule (DAS) to assess problem behaviors in a large sample of adults with ID (N = 568) and evaluate the psychometric properties of this instrument. Although the DAS problem behaviors were found to be internally consistent (Cronbach's [alpha] = 0.87), item analysis revealed one weak item…

  9. DasR positively controls monensin production at two-level regulation in Streptomyces cinnamonensis.

    PubMed

    Zhang, Yue; Lin, Chun-Yan; Li, Xiao-Mei; Tang, Zheng-Kun; Qiao, Jianjun; Zhao, Guang-Rong

    2016-12-01

    The polyether ionophore antibiotic monensin is produced by Streptomyces cinnamonensis and is used as a coccidiostat for chickens and growth-promoting agent for cattle. Monensin biosynthetic gene cluster has been cloned and partially characterized. The GntR-family transcription factor DasR regulates antibiotic production and morphological development in Streptomyces coelicolor and Saccharopolyspora erythraea. In this study, we identified and characterized the two-level regulatory cascade of DasR to monensin production in S. cinnamonensis. Forward and reverse genetics by overexpression and antisense RNA silence of dasR revealed that DasR positively controls monensin production under nutrient-rich condition. Electrophoresis mobility shift assay (EMSA) showed that DasR protein specifically binds to the promoter regions of both pathway-specific regulatory gene monRII and biosynthetic genes monAIX, monE and monT. Semi-quantitative RT-PCR further confirmed that DasR upregulates the transcriptional levels of these genes during monensin fermentation. Subsequently, co-overexpressed dasR with pathway-specific regulatory genes monRI, monRII or monH greatly improved monensin production.

  10. Compositional safety of herbicide-tolerant DAS-81910-7 cotton.

    PubMed

    Herman, Rod A; Fast, Brandon J; Johnson, Tempest Y; Sabbatini, Jane; Rudgers, Gary W

    2013-11-27

    DAS-81910-7 cotton is a transgenic event that was transformed to contain the aad-12 and pat genes. These genes code for the AAD-12 and PAT proteins, which confer tolerance to the herbicides 2,4-D and glufosinate, respectively. Crop composition studies were conducted with DAS-81910-7 cotton (both nonsprayed and sprayed with 2,4-D and glufosinate) to comply with requirements of regulatory authorities responsible for evaluating crop safety. Results indicate compositional equivalence between DAS-81910-7 cottonseed and nontransgenic cottonseed and between sprayed and nonsprayed DAS-81910-7 cottonseed. This study builds on the results from many prior studies which support the conclusion that transgenesis is less likely to unexpectedly alter the composition of crops as compared with traditional breeding.

  11. Development of a Driver Alert System (DAS) for the Bradley Fighting Vehicle

    DTIC Science & Technology

    1988-07-01

    FIGHTING VEHICLE The survivability of a Bradley Fighting Vehicle (BFV) depends, in large part, on rapid response and movement in changing battle conditions...ARI Research Note 88-73 I6 0 Development of aDriver AertSystem CO (DAS) for the Bradley Fighting Vehicle * David F. Champion, Paul R. Roberson, and...System (DAS) Final Report for the Bradley Fighting Vehicle September 85 - September 87 6. PERFORMING ORG. REPORT NUMBER 7. AUTHOR(s) 6. CONTRACT OR GRANT

  12. Phase 1 Clinical Trials of DAS181, an Inhaled Sialidase, in Healthy Adults

    PubMed Central

    Zenilman, Jonathan M.; Fuchs, Edward J.; Hendrix, Craig W.; Radebaugh, Christine; Jurao, Robert; Nayak, Seema U.; Hamilton, Robert G.; Griffiss, J. McLeod

    2015-01-01

    DAS181, (study drug, Fludase®) was developed for treatment of influenza and parainfluenza infections. Delivered by inhalation, DAS181 cleaves sialic acid receptors from respiratory epithelial cells. Treatment of influenza for three days with DAS181 reduced viral shedding. To increase deposition in the upper airways and decrease systemic absorption, the particle size was increased to 10 microns. We conducted two Phase I trials with three cohorts, randomized 2:1, active drug to placebo. The initial cohort got a single 20 mg dose of DAS181, or placebo; the second, 20 mg DAS181 or placebo for 10 days, and the third got 20 mg of DAS181or placebo for 3 days. Formulations differed slightly in their excipients. Subjects in the 1- and 3-day cohorts completed dosing without serious adverse events. Two subjects in the 10-day cohort stopped at Day 9 after developing respiratory and systemic symptoms, and a third experienced a decrease in FEV1 (Forced Expiratory Volume in 1 second) after the 9th dose and a further decline after the 10th dose. Plasma DAS181, in the 10-day cohort, peaked and began falling before the last dose. Antibodies, predominately IgG with neutralizing activity, were detected in 15/18 subjects by Day 30. The highest IgG concentrations were in the 10-day cohort. The respiratory adverse events occurring after seven days and rapid drug clearance during continued dosing are consistent with the induction of DAS181 antibodies. This could preclude use of this medication for longer than seven days or for repeated courses. (These studies have been registered at ClinicalTrials.gov under registration nos. NCT 00527865 and NCT 01651494.) PMID:26391974

  13. Phase 1 clinical trials of DAS181, an inhaled sialidase, in healthy adults.

    PubMed

    Zenilman, Jonathan M; Fuchs, Edward J; Hendrix, Craig W; Radebaugh, Christine; Jurao, Robert; Nayak, Seema U; Hamilton, Robert G; McLeod Griffiss, J

    2015-11-01

    DAS181, (study drug, Fludase®) was developed for treatment of influenza and parainfluenza infections. Delivered by inhalation, DAS181 cleaves sialic acid receptors from respiratory epithelial cells. Treatment of influenza for three days with DAS181 reduced viral shedding. To increase deposition in the upper airways and decrease systemic absorption, the particle size was increased to 10μm. We conducted two Phase I trials with three cohorts, randomized 2:1, active drug to placebo. The initial cohort got a single 20mg dose of DAS181, or placebo; the second, 20mg DAS181 or placebo for 10days, and the third got 20mg of DAS181 or placebo for 3days. Formulations differed slightly in their excipients. Subjects in the 1- and 3-day cohorts completed dosing without serious adverse events. Two subjects in the 10-day cohort stopped at Day 9 after developing respiratory and systemic symptoms, and a third experienced a decrease in FEV1 (Forced Expiratory Volume in 1s) after the 9th dose and a further decline after the 10th dose. Plasma DAS181, in the 10-day cohort, peaked and began falling before the last dose. Antibodies, predominately IgG with neutralizing activity, were detected in 15/18 subjects by Day 30. The highest IgG concentrations were in the 10-day cohort. The respiratory adverse events occurring after seven days and rapid drug clearance during continued dosing are consistent with the induction of DAS181 antibodies. This could preclude use of this medication for longer than seven days or for repeated courses. (These studies have been registered at ClinicalTrials.gov under registration Nos. NCT 00527865 and NCT 01651494.).

  14. VIIRS ocean color data visualization and processing with IDL-based NOAA-SeaDAS

    NASA Astrophysics Data System (ADS)

    Wang, Xiaolong; Liu, Xiaoming; Jiang, Lide; Wang, Menghua; Sun, Junqiang

    2014-11-01

    The NOAA Sea-viewing Data Analysis System (NOAA-SeaDAS) is an Interactive Data Language (IDL)-based satellite data visualization, analysis, and processing system based on the version 6.4 of the NASA's Sea-viewing Wide Field-ofview (SeaWiFS) Data Analysis System (SeaDAS) released in 2012. NOAA-SeaDAS inherited all the original functionalities of SeaDAS 6.4 and was upgraded with many new functions and new sensor supports, particularly the support of the Visible Infrared Imaging Radiometer Suite (VIIRS) onboard the Suomi National Polar-Orbiting Partnership (SNPP). The main goal of the NOAA-SeaDAS development is primarily in support of NOAA ocean color team's calibration and validation activities. The current version of NOAA-SeaDAS can visualize, analyze, and process VIIRS Sensor Data Records (SDR or Level-1B data) produced by the NOAA Interface Data Processing System (IDPS), ocean color Environmental Data Records (EDR or Level-2 data) produced by the NOAA Multi-Sensor Level-1 to Level- 2 (MSL12) ocean color data processing system, and Level-3 data binned or mapped from Level-2 data produced by NOAA-MSL12. NOAA-SeaDAS is currently serving an active IDL user group at NOAA and will serve other institutions and universities in the future. The goal is to allow various scientific users to visualize, analyze, and process VIIRS data from Level-1B through Level-2 and Level-3. In addition, NOAA-SeaDAS can also visualize satellite images from the Korean Geostationary Ocean Color Imager (GOCI), as well as many other satellite ocean color sensors, e.g., SeaWiFS, the Moderate Resolution Imaging Spectroradiometer (MODIS), etc. NOAA-SeaDAS is under constant development to create new system functionalities and enhance user experience. With constantly increasing volume in the global ocean color data archive, NOAA-SeaDAS will play an important role in support of global marine environment data analysis and various scientific applications.

  15. Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein.

    PubMed

    Triana-Baltzer, Gallen B; Gubareva, Larisa V; Klimov, Alexander I; Wurtman, David F; Moss, Ronald B; Hedlund, Maria; Larson, Jeffrey L; Belshe, Robert B; Fang, Fang

    2009-11-06

    Antiviral drug resistance for influenza therapies remains a concern due to the high prevalence of H1N1 2009 seasonal influenza isolates which display H274Y associated oseltamivir-resistance. Furthermore, the emergence of novel H1N1 raises the potential that additional reassortments can occur, resulting in drug resistant virus. Thus, additional antiviral approaches are urgently needed. DAS181 (Fludase), a sialidase fusion protein, has been shown to have inhibitory activity against a large number of seasonal influenza strains and a highly pathogenic avian influenza (HPAI) strain (H5N1). Here, we examine the in vitro activity of DAS181 against a panel of 2009 oseltamivir-resistant seasonal H1N1 clinical isolates. The activity of DAS181 against nine 2009, two 2007, and two 2004 clinical isolates of seasonal IFV H1N1 was examined using plaque number reduction assay on MDCK cells. DAS181 strongly inhibited all tested isolates. EC50 values remained constant against isolates from 2004, 2007, and 2009, suggesting that there was no change in DAS181 sensitivity over time. As expected, all 2007 and 2009 isolates were resistant to oseltamivir, consistent with the identification of the H274Y mutation in the NA gene of all these isolates. Interestingly, several of the 2007 and 2009 isolates also exhibited reduced sensitivity to zanamivir, and accompanying HA mutations near the sialic acid binding site were observed. DAS181 inhibits IFV that is resistant to NAIs. Thus, DAS181 may offer an alternative therapeutic option for seasonal or pandemic IFVs that become resistant to currently available antiviral drugs.

  16. BOOK REVIEW: Geheimnisvolles Universum - Europas Astronomen entschleiern das Weltall

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Lorenzen, D. H.

    2002-12-01

    The 25th birthday of ESO, in 1987, was celebrated by the publication of an illustrated popular book, "Exploring the Southern Sky" (Springer-Verlag 1987), which also saw editions in Danish, English, French, German, and Spanish. Written and illustrated by the ESO staff members Svend Laustsen, Claus Madsen and Richard M. West, its many pictures were mainly taken with the ESO 3.6m and Schmidt telescopes. The structure of the book - perhaps at that time somewhat unusual - started with things far away (Universe and galaxies), zoomed in to the Milky Way, and finally reached the Solar System (with a concluding chapter dealing with the La Silla observatory). Now, with the 4 units of the Very Large Telescope in full operation, and on the occasion of ESO's 40th birthday, another jubilee book has appeared: "Geheimnisvolles Universum: Europas Astronomen entschleiern das Weltall", written by the science journalist Dirk H. Lorenzen, of Hamburg, Germany, and prefaced by Catherine Cesarsky, Director General of ESO. Presumably, this book will also soon become available in more languages spoken in ESO member countries. Thus it may be worthwhile to review the first edition, although some readers may like to wait for more easily accessible editions. Before going into details, let me first mention that I find this a very impressing book, great to look at and refreshing to read. With ESO seen through the eyes of a visitor, things gain a perspective that is quite different from that of the previous book, and at least as attractive. It comes as no surprise that the book starts with a visit of ESO's showcase, the Paranal Observatory, and the writer not only notes down his own impressions, but also cites statements of some of the many people that keep Paranal going - technicians and staff astronomers. This mixture of texts provides a good impression of the operations at a large observatory for the general reader. The two more 'astronomical' parts that follow deal with star and planet

  17. Amerikas Einschätzung der deutschen Atomforschung: Das deutsche Uranprojekt

    NASA Astrophysics Data System (ADS)

    Walker, Mark

    2002-07-01

    Die amerikanischen Wissenschaftler und ihre emigrierten Kollegen, die am Bau der Atombombe beteiligt waren, verfügten über sehr widersprüchliche und großteils falsche Informationen über den Fortschritt des deutschen Uranprogramms. Noch nach Kriegsende lässt sich dies an Aussagen des Leiters der amerikanischen Alsos-Mission, Samuel Goudsmit, festmachen. Tatsächlich war das deutsche Programm hinsichtlich seiner wissenschaftlichen Grundlagen und des Managements nicht so unterlegen, wie vielfach behauptet wurde. Aber die deutschen Behörden waren nicht in der Lage, Geld und Ressourcen in gleichem Maße in das Uranprojekt zu investieren, wie etwa in das Peenemünder Raketenprojekt.

  18. The Deaf Acculturation Scale (DAS): Development and Validation of a 58-Item Measure

    PubMed Central

    Maxwell-McCaw, Deborah; Zea, Maria Cecilia

    2011-01-01

    This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales, and construct validity was established by demonstrating that the DAS could discriminate groups based on parental hearing status, school background, and use of self-labels. Construct validity was further demonstrated through factorial analyses, and findings resulted in a final 58-item measure. Directions for future research are discussed. PMID:21263041

  19. Psychometric properties of the Death Anxiety Scale (DAS) among terminally ill cancer patients.

    PubMed

    Royal, Kenneth D; Elahi, Fereshte

    2011-01-01

    Research conducted with the terminally ill population in relation to death anxiety is rare and mostly outdated. The purpose of this study was to evaluate the psychometric properties of the widely used Death Anxiety Scale (DAS) on a sample of terminal cancer patients.Additionally, validation studies of the DAS have exclusively used traditional statistical methods for analysis. The current study utilized an item response theory technique (IRT), namely the Rasch Rating Scale model for data analysis. The methodology employed may be useful for other researchers conducting validation studies from an IRT perspective.

  20. Anbindung des SISIS-SunRise-Bibliothekssystems an das zentrale Identitätsmanagement

    NASA Astrophysics Data System (ADS)

    Ebner, Ralf; Pretz, Edwin

    Wir berichten über Konzepte und Implementierungen zur Datenprovisionierung aus den Personenverwaltungssystemen der Technischen Universität München (TUM) über das zentrale Metadirectory am Leibniz-Rechenzentrum (LRZ) in das SISIS-SunRise-Bibliothekssystem der Universitätsbibliothek der TUM (TUB). Es werden drei Implementierungsvarianten diskutiert, angefangen von der Generierung und Übertragung einfacher CSV-Dateien über ein OpenLDAP-basiertes Konzept als Backend für die SISIS-Datenbank bis zur endgültigen Implementierung mit dem OCLC IDM Connector.

  1. The Deaf Acculturation Scale (DAS): development and validation of a 58-item measure.

    PubMed

    Maxwell-McCaw, Deborah; Zea, Maria Cecilia

    2011-01-01

    This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales, and construct validity was established by demonstrating that the DAS could discriminate groups based on parental hearing status, school background, and use of self-labels. Construct validity was further demonstrated through factorial analyses, and findings resulted in a final 58-item measure. Directions for future research are discussed.

  2. The Great War and Remembrance in Jose Leon Machado's "Memoria das Estrelas sem Brilho"

    ERIC Educational Resources Information Center

    Azevedo, Milton M.

    2011-01-01

    This article analyzes Jose Leon Machado's novel, "Memoria das Estrelas sem Brilho," as a multilayered historical novel in which a war story provides a background for comments on aspects of early twentieth-century Portuguese society, such as male bonding, religion, sexual mores, and social stratification. (Contains 11 notes.)

  3. Incorporating Parallel Computing into the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Larson, Jay W.

    1998-01-01

    Atmospheric data assimilation is a method of combining actual observations with model forecasts to produce a more accurate description of the earth system than the observations or forecast alone can provide. The output of data assimilation, sometimes called the analysis, are regular, gridded datasets of observed and unobserved variables. Analysis plays a key role in numerical weather prediction and is becoming increasingly important for climate research. These applications, and the need for timely validation of scientific enhancements to the data assimilation system pose computational demands that are best met by distributed parallel software. The mission of the NASA Data Assimilation Office (DAO) is to provide datasets for climate research and to support NASA satellite and aircraft missions. The system used to create these datasets is the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The core components of the the GEOS DAS are: the GEOS General Circulation Model (GCM), the Physical-space Statistical Analysis System (PSAS), the Observer, the on-line Quality Control (QC) system, the Coupler (which feeds analysis increments back to the GCM), and an I/O package for processing the large amounts of data the system produces (which will be described in another presentation in this session). The discussion will center on the following issues: the computational complexity for the whole GEOS DAS, assessment of the performance of the individual elements of GEOS DAS, and parallelization strategy for some of the components of the system.

  4. MiDAS: the field guide to the microbes of activated sludge

    PubMed Central

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads; Nierychlo, Marta; McIlroy, Bianca; Hansen, Aviaja Anna; Karst, Søren Michael; Nielsen, Jeppe Lund; Nielsen, Per Halkjær

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properties of some of these genera are described, but most are known only from sequence data. The MiDAS taxonomy is a manual curation of the SILVA taxonomy that proposes a name for all genus-level taxa observed to be abundant by large-scale 16 S rRNA gene amplicon sequencing of full-scale activated sludge communities. The taxonomy can be used to classify unknown sequences, and the online MiDAS field guide links the identity to the available information about their morphology, diversity, physiology and distribution. The use of a common taxonomy across the field will provide a solid foundation for the study of microbial ecology of the activated sludge process and related treatment processes. The online MiDAS field guide is a collaborative workspace intended to facilitate a better understanding of the ecology of activated sludge and related treatment processes—knowledge that will be an invaluable resource for the optimal design and operation of these systems. Database URL: http://www.midasfieldguide.org PMID:26120139

  5. The Deaf Acculturation Scale (DAS): Development and Validation of a 58-Item Measure

    ERIC Educational Resources Information Center

    Maxwell-McCaw, Deborah; Zea, Maria Cecilia

    2011-01-01

    This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales,…

  6. A Brief History of the J.P. Das Developmental Disabilities Centre

    ERIC Educational Resources Information Center

    Sobsey, Dick

    2008-01-01

    The J.P. Das Developmental Disabilities Centre celebrated its 40th anniversary on September 1, 2007, followed by The University of Alberta's 100th anniversary in 2008. The year 2008 also brought the appointment of a new Director for the Centre. As the immediate past Director of the Centre, the author recounts some of the history of the J.P. Das…

  7. PoroTomo Project - Subatask 6.2: Deploy and Operate DAS and DTS arrays

    SciTech Connect

    Dante Fratta

    2016-03-31

    This metadata submission includes the coordinates of the DAS and DTS surface and borehole arrays, the list of file names, and the list of recorded files during testing at the PoroTomo Natural Laboratory at Brady Hot Spring in Nevada. Testing was completed during March 2016.

  8. MiDAS: the field guide to the microbes of activated sludge.

    PubMed

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads; Nierychlo, Marta; McIlroy, Bianca; Hansen, Aviaja Anna; Karst, Søren Michael; Nielsen, Jeppe Lund; Nielsen, Per Halkjær

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properties of some of these genera are described, but most are known only from sequence data. The MiDAS taxonomy is a manual curation of the SILVA taxonomy that proposes a name for all genus-level taxa observed to be abundant by large-scale 16 S rRNA gene amplicon sequencing of full-scale activated sludge communities. The taxonomy can be used to classify unknown sequences, and the online MiDAS field guide links the identity to the available information about their morphology, diversity, physiology and distribution. The use of a common taxonomy across the field will provide a solid foundation for the study of microbial ecology of the activated sludge process and related treatment processes. The online MiDAS field guide is a collaborative workspace intended to facilitate a better understanding of the ecology of activated sludge and related treatment processes--knowledge that will be an invaluable resource for the optimal design and operation of these systems.

  9. Reisen im freien Fall - Teil 2: Das Zwillingsparadoxon aus dem Blickwinkel der ART

    NASA Astrophysics Data System (ADS)

    Sonne, Bernd; Weiß, Reinhard

    2013-07-01

    Nachdem wir uns mit den Prinzipien der ART und einigen Beispielen vertraut gemacht haben, kommen wir nun zur Berechnung des Zwillingsparadoxons aus Sicht des reisenden Zwillings. Dabei spielt das Äquivalenzprinzip eine große Rolle. Deshalb wird die Bewegungssituation noch einmal erläutert, diesmal aus Sicht von Katrin. Sie befindet sich in ihrem System S'in Ruhe. In ihrem System läuft die Zeit t'ab. Nach dem Start fühlt Katrin jedoch eine Kraft, die sie als Gravitationskraft interpretieren kann. Sie merkt es daran, dass sie in den Sitz gedrückt wird. Nach einiger Zeit werden die Triebwerke abgeschaltet, und das Raumschiff fliegt mit konstanter Geschwindigkeit weiter, Phase 2. Anschließend wird der Schub der Triebwerke solange umgekehrt, bis das Raumschiff irgendwo mit der Geschwindigkeit null am Umkehrpunkt U landet, Phase 3 (Abb. 15.1). Die Erde, auf der sich Michael befindet, bewegt sich mit x'(t') aus Sicht von Katrin im freien Fall von ihr weg, s. das Experiment mit dem steigenden Fahrstuhl in Abschn. 13.2.1.

  10. A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats

    PubMed Central

    2012-01-01

    Background The herbal preparation DAS-77, used for the treatment of various ailments in Nigeria, contains the milled bark of Mangifera indica L. and root of Carica papaya L. Toxicological assessment of the preparation was carried out in this study. Methods In the acute toxicity study, DAS-77 was administered to mice p.o. up to 20 g/kg in divided doses and i.p. at 250–3000 mg/kg. Mortality within 24 h was recorded. In the chronic toxicity study, rats were treated p.o. for 90 days at doses of 80, 400 (therapeutic dose, TD) and 2000 mg/kg. By 90 days, animals were sacrificed and blood samples collected for hematological and biochemical analysis. Organs were harvested for weight determination, antioxidants and histopathological assessments. Results DAS-77 did not produce any lethality administered p.o. up to 20 g/kg in divided doses but the i.p. LD50 was 1122.0 mg/kg. At TD, DAS-77 produced significant (p < 0.05) reductions in body weight, food intake and K+, and increases in ovary weight, neutrophils and HDL, which were reversible. Histopathological presentations were generally normal. Effects at the other doses were comparable to those at TD except for reversible increases in antioxidants in the liver, kidney and testes, and sperm abnormality, and reductions in liver enzymes, sperm motility and count. Conclusions Findings in this study revealed that DAS-77 is relatively safe with the potential for enhancing in vivo antioxidant activity. However, possibly reversible side-effects include electrolyte imbalance and sterility in males. PMID:22892317

  11. A Letter to the Parent(s) of a Child with Developmental Apraxia of Speech. Part IV: Treatment of DAS.

    ERIC Educational Resources Information Center

    Hall, Penelope K.

    2000-01-01

    One of a series of letters to parents of children with developmental apraxia of speech (DAS), this letter discusses the treatment of DAS including linguistic approaches, motor-programming approaches, a combination of linguistic and motor-programming approaches, and treatment approaches that include specific sensory and gestural cueing techniques.…

  12. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... catch limits (ACL), annual catch targets (ACT), DAS allocations, and individual fishing quotas (IFQ... limits (ACL), annual catch targets (ACT), DAS allocations, and individual fishing quotas (IFQ). (a... limited access scallop fishery shall be allocated 94.5 percent of the ACL specified in paragraph (a)(1)...

  13. DAS Boot!

    ERIC Educational Resources Information Center

    Chretien, Wendy

    2007-01-01

    The residential services group is lobbying to dump its aging hard-wired phone system because students don't use it. The town and campus public safety officials are demanding that their portable two-way radios operate well not only outdoors, but within campus buildings. Students are now expecting text messaging and WiFi service to work everywhere…

  14. Clinical potential of DAS181 for treatment of parainfluenza-3 infections in transplant recipients.

    PubMed

    Guzmán-Suarez, B B; Buckley, M W; Gilmore, E T; Vocca, E; Moss, R; Marty, F M; Sanders, R; Baden, L R; Wurtman, D; Issa, N C; Fang, F; Koo, S

    2012-08-01

    Parainfluenza virus (PIV) infections can cause serious respiratory infections and death in immunocompromised patients. No antiviral agents have proven efficacy against PIV, and therapy generally consists of supportive care. DAS181, a novel sialidase fusion protein that temporarily disables airway epithelial PIV receptors by enzymatic removal of sialic acid moieties, has been shown to inhibit infection with PIV strains in vitro and in an animal model. We describe here the clinical course of 2 immunocompromised patients with PIV-3 infection, one with a history of lung transplantation and the other neutropenic after autologous hematopoietic stem cell transplantation for multiple myeloma. Both patients had substantial clinical improvement in respiratory and systemic symptoms after a 5-day DAS181 treatment course, although the clinical improvement in the autologous stem cell transplantation patient also paralleled neutrophil engraftment.

  15. Annotation and visualization of endogenous retroviral sequences using the Distributed Annotation System (DAS) and eBioX

    PubMed Central

    Martínez Barrio, Álvaro; Lagercrantz, Erik; Sperber, Göran O; Blomberg, Jonas; Bongcam-Rudloff, Erik

    2009-01-01

    Background The Distributed Annotation System (DAS) is a widely used network protocol for sharing biological information. The distributed aspects of the protocol enable the use of various reference and annotation servers for connecting biological sequence data to pertinent annotations in order to depict an integrated view of the data for the final user. Results An annotation server has been devised to provide information about the endogenous retroviruses detected and annotated by a specialized in silico tool called RetroTector. We describe the procedure to implement the DAS 1.5 protocol commands necessary for constructing the DAS annotation server. We use our server to exemplify those steps. Data distribution is kept separated from visualization which is carried out by eBioX, an easy to use open source program incorporating multiple bioinformatics utilities. Some well characterized endogenous retroviruses are shown in two different DAS clients. A rapid analysis of areas free from retroviral insertions could be facilitated by our annotations. Conclusion The DAS protocol has shown to be advantageous in the distribution of endogenous retrovirus data. The distributed nature of the protocol is also found to aid in combining annotation and visualization along a genome in order to enhance the understanding of ERV contribution to its evolution. Reference and annotation servers are conjointly used by eBioX to provide visualization of ERV annotations as well as other data sources. Our DAS data source can be found in the central public DAS service repository, , or at . PMID:19534743

  16. 50 CFR 648.53 - Target total allowable catch, DAS allocations, and individual fishing quotas.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... additional DAS in proportion to the unharvested possession limit. For example, if a full-time vessel had an... calculate meat-weight, up to a maximum of 400 lb (181.4 kg) per trip. (B) Years active. For each eligible....125 5 1.25 (D) Contribution factor example. If a vessel landed 48,550 lb (22,022 kg) of scallops...

  17. Assimilation of SBUV Version 8 Radiances into the GEOS Ozone DAS

    NASA Technical Reports Server (NTRS)

    Mueller, Martin D.; Stajner, Ivanka; Bhartia, Pawan K.

    2004-01-01

    In operational weather forecasting, the assimilation of brightness temperatures from satellite sounders, instead of assimilation of 1D-retrievals has become increasingly common practice over the last two decades. Compared to these systems, assimilation of trace gases is still at a relatively early stage of development, and efforts to directly assimilate radiances instead of retrieved products have just begun a few years ago, partially because it requires much more computation power due to the employment of a radiative transport forward model (FM). This paper will focus on a method to assimilate SBUV/2 radiances (albedos) into the Global Earth Observation System Ozone Data Assimilation Scheme (GEOS-03DAS). While SBUV-type instruments cannot compete with newer sensors in terms of spectral and horizontal resolution, they feature a continuous data record back to 1978, which makes them very valuable for trend studies. Assimilation can help spreading their ground coverage over the whole globe, as has been previously demonstrated with the GEOS-03DAS using SBUV Version 6 ozone profiles. Now, the DAS has been updated to use the newly released SBUV Version 8 data. We will compare pre]lmlnarv results of SBUV radiance assimilation with the assimilation of retrieved ozone profiles, discuss methods to deal with the increased computational load, and try to assess the error characteristics and future potential of the new approach.

  18. pH modulates arsenic toxicity in Bacillus licheniformis DAS-2.

    PubMed

    Tripti, K; Shardendu

    2016-08-01

    The toxic characteristics of arsenic species, As(V) and As(III) result in ecological risks. Arsenic tolerant bacterium was isolated and identified as the Bacillus licheniformis DAS-2 through 16SrDNA sequencing. B. licheniformis DAS-2 was efficient to tolerate and remove both the As(V)[MIC 8mM] and As(III)[MIC 6mM] from the growth medium. The potential for the removal/uptake of arsenic from the 3, 5 and 7mM As(V) enriched growth media was 100%, 60% and 35% respectively and from the 1, 3 and 5mM As(III) enrichment it was 100%, 99% and 58% respectively at neutral pH. 80% of uptake As(V) was reduced to As(III) in 3mM As(V) enrichment which was gradually decreased to only 17% at 7mM As(V) enrichment at neutral pH. The arsenic toxicity in B. licheniformis DAS-2 was found modulated by pH and was examined through alteration in growth, uptake/removal, reduction and measurement of chemical toxicity.

  19. I/O Parallelization for the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Lucchesi, R.; Sawyer, W.; Takacs, L. L.; Lyster, P.; Zero, J.

    1999-01-01

    The National Aeronautics and Space Administration (NASA) Data Assimilation Office (DAO) at the Goddard Space Flight Center (GSFC) has developed the GEOS DAS, a data assimilation system that provides production support for NASA missions and will support NASA's Earth Observing System (EOS) in the coming years. The DAO's support of the EOS project along with the requirement of producing long-term reanalysis datasets with an unvarying system levy a large I/O burden on the future system. The DAO has been involved in prototyping parallel implementations of the GEOS DAS for a number of years and is now converting the production version from shared-memory parallelism to distributed-memory parallelism using the portable Message-Passing Interface (MPI). If the MPI-based GEOS DAS is to meet these production requirements, we must make I/O from the parallel system efficient. We have designed a scheme that allows efficient I/O processing while retaining portability, reducing the need for post-processing, and producing data formats that are required by our users, both internal and external. The first phase of the GEOS DAS Parallel I/O System (GPIOS) will expand upon the common method of gathering global data to a Single PE for output. Instead of using a PE also tasked with primary computation, a number of PEs will be dedicated to I/O and its related tasks. This allows the data transformations and formatting required prior to output to take place asynchronously with respect to the GEOS DAS assimilation cycle, improving performance and generating output data sets in a format convenient for our users. I/O PEs can be added as needed to handle larger data volumes or to meet user file specifications. We will show I/O performance results from a prototype MPI GCM integrated with GPIOS. Phase two of GPIOS development will examine ways of integrating new software technologies to further improve performance and build scalability into the system. The maturing of MPI-IO implementations and

  20. Validation of Land-Surface Mosaic Heterogeneity in the GEOS DAS

    NASA Technical Reports Server (NTRS)

    Bosilovich, Michael G.; Molod, Andrea; Houser, Paul R.; Schubert, Siegfried

    1999-01-01

    The Mosaic Land-surface Model (LSM) has been included into the current GEOS Data Assimilation System (DAS). The LSM uses a more advanced representation of physical processes than previous versions of the GEOS DAS, including the representation of sub-grid heterogeneity of the land-surface through the Mosaic approach. As a first approximation, Mosaic assumes that all similar surface types within a grid-cell can be lumped together as a single'tile'. Within one GCM grid-cell, there might be 1 - 5 different tiles or surface types. All tiles are subjected to the grid-scale forcing (radiation, air temperature and specific humidity, and precipitation), and the sub-grid variability is a function of the tile characteristics. In this paper, we validate the LSM sub-grid scale variability (tiles) using a variety of surface observing stations from the Southern Great Plains (SGP) site of the Atmospheric Radiation Measurement (ARM) Program. One of the primary goals of SGP ARM is to study the variability of atmospheric radiation within a G,CM grid-cell. Enough surface data has been collected by ARM to extend this goal to sub-grid variability of the land-surface energy and water budgets. The time period of this study is the Summer of 1998 (June I - September 1). The ARM site data consists of surface meteorology, energy flux (eddy correlation and bowen ratio), soil water observations spread over an area similar to the size of a G-CM grid-cell. Various ARM stations are described as wheat and alfalfa crops, pasture and range land. The LSM tiles considered at the grid-space (2 x 2.5) nearest the ARM site include, grassland, deciduous forests, bare soil and dwarf trees. Surface energy and water balances for each tile type are compared with observations. Furthermore, we will discuss the land-surface sub-grid variability of both the ARM observations and the DAS.

  1. High resolution DAS via sinusoidal frequency scan OFDR (SFS-OFDR).

    PubMed

    Leviatan, Eyal; Eyal, Avishay

    2015-12-28

    There are many advantages to using direct frequency modulation for OFDR based DAS. However, achieving sufficiently linear scan via direct frequency modulation is challenging and poses limits on the scan parameters. A novel method for analyzing sinusoidal frequency modulated light is presented and demonstrated for both static and dynamic sensing. SFS-OFDR projects the measured signal onto appropriate sinusoidal phase terms to obtain spatial information. Thus, by using SFS-OFDR on sinusoidal modulated light it is possible to make use of the many advantages offered by direct frequency modulation without the limitations posed by the linearity requirement.

  2. [An example of partnership cooperation. Cantonal League against Tuberculosis and Lung Diseases/Association "Das Band"].

    PubMed

    Michaelis, E

    1984-01-01

    Together with the Cantonal League against Tuberculosis and Lung Diseases of Zurich, the Association "Das Band" has organized a first course for parents of children with asthma. The course is a component of the associations new "Prophylaxis Program for Children with Asthma and Their Parents". By exchanging ideas, the parents should become able to reflect their situation, characterized by excessive protectionism, aggressiveness, and guiltiness, and they also should learn to accept the disease as a part of their daily life. The first course, which meanwhile is followed by a second one, provided a first base for the solution of the many problems.

  3. The development of Music in Dementia Assessment Scales (MiDAS).

    PubMed

    McDermott, Orii; Orrell, Martin; Ridder, Hanne Mette

    2015-07-03

    There is a need to develop an outcome measure specific to music therapy in dementia that reflects a holistic picture of the therapy process and outcome. This study aimed to develop a clinically relevant and scientifically robust music therapy outcome measure incorporating the values and views of people with dementia. Focus groups and interviews were conducted to obtain qualitative data on what music meant to people with dementia and the observed effects of music. Expert and peer consultations were conducted at each stage of the measure development to maximise its content validity. The new measure was field-tested by clinicians in a care home. Feedback from the clinicians and music therapy experts were incorporated during the review and refinement process of the measure. A review of the existing literature, the experiential results and the consensus process enabled the development of the new outcome measure "Music in Dementia Assessment Scales (MiDAS)". Analysis of the qualitative data identified five key areas of the impact of music on people with dementia and they were transformed as the five Visual Analogue Scale (VAS) items: levels of Interest, Response, Initiation, Involvement and Enjoyment. MiDAS comprises the five VAS items and a supplementary checklist of notable positive and negative reactions from the individual. This study demonstrates that it is possible to design and develop an easy to apply and rigorous quantitative outcome measure which has a high level of clinical relevance for people with dementia, care home staff and music therapists.

  4. Ocean Color Measurements from Landsat-8 OLI using SeaDAS

    NASA Technical Reports Server (NTRS)

    Franz, Bryan Alden; Bailey, Sean W.; Kuring, Norman; Werdell, P. Jeremy

    2014-01-01

    The Operational Land Imager (OLI) is a multi-spectral radiometer hosted on the recently launched Landsat-8 satellite. OLI includes a suite of relatively narrow spectral bands at 30-meter spatial resolution in the visible to shortwave infrared that make it a potential tool for ocean color radiometry: measurement of the reflected spectral radiance upwelling from beneath the ocean surface that carries information on the biogeochemical constituents of the upper ocean euphotic zone. To evaluate the potential of OLI to measure ocean color, processing support was implemented in SeaDAS, which is an open-source software package distributed by NASA for processing, analysis, and display of ocean remote sensing measurements from a variety of satellite-based multi-spectral radiometers. Here we describe the implementation of OLI processing capabilities within SeaDAS, including support for various methods of atmospheric correction to remove the effects of atmospheric scattering and absorption and retrieve the spectral remote-sensing reflectance (Rrs; sr exp 1). The quality of the retrieved Rrs imagery will be assessed, as will the derived water column constituents such as the concentration of the phytoplankton pigment chlorophyll a.

  5. A causa das estações do ano: modelos mentais

    NASA Astrophysics Data System (ADS)

    de Campos, J. A. S.; de Araujo, J. F. S.

    2003-08-01

    A década de 70 do século passado foi marcada pelo estudo das concepções alternativas que os alunos trazem para a sala de aula. A identificação destas concepções foi o ponto de partida para promover a mudança conceitual, onde as pré-concepções seriam trocadas pelas concepções científicas. Na década seguinte, surgiram muitas propostas de estratégias educacionais para facilitar esta troca, na sua maioria baseadas na idéia do conflito cognitivo, proposta por Piaget. Entretanto, os resultados pouco animadores conduziram à percepção de que a mudança conceitual é um processo mais complexo. Pelas idéias da Ciência Cognitiva, a mudança conceitual é uma mudança progressiva dos modelos mentais que o aluno tem sobre o mundo físico, através de enriquecimento e revisão. A causa das Estações do Ano é um tópico sobre o qual a maioria dos estudantes apresenta concepções alternativas. Os autores fizeram um levantamento sobre as pré-concepções encontradas em trabalhos sobre o tema (16 referências), procurando encontrar elementos comuns que indicassem a presença de modelos mentais específicos. As pré-concepções encontradas na literatura foram obtidas usando-se diversas metodologias (desde entrevistas clínicas até questionários de múltipla escolha) e envolvendo alunos e professores de diferentes regiões geográficas. A partir de uma análise aprofundada de cada trabalho, e utilizando-se a técnica das Redes Sistêmicas, chegou-se a conclusão que as diversas pré-concepções identificadas (em torno de 50), poderiam ser representadas por 6 modelos mentais, onde a explicação da causa das estações do ano tem um mecanismo causal responsável. Os mecanismos causais identificados foram: a dependência da distância, a dependência da orientação, a dependência conjunta da distância e orientação, a dependência da obstrução, a dependência da velocidade e a dependência da inclinação dos raios solares. Foram ainda identificadas

  6. Genome-wide analysis of in vivo binding of the master regulator DasR in Streptomyces coelicolor identifies novel non-canonical targets.

    PubMed

    Świątek-Połatyńska, Magdalena A; Bucca, Giselda; Laing, Emma; Gubbens, Jacob; Titgemeyer, Fritz; Smith, Colin P; Rigali, Sébastien; van Wezel, Gilles P

    2015-01-01

    Streptomycetes produce a wealth of natural products, including over half of all known antibiotics. It was previously demonstrated that N-acetylglucosamine and secondary metabolism are closely entwined in streptomycetes. Here we show that DNA recognition by the N-acetylglucosamine-responsive regulator DasR is growth-phase dependent, and that DasR can bind to sites in the S. coelicolor genome that have no obvious resemblance to previously identified DasR-responsive elements. Thus, the regulon of DasR extends well beyond what was previously predicted and includes a large number of genes with functions far removed from N-acetylglucosamine metabolism, such as genes for small RNAs and DNA transposases. Conversely, the DasR regulon during vegetative growth largely correlates to the presence of canonical DasR-responsive elements. The changes in DasR binding in vivo following N-acetylglucosamine induction were studied in detail and a possible molecular mechanism by which the influence of DasR is extended is discussed. Discussion of DasR binding was further informed by a parallel transcriptome analysis of the respective cultures. Evidence is provided that DasR binds directly to the promoters of all genes encoding pathway-specific regulators of antibiotic production in S. coelicolor, thereby providing an exquisitely simple link between nutritional control and secondary metabolism.

  7. Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene

    NASA Astrophysics Data System (ADS)

    Lee, Hyunah; Nam, Donggyu; Choi, Jae-Kyung; Araúzo-Bravo, Marcos J.; Kwon, Soon-Yong; Zaehres, Holm; Lee, Taehee; Park, Chan Young; Kang, Hyun-Wook; Schöler, Hans R.; Kim, Jeong Beom

    2016-02-01

    The maintenance of undifferentiated human pluripotent stem cells (hPSC) under xeno-free condition requires the use of human feeder cells or extracellular matrix (ECM) coating. However, human-derived sources may cause human pathogen contamination by viral or non-viral agents to the patients. Here we demonstrate feeder-free and xeno-free culture system for hPSC expansion using diffusion assisted synthesis-grown nanocrystalline graphene (DAS-NG), a synthetic non-biological nanomaterial which completely rule out the concern of human pathogen contamination. DAS-NG exhibited advanced biocompatibilities including surface nanoroughness, oxygen containing functional groups and hydrophilicity. hPSC cultured on DAS-NG could maintain pluripotency in vitro and in vivo, and especially cell adhesion-related gene expression profile was comparable to those of cultured on feeders, while hPSC cultured without DAS-NG differentiated spontaneously with high expression of somatic cell-enriched adhesion genes. This feeder-free and xeno-free culture method using DAS-NG will facilitate the generation of clinical-grade hPSC.

  8. Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene

    PubMed Central

    Lee, Hyunah; Nam, Donggyu; Choi, Jae-Kyung; Araúzo-Bravo, Marcos J.; Kwon, Soon-Yong; Zaehres, Holm; Lee, Taehee; Park, Chan Young; Kang, Hyun-Wook; Schöler, Hans R.; Kim, Jeong Beom

    2016-01-01

    The maintenance of undifferentiated human pluripotent stem cells (hPSC) under xeno-free condition requires the use of human feeder cells or extracellular matrix (ECM) coating. However, human-derived sources may cause human pathogen contamination by viral or non-viral agents to the patients. Here we demonstrate feeder-free and xeno-free culture system for hPSC expansion using diffusion assisted synthesis-grown nanocrystalline graphene (DAS-NG), a synthetic non-biological nanomaterial which completely rule out the concern of human pathogen contamination. DAS-NG exhibited advanced biocompatibilities including surface nanoroughness, oxygen containing functional groups and hydrophilicity. hPSC cultured on DAS-NG could maintain pluripotency in vitro and in vivo, and especially cell adhesion-related gene expression profile was comparable to those of cultured on feeders, while hPSC cultured without DAS-NG differentiated spontaneously with high expression of somatic cell-enriched adhesion genes. This feeder-free and xeno-free culture method using DAS-NG will facilitate the generation of clinical-grade hPSC. PMID:26846167

  9. Measuring Primary Teachers' Attitudes Toward Teaching Science: Development of the Dimensions of Attitude Toward Science (DAS) Instrument

    NASA Astrophysics Data System (ADS)

    van Aalderen-Smeets, Sandra; Walma van der Molen, Juliette

    2013-03-01

    In this article, we present a valid and reliable instrument which measures the attitude of in-service and pre-service primary teachers toward teaching science, called the Dimensions of Attitude Toward Science (DAS) Instrument. Attention to the attitudes of primary teachers toward teaching science is of fundamental importance to the professionalization of these teachers in the field of primary science education. With the development of this instrument, we sought to fulfill the need for a statistically and theoretically valid and reliable instrument to measure pre-service and in-service teachers' attitudes. The DAS Instrument is based on a comprehensive theoretical framework for attitude toward (teaching) science. After pilot testing, the DAS was revised and subsequently validated using a large group of respondents (pre-service and in-service primary teachers) (N = 556). The theoretical underpinning of the DAS combined with the statistical data indicate that the DAS possesses good construct validity and that it proves to be a promising instrument that can be utilized for research purposes, and also as a teacher training and coaching tool. This instrument can therefore make a valuable contribution to progress within the field of science education.

  10. Subchronic feeding study with genetically modified stacked trait lepidopteran and coleopteran resistant (DAS-Ø15Ø7-1xDAS-59122-7) maize grain in Sprague-Dawley rats.

    PubMed

    Appenzeller, Laura M; Malley, Linda; Mackenzie, Susan A; Hoban, Denise; Delaney, Bryan

    2009-07-01

    DAS-Ø15Ø7-1xDAS-59122-7 (1507x59122) is a genetically modified (GM) maize hybrid that was produced by crossing of two GM maize inbreds; DAS-Ø15Ø7-1 and DAS-59122-7. This hybrid cross expresses four transgenic proteins: Cry1F and PAT (from DAS-Ø15Ø7-1) and Cry34Ab1/Cry35Ab1 and PAT (from DAS-59122-7) that confer resistance to lepidopteran and coleopteran pests and tolerance to the herbicidal active ingredient glufosinate-ammonium. The current subchronic feeding study was conducted in Sprague-Dawley rats to evaluate the potential health effects of long-term consumption of a rodent diet containing 1507x59122 maize grain compared with a diet containing maize grain from its near-isogenic control (091). Diets formulated with three unrelated non-GM commercial hybrids (3573, 35P12, 36G12) were also included for within study reference data. All diets contained 34% (w/wt) maize grain and were prepared according to the specifications of PMI((R)) Nutrition International, LLC Certified Rodent LabDiet((R)) 5002 (PMI((R)) 5002). Diets were fed ad libitum to rats for at least 92days. OECD 408 response variables from rats fed the 1507x59122 diet were compared with those from rats fed the 091 control diet. No toxicologically significant differences were observed in nutritional performance variables, clinical and neurobehavioral signs, ophthalmology, clinical pathology (hematology, clinical chemistry, coagulation, and urinalysis), organ weights, and gross and microscopic pathology between rats in the 091 and 1507x59122 treatment groups. The results from this study demonstrate that 1507x59122 maize grain is as safe and nutritious as non-GM maize grain and support the concept that crossing of two safe GM maize events results in production of a safe stacked GM event.

  11. DasPy – Open Source Multivariate Land Data Assimilation Framework with High Performance Computing

    NASA Astrophysics Data System (ADS)

    Han, Xujun; Li, Xin; Montzka, Carsten; Kollet, Stefan; Vereecken, Harry; Hendricks Franssen, Harrie-Jan

    2015-04-01

    Data assimilation has become a popular method to integrate observations from multiple sources with land surface models to improve predictions of the water and energy cycles of the soil-vegetation-atmosphere continuum. In recent years, several land data assimilation systems have been developed in different research agencies. Because of the software availability or adaptability, these systems are not easy to apply for the purpose of multivariate land data assimilation research. Multivariate data assimilation refers to the simultaneous assimilation of observation data for multiple model state variables into a simulation model. Our main motivation was to develop an open source multivariate land data assimilation framework (DasPy) which is implemented using the Python script language mixed with C++ and Fortran language. This system has been evaluated in several soil moisture, L-band brightness temperature and land surface temperature assimilation studies. The implementation allows also parameter estimation (soil properties and/or leaf area index) on the basis of the joint state and parameter estimation approach. LETKF (Local Ensemble Transform Kalman Filter) is implemented as the main data assimilation algorithm, and uncertainties in the data assimilation can be represented by perturbed atmospheric forcings, perturbed soil and vegetation properties and model initial conditions. The CLM4.5 (Community Land Model) was integrated as the model operator. The CMEM (Community Microwave Emission Modelling Platform), COSMIC (COsmic-ray Soil Moisture Interaction Code) and the two source formulation were integrated as observation operators for assimilation of L-band passive microwave, cosmic-ray soil moisture probe and land surface temperature measurements, respectively. DasPy is parallelized using the hybrid MPI (Message Passing Interface) and OpenMP (Open Multi-Processing) techniques. All the input and output data flow is organized efficiently using the commonly used NetCDF file

  12. Viscous dissipation effects on unsteady mixed convective stagnation point flow using Tiwari-Das nanofluid model

    NASA Astrophysics Data System (ADS)

    Mabood, F.; Ibrahim, S. M.; Kumar, P. V.; Khan, W. A.

    A mathematical model has been developed using Tiwari-Das model to study the MHD stagnation-point flow and heat transfer characteristics of an electrically conducting nanofluid over a vertical permeable shrinking/stretching sheet in the presence of viscous dissipation. Formulated partial differential equations are converted into a set of ordinary differential equations using suitable similarity transformation. Runge-Kutta-Fehlberg method with shooting technique is applied to solve the resulting coupled ordinary differential equations. The profiles for velocity, temperature, skin friction coefficient and local Nusselt number for various parameters are displayed through graphs and tabular forms. In this problem, we considered two types of nanoparticles, namely, copper (Cu) and Alumina (Al2O3) with water as base fluid.

  13. Sobre o uso das séries de Puiseux em mecanica celeste

    NASA Astrophysics Data System (ADS)

    Miloni, O. I.

    2003-08-01

    Neste trabalho é apresentada uma demonstração do uso dos diferentes desenvolvimentos em séries para as equações de perturbação em Mecânica Celeste no marco Hamiltoniano. Em trabalhos clássicos como os de Poincaré (Poincaré, 1893) por exemplo, já esta planteado o uso de potências não inteiras no pequeno parâmetro, o que evidencia a não analiticidade das funções quando uma ressonância ocorre. Nestes trabalhos os desenvolvimentos são na raíz quadrada da massa de Júpiter (o pequeno parâmetro). Mais recentemente (Ferraz-Mello, 1985) outros tipos de desenvolvimentos foram aplicados modificando substancialmente as ordens de grandeza e a velocidade de convergência das séries. Com esta abordagem, os desenvolvimentos foram expressados em termos da raíz cúbica do pequeno parâmetro. Neste trabalho apresentamos um enfoque geral, onde os diferentes tipos de desenvolvimentos em séries de Puiseux (Valiron, 1950) são obtidos a partir da aplicação de Teorema de Preparação de Weierstrass (Goursat, 1916) considerando a equação de Hamilton-Jacobi como uma equação algébrica. Os resultados são aplicados ao problema restrito dos três corpos em ressonância de primeira ordem e, dependendo da grandeza da excentricidade do asteróide em relação à de Júpiter, obtemos os diferentes desenvolvimentos, em raíz quadrada ou raíz cúbica da massa de Júpiter.

  14. Event DAS-444Ø6-6 soybean grown in Brazil is compositionally equivalent to non-transgenic soybean.

    PubMed

    Fast, Brandon J; Galan, Maria P; Schafer, Ariane C

    2016-04-02

    Soybean event DAS-444Ø6-6 is tolerant to the herbicides 2,4-D, glyphosate, and glufosinate. An investigation of potential unintended adverse compositional changes in a genetically modified crop is required to meet government regulatory requirements in various geographies. A study to meet these requirements in Brazil was completed demonstrating compositional equivalency between DAS-444Ø6-6 and non-transgenic soybean. This study supplements the extensive literature supporting transgenesis as less disruptive of crop composition compared with traditional breeding methods.

  15. Latent Factor Structure of the Das-Naglieri Cognitive Assessment System: A Confirmatory Factor Analysis in a Chinese Setting

    ERIC Educational Resources Information Center

    Deng, Ci-ping; Liu, Ming; Wei, Wei; Chan, Raymond C. K.; Das, J. P.

    2011-01-01

    This study aims to measure the psychometric properties of the Das-Naglieri Cognitive Assessment System (D-N CAS) and to determine its clinical utility in a Chinese context. Confirmatory factor analysis (CFA) was conducted to examine the construct validity of the Chinese version of the D-N CAS among a group of 567, normally developed children.…

  16. Concurrent Validity of the WISC-IV and DAS-II in Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Kuriakose, Sarah

    2014-01-01

    Cognitive assessments are used for a variety of research and clinical purposes in children with autism spectrum disorder (ASD). This study establishes concurrent validity of the Wechsler Intelligence Scales for Children-fourth edition (WISC-IV) and Differential Ability Scales-second edition (DAS-II) in a sample of children with ASD with a broad…

  17. Measuring Primary Teachers' Attitudes toward Teaching Science: Development of the Dimensions of Attitude toward Science (DAS) Instrument

    ERIC Educational Resources Information Center

    van Aalderen-Smeets, Sandra; Walma van der Molen, Juliette

    2013-01-01

    In this article, we present a valid and reliable instrument which measures the attitude of in-service and pre-service primary teachers toward teaching science, called the Dimensions of Attitude Toward Science (DAS) Instrument. Attention to the attitudes of primary teachers toward teaching science is of fundamental importance to the…

  18. Planning Ability across Ranges of Intellectual Ability: An Examination of the Luria-Das Information-Processing Model.

    ERIC Educational Resources Information Center

    McCallum, R. Steve; And Others

    1988-01-01

    Based on Luria-Das information processing theory, hypothesized that 26 educable mentally retarded children would score significantly less well on relatively pure measures of planning ability than would 13 younger average ability students after students were matched on cognitive processing ability. Hypothesis was not supported by study. (Author/NB)

  19. Test Review: Naglieri, J. A., Das, J. P., & Goldstein, S. (2014). Cognitive Assessment System-Second Edition (2nd Ed.)

    ERIC Educational Resources Information Center

    McGill, Ryan J.

    2015-01-01

    The Cognitive Assessment System-Second Edition (CAS2) is an individually administered measure of cognitive ability designed for children and adolescents ages 5 through 18 years. The measure, authored by Jack A. Naglieri, J. P. Das, and Sam Goldstein, was published by Pro-Ed in 2014 and is the first revision of the Cognitive Assessment System (CAS;…

  20. Impaired Left Ventricular Diastolic Functions and Thickened Epicardial Adipose Tissue in Rheumatoid Arthritis Patients is Correlated with DAS-28 Score

    PubMed Central

    Alpaydın, Sertac; Buyukterzi, Zafer; Akkurt, Halil Ekrem; Yılmaz, Halim

    2017-01-01

    Background Rheumatoid arthritis (RA) is a chronic inflammatory disease that is known to be associated with high cardiovascular (CV) morbidity and mortality. In this study, we aimed to demonstrate whether RA disease activity reflected with disease activity score-28 (DAS-28) had an impact on left ventricular diastolic functions and epicardial adipose tissue (EAT) thickness in RA patients with no traditional CV risk factors. Methods In this retrospective study, 41 patients newly diagnosed with RA were included. In addition to medical history, detailed physical examination findings and laboratory tests, left ventricular systolic and diastolic functions, chamber dimensions, and EAT thickness were evaluated with transthoracic echocardiography in the study population. Results This study included 41 subjects with a median age of 45 years (38.00-55.50), of which 29.27% were male. In the binomial logistic regression analysis, DAS-28 score was found to be an independent associate of diastolic dysfunction, Additionally, DAS-28 was found to be independently associated with EAT thickness. Conclusions Patients with high DAS-28 score should be evaluated thoroughly for CV disease, and patients should undergo advanced diagnostic studies as required and receive appropriate treatment. PMID:28344422

  1. Phase Velocity and Full-Waveform Analysis of Co-located Distributed Acoustic Sensing (DAS) Channels and Geophone Sensor

    NASA Astrophysics Data System (ADS)

    Parker, L.; Mellors, R. J.; Thurber, C. H.; Wang, H. F.; Zeng, X.

    2015-12-01

    A 762-meter Distributed Acoustic Sensing (DAS) array with a channel spacing of one meter was deployed at the Garner Valley Downhole Array in Southern California. The array was approximately rectangular with dimensions of 180 meters by 80 meters. The array also included two subdiagonals within the rectangle along which three-component geophones were co-located. Several active sources were deployed, including a 45-kN, swept-frequency, shear-mass shaker, which produced strong Rayleigh waves across the array. Both DAS and geophone traces were filtered in 2-Hz steps between 4 and 20 Hz to obtain phase velocities as a function of frequency from fitting the moveout of travel times over distances of 35 meters or longer. As an alternative to this traditional means of finding phase velocity, it is theoretically possible to find the Rayleigh-wave phase velocity at each point of co-location as the ratio of DAS and geophone responses, because DAS is sensitive to ground strain and geophones are sensitive to ground velocity, after suitable corrections for instrument response (Mikumo & Aki, 1964). The concept was tested in WPP, a seismic wave propagation program, by first validating and then using a 3D synthetic, full-waveform seismic model to simulate the effect of increased levels of noise and uncertainty as data go from ideal to more realistic. The results obtained from this study provide a better understanding of the DAS response and its potential for being combined with traditional seismometers for obtaining phase velocity at a single location. This analysis is part of the PoroTomo project (Poroelastic Tomography by Adjoint Inverse Modeling of Data from Seismology, Geodesy, and Hydrology, http://geoscience.wisc.edu/feigl/porotomo).

  2. DAS181 for Treatment of Parainfluenza Virus Infections in Hematopoietic Stem Cell Transplant Recipients at a Single Center.

    PubMed

    Salvatore, Mirella; Satlin, Michael J; Jacobs, Samantha E; Jenkins, Stephen G; Schuetz, Audrey N; Moss, Ronald B; Van Besien, Koen; Shore, Tsiporah; Soave, Rosemary

    2016-05-01

    Parainfluenza virus (PIV) causes severe respiratory infections in hematopoietic stem cell transplant (HSCT) recipients. Currently, no effective therapies are available. DAS181 is a novel antiviral agent that inhibits attachment of PIV to respiratory cells, but clinical data on the use of DAS181 for PIV infection are limited to case reports. We report the clinical manifestations and outcomes of 16 HSCT recipients who received DAS181 daily for the treatment of PIV infection through a compassionate-use protocol or a single-arm clinical trial. Of the 16 patients (clinical trial: 9; compassionate use: 7), 13 were allogeneic HSCT recipients and 8 had graft-versus-host disease. PIV types were 3 (n = 7), 4 (n = 5), 1 (n = 3), and type 3 and 4 coinfection (n = 1). Fourteen patients had pneumonia. All patients presented with cough, 14 had dyspnea, 11 had hypoxia, and 8 had a fever. Patients received 5 to 10 days of treatment. Nine patients (56%) had a complete clinical response after DAS181 therapy and 4 (25%) had a partial response. The 3 patients without a clinical response had coinfections with other pathogens. Of the 7 patients with virologic and spirometric data, 5 had >1-log reduction in nasopharyngeal swab PIV viral load and 4 had improved forced expiratory volumes by the end of treatment. Three patients (19%) died within 30 days and 2 of these deaths were related to PIV infection. Our data suggest that DAS181 may be an effective therapy for PIV pneumonia in HSCT recipients. Randomized placebo-controlled trials are needed to better evaluate its efficacy.

  3. (Re)locating (I)dentity With(in) Politicized (Re)presentation of Fe/Male Body in Kamala Das' Poetry

    ERIC Educational Resources Information Center

    Sultana, Sharmin; Sarwar, Nadia

    2016-01-01

    This paper is going to argue that the selected poems of renowned Indian poet Kamala Das are inclined to relocate both feminine and masculine identity through the politicized representation of body. Kamala Das' representation of body in her poems has always been viewed as a medium of re-historicizing the pain, sufferings, and psychological trauma…

  4. Common Data Acquisition Systems (DAS) Software Development for Rocket Propulsion Test (RPT) Test Facilities

    NASA Technical Reports Server (NTRS)

    Hebert, Phillip W., Sr.; Davis, Dawn M.; Turowski, Mark P.; Holladay, Wendy T.; Hughes, Mark S.

    2012-01-01

    The advent of the commercial space launch industry and NASA's more recent resumption of operation of Stennis Space Center's large test facilities after thirty years of contractor control resulted in a need for a non-proprietary data acquisition systems (DAS) software to support government and commercial testing. The software is designed for modularity and adaptability to minimize the software development effort for current and future data systems. An additional benefit of the software's architecture is its ability to easily migrate to other testing facilities thus providing future commonality across Stennis. Adapting the software to other Rocket Propulsion Test (RPT) Centers such as MSFC, White Sands, and Plumbrook Station would provide additional commonality and help reduce testing costs for NASA. Ultimately, the software provides the government with unlimited rights and guarantees privacy of data to commercial entities. The project engaged all RPT Centers and NASA's Independent Verification & Validation facility to enhance product quality. The design consists of a translation layer which provides the transparency of the software application layers to underlying hardware regardless of test facility location and a flexible and easily accessible database. This presentation addresses system technical design, issues encountered, and the status of Stennis development and deployment.

  5. Crystal Structures of the Global Regulator DasR from Streptomyces coelicolor: Implications for the Allosteric Regulation of GntR/HutC Repressors

    PubMed Central

    Fillenberg, Simon B.; Friess, Mario D.; Körner, Samuel; Böckmann, Rainer A.; Muller, Yves A.

    2016-01-01

    Small molecule effectors regulate gene transcription in bacteria by altering the DNA-binding affinities of specific repressor proteins. Although the GntR proteins represent a large family of bacterial repressors, only little is known about the allosteric mechanism that enables their function. DasR from Streptomyces coelicolor belongs to the GntR/HutC subfamily and specifically recognises operators termed DasR-responsive elements (dre-sites). Its DNA-binding properties are modulated by phosphorylated sugars. Here, we present several crystal structures of DasR, namely of dimeric full-length DasR in the absence of any effector and of only the effector-binding domain (EBD) of DasR without effector or in complex with glucosamine-6-phosphate (GlcN-6-P) and N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Together with molecular dynamics (MD) simulations and a comparison with other GntR/HutC family members these data allowed for a structural characterisation of the different functional states of DasR. Allostery in DasR and possibly in many other GntR/HutC family members is best described by a conformational selection model. In ligand-free DasR, an increased flexibility in the EBDs enables the attached DNA-binding domains (DBD) to sample a variety of different orientations and among these also a DNA-binding competent conformation. Effector binding to the EBDs of DasR significantly reorganises the atomic structure of the latter. However, rather than locking the orientation of the DBDs, the effector-induced formation of β-strand β* in the DBD-EBD-linker segment merely appears to take the DBDs ‘on a shorter leash’ thereby impeding the ‘downwards’ positioning of the DBDs that is necessary for a concerted binding of two DBDs of DasR to operator DNA. PMID:27337024

  6. The Trigger and Data Acquisition System (TriDAS) of the KM3NeT experiment

    NASA Astrophysics Data System (ADS)

    Pellegrino, C.; KM3NeT Collaboration

    2016-01-01

    Starting from 2015, the new generation underwater high energy neutrino telescope, KM3NeT, is being installed in the Mediterranean Sea. During Phase 1, 32 Detection Units (8 tower-like and 24 string-like) will be deployed in the Ionian Sea, about 100km offshore Portopalo di Capo Passero, Sicily, and 7 string-like DUs will be deployed in the MEUST site, offshore Toulon in France. During Phase 2, several hundreds of DUs will be added to the Phase 1 detector, reaching an effective detection volume of some cubic kilometres. In this contribution the Trigger and Data Acquisition System (TriDAS) of the string-based detector is described. The TriDAS is designed to scale with the detector size, allowing the read-out and the on-line trigger of data from both Phase 1 and Phase 2, whose continuous throughputs are expected to be about 10Gbps and more than 250Gbps, respectively.

  7. MoSST DAS: The First Working Geomagnetic Data Assimilation System

    NASA Technical Reports Server (NTRS)

    Kuang, Weijia; Wei, Zigang; Tangborn, Andrew

    2011-01-01

    The Earth possesses an internal magnetic field (geomagnetic field) generated by convection in the outer core (geodynamo). Previous efforts have been focused along two distinct paths: (1) numerical geodynamo modeling to understand the origin of the geomagnetic field, and the mechanisms of geomagnetic secular variations (SV); and (2) geomagnetic field modeling to map the spatial/temporal variations of the field from geomagnetic data, and to derive core properties, e.g. inversion of core flow near the core-mantle boundary (CMB). Geomagnetic data assimilation is a new approach emerged over the past 5 years: surface observations are assimilated with geodynamo models for better understanding of the core dynamical state, and accurately prediction of SV. In collaboration with several geomagnetic research groups, we have developed the first working geomagnetic data assimilation system, Modular, Scalable, Self-consistent, and Three-dimensional (MoSST) DAS, that includes the MoSST numerical dynamo model; 7000 years of geomagnetic field maps from several field models utilizing satellite and ground observatory data, historical magnetic records and archeo/paleo magnetic data; and an ensemble based optimal interpolation (01) assimilation algorithm. With this system, we have demonstrated clearly that the assimilated core dynamical state is substantially different from those of pure geodynamo simulations. Ensemble assimilation runs also show the convergence of the assimilated solutions inside the core, suggesting that the simulation state is pulled closer to the truth via data assimilation. The forecasts from this system are also very accurate: the 5-year forecast of the geomagnetic field agrees very well with the observations; and the 5-year secular variation forecast is more accurate than the IGRF SV forecast models in the past. Using geomagnetic records up to 2009, we have made an SV forecast for the period from 2010-2015, and is a candidate SV model for IGRF-11.

  8. Sensitivity of Global Modeling Initiative CTM predictions of Antarctic ozone recovery to GCM and DAS generated meteorological fields

    SciTech Connect

    Rotman, D; Bergmann, D

    2003-12-04

    We use the Global Modeling Initiative chemistry and transport model to simulate the evolution of stratospheric ozone between 1995 and 2030, using boundary conditions consistent with the recent World Meteorological Organization ozone assessment. We compare the Antarctic ozone recovery predictions of two simulations, one driven by meteorological data from a general circulation model (GCM), the other using the output of a data assimilation system (DAS), to examine the sensitivity of Antarctic ozone recovery predictions to the characteristic dynamical differences between GCM and DAS-generated meteorological data. Although the age of air in the Antarctic lower stratosphere differs by a factor of 2 between the simulations, we find little sensitivity of the 1995-2030 Antarctic ozone recovery between 350 K and 650 K to the differing meteorological fields, particularly when the recovery is specified in mixing ratio units. Relative changes are smaller in the DAS-driven simulation compared to the GCM-driven simulation due to a surplus of Antarctic ozone in the DAS-driven simulation which is not consistent with observations. The peak ozone change between 1995 and 2030 in both simulations is {approx}20% lower than photochemical expectations, indicating that changes in ozone transport at 450 K between 1995 and 2030 constitute a small negative feedback. Total winter/spring ozone loss during the base year (1995) of both simulations and the rate of ozone loss during August and September is somewhat weaker than observed. This appears to be due to underestimates of Antarctic Cl{sub y} at the 450 K potential temperature level.

  9. Predictors of European League Against Rheumatism (EULAR) good response, DAS-28 remission and sustained responses to TNF-inhibitors in rheumatoid arthritis: a prospective study in refractory disease.

    PubMed

    Mohammed, Reem Hamdy A; Farahat, Faisal; Kewan, Hanady H; Bukhari, Mohammed A

    2015-01-01

    The aim of this study was to survey factors related to EULAR good response, the DAS-28 definition of remission, ACR 50 response, sustained response to tumor necrosis factor inhibitors (TNF-I) therapy in biologic naïve patients with refractory rheumatoid arthritis. This was a single center observational clinical prospective 2 years' study, EULAR response criteria, DAS 28, HAQ and radiographic changes were recorded. Eighty patients included (64 females and 16 males, mean age was 48.4 + -17.9 years, mean disease duration 7.3 + -5.9 years). At 6 months 70% achieved EULAR good response, 51.8% achieved DAS-28 remission. Good response/sustained responses inversely correlated with baseline DAS-28 and radiographic erosions P <0.05. EULAR good response/remission by 6 months, sustained response at 2 years positively correlated with the decline in RF titers (r = 0.33, P < 0.05 & r = 0.30, P < 0.03 respectively), negatively correlated with the baseline HAQ. Regression analysis identified higher serum hemoglobin concentration, lower baseline HAQ scores, and the absence of radiographic erosions as significant predictors of good as well as sustained responses after adjustment for potential covariates. Methotrexate was associated with favorable responses and remission at 6 months (ORs = 1.13, 1.30 respectively). The study concluded that a lower baseline DAS-28 and HAQ scores, the lack of radiographic erosions favored EULAR good response and were significant predictors of sustained response to TNF-I.

  10. Properties of Noise Cross Correlation Functions Obtained from a Distributed Acoustic Sensing (DAS) Array at Garner Valley, California

    NASA Astrophysics Data System (ADS)

    Zeng, X.; Lancelle, C.; Thurber, C. H.; Fratta, D.; Wang, H. F.; Chalari, A.; Clarke, A.

    2015-12-01

    The field test of Distributed Acoustic Sensing (DAS) conducted at Garner Valley, California on September 11-12, 2013 provided a continuous overnight record of ambient noise. The DAS array recorded ground motions every one meter of optical cable that was arranged approximately in the shape of a rectangle with dimensions of 160 m by 80 m. The long dimension of the array was adjacent to a state highway. Three hours of record were used to compute noise cross-correlation functions (NCFs) in one-minute windows. The trace from each sensor channel was pre-processed by downsampling to 200 Hz, followed by normalization in the time-domain and bandpass filtering between 2 and 20 Hz (Bensen et al., 2007). The one-minute NCFs were then stacked using the time-frequency domain phase-weighted stacking method (Schimmel & Gallart, 2007). The NCFs between channels were asymmetrical reflecting the direction of traffic noise. The group velocities were found using the frequency-time analysis method. The energy was concentrated between 5 and 15 Hz, which falls into the typical traffic noise frequency band. The resulting velocities were between 100 and 300 m/s for frequencies between 10 and 20 Hz, which are in the same range as described in the results for surface-wave dispersion obtained using an active source for the same site (Lancelle et al., 2015). The group velocity starts to decrease for frequencies greater than ~10 Hz, which was expected on the basis of a previous shear-wave velocity model (Steidl et al., 1996). Then, the phase velocity was calculated using the multichannel analysis of surface wave technique (MASW - Park et al., 1999) with 114 NCFs spaced one meter apart. The resulting dispersion curve between 5 and 15 Hz gave phase velocities that ranged from approximately 170 m/s at 15 Hz to 250 m/s at 5 Hz. These results are consistent with other results of active-source DAS and seismometer records obtained at the Garner Valley site (e.g., Stokoe et al. 2004). This analysis is

  11. Insect-protected event DAS-81419-2 soybean (Glycine max L.) grown in the United States and Brazil is compositionally equivalent to nontransgenic soybean.

    PubMed

    Fast, Brandon J; Schafer, Ariane C; Johnson, Tempest Y; Potts, Brian L; Herman, Rod A

    2015-02-25

    The transgenic soybean event DAS-81419-2 contains genes that encode the Cry1F, Cry1Ac, and PAT proteins. Cry1F and Cry1Ac provide protection against key lepidopteran insect pests, while PAT confers tolerance to the herbicide glufosinate. To satisfy regulatory requirements for the safety evaluation of transgenic crops, studies were conducted in the United States and Brazil to evaluate the nutrient and antinutrient composition of event DAS-81419-2 soybean. On the basis of the results of these studies, event DAS-81419-2 soybean is compositionally equivalent to nontransgenic soybean. This conclusion concurs with numerous other published studies in soybean and other crops where compositional equivalence between the transgenic crop and its nontransgenic comparator has been demonstrated.

  12. Insect-Protected Event DAS-81419-2 Soybean (Glycine max L.) Grown in the United States and Brazil Is Compositionally Equivalent to Nontransgenic Soybean

    PubMed Central

    2015-01-01

    The transgenic soybean event DAS-81419-2 contains genes that encode the Cry1F, Cry1Ac, and PAT proteins. Cry1F and Cry1Ac provide protection against key lepidopteran insect pests, while PAT confers tolerance to the herbicide glufosinate. To satisfy regulatory requirements for the safety evaluation of transgenic crops, studies were conducted in the United States and Brazil to evaluate the nutrient and antinutrient composition of event DAS-81419-2 soybean. On the basis of the results of these studies, event DAS-81419-2 soybean is compositionally equivalent to nontransgenic soybean. This conclusion concurs with numerous other published studies in soybean and other crops where compositional equivalence between the transgenic crop and its nontransgenic comparator has been demonstrated. PMID:25641393

  13. Priming index of the Spanish word fragments from the Dasí, Soler, and Ruiz (2004) database.

    PubMed

    Dasí, Carmen; Soler, María José; Ruiz, Juan Carlos

    2007-08-01

    Word-fragment completion is a frequently used test in implicit memory research. A database of 196 Spanish fragments was recently published (Dasí, Soler, & Ruiz, 2004) in which the fragments were described for indices, such as difficulty, familiarity, frequency, number of meanings, and so on (www.psychonomic.org/archive). In this work, a new index, the priming index, is described for the same 196 fragments. This index is calculated for each fragment by subtracting the difficulty index (the proportion of correct completion when the fragment is not studied) from the proportion of correct completion when the fragment is studied, and it means the capacity of an item to be primed. In order to determine whether the new index performs well, we have replicated some important experimental effects, such as priming, frequency, and difficulty. We consider that this index can help researchers to better select stimuli for fragment-completion tasks.

  14. Development of a surface-wave imaging system for geotechnical applications based on distributed acoustic sensing (DAS) and ambient noise interferometry

    NASA Astrophysics Data System (ADS)

    Ajo Franklin, J. B.; Daley, T. M.; Freifeld, B. M.; Tang, D. G.; Zhang, R.; Wagner, A. M.; Dou, S.; Lindsey, N.; Bjella, K.; Pevzner, R.

    2014-12-01

    Distributed fiber-optic sensing methods have been used since the 1980's for continuous monitoring of near-surface soil properties, typically exploiting Raman scattering to measure temperature (DTS) or stimulated Brillouin scattering to measure strain (DSS). Recent advances in high speed measurement of Rayleigh scattering has enabled distributed recording of seismic waves over long sections of fiber; this approach, referred to as distributed acoustic sensing (DAS) has the potential to allow nearly continuous monitoring of near-surface mechanical properties, a crucial target for geotechnical management of infrastructure dependent on soil strength. We present initial results from our effort to build a real-time soil property monitoring system based on DAS; our approach employs seismic interferometry and dispersion analysis of ambient noise generated by infrastructure to provide a continuously updated model of shear modulus. Our preliminary results include an in-depth investigation of DAS fiber response in the context of active sources; this component of our study verifies classical models for the azimuthal response of straight fibers to propagating surface waves. We also explore the "noisescape" of linear infrastructure and show a usable seismic signal band of 8-40 hz at a series of sites, primarily consisting of Rayleigh waves. Finally, we present preliminary results from a DAS monitoring array installed at the Richmond Field Station near a heavily used road and compare interferometric processing of the acquired data to that generated by surface deployment of geophones.

  15. Novas determinações dos parâmetros atmosféricos das estrelas anãs brancas DA

    NASA Astrophysics Data System (ADS)

    Giovannini, O.; Costa, A. F. M.; Kepler, S. O.

    2003-08-01

    Nós temos selecionado uma amostra de estrelas anãs brancas DA (atmosfera de hidrogênio) a partir dos índices de Strömgren cujos valores estão próximos a região de instabilidade das estrelas anãs brancas DA variáveis, as chamadas estrelas DAV ou ZZ Ceti. O objetivo é determinar os parâmetros fundamentais (temperatura efetiva, Teff, aceleração da gravidade, log g, e massa) destas estrelas para verificar quais os parâmetros estelares estão envolvidos com o mecanismo de pulsação das estrelas DAV. Nós obtemos, até agora, mais de 120 espectros óticos de estrelas DA. Entre as estrelas selecionadas há 20 estrelas variáveis (DAV). Assim, podemos verificar se existem ou não estrelas não variáveis dentro da faixa de instabilidade das estrelas ZZ Ceti. Neste trabalho nós apresentamos a determinação dos parâmetros atmosféricos (temperatura efetiva, Teff, e aceleração da gravidade, log g) das estrelas anãs brancas DA usando os novos modelos de atmosfera ML2/a = 0.6. Estes modelos têm sido utilizados recentemente por fornecerem uma excelente consistência interna na determinação das temperaturas nas regiões do ultra-violeta e ótico. Os parâmetros atmosféricos são determinados espectroscopicamente através da comparação do fluxo de energia das linhas de Balmer (Hb à H9) entre os espectros observados e sintéticos (gerados pelos modelos de atmosfera). As temperaturas obtidas com os novos modelos são, em geral, menores (~ 1000 K menos) que as temperaturas determinadas anteriormente, com modelos ML1. Os valores de log g não mudaram significativamente (menos de 10%). A faixa de instabilidade das DAVs está entre 11000 e 13000 K, consistente com dados de outros autores.

  16. Three genes encoding citrate synthases in Saccharopolyspora erythraea are regulated by the global nutrient-sensing regulators GlnR, DasR, and CRP.

    PubMed

    Liao, Cheng-Heng; Yao, Li-Li; Ye, Bang-Ce

    2014-10-08

    Saccharopolyspora erythraea has three citrate synthases encoded by gltA-2, citA, and citA4. Here, we characterized and identified the expression and regulatory properties of these synthases. Three pleiotropic global regulatory proteins of S. erythraea - CRP, GlnR, and DasR - are involved in carbon metabolism, nitrogen metabolism, and amino-sugar (chitin and GlcNAc) metabolism. Using electrophoretic mobility shift assays (EMSAs), we identified these regulators as proteins that bind directly to the promoter regions of all citrate synthase genes (gltA-2, citA, and citA4). Footprinting assays indicated the exact protect sequences of CRP, GlnR, and DasR on the promoter region of gltA-2, revealing binding competition between GlnR and DasR. Moreover, by comparing the transcription levels of citrate synthase genes between parental and glnR mutant or dasR mutant strains, or by comparing the transcription response of citrate synthases under various nutrient conditions, we found that GlnR and DasR negatively regulated citA and citA4 transcription but had no regulatory effects on the gltA-2 gene. Although no CRP mutant was available, the results indicated that CRP was a cAMP-binding receptor affecting gltA-2 transcription when the intracellular cAMP concentration increased. Thus, an overall model of CS regulation by C and/or N metabolism regulators and cAMP receptor protein was proposed.

  17. Evaluation of corn grain with the genetically modified input trait DAS-59122-7 fed to growing-finishing pigs.

    PubMed

    Stein, H H; Rice, D W; Smith, B L; Hinds, M A; Sauber, T E; Pedersen, C; Wulf, D M; Peters, D N

    2009-04-01

    A growth performance experiment was conducted to assess the feeding value of a double-stacked transgenic corn grain for growing-finishing pigs. The genetically modified corn grain contained event DAS-59122-7, which expresses the Cry34/35Ab1 binary insecticidal protein for the control of corn rootworm. This modified transgenic grain is resistant to western corn rootworm and is also tolerant to herbicides containing the active ingredient glufosinate-ammonium. The modified grain (59122), a nontransgenic near-isoline grain (control corn), and a commercial corn (Pioneer brand hybrid 35P12) were grown in a 2005 production trial in individually isolated plots that were located 201 m apart. A total of 108 pigs were allotted to corn-soybean meal diets containing 1 of the 3 grains as the sole source of corn. There were 3 pigs per pen and 12 replicate pens per treatment. Pigs were fed grower diets from 37 to 60 kg, early finisher diets from 60 to 90 kg, and late finisher diets from 90 to 127 kg. Within each phase, data for ADG, ADFI, and G:F were calculated. At the conclusion of the experiment, pigs were slaughtered and data for carcass quality were collected. Differences between 59122 and the control corn were evaluated, with statistical significance at P<0.05. No differences in ADG, ADFI, or G:F between pigs fed the control corn and pigs fed the modified corn were observed during the grower, early finisher, or late finisher phases. For the entire experimental period, no difference between pigs fed the control and the 59122 corn were observed for final BW (128.9 vs. 127.1 kg), ADG (1.02 vs. 1.00 kg), ADFI (2.88 vs. 2.80 kg), or G:F (0.356 vs. 0.345 kg/kg). Likewise, no differences in dressing percentage (76.48 vs. 76.30%), LM area (49.8 vs. 50.4 cm(2)), 10th-rib back fat (2.20 vs. 2.12 cm), and carcass lean content (52.9 vs. 53.4%) were observed between pigs fed the control and the 59122 corn grain. It was concluded that the nutritional value of the modified transgenic corn

  18. Simulation of the single-vibronic-level emission spectra of HAsO and DAsO

    NASA Astrophysics Data System (ADS)

    Mok, Daniel K. W.; Lee, Edmond P. F.; Dyke, John M.

    2016-05-01

    The single-vibronic-level (SVL) emission spectra of HAsO and DAsO have been simulated by electronic structure/Franck-Condon factor calculations to confirm the spectral molecular carrier and to investigate the electronic states involved. Various multi-reference (MR) methods, namely, NEVPT2 (n-electron valence state second order perturbation theory), RSPT2-F12 (explicitly correlated Rayleigh-Schrodinger second order perturbation theory), and MRCI-F12 (explicitly correlated multi-reference configuration interaction) were employed to compute the geometries and relative electronic energies for the X ˜ 1 A ' and A ˜ 1 A ″ states of HAsO. These are the highest level calculations on these states yet reported. The MRCI-F12 method gives computed T0 (adiabatic transition energy including zero-point energy correction) values, which agree well with the available experimental T0 value much better than previously computed values and values computed with other MR methods in this work. In addition, the potential energy surfaces of the X ˜ 1 A ' and A ˜ 1 A ″ states of HAsO were computed using the MRCI-F12 method. Franck-Condon factors between the two states, which include anharmonicity and Duschinsky rotation, were then computed and used to simulate the recently reported SVL emission spectra of HAsO and DAsO [R. Grimminger and D. J. Clouthier, J. Chem. Phys. 135, 184308 (2011)]. Our simulated SVL emission spectra confirm the assignments of the molecular carrier, the electronic states involved, and the vibrational structures observed in the SVL emission spectra but suggest a loss of intensity in the reported experimental spectra at the low emission energy region almost certainly due to a loss of responsivity near the cutoff region (˜800 nm) of the detector used. Computed and experimentally derived re (equilibrium) and/or r0 {the (0,0,0) vibrational level} geometries of the two states of HAsO are discussed.

  19. Nutrient budgets (C, N and P) and trophic dynamics of a Brazilian tropical estuary: Barra das Jangadas.

    PubMed

    Noriega, Carlos E D; Araujo, Moacyr

    2011-06-01

    This paper focuses on the nutrient dynamics of a tropical estuary on the northeastern Brazilian coast, studied using the LOICZ biogeochemical budgeting protocol. We describe the methodology and assumptions underlying this model. Input data (monthly for rainfall, evaporation, river discharge, and concentrations of salt, phosphorus and nitrogen) were obtained during field campaigns in the Barra das Jangadas Estuary (BJE) over a 5 years period (1999 to 2003). Mass balance results indicate large inputs of nutrients to the system. The model shows that the seasonal variation of the Net Ecosystem Metabolism (NEM) indicates that the system passes from a stage of organic matter liquid production and mineralization during the dry season (-0.5 mmoles C m(-2) d(-1)) to liquid mineralization during the rainy season (-19 mmoles C m(-2) d(-1)). We suggest that the system varies slightly between autotrophy and heterotrophy during the year due to the rainfall regime, human activities in the basin (density population and sugarcane plantations), and associated DIP riverine loads. High per capita loads of N and P indicate a high population density and high runoff. The application of flux balance modeling was useful to understand the nutrient dynamics of this typical small tropical estuary.

  20. Stacking transgenic event DAS-Ø15Ø7-1 alters maize composition less than traditional breeding.

    PubMed

    Herman, Rod A; Fast, Brandon J; Scherer, Peter N; Brune, Alyssa M; de Cerqueira, Denise T; Schafer, Barry W; Ekmay, Ricardo D; Harrigan, George G; Bradfisch, Greg A

    2017-02-20

    The impact of crossing ("stacking") genetically modified (GM) events on maize-grain biochemical composition was compared with the impact of generating non-GM hybrids. The compositional similarity of seven GM stacks containing event DAS-Ø15Ø7-1 and their matched non-GM near-isogenic hybrids (iso-hybrids) was compared with the compositional similarity of concurrently grown non-GM hybrids and these same iso-hybrids. Scatter plots were used to visualize comparisons among hybrids and a coefficient of identity (percent of variation explained by line of identity) was calculated to quantify the relationships within analyte profiles. The composition of GM breeding stacks was more similar to the composition of iso-hybrids than was the composition of non-GM hybrids. Non-GM breeding more strongly influenced crop composition than did transgenesis or stacking of GM events. These findings call into question the value of uniquely requiring composition studies for GM crops, especially for breeding stacks composed of GM events previously found to be compositionally normal. This article is protected by copyright. All rights reserved.

  1. Acute postsurgical suppurative parotitis: current prevalence at Hospital das Clínicas, São Paulo University Medical School.

    PubMed

    Belczak, Sergio Quilici; Cleva, Roberto D E; Utiyama, Edivaldo M; Cecconello, Ivan; Rasslan, Samir; Parreira, José Gustavo

    2008-01-01

    Postsurgical acute suppurative parotitis is a bacterial gland infection that occurs from a few days up to some weeks after abdominal surgical procedures. In this study, the authors analyze the prevalence of this complication in Hospital das Clínicas/São Paulo University Medical School by prospectively reviewing the charts of patients who underwent surgeries performed by the gastroenterological and general surgery staff from 1980 to 2005. Diagnosis of parotitis or sialoadenitis was analyzed. Sialolithiasis and chronic parotitis previous to hospitalization were exclusion criteria. In a total of 100,679 surgeries, 256 patients were diagnosed with parotitis or sialoadenitis. Nevertheless, only three cases of acute postsurgical suppurative parotitis associated with the surgery were identified giving an incidence of 0.0028%. All patients presented with risk factors such as malnutrition, immunosuppression, prolonged immobilization and dehydration. In the past, acute postsurgical suppurative parotitis was a relatively common complication after major abdominal surgeries. Its incidence decreased as a consequence of the improvement of perioperative antibiotic therapy and postoperative support. In spite of the current low incidence, we believe it is important to identify risks and diagnose as quick as possible, in order to introduce prompt and appropriate therapeutic measures and avoid potentially fatal complications with the evolution of the disease.

  2. Free convection in a parallelogrammic porous cavity filled with a nanofluid using Tiwari and Das' nanofluid model.

    PubMed

    Ghalambaz, Mohammad; Sheremet, Mikhail A; Pop, Ioan

    2015-01-01

    The free convection heat transfer of Cu-water nanofluids in a parallelogrammic enclosure filled with porous media is numerically analyzed. The bottom and top of the enclosure are insulated while the sidewalls are subject to limited temperature difference. The Darcy flow and the Tiwari and Das' nanofluid models are considered. The governing dimensionless partial differential equations are numerically solved using a finite difference code. The results are reported for isotherms and streamlines as well as Nusselt number as a function of the volume fraction of nanoparticles, porosity, types of the porous matrix, inclination angle, aspect ratio and different Rayleigh numbers. It is found that the presence of the nanoparticles inside the enclosure deteriorates the heat transfer rate, which is caused due to the increase of dynamic viscosity by the presence of nanoparticles. Therefore, in applications in which the nanofluids are used for their advantages, such as enhanced dielectric properties or antibacterial properties, more caution for the heat transfer design of the enclosure is necessary.

  3. Wood anatomy of Mollinedia glabra (Spreng.) Perkins (Monimiaceae) in two Restinga Vegetation Formations at Rio das Ostras, RJ, Brazil.

    PubMed

    Novaes, Fernanda da S; Callado, Cátia H; Pereira-Moura, Maria Verônica L; Lima, Helena R P

    2010-12-01

    This paper aimed to characterize the anatomical structure of the wood of specimens of Mollinedia glabra (Spreng.) Perkins growing in two contiguous formations of restinga vegetation at Praia Virgem, in the municipality of Rio das Ostras, RJ. Both the Open Palmae (OPS) and the Sandy Strip Closed Shrub (SSCS) formations are found in coastal regions that receive between 1,100 and 1,300 mm of rainfall per year. Sapwood samples were collected in both formations. Typical anatomical features for this species include: solitary vessels, radial multiples or clusters elements, that are circular to angular in outline, 5-15 barred scalariform perforation plates, wood parenchyma scanty, septate fiber-tracheids, and wide multiseriate rays with prismatic crystals. Statistical analyses indicated a significant increase in the frequency of vessel elements and an increase in fiber-tracheid diameters in OPS individuals. These characteristics are considered structural adaptations to increased water needs caused by a greater exposure to sunlight. Continuous pruning may be responsible for the tyloses observed in OPS plants. The greater lengths and higher frequencies of the rays in SSCS trees may be due to the greater diameters of their branches. Our results suggest that M. glabra develops structural adaptations to the restinga micro-environmental variations during its development.

  4. Common Data Acquisition Systems (DAS) Software Development for Rocket Propulsion Test (RPT) Test Facilities - A General Overview

    NASA Technical Reports Server (NTRS)

    Hebert, Phillip W., Sr.; Hughes, Mark S.; Davis, Dawn M.; Turowski, Mark P.; Holladay, Wendy T.; Marshall, PeggL.; Duncan, Michael E.; Morris, Jon A.; Franzl, Richard W.

    2012-01-01

    The advent of the commercial space launch industry and NASA's more recent resumption of operation of Stennis Space Center's large test facilities after thirty years of contractor control resulted in a need for a non-proprietary data acquisition system (DAS) software to support government and commercial testing. The software is designed for modularity and adaptability to minimize the software development effort for current and future data systems. An additional benefit of the software's architecture is its ability to easily migrate to other testing facilities thus providing future commonality across Stennis. Adapting the software to other Rocket Propulsion Test (RPT) Centers such as MSFC, White Sands, and Plumbrook Station would provide additional commonality and help reduce testing costs for NASA. Ultimately, the software provides the government with unlimited rights and guarantees privacy of data to commercial entities. The project engaged all RPT Centers and NASA's Independent Verification & Validation facility to enhance product quality. The design consists of a translation layer which provides the transparency of the software application layers to underlying hardware regardless of test facility location and a flexible and easily accessible database. This presentation addresses system technical design, issues encountered, and the status of Stennis' development and deployment.

  5. Das wissenschaftliche Handbuch

    NASA Astrophysics Data System (ADS)

    Luckenbach, Reiner; Sunkel, Josef

    1981-02-01

    The 100th anniversary of Beilstein's Handbook of Organic Chemistry, founded in 1881, merits a brief description of the principal concepts and goals of the literary genre “scientific handbook” in general. Systematic arrangement, critical data and fact evaluation, thoroughness and reliability are among these goals, thus providing the handbook user with a concise compilation of carefully checked and cross-referenced information in his particular field of interest.

  6. Variation of the anthropic vulnerability in Ribeirão das Pedras watershed in Campinas/SP - Brazil.

    NASA Astrophysics Data System (ADS)

    Damame, Desirée; Longo, Regina; Ribeiro, Admilson; Fengler, Felipe

    2015-04-01

    The human actions has caused over the years profound changes in environmental quality in urban ecosystems suffering losses in the quality of air, soil , water and vegetation also the quality of life of the population that inhabit these areas . The study area is characterized by being a highly urbanized watershed, with about 43 % of its area covered by buildings, houses , and commercial and industrial establishments . Called the Ribeirão das Pedras Basin, located in Campinas / SP - Brazil and is bounded by coordinates 22˚47'10 '' and 22˚52'20 '' S , and 47˚ 07'15 '' and 46˚ 02 ' 15' ' . Has an average temperature of 22.4 ° C and average annual rainfall of 1424.5 mm . It has an area of about 42 km² . This is located two universities and a large mall. It also demands a strong agriculture , which occupies about 30 % of the area . It has also been part of two major forest reserves of the municipality, the Forest Santa Geneva and the Forest of Quilombo , both added to other small fragments overlying only about 6% of the total basin area . Avalição to environmental quality , the analysis of the vulnerability of urban watershed becomes an important environmental management tool. The vulnerability can be defined by susceptibility to changes of environment in its initial state , a current tax status by human intervention , and is almost always associated with risk , and the intensity at which such projects in one place, person or structure. In this context , this study aimed to assess environmental vulnerability in an urban watershed coming under increasing human pressures , especially in recent years . For this analysis were prepared soil graphics, slope , elevation and land use and land cover for the years 2009 and 2014 , generating with these , comparative anthropic vulnerability maps of the past five years. Crafting vulnerability maps is a sensitivity in order to enable appropriate management of biotic systems. With the results can be seen that the variation of

  7. Comparative morphology of the reproductive system of seven species of ostariophysan fishes from the upper Das Velhas River, Brazil.

    PubMed

    Melo, Rafael Magno Costa; Gomes, Débora Diniz; Moreira, Davidson Peruci; Gomes, Maysa Regina; Bazzoli, Nilo; Rizzo, Elizete

    2017-02-01

    The success of fishes in different environments is related with the variation of reproductive strategies developed by the systematic group, which is reflected in the morphology of the reproductive system and can have ecological and evolutionary implications. This study comparatively analyzed the morphological characteristics of the male and female reproductive systems of ostariophysan fish species from the upper Das Velhas River in the São Francisco River basin, Brazil. In order to accomplish this, 393 specimens belonging to seven fish species were sampled between April 2010 and June 2015 for histological, ultrastructural, histochemical, and morphometric analyses. All the species examined have anastomosing tubular testes with unrestricted distribution of spermatogonia. Astyanax bimaculatus, A. fasciatus, A. scabripinnis, and Harttia torrenticola had their spermatozoa embedded in a glycoprotein secretion within the tubule lumen. Most species had type I spermiogenesis, whereas Rhamdia quelen had type III spermiogenesis. While all females examined had asynchronous oocyte development, there were remarkable morphological, histochemical, and morphometric differences in the ovarian follicles and enveloping layers. Hoplias malabaricus and H. torrenticola, which exhibit parental care behaviour, had a significantly larger diameter of vitellogenic oocytes and larger spermatozoa nuclei. Apareiodon ibitiensis, H. torrenticola, and A. scabripinnis, species that have rheophilic preferences, exhibited a thicker zona radiata than the other species examined. The follicular cells of R. quelen and H. torrenticola were columnar and produced a jelly coat and mucosubstances, respectively. The females of the seven fish species studied show a correlation of the reproductive strategies with the reproductive system morphology, while males retained more similar morphological characteristics between species. J. Morphol. 278:170-181, 2017. © 2016 Wiley Periodicals,Inc.

  8. Ventos em supergigantes B[e] das nuvens de Magalhães e da Galáxia

    NASA Astrophysics Data System (ADS)

    de Araújo, F. X.; Pilling, D. A.; Pereira, C. B.; Fernandes, M. B.

    2003-08-01

    As Supergigantes B[e] apresentam as seguintes características: (i) alta luminosidade; (ii) espectro típico de estrelas de tipo B; (iii) linhas permitidas e proibidas em emissão de metais de baixa ionização, especialmente FeII; (iv) linhas de Balmer, e por vêzes também dos ions HeI e FeII, com perfis tipo P Cygni indicativos de altas taxas de perda de massa. Atualmente estamos desenvolvendo um projeto que visa comparar as propriedades fisicas (principalmente e v¥) dos ventos destes objetos nas Nuvens de Magalhães e na Galaxia. O objetivo é estudar a influência da metalicidade. No presente painel apresentamos uma determinação das velocidades terminais de 11 estrelas, sendo 4 na GNM (Hen S111, 66, R126 e Hen S93), 4 na PNM (Hen S18, S23, S65 e R4) e 3 na Galaxia (CPD-529243, MWC 300 e GG Car). Nossos dados são espectros de alta resolução obtidos no telescópio 1.52m do ESO com o espectrógrafo FEROS. Para determinar as velocidades terminais usamos as linhas Hd e HeI 3888 Å cujas componentes em absorção costumam estar livres de "blends" e estruturas. Nossos resultados sugerem que as velocidades de expansão na GNM são maiores (ainda que apenas ligeiramente) do que aquelas da PNM, como esperado. No entanto, os objetos da Galaxia não parecem seguir a mesma tendência.

  9. Bottom Characterization with High Resolution Sonar Data and Geochemical Analyses of an Uninvestigated Cone in Lagoa das Furnas on São Miguel Island, Azores Archipelago

    NASA Astrophysics Data System (ADS)

    Andersson, T.

    2015-12-01

    Lagoa das Furnas is a crater lake located in an area exposed to geohazards from earthquakes and volcanic activity on the island São Miguel in the Azores Archipelago. The Furnas volcanic center has a long history of earthquakes and volcanic activity. The area is relatively well studied except for the lake floor. Therefore, a high resolution geophysical and geological mapping survey was conducted at Lagoa das Furnas. Sidescan sonar was used to map the surface of the lake floor and single beam sonar was used to acquire sub-bottom profiles. In addition to the geophysical mapping, sediment surface sampling and core drilling were carried out followed by geochemical analyses of the retrieved material. The mapped data permitted a characterization of the floor of Lagoa das Furnas and revealed several volcanic features including fumarolic activity and a previously uninvestigated volcanic cone in the southern part of the lake. In order to unravel the origin of this cone several methods were applied, including analyses of tephra and minerals collected from the cone itself and from nearby deposits of two known eruptions, Furnas I and Furnas 1630. Sedimentological, petrological, geochemical and geochronological studies of pyroclastic deposits from the cone suggest a subaqueous eruption linked to the Furnas 1630 eruption. The chemistry of glass and crystal fragments sampled from the cone suggests that it is composed of more evolved magma than that of the main Furnas 1630, implying that the lake cone is likely a product of the last eruptional phase. According to historical records, two of three lakes were lost due the Furnas 1630 eruption. The results of this study show that the remaining lake is most likely Lagoa das Furnas, which consequently must have existed before the 1630 eruption.

  10. Soil gas Rn monitoring at Chã das Caldeiras prior the 2014-15 Fogo eruption, Cape Verde

    NASA Astrophysics Data System (ADS)

    Padilla, Germán; Barrancos, José; Dionis, Samara; Fernandes, Paulo; Pérez, Nemesio M.; Sagiya, Takeshi; Padrón, Eleazar; Melián, Gladys V.; Hernández, Pedro A.; Silva, Sónia; Pereira, José Manuel; Rodríguez, Fátima; Asensio-Ramos, María; Calvo, David; Semedo, Helio

    2015-04-01

    Since 2007 the ITER-INVOLCAN/UNICV-OVCV/SNPC research team has implemented a geochemical program for the volcanic surveillance of Fogo volcano by means of applying different geochemical methods in a regularly basis (diffuse degassing surveys, fumarole gas sampling, etc.). This program was improved by setting up a geochemical permanent station (CHA01) to perform continuous measurements of soil gas radon (222Rn) and thoron (220Rn) activities at Chã das Caldeiras, more specific in Portela village, since April 20, 2013. Both gases are characterized to ascend towards the surface mainly through cracks or faults via diffusion and/or advection mechanisms dependent of both soil porosity and permeability, which in turn vary as a function of the stress/strain changes at depth. Measurements of 222Rn and 220Rn activities were performed by an alpha-spectrometer after pumping the soil gas from a thermally isolated PVC pipe inserted 1m in the ground. Even though during the study period the recorded data did not show high 222Rn activity values, a change in the temporal evolution of soil gas 222Rn activity was observed. During the first six months, from April to October, 2013, recorded time series of 222Rn and 220Rn activities showed normal background levels with values of 80.5 and 55.2 Bqm-3, respectively. However, from October, 2013, to February, 2014, 222Rn time series showed an increase trend reaching peak values of 396 Bqm-3 and having an average activity of 134 Bqm-3 until the removal of the station on November 25, 2014 due to the potential danger of being destroyed by the lava flows. The observed increase in the soil gas 222Rn activity from October 2013 to February 2014 occurs almost at the same time of slight observed changes in the vertical displacements detected by the geodetic network installed at the Fogo Island by the ITER-INVOLCAN/UNICV-OVCV/SNPC/Nagoya University research team. Since seismic data are not available, we cannot conclude if the observed changes in soil

  11. Data Integration Acquired from Micro-Uav and Terrestrial Laser Scanner for the 3d Mapping of Jesuit Ruins of São Miguel das Missões

    NASA Astrophysics Data System (ADS)

    Reiss, M. L. L.; da Rocha, R. S.; Ferraz, R. S.; Cruz, V. C.; Morador, L. Q.; Yamawaki, M. K.; Rodrigues, E. L. S.; Cole, J. O.; Mezzomo, W.

    2016-06-01

    The Jesuit Missions the Guaranis were one of the great examples of cultural, social, and scientific of the eighteenth century, which had its decline from successive wars that followed the exchange of territories domain occupied by Portugal and Spain with the Madrid Treaty of January 13, 1750. One of the great examples of this development is materialized in the ruins of 30 churches and villages that remain in a territory that now comprises part of Brazil, Argentina and Paraguay. These Churches, São Miguel das Missões is among the Brazilian ruins, the best preserved. The ruins of São Miguel das Missões were declared a UNESCO World Cultural Heritage in 1983 and the Institute of National Historical Heritage (IPHAN) is the Brazilian Federal agency that manages and maintains this heritage. In order to produce a geographic database to assist the IPHAN in the management of the Ruins of São Miguel das Missões it was proposed a three-dimensional mapping of these ruins never performed in this location before. The proposal is integrated data acquired from multiple sensors: two micro-UAV, an Asctec Falcon 8 (rotary wing) and a Sensefly e-Bee (fixed wing); photos from terrestrial cameras; two terrestrial LIDAR sensors, one Faro Focus 3D S-120 and Optec 3D-HD ILRIS. With this abundance of sensors has been possible to perform comparisons and integration of the acquired data, and produce a 3D reconstruction of the church with high completeness and accuracy (better than 25 mm), as can be seen in the presentation of this work.

  12. Challenges for bathing in rivers in terms of compliance with coliform standards. Case study in a large urbanized basin (das Velhas River, Brazil).

    PubMed

    von Sperling, Marcos; von Sperling, Eduardo

    2013-01-01

    This paper presents a case study on the prospects of bathing in a large water course (das Velhas River, Brazil), which crosses the important metropolitan region of Belo Horizonte (25 municipalities), receiving several point and diffuse discharges. The studies were carried out based on a mathematical simulation of thermotolerant coliforms over 227 km of the river, using an adaptation of the Qual2E model (model Qual-UFMG). Simulations of intervention scenarios were made for the current conditions, with three reference flows for the das Velhas River, tributaries and direct contribution: Q7,10 (representative of low-flow conditions), Q50 (average conditions) and Q10 (rainy season). The intervention scenarios simulated were: (a) current conditions without intervention; (b) scenario with effluent disinfection in the two largest wastewater treatment plants in the basin (around 2.4 million inhabitants); (c) scenario with 95% sewage collection and treatment, with disinfection in all municipalities of the study area; (d) scenario with the calculation of values required for the coverage of sewage treatment and coliform removal efficiencies based on a mathematical optimization process. The monitoring data and results of all simulations indicated improvement in coliform concentration as the river flows downstream. However, results suggested that disinfection per se is not enough. Even under hypothetical conditions of excellent sanitary infrastructure for a developing country, coverage of collection and treatment of 95% of the generated sewage, and treatment with disinfection at all wastewater treatment plants, concentrations of thermotolerant coliforms in das Velhas River are likely to be above the maximum allowable of 1,000 MPN/100 mL for bathing purposes. The mathematical optimization indicated the need for very high percentages of sewage treatment coverage (near 100%, i.e. universality of collection and treatment) and implementation of disinfection in most treatment plants

  13. DasPy 1.0 - the Open Source Multivariate Land Data Assimilation Framework in combination with the Community Land Model 4.5

    NASA Astrophysics Data System (ADS)

    Han, X.; Li, X.; He, G.; Kumbhar, P.; Montzka, C.; Kollet, S.; Miyoshi, T.; Rosolem, R.; Zhang, Y.; Vereecken, H.; Franssen, H.-J. H.

    2015-08-01

    Data assimilation has become a popular method to integrate observations from multiple sources with land surface models to improve predictions of the water and energy cycles of the soil-vegetation-atmosphere continuum. Multivariate data assimilation refers to the simultaneous assimilation of observation data from multiple model state variables into a simulation model. In recent years, several land data assimilation systems have been developed in different research agencies. Because of the software availability or adaptability, these systems are not easy to apply for the purpose of multivariate land data assimilation research. We developed an open source multivariate land data assimilation framework (DasPy) which is implemented using the Python script language mixed with the C++ and Fortran programming languages. LETKF (Local Ensemble Transform Kalman Filter) is implemented as the main data assimilation algorithm, and uncertainties in the data assimilation can be introduced by perturbed atmospheric forcing data, and represented by perturbed soil and vegetation parameters and model initial conditions. The Community Land Model (CLM) was integrated as the model operator. The implementation allows also parameter estimation (soil properties and/or leaf area index) on the basis of the joint state and parameter estimation approach. The Community Microwave Emission Modelling platform (CMEM), COsmic-ray Soil Moisture Interaction Code (COSMIC) and the Two-Source Formulation (TSF) were integrated as observation operators for the assimilation of L-band passive microwave, cosmic-ray soil moisture probe and land surface temperature measurements, respectively. DasPy has been evaluated in several assimilation studies of neutron count intensity (soil moisture), L-band brightness temperature and land surface temperature. DasPy is parallelized using the hybrid Message Passing Interface and Open Multi-Processing techniques. All the input and output data flows are organized efficiently

  14. Alterations in the immunohistochemical expression of Das-1 and CG-3 in colonic mucosal biopsy specimens helps distinguish ulcerative colitis from Crohn disease and from other forms of colitis.

    PubMed

    Yantiss, Rhonda K; Das, Kiron M; Farraye, Francis A; Odze, Robert D

    2008-06-01

    Distinction between ulcerative colitis (UC) and Crohn disease (CD) in mucosal biopsies is often difficult. Das-1 and CG-3 are monoclonal antibodies directed against an unknown colonic epithelial protein and human tropomyosin isoform-5, respectively, both show altered expression in patients with UC. In this study, we evaluated the utility of Das-1 and CG-3 in distinguishing UC from CD and from other types of colitis. One colonic biopsy specimen from each of 85 patients with confirmed UC (n=25), CD (n=15), lymphocytic (n=15), collagenous (n=15), and ischemic (n=15) colitis, and also 10 samples from normal controls, were stained for Das-1 and CG-3 using standard techniques. Reactivity for Das-1 and CG-3 was noted to be absent or present, and the location (ie, surface+/-crypt epithelium) and degree (weak or strong) of CG-3 staining was recorded. Loss of Das-1 staining occurred more frequently in UC (96%) compared with CD (20%), lymphocytic (20%), collagenous (13%), and ischemic colitis (0%) cases, as well as controls (10%, P<0.001 for all comparisons). CG-3 positivity in crypt epithelium was significantly more common in UC (52%) compared with the other groups (P< or =0.02 for all comparisons). The combination of strong crypt CG-3 staining and loss of Das-1 staining was noted in 44% of UC cases, but not in any other type of colitis (P=0.003 for all comparisons). We conclude that the patterns of Das-1 and CG-3 staining in colonic mucosal biopsies may be clinically useful in distinguishing UC from CD and from other colitidies.

  15. Agronomic performance of insect-protected and herbicide-tolerant MON 89034 × TC1507 × NK603 × DAS-40278-9 corn is equivalent to that of conventional corn.

    PubMed

    Cerqueira, Denise T Rezende de; Schafer, Ariane C; Fast, Brandon J; Herman, Rod A

    2017-03-31

    Agronomic characteristics of genetically modified (GM) MON 89034 × TC1507 × NK603 × DAS-40278-9 (PowerCore™ Enlist™), MON 89034 × TC1507 × NK603 (PowerCore™), and DAS-40278-9 (Enlist™) corn, a non-GM near-isogenic hybrid, and two commercial non-GM hybrids were assessed in a field study to determine if the agronomic performance of the GM corn hybrids is equivalent to that of non-transgenic hybrid corn. The MON 89034 × TC1507 × NK603 × DAS-40278-9 hybrid corn was developed through stacking of four individual transgenic events, MON 89034, TC1507, NK603, and DAS-40278-9 by traditional breeding and contains the cry1A.105 and cry2Ab2 (MON 89034), cry1F and pat (TC1507), cp4 epsps (NK603) and aad-1 (DAS-40278-9) transgenes. These transgenes encode the proteins Cry1A.105, Cry2Ab2, and Cry1F, which confer insect resistance, PAT, CP4 EPSPS, and AAD-1, which confer herbicide tolerance. The following agronomic characteristics were assessed in the study: initial and final stand count, seedling vigor, time to silk, time to pollen shed, pollen viability, plant height, ear height, stalk lodging, root lodging, days to maturity, stay green, disease incidence, insect damage, herbicide injury, and yield. The agronomic assessment was conducted in two regions of Brazil (Indianopolis-MG; Cravinhos-SP). The agronomic attributes for all GM entries were statistically indistinguishable from the non-GM near-isogenic hybrid. In addition, most of the agronomic assessments fell within the range of the commercial varieties included in the study. Taken together, MON 89034 × TC1507 × NK603 × DAS-40278, MON 89034 × TC1507 × NK603, and DAS-40278-9 were found to be agronomically equivalent to non-GM corn.

  16. Metabolism and Residues of 2,4-Dichlorophenoxyacetic Acid in DAS-40278-9 Maize (Zea mays) Transformed with Aryloxyalkanoate Dioxygenase-1 Gene.

    PubMed

    Zhou, Xiao; Rotondaro, Sandra L; Ma, Mingming; Rosser, Steve W; Olberding, Ed L; Wendelburg, Brian M; Adelfinskaya, Yelena A; Balcer, Jesse L; Blewett, T Craig; Clements, Bruce

    2016-10-12

    DAS-40278-9 maize, which is developed by Dow AgroSciences, has been genetically modified to express the aryloxyalkanoate dioxygenase-1 (AAD-1) protein and is tolerant to phenoxy auxin herbicides, such as 2,4-dichlorophenoxyacetic acid (2,4-D). To understand the metabolic route and residue distribution of 2,4-D in DAS-40278-9 maize, a metabolism study was conducted with (14)C-radiolabeled 2,4-D applied at the maximum seasonal rate. Plants were grown in boxes outdoors. Forage and mature grain, cobs, and stover were collected for analysis. The metabolism study showed that 2,4-D was metabolized to 2,4-dichlorophenol (2,4-DCP), which was then rapidly conjugated with glucose. Field-scale residue studies with 2,4-D applied at the maximum seasonal rate were conducted at 25 sites in the U.S. and Canada to measure the residues of 2,4-D and free and conjugated 2,4-DCP in mature forage, grain, and stover. Residues of 2,4-D were not detectable in the majority of the grain samples and averaged <1.0 and <1.5 μg/g in forage and stover, respectively. Free plus conjugated 2,4-DCP was not observed in grain and averaged <1.0 μg/g in forage and stover.

  17. Development of multiplex PCR method for simultaneous detection of four events of genetically modified maize: DAS-59122-7, MIR604, MON863 and MON88017.

    PubMed

    Oguchi, Taichi; Onishi, Mari; Mano, Junichi; Akiyama, Hiroshi; Teshima, Reiko; Futo, Satoshi; Furui, Satoshi; Kitta, Kazumi

    2010-01-01

    A novel multiplex PCR method was developed for simultaneous event-specific detection of four events of GM maize, i.e., DAS-59122-7, MIR604, MON88017, and MON863. The single laboratory examination of analytical performance using simulated DNA mixtures containing GM DNA at various concentrations in non-GM DNA suggested that the limits of detection (LOD) of the multiplex PCR method were 0.16% for MON863, MIR604, and MON88017, and 0.078% for DAS-59122-7. We previously developed a nonaplex (9plex) PCR method for eight events of GM maize, i.e., Bt11, Bt176, GA21, MON810, MON863, NK603, T25, and TC1507. Together with the nonaplex PCR method, the newly developed method enabled the detection and identification of eleven GM maize events that are frequently included in commercial GM seed used in Japan. In addition, this combinational analysis may be useful for the identification of combined event products of GM maize.

  18. Brazil's premier gold province. Part I: The tectonic, magmatic, and structural setting of the Archean Rio das Velhas greenstone belt, Quadrilátero Ferrífero

    NASA Astrophysics Data System (ADS)

    Lobato, Lydia; Ribeiro-Rodrigues, Luiz; Zucchetti, Márcia; Noce, Carlos; Baltazar, Orivaldo; da Silva, Luiz; Pinto, Claiton

    2001-07-01

    Rocks of the Rio das Velhas Supergroup comprise one of the most significant Archean greenstone-belt successions in Brazil, in both their appreciable mineral productivity and extensive mineral potential. A large part of this greenstone belt is contained within the Quadrilátero Ferrífero (Iron Quadrangle) region, Minas Gerais state, southeastern Brazil, which occupies the southernmost portion of the São Francisco craton. The Nova Lima Group rocks, at the base of the Rio das Velhas greenstone belt, host important orogenic gold deposits. The group contains lithological associations from bottom to top as follows: (1) mafic-ultramafic volcanic, (2) volcanic-chemical, (3) clastic-chemical, (4) volcaniclastic, and (5) resedimented rocks. Rocks of the resedimented, volcanic-chemical, and mafic-ultramafic volcanic associations mainly host the most important gold deposits. An early compressional deformation occurs in the rocks of the Rio das Velhas greenstone belt and basement gneisses, with tangential thrusting from the north to the south or southwest. Structures generated during a second, compressional deformation, encompass NW-striking thrust faults and SW-vergent, tight to isoclinal folds, inferring a general southwest transport direction. In the central portion of the Quadrilátero Ferrífero, the Paciência lineament, which strikes northwest and dips to the northeast in the south, or strikes northeast and dips to the southeast in the north, is a thrust-related, oblique ramp fault that hosts important gold deposits. The convergence of these two trends in the Nova Lima region is accommodated by roughly E-W-striking transcurrent faults, which are the most favored sites for large gold concentrations. Intracratonic extension in Late Archean to early Paleoproterozoic times and NW-vergent, Trans-Amazonian compressional deformation post-date gold deposition. Late extension during the Paleoproterozoic led to basin formation and the prominent dome-and-keel architecture of the

  19. Feeling Normal? Long-Term Follow-up of Patients with a Cleft Lip-Palate after Rhinoplasty with the Derriford Appearance Scale (DAS-59).

    PubMed

    Albers, Andreas E; Reichelt, Andreas C; Nolst-Trenité, Gilbert J; Menger, Dirk Jan

    2016-04-01

    The stigma of nasal deformity due to a congenital cleft lip-palate has an undeniable influence on the affected patient's life. It is therefore of interest to investigate if efforts to reduce esthetic and functional impairments by rhinoplasty (single or multiple) can result in an increased satisfaction with appearance and a self-perception similar to the noncleft population. Retrospective scoring before and after rhinoplasty using the validated Derriford Appearance Scale (DAS-59) and subsequent statistical evaluation and comparison to datasets available in the literature for further classification was used. Of the 61 patients who underwent at least one rhinoplasty, 26 responded to all questions. The mean age of responders was approximately 30 years of age and the male:female ratio was 1:1.2. The scale showed a significant overall improvement after surgery. The full scale and all subscale scores of the DAS-59 were significantly reduced after surgery demonstrating an improvement in the respective categories. Most importantly, if postoperative results were compared with a population concerned and unconcerned about appearance, no difference "facial self-consciousness" of appearance was apparent. Also postoperative subscores for "general self-consciousness" (GSC) and "social self-consciousness" of appearance (SSC) showed no difference from those obtained from the population concerned about appearance. The postoperative subscore for "sexual and bodily self-consciousness" of appearance (SBSC) indicated improvement beyond the level found in the concerned control population. Due to only a low improvement in the difference compared with the subscore representing a "negative self-concept," a statistically significant difference to the concerned population remained, possibly indicating that therapy beyond surgery is needed for improvement. After rhinoplasty, the investigated group of cleft lip-palate patients with nasal deformities showed an improvement in their self

  20. Registry of Hospital Das Clínicas of the University of São Paulo Medical School: First Official Solid Organ and Tissue Transplantation Report – 2008

    PubMed Central

    Azeka, Estela; Auler Júnior, José Otavio Costa; Fernandes, Paulo Manuel Pego; Nahas, Willian Carlos; Fiorelli, Alfredo Inácio; Tannuri, Uenis; Cristofani, Lílian Maria; Caiero, Marcelo Tadeu; Dulley, Frederico Luiz; de Oliveira Paggiaro, André; Bacchella, Telesforo

    2009-01-01

    OBJECTIVE: The aim of this study was to report a single center experience of organ and tissue transplantation INTRODUCTION: This is the first report of organ and tissue transplantation at the Hospital das Clínicas of the University of Sao Paulo Medical School. METHODS: We collected data from each type of organ transplantation from 2002 to 2007. The data collected were patient characteristics and actuarial survival Kaplan-Meier curves at 30 days, one year, and five years RESULTS: There were a total of 3,321 transplants at our institution and the 5-year survival curve ranged from 53% to 88%. CONCLUSION: This report shows that solid organ and tissue transplants are feasible within the institution and allow us to expect that the quality of transplantation will improve in the future. PMID:19219318

  1. Short-term monitoring of a gas seep field in the Katakolo bay (Western Greece) using Raman spectra DTS and DAS fibre-optic methods

    NASA Astrophysics Data System (ADS)

    Chalari, A.; Mondanos, M.; Finfer, D.; Christodoulou, D.; Kordella, S.; Papatheodorou, G.; Geraga, M.; Ferentinos, G.

    2012-12-01

    A wide submarine seep of thermogenic gas in the Katakolo bay, Western Greece, was monitored passively using the intelligent Distributed Acoustic Sensor (iDAS) and Ultima Raman spectra Distributed Temperature Sensor (DTS), in order to study the thermal and noise signal of the bubble plumes released from the seafloor. Katakolo is one one of the most prolific thermogenic gas seepage zones in Europe and the biggest methane seep ever reported in Greece. Very detailed repetitive offshore gas surveys, including marine remote sensing (sub-bottom profiling, side scan sonar), underwater exploration by a towed instrumented system (MEDUSA), long-term monitoring benthic station (GMM), compositional and isotopic analyses, and flux measurements of gas, showed that: (a) gas seepage takes place over an extended area in the Katakolo harbour and along two main normal faults off the harbour; (b) at least 823 gas bubble ( 10-20 cm in diameter) plumes escaping over an area of 94,200 m2, at depths ranging from 5.5 to 16 m; (c) the gas consists mainly of methane and has H2S levels of hundreds to thousands ppmv, and shows significant amounts of other light hydrocarbons like ethane, propane, iso-butane and C6 alkanes, (d) offshore and onshore seeps release the same type of thermogenic gas; (e) due to the shallow depth, more than 90 % of CH4 released at the seabed enters the atmosphere, and (f) the gas seeps may produce severe geohazards for people, buildings and construction facilities due to the explosive and toxicological properties of methane and hydrogen sulfide, respectively. For the short-term monitoring, the deployment took place on a site located inside the harbour of Katakolo within a thermogenic gas seepage area where active faults are intersected. The iDAS system makes it possible to observe the acoustical signal along the entire length of an unmodified optical cable without introducing any form of point sensors such as Bragg gratings. When the bubble plumes are released by the

  2. Dating human occupation at Toca do Serrote das Moendas, São Raimundo Nonato, Piauí-Brasil by electron spin resonance and optically stimulated luminescence.

    PubMed

    Kinoshita, Angela; Skinner, Anne R; Guidon, Niede; Ignacio, Elaine; Felice, Gisele Daltrini; Buco, Cristiane de A; Tatumi, Sonia; Yee, Márcio; Figueiredo, Ana Maria Graciano; Baffa, Oswaldo

    2014-12-01

    Excavation of Toca do Serrote das Moendas, in Piauí state, Brazil revealed a great quantity of fossil wild fauna associated with human remains. In particular, fossils of a cervid (Blastocerus dichotomus) were found, an animal frequently pictured in ancient rock wall paintings. In a well-defined stratum, two loose teeth of this species were found in close proximity to human bones. The teeth were independently dated by electron spin resonance (ESR) in two laboratories. The ages obtained for the teeth were 29 ± 3 ka (thousands of years) and 24 ± 1 ka. The concretion layer capping this stratum was dated by optically stimulated luminescence (OSL) of the quartz grains to 21 ± 3 ka. As these values were derived independently in three different laboratories, using different methods and equipment, these results are compelling evidence of early habitation in this area.

  3. Application of a Fibre Optic Distributed Acoustic Sensor (DAS) for Shallow Seismic Investigations of a Fractured Dolostone Aquifer in Guelph, Ontario.

    NASA Astrophysics Data System (ADS)

    Munn, J. D.; Parker, B. L.; Coleman, T. I.; Mondanos, M.; Chalari, A.

    2014-12-01

    Understanding groundwater flow and contaminant transport in fractured bedrock aquifers requires detailed characterization of the discrete features that control flow, as well as the properties of the rock matrix. This requires multiple, high-resolution, depth discrete datasets that provide different, but complementary information. Distributed fibre optic sensing is a relatively new technology used to continuously monitor properties along the entire length of an optical fibre. Technological advances over the past few years have brought the sensitivity and spatial resolution to the point where shallow (<200m) borehole applications are practicable. Recent studies using fibre optic distributed temperature sensors (DTS) have shown excellent application of DTS for characterizing groundwater flow in both continuously sealed and open boreholes. This presentation highlights the results of a field trial at the Bedrock Aquifer Research Station on the University of Guelph campus (Ontario, Canada) where a single fibre optic cable was interrogated by both a DTS (Ultima-DTS) and a Distributed Acoustic Sensor (iDAS). DAS is a relatively recent development that allows an optical fibre to be used as a receiver for seismic imaging. These seismic images are produced by sending an optical pulse down the fibre and analyzing the effects of seismic waves on the propagating light. Numerous vertical seismic profiles were collected and the effects of different fibre optic cable structures and coupling techniques were examined. The seismic profiles will help delineate structural features and lithological contacts away from the borehole wall, and will assist in correlating other geophysical, hydraulic, or geological logs collected in the boreholes across the site. Preliminary results show promise for shallow seismic imaging and continued field trials will allow refinement of the technique.

  4. Simultaneous functions of the installed DAS/DAK formaldehyde-assimilation pathway and the original formaldehyde metabolic pathways enhance the ability of transgenic geranium to purify gaseous formaldehyde polluted environment.

    PubMed

    Zhou, Shengen; Xiao, Sunqin; Xuan, Xiuxia; Sun, Zhen; Li, Kunzhi; Chen, Limei

    2015-04-01

    The overexpression of dihydroxyacetone synthase (DAS) and dihydroxyacetone kinase (DAK) from methylotrophic yeasts in chloroplasts created a photosynthetic formaldehyde (HCHO)-assimilation pathway (DAS/DAK pathway) in transgenic tobacco. Geranium has abilities to absorb and metabolize HCHO. Results of this study showed that the installed DAS/DAK pathway functioning in chloroplasts greatly enhanced the role of the Calvin cycle in transgenic geranium under high concentrations of gaseous HCHO stress. Consequently, the yield of sugars from HCHO-assimilation increased approximately 6-fold in transgenic geranium leaves, and concomitantly, the role of three original HCHO metabolic pathways reduced, leading to a significant decrease in formic acid, citrate and glycine production from HCHO metabolism. Although the role of three metabolic pathways reduced in transgenic plants under high concentrations of gaseous HCHO stress, the installed DAS/DAK pathway could still function together with the original HCHO metabolic pathways. Consequently, the gaseous HCHO-resistance of transgenic plants was significantly improved, and the generation of H2O2 in the transgenic geranium leaves was significantly less than that in the wild type (WT) leaves. Under environmental-polluted gaseous HCHO stress for a long duration, the stomata conductance of transgenic plants remained approximately 2-fold higher than that of the WT, thereby increasing its ability to purify gaseous HCHO polluted environment.

  5. Further evidence of 777 Ma subduction-related continental arc magmatism in Eastern Dom Feliciano Belt, southern Brazil: The Chácara das Pedras Orthogneiss

    NASA Astrophysics Data System (ADS)

    Koester, E.; Porcher, C. C.; Pimentel, M. M.; Fernandes, L. A. D.; Vignol-Lelarge, M. L.; Oliveira, L. D.; Ramos, R. C.

    2016-07-01

    In this study new SHRIMP U-Pb zircon data for the Chácara das Pedras Gneiss in Porto Alegre, southern Brazil are presented. They represent a small exposure of the crust which was intruded by a large volume of orogenic to anorogenic granitoids at ca. 618-562 m.y. in the Eastern Domain of the Dom Feliciano Belt. The Chácara das Pedras tonalitic orthogneiss has geochemical similarities with subduction-related magmatic rocks of continental arcs. They present high Sr initial ratios (∼0.712), negative ɛNd(t = 777) values (∼-6), TDM varying from 1.8 to 2.0 Ga. The igneous protoliths of these orthogneisses were previously considered to be Paleoproterozoic based on an upper intercept age of discordant zircon analyses. In the present study these orthogneisses were re-sampled and re-analyzed in an attempt to obtain more concordant analytical data. The U-Pb zircon analyses were carried out using the SHRIMP IIe at the Laboratório de Geocronologia de Alta Resolução of the Universidade de São Paulo. The U-Pb concordia age obtained for igneous textural domains of the zircon grains is 777 ± 4 Ma. A few analyses on zircon overgrowths give poorly defined late Cryogenian ages of ca. 650 Ma. Older ages, mostly discordant, were obtained in a few zircon cores, showing an upper intercept age of ca. 1.9 Ga. One sample of the Três Figueiras Granodiorite, which crosscut the orthogneiss in the same outcrop, was also investigated. The zircons of this granodiorite are, however, mostly metamitic, preventing the determination of a reliable age. Some concordant analyses from a few grains define ages ranging in the interval between ca. 603 and 1022 Ma. The youngest (ca. 603 Ma) may represent a maximum age for the granodiorite crystallization. Older ages, with discordance <10%, are of 745, 777, 836 and 1022 Ma. The 777 ± 4 Ma age obtained for the Chácara das Pedras orthogneiss is the first Early Cryogenian magmatic age determined for granitoids in the Porto Alegre region, although

  6. Massa do gás e das estrelas em aglomerados: eficiência da formação estelar

    NASA Astrophysics Data System (ADS)

    Laganá, T. F.; Lima Neto, G. B.

    2003-08-01

    Os aglomerados de galáxias apresentam um interesse especial para a cosmologia observacional. Eles são as maiores estruturas ligadas pela gravitação no Universo e relaxadas na região central. A comparação entre a massa do gás intra-aglomerado (responsável por ~25% da massa total, inferida a partir de observações em raios-X), a massa contida nas estrelas (i.e., nas galáxias) e a massa total (incluindo a matéria escura não bariônica), nos dá informações importantes sobre os processos de formação e evolução de aglomerados. Por exemplo, a razão entre a massa do gás e a massa total é uma medida da fração de bárions no Universo (razão entre a matéria bariônica e matéria escura) e, utilizando a densidade de bárions predita pela nucleosíntese primordial, podemos deduzir a densidade de matéria escura no Universo (cf. White et al. 1993). O objetivo deste trabalho é obter as razões entre as massas do gás, estelar (contida nas galáxias), e a total (massa dinâmica). As massas do gás e total são obtidas a partir das análises fotométrica e espectroscópica em raios-X enquanto que a massa estelar é obtida pela análise fotométrica das galáxias. Esta análise foi aplicada ao aglomerado Abell 496 observado pelo satélite XMM-Newton. A massa contida nas galáxias foi estimada a partir da função de luminosidade obtida por Durret et al. (2002). Para determinar as massas dinâmica e do gás nos precisamos determinar os perfis radiais de densidade e temperatura. Nós apresentaremos aqui estes resultados e suas implicações na eficiência da formação estelar em Abell 496.

  7. [Nutritional status of patients with breast cancer attended in the Mastology Service of Belo Horizonte's Hospital das Clínicas in the state of Minas Gerais, Brazil].

    PubMed

    de Oliveira, Dirce Ribeiro; Carvalho, Erika Simone Coelho; Campos, Liliane Cunha; Leal, José Adalberto; Sampaio, Estela Viana; Cassali, Geovanni Dantas

    2014-05-01

    The scope of this article is to evaluate the nutritional status, body composition and tumor characteristics of 31 patients with breast cancer attended at the Mastology Service of Hospital das Clínicas of the Federal University of Minas Gerais. Dietary data were obtained from the 24-hour dietary recall in the pre-operative state and analyzed by the DietWin Professional 2008 Nutrition Software. Body composition was assessed by bioelectrical impedance analysis. The tumor characterization data were collected from medical records. The mean age of patients was 50.75 ± 14.34 years. Excess body weight was found in 58% and waist circumference greater than 80 cm in 64.5% of patients Excessive consumption of oils and sugars was observed in 90.3% and 83.8%, respectively. Most had low intakes of calcium and vitamins B6, B12 and A. The predominant diagnosis was type II histological grade invasive ductal carcinoma in stage II or III. The prevalence of overweight and inadequate dietary intake demonstrate the need for individualized nutritional guidance and monitoring to improve the prognosis and quality of the life of patients.

  8. [Travelers' vaccinations: experience from the Travelers' Clinic of Hospital das Clínicas, University of São Paulo School of Medicine].

    PubMed

    Chinwa Lo, Simone; Mascheretti, Melissa; Chaves, Tânia do Socorro Souza; Lopes, Marta Heloisa

    2008-01-01

    The profile and vaccination status of travelers seeking pre-travel medical advice at the Travelers' Clinic of Hospital das Clínicas, University of São Paulo School of Medicine, and the vaccines recommended for them, were analyzed in the present study. Among the 445 travelers who were studied, 51% were women, the median age was 33.5 years, 51% were traveling on business and 39.5% were traveling for leisure purposes. The destinations most sought were Africa (47%), Asia (31.7%) and South America (21.4%). Vaccination before traveling was recommended for 385 (86.5%) of the travelers. The main vaccines recommended were against typhoid fever (55.7%), diphtheria-tetanus (54.1%), hepatitis A (46.1%), hepatitis B (44.2%) and yellow fever (24.7%). The pre-travel guidance was shown to be important not only for indicating the vaccines recommended for the trip, but also as an opportunity to update routine vaccinations.

  9. Dating of fossil human teeth and shells from Toca do Enoque site at Serra das Confusões National Park, Brazil.

    PubMed

    Kinoshita, Angela; Sullasi, Henry L; Asfora, Viviane K; Azevedo, Renata L; Guzzo, Pedro; Guidon, Niede; Figueiredo, Ana Maria G; Khoury, Helen; Pessis, Anne-Marie; Baffa, Oswaldo

    2016-06-07

    This work reports the dating of a fossil human tooth and shell found at the archaeological site Toca do Enoque located in Serra das Confusões National Park (Piauí, Brazil). Many prehistoric paintings have been found at this site. An archaeological excavation unearthed three sepulchers with human skeletons and some shells. Two Brazilian laboratories, in Ribeirão Preto (USP) and Recife (UFPE), independently performed Electron Spin Resonance (ESR) measurements to date the tooth and the shell and obtain the equivalent dose received by each sample. The laboratories determined similar ages for the tooth and the shell (~4.8 kyBP). The results agreed with C-14 dating of the shell and other samples (charcoal) collected in the same sepulcher. Therefore, this work provides a valid inter-comparison of results by two independent ESR-dating laboratories and between two dating methods; i.e., C-14 and ESR, showing the validity of ESR dating for this range of ages.

  10. [Voice disorder clinic in the speech therapy outpatient unit at "Hospital das Clínicas da Universidade Federal de Minas Gerais"].

    PubMed

    Menezes, Letícia Neiva de; Behlau, Mara; Gama, Ana Cristina Côrtes; Teixeira, Letícia Caldas

    2011-07-01

    This study set out to describe the profile of the patients with voice complaints and/or alterations who were attended between July 2003 and December 2006 at the speech therapy outpatient unit of "Hospital das Clínicas da Universidade Federal de Minas Gerais." This was analyzed according to age, sex, profession, schooling, origin, treatment performed and factors that interfere in medical care evolution. This was a retrospective study based on the analysis of the recorded data of the individuals according to a specifically prepared Protocol. The results showed that the individuals included in this study were predominantly young women, referred by a specialist from Belo Horizonte, who do not work and also have incomplete elementary school education. Attendance of those patients was on an individual basis, and almost half of them were discharged by the speech therapist. The elderly patients, who have functional or psychogenic dysphonia and a neutral or wheezy type of voice, showed a close correlation with the discharge rate by speech therapist. The younger individuals with organo-functional dysphonia bore a statistical correlation with abandoning treatment. The individuals who eventually abandoned treatment did not bear any correlation with the crossed variables.

  11. Cometas: Das Lendas aos Fatos

    NASA Astrophysics Data System (ADS)

    Voelzke, M. R.

    O descobrimento de cometas, devido ao seu aparecimento espetacular, tem registro nas mais antigas culturas humanas. A primeira referência situa-se no ano de 1095 antes de Cristo [a.C.; HO; HO, 1962]. A quantidade de registros de descobrimentos cometários, principalmente provenientes do território chinês em particular e do oriente em geral, aumentou gradualmente a partir do quarto século depois de Cristo (d.C.). É de origem chinesa a primeira referência ao cometa P/Halley no ano de 240 a.C. [VOELZKE, 1993]. Com o desenvolvimento da astronomia relativamente às técnicas observacionais os descobrimentos bem como as observações cometárias aumentaram sensivelmente a partir do século XVII, sendo que a partir do século XIX um novo incremento ocorreu devido ao emprego da fotografia e a resultante melhora de sensibilidade na observação.

  12. The geology of the Morro Velho gold deposit in the Archean Rio das Velhas greenstone belt, Quadrilátero Ferrífero, Brazil

    USGS Publications Warehouse

    Vial, Diogenes Scipioni; DeWitt, Ed; Lobato, Lydia Maria; Thorman, Charles H.

    2007-01-01

    The Morro Velho gold deposit, Quadrilátero Ferrífero region, Minas Gerais, Brazil, is hosted by rocks at the base of the Archean Rio das Velhas greenstone belt. The deposit occurs within a thick carbonaceous phyllite package, containing intercalations of felsic and intermediate volcaniclastic rocks and dolomites. Considering the temporal and spatial association of the deposit with the Rio das Velhas orogeny, and location in close proximity to a major NNW-trending fault zone, it can be classified as an orogenic gold deposit. Hydrothermal activity was characterized by intense enrichment in alteration zones of carbonates, sulfides, chlorite, white mica±biotite, albite and quartz, as described in other Archean lode-type gold ores. Two types of ore occur in the deposit: dark gray quartz veins and sulfide-rich gold orebodies. The sulfide-rich orebodies range from disseminated concentrations of sulfide minerals to massive sulfide bodies. The sulfide assemblage comprises (by volume), on average, 74% pyrrhotite, 17% arsenopyrite, 8% pyrite and 1% chalcopyrite. The orebodies have a long axis parallel to the local stretching lineation, with continuity down the plunge of fold axis for at least 4.8 km. The group of rocks hosting the Morro Velho gold mineralization is locally referred to as lapa seca. These were isoclinally folded and metamorphosed prior to gold mineralization. The lapa seca and the orebodies it hosts are distributed in five main tight folds related to F1 (the best examples are the X, Main and South orebodies, in level 25), which are disrupted by NE- to E-striking shear zones. Textural features indicate that the sulfide mineralization postdated regional peak metamorphism, and that the massive sulfide ore has subsequently been neither metamorphosed nor deformed. Lead isotope ratios indicate a model age of 2.82 ± 0.05 Ga for both sulfide and gold mineralization. The lapa seca are interpreted as the results of a pre-gold alteration process and may be

  13. Guidelines on management of human infection with the novel virus influenza A (H1N1)--a report from the Hospital das Clínicas of the University of São Paulo.

    PubMed

    Hajjar, Ludhmila Abrahao; Schout, Denise; Galas, Filomena Regina Barbosa Gomes; Uip, David Everson; Levin, Anna Sara Shafferman; Caiaffa Filho, Helio Hehl; Sakane, Pedro Takanori; Suslik, Carlos Alberto; Teixeira, Jose Manoel de Camargo; Bonfa, Eloisa; Barone, Antonio Alci; Martins, Milton de Arruda; Boulos, Marcos; Auler, Jose Otavio Costa

    2009-01-01

    The pandemic novel influenza A (H1N1) infection was considered widespread in Brazil on July, 2009. Since then, 9.249 cases were confirmed in Brazil, most of them concentrated in São Paulo. The Hospital das Clínicas of the University of São Paulo is a reference center for H1N1 cases in São Paulo. The purpose of this review is to analyze the evidence concerning diagnosis, prevention, and treatment of novel influenza A (H1N1) infection. In addition, we propose guidelines for the management of this pandemic emphasizing Hospital das Clínicas "bundles" for the control of the pandemic novel influenza A (H1N1).

  14. Using the DAS-ELISA Test to Establish an Effective Distance Between Bait Stations for Control of Linepithema humile (Hymenoptera: Formicidae) in Natural Areas.

    PubMed

    Song, Jinbo; Benson, Eric P; Zungoli, Patricia A; Gerard, Patrick; Scott, Simon W

    2015-08-01

    Linepithema humile (Mayr), the Argentine ant, is an invasive pest that has spread throughout the United States and is a problem in natural and managed habitats in South Carolina. Foraging patterns and the effectiveness of liquid baits for control of this pest have been studied in urban areas. However, similar studies have not been conducted in natural areas such as parks, picnic grounds, or campsites. L. humile populations can be large and widespread, making them a major nuisance pest for visitors to these natural areas. The primary objective of this study was to determine an effective distance between bait stations for control of L. humile in a natural area. A double antibody-sandwich enzyme-linked immunosorbent assay (DAS-ELISA) procedure was used to detect individual ants that consumed rabbit immunoglobin (IgG) protein for marking and tracking. In both lab and field conditions, there was a significant difference in the detection of IgG in ants fed protein marker mixed with sugar water compared with ants only fed sugar water. Additional field studies revealed that an individual ant could retain detectable levels of protein marker for 3 d and that an ant feeding on IgG containing bait could be detected over 15 m from the original bait source. Overall, we found that using liquid ant baits, with a placement of 20 m between stations, was effective in reducing L. humile numbers between April to October, 2012 in a natural park area of Lake Greenwood State Park, SC.

  15. Brazil's premier gold province. Part II: geology and genesis of gold deposits in the Archean Rio das Velhas greenstone belt, Quadrilátero Ferrífero

    NASA Astrophysics Data System (ADS)

    Lobato, Lydia; Ribeiro-Rodrigues, Luiz; Vieira, Frederico

    2001-07-01

    Orogenic, gold deposits are hosted by rocks of the Archean Rio das Velhas greenstone belt in the Quadrilátero Ferrífero region, Minas Gerais state, Brazil, one of the major gold provinces in the world. The gold deposits occur at the base of the mafic-ultramafic succession, with the most important orebodies controlled by E-W-striking, strike-slip faults. The main mineralization styles are (1) structurally controlled, sulfide replacement zones in banded iron formation (BIF); (2) disseminated sulfide minerals and gold in hydrothermally altered rocks along shear zones; and (3) auriferous quartz-carbonate-sulfide veins and veinlets in mafic, ultramafic, and felsic volcanic rocks, and also in clastic sedimentary rocks. The most common host rocks for ore are metamorphosed oxide- and carbonate-facies banded iron (± iron-rich metachert) formations (e.g., the Cuiabá, São Bento and Raposos deposits) and the lapa seca unit, which is a local term for intensely carbonatized rock (e.g., the giant Morro Velho mine with >450 t of contained gold). Metabasalts host most of the remaining gold deposits. Mineralogical characteristics and fluid inclusion studies suggest variations in the H2O/CO2 ratio of a low-salinity, near-neutral, reducing, sulfur-bearing, ore fluid. The presence of abundant CH4-rich inclusions is related to reduction of the original H2O-CO2 fluid via interaction with carbonaceous matter in the wallrocks. Oxygen fugacity was close to that of graphite saturation, with variations likely to have been influenced by reaction with the carbonaceous matter. Carbon-rich phyllites and schists, which commonly bound ore-bearing horizons, seem to have played both a physical and chemical role in localizing hydrothermal mineral deposition. Microtextural studies indicate that gold deposition was mainly related to desulfidation reactions, and was paragenetically coeval with precipitation of arsenic-rich iron sulfide minerals. Carbon isotope data are compatible with dissolution of

  16. Epidemiology of human infection with the novel virus influenza A (H1N1) in the Hospital das Clínicas, São Paulo, Brazil--June-September 2009.

    PubMed

    Schout, Denise; Hajjar, Ludhmila Abrahao; Galas, Filomena Regina Barbosa Gomes; Uip, David Everson; Levin, Anna Sara Shafferman; Caiaffa Filho, Helio Hehl; Sakane, Pedro Takanori; Suslik, Carlos Alberto; Teixeira, Jose Manoel de Camargo; Bonfa, Eloisa; Barone, Antonio Alci; Martins, Milton de Arruda; Boulos, Marcos; Auler, Jose Otavio Costa

    2009-01-01

    The pandemic novel influenza A (H1N1) infection was considered widespread in Brazil on July 16, 2009. Since then, 46,810 cases of acute respiratory syndrome have been reported in Brazil, most of them concentrated in São Paulo. Through September 16, we have confirmed 9,249 cases of novel influenza A H1N1in Brazil, including 699 deaths. The mortality rate observed in Brazil is 0.47/100,000 inhabitants and varies according to region. In this period, São Paulo registered 3733 cases (40.3% of the total) of novel influenza A (H1N1) infection and 327 deaths, reflecting a mortality rate of 0.79/100,000 inhabitants. The Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC) is a reference center for H1N1 cases in São Paulo. During the winter of 2009, 472 patients in this hospital were diagnosed with H1N1 infection; of these, 210 were admitted, and 16 died. To control this pandemic and to provide adequate care for these patients, the Hospital das Clínicas implemented "bundles" including prevention strategies, an epidemiologic surveillance service, availability of fast diagnosis, antiviral treatment and training of staff. The purpose of this manuscript is to describe the epidemiologic features of novel human influenza A (H1N1) infection in the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo during the winter period of the 2009 pandemic.

  17. Método numérico das diferenças finitas no domínio do tempo aplicado a ondas Alfvén em plasma astrofísico

    NASA Astrophysics Data System (ADS)

    Dos Santos, L. C.; Kintopp, J. A.; Jatenco-Pereira, V.; Opher, R.

    2003-08-01

    Ondas Alfvén em plasma astrofísico têm sido objeto de intenso estudo nas últimas décadas pelo fato de apresentarem papel importante em muitas áreas de pesquisa na astrofísica. Particularmente são importantes no mecanismo de aquecimento da coroa solar; em ventos estelares; em jatos galácticos e extragalácticos; em discos protoestelares, etc. A formulação para diferenças finitas no domínio do tempo (FDTD), aplicada a plasma magnetizado é desenvolvida para estudo das propriedades de ondas Alfvén em três dimensões (3D-FDTD). O método é aplicado inicialmente a um plasma homogêneo e isotérmico imerso em uma região com campo magnético externo B0, que sofre uma pequena perturbação. Uma vez gerada a onda, esta perturbação é retirada e, então analisamos a evolução temporal das ondas, bem como a forma de seu amortecimento.

  18. Vernetztes Lernen: Eine Unterrichtseinheit mit Heinrich von Kleists Erzahlung "Das Erdbeben in Chili" und Crista Wolfs Roman "Kein Ort. Nirgends" (Networked Learning: An Instructional Unit with Heinrich von Kleist's Story "The Earthquake in Chile" and Christa Wolf's Novel "No Place, No Where").

    ERIC Educational Resources Information Center

    Eidecker, Martina Elisabeth

    1999-01-01

    Presents an instructional model, using Kleist's story "Das Erdbeben in Chili" and Christa Wolf's novel Kei Ort. Nirgends" as a basis. The model clearly distinguishes itself from quantitative models and mediates solid literary knowledge through an inductive approach. Learning takes place in a multidimensional space that makes possible multiple…

  19. Mapping health assessment questionnaire disability index (HAQ-DI) score, pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) onto the EuroQol-5D (EQ-5D) utility score with the KORean Observational study Network for Arthritis (KORONA) registry data.

    PubMed

    Kim, Hye-Lin; Kim, Dam; Jang, Eun Jin; Lee, Min-Young; Song, Hyun Jin; Park, Sun-Young; Cho, Soo-Kyung; Sung, Yoon-Kyoung; Choi, Chan-Bum; Won, Soyoung; Bang, So-Young; Cha, Hoon-Suk; Choe, Jung-Yoon; Chung, Won Tae; Hong, Seung-Jae; Jun, Jae-Bum; Kim, Jinseok; Kim, Seong-Kyu; Kim, Tae-Hwan; Kim, Tae-Jong; Koh, Eunmi; Lee, Hwajeong; Lee, Hye-Soon; Lee, Jisoo; Lee, Shin-Seok; Lee, Sung Won; Park, Sung-Hoon; Shim, Seung-Cheol; Yoo, Dae-Hyun; Yoon, Bo Young; Bae, Sang-Cheol; Lee, Eui-Kyung

    2016-04-01

    The aim of this study was to estimate the mapping model for EuroQol-5D (EQ-5D) utility values using the health assessment questionnaire disability index (HAQ-DI), pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) in a large, nationwide cohort of rheumatoid arthritis (RA) patients in Korea. The KORean Observational study Network for Arthritis (KORONA) registry data on 3557 patients with RA were used. Data were randomly divided into a modeling set (80 % of the data) and a validation set (20 % of the data). The ordinary least squares (OLS), Tobit, and two-part model methods were employed to construct a model to map to the EQ-5D index. Using a combination of HAQ-DI, pain VAS, and DAS28, four model versions were examined. To evaluate the predictive accuracy of the models, the root-mean-square error (RMSE) and mean absolute error (MAE) were calculated using the validation dataset. A model that included HAQ-DI, pain VAS, and DAS28 produced the highest adjusted R (2) as well as the lowest Akaike information criterion, RMSE, and MAE, regardless of the statistical methods used in modeling set. The mapping equation of the OLS method is given as EQ-5D = 0.95-0.21 × HAQ-DI-0.24 × pain VAS/100-0.01 × DAS28 (adjusted R (2) = 57.6 %, RMSE = 0.1654 and MAE = 0.1222). Also in the validation set, the RMSE and MAE were shown to be the smallest. The model with HAQ-DI, pain VAS, and DAS28 showed the best performance, and this mapping model enabled the estimation of an EQ-5D value for RA patients in whom utility values have not been measured.

  20. Association between rheumatoid arthritis disease activity, progression of functional limitation and long-term risk of orthopaedic surgery: combined analysis of two prospective cohorts supports EULAR treat to target DAS thresholds

    PubMed Central

    Nikiphorou, Elena; Norton, Sam; Young, Adam; Carpenter, Lewis; Dixey, Josh; Walsh, David Andrew; Kiely, Patrick

    2016-01-01

    Objectives To examine the association between disease activity in early rheumatoid arthritis (RA), functional limitation and long-term orthopaedic episodes. Methods Health Assessment Questionnaire (HAQ) disability scores were collected from two longitudinal early RA inception cohorts in routine care; Early Rheumatoid Arthritis Study and Early Rheumatoid Arthritis Network from 1986 to 2012. The incidence of major and intermediate orthopaedic surgical episodes over 25 years was collected from national data sets. Disease activity was categorised by mean disease activity score (DAS28) annually between years 1 and 5; remission (RDAS≤2.6), low (LDAS>2.6–3.2), low-moderate (LMDAS≥3.2–4.19), high-moderate (HMDAS 4.2–5.1) and high (HDAS>5.1). Results Data from 2045 patients were analysed. Patients in RDAS showed no HAQ progression over 5 years, whereas there was a significant relationship between rising DAS28 category and HAQ at 1 year, and the rate of HAQ progression between years 1 and 5. During 27 986 person-years follow-up, 392 intermediate and 591 major surgeries were observed. Compared with the RDAS category, there was a significantly increased cumulative incidence of intermediate surgery in HDAS (OR 2.59 CI 1.49 to 4.52) and HMDAS (OR 1.8 CI 1.05 to 3.11) categories, and for major surgery in HDAS (OR 2.48 CI 1.5 to 4.11), HMDAS (OR 2.16 CI 1.32 to 3.52) and LMDAS (OR 2.07 CI 1.28 to 3.33) categories. There was no significant difference in HAQ progression or orthopaedic episodes between RDAS and LDAS categories. Conclusions There is an association between disease activity and both poor function and long-term orthopaedic episodes. This illustrates the far from benign consequences of persistent moderate disease activity, and supports European League Against Rheumatism treat to target recommendations to secure low disease activity or remission in all patients. PMID:26979104

  1. Cometa Hyakutake (C/1996 B2): análise do gás e características físicas das partículas de poeira

    NASA Astrophysics Data System (ADS)

    Sanzovo, G. C.; de Almeida, A. A.; Boczko, R.

    2003-08-01

    A completa caracterização e compreensão do núcleo de um cometa novo é de fundamental importância para a elucidação dos processos físicos e químicos atuantes na época da formação do Sistema Solar. O Cometa Hyakutake, conjuntamente com o Cometa Hale-Bopp representam os objetos mais brilhantes que visitaram o Sistema Solar Interno nos últimos 20 anos. Neste Trabalho, nós aplicamos o Método Semi-Empírico das Magnitudes Visuais (MSEMV) à aproximadamente 4000 dados observacionais que correlacionam a magnitude visual absoluta com a distância heliocêntrica para o Cometa Hyakutake nas fases pré- e pós-periélicas. Como produto da aplicação desse método, conseguimos caracterizar dimensionalmente seu núcleo e área ativa efetiva. As taxas de produção dos radicais CN, C2 e C3, obtidos a partir de dados disponíveis na literatura, revelam que, além de muito brilhante, o Hyakutake é um cometa "normal" no sentido de Cochran (1986). Desse modo, deduzimos as taxas de perdas de água (em moléculas/s) a partir da análise de sua magnitude visual aparente, e as convertemos em taxas de perdas de gás (em g/s), despreendido pelo nucleo cometário. Com o auxílio do modelo fotométrico clássico da poeira, realizamos uma análise sistemática e uniforme dessa componente cometária, a partir dos fluxos observacionais no contínuo, para os comprimentos de onda 365,0 e 484,5 nm, assumindo que esses fluxos são o resultado da radiação solar espalhada por grãos de partículas micrométricos presentes na coma. Com isso, pudemos obter as taxas de produção (em g/s), cores (relativas à cor neutra solar), e as dimensões efetivas médias das partículas de poeira, bem como as razões poeira-gás.

  2. Composition of grain and forage from insect-protected and herbicide-tolerant corn, MON 89034 × TC1507 × MON 88017 × DAS-59122-7 (SmartStax), is equivalent to that of conventional corn (Zea mays L.).

    PubMed

    Lundry, Denise R; Burns, J Austin; Nemeth, Margaret A; Riordan, Susan G

    2013-02-27

    Monsanto Company and Dow AgroSciences LLC have developed the combined-trait corn product MON 89034 × TC1507 × MON 88017 × DAS-59122-7 (SmartStax, a registered trademark of Monsanto Technology LLC). The combination of four biotechnology-derived events into a single corn product (stacking) through conventional breeding provides broad protection against lepidopteran and corn rootworm insect pests as well as tolerance to the glyphosate and glufosinate-ammonium herbicide families. The purpose of the work described here was to assess whether the nutrient, antinutrient, and secondary metabolite levels in grain and forage tissues of the combined-trait product are comparable to those in conventional corn. Compositional analyses were conducted on grain and forage from SmartStax, a near-isogenic conventional corn hybrid (XE6001), and 14 conventional reference hybrids, grown at multiple locations across the United States. No statistically significant differences between SmartStax and conventional corn were observed for the 8 components analyzed in forage and for 46 of the 52 components analyzed in grain. The six significant differences observed in grain components (p < 0.05) were assessed in context of the natural variability for that component. These results demonstrate that the stacked product, SmartStax, produced through conventional breeding of four single-event products containing eight proteins, is compositionally equivalent to conventional corn, as previously demonstrated for the single-event products.

  3. Lactic acid microbiota identification in water, raw milk, endogenous starter culture, and fresh Minas artisanal cheese from the Campo das Vertentes region of Brazil during the dry and rainy seasons.

    PubMed

    Castro, R D; Oliveira, L G; Sant'Anna, F M; Luiz, L M P; Sandes, S H C; Silva, C I F; Silva, A M; Nunes, A C; Penna, C F A M; Souza, M R

    2016-08-01

    Minas artisanal cheese, produced in the Campo das Vertentes region of Brazil, is made from raw milk and endogenous starter cultures. Although this cheese is of great historical and socioeconomic importance, little information is available about its microbiological and physical-chemical qualities, or about its beneficial microbiota. This work was aimed at evaluating the qualities of the cheese and the components used for its production, comparing samples collected during the dry and rainy seasons. We also conducted molecular identification and isolated 50 samples of lactic acid bacteria from cheese (n=21), water (n=3), raw milk (n=9), and endogenous starter culture (n=17). The microbiological quality of the cheese, water, raw milk, and endogenous starter culture was lower during the rainy period, given the higher counts of coagulase-positive Staphylococcus and total and thermotolerant coliforms. Enterococcus faecalis was the lactic acid bacteria isolated most frequently (42.86%) in cheese samples, followed by Lactococcus lactis (28.57%) and Lactobacillus plantarum (14.29%). Lactobacillus brevis (5.88%), Enterococcus pseudoavium (5.88%), Enterococcus durans (5.88%), and Aerococcus viridans (5.88%) were isolated from endogenous starter cultures and are described for the first time in the literature. The lactic acid bacteria identified in the analyzed cheeses may inhibit undesirable microbiota and contribute to the safety and flavor of the cheese, but this needs to be evaluated in future research.

  4. Physikgeschichte Das Rätsel bleibt

    NASA Astrophysics Data System (ADS)

    Hoffmann, Dieter

    2002-05-01

    Die jüngst erfolgte Veröffentlichung von Dokumenten aus dem Privatarchiv der Familie Bohr [1] über den geheimnisumwitterten Besuch von Werner Heisenberg in Kopenhagen im September 1941 hat in den deutschen Medien große Resonanz gefunden [2]. Tatsächlich verraten uns die jetzt veröffentlichten Dokumente sehr viel mehr über die Zeit ihres Entstehens als über den Besuch selbst.

  5. Internationale Schulreformtendenzen und das Problem der Lehrerausbildung

    NASA Astrophysics Data System (ADS)

    Kupisiewicz, Czeslaw

    1982-09-01

    The main theme of this article is that the socio-economic and educational changes which have occurred in industrialized countries in the past 20 to 25 years necessitate a thorough reform of the present system of teacher education. The first group of such changes includes the information explosion, greater occupational mobility, the growing significance and increasing role of the sciences, the development of the mass media, higher educational aspirations, technical development, the acceleration of the psycho-physical development of children and youth, and the injurious effects of the uncontrolled development of the constantly changing civilisation (deterioration of the human environment, diseases caused by the effects of civilisation, etc.). In the face of these changes, teachers must not remain indifferent and teacher education systems have to take them into account. Within the second group of changes influencing the content and methods of teacher education, the most important is the generalisation of education at the pre-school, primary and secondary school levels and also at the university level. As a result, education in many types of school and at ever higher levels has lost the elitist character it still had, not so long ago, and has become a mass activity. This has considerably affected teachers' work and, necessarily, also the work of the teacher education systems. In present-day schools it is necessary to emphasize not only the transmission of knowledge of the `know that' type, as was done in the past, but also problem-solving, independent individual and group work, etc., which will enable children and young people to acquire `know-how' and `know-why'. This must also be reflected in teacher education. In order to adapt the teacher education systems to the requirements of the changing society, a reform of the goals, contents and methods of the system will have to be prepared and implemented as a prerequisite and starting point for a global reform of the entire education system.

  6. Das deutsche Adverbialsystem (The German Adverbial System)

    ERIC Educational Resources Information Center

    Droescher, W. O.

    1974-01-01

    Describes the surface structure of German adverbs proceeding from the standpoint of dependence-valence grammar. On the basis of their meaning, adverbs are classified as modal, temporal and locational. (Text is in German.) (IFS/WGA)

  7. Kanban - der Weg ist das Ziel

    NASA Astrophysics Data System (ADS)

    Aull, Florian; Berlak, Joachim; Dickmann, Eva; Dickmann, Philipp; Fischäder, Holm; Gerlach, Joachim; Henneberg, Jens; Kapalla, Klaus; Kress, Oliver; Kuttler, Robert; Schneider, Herfried M.; Schürle, Philipp; Stellpflug, Franz-Josef; Wannenwetsch, Ralph; Wulz, Johannes; Zäh, Michael F.

    Wenn man aktuell Produktionsbereiche in Deutschland und Europa besucht, fallen im Zusammenhang mit modernen Produktionsmethoden immer öfter die Begriffe Kanban (jap. Karte, Signal) und Pull-Produktion, und dies nicht ohne Stolz, da diese mit dem schillernden Vorbild des Toyota Produktionssystems in Zusammenhang stehen. Tatsächlich ist Kanban ein integraler Bestandteil moderner Produktionssysteme. Blickt man aber im Rahmen von Prozessanalysen hinter die Fassaden", d. h. in die tägliche Praxis der Arbeitsprozesse, wird man schnell desillusioniert - die viel gepriesenen klassischen Kanban-Regeln werden im Tagesgeschäft nicht eingehalten.

  8. Das Gluck des Kindes (The Child's Happiness).

    ERIC Educational Resources Information Center

    Fuhr, Thomas

    2002-01-01

    Examines the pedagogical discourse on the child's happiness, the structure of happiness, empirical findings on a child's happiness. Addresses the problems of research on children's needs. Concludes that happiness also includes feelings of joy or sorrow and that pedagogical judgments should take into account these feelings. (CAJ)

  9. Das Gluck des Lehrers (The Teacher's Happiness).

    ERIC Educational Resources Information Center

    Higgins, Christopher

    2002-01-01

    Argues that the ethics of teaching concerns the relationship between the teaching and the good life. Uses Bernard Williams' ethics/morality distinction. Connects the question of "why teach?" with the question "how should I live?" Asks why the practice of teaching is worth it in terms of self growth and monetary gains. (CAJ)

  10. Rotação do jato em DG tau próximo à região de sua formação: análise comparativa das velocidades radiais simuladas e observadas

    NASA Astrophysics Data System (ADS)

    Cerqueira, A. H.; de Gouveia dal Pino, E. M.

    2003-08-01

    Os modelos magneto-centrífugos utilizados para explicar a formação dos jatos Herbig-Haro assumem a presença de um disco de acresção em rotação kepleriana na base de lançamento do jato. Neste cenário, o jato transmite a informação da rotação do disco para regiões distantes da fonte central, além da superfície de Alfvén, na região de colimação inicial do jato. Recentemente, Bacciotti et al. (2002, ApJ, 537, L49) obtiveram pela primeira vez uma evidência observacional de rotação em um jato HH, o jato em DG Tau, em regiões próximas da fonte central, compatível (qualitativa e quantitativamente) com o esperado a partir dos modelos magneto-centrífugos para a produção e colimação inicial de jatos HH. No presente trabalho, apresentamos mapas de velocidade radial, obtidos através de simulações numéricas tri-dimensionais SPH, para um jato com características semelhantes ao jato em DG Tau, objetivando uma comparação com os mapas de velocidade radiais obtidos por Bacciotti et al.. Nossos resultados, embora preliminares, indicam que a inclusão de efeitos como a precessão, evidenciada em DG Tau (Dougados et al. 2000, A&A, 357, L61) devem ser levadas em consideração na análise da presença de rotação não só em DG Tau mas em qualquer sistema, com o uso das velocidades radias observadas. A ausência de um grau elevado de simetria axial (quebrada, por exemplo, pela precessão do eixo do jato; ou pela presença de uma superfície interna de trabalho, ou seja, um bow shock interno), implica também em uma maior complexidade nos mapas, com conseqüências relevantes para suas interpretações.

  11. Performance of lactating dairy cows fed corn as whole plant silage and grain produced from genetically modified corn containing event DAS-59122-7 compared to a nontransgenic, near-isogenic control.

    PubMed

    Brouk, M J; Cvetkovic, B; Rice, D W; Smith, B L; Hinds, M A; Owens, F N; Iiams, C; Sauber, T E

    2011-04-01

    The nutritional equivalency of grain plus whole plant silage from genetically modified corn plants containing the DAS-59122-7 (59122) event expressing the Cry34Ab1 and Cry35Ab1 proteins to grain and silage from a near-isogenic corn hybrid without this trait (control) was assessed using lactating dairy cows. Corn plants with event 59122 are resistant to western corn rootworm and tolerant to the herbicide active ingredient glufosinate-ammonium. Effects on feed intake, milk production, and milk composition were determined. The 59122 grain and the control grain were produced in 2005 from isolated plots in Richland, Iowa. Whole plant corn silage for the 59122 and control treatments were grown in isolated plots at the Kansas State University Dairy Center and ensiled in Ag-Bags. Thirty lactating Holstein cows blocked by lactation number, day of lactation, and previous energy-corrected milk production were used in a switchback design. All cows were fed diets that contained 22.7% grain plus 21.3% whole plant silage from either the 59122 or the control hybrid, in addition to 21% wet corn gluten feed, 12.3% protein mix, 8.0% whole cottonseed, and 14.7% alfalfa hay. Each period of the switchback trial included 2 wk for diet adjustment followed by 4 wk for data and sample collection. Milk samples (a.m. and p.m.) collected from 2 consecutive milkings of each collection wk were analyzed for fat, protein, lactose, solids-not-fat, milk urea nitrogen, and somatic cell count. Percentages of milk fat, protein, lactose, and solids-not-fat were not affected by dietary treatment. Yields of milk, 4% fat-corrected milk, energy-corrected milk, solids-corrected milk, and the concentrations and yields of milk fat, milk protein, milk solids, and milk lactose were not significantly different between treatments. Efficiencies of milk, fat-corrected milk, energy-corrected milk, and solids-corrected milk production also were not different when cows were fed crops from 59122 than when they were fed

  12. Importance of land use update during the calibration period and simulation of water balance response to land use change in the upper Rio das Mortes Catchment (Cerrado Biome, Central-Western Brazil)

    NASA Astrophysics Data System (ADS)

    Lamparter, Gabriele; Kovacs, Kristof; Nobrega, Rodolfo; Gerold, Gerhard

    2015-04-01

    Changes in the hydrological balance and following degradation of the water ecosystem services due to large scale land use changes are reported from agricultural frontiers all over the world. Traditionally, hydrological models including vegetation and land use as a part of the hydrological cycle use a fixed distribution of land use for the calibration period. We believe that a meaningful calibration - especially when investigating the effects of land use change on hydrology - demands the inclusion of land use change during the calibration period into the calibration procedure. The SWAT (Soil and Water Assessment Tool) model is a process-based, semi-distributed model calculating the different components of the water balance. The model bases on the definition of hydrological response units (HRUs) which are based on soil, vegetation and slope distribution. It specifically emphasises the role of land use and land management on the water balance. The Central-Western region of Brazil is one of the leading agricultural frontiers, which experienced rapid and radical deforestation and agricultural intensification in the last 40 years (from natural Cerrado savannah to cattle grazing to intensive corn and soya cropland). The land use history of the upper Rio das Mortes catchment (with 17500 km²) is reasonably well documented since the 1970th. At the same time there are almost continuous climate and runoff data available for the period between 1988 and 2011. Therefore, the work presented here shows the model calibration and validation of the SWAT model with the land use update function for three different periods (1988 to 1998, 1998 to 2007 and 2007 to 2011) in comparison with the same calibration periods using a steady state land use distribution. The use of the land use update function allows a clearer identification which changes in the discharge are due to climatic variability and which are due to changes in the vegetation cover. With land use update included into the

  13. Determinação da massa de júpiter a partir das órbitas de seus satélites: um experimento didático

    NASA Astrophysics Data System (ADS)

    Schlickmann, M. S.; Saito, R. K.; Becker, D. A.; Rezende, M. F., Jr.; Cid Fernandes, R.

    2003-08-01

    Este trabalho apresenta o roteiro piloto de uma prática observacional em astronomia, junto com os primeiros resultados obtidos nesta fase de implementacão. O projeto, que será executado em duas etapas, visa introduzir noções de Astronomia a alunos do Ensino Médio e iniciantes nos cursos de Física. O experimento consiste em medir as órbitas dos satélites Galileanos e, a partir da análise dos dados coletados, verificar a validade da Lei das órbitas de Kepler, determinando a massa do planeta Júpiter. Em uma primeira etapa, as observações serão feitas utilizando um telescópio Meade LX200 10" e câmera CCD para obter uma seqüência de imagens do planeta, que possibilitará medir o movimento de seus satélites. A segunda etapa terá início a partir do funcionamento do telescópio em modo robótico, com a possibilidade de observações via internet por instituições de ensino. Para o desenvolvimento deste experimento foram inicialmente coletadas várias imagens de Júpiter obtidas com os instrumentos citados acima. Estas imagens serviram como base para confecção dos roteiros para a experiência no nível médio e superior. Os roteiros serão inicialmente apresentados em uma home-page. Nela também se buscará uma contextualização histórica da experiência bem como o estabelecimento de relações com professores e alunos, propostas metodológicas e a disponibilização dos programas computacionais necessários para a utilização "on-line" pelos usuários. O projeto conta com apoio da Fundação VITAE.

  14. Endovascular Treatment of Aortic Aneurysms and Blood Transfusion. What do We Need?

    PubMed

    Machado, Rui; Loureiro, Luís; Antunes, Inês; Coutinho, Jorge; Almeida, Rui

    2016-05-01

    Introdução: O tratamento endovascular dos aneurismas da aorta reduziu as taxas de transfusão. Não existem recomendações relativamente às unidades de glóbulos vermelhos a serem tipadas por crossmatch pré-operatoriamente. O nosso objetivo é contribuir para a análise das unidades de glóbulos vermelhos necessárias no tratamento endovascular dos aneurismas da aorta e na cirurgia híbrida de aneurismas da aorta e definir um protocolo do Maximum Surgical Blood Orders Schedule. Material e Métodos: Analisámos retrospetivamente a base de dados prospectiva dos doentes tratados eletivamente por tratamento endovascular dos aneurismas da aorta, entre 2001 e 2012. Analisamos idade, género, classe ASA, Maximum Surgical Blood Orders Schedule, unidades de glóbulos vermelhos transfundidas e tempos, endoprótese, relação unidades de glóbulos vermelhos consumidas/endoprótese, relação unidades crossmatched/transfundidas, conversão para cirurgia convencional, hemoglobina pré-operatória e na alta. Resultados: Selecionamos para análise 187 doentes, 90% homens, idade média 73,1, classe ASA III mais frequente. Usamos próteses aorto-bi-iliaca em 71%, aorto-uni-iliaca 23% e torácica 6%. Não necessitaram transfusão 72,6%. Transfundimos 171 unidades de glóbulos vermelhos. A relação unidades crossmatched/transfundidas foi 10,1 até 2010 e 7,3 após. A relação unidades de glóbulos vermelhos consumidas/endoprótese nas primeiras 24 horas foi 0,21 unidades de glóbulos vermelhos/aorto-bi-iliaca, 0,46 unidades de glóbulos vermelhos/aorto-uni-iliaca, 0,8 unidades de glóbulos vermelhos/torácica, 1,3 unidades de glóbulos vermelhos/híbrida-torácica e duas unidades de glóbulos vermelhos/híbrida-aorto-bi-iliaca. Obtivemos relação estatisticamente significativa entre unidades de glóbulos vermelhos transfundidas/endoprótese (p < 0,001) e entre classificação ASA e unidades de glóbulos vermelhos transfundidas após 24 h (p < 0,01). Discussão: As recomenda

  15. Unidad: Las influencias culturales en el arte mexicana (Unit: Cultural Influences in Mexican Art). Dos semanas.

    ERIC Educational Resources Information Center

    Finere, Neal

    This two-week unit, appropriate for bilingual education settings as well as foreign language programs, deals with the three primary cultural influences found in Mexican contemporary art. The multisensory materials, pragmatic focus, and direct creative student involvement are designed to make it a microcosmic, real-life experience. The first part…

  16. Screening for pulmonary tuberculosis in Teresópolis, RJ, Brazil: the search for respiratory symptomatic patients in emergency service of "Hospital das Clínicas de Teresópolis Costantino Ottaviano, Fundação Educacional Serra dos Orgãos".

    PubMed

    Siqueira-Batista, Rodrigo; Gomes, Andréia Patrícia; Bisaglia, Joana B; Borlot, Paulo Estevão W; D'avila Junior, Heraldo X; Faria, Carolina Gonçalves P P de; Braga, Bernardo D; Bezerra, Tiago S; Cedrola, Juan Pedro V; Almeida, Guilherme C; Couto, Lílian S; Nacif, Marcelo; Crivano, Elvira

    2005-01-01

    The aim of the present study was to investigate the detection percentage of tuberculosis among patients that are respiratory symptomatic (TB suspects). In this work, we present the preliminary results of research carried out at "Hospital das Clínicas de Teresópolis Costantino Ottaviano da Fundacao Educacional Serra dos Orgãos (FESO)" from November 2003 to April 2004. Among the 40 respiratory symptomatic individuals identified and referred to the Tuberculosis Control Program in Teresópolis , two (5.0%) were characterized as smear-positive. These results confirm reports in the literature and underscore the need for and importance of this strategy.

  17. [Teaching human anatomy to the graduation course in Health Sciences of the Lisbon University: five years of a new educational experience].

    PubMed

    Furtado, Ivo A; Gonçalves Ferreira, Ana D; Gonçalves Ferreira, António J

    2013-01-01

    Introdução/Objectivos: Os autores fazem o balanço dos primeiros cinco anos de ensino de Anatomia da Licenciatura em Ciências da Saúde da Universidade de Lisboa.Material e Métodos: Estudaram o desempenho de 408 alunos inscritos na Unidade Curricular de Anatomia (disciplina obrigatória do primeiro semestre) e 29 na Unidade Curricular de Neuroanatomia (disciplina opcional do sexto semestre). Realizaram a análise estatística pelos testes Anova e t de Student.Resultados e Discussão: Houve um afluxo crescente anual de alunos inscritos na Unidade Curricular de Anatomia, um número estável em Neuroanatomia, predomínio claro de alunos do sexo feminino, ratio docente/aluno variável entre 1/9 e 1/17 na Unidade Curricular de Anatomia e 1/8 na Unidade Curricular de Neuroanatomia; elevado número de desistências iniciais (15,69%) em Anatomia; níveis de aprovação de 95,93% na Unidade Curricular de Anatomia e de 100% em Neuroanatomia; tendência de melhoria verificada nos últimos dois anos, com significado estatístico na Unidade Curricular de Anatomia (p = 0,0001) e igual desempenho escolar de alunos de ambos os sexos; índices de satisfação dos alunos de Anatomia, Bom = 71% e Muito Bom = 8%; Neuroanatomia, classificaçãounânime pelos alunos = Muito Bom.Conclusões: Foi uma experiência pedagógica muito positiva. Os autores propõem: o estudo e a prevenção das causas da desistência inicial dos alunos que acedem ao curso, melhoria do ratio docente/discente, possível extensão a um segundo semestre da Unidade Curricular de Anatomia e melhoria das instalações que já estão em curso e que inclui a remodelação e a modernização do teatro anatómico do Instituto de Anatomia da Faculdade de Medicina da Universidade de Lisboa.

  18. Proving the Orbits of the Galilean Moons Through Astrophotography. (Spanish Title: Comprobando Las Órbitas de Las Lunas Galileanas a Través de la Astrofotografía.) Evidenciando as Órbitas das Luas Galileanas Atravéd da Astrofotografia

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo

    2009-12-01

    An activity related to the observation of the Galilean moons and to amateur astrophotography is presented in this work. Through the reading of excerpts of the book Sidereus Nuncius (Sidereal Messenger), by Galileo, it is possible to trace a methodology to observe the planet and its natural satellites and, with the aid of the astrophotography, to analyze the field recordings. Moreover, it is possible to compare the images obtained after plotting the relative positions of these moons to prove their orbits. This activity can be conducted by teachers, students and amateur astronomers, in order to develop their capabilities of observation of astronomical phenomena. Se presenta en este trabajo una actividad relacionada a la observación de las lunas Galileanas y a la astrofotografía amateur. A través de la lectura de tramos de la obra Sidereus Nuncius (El Mensajero Sideral) de Galileo, es posible trazar una metodología para la observación del planeta y de sus satélites naturales y, con el auxilio de la astrofotografía, analizar las anotaciones de campo. Además, es posible comparar las imágenes obtenidas con el gráfico de las posiciones relativas de estas lunas para comprobar sus órbitas. Esa actividad puede ser realizada por maestros, estudiantes y astrónomos amateurs, de forma a desarrollar sus capacidades de observación de los fenómenos astronómicos. Uma atividade relacionada à observação das luas Galileanas e à astrofotografia amadora é apresentada neste trabalho. Através da leitura de trechos da obra Sidereus Nuncius (Mensageiro Sideral), de Galileu, é possível traçar uma metodologia para a observação do planeta e de seus satélites naturais e, com o auxílio da astrofotografia, analisar as anotações de campo. Além disso, é possível comparar as imagens obtidas com o gráfico das posições relativas destas luas para evidenciar suas órbitas. Essa atividade pode ser realizada por professores, estudantes e astrônomos amadores, de forma a

  19. Coordinator(a) de Servicios Clinicos. Parte I (Unidad I-IV). Parte II (Unidad V-VI). Guia. Documento de Trabajo (Clinical Services Coordinator. Part I. Units I-IV. Part II. Units V-VI. Guide. Working Document).

    ERIC Educational Resources Information Center

    Puerto Rico State Dept. of Education, Hato Rey. Area for Vocational and Technical Education.

    This guide is intended for instructing secondary students in the occupation of clinical services coordinator in a hospital. The first part contains four units on the following subjects: the occupation of clinical services coordinator; interpersonal relationships; ethical/legal aspects; and communications (telephone, intercom, and others). For each…

  20. [Threshold value of f/Vt index for predicting successful weaning from mechanical ventilation in active smokers].

    PubMed

    Rivas-Salazar, Rommel Jesús; Baltazar-Torres, José Ángel; Arvizu-Tachiquín, Perla Cristina; Moreno-López, Israel; Zamora-Varela, Sergio; Cano-Oviedo, Abraham Antonio; Esquivel-Chávez, Alejandro; Sánchez-Hurtado, Luis Alejandro

    2016-01-01

    Introducción: la ventilación mecánica (VM) se utiliza en el 60-70 % de los ingresos a la unidad de cuidados intensivos (UCI). Un valor umbral del índice f/Vt de 105 es un predictor de éxito en el retiro de la ventilación mecánica (RVM) en pacientes con asma, cirugía cardiaca, neumonía, sepsis, neurocríticos, etc. Sin embargo, no existen reportes de la utilidad del índice f/Vt para predecir RVM exitoso en pacientes con tabaquismo activo (TA). El objetivo de este trabajo es identificar un valor umbral del índice f/Vt para predecir RVM exitoso en pacientes con TA. Métodos: se incluyeron prospectivamente 85 pacientes con TA y VM >24 horas, ingresados a la UCI. Se registraron variables demográficas y clínicas. Se midió el índice f/Vt con un espirómetro de Wright y se calculó su sensibilidad, especificidad, valor predictivo positivo (VPP) y valor predictivo negativo (VPN) para predecir RVM exitoso. Una p <0.05 se consideró estadísticamente significativa. Resultados: el promedio del índice f/Vt fue de 68.69. El RVM exitoso fue del 75.3 %. Un valor umbral del índice f/Vt de 79.5 tuvo sensibilidad de 76 %, especificidad de 61 %, VPP de 85 % y VPN de 46 % para predecir RVM exitoso en este grupo de enfermos. Conclusiones: el valor umbral del índice f/Vt de 79.5 es útil para predecir éxito en el RVM en pacientes con TA.

  1. Escaparate. Programa de lectura y ensenanza del lenguaje, Unidad C (Show Window. Reading and Language Learning Program, Unit C).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    Stories in Spanish about aspects of the history, culture, and daily life of Mexican Americans are included in this reading book developed by Edgewood School District Bilingual Program in San Antonio, Texas, for students in grade four through secondary school. "Escaparate" is the third of eight units being developed in this reading and language…

  2. Erfolgsfaktoren von Lehrstellenmarketing in der dualen berufsbildung: das beispiel Schweiz

    NASA Astrophysics Data System (ADS)

    Sager, Fritz

    2006-09-01

    SUCCESS FACTORS OF APPRENTICESHIP MARKETING IN A SYSTEM OF DUAL VOCATIONAL TRAINING: THE CASE OF SWITZERLAND - The dual system of vocational training, utilizing both company training and vocational school, is generally acknowledged to be a successful model, but a decreasing number of trainee posts in Switzerland poses a crisis for the approach. One strategy for overcoming the problem involves offering incentives for companies to create new trainee posts. The present study explores the necessary conditions for successfully influencing the number of trainee posts through apprenticeship marketing. A comparision of qualitative case studies of six marketing projects demonstrates that while context, in the sense of basic structural conditions and political sensibility for the problematic, plays a role in the success of a project, what is central is above all the form of the trainee-post marketing project itself. This has to do with the behaviour of the actors involved as well as the choice of the mode of governance and project organization. The latter has to do with making available requisite technical and personal resources, coordination on the part of the project direction, and giving those responsible the necessary room to act in implementing the project.

  3. Der Forschungsflughafen und das Institut fuer Luft- und Raumfahrtsysteme

    DTIC Science & Technology

    2007-11-02

    Broitzem: Deutsche Verkehrsfliegerschule Völkenrode: Deutsche Forschungsanstalt für Luftfahrt (DFL) Waggum: Technische Hochschule Grundsteinlegung...Forschungsflughafen Aerodata Deutsches Zentrum für Luft- und Raumfahrt DLR VW Air Services TU Braunschweig Luftfahrt -Bundesamt LBA Deutscher Aeroclub

  4. Excising das All: Evolving Maxwell waves beyond Scri

    NASA Technical Reports Server (NTRS)

    vanMeter, James R.; Fiske, David R.; Misner, Charles W.

    2006-01-01

    We study the numerical propagation of waves through future null infinity in a conformally compactified spacetime. We introduce an artificial cosmological constant, which allows us some control over the causal structure near null infinity. We exploit this freedom to ensure that all light cones are tilted outward in a region near null infinity, which allows us to impose excision-style boundary conditions in our finite difference code. In this preliminary study we consider electromagnetic waves propagating in a static, conformally compactified spacetime.

  5. Identifizierung der Eintragsquellen von Antibiotika in das Grundwasser viehstarker Regionen

    NASA Astrophysics Data System (ADS)

    Hannappel, Stephan; Köpp, Claudia; Zühlke, Sebastian; Balzer, Frederike; Schulz, Dietrich

    2016-11-01

    Only few sulfonamide antibiotics were detected in near-surface groundwater in areas with a high stocking rate in northwestern Germany. Intensive sampling with a high resolution in time and space was applied in order to illuminate the findings. As some pharmaceuticals can be of both human and animal origin, they may enter the environment via application of manure/digestate to arable land or via domestic waste water. In addition to existing monitoring wells, non-permanent wells were sampled to obtain information regarding pathways into the ground water. Interviews with farmers and chemical analyses show that application of manure leads to low concentrations (<100 ng/l) of Sulfadimidin and Sulfadiazin in most of the investigated samples. Sulfamethoxazol was found above 100 ng/l and likely originated from sewage of nearby small scale wastewater treatment plants. Sulfamethoxazole and its main metabolite could be detected within the plants; additionally, the sewage tracer acesulfam-K was detected in the groundwater.

  6. Demokratie lernen am gymnasium: das projekt "schule als staat"

    NASA Astrophysics Data System (ADS)

    Sajak, Clauß Peter

    2002-09-01

    (Learning Democracy in High School: the "School as State" Project) - The disquieting social developments in the German Federal Republic are leading to intense discussions about the possibilities of instilling values and democratic attitudes within the context of secondary education. The interdisciplinary educational project "School as State" has been running for some time in various schools in Baden-Württemberg. This article describes the goals and processes of this project and examines the didactic approaches from which it emerged.

  7. Das Deutschlandspiegelvideo (The View-of-Germany-Videos).

    ERIC Educational Resources Information Center

    Pentecost, Gislind E.

    1993-01-01

    Describes View-of-Germany-Videos, published by the Goethe Institute. The videos are authentic, entertaining, and very versatile in usefulness. In addition they are short, thus easily incorporated into a lesson plan, and free of charge, making them accessible to any educational establishment. (AB)

  8. Das andere Zuhause. Ortsbezüge hochqualifizierter Migranten

    NASA Astrophysics Data System (ADS)

    Plöger, Jörg; Günther, Florian

    2016-12-01

    Cities are increasingly addressing high-skilled migrants. Our contribution examines the factors that shape how this group relates to places and why cities provide different conditions for this. We draw on empirical data from an explorative case study with highly qualified migrants in the university city of Münster. First, we look at the place ties at the new place of residence and thereby focus on their local social networks and their sense of belonging. Second, we turn to the place-specific characteristics, in particular the role of "connections" and "urban opportunity structures". Based on our findings we discuss how urban policy-making may influence the place attachment of this desired group.

  9. Astronomy in High School: Using a Mini-Planetarium to Understand Details of the Apparent Movement of Stars. (Spanish Title: Astronomía en la Escuela Secundaria: Comprendiendo los Detalles del Movimiento Aparente de Las Estrellas con un Miniplanetario.) Astronomia no Ensino Médio: Compreendendo Detalhes do Movimento Aparente das Estrelas com um Miniplanetário

    NASA Astrophysics Data System (ADS)

    dos Santos Leão, Demetrius

    2013-07-01

    en la comprensión de estas cuestiones y demostraron un gran interés por esta metodología. O objetivo deste artigo é apresentar parte dos resultados obtidos com a intervenção feita como projeto da dissertação de mestrado do autor, que consistiu no desenvolvimento de um conjunto de aulas de Astronomia, com alunos do 1º Ano do Ensino Médio de uma escola da rede privada do Distrito Federal (Brasília, Brasil), empregando como recurso principal um material didático chamado miniplanetário (MP). Utilizando como pressuposto teórico norteador dessas aulas as ideias de contextualização e dialogicidade de Paulo Freire, foi proposta aos estudantes a montagem e utilização desse recurso em uma sessão de planetário. Durante o projeto, enfatizaram-se assuntos como a trajetória aparente das estrelas para o céu de Brasília, a localização dos pontos cardeais a partir da constelação do Cruzeiro do Sul, as cores das estrelas e as estrelas vistas de uma determinada localidade. Apurou-se que os alunos apresentaram melhoria na compreensão desses assuntos, bem como demonstraram expressiva empolgação com essa metodologia desenvolvida.

  10. High School Student's Alternative Conceptions About the Phenomenon of the Formation of the Moon Phases. (Spanish Title: Concepciones Alternativas de Alumnos de Educación Media Sobre el Fenómeno de Formación de las Fases de La Luna.) Concepções Alternativas de Alunos do Ensino Médio Sobre o Fenômeno de Formação das Fases da Lua

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo; Langhi, Rodolfo; Fernandes Scalvi, Rosa Maria

    2008-07-01

    Forty students, at ages between 14 and 18 years old, from three schools in Bauru city, were questioned about their alternative conceptions concerning the phenomenon of formation of the Moon Phases. It was observed that some of the pupils confound the phenomenon of the formation of the Moon Phases with the phenomenon of the formation of the lunar eclipses, others are unaware of the reason of the phenomenon, they present incoherent alternative conceptions of the reality or incomplete conceptions. The results found here are aimed at the teachers of Elementary Education and can be used as a subsidy for future development of new pedagogical methods. Cuarenta estudiantes, con edad entre 14 y 18 años, pertenecientes a tres escuelas de la ciudad de Bauru, fueron cuestionados sobre sus concepciones alternativas acerca del fenómeno de la formación de las fases de la Luna. Fue observado que algunos alumnos confunden el fenómeno de formación de las fases de la Luna con el fenómeno de formación de los eclipses lunares, otros desconocen el motivo delfenómeno, presentan concepciones alternativas incoherentes con la realidad o bien presentan concepciones incompletas. Los resultados aquí encontrados son destinados a los profesores de la Enseñanza Básica y podrán ser usados como ayuda para el futuro desarrollo de nuevos métodos pedagógicos. Quarenta estudantes, com idades entre 14 e 18 anos, pertencentes a três escolas da cidade de Bauru, foram questionados sobre suas concepções alternativas acerca do fenômeno de formação das fases da Lua. Foi observado que alguns dos alunos confundem o fenômeno da formação das fases da Lua com o fenômeno da formação dos eclipses lunares, outros desconhecem o motivo do fenômeno, apresentam concepções alternativas incoerentes com a realidade ou então concepções incompletas. Os resultados aqui encontrados são destinados aos professores do Ensino Básico e poderão ser usados como subsídio parafuturo desenvolvimento de

  11. [Familial microepidemic of food-borne botulism in the Region of Madrid].

    PubMed

    Jalda, D; Junco, A; Alvarez-Moreno, M; Rodero, I; Carneado-Ruiz, J

    2016-07-01

    Introduccion. El botulismo es un sindrome causado por la toxina del bacilo Clostridium botulinum. La toxina actua bloqueando las terminaciones colinergicas presinapticas de la placa motora y del sistema nervioso parasimpatico, y ocasiona una paralisis flacida y un fallo parasimpatico. El modo mas habitual de adquisicion de la enfermedad es por ingesta de toxina preformada presente en las conservas caseras mal esterilizadas, aunque otros mecanismos son posibles. Su incidencia actual en Espana es muy baja. Casos clinicos. Se describen tres miembros convivientes de una familia que presentaron un cuadro de botulismo alimentario. Las manifestaciones clinicas iniciales mostraron predileccion por la paresia ocular y por sintomatologia disautonomica de escasa especificidad, y la agregacion familiar fue el indicio fundamental que sugirio el diagnostico. Posteriormente, los pacientes empeoraron y dos de ellos presentaron afectacion de la funcion respiratoria y precisaron ingreso prolongado en la unidad de cuidados intensivos. Los tres pacientes convalecieron y se recuperaron sin secuelas. Se consiguio detectar la toxina botulinica por bioensayo en los restos de alimentos, lo que confiere al caso la categoria diagnostica de confirmado. Conclusiones. La microepidemia familiar presentada constituye un caso de afectacion inicial predominantemente ocular y disautonomica. Asimismo, ilustra varios aspectos tipicos de la enfermedad: la sospecha diagnostica ante pacientes convivientes que acuden simultaneamente por clinica similar, las complicaciones caracteristicas del proceso y su tratamiento, el diagnostico de laboratorio y su historia natural hacia la resolucion.

  12. Memories of Astronomy Education in Brazil: Clippings from the Discourses of Interviewed Researchers on the Subject. (Spanish Title: Memorias de la Educación en Astronomía en Brasil: Recortes de los Discursos de Investigadores Entrevistados Acerca del Tema ) Memórias da Educação em Astronomia no Brasil: Recortes a Partir das Falas de Pesquisadores Entrevistados sobre o Tema

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo; Nardi, Roberto

    2014-12-01

    This paper presents a historical retrospective concerning data from a research in Astronomy Education in Brazil, after 1973. It was organized on the basis of the speech analysis of national researchers considered references in this field by their peers. Furthermore, it was elaborated on the basis of other studies from the areas of Science Education, Physics and Astronomy. This historical overview was developed in order to facilitate understanding of the contexts in which the interviewed researchers have developed professionally. Moreover, we attempted to recover the memory of the growing field of research in Astronomy Education in the country. We believe that the history presented can help those trying to understand the past in an attempt to resolve current and future demands. Se presenta en este artículo una retrospectiva histórica referente a datos provenientes de la investigación en enseñanza de la astronomía en el Brasil, después de 1973, organizada sobre la base del análisis de los discursos de los investigadores nacionales considerados referencias en este campo, y también en la lectura de las publicaciones en las áreas de Enseñanza de las Ciencias, Física y Astronomía. Este repaso histórico se desarrolló con el fin de facilitar la comprensión de los contextos en los que los investigadores entrevistados se han desarrollado profesionalmente. Por otra parte, se intentó recuperar la memoria del creciente campo de la investigación en Educación en Astronomía en el país. Creemos que el relato presentado puede contribuir a quien trata de comprender el pasado, en un intento de resolver las demandas actuales y futuras. Relata-se neste artigo uma retrospectiva histórica referente a dados provenientes de pesquisa em Educação em Astronomia no país, pós 1973, organizada com base na análise das falas de pesquisadores considerados referências nacionais nesse campo, como também na leitura de publicações das áreas de ensino de Ciências, F

  13. [Children who leave the Emergency Department: missing opportunities?].

    PubMed

    Machado, Virgínia; Peças, Sofia; Periquito, Isabel; Mota, Andreia; Veiga, Estela; Balseiro, Maria de Jesus

    2014-01-01

    Introdução: As crianças que abandonam a Unidade de Urgência Pediátrica antes do seu processo de atendimento estar terminado podem apresentar um agravamento clínico posterior, relacionado com a falta de avaliação médica atempada.Objectivos: Este estudo teve como objectivo avaliar os casos de abandono na nossa Unidade de Urgência Pediátrica, caracterizar este grupo de crianças e a sua evolução clínica.Material e Métodos: Análise retrospectiva e descritiva dos processos de urgência das crianças que abandonaram a Unidade de Urgência Pediátrica do Hospital de São Bernardo antes de terminar o processo de atendimento, entre 1 de Janeiro e 31 de Dezembro de 2012.Resultados: Um total de 538 crianças abandonou a Unidade de Urgência Pediátrica (1,35% de todas as admissões). A maioria (89,5%) não apresentava critério de observação urgente e abandonou antes da observação médica inicial (82,7%). A percentagem de abandonos foi maior nos meses de Dezembro, Janeiro e Fevereiro (64%), à terça-feira (19,3%) e durante o turno da tarde (60,8%). Estes períodos coincidiram com os picos de maior afluência à Unidade de Urgência Pediátrica. O tempo de espera para observação médica foi na maioria (94,4%) adequado à gravidade clínica. Seis doentes regressaram nas 72 horas seguintes, dos quais dois necessitaram de internamento.Discussão: Verificou-se uma percentagem de abandonos dentro do expectável. A menor gravidade aferida na triagem e os tempos de espera prolongados foram factores predisponentes ao abandono.Conclusão: A sobrelotação das Urgências Pediátricas com doentes sem critérios de urgência, que aumentam os tempos de espera, pode conduzir ao abandono com posterior readmissão em situação clínica de agravamento, o que na nossa série aconteceu em apenas dois casos.

  14. [Sensitivity and specificity of prick skin test with two concentrations of standardized extract of Culex quinquefasciatus in allergic children].

    PubMed

    Castro-Almarales, Raúl Lázaro; Álvarez-Castelló, Mirta; Ronquillo-Díaz, Mercedes; Rodríguez-Canosa, José S; González-León, Mayda; Navarro-Viltre, Bárbara I; Betancourt-Mesia, Daniel; Enríquez-Domínguez, Irene; Reyes-Zamora, Mary Carmen; Oliva-Díaz, Yunia; Mateo-Morejón, Maytee; Labrada-Rosado, Alexis

    2016-01-01

    Antecedentes: las opciones diagnósticas de las reacciones inmunológicas a la picadura del mosquito son limitadas. En Cuba, las reacciones mediadas por IgE más frecuentes son por picadura de Culex quinquefasciatus. Objetivo: determinar la sensibilidad y especificidad de la prueba cutánea por punción con dos dosis del extracto estandarizado en unidades de nitrógeno proteico (UNP) de Culex quinquefasciatus (BIOCEN, Cuba). Material y método: estudio analítico efectuado en 100 niños entre 2 y 15 años de edad: 50 pacientes atópicos con antecedentes de alergia a la picadura de mosquito e IgE sérica específica positiva a Culex quinquefasciatus y 50 pacientes atópicos sin antecedentes de alergia a la picadura de mosquito e IgE sérica específica negativa a Culex quinquefasciatus. La prueba cutánea por punción se realizó por duplicado en los antebrazos de los pacientes. Las dosis investigadas fueron 100 y 10 UNP/mL. Resultados: en la prueba cutánea por punción con el extracto de mayor concentración se obtuvo un tamaño del área del habón de 22.09 mm2 y con la menor concentración de 8.19 mm2; una diferencia estadísticamente significativa (p=0.001, prueba t de Student). La prueba cutánea positiva se correlacionó en el 100% de los pacientes con la existencia de IgE específica. La prueba con ambas dosis mostró 94% de especificidad y 88% de sensibilidad. Conclusión: la alta coincidencia en el resultado de la prueba cutánea nos muestra que puede sustituirse la concentración del extracto a 100 UNP/mL por la de menor concentración, sin perder confiabilidad en el diagnóstico de sensibilización al mosquito Culex quinquefasciatus, utilizando ese método in vivo.

  15. Como Lo Hago Yo: Anomalías del Tubo Neural en Guatemala — Mielomeningocele Unidad de Espina Bífida e Hidrocefalia

    PubMed Central

    Manucci, Graciela; von Quednow, Enzo

    2014-01-01

    En Guatemala nacen por añ 786 niños con defectos de tubo neural. Operamos 65 a 70 niños con mielomenigocele por año. Tenemos equipo multidisciplinario. Recomendamos parto por cesárea. Infección antes de la cirugía es un problema mayor. Derivación tardía es un problema. Disecamos la plaqueta con la técnica clásica. Suturamos la plaqueta para restituir la forma de la médula. Corpectomía en casos de cifósis. Hidrocefalía: Operamos el 80% de los niños. Chiari II: Operamos basados en los síntomas, primero nos aseguramos que la válvula funciona bien. Médula anclada: Operamos basados en los síntomas. PMID:24791216

  16. Raza de Tesoros. Programa de Lectura y Ensenanza del Lenguaje, Unidad B. Guia para el Maestro (Race of Treasures. Reading and Language Learning Program, Unit B. Teacher's Guide).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This is the teacher's guide accompanying a reader and a workbook that are part of an ungraded language arts and reading program that can be used in classes from upper elementary through high school. The program is designed around reading selections which present aspects of history, culture, and present-day experiences of special relevance to the…

  17. Escaparate. Programa de lectura y ensenanza del lenguaje, Unidad C. Guia Para El Maestro (Show Window. Reading and Language Learning Program, Unit C. Teacher's Guide).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    Instructions for use of "Escaparate," the third of eight Spanish reading and language instruction units developed by Edgewood School District's Bilingual Program, San Antonio, Texas, are given in this teacher guide. Originally intended for grades four through six, the program may be used from fourth grade to secondary school in Spanish reading and…

  18. Escaparate. Programa de lectura y ensenanza del lenguaje, Unidad C. Cuaderno de Trabajo (Show Window. Reading and Language Learning Program, Unit C. Workbook).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    Exercises, tests, puzzles, enrichment activities, maps, and games are included in this student workbook for "Escaparate," the third in a series of eight Spanish reading and language instruction units developed by the Bilingual Program of Edgewood School District, San Antonio, Texas. The publication can be used as ditto sheets for duplicating or in…

  19. Raza de Tesoros. Programa de Lectura y Ensenanza del Lenguaje, Unidad B. Cuaderno de Trabajo (Race of Treasures. Reading and Language Learning Program, Unit B. Workbook).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This workbook in Spanish accompanies the reader that is part of an ungraded language arts and reading program that can be used in classes from upper elementary through high school. The program is designed around reading selections which present aspects of history, culture, and present-day experiences of special relevance to the Mexican-American…

  20. Raza de Tesoros. Programa de Lectura y Ensenanza del Lenguaje, Unidad B (Race of Treasures. Reading and Language Learning Program, Unit B).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This Spanish reader is part of an ungraded language arts and reading program that can be used in classes from upper elementary through high school. The program is designed around reading selections which present aspects of history, culture, and present-day experiences of special relevance to the Mexican-American student. The goals of the program…

  1. Planeamiento de la unidad didactica en le ensenanza del ingles como idioma extranjero (Planning the Teaching Unit in the Instruction of English as a Foreign Language).

    ERIC Educational Resources Information Center

    Medina T., Rene

    1971-01-01

    This paper discusses the use of the teaching unit as a means for organization in English-as-a-foreign-language classes. It lists the essential elements in the construction of such a unit: cultural topic, linguistic elements, time period, main objectives, instructional materials, focus, specific activities, intended results, evaluation techniques,…

  2. 76 FR 44609 - United States-Peru Trade Promotion Agreement Notice of Determination Regarding Review of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ..., 2010, by a Peruvian union, the Sindicato Nacional de Unidad de Trabajadores de Superintendencia..., the Sindicato Nacional de Unidad de Trabajadores de Superintendencia Nacional de Administraci...

  3. A Integracao de Ensino das Ciencias da Saude (An Integrated Medical Education Program [in Brazil]).

    ERIC Educational Resources Information Center

    Pourchet-Campos, M. A.; Guimaraes Junior, Paulino

    At the Sixth Annual Reunion of the Brazilian Association of Medical Schools (VI Reuniao Anual da Associacao Brasileira de Escolas Medicas) leaders in the Brazilian medical profession proposed an integrated educational program for training students in the fields of medicine and public health. Under Brazil's present system of education, all…

  4. Renewing information infrastructure at Hospital das Clínicas.

    PubMed Central

    Moura, L.; do Amaral, M. B.; Lira, A.; Tachinardi, U.; Teixeira, A. C.; Yamamoto, J.

    1998-01-01

    In this paper we describe the process of renewing the Informatics infrastructure of Sao Paulo University Medical School Hospital, a very complex environment. Our proposal consists of a change in the paradigm of Informatics and the use of Information Technology in the hospital. That change aims at making information available to the hospital, its managers, health care workers and patients. The paradigm change is reflected in every aspect of the new infrastructure: human resources, methods, and organizational structure, as we intend to demonstrate in this paper. This process is expected to be concluded by the end of this year, yielding benefits regarding costs, efficiency, and better patient care. PMID:9929210

  5. Das Schwimmen der Talitridae (Crustacea, Amphipoda): Funktionsmorphologie, Phänomenologie und Energetik

    NASA Astrophysics Data System (ADS)

    Vogel, Friedhelm

    1985-09-01

    The Talitridae, well-known for their jumping behaviour, swim with help of the tail-flip. This movement of the abdomen is also known from other amphipods like the Gammaridae which are normally not able to move by jerks outside the water. The suspected homology between the tail-flip when swimming and the jerky movement of the abdomen when jumping gave rise to this investigation, mainly based on high frequency film recordings, on the swimming of Hyale nilssonii, Orchestia cavimana, and Talitrus saltator (family Talitridae) as well as three related species of the families Gammaridae and Corophiidae. Comparative morphometrical and SEM-studies on the habitus of the species and the build of the involved limbs reveal the rather uniform construction of the Gammaridea; functional adaptation to the environment and to the way of living become apparent in minor alterations. The joints of the pleopods and uropods show a clear structural adaptation to the mechanical strain during swimming. The pleopods are moved metachronally in all examined species; angular velocity and rate of beating indicate the efficiency of the swimming movement. In the Talitridae, the metachronal beat of the pleopods is nearly always coupled with the tail-flip while in the Gammaridae and Corophiidae the tail-flip, in addition to the beat of the pleopods, is mostly used for a start from the subsoil or for a change in swimming direction. H. nilssonii, Gammarus locusta, and Corophium volutator, all inhabitants of the tidal zone in the North Sea shallows, turned out to be the “best” swimmers while the (semi-) terrestrially living species, O. cavimana and T. saltator, proved to be rather “poor” swimmers. This clearly indicates the ecological significance of swimming for the different species. Furthermore, the tailflip is found to be of rather subordinate importance. It contributes to a higher velocity if used moderately but is rather obstructive if a large angle is covered while extending and flexing the abdomen. The efficiency of swimming is inversely proportional to the efficiency of jumping in the three talitridean species. Thus, better adaptation to terrestrial life is accompanied by loss of swimming efficiency. Examined under the aspect of locomotional homology, it is concluded that the tail-flip used while swimming is homologous to the jerky movement of the abdomen used for jumping. The comparison of the swimming performance of the examined species with other crustaceans and some fishes illustrates the over-all good results of the Gammaridea.

  6. Joint Confirmatory Factor Analyses of the DAS and WISC-R.

    ERIC Educational Resources Information Center

    Stone, Brian J.

    1992-01-01

    Investigated joint factor structure of Differential Abilities Scale and Wechsler Intelligence Scale for Children-Revised for 115 children. Compared theoretically supportable models (Spearman's General factor; Wechsler's Verbal, Performance, and Freedom from Distractibility factors; Elliott's verbal, nonverbal, spatial, and diagnostic perspective)…

  7. Consideracoes Extemporaneas acerca das Metodologias Qualitativas (Extemporaneous Considerations about Qualitative Methodology).

    ERIC Educational Resources Information Center

    Pucci, Bruno

    2000-01-01

    Considers the differences between quantitative and qualitative research. Cites some essays by Adorno when he was living in New York which led to the conclusion that empirical data has much to say and discusses the theoretical-methodological contributions in a recent master's thesis in education. (BT)

  8. O Universo das Sociedades Numa Perspectiva Relativa: Exercícios de Etnoastronomia

    NASA Astrophysics Data System (ADS)

    Fares, Érika Akel; Pessoa Martins, Karla; Maciel Araujo, Lidiane; Sauma Filho, Michel

    2004-12-01

    This work developed at the Planetarium of Pará employing workshops designed for visitor schools (public, private, specials groups), promotes the popularization of the Ethnoastronomy with the aim of diffusing values based on a cultural diversity tolerance and the need of harmonic interplay between people and environment. Using stories and debates, the relationship between humans and the Cosmos is traced from antiquity until today, with the help of slides as a didactic resource. Thus, many conceptions about the origin of the Universe are shown; as well as some constellations created along the History, ending with the present scientific manner of know and explain the World. We then demonstrate the links between space, time and culture with the Cosmos vision. The need to think the World within a plural context to create respect for other different persons is emphasized. Este trabalho, desenvolvido no Planetário do Pará através de oficinas com escolas visitantes (públicas, privadas e grupos especiais), promove a popularização da Etnoastronomia, com o objetivo de difundir valores pautados na tolerância à diversidade cultural e na necessidade da convivência harmônica entre o ser humano e o meio ambiente. Através da contação de histórias e promoção de debate, é tratada a relação dos humanos com o céu desde a antiguidade até os dias atuais, tendo como apoio didático o uso de slides. Assim, são mostradas diversas concepções de origem do Universo; algumas constelações criadas no decorrer da História; e a atual forma científica de conhecer e explicar o mundo. Demonstrando-se, então, a interligação entre espaço, tempo e cultura com a visão do Cosmo. Enfatiza-se a necessidade de se pensar o mundo numa perspectiva relativa ou plural, de forma a propiciar o respeito ao ser diferente.

  9. Das Ende der Nacht [The End of the Night (2nd enlarged ed.)

    NASA Astrophysics Data System (ADS)

    Posch, Thomas; Hölker, Franz; Uhlmann, Thomas; Freyhoff, Anja

    2013-09-01

    We provide provide an overview of the history of lighting and of the problems arising from artificial lighting. The book covers the following topics: A brief history of light (ch. 1); night and light in cultural history (ch. 2); light pollution in central Europe (ch. 3); Moths and artificial lights (ch. 4); Artificial lighting and birds (ch. 5); Ocean turtles as victims of beach lighting (ch. 6); Moon light as a zeitgeber for the marine fauna (ch. 7); the influence of artificial light at night on freshwater ecology (ch. 8); artificial light and human health (ch. 9); the loss of the night in a 24 hours society (ch. 10).

  10. A Data Acquisition System (DAS) for marine and ecological research from aerospace technology

    NASA Technical Reports Server (NTRS)

    Johnson, R. A.

    1972-01-01

    The efforts of researchers at Mississippi State University to utilize space-age technology in the development of a self-contained, portable data acquisition system for use in marine and ecological research are presented. The compact, lightweight data acquisition system is capable of recording 14 variables in its present configuration and is suitable for use in either a boat, pickup truck, or light aircraft. This system will provide the acquisition of reliable data on the structure of the environment and the effect of man-made and natural activities on the observed phenomenon. Utilizing both self-contained analog recording and a telemetry transmitter for real-time digital readout and recording, the prototype system has undergone extensive testing.

  11. Das Sprachlabor und der Audiovisuelle Unterricht (The Language Laboratory and Audiovisual Instruction).

    ERIC Educational Resources Information Center

    Freudenstein, Reinhold, Ed.

    Four articles, written in German, discuss such aspects of the language laboratory as: teaching pronunciation in the laboratory (Heinrich Schrand), the dummy-element in transformational grammar (Helmut Heuer), testing in the language laboratory (Kenneth S. Leigh), and language laboratory work in Finland (Roland Freihoff). Nine book reviews on…

  12. Bring Back "Das Kapital" Punishment! Credit Crunch and the Fall of the "Knowledge Economy"

    ERIC Educational Resources Information Center

    Stronach, Ian; Clarke, John

    2010-01-01

    This article contrasts the collapse of the twin political certainties of the 20th century--"scientific socialism" (1989) and "scientific capitalism" (2008). Such a collapse restores Uncertainty to her throne, and brings back the need to radically rethink political possibilities for the future. (Contains 1 note.)

  13. Kindern das Wort Geben ein interkulturell-kreativer Arbeitsansatz, aufgezeigt an der Arbeit mit tibetischen Migrantenkindern

    NASA Astrophysics Data System (ADS)

    Rabkin, Gabriele

    2001-03-01

    Promotion of creativity in the cause of peace and international understanding is a fundamental part of the UNESCO programme to build a culture of peace. A central aspect of this undertaking consists in encouraging children to express themselves freely on this subject in writing and art. An approach has been developed to stimulate children's creativity and to create a link between creative expression and education for intercultural understanding. This article is divided into two parts. The first explains the pedagogical and psychological concepts behind this approach. The second describes a project in which these concepts were applied. It focuses on a minority dispersed over many parts of the world, namely children of Tibetan families. The description is accompanied by commentaries of the Fourteenth Dalai Lama, arising from a personal audience granted to the author in 1999.

  14. Ein Mensch ist ein Tier, das Schuhe tragt: Communication not Manipulation

    ERIC Educational Resources Information Center

    Sanders, Ruth H.

    1978-01-01

    A technique is described for eliciting true communication in the elementary German classroom which is also applicable to more advanced study. Students define simple words in German and are encouraged to help one another build a cumulative definition. The instructor reinforces the concept of language as a social activity. (SW)

  15. Vehicle DAS Considerations for the Iron Gorget Threats: Analysis, Modelling and Comments to Operations Researchers

    DTIC Science & Technology

    2007-02-01

    10 Figure 8. RPG -7 radiance image ... imaging infrared, to detect and home in on targets. – BAT (Brilliant Anti-Tank) is an acoustic and infrared guided submunition that searches, tracks and...CO2 2.056×10−1 H2 2.076×10−1 14 DRDC Valcartier TM 2004–356 Figure 8. A radiance image from the RPG -7, the image is 0.4 m wide and 0.2 m high. DRDC

  16. Kepler, Galilei, the telescope and the consequences. (German Title: Kepler, Galilei, das Fernrohr und die Folgen)

    NASA Astrophysics Data System (ADS)

    Gaulke, Karsten; Hamel, Jürgen

    The papers of this volume are dedicated to Johannes Kepler, the astronomy of his time, and the consequences of his researches. They deal with the reception on the Copernican system of the world at the court of landgrave William IV in Kassel and the use of astronomy at a princely court in the 16th century, exemplified by the Kassel residence. Two contributions discuss a text fragment in Kepler's Astronomia Nova and the dimensions of the geo- and heliocentric systems of the world in Kepler's Mysterium Cosmographicum. Other contributions deal with mathematical aspects un Kepler's exchange of letters, the biography of Kepler's discussion partner Ph. Feselius, as well as the early reception of the Tabulae Rudolphinae in the calendar literature, telescopes in Kepler's time, Chr. Scheiner's optical theory of the eye, and finally in the continuation of the heliocentric world system by Otto von Guericke's natural philosophy and science. In conclusion, the documents of the planned call of Kepler to Rostock university, as well as the first publication of a recently found, hitherto unknown letter by Kepler.

  17. Diskrepanzen und Kongruenzen: Das Dilemma des afrikanischen Kindes zwischen Familie und Schule

    NASA Astrophysics Data System (ADS)

    Bauer, Annemarie

    1986-03-01

    This article expounds the theory that the failure of school is due to the incompatibility of the educational goals of school and traditional upbringing in Africa. The thesis is put forward by adherents of the psychoanalytical model of child development and seeks to emphasize the discrepancies between the childhood where children are not frustrated and where their needs are cared for and the school education which represses the drives and its socialization of children. Finding a number of anthropological studies are discussed and reinterpretations of the ethno-psychoanalytical materials attempted. Neither the evaluation of childhood in Africa nor the theory that with school come wholly new expectations of behaviour (e.g., a performance requirement) can no longer be maintained. In conclusion, other explanations for the difficulties encountered by school in Africa are offered.

  18. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Inlet Entrance Buoy “HI” 35°10′ 75°46′ 49. Ocracoke Inlet Whistle Buoy “OC” 35°01.5′ 76°00.5′ 50. A... of 7 days. (C) If, under the exemption for a minimum of 7 days and wishing to withdraw earlier...

  19. Das Gymnasium Zwischen Tradition und Modernen Bildungsanspruchen (The Gymnasium between Tradition and Modern Educational Requirements).

    ERIC Educational Resources Information Center

    Heller, Kurt A.

    2003-01-01

    Provides brief history of the German Gymnasium as a traditional European secondary school system with a preparatory function for higher education. Reviews the main goals of the gymnasium. Asks what role the gymnasium plays as a learning environment for gifted students. Discusses the politico-educational consequences and demands on the gymnasium.…

  20. The Electron Microscope as an Aid in Colloid Research (Das Elektronenmikroskop als Hilfsmittel der Kolloidforschung),

    DTIC Science & Technology

    1978-03-09

    prepared from one part lithium carbonate and two parts boric acid , is blown quickly at the correct inetant during cooling, very thin• films can be...selected as an example. Because gold dispersions in borax glass are easier to prepare than those in silicate glass, we studied a borax pyrosol. The...mean gold particle size in borax melts prepared in various ways have been calculated by EHRINGHAUS and WINTGEN (7) from the gold concentration and the

  1. Das Werden des Kosmos. Von der Erfahrung der zeitlichen Dimension astronomischer Objekte im 18. Jahrhundert.

    NASA Astrophysics Data System (ADS)

    Krafft, F.

    This paper deals with two of the initial stages through which the dimension of time, in the sense of an irreversible development, found its way into astronomical-cosmological thinking. The one resulted from the first consequential application of Newtonian principles and laws to cosmic entities outside of our solar system found in the "General Natural History or Theory of the Heavens" by Immanuel Kant. The other initial stage is found in the classification of 'nebulae' by William Herschel who introduced the historical time factor as a principle of order in addition to the outward shape, which had become common for all the different elements in natural history during the second half of the 18th century.

  2. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... scallop vessel issued an Occasional limited access permit when fishing under the Sea Scallop Area Access... Atlantic sea scallop limited access permit, the vessel owner signs out of the VMS program for a minimum..., or while the vessel was not at sea. (e) VMS notifications—(1) VMS installation notification. (i)...

  3. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... scallop vessel issued an Occasional limited access permit when fishing under the Sea Scallop Area Access... Atlantic sea scallop limited access permit, the vessel owner signs out of the VMS program for a minimum..., or while the vessel was not at sea. (e) VMS notifications—(1) VMS installation notification. (i)...

  4. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... scallop vessel issued an Occasional limited access permit when fishing under the Sea Scallop Area Access... Atlantic sea scallop limited access permit, the vessel owner signs out of the VMS program for a minimum..., or while the vessel was not at sea. (e) VMS notifications—(1) VMS installation notification. (i)...

  5. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... scallop vessel issued an Occasional limited access permit when fishing under the Sea Scallop Area Access... Atlantic sea scallop limited access permit, the vessel owner signs out of the VMS program for a minimum..., or while the vessel was not at sea. (e) VMS notifications—(1) VMS installation notification. (i)...

  6. The Shadow of a Gnomon Along a Year: Routine Observations and Teaching of Apparent Motion of the Sun and the Four Seasons. (Spanish Title: La Sombra de un Gnomon lo Largo de un Año: Observaciones de Rutina y la Enseñanza del Movimiento Aparente del Sol y Las Cuatro Estaciones.) A Sombra de um Gnômon ao Longo de um Ano: Observações Rotineiras e o Ensino do Movimento Aparente do Sol E das Quatro Estações

    NASA Astrophysics Data System (ADS)

    Trogello, Anderson Giovani; Danhoni Neves, Marcos Cesar; de Carvalho Rutz da Silva, Sani

    2013-12-01

    , al solsticio de junio, al equinoccio de septiembre y al solsticio de diciembre. Además, se dictaron clases teóricas en la sala de aula. Estos métodos buscaron construir conceptos en torno al movimiento aparente del Sol y la sucesión de las estaciones. Teniendo en cuenta los resultados de las actividades se aplicó una evaluación cuyos datos demuestran la existencia de un aprendizaje deseado por los estudiantes en cuanto a: el reconocimiento de los puntos cardinales, la descripción del movimiento solar aparente y la aparición de las estaciones y su alternancia a partir de observaciones astronómicas visuales sin instrumentos. Muitas concepções alternativas são reconhecidas entre os diversos grupos de estudantes, em especial nos da educação básica. Dentre elas, o movimento aparente do Sol, por mais quotidiano que seja, proporciona variadas interpretações. Deste modo, observar e registrar o movimento dos astros na abóboda celeste é uma tarefa necessária ao ensino de Astronomia. O trabalho que ora se apresenta propõe a apresentação dos resultados da observação do movimento aparente do Sol por intermédio da marcação da sombra de um gnômon vertical por alunos de uma turma do sexto ano do ensino fundamental de uma escola do campo do Paraná. O projeto em si ocorreu em quatro etapas, em datas próximas do equinócio de março, do solstício de junho, do equinócio de setembro e do solstício de dezembro. Além disso, foram desenvolvidas aulas teóricas em sala de aula. Tais métodos buscaram construir conceitos em torno da movimentação aparente do Sol e da alternância das estações do ano. Diante dos resultados provenientes das atividades desenvolvidas foi aplicada uma avaliação e os dados demonstraram um aprendizado desejado dos alunos quanto: ao reconhecimento dos pontos cardeais; à descrição do movimento solar aparente e a ocorrência das estações do ano e sua alternância a partir de observações astronômicas a olho nu.

  7. [Bone Fractures in a Neonatal Intensive Care Unit].

    PubMed

    Machado, Angela; Rocha, Gustavo; Silva, Ana Isabel; Alegrete, Nuno; Guimarães, Hercília

    2015-01-01

    Introdução: As fraturas ósseas são raras durante o período neonatal. Algumas das fraturas, sobretudo as de ossos longos, podem ocorrer durante o parto. Por outro lado, os recém-nascidos internados em Unidades de Cuidados Intensivos Neonatais têm um risco aumentado de fraturas ósseas por várias razões.Objetivo: Avaliar a incidência e caracterizar as fraturas ósseas nos recém-nascidos internados numa Unidade de Cuidados Intensivos Neonatais nível III.Material e Métodos: Análise retrospetiva dos recém-nascidos internados na Unidade de Cuidados Intensivos Neonatais com o diagnóstico na alta de uma ou mais fraturas ósseas, entre janeiro de 1996 a junho de 2013.Resultados: Oitenta recém-nascidos apresentaram uma ou mais fraturas ósseas. Em 76 (95%) recém-nascidos, as fraturas foram atribuídas a traumatismo do parto. A fratura mais comum foi da clavícula em 60 (79%) recém-nascidos, seguida da fratura craniana em 6 (8%) recém-nascidos. Em dois (2,5%) recém-nascidos, prematuros de extremo baixo peso, as fraturas foram interpretadas como decorrentes de osteopenia da prematuridade. Ambos apresentaram fraturas múltiplas, um dos quais de várias costelas.Conclusão: Uma mudança das práticas obstétricas, aliada à melhoria dos cuidados prestados ao recém-nascido prematuro contribuíram para a diminuição da incidência de fraturas ósseas no período neonatal. Contudo nos recém-nascidos prematuros o seu diagnóstico pode estar subestimado, dado o elevado risco de desenvolvimento de fratura que estes recém-nascidos apresentam.

  8. Toxic epidermal necrolysis: the experience of Coimbra's burn unit.

    PubMed

    Pinheiro, Susana; Carvalho, Ricardo; Ramos, Sara; Diogo, Carla; Caetano, Marisa; Cabral, Luís; Cruzeiro, Celso

    2013-01-01

    Introdução: A necrólise epidérmica tóxica é uma doença sistémica grave, potencialmente fatal, caracterizada por febre, descolamento dermoepidérmico extenso e erosão das mucosas. Em 95% dos casos, consiste numa reacção idiossincrática à administração de fármacos. A gravidade da doença é estratificada através da aplicação de uma escala de previsão da mortalidade, denominada SCORTEN. O tratamento obriga à suspensão imediata do fármaco suspeito e à referenciação do doente a uma Unidade de Queimados capaz de assegurar um tratamento específico.Material e Métodos: Estudo retrospectivo de 21 doentes internados com SJS/ Necrólise Epidérmica Tóxica na Unidade de Queimados dos Hospitais da Universidade de Coimbra, entre Janeiro de 1999 e Dezembro de 2010 com avaliação dos resultados e das opções terapêuticas. Comparação das taxas de mortalidade desses doentes com as previstas pelo SCORTEN, no sentido de avaliar a capacidade preditiva desta escala. Os dados foram analisados no programa SPSS 17.0®.Resultados: Foram internados 13 doentes do sexo feminino (61,9%) e 8 do sexo masculino (38,1%), com média de idades de 55,6 ± 23,7 anos e com 51% ± 22,4% de superfície corporal atingida. A taxa de mortalidade dos doentes internados foi de 47,6% e a prevista pelo SCORTEN foi de 42,2%. %. O tratamento instituído centrou-se na remoção imediata do fármaco suspeito e na referenciação precoce do doente para a unidade.Conclusão: A fisiopatologia da necrólise epidérmica tóxica não está completamente esclarecida, pelo que não existe actualmente uma terapêutica específica, comprovadamente eficaz. A utilização do SCORTEN permite uma previsão adequada da taxa de mortalidade nestes doentes.

  9. Impact of Compliance with a Sepsis Resuscitation Bundle in a Portuguese Emergency Department.

    PubMed

    Carvas, Joao Miguel; Canelas, Cátia; Montanha, Gustavo; Silva, Carlos; Esteves, Francisco

    2016-02-01

    Introdução: A sépsis severa e o choque sético são entidades clínicas frequentes com elevada morbi-mortalidade que superam os da doença cardíaca coronária ou do acidente vascular cerebral. A realidade da sépsis tratada no hospital fora das unidades de cuidados intensivos é amplamente desconhecida. Pretende-se neste trabalho estimar o cumprimento da bundle das 6-horas da Surviving Sepsis Campaign num serviço de urgência português e os resultados clínicos dos doentes. Material e Métodos: Estudo retrospetivo, observacional de coorte com 178 pacientes com sépsis severa/choque sético internados na unidade de cuidados intensivos e intermédios entre 1 de Janeiro de 2012 e 31 de Dezembro de 2012. Resultados: Durante o período estudado foi diagnosticado choque sético em 100 pacientes (56,2%) e sépsis severa em 78 pacientes (43,8%). O cumprimento com a bundle foi: (1) 62,9% para a medição de lactatos; (2) 62,9% para a colheita hemoculturas antes da antibioterapia; (3) 41,6% para a administração de antibióticos nas primeiras 3 horas; (4) 76,4% para a administração de fluidos; (5) 25% para a administração de vasopressores; (6) 37% for medição da pressão venosa central; (7) 39% para a medição da saturação venosa central de oxigénio. O cumprimento de todas as medidas foi observado em 22% dos pacientes. A medida 'colheita hemoculturas antes da antibioterapia' esteve significativamente associada a um menor risco de mortalidade na unidade de cuidados intensivos e aos 28 dias. Também se verificou uma tendência para uma correlação inversa entre cumprimento crescente da bundle e a mortalidade na unidade de cuidados intensivos e aos 28 dias. Discussão: A baixa adesão à bundle das 6-horas da Surviving Sepsis Campaign é um resultado que replica o de estudos internacionais semelhantes. A explicação para este fenómeno é complexa mas pode incluir a falta de monitorização da qualidade dos cuidados no serviço de urgência. Conclusões: O

  10. [Quality care in an intensive therapy unit at private hospital].

    PubMed

    Tejeda-Miranda, Mauricio; Anthon-Mendez, Francisco Javier; Esponda-Prado, Juan Gerardo; Rendón-Macías, Mario Enrique

    2015-01-01

    Introducción: el objetivo es evaluar la calidad de la atención en una unidad de terapia intensiva con índices internacionales de calidad. Métodos: estudio descriptivo, en una unidad de cuidados intensivos de atención privada en México. Se analizan los indicadores de 2012 con un total de 446 pacientes hospitalizados. Los indicadores de calidad fueron acordes a recomendaciones internacionales. La gravedad fue determinada por la escala SAPS III. Resultados: el indicador de neumonías asociadas a ventilación se encontró por debajo del estándar recomendado (11.7 frente a 12 por mil); la bacteremia relacionada a catéter venoso central en rangos aceptados (5.7 frente a 4 por mil). Las acciones de profilaxis de úlceras, prevención de tromboembolia pulmonar y prevención de caídas en altas proporciones de cumplimiento (> 90, > 95 % y 0 caídas). Las tasas de extubación no programada y reintubaciones estuvieron por debajo de los indicadores (< 1 por mil días intubación y < 12 %). La mortalidad fue menor a la estimada por la gravedad. Conclusión: En esta terapia la implementación de acciones recomendadas a nivel internacional ha permitido mantener una adecuada calidad de atención. El esfuerzo a impactado no solo a los pacientes con condiciones agudas de ingreso, sino también a pacientes con alto riesgo de mortalidad.

  11. [Neonatal Morbidity in Term Newborns Born by Elective Cesarean Section].

    PubMed

    Resende, Maria Cristina; Santos, Lea; Santos Silva, Isabel

    2015-01-01

    Introdução: A cesariana eletiva quando realizada antes das 39 semanas de idade gestacional associa-se a maior morbilidade neonatal e a maior risco de internamento em unidades de cuidados intensivos neonatais.Objetivo: Avaliar a morbilidade neonatal em recém-nascidos de termo, nascidos por cesariana eletiva. Material e Métodos: Estudo retrospetivo de todas as cesarianas eletivas realizadas com idade gestacional superior ou igual a 37 semanas numa maternidade de apoio perinatal diferenciado, nos últimos 11 anos (2003 - 2013). Foram excluídas as gestações de risco nomeadamente com rotura prematura de membranas, pré-eclampsia, diabetes mellitus mal controlada, isoimunização Rh, malformações congénitas e gestações múltiplas. Foi feita a comparação entre os grupos de recém-nascidos com idade gestacional inferior a 39 semanas e superior ou igual a 39 semanas. Resultados: Da amostra de 3213 recém-nascidos, 45% (1427) nasceram de cesariana eletiva antes das 39 semanas. Estes recémnascidos tiveram mais internamentos na Unidade de Cuidados Intensivos, odds ratio 2,4 [1,4 - 4,1] p = 0,001, mais morbilidade respiratória, odds ratio de 2,4 [1,6 - 3,8] p < 0,001, mais hiperbilirrubinémia com necessidade de fototerapia odds ratio 2,3 [1,5 - 3,7] p < 0,001, mais hipoglicémia e/ou dificuldade alimentar odds ratio 1,6 [1,2 - 2,4] p = 0,006 e mais internamentos com duração superior a cinco dias odds ratio 2,0 [1,4 - 3] p < 0,001.Discussão: Os recém-nascidos com idade gestacional inferior a 39 semanas tiveram maior morbilidade respiratória e metabólica e consequentemente tiveram maior número de dias de internamento. Conclusão: Ao contrário do que está preconizado ainda existe na instituição um elevado número de cesarianas eletivas antes das 39 semanas. Devem ser programadas acções no sentido de sensibilizar os profissionais para este problema.

  12. Predictive ability of the anthropometric and body composition indicators for detecting changes in inflammatory biomarkers.

    PubMed

    de Carvalho Vidigal, Fernanda; Paez de Lima Rosado, Lina Enriqueta Frandsen; Paixão Rosado, Gilberto; de Cassia Lanes Ribeiro, Rita; do Carmo Castro Franceschini, Sylvia; Priore, Silvia Eloiza; Gomes de Souza, Eliana Carla

    2013-01-01

    Introducción: La obesidad ha sido considerada como una inflamación crónica subclínica. La proteína C-reactiva ultrasensible (PCR-us) y el fibrinógeno se han asociado cada vez más con el riesgo cardiovascular. Objetivos: Evaluar la capacidad, de los indicadores antropométricos y de composición corporal, en discriminar mayores niveles séricos de PCR-us y fibrinógeno. Métodos: Se evaluaron 130 hombres (20-59 años). Se midió peso, estatura, circunferencia de la cintura, de la cadera y del muslo, diámetro abdominal sagital (DAS), diámetro coronal (DC) y composición corporal. Se calculó el índice de conicidad, la relación cintura/estatura, el índice de masa corporal, la relación cintura/cadera, la relación cintura/muslo y el índice sagital. Se consideró como punto de corte para los valores de PCR-us ≥?0,12 mg/dl y para el fibrinógeno se utilizó el percentil 50 de la muestra evaluada. Resultados: El índice sagital (r = 0,280), la relación cintura/ muslo (r = 0,233) y la relación cintura/estatura (r = 0,233) mostraron una mejor correlación con la PCR-us (p < 0,01). El índice de conicidad (r = 0,305) y la relación cintura/estatura (r = 0,279) mostraron una mejor correlación con el fibrinógeno (p < 0,01). En el análisis ROC, el DAS (0,698 ± 0,049) y el índice de conicidad (0,658 ± 0,048) mostraron una mayor capacidad predictiva de riesgo cardiovascular determinado a través de mayores niveles de PCR-us y fibrinógeno, respectivamente (p < 0,01). Los puntos de corte de 30 cm, 89,9 cm y 20,5 fueron los que alcanzaron mayor sumatorio entre los valores de sensibilidad y especificidad para el DC, circunferencia de la cintura y DAS, respectivamente. Conclusiones: En hombres adultos sanos, el DAS y el índice de conicidad mostraron una mayor capacidad predictiva para detectar niveles más altos de PCR-us y fibrinógeno respectivamente.

  13. Off-Label and Unlicensed Drug Use in Neonatology: Reality in a Portuguese University Hospital.

    PubMed

    Silva, Joana; Flor-de-Lima, Filipa; Soares, Henrique; Guimarães, Hercília

    2015-01-01

    Introdução: Este estudo pretende caracterizar os medicamentos usados numa Unidade de Cuidados Intensivos Neonatais portuguesa, avaliar a frequência do uso de fármacos off-label ou não licenciados de acordo com a informação disponível no Resumo das Caraterísticas do Medicamento e comparar resultados entre recém-nascidos prematuros e de termo.Material e Métodos: Um estudo retrospetivo transversal foi conduzido na nossa Unidade de Cuidados Intensivos Neonatais no primeiro semestre de 2013. Os dados das prescrições realizadas foram comparados com a informação pediátrica contida nos Resumos das Caraterísticas do Medicamento.Resultados: Analisámos 1011 prescrições respeitantes a 84 substâncias ativas, feitas em 218 admissões. Em 42,9% dos casos, os fármacos foram usados de acordo com a informação do Resumo das Caraterísticas do Medicamento; 27,9% dos fármacos eram aprovados para o período neonatal mas usados de forma off-label; medicamentos off-label para a idade neonatal foram usados em 10,1%, enquanto aqueles com estado de aprovação indeterminado ou contraindicados foram usados em 6,0% e 8,7% dos casos, respetivamente. As prescrições não licenciadas representaram 4,4% do total. Os recém-nascidos pré-termo receberam uma taxa superiorde fármacos usados de acordo com o Resumo das Caraterísticas do Medicamento (p < 0,0001), enquanto os de termo receberam mais fármacos off-label para dose/frequência (p < 0,0001) e contraindicados para recém-nascidos (p < 0,012).Discussão: Os prematuros receberam um número mediano de fármacos superior, o que se relaciona com o seu internamento mais prolongado. A principal razão para prescrições off-label foi a utilização de doses/frequências de administração diferentes das referidas no Resumo das Caraterísticas do Medicamento, reforçando a necessidade de atualização destes documentos. A manipulação dosmedicamentos é uma das causas para o seu uso não licenciado, enfatizando a falta de

  14. [Adalimumab versus etanercept in the treatment of active rheumatoid arthritis: cost-effectiveness analysis].

    PubMed

    González Álvarez, A; Gómez Barrera, M; Borrás Blasco, J; Giner Serrer, E J

    2013-01-01

    Objetivo: Valorar el grado de efectividad y eficiencia de las dos alternativas principalmente utilizadas en nuestro ámbito, etanercept (ETN) y adalimumab (ADA), para el tratamiento de pacientes diagnosticados de artritis reumatoide (AR) en condiciones reales de la práctica clínica diaria. Material y método: Se realizó un estudio observacional retrospectivo, cuyo horizonte temporal fue de 12 meses referidos al año 2012, en el que se analizaron las características de los pacientes, así como la efectividad y eficiencia de ETN y ADA en la población de estudio. Se estudiaron todos los pacientes de ambos sexos mayores de 18 años, diagnosticados de AR, atendidos en las consultas externas del Servicio de Reumatología del Sector Sanitario de Teruel. Se determinó el descenso medio del valor de DAS28 (DAS28r) de cada fármaco y se definió como unidad de efectividad en el estudio farmacoeconómico un valor DAS28 al inicio (DAS28a) inferior a 3,2 puntos y DAS28r mayor a 1,2 puntos. Como parámetro del estudio para determinar el coste-efectividad de ambas alternativas se utilizó el beneficio neto sanitario (BNS). Resultados: El valor medio de DAS28a fue 2,25 y 2,72 puntos para ETN y ADA respectivamente, con un valor DAS28r de 1,01 puntos superior para ETN, aunque sin ser estadísticamente significativo (p > 0,05). El cálculo del parámetro BNS obtuvo un valor igual a -0,121; IC95% (-0,951 a 0,709), sin embargo la inclusión del valor 0 en el intervalo de confianza hizo que no se observaran diferencias de coste-efectividad. Conclusiones: Ambas alternativas son efectivas en el tratamiento de la AR, aunque parece existir una tendencia a favor de ETN en el grado coste-efectividad sin ser significativa.

  15. Wet and Wild: A Multidisciplinary Marine Education Teacher Guide, Grades K-6. Unit I. The Physical Ocean: Wet, Wild, and Deep = Humedo y Salvaje. Primera Unidad. El Oceano Fisico: Humedo, Salvaje y Profundo.

    ERIC Educational Resources Information Center

    Murphy, Richard C.

    Topics and activities related to the physical ocean are the focus of this multidisciplinary, marine education teaching guide for students in kindergarten through grade 6. The guide is divided into seven sections (labeled A through G). The first six sections consist of various kinds of activities, with the appropriate grade levels (K-6, K-3, or…

  16. Metric System Resource Units = Unidades de Trabajo del Sistema Metrico Decimal. K-12. Project C.A.M.B.I.O., Changing Attitudes towards Metrics for Bilingual Instruction & Operations.

    ERIC Educational Resources Information Center

    Pulido, Josefina; Almendares, Simon

    Four resource units are included in this document. For each, general objectives on knowledge and concepts, skills, and attitudes are given; content is outlined; and some suggestions for initiating the unit are listed. The first unit, on measuring length, provides six lesson plans, to teach about the meter, the smaller units of the meter, units…

  17. Wet and Wild: A Multidisciplinary Marine Education Teacher Guide, Grades K-6. Unit III. Research: Innerspace Explorers = Humedo y Salvaje. Tercera Unidad. La Investigacion Cientifica: Exploradores del Espacio Interior.

    ERIC Educational Resources Information Center

    Murphy, Richard C.

    Topics and activities related to oceanographic research (innerspace exploration) are the focus of this multidisciplinary, marine education teaching guide for students in kindergarten through grade 6. The guide is divided into six sections (labeled A through F). The first five sections consist of various kinds of activities, with the appropriate…

  18. Wet and Wild: A Multidisciplinary Marine Education Teacher Guide, Grades K-6. Unit II. Ocean Management: Who Owns the Sea? =Humedo y Salvaje. Segund Unidad. El Manejo de los Oceanos: Quien Es el Dueno de los Mares?

    ERIC Educational Resources Information Center

    Murphy, Richard C.

    Topics and activities related to ocean management are the focus of this multidisciplinary, marine education teaching guide for students in kindergarten through grade 6. The guide is divided into four sections (labeled A through D). The first three sections consist of various kinds of activities, with the appropriate grade levels (K-6, K-3, or 4-6)…

  19. Das Problem der Ubersetzbarkeit von Phraseologismen am Beispiel von Isabel Allendes Roman "Das Geisterhaus" (The Problem of the Translatability of Idioms using the Example of Isabel Allende's novel "The House of the Spirits").

    ERIC Educational Resources Information Center

    Cox, Luz

    1996-01-01

    Using the translation of Isabel Allende's novel "The House of the Spirits," this essay demonstrates that the mastery of a foreign language does not guarantee a translation true to the original. The Spanish of the Latin American countries exhibits numerous differences and does not always share a uniform vocabulary. Concrete measures are…

  20. Dermatomyositis: analysis of 109 patients surveyed at the Hospital das Clínicas (HCFMUSP), São Paulo, Brazil*

    PubMed Central

    Ortigosa, Luciena Cegatto Martins; dos Reis, Vitor Manuel Silva

    2014-01-01

    BACKGROUND Dermatomyositis affects striated muscles, skin and other organs. OBJECTIVE To characterize the disease from January 1992 to December 2002, assessing its classification, cutaneous and systemic manifestations, and also laboratory results, therapeutic and prognostic findings compared to those in the literature. METHODS Data were obtained from medical records of 109 patients who were classified into five groups: 23 juvenile dermatomyositis; 59 primary idiopathic dermatomyositis; 6 amyopathic dermatomyositis; 7 dermatomyositis associated with neoplasms and 14 dermatomyositis associated with other connective tissue diseases. RESULTS Sixty patients were classified as "definite" diagnosis; 33 as "possible"; four as "probable" and 12 and as amyopathic. The average age at diagnosis was 36 years. Cutaneous manifestations occurred in all patients; the most frequent symptom was loss of proximal muscle strength; the most common pulmonary disorder was interstitial lung disease, and gastritis was the most prevalent digestive manifestation. Tumors were documented in 6.42% of cases. Lactate dehydrogenase was the muscle enzyme most frequently elevated in the majority of cases. Skin biopsies were performed in 68 patients; muscle biopsies in 53; and electroneuromyographies in 58 patients. The most commonly used treatment was corticotherapy and the mortality rate was 14.7%. CONCLUSION in this sample, the disease appeared in younger individuals, was more frequent in women and the association with cancer was small. PMID:25184910

  1. Hepatologie Neuere Forschungsergebnisse in ihrer Bedeutung für das Verständnis von Leberkrankheiten

    NASA Astrophysics Data System (ADS)

    Gerok, W.; Blum, H. E.; Offensperger, W.; Offensperger, S.; Andus, T.; Groß, V.; Heinrich, P. C.

    1991-06-01

    By two exemplary clinical situations — acute viral hepatitis, acute-phase reaction of the liver — the significance of basic research for the understanding of clinical phenomena and for the development of new diagnostic and therapeutic procedures is demonstrated. The very different phenomena following infection with the hepatitis-B-virus can be explained by the variation in the interactions of virus and liver cell, by the immune reaction of the host, and by mutants of the virus. The reaction of the liver to an extrahepatic infection is mediated by interleukin-6, and characterized by an alteration in protein metabolism. The synthesis of acute-phase proteins is increased. The proteins confine the local injury and establish the homeostasis of the organism.

  2. Das Pinealorgan der Wirbeltiere: ein Modell für Untersuchungen von Rezeptor-und Effektormechanismen in neuronalen Systemen

    NASA Astrophysics Data System (ADS)

    Korf, Horst-W.; Wicht, Helmut

    1991-10-01

    Cell and molecular biological investigations have greatly contributed to our understanding of receptor and effector mechanisms in sensory, neuronal, and endocrine cells. A fascinating aspect of this line of research is how such mechanisms have evolved and how they interact with each other. As shown in this contribution, the vertebrate pineal organ is an interesting model to study these problems, because it undergoes a conspicuous transformation during phylogeny, comprises two well-chraracterized receptor mechanisms (photoreception and adrenoreception), and acts upon its targets via neuronal and neuroendocrine signals.

  3. Eventorientierte Veranstaltungen und Lebensqualität innenstädtischer Wohnbevölkerung. Das Beispiel Bamberg

    NASA Astrophysics Data System (ADS)

    Redepenning, Marc; Rhein, Niklas; Sauerwald, David

    2016-09-01

    Events do have, in addition to economic effects, impact on the quality of life of the affected population. Using a case study from the city of Bamberg this article addresses the subjective contentment with larger events. The results show variation in the range of contentment depending on age and time of residency in the city. Furthermore, it becomes obvious that the particular expectation on "life in the inner city" shapes the contentment. Cities should pay attention to this social heterogeneity when deploying strategies of revitalisation through festivals and events. They should take it seriously by using tools of collaborative planning to preserve the multi-functionality of inner cities.

  4. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... divided as sub-ACLs between limited access vessels, limited access vessels that are fishing under a... limited access fishery sub-ACLs for fishing years 2011 through 2013 are: (A) 2011: 24,954 mt. (B) 2012: 26... catch, observer set-aside, and research set-aside, as specified in this paragraph (a). The LAGC ACLs...

  5. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... divided as sub-ACLs between limited access vessels, limited access vessels that are fishing under a LAGC... adjustment. (i) The limited access fishery sub-ACLs for fishing years 2014 and 2015 are: (A) 2014: 18,885 mt...). (i) The ACLs for fishing years 2014 and 2015 for LAGC IFQ vessels without a limited access...

  6. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... divided as sub-ACLs between limited access vessels, limited access vessels that are fishing under a LAGC... adjustment. (i) The limited access fishery sub-ACLs for fishing years 2013 and 2014 are: (A) 2013: 19,093 mt... paragraph (a). (i) The ACLs for fishing years 2013 and 2014 for LAGC IFQ vessels without a limited...

  7. ExactDAS: an exact test procedure for the detection of differential alternative splicing in microarray experiments.

    PubMed

    Mary-Huard, Tristan; Jaffrezic, Florence; Robin, Stéphane

    2012-11-06

    The aim of this paper is to propose a test procedure for the detection of differential alternative splicing across conditions for tiling array or exon chip data. While developed in a mixed model framework, the test procedure is exact (avoiding computational burden) and applicable to a large variety of contrasts, including several previously published ones. A simulation study is presented to evaluate the robustness and performance of the method. It is found to have a good detection power of genes under differential alternative splicing, even for five biological replicates and four probes per exon. The methodology also enables the comparison of various experimental designs through exact power curves. This is illustrated with the comparison of paired and unpaired experiments. The test procedure was applied to two publicly available cancer data sets based on exon arrays, and showed promising results.

  8. Das Konstanzer Trainingsmodell (KTM) - Grundlagen und neue Entwicklungen (The Konstanz Training Model (KTM) -- Fundamental Principles and Recent Developments).

    ERIC Educational Resources Information Center

    Dann, Hanns-Dietrich; Humpert, Winfried

    2002-01-01

    Summarizes the Konstanz Training Model (KTM), a German primary and secondary preventive program that increases teacher self-competence and social competence in dealing with aggressive and disruptive student behaviors. Emphasizes KTM's focus on systemic aspects, cognitive level, and behavioral level approaches. Describes KTM Compact, a short term…

  9. Ökophysik: Plaudereien über das Leben auf dem Land, im Wasser und in der Luft

    NASA Astrophysics Data System (ADS)

    Nachtigall, W.

    Prof. em. Dr. rer. nat. Werner Nachtigall, geb. 1934, war als Zoophysiologe und Biophysiker Leiter des Zoologischen Instituts der Universität des Saarlandes in Saarbrücken. In Forschung und Ausbildung hat er sich insbesondere mit Aspekten der Technischen Biologie und Bionik befasst und mit seinen Forschergruppen viele Basisdaten insbesondere zur Ökologie, Physiologie und Physik des Fliegens und Schwimmens aber auch zur Stabilität beispielsweise der Gräser erarbeitet. Lebewesen überraschen immer wieder durch ihre "Biodiversität", ihre hochspezifischen Ausgestaltungen und Anpassungen.

  10. Neues "Francais fondamental?" Das Europa-Projekt "Un niveau seuil." (A New "Francais fondamental?" The European Project "A Threshold Level").

    ERIC Educational Resources Information Center

    Raasch, Albert

    1978-01-01

    The project "Threshold Level," initiated by the Council of Europe in 1976, is compared with "Francais fondamental," comparing their aims and their differences. Offered as an interim statement, the article leaves open the question of whether Francais fondamental should be replaced by the the Threshold Level. (IFS/WGA)

  11. DAsHER CD: Developing a Data-Oriented Human-Centric Enterprise Architecture for EarthCube

    NASA Astrophysics Data System (ADS)

    Yang, C. P.; Yu, M.; Sun, M.; Qin, H.; Robinson, E.

    2015-12-01

    One of the biggest challenges that face Earth scientists is the resource discovery, access, and sharing in a desired fashion. EarthCube is targeted to enable geoscientists to address the challenges by fostering community-governed efforts that develop a common cyberinfrastructure for the purpose of collecting, accessing, analyzing, sharing and visualizing all forms of data and related resources, through the use of advanced technological and computational capabilities. Here we design an Enterprise Architecture (EA) for EarthCube to facilitate the knowledge management, communication and human collaboration in pursuit of the unprecedented data sharing across the geosciences. The design results will provide EarthCube a reference framework for developing geoscience cyberinfrastructure collaborated by different stakeholders, and identifying topics which should invoke high interest in the community. The development of this EarthCube EA framework leverages popular frameworks, such as Zachman, Gartner, DoDAF, and FEAF. The science driver of this design is the needs from EarthCube community, including the analyzed user requirements from EarthCube End User Workshop reports and EarthCube working group roadmaps, and feedbacks or comments from scientists obtained by organizing workshops. The final product of this Enterprise Architecture is a four-volume reference document: 1) Volume one is this document and comprises an executive summary of the EarthCube architecture, serving as an overview in the initial phases of architecture development; 2) Volume two is the major body of the design product. It outlines all the architectural design components or viewpoints; 3) Volume three provides taxonomy of the EarthCube enterprise augmented with semantics relations; 4) Volume four describes an example of utilizing this architecture for a geoscience project.

  12. Bedeutung kleinräumiger Daten für die Evaluation von Bildungsprojekten. Das Beispiel der Junior Uni Wuppertal

    NASA Astrophysics Data System (ADS)

    Makles, Anna

    2016-12-01

    The Junior University, a University for children and youth in the city of Wuppertal, offers science courses that target children and youth from all socioeconomic backgrounds. The first evaluation study done by the University of Wuppertal in 2013 aimed at examining whether the Junior University has achieved this goal. The main challenge of our analysis was to approximate missing individual information on socioeconomic status by using spatial data. Therefore, we georeferenced address information of the Junior University students and linked those results to different characteristics available for about 2800 city blocks in the city of Wuppertal. We found out that indeed the Junior University succeeds in attracting children and youth from all socioeconomic backgrounds. The results show that many of the students live in poor neighborhoods or in neighborhoods with a high share of immigrants.

  13. Unternehmerische Verantwortung in der Stadt- und Regionalentwicklung. Einführung in das Themenheft "Corporate Regional Responsibility"

    NASA Astrophysics Data System (ADS)

    Kiese, Matthias; Schiek, Meike

    2016-03-01

    Firms assume increasing importance within co-operative modes of regional and urban governance. Further to just filling gaps left by the retreat of the welfare state, firms recognise the impact of their regional and local business environment on their performance, especially when it comes to attracting and retaining highly-skilled personnel. As an introduction to this issue, this contribution introduces the basic concept of corporate social responsibility and its regional variation, corporate regional responsibility.

  14. Fehler begehen - Mathematik verstehen Über die Bedeutung von Fehlern für das Verstehen

    NASA Astrophysics Data System (ADS)

    Käser, Udo

    Auch wenn eine historisch oder systematisch umfassende Darstellung zur Fehlerthematik bislang nicht vorliegt, ist die Idee, einer Fehleranalyse unter der Leitfrage, welche Fehler von Schülerinnen und Schülern aufgrund welcher epistemologischen Überzeugungen begangen werden, zentralen Raum für die Betrachtung von Verstehensprozessen einzuräumen, nicht neu. So ist es geradezu ein Charakteristikum einer modernen konstruktivistischen Didaktik, die eigenen Fehler von Lernenden als ihre individuellen Lerngelegenheiten zu begreifen, die einen wichtigen Motor für den subjektiven Lernfortschritt bilden. Diese Sichtweise wurzelt aus psychologischer Perspektive in Analysen in der Tradition Piagets, der in Abkehr von einer quantitativen, psychometrischen Beschreibung kognitiver Prozesse, wie sie sich zum Beispiel in Intelligenztheorien nach Binet findet, qualitativ zu beschreiben versuchte, in welcher Weise Kinder und Jugendliche denken und urteilen. Doch auch schon in der klassischen Philosophie sind entsprechende Ansätze zu finden. Prominente Beispiele hierfür sind die Idolenlehre Bacons und die Ideenlehre Platons.

  15. [231 laparoscopic cholecystectomy in ambulatory: what results?].

    PubMed

    Goulart, André; Delgado, Margarida; Antunes, Maria Conceição; Braga Dos Anjos, João

    2013-01-01

    Introdução: A colecistectomia laparoscópica é actualmente o gold standard no tratamento da patologia litiásica vesicular e colecistite aguda. A sua realização em regime de cirurgia de ambulatório permanece em discussão. O presente estudo tem por objectivo analisar a qualidade e segurança das colecistectomias laparoscópicas realizadas pela Unidade de Cirurgia de Ambulatório do Hospital de Braga e comparar os resultados com outros centros europeus que realizam colecistectomia laparoscópica em regime de ambulatório.Material e Métodos: Estudo observacional prospectivo de doentes submetidos a colecistectomia laparoscópica em regime de ambulatório durante 26 meses. Foram recolhidos dados referentes à demografia do doente, complicações peri e pós-operatórias, tempo cirúrgico e tempo de permanência no recobro e internamentos não programados.Resultados: Foram submetidos a colecistectomia laparoscópica em regime de ambulatório com pernoita (alta < 24h) 231 doentes. Três doentes tiveram intercorrências intra-operatórias com necessidade de conversão para laparotomia e quatro doentes foram internados após a cirurgia. O tempo médio de cirurgia foi de 58 minutos e o tempo médio de recobro de 19h19m. A morbilidade pósoperatória foi de 7,8% tendo, ocorrido dois internamentos não programados.Discussão: Uma das discussões que existe em torno da colecistectomia laparoscópica em regime de ambulatório é a necessidade de vigilância hospitalar durante a primeira noite após a cirurgia. Na nossa unidade, iniciamos a realização da colecistectomia laparoscópica em regime de ambulatório com pernoita hospitalar. Os resultados de mais de dois anos e 231 doentes operados a colecistectomia laparoscópica mostram que é uma técnica perfeitamente segura em regime de ambulatório.Conclusões: Os dados do estudo mostram que a colecistectomia laparoscópica é uma técnica segura em regime de ambulatório, com resultados semelhantes comparativamente com

  16. [Epidemiological study of place of death in Portugal in 2010 and comparison with the preferences of the Portuguese population].

    PubMed

    Gomes, Barbara; Sarmento, Vera P; Ferreira, Pedro Lopes; Higginson, Irene J

    2013-01-01

    Introdução: No contexto de um envelhecimento acentuado da população e aumento da mortalidade por doenças crónicas, este estudo epidemiológico nacional compara os locais onde as pessoas morrem com as preferências da população.Material e Métodos: Dados de óbitos em 2010 por género, grupo etário, região de residência (NUTS II) e local de morte (hospital/clínica, domicílio e outro), em pessoas com 16 anos ou mais, foram cedidos pelo Instituto Nacional de Estatística. Dados de preferências da população para local de morte obtiveram-se em 2010 através do inquérito telefónico PRISMA. Compara-se a distribuição de óbitos por local de morte com as preferências da população, segundo variáveis independentes, através de análise descritiva e inferencial.Resultados: Dos 105 471 óbitos que ocorreram em Portugal em 2010, 61,7% deram-se em hospitais/clínicas e 29,6% no domicílio. Dos 1 286 residentes em Portugal que participaram no inquérito PRISMA, 51,2% expressaram preferência por morrer em casa, 35,7% escolheram uma unidade de cuidados paliativos, 8,9% o hospital e 2,2% lar ou residência.Discussão e Conclusão: Existe um desfasamento substancial entre a realidade e preferências para local de morte em Portugal. Para ir ao encontro destas preferências é prioridade nacional desenvolver serviços de cuidados paliativos domiciliários, que previnam o aumento de óbitos hospitalares e que apoiem a morte em casa, com qualidade e respeitando preferências individuais. Recomenda-se a alteração das categorias de local de óbito no certificado oficial, com inclusão das opções ‘unidade de cuidados paliativos’ e ‘lar ou residência’, dado que as preferências dos cidadãos distinguem claramente entre estes locais.

  17. Simulação de ejeções de massa coronal

    NASA Astrophysics Data System (ADS)

    Corsini, M. A.; Silva, A. V. R.

    2003-08-01

    Ejeções de massa coronal (EMC) são bolhas gigantes de gás permeadas por campos magnéticos que são ejetadas do Sol durante um período de várias horas. Caso estas ejeções atinjam a Terra, geralmente, causam uma série de distúrbios às comunicações de longa distância e navegação, além de danos a satélites e transformadores. Portanto, é desejável que sejamos capazes de prever quando estas ejeções atingirão a Terra. Para tanto, é necessário um bom entendimento dos mecanismos causadores das ejeções e, principalmente, de como se dá a propagação das EMC e sua interação com o vento solar que permeia o meio interplanetário. Nesse sentido foi desenvolvido um programa computacional para resolver as equações MHD (Magneto-Hidro-Dinâmica) que regem a evolução das EMC. Primeiramente foram estabelecidas as condições necessárias para descrever o vento solar, no estado estacionário, que permeia todo o meio interplanetário. Num primeiro momento, resolveu-se o sistema de equações para o caso do vento isotérmico, conhecida como a solução de Parker, a fim de testarmos o modelo. Então, foi considerado o caso do vento solar com temperatura variável no meio interplanetário. Este resultado foi utilizado como a base de nosso sistema em seu instante inicial. Posteriormente foram feitas as considerações necessárias para descrever a propagação da Ejeção de Massa Coronal. As EMC foram simuladas como um aumento de densidade e temperatura local na coroa solar. A órbita e a posição da Terra foram incluídas no sistema. Os dados gerados possibilitaram uma análise da evolução da EMC pelo meio interplanetário até encontrar-se com a Terra. Os perfis de densidade e temperatura a 1 Unidade Astronômica são comparados com os dados de satélites reportados na literatura.

  18. [Biomarkers of cervical carcinogenesis associated with genital human papillomavirus infection].

    PubMed

    Oliveira, Ana; Delgado, Candida; Verdasca, Nuno; Pista, Angela

    2013-01-01

    dos oncogenes E6 e E7 está associada à progressão das lesões do colo do útero e apresenta maior especificidade no diagnóstico precoce das lesões pré-malignas. A quantificação do DNA dos HPVar pode ser um indicador promissor de prognóstico das lesões pré-neoplásicas do colo do útero.

  19. [Burnout in Portuguese Healthcare Professionals: An Analysis at the National Level].

    PubMed

    Marôco, João; Marôco, Ana Lúcia; Leite, Ema; Bastos, Cristina; Vazão, Maria José; Campos, Juliana

    2016-01-01

    Introdução: O burnout é uma síndrome psicológica, caracterizada por elevada exaustão emocional, elevada despersonalização e baixa realização profissional, que conduz à erosão dos valores pessoais, profissionais e de saúde. Este estudo reporta a prevalência do burnout em profissionais de saúde Portugueses. Material e Métodos: Os níveis de burnout foram estimados pelo Maslach Burnout Inventory - Human Services Survey numa escala ordinal de zero (nunca) a seis (sempre) pontos. A amostra foi constituída por 1 262 enfermeiros e 466 médicos com médias de idade de 36,8 anos (DP = 12,2) e 38,7 (DP = 11,0), respetivamente. Os participantes foram provenientes de todos os distritos nacionais (35% Lisboa; 18% Porto; 6% Aveiro, 6% Setúbal, 5% Coimbra; 5% regiões autónomas), com atuação em meio hospitalar (54%), centros de saúde (Unidade de Saúde Familiar - 30%; Unidades de Cuidados de Saúde Primários - 8%) e outras instituições públicas/privadas (8%). Resultados: A análise dos níveis de burnout revelou que ambas as categorias profissionais apresentaram níveis moderados a elevados de burnout (M = 3,0; DP = 1,7) não sendo significativas as diferenças entre as duas profissões. Vila Real (M = 3,8; SD = 1,7) e a Madeira (M = 2,5; DP = 1,5) são as regiões onde os níveis de burnout são mais e menos elevados, respetivamente. Os níveisde burnout não diferiram significativamente entre Hospitais, Unidades de Cuidados de Saúde Personalizados e Unidades de Saúde Familiares. Os profissionais com maior tempo na função são menos acometidos por burnout (r = -0,15) não ocorrendo associação significativa com a duração da jornada de trabalho (r = 0,04). A má qualidade das condições de trabalho foi o melhor preditor do burnout (r = -0,35). Discussão: A ocorrência da síndrome de burnout em profissionais de saúde portugueses é frequente, estando associada à percepção de más condições de trabalho e à menor duração do tempo de servi

  20. Tão perto de casa, tão longe de nós: etnografia das novas margens no centro da urbe

    PubMed Central

    Fernandes, Por Luís

    2011-01-01

    Philippe Bourgois é, desde 2007, “Richard Perry University professor” no Departamento de Antropologia e de Medicina Familiar e de Práticas Comunitárias na Universidade da Pensilvânia. Esteve durante largos anos ligado ao Departamento de Antropologia, História e Medicina Social da Universidade da Califórnia, São Francisco. A publicação, em 1995, de In Search of Respect: Selling Crack in El Barrio1 projectaria o seu nome muito para além dos Estados Unidos: uma etnografia no coração porto-riquenho do Harlem, em torno dos actores e dos ambientes da venda de crack. Seguir-se-ia um longo trabalho de terreno em acampamentos de dependentes de heroína em São Francisco, orientando o seu trabalho para as formas mais radicais da pobreza e da marginalidade nos EUA. É deste trabalho de terreno que sai o seu último livro, Righteous Dopefiend2. Em Junho de 2007 esteve em Lisboa para participar na 3.a edição do “Ethnografeast”. Foi então que aproveitámos a oportunidade para ouvir um percurso invulgar contado pelo próprio: uma longa conversa no Hotel Zurique, cujo nome só vem ao caso por evocar o país onde passou uma parte da infância. PMID:22013286

  1. Proceedings of the NATO Advanced Study Institute on Atmospheric Ozone: Its Variation and Human Influences, Aldeia das Acoteias, Algarve, Portugal, October 1-13, 1979,

    DTIC Science & Technology

    1980-05-01

    Form DOT F 1700.7 (8-7,’ Reproduction of completed page authorized PREFACE Fifty years ago, the first international conference on atmospheric ozone...dilemma was given by assuming that due to the rapid downward increase of the photochemical relaxation time from hours and days in the upper stratosphere to...of the (more rapid ) fluctuations in the 20 year Umkehr series overArosa (fig. 16)1 may be due to the fact that this goal could not always be reached

  2. Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) – short version

    PubMed Central

    Baron, Ralf; Binder, Andreas; Biniek, Rolf; Braune, Stephan; Buerkle, Hartmut; Dall, Peter; Demirakca, Sueha; Eckardt, Rahel; Eggers, Verena; Eichler, Ingolf; Fietze, Ingo; Freys, Stephan; Fründ, Andreas; Garten, Lars; Gohrbandt, Bernhard; Harth, Irene; Hartl, Wolfgang; Heppner, Hans-Jürgen; Horter, Johannes; Huth, Ralf; Janssens, Uwe; Jungk, Christine; Kaeuper, Kristin Maria; Kessler, Paul; Kleinschmidt, Stefan; Kochanek, Matthias; Kumpf, Matthias; Meiser, Andreas; Mueller, Anika; Orth, Maritta; Putensen, Christian; Roth, Bernd; Schaefer, Michael; Schaefers, Rainhild; Schellongowski, Peter; Schindler, Monika; Schmitt, Reinhard; Scholz, Jens; Schroeder, Stefan; Schwarzmann, Gerhard; Spies, Claudia; Stingele, Robert; Tonner, Peter; Trieschmann, Uwe; Tryba, Michael; Wappler, Frank; Waydhas, Christian; Weiss, Bjoern; Weisshaar, Guido

    2015-01-01

    In 2010, under the guidance of the DGAI (German Society of Anaesthesiology and Intensive Care Medicine) and DIVI (German Interdisciplinary Association for Intensive Care and Emergency Medicine), twelve German medical societies published the “Evidence- and Consensus-based Guidelines on the Management of Analgesia, Sedation and Delirium in Intensive Care”. Since then, several new studies and publications have considerably increased the body of evidence, including the new recommendations from the American College of Critical Care Medicine (ACCM) in conjunction with Society of Critical Care Medicine (SCCM) and American Society of Health-System Pharmacists (ASHP) from 2013. For this update, a major restructuring and extension of the guidelines were needed in order to cover new aspects of treatment, such as sleep and anxiety management. The literature was systematically searched and evaluated using the criteria of the Oxford Center of Evidence Based Medicine. The body of evidence used to formulate these recommendations was reviewed and approved by representatives of 17 national societies. Three grades of recommendation were used as follows: Grade “A” (strong recommendation), Grade “B” (recommendation) and Grade “0” (open recommendation). The result is a comprehensive, interdisciplinary, evidence and consensus-based set of level 3 guidelines. This publication was designed for all ICU professionals, and takes into account all critically ill patient populations. It represents a guide to symptom-oriented prevention, diagnosis, and treatment of delirium, anxiety, stress, and protocol-based analgesia, sedation, and sleep-management in intensive care medicine. PMID:26609286

  3. Die regionalökonomische Bedeutung der Wissenschaft für das Ruhrgebiet. Hochschulen und außeruniversitäre Forschungseinrichtungen als Motor der regionalen Entwicklung

    NASA Astrophysics Data System (ADS)

    Kriegesmann, Bernd; Böttcher, Matthias; Lippmann, Torben

    2016-09-01

    The Ruhr area has advanced to the largest university region in Germany - often unnoticed within and outside. At the same time scientific institutions have become a major economic factor. Because of the higher and extra-university research institutions about 2.5 billion euros are effective as a demand potential in the region. 1.7 billion euros of this amount are directly associated with investments and operating expenditures of the scientific institutions as well as consumptions of employees and students. Additional 770 million euros result in revenues of many branches such as trade, housing, gastronomy sector, handcraft industry etc. It should not be underestimated that higher and extra-university research institutions generate with their research activities particular funding from the European Union or the rest of Germany for benefit of the region. Each euro spent by the state government for basic funding creates 39 cents third-party funding. These regional-economic effects result in noticeable employment impacts within the region. Around 25,000 people are directly employed in higher and extra-university research institutes or student unions (Studierendenwerke), about 22,000 jobs in other economic sectors are ensured or created by the induced demand. Science has thus become an important economic factor and represents an essential counterbalance to employment decline in shrinking industries of the region. The specific inclusion of science in a regional development strategy and targeted relining with appropriate measures to strengthen the science creates therefore an effective starting point for the design of structural change.

  4. Immunodetection of Triticum mosaic virus by DAS- and DAC-ELISA using antibodies produced against coat protein expressed in Escherichia coli: potential for high-throughput diagnostic methods.

    PubMed

    Tatineni, Satyanarayana; Sarath, Gautam; Seifers, Dallas; French, Roy

    2013-04-01

    Triticum mosaic virus (TriMV), an economically important virus infecting wheat in the Great Plains region of the USA, is the type species of the Poacevirus genus in the family Potyviridae. Sensitive and high-throughput serology-based detection methods are crucial for the management of TriMV and germplasm screening in wheat breeding programs. In this study, TriMV coat protein (CP) was expressed in Escherichia coli, and polyclonal antibodies were generated against purified soluble native form recombinant CP (rCP) in rabbits. Specificity and sensitivity of resulting antibodies were tested in Western immuno-blot and enzyme-linked immunosorbent assays (ELISA). In direct antigen coating (DAC)-ELISA, antibodies reacted specifically, beyond 1:20,000 dilution with TriMV in crude sap, but not with healthy extracts, and antiserum at a 1:10,000 dilution detected TriMV in crude sap up to 1:4860 dilution. Notably, rabbit anti-TriMV IgG and anti-TriMV IgG-alkaline phosphatase conjugate reacted positively with native virions in crude sap in a double antibody sandwich-ELISA, suggesting that these antibodies can be used as coating antibodies which is crucial for any 'sandwich' type of assays. Finally, the recombinant antibodies reacted positively in ELISA with representative TriMV isolates collected from fields, suggesting that antibodies generated against rCP can be used for sensitive, large-scale, and broad-spectrum detection of TriMV.

  5. Grüne Infrastruktur in den Städten Nordrhein-Westfalens. Bedeutung als Standortfaktor und Einfluss auf das Standortmarketing

    NASA Astrophysics Data System (ADS)

    Schäffer, Ina

    2016-06-01

    Hardly any other city in North Rhine-Westphalia has such a green image as the city of Münster. It embodies the image of a livable city in Germany. Other North Rhine-Westphalian cities also work on their external perception and are approaching the task of getting a greener image for themselves in many ways. A central question is how it is done precisely and whether urban green infrastructure can be a locational factor to affect location-based marketing. This article deals with the strategies of various cities in North Rhine-Westphalia.

  6. Folgen des Globalen Wandels für das Grundwasser in Süddeutschland - Teil 2: Sozioökonomische Aspekte

    NASA Astrophysics Data System (ADS)

    Barthel, Roland; Krimly, Tatjana; Elbers, Michael; Soboll, Anja; Wackerbauer, Johann; Hennicker, Rolf; Janisch, Stephan; Reichenau, Tim G.; Dabbert, Stephan; Schmude, Jürgen; Ernst, Andreas; Mauser, Wolfram

    2011-12-01

    In order to account for complex interactions between humans climate and the water cycle, the research consortium GLOWA-Danube (www.glowa-danube.de) has developed the simulation system DANUBIA which consists of 17 coupled models. DANUBIA was applied to investigate various impacts of global-change between 2011 and 2060 in the Upper Danube Catchment. This article describes part 2 of an article series with investigations of socio-economic aspects, while part 1 (Barthel et al. in Grundwasser 16(4), doi:10.1007/s007-011-01794, 2011) deals with natural-spatial aspects. The principles of socio-economic actor-modeling and interactions between socio-economic and natural science model components are described here. We present selected simulations that show impacts on groundwater from changes in agriculture, tourism, economy, domestic water users and water supply. Despite decreases in water consumption, the scenario simulations show significant decreases in groundwater quantity. On the other hand, groundwater quality will likely be influenced more severely by land use changes compared to direct climatic causes. However, overall changes will not be dramatic.

  7. Folgen des Globalen Wandels für das Grundwasser in Süddeutschland - Teil 1: Naturräumliche Aspekte

    NASA Astrophysics Data System (ADS)

    Barthel, Roland; Reichenau, Tim G.; Muerth, Markus; Heinzeller, Christoph; Schneider, Karl; Hennicker, Rolf; Mauser, Wolfram

    2011-12-01

    In order to account for complex interactions between humans climate and the water cycle, the research consortium GLOWA-Danube (www.glowa-danube.de) has developed the simulation system DANUBIA which consists of 17 coupled models. DANUBIA was applied to investigate various impacts of global-change between 2011 and 2060 in the Upper Danube Catchment. This article represents part 1 of an article series and describes groundwater and natural aspects of the investigations, while part 2 describes socio-economic aspects (Barthel et al. in Grundwaser 16(4), doi:10.1007/s00767-011-0180-y, 2011). Here we describe concepts of GLOWA-Danube and DANUBIA as well as groundwater-related model components. This leads to selected simulation results for water balance, groundwater quantity and quality. The chosen scenarios show decreasing precipitation, increasing temperatures, and changes in the annual distribution that lead to significant decreases in groundwater recharge. Regional predictions of groundwater quality were difficult to achieve because of complex soil and groundwater processes. However, climatic change will probably have little impact.

  8. Axisymmetric rotational stagnation point flow impinging radially a permeable stretching/shrinking surface in a nanofluid using Tiwari and Das model.

    PubMed

    Roşca, Natalia C; Pop, Ioan

    2017-01-12

    In this paper, the problem of normal impingement rotational stagnation-point flow on a radially permeable stretching sheet in a viscous fluid, recently studied in a very interesting paper, is extended to a water-based nanofluid. A similarity transformation is used to reduce the system of governing nonlinear partial differential equations to a system of ordinary differential equations, which is then solved numerically using the function bvp4c from Matlab. It is found that dual (upper and lower branch) solutions exist for some values of the governing parameters. From the stability analysis, it is found that the upper branch solution is stable, while the lower branch solution is unstable. Sample velocity and temperature profiles along both solution branches are graphically presented.

  9. Das Bin Ich. Ein Buch von mir uber mich (It's Me! A Book By and About Myself). Communicative Activities for German Immersion and Second Language Classes.

    ERIC Educational Resources Information Center

    Wicke, Mariele; Wicke, Rainer

    This workbook is intended as a text for the learner of German as a foreign language. The workbook is complete with exercises that require students to provide information about themselves. Students provide information by reading questions and filling in the blanks. Questions are asked about families, friends, likes and dislikes, hobbies, and even…

  10. Kooperatives Lernen lernen? Zur Diskussion uber das Bildungswesen in Japan (Learning Cooperative Learning? On the Discussion of the Japanese Educational System).

    ERIC Educational Resources Information Center

    Schubert, Volker

    1998-01-01

    Suggests a reconsideration of the criticism of Japanese competition against the background of the Japanese educational system's highly developed learning culture. Considers some of the basic aspects of group-oriented communal learning in school, while also cautioning against a "monocausal" culturalism. (Author/CMK)

  11. Lemaître, the expanding universe, and the cosmological constant (German Title: Lemaître, das expandierende Universum und die kosmologische Konstante )

    NASA Astrophysics Data System (ADS)

    Roessler, Kurt

    The scientific and human relations of Albert Einstein and Georges Lemaître are discussed. In 1927 the later had interpreted the general theory of relativity for a model of an expanding cosmos using a positive value of the cosmological constant. In the three open questions between them: expansion of cosmos, primordial state of a quantum vacuum (``primeval atom''), importance of the cosmological constant for vacuum energy, Lemaître finally won over the heavily opposing Einstein. The philosophical and ontological tendency of Einstein's thinking was contrasted with the strict epistemological line of the catholic priest Lemaître. The dramatic changes between friendship and controversy finally led to a diminution of Lemaître's reputation as ``Darwin of Cosmology''. In that case, the late Einstein proved to be a hindrance rather than a promoter of evolution in cosmology.

  12. Molecular characterization of van genes found in vancomycin-resistant Enterococcus spp. isolated from the Hospital das Clínicas, FMUSP, São Paulo, Brazil.

    PubMed

    Caiaffa Filho, H H; Almeida, G D; Oliveira, G A; Sarahyba, L; Mamizuka, E M; Burattini, M N

    2003-06-01

    Vancomycin-resistant enterococci strains (VRE) is an important pathogen related with hospital infections in many countries, presenting limited or no therapeutic options for treating serious infections. VRE has presented some different genotypes been VanA and VanB considered to be the most important in hospital environments. In the present study the authors investigated the prevalence of van genes (A, B an C) among clinical isolates of VRE in a five month period at a large tertiary hospital in Sao Paulo, Brazil. The results showed the presence of vanA, but not vanB or vanC in all 43 strains of E. faecalis and five E. faecium studied. The results bring an important issue, due to the possibility of resistance spread of vanA genes, to be monitored and solved by the hospital infection control team and the microbiology and molecular biology laboratories at tertiary Hospitals.

  13. Längengrad. Die wahre Geschichte eines einsamen Genies, welches das größte wissenschaftliche Problem seiner Zeit löste.

    NASA Astrophysics Data System (ADS)

    Sobel, D.

    This book is a German translation, by M. Fienbork, from the American original "Longitude", published in 1995. It tells the story of John Harrison (1693 - 1776), the inventor of a chronometer for precise time determination onboard of ships.

  14. Das Blüte-Bestäuber-Netz auf Brachflächen : biozönologische Untersuchung zur Bedeutung von Brachen in einer intensiv genutzten Agrarlandschaft

    NASA Astrophysics Data System (ADS)

    Hahn, Robert

    2002-11-01

    In der vorliegenden Dissertation wird die Bedeutung von Brachen für Artenvielfalt und Stabilität von Blüte-Bestäuber-Nahrungsnetzen in agrarisch genutzten Landschaften anhand ausgewählter blütenbesuchender Insektengruppen (Syrphidae, Lepidoptera) untersucht. Die Freilandarbeiten fanden von 1998-2000 im Raum der Feldberger Seenlandschaft, Mecklenburg-Vorpommern, statt. Es werden die beiden Hauptnahrungsquellen Nektar und Pollen betrachtet, dabei fanden Untersuchungen zur Intensität der Blüte-Bestäuber-Interaktion auf Stilllegungsflächen, zum flächenbezogenen quantitativen Nektarangebot im Jahresverlauf, zur individuellen Pollennutzung bei Syrphiden und zur Breite und Überlappung der Nahrungsnischen bei den dominanten Arten Episyrphus balteatus, Metasyrphus corollae, Syritta pipiens und Sphaerophoria scripta statt. Im Ergebnis zeigt sich eine hohe Bedeutung der Brachflächen für die Stabilität des Blüte-Bestäuber-Netzes, während die Diversität von anderen, eher landschaftsbezogenen Faktoren abhängig ist. This dissertation examines the importance of fallow land for the diversity and stability of pollination webs in agricultural landscapes as exemplified by selected groups of anthophilous insects (syrphidae and lepidoptera). The field studies were carried out between 1998 and 2000 in the Feldberg lakeland area in the north-east German State of Mecklenburg-Western Pomerania. Observations were made of nectar and pollen as the two main sources of food. Studies were conducted into the intensity of plant-pollinator interaction in set-aside areas, the site-specific quantity of nectar available during the vegetation period and the individual pollen intake of syrphid flies. Different methods were employed to establish the breadth of the trophic niches among the predominant species (Episyrphus balteatus, Metasyrphus corollae, Syritta pipiens and Sphaerophoria scripta) and the extent to which they overlapped. The studies showed that, while fallow land is very important for the stability of plant-pollinator food webs, their diversity depends on other factors that are more closely related to the landscape.

  15. Axisymmetric rotational stagnation point flow impinging radially a permeable stretching/shrinking surface in a nanofluid using Tiwari and Das model

    NASA Astrophysics Data System (ADS)

    Roşca, Natalia C.; Pop, Ioan

    2017-01-01

    In this paper, the problem of normal impingement rotational stagnation-point flow on a radially permeable stretching sheet in a viscous fluid, recently studied in a very interesting paper, is extended to a water-based nanofluid. A similarity transformation is used to reduce the system of governing nonlinear partial differential equations to a system of ordinary differential equations, which is then solved numerically using the function bvp4c from Matlab. It is found that dual (upper and lower branch) solutions exist for some values of the governing parameters. From the stability analysis, it is found that the upper branch solution is stable, while the lower branch solution is unstable. Sample velocity and temperature profiles along both solution branches are graphically presented.

  16. [Hospitalizations at Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, USP, 1996-2003].

    PubMed

    Chaves, Lucieli Dias Pedreschi; Laus, Ana Maria; Anselmi, Maria Luiza

    2009-03-01

    Hospitalizations represent an important share of healthcare, due to both the complexity of actions and the financial volume applied. This descriptive-exploratory investigation had the purpose to identify and describing the physical and financial production of hospitalizations performed in a school hospital in the state of São Paulo, from 1996 to 2003, focusing the specialties of surgical clinic, medical clinic, pediatrics and obstetrics. Data collection was performed by searching the official databanks of the studied institution. In that period, a global 8.5% reduction in the frequency of admittances and a 78.4% increase in the financial resources were observed. Surgical clinic, with more expensive procedures, increased its admittances; the production in obstetrics showed the lowest variation. The increasing incorporation of technology, the demands from regional users and the migration of users from the supplementary system to the SUS may justify the variation of production in the different specialties.

  17. Comment on `Magnitude conversion problem using general orthogonal regression' by H. R. Wason, Ranjit Das and M. L. Sharma, (Geophys. J. Int., 190, 1091-1096)

    NASA Astrophysics Data System (ADS)

    Gasperini, Paolo; Lolli, Barbara

    2014-01-01

    The argument proposed by Wason et al. that the conversion of magnitudes from a scale (e.g. Ms or mb) to another (e.g. Mw), using the coefficients computed by the general orthogonal regression method (Fuller) is biased if the observed values of the predictor (independent) variable are used in the equation as well as the methodology they suggest to estimate the supposedly true values of the predictor variable are wrong for a number of theoretical and empirical reasons. Hence, we advise against the use of such methodology for magnitude conversions.

  18. Axisymmetric rotational stagnation point flow impinging radially a permeable stretching/shrinking surface in a nanofluid using Tiwari and Das model

    PubMed Central

    Roşca, Natalia C.; Pop, Ioan

    2017-01-01

    In this paper, the problem of normal impingement rotational stagnation-point flow on a radially permeable stretching sheet in a viscous fluid, recently studied in a very interesting paper, is extended to a water-based nanofluid. A similarity transformation is used to reduce the system of governing nonlinear partial differential equations to a system of ordinary differential equations, which is then solved numerically using the function bvp4c from Matlab. It is found that dual (upper and lower branch) solutions exist for some values of the governing parameters. From the stability analysis, it is found that the upper branch solution is stable, while the lower branch solution is unstable. Sample velocity and temperature profiles along both solution branches are graphically presented. PMID:28079124

  19. Mājsaimniecību Ietekme uz Klimatu Latvijā: Oglekļa Pēdas Rādītājs

    NASA Astrophysics Data System (ADS)

    Brizga, J.; Kudreņickis, I.

    2009-01-01

    People more and more recognize climate change as one of the main environmental problems and the term `carbon footprint' (CF) has become popular and is now in widespread use. In this paper, the CF concept has been applied to analyse average per capita household Greenhouse Gas (GHG) emissions in Latvia. We explore household CF in housing (heating and electricity consumption), transport, food and goods and service sectors, which are the main household environmental pressure areas. This paper provides an understanding of both direct and indirect (embodied) GHG emissions. Results from the study suggest that the average Latvian exceeds its global fair share of GHG emissions - the average per capita GHG in 2006 was 4.35 t CO2e. The highest household emissions arise from housing (37%), mobility (26%) and food consumption (25%), goods and services together account only for 12% of total household GHG emissions. This study, however, does not cover capital investments in infrastructure (roads, public buildings etc.) which could increase total emission by almost a ton. The study emphasizes that attention must be paid to the lifestyles, infrastructure and institutions that result in considerable amounts of carbon being locked up in the household activities through which people meet their everyday needs. The findings also indicate that policies should be targeted at the segments in society responsible for the highest carbon footprints, ie. housing, food and mobility.

  20. Antarktis: Das CCAMLR-Übereinkommen (Convention on the Conservation of Antarctic Marine Living Resources) und die illegale Überfischung der südlichen Ozeane

    NASA Astrophysics Data System (ADS)

    Siegel, Volker

    1999-12-01

    The Convention for the Conservation of Antarctic Marine Living Resources (CCAMLR) was ratified in 1982. This Convention was established in the light of a rapidly developing krill fishery in the 1970’s. The objectives of the Convention are the rational use of marine living resources as well as the conservation of the resources and the marine ecosystem. Establishing the principle of the ecosystem approach has been rather progressive in fisheries conventions. From the bery beginning CCAMLR had to deal with problems of over-exploited fish stock from the unregulated fishery of pre-CCAMLR times. Antarctic cod and icefish stock were already heavily harvested or even showed signs of overfishing. Conservation measures and the closure of subareas for several years did not always lead to satisfactorily results. While some stock of icefish recovered to the extent, that a new fishery on a low level could be re-opened, other icefish stocks and especially Antarctic cod stocks have not recovered from this early depletion. A new dimension in the fishery developed in the mid 1990’s, when very conservative conservation measures were introduced for the Dissostichus (toothfish), but due to the high commercial value a large illegal fishery developed rapidly in the Convention area. One additional problem of managing the longline fishery for toothfish is the by-catch and incidental mortality of sea-birds, for which special measures were established to avoid sea-bird mortality. The compliance with the measures and the elimination of the illegal fishery require strong actions of the Commission, the political decision-making body of CCAMLR. A future challange for CCAMLR could be the potentially expanding krill fishery. In the understanding of a precautionary approach, the scientific body of CCAMLR has already started to collect biological data and develop management and monitoring models for this fishery.

  1. An analysis of seasonal changes in STE using measurements from the TOPSE campaign and the Beryllium-7 distribution from a calculation driven by the GEOS-3 DAS.

    NASA Astrophysics Data System (ADS)

    Allen, D. J.; Dibb, J. E.; Ridley, B.; Pickering, K. E.

    2002-05-01

    Measurements of tropospheric ozone (O3) between 30\\deg and 70\\deg N show springtime maxima at remote locations. The contribution of seasonal changes in stratosphere-troposphere exchange (STE) to these maxima was investigated using measurements from the Tropospheric Ozone Production about the Spring Equinox Experiment (TOPSE) campaign and the Beryllium-7 (7Be) distribution from a calculation driven by fields from the Goddard Earth Observing System Data Assimilation System. Comparison with TOPSE measurements revealed that upper tropospheric model-calculated 7Be mixing ratios were reasonable (a change from previous calculations) but that lower tropospheric mixing ratios were too low most likely due to an overestimation of scavenging. Temporal fluctuations were well captured although their amplitudes were often underestimated. Analysis of O3 measurements indicated that mixing ratios increased by 5-10% per month for θ < 300 K (the underworld) and by 10-15% per month for θ > 300 K (the tropospheric middleworld). 7Be mixing ratios decreased with time for θ < 290 K and increased with time for θ > 300 K. Model-calculated middleworld increases of 7Be were a factor of 2 less than measured increases. 7Be with a stratospheric source (strat-7Be) increased by 4.6-8.8% along TOPSE flight paths within the tropospheric middleworld. Increases in strat-7Be were not seen along TOPSE flight paths in the underworld. Assuming changes in O3 with a stratospheric source are the same as changes in strat-7Be and that 50% of O3 is produced in the stratosphere, changes in STE explain 20-60% of O3 increases in the tropospheric middleworld and less than 30% of O3 increases in the underworld.

  2. Elektroninės cigaretės: naujas būdas mesti rūkyti ar nauja grėsmė?

    PubMed Central

    Aistė, Aleknaitė; Monika, Andrijauskaitė; Justė, Latauskienė; Viktorija, Andrejevaitė

    2016-01-01

    Nuo 2010 m. tarp suaugusiųjų ir paauglių išaugo elektroninių cigarečių vartojimas. Dauguma el. cigarečių vartotojų anksčiau yra rūkę tradicinius tabako gaminius. Didžioji dalis žmonių el. cigaretes suvokia kaip priemonę, padėsiančią mesti rūkyti ar sumažinti surūkomų įprastinių cigarečių kiekį. Elektroninės cigaretės yra prietaisas, susidedantis iš skysčiu užpildytos kasetės, kaitiklio bei baterijos. Nuspaudus mygtuką įjungiamas kaitiklis, kuris šildo skystį, o, šiam tapus garais, jie įkvepiami. Visų rūšių el. skysčių pagrindinės sudedamosios dalys yra glicerolis arba propileno glikolis, papildomai gali būti pridedama nikotino ir / ar aromatų. Skysčiuose taip pat nustatyta įvairių kitų cheminių medžiagų. Ilgalaikio el. cigarečių vartojimo pasekmės sveikatai nėra išaiškintos, manoma, kad jos turėtų būti saugesnės nei rūkyti įprastines cigaretes. Nėra pakankamai ištirtas el. cigarečių skysčiuose esančių medžiagų toksiškumas. Trūksta duomenų apie el. cigarečių, kaip pagalbinės priemonės norint mesti rūkyti, veiksmingumą ir saugumą. Gydytojas norinčiam mesti rūkyti pacientui pirmiausia turėtų pasiūlyti patvirtintas pakaitinės nikotino terapijos ar kitas pagalbines priemones ir užtikrinti, kad pacientas gautų informaciją apie naujausius medikamentus, galinčius jam padėti. Jei pacientas atsisako šių priemonių ir renkasi el. cigaretes, gydytojas turėtų informuoti apie abejotiną jų saugumą ir veiksmingumą. Visuomenėje kyla susirūpinimas, kad el. cigarečių rūkymas gali paskatinti priklausomybę nikotinui ir padidinti norą išbandyti įprastines cigaretes. Nerimą kelia ir neapribotas el. cigarečių vartojimas viešosiose vietose. Nėra žinoma, kokią įtaką aplinkinių sveikatai gali turėti pasyvus garinimas. El. cigarečių reglamentavimas visame pasaulyje skiriasi ir laikui bėgant kinta. PMID:28356791

  3. [Autism and Early Neurodevelopmental Milestones].

    PubMed

    Ferreira, Xavier; Oliveira, Guiomar

    2016-03-01

    Introdução: A perturbação do espectro do autismo, neste texto também designada por autismo, é uma patologia crónica do neurodesenvolvimento, que se manifesta precocemente na infância por alterações da interação social, comunicação e comportamento repetitivo. Não estando disponíveis biomarcadores específicos, o diagnóstico baseia-se exclusivamente na avaliação clínica. O objetivo deste estudo é verificar quais os marcadores precoces do desenvolvimento psicomotor ou neurodesenvolvimento, que se correlacionam significativamente com a gravidade da clínica central do autismo, quocientes de desenvolvimento e com a função adaptativa. Material e Métodos: Procedemos ao estudo retrospetivo de uma população de 1 572 indivíduos com o diagnóstico de autismo seguidos na Unidade de Neurodesenvolvimento e Autismo do Centro de Desenvolvimento da Criança do Hospital Pediátrico do Centro Hospitalar e Universitário de Coimbra. Analisámos seis marcadores precoces do desenvolvimento psicomotor: idades de aquisição 'da marcha', 'das primeiras palavras', 'das primeiras frases', 'do controlo de esfíncter vesical diurno', 'do controlo de esfíncter vesical noturno' e de início das primeiras queixas. Posteriormente dividimos a amostra em três subgrupos de gravidade clínica segundo a escala Childhood Autism Rating Scale e pesquisamos diferenças significativas entre os três subgrupos relativamente aos seis marcadores definidos. Resultados: O marcador 'idade de aquisição das primeiras frases' foi, de entre os seis, aquele que se correlacionou mais fortemente com as variáveis da clínica de autismo, quocientes de desenvolvimento/inteligência e comportamento ou função adaptativa. Na divisão da amostra em subgrupos de gravidade clínica, foi o de maior gravidade que mostrou idades de aquisição dos marcadores do neurodesenvolvimento mais tardias e idades mais precoces de manifestação das primeiras queixas. Discussão: Este estudo vem demonstrar a

  4. [Pharmacovigilance in Portugal: Activity of the Central Pharmacovigilance Unit].

    PubMed

    Batel-Marques, Francisco; Mendes, Diogo; Alves, Carlos; Penedones, Ana; Dias, Patricia; Martins, Angelina; Santiago, Luiz Miguel; Fontes-Ribeiro, Carlos; Caramona, Margarida; Macedo, Tice

    2015-01-01

    Introdução: Caracterizar as notificações espontâneas de eventos adversos a medicamentos recebidas pela Unidade de Farmacovigilância do Centro.Material e Métodos: Consideraram-se todas as notificações reportadas entre 01/2001 e 12/2013. Estimaram-se taxas de notificação anuais. Os casos foram caracterizados quanto à gravidade, conhecimento prévio, causalidade imputada, origem e grupo profissional do notificador, tipo de evento adverso e grupos farmacoterapêuticos onde se incluem os medicamentos suspeitos com maior prevalência de notificação.Resultados: A Unidade recebeu 2408 notificações, que continham 5749 eventos adversos. No ano de 2013 foi registada uma taxa de notificação de 171 notificações/milhão de habitantes. Do total de notificações, 55% foram classificadas como graves. Das notificações com causalidade imputada, 90% tinham uma relação pelo menos possível com o medicamento suspeito. Os medicamentos que originaram maior número de notificações foram os anti-infeciosos para uso sistémico (n = 809; 33%), e os eventos adversos mais frequentemente notificados foram as âÄúAfeções dos tecidos cutâneos e subcutâneosâÄù (n = 1139; 20%). Registaram-se 154 (6,4%) casos de risco de vida e/ou morte e 88 (3,6%) continham pelo menos um evento adverso classificado simultaneamente como grave, desconhecido e definitivo ou provável.Discussão: Os resultados deste estudo são consistentes com os de outros estudos, designadamente no que diz respeito à gravidade, aos grupos farmacoterapêuticos onde se incluem os medicamentos suspeitos e aos tipos de eventos adversos reportados.Conclusão: Ao longo do período avaliado, a UFC solidificou a sua atividade, tendo verificado um crescimento da taxa de notificação em geral e um aumento da notificação de reações adversas graves e desconhecidas.

  5. [Relationship between smoking and anxiety and depression in primary care].

    PubMed

    Farinha, Helder; Raposo de Almeida, Joana; Aleixo, Ana Rita; Oliveira, Hugo; Xavier, Filomena; Santos, Ana Isabel

    2013-01-01

    Introdução: A prevalência de tabagismo em Portugal é estimada em 19,7% (2005). O tabagismo é prevalente nas perturbações da ansiedade. Alguns estudos referem que 60% dos fumadores tem história de depressão. A dependência tabágica pode ser avaliada pela escala de Fagerström. A Escala de Ansiedade e Depressão Hospitalar permite estimar a ansiedade e depressão. O objectivo deste trabalho foi procurar a existência de relação entre tabagismo e ansiedade/depressão em utentes de oito unidades de cuidados primários.Material e Métodos: Foi desenhado um estudo observacional, descritivo, transversal, analítico. Inquérito anónimo. Foram considerados como critérios de inclusão os utilizadores das unidades, maiores de 18 anos e alfabetizados e de exclusão os menores de 18 anos ou erros no preenchimento dos inquéritos. As variáveis consideradas foram: Fagerström, Escala de Ansiedade e Depressão Hospitalar, idade, estado civil, género, profissão, escolaridade.Resultados: Foram considerados no estudo um total de 608 indivíduos, sendo 64% do género feminino e 21% de fumadores. Não verificámos diferenças em termos de ansiedade ou depressão na comparação entre não fumadores, ex-fumadores e fumadores. Verificámos que o grau de dependência da nicotina varia directamente com a ansiedade e depressão embora só se encontre relação estatisticamente significativa no género feminino, mesmo após correcção do efeito da idade.Discussão: Existe relação entre dependência da nicotina e gravidade de sintomas de ansiedade e depressão, sobretudo no género feminino. Limitação: viés de selecção.Conclusão: Este estudo fornece informação relativa aos factores psicológicos associados ao consumo de tabaco, podendo ser útil no tratamento da dependência de nicotina.

  6. [Mini-Mental State Examination: Screening and Diagnosis of Cognitive Decline, Using New Normative Data].

    PubMed

    Santana, Isabel; Duro, Diana; Lemos, Raquel; Costa, Vanessa; Pereira, Miguel; Simões, Mário R; Freitas, Sandra

    2016-04-01

    Introdução: O Mini-Mental State Examination é o teste de rastreio de défice cognitivo/demência mais difundido. No nosso país têm-se utilizado pontuações de corte definidas por grupos de literacia, mas existem novas propostas sustentadas por estudos mais representativos. Propomo-nos confirmar a influência da idade e da escolaridade no desempenho, avaliar a capacidade discriminativa dos novos dados normativos e testar a acuidade diagnóstica das pontuações de corte validadas para o défice cognitivo ligeiro e para as formas mais prevalentes de demência. Material e Métodos: O estudo incluiu 1 441 participantes escolarizados, divididos em sete subgrupos: Défice cognitivo ligeiro, doença de Alzheimer, demência fronto-temporal, demência vascular, demência com corpos de Lewy, controlo-comunidade e controlo-clínica- memória. Resultados: Em conjunto, idade e escolaridade explicam 10,4% da variância dos resultados no Mini-Mental State Examination, com ambas contribuindo significativamente para a predição dos resultados. A acuidade diagnóstica com base nos dados normativos mais recentes foi sempre superior à conseguida com as pontuações de corte de validação, revelando uma especificidade excelente (superior a 90%) e uma sensibilidade também excelente para a doença de Alzheimer ligeira (91%), boa para demência com corpos de Lewy (78%), baixa para o défice cognitivo ligeiro (65%) e demência fronto-temporal e demência vascular (55%). Discussão e Conclusões: O desempenho no Mini-Mental State Examination é influenciado pela idade e pela escolaridade, apoiando a utilização de dados normativos que considerem estas variáveis. Com esta abordagem, o Mini-Mental State Examination poderá ser um instrumento sensível e específico para o rastreio da doença de Alzheimer em todos os níveis de cuidados de saúde, mas a acuidade de diagnóstico é limitada noutras situações frequentes em consultas especializadas, como o défice cognitivo ligeiro

  7. [Relational and reproductive trajectories leading to adolescent pregnancy in Portugal: a national and regional characterization].

    PubMed

    Pires, Raquel; Pereira, Joana; Pedrosa, Anabela Araújo; Bombas, Teresa; Vilar, Duarte; Vicente, Lisa; Canavarro, Maria Cristina

    2014-01-01

    Introdução: Este estudo pretendeu caracterizar as trajetórias relacionais e reprodutivas conducentes à gravidez na adolescência em Portugal, explorando a existência de especificidades regionais.Material e Métodos: O estudo decorreu entre 2008 e 2013 em 42 serviços de saúde públicos. A amostra, nacionalmente representativa, incluiu 459 grávidas com idades entre os 12 e os 19 anos. Os dados foram obtidos por autorrelato, através de uma ficha de caracterização construída para o efeito.Resultados: Independentemente de terem tido um (59,91%) ou múltiplos parceiros sexuais (40,09%), as adolescentes engravidaram de forma mais frequente numa relação de namoro, utilizando contraceção à data da conceção e tendo identificado a falha contracetiva que esteve na origem da gravidez (39,22%). A nível regional, outras trajetórias surgiram com elevada prevalência, refletindo opções como a decisão de engravidar (Alentejo/Açores), a não utilização de contraceção (Centro/Madeira) ou a sua utilização ineficaz sem que a falha contracetiva fosse identificada (Madeira). As relações de namoro revelaram-se maioritariamente duradouras (> 19 meses), com homens mais velhos (> 4 anos) e fora do sistema de ensino (75,16%); estes resultados foram particularmente expressivos quando a gravidez foi planeada.Discussão: O conhecimento gerado por este estudo reflete a necessidade de investir em abordagens preventivas que atendam às necessidades específicas das jovens de cada região e integrem a população masculina de maior risco.Conclusão: Os nossos resultados podem contribuir para o delineamento de políticas de saúde mais eficazes e para uma atuação multidisciplinar mais informada ao nível da educação sexual e do planeamento familiar nas diferentes regiões do país.

  8. Quality Markers in Cardiology. Main Markers to Measure Quality of Results (Outcomes) and Quality Measures Related to Better Results in Clinical Practice (Performance Metrics). INCARDIO (Indicadores de Calidad en Unidades Asistenciales del Área del Corazón): A SEC/SECTCV Consensus Position Paper.

    PubMed

    López-Sendón, José; González-Juanatey, José Ramón; Pinto, Fausto; Cuenca Castillo, José; Badimón, Lina; Dalmau, Regina; González Torrecilla, Esteban; López-Mínguez, José Ramón; Maceira, Alicia M; Pascual-Figal, Domingo; Pomar Moya-Prats, José Luis; Sionis, Alessandro; Zamorano, José Luis

    2015-11-01

    Cardiology practice requires complex organization that impacts overall outcomes and may differ substantially among hospitals and communities. The aim of this consensus document is to define quality markers in cardiology, including markers to measure the quality of results (outcomes metrics) and quality measures related to better results in clinical practice (performance metrics). The document is mainly intended for the Spanish health care system and may serve as a basis for similar documents in other countries.

  9. Fast Uncooled Low Density FPA of VPD PbSe for Applications in Hyperspectral Imagery

    DTIC Science & Technology

    2009-10-01

    Marañosa (ITM-CIDA). Area de Optronica y Acustica Unidad de Sensores y Micro-Nano Tecnologia Arturo Soria, 289 E-28033 Madrid, Spain ABSTRACT...ADDRESS(ES) Instituto Tecnologico de la Marañosa (ITM-CIDA). Area de Optronica y Acustica Unidad de Sensores y Micro-Nano Tecnologia Arturo Soria, 289

  10. Conference Proceedings of International High Speed Networks for Scientific and Technical Information, Held at Ottawa, Canada on 6-7 October 1993 (Les Reseaux Internationaux Rapides D’Echange D’Information Scientifique et Technique)

    DTIC Science & Technology

    1994-02-01

    Unidad de In the information systems you can obtain the addresses Coordinaci6n de Bibliotecas (CBIC) of CSIC and the 0 of OPACs (Open Public Access... bibliotecas y unidades de informacion en ia empresa", Documentaci6n Cientifica, Jul-Sep 1992, ISSN 0210-0614. li-I TRAINING & OPERATIONS SUPPORT SYSTEM

  11. International Workshop on Membrane Biotechnology and Membrane Biomaterials (4th) Held in La Manga, Murcia, Spain on 29 May-2 June 1991.

    DTIC Science & Technology

    1991-06-02

    HERNANDEZ-BORRELL, Jordi; Unidad de Fisicoquimica , Departamento de Farmacia, Universidad de Barcelona, 08028 Barcelona, Spain KEOUGH, Kevin M. W.; Dept...Avda. Blasco Ibafiez 13, i 46010 VALENCIA, Spain LLOVET LOMBARTE, M. Isabel; Depto. Farmacia. Unidad de Fisicoquimica , Facultad de Farmacia, Avda

  12. [Early diagnostic accuracy of the O'Sullivan test in gestational diabetes].

    PubMed

    Rojas-Carrera, Sonia Irma; Márquez-Celedonio, Félix Guillermo; Lagunes-Mijangos, Adrián; González-Arriola, Víctor Manuel

    2013-01-01

    Objetivo: estimar la sensibilidad y la especificidad diagnóstica de la prueba de O'Sullivan para diabetes gestacional en el embarazo temprano. Metodología: se realizó estudio piloto que incluyó 50 mujeres con embarazo de bajo riesgo, sin alteración de glucosa. Se realizó la prueba de O'Sullivan para identificación de diabetes gestacional entre las semanas 14 y 23, y entre las semanas 24 y 28 para comparar resultados. Se administraron 50 g de glucosa, se cuantificó la glucemia a los 60 minutos y se consideró positiva si los valores eran = 140 mg/dL. Se calcularon sensibilidad, especificidad y valores predictivos. Resultados: la prueba de O'Sullivan entre las semanas 14 y 23 resultó positiva en tres de las gestantes (6 %), y la realizada entre las semanas 24 y 28 fue positiva en cuatro (8 %). No hubo diferencia estadística de la prueba entre ambas mediciones (p > 0.05). La sensibilidad fue de 75 % (IC 95 % de 30.1 % a 95.4 %), la especificidad de 100.0% (IC 95 % de 92.3 % a 100.0 %). Conclusiones: la prueba de O'Sullivan realizada entre las semanas 14 y 23 de gestación mostró buena sensibilidad y especificidad para identificar diabetes gestacional temprana.

  13. [Comparing the Application of Hema-Obs RSS to 250 Pregnancies from Obstetrics/Hematology Consultation in Centro Hospitalar São João, Portugal with the Application of Galit Sarig RSS to 90 Pregnancies from Rambam Health Care Campus, Israel].

    PubMed

    Salselas, Ana; Pestana, Inês; Bischoff, Francisco; Guimarães, Mariana; Andrade, Joaquim Aguiar

    2015-01-01

    Introdução: Na consulta de Hematologia-Obstetrícia do Centro Hospitalar São João EPE, as grávidas com trombofilias, episódios trombóticos anteriores e/ou história familiar de trombofilia são avaliadas e medicadas, recorrendo a uma escala de estratificação de risco (EER Hema-Obs).Objectivos: Pretende-se, com este trabalho, avaliar a eficácia desta escala de estratificação de risco, comparando-a com uma escala semelhante, desenvolvida e publicada por Sarig (escala de estratificação de risco Sarig).Material e Métodos: Procedeu-se às seguintes comparações: distribuição, por grupos de risco, obtida pela aplicação das duas escalas, em simultâneo, a 250 grávidas seguidas, na consulta do Centro Hospitalar São João EPE; sensibilidade e especificidade para cada uma das escalas (teste DeLong aplicado às curvas Receiver Operating Characteristic); desfechos nas gestações seguidas no Centro Hospitalar São João EPE e pelo grupo de Sarig no Rambam Health Care Campus (Israel).Resultados: A estratificação de risco nas 250 grávidas foi: a) com a escala de estratificação de risco Hema-Obs - Risco Materno (29%), Alto Risco Materno-Fetal (47%), Muito Alto Risco Materno-Fetal (24%); b) com a escala de estratificação de risco Sarig - Baixo (24%), Intermédio (53%), Alto (16%), Muito Alto (7%). Aplicando as curvas Receiver Operating Characteristic a ambas as escalas, resultam áreas calculadas de 58,8% para a escala de estratificação de risco Hema-Obs e de 38,7% para a escala de estratificação de risco de Sarig, correspondendo a uma diferença estatisticamente significativa (p = 0,0006 pelo teste de DeLong). Nas gestações acompanhadas no Centro Hospitalar São João EPE verificaram-se 91% de gestações bem-sucedidas e 9% de abortamentos; nas gestações acompanhadas por Sarig verificaram-se 82% de gestações bem-sucedidas e 18% de abortamentos.Conclusões: Conclui-se que a escala de estratificação de risco Hema-Obs constitui um suporte

  14. Las propiedades de las estrellas extrañas en el marco de una nueva ecuación de estado para la materia extraña

    NASA Astrophysics Data System (ADS)

    Lugones, G.; Benvenuto, O. G.

    Se estudian las propiedades generales de las estrellas constituídas por materia extraña (ME) en el marco de una nueva ecuación de estado (EOS) en la que consideramos la masa de los quarks como dependiente del número medio de bariones por unidad de volumen. Se asume esta dependencia de forma que los quarks sean livianos (pesados) a densidades altas (bajas). En esta aproximación, la EOS de la ME es similar a la predicha por el modelo de la Bolsa del MIT, pero es significativamente mas dura a bajas densidades. Esta propiedad modifica las propiedades de las estrellas extrañas en forma notable. Encontramos que, con esta nueva EOS, los objetos pueden ser más masivos que en el caso de la EOS de la bolsa del MIT y que, además, pueden presentar mayores redshifts gravitatorios en hasta un 10%. En el caso de las oscilaciones radiales de estos objetos, calculamos la relación período vs. redshift gravitacional y encontramos una expresión analítica simple para el caso de las oscilaciones de objetos de baja masa. Encontramos que, aún con hipótesis muy diferentes en cuanto a la ecuación de estado de la materia extraña, las propiedades generales de estos objetos no se ve afectada en forma fundamental, y, por lo tanto, no deberían ser muy diferentes de las aquí expuestas.

  15. Hansen Neuropathy: Still a Possible Diagnosis in the Investigation of a Peripheral Neuropathy.

    PubMed

    Veiga, Andreia; Costa, Alexandre; Taipa, Ricardo; Guimarães, António; Pires, Manuel Melo

    2015-01-01

    Introdução: A lepra continua a ser uma das causas mais frequentes de neuropatia periférica. Apesar de tida como erradicada em Portugal, ainda se documenta no estudo neuropatológico de doentes com clínica de neuropatia periférica sem diagnóstico etiológico definido.Material e Métodos: Revisão dos casos neuropatia por doença de Hansen diagnosticados na Unidade de Neuropatologia do Centro Hospitalar do Porto no período de 1978 e 2013 atendendo ao género, idade, manifestações clínicas e achados neuropatológicos.Resultados: Foram identificados 21 doentes com diagnóstico neuropatológico de neuropatia por doença de Hansen, com predomínio do sexo masculino. A idade média ao diagnóstico foi de 52 anos, sendo a sintomatologia sensitiva predominante. O intervalo entre sintomatologia e diagnóstico oscilou entre 1 a 38 anos. Na maioria foi identificada forma tuberculoide em biópsia de nervo e detetados bacilos em pele e nervo em 44% dos casos.Discussão: A mononeurite é a forma mais comum de apresentação de hanseníase, podendo cursar com outras manifestações clínicas incluindo lesões cutâneas. A infeção pelo M. leprae lesiona fibras mielinizadas e não mielinizadas, com substituição do tecido nervoso por colagénio resultando em fibrose. O diagnóstico da lepra é apenas conseguido por estudo neuropatológico das lesões cutâneas e/ou nervo periférico, adjuvado pela identificação do bacilo.Conclusão: A doença de Hansen continua a ser um problema de saúde pública em áreas tropicais e, apesar de rara, ainda descrita em países ocidentais, devendo ser considerada como uma hipótese de diagnóstico na investigação de neuropatia periférica.

  16. Short and Long-Term Efficacy of Laparoscopic Ovarian Diathermy in Women with Polycystic Ovary Syndrome.

    PubMed

    Luz, Rita; Barros, Joana; Aguiar, Ana; Rodrigues, Cátia; Soares, Ana Paula; Nunes, Joaquim; Sousa, Sandra; Calhaz-Jorge, Carlos

    2016-08-01

    Introdução: A síndrome dos ovários poliquísticos é a causa mais frequente de anovulação e o tratamento envolve uma abordagem faseada. A electrocoagulação laparoscópica dos ovários é aceite como segunda linha no tratamento das doentes que não respondem ao citrato de clomifeno. Os objectivos deste estudo foram determinar a eficácia desta técnica a curto e longo prazo e definir os factores preditivos de gravidez espontânea. Material e Métodos: Este estudo retrospectivo envolveu 76 mulheres submetidas a electrocoagulação dos ovários entre 2004 e 2013, num hospital universitário. Os desfechos principais foram a regularidade menstrual e gravidez. Os resultados a curto prazo registados durante a vigilância na unidade foram revistos e os desfechos a longo prazo foram avaliados através de entrevista telefónica realizada a todas as mulheres operadas há mais de três anos. Dados clínicos e bioquímicos foram analisados como factores preditivos de gravidez espontânea em doentes sem outros factores de infertilidade. Resultados: A regularidade do ciclo menstrual foi alcançada inicialmente em 53 (70%) mulheres e a longo prazo, 52% (12/53) tinham ciclos regulares. Em geral, 53 (70%) mulheres engravidaram e foram obtidas 77 gravidezes, 60% das quais foram espontâneas. O único factor de prognóstico associado a gravidez espontânea foi a duração da infertilidade inferior a três anos (p < 0,05). Discussão: A electrocoagulação dos ovários demonstrou taxas de gravidez comparáveis a outros tratamentos de indução da ovulação com a vantagem de ter efeitos benéficos duradouros na regularidade menstrual e fertilidade. Conclusão: A electrocoagulação dos ovários é uma opção de tratamento segura e eficaz na infertilidade anovulatória em mulheres com síndrome dos ovários poliquísticos.

  17. Uma Visão do Universo Segundo um Grupo de Alunos do Ensino Médio de São Paulo

    NASA Astrophysics Data System (ADS)

    Elias, D. S.; Araújo, M.; Amaral, L. H.; Voelzke, M. R.; Araújo, M.

    2005-08-01

    A astronomia, embora seja uma ciência popular, com inúmeras descobertas de interesse público, ainda é apresentada desconsiderando-se os aspectos históricos e científicos relacionados ao seu desenvolvimento, sendo geralmente veiculada nos meios de comunicação de maneira pouco esclarecedora e não raro com imprecisões. Neste trabalho analisou-se a concepção de um grupo de estudantes de Ensino Médio sobre conceitos de astronomia, visando identificar sua visão de mundo a respeito do Universo, envolvendo idéias sobre espaço e tempo. Para issso, foi aplicado um questionário em três escolas da grande São Paulo em um espaço amostral de 270 alunos. Constatou-se que, embora o ensino de astronomia esteja previsto nos PCNEM, os resultados obtidos na pesquisa mostram que há grande deficiência no conhecimento dos temas investigados. Nesse sentido, verificou-se que apenas 20% dos alunos eram capazes de relacionar a sucessão das semanas com as fases da lua, enquanto 28% associaram as estações do ano à inclinação do eixo de rotação da Terra. Por outro lado, somente 23% dos alunos tinham noções das distâncias entre os objetos celestes próximos da Terra e 56% conseguiram relacionar o Big Bang com a origem do Universo. Finalmente, constatou-se que 37% reconheciam o ano-luz como uma unidade de distância e 60% reconheciam o Sol como sendo uma estrela. Apesar de 60% dos alunos indicarem que a escola é a principal fonte para aquisição dos conhecimentos de astronomia, conclui-se que seus conceitos nessa área ainda são inadequados, havendo necessidade de ampliação e aprimoramento da abordagem desses conteúdos nos ambientes escolares.

  18. [SwapINN: analytic study about prescription swaps at pharmacies].

    PubMed

    Moutinho, Ana; Alexandra, Denise; Rodrigues, Renata

    2014-01-01

    Introdução: A prescrição obrigatória por DCI foi imposta em 2012, para redução de custos do SNS e motivou discussão entre as partes envolvidas. Estudámos, numa população real, a dinâmica prescrição-dispensa de medicamentos.Objetivos: Determinar a percentagem de prescrições substituídas; avaliar os fatores associados à substituição; identificar as respetivas justificações; quantificar os diferenciais dos custos para utente e Serviço Nacional de Saúde.Material e Métodos: Estudo analítico. Amostra de conveniência constituída pelos medicamentos prescritos de uma unidade de saúde, de 19 a 23 de Dezembro de 2011. Três dias depois, os utentes foram entrevistados telefonicamente. Software: Excel® e SPSS®. Testes: Qui-quadrado e Mann-Whitney; n.s. = 0,05.Resultados: Total de 255 prescrições. A maioria foi efetuada a mulheres (62%), idade média 52 anos, 4 anos de escolaridade (33%) e para situações agudas (53%). Foram substituídas 31% das prescrições, sem relação com idade, sexo ou escolaridade, nem com o médico prescritor ou farmácia. Os medicamentos prescritos para situações crónicas foram menos substituídos (p < 0,001), assim como as prescrições de marca (p < 0,001). Os anti-infeciosos e anti-alérgicos foram os grupos com mais substituições (p = 0,009). Os utentes não se aperceberam da substituição em 72% dos casos. Nos casos de substituição, o utente pagou, em média, mais 79% que o prescrito e o Serviço Nacional de Saúde 5%.Discussão/Conclusão: Verificou-se substituição de 31% das prescrições, com mais custos para utente e Serviço Nacional de Saúde. Consideramos possível viés de seleção, informação e registo. Sendo agora obrigatória a prescrição por DCI, sugerimos a análise regular, a nível nacional, com base nas aplicações informáticas em uso, da prescrição e respetiva dispensa.

  19. The master and the telescopes - the interplay between astronomy and optics in history (German Title: Der Meister und die Fernrohre - Das Wechselspiel zwischen Astronomie und Optik in der Geschichte)

    NASA Astrophysics Data System (ADS)

    Hamel, Jürgen; Keil, Inge

    The use of the telescope for astronomical observations since 1609 was one of the milestones in the celestial research. The contributions in this volume present new insights into the invention of the telescope and its relations to reading stones and spectacles, present investigations of special telescope types of early manufacturers, and analyze the telescopes of some historical observatories and the investigations carried out with them. Other contributions deal with the pictorial appearance of telescopes in baroque art, the connection of telescopes with photography, as well as the development of reflectors in the 20th century. The volume is dedicated to Rolf Riekher, an internationally established specialist ior the history of the telescope, on the occasion of his 85th birthday.

  20. [Discourses and practices concerning the social participation process in health education activities: community mobilization in the PCDEN/PE. Programa de Controle das Doenças Endêmicas do Nordeste/Pernambuco].

    PubMed

    Acioli, M D; de Carvalho, E F

    1998-01-01

    This study analyzes and compares several social participation concepts in health education processes to practical experiences with schistosomiasis prevention measures under the Northeast Endemic Disease Control Program (Brazilian Ministry of Health/World Bank, 1987). Using qualitative methods, institutional documents and discourses were interpreted (Sucam, FNS, and Ministry of Health). A field study was also performed (using interviews with community-based health agents and the general population) in the Zona da Mata region of Pernambuco (a historically endemic area for schistosomiasis), focused in the county of Amaraji. Comparing discourses and educational practices, we found factors that explain respective points of convergence and divergence, as well as elements linked to the social and historical process of the target population which systematically limit the efficacy of such educational measures.

  1. [Distribution of financial resources according to the productivity (determined by bibliometry) in the Medical Research Laboratories of the Hospital das Clínicas da Faculdade de Medicina da Universidad de São Paulo (Brazil)].

    PubMed

    Montes, G S

    2000-04-01

    A challenge that research managers have to face is how to "reallocate" agency budgets in order to bring them in line with the results of performance reviews. Research policies must develop a strategic plan describing their goals, devise yardsticks to measure their progress, and tie that performance to allocate research funds with some degree of priority. Though Brazil already has a substantial presence in world's science, scientific enterprise must be used to strengthen it. The first step should be to raise standards in Brazilian science by concentrating the resources on supporting excellence. A strategy to judge biomedical research productivity should include tactics to disclose whether the resulting publications have appeared in the field's most respected, peer-reviewed journals. A pilot project to road-test the above-discussed ideas on performance measurements was conducted at the Laboratories of Medical Research (Clinical Hospital, University of São Paulo School of Medicine). These Laboratories perform a vast proportion of biomedical research at the country's largest University. This article illustrates that confidence in fairness and consistency with which funds are now being allocated has helped to improve productivity, thus showing that this strategy is fruitful.

  2. Psychometric evaluation of the SF-36 (v.2) questionnaire in a probability sample of Brazilian households: results of the survey Pesquisa Dimensões Sociais das Desigualdades (PDSD), Brazil, 2008

    PubMed Central

    2011-01-01

    Background In Brazil, despite the growing use of SF-36 in different research environments, most of the psychometric evaluation of the translated questionnaire was from studies with samples of patients. The purpose of this paper is to examine if the Brazilian version of SF-36 satisfies scaling assumptions, reliability and validity required for valid interpretation of the SF-36 summated ratings scales in the general population. Methods 12,423 individuals and their spouses living in 8,048 households were selected from a stratified sample of all permanent households along the country to be interviewed using the Brazilian SF-36 (version 2). Psychometric tests were performed to evaluate the scaling assumptions based on IQOLA methodology. Results Data quality was satisfactory with questionnaire completion rate of 100%. The ordering of the item means within scales clustered as hypothesized. All item-scale correlations exceeded the suggested criteria for reliability with success rate of 100% and low floor and ceiling effects. All scales reached the criteria for group comparison and factor analysis identified two principal components that jointly accounted for 67.5% of the total variance. Role emotional and vitality were strongly correlated with physical and mental components, respectively, while social functioning was moderately correlated with both components. Role physical and mental health scales were, respectively, the most valid measures of the physical and mental health component. In the comparisons between groups that differed by the presence or absence of depression, subjects who reported having the disease had lower mean scores in all scales and mental health scale discriminated best between the two groups. Among those healthy and with one, two or three and more chronic illness, the average scores were inverted related to the number of diseases. Body pain, general health and vitality were the most discriminating scales between healthy and diseased groups. Higher scores were associated with individuals of male sex, age below 40 years old and high schooling. Conclusions The Brazilian version of SF-36 performed well and the findings suggested that it is a reliable and valid measure of health related quality of life among the general population as well as a promising measure for research on health inequalities in Brazil. PMID:21812986

  3. James Baldwin und das Rassenproblem in den USA. Unterrichtsprojekt zum Komplex "Texte und ihre gesellschaftliche Bedingtheit" (James Baldwin and the Race Problem in the USA. Teaching Project in the Series "Texts and their Social Context")

    ERIC Educational Resources Information Center

    Kerschgens, Edda

    1977-01-01

    Reports on an 18-hour teaching project with students at a teachers' college. Four Baldwin texts were used. Questions considered included whether Baldwin's treatment of the race problem reveals any changes or shifts of emphasis. Suggestions are made for adaptation to teaching in grades 11-13. (Text is in German.) (IFS/WGA)

  4. Freiluftschulen: Eine Historisch-Padagogische Randerscheinung als Reflex Sozial-Historischer Modernisierungsprozesse? Das Beispiel Belgiens (Open-Air Schools: A Marginal Appearance in Pedagogical History as a Reflection of Socio-Historical Processes of Modernization? The Example of Belgium).

    ERIC Educational Resources Information Center

    Depaepe, Marc; Simon, Frank

    2003-01-01

    Discusses the history of open-air schools using an evaluation of Belgian schools. Expounds on the complex relationship between educational space and the educational act, and between traditional and progressive education. Demonstrates that open-air schools provided the same education as traditional schools and were not a real alternative for…

  5. Das Licht am Ende des Tunnels: Motivationsstrukturen fur den Deutschunterricht Reflexionen uber ein altes und stets neues Problem (The Light at the End of the Tunnel: Structures for Motivating German Teaching. Reflections on an Old and Continually New Problem).

    ERIC Educational Resources Information Center

    Classen, Albrecht

    2001-01-01

    Argues that despite the decline in enrollments in German at elementary and secondary schools and colleges and universities, there is reason to hope that interest can be invigorated. Suggests that there are easy instructional methods and materials for developing a new motivation in learning the language. (Author/VWL)

  6. Lehrer in der Bundesrepublik Deutschland. Eine Kritische Analyse Statistischer Daten uber das Lehrpersonal an Allgemeinbildenden Schulen. (Education in the Federal Republic of Germany. A Statistical Study of Teachers in Schools of General Education.)

    ERIC Educational Resources Information Center

    Kohler, Helmut

    The purpose of this study was to analyze the available statistics concerning teachers in schools of general education in the Federal Republic of Germany. An analysis of the demographic structure of the pool of full-time teachers showed that in 1971 30 percent of the teachers were under age 30, and 50 percent were under age 35. It was expected that…

  7. Der Zitier-Index (Science-Citation-Index): Eine Datenbank fur das Ermitteln von neuen Ideen und Konzepten (The Science Citation Index: A Database for the Discovery of New Ideas and Concepts).

    ERIC Educational Resources Information Center

    Simon, Hans-Reiner; Thormann, K.-D.

    This report discusses the use of the Science Citation Index produced by the Institute for Scientific Information (ISI) as a given "expert system" in the experimental study of different search levels. The inquiry has two objectives: (1) to test whether a "traditional" information system will also produce the rudiments of a…

  8. Georg Philipp Harsdörffer, the first astronomical card game, and the Christian constellations (German Title: Georg Philipp Harsdörffer, das erste astronomische Kartenspiel und die christlichen Sternbilder)

    NASA Astrophysics Data System (ADS)

    Gaab, Hans

    The first astronomical card game was issued in Nuremberg in 1656. Its author was the lawyer, writer and literary theoretican Georg Philipp Harsdouml;rffer (1607-1658), who is primarily remembered as the inventor of the “Nuremberg funnel”. It is possible that a second card game was issued in the same year, but the sources are ambiguous. After some preliminaries on the history of card games, Harsdörffer's pack of cards is presented. In addition, general remarks about the history of sky maps are given.

  9. Patterns of Strengths and Weaknesses on the WISC-V, DAS-II, and KABC-II and Their Relationship to Students' Errors in Oral Language, Reading, Writing, Spelling, and Math

    ERIC Educational Resources Information Center

    Breaux, Kristina C.; Avitia, Maria; Koriakin, Taylor; Bray, Melissa A.; DeBiase, Emily; Courville, Troy; Pan, Xingyu; Witholt, Thomas; Grossman, Sandy

    2017-01-01

    This study investigated the relationship between specific cognitive patterns of strengths and weaknesses and the errors children make on oral language, reading, writing, spelling, and math subtests from the Kaufman Test of Educational Achievement-Third Edition (KTEA-3). Participants with scores from the KTEA-3 and either the Wechsler Intelligence…

  10. Kindern das Wort geben: Ein interkulturell-kreativer Arbeitsansatz, aufgezeigt an der Arbeit mit tibetischen Migrantenkindern. (Tell the Children: A Beginning for Intercultural-Creative Work, Focusing on the Children of Tibetan Families.)

    ERIC Educational Resources Information Center

    Rabkin, Gabriele

    2001-01-01

    Explains the pedagogical and psychological concepts behind the approach developed by UNESCO that encourages children to express themselves freely on the subject of international understanding and peace in writing and art. Describes a project in which these concepts were applied focusing on a minority dispersed over many parts of the world:…

  11. Das US-Fachinformationssystem ERIC und die Entwicklung eines Fachinformationssystems Bildung in der Bundesrepublik Deutschland (The American Subject Information System ERIC and the Development of an Information System on Education in the German Federal Republic).

    ERIC Educational Resources Information Center

    Nachrichten fur Dokumentation, 1982

    1982-01-01

    In order to further develop West German information services for education, it is suggested that the ERIC structural model--a coordinating central office and a network of clearinghouses--be developed as a continuation of the existing "Dokumentationsring Padagogik" (DOPAED) documentation service. (16 references) (EJS)

  12. A estabilidade dos PAHS em função da energia da radiação interestelar nas faixas UV e raios-X

    NASA Astrophysics Data System (ADS)

    Pinotti, R.; Costa, R. K.; Boechat-Roberty, H. M.; Lago, A.; Souza, G. B.

    2003-08-01

    A nebulosa CRL 618, uma proto-nebulosa planetária cuja nuvem molecular espessa envolve uma estrela B0, contém uma grande quantidade de C2H2 e CH4. Estas moléculas são consideradas os tijolos da criação de grandes moléculas carbonadas como os Hidrocarbonetos Policíclicos Aromáticos (PAHs). Esta nebulosa, por estar exposta a intensos campos de UV e Raios-X, é uma região de fotodissociação molecular que propicia a formação de novas moléculas, confirmada pela presença de C4H2 e C6H6 (Benzeno), que é a unidade básica dos PAHs. Atribui-se a esta família de moléculas orgânicas duas propriedades fundamentais, a resistência para sobreviver ao campo de radiação UV interestelar e a geração das bandas de emissão não identificadas (UIR) observadas no infravermelho. No entanto, alguns autores questionam a resistência dos PAHs ao campo de radiação UV interestelar. Empregando a técnica de Espectrometria de Massas por Tempo de Vôo, no modo de coincidência fotoelétron-fotoíon, estudamos a ionização e fragmentação das seguintes moléculas: Benzeno, Benzeno deuterado, Naftaleno, Antraceno e Fenantreno. Utilizamos uma fonte de Hélio monocromática em 21,21 eV (584,5 Å) e a radiação Síncroton do Laboratório Nacional de Luz Síncroton (LNLS) em diferentes energias nas proximidades da borda do C 1s ( 290 eV). Comprovamos a estabilidade dos PAHs sob ação de UV (21,21 eV), onde eles apresentam um baixo nível de fotodissociação, produzindo fragmentos ionizados com rendimento total na ordem de 5 por cento em relação ao íon molecular pai. Entretanto, em altas energias, na faixa de Raios-X, a quebra destas moléculas torna-se mais intensa, com a produção de muitos fragmentos. Como uma das rotas de fragmentação do Naftaleno é [(C10H8) = > (C6H6+) + (C4H2) + (e-)], e como temos as evidências observacionais da existência do C4H2 e C6H6 na nebulosa CRL 618, sugerimos que este ambiente também possui o Naftaleno.

  13. [End of life in neonatology: palliative care integration].

    PubMed

    Soares, Célia; Rodrigues, Manuela; Rocha, Gustavo; Martins, Angelina; Guimarães, Hercília

    2013-01-01

    Introdução: A limitação terapêutica e a implementação dos cuidados paliativos em Neonatologia revestem-se de extrema relevância na atualidade e são já uma realidade com tendência crescente em vários países. Não obstante, em Portugal, os estudos, recomendações e protocolos oficiais no que diz respeito às questões em fim de vida são ainda escassos.Material e Métodos: Analisamos retrospetivamente os processos clínicos dos recém-nascidos falecidos na Unidade de Cuidados Intensivos do Centro Hospitalar de São João no período de 2010 a 2012 e comparamos os resultados com os obtidos num estudo realizado na mesma Unidade correspondente aos períodos 1992-1995 e 2002-2005.Resultados: Na população estudada as anomalias congénitas foram a causa de morte em 57,1% casos, a prematuridade extrema em 18,4% casos e a infeção em 16,3%. No que refere ao ‘modo de morrer’, a paragem cardiorrespiratória irreversível às manobras de reanimação observou-se em 57,1% casos; 20,4% faleceram após abstenção de tratamento e 22,4% após suspensão de tratamento. Verificaram-se diferenças significativas para o ‘modo de morrer’ e as variáveis tempo de internamento e presença dos pais no momento da morte. Em 28,6% casos houve registo de tomada de decisão pela limitação terapêutica e adoção de cuidados paliativos e em 16,3% decisão de não reanimar. Para as duas últimas registou-se um aumento ao longo das três décadas analisadas. Também se registou uma tendência crescente para a utilização de escala de avaliação de dor neonatal, opióides e sedativos, presença parental no momento da morte, reuniões entre pais e neonatologistas, reuniões interdisciplinares e apoio psicológico aos pais.Conclusão: Este estudo revela uma tendência crescente para a integração de medidas de limitação terapêutica e de cuidados paliativos na UCIN estudada. Contudo, há ainda muito a desenvolver, nomeadamente no que refere à investigação, forma

  14. PRESENT; PREScription of Enteral Nutrition in pediaTric Crohn's disease in Spain.

    PubMed

    Navas-López, Victor Manuel; Martín-de-Carpi, Javier; Segarra, Oscar; García-Burriel, José Ignacio; Díaz-Martín, Juan José; Rodríguez, Alejandro; Medina, Enrique; Juste, Mercedes

    2014-03-01

    Objetivos: La nutrición enteral exclusiva (NEE) es una de las estrategias terapéuticas empleadas para inducir la remisión en niños con enfermedad de Crohn (EC). Pese a que la NEE se recomienda en las guías de práctica clínica y en los documentos de consenso, la frecuencia real de su empleo en España es desconocida. Métodos: Encuesta compuesta por 70-items (PRESENT: PREScription of Enteral Nutrition in pediaTric Crohn’s disease in Spain) que se distribuyó a través de la lista de distribución de Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica (SEGHNP). Resultados: Se recibieron los datos de 51 unidades de Gastroenterología Pediátrica del territorio español. De los 287 pacientes recién diagnosticados de EC durante los años 2011-12 en esos centros (139 en 2011 y 148 en 20212), 182 (63%) recibieron NEE (58% en 2011 y 68% en 2012). El 26% de los pacientes que recibieron NEE estaban en recaída. Todos los facultativos que respondieron pensaban que la NEE es efectiva para inducir la remisión clínica en los brotes leves-moderados. El 24,5% no emplean la NEE durante las recaídas. Las formulas enterales empleadas más frecuentemente fueron las específicas para EC (70,6%), la vía oral fue la más utilizada, el 60,8% utilizaron saborizantes y el 9,8% de las unidades permitían un porcentaje variable de calorías en forma de otros alimentos durante el periodo de NEE. El 65% emplearon 5-ASA junto con la NEE, el 69% antibióticos y hasta un 95% inmunomoduladores. La duración de la NEE fue de 8 semanas en el 47,1% de los casos, la transición hacia una dieta normal se realizó de forma secuencial. En relación a las barreras y factores limitantes encontrados por los respondedores para instaurar la NEE destacaban la falta de aceptación por el paciente y/o la familia (71%), falta de tiempo o de personal auxiliar (69%) y la dificultad para convencer al paciente o su familia de la idoneidad del tratamiento (43%). Conclusiones

  15. Invasive Meningococcal Disease: Application of Base Excess and Platelets Score in a Portuguese Paediatric Intensive Care Unit.

    PubMed

    Martins, Luis; Mação, Patrícia; Pinto, Carla; Dionísio, Teresa; Dias, Andrea; Dinis, Alexandra; Carvalho, Leonor; Neves, José Farela

    2015-01-01

    Introdução: A infeção meningocócica tem uma elevada mortalidade e morbilidade. Recentemente foi desenvolvido um score de prognóstico para a doença meningocócica invasiva em idade pediátrica, baseado na contagem plaquetar e no excesso de base - o Base Excess and Platelets Score. O objetivo principal desde estudo foi avaliar a precisão prognóstica do Base Excess and Platelets Score em doentes admitidos em cuidados intensivos pediátricos por doença meningocócica invasiva.Material e Métodos: Estudo observacional, com colheita de dados retrospetiva, que incluiu um período de 13,5 anos (01/2000 a 06/2013). Foram analisados: mortalidade por doença meningocócica invasiva e fatores associados (disfunção de órgão e falência multi-órgão). Foi calculado o Base Excess and Platelets Score de forma retrospetiva, para avaliar a sua precisão na predição da mortalidade e foi comparado com o Paediatric Risk of Mortality e Paediatric Index of Mortality2.Resultados: Foram admitidas 76 crianças com doença meningocócica invasiva. O tipo de disfunção mais frequente foi a cardiovascular (92%), seguida da hematológica (55%). Cumpriram critérios de falência multi-órgão 47 doentes (62%). A mortalidade global foi de 16%. A disfunção neurológica e a renal foram as que apresentaram uma maior associação com a mortalidade, odds ratio ajustado 315 (26 - 3 804) e 155 (20 - 1 299). Após aplicação das curvas receiver operating characteristic, o Base Excess and Platelets Score tinha umaarea under curve de 0,81, o Paediatric Index of Mortality2 de 0,91 e o Paediatric Risk of Mortality de 0,96.Discussão: O Base Excess and Platelets Score apresentou uma boa precisão apesar de não tão elevada como o Paediatric Index of Mortality2 ou o Paediatric Risk of Mortality.Conclusões: O Base Excess and Platelets Score pode ser útil como indicador prognóstico na doença meningocócica invasiva, por apresentar uma elevada sensibilidade e especificidade e ser

  16. Una Red de Expertos en Salud Ambiental de Niños (2015)

    EPA Pesticide Factsheets

    Unidades Pediátricas de Especialidad en Salud Ambiental (PEHSU) tiene expertos en pediatria, alergias e inmunologia, desarrollo neural, toxicologia, y otras, ya que existen varios factores que afectan la salud de los ninos.

  17. Chinese Economic Coercion Against Taiwan: A Tricky Weapon to Use

    DTIC Science & Technology

    2007-01-01

    UNISCI discussion papers, Madrid: Unidad de Investigación sobre Seguridad y Cooperación Internacional, January 2004. 3 The National People’s Congress is...disruption as a result of such Internet attacks. Since 2000, mainland hackers have attempted numerous cyberattacks designed to harass, disrupt, or...papers, Madrid: Unidad de Investigación sobre Seguridad y Cooperación Internacional, January 2004. Online at http://www.ucm.es/info/unisci/TUNG4M.pdf

  18. [Validation of the ice pack test in ophthalmoparesis due to myasthenia gravis].

    PubMed

    Ramirez-Antunez, Ángel G; García-Ramos, Guillermo; Estañol-Vidal, Bruno; Juárez-Flores, Alejandra

    2013-11-01

    Introduccion. La miastenia grave es una enfermedad autoinmune de la union neuromuscular que se presenta clinicamente como debilidad fluctuante de los musculos estriados, como los de la region ocular (miastenia ocular). Objetivo. Demostrar que la sensibilidad y la especificidad de la prueba de hielo son altas en el diagnostico diferencial de la oftalmoparesia y ptosis palpebral por miastenia grave y miastenia ocular. Sujetos y metodos. Estudio observacional, analitico, no aleatorizado, de una muestra de 43 sujetos, 21 con miastenia grave y 22 controles. A todos los pacientes se les aplico un guante con hielo sobre sus parpados superiores afectados durante dos minutos, despues de los cuales se evaluo el grado de mejoria de la ptosis palpebral y la oftalmoparesia. Todos tenian estudio de estimulacion nerviosa repetitiva. Resultados. Se analizaron 36 pacientes, 18 con miastenia grave u ocular y 18 controles. Todos presentaron ptosis palpebral y solo 20 de ellos oftalmoparesia. La prueba de hielo para la oftalmoparesia mostro una sensibilidad del 83%, especificidad del 100%, valor predictivo positivo (VPP) del 100% y valor predictivo negativo (VPN) del 80% en el diagnostico de la miastenia grave. Para la ptosis palpebral, se determino una sensibilidad del 89%, especificidad del 100%, VPP del 100% y VPN del 90%. Para la estimulacion nerviosa repetitiva se calculo una sensibilidad del 61%, especificidad del 83%, VPP del 79% y VPN del 68%. Conclusion. La prueba de hielo es sencilla, segura, economica, rapida y fiable para utilizarse de rutina en pacientes con sospecha de ptosis u oftalmoparesia por miastenia grave, ya que tiene una alta validez, seguridad y reproducibilidad como prueba diagnostica.

  19. PubMed

    Jiménez-Talamantes, Raquel; Rizk Hernández, Jennifer; Quiles Izquierdo, Joan

    2017-02-01

    Introducción:la evaluación de la obesidad en las encuestas de salud contempla el estudio de las características corporales por medición o por declaración. Según el método utilizado puede producirse una estimación diferente de la frecuencia de este problema.Objetivos: medir las discrepancias en las estimaciones de prevalencia de obesidad y exceso de peso realizadas con datos declarados con respecto a los medidos en una encuesta poblacional.Métodos: estudio transversal de una muestra de 1.153 sujetos adultos donde se compararon los datos de peso y talla declarados y medidos mediante la correlación de Pearson (r). Se calcularon las prevalencias de obesidad y exceso de peso según ambos métodos y se obtuvo el índice kappa, la sensibilidad y la especificidad para estimar la capacidad predictiva de los datos declarados.Resultados: los valores de peso, talla e IMC declarados y medidos presentaron una correlación de 0,96, 0,93 y 0,91, respectivamente. La prevalencia de obesidad declarada fue 16,4% y la medida 23,3% (kappa = 0,68), sensibilidad 63,2% y especificidad 97,9%. La prevalencia de exceso de peso declarada fue 51,4% y por medición 61,1% (kappa = 0,73), sensibilidad 81,3% y especificidad 95,3%. Las diferencias observadas fueron estadísticamente significativas.Conclusiones: existe una subestimación de las prevalencias de obesidad y de exceso de peso en poblaciones cuando se usan datos antropométricos declarados, pero una buena concordancia y especificidad con las estimaciones realizadas con datos medidos.

  20. [Association of Doppler flowmetry with perinatal outcome in patients with oligohydramnios].

    PubMed

    Romero-Gutiérrez, Gustavo; Herrera-Coria, José; Ruiz-Treviño, Armando Saúl

    2014-01-01

    Introducción: el oligohidramnios en ocasiones se asocia a mala evolución perinatal. El objetivo fue determinar la asociación de la flujometría Doppler con la evolución perinatal en pacientes con oligohidramnios. Métodos: se realizó un estudio transversal en el que se analizaron 130 pacientes con embarazo de 30 a 41 semanas con oligohidramnios; se comparó la medición del índice de resistencia de la arteria umbilical por flujometría Doppler y la medición del líquido amniótico. Se hizo un seguimiento postnatal en el que se registró el Apgar y si los pacientes ameritaron cuidados especiales. Se utilizó estadística descriptiva y se calculó la sensibilidad, especificidad, exactitud y los valores predictivos de las pruebas. Resultados: para el oligohidramnios en muerte perinatal se obtuvo sensibilidad, especificidad y exactitud de 100, 0 y 50 %; y para Apgar de 0, 0 y 0 %, respectivamente. El índice de resistencia de la arteria umbilical referente a la muerte perinatal tuvo sensibilidad, especificidad y exactitud de 100, 96 y 98 %, en tanto que en el Apgar los valores fueron de 0, 95 y 47.5 %, respectivamente. Conclusiones: la flujometría Doppler de la arteria umbilical mostró mayor sensibilidad, especificidad y exactitud que la medición del oligohidramnios y la prueba de Apgar para diagnosticar muerte perinatal.

  1. [Atrophy in the mucosa neighboring an intestinal-type gastric adenocarcinoma by comparing the Sydney vs. OLGA systems].

    PubMed

    Ramírez-Mendoza, Pablo; Hernández-Briseño, Liliana; Casarrubias-Ramírez, Moisés; Alvarado-Cabrero, Isabel; Ángeles-Garay, Ulises

    2015-01-01

    Introducción: el carcinoma gástrico ocasiona al año unas 700 000 muertes en el mundo. El objetivo de este artículo es evaluar la atrofia en la mucosa vecina al adenocarcinoma gástrico tipo intestinal comparando los sistemas Sídney y OLGA. Diferencias en el rendimiento diagnóstico impulsarían el empleo de alguno. Métodos: estudiamos 28 sujetos con adenocarcinoma gástrico tipo intestinal (Lauren), que comparamos con 32 casos sin neoplasia, ambos grupos con gastrectomía total. Dos patólogos evaluaron la atrofia en el epitelio de cuerpo y antro no neoplásico con los sistemas Sídney y OLGA. Se obtuvieron la media, mediana y distribución de frecuencias por escala de medición, así como la distribución de las variables del estudio. Se calculó la sensibilidad, especificidad y los valores predictivos para cáncer gástrico gracias a dicotomizar las escalas con resultado positivo y negativo para atrofia avanzada. Resultados: veinticuatro de 28 casos con adenocarcinoma gástrico tipo intestinal mostraron atrofia avanzada con OLGA con una sensibilidad y especificidad de 77 y 85 % respectivamente. Con el sistema Sídney, 4 de 28 mostraron atrofia avanzada con una sensibilidad y especificidad de 14 y 100 % respectivamente. Conclusiones: el sistema OLGA tiene elevada sensibilidad y especificidad (77 y 85 % respectivamente) para reconocer cambios preneoplásicos en la mucosa vecina al cáncer gástrico. Empero, OLGA no mostró atrofia avanzada en adenomas foveolares con displasia de alto grado, ni en adenocarcinomas en las porciones proximales del estómago.

  2. [What is hidden behind the Baking Tray Task? Study of sensibility and specificity in right-hemispheric stroke patients].

    PubMed

    Garcia-Fernandez, Juan; Garcia-Molina, Alberto; Aparicio-Lopez, Celeste; Sanchez-Carrion, Rocío; Ensenat, Antònia; Pena-Casanova, Jordi; Roig-Rovira, Teresa

    2015-12-16

    Introduccion. Tham y Tegner propusieron el Baking Tray Task (BTT) como una prueba de evaluacion rapida y simple para la deteccion de negligencia espacial. No obstante, apenas existen estudios que hayan examinado su validez como prueba diagnostica. Objetivo. Analizar la validez diagnostica del BTT, midiendo su especificidad y sensibilidad, en una muestra de sujetos con ictus hemisfericos derechos. Sujetos y metodos. Cuarenta y ocho pacientes con lesiones vasculares hemisfericas derechas distribuidos en dos grupos (grupo negligencia, n = 35; grupo no negligencia, n = 13) en funcion de las puntuaciones obtenidas en una bateria de exploracion visuoespacial. La ejecucion de los participantes en el BTT se comparo con un grupo control sano (n = 12). Resultados. Los resultados mostraron una alta sensibilidad del BTT, pero una baja especificidad. Ocho de los 13 integrantes del grupo no negligencia obtuvieron un rendimiento en el BTT sugestivo de negligencia. Conclusiones. El BTT se muestra como un test sensible para la deteccion de la negligencia espacial. Sin embargo, basandonos en su baja especificidad, no es recomendable su uso aislado como prueba unica de diagnostico.

  3. A Neurologist's Hard Day's Work: Impact of Inpatient Neurology Consultation in a Tertiary Hospital.

    PubMed

    Rocha, Helena; Monteiro, Ana; Gomes, Tiago; Grilo, Miguel; Carvalho, Marta

    2016-01-01

    Introdução: A consulta de neurologia realizada a doentes hospitalizados sob a responsabilidade de outras especialidades é um trabalho exigente mas muitas vezes sub-valorizado e pouco documentado. Este estudo pretendeu avaliar o impacto das consultas internas de neurologia num hospital português e, consequentemente, a performance do nosso Serviço no que diz respeito a esta matéria. Material e Métodos: Foi conduzido um estudo retrospetivo durante o ano de 2013 através da revisão de dados clínicos e demográficos. Resultados: Ao longo de um ano, os neurologistas no nosso Serviço avaliaram 632 doentes internados. As principais razões para o pedido de consulta foram a alteração do estado mental/comportamental, défice neurológico focal e crises epiléticas. Os pedidos de avaliação provieram principalmente de serviços médicos mas também de Unidades de Cuidados Intensivos e Intermédios. Os neurologistas sugeriram investigação adicional em cerca de 50% dos doentes; alterações terapêuticas foram efetuadas numa proporção semelhante de doentes. No final da consulta foi possível estabelecer um novo diagnóstico em 63% dos casos, sendo os mais frequentes manifestação neurológica de doenças sistémicas, epilepsia e doença vascular cerebral. Tal intervenção teve impacto no cuidado de 68% dos doentes. Discussão e Conclusão: Diferentes estudos na literatura suportam os nossos achados, enfatizando que esta atividade tem benefícios diretos no tratamento dos doentes e que é custo-efetiva. Os nossos resultados sugerem que a atividade de consultadoria interna da Neurologia resulta em intervenções úteis para a gestão clínica dos doentes internados.

  4. ANÁLISE DA INSERÇÃO DOS TEMAS DE HUMANIDADES E ÉTICA, COM METODOLOGIA DE APRENDIZAGEM BASEADA EM PROBLEMAS, EM CURRICULO MÉDICO INTEGRADO EM ESCOLA PÚBLICA NO DISTRITO FEDERAL, BRASIL

    PubMed Central

    Novaes, Maria Rita Carvalho Garbi; Novaes, Luiz Carlos Garcez; Guilhem, Dirce; Lolas, Fernando; Silveira, Carla; Guiotti, Murilo

    2009-01-01

    Objetivo Realizar uma análise da inserção da ética e humanidades no currículo do Curso de Medicina da Escola Superior em Ciências da Saúde - ESCS, escola pública do Distrito Federal, Brasil, de forma a contribuir com o processo de gestão curricular. Metodologia O Estudo é de coorte e documental. Foram pesquisados 37 termos relacionados à ética e 36 referentes à humanização nos objetivos educacionais e conteúdo dos módulos temáticos, habilidades e atitudes e interação ensino-serviço-comunidade, de 1a a 4a série e no programa do internato no currículo (ano 2006) e no projeto pedagógico do Curso de Medicina (2001). Resultados Maior inserção da humanização, ética e bioética na 1a e 2a série, quando comparado à inserção na 3a e 4a série e no internato, (IC95%-α=0,034, pvalue=0,007). Unidade de habilidades e atitudes: freqüência das 3 temáticas no currículo da 1a a 4a séries (IC95%-α=0,026, pvalue=0,013). Quando comparada a inserção entre o internato e as quatro primeiras séries, observa-se que nestas a inserção da temática humanização é superior (IC95%-α=0,042, pvalue=0,029). Conclusão O currículo desenvolvido no ano de 2006 na ESCS apresentou correlação com o projeto pedagógico do curso e contemplou a temática de forma abrangente, em todas as séries e internato. PMID:20396594

  5. Diet choice in weight-restored patients with eating disorders; progressive autonomy process by nutritional education.

    PubMed

    Ruiz-Prieto, Inmaculada; Bolaños-Ríos, Patricia; Jáuregui-Lobera, Ignacio

    2013-01-01

    Introducción: El comportamiento alimentario humano está regulado por numerosos factores. Mientras los pacientes con anorexia nerviosa muestran un patrón nutricional restrictivo, los pacientes con bulimia nerviosa presentan episodios de atracón y purgas. Aunque los tratamientos son muy efectivos en la normalización de la composición corporal los comportamientos alimentarios inadecuados tienden a mantenerse constituyendo un factor de riesgo de recaídas y recidivas. Objetivos: El objetivo de este trabajo fue evaluar la calidad de la elección nutricional de pacientes con trastornos de la conducta alimentaria durante un programa de un año de educación nutricional analizando la mejoría en la capacidad de elección. Método: Treinta y un pacientes de una unidad de trastornos alimentarios planificaron un menú tras la normalización de la composición corporal, tarea que repitieron cada tres meses durante el año de intervención. Resultados: Los pacientes mejoraron el tiempo emplea - do en configurar el menú (p < 0,01), el Índice de Masa Corporal (p < 0,01), la masa grasa corporal (p < 0,01), la energía (p < 0,05), los carbohidratos (p < 0,01) y los ácidos grasos poliinsaturados (p < 0,05) de los menús planificados. No hubo diferencias en cuanto al total de grasas, perfil lipídico, vitaminas y minerales. El 12,9% y 3,2% de los pacientes escogieron sus menús de acuerdo a las recomendaciones de perfil calórico y lipídico, respectivamente, tras el año de tratamiento. Discusión: Aunque los pacientes mejoraron el contenido energético y los carbohidratos en los menús elegidos, tendieron a reducir el contenido calórico y las grasas en su elección, lo que puede conducir a una peor evolución. Conclusiones: Durante un año de educación nutricional, junto con el correspondiente tratamiento psicológico y psiquiátrico, se observó una mejoría en los factores dietéticos habitualmente implicados en una posible mala evolución.

  6. Late stillbirth: a ten year cohort study.

    PubMed

    Robalo, Raquel; Pedroso, Célia; Amaral, Njila; Soares, Clara

    2013-01-01

    Introdução: A morte fetal tardia é um acontecimento que se mantém na prática diária, apesar de protocolos de vigilância pré-natal e intraparto. Objectivo: Análise dos factores que contribuíram para a causa principal ou condições associadas a morte fetal tardia num período de 10 anos Métodos: Coorte retrospectiva de 208 gestações tardias simples, cujo parto em unidade terciária de cuidados perinatais resultou no nascimento de um nado morto, num período de dez anos. Através de consulta de processo clínico foram analisados dados clínicos, laboratoriais e resultados de estudo anatomo-patológico feto-placentário. Resultados: A incidência de morte fetal tardia foi de 3,5 por cada 1000 nascimentos. Não foram encontradas quaisquer tendências na incidência de MF tardia ao longo do tempo de estudo. Em 12 (5,8%) casos a morte fetal foi um acontecimento intraparto e 72 (35%) eram gestações de termo. Em 14% a gravidez não foi vigiada. A IG média de diagnóstico foi 34 semanas. A principal causa de morte associou-se a patologia fetal, tendo sido identificados factores fetais em 59 casos, destes 25% foram considerados leves para a idade gestacional. Em 24.5% dos casos a causa de morte foi inexplicada. Identificaram-se factores de risco materno em 21% dos casos, a patologia hipertensiva foi frequente e foi associada a idade gestacional precoce (p = 0,028). Conclusões: Não houve oscilações na incidência de morte fetal tardia ao longo dos dez anos avaliados. A incidência foi de 3,5‰, idêntica à descrita em países desenvolvidos. Cerca de um quarto das mortes fetais foram inexplicadas. A patologia materna mais frequente foi a hipertensão crónica.

  7. Detecção da fase impulsiva de uma explosão solar gigante até 405 GHz

    NASA Astrophysics Data System (ADS)

    Raulin, J.-P.; Makhmutov, V.; Kaufmann, P.; Pacini, A. A.; Luethi, T.; Hudson, H. S.; Gary, D. E.; Yoshimori, M.

    2003-08-01

    A explosão ocorrida no dia 25/08/2001 foi uma das mais intensas do presente ciclo solar em ondas de rádio de altas frequências. Foram medidas em ondas milimétricas e submilimétricas, aproximadamente, 105 e vários milhares de unidades de fluxo solar, respectivamente. Apresentamos um estudo deste evento em múltiplas frequências, desde microondas (1GHz), até ondas submilimétricas (405 GHz) detectadas pelo Telescópio Solar para ondas Submilimétricas (SST). Esta base de dados foi complementada utilizando-se o experimento Yohkoh, incluindo a emissão em raios-X duros e raios-g (até 100 MeV), e imagens em raios-X moles da região ativa envolvida. Enfocamos e discutimos principalmente os seguintes aspectos da fase impulsiva do evento: (i) as implicações deduzidas do espectro eletromagnético, obtido pela primeira vez até 405 GHz; (ii) a dinâmica da região ativa. Os resultados mostram que para explicar o espectro rádio observado, são necessários entre 3.5×1037 e 1.5×1039 elétrons acelerados acima de 20 keV em uma região de campo magnético entre 300 e 800 Gauss. A estimativa do fluxo de fótons que seria produzido por estes elétrons, mostra que grande parte deles não precipitou na baixa atmosfera. A evolução temporal da emissão em raios-X moles revela que a configuração magnética da região ativa foi muito dinâmica durante a fase impulsiva da explosão. Em particular, mostramos que a produção dos elétrons altamente energéticos foi iniciada junto com a aparição, na baixa coroa solar, de um novo sistema compacto de estruturas magnéticas. Este fato sugere que os locais de aceleração estão localizados na baixa atmosfera do Sol, como resultado da interação entre o novo sistema compacto e o campo magnético ambiente da região ativa.

  8. Quality of Recovery after Anesthesia: Validation of the Portuguese Version of the 'Quality of Recovery 15' Questionnaire.

    PubMed

    Sá, Ana Carolina; Sousa, Gabriela; Santos, Alice; Santos, Cristina; Abelha, Fernando José

    2015-01-01

    Introdução: O questionário "Quality of Recovery 15" tem sido utilizado para o estudo da qualidade de recuperação após anestesia. O objetivo deste estudo foi validar a versão Portuguesa do questionário "Quality of Recovery 15". Material e Métodos: Após aprovação pela Comissão de ética institucional, foi realizado um estudo de coorte prospectivo em doentes submetidos a cirurgia eletiva de junho a agosto de 2013. A versão portuguesa do "Quality of Recovery 15" foi aplicada antes da cirurgia (T0) e 24 h após a cirurgia (T1) em 170 doentes. Os doentes incapazes de dar consentimento informado ou com comprometimento cognitivo foram excluídos. Má qualidade de recuperação foi definida para pontuações de "Quality of Recovery 15" em T1 inferiores à média das pontuações de "Quality of Recovery 15" menos 1 desvio padrão. Confiabilidade e discordãncia entre observadores foram avaliadas por meio da correlação intraclasse. Testes não-paramétricos foram utilizados para comparações. Resultados: Observou-se uma correlação negativa entre pontuações de "Quality of Recovery 15" e tempo de internamento na Unidade Pós-Anestésica (p = -0,264, p = 0,004) e tempo de internamento hospitalar (p = -0,274, p = 0,004). Trinta e dois doentes (19%) tiveram má qualidade de recuperação. Os doentes com má qualidade de recuperação tinham mais frequentemente diabetes mellitus e hipertensão arterial e estavam medicados com antidepressivos com mais frequência. Os doentes com má qualidade de recuperação foram mais frequentemente submetidos a anestesia combinada e menos frequente a anestesia geral e locorregional (p = 0,008). O questionário teve boa consistência interna; a confiabilidade do teste-reteste foi boa. Discussão: A versão portuguesa do "Quality of Recovery 15" mostrou boa correlação com a versão original. Conclusão: Este questionário parece ser uma avaliação precisa e confiável para a qualidade de recuperação.

  9. [FATA Study: prevalence of atrial fibrillation and antithrombotic therapy in primary health care in a northern city of Portugal].

    PubMed

    Gomes, Eva; Campos, Rui; Morais, Renata; Fernandes, Marta

    2015-01-01

    Introdução: A fibrilhação auricular é a arritmia sustentada mais prevalente. Está provada a eficácia da anticoagulação oral na prevenção do acidente vascular cerebral nestes doentes. Contudo, este parece ser um tratamento subutilizado. Objectivos: determinar a prevalência de fibrilhação auricular conhecida numa população dos Cuidados de Saúde Primários; identificar as principais comorbilidades, a terapêutica antitrombótica em curso e avaliar a sua adequação segundo as recomendações da European Society of Cardiology. Material e Métodos: Estudo observacional transversal analítico. População: todos os utentes com idade igual ou superior a 30 anos, inscritos em oito Unidades de Saúde Familiar de Vila Nova de Gaia, com diagnóstico de fibrilhação auricular. Resultados: A prevalência de fibrilhação auricular foi de 1,29% (n = 940), sendo superior no género masculino (p = 0,01) e aumentando com a idade (p < 0,001). As comorbilidades mais frequentes foram a hipertensão arterial (76,4%), a insuficiência cardíaca (32,0%) e a diabetes mellitus (28,2%). Um total de 52% realizava terapêutica anticoagulante, 29% antiagregantes plaquetários e 4% ambas as terapêuticas. Dos utentes com baixo risco trombótico, 63,6% estava a fazer erradamente algum tipo de terapêutica antitrombótica; dos utentes com elevado risco ou doença valvular 56,8% estava adequadamente sob terapêutica anticoagulante. Conclusão: A prevalência de fibrilhação auricular bem como a frequência das principais comorbilidades estão de acordo com a maioria dos estudos. Apesar de a maioria dos doentes se encontrar sob anticoagulação oral, apenas 56,8% dos utentes com fibrilhação auricular fazia terapêutica antitrombótica adequada segundo as recomendações da European Society of Cardiology, verificando-se uma subutilização acentuada deste tratamento.

  10. 78 FR 25591 - Magnuson-Stevens Act Provisions; Fisheries of the Northeastern United States; Northeast...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-02

    ... limits on allocated stocks; the Georges Bank (GB) Seasonal Closure Area; NE multispecies days-at-sea (DAS... restrictions designed to minimize habitat impacts, and reporting requirements (excluding DAS reporting... multispecies/monkfish DAS; (5) limits on the number of hooks that may be fished; (6) DAS Leasing Program...

  11. Bundle Approach to Reduce Bloodstream Infections in Neutropenic Hematologic Patients with a Long-Term Central Venous Catheter.

    PubMed

    Martinez, Jose Manuel; Leite, Luís; França, Daniela; Capela, Rita; Viterbo, Luísa; Varajão, Natalina; Martins, Ângelo; Oliveira, Isabel; Domingues, Nélson; Moreira, Ilídia; Santo, Ana; Trigo, Filipe; Mariz, Jose

    2015-01-01

    Introdução: O objetivo deste estudo foi reduzir através de um pacote de medidas as infeções sistémicas e as taxas de infeções com origem no cateter venoso central nos doentes hematológicos em neutropenia com cateter venoso central de longa duração. Material e Métodos: Estudo prospetivo não randomizado realizado na unidade onco-hematológica do Instituto Português de Oncologia do Porto no período compreendido entre 1 de agosto de 2010 até 31 de janeiro de 2012. Durante este período foi introduzido um pacote de medidas (grupo estudo) e comparados os resultados nos 6 meses anteriores à sua implementação (grupo de controlo). As medidas consistiram na utilização de conectores de pressão neutra em detrimento dos conectores de pressão positiva, na sua troca mais frequente e numa solução anti-séptica mais eficaz. Foram incluídos neste estudo 116 doentes hematológicos com cateter venoso central de longa duração inserido por um período superior a 72 h. Foram contabilizados 8 867 dias de cateter (6 756 dias de cateter venoso central no grupo estudo e 2 111 dias de cateter venoso central no grupo de controlo). Resultados: Obteve-se uma redução significativa nas taxas de infeções sistémicas e infeções com origem no cateter venoso central. As taxas de infeções sistémicas: [32,69 (grupo de controlo) vs. 9,43 (grupo estudo)], com uma redução de incidência de 71% [risco relativo 0,2886, CI 95% (0,1793 - 0,4647), p < 0,001] e taxas de infeções com origem no cateter venoso central: [17,53 (grupo de controlo) vs. 4,73 (grupo estudo)], com redução de incidência de 71% [risco relativo 0,2936, CI 95% (0,1793 - 0,5615), p < 0,014]. Não foi encontrada diferença significativa (p > 0,05) na contagem de neutrófilos à data da colheita das amostras de hemoculturas entre ambos os grupos: 69% (< 500 neutrófilos/mm3) [71% (grupo estudo) vs. 68% (grupo de controlo)]. Conclusões: A introdução deste pacote de medidas baseado nas variáveis do

  12. Percepção Astronômica de Alunos do Ensino Médio da Rede Estadual de São Paulo

    NASA Astrophysics Data System (ADS)

    de Oliveira, E. F.; Voelzke, M. R.; Amaral, L. H.

    2005-08-01

    Embora a astronomia seja uma das ciências mais antigas da humanidade e muitos dos conceitos astronômicos serem populares, principalmente nesta época de alta globalização do conhecimento por intermédio de eficientes meios de comunicação e de obtenção da informação, notadamente através da internet, observa-se que uma parcela significativa dos estudantes encontra-se à margem dessas informações. O presente trabalho visa analisar o nível de conhecimento básico dos alunos de Ensino Médio da rede estadual da cidade de Suzano quanto aos fenômenos astronômicos que os rodeiam, tais como a sucessão dos dias e das estações do ano, além de questioná-los sobre fatos genéricos tais como: quais são os astros que se encontram mais próximos do planeta Terra, o que vem a ser o Sol, o Big Bang, um ano-luz, uma estrela cadente, a estrela de Bélem e o que ocasionou a extinção dos dinossauros. Para tanto foi elaborado um formulário constando de questões de múltipla escolha, o qual foi aplicado no primeiro colegial noturno da Escola Estadual Batista Renzi. Num espaço amostral de 34 alunos constatou-se que apenas 29,4% compreendiam a sucessão dos dias da semana, que apenas 20,6% explicaram corretamente as estações do ano, que apenas 20,6% tinham idéia de quais são os objetos celestes mais próximos da Terra, em contraposição 67,6% sabiam classificar corretamente o Sol como estrela, 55,9% relacionavam o Big Bang à origem do universo, apenas 20,6% identificavam um ano-luz como unidade de distância, 32,4% reconheciam uma estrela cadente como meteoro, 41,2% consideravam a estrela de Belém como um cometa e 50,0% explicaram corretamente a extinção dos dinossauros. A presente análise será expandida para as demais classes de primeiro colegial, não somente do período noturno, mas também do diurno da Escola Estadual Batista Renzi, bem como o formulário será devidamente ampliado. Já nesta primeira fase nota-se claramente o pequeno discernimento

  13. Algorithm for the early diagnosis of vitamin B12 deficiency in elderly people.

    PubMed

    Palacios, Gonzalo; Sola, Ricardo; Barrios, Laura; Pietrzik, Klaus; Castillo, Manuel J; González-Gross, Marcela

    2013-01-01

    Introducción: Los mayores son una población que presenta un riesgo importante de desarrollar una deficiencia de vitamina B12, pero las concentraciones de cobalamina en suero no reflejan necesariamente un estado abnormal en el estado de B12 . Existen biomarcadores asociados a la vitamina B12: el ácido metilmalónico no está disponible en todos los laboratorios, la holotranscobalamina es poco sensible y la homocisteína presenta una baja especificidad. El objetivo del presente estudio es establecer un algoritmo de diagnóstico mediante el uso de una combinación de estos biomarcadores en lugar de la medición de uno sólo de ellos. Métodos: Se comparó la eficacia diagnóstica de estos marcadores para la detección de deficiencia de vitamina B12 en una población (n = 218) de ancianos institucionalizados (edad media 80 años). Los parámetros bioquímicos, hematológicos y morfológicos fueron utilizados para clasificar a los sujetos con o sin deficiencia de vitamina B12. Resultados: Se establecieron las curvas ROC (Receiver Operating Curves) para determinar la eficacia diagnóstica de cada parámetro, tomado individualmente. El folato sérico tenía la mayor área bajo la curva (0,87) y la homocisteína la más baja (0,67). Se observó que la mejor especificidad la presentaba el folato eritrocitario y el ácido metilmalónico (100% para ambos), pero sus sensibilidades eran muy bajas (17% y 53%, respectivamente). Y se observó que la sensibilidad más alta la presentaba la homocisteína (81%) y el folato sérico (74%), pero en contrapartida una especificidad baja. Cuando se combinaron estos marcadores, iniciando las determinaciones con el folato sérco y eritrocitario, seguido por holotranscobalamina y terminando por las mediciones de ácido metilmalónico, la sensibilidad y especificidad global del algoritmo fueron 100% y 90%, respectivamente. Conclusión: El algoritmo propuesto, que combina la determinación de folato sérico y eritrocitario

  14. [Glycosylated hemoglobin A1c as a diagnostic test for diabetes mellitus in adolescents with overweight and obesity].

    PubMed

    Rivera-Hernández, Aleida; Zurita-Cruz, Jessie Nallely; Garrido-Magaña, Eulalia; Fiorentini-Fayad, Gigliola Margaretta; Nishimura-Meguro, Elisa

    2015-01-01

    Introducción: en 2009 se introdujo un criterio diagnóstico para la diabetes mellitus 2 (DM2) en población adulta, basado en los niveles de hemoglobina glucosilada (HbA1c) mayor o igual a 6.5 %; el punto de corte en población pediátrica podría ser menor. Se buscó determinar la utilidad de este criterio en adolescentes mexicanos con sobrepeso u obesidad. Métodos: se hizo somatometría completa, revisión del estadio de Tanner y presión arterial, glucemia, curva de tolerancia a la glucosa (CTOG) y HbA1c. Se calculó especificidad, sensibilidad, valores predictivos positivos y negativos y curva ROC para el diagnóstico de DM con HbA1c. Resultados: se estudiaron 109 pacientes entre 10 y 16 años referidos por obesidad o sobrepeso más comorbilidades, 58 % mujeres, edad 13 ± 1.74 años, IMC percentil 95.3 y HbA1c 5.73 ± 0.9 %. Se estableció el diagnóstico de DM en 9 casos (8.3 %), prediabetes en 8 (7.3 %) y tolerancia normal a la glucosa en 92 (84.4 %), el promedio de HbA1c fue de 5.6 ± 0.04, 5.7 ± 0.4 y 5.6 ± 0.73 %, respectivamente. La HbA1c mayor o igual a 6.5 % tuvo una sensibilidad de 12.5 %, especificidad de 89.8 %, VPP 10.65 y VPN 14.28. El mejor punto de corte para diagnosticar DM por curva ROC de HbA1c fue de 5.45 %, con sensibilidad de 62.5 % y especificidad de 57.1 %, VPP 2.53 y VPN 33.3. Conclusiones: el nivel de HbA1c mayor o igual a 6.5% tuvo baja sensibilidad y especificidad para diagnosticar DM. Un punto de corte menor es insuficiente para utilizar la HbA1c como criterio diagnóstico.

  15. Disciplines and Professors of Astronomy in Undergraduate Physics Teachers Formation Courses in Brazilian Universities. (Spanish Title: Disciplinas y Profesores de Astronomia en los Cursos de Licenciatura en Física en Las Universidades Brasileñas.) Disciplinas e Professores de Astronomia Nos Cursos de Licenciatura em Física das Universidades Brasileiras

    NASA Astrophysics Data System (ADS)

    Roberto, Artur Justiniano, Jr.; Reis, Thiago Henrique; dos Reis Germinaro, Daniel

    2014-12-01

    This article is the result of a research on basic training in Astronomy in physics degrees that performed the ENADE 2011 national examination. The objective was to identify whether there are disciplines of Astronomy in these courses, whether are mandatory or optional, its workload and when it is offered. The relationship between astronomers, physics degrees and disciplines of Astronomy was investigated. To perform this research we examined the results of ENADE 2011 and also the census of Brazilian Astronomical Society. As a result it is observed that in only 15% of the courses there is a mandatory subject of Astronomy, and therefore there is a high probability that 85% of physics teachers trained in 2011 have not had any discipline of Astronomy during their graduation. In addition, the data collected in this study shows a low number of members of SAB (Sociedade Astronômica Brasileira) among the surveyed courses. We have verified that the presence of astronomers in a given university does not imply to have a mandatory discipline of Astronomy in physics degrees at the same university. Este artículo es el resultado de una investigación sobre la formación básica en Astronomía en los cursos de Profesorado en Física que hicieron el examen nacional ENADE 2011. El objetivo del trabajo fue identificar se existen disciplinas de Astronomía en estos cursos, si son obligatorias u optativas, cuál es su carga horaria y el semestre en que son ofrecidas. Se investigó también la correlación entre astrónomos, los cursos de licenciatura en Física y las disciplinas de Astronomía. Para realizar esta investigación se utilizaron los datos del ENADE 2011 y también del censo de la Astronomía brasileña. Como resultado, se observó que en solo 15% de los cursos existe una disciplina obligatoria de Astronomía y que existe una grande probabilidad de que 85% de los profesores de Física formados en el año de 2011 no hayan cursado ninguna disciplina de Astronomía durante su formación. Aparte de eso, los datos levantados en este trabajo apuntan para un número bajo de afiliados a la SAB (Sociedade Astronômica Brasileira) en los cursos investigados. Se verificó que tener astrónomos en una institución no implica tener una disciplina obligatoria de Astronomía en el curso de licenciatura en Física. Este artigo é o resultado de uma pesquisa sobre a formação básica em Astronomia nos cursos de Licenciatura em Física que fizeram o exame nacional ENADE 2011. O objetivo do trabalho foi identificar se há disciplinas de Astronomia nesses cursos, se ela é obrigatória ou optativa/eletiva, qual a sua carga horária e o período em que é oferecida. Pesquisou-se também a relação entre astrônomos, cursos de Licenciatura em Física e disciplinas de Astronomia. Para realizar essa pesquisa utilizamos os dados do ENADE 2011 e também do censo da Astronomia brasileira. Como resultado, se observa que em apenas 15% dos cursos existe uma disciplina obrigatória de Astronomia e que há uma grande probabilidade de que 85% dos professores de Física formados em 2011 não cursaram nenhuma disciplina de Astronomia durante a graduação. Além disso, os dados levantados nesse trabalho apontam um baixo número de filiados à SAB nos cursos pesquisados. Identifica-se que ter astrônomos na instituição não implica em disciplina obrigatória de Astronomia no curso de Licenciatura em Física.

  16. The void comprises everything - natural philosophy and science in Otto von Guericke's proof of existence of empty and infinite space. (German Title: Alles umfasst es, das Nichts - Naturphilosophie und Naturwissenschaft im Existenzbeweis des leeren und unendlichen Weltraums bei Otto von Guericke)

    NASA Astrophysics Data System (ADS)

    Gabriel, Peter

    Otto von Guericke showed in his book Experimenta nova (ut vocantur) Magdeburgica de vacuo spatio that space is an infinite void. This contribution illustrates how Guericke mixed natural philosophy and natural science in his argumentation with each other.

  17. The απολογητοσ-riddle in Kepler's Astronomia Nova, chapter 57. (German Title: Das απολογητοσ-Rätsel in Keplers Astronomia Nova, Kapitel 57)

    NASA Astrophysics Data System (ADS)

    Kühn, Ernst

    Since 1937, the latin edition of Johannes Kepler's Astronomia Nova (1609) is available as a standard text. Here, in the 57th chapter, the third one of 48 important marginalia of Kepler, is reproduced as ⪉quo;Quae sit genuina et απολογητοσ mensura librationis huijus etc.». The Grecized word «αpi;ολογητοσ» was ignored to a large extent by translators and commentators, and was at least declared enigmatic by Donahue (1992). A look in the original copies of the 1609 edition shows that it is written ατιολογητοσ, not π but a τι. απολογητοσ in KGW is a read error. In the context of Keplers «natural, causal magnet-like forcesraquo; of planetary motion the conjecture αιτιολογητοσ (as a typographical error a ι is omitted) immediately suggests itself: causally, aetiological. This solution of the απολογητοσ riddle indicates the tight brace between the important Chapter 57 of Kepler's celestial physics and and the complete title ASTRONOMIA NOVA ΑΙΤΙΟΛΟΓΗΤΟΣ, SEV PHYSICA COELESTIS etc.

  18. Patrik and Putrik and Clown Ferdl; Findings and Cognition on the Television Perception of Children and Young People Based on the Prize-Winning Programmes of Prix Jeunesse 1966. Publications of the Internationales Zentralinstitut fur das Jugend- und Bildungsfernsehen, Number 3.

    ERIC Educational Resources Information Center

    Griebel, Francine, Ed.; Burger, Anette, Ed.

    The results of an investigation of the reactions of young children (ranging from four to nine years of age) in France, Germany, England, America, and Czechoslovkia to two Prix Jeunesse winning television films are examined in this document. Summarized reports from each of the participating countries for the film "Patrik and Putrik" and,…

  19. Experiment ueber den Einflusse von Metaboliten und Antimetaboliten am Modell von Trichomonas Vaginalis. IV. Mitteilung: Vitamine, die das Wachstum von Trichomonas Vaginalis Beguenstigen (Experiments on the Influence of Metabolites and Antimetabolites on the Model of Trichomonas Vaginalis. IV. Communication: Vitamins Favouring the Growth of Trichomonas Vaginalis),

    DTIC Science & Technology

    A number of vitamins have been investigated for their influence upon Trichomonas vaginalis . At a concentration of 0.20 mg ml vitamin A has...stimulating action upon the growth of Trichomonas vaginalis . Vitamin D2 has been shown to favour Trichomonas multiplication in all experimental series...Vitamin D3 generally favours the Trichomonas vaginalis population. Addition of vitamin E resulted in enhanced multiplication of Trichomonas and longer

  20. Hilft es die Regel zu wissen um sie anzuwenden? Das Verhaltnis von Melatlinguistischem Bewusstsein und grammatischer Kompetenz (Is Knowledge of Grammar Rules Helpful in Their Application? The Relationship between Metalinguistic Insight and Grammar Competency in the Study of German as a Foreign Language).

    ERIC Educational Resources Information Center

    Schultz, Renate A.

    2002-01-01

    Examines to what extent, if at all, grammar instruction fosters or accelerates language acquisition. Presents a study investigating the acquisition of syntactic or morphological structures in 340 students learning German as a foreign language. The results are discussed. (AS)

  1. 50 CFR 648.262 - Effort-control program for red crab limited access vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... holders by letter of the newly calculated DAS allocation. (2) For fishing year 2010 and thereafter. Each... DAS (48 hours) for the fishing trip, even though the trip lasted only 23 hours. (4) Good...

  2. Comparison of the Disease Activity Score using Erythrocyte Sedimentation Rate and C-reactive Protein in African-Americans with Rheumatoid Arthritis

    PubMed Central

    Tamhane, Ashutosh; Redden, David T.; McGwin, Gerald; Brown, Elizabeth E.; Westfall, Andrew O.; Reynolds, Richard J.; Hughes, Laura B.; Conn, Doyt L.; Callahan, Leigh F.; Jonas, Beth L.; Smith, Edwin A.; Brasington, Richard D.; Moreland, Larry W.; Bridges, S. Louis

    2014-01-01

    INTRODUCTION The Disease Activity Score based on 28 joints (DAS28) has been increasingly used in clinical practice and research studies of rheumatoid arthritis (RA). Studies have reported discordance between DAS28 based on erythrocyte sedimentation rate (ESR) versus C-reactive protein (CRP) in RA patients. However such comparison is lacking in African-Americans with RA. METHODS This analysis included participants from the Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis (CLEAR) Registry which enrolls self-declared African-Americans with RA. Using tender and swollen joint counts separate ESR-based and CRP-based DAS28 scores (DAS28-ESR3 and DAS28-CRP3) were calculated, as were DAS28-ESR4 and DAS28-CRP4, which included the patient’s assessment of disease activity. The scores were compared using paired t-test, simple agreement and kappa, correlation coefficient and Bland-Altman plots. RESULTS Of the 233 included participants, 85% were women, mean age at enrollment was 52.6 years, and median disease duration at enrollment was 21 months. Mean DAS28-ESR3 was significantly higher than DAS28-CRP3 (4.8 vs. 3.9; p<0.001). Similarly, mean DAS28-ESR4 was significantly higher than DAS28-CRP4 (4.7 vs. 3.9; p<0.001). ESR-based DAS28 remained higher than CRP-based DAS28 even when stratified by age, sex, and disease duration. Overall agreement was not high between DAS28-ESR3 and DAS28-CRP3 (50%) or between DAS28-ESR4 and DAS28-CRP4 (59%). DAS28-CRP3 underestimated disease activity in 47% of the participants relative to DAS28-ESR3 and DAS28-CRP4 in 40% of the participants relative to DAS28-ESR4. CONCLUSION There was significant discordance between the ESR-based and CRP-based DAS28 which could impact clinical treatment decisions in African-Americans with RA. PMID:23950187

  3. 50 CFR 648.92 - Effort-control program for monkfish limited access vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... are adjusted to account for the approval of multi-year awards. (iv) Research projects shall be... reduced by the amount calculated in paragraph (b)(1)(v) of this section for the research DAS set-aside... § 648.95(g)(2). (v) Research DAS set-aside. A total of 500 DAS shall be set aside and made available...

  4. “&ldots;how the right technique emerged at the right time” Zur Geschichte der fotografischen Methode im Kalten Krieg

    NASA Astrophysics Data System (ADS)

    Fengler, Silke

    Die Frühgeschichte der fotografischen Methode, die als Nachweisinstrument kernphysikalischer und kosmischer Strahlung in den 1950er Jahren zur Blüte kam, hat das Interesse vieler Wissenschaftshistoriker gefunden. Peter Galison hat gezeigt, wie fragil das Experimentalsystem lange Zeit war, das sich um die Methode bildete, und wie prekär die mit ihr aufgezeichneten Ergebnisse.

  5. 75 FR 3234 - Issuance of an Experimental Use Permit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... allows the use of the following plant-incorporated protectants: 1. Bacillus thuringiensis Cry1F protein... [Organization for Economic Cooperation and Development (OECD) Unique Identifier: DAS-01507-1] 2. Bacillus... production in corn event DAS-59122-7 (OECD Unique Identifier: DAS-59122-7) 3. Bacillus thuringiensis...

  6. Efficiently Assessing Negative Cognition in Depression: An Item Response Theory Analysis of the Dysfunctional Attitude Scale

    ERIC Educational Resources Information Center

    Beevers, Christopher G.; Strong, David R.; Meyer, Bjorn; Pilkonis, Paul A.; Miller, Ivan R.

    2007-01-01

    Despite a central role for dysfunctional attitudes in cognitive theories of depression and the widespread use of the Dysfunctional Attitude Scale, form A (DAS-A; A. Weissman, 1979), the psychometric development of the DAS-A has been relatively limited. The authors used nonparametric item response theory methods to examine the DAS-A items and…

  7. Development and Validation of the Dysfunctional Attitude Scale: A Preliminary Investigation.

    ERIC Educational Resources Information Center

    Weissman, Arlene N.; Beck, Aaron T.

    The Dysfunctional Attitude Scale (DAS) was developed to measure pervasive negative attitudes of a depressed person towards self, outside world, and future. The DAS follows Beck's construct of cognitive dysfunction. Two studies investigated the psychometric properties of the DAS and the relationship between cognition and affect in 300 normal…

  8. 77 FR 41361 - Dow AgroSciences LLC; Availability of Petition for Determination of Nonregulated Status of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... Determination of Nonregulated Status of Soybean Genetically Engineered for Herbicide Tolerance AGENCY: Animal... LLC (DAS) seeking a determination of nonregulated status of soybean designated as DAS-44406-6, which... soybean (Glycine max) designated as event DAS-44406-6, which has been genetically engineered for...

  9. Astronomical Perception of the Secondary School's Students in São Paulo's State School in Suzano City. (Spanish Title: Percepción Astronómica de Alumnos de la Enseñanza Media de la Red Estatal de San Pablo en la Ciudad de Suzano.) Percepção Astronômica de um Grupo de Alunos do Ensino Médio da Rede Estadual de São Paulo da Cidade de Suzano

    NASA Astrophysics Data System (ADS)

    França de Oliveira, Edilene; Voelzke, Marcos Rincon; Amaral, Luis Henrique

    2007-12-01

    año y 20,6% tenían la idea de cuales son los objetos celestes más cercanos de la Tierra. En contraposición, 67,6% clasificaron correctamente el Sol como una estrella; 55,9% relacionaron el Big Bang al origen del Universo; solamente 20,6% identificaron un año-luz como unidad de distancia y 32,4% reconocieron una estrella fugaz como meteoro. El presente análisis fue expandido para otros grupos de la Enseñanza Media, no solamente del período nocturno, sino también diurno de la misma escuela. En esta primera fase se nota el pequeño conocimiento de los alumnos sobre eventos astronómicos y principalmente la gran confusión sobre el significado correcto de los términos astronómicos populares. Embora a Astronomia seja uma das ciências mais antigas da humanidade e muitos dos conceitos astronômicos serem populares, observa-se que uma parcela significativa dos estudantes encontra-se à margem dessas informações. O presente trabalho visa analisar o nível de conhecimento básico dos alunos do Ensino Médio da Rede Estadual da cidade de Suzano quanto aos fenômenos astronômicos que os rodeiam. Para tanto foi elaborado um formulário constando de questões de múltipla escolha, aplicado no primeiro ano noturno da Escola Estadual Batista Renzi. Num espaço amostral de 34 alunos constatou-se que apenas 29,4% compreendiam a sucessão dos dias; 20,6% explicaram corretamente as estações do ano e 20,6% tinham idéia de quais são os objetos celestes mais próximos da Terra. Em contraposição, 67,6% classificaram corretamente o Sol como estrela; 55,9% relacionaram o Big Bang à origem do Universo; apenas 20,6% identificaram um ano-luz como unidade de distância e 32,4% reconheceram uma estrela cadente como meteoro. A presente análise foi expandida para mais 310 alunos de outras classes de Ensino Médio, não somente do período noturno, mas também diurno da mesma escola. Nesta primeira fase nota-se o pequeno discernimento dos alunos sobre eventos astronômicos e

  10. Is duration of postoperative fasting associated with infection and prolonged length of stay in surgical patients?

    PubMed

    de Assis, Michelli Cristina Silva; Silveira, Carla Rosane de Moraes; Beghetto, Mariur Gomes; de Mello, Daniel Elza

    2014-10-01

    Objetivo: Constatar si el periodo de ayuno postoperatorio aumenta el riesgo de infeccion y prolonga la estancia hospitalaria. Métodos: Estudio de cohorte prospectivo. Fueron incluidos pacientes en cirugia selectiva. Se excluyeron aquellos sin posibilidades de evaluacion nutricional, ingresados a unidades de cuidado minimo y con.

  11. Cystogram

    MedlinePlus

    ... de Usted sentirá presión y plenitud en la rayos X de la vejiga urinaria, ubicada vejiga y sentirá ... a menudo para diagnosticar un una unidad de rayos X conectada a problema llamado reflujo. El reflujo una ...

  12. National Security Policy and Security Challenges of Maldives

    DTIC Science & Technology

    2014-06-13

    Investigaciones Sobre Seguridad y Cooperacion International Discussion Paper, “Terrorism and Extremism; A Threat to Maldives Tourism Industry,” 1...28 June 2012. http://www.haveeru.com.mv/news/43011(accessed 2 June 2014). Niyaz, Ali. Mazlan and Murad Law Associates. Unidad de Investigaciones

  13. Optical Fibre Embedded in a Composite Laminated with Applications to Sensing

    DTIC Science & Technology

    2000-09-29

    Porto - Unidade de Optoelectr6nica e Sistemas Electr6nicos, Rua Campo Alegre, 687, 4169 - 007 Porto, Portugal, Tel.: +351 226 082 601; Fax: +351 226 082...mu’) Fig. 2 Response of smart sensor plate to: a) Temperature; b) Inverse curvature radius (l/R). 291 As expected different sensitivities were

  14. [Peritoneal Dialysis in the First Two Years of Life: Experience of a Nephrology and Renal Transplantation Pediatric Unit].

    PubMed

    Deuchande, Sofia; Mano, Tânia; Novais, Cristina; Machado, Rute; Stone, Rosário; Almeida, Margarida

    2016-09-01

    Introdução: A diálise peritoneal é o método dialítico de eleição perante doença renal crónica terminal em idade pediátrica. O objetivo deste estudo foi caracterizar a sobrevivência a longo prazo de uma população de crianças, que iniciou diálise peritoneal nos dois primeiros anos de vida. Material e Métodos: Estudo descritivo e retrospetivo, realizado numa unidade de nefrologia e transplantação renal pediátrica portuguesa, no período de janeiro de 1991 a agosto de 2014. Avaliou-se etiologia da doença renal crónica terminal, mortalidade, comorbilidades e complicações da diálise peritoneal e da doença renal crónica terminal, crescimento e desenvolvimento psicomotor.Resultados: Vinte crianças iniciaram diálise peritoneal antes dos dois anos. Ocorreram seis óbitos; não houve mortalidade em crianças com doença renal primária nos últimos 10 anos. Caracterizaram-se os 14 sobreviventes, 13 do sexo masculino. As anomalias congénitas do rim e do trato urinário constituíram a principal causa de doença renal crónica terminal (45%).O início de diálise peritoneal ocorreu em média aos 6,1 meses, em seis casos antes dos 30 dias de vida. A peritonite foi o motivo mais frequente de internamento. Dez crianças foram transplantadas, com idade média de 5,3 anos. Em relação ao crescimento, as quatro crianças que se mantêm em diálise peritoneal têm baixa estatura, mas nove dos transplantados têm uma estatura final dentro do esperado para a sua estatura-alvo familiar. Nove (64%) tiveram alterações no desenvolvimento psicomotor. Discussão: A diálise peritoneal é uma técnica possível e exequível desde o nascimento, tal como evidenciado nesta amostra, em que se iniciou com sucesso em mais de metade das crianças antes dos seis meses de vida. Permite uma sobrevivência a longo prazo até à possibilidade do transplante renal apesar da morbilidade associada, nomeadamente as peritonites e as complicações da doença renal

  15. [Multidimensional Strategy Regarding the Reduction of Central-Line Associated Infection in Pediatric Intensive Care].

    PubMed

    Rodrigues, Jorge; Dias, Andrea; Oliveira, Guiomar; Farela Neves, José

    2016-06-01

    Introdução: Determinar a incidência de infeções da corrente sanguínea associadas ao uso de cateter venoso central, após reforço de medidas multidisciplinares de boa prática e a sua comparação com a taxa de incidência de infeções da corrente sanguínea associadas ao uso de cateter venoso central prévia. Material e Métodos: Estudo observacional descritivo, com colheita prospetiva de dados, durante cinco meses, após implementação de medidas multidisciplinares. Foram incluídas todas as crianças admitidas na unidade de Cuidados Intensivos Pediátricos, submetidas à colocação de cateter venoso central e foi efetuada comparação com controlos históricos.Resultados: Incluíram-se 75 doentes com idade mediana de 23 meses: 22 (29,3%) recém-nascidos, 28 (37,3%) submetidos a cirurgia e 32 (43,8%) com patologia subjacente. Foram colocados 105 cateteres venosos centrais, com tempo médio de permanência de 6,8 ± 6,7 dias. O tipo de cateter venoso central mais comum foi de curta duração (45,7%), sendo os locais de inserção mais frequentes a veia subclávia e da flexura braquial (ambos 25,7%). Não ocorreu nenhuma infeção da corrente sanguínea associada ao uso de cateter venoso central durante o período do estudo. Comparando com os controlos históricos, ambos os grupos eram semelhantes relativamente à idade, género, proveniência dos doentes e local de colocação de cateter venoso central. No estudo atual, a duração mediana de internamento foi superior, com tempo de permanência de cateter venoso central (excluindo epicutâneo-cava) semelhante. Não se verificou diferença em relação ao calibre e número de lumens do cateter venoso central utilizado. A percentagem de crianças que colocou cateter venoso central em relação ao total de crianças admitidas no serviço no mesmo período foi menor no estudo atual, não existindo diferença significativa entre colocação de cateter venoso central único ou múltiplo. Discussão: Ap

  16. Thyroid carcinoma in children and young adults: retrospective review of 19 cases.

    PubMed

    Saraiva, Joana; Ribeiro, Cristina; Melo, Miguel; Gomes, Leonor; Costa, Gracinda; Carrilho, Francisco

    2013-01-01

    Introdução: O carcinoma da tiróide é raro em crianças e em adultos jovens. A maior parte das orientações clínicas baseia-se em dados obtidos na população adulta. Persistem diversas controvérsias no que se refere à agressividade da apresentação clínica e da abordagem terapêutica.Objectivo: Avaliar todos os doentes com carcinoma da tiróide com menos de 20 anos no momento da apresentação, reflectindo a experiência da nossa unidade relativamente ao diagnóstico, tratamento e seguimento desta entidade.Material e Métodos: Trata-se de um estudo de revisão retrospectiva dos registos clínicos de todas as crianças e adultos jovens seguidos na Consulta de Oncologia do Serviço de Endocrinologia do Centro Hospitalar e Universitário de Coimbra entre 1996 e 2012 .Resultados: Foram estudados 19 doentes, com uma média etária de 16 anos, sendo 13 do sexo feminino. Nenhum dos doentes fora previamente submetido a irradiação da região do pescoço. A queixa de apresentação era a presença de uma massa cervical palpável em 84,6% dos casos. Foi realizada citologia aspirativa em 15 doentes, que foi diagnóstica ou suspeita de neoplasia em 71,4% dos casos. A tiroidectomia total foi levada a cabo em 18 casos (94,7%). Em todos estes foi identificada a presença de um carcinoma papilar. A invasão vascular e multicêntrica ocorreu em 21,1% dos casos. A dimensão tumoral média foi de 2,5 cm. O envolvimento ganglionar cervical foi diagnosticado em 31,6% dos casos e a presença de metástases à distância foi identificada em 5,2% dos casos. Na maior parte dos doentes (18 em 19), o quadro foi classificado como doença em estadio I. Todos os doentes fizeram terapêutica supressora com tiroxina e 84,2% dos doentes foram submetidos a ablação pós-operatória com iodo radioactivo (dose média de 85,7mCi). Durante um seguimento médio de cerca de 6 anos, 16 doentes permaneceram em remissão.Conclusão: Na nossa série, as taxas de metastização ganglionar cervical

  17. Analysis of Service-learning activities adopted in health courses of Federal University of Bahia.

    PubMed

    Baldoino, Aline Silva; Veras, Renata Meira

    2016-06-01

    is study aimed to raise and discuss the data about the integration of health courses teaching and service activities o ered at the Federal University of Bahia (UFBA), pre- senting scenarios practices and major di culties existing in the relationship between the university and the services of health. is was a qualitative study of descriptive explo- ratory character, using a questionnaire as a research tool applied to the coordinators of selected health courses. e selection was by reading the political pedagogical project, the following courses were selected: nursing, physical therapy, speech therapy, medicine, nu- trition, dentistry and public health. e results indicated eight types of teaching-service integration activities, 57 scenarios of practice and the main di culties. It was concluded that these courses are sticking to changes in academic training in health, in view of the large number of basic health units in the teaching service process. us, it emphasizes that the UFBA includes activities in health care that enable the integration-education in the higher education process, although there are some di culties in this relationship indicated by the coordinators. Esse estudo teve como objetivo levantar e discutir os dados acerca das atividades de integração ensino-serviço de cursos de saúde oferecidos na Universidade Federal da Bahia (UFBA), apresentando os cenários de práticas e as principais di culdades existentes na relação entre a uni- versidadeeosserviçosdesaúde.Tratou-sedeumapesquisaqualitativa,decaráterdescritivoexploratório,utilizando-seumquestionáriocomo instrumento de investigação aplicado aos coordenadores dos cursos de saúde selecionados. A seleção foi mediante a leitura do projeto político pedagógico, sendo selecionados os seguintes cursos: enfermagem, sioterapia, fonoaudiologia, medicina, nutrição, odontologia e saúde coletiva. Os resultados indicaram 8 tipos de atividades de integração ensino-serviço, 57 cenários de pr

  18. [Postoperative recovery of blood in patients undergoing total knee or hip arthroplasty].

    PubMed

    Laranjeira, Hugo; Coimbra, Celeste; Fernandes, Nuno; Pinho, Romeu; Anjos, Rui; Mesquita, Elisabeth; Barros, António; Ferreira, Rita; Borges, Lúcia

    2013-01-01

    Introdução: Na artroplastia total do joelho e na artroplastia total da anca ocorrem perdas de sangue consideráveis, sendo necessário recorrer frequentemente a transfusões de concentrado de eritrócitos. No entanto, para além dos potenciais riscos inerentes, o sangue homólogo é um recurso limitado e caro. No sentido de reduzir o recurso a transfusões homólogas, tem-se desenvolvido estratégias alternativas, como a recuperação pós-operatória de sangue.Objetivos: Avaliação da implementação da recuperação pós-operatória de sangue no consumo de concentrado de eritrócitos no período pós-operatório e no tempo de internamento, pela avaliação retrospetiva de doentes submetidos a artroplastia total do joelho ou a artroplastia total da anca.Material e Métodos: Os 976 doentes foram divididos em 2 grupos: CELL TRANS – doentes submetidos à intervenção após a implementação da recuperação pós-operatória de sangue e CONT – submetidos à intervenção antes da implementação da estratégia referida. O número de unidades de concentrado de eritrócitos administradas foi obtido pela análise das requisições ao Serviço de Imunohemoterapia e o tempo de internamento foi obtido através do Sistema de Apoio ao Médico. A análise estatística foi realizada com recurso à linguagem R, considerando-se diferenças significativas entre os grupos quando p < 0,05.Resultados: Após a introdução da recuperação pós-operatória de sangue, 29% dos doentes submetidos a artroplastia total do joelho e 38% dos doentes submetidos a artroplastia total da anca receberam concentrado de eritrócitos no período pós-operatório, um número consideravelmente menor ao observado antes da implementação da estratégia, 68% e 59% respetivamente. Concomitantemente, verificou-se uma redução estatisticamente significativa no tempo de internamento de 9,0 para 8,3 dias para o caso dos doentes submetidos a artroplastia total do joelho e de 9,1 para 8,8 dias para o

  19. Dasatinib-loaded albumin nanoparticles possess diminished endothelial cell barrier disruption and retain potent anti-leukemia cell activity

    PubMed Central

    Li, Zhenyu; Shetty, Sreerama; Fu, Jian

    2016-01-01

    Dasatinib (DAS), a second-generation tyrosine kinase inhibitor, is highly effective in treating chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. However, its clinical use is limited due to serious adverse effects. DAS can disrupt endothelial barrier integrity and increase endothelial permeability which may cause peripheral edema and pleural effusion. Albumin nanoparticles (NPs) as a drug carrier may serve as a useful tool for cell-selective drug delivery to reduce DAS-induced endothelial hyperpermeability and maintain endothelial barrier integrity. In this study, we reported that DAS-loaded NPs exhibited potent anti-leukemia efficacy as DAS alone. Importantly, albumin NPs as a drug carrier markedly reduced DAS-induced endothelial hyperpermeability by restraining the inhibition of Lyn kinase signaling pathway in endothelial cells. Therefore, albumin NPs could be a potential tool to improve anti-leukemia efficacy of DAS through its cell-selective effects. PMID:27391073

  20. Diallyl sulfide induces the expression of nucleotide excision repair enzymes in the breast of female ACI rats.

    PubMed

    Green, Mario; Newell, Oneil; Aboyade-Cole, Ayoola; Darling-Reed, Selina; Thomas, Ronald D

    2007-01-10

    Diethylstilbestrol (DES) causes DNA adducts resulting in breast cancer, whereas diallyl sulfide (DAS) inhibits cancer formation. We hypothesize that DAS induces the expression of nucleotide excision repair genes. To test this hypothesis, female ACI rats were treated for 4 days with corn oil, DES, DAS, and DAS/DES (50mg/kg). The expression of P53, Gadd45a, PCNA, and DNA polymerase delta was analyzed by real-time PCR. DES decreased the expression of P53, Gadd45a and PCNA. DAS and DAS/DES increased the expression of all four genes. These results suggest that DAS enhances the ability of breast tissue to repair DNA damage thus preventing cancer.

  1. Diallyl sulfide induces the expression of estrogen metabolizing genes in the presence and/or absence of diethylstilbestrol in the breast of female ACI rats.

    PubMed

    Green, Mario; Newell, Oneil; Aboyade-Cole, Ayoola; Darling-Reed, Selina; Thomas, Ronald D

    2007-01-10

    Diethylstilbestrol (DES) induces mammary tumors in female ACI rats and is associated with an increased risk of developing breast cancer in humans. Diallyl sulfide (DAS) has been shown to prevent cancer in animals. Previously, we have shown that DAS inhibits the production of DES induced DNA adducts when given prior to DES. We hypothesize that DAS alters the expression of genes responsible for DES metabolism. To test this hypothesis, four groups of 10 female ACI rats were treated daily for four days as follows: (1) corn oil, (2) 50mg/kg DES, (3) 50mg/kg DAS, and (4) 50mg/kg DAS+50mg/kg DES. RNA was isolated from breast tissue and mRNA levels of CYP1A1, CYP1B1, glutathione-S-transferase (GST) and superoxide dismutase (SOD) were analyzed by real-time PCR. DES, DAS, and DES/DAS treatments increased the expression of CYP1A1 by 2.1-, 4.7-, and 12.7-fold, respectively. Similar results were seen for CYP1B1. DES decreased the expression of GST by 23%, whereas DAS and DAS/DES treatments increased the expression of GST by 12- and 16.7-fold, respectively. Similar results were seen with SOD. These results suggests that DAS may prevent the formation of DES induced DNA damage by altering the expression of DES metabolizing genes.

  2. Protective effects of diallyl sulfide on acetaminophen-induced toxicities.

    PubMed

    Hu, J J; Yoo, J S; Lin, M; Wang, E J; Yang, C S

    1996-10-01

    Diallyl sulfide (DAS), a major flavour component of garlic, is known to modulate drug metabolism and may protect animals from chemically induced toxicity and carcinogenesis. In this study the effects of DAS on the oxidative metabolism and hepatotoxicity induced by acetaminophen (APAP) in rats were investigated. In the hepatotoxicity evaluation of Fischer 344 rats there was a dose-dependent increase in the odds of mortality rate by APAP (P = 0.009); DAS treatment significantly protected rats from APAP-related mortality (P = 0.026). Liver toxicity determined by lactate dehydrogenase activity was significantly increased by APAP treatment (0.75 g/kg). Pretreatment with DAS protected animals from APAP-induced liver toxicity in a time- and dose-dependent fashion. Treatment of DAS (50 mg/kg) 3 hr after APAP dosing significantly (P < 0.05) protected rats from APAP-induced liver toxicity. The metabolism of APAP (50 microM) in vitro was significantly inhibited by DAS (0.3-1 mM) in liver microsomes isolated from F344 rats. As the effect of DAS on APAP-induced hepatotoxicity in vivo was observed only when DAS was administered before or shortly after (< 3 hr) APAP dosing, data suggested that the protective effect of DAS is mainly at the metabolic activation step of APAP. However, the possibility that DAS may also have effects on other drug metabolism systems, such as glutathione (GSH) and glutathione S-transferases, cannot be ruled out.

  3. Transcriptional activation of the herpes simplex virus type 1 UL38 promoter conferred by the cis-acting downstream activation sequence is mediated by a cellular transcription factor.

    PubMed

    Guzowski, J F; Singh, J; Wagner, E K

    1994-12-01

    The herpes simplex virus (HSV) type 1 strict late (gamma) UL38 promoter contains three cis-acting transcriptional elements: a TATA box, a specific initiator element, and the downstream activation sequence (DAS). DAS is located between positions +20 and +33 within the 5' untranslated leader region and strongly influences transcript levels during productive infection. In this communication, we further characterize DAS and investigate its mechanism of action. DAS function has a strict spacing requirement, and DAS contains an essential 6-bp core element. A similarly positioned element from the gamma gC gene (UL44) has partial DAS function within the UL38 promoter context, and the promoter controlling expression of the gamma US11 transcript contains an identically located element with functional and sequence similarity to UL38 DAS. These data suggest that downstream elements are a common feature of many HSV gamma promoters. Results with recombinant viruses containing modifications of the TATA box or initiator element of the UL38 promoter suggest that DAS functions to increase transcription initiation and not the efficiency of transcription elongation. In vitro transcription assays using uninfected HeLa nuclear extracts show that, as in productive infection with recombinant viruses, the deletion of DAS from the UL38 promoter dramatically decreases RNA expression. Finally, electrophoretic mobility shift assays and UV cross-linking experiments show that DAS DNA forms a specific, stable complex with a cellular protein (the DAS-binding factor) of approximately 35 kDa. These data strongly suggest that the interaction of cellular DAS-binding factor with DAS is required for efficient expression of UL38 and other HSV late genes.

  4. [Validation of a diagnostic questionnaire of allergic rhinitis in children and adults for epidemiological studies].

    PubMed

    Mancilla-Hernández, Eleazar; Medina-Ávalos, Miguel A; Osorio-Escamilla, Roberto E

    2014-01-01

    Antecedentes: la rinitis alérgica es la enfermedad alérgica más frecuente, se distingue por rinorrea, congestión nasal y estornudos, inducidos por una respuesta mediada por IgE. Objetivo: validar un cuestionario para diagnóstico clínico de rinitis alérgica. Material y método: prueba de una prueba en la que se elaboró un cuestionario para el diagnóstico clínico de rinitis alérgica. Se incluyeron 300 pacientes de uno y otro sexo, 150 niños y 150 adultos, atendidos en consultorios de alergia, de noviembre de 2012 a febrero de 2014. La mitad fueron casos de rinitis alérgica y la mitad controles sin rinitis alérgica. Los límites de edad fueron 2 y 70 años. En el grupo de niños de 12 años y menores, el cuestionario se aplicó a los padres. Durante este tiempo se realizaron las pruebas de validación de los cuestionarios. Resultados: las pruebas aplicadas a las respuestas del cuestionario mostraron en adultos y en los niños buena concordancia en la prueba-reprueba y en la concordancia interobservador (evaluación de dos médicos), que fue de sustancial a casi perfecta. Las pruebas aplicadas para validez de criterio en el cuestionario de adultos tuvieron sensibilidad de 91%, especificidad de 89%, valor predictivo positivo de 89% y valor predictivo negativo de 92%. En el cuestionario para padres, la sensibilidad fue de 94%, la especificidad de 93%, valor predictivo positivo de 93% y valor predictivo negativo de 94% y los criterios para validez de contenido y de expresión se cumplieron adecuadamente. La prueba de homogeneidad alcanzó un puntaje de 0.7 (alfa de Cronbach). Conclusión: el cuestionario para diagnóstico de rinitis alérgica de adultos y niños tiene buena concordancia intra e interobservador, con alta sensibilidad y especificidad en la validez de criterio, y puntaje aceptable en la prueba de homogeneidad.

  5. Modellierung und Simulation des Substrat-Rauschens in integrierten RF CMOS-Schaltungen

    NASA Astrophysics Data System (ADS)

    Lin, L.; Xiong, J.; Mathis, W.

    2009-05-01

    Im integrierten CMOS-Schaltungsentwurf kann das Substrat-Rauschen, das vom digitalen Teil entsteht, die Funktionalität des analogen Teils stark beeinflussen. Es wird daher immer wichtiger, das Substrat als ein Medium der Rauschen-Propagation genau zu modellieren. Im vorliegenden Artikel wird ein auf der Finite Elemente Methode (FEM) und Modellordnungsreduktion (MOR) basiertes Modellierungsverfahren zur Admittanzen-Extraktion im Halbleitersubstrat vorgestellt. Nach der Diskretisierung mit FEM wird das Substrat im Allgemeinen als ein resistives/kapazitives Netz angesehen. Durch Bestimmung der Admittanz-Matrix und MOR ist es möglich ein äquivalentes Dreipol-Modell zwischen digitalem und analogem Teil über das Substrat zu bilden. Das Ergebnis der Modellierung wird dargestellt und mit numerischer Simulation des Substrat-Rauschens verglichen. Die Modellierung ermöglicht es, die Einflüsse des Substrat-Rauschens im Schaltungsentwurf zu berücksichtigen und so bestehende CMOS-Schaltungsarchitekturen zu optimieren.

  6. No further gain can be achieved by calculating Disease Activity Score in 28 joints with high-sensitivity assay of C-reactive protein because of high intraindividual variability of C-reactive protein

    PubMed Central

    Hansen, Inger M.J.; Emamifar, Amir; Andreasen, Rikke A.; Antonsen, Steen

    2017-01-01

    Abstract Disease Activity Score in 28 joints (DAS28) is commonly used to evaluate disease activity of rheumatoid arthritis (RA) and is a guide to treatment decision. The aim of this study was to evaluate the impact of lower reporting limit for C-reactive protein (CRP), with respect to intraindividual biological variability, on the calculation of DAS28 and subsequent patient classification. This study consists of 2 sections: a theoretical consideration discussing the performance of CRP in calculating DAS28 taking intraindividual biological variation and lower reporting limit for CRP into account and a cross-sectional study of RA patients applying our theoretical results. Therefore, we calculated DAS28 twice, with the actual CRP values and CRP = 9 mg/L, the latter to elucidate the positive effects of reducing the lower reporting limit of CRP from <10 to <3 mg/L. Lower-reporting limit of <10 mg/L leads to overestimate DAS28. However, reducing lower reporting limit for CRP to <3 mg/L results in optimizing DAS28 calculation. Further lowering of reporting limit for CRP to <3 mg/L does not increase the precision of DAS28 owing to the relatively large intraindividual biological variation. Five hundred twelve patients were included. There was a significant difference between recalculated and patients DAS28 (P < 0.001). One hundred nine patients had DAS28 deviation (compatible to remission to low: 66, low to moderate: 39. and moderate to high: 4). Owing to significant impact of intraindividual biologic variation on DAS28 and patient classification, special attention should be paid to calculate DAS28 when CRP values are within normal range. Furthermore, we conclude that results of different studies evaluating DAS28 and treatment response are not comparable if the reporting limits of CRP are unknown. PMID:28072726

  7. No further gain can be achieved by calculating Disease Activity Score in 28 joints with high-sensitivity assay of C-reactive protein because of high intraindividual variability of C-reactive protein: A cross-sectional study and theoretical consideration.

    PubMed

    Hansen, Inger M J; Emamifar, Amir; Andreasen, Rikke A; Antonsen, Steen

    2017-01-01

    Disease Activity Score in 28 joints (DAS28) is commonly used to evaluate disease activity of rheumatoid arthritis (RA) and is a guide to treatment decision.The aim of this study was to evaluate the impact of lower reporting limit for C-reactive protein (CRP), with respect to intraindividual biological variability, on the calculation of DAS28 and subsequent patient classification.This study consists of 2 sections: a theoretical consideration discussing the performance of CRP in calculating DAS28 taking intraindividual biological variation and lower reporting limit for CRP into account and a cross-sectional study of RA patients applying our theoretical results. Therefore, we calculated DAS28 twice, with the actual CRP values and CRP = 9 mg/L, the latter to elucidate the positive effects of reducing the lower reporting limit of CRP from <10 to <3 mg/L.Lower-reporting limit of <10 mg/L leads to overestimate DAS28. However, reducing lower reporting limit for CRP to <3 mg/L results in optimizing DAS28 calculation. Further lowering of reporting limit for CRP to <3 mg/L does not increase the precision of DAS28 owing to the relatively large intraindividual biological variation.Five hundred twelve patients were included. There was a significant difference between recalculated and patients DAS28 (P < 0.001). One hundred nine patients had DAS28 deviation (compatible to remission to low: 66, low to moderate: 39. and moderate to high: 4).Owing to significant impact of intraindividual biologic variation on DAS28 and patient classification, special attention should be paid to calculate DAS28 when CRP values are within normal range. Furthermore, we conclude that results of different studies evaluating DAS28 and treatment response are not comparable if the reporting limits of CRP are unknown.

  8. Studying at the Universities of the Armed Forces: Comparative Results from the 1999 Student Questionnaire (Studieren an den UniBw: Vergleichende Ergebnisse aus der Studentenbefragung 1999)

    DTIC Science & Technology

    2002-12-01

    distanziert kollegial UniBw Miinchen: Auf den ersten Blick scheint das allgemeine Kommunikationsgeschehen in M • nchen im Prinzip dem an der Hamburger UniBw...Hochschulforschung m )chten wir an dieser Stelle danken fMr das Oberlassen des Frageinstrumen- tariums, das dem ZHQ zur Nutzung fu-r die eigene...gerweise war schon im Grandungskonzept der UniBw diesem Moment einer m ~glichst nahen, en- gen und transparenten Kommunikation besondere Beachtung

  9. In vitro efficacy of diallyl sulfides against the periodontopathogen Aggregatibacter actinomycetemcomitans.

    PubMed

    Velliyagounder, Kabilan; Ganeshnarayan, Krishnaraj; Velusamy, Senthil Kumar; Fine, Daniel H

    2012-05-01

    The in vitro antibacterial effects of diallyl sulfide (DAS) against the Gram-negative periodontopathogen Aggregatibacter actinomycetemcomitans, the key etiologic agent of the severe form of localized aggressive periodontitis and other nonoral infections, were studied. A. actinomycetemcomitans was treated with garlic extract, allicin, or DAS, and the anti-A. actinomycetemcomitans effects of the treatment were evaluated. Garlic extract, allicin, and DAS significantly inhibited the growth of A. actinomycetemcomitans (greater than 3 log; P < 0.01) compared to control cells. Heat inactivation of the garlic extracts significantly reduced the protein concentration; however, the antimicrobial effect was retained. Purified proteins from garlic extract did not exhibit antimicrobial activity. Allicin lost all its antimicrobial effect when it was subjected to heat treatment, whereas DAS demonstrated an antimicrobial effect similar to that of the garlic extract, suggesting that the antimicrobial activity of garlic extract is mainly due to DAS. An A. actinomycetemcomitans biofilm-killing assay performed with DAS showed a significant reduction in biofilm cell numbers, as evidenced by both confocal microscopy and culture. Scanning electron microscopy (SEM) analysis of DAS-treated A. actinomycetemcomitans biofilms showed alterations of colony architecture indicating severe stress. Flow cytometry analysis of OBA9 cells did not demonstrate apoptosis or cell cycle arrest at therapeutic concentrations of DAS (0.01 and 0.1 μg/ml). DAS-treated A. actinomycetemcomitans cells demonstrated complete inhibition of glutathione (GSH) S-transferase (GST) activity. However, OBA9 cells, when exposed to DAS at similar concentrations, showed no significant differences in GST activity, suggesting that DAS-induced GST inhibition might be involved in A. actinomycetemcomitans cell death. These findings demonstrate that DAS exhibits significant antibacterial activity against A. actinomycetemcomitans and

  10. Finanzierung des Studiums

    NASA Astrophysics Data System (ADS)

    Domnick, Ivonne

    "Das liebe Geld“ - ein Thema, das Sie durch das ganze Studium begleitet und auch in der Examensphase und bei der späteren Berufswahl eine entscheidende Rolle spielen wird. Naturwissenschaftler und Ingenieure haben auf dem Arbeitsmarkt sicher derzeit die Nase vorn und brauchen sich über ihre berufliche Zukunft nicht so große Gedanken machen. Doch vor der Karriere muss zunächst einmal eine sichere Studienfinanzierung auf die Beine gestellt werden.

  11. Studies on the Immunochemical Techniques for Detection of Selected Fungal and Dinoflagellate Toxins.

    DTIC Science & Technology

    1985-08-15

    ii)j-ethods for the production of antibodies in rabbits against diacetoxyscirpenol::DAS), deoxyverrucarol (DOVE), acetyl- deoxynivalenol (Ac-DON) and T...diacetoxyscirpenol (DAS), deoxyverrucarol (DOVE), acetyl- deoxynivalenol (Ac-DON) and T-2 toxin metabolites including 3’-OH-T-2, HT-2, and T-2 tetraol tetra-acetate...T-2 tetraol tetra-acetate, DAS, deoxyverrucarol (DOVE), acetyl- deoxynivalenol (DON), and saxitoxin. Properties of such antibodies were investigated

  12. Data acquisition system time measurement capabilities using WorkBench[trademark] software

    SciTech Connect

    Coutts, D.A.

    1992-04-01

    There is an increasing interest in the ability to measure transient behavior in the Heat Transfer Laboratory (HTL). To accomplish this the timing system behavior for the Data Acquisition Systems (DAS) must be evaluated. This report discusses the evaluation of a DAS timing system using WorkBench[trademark] Software in a Macintosh II environment. It also describes a method which can be successfully used to calibrate the timing system associated with the DAS.

  13. Data acquisition system time measurement capabilities using WorkBench{trademark} software

    SciTech Connect

    Coutts, D.A.

    1992-04-01

    There is an increasing interest in the ability to measure transient behavior in the Heat Transfer Laboratory (HTL). To accomplish this the timing system behavior for the Data Acquisition Systems (DAS) must be evaluated. This report discusses the evaluation of a DAS timing system using WorkBench{trademark} Software in a Macintosh II environment. It also describes a method which can be successfully used to calibrate the timing system associated with the DAS.

  14. In Vitro Efficacy of Diallyl Sulfides against the Periodontopathogen Aggregatibacter actinomycetemcomitans

    PubMed Central

    Ganeshnarayan, Krishnaraj; Velusamy, Senthil Kumar; Fine, Daniel H.

    2012-01-01

    The in vitro antibacterial effects of diallyl sulfide (DAS) against the Gram-negative periodontopathogen Aggregatibacter actinomycetemcomitans, the key etiologic agent of the severe form of localized aggressive periodontitis and other nonoral infections, were studied. A. actinomycetemcomitans was treated with garlic extract, allicin, or DAS, and the anti-A. actinomycetemcomitans effects of the treatment were evaluated. Garlic extract, allicin, and DAS significantly inhibited the growth of A. actinomycetemcomitans (greater than 3 log; P < 0.01) compared to control cells. Heat inactivation of the garlic extracts significantly reduced the protein concentration; however, the antimicrobial effect was retained. Purified proteins from garlic extract did not exhibit antimicrobial activity. Allicin lost all its antimicrobial effect when it was subjected to heat treatment, whereas DAS demonstrated an antimicrobial effect similar to that of the garlic extract, suggesting that the antimicrobial activity of garlic extract is mainly due to DAS. An A. actinomycetemcomitans biofilm-killing assay performed with DAS showed a significant reduction in biofilm cell numbers, as evidenced by both confocal microscopy and culture. Scanning electron microscopy (SEM) analysis of DAS-treated A. actinomycetemcomitans biofilms showed alterations of colony architecture indicating severe stress. Flow cytometry analysis of OBA9 cells did not demonstrate apoptosis or cell cycle arrest at therapeutic concentrations of DAS (0.01 and 0.1 μg/ml). DAS-treated A. actinomycetemcomitans cells demonstrated complete inhibition of glutathione (GSH) S-transferase (GST) activity. However, OBA9 cells, when exposed to DAS at similar concentrations, showed no significant differences in GST activity, suggesting that DAS-induced GST inhibition might be involved in A. actinomycetemcomitans cell death. These findings demonstrate that DAS exhibits significant antibacterial activity against A. actinomycetemcomitans and

  15. [Epidemiology of nosocomial infections in a neonatal intensive care unit].

    PubMed

    García, Heladia; Martínez-Muñoz, Angeles Nahima; Peregrino-Bejarano, Leoncio

    2014-01-01

    INTRODUCCIÓN: el recién nacido hospitalizado en una unidad de cuidados intensivos tiene alto riesgo de desarrollar una infección nosocomial. El objetivo de este estudio fue registrar la incidencia y el tipo de infecciones nosocomiales, los microorganismos aislados y el perfil de susceptibilidad de estos en recién nacidos atendidos en una unidad de cuidados intensivos neonatales. MÉTODOS: se llevó a cabo un estudio descriptivo prospectivo longitudinal durante un año. De 113 recién nacidos que presentaron infección nosocomial, se registraron variables demográficas, uso de antibióticos antes del ingreso y de catéter venoso central, tipo de infección, microorganismo aislado y perfil de susceptibilidad.

  16. [Serum lactate as a biomarker of severe sepsis in children with cancer, neutropenia and fever].

    PubMed

    Pacheco-Rosas, Daniel Octavio; Huelgas-Plaza, Ana Celia; Miranda-Novales, María Guadalupe

    2014-01-01

    INTRODUCCIÓN: la neutropenia es una complicación frecuente secundaria a la quimioterapia en los pacientes con cáncer, en quienes la prevalencia de sepsis es de 12.9 a 17.4 % y la letalidad es de 16 %. El objetivo de este estudio fue determinar la utilidad del lactato como biomarcador de sepsis grave en niños con cáncer, fiebre y neutropenia. MÉTODOS: se realizó un estudio de prueba diagnóstica fase II. Se midieron los niveles del lactato al ingreso. Los episodios de neutropenia se clasificaron en tres grupos: I, con sepsis II, sin sepsis; III, pacientes neutropénicos sin fiebre (controles). Se calculó sensibilidad, especificidad, valores predictivos positivo y negativo e índices de verosimilitud. El estándar de oro fue el diagnóstico clínico de sepsis grave.

  17. Streptomyces tritolerans sp. nov., a novel actinomycete isolated from soil in Karnataka, India.

    PubMed

    Syed, Dastager G; Agasar, Dayanand; Kim, Chang-Jin; Li, Wen-Jun; Lee, Jae-Chan; Park, Dong-Jin; Xu, Li-Hua; Tian, Xin-Peng; Jiang, Cheng-Lin

    2007-11-01

    A Gram-positive, nonmotile, moderately halophilic, alkali and thermotolerant strain designated DAS 165(T), was isolated from a dry land soil sample from the Gulbarga region, Karnataka province, India. The isolate produced yellow substrate mycelia and gray aerial mycelia on most tested media. Strain DAS 165(T) showed growth in the presence of 5 to 7% NaCl and at 45 degrees C. The DNA G + C content was 69.7%. 16S rRNA gene sequence analysis together with these characteristics consistently assigned strain DAS 165(T) to the genus Streptomyces. The 16S rRNA gene sequence analysis revealed that strain DAS 165(T) was most closely related to S. tendae ATCC 19812(T) (D 63873) with a sequence similarity of 99.6% (three nucleotide differences out of 1,517). Strain DAS 165(T) formed a distinct clade based on analysis of the almost complete sequence and 120-nucleotide variable gamma region of the 16S rRNA gene. Despite the high sequence similarity, strain DAS 165(T) was phenotypically different from S. tendae ATCC 19812(T). DNA-DNA hybridization between these strains was 47% showing that strain DAS 165(T) is a distinct genomic species. Phenetic and genetic results support the classification of strain DAS 165(T) as a new species, for which the name S. tritolerans is proposed, with strain DAS 165(T) as the type strain (=DSM 41899(T )= CCTCCAA 206013(T)).

  18. Stress-oriented driver assistance system for electric vehicles.

    PubMed

    Athanasiou, Georgia; Tsotoulidis, Savvas; Mitronikas, Epaminondas; Lymberopoulos, Dimitrios

    2014-01-01

    Stress is physiological and physical reaction that appears in highly demanding situations and affects human's perception and reaction capability. Occurrence of stress events within highly dynamic road environment could lead to life-threatening situation. With the perspective of safety and comfort driving provision to anxious drivers, in this paper a stress-oriented Driver Assistance System (DAS) is proposed. The DAS deployed on Electric Vehicle. This novel DAS customizes driving command signal in respect to road context, when stress is detected. The effectiveness of this novel DAS is verified by simulation in MATLAB/SIMULINK environment.

  19. Konventionelle Dampfkraftwerke

    NASA Astrophysics Data System (ADS)

    Zahoransky, Richard; Allelein, Hans-Josef; Bollin, Elmar; Oehler, Helmut; Schelling, Udo

    Das Dampfkraftwerk beruht als thermisches Kraftwerk auf einem thermodynamischen Kreisprozess, der Wärme in technische Arbeit umwandelt. Die Arbeit wird mittels Elektrogenerator als elektrische Energie abgegeben.

  20. Dietary aluminosilicate supplement enhances immune activity in mice and reinforces clearance of porcine circovirus type 2 in experimentally infected pigs.

    PubMed

    Jung, Bock-Gie; Toan, Nguyen Tat; Cho, Sun-Ju; Ko, Jae-hyung; Jung, Yeon-Kwon; Lee, Bong-Joo

    2010-07-14

    Aluminosilicate is the major component of clay minerals such as zeolite, bentonite and clinoptilolite. The minerals possess a number of beneficial activities, especially in regulating the immune system. The aims of the present study were to evaluate immune enhancing effects of dietary aluminosilicate supplement (DAS) in mice, and to demonstrate clearance effects of DAS against porcine circovirus type 2 (PCV2) in experimentally infected pigs as an initial step towards the development of an antibiotic substitute for use in pigs. Relative messenger RNA expression levels of interferon-gamma, interleukin-4 and tumor necrosis factor-alpha, phagocytic activities of polymorphonuclear leucocytes, serum antibody production level and spleen B cell ratio were significantly increased in the DAS groups of mice compared with the control group (each feeding group had three replications with 5 mice each). The results indicated that general immune activity including cellular and humoral immunity could be enhanced by DAS in mice. In experimentally PCV2-infected pigs, the load of viral genome in nasal swab, serum and lung of the DAS group of pigs was significantly decreased compared with the control group at 28 days post-infection (each group three pigs). Corresponding histopathological analyses demonstrated that pigs in the DAS group displayed mild and less severe abnormal changes compared with the control group, indicating that DAS reinforces clearance of PCV2 in experimentally infected pigs. This may relate to general immune enhancing effects of DAS in mice. Therefore DAS will help the health of animal, especially in swine.

  1. 77 FR 63417 - Senior Executive Service; Legal Division Performance Review Board Members

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... and Finance); George Bostick, Benefits Tax Counsel; Bill Bradley, Chief Counsel, Financial Crimes Enforcement Network; Himamauli Das, Assistant General Counsel (International Affairs); Margaret Depue,...

  2. [Late primary abdominal pregnancy. Case report].

    PubMed

    Farías, Emigdio Torres; Gómez, Luis Guillermo Torres; Allegre, René Márquez; Higareda, Salvador Hernández

    2008-09-01

    Abdominal advanced pregnancy is an obstetric complication that put at risk maternal and fetal life. We report a case of advanced abdominal pregnancy with intact ovaries and fallopian tubes, without ureteroperitoneal fistulae and, late prenatal diagnosis, in a multiparous patient without risk factors, with alive newborn, and whose pregnancy was attended at Unidad Medica de Alta Especialidad, Hospital de Gineco-Obstetricia, Centro Medico Nacional de Occidente del IMSS, Guadalajara, Jalisco, México.

  3. Physical, Chemical and Biological Data, CLIMAX I Expedition, 19 September-28 September 1968.

    DTIC Science & Technology

    1974-09-01

    Mr. D. L. Alverson, Base Dir. Buenos Aires, Argentina Northwest Fisheries Center Dr. Donn S. Gorsline National Marine Fisheries Biblioteca Department...Villa Obregon, D. F., San Francisco, Calif. 94118 Pacific Missile Range Mexico Point Mugu, Calif. 93041 University of California Biblioteca Serials...Street Dr. Yuan-Hui Li Durban, Natal, South Africa Biblioteca Hoffman Laboratory Unidad de Ciencias Marinas Harvard University Library, Research

  4. The Spanish National Reference Database for Ionizing Radiations (BANDRRI)

    PubMed

    Los Arcos JM; Bailador; Gonzalez; Gonzalez; Gorostiza; Ortiz; Sanchez; Shaw; Williart

    2000-03-01

    The Spanish National Reference Database for Ionizing Radiations (BANDRRI) is being implemented by a reasearch team in the frame of a joint project between CIEMAT (Unidad de Metrologia de Radiaciones Ionizantes and Direccion de Informatica) and the Universidad Nacional de Educacion a Distancia (UNED, Departamento de Mecanica y Departamento de Fisica de Materiales). This paper presents the main objectives of BANDRRI, its dynamic and relational data base structure, interactive Web accessibility and its main radionuclide-related contents at this moment.

  5. The Military Leaders Survey: NATO Military Leaders’ Perspectives on Psychological Support on Operations

    DTIC Science & Technology

    2006-04-01

    France. E-mail: phil.arvers@free.fr Capt Psy José Puente Inspección General de Sanidad-Unidad de Psicologia [Joint Medical Office-Unit of...health professionals ( social workers, psychiatric nurses, psychologists), chaplains, and medical professionals. Many nations also mentioned relying on...homecoming procedure.” Along the same lines, another respondent noted it would be good “…to have psychologists present at a social event 3 months after

  6. [The cord blood bank at the Instituto Mexicano del Seguro Social].

    PubMed

    Peñaflor-Juárez, Karina; Guillén-Chan, Sonia Marilyn; Romero-Juárez, Yanín; Luna-Bautista, Fernando; Franco-Gutiérrez, Elizabeth; Arellano-Ocampo, Jesús Salvador; Ibáñez-Sánchez, Rocío; de Lourdes Domínguez-Contreras, María; Guerra-Márquez, Angel

    2015-01-01

    Introducción: las células troncales hematopoyéticas se han empleado por más de 50 años en el tratamiento de diversas enfermedades. La sangre de cordón umbilical es una fuente viable de células troncales hematopoyéticas con fines de trasplante. El objetivo es informar la aportación clínica del banco de células de cordón umbilical (BCCU) en el tratamiento de diversas enfermedades.Métodos: desde 2005 a la fecha se analizó el número de unidades de sangre de cordón umbilical (SCU) y su empleo para el trasplante en diversas enfermedades. Se seleccionaron donadoras embarazadas voluntarias en trabajo de parto de quienes se recolectó SCU, la cual fue sometida a su procesamiento, criopreservación y validación, así como a estudios de compatibilidad previo a su uso para trasplante.Resultados: se evaluaron 10 099 candidatas a donación, de quienes se recolectaron 2481 unidades de SCU, de estas se procesaron y criopreservaron 893 unidades para trasplante. En 65 % de los casos hubo histocompatibilidad entre las células de cordón y el receptor. Se trasplantaron 87 pacientes (67 % neoplasias hematológicas), que recibieron 140 unidades SCU en 102 trasplantes.Conclusiones: nuestro Banco de CCU ha logrado desarrollar una línea celular (troncales hematopoyéticas) con estándares de calidad internacionales, y ha beneficiado a pacientes con necesidad de un trasplante, en especial los padecimientos oncohematológicos.

  7. [Diagnostic validity of ultrasonography in carpal tunnel syndrome].

    PubMed

    Bueno-Gracia, Elena; Haddad-Garay, María; Tricas-Moreno, José M; Fanlo-Mazas, Pablo; Malo-Urries, Miguel; Estebanez-de-Miguel, Elena; Hidalgo-Garcia, César; Ruiz de Escudero-Zapico, Alazne

    2015-07-01

    Introduccion. La ecografia ha emergido como una herramienta diagnostica alternativa de las neuropatias perifericas, como el sindrome del tunel carpiano (STC). Sin embargo, faltan datos sobre la validez diagnostica de las diferentes mediciones ecograficas para la deteccion del STC en entornos clinicos. Objetivo. Hallar la validez diagnostica de las mediciones ecograficas del area de seccion transversal del nervio mediano en la muñeca (AST-M) y de la ratio del area del nervio mediano entre la muñeca y el antebrazo (R-MA) en el diagnostico del STC, utilizando como tecnica de referencia el electroneurograma (ENG). Pacientes y metodos. Se realizaron mediciones ecograficas en 59 sujetos (97 muñecas) referidos para someterse a un ENG por sospecha de STC. Los examinadores que realizaron la ecografia desconocian los resultados del ENG. Posteriormente, se calcularon los puntos de corte mediante curvas ROC para cada una de las mediciones (AST-M y R-MA) y se analizo su validez diagnostica. Resultados. Con un punto de corte de 9,15 mm2, la medicion AST-M obtuvo una sensibilidad del 75,81%, una especificidad del 74,29%, una ratio de probabilidad positiva de 2,95 y una ratio de probabilidad negativa de 0,33. Para la medicion R-MA y un punto de corte de 1,56, los valores de sensibilidad, especificidad y ratios de probabilidad positiva y negativa fueron 70,97%, 71,43%, 2,48 y 0,4, respectivamente. Conclusion. Tanto el AST-M como la R-MA parecen ser medidas utiles en el diagnostico del STC tomando como prueba de referencia el ENG.

  8. Prevalencia y tamizaje del Trastorno por Déficit de Atención con Hiperactividad en Costa Rica

    PubMed Central

    Weiss, Nicholas T.; Schuler, Jovita; Monge, Silvia; McGough, James J.; Chavira, Denise; Bagnarello, Monica; Herrera, Luis Diego; Mathews, Carol A.

    2015-01-01

    Resumen La investigación tuvo como propósito estimar la prevalencia del Trastorno por Déficit de Atención con Hiperactividad (TDAH) en Costa Rica y determinar si la versión en español del cuestionario Swanson Nolan and Pelham Scale IV (SNAP-IV) es un instrumento de tamizaje útil en una población de niños y niñas escolares costarricenses. El instrumento fue entregado a padres y maestros de 425 niños entre 5 y 13 años de edad (promedio = 8.8). Todos fueron evaluados con el instrumento Swanson, Kotkin, Agler, M-Flynn and Pelham Scale (SKAMP). Su diagnóstico fue confirmado con una entrevista clínica. La sensibilidad y la especificidad del SNAP-IV fueron evaluadas como predictores de criterios de diagnóstico según el DSM-IV. La prevalencia puntual en la muestra del TDAH fue del 5%. El tamizaje más preciso lo hizo el SNAP-IV completado por el maestro en un corte de 20%, con una sensibilidad de 96% y una especificidad de un 82%. La sensibilidad de los instrumentos completados por los padres fue más baja que aquella de los maestros. El SNAP-IV completado por las maestras con un corte aislando el 20% de los mayores puntajes categorizó correctamente a un 87% de los sujetos. PMID:22432094

  9. [The lymph nodes imprint for the diagnosis of lymphoid neoplasms].

    PubMed

    Peniche-Alvarado, Carolina; Ramos-Peñafiel, Christian Omar; Martínez-Murillo, Carlos; Romero-Guadarrama, Mónica; Olarte-Carrillo, Irma; Rozen-Fuller, Etta; Martínez-Tovar, Adolfo; Collazo-Jaloma, Juan; Mendoza-García, Carlos Alberto

    2013-01-01

    Introducción: los linfomas son las neoplasias linfoproliferativas más frecuentes en México. Su diagnóstico se basa en el estudio histopatológico. El análisis morfológico de la impronta del ganglio linfático se ha utilizado desde hace más de 40 años. Los objetivos de esta investigación fueron determinar la sensibilidad, la especificidad y los valores predictivos positivo y negativo de la impronta del ganglio linfático para el diagnóstico del linfoma y estimar el índice interobservador. Métodos: estudio retrospectivo, observacional y prolectivo de las improntas de ganglios linfáticos obtenidas por biopsia durante un periodo de seis años. Resultados: se incluyeron 199 improntas; 27.1 % se consideró reactivo (n = 54), 16.1 % como linfoma Hodgkin (n = 32), 40.2 % (n = 80) como no Hodgkin y 16.6 % (n = 33) como carcinoma metastásico. Al compararlas con los reportes histopatológicos finales, la sensibilidad fue de 88 % (0.81-0.95), la especificidad de 64 % (0.55-0.73), el valor predictivo positivo de 67 % (0.59-0.76) y el negativo, de 86 % (0.79-0.94). La concordancia interobservador fue moderada (índice kappa de 0.467). Conclusiones: el análisis de la impronta del ganglio linfático es útil para el diagnóstico de las neoplasias linfoproliferativas.

  10. [Peripheral vertigo versus central vertigo. Application of the HINTS protocol].

    PubMed

    Batuecas-Caletrío, Ángel; Yáñez-González, Raquel; Sánchez-Blanco, Carmen; González-Sánchez, Enrique; Benito, José; Gómez, José Carlos; Santa Cruz-Ruiz, Santiago

    2014-10-16

    Introduccion. Uno de los dilemas mas importantes concernientes al vertigo en urgencias es su diagnostico diferencial. Existen signos de alarma de gran sensibilidad en la exploracion que pueden ponernos en la pista de encontrarnos ante un vertigo central. Objetivo. Determinar la eficacia de la aplicacion del protocolo HINTS en el diagnostico del accidente cerebrovascular que simula un vertigo periferico. Pacientes y metodos. Estudio observacional descriptivo sobre pacientes ingresados con diagnostico de sindrome vestibular agudo en urgencias. Todos los pacientes fueron objeto de un seguimiento diario hasta la mejoria de sus sintomas con informacion del nistagmo, la maniobra de impulso oculocefalico y el test de skew. Se comparan los resultados del estudio de resonancia magnetica con la alteracion en alguno de esos tres signos a lo largo del ingreso del enfermo. Resultados. Se reunio a 91 pacientes, con una edad media de 55,8 años. Se objetivo un accidente cerebrovascular en ocho de ellos. De estos (edad media: 71 años), en siete existia una alteracion en alguno de los signos HINTS y en uno el estudio fue normal (sensibilidad: 0,88; especificidad: 0,96). Todos ellos tenian algun factor de riesgo vascular. Conclusiones. Una exploracion adecuada y dirigida ante un paciente que acude a urgencias con un sindrome vestibular agudo resulta de vital importancia para establecer el diagnostico diferencial entre la patologia periferica y la central, ya que algunos accidentes cerebrovasculares se pueden presentar bajo la apariencia de un vertigo agudo. Aplicar un protocolo como HINTS permite sospechar la patologia central con una gran sensibilidad y especificidad.

  11. Evaluacion de los recursos potenciales del petroleo y gas, en Centro y Suramerica [Evaluation of potential petroleum and gas resources in Central and South America

    USGS Publications Warehouse

    Schenk, C.S.

    2001-01-01

    El Servicio Geológico de los Estados Unidos (USGS, por sus siglas en inglés) completó recientemente un estudio evaluativo de recursos potenciales de petróleo y gas en 130 provincias de petróleo seleccionadas en diferentes partes del mundo (USGS, 2000). De estas 130 provincias, 23 se encuentran en Suramérica, Centroamérica, y la región del Caribe (fig. 1). El estudio comprendió desde las provincias de petróleo establecidas con un largo historial de producción, como la Cuenca de Maracaibo, hasta las provincias fronterizas de poca o ninguna producción, como la Cuenca de Guyana-Suriname. No todas las provincias con historial de producción o con potencial de producción fueron evaluadas en el Estudio Evaluativo USGS 2000. Al presente, el USGS está evaluando muchas de las provincias restantes de petróleo y gas, en Centro y Suramérica. En cada provincia hemos (1) definido geológicamente el total de los sistemas de petróleo, (2) definido las unidades evaluadas que forman parte de todos los sistemas de petróleo, y (3) evaluado el volumen potencial de petróleo y gas convencional en cada unidad evaluada. Definimos un total de 26 sistemas de petróleo y 55 unidades evaluadas en las 23 provincias

  12. PubMed

    Antomás Osés, J; Gárriz Murillo, C; Huarte Del Barrio, S; Cambra Contín, K; Ibáñez Beroiz, B

    2016-12-30

    Fundamento. El objetivo de este estudio es estimar la prevalencia de insomnio en pacientes que precisaron ingresar en unidades psiquiátricas hospitalarias de corta estancia.Metodología. Se diseñó un estudio observacional descriptivo en el que tomaron parte 16 unidades de hospitalización psiquiátrica breve de adultos de España. El instrumento utilizado fue la Escala Atenas de Insomnio.Resultados. Se reclutó a 425 pacientes, obtuvieron un valor medio de la puntuación global de la Escala Atenas de Insomnio de 8,56 (DE: 5,78). El ítem para el que se obtuvo mayor puntuación media fue el relativo a la presencia de despertares durante la noche, seguido del relativo al tiempo que lleva quedarse dormido. La prevalencia de insomnio estimada es del 53% (IC 95%).Conclusiones. El insomnio es un problema de elevada prevalencia en las unidades de hospitalización psiquiátricas. Las mayores dificultades se dan en la inducción y el mantenimiento del sueño.

  13. Exploring a new ultrasound score as a clinical predictive tool in patients with rheumatoid arthritis starting abatacept: results from the APPRAISE study

    PubMed Central

    D'Agostino, Maria-Antonietta; Boers, Maarten; Wakefield, Richard J; Berner Hammer, Hilde; Vittecoq, Olivier; Filippou, Georgios; Balint, Peter; Möller, Ingrid; Iagnocco, Annamaria; Naredo, Esperanza; Østergaard, Mikkel; Gaillez, Corine; Le Bars, Manuela

    2016-01-01

    Objectives To explore whether changes in a composite (power Doppler/greyscale ultrasound (PDUS)) synovitis score, developed by the OMERACT-EULAR-Ultrasound Task Force, predict disease activity outcomes in rheumatoid arthritis (RA). Methods Patients with RA who were methotrexate inadequate responders starting abatacept were evaluated. Individual joint PDUS scores were combined in the Global OMERACT-EULAR Synovitis Score (GLOESS) for metacarpophalangeal joints (MCPs) 2–5, all joints (22 paired) and a reduced (9 paired) joint set. The predictive value of changes in GLOESS at week 1–16 evaluations for clinical status and response (Disease Activity Score (DAS)28 (C reactive protein, CRP) <2.6; DAS28(CRP) ≤3.2; DAS28(CRP) ≥1.2 improvement) up to week 24, and correlations between DAS28 and GLOESS were assessed. Results Eighty-nine patients completed the 24-week treatment period. Changes in GLOESS (MCPs 2–5) from weeks 1 to 16 were unable to predict DAS28 outcomes up to week 24. However, significant improvements in GLOESS (MCPs 2–5) were observed at week 12 in patients with DAS28 ≥1.2 improvement at week 24 versus those who did not achieve that clinical response. In patients achieving DAS28 ≥1.2 improvement or DAS28 ≤3.2 at week 24, changes in GLOESS (22 and 9 paired joint sets) were greater in patients who already achieved DAS28 ≥1.2 at week 12 than in those who did not. No significant correlations were found between changes in DAS28 and GLOESS definitions at any time point. Conclusions PDUS was not correlated with clinical status or response as measured by DAS28-derived criteria, and PDUS changes were not predictive of clinical outcome. The discrepancies require further exploration. Trial registration number NCT00767325; Results. PMID:27175297

  14. [Quantitative analysis of drug expenditures variability in dermatology units].

    PubMed

    Moreno-Ramírez, David; Ferrándiz, Lara; Ramírez-Soto, Gabriel; Muñoyerro, M Dolores

    2013-01-01

    Introducción: La existencia de variabilidad en el gasto farmacéutico ajustado entre unidades asistenciales plantea la posibilidad de dificultades en el acceso a determinadas opciones terapéuticas, así como un posible gasto farmacéutico evitable. Sin embargo, los análisis de variabilidad de la práctica clínica no incorporan en general el gasto farmacéutico como medida de resultado. Objetivo: Identificar y cuantificar la variabilidad en cuanto al gasto farmacéutico de unidades de Dermatología comparables del Servicio Andaluz de Salud. Métodos: Análisis comparativo del gasto farmacéutico de 18 unidades de Dermatología del Servicio Andaluz de Salud, ajustado a población y producción asistencial. Los datos sobre resultados de contabilidad y producción asistencial (unidades de producción homogénea -UPH-) fueron proporcionadas por Inforcoan, sistema de información de contabilidad analítica del Servicio Andaluz de Salud. Resultados: La ratio de gasto farmacéutico observada fue de 0,97 ?/hab-8,90 ?/hab y de 208,45 ?/UPH-1.471,95 ?/UPH. El coeficiente de correlación de Pearson entre el gasto farmacéutico y la población fue de 0,25 y de 0,35 para el gasto farmacéutico y la producción homogénea (p=0,32 y p=0,15) respectivamente, ambos indicando la ausencia de correlación y existencia de variabilidad. Conclusión: El análisis cuantitativo de variabilidad realizado mediante correlación de Pearson ha permitido confirmar y cuantificar la variabilidad existente en cuanto al gasto farmacéutico en unidades de Dermatología comparables.

  15. El rol de Ia colaboracion y el Modelo de Aprendizaje Basado en Proyectos (ABPr) mediante el lente de la Teoria de Actividad (CHAT): un estudio de caso con estudiantes de 9no grado

    NASA Astrophysics Data System (ADS)

    Delgado, Isabel C.

    Los modelos de eensenanza y aprendizaje constructivistas conceptualizan el aprendizaje como un proceso activo. El modelo de Aprendizaje Basado en Proyectos (ABPr) se distingue por una serie de componentes, entre los cuales se destaca el aspecto colaborativo y cooperativo como un reto al momento de su implantacion. Son pocas las investigaciones que se concentran en este aspecto del modelo. En este estudio, se analizaron las diversas interacciones que surgen durante la implantacion de una unidad curricular sobre el tema de Geologia de Puerto Rico, la cual se diseno con el modelo ABPr cuyo enfoque es orientacion a proyectos. Particularmente, se examinaron las interacciones sociales que surgen entre los pares y entre pares y docente durante el proceso de planificacion y desarrollo de los productos finales, al igual que las interacciones entre los estudiantes y el material didactico en estas etapas del modelo. La investigacion es de tipo cualitativo e incorpora como diseno el estudio de caso. Las diversas interacciones constituyen la unidad de analisis. En el estudio participaron 19 estudiantes de 9no grado, a quienes se organizaron en 5 grupos colaborativos por temas de interes (Pangea, Placas tectonicas, Volcanes, Tsunamis y Terremotos). Las tecnicas que se utilizaron para recopilar los datos fueron: observaciones participativas, grupos focales y analisis de documentos (cuadernos reflexivos y respuestas de los estudiantes a la pregunta central del proyecto). Para el analisis de los datos se aplico la teoria de actividad (CHAT) que concentra la unidad de analisis en la actividad humana en un contexto particular. Los resultados del estudio senalan que las interacciones entre pares, entre pares y docente, asi como entre estudiantes y material didactico son fundamentales en el proceso de aprendizaje. Una mayor interaccion entre pares durante las etapas de planificar y desarrollar los productos finales de la unidad, promueve una mejor comprension de los conceptos de la

  16. Rheological characteristics and morphology of dialdehyde starch/meat composites during heating.

    PubMed

    Chiang, P Y; Li, J Y; Chen, M L

    2009-03-01

    Dialdehyde starch (DAS) was added to pork ham batter. The effects of DAS on the meat protein gel during heating were investigated using thermal and rheological analyses. In this study, the degree of DAS oxidation was controlled by the reaction time. The DSC thermogram showed that increasing the degree of oxidation resulted in DAS having a higher gelatinization temperature and lower heat absorption. In dialdehyde starch/meat (DAS/M) composites, meat protein reduced the availability of water to starch and raised the gelatinization temperature and heat absorbed by the composites. The G'(max) of the composites was greater than the linear combination of their components. The rheological properties of DAS were a major factor affecting the properties of its composites. Scanning electron microscopy and light microscopy with the aid of histologic technique revealed the network and distribution of DAS and DAS/M composites. The protein matrix formed the backbone of the network and gelatinized starch was trapped in the protein structure.

  17. Europäisches Organ der Festkörperforschung und DDR-Devisenbringer Die Zeitschrift Physica Status Solidi im Kalten Krieg

    NASA Astrophysics Data System (ADS)

    Hoffmann, Dieter

    Mit dem Ziele, ein einheitliches internationales Organ der Festkörperphysik für den europäischen Raum zu schaffen, das eine rasche Publikation der für das Festkörpergebiet repräsentative Arbeiten ermöglicht, wird durch ein internationales Herausgebergremium eine neue wissenschaftliche Zeitschrift gegründet.

  18. 75 FR 4381 - Pesticide Experimental Use Permit; Receipt of Amendment and Extension Application; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ..., (29964-EUP- 6). Pesticide Chemicals: Bacillus thuringiensis Cry1F protein and the genetic material... and Development (OECD) Unique Identifier: DAS-01507-1), Bacillus thuringiensis Cry34Ab1 and Cry35Ab1...-7 (OECD Unique Identifier: DAS-59122-7), Bacillus thuringiensis Cry1Ab delta-endotoxin protein...

  19. 77 FR 26512 - Proposed Information Collection; Comment Request; Northeast Multispecies Days-at-Sea Leasing Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... Multispecies Days-at-Sea Leasing Program AGENCY: National Oceanic and Atmospheric Administration (NOAA... (DAS) leasing requirements at Sec. 648.82(k) form the basis for this collection of information. The NE Multispecies DAS leasing program was implemented in 2004 as a result of Amendment 13 (69 FR 22906)...

  20. 78 FR 34653 - Proposed Information Collection; Comment Request; Northeast Multispecies Days-at-Sea Leasing Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... Multispecies Days-at-Sea Leasing Program AGENCY: National Oceanic and Atmospheric Administration (NOAA... (DAS) leasing requirements at Sec. 648.82(k) form the basis for this collection of information. The NE multispecies DAS leasing program was implemented in 2004 as a result of Amendment 13 (69 FR 22906)...

  1. General Factor Loadings and Specific Effects of the Differential Ability Scales, Second Edition Composites

    ERIC Educational Resources Information Center

    Maynard, Jennifer L.; Floyd, Randy G.; Acklie, Teresa J.; Houston, Lawrence, III

    2011-01-01

    The purpose of this study was to investigate the "g" loadings and specific effects of the core and diagnostic composite scores from the Differential Abilities Scales, Second Edition (DAS-II; Elliott, 2007a). Scores from a subset of the DAS-II standardization sample for ages 3:6 to 17:11 were submitted to principal factor analysis. Four…

  2. The Equilibrium Mixed Layer Depth in the Tropical Atlantic. The Rotation Stress and Penetration of Radiation Effects.

    DTIC Science & Technology

    1985-06-01

    California 93943 7. Capitio tenente Joaquim Gaspar Divisio de Oceanografia Fisica Instituto Hidrogrifico Rua das Trinas, 49 P - 1296 Llsboa CODEX...Portugal 8. Biblloteca Instituto Hidrogrifico Rua das Trinas, 49 P - 1296 Lisboa CODEX Portugal 75 "*.&..- :.._ . :.,. 9. Departamento de Oceanografia ...Lisboa CODEX Portugal 11. Departamento de Oceanografia - Instituto Nacional de M’etereologia e Geofisica Rua C , Airoporto de Lisboa Lisboa Portugal

  3. Reply to "Comment on `Quantum Raychaudhuri equation'"

    NASA Astrophysics Data System (ADS)

    Das, Saurya

    2017-03-01

    The preceding Comment claims that the paper "Quantum Raychaudhuri equation" by S. Das, [Phys. Rev. D 89, 084068 (2014), 10.1103/PhysRevD.89.084068] has "problematic points" with regards to its derivation and implications. We show below that the above claim is incorrect, and that there are no problems with the results of Das's paper or its implications.

  4. Depression and Anxiety Symptoms: Onset, Developmental Course and Risk Factors during Early Childhood

    ERIC Educational Resources Information Center

    Cote, Sylvana M.; Boivin, Michel; Liu, Xuecheng; Nagin, Daniel S.; Zoccolillo, Mark; Tremblay, Richard E.

    2009-01-01

    Background: Depressive and anxiety disorders are among the top ten leading causes of disabilities. We know little, however, about the onset, developmental course and early risk factors for depressive and anxiety symptoms (DAS). Objective: Model the developmental trajectories of DAS during early childhood and to identify risk factors for atypically…

  5. Screening for Aggression Using the Draw a Story Assessment. Brief Report

    ERIC Educational Resources Information Center

    Earwood, Cheryl; Fedorko, Melinda; Holzman, Eileen; Montanari, Linda; Silver, Rawley

    2004-01-01

    The purpose of this study was to find out if the Draw a Story (DAS) assessment can be used as a screening technique to identify children and adolescents at risk for aggression. Four art therapists presented the DAS tasks to 30 students with histories of aggressive behavior and to 181 students with no histories of aggression. After the 211…

  6. Dysfunctional Attitudes and Suicidal Ideation in Psychiatric Outpatients.

    ERIC Educational Resources Information Center

    Beck, Aaron T.; And Others

    1993-01-01

    Administered Dysfunctional Attitude Scale (DAS), Beck Depression Inventory (BDI), Hopelessness Scale (BHS), Self-Concept Test (BST), and Scale for Suicide Ideation (SSI) to 908 psychiatric outpatients. Found that none of DAS subscales discriminated ideators and nonideators or was significantly related to SSI total scores of suicide ideators after…

  7. 75 FR 35435 - Fisheries of the Northeastern United States; Atlantic Deep-Sea Red Crab Fisheries; 2010 Atlantic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-22

    ... catch (TAC) and a fleet-wide days-at-sea (DAS) allocation. However, the implementing regulations for the... rulemaking is to adjust the target TAC and corresponding fleet DAS allocation equivalent to the revised... crab emergency action implemented by NMFS (74 FR 9770, March 6, 2009), i.e., a target TAC of...

  8. Beginn des Studiums

    NASA Astrophysics Data System (ADS)

    Domnick, Ivonne

    Ihr Herz schlägt für die Naturwissenschaften? Die Arbeitsmarktaussichten sind gut. Das Studium einer der vier MINT-Disziplinen ist daher eine gute Investition in die Zukunft. Wie Sie erfolgreich in das Studium starten, erfahren Sie auf den folgenden Seiten.

  9. Multigroup Confirmatory Factor Analysis of U.S. and Italian Children's Performance on the PASS Theory of Intelligence as Measured by the Cognitive Assessment System

    ERIC Educational Resources Information Center

    Naglieri, Jack A.; Taddei, Stefano; Williams, Kevin M.

    2013-01-01

    This study examined Italian and U.S. children's performance on the English and Italian versions, respectively, of the Cognitive Assessment System (CAS; Naglieri & Conway, 2009; Naglieri & Das, 1997), a test based on a neurocognitive theory of intelligence entitled PASS (Planning, Attention, Simultaneous, and Successive; Naglieri & Das,…

  10. Continuing German in Grade Five: MLA Teacher's Guide. A Course of Study Including Methods, Materials, and Aids for Teaching German to Fifth-Grade Pupils.

    ERIC Educational Resources Information Center

    Memming, Agnes K.; And Others

    This teacher's guide, for use in a fifth-grade German course, contains 12 units of instructional materials which concentrate on the development of basic audiolingual skills. Each of the units consists of conversational skits, dialogue adaptation, directed dialogue review, and classroom drills. Units include: (1) Das Aufstehen und das Fruhstuck,…

  11. Tipps und Tricks

    NASA Astrophysics Data System (ADS)

    Häger, Wolfgang; Bauermeister, Dirk

    Hier wollen wir einige uns nützlich erscheinende Hinweise zur Arbeit mit dem Inventor geben. Dabei geht es vor allem darum, das Arbeiten mit dem Inventor zu vereinfachen. Die Beispiele stellen eine unvollständige Aufzählung dar und sollen dazu anregen, nach alternativen Vorgehensweisen zu suchen (hier sei noch einmal ausdrücklich auf das Internet verwiesen).

  12. An Exploratory Analysis of the Potential Association Between SCI Secondary Health Conditions and Daily Activities

    PubMed Central

    Cobb, John; Dumont, Frédéric S.; Leblond, Jean; Park, So Eyun; Noonan, Vanessa K.

    2014-01-01

    Background: Secondary health conditions (SHCs) are common following traumatic spinal cord injury (tSCI) and are believed to influence a person’s ability to participate in daily activities (DAs). This association should be understood so that health care providers may target interventions with clarity and purpose to manage SHCs and facilitate DAs to maximal effect. Objective: To explore the association between SHCs and DAs expressed as the increased chance of not participating as much as wanted in a DA when an SHC is present. Methods: Community-dwelling persons with tSCI (n = 1,137) responded to the SCI Community Survey. The occurrence and frequency of 21 SHCs were determined. The extent of participation in 26 DAs was measured. The relative risk (RR) of not participating as much as wanted in a DA when a SHC is present was calculated. Results: When some SHC were present, the RR of not participating as much as wanted increased significantly (range, 15%-153%; P < .001). Certain SHCs (light-headedness/dizziness, fatigue, weight problems, constipation, shoulder problems) were associated with a greater chance of not participating in many DAs. No single SHC was associated with every DA and conversely not every DA was associated with an SHC. Conclusions: Maximizing participation in DAs requires minimizing SHCs in every instance. Understanding the association between SHCs and DAs may facilitate targeted care resulting in less severe SHCs, greater participation in DAs, and benefits to both the individual and society. PMID:25477741

  13. 76 FR 79612 - Magnuson-Stevens Fishery Conservation and Management Act Provisions; Fisheries of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-22

    .... Comments sent by any other method, to any other address or individual, or received after the end of the... end of the fishing year, if approved, the credited DAS would apply to the year in which the canceled trip occurred. Credited DAS that remain unused at the end of the fishing year or are not credited...

  14. N-succinyl chitosan–dialdehyde starch hybrid hydrogels for biomedical applications

    PubMed Central

    Kamoun, Elbadawy A.

    2015-01-01

    A new class of injectable, biocompatible and biodegradable hydrogel is reported. This hydrogel is derived from N-succinyl chitosan (SCS) mixed with water-soluble dialdehyde starch (DAS) without using a conventional chemical crosslinker. The hybrid hydrogel is formed owing to the Schiff’s base reaction between amine groups of SCS and dialdehyde groups of DAS to form —CH 000000000000 000000000000 000000000000 111111111111 000000000000 111111111111 000000000000 000000000000 000000000000 N— group. SCS, DAS, and SCS–DAS hybrid hydrogels were synthesized and then characterized by FTIR analysis spectroscopy. The influence of SCS:DAS ratio in hybrid polymers solution on physicochemical properties of resultant hydrogels (e.g. gelation time, gel fraction (%) and equilibrium swelling ratio), surface morphology, in vitro weight loss (%), and mechanical stability was examined. The results demonstrated that SCS content has a profound role for forming tighter crosslinked hybrid hydrogels, where the increase of SCS content reduces the time for hydrogel forming. Also, the water uptake and hydrolytic weight loss decrease. Meanwhile, the DAS content increases, and mechanical properties of SCS–DAS hybrid hydrogels decrease. Curcumin release profile and adhered HGF cells on hydrogel surface sharply influenced the SCS portion in hybrid hydrogel composition. The SCS–DAS hybrid hydrogel properties afforded a possible opportunity to be used as a covalent in situ forming hybrid hydrogels in biomedical applications such as, tissue engineering and cartilage repair. PMID:26843972

  15. 75 FR 80720 - Magnuson-Stevens Act Provisions; Fisheries of the Northeastern United States; Northeast...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... preamble, and the Classification sections of the final rule. ] FOR FURTHER INFORMATION CONTACT: Melissa..., sector vessels may still use, and lease, NE multispecies DAS. The Sustainable Harvest Sector and Tri... restrictions on DAS leases between vessels within their individual sectors as well as with vessels in...

  16. 76 FR 56322 - Fisheries of the Northeastern United States; Northeast (NE) Multispecies Fishery; Framework...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... estimated that common pool catch of witch flounder would exceed the common pool sub-annual catch limit (sub... where witch flounder are predominately caught. The differential DAS rate applies to all Category A DAS... witch flounder was only exceeded by 20 percent, and the total ACL for northern windowpane flounder...

  17. Theory in practice instead of theory versus practice--curricular design for task-based learning within a competency oriented curriculum.

    PubMed

    Rotthoff, Thomas; Schneider, Matthias; Ritz-Timme, Stefanie; Windolf, Joachim

    2015-01-01

    Zielsetzung: Medizinstudierende sollen bereits während ihres Studiums ärztliches Denken und Handeln intensiv trainieren und ihre klinische Expertise in theoretischer und praktischer Hinsicht entwickeln. Methodik: Ausgehend von den Erkenntnissen der Lehr- und Lernforschung wurde ein Curriculum für die klinisch-praktische Ausbildung im Modellstudiengang Düsseldorf entwickelt, welches auf das arbeitsplatzbezogene Lehren, Lernen und Prüfen fokussiert. Ergebnisse: Das Curriculum basiert für Studierende im 3, 4 und 5. Studienjahr wesentlich auf dem Lernen an Behandlungsanlässen von Patienten in multidisziplinären Bereichen der ambulanten und stationären Versorgung. Für dieses Lehrformat wurden 123 Behandlungsanlässe definiert und deren Verknüpfbarkeit mit Krankheitsbildern aus den verschiedenen Fachdisziplinen geprüft. Ausgehend vom Behandlungsanlass eines konkreten Falles, erarbeiten sich die Studierenden das zugrundeliegende Krankheitsbild sowie das differentialdiagnostische und therapeutische Vorgehen und vertiefen dabei das notwendige Wissen in den Grundlagenfächern. Zur Lernunterstützung wurden Studienbücher von den Kliniken erstellt. Das Lernen ist eingebunden in kompetenzorientiertes und arbeitsplatzbezogenes Lernen und Prüfen mit einer intensiven Kontaktzeit zwischen Studierenden und Ärzten.Schlussfolgerung: Das Konzept ermöglicht die Integration von Theorie in die Praxis sowie die Integration von Wissen aus den Grundlagen-, klinisch-theoretischen und klinischen Fächern in das ärztliche Denken und Handeln.

  18. Sensitivity Studies Using Multi-Region and Open Boundary Conditions for Terrain Bottom-Following Ocean Models

    DTIC Science & Technology

    2003-03-01

    Vol. 5, No. 1, 31-40, 1982. Fiuza, A. F. de G., Hidrologia e Dinamica das Aguas Costeiras de Portugal. Dissertacao apresentada a Universidade de...Upwelling: Its Sediment Record, part A, pp 85-97, Plenum, New York, 1983. Fiuza, A. F. G., Hidrologia e Dinamica das Aguas Costeiras de Portugal

  19. Synthesis of radiolabeled mycotoxins. Annual report, 1 December 1985-30 November 1986

    SciTech Connect

    Kraus, G.A.

    1987-02-01

    The synthesis of labeled trichothecenes by degradation of diaceotxy scirpenol (DAS) is the subject of this report. The DAS was acetylated and deoxygenated to provide a diene which was selectively oxidized, deuterated, and epoxidized. This enone has been reduced. The remaining steps, separation and acetate removal, are in progress.

  20. Astrowissen. Zahlen - Daten - Fakten.

    NASA Astrophysics Data System (ADS)

    Keller, H.-U.

    This book is a completely revised and enlarged version of the 1994 edition (see Abstr. 61.003.081). Contents: Astronomie - die Wissenschaft vom Universum und seinen Sternen. Astronomische Instrumente. Sphärische Astronomie. Grundzüge der Himmelsmechanik. Das Sonnensystem. Stellarastronomie. Doppelsterne und Veränderliche. Sternhaufen und Assoziationen. Das Milchstraßensystem. Galaxien und Kosmologie. Meilensteine der Astronomie.

  1. 77 FR 42699 - New England Fishery Management Council; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... Director, New England Fishery Management Council; telephone: (978) 465-0492. SUPPLEMENTARY INFORMATION: The... modifications to the current days-at-sea (DAS) management system, including alternatives to enable DAS leasing... National Oceanic and Atmospheric Administration RIN 0648-XC116 New England Fishery Management...

  2. Evaluating the Invariance and Validity of the Structure of Dysfunctional Attitudes in an Adolescent Population

    ERIC Educational Resources Information Center

    Prenoveau, Jason M.; Zinbarg, Richard E.; Craske, Michelle G.; Mineka, Susan; Griffith, James W.; Rose, Raphael D.

    2009-01-01

    Form A of the Dysfunctional Attitude Scale (DAS-A), a self-report measure of depressive beliefs, is widely used to test Beck's cognitive model of depression. The present study is the first to evaluate the DAS-A factor structure in an adolescent population of 542 high school juniors and the first to examine a hierarchical model. Findings support…

  3. Optical Real Time Signal Processors and Semiconductor Surface and Semiconductor-Electrolyte Interface Study Using Acoustic Surface Wave.

    DTIC Science & Technology

    1981-08-01

    Resistivity GaAs", J. Appl. Phys., Vol. 50, pp. 4942-4950, 1979. Copies of the papers are available upon request. 2 5. J . Scott Moore and P. Das, "The...Papers presented with support from the contract 1. J . Scott Moore and P. Das, "Hot Electron Effects in Quasi-Two Dimensional Semiconductors

  4. 48 CFR 833.103 - Protests to VA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... for A&MM. (ii) The Director, Office of Construction and Facilities Management, in the case of a contract awarded by the Office of Construction and Facilities Management. (iii) The Comptroller General. (3.... The contracting officer must submit the case promptly to the DAS for A&MM for advice. The DAS for...

  5. Shared Decision Making and Patient Decision Aids: Knowledge, Attitudes, and Practices Among Hawai‘i Physicians

    PubMed Central

    Friend, John; Chun, Maria BJ

    2013-01-01

    Background: As the health care field moves toward patient-centered care (PCC), increasing emphasis has been placed on the benefits of patient decision aids for promoting shared decision making (SDM). This study provides a baseline measure of knowledge, attitudes, and practices (KAP) among Hawai‘i's physicians with respect to patient decision aids (DAs). Physicians throughout the State of Hawai‘i were invited to complete a survey assessing their knowledge, attitudes, and practices with respect to the clinical use of DAs. One hundred and seventy four valid surveys were analyzed. Reported awareness and use of DAs were low, but recognition of the benefits of SDM and openness to the use of DAs were very high. The leading perceived barriers to the implementation of DAs were lack of awareness, lack of resources, and limited physician time to learn about DA technology. However, a significant majority of the respondents reported that DAs could empower patients by improving knowledge (88%), increasing satisfaction with the consultation process (81%), and increasing compliance (74%). Among physicians currently employing DAs, use of brochures or options matrix sheets was the most common aid tool. However, leading recommended DA formats were paper-based brochures for clinic use (75%) and interactive online website programs for outside clinic use (73.5%). Given growing emphasis on the PCC model and the recognized desire of many patients to participate in the medical decision making process, positive responses toward SDM and the use of DAs by Hawai‘i physicians are promising. PMID:24251086

  6. Potential of Diallyl Sulfide Bearing pH-Sensitive Liposomes in Chemoprevention Against DMBA-Induced Skin Papilloma

    PubMed Central

    Khan, Arif; Shukla, Yogeshwer; Kalra, Neetu; Alam, Maroof; Ahmad, Manzoor Gatoo; Hakim, Seema Rashid; Owais, Mohammad

    2007-01-01

    Diallyl sulfide (DAS), an active component of garlic, possesses strong anti-neoplastic properties against various forms of cancer. In the present study, we have evaluated chemo-preventive effects of liposomized DAS (conventional egg PC and pH-sensitive liposomes) against DMBA-induced skin papilloma. Various liposome-based novel formulations of DAS (250 μg/mouse) were applied topically, after one hour of exposure to DMBA (52 μg/mouse/dose), to the animals. The animals were treated thrice weekly for the total period of 12 weeks. The efficacy of the various liposomal formulations of DAS was evaluated on the basis of parameters such as incidence of tumorogenesis and total numbers and sizes of induced tumor nodules. The liposomized DAS formulations also were assessed for their effect on the expression of p53wt, p53mut, and p21/Waf1. The results of the present study showed that liposomized DAS could effectively delay the onset of tumorogenesis and reduce the cumulative numbers and sizes of tumor papillomas in treated mice. Treatment of DMBA-exposed animals with the liposomal formulation of DAS ensued in upregulation of p53wt and p21/Waf1, while levels of p53mut expression reduced down. The promising chemo-preventive nature of liposomal DAS may form the basis for establishing effective means of controlling various forms of cancer, including skin papilloma. PMID:17622315

  7. SNR characterization in distributed acoustic sensing

    NASA Astrophysics Data System (ADS)

    Gabai, Haniel; Eyal, Avishay

    2016-05-01

    In this paper we study the SNR associated with acoustic detection in Rayleigh-based Distributed Acoustic Sensing (DAS) systems. The study is focused on phase sensitive DAS due to its superiority in terms of linearity and sensitivity. Since DAS is based on coherent interference of backscattered light from multiple scatterers it is prone to signal fading. When left unresolved, the issue of signal fading renders the associated SNR randomly dependent on position and time. Hence, its proper measurement and characterization requires statistical tools. Here such tools are introduced and a methodology for finding the mean SNR and its distribution is implemented in both experiment and simulation. It is shown that the distribution of the DAS-SNR can be obtained from the distribution of backscattered power in OTDR and the mean DAS-SNR is proportional to the energy of the interrogation pulse.

  8. Knowledge and attitudes of dental interns toward denture adhesives in King Saud University, Riyadh, Saudi Arabia

    PubMed Central

    Al Taweel, Sara Mohammad; Al Shehri, Huda Ahmed

    2016-01-01

    Objective: The objective of this study was to evaluate the knowledge and attitudes of dental interns at King Saud University College of Dentistry (KSUCD) regarding denture adhesives (DAs). Materials and Methods: Surveys were distributed to dental interns at KSUCD (n = 100). Cross-tabulations with the Pearson-™s Chi-square test were used to compare variables using the Statistical Package for Social Sciences (P ≤ 0.05). Results: Approximately, 85.5% of the respondents had learned about DAs as part of their undergraduate curriculum, 71% agree that DAs can be a beneficial adjunct in the fabrication of dentures, and 87% agree that dentists should routinely inform all denture patients of the proper use and misuse of DAs. Conclusion: Most of the participants have adequate knowledge and attitude toward DAs. PMID:28042271

  9. Moderating influence of dominant attentional style and exercise intensity on responses to asynchronous music.

    PubMed

    Hutchinson, Jasmin C; Karageorghis, Costas I

    2013-12-01

    We examined independent and combined influences of asynchronous music and dominant attentional style (DAS) on psychological and psychophysical variables during exercise using mixed methods. Participants (N = 34) were grouped according to DAS and completed treadmill runs at three intensities (low, moderate, high) crossed with three music conditions (motivational, oudeterous, no-music control). State attentional focus shifted from dissociative to associative with increasing intensity and was most aligned with DAS during moderate-intensity exercise. Both music conditions facilitated dissociation at low-to-moderate intensities. At high exercise intensity, both music conditions were associated with reduced RPE among participants with an associative DAS. Dissociators reported higher RPE overall during moderate and high intensities. Psychological responses were most positive in the motivational condition, followed by oudeterous and control. Findings illustrate the relevance of individual differences in DAS as well as task intensity and duration when selecting music for exercise.

  10. Ein Organic Computing Ansatz zur Steuerung einer sechsbeinigen Laufmaschine

    NASA Astrophysics Data System (ADS)

    Auf, Adam El Sayed; Larionova, Svetlana; Mösch, Florian; Litza, Marek; Jakimovski, Bojan; Maehle, Erik

    Obwohl die Rechengeschwindigkeit von Computern und die Komplexität unserer Systeme ständig zunimmt, sind die heutigen Laufmaschinen nicht in der Lage, sich mit den Fähigkeiten von Landtieren wie zum Beispiel Insekten zu messen. Das Verständnis biologischer Konzepte und das Lernen von der Natur könnten zur Verbesserung der heutigen Maschinen beitragen und sie ein wenig “lebensähnlicher“ machen. Dieser Artikel stellt einen Kontrollarchitekturansatz basierend auf “Organic Computing“-Prinzipien vor, der die Nutzung von Dezentralisierung und Selbstorganisation an einer sechsbeinigen Laufmaschine demonstriert. Die vorliegende Arbeit erklärt die elementaren Mechanismen für das gerade Laufen, das Kurvenlaufen sowie das Drehen auf der Stelle und den Umgang mit strukturellen körperlichen Änderungen wie einer Beinamputation und stellt die Ergebnisse experimenteller Versuche vor.

  11. A New High Channel-Count, High Scan-Rate, Data Acquisition System for the NASA Langley Transonic Dynamics Tunnel

    NASA Technical Reports Server (NTRS)

    Ivanco, Thomas G.; Sekula, Martin K.; Piatak, David J.; Simmons, Scott A.; Babel, Walter C.; Collins, Jesse G.; Ramey, James M.; Heald, Dean M.

    2016-01-01

    A data acquisition system upgrade project, known as AB-DAS, is underway at the NASA Langley Transonic Dynamics Tunnel. AB-DAS will soon serve as the primary data system and will substantially increase the scan-rate capabilities and analog channel count while maintaining other unique aeroelastic and dynamic test capabilities required of the facility. AB-DAS is configurable, adaptable, and enables buffet and aeroacoustic tests by synchronously scanning all analog channels and recording the high scan-rate time history values for each data quantity. AB-DAS is currently available for use as a stand-alone data system with limited capabilities while development continues. This paper describes AB-DAS, the design methodology, and the current features and capabilities. It also outlines the future work and projected capabilities following completion of the data system upgrade project.

  12. Characterization of red-near infrared transition for wheat and chickpea using 3 nm bandwidth data

    NASA Astrophysics Data System (ADS)

    Gupta, R. K.; Vijayan, D.; Prasad, T. S.

    2001-01-01

    Enhancement of space based capabilities to discriminate different crops and different varieties of a particular crop needs measurement of (i) the shift in red edge and (ii) the slope of the sudden rise of reflectance in 680 - 760 nm spectral region as a function of Days After Sowing (DAS). To develop the knowledge base for catering to the analysis of future space-based hyperspectral measurements, ground based measurements in 3 nm bandwidth in visible - near Infrared region together with corresponding Leaf Area Index (LAI) observations were taken over the Crop Growth Cycle (CGC) of Wheat and Chickpea. The red edge for wheat crop was at 679 nm for 25 DAS and reached the upper limit i.e., 693.7 nm at 84 DAS and thereafter shifted backward to 679 nm at 108 DAS. There was no change in red edge value of 684.9 nm during 40 to 49 DAS and of 687.8 nm during 55 to 71 DAS. The slope of Red to NIR transition for wheat varied from 0.457 to peak value of 0.784 during 25 to 71 DAS and thereafter decreased to 0.073 at 108 DAS. The peak of Red to Near Infrared (NIR) transition slope and Ratio Vegetation Index (RVI) occurred at the same time i.e., 71 DAS. However, the upper most value of red edge shift occurred at 84 DAS. Paper discusses the above aspects including role of mid point of Red to NIR transition, interrelationships among the Red-NIR transition Slope, Red Edge, LAI and RVI for wheat and chickpea.

  13. [Complications of pediatric renal transplantation].

    PubMed

    Gonçalves, Cristina; Sandes, Ana Rita; Azevedo, Sara; Stone, Rosário; Almeida, Margarida

    2013-01-01

    Introdução: A transplantação renal é a terapêutica de eleição na criança com doença renal crónica terminal, evidenciando impacto positivo na sobrevida e qualidade de vida dos doentes. Não é, no entanto, isenta de complicações, algumas com importante morbilidade. Os autores pretendem caracterizar o perfil de complicações pós transplantação renal em doentes pediátricos (até 18 anos).Material e Métodos: Análise retrospectiva dos doentes submetidos a transplantação renal e seguidos na Unidade de Nefrologia Pediátrica entre Setembro de 1995 e Agosto de 2010. Dados obtidos dos processos clínicos: características demográficas, etiologia da doença renal crónica terminal, terapêutica de substituição renal, mortalidade e perda de enxertos, complicações cirúrgicas, infecciosas e não infecciosas (rejeição aguda e crónica, recidiva da doença de base, alterações metabólicas e factores de risco cardiovascular). Análise estatística descritiva simples.Resultados: Foram incluídas 78 crianças transplantadas (48,7% sexo masculino), com idade mediana à data da transplantaçãorenal de 12 anos (2 - 18). A maioria fez previamente diálise peritoneal: 49 (62,6%). Cinco doentes (6,4%) foram transplantados sem diálise prévia. A mediana do tempo de seguimento após transplante foi 37,5 meses (1 - 169). As principais etiologias de doença renal crónica terminal foram: uronefropatias (41%) e glomerulopatias (28,2%). As complicações infecciosas ocorreram em 74,4%; infecçõesvirais em 56,4%, sendo a mais prevalente a infecção citomegalovírus (39,7%); infecções bacterianas em 53,8% (na maioria infecções urinárias em doentes urológicos). Outras complicações: 1) factores de risco para doença cardiovascular: hipertensão arterial em 85,9%; dislipidémia em 16,7% e diabetes de novo em 7,7%; 2) episódios de rejeição aguda em 32,1% e nefropatia crónica do enxerto em 17,9%; 3) complicações relacionáveis com a cirurgia em 16

  14. Bagless Transfer System Welder Data Acquisition Software

    SciTech Connect

    Collins, Susan L.

    2003-09-30

    The Bagless Transfer System Welder Data Acquisition Software (BTS DAS) was developed by SRTC to replace a strip chart recorder that has been in place since the design of the BTS. During the welding process, critical weld parameters such as weld current and voltage, can give valuable information about the weld. In the past, weld data from the TID welding process, has been monitored using strip chart recorders. The data from the weld process, recorded on the strip chart recorder traces, are reviewed to analyze the weld. The BTS DAS improves this technology by digitizing the weld data which allows for automation of the analysis process. Also, the data files are now stored digitally as well as a hard copy printout, so they can be reanalyzed if needed. The BTS DAS performs the necessary functions to perform the data acquisition functions during the BTS Welding Process. It is important to monitor the critical weld parameters, current and voltage, during a weld as they can be used to set acceptance criteria for weld acceptance. The software monitors and records the weld current, voltage, and RPM data. The welder DAS is a passive device and does not control the welder. The BTS control system interfaces directly with the welder and the BTS DAS. Digital handshaking is used between the BTS DAS and the BTS control system to ensure that the DAS is ready to weld prior to allowing the operator to initiate the welding process.

  15. Diallyl sulfide inhibits diethylstilbesterol-induced DNA adducts in the breast of female ACI rats.

    PubMed

    Green, M; Wilson, C; Newell, O; Sadrud-Din, S; Thomas, R

    2005-09-01

    Diethylstilbestrol (DES) is metabolized to reactive intermediates that produce DNA adducts and ultimately cancer. Diallyl sulfide (DAS) has been shown to inhibit the metabolism of several procarcinogens. The ability of DES to produce DNA adducts in microsomal, mitochondrial, and nuclear in vitro metabolic systems and in the breast of female ACI rats, as well as ability of DAS to inhibit DNA adducts were investigated. Microsomes, mitochondria, and nuclei isolated from breast tissue of female ACI rats were used to catalyze oxidation reactions. Female ACI rats were treated i.p. as follows: (1) corn oil, (2) 200mg/kg DES, (3) 200mg/kg DES/200mg/kg of DAS, (4) 200mg/kg DES/400mg/kg DAS. DES produced DNA adducts in each metabolic system. The relative adduct levels were 2.1 x 10(-4), 6.2 x 10(-6), and 2.9 x 10(-7) in microsomal, mitochondrial, and nuclear reactions, respectively. DAS inhibited DNA adducts in each metabolic system. The percent inhibition ranged from 86% in microsomes to 93% in nuclei. DES produced DNA adducts in mtDNA and nDNA. DAS completely inhibited the DES-induced mtDNA adducts and caused a dose dependent decrease in nDNA adduct formation. These findings suggest that DAS could inhibit DES-induced breast cancer by inhibiting its metabolism.

  16. Medical Students' Perceptions of Dementia after Participation in Poetry Workshop with People with Dementia.

    PubMed

    Garrie, Alaina J; Goel, Shruti; Forsberg, Martin M

    2016-01-01

    Purpose. Researchers assessed whether medical students' participation in a poetry workshop with people with Alzheimer's disease and related dementias (ADRD) affected their attitudes towards persons with ADRD. Objective. To add to the growing body of research summarizing the impact of nonclinical interventions on medical students' perspectives about people with ADRD. Design. Researchers used dementia attitudes scale (DAS) and interpretive phenomenological analysis (IPA) to analyze participants' attitudes. Setting. Osteopathic medical school and dementia care unit in the state of New Jersey. Participants. Eleven out of fourteen medical students completed the study. Measurements. Emerging themes were classified from the postintervention semistructured interviews and descriptive statistics were used to compare the preintervention to postintervention DAS. Results. Researchers found statistically significant differences between preintervention and postintervention DAS scores. Study participants scored a preintervention DAS mean, 107.09 (SD = 11.85), that changed positively and significantly to the postintervention DAS mean, 121.82 (SD = 10.38). DAS subdomains, "comfort" (P = 0.002) and "knowledge" (P = 0.01), and eleven of the twenty DAS items underwent a positive and statistically significant shift from preintervention to postintervention. IPA of the interviews yielded five primary and five secondary themes, supporting the measured statistical outcomes. Conclusion. Medical students' participation in a poetry workshop, with people with ADRD, positively impacts their attitudes.

  17. A novel double antibody sandwich-lateral flow immunoassay for the rapid and simple detection of hepatitis C virus.

    PubMed

    Xiang, Tingxiu; Jiang, Zheng; Zheng, Jian; Lo, Chaoyu; Tsou, Harry; Ren, Guosheng; Zhang, Jun; Huang, Ailong; Lai, Guoqi

    2012-11-01

    The objective of this study was to screen for antigens of the hepatitis C virus (HCV) to establish a new double antibody sandwich-lateral flow immunoassay (DAS-LFIA) method for testing the presence of anti-HCV antibodies in human serum or plasma. A series of different recombinant HCV proteins in Escherichia coli cells were constructed, expressed, purified and the new DAS-LFIA strip was developed. The sensitivity and specificity of new the DAS-LFIA strip were evaluated by detecting 23 HCV-positive sera, a set of quality control references for anti-HCV detection that contain known amounts of anti-HCV antibodies, and 8 HCV-negative sera. A total of 300 clinical serum samples was examined by both the new DAS-LFIA strip and enzyme-linked immunosorbent assay (ELISA). Data were analyzed using SPSS 11.5 software. The sensitivity and specificity of the new DAS-LFIA strip were 100%. The lowest test line of the HCV DAS-LFIA strips was 2 NCU/ml. Additionally, the concordance between the new DAS-LFIA strip and ELISA methods was 94.33%. In conclusion, our new testing method is rapid, simple, sensitive and specifically detects the presence of anti-HCV antibodies in human serum or plasma. Therefore, it may be used for monitoring HCV.

  18. Protective Effects of Diallyl Sulfide against Thioacetamide-Induced Toxicity: A Possible Role of Cytochrome P450 2E1

    PubMed Central

    Kim, Nam Hee; Lee, Sangkyu; Kang, Mi Jeong; Jeong, Hye Gwang; Kang, Wonku; Jeong, Tae Cheon

    2014-01-01

    Effects of diallyl sulfide (DAS) on thioacetamide-induced hepatotoxicity and immunotoxicity were investigated. When male Sprague-Dawley rats were treated orally with 100, 200 and 400 mg/kg of DAS in corn oil for three consecutive days, the activity of cytochrome P450 (CYP) 2E1-selective p-nitrophenol hydroxylase was dose-dependently suppressed. In addition, the activities of CYP 2B-selective benzyloxyresorufin O-debenzylase and pentoxyresorufin O-depentylase were significantly induced by the treatment with DAS. Western immunoblotting analyses also indicated the suppression of CYP 2E1 protein and/or the induction of CYP 2B protein by DAS. To investigate a possible role of metabolic activation by CYP enzymes in thioacetamide-induced hepatotoxicity, rats were pre-treated with 400 mg/kg of DAS for 3 days, followed by a single intraperitoneal treatment with 100 and 200 mg/kg of thioacetamide in saline for 24 hr. The activities of serum alanine aminotransferase and aspartate aminotransferase significantly elevated by thioacetamide were protected in DAS-pretreated animals. Likewise, the suppressed antibody response to sheep erythrocytes by thioacetamide was protected by DAS pretreatment in female BALB/c mice. Taken together, our present results indicated that thioacetamide might be activated to its toxic metabolite(s) by CYP 2E1, not by CYP 2B, in rats and mice. PMID:24753821

  19. A 14-month study of change in disability and mood state in patients with chronic migraine associated to medication overuse.

    PubMed

    Raggi, A; Leonardi, M; Giovannetti, A M; Schiavolin, S; Bussone, G; Grazzi, L; Usai, S; Curone, M; Di Fiore, P; D'Amico, D

    2013-05-01

    This paper aims to evaluate changes in disease severity, disability and mood state in patients with chronic migraine associated to medication overuse (CM-MO). MIDAS was used for assessing disease activity, WHO-DAS-2 for disability, DBI-2 for mood state. ANOVA was used to test change over time; t-test to assess follow-up differences in WHO-DAS-2 and BDI-2 between patients with MIDAS ≤20 and ≥21. Change in MIDAS, WHO-DAS-2 and BDI-2 scores were computed: Pearson's index was used to assess correlation between them; linear regression to assess change in WHO-DAS-2, using MIDAS and BDI-2 change as predictors. Mean MIDAS decreased significantly (from 101.9 to 52.0). In 26.1 % of the sample, MIDAS fell below 21 at follow-up: these patients had lower WHO-DAS-2 score. WHO-DAS-2 change was little correlated to MIDAS change and strongly correlated to changes in BDI-2 scores. 57.1 % of WHO-DAS-2 change variance is explained by change in BDI-2 and MIDAS scores. There was a clear clinical improvement 14 months after detoxification, and a modest reduction in disability which is explained by reduced disease activity and improved mood state. An appropriate treatment of CM-MO, based on detoxification and prophylaxis, is likely to reduce disease burden: recognition and treatment of mood problems may be a key factor to reduce disability.

  20. Medical Students' Perceptions of Dementia after Participation in Poetry Workshop with People with Dementia

    PubMed Central

    Garrie, Alaina J.; Goel, Shruti; Forsberg, Martin M.

    2016-01-01

    Purpose. Researchers assessed whether medical students' participation in a poetry workshop with people with Alzheimer's disease and related dementias (ADRD) affected their attitudes towards persons with ADRD. Objective. To add to the growing body of research summarizing the impact of nonclinical interventions on medical students' perspectives about people with ADRD. Design. Researchers used dementia attitudes scale (DAS) and interpretive phenomenological analysis (IPA) to analyze participants' attitudes. Setting. Osteopathic medical school and dementia care unit in the state of New Jersey. Participants. Eleven out of fourteen medical students completed the study. Measurements. Emerging themes were classified from the postintervention semistructured interviews and descriptive statistics were used to compare the preintervention to postintervention DAS. Results. Researchers found statistically significant differences between preintervention and postintervention DAS scores. Study participants scored a preintervention DAS mean, 107.09 (SD = 11.85), that changed positively and significantly to the postintervention DAS mean, 121.82 (SD = 10.38). DAS subdomains, “comfort” (P = 0.002) and “knowledge” (P = 0.01), and eleven of the twenty DAS items underwent a positive and statistically significant shift from preintervention to postintervention. IPA of the interviews yielded five primary and five secondary themes, supporting the measured statistical outcomes. Conclusion. Medical students' participation in a poetry workshop, with people with ADRD, positively impacts their attitudes. PMID:26977333

  1. Extension to distributed annotation system: Summary and summaryplot commands.

    PubMed

    Chrysostomou, Charalambos; Brookes, Anthony J

    2015-01-01

    In recent years, the development of high-throughput sequencing technologies provided an effective way to generate data from entire genomes and test variants from thousands of individuals. The information acquired from analysing the data generated from high-throughput sequencing technologies provided useful insights into applications like whole-exome sequencing and targeted sequencing to discover the genetic cause of complex diseases and drug responses. The Distributed Annotation System (DAS) is one of the proposed solution developed to share and unify biological data from multiple local and remote DAS annotation servers. The researchers can use DAS to request data from federated or centralised databases and integrate them into a unified view. Furthermore, with the use of Reference DAS servers, structural and sequence data can be used to accompany annotation data, for the pursue of new knowledge for a particular feature or region. In this paper, two additional commands, summary and summary-plot commands, to the existing DAS protocol are proposed and implemented. The proposed commands were created in order to give the users the capabilities to request a summary of features for a particular region of interest. The summary command was created in order to extend the capabilities of the current DAS protocol, while the summaryplot command was created to provide a more user-friendly alternative to standard XML DAS responses. Finally, three examples are presented based on the GENCODE annotation data.

  2. Evaluation of Transport in the Lower Tropical Stratosphere in a Global Chemistry and Transport Model

    NASA Technical Reports Server (NTRS)

    Douglass, Anne R.; Schoeberl, Mark R.; Rood, Richard B.; Pawson, Steven

    2002-01-01

    A general circulation model (GCM) relies on various physical parameterizations and provides a solution to the atmospheric equations of motion. A data assimilation system (DAS) combines information from observations with a GCM forecast and produces analyzed meteorological fields that represent the observed atmospheric state. An off-line chemistry and transport model (CTM) can use winds and temperatures from a either a GCM or a DAS. The latter application is in common usage for interpretation of observations from various platforms under the assumption that the DAS transport represents the actual atmospheric transport. Here we compare the transport produced by a DAS with that produced by the particular GCM that is combined with observations to produce the analyzed fields. We focus on transport in the tropics and middle latitudes by comparing the age-of-air inferred from observations of SF6 and CO2 with the age-of-air calculated using GCM fields and DAS fields. We also compare observations of ozone, total reactive nitrogen, and methane with results from the two simulations. These comparisons show that DAS fields produce rapid upward tropical transport and excessive mixing between the tropics and middle latitudes. The unrealistic transport produced by the DAS fields may be due to implicit forcing that is required by the assimilation process when there is bias between the GCM forecast and observations that are combined to produce the analyzed fields. For example, the GCM does not produce a quasi-biennial oscillation (QBO). The QBO is present in the analyzed fields because it is present in the observations, and systematic implicit forcing is required by the DAS. Any systematic bias between observations and the GCM forecast used to produce the DAS analysis is likely to corrupt the transport produced by the analyzed fields. Evaluation of transport in the lower tropical stratosphere in a global chemistry and transport model.

  3. Cytotoxicity of diacetoxyscirpenol is associated with apoptosis by activation of caspase-8 and interruption of cell cycle progression by down-regulation of cdk4 and cyclin B1 in human Jurkat T cells

    SciTech Connect

    Jun, Do Youn; Kim, Jun Seok; Park, Hae Sun; Song, Woo Sun; Bae, Young Seuk; Kim, Young Ho . E-mail: ykim@knu.ac.kr

    2007-07-15

    To understand the mechanism underlying T-cell toxicity of diacetoxyscirpenol (DAS) from Fusarium sambucinum, its apoptogenic as well as growth retardation activity was investigated in human Jurkat T cells. Exposure to DAS (0.01-0.15 {mu}M) caused apoptotic DNA fragmentation along with caspase-8 activation, Bid cleavage, mitochondrial cytochrome c release, activation of caspase-9 and caspase-3, and PARP degradation, without any alteration in the levels of Fas or FasL. Under these conditions, necrosis was not accompanied. The cytotoxicity of DAS was not blocked by the anti-Fas neutralizing antibody ZB-4. Although the DAS-induced apoptotic events were completely prevented by overexpression of Bcl-xL, the cells overexpressing Bcl-xL were unable to divide in the presence of DAS, resulting from the failure of cell cycle progression possibly due to down-regulation in the protein levels of cdk4 and cyclin B1. The DAS-mediated apoptosis and activation of caspase-8, -9, and -3 were abrogated by either pan-caspase inhibitor (z-VAD-fmk) or caspase-8 inhibitor (z-IETD-fmk). While the DAS-mediated apoptosis and activation of caspase-9 and caspase-3 were slightly suppressed by the mitochondrial permeability transition pore inhibitor (CsA), both caspase-8 activation and Bid cleavage were not affected by CsA. The activated normal peripheral T cells possessed a similar susceptibility to the cytotoxicity of DAS. These results demonstrate that the T-cell toxicity of DAS is attributable to not only apoptosis initiated by caspase-8 activation and subsequent mitochondrion-dependent or -independent activation of caspase cascades, which can be regulated by Bcl-xL, but also interruption of cell cycle progression caused by down-regulation of cdk4 and cyclin B1 proteins.

  4. Diallylsulfide attenuates excessive collagen production and apoptosis in a rat model of bleomycin induced pulmonary fibrosis through the involvement of protease activated receptor-2

    SciTech Connect

    Kalayarasan, Srinivasan Sriram, Narayanan; Soumyakrishnan, Syamala; Sudhandiran, Ganapasam

    2013-09-01

    Pulmonary fibrosis (PF) can be a devastating lung disease. It is primarily caused by inflammation leading to severe damage of the alveolar epithelial cells. The pathophysiology of PF is not yet been clearly defined, but studying lung parenchymal injury by involving reactive oxygen species (ROS) through the activation of protease activated receptor-2 (PAR-2) may provide promising results. PAR-2 is a G-protein coupled receptor is known to play an important role in the development of PF. In this study, we investigated the inhibitory role of diallylsulfide (DAS) against ROS mediated activation of PAR-2 and collagen production accompanied by epithelial cell apoptosis. Bleomycin induced ROS levels may prompt to induce the expression of PAR-2 as well as extracellular matrix proteins (ECM), such as MMP 2 and 9, collagen specific proteins HSP-47, α-SMA, and cytokines IL-6, and IL-8RA. Importantly DAS treatment effectively decreased the expression of all these proteins. The inhibitory effect of DAS on profibrotic molecules is mediated by blocking the ROS level. To identify apoptotic signaling as a mediator of PF induction, we performed apoptotic protein expression, DNA fragmentation analysis and ultrastructural details of the lung tissue were performed. DAS treatment restored all these changes to near normalcy. In conclusion, treatment of PF bearing rats with DAS results in amelioration of the ROS production, PAR-2 activation, ECM production, collagen synthesis and alveolar epithelial cell apoptosis during bleomycin induction. We attained the first evidence that treatment of DAS decreases the ROS levels and may provide a potential therapeutic effect attenuating bleomycin induced PF. - Highlights: • DAS inhibits PAR-2 activity; bleomycin stimulates PAR-2 activity. • Increase in PAR-2 activity is correlated with pulmonary fibrosis • DAS reduces pro-inflammatory activity linked to facilitating pulmonary fibrosis. • DAS inhibits apoptosis of alveolar epithelial cells.

  5. Computer-Supplemented Structural Drill Practice Versus Computer-Supplemented Semantic Drill Practice by Beginning College German Students: A Comparative Experiment

    DTIC Science & Technology

    1979-01-01

    Mittagessen (schmecken) im Restaurant. Now 82 B. Das Auto (bauen) ein Einfamilienhaus. Mein Vater (kosten) viel Geld . C. Peter (dauern) Anna die Kirche. Das...Firma VergntlgenHerbst Prtiffung Studentin Geld VerkehrHerr Sache S~1den Geschichte WaschmaschineKind Salz Wein Glas WeileMann Seife Zeit Min.te...95 I B. Das Auto (bauen) in aus% Man Vater (kosten) viol 1I. Sentence no. 1 :Dos Auto hat viol Geld aekostot. Sentence no. 2 :Mein Vater hat ein Haus

  6. Magnetic white dwarf stars in the Sloan Digital Sky Survey

    NASA Astrophysics Data System (ADS)

    Kepler, S. O.; Pelisoli, I.; Jordan, S.; Kleinman, S. J.; Koester, D.; Külebi, B.; Peçanha, V.; Castanheira, B. G.; Nitta, A.; Costa, J. E. S.; Winget, D. E.; Kanaan, A.; Fraga, L.

    2013-03-01

    To obtain better statistics on the occurrence of magnetism among white dwarfs, we searched the spectra of the hydrogen atmosphere white dwarf stars (DAs) in the Data Release 7 of the Sloan Digital Sky Survey (SDSS) for Zeeman splittings and estimated the magnetic fields. We found 521 DAs with detectable Zeeman splittings, with fields in the range from around 1 to 733 MG, which amounts to 4 per cent of all DAs observed. As the SDSS spectra have low signal-to-noise ratios, we carefully investigated by simulations with theoretical spectra how reliable our detection of magnetic field was.

  7. Web-based data acquisition and management system for GOSAT validation Lidar data analysis

    NASA Astrophysics Data System (ADS)

    Okumura, Hiroshi; Takubo, Shoichiro; Kawasaki, Takeru; Abdullah, Indra N.; Uchino, Osamu; Morino, Isamu; Yokota, Tatsuya; Nagai, Tomohiro; Sakai, Tetsu; Maki, Takashi; Arai, Kohei

    2012-11-01

    An web-base data acquisition and management system for GOSAT (Greenhouse gases Observation SATellite) validation lidar data analysis is developed. The system consists of data acquisition sub-system (DAS) and data management sub-system (DMS). DAS written in Perl language acquires AMeDAS ground-level meteorological data, Rawinsonde upper-air meteorological data, ground-level oxidant data, skyradiometer data, skyview camera images, meteorological satellite IR image data and GOSAT validation lidar data. DMS written in PHP language demonstrates satellite-pass date and all acquired data.

  8. Availability of food stores and consumption of fruit, legumes and vegetables in a Brazilian urban area.

    PubMed

    Cristine Pessoa, Milene; Loures Mendes, Larissa; Teixeira Caiaffa, Waleska; Carvalho Malta, Deborah; Velásquez-Meléndez, Gustavo

    2014-12-17

    Antecedentes: El ambiente alimentar puede tener una influencia importante en la disponibilidad y el acceso a ellos, éste desempeña un papel importante en la salud de las poblaciones. El objetivo de este estudio fue comparar el consumo de frutas, legumbres y hortalizas (FLV) de adultos y la disponibilidad de las tiendas de alimentos en el contexto del espacio socioeconómico y geográfico en el territorio de las unidades básicas de salud en una capital brasileña. Métodos: El estudio se desarrolló a partir de la información obtenida a través de la Vigilancia de Factores de Riesgo para Enfermedades no Transmisibles Prevención de Encuesta Telefónica (VIGITEL), utilizando muestras de la ciudad de Belo Horizonte en los años de 2008 a 2010. Un total de 5.611 registros fueron geo-codificados usando el código postal. Una puntuación fue creada en base a la frecuencia semanal y diario del consumo de FLV . El área de las unidades básicas de salud se utilizó como unidad vecinal. Se utilizaron los datos geo-referenciados de los comercios de venta de comida en la ciudad y el barrio. Resultados: A medida que aumentaba la renta del barrio, hubo un aumento en la distribución de los establecimientos de comida e bebidas para todas las categorías estudiadas. Se observaron las puntuaciones más altas de consumo FLV en zonas con niveles de ingresos más altos. Conclusión: La mayor concentración de tiendas de alimentos e bebidas e mayor puntuación de consumo, independientemente da calidad de los productos ofrecidos, fue observado en las áreas geográficas con mayor poder adquisitivo.

  9. [Parenteral administration medicines: recommendations of preparation, administration and stability].

    PubMed

    Gaspar Carreño, M; Torrico Martín, F; Novajarque Sala, L; Batista Cruz, M; Ribeiro Gonçalves, P; Porta Oltra, B; Sánchez Santos, J C

    2014-11-03

    Objetivo: Elaborar unas recomendaciones de preparacion de medicamentos de administracion parenteral (MAP) para valorar la posibilidad de transferir su preparacion, desde las unidades de enfermeria en planta de hospitalizacion al servicio de farmacia (SF). Método: Se procede a elaborar una tabla de estabilidades de los medicamentos incluidos en la guia farmacoterapeutica del Hospital, aplicando la Guia USP (Pharmaceutical compounding Sterile Preparations) y la Guia de de buenas practicas de preparacion de medicamentos en los servicios de farmacia hospitalaria. Se recopilo informacion sobre las MAP: metodo de preparacion, compatibilidad, conservacion, periodo de validez, modo de administracion y tipo de envase. Los datos se obtuvieron mediante consulta de las fichas tecnicas, laboratorios, revision bibliografica y otras bases de datos. Resultados: Tras revisar 209 farmacos se elaboro un listado de recomendaciones. Segun los datos obtenidos, las MAP se prepararan de la siguiente forma: 89 seran preparadas desde el SF, 62 en unidad de enfermeria en planta de hospitalizacion pues son medicamentos que requieren administracion inmediata y 58 ya van acondicionados para su administracion por la industria. De los 62 farmacos que se prepararan por enfermeria, en 14 de ellos las dosis siguientes se prepararan desde el SF. Por lo tanto de los 209 farmacos solo 48 se prepararan exclusivamente en la unidad de enfermeria. Conclusiones: Desde el SF se ha establecido un metodo normalizado de preparacion, conservacion, administracion y periodo de validez de MAP. La preparacion de MAP en SF ampliaria su tiempo de conservacion, al tener en cuenta la estabilidad fisicoquimica, el nivel de riesgo y la vulnerabilidad del preparado a la contaminacion microbiologica. La informacion aportada contribuira a una disminucion de errores asociados al proceso de preparacion y administracion de MAP.

  10. [Charles Bonnet syndrome. A 45-case series].

    PubMed

    Santos-Bueso, Enrique; Serrador-García, Mercedes; Porta-Etessam, Jesús; Rodríguez-Gómez, Octavio; Martínez-de-la-Casa, José M; García-Feijoo, Julián; García-Sánchez, Julián

    2015-04-16

    Introduccion. El sindrome de Charles Bonnet (SCB) es un cuadro clinico que se caracteriza por la presencia de alucinaciones visuales, principalmente complejas, en pacientes con estado cognitivo conservado e importante deterioro de la vision. El incremento del SCB se debe al aumento de la esperanza de vida y al desarrollo de patologias asociadas al envejecimiento, como la degeneracion macular asociada a la edad. Pacientes y metodos. Se estudian las caracteristicas de una serie de 45 pacientes diagnosticados de SCB en la unidad de neurooftalmologia del Hospital Clinico San Carlos. Los pacientes procedian de las unidades de patologia macular, glaucoma, superficie ocular y urgencias, en las que fueron diagnosticados de SCB, que se confirmo en la unidad multidisciplinar formada por oftalmologia, neurologia y psiquiatria del mismo hospital. Resultados. El 66,66% eran mujeres, de mas de 80 anos (68,88%), principalmente con degeneracion macular asociada a la edad (37,77%). Las alucinaciones que los pacientes presentaban con mas frecuencia eran personas y caras (35,55%), en color (66,66%), en movimiento (80%), con un tiempo de evolucion de 6-12 meses (26,66%), frecuencia de tres episodios al dia (35,55%) y de 3-5 minutos de duracion (35,55%). Conclusiones. El SCB es un complejo sindrome cuya incidencia se esta incrementando en nuestras consultas y que precisa un abordaje multidisciplinar entre oftalmologos, neurologos y psiquiatras para evitar diagnosticos erroneos y proporcionar un tratamiento adecuado. Son necesarios nuevos estudios para un conocimiento mas profundo y adecuado del SCB.

  11. Female breast symptoms in patients attended in the family medicine practice.

    PubMed

    González-Pérez, Brian; Salas-Flores, Ricardo; Sosa-López, María Lucero; Barrientos-Guerrero, Carlos Eduardo; Hernández-Aguilar, Claudia Magdalena; Gómez-Contreras, Diana Edith; Sánchez-Garza, Jorge Arturo

    2013-01-01

    Introducción: en México, en las unidades del primer nivel hay pocos estudios sobre los síntomas mamarios. El objetivo fue determinar la frecuencia de los síntomas y los más asociados con el diagnóstico de cáncer. Métodos: se recabó información de las pacientes atendidas de 2006 a 2010 con enfermedad de mama de una unidad de medicina familiar. Se determinaron las frecuencias de los síntomas mamarios en los grupos etarios < 19, 20-49, 50-69, > 70 años y los cocientes de probabilidad (LR) de cáncer de mama para cada síntoma, con un intervalo de confianza (IC) de 95 %. Resultados: casi todas las quejas derivaron de una masa o tumoración (71.7 %) y dolor mamario (67.7 %). Presentaron cáncer de mama 120 mujeres, con un promedio de edad de 53.51 + 12.7 años. La tumoración/masa en el seno tuvo un LR+ para cáncer de mama de 4.53 (IC 95 % = 2.51-8.17) y un LR+ para dolor mamario de 1.08, 95 % (IC 95 % = 1.05-1.11). Conclusiones: la presentación de la tumoración/masa predominó como queja en nuestra unidad y estuvo asociada con un LR+ para cáncer de mama.

  12. Proceedings of the Joint Conference on Magnetism and Magnetic Materials (6th) Held at Albuquerque, New Mexico on 20-23 June 1994. (Journal of Applied Physics. Volume 76, Number 10, Part 2)

    DTIC Science & Technology

    1994-06-23

    de la Fuente, M. Ciria, and E. Joven Unidad de Magnetismo , Departamento de Fisica de la Materia Condensada and ICMA, Universidad de Zaragoza and...and A. Hernando Instituto de Magnetismo Aplicado, P0. Box 155, Las Rozas, 28230 Madrid, Spain A. Garcia Escorial CENIM-CSIC, Avenida, Gregoria del Amo 8...from 0.02 to 1.6 Oe a Dpto. de Electricidad , Univ. de Valladolid, E-47071 Vaiadolid, Spain. for frequencies from 1 to 20 kHz. J. Appl. Ptys. 76 (10

  13. [An automated registry program for nosocomial infections].

    PubMed

    Castañón-González, Jorge Alberto; Polanco-González, Carlos; Samaniego-Mendoza, José Lino; Buhse, Thomas

    2014-12-01

    Las infecciones nosocomiales presentan un gran reto para la medicina hospitalaria, en general, y para las Unidades de Cuidados Intensivos, en particular. Su elevada prevalencia, la gran morbilidad y mortalidad asociadas, el incremento de la estancia hospitalaria y, en consecuencia, los costos de la atención médica han hecho que los programas de vigilancia, control y prevención de infecciones nosocomiales sean una parte toral de los protocolos de seguridad para el paciente y un indicador de calidad de la atención médica.

  14. SOARD Overview: Southern Office of Aerospace Research and Development

    DTIC Science & Technology

    2012-03-06

    making investment into Brazilian science: Example $0.7B USD PETROBRAS R &D Center, $1.5B USD Global Tech Center Federal Univ of Rio de Janeiro* #1...unlimited. 0 2 4 6 8 10 12 RSA 0 2 4 6 8 10 12 RSL 0 2 4 6 8 10 12 RSE COUNTRY WOS CSP R & D new starts/total Argentina 0 1 0 / 4...Dallas) • “Multiphase Multifunctional Ceramic Coatings” – Centro de investigación y de Estudios Avanzados del Instituto Politecnico Nacional Unidad

  15. The Mexican Expeditionary Air Force in World War II: The Organization, Training, and Operations of the 201st Squadron

    DTIC Science & Technology

    1997-03-01

    las Fuerzas Aéreas de los Estados Unidos para su entrenamiento y envío a la unidad. (6) Las comunicaciones oficiales entre el Escuadrón Aéreo...Low altitude navigation 14. Combined training x Aerial Gunnery (20 missions) x Post-Gunnery - Unit training (16 missions) x One hundred and fifty...hour pilot (8 missions) 15. High Altitude Combat 16. Theater tactics The program contemplated 107 missions and about 120:00 hr. to be conducted in about

  16. [XII National Forum on Health Education].

    PubMed

    Ramiro-H, Manuel

    2015-01-01

    In Guadalajara, on August 19, 20 and 21 was held the XII Foro Nacional de Educación en Salud, in line with the interest that both, the Dirección General and the Dirección de Prestaciones Médicas of the IMSS, have in training and updating the human resources for the care of the beneficiaries. The Unidad de Educación, Investigación y Políticas de Salud organized a meeting in which the actors of these tasks, the institutional staff and authorities from various universities worked together with the IMSS.

  17. Ckoirama, the first Chilean--state owned observatory under desert skies

    NASA Astrophysics Data System (ADS)

    Char, F.; Unda-Sanzana, E.; Colque, J.; Fossey, S.; Rocchetto, M.

    2016-08-01

    The following work wants to introduce Ckoirama, the first public professional observatory of Chile, under the clear skies of the Atacama desert. Operated by the Unidad de Astronomia of the Universidad de Antofagasta, it was conceived to perform scientific operations, through its main 0.6 m telescope, but it will also be open for educational purposes, communicating astronomy to the public through a secondary 0.35 m telescope. Ckoirama will not only be an opportunity to make autonomous observations; this is also an important message to the astronomical community, because this is the first step toward a highlighted presence of Chile and a new commitment to invest in the astronomical research.

  18. [Not Available].

    PubMed

    López-Fuenzalida, Antonio; Valdés-Badilla, Pablo; Herrera-Valenzuela, Tomás; Rodríguez Canales, Carolina; Reyes Ponc, Álvaro; Arriaza Ardiles, Enrique; Durán Agüero, Samuel

    2016-06-30

    Introducción: la categorización del estado nutricional a través del índice de masa corporal (IMC) es uno de los recursos de valoración clínica más utilizados en el síndrome metabólico (SM). Sin embargo, es desconocida su capacidad para identificar las diferencias en la composición corporal.Objetivo: determinar si las variaciones en el estado nutricional se reflejan en la composición corporal en mujeres con SM e identificar la concordancia de clasificación del riesgo cardiometabólico entre el estado nutricional e índices antropométricos.Material y métodos: la muestra incluyó 136 mujeres (edad 42 ± 3,5 años) con SM. Se evaluó el estado nutricional, masa muscular, masa adiposa, perímetro de cintura (PC), índice cintura-cadera (ICC) e índice cintura-estatura (ICE). Se compararon los valores de composición corporale índices antropométricos; adicionalmente se determinó la concordancia clasificatoria del riesgo cardiometabólico entre los índices y el IMC.Resultados: solo la edad (p = 0,358), estatura (p = 0,209) y porcentaje de adiposidad (p = 0,234) no mostraron diferencias significativas entre los grupos. La mejor concordancia clasificatoria del riesgo cardiometabólico se observó en el PC > 88 cm (94,9%) e ICE ≥ 0,5 (94,1%) al categorizar el IMC en normopeso vs. exceso de peso; mientras que el PC > 88 cm obtuvo mejor concordancia separando al grupo en normopeso-sobrepesovs. obesidad (85,3%), aunque la sensibilidad y especificidad fueron más homogéneas con el ICC ≥ 0,85.Conclusión: el IMC no logra identificar las variaciones de la adiposidad corporal en mujeres con SM agrupadas según su estado nutricional. El IMC presenta mejor sensibilidad que especificidad respecto a los índices considerados para determinar riesgo cardiometabólico en mujeres con SM.

  19. Accuracy of body mass index for age to diagnose obesity in Mexican schoolchildren.

    PubMed

    Mendoza Pablo, Pedro A; Valdés, Jesús; Ortiz-Hernández, Luis

    2015-06-01

    Objetivo: comparar la exactitud de tres referencias del IMC para la edad (de la Organización Mundial de la Salud, OMS; de la International Obesity Task Force, IOTF; y de los Centros para el Control y Prevención de Enfermedades (CDC) de las tablas de crecimiento) para diagnosticar obesidad en niños mexicanos. Métodos: se evaluó una muestra por conveniencia de escolares de la ciudad de México (n = 218). El estándar de oro fue el porcentaje de grasa corporal estimado por la técnica de dilución de deuterio. Se estimaron la sensibilidad y la especificidad del punto de corte clásico del IMC para la edad para identificar obesidad (i.e. > 2.0 desviaciones estándar, DE). La exactitud (i.e., área bajo la curva, ABC) de las tres referencias del IMC para el diagnóstico de la obesidad se estimó con el método de curvas ROC. Se identificó el punto de corte óptimo (PCO). Resultados: los puntos de corte para identificar obesidad tuvieron baja (OMS: 57.6% y CDC: 53.5%) o muy baja (IOTF referencia: 40,4%) sensibilidad, pero especificidades adecuadas (91.6%, 95.0% y 97.5%, respectivamente). El ABC de las tres referencias fueron adecuadas (0.89). Entre los niños mayores la referencia de la IOTF tuvo el menor ABC. El PCO para la referencia de los CDC (1.24 DE) fue menor que el PCO para la de la OMS (1.53 DE) y la de la IOTF (1.47 DE). Conclusiones: el punto de corte clásico para la obesidad tiene baja sensibilidad, especialmente para la referencia de la IOTF. La exactitud de las tres referencias fue similar. Sin embargo, para obtener el diagnóstico comparable de obesidad en diferentes puntos de corte se debe utilizar en función de la referencia seleccionada.

  20. Open-field host specificity test of Gratiana boliviana (Coleoptera: Chrysomelidae), a biological control agent of tropical soda apple (Solanaceae) in the United States

    SciTech Connect

    Gandolfo, D.; McKay, F.; Medal, J.C.; Cuda, J.P.

    2007-03-15

    An open-field experiment was conducted to assess the suitability of the South American leaf feeding beetle Gratiana boliviana Spaeth for biological control of Solanum viarum Dunal in the USA. An open-field test with eggplant, Solanum melongena L., was conducted on the campus of the University of Buenos Aires, Argentina, and a S. viarum control plot was established 40 km from the campus. One hundred adult beetles were released in each plot at the beginning of the experiment during the vegetative stage of the plants, and forty additional beetles were released in the S. melongena plot at the flowering stage. All the plants in each plot were checked twice a week and the number of adults, immatures, and eggs recorded. Results showed almost a complete rejection of eggplant by G. boliviana. No noticeable feeding damage was ever recorded on eggplant. The experiment was ended when the eggplants started to senesce or were severely damaged by whiteflies and spider mites. The results of this open-field experiment corroborate previous quarantine/laboratory host-specificity tests indicating that a host range expansion of G. boliviana to include eggplant is highly unlikely. Gratiana boliviana was approved for field release in May 2003 in the USA. To date, no non-target effects have been observed either on eggplant or native species of Solanum. (author) [Spanish] Una prueba de campo fue conducida para evaluar la especificidad del escarabajo suramericano defoliador Gratiana boliviana Spaeth para control biologico de Solanum viarum Dunal en los Estados Unidos. La prueba con berenjena se realizo en el campo experimental de la Universidad de Buenos Aires, Argentina, y una parcela control con S. viarum fue establecida a 40 km. Cien escarabajos adultos fueron liberados en cada parcela al inicio del experimento durante la fase vegetativa, y cuarenta escarabajos adicionales fueron liberados en la parcela de berenjena durante la floracion. Todas las plantas en cada parcela fueron

  1. [Total immunoglobulin E as marker of allergy at Northeast of Mexico].

    PubMed

    Ramírez-Enríquez, Francisca; Prado-Rendón, Jesús; Lachica-Valle, Jesús; Valle-Leal, Jaime

    2016-01-01

    Antecedentes: la relación entre IgE total en suero y alergia se ha estudiado para determinar si puede ser un complemento útil para el diagnóstico de alergia. Objetivo: conocer si la IgE sérica total es una herramienta útil en el diagnóstico de alergia en la población pediátrica que acude a la consulta externa de Alergología pediátrica del Hospital General Regional 1, Ciudad Obregón, Sonora. Material y método: estudio epidemiológico, observacional, retrospectivo, transversal y analítico de prueba diagnóstica, en el que se revisaron los expedientes de niños entre 3 y 16 años de edad, atendidos en el servicio de Alergología pediátrica. Para el análisis estadístico se utilizó el programa SPSS versión 22 y por medio de una tabla tetracórica se determinó la sensibilidad y especificidad de IgE para el diagnóstico de alergias; se tomaron pruebas cutáneas como patrón de referencia para el diagnóstico de alergias. Se determinó el valor de p entre las variables de estudio con la prueba t de Student. Resultados: se estudiaron 248 expedientes, el género masculino fue más frecuente (59%). La sensibilidad de IgE fue de 85% y la especificidad de 20%; el punto de corte encontrado fue de 148 UI/mL, concentraciones elevadas de IgE en pruebas cutáneas para aeroalergenos y existencia de síntomas respiratorios. Conclusiones: la determinación de IgE es una prueba útil de tamizaje inicial en pacientes con sospecha de alergia.

  2. ANTHROPOMETRY TO IDENTIFY HIGH VISCERAL FAT AREA IN POSTMENOPAUSAL WOMEN.

    PubMed

    Gondim Pitanga, Francisco José; Seara Pitanga, Cristiano Penas; Calçada Dias Gabriel, Ronaldo Eugénio; Cristina Beck, Carmem; Rodrigues Moreira, Maria Helena

    2015-12-01

    Introducción: la evaluación de la distribución de la grasa corporal por antropometría puede servir para identificar el exceso de grasa visceral. Este diagnóstico permitirá la aplicación de medidas específicas para prevenir y tratar el exceso de grasa visceral en mujeres posmenopáusicas. Objetivo: el objetivo de este estudio fue analizar diferentes indicadores antropométricos e identificar los mejores puntos de corte para discriminar sujetos con alta área de grasa visceral (AAGS) en mujeres posmenopáusicas. Métodos: estudio transversal con una muestra de 255 mujeres posmenopáusicas. Se construyeron diferentes curvas Receiver Operating Characteristic (ROC) y las áreas bajo ellas comparadas en términos del índice de conicidad (índice C), el índice de masa corporal (IMC), razón cintura-cadera (RCC), circunferencia de la cintura (CC), relación cintura-estatura (RCEst) y AAGS. La sensibilidad y la especificidad identificaron los mejores puntos de corte entre los diferentes indicadores antropométricos para discriminar sujetos con AAGS. El intervalo de confianza se fijó en 95%. Resultados: las zonas estadísticamente significativas bajo la curva ROC se encontraron para todos los indicadores antropométricos analizados. Fueron sugeridos los siguientes puntos de corte, con sus respectivas sensibilidades y especificidades, para discriminar sujetos con AAGS: índice C (1,19; 75,00%–74,77%); IMC (27,3 kg / m2; 81,08%–80,37%); RCC (0,98; 90,54%-83,18%); CC (85 cm; 85,14%-81,31%); y RCEst (0,55; 80,41%–80,37%). Conclusión: estos resultados demuestran que los indicadores antropométricos identifican bien a las mujeres postmenopáusicas con AAGS y pueden ser utilizados en lugar de los exámenes más sofisticados para detectar altos niveles de grasa visceral.

  3. [Efficacy and effectiveness of different nutritional screening tools in a tertiary hospital].

    PubMed

    Calleja Fernández, Alicia; Vidal Casariego, Alfonso; Cano Rodríguez, Isidoro; Ballesteros Pomar, María D

    2015-05-01

    Introducción: La elevada prevalencia de desnutrición en el medio hospitalario y sus repercusiones hacen necesario el empleo de herramientas de cribado nutricional para su detección, diagnóstico y tratamiento precoz. Objetivo: Evaluar la herramienta de cribado nutricional más adecuada para el paciente hospitalizado en un hospital de tercer nivel, a nivel global y por servicios de hospitalización. Metodología: Estudio transversal realizado en condiciones de práctica clínica habitual. Se evaluaron 4 métodos de cribado nutricional: Valoración Subjetiva Global (VSG), Mini Nutritional Assessment (MNA), Malnutrition Universal Screening Tool (MUST) y Nutritional Risk Screening 2002 (NRS-2002). Los servicios de hospitalización se agruparon en: servicios médicos, Cirugía General, Traumatología, otros servicios quirúrgicos y Oncología-Hematología. Se realizó un análisis estadístico de sensibilidad (S) y especificidad (Sp) y fueron comparados mediante curva COR. Resultados: Fueron valorados 201 pacientes con mediana de edad de 71,6 (RIC 21,4) años y el 51,2% fueron mujeres. La prevalencia de riesgo nutricional (RN) y desnutrición (DN) detectada fue: VSG 62,1%, MNA 68,6%, MUST 53,7% y NRS-2002 35,8%. Con todas las herramientas de cribado nutricional, excepto el MNA, se detectó una mayor prevalencia de RN y DN en los servicios médicos y quirúrgicos. En el análisis global el MNA obtuvo una S =93,3%, una Sp = 71,6% y un área bajo la curva COR de 0,825; el MUST obtuvo una S = 82,4%, una Sp = 93,4% y un área bajo la curva COR de 0,879; el NRS-2002 obtuvo una S = 56,0%, una Sp = 97,4% y un área bajo la curva COR de 0,766. Estos resultados fueron similares en el análisis por servicios de hospitalización. Conclusión: La herramienta de cribado nutricional recomendada en un centro hospitalario de tercer nivel y población envejecida sería el MUST por los adecuados resultados de sensibilidad y especificidad y la facilidad en su realización.

  4. The Value of the German Concept of Leadership Development and Civic Education - Innere Fuehrung - in Counterinsurgency Operations

    DTIC Science & Technology

    2009-01-01

    incorrect behavior, practice modem leadership, and thus get to know their soldiers.26 11 Civic Education Politische Bildung (civic education) is not...Unterricht verantwortliche Vorgesetzte darf die Behandlung politischer Fragen nicht auf die Darlegung einer einseitigen Meinung beschriinken. Das

  5. 77 FR 75612 - New England Fishery Management Council; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-21

    ... system, incorporation of monkfish into groundfish sectors and/or individually transferrable quotas (ITQs... establishing a monkfish DAS leasing program. The recommendations of the Advisory Panel will be forwarded to...

  6. Identification of a direct role for mitochondria in the toxicity of ribotoxic stress inducing trichothecenes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Trichothecenes are protein synthesis inhibitors that trigger a ribotoxic stress response leading to rapid activation of MAPKs, induction of proinflammatory responses, and cell death. These foodborne toxins include deoxynivalenol (DON), diacetoxyscirpenol (DAS), T-2, and trichothecin (Tcin). Identify...

  7. Security analysis and enhancements of an effective biometric-based remote user authentication scheme using smart cards.

    PubMed

    An, Younghwa

    2012-01-01

    Recently, many biometrics-based user authentication schemes using smart cards have been proposed to improve the security weaknesses in user authentication system. In 2011, Das proposed an efficient biometric-based remote user authentication scheme using smart cards that can provide strong authentication and mutual authentication. In this paper, we analyze the security of Das's authentication scheme, and we have shown that Das's authentication scheme is still insecure against the various attacks. Also, we proposed the enhanced scheme to remove these security problems of Das's authentication scheme, even if the secret information stored in the smart card is revealed to an attacker. As a result of security analysis, we can see that the enhanced scheme is secure against the user impersonation attack, the server masquerading attack, the password guessing attack, and the insider attack and provides mutual authentication between the user and the server.

  8. Instrumentation & Data Acquisition System (D AS) Engineer

    NASA Technical Reports Server (NTRS)

    Jackson, Markus Deon

    2015-01-01

    The primary job of an Instrumentation and Data Acquisition System (DAS) Engineer is to properly measure physical phenomenon of hardware using appropriate instrumentation and DAS equipment designed to record data during a specified test of the hardware. A DAS system includes a CPU or processor, a data storage device such as a hard drive, a data communication bus such as Universal Serial Bus, software to control the DAS system processes like calibrations, recording of data and processing of data. It also includes signal conditioning amplifiers, and certain sensors for specified measurements. My internship responsibilities have included testing and adjusting Pacific Instruments Model 9355 signal conditioning amplifiers, writing and performing checkout procedures, writing and performing calibration procedures while learning the basics of instrumentation.

  9. Aquatic Biological Inventory, Hartwell Drainage and Levee District, Greene County, Illinois

    DTIC Science & Technology

    1981-12-07

    1959); Hustedt (1930); Huber- Pestalozzi (1938) Cryptophyta Huber- Pestalozzi (1968) Euglenophyta Huber- Pestalozzi (1955) Chrysophyta Huber- Pestalozzi ...10 pp. () duber- Pestalozzi , G. 1938. Das Phytoplankton des Susswassers: Systematik and Biologie. Blaualgen, Bakter1.on. Die Binnengewasser. Band XVI

  10. Die Pugwash Conferences on Science and World Affairs Ein Beispiel für erfolgreiche „Track-II-Diplomacy“ der Naturwissenschaftler im Kalten Krieg

    NASA Astrophysics Data System (ADS)

    Neuneck, Götz

    "Kein Zeitalter der Geschichte ist stärker von den Naturwissenschaften durchdrungen und abhängiger von ihnen als das 20. Jahrhundert" schreibt Eric Hobsbawn im Kapitel "Zauberer und Lehrlinge: Die Naturwissenschaften" seines Buches "Zeitalter der Extreme".

  11. SARCOPTERYGII, Fleischflosser

    NASA Astrophysics Data System (ADS)

    Schultze, Hans-Peter

    Unter den rezenten und fossilen Fischen sind die Sarcopterygier durch fleischige Loben an den paarigen Flossen charakterisiert. Fossil gehen sie bis in das Obere Silur (vor 420 Mio. Jahren) zurück. Einige Gruppen (†Onychodontida, †Porolepiformes, †Elpistostegalia) waren auf das Devon beschränkt, andere verschwanden gegen Ende des Paläozoikums (†Rhizodontida, †Osteolepiformes). Nur wenige Arten der Dipnoi (Lungenfische) und Actinistia (Hohlstachler) haben überlebt; aus einer ausgestorbenen Teilgruppe evolvierten die erfolgreichen Tetrapoda. Im Devon waren die Sarcopterygier weltweit verbreitet; ihre rezenten fischartigen Formen sind dagegen auf die Südkontinente bzw. den Indischen Ozean beschränkt. Ursprünglich waren alle Formen marin. Mehrmals unabhängig wurde von ihnen das Süßwasser und innerhalb der Tetrapoden vor allem das Land erobert.

  12. A Variable Resolution Stretched Grid Data Assimilation System for Regional Studies and Applications

    NASA Technical Reports Server (NTRS)

    Fox-Rabinovitz, Michael S.; Takacs, Lawrence L.; Dee, Dick P.

    1999-01-01

    The variable resolution stretched grid (SG) version of the Goddard Earth Observing System (GEOS) Data Assimilation System (DAS) incorporating the GEOS SG-GCM, has been developed and tested. The area/region of interest used in experiments is a rectangle over the U.S. with -60 km horizontal resolution and 70 layers extending from the surface to 0.1 hPa. The forecast error statistics has been reassessed for finer regional resolution. The experiments are performed for winter and summer seasons. The SG-GCM and SG-DAS experiments show that a definite down-scaling takes place over the area of interest. The SG-DAS is capable of reproducing regional mesoscale patterns and diagnostics that are not produced by coarser uniform resolution runs. The SG-DAS fields and diagnostics are used for regional forecasting, new instrument impact studies, and for validation of regional climate simulation experiments.

  13. An overview and discussion of the Patient-Centered Outcomes Research Institute's decision aid portfolio.

    PubMed

    Gayer, Christopher C; Crowley, Matthew J; Lawrence, William F; Gierisch, Jennifer M; Gaglio, Bridget; Williams, John W; Myers, Evan R; Kendrick, Amy; Slutsky, Jean; Sanders, Gillian D

    2016-07-01

    Decision aids (DAs) help patients make informed healthcare decisions in a manner consistent with their values and preferences. Despite their promise, DAs developed with public research dollars are not being implemented and adopted in real-world patient care settings at a rate consistent with which they are being developed. To appraise the sum of the parts of the portfolio and create a strategic imperative surrounding future funding, the Patient-Centered Outcomes Research Institute (PCORI) tasked the Duke Evidence Synthesis Group with evaluating its DA portfolio. This paper describes PCORI's portfolio of DAs according to the Duke Evidence Synthesis Group's analysis in the context of PCORI's mission and the field of decision science. The results revealed a diversity within PCORI's portfolio of funded DA projects. Findings support the movement toward more rigorous DA development, assessment and maintenance. PCORI's funding priorities related to DAs are clarified and comparative questions of interest are posed.

  14. 50 CFR 648.92 - Effort-control program for monkfish limited access vessels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... fishing under a monkfish DAS, may fish any combination of monkfish, roundfish, and flatfish gillnets, up to 150 nets total, provided that the number of monkfish, roundfish, and flatfish gillnets...

  15. 50 CFR 648.92 - Effort-control program for monkfish limited access vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... fishing under a monkfish DAS, may fish any combination of monkfish, roundfish, and flatfish gillnets, up to 150 nets total, provided that the number of monkfish, roundfish, and flatfish gillnets...

  16. 50 CFR 648.92 - Effort-control program for monkfish limited access vessels.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... fishing under a monkfish DAS, may fish any combination of monkfish, roundfish, and flatfish gillnets, up to 150 nets total, provided that the number of monkfish, roundfish, and flatfish gillnets...

  17. Regional Studies and Applications with a Variable Resolution Stretched Grid Data Assimilation System

    NASA Technical Reports Server (NTRS)

    Fox-Rabinovitz, Michael; Dee, Dick; Takacs, Lawrence

    1999-01-01

    The variable resolution stretched grid (SG) version of the Goddard Earth Observing System (GEOS) Data Assimilation System (DAS) incorporating the GEOS SG-GCM, is used for regional analysis, forecast, and climate applications. The region of interest with enhanced horizontal resolution, mostly used in experiments, is a rectangle over the U.S. The SG-DAS is capable of reproducing regional mesoscale fields, patterns and diagnostics that are not produced by the medium uniform resolution run with the same amount of grid points as for the SG. The SG-DAS regional analyses and diagnostics are used for: validation of regional climate simulation experiments produced with the SG-GCM for the U.S. 1988 summer drought; and are planned to be used for atmospheric chemistry transport experiments. Also, a case study is conducted on a super-typhoon development in December 1997. The SG-DAS appears to be a viable candidate for a variety of regional studies and applications.

  18. AN INTRODUCTION TO ABHINAVA CHINTAMANI AN AYURVEDA TREATISE FROM ORISSA

    PubMed Central

    Kishore, Prem; Dash, S.; Nanda, M.C.

    1990-01-01

    A synopsis of the Sanskrit text, Abhinava Chintamani is presented in this paper. Attention is paid to highlight the novel features of this text composed in 18th Century A. D. by Mahamati Cakrapani Das of Orissa. PMID:22556512

  19. Nichtlineare Analyse von LC-TANK VCOs unter Berücksichtigung parasitärer Substrateffekte

    NASA Astrophysics Data System (ADS)

    Przytarski, J.; Bremer, J.-K.; Mathis, W.

    2009-05-01

    In dieser Arbeit wird ein Konzept vorgestellt, die Schaltungsarchitektur des LC-Tank-VCOs im höherdimensionalen Zustandsraum zu modellieren. Dabei wurde die VCO-Schaltung auf dominante nichtlineare und asymmetrische Effekte näher untersucht. Das entwickelte Modell bildet die Grundlage für nachfolgende parameterabhängige Analysen der Oszillatorschaltung mittels der Andronov-Hopf Bifurkationsanalyse. Zu diesem Zweck wurde ein höherdimensionales Modell entwickelt, welches für die Bifurkationsanalyse auf ein System 2. Ordnung reduziert werden muss. Als mathematisches Hilfsmittel zur Ordnungsreduktion des Systems wird das Verfahren der Zentrumsmannigfaltigkeit verwendet. Das Differentialgleichungssystem wird sehr schaltungsnah aufgestellt, daraus resultiert der Vorteil einer genaueren Repräsentation des physikalischen Verhaltens der Schaltung. Ziel ist es möglichst viele Effekte die sich auf das Verhalten des VCOs auswirken können, mit zu berücksichtigen.

  20. Comment on Faizal et al EPJC 76:30

    NASA Astrophysics Data System (ADS)

    Sidharth, B. G.

    2016-04-01

    In a recent paper in EPJC January 2016, Faizal, Khalil and Das have proposed time crystals with duration several orders of magnitude greater than Planck scale. We comment on this paper and shed further light on this aspect.

  1. 78 FR 70043 - Pesticide Product Registration; Receipt of an Application for a New Active Ingredient

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    ... name: DAS-81419-2 Soybean. Active ingredients: Bacillus thuringiensis Cry1Ac protein expressed in soybean and Bacillus thuringiensis Cry1F protein expressed in soybean. Proposed classification/Use:...

  2. Blut

    NASA Astrophysics Data System (ADS)

    Shah-Derler, Brigitte; Wintermantel, Erich; Ha, Suk-Woo

    Das Blut zirkuliert in einem System von Blutgefässen und erfüllt dabei wesentliche Transportaufgaben im Organismus. Hauptfunktionen des Blutes sind die Stoffversorgung und -entsorgung der Zellen (Sauerstoff, CO2, Nährstoffe, Stoffwechselprodukte, etc.), der Transport von Hormonen und die Regulation der Körpertemperatur. Das Blut besteht zu 40-45% aus zellulären Bestandteilen und zu 55-60% aus dem Blutplasma (Abb. 7.1). Die Gesamtmenge beträgt beim erwachsenen Menschen etwa 5 bis 6 Liter, was 7-8% des Körpergewichtes entspricht. Aufgrund seiner zahlreichen Aufgaben wird das Blut als "fliessendes Organ“ bezeichnet. Das Blutplasma besteht zu rund 90 Vol.% aus Wasser und zu 10 Vol.% aus Elektrolyten, gelösten Gasen, Proteinen (Albumine, Globuline) und Stoffwechselprodukten. Die annähernd gleichbleibende Zusammensetzung dieser Blutbestandteile gewährleistet u. a. einen relativ konstanten osmotischen Druck und pH-Wert.

  3. Zinc in diet

    MedlinePlus

    ... reduce your risk of becoming sick with the common cold. Starting to take zinc supplements within 24 hours ... 26. Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev . Jun18;6:CD001364. PMID: ...

  4. Real-time data acquisition system for the NASA Langley transonic dynamics tunnel

    NASA Technical Reports Server (NTRS)

    Cole, P. H.

    1979-01-01

    The hardware configuration of the Transonic Dynamics Wind Tunnel Data Acquisition System (DAS) which consists of an analog front end that can process up to 260 channels of data is presented. The DAS also has a multi-channel analog-to-digital subsystem that can process up to 50,000 samples of data per sec, and a digital computer with standard and nonstandard devices, with graphics capability. The software configuration of the DAS and complex hardware/software interfaces are described, which can provide automatic amplifier gain and offset adjustment for each data channel. Finally, a summary of specific DAS applications is given including the real-time processing of dynamic deflection data, unsteady pressure measurements, and flutter and buffet data.

  5. Genetics Home Reference: microcephaly-capillary malformation syndrome

    MedlinePlus

    ... A, Isidor B, David A, Smyser CD, Paciorkowski AR, Willing M, Woulfe J, Das S, Beaulieu CL, Marcadier ... Free article on PubMed Central Mirzaa GM, Paciorkowski AR, Smyser CD, Willing MC, Lind AC, Dobyns WB. ...

  6. Potential for Subsidence at the Low-Level Radioactive Waste Disposal Area

    SciTech Connect

    Keck, K.A.; Seitz, R.R.

    2002-09-26

    U.S. Department of Energy (DOE) Order 435.1, Radioactive Waste Management requires that DOE low-level radioactive waste (LLW) disposal facilities receive a Disposal Authorization Statement (DAS) from DOE-Headquarters. The DAS for the LLW disposal facility at the Radioactive Waste Management Complex (RWMC) at the Idaho National Engineering and Environmental Laboratory (INEEL) was granted in April 2000 and included a number of conditions that must be addressed. A maintenance plan (Schuman 2000) was prepared that identifies the tasks to be completed to address the conditions in the DAS as well as a schedule for their completion. The need for a subsidence analysis was one of the conditions identified for the DAS, and thus, a task to prepare a subsidence analysis was included in the maintenance plan. This document provides the information necessary to satisfy that requirement.

  7. Potential for Subsidence at the Low-level Waste Disposal Area

    SciTech Connect

    Keck, Karen Nina; Seitz, Roger Ray

    2002-09-01

    U.S. Department of Energy (DOE) Order 435.1, Radioactive Waste Management requires that DOE low-level radioactive waste (LLW) disposal facilities receive a Disposal Authorization Statement (DAS) from DOE-Headquarters. The DAS for the LLW disposal facility at the Radioactive Waste Management Complex (RWMC) at the Idaho National Engineering and Environmental Laboratory (INEEL) was granted in April 2000 and included a number of conditions that must be addressed. A maintenance plan (Schuman 2000) was prepared that identifies the tasks to be completed to address the conditions in the DAS as well as a schedule for their completion. The need for a subsidence analysis was one of the conditions identified for the DAS, and thus, a task to prepare a subsidence analysis was included in the maintenance plan. This document provides the information necessary to satisfy that requirement.

  8. Die Quantenwelt - unbestimmt und nichtlokal?: Interpretation verschränkter Zustände

    NASA Astrophysics Data System (ADS)

    Fink, Helmut

    2004-07-01

    Das aufblühende Gebiet der Quanteninformationsverarbeitung belebt die alte Frage, wie das Phänomen der quantenphysikalischen Verschränktheit zu interpretieren sei. Besonders das berühmte Gedankenexperiment von Einstein, Podolsky und Rosen rückt wieder in das Zentrum der Aufmerksamkeit, seit Laborexperimente an verschränkten Quantensystemen durchgeführt werden, deren Teile räumlich weit von einander entfernt sind. Kann ein Teil eines solchen verschränkten Systems mit Überlichtgeschwindigkeit spüren, dass an einem weit entfernten anderen Teil gemessen wird? Hinter dieser Frage steckt die Vorstellung, es gebe einen nichtlokalen Mechanismus in der Natur. Diese Vorstellung erweist sich jedoch als keineswegs zwingend und sogar als irreführend, wenn man akzeptiert, dass die Werte von Beobachtungsgrößen in Quantenzuständen objektiv unbestimmt sind. Sie entstehen erst dort, wo wirklich gemessen wird.

  9. The trigger and data acquisition for the NEMO-Phase 2 tower

    SciTech Connect

    Pellegrino, C.; Biagi, S.; Fusco, L. A.; Margiotta, A.; Spurio, M.; Chiarusi, T.; and others

    2014-11-18

    In the framework of the Phase 2 of the NEMO neutrino telescope project, a tower with 32 optical modules is being operated since march 2013. A new scalable Trigger and Data Acquisition System (TriDAS) has been developed and extensively tested with the data from this tower. Adopting the all-data-to-shore concept, the NEMO TriDAS is optimized to deal with a continuous data-stream from off-shore to on-shore with a large bandwidth. The TriDAS consists of four computing layers: (i) data aggregation of isochronal hits from all optical modules; (ii) data filtering by means of concurrent trigger algorithms; (iii) composition of the filtered events into post-trigger files; (iv) persistent data storage. The TriDAS implementation is reported together with a review of dedicated on-line monitoring tools.

  10. Tensoren und Felder

    NASA Astrophysics Data System (ADS)

    Dirschmid, Hans J.

    Das Lehrbuch soll Studierende mit Grundkenntnissen der Differential- und Integralrechnung in die klassische Feldtheorie mit modernen mathematischen Methoden einführen. Dementsprechend ist die Tensoranalysis das mathematische Thema, das Prinzip der Relativität das physikalische. Aus didaktischen Erwägungen gliedert sich der Text in zwei Teile. Um den Leser mit den Objekten vertraut zu machen, wird zunächst der affine und euklidische Raum zugrundegelegt, um verallgemeinernd zur Geometrie auf Mannigfaltigkeiten und Riemannschen Räumen überleiten zu können. Im Anschluß an die mathematische Theorie wird in die spezielle und allgemeine Relativitätstheorie eingeführt, wobei die Geometrie der Raum-Zeit, die Grundgesetze der Elektrodynamik und der Gravitation sowie Folgerungen zur Sprache kommen.

  11. 78 FR 77658 - New England Fishery Management Council; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... Oversight Committee and Advisory Panel will review the analyses provided by the Monkfish Plan Development Team for trips limits, including incidental catch limits, and DAS allocations for fishing years...

  12. 76 FR 60128 - Senior Executive Service; Legal Division Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-28

    ... (International Affairs); Peter A. Bieger, Deputy Assistant General Counsel (Banking and Finance); George Bostick, Benefits Tax Counsel; Michael Caballero, International Tax Counsel; Himamauli Das, Assistant General Counsel (International Affairs); Rochelle F. Granat, Assistant General Counsel (General Law, Ethics...

  13. Joint Confirmatory Factor Analysis of the Differential Ability Scales and the "Woodcock-Johnson Tests of Cognitive Abilities--Third Edition"

    ERIC Educational Resources Information Center

    Sanders, Sarah; McIntosh, David E.; Dunham, Mardis; Rothlisberg, Barbara A.; Finch, Holmes

    2007-01-01

    This study examined the underlying constructs measured by the "Differential Ability Scales" ("DAS"; C.D. Elliott, 1990a) as they relate to the "Cattell-Horn-Carroll (CHC) Theory" (K.S. McGrew, 1997) of cognitive abilities. The "DAS" and "Woodcock-Johnson Tests of Cognitive Abilities" ("WJ-III COG"; R.W.Woodcock, K.S. McGrew, & N. Mather, 2001)…

  14. Umsetzung der Unternehmensstrategie mit der Balanced Scorecard

    NASA Astrophysics Data System (ADS)

    Crespo, Isabel; Bergmann, Lars; Portmann, Stefan; Lacker, Thomas; Lacker, Michael; Fleischmann, Jürgen; Kozó, Hans

    Die Balanced Scorecard (BSC) ist ein Ansatz zum strategischen Management, der neben der Ausrichtung des Unternehmens auf finanzielle Zielwerte ebenso großes Gewicht auf so genannte weiche Faktoren legt, die den wirtschaftlichen Erfolg eines Unternehmens erst ermöglichen. Das entscheidende Merkmal der Balanced Scorecard ist dabei, dass sie ein ausgewogenes System strategischer Ziele herstellt, welches das Unternehmen hinsichtlich der vier Perspektiven Finanzen, Kunden, interne Prozesse und Mitarbeiter und Potenziale strategisch ausrichtet (Kaplan u. Norton 1997).

  15. 25 Jahre - Institut fuer Geodaesie, Teil 1: Wissenschaftliche Beitraege und Berichte (25 Years - Institute of Geodesy, Part 1: Scientific Contributions and Reports)

    DTIC Science & Technology

    2000-01-01

    des Dispersionswinkels zur Bestimmung der Refraktion. AVN 100, S. 51-62, 1993 HAMMING, R., W.: Digitale Filter. VCH-Verlag, Weinheim 1987 HAMPEL, F...KRONMOLLER, H.: Digitale Signalverarbeitung. Springer-Verlag, Berlin 1991 KUHLMANN, H.: Ein Beitrag zur Oberwachung von Briickenbauwerken mit...1987), das Europdische Referenzsystem - EUREF (SEEGER/ALTINER/ENGELHARDT/FRANKE/HABRICH/SCHLC- TER 1998) und das Sistema di Referencia del America del

  16. Development and application of patient decision aids.

    PubMed

    Bae, Jong-Myon

    2015-01-01

    With the current overdiagnosis of thyroid cancer resulting from routine screening in Korea, it is necessary to educate the public that not all cancers are malignant. The exposure to patient decision aids (PtDAs) compared to usual care reduced the number of people choosing to undergo prostate-specific antigen screening. This article introduces the definition, usefulness, and developmental processes of PtDAs and suggests the urgent need for a Korean PtDA related to thyroid cancer screening.

  17. Experimental Investigation of Atmospheric Response to the Total Solar Eclipse of 26 February 1979. Conduct of Field Measurements. Phase III.

    DTIC Science & Technology

    1979-04-18

    Vehicle: Super Loki Principal Investigator: Mr. Frank Schmidlin DAS NASA/Wallops Flight Center Wallops Island, Virginia 23337 (804) 824-3411 Sponsors...Rocket Nos: CMSL-09, 10 Launch Vehicle: Super Loki Principal Investigator: Mr. Frank Schmidlin DAS NASA/Wallops Flight Center Wallops Island, Virginia...Figure 4.6 and 4.7. 4.1.5 McMarmac Launch Site The Super Arcas launcher (A) and the Super Loki launcher (E) were installed in September 1978. The

  18. Diet, Stem Cells, and Breast Cancer Prevention

    DTIC Science & Technology

    2011-01-01

    mammary epithelial cells, where breast cancer arises. In particular, curcumin from turmeric [37], resveratrol from grape [38], capsaicin from chili...diseases. Int J Biochem Cell Biol 2009;41:40–59. [38] Das S, Das DK. Anti-inflammatory responses of resveratrol . Inflamm Allergy Drug Targets 2007;6:168–73...and genomic consequences on mammary epithelial cells, where breast cancer arises. In particular, curcumin from turmeric [37], resveratrol from grape

  19. Big brother - a fully automated control system for the DELPHI experiment

    SciTech Connect

    Franek, B.; Sekulin, R.; Doenszelmann, M.; Gasper, C.; Charpentier, Jonker, M.

    1994-12-31

    The integrated control system of the DELPHI experiment is described. It allows the data to be taken in an almost automatic fashion. This is achieved by computer monitoring of the states of the LEP machine, the DELPHI subdetectors (SC) and the Data Acquisition System (DAS). Depending on these states, computer initiated actions are then taken. It has been designed using {open_quote}State Manager{close_quote} concept already used for local and central controls of DAS and SC.

  20. Performance Comparison of Top and Bottom Contact Gallium Arsenide (GaAs) Solar Cell

    DTIC Science & Technology

    2014-09-01

    Performance Comparison of Top and Bottom Contact Gallium Arsenide (GaAs) Solar Cell by Naresh C Das ARL-TR-7054 September 2014...September 2014 Performance Comparison of Top and Bottom Contact Gallium Arsenide (GaAs) Solar Cell Naresh C Das Sensors and Electron...From - To) 01/02/2014–07/15/2014 4. TITLE AND SUBTITLE Performance Comparison of Top and Bottom Contact Gallium Arsenide (GaAs) Solar Cell 5a

  1. Wege in die Zukunft

    NASA Astrophysics Data System (ADS)

    Kauermann, Göran; Mosler, Karl

    Die Zukunft stellt große Herausforderungen an die Arbeit der Deutschen Statistischen Gesellschaft. Sie betreffen die gestiegenen Anforderungen der Nutzer von Statistik, die Kommunikationsmöglichkeiten des Internets sowie die Dynamik der statistischen Wissenschaften und ihrer Anwendungsgebiete. Das Kapitel 5 beschreibt, wie sich die Gesellschaft diesen Herausforderungen stellt und welche Ziele sie sich in der wissenschaftlichen Zusammenarbeit und im Kampf gegen das Innumeratentum gesetzt hat.

  2. Improvements to NASA's Debris Assessment Software

    NASA Technical Reports Server (NTRS)

    Opiela, J.; Johnson, Nicholas L.

    2007-01-01

    NASA's Debris Assessment Software (DAS) has been substantially revised and expanded. DAS is designed to assist NASA programs in performing orbital debris assessments, as described in NASA s Guidelines and Assessment Procedures for Limiting Orbital Debris. The extensive upgrade of DAS was undertaken to reflect changes in the debris mitigation guidelines, to incorporate recommendations from DAS users, and to take advantage of recent software capabilities for greater user utility. DAS 2.0 includes an updated environment model and enhanced orbital propagators and reentry-survivability models. The ORDEM96 debris environment model has been replaced by ORDEM2000 in DAS 2.0, which is also designed to accept anticipated revisions to the environment definition. Numerous upgrades have also been applied to the assessment of human casualty potential due to reentering debris. Routines derived from the Object Reentry Survival Analysis Tool, Version 6 (ORSAT 6), determine which objects are assessed to survive reentry, and the resulting risk of human casualty is calculated directly based upon the orbital inclination and a future world population database. When evaluating reentry risks, the user may enter up to 200 unique hardware components for each launched object, in up to four nested levels. This last feature allows the software to more accurately model components that are exposed below the initial breakup altitude. The new DAS 2.0 provides an updated set of tools for users to assess their mission s compliance with the NASA Safety Standard and does so with a clear and easy-to-understand interface. The new native Microsoft Windows graphical user interface (GUI) is a vast improvement over the previous DOS-based interface. In the new version, functions are more-clearly laid out, and the GUI includes the standard Windows-style Help functions. The underlying routines within the DAS code are also improved.

  3. Development and operation of a real-time data acquisition system for the NASA, Langley Research Center Differential Absorption Lidar

    NASA Technical Reports Server (NTRS)

    Butler, C.; Kindle, E. C.

    1984-01-01

    The capabilities of the DIAL data acquisition system (DAS) for the remote measurement of atmospheric trace gas concentrations from ground and aircraft platforms were extended through the purchase and integration of other hardware and the implementation of improved software. An operational manual for the current system is presented. Hardware and peripheral device registers are outlined only as an aid in debugging any DAS problems which may arise.

  4. Plasma Membrane Aquaporins Play a Significant Role during Recovery from Water Deficit1

    PubMed Central

    Martre, Pierre; Morillon, Raphaël; Barrieu, François; North, Gretchen B.; Nobel, Park S.; Chrispeels, Maarten J.

    2002-01-01

    The role of plasma membrane aquaporins (PIPs) in water relations of Arabidopsis was studied by examining plants with reduced expression of PIP1 and PIP2 aquaporins, produced by crossing two different antisense lines. Compared with controls, the double antisense (dAS) plants had reduced amounts of PIP1 and PIP2 aquaporins, and the osmotic hydraulic conductivity of isolated root and leaf protoplasts was reduced 5- to 30-fold. The dAS plants had a 3-fold decrease in the root hydraulic conductivity expressed on a root dry mass basis, but a compensating 2.5-fold increase in the root to leaf dry mass ratio. The leaf hydraulic conductance expressed on a leaf area basis was similar for the dAS compared with the control plants. As a result, the hydraulic conductance of the whole plant was unchanged. Under sufficient and under water-deficient conditions, stomatal conductance, transpiration rate, plant hydraulic conductance, leaf water potential, osmotic pressure, and turgor pressure were similar for the dAS compared with the control plants. However, after 4 d of rewatering following 8 d of drying, the control plants recovered their hydraulic conductance and their transpiration rates faster than the dAS plants. Moreover, after rewatering, the leaf water potential was significantly higher for the control than for the dAS plants. From these results, we conclude that the PIPs play an important role in the recovery of Arabidopsis from the water-deficient condition. PMID:12481094

  5. Waste retrieval sluicing system data acquisition system acceptance test report

    SciTech Connect

    Bevins, R.R.

    1998-07-31

    This document describes the test procedure for the Project W-320 Tank C-106 Sluicing Data Acquisition System (W-320 DAS). The Software Test portion will test items identified in the WRSS DAS System Description (SD), HNF-2115. Traceability to HNF-2115 will be via a reference that follows in parenthesis, after the test section title. The Field Test portion will test sensor operability, analog to digital conversion, and alarm setpoints for field instrumentation. The W-320 DAS supplies data to assist thermal modeling of tanks 241-C-106 and 241-AY-102. It is designed to be a central repository for information from sources that would otherwise have to be read, recorded, and integrated manually. Thus, completion of the DAS requires communication with several different data collection devices and output to a usable PC data formats. This test procedure will demonstrate that the DAS functions as required by the project requirements stated in Section 3 of the W-320 DAS System Description, HNF-2115.

  6. Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

    PubMed Central

    Bluett, J; Ibrahim, I; Plant, D; Hyrich, K L; Morgan, A W; Wilson, A G; Isaacs, J D; Gaston, H; Mulherin, D; Price, T; Sheeran, T; Chalam, V; Baskar, S; Emery, P; Morgan, A; Buch, M; Bingham, S; O'Reilly, S; Badcock, L; Regan, M; Ding, T; Deighton, C; Summers, G; Raj, N; Stevens, R; Williams, N; Isaacs, J; Platt, P; Walker, D; Kay, L; Griffiths, B; Ng, W-F; Peterson, P; Lorenzi, A; Foster, H; Friswell, M; Thompson, B; Lee, M; Griffiths, I; Hassell, A; Dawes, P; Dowson, C; Kamath, S; Packham, J; Shadforth, M; Brownfield, Ann; Williams, R; Mukhtyar, C; Harrison, B; Snowden, N; Naz, S; Ledingham, J; Hull, R; McCrae, F; Thomas, A; Min, S Young; Shaban, R; Wong, E; Kelly, C; Heycock, C; Hamilton, J; Saravanan, V; Wilson, G; Bax, D; Dunkley, L; Akil, M; Tattersall, R; Kilding, R; Till, S; Boulton, J; Tait, T; Bukhari, M; Halsey, J; Ottewell, L; Buckley, C; Situnayake, D; Carruthers, D; Grindulis, K; Khatack, F; Elamanchi, S; Raza, K; Filer, A; Jubb, R; Abernathy, R; Plant, M; Pathare, S; Clarke, F; Tuck, S; Fordham, J; Paul, A; Bridges, M; Hakim, A; O'Reilly, D; Rajagopal, V; Bhagat, S; Edwards, C; Prouse, P; Moitra, R; Shawe, D; Bamji, A; Klimiuk, P; Bowden, A; Mitchell, W; Bruce, I; Barton, A; Gorodkin, R; Ho, P; Hyrich, K; Dixon, W; Rai, A; Kitas, G; Erb, N; Klocke, R; Douglas, K; Pace, A; Sandhu, R; Whallett, A; Birrell, F; Allen, M; Chaudhuri, K; Chattopadhyay, C; McHale, J; Jones, A; Gupta, A; Pande, I; Gaywood, I; Lanyon, P; Courtney, P; Doherty, M; Chinoy, H; O'Neill, T; Herrick, A; Jones, A; Cooper, R; Bucknall, R; Marguerie, C; Rigby, S; Dunn, N; Green, S; Al-Ansari, A; Webber, S; Hopkinson, N; Dunne, C; Quilty, B; Szebenyi, B; Green, M; Quinn, M; Isdale, A; Brown, A; Saleem, B; Samanta, A; Sheldon, P; Hassan, W; Francis, J; Kinder, A; Neame, R; Moorthy, A; Al-Allaf, W; Taggart, A; Fairburn, K; McKenna, F; Green, M; Gough, A; Lawson, C; Piper, M; Korendowych, E; Jenkinson, T; Sengupta, R; Bhalla, A; McHugh, N; Bond, Debbie; Luqmani, R; Bowness, B; Wordsworth, P; David, J; Smith, W; Mewar, D; Tunn, E; Nelson, K; Kennedy, T; Nixon, J; Woolf, A; Davis, M; Hutchinson, D; Endean, A; Coady, D; Wright, D; Morley, C; Raftery, G; Bracewell, C; Kidd, L; Abbas, I; Filer, C; Kallarackal, G; Barton, A

    2014-01-01

    Eligibility for anti-tumour necrosis factor (TNF) therapy in most European countries is restricted to severe, active rheumatoid arthritis (RA). The DAS28 score is a marker of disease severity and incorporates one of two inflammatory markers, erythrocyte sedimentation rate (ESR) or C-reactive protein. We aimed to determine the relation between genetic variants known to affect ESR and levels of ESR in patients with active RA. DNA samples were genotyped for four single-nucleotide polymorphisms (SNPs) rs7527798 (CR1L), rs6691117 (CR1), rs10903129 (TMEM57) and rs1043879 (C1orf63). The association between SNPs and baseline ESR, baseline DAS28-ESR, and change in DAS28-ESR was evaluated. Baseline ESR was significantly associated with CR1 rs6691117 genotype (P=0.01). No correlation was identified between baseline DAS28-ESR or change in DAS28-ESR. In conclusion, genetic variation in the gene encoding CR1 may alter ESR levels but not DAS28-ESR, indicating no adjustment for CR1 genotype is required in the assessment of patients with severe active RA. PMID:23856853

  7. Assessment of apathy independent of physical disability: validation of the Dimensional Apathy Scale in Italian healthy sample.

    PubMed

    Santangelo, Gabriella; Raimo, Simona; Siciliano, Mattia; D'Iorio, Alfonsina; Piscopo, Fausta; Cuoco, Sofia; Bottone, Marianna; Trojsi, Francesca; Grossi, Dario; Trojano, Luigi

    2017-02-01

    Apathy is well described in neurodegenerative diseases characterized by motor disability; therefore, assessment of apathy avoiding possible confounding effects of motor impairments is necessary in neurological diseases. Recently, the Dimensional Apathy Scale (DAS) was developed to assess apathy as multifaceted construct, independent of physical disability. We developed the Italian version of the Dimensional Apathy Scale (I-DAS) and explored its psychometric properties in a sample of 309 healthy individuals. Participants also completed Apathy Evaluation Scale, Beck Depression Inventory-II and Addenbrooke's Cognitive Examination-Revised. The I-DAS showed high internal consistency, good convergent and divergent validity. The I-DAS had a three-factor structure, such as the original scale. The I-DAS scored was significantly correlated with individuals' education, but not with age or gender. We, therefore, computed correction factor for education and provided percentile distribution of the adjusted scores to identify individuals with high levels of apathy. The I-DAS showed good psychometric properties and can be a valid and reliable tool to assess multidimensional apathy.

  8. Engineering Pichia pastoris for improved NADH regeneration: A novel chassis strain for whole-cell catalysis

    PubMed Central

    Geier, Martina; Brandner, Christoph; Strohmeier, Gernot A; Hall, Mélanie; Hartner, Franz S

    2015-01-01

    Summary Many synthetically useful reactions are catalyzed by cofactor-dependent enzymes. As cofactors represent a major cost factor, methods for efficient cofactor regeneration are required especially for large-scale synthetic applications. In order to generate a novel and efficient host chassis for bioreductions, we engineered the methanol utilization pathway of Pichia pastoris for improved NADH regeneration. By deleting the genes coding for dihydroxyacetone synthase isoform 1 and 2 (DAS1 and DAS2), NADH regeneration via methanol oxidation (dissimilation) was increased significantly. The resulting Δdas1 Δdas2 strain performed better in butanediol dehydrogenase (BDH1) based whole-cell conversions. While the BDH1 catalyzed acetoin reduction stopped after 2 h reaching ~50% substrate conversion when performed in the wild type strain, full conversion after 6 h was obtained by employing the knock-out strain. These results suggest that the P. pastoris Δdas1 Δdas2 strain is capable of supplying the actual biocatalyst with the cofactor over a longer reaction period without the over-expression of an additional cofactor regeneration system. Thus, focusing the intrinsic carbon flux of this methylotrophic yeast on methanol oxidation to CO2 represents an efficient and easy-to-use strategy for NADH-dependent whole-cell conversions. At the same time methanol serves as co-solvent, inductor for catalyst and cofactor regeneration pathway expression and source of energy. PMID:26664594

  9. Advances and applications of dynamic-angle spinning nuclear magnetic resonance

    SciTech Connect

    Baltisberger, Jay Harvey

    1993-06-01

    This dissertation describes nuclear magnetic resonance experiments and theory which have been developed to study quadrupolar nuclei (those nuclei with spin greater than one-half) in the solid state. Primarily, the technique of dynamic-angle spinning (DAS) is extensively reviewed and expanded upon in this thesis. Specifically, the improvement in both the resolution (two-dimensional pure-absorptive phase methods and DAS angle choice) and sensitivity (pulse-sequence development), along with effective spinning speed enhancement (again through choice of DAS conditions or alternative multiple pulse schemes) of dynamic-angle spinning experiment was realized with both theory and experimental examples. The application of DAS to new types of nuclei (specifically the {sup 87}Rb and {sup 85}Rb nuclear spins) and materials (specifically amorphous solids) has also greatly expanded the possibilities of the use of DAS to study a larger range of materials. This dissertation is meant to demonstrate both recent advances and applications of the DAS technique, and by no means represents a comprehensive study of any particular chemical problem.

  10. Updating annotations with the distributed annotation system and the automated sequence annotation pipeline

    PubMed Central

    Speier, William; Ochs, Michael F.

    2012-01-01

    Summary: The integration between BioDAS ProServer and Automated Sequence Annotation Pipeline (ASAP) provides an interface for querying diverse annotation sources, chaining and linking results, and standardizing the output using the Distributed Annotation System (DAS) protocol. This interface allows pipeline plans in ASAP to be integrated into any system using HTTP and also allows the information returned by ASAP to be included in the DAS registry for use in any DAS-aware system. Three example implementations have been developed: the first accesses TRANSFAC information to automatically create gene sets for the Coordinated Gene Activity in Pattern Sets (CoGAPS) algorithm; the second integrates annotations from multiple array platforms and provides unified annotations in an R environment; and the third wraps the UniProt database for integration with the SPICE DAS client. Availability: Source code for ASAP 2.7 and the DAS 1.6 interface is available under the GNU public license. Proserver 2.20 is free software available from SourceForge. Scripts for installation and configuration on Linux are provided at our website: http://www.rits.onc.jhmi.edu/dbb/custom/A6/ Contact: Speier@mii.ucla.edu or mfo@jhu.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:22945787

  11. Protective Effects of Diallyl Sulfide on Ovalbumin-Induced Pulmonary Inflammation of Allergic Asthma Mice by MicroRNA-144, -34a, and -34b/c-Modulated Nrf2 Activation.

    PubMed

    Ho, Cheng-Ying; Lu, Chi-Cheng; Weng, Chia-Jui; Yen, Gow-Chin

    2016-01-13

    Allergic airway disorder is characterized by an increase in the level of reactive oxygen species (ROS). The induction of inflammation and hyperresponsiveness by an allergen was ameliorated by antioxidants in vivo. This study investigated the protective effects and underlying mechanism of diallyl sulfide (DAS) on ovalbumin (OVA)-induced allergic asthma of BALB/c mice. The animals were intraperitoneally sensitized by inhaling OVA to induce chronic airway inflammation. By administering DAS, a decrease of the infiltrated inflammatory cell counts and the levels of IL-4 and IL-10 in bronchoalveolar lavage fluid as well as the OVA-specific immunoglobulin E levels in sera were observed. DAS also effectively inhibited OVA-induced inflammatory cell infiltration and mucus hypersecretion in lung tissue. Several OVA-induced inflammatory factors (ROS, 8-hydroxy-2'-deoxyguanosine, 8-iso-prostaglandin F2α, and NF-κB) were inhibited by DAS. In addition, DAS increased OVA inhalation-reduced levels of Nrf2 activation by regulating microRNA-144, -34a and -34b/c. Together, the pathogenesis of OVA-induced asthma is highly associated with oxidative stress, and DAS may be an effective supplement to alleviate this disease.

  12. Pharmacokinetics of danaparoid sodium, dalteparin sodium and heparin determined by inhibitory effect on the activated coagulation factor X activity after single intravenous administration in rabbits.

    PubMed

    Ishida, M; Nakada, Y; Horiuchi, M; Sakamoto, F

    1998-08-01

    The inhibitory effect on the activated coagulation factor X activity (anti-Xa activity) in plasma and urine of danaparoid sodium (DAS, CAS 9005-49-6) was compared with that of dalteparin sodium (DLS, CAS 9041-08-1) and heparin (CAS 9005-49-6) after single intravenous administration at a dose of 640 anti-Xa U/kg to male rabbits. The elimination of half-life of DAS was 9.90 h and was 6.0 times longer than that of DLS and 16.5 times longer than that of heparin. The area under the plasma concentration-time curve (AUC) of DAS was 47.13 +/- 14.55 anti-Xa U.h/ml and was 2.4 times larger than that of DLS and 2.9 times larger than that of heparin. The urinary cumulative excretion of anti-Xa activity of DAS and DLS was 42.6 +/- 6.4% and 16.4 +/- 0.8% of dose, respectively, in 24 h after dosing, respectively. But the anti-Xa activity in urine was not detected at any sampling points after administration of heparin. DAS has a longer elimination half-life and a higher renal excretion of anti-Xa activity than that of DLS and heparin. Therefore, in comparison to DLS and heparin, it seems that the anticoagulant activity of DAS has a long duration.

  13. Modeling the World Health Organization Disability Assessment Schedule II using non-parametric item response models.

    PubMed

    Galindo-Garre, Francisca; Hidalgo, María Dolores; Guilera, Georgina; Pino, Oscar; Rojo, J Emilio; Gómez-Benito, Juana

    2015-03-01

    The World Health Organization Disability Assessment Schedule II (WHO-DAS II) is a multidimensional instrument developed for measuring disability. It comprises six domains (getting around, self-care, getting along with others, life activities and participation in society). The main purpose of this paper is the evaluation of the psychometric properties for each domain of the WHO-DAS II with parametric and non-parametric Item Response Theory (IRT) models. A secondary objective is to assess whether the WHO-DAS II items within each domain form a hierarchy of invariantly ordered severity indicators of disability. A sample of 352 patients with a schizophrenia spectrum disorder is used in this study. The 36 items WHO-DAS II was administered during the consultation. Partial Credit and Mokken scale models are used to study the psychometric properties of the questionnaire. The psychometric properties of the WHO-DAS II scale are satisfactory for all the domains. However, we identify a few items that do not discriminate satisfactorily between different levels of disability and cannot be invariantly ordered in the scale. In conclusion the WHO-DAS II can be used to assess overall disability in patients with schizophrenia, but some domains are too general to assess functionality in these patients because they contain items that are not applicable to this pathology.

  14. The effect on treatment response of fibromyalgic symptoms in early rheumatoid arthritis patients: results from the ESPOIR cohort

    PubMed Central

    Combe, Bernard; Niu, Jingbo; Rincheval, Nathalie; Gaujoux-Viala, Cécile; Felson, David T.

    2015-01-01

    Objective. To evaluate whether patients with RA who belong to the spectrum of fibromyalgic RA (FRA) have an impaired response to treatment measured by traditional activity scores. Methods. Patients from the ESPOIR cohort were analysed. This prospective cohort included 813 patients with early arthritis not initially receiving DMARDs. Among the 697 patients who met RA classification criteria, we studied two groups, one with and the other without FRA. The following endpoints were compared at 6, 12 and 18 months using a mixed linear regression model: 28-joint DAS (DAS28), Simple Disease Activity Index (SDAI), Clinical Disease Activity Index (CDAI) and HAQ. In addition, attainment of low disease activity (LDA; DAS28 <3.2) and remission (DAS28 <2.6, SDAI <3.3, CDAI <2.8) at these time points was analysed. Results. Patients with FRA (n = 120) had higher DAS28, SDAI, CDAI and HAQ scores than patients with RA and no fibromyalgic characteristics (n = 548). DAS28 and other DASs started out higher in subjects with FRA, and while they improved to a similar extent to in the isolated RA group, they remained consistently higher among FRA patients. Achievement of LDA and remission was significantly less likely in subjects with FRA. Conclusion. Patients with FRA and RA will have a similar response to treatment according to the decrease in indexes of disease activity, but may miss the target of remission or LDA. PMID:26175470

  15. EEG epoch selection: lack of alpha rhythm improves discrimination of Alzheimer's disease.

    PubMed

    Fraga, Francisco J; Oliveira, Eliezyer F; Kanda, Paulo A M

    2016-08-01

    In this work we propose a detailed EEG epoch selection method and compare epochs with rare and abundant alpha rhythm (AR) of patients with Alzheimer's disease (AD) and normal controls. Epochs were classified as Dominant Alpha Scenario (DAS) and Rare Alpha Scenario (RAS) according to the AR percentage (energy within the 8-13 Hz bandwidth) in O1, O2 and Oz electrodes. Participants were divided into four groups: 17 DAS controls (N1), 15 DAS mild-AD patients (AD1), 12 RAS controls (N2) and 15 RAS mild-AD patients (AD2). We found out that scenario factor (DAS vs. RAS, two-way ANOVA) is significant over a great amount of electrode-bandwidth situations. Furthermore, one-way ANOVA showed significant differences between RAS AD and RAS controls in much more situations as compared to DAS. This is the first study using AD awake EEG reporting the decisive influence of alpha rhythm on epoch selection, where our results revealed that, contrary to what was initially expected, EEG epochs with poor alpha (RAS) discriminate mild AD much better than those presenting richer alpha content (DAS).

  16. Drugs of abuse in urban groundwater. A case study: Barcelona.

    NASA Astrophysics Data System (ADS)

    Jurado, A.; Mastroianni, N.; Vazquez-Suñe, E.; Carrera, J.; Tubau, I.; Pujades, E.; Postigo, C.; Lopez de Alda, M.; Barceló, D.

    2012-04-01

    This study is concerned with drugs of abuse (DAs) and their metabolites in urban groundwater at field scale in relation to (1) the spatial distribution of the groundwater samples, (2) the depth of the groundwater sample, (3) the presence of DAs in recharge sources, and (4) the identification of processes affecting the fate of DAs in groundwater. To this end, urban groundwater samples were collected in the city of Barcelona and a total of 21 drugs were analyzed including cocainics, amphetamine-like compounds, opioids, lysergics and cannabinoids and the prescribed drugs benzodiazepines. Overall, the highest groundwater concentrations and the largest number of detected DAs were found in zones basically recharged by a river that receives large amounts of effluents from waste water treatment plants (WWTPs). In contrast, the urbanized areas yielded not only lower concentrations but also a much smaller number of drugs, which suggests a local origin. In fact, cocaine and its metabolite were dominant in more prosperous neighbourhoods, whereas the cheaper (MDMA) was the dominant DA in poorer districts. Concentrations of DAs estimated mainly from the waste water fraction in groundwater samples were consistently higher than the measured ones, suggesting that DAs undergo removal processes in both reducing and oxidizing conditions.

  17. [Myxoid liposarcoma of the anterior mediastinum. A case report and bibliography review].

    PubMed

    Luna-Martínez, Javier; Molina-Ramírez, Daniel; Mata-Quintero, Carlos Javier; García-Arrona, Luis Roberto; Peña-Rosas, Diana Pérez; Mondragón-Pinzón, Erwin Eduardo

    2014-01-01

    Antecedentes: la incidencia de sarcomas de tejidos blandos es de 1.8 a 5 casos por año; 50% aparecen en las extremidades, 40% en el tronco y retroperitoneo. Los liposarcomas primarios de mediastino representan menos de 1% de los tumores mediastinales. Caso clínico: paciente femenina de 53 años de edad, originaria y residente de Tabasco, con antecedente de liposarcoma pleomórfico de mediastino anterior (durante su tercer embarazo) 16 años antes de su ingreso actual; fue tratada en el Instituto Nacional de Cancerología con resección y radioterapia. Acudió a su unidad de adscripción por dolor torácico, tos y expectoración hialina, la trataron como neumonía. Después se agregó disnea de medianos esfuerzos, y edema de miembros pélvicos; con la tomografía computada de tórax se diagnosticó un tumor mediastinal delimitado de 9 × 9 cm; la enviaron a nuestra unidad para su resección. Conclusiones: los liposarcomas representan menos de 1% de los tumores del mediastino, y requieren seguimiento a largo plazo por su alta recidiva después de un largo periodo libre de enfermedad.

  18. [Validation of an adverse event reporting system in primary care].

    PubMed

    de Lourdes Rojas-Armadillo, María; Jiménez-Báez, María Valeria; Chávez-Hernández, María Margarita; González-Fondón, Araceli

    2016-01-01

    Introducción: la seguridad del paciente es un tema prioritario en los sistemas de salud por el gasto que genera, el desgaste institucional, la falta de credibilidad y la frustración del personal que comete los eventos adversos. No existe un instrumento estandarizado y sistemático para registrar, reportar y analizar los eventos adversos en unidades de atención primaria. El objetivo fue validar un sistema de vigilancia para el registro de eventos centinelas, adversos y cuasi fallas en atención primaria. Métodos: se revisaron sistemas de registro y notificación de eventos adversos en atención primaria. Asimismo, se diseñó una propuesta de instrumento para el registro en unidades de atención primaria en el Instituto Mexicano del Seguro Social que integrara fallas en la estructura y en el proceso. Resultados: se le presentó el caso del formato VENCER-MF a 35 sujetos. El 100 % identificó una falla en el proceso de atención médica, 90 % registró un evento centinela, 85 % identificó el origen de este y el 75 % sugirió medidas para evitar la recurrencia de eventos adversos. Se obtuvo un alfa de Cronbach de 0.6, con una p = 0.03. Conclusión: el instrumento VENCER-MF tiene una consistencia buena para la identificación de eventos adversos.

  19. [Study of serum albumin and BMI as nutritional markers in hemodialysis patients].

    PubMed

    Quero Alfonso, Angel I; Fernández Castillo, Rafael; Fernández Gallegos, Ruth; Gomez Jimenez, Francisco Javier

    2014-10-03

    Introducción: La malnutrición proteíco calorica asi como la inflamación sistémica y metabólica son trastornos frecuentes entre los pacientes con insuficiencia renal crónica sometidos a tratamiento renal sustitutivo (Hemodiálisis), lo que contribuye a su morbilidad y mortalidad. Objetivos: El objetivo de este trabajo fue evaluar el estado nutricional de los pacientes de una unidad de hemodiálisis mediante la valoración de parámetros bioquímicos nutricionales como la albúmina, y parámetros antropométricos de índice de masa corporal durante diez años de seguimiento. Métodos: En este trabajo se ha seguido a 90 pacientes de ambos sexos con insuficiencia renal crónica que fueron tratados con hemodiálisis periódicamente en nuestra unidad durante diez años. A todos los pacientes se le realizaron mediciones trimestrales de albúmina plasmática (Alb), y otras determinaciones bioquimicas, y se les efectuaron mediciones antropométricas de peso, altura e índice de masa corporal calculado mediante la formula peso/talla², agrupada enIMC < 23 kg/m2 y niveles de albumina.

  20. [Causal analysis and impact of a systematic error detected about consumption associated with trastuzumab].

    PubMed

    Bujaldón Querejeta, Nuria; Camacho Romera, Dolores; Pomares Pastor, José Antonio; Sánchez Garnes, María; Martínez Ramírez, Mauricio; González Delgado, Mercedes

    2015-09-01

    Objetivo: determinar la causa de la diferencia constante entre las unidades teóricas de trastuzumab consumidas y las reales en una unidad de mezclas intravenosas. Métodos: se realizó un estudio del procedimiento completo manual y electrónico de la preparación de mezclas con trastuzumab mediante observación visual y revisión de los datos de control cuantitativo proporcionados por el sistema electrónico de preparación asistida y segura de la aplicación Farmis-Oncofarm ®. Resultados: se encontró diferencia entre el volumen óptimo del vial de trastuzumab que informa la ficha técnica del producto y el contenido en la ficha del medicamento de la aplicación. Además se encontró un defecto del volumen óptimo de las jeringas de 10 ml utilizadas en el proceso de reconstitución del vial. Conclusiones: el defecto de volumen óptimo de las jeringas de 10 ml utilizadas en el proceso de reconstitución es la causa del mayor número de viales reales consumidos en la preparación de mezclas con trastuzumab. Esto produce un impacto económico muy importante, estimando un sobrecoste anual de aproximadamente 46.508 €, sin provocar consecuencias negativas en el paciente.