Science.gov

Sample records for establishing guidance levels

  1. A pilot study exploring the possibility of establishing guidance levels in x-ray directed interventional procedures

    SciTech Connect

    Balter, S.; Miller, D. L.; Vano, E.; Ortiz Lopez, P.; Bernardi, G.; Cotelo, E.; Faulkner, K.; Nowotny, R.; Padovani, R.; Ramirez, A.

    2008-02-15

    This article summarizes the dosimetric results of an International Atomic Energy Agency coordinated research program to investigate the feasibility of adopting guidance levels for invasive coronary artery procedures. The main study collected clinical data from hospitals located in five countries. A total of 2265 coronary angiograms (CA) and 1844 percutaneous coronary interventions (PCI) were analyzed. Substudies evaluated the dosimetric performance of 14 fluoroscopes, skin dose maps obtained using film, the quality of CA procedures, and the complexity of PCI procedures. Kerma-area product (P{sub KA}) guidance levels of 50 and 125 Gy cm{sup 2} are suggested for CA and PCI procedures. These levels should be adjusted for the complexity of the procedures performed in a given institution.

  2. 78 FR 38683 - Availability of Guidance: Establishments Guidance for the Selection of a Commercial or Private...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-27

    ... Food Safety and Inspection Service Availability of Guidance: Establishments Guidance for the Selection of a Commercial or Private Microbiological Testing Laboratory AGENCY: Food Safety and Inspection Service, USDA. ACTION: Notice of availability. SUMMARY: The Food Safety and Inspection Service (FSIS)...

  3. 78 FR 18353 - Guidance for Industry: Blood Establishment Computer System Validation in the User's Facility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... the Federal Register of October 29, 2007 (72 FR 61171), FDA announced the availability of the draft... HUMAN SERVICES Food and Drug Administration Guidance for Industry: Blood Establishment Computer System... ``Guidance for Industry: Blood Establishment Computer System Validation in the User's Facility'' dated...

  4. Self-Awareness. Level One. Career Guidance.

    ERIC Educational Resources Information Center

    Fiendach, Nancy; And Others

    Materials contained in this career guidance unit are designed to develop in five-and six-year-old children an awareness of their senses and the related body organs, likenesses and differences, and self-control. The nineteen activities included in the unit vary in length from twenty to sixty minutes; the entire unit requires approximately ten hours…

  5. Athletics Guidance Aims for Level Field

    ERIC Educational Resources Information Center

    Samuels, Christina A.

    2013-01-01

    A document from the U.S. Department of Education intended to clarify schools' responsibility to make sure students with disabilities have access to extracurricular sports has drawn sharply different opinions. Disability-rights advocates welcome the guidance, while critics say federal officials are pushing requirements that could place new…

  6. 77 FR 25721 - Small Entity Compliance Guide: Bottled Water: Quality Standard: Establishing an Allowable Level...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ... HUMAN SERVICES Food and Drug Administration Small Entity Compliance Guide: Bottled Water: Quality... availability of a guidance for industry entitled ``Bottled Water: Quality Standard: Establishing an Allowable... its bottled water standard of quality regulations by establishing an allowable level for...

  7. 44. Upper level, left to rightground missile guidance system liquid ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    44. Upper level, left to right--ground missile guidance system liquid cooling equipment, guidance and control coupler - Ellsworth Air Force Base, Delta Flight, Launch Facility, On County Road T512, south of Exit 116 off I-90, Interior, Jackson County, SD

  8. 43. Upper level, left to rightground missile guidance system liquid ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    43. Upper level, left to right--ground missile guidance system liquid cooling equipment, guidance and control coupler rack, programmer group - Ellsworth Air Force Base, Delta Flight, Launch Facility, On County Road T512, south of Exit 116 off I-90, Interior, Jackson County, SD

  9. 75 FR 8045 - National Environmental Policy Act (NEPA) Draft Guidance, Establishing, Applying, and Revising...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... QUALITY National Environmental Policy Act (NEPA) Draft Guidance, Establishing, Applying, and Revising Categorical Exclusions Under the National Environmental Policy Act AGENCY: Council on Environmental Quality... Exclusions Under the National Environmental Policy Act.'' SUMMARY: On February 18, 2010, the Council...

  10. Basic Hip Arthroscopy: Anatomic Establishment of Arthroscopic Portals Without Fluoroscopic Guidance.

    PubMed

    Howse, Elizabeth A; Botros, Daniel B; Mannava, Sandeep; Stone, Austin V; Stubbs, Allston J

    2016-04-01

    Hip arthroscopy has gained popularity in recent years for diagnostic and therapeutic hip preservation management. This article details the establishment of arthroscopic portals of the hip, specifically the anterolateral and modified anterior portals without fluoroscopic guidance. The anterolateral portal is established anatomically, and the modified anterior portal is then established under arthroscopic guidance. A through understanding of the hip anatomy allows for these portals to be made both safely and reliably for hip arthroscopies in the modified supine positioned patient. The reduced use of fluoroscopy with this technique lowers the risk of ionizing radiation exposure to the patient and surgeon.

  11. Levels of Engagement in Establishing Coaching Relationships

    ERIC Educational Resources Information Center

    McGatha, Maggie

    2008-01-01

    Case studies of two coaches that examine the levels of engagement of each coach as they worked to establish effective coaching relationships were examined in this study. Data were collected during a seven-month period and included: (a) the coaches' reflective journals; (b) pre- and post-surveys from each coach and teacher; (c) audio-recorded…

  12. Examining the Effect of Teacher Guidance on Collaborative Argumentation in Middle Level Classrooms

    ERIC Educational Resources Information Center

    Hsu, Pi-Sui; Van Dyke, Margot; Chen, Yan

    2015-01-01

    The purpose of this study was to investigate the effect of teacher guidance on the quality of collaborative argumentation in middle level classrooms. Each of six science classes was randomly assigned to either the intervention (teacher guidance) or control condition (minimal teacher guidance). The verbal collaborative argumentation that occurred…

  13. 76 FR 72951 - Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... (74 FR 46433), FDA announced the availability of the draft guidance. Comments on the draft guidance... Differentiation of Human Papillomaviruses; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice... Differentiation of Human Papillomaviruses.'' This guidance document provides industry and Agency staff...

  14. 12 CFR 263.82 - Establishment of minimum capital levels.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Maintain Adequate Capital § 263.82 Establishment of minimum capital levels. The Board has established minimum capital levels for state member banks and bank holding companies in its Capital Adequacy... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Establishment of minimum capital levels....

  15. Group Guidance: Sibling Sessions as a Means of Establishing Rapport in an Inner City Elementary School

    ERIC Educational Resources Information Center

    Dodson, Anna G.

    1971-01-01

    Informal sessions between the school counselor and siblings attending the same school are described. The results indicate greater rapport between students and counselor and a boosting of self referrals, an increase in referrals from parents, and additional information in helping in planning a developmental guidance program. Recommendations are…

  16. 76 FR 570 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ..., plasma, and blood. These devices are used to aid in the diagnosis of Lyme disease. This document does not... detection of antibodies to Borrelia burgdorferi. These devices are used to aid in the diagnosis of Lyme disease. This draft guidance is not final nor is it in effect at this time. DATES: Although you...

  17. 75 FR 73106 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ... Clostridium difficile (C. difficile). This draft guidance is not final nor is it in effect at this time. DATES... Assisting in the Diagnosis of C. difficile Associated Disease'' issued on May 31, 1990. It is updated to... C. difficile nucleic acids (e.g., C. difficile toxin B gene by nucleic acid amplification...

  18. 75 FR 75483 - Guidance for Industry: Recommendations for Blood Establishments: Training of Back-Up Personnel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ... guidance, the H1N1 influenza pandemic has waned in the United States and disruptions in the blood supply..., and Preservation of the Blood Supply in Response to Pandemic (H1N1) 2009 Virus'' dated November 2009... in Response to Pandemic (H1N1) 2009 Virus'' (November 2009). At that time, we anticipated that...

  19. 75 FR 57963 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ... Helicobacter pylori; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food... detecting Helicobacter pylori (H. pylori). This draft guidance is not final nor is it in effect at this time... Detection of Antibodies to Helicobacter pylori,'' to suggest information that submitters provide that...

  20. 77 FR 63355 - Proposed Revision to Emergency Action Level Development Guidance Document

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... revision to the Nuclear Energy Institute (NEI) 99-01, proposed Revision 6, ``Development of Emergency... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Proposed Revision to Emergency Action Level Development Guidance Document AGENCY:...

  1. Shuttle program. MCC Level C formulation requirements: Entry guidance and entry autopilot

    NASA Technical Reports Server (NTRS)

    Harpold, J. C.; Hill, O.

    1980-01-01

    A set of preliminary entry guidance and autopilot software formulations is presented for use in the Mission Control Center (MCC) entry processor. These software formulations meet all level B requirements. Revision 2 incorporates the modifications required to functionally simulate optimal TAEM targeting capability (OTT). Implementation of this logic in the MCC must be coordinated with flight software OTT implementation and MCC TAEM guidance OTT. The entry guidance logic is based on the Orbiter avionics entry guidance software. This MCC requirements document contains a definition of coordinate systems, a list of parameter definitions for the software formulations, a description of the entry guidance detailed formulation requirements, a description of the detailed autopilot formulation requirements, a description of the targeting routine, and a set of formulation flow charts.

  2. MCC level C formulation requirements. Entry guidance and entry autopilot, optional TAEM targeting

    NASA Technical Reports Server (NTRS)

    Harpold, J. C.

    1980-01-01

    The level C software formulations requirements for the entry guidance and the simplified autopilot to be used by the Mission Control Center (MCC) entry processor are presented. The modifications required to functionally simulate optional Terminal Area Energy Management (TAEM) targeting capability (OTT) are incorporated. Implementation of this logic in the MCC must be coordinated with flight software OTT implementation and MCC TAEM guidance OTT. The entry guidance logic is based on the orbiter avionics entry guidance software. Descriptions of the entry guidance detailed formulation requirements, the detailed autopilot formulation requirements, and the targeting routine are given. Also included are a definition of coordinate systems, a list of parameter definitions for the software formulations, and a set of formulation flow charts.

  3. Guidance Manual for Conducting Screening Level Ecological Risk Assessments at the INEL

    SciTech Connect

    R. L. VanHorn; N. L. Hampton; R. C. Morris

    1995-06-01

    This document presents reference material for conducting screening level ecological risk assessments (SLERAs)for the waste area groups (WAGs) at the Idaho National Engineering Laboratory. Included in this document are discussions of the objectives of and processes for conducting SLERAs. The Environmental Protection Agency ecological risk assessment framework is closely followed. Guidance for site characterization, stressor characterization, ecological effects, pathways of contaminant migration, the conceptual site model, assessment endpoints, measurement endpoints, analysis guidance, and risk characterization are included.

  4. Is ICRP guidance on the use of reference levels consistent?

    PubMed

    Hedemann-Jensen, Per; McEwan, Andrew C

    2011-12-01

    In ICRP 103, which has replaced ICRP 60, it is stated that no fundamental changes have been introduced compared with ICRP 60. This is true except that the application of reference levels in emergency and existing exposure situations seems to be applied inconsistently, and also in the related publications ICRP 109 and ICRP 111. ICRP 103 emphasises that focus should be on the residual doses after the implementation of protection strategies in emergency and existing exposure situations. If possible, the result of an optimised protection strategy should bring the residual dose below the reference level. Thus the reference level represents the maximum acceptable residual dose after an optimised protection strategy has been implemented. It is not an 'off-the-shelf item' that can be set free of the prevailing situation. It should be determined as part of the process of optimising the protection strategy. If not, protection would be sub-optimised. However, in ICRP 103 some inconsistent concepts have been introduced, e.g. in paragraph 279 which states: 'All exposures above or below the reference level should be subject to optimisation of protection, and particular attention should be given to exposures above the reference level'. If, in fact, all exposures above and below reference levels are subject to the process of optimisation, reference levels appear superfluous. It could be considered that if optimisation of protection below a fixed reference level is necessary, then the reference level has been set too high at the outset. Up until the last phase of the preparation of ICRP 103 the concept of a dose constraint was recommended to constrain the optimisation of protection in all types of exposure situations. In the final phase, the term 'dose constraint' was changed to 'reference level' for emergency and existing exposure situations. However, it seems as if in ICRP 103 it was not fully recognised that dose constraints and reference levels are conceptually different. The

  5. Establishing Positive Verbal Environments: Strategies for Promoting Social Development through Positive Guidance

    ERIC Educational Resources Information Center

    Meece, Darrell; Rivers, Linda; Wingate, Kimberly

    2009-01-01

    The quality of the verbal environment sets the stage for young children's developing perceptions of themselves and others. This document provides hands-on, practical advice for practitioners to support children's self-perception and coping skills by establishing and maintaining a positive verbal environment. Positive verbal environments enhance…

  6. Community-Based Career Guidance Practices. Vol. I--Elementary Level.

    ERIC Educational Resources Information Center

    Manatee Junior Coll., Bradenton, FL.

    This collection of twelve elementary-level career guidance practices consists of four activities which may be grouped under the heading of novel practices, three activities involving community volunteers, a field trip, a career day activity, and three mobile activities. A standard format (including a description of the practice, its objectives, a…

  7. Community-Based Career Guidance Practices. Vol. II--Secondary Level.

    ERIC Educational Resources Information Center

    Manatee Junior Coll., Bradenton, FL.

    This collection of eighty-six secondary level career guidance practices contains the following nine types of activities: novel practices such as games and role enactments, volunteering, field trips, special career emphases, intern/extern practices, work experience and exploration practices, exchanges, mobile practices, and educator in-services. A…

  8. Community-Based Career Guidance Practices. Vol. III--Postsecondary Level.

    ERIC Educational Resources Information Center

    Manatee Junior Coll., Bradenton, FL.

    This collection of sixty postsecondary-level career guidance practices contains the following nine types of activities: novel practices such as games and role enactment, volunteering, field trips, special career emphases, intern/extern practices, work experience and exploration practices, exchanges, mobile practices, and educator inservices. A…

  9. Final guidance on numeric removal action levels for contaminated drinking water sites. Directive

    SciTech Connect

    1993-10-01

    The purpose of this memorandum is to transmit the final OERR methodology and guidance on the calculation of numeric removal action levels (RALs), to assist Superfund personnel in deciding whether to provide alternate sources of drinking water to populations adversely affected by releases of hazardous substances into the environment.

  10. Trust-level risk evaluation and risk control guidance in the NHS East of England.

    PubMed

    Card, Alan J; Ward, James R; Clarkson, P John

    2014-08-01

    In recent years, the healthcare sector has adopted the use of operational risk assessment tools to help understand the systems issues that lead to patient safety incidents. But although these problem-focused tools have improved the ability of healthcare organizations to identify hazards, they have not translated into measurable improvements in patient safety. One possible reason for this is a lack of support for the solution-focused process of risk control. This article describes a content analysis of the risk management strategies, policies, and procedures at all acute (i.e., hospital), mental health, and ambulance trusts (health service organizations) in the East of England area of the British National Health Service. The primary goal was to determine what organizational-level guidance exists to support risk control practice. A secondary goal was to examine the risk evaluation guidance provided by these trusts. With regard to risk control, we found an almost complete lack of useful guidance to promote good practice. With regard to risk evaluation, the trusts relied exclusively on risk matrices. A number of weaknesses were found in the use of this tool, especially related to the guidance for scoring an event's likelihood. We make a number of recommendations to address these concerns. The guidance assessed provides insufficient support for risk control and risk evaluation. This may present a significant barrier to the success of risk management approaches in improving patient safety.

  11. Dose coefficients and derived guidance and clinical decision levels for contaminated wounds

    SciTech Connect

    Bertelli, Luiz; Toohey, Richard E

    2009-01-01

    The NCRP Wound Model describing the retention of selected radionuclides at the site of a contaminated wound and their uptake into the transfer compartment has been combined with the ICRP element-specific systemic models for those radionuclides to derive dose coefficients for intakes via contaminated wounds. Those coefficients have been used to generate derived guidance levels (i.e., the activity in a wound that would result in an effective dose of 20 or 50 mSv, or in some cases, a committed organ equivalent dose of 500 mSv), and clinical decision levels (i.e., activity levels that would indicate the need for consideration of medical intervention to remove activity from the wound site or administration of decorporation therapy or both), typically set at 5 times the derived guidance levels. Data are provided for the radionuclides commonly encountered at nuclear power plants and nuclear weapons, fuel fabrication or recycling, waste disposal, medical and research facilities. These include: {sup 60}Co, {sup 90}Sr, {sup 99m}Tc, {sup 131}I, {sup 137}Cs, {sup 192}Ir, {sup 210}Po, {sup 226,228}Ra, {sup 228,232}Th, {sup 235,238}U, {sup 237}Np, {sup 238,239}Pu, {sup 241}Am, {sup 242,244}Cm, and {sup 252}Cf.

  12. Shuttle program. MCC level C formulation requirements: Shuttle TAEM guidance and flight control

    NASA Technical Reports Server (NTRS)

    Carman, G. L.

    1980-01-01

    The Level C requirements for the shuttle orbiter terminal area energy management (TAEM) guidance and flight control functions to be incorporated into the Mission Control Center entry profile planning processor are defined. This processor will be used for preentry evaluation of the entry through landing maneuvers, and will include a simplified three degree-of-freedom model of the body rotational dynamics that is necessary to account for the effects of attitude response on the trajectory dynamics. This simulation terminates at TAEM-autoland interface.

  13. Mission planning, mission analysis and software formulation. Level C requirements for the shuttle mission control center orbital guidance software

    NASA Technical Reports Server (NTRS)

    Langston, L. J.

    1976-01-01

    The formulation of Level C requirements for guidance software was reported. Requirements for a PEG supervisor which controls all input/output interfaces with other processors and determines which PEG mode is to be utilized were studied in detail. A description of the two guidance modes for which Level C requirements have been formulated was presented. Functions required for proper execution of the guidance software were defined. The requirements for a navigation function that is used in the prediction logic of PEG mode 4 were discussed. It is concluded that this function is extracted from the current navigation FSSR.

  14. Guidance on the application of quality assurance for characterizing a low-level radioactive waste disposal site

    SciTech Connect

    Pittiglio, C.L. Jr.; Starmer, R.J.; Hedges, D.

    1990-10-01

    This document provides the Nuclear Regulatory Commission's staff guidance to an applicant on meeting the quality control (QC) requirements of Title 10 of the Code of Federal Regulations, Part 61, Section 61.12 (10 CFR 61.12), for a low-level waste disposal facility. The QC requirements combined with the requirements for managerial controls and audits are the basis for developing a quality assurance (QA) program and for the guidance provided herein. QA guidance is specified for site characterization activities necessary to meet the performance objectives of 10 CFR Part 61 and to limit exposure to or the release of radioactivity. 1 tab.

  15. Whole Genome Sequencing of Newly Established Pancreatic Cancer Lines Identifies Novel Somatic Mutation (c.2587G>A) in Axon Guidance Receptor Plexin A1 as Enhancer of Proliferation and Invasion

    PubMed Central

    Abisoye-Ogunniyan, Abisola; Waterfall, Joshua J.; Davis, Sean; Killian, J. Keith; Pineda, Marbin; Ray, Satyajit; McCord, Matt R.; Pflicke, Holger; Burkett, Sandra Sczerba; Meltzer, Paul S.; Rudloff, Udo

    2016-01-01

    The genetic profile of human pancreatic cancers harbors considerable heterogeneity, which suggests a possible explanation for the pronounced inefficacy of single therapies in this disease. This observation has led to a belief that custom therapies based on individual tumor profiles are necessary to more effectively treat pancreatic cancer. It has recently been discovered that axon guidance genes are affected by somatic structural variants in up to 25% of human pancreatic cancers. Thus far, however, some of these mutations have only been correlated to survival probability and no function has been assigned to these observed axon guidance gene mutations in pancreatic cancer. In this study we established three novel pancreatic cancer cell lines and performed whole genome sequencing to discover novel mutations in axon guidance genes that may contribute to the cancer phenotype of these cells. We discovered, among other novel somatic variants in axon guidance pathway genes, a novel mutation in the PLXNA1 receptor (c.2587G>A) in newly established cell line SB.06 that mediates oncogenic cues of increased invasion and proliferation in SB.06 cells and increased invasion in 293T cells upon stimulation with the receptor’s natural ligand semaphorin 3A compared to wild type PLXNA1 cells. Mutant PLXNA1 signaling was associated with increased Rho-GTPase and p42/p44 MAPK signaling activity and cytoskeletal expansion, but not changes in E-cadherin, vimentin, or metalloproteinase 9 expression levels. Pharmacologic inhibition of the Rho-GTPase family member CDC42 selectively abrogated PLXNA1 c.2587G>A-mediated increased invasion. These findings provide in-vitro confirmation that somatic mutations in axon guidance genes can provide oncogenic gain-of-function signals and may contribute to pancreatic cancer progression. PMID:26962861

  16. Whole Genome Sequencing of Newly Established Pancreatic Cancer Lines Identifies Novel Somatic Mutation (c.2587G>A) in Axon Guidance Receptor Plexin A1 as Enhancer of Proliferation and Invasion.

    PubMed

    Sorber, Rebecca; Teper, Yaroslav; Abisoye-Ogunniyan, Abisola; Waterfall, Joshua J; Davis, Sean; Killian, J Keith; Pineda, Marbin; Ray, Satyajit; McCord, Matt R; Pflicke, Holger; Burkett, Sandra Sczerba; Meltzer, Paul S; Rudloff, Udo

    2016-01-01

    The genetic profile of human pancreatic cancers harbors considerable heterogeneity, which suggests a possible explanation for the pronounced inefficacy of single therapies in this disease. This observation has led to a belief that custom therapies based on individual tumor profiles are necessary to more effectively treat pancreatic cancer. It has recently been discovered that axon guidance genes are affected by somatic structural variants in up to 25% of human pancreatic cancers. Thus far, however, some of these mutations have only been correlated to survival probability and no function has been assigned to these observed axon guidance gene mutations in pancreatic cancer. In this study we established three novel pancreatic cancer cell lines and performed whole genome sequencing to discover novel mutations in axon guidance genes that may contribute to the cancer phenotype of these cells. We discovered, among other novel somatic variants in axon guidance pathway genes, a novel mutation in the PLXNA1 receptor (c.2587G>A) in newly established cell line SB.06 that mediates oncogenic cues of increased invasion and proliferation in SB.06 cells and increased invasion in 293T cells upon stimulation with the receptor's natural ligand semaphorin 3A compared to wild type PLXNA1 cells. Mutant PLXNA1 signaling was associated with increased Rho-GTPase and p42/p44 MAPK signaling activity and cytoskeletal expansion, but not changes in E-cadherin, vimentin, or metalloproteinase 9 expression levels. Pharmacologic inhibition of the Rho-GTPase family member CDC42 selectively abrogated PLXNA1 c.2587G>A-mediated increased invasion. These findings provide in-vitro confirmation that somatic mutations in axon guidance genes can provide oncogenic gain-of-function signals and may contribute to pancreatic cancer progression. PMID:26962861

  17. Whole Genome Sequencing of Newly Established Pancreatic Cancer Lines Identifies Novel Somatic Mutation (c.2587G>A) in Axon Guidance Receptor Plexin A1 as Enhancer of Proliferation and Invasion.

    PubMed

    Sorber, Rebecca; Teper, Yaroslav; Abisoye-Ogunniyan, Abisola; Waterfall, Joshua J; Davis, Sean; Killian, J Keith; Pineda, Marbin; Ray, Satyajit; McCord, Matt R; Pflicke, Holger; Burkett, Sandra Sczerba; Meltzer, Paul S; Rudloff, Udo

    2016-01-01

    The genetic profile of human pancreatic cancers harbors considerable heterogeneity, which suggests a possible explanation for the pronounced inefficacy of single therapies in this disease. This observation has led to a belief that custom therapies based on individual tumor profiles are necessary to more effectively treat pancreatic cancer. It has recently been discovered that axon guidance genes are affected by somatic structural variants in up to 25% of human pancreatic cancers. Thus far, however, some of these mutations have only been correlated to survival probability and no function has been assigned to these observed axon guidance gene mutations in pancreatic cancer. In this study we established three novel pancreatic cancer cell lines and performed whole genome sequencing to discover novel mutations in axon guidance genes that may contribute to the cancer phenotype of these cells. We discovered, among other novel somatic variants in axon guidance pathway genes, a novel mutation in the PLXNA1 receptor (c.2587G>A) in newly established cell line SB.06 that mediates oncogenic cues of increased invasion and proliferation in SB.06 cells and increased invasion in 293T cells upon stimulation with the receptor's natural ligand semaphorin 3A compared to wild type PLXNA1 cells. Mutant PLXNA1 signaling was associated with increased Rho-GTPase and p42/p44 MAPK signaling activity and cytoskeletal expansion, but not changes in E-cadherin, vimentin, or metalloproteinase 9 expression levels. Pharmacologic inhibition of the Rho-GTPase family member CDC42 selectively abrogated PLXNA1 c.2587G>A-mediated increased invasion. These findings provide in-vitro confirmation that somatic mutations in axon guidance genes can provide oncogenic gain-of-function signals and may contribute to pancreatic cancer progression.

  18. The impact of NRC guidance on concentration averaging on low level waste sealed source disposal - 11424

    SciTech Connect

    Whitworth, Julia; Stewart, Bill; Cuthbertson, Abigail

    2011-01-20

    As part of its ongoing efforts to revise the Nuclear Regulatory Commission's (NRC) current position on blending to be risk-informed and performance based and its current review of the low-level waste classification codified in 10 CFR 61.55, the Nuclear Regulatory Commission (NRC) has stated that it may review the 1995 'Branch Technical Position on Concentration Averaging and Encapsulation' (BTP), which is still commonly used today. Such a review will have timely advantages, given the lack of commercial disposal availability within the United States for radioactive sealed sources that are in wide beneficial use across the country. The current application of the BTP guidance has resulted in an effective cap on commercial disposal for sources larger than 1.1 TBq (30 Ci). This paper will analyze how the BTP has been implemented with respect to sealed sources, what the implications have been for commercial disposal availability, and whether alternative packaging configurations could be considered for disposal.

  19. Establishment of enzyme immunoassay for measuring serum sultopride levels.

    PubMed

    Someya, T; Shimoda, K; Muratake, T; Nakajima, E; Shirai, A; Funaoka, H; Yashiki, T; Ishii, H; Sunahara, N; Takahashi, S

    2001-06-01

    Measurement of serum sultopride levels was performed using an enzyme immunoassay. Little or no cross-reactivity with metabolites of sultopride and other drugs was found. The results of reproducibility, recovery, and dilution testing were all good enough for clinical use. A comparison between the measurement values of this method (y) with that of high-performance liquid chromatography (x) showed high correlation (n = 211, r = 0.991, p < 0.0001, y = 0.99x + 107.5). In a comparison between the sultopride dose and serum levels in 161 patients, interindividual differences were large (19 times for same doses), implying that the serum level cannot be predicted from the dosage. The method was found to be reliable for serum level measurements of sultopride and useful for monitoring compliance and assessing the optimal dose.

  20. 77 FR 75174 - Draft Guidance for Industry on Providing Submissions in Electronic Format-Summary Level Clinical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ... submitted to and reviewed by CDER as described in the Federal Register of June 26, 2003 (68 FR 38067....'' The draft guidance is intended to assist applicants in the voluntary submission of a clinical dataset... of the individual study site (summary level clinical site dataset). The summary level clinical...

  1. 78 FR 56719 - Draft Guidance for Industry on Arsenic in Apple Juice: Action Level; Supporting Document for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Arsenic in Apple Juice: Action Level; Supporting Document for Action Level for Arsenic in Apple Juice; A Quantitative Assessment of Inorganic Arsenic in Apple Juice; Extension of Comment Period AGENCY: Food and Drug...

  2. 78 FR 42086 - Draft Guidance for Industry on Arsenic in Apple Juice: Action Level; Supporting Document for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Arsenic in Apple Juice: Action Level; Supporting Document for Action Level for Arsenic in Apple Juice; A Quantitative Assessment of Inorganic Arsenic in Apple Juice; Availability AGENCY: Food and Drug Administration, HHS....

  3. Guidance document for prepermit bioassay testing of low-level radioactive waste

    SciTech Connect

    Anderson, S.L.; Harrison, F.L.

    1990-11-01

    In response to the mandate of Public Law 92-532, the Marine Protection, Research, and Sanctuaries Act (MPRSA) of 1972, as amended, the Environmental Protection Agency (EPA) has developed a program to promulgate regulations and criteria to control the ocean disposal of radioactive wastes. The EPA seeks to understand the mechanisms for biological response of marine organisms to the low levels of radioactivity that may arise from the release of these wastes as a result of ocean-disposal practices. Such information will play an important role in determining the adequacy of environmental assessments provided to the EPA in support of any disposal permit application. Although the EPA requires packaging of low-level radioactive waste to prevent release during radiodecay of the materials, some release of radioactive material into the deep-sea environment may occur when a package deteriorates. Therefore, methods for evaluating the impact on biota are being evaluated. Mortality and phenotypic responses are not anticipated at the expected low environmental levels that might occur if radioactive materials were released from the low-level waste packages. Therefore, traditional bioassay systems are unsuitable for assessing sublethal effects on biota in the marine environment. The EPA Office of Radiation Programs (ORP) has had an ongoing program to examine sublethal responses to radiation at the cellular level, using cytogenetic end points. This technical guidance report represents prepermit bioassay procedures that potentially may be applicable to the assessment of effects from a mixture of radionuclides that could be released from a point source at the ocean bottom. Methodologies along with rationale and a discussion of uncertainty are presented for the sediment benthic bioassay protocols identified in this report.

  4. Vintage-level energy and environmental performance of manufacturing establishments

    SciTech Connect

    Boyd, G.A.; Bock, M.J.; Neifer, M.J.; Karlson, S.H.; Ross, M.H.

    1994-05-01

    This report examines the relationship between an industrial plant`s vintage and its energy and environmental performance. Basic questions related to defining vintage and measuring the effects of the manufacturing industry`s vintage distribution of plant-level capacity and energy intensity are explored in general for six energy-intensive sectors (paper, chlorine, nitrogenous fertilizer, aluminum, steel, and cement) at the four-digit standard industrial classification (SIC) level and in detail for two sectors (steel and cement). Results show that greenfield (i.e., newly opened) plants in the paper, steel, and cement industries exhibit low fossil fuel intensities. These results are consistent with expectations. New plants in the paper and steel industries, where processes are undergoing electrification, exhibit high electricity intensities. An analysis of a subsector of the steel industry -- minimills that use scrap-based, electric arc furnaces -- reveals a decline in electricity intensity of 6.2 kilowatt-hours per ton for each newer year of installed vintage. This estimate is consistent with those of engineering studies and raises confidence that analyses of vintage effects in other industries could be conducted. When a vintage measure is assigned on the basis of investment data rather than trade association data, the vintage/performance relationship results for the cement industry are reasonably robust; thus, the analysis of vintage and performance could be extended to sectors for which only US Bureau of the Census data are available.

  5. Prostate ultrasound image segmentation using level set-based region flow with shape guidance

    NASA Astrophysics Data System (ADS)

    Gong, Lixin; Ng, Lydia; Pathak, Sayan D.; Tutar, Ismail; Cho, Paul S.; Haynor, David R.; Kim, Yongmin

    2005-04-01

    Prostate segmentation in ultrasound images is a clinically important and technically challenging task. Despite several research attempts, few effective methods are available. One problem is the limited algorithmic robustness to common artifacts in clinical data sets. To improve the robustness, we have developed a hybrid level set method, which incorporates shape constraints into a region-based curve evolution process. The online segmentation method alternates between two steps, namely, shape model estimation (ME) and curve evolution (CE). The prior shape information is encoded in an implicit parametric model derived offline from manually outlined training data. Utilizing this prior shape information, the ME step tries to compute the maximum a posteriori estimate of the model parameters. The estimated shape is then used to guide the CE step, which in turn provides a new model initialization for the ME step. The process stops automatically when the curve locks onto the specific prostate shape. The ME and the CE steps complement each other to capture both global and local shape details. With shape guidance, this algorithm is less sensitive to initial contour placement and more robust even in the presence of large boundary gaps and strong clutter. Promising results are demonstrated on both synthetic and real prostate ultrasound images.

  6. Uprated fine guidance sensor study

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Future orbital observatories will require star trackers of extremely high precision. These sensors must maintain high pointing accuracy and pointing stability simultaneously with a low light level signal from a guide star. To establish the fine guidance sensing requirements and to evaluate candidate fine guidance sensing concepts, the Space Telescope Optical Telescope Assembly was used as the reference optical system. The requirements review was separated into three areas: Optical Telescope Assembly (OTA), Fine Guidance Sensing and astrometry. The results show that the detectors should be installed directly onto the focal surface presented by the optics. This would maximize throughput and minimize point stability error by not incoporating any additional optical elements.

  7. Diagnostic reference levels for medical exposure of patients: ICRP guidance and related ICRU quantities.

    PubMed

    Rosenstein, Marvin

    2008-11-01

    In Publication 60 of the International Commission on Radiological Protection reference levels were described as values of measured quantities at which some specified action or decision should be taken. One particular form of reference level, the diagnostic reference level, applies specifically to medical exposure of patients. The objective of a diagnostic reference level is to help avoid radiation dose to the patient that does not contribute to the clinical purpose of a medical imaging task. This is accomplished by comparison between the numerical value of the diagnostic reference level and the mean or other appropriate value observed in practice for a suitable reference group of patients or a suitable reference phantom. A diagnostic reference level is not applied to individual patients. Diagnostic reference levels have no direct linkage to the numerical values for dose limits or dose constraints, and it is inappropriate to use them for regulatory or commercial purposes. Diagnostic reference levels should be selected by professional medical bodies (often in conjunction with health and radiation protection authorities) and their values may be specific to a country or region. A diagnostic reference level can be used: (1) to improve a regional, national or local distribution of observed results for a general medical imaging task, by reducing the frequency of unjustified high or low values; (2) to promote attainment of a narrower range of values that represent good practice for a more specific medical imaging task; or (3) to promote attainment of an optimum range of values for a specified medical imaging protocol. Authorized bodies are encouraged to set diagnostic reference levels that best meet their specific needs and that are consistent for the regional, national or local area to which they apply. Report 74 of the International Commission on Radiation Units and Measurements includes a commentary regarding quantities useful in establishing diagnostic reference levels

  8. 76 FR 22903 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing That a Tobacco...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-25

    ... Commercially Marketed in the United States as of February 15, 2007.'' It does not create or confer any rights... Staff; Establishing That a Tobacco Product Was Commercially Marketed in the United States as of February... Product Was Commercially Marketed in the United States as of February 15, 2007.'' This draft...

  9. Structure-based thresholds of toxicological concern-guidance for application to substances present at low levels in the diet

    SciTech Connect

    Renwick, A.G. . E-mail: A.G.Renwick@soton.ac.uk

    2005-09-01

    Health-based guidance values, such as the ADI, use chemical-specific data to determine the highest intake that would be without significant adverse health effects. A threshold of toxicological concern (TTC) is a level of intake predicted to be without adverse effects based on the toxicity of structurally related compounds. The main advantage of the use of TTCs is that the risk of low exposures can be evaluated without the need for chemical-specific animal toxicity data. TTCs have been used for many years for screening the safety of packaging migrants by the FDA in the USA, and of flavoring substances, by the JECFA. A recent reassessment of the use of TTCs, organized by ILSI Europe, has developed a decision tree which allows a systematic approach to the evaluation of low levels of diverse chemicals in food. The decision tree incorporates a series of increasing TTC values into a step-wise approach. Potentially genotoxic carcinogens are considered first, based on the presence of known structural alerts. Aflatoxin-like, azoxy- and nitroso-compounds are removed from consideration because they are the most potent, and a practical TTC could not be established. Other compounds with structural alerts for genotoxicity are allocated a TTC of 0.15 {mu}g/person per day. Compounds without structural alerts for genotoxicity are evaluated based on chemical structure and intake using a series of TTC values derived by the application of a 100-fold uncertainty factor to the 5th percentile of the distribution of NOAELs from chronic studies on compounds sharing similar structural characteristics.

  10. 12 CFR 263.85 - Establishment of increased capital level for specific institutions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... establish a capital level higher than the minimum specified in the Board's Capital Adequacy Guidelines for a... capital levels above those in the Board's Capital Adequacy Guidelines may be necessary and appropriate for... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Establishment of increased capital level...

  11. Automated Guidance from Physiological Sensing to Reduce Thermal-Work Strain Levels on a Novel Task

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This experiment demonstrated that automated pace guidance generated from real-time physiological monitoring allowed least stressful completion of a timed (60 minute limit) 5 mile treadmill exercise. An optimal pacing policy was estimated from a Markov decision process that balanced the goals of the...

  12. FINAL RESEARCH REPORT ON THE EFFECTIVENESS OF TELEVISION IN TEACHING GUIDANCE AT THE SIXTH GRADE LEVEL.

    ERIC Educational Resources Information Center

    LEMKE, OLGA

    EXPERIMENTAL TREATMENTS WERE USED WITH 20 SIXTH-GRADE CLASSES, RANDOMLY ASSIGNED TO ONE OF THE FOLLOWING--(1) A COURSE OF STUDY IN A SERIES OF 21 LESSONS, 20 MINUTES IN LENGTH, ON GUIDANCE WHICH WAS PRESENTED THROUGH THE MEDIUM OF TELEVISION TO THE "TV GROUP," AND (2) THE SAME COURSE OF STUDY, PRESENTED TO THE "TEACHER-LED GROUP" IN THE CLASSROOM…

  13. Comparison of Two Levels of Guidance in Teaching Elementary School Mathematics

    ERIC Educational Resources Information Center

    Bassler, Otto C.; And Others

    1971-01-01

    Briefly reviews important research dealing with the effectiveness of non-directed (discovery) learning as compared to guided learning. Describes experiment designed to assess the relative effects of intermediate and maximal guidance in learning selected mathematic concepts using programed materials. Results reveal no reliable difference between…

  14. School-Community Guidance Center, 1990-91: Reaching for New Levels.

    ERIC Educational Resources Information Center

    Williams-Robertson, Lydia

    This document describes the School-Community Guidance Center (SCGC), a center created by the Austin (Texas) Independent School District to provide support services for students assigned to the Alternative Learning Center (ALC) and the Gardner-Betts House (GBH) because of their contact with the juvenile justice system or their at-risk status. The…

  15. MCC level C formulation requirements. Shuttle TAEM guidance and flight control, STS-1 baseline

    NASA Technical Reports Server (NTRS)

    Carman, G. L.; Montez, M. N.

    1980-01-01

    The TAEM guidance and body rotational dynamics models required for the MCC simulation of the TAEM mission phase are defined. This simulation begins at the end of the entry phase and terminates at TAEM autoland interface. The logic presented is the required configuration for the first shuttle orbital flight (STS-1). The TAEM guidance is simulated in detail. The rotational dynamics simulation is a simplified model that assumes that the commanded rotational rates can be achieved in the integration interval. Thus, the rotational dynamics simulation is essentially a simulation of the autopilot commanded rates and integration of these rates to determine orbiter attitude. The rotational dynamics simulation also includes a simulation of the speedbrake deflection. The body flap and elevon deflections are computed in the orbiter aerodynamic simulation.

  16. 21 CFR 509.4 - Establishment of tolerances, regulatory limits, and action levels.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... IN ANIMAL FOOD AND FOOD-PACKAGING MATERIAL General Provisions § 509.4 Establishment of tolerances... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Establishment of tolerances, regulatory limits, and action levels. 509.4 Section 509.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT...

  17. Annotated list of regulations and guidance applicable to temporary storage of commercial Low-Level Radioactive Waste

    SciTech Connect

    Not Available

    1992-04-01

    Compliance with the Low-Level Radioactive Waste Policy Amendments Act of 1985 (the Act) (Public Law 99-240), requires that States be responsible for the management and disposal of low-level radioactive waste (LLW) generated within their borders on January 1, 1993. Many States have indicated that they will not have LLW disposal capacity by the deadline and will need to consider other waste management options. A major option will be temporary storage of LLW. This document was prepared to help current and potential LLW storage management systems comply with applicable regulations. A list of major agencies and Federal laws applicable to storage of LLW and an annotated listing of regulations, guidance, and reference material applicable to temporary storage of LLW are provided. Also, the regulations and guidance are categorized into seven major areas of applicability concerning temporary storage of LLW. When considering temporary storage, States and compact regions have two broad options: (1) storage by the generators and brokers at the point of generation or collection, and (2) storage at a centralized temporary storage facility. Centralized temporary storage could take place at more than one facility, and States could choose to combine the options with some centralized storage and some storage at the generators.

  18. 7 CFR 1450.213 - Levels and rates for establishment payments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Levels and rates for establishment payments. 1450.213 Section 1450.213 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE...

  19. 7 CFR 1450.213 - Levels and rates for establishment payments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Levels and rates for establishment payments. 1450.213 Section 1450.213 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE...

  20. 7 CFR 1450.213 - Levels and rates for establishment payments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Levels and rates for establishment payments. 1450.213 Section 1450.213 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE...

  1. 7 CFR 1450.213 - Levels and rates for establishment payments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Levels and rates for establishment payments. 1450.213 Section 1450.213 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS BIOMASS CROP ASSISTANCE...

  2. EVALUATION OF LITERATURE ESTABLISHING SCREENING LEVELS FOR TERRESTRIAL PLANTS/INVERTEBRATES

    EPA Science Inventory

    Scientific publications often lack key information on experimental design or do not follow appropriate test methods and therefore cannot be used in deriving reliable benchmarks. Risk based soil screening levels (Eco-SSLs) are being established for chemicals of concern to terrestr...

  3. 21 CFR 109.4 - Establishment of tolerances, regulatory limits, and action levels.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Establishment of tolerances, regulatory limits, and action levels. 109.4 Section 109.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION UNAVOIDABLE CONTAMINANTS IN FOOD FOR HUMAN CONSUMPTION AND FOOD-PACKAGING...

  4. Use of sediment serial dilution series to establish biological effect levels and clean-up goals

    SciTech Connect

    Timmer, E.; DeLong, T.; Millard, J.; Dobroski, C.

    1995-12-31

    A sediment serial dilution study was used to determine biological effect levels for two freshwater invertebrates, Chironomus tentans and Hyalella azteca. The sediments for the test were collected from a New England brook which contained elevated levels of lead and polychlorinated aromatic hydrocarbons. The objective of the sediment dilution study was two-fold: (1 ) to provide a site-specific estimation of biological effect levels, thus reducing uncertainties associated with using literature-based values, and (2) to establish clean-up goals specific to this freshwater system.

  5. Emplacement Guidance for Criticality Safety in Low-Level-Waste Disposal

    SciTech Connect

    Elam, K.R.

    2001-06-23

    The disposal of low-level radioactive waste (LLW) containing special nuclear material (SNM) presents some unusual challenges for LLW disposal site operators and regulators. Radiological concerns associated with the radioactive decay of the SNM are combined with concerns associated with the avoidance of a nuclear criticality both during handling and after disposal of the waste. Currently, there are three operating LLW disposal facilities: Envirocare, Barnwell, and Richland. All these facilities are located in U.S. Nuclear Regulatory Commission (NRC) Agreement States and are regulated by their respective state: Utah, South Carolina, and Washington. As such, the amount of SNM that can be possessed by each of these facilities is limited to the 10 CFR Part 150 limits (i.e., 350 g of uranium-235, 200 g of uranium-233, and 200 g of Pu, with the sum-of-fractions rule applying), unless an exemption is issued. NRC has applied these SNM possession limits to above-ground possession. The purpose of this report is to provide data which could demonstrate that SNM waste at emplacement will not cause a nuclear criticality accident. Five different SNM isotopic compositions were studied: 100 wt% enriched uranium, 10 wt% enriched uranium, uranium-233, plutonium-239, and an isotopic mixture of plutonium (76 wt% plutonium-239, 12 wt% plutonium-240, and 12 wt% plutonium-241). Three different graded-approach methods are presented. The first graded-approach method is the most conservative and may be applicable to facilities that dispose of very low areal densities of SNM, or dispose of material with a low average enrichment. It relies on the calculation of average areal density or on the average enrichment of SNM. The area over which averaging may be performed is also specified, but the emplacement depth is not constrained. The second graded-approach method relies on limiting the average concentration by weight of SNM in the waste, and on limiting the depth of the emplacement. This method

  6. Primary School Teachers' Inspection in Turkey: Primary School Teachers' Expectations about Inspectors' Guidance Roles and the Realisation Level of These Expectations

    ERIC Educational Resources Information Center

    Polat, Soner; Ugurlu, Celal Teyyar

    2008-01-01

    The aim of this research is to point out primary school teachers' expectations about inspectors' guidance roles and the realisation level of these expectations. The data used in this research that will be done in descriptive scanning model is collected from the views of primary school teachers selected randomly from Balikesir, Batman and Hatay.…

  7. DOE Waste Treatability Group Guidance

    SciTech Connect

    Kirkpatrick, T.D.

    1995-01-01

    This guidance presents a method and definitions for aggregating U.S. Department of Energy (DOE) waste into streams and treatability groups based on characteristic parameters that influence waste management technology needs. Adaptable to all DOE waste types (i.e., radioactive waste, hazardous waste, mixed waste, sanitary waste), the guidance establishes categories and definitions that reflect variations within the radiological, matrix (e.g., bulk physical/chemical form), and regulated contaminant characteristics of DOE waste. Beginning at the waste container level, the guidance presents a logical approach to implementing the characteristic parameter categories as part of the basis for defining waste streams and as the sole basis for assigning streams to treatability groups. Implementation of this guidance at each DOE site will facilitate the development of technically defined, site-specific waste stream data sets to support waste management planning and reporting activities. Consistent implementation at all of the sites will enable aggregation of the site-specific waste stream data sets into comparable national data sets to support these activities at a DOE complex-wide level.

  8. Corporate information management guidance

    SciTech Connect

    1997-08-01

    At the request of the Department of Energy`s (DOE) Information Management (IM) Council, IM representatives from nearly all Headquarters (HQ) organizations have been meeting over the past year as the Corporate Guidance Group (CGG) to develop useful and sound corporate information management (IM) guidance. The ability of the Department`s IM community to develop such unified guidance continues to be critical to the success of future Departmental IM planning processes and the establishment of a well-coordinated IM environment between Headquarters and field organizations. This report, with 26 specific corporate IM guidance items documented and unanimously agreed to, as well as 12 items recommended for further development and 3 items deferred for future consideration, represents a highly successful effort by the IM community. The effort has proven that the diverse DOE organizations can put aside individual preferences and work together towards a common and mutually beneficial goal. In examining most areas and issues associated with information management in the Department, they have developed specific, far-reaching, and useful guidance. The IM representatives recommend that the documented guidance items provided in this report and approved by the DOE IM Council be followed by all IM organizations. The representatives also strongly recommend that the guidance process developed by the CGG be the single process for developing corporate IM guidance.

  9. Industrial Sites Project Establishment of Final Action Levels, Rev. No.: 0

    SciTech Connect

    Boehlecke, Robert F.

    2006-02-01

    The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) oversees numerous sites on the Nevada Test Site (NTS) and other locations in the State of Nevada that have been impacted by activities related to the development and testing of nuclear devices and by other activities. NNSA/NSO is responsible for protecting members of the public, including site workers, from harmful exposure to both chemical and radiological contaminants at these sites as they remediate these sites. The Nevada Division of Environmental Protection (NDEP) is the primary state agency responsible for protection of human health and the environment with respect to chemical and radiological wastes. In 1996 the DOE, U.S. Department of Defense, and the State of Nevada entered into an agreement known as the ''Federal Facility Agreement and Consent Order'' (FFACO) (1996). Appendix VI to the FFACO describes the strategy employed to plan, implement, and complete environmental corrective action activities at NTS and other locations in the state of Nevada. One of the categories of corrective action units (CAUs) is Industrial Sites, which consists of approximately 1,150 locations that may require some level of investigation and corrective action. To evaluate the need for the extent of corrective action at a particular site, NNSA/NSO assesses the potential impacts to receptors by comparing measurements of contaminant concentrations to risk-based (chemical) and dose-based (radionuclide) standards (action levels). Preliminary action levels (PALs) are established as part of the data quality objective (DQO) process, and are presented in one or more FFACO documents generated as part of the corrective action process. This document formally defines and clarifies the NDEP-approved process NNSA/NSO Industrial Sites Project uses to fulfill the requirements of the FFACO and state regulations. This process establishes final action levels (FALs) based on the risk

  10. Establishment of multi-slice computed tomography (MSCT) reference level in Johor, Malaysia

    NASA Astrophysics Data System (ADS)

    Karim, M. K. A.; Hashim, S.; Bakar, K. A.; Muhammad, H.; Sabarudin, A.; Ang, W. C.; Bahruddin, N. A.

    2016-03-01

    Radiation doses from computed tomography (CT) are the highest and most hazardous compared to other imaging modalities. This study aimed to evaluate radiation dose in Johor, Malaysia to patients during computed tomography examinations of the brain, chest and abdomen and to establish the local diagnostic reference levels (DRLs) as are present with the current, state- of-art, multi-slice CT scanners. Survey forms were sent to five centres performing CT to obtain data regarding acquisition parameters as well as the dose information from CT consoles. CT- EXPO (Version 2.3.1, Germany) was used to validate the dose information. The proposed DRLs were indicated by rounding the third quartiles of whole dose distributions where mean values of CTDIw (mGy), CTDIvol (mGy) and DLP (mGy.cm) were comparable with other reference levels; 63, 63, and 1015 respectively for CT Brain; 15, 14, and 450 respectively for CT thorax and 16, 17, and 590 respectively for CT abdomen. The study revealed that the CT practice and dose output were revolutionised, and must keep up with the pace of introductory technology. We suggest that CTDIvol should be included in current national DRLs, as modern CTs are configured with a higher number of detectors and are independent of pitch factors.

  11. Establishing remediation levels in response to a radiological dispersal event (or dirty bomb).

    SciTech Connect

    Elcock, D.; Klemic, G. A.; Taboas, A. L.; Environmental Assessment; Environmental Measurements Lab.; DOE-CH

    2004-05-01

    The detonation of a radiological dispersal device (RDD) could produce significant social and economic damage, the extent of which would depend largely on how quickly and effectively cleanup levels were established and on public acceptance of those levels. This paper shows that current radiological cleanup laws and regulations, models for converting dose or risk goals to cleanup concentrations, and existing site-specific criteria were not designed specifically for RDD cleanups but, absent changes, would apply by default. The goals and approaches of these legal and methodological structures often conflict; using them in response to terrorism could undermine public confidence, cause delays, and produce unnecessary costs or unacceptable cleanups. RDD cleanups would involve immediate priorities not envisioned in the existing radiological cleanup framework, such as balancing radiation risks with the health, economic, and other societal impacts associated with access to the infrastructure necessary to sustain society (e.g., hospitals, bridges, utilities). To minimize the achievement of terrorism goals, the elements of an RDD cleanup response -- including updating existing legal/regulatory structures to clarify federal authority, goals, and methods for developing RDD cleanup criteria -- must be in place soon; given the complexity of the issues and the potential societal impact, this effort should be expedited.

  12. Establishing the level of cylindrical rotation in boxy/peanut bulges

    NASA Astrophysics Data System (ADS)

    Molaeinezhad, A.; Falcón-Barroso, J.; Martínez-Valpuesta, I.; Khosroshahi, H. G.; Balcells, M.; Peletier, R. F.

    2016-02-01

    We present SAURON integral-field observations of a sample of 12 mid-to-high-inclination disc galaxies, to unveil hidden bars on the basis of their kinematics, i.e. the correlation between velocity and h3 profiles, and to establish their degree of cylindrical rotation. For the latter, we introduce a method to quantify cylindrical rotation that is robust against inner disc components. We confirm high levels of cylindrical rotation in boxy/peanut bulges, but also observe this feature in a few galaxies with rounder bulges. We suggest that these are also barred galaxies with end-on orientations. Re-analysing published data for our own Galaxy using this new method, we determine that the Milky Way bulge is cylindrically rotating at the same level as the strongest barred galaxy in our sample. Finally, we use self-consistent three-dimensional N-body simulations of bar-unstable discs to study the dependence of cylindrical rotation on the bar's orientation and host galaxy inclination.

  13. Establishing tolerable dungeness crab (Cancer magister) and razor clam (Siliqua patula) domoic acid contaminant levels.

    PubMed Central

    Mariën, K

    1996-01-01

    Domoic acid has been found in razor clams (Siliqua patula) and dungeness crabs (Cancer magister) in Washington State and elsewhere on the West Coast of the United States. Due to toxic effects associated with domoic acid exposure, an effort has been made to establish tolerable domoic acid levels in crabs and clams obtained from commercial harvest and sale and from individual recreational harvesting. To accomplish this, the amount of clams and crabs consumed by populations of concern was determined, a tolerable daily intake (TDI) was developed for individuals most sensitive to effects of this compound, and the TDI was equated with consumption patterns to determine tolerable clam and crab domoic acid levels. Results indicate that the primary health effects associated with domoic acid toxicity can be averted in populations of concern and for others consuming crabs or clams less frequently (or in lesser quantity) if domoic acid contaminant concentration does not exceed 30 mg/kg in the hepatopancreas and viscera of dungeness crabs or 20 mg/kg in clams. PMID:8959413

  14. SU-E-I-33: Establishment of CT Diagnostic Reference Levels in Province Nova Scotia

    SciTech Connect

    Tonkopi, E; Abdolell, M; Duffy, S

    2015-06-15

    Purpose: To evaluate patient radiation dose from the most frequently performed CT examinations and to establish provincial diagnostic reference levels (DRLs) as a tool for protocol optimization. Methods: The study investigated the following CT examinations: head, chest, abdomen/pelvis, and chest/abdomen/pelvis (CAP). Dose data, volume CT dose index (CTDIvol) and dose-length product (DLP), were collected from 15 CT scanners installed during 2004–2014 in 11 hospital sites of Nova Scotia. All scanners had dose modulation options and multislice capability (16–128 detector rows). The sample for each protocol included 15 average size patients (70±20 kg). Provincial DRLs were calculated as the 75th percentile of patient dose distributions. The differences in dose between hospitals were evaluated with a single factor ANOVA statistical test. Generalized linear modeling was used to determine the factors associated with higher radiation dose. A sample of 36 abdominal studies performed on three different scanners was blinded and randomized for an assessment by an experienced radiologist who graded the imaging quality of anatomic structures. Results: Data for 900 patients were collected. The DRLs were proposed using CTDIvol (mGy) and DLP (mGy*cm) values for CT head (67 and 1049, respectively), chest (12 and 393), abdomen/pelvis (16 and 717), and CAP (14 and 1034). These DRLs were lower than the published national data except for the head CTDIvol. The differences between the means of the dose distributions from each scanner were statistically significant (p<0.05) for all examinations. A very weak correlation was found between the dose and the scanner age or the number of slices with Pearson’s correlation coefficients of 0.011–0.315. The blinded analysis of image quality demonstrated no clinically significant difference except for the noise category. Conclusion: Provincial DRLs were established for typical CT examinations. The variations in dose between the hospitals

  15. A modular, plasmin-sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere system for establishing growth factor gradients in nerve guidance conduits.

    PubMed

    Roam, Jacob L; Yan, Ying; Nguyen, Peter K; Kinstlinger, Ian S; Leuchter, Michael K; Hunter, Daniel A; Wood, Matthew D; Elbert, Donald L

    2015-12-01

    Peripheral nerve regeneration is a complex problem that, despite many advancements and innovations, still has sub-optimal outcomes. Compared to biologically derived acellular nerve grafts and autografts, completely synthetic nerve guidance conduits (NGC), which allow for precise engineering of their properties, are promising but still far from optimal. We have developed an almost entirely synthetic NGC that allows control of soluble growth factor delivery kinetics, cell-initiated degradability and cell attachment. We have focused on the spatial patterning of glial-cell derived human neurotrophic factor (GDNF), which promotes motor axon extension. The base scaffolds consisted of heparin-containing poly(ethylene glycol) (PEG) microspheres. The modular microsphere format greatly simplifies the formation of concentration gradients of reversibly bound GDNF. To facilitate axon extension, we engineered the microspheres with tunable plasmin degradability. 'Click' cross-linking chemistries were also added to allow scaffold formation without risk of covalently coupling the growth factor to the scaffold. Cell adhesion was promoted by covalently bound laminin. GDNF that was released from these microspheres was confirmed to retain its activity. Graded scaffolds were formed inside silicone conduits using 3D-printed holders. The fully formed NGC's contained plasmin-degradable PEG/heparin scaffolds that developed linear gradients in reversibly bound GDNF. The NGC's were implanted into rats with severed sciatic nerves to confirm in vivo degradability and lack of a major foreign body response. The NGC's also promoted robust axonal regeneration into the conduit.

  16. A modular, plasmin-sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere system for establishing growth factor gradients in nerve guidance conduits.

    PubMed

    Roam, Jacob L; Yan, Ying; Nguyen, Peter K; Kinstlinger, Ian S; Leuchter, Michael K; Hunter, Daniel A; Wood, Matthew D; Elbert, Donald L

    2015-12-01

    Peripheral nerve regeneration is a complex problem that, despite many advancements and innovations, still has sub-optimal outcomes. Compared to biologically derived acellular nerve grafts and autografts, completely synthetic nerve guidance conduits (NGC), which allow for precise engineering of their properties, are promising but still far from optimal. We have developed an almost entirely synthetic NGC that allows control of soluble growth factor delivery kinetics, cell-initiated degradability and cell attachment. We have focused on the spatial patterning of glial-cell derived human neurotrophic factor (GDNF), which promotes motor axon extension. The base scaffolds consisted of heparin-containing poly(ethylene glycol) (PEG) microspheres. The modular microsphere format greatly simplifies the formation of concentration gradients of reversibly bound GDNF. To facilitate axon extension, we engineered the microspheres with tunable plasmin degradability. 'Click' cross-linking chemistries were also added to allow scaffold formation without risk of covalently coupling the growth factor to the scaffold. Cell adhesion was promoted by covalently bound laminin. GDNF that was released from these microspheres was confirmed to retain its activity. Graded scaffolds were formed inside silicone conduits using 3D-printed holders. The fully formed NGC's contained plasmin-degradable PEG/heparin scaffolds that developed linear gradients in reversibly bound GDNF. The NGC's were implanted into rats with severed sciatic nerves to confirm in vivo degradability and lack of a major foreign body response. The NGC's also promoted robust axonal regeneration into the conduit. PMID:26352518

  17. Using Readability Formulas to Establish the Grade Level Difficulty of Software.

    ERIC Educational Resources Information Center

    Clariana, Roy B.

    1993-01-01

    Compared the grade level difficulty obtained from seven readability formulas to student reading levels from two national standardized tests to determine which formulas best determined the readability of computer-based text. Found that the Flesch-Kincaid, FOG, and ARI formulas provided the best estimate of reading grade level of computer-based text…

  18. RESEARCH TO ESTABLISH A COLLEGE-LEVEL CURRICULUM IN GLASS. TECHNICAL PROGRESS REPORT, NUMBER 2.

    ERIC Educational Resources Information Center

    WILLSON, RICHARD

    THE PURPOSE OF THE RESEARCH IS TO CORRELATE A COLLECTED MASS OF INFORMATION RELATED TO THE ACCEPTED NEED TO ESTABLISH A CURRICULUM FOR TEACHING GLASS AS A FINE ART MATERIAL IN THE UNITED STATES. AN ARTIST OR AN ARCHITECT WHO WISHES TO LEARN THE POTENTIAL USE OF GLASS MUST GO TO EUROPE, AS NO COMPREHENSIVE TEACHING OF GLASS AS A FINE ART EXISTS ON…

  19. 75 FR 45584 - Planning and Establishment of State-Level Exchanges; Request for Comments Regarding Exchange...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ... website containing standardized comparative information on QHPs; assigning ratings to each QHP offered... certification criteria include, at a minimum: Meeting marketing requirements; ensuring a sufficient choice of... providers? b. What issues need to be considered in establishing appropriate minimum standards for...

  20. The Development of a Methodology for Establishing Task-Level Performance Standards for Apprentice, Journeyman, and Master Skill Levels in the U.S. Navy

    ERIC Educational Resources Information Center

    Hedge, Jerry W.; Borman, Walter C.; Kubisiak, U. Christean; Bourne, Mark J.

    2007-01-01

    The goal of the project examined here was to establish performance standards for Navy aerographer's mate (AG) enlisted sailors at three skill levels. We used an online expert judgment task and consensus workshop methodology to gather information from subject matter experts on minimal proficiency requirements for each task within each skill level.…

  1. 76 FR 64810 - Beverages: Bottled Water Quality Standard; Establishing an Allowable Level for di(2-ethylhexyl...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... FR 41612), FDA published a proposal (``the 1993 proposed rule'') to revise the bottled water quality... adopting the allowable level for DEHP in the bottled water quality standard as proposed (58 FR 41612... be found in bottled water in levels above the standard. C. Benefits In the Economic Impact...

  2. Comparing alternative approaches to establishing regulatory levels for reproductive toxicants: DBCP as a case study.

    PubMed Central

    Pease, W; Vandenberg, J; Hooper, K

    1991-01-01

    This paper compares four alternative approaches for deriving regulatory levels for reproductive toxicants by applying them to the available data on the human spermatotoxicant 1,2-dibromo-3-chloropropane (DBCP). The alternatives examined include the Proposition 65 approach (application of a mandatory 1000-fold uncertainty factor to a no-observed-adverse-effect level [NOAEL]), the Environmental Protection Agency (EPA) approach (application of flexible uncertainty factors to a NOAEL), the Benchmark Dose approach (application of flexible uncertainty factors to a dose associated with a known level of change in a reproductive parameter), and the Quantitative Risk Estimation approach (using low-dose linear extrapolation and a model of the relationship between sperm count and infertility). Applied to DBCP, these approaches do not produce substantially different estimates of allowable exposure levels. However, the approaches do have different data requirements and provide different amounts of information on reproductive hazards to risk managers and the public. Neither the Proposition 65 nor the EPA approach provides information about the extent of health risk remaining at a regulatory level. In contrast, the Benchmark Dose approach can provide estimates of the magnitude of sperm count reduction at a regulatory level, and the Quantitative Risk Estimation approach can provide estimates of exposure-induced infertility. PMID:2040244

  3. Patient grouping for dose surveys and establishment of diagnostic reference levels in paediatric computed tomography.

    PubMed

    Vassileva, J; Rehani, M

    2015-07-01

    There has been confusion in literature on whether paediatric patients should be grouped according to age, weight or other parameters when dealing with dose surveys. The present work aims to suggest a pragmatic approach to achieve reasonable accuracy for performing patient dose surveys in countries with limited resources. The analysis is based on a subset of data collected within the IAEA survey of paediatric computed tomography (CT) doses, involving 82 CT facilities from 32 countries in Asia, Europe, Africa and Latin America. Data for 6115 patients were collected, in 34.5 % of which data for weight were available. The present study suggests that using four age groups, <1, >1-5, >5-10 and >10-15 y, is realistic and pragmatic for dose surveys in less resourced countries and for the establishment of DRLs. To ensure relevant accuracy of results, data for >30 patients in a particular age group should be collected if patient weight is not known. If a smaller sample is used, patient weight should be recorded and the median weight in the sample should be within 5-10 % from the median weight of the sample for which the DRLs were established. Comparison of results from different surveys should always be performed with caution, taking into consideration the way of grouping of paediatric patients. Dose results can be corrected for differences in patient weight/age group.

  4. Patient grouping for dose surveys and establishment of diagnostic reference levels in paediatric computed tomography.

    PubMed

    Vassileva, J; Rehani, M

    2015-07-01

    There has been confusion in literature on whether paediatric patients should be grouped according to age, weight or other parameters when dealing with dose surveys. The present work aims to suggest a pragmatic approach to achieve reasonable accuracy for performing patient dose surveys in countries with limited resources. The analysis is based on a subset of data collected within the IAEA survey of paediatric computed tomography (CT) doses, involving 82 CT facilities from 32 countries in Asia, Europe, Africa and Latin America. Data for 6115 patients were collected, in 34.5 % of which data for weight were available. The present study suggests that using four age groups, <1, >1-5, >5-10 and >10-15 y, is realistic and pragmatic for dose surveys in less resourced countries and for the establishment of DRLs. To ensure relevant accuracy of results, data for >30 patients in a particular age group should be collected if patient weight is not known. If a smaller sample is used, patient weight should be recorded and the median weight in the sample should be within 5-10 % from the median weight of the sample for which the DRLs were established. Comparison of results from different surveys should always be performed with caution, taking into consideration the way of grouping of paediatric patients. Dose results can be corrected for differences in patient weight/age group. PMID:25836695

  5. Tank 241-C-106 thermal hydraulic analysis to establish the cooling liquid at a minimum level

    SciTech Connect

    Bander, T.J.; Thurgood, M.J.

    1995-12-31

    This report presents the computer simulations used to evaluate whether tank 241-C-106 can be operated at new lower operating liquid levels without significant reduction in th heat removal capability of the tank ventilation system. It is concluded that if the tank is operated with the liquid level between 72 and 74 in. the evaporation of the tank will be similar to what it is for the current operating level of 75 to 79 in. Analyses predict that for both operating limits voids will form during the summer months and disappear during the winter months. The waste temperatures for both operating limits will be close to the same. Installation of a chiller can maintain the highest waste temperatures below the saturation temperature (i.e., no voids will form) year round provided 67% of the original pool surface area is maintained for evaporation

  6. Establishing optimal project-level strategies for pavement maintenance and rehabilitation - A framework and case study

    NASA Astrophysics Data System (ADS)

    Irfan, Muhammad; Bilal Khurshid, Muhammad; Bai, Qiang; Labi, Samuel; Morin, Thomas L.

    2012-05-01

    This article presents a framework and an illustrative example for identifying the optimal pavement maintenance and rehabilitation (M&R) strategy using a mixed-integer nonlinear programming model. The objective function is to maximize the cost-effectiveness expressed as the ratio of the effectiveness to the cost. The constraints for the optimization problem are related to performance, budget, and choice. Two different formulations of effectiveness are derived using treatment-specific performance models for each constituent treatment of the strategy; and cost is expressed in terms of the agency and user costs over the life cycle. The proposed methodology is demonstrated using a case study. Probability distributions are established for the optimization input variables and Monte Carlo simulations are carried out to yield optimal solutions. Using the results of these simulations, M&R strategy contours are developed as a novel tool that can help pavement managers quickly identify the optimal M&R strategy for a given pavement section.

  7. Establishing Junior-Level Colleges in Developing Nations: A Site Selection Process Using Data from Uganda

    ERIC Educational Resources Information Center

    Iaeger, Paula Irene

    2012-01-01

    This research synthesizes data and presents it using mapping software to help to identify potential site locations for community-centered higher education alternatives and more traditional junior-level colleges in Uganda. What factors can be used to quantify one site over another for the location of such an institution and if these factors can be…

  8. SU-E-P-10: Establishment of Local Diagnostic Reference Levels of Routine Exam in Computed Tomography

    SciTech Connect

    Yeh, M; Wang, Y; Weng, H

    2015-06-15

    Introduction National diagnostic reference levels (NDRLs) can be used as a reference dose of radiological examination can provide radiation dose as the basis of patient dose optimization. Local diagnostic reference levels (LDRLs) by periodically view and check doses, more efficiency to improve the way of examination. Therefore, the important first step is establishing a diagnostic reference level. Computed Tomography in Taiwan had been built up the radiation dose limit value,in addition, many studies report shows that CT scan contributed most of the radiation dose in different medical. Therefore, this study was mainly to let everyone understand DRL’s international status. For computed tomography in our hospital to establish diagnostic reference levels. Methods and Materials: There are two clinical CT scanners (a Toshiba Aquilion and a Siemens Sensation) were performed in this study. For CT examinations the basic recommended dosimetric quantity is the Computed Tomography Dose Index (CTDI). Each exam each different body part, we collect 10 patients at least. Carried out the routine examinations, and all exposure parameters have been collected and the corresponding CTDIv and DLP values have been determined. Results: The majority of patients (75%) were between 60–70 Kg of body weight. There are 25 examinations in this study. Table 1 shows the LDRL of each CT routine examination. Conclusions: Therefore, this study would like to let everyone know DRL’s international status, but also establishment of computed tomography of the local reference levels for our hospital, and providing radiation reference, as a basis for optimizing patient dose.

  9. Student Levels of Cognitive Development: Establishing Links between Logical Thinking Skills and Success in Earth Science

    NASA Astrophysics Data System (ADS)

    Steer, D. N.; McConnell, D. A.; Owens, K.

    2003-12-01

    Students in inquiry-based, general education Earth Science courses were found to display a wide range of logical thinking skills that are known indicators of success in science courses. The Group Assessment of Logical Thinking instrument that tests six logical operations was administered on the first day of class and near the end of the course. Such tests can be used to assess a student's overall level of cognitive development (concrete, transitional or formal) and specific logical thinking strengths or weaknesses. Results from paired pre- and post-course logical thinking tests of 393 students indicated that 25% of the incoming students were concrete, 30% were transitional and 45% were formal thinkers. Concrete and transitional thinkers were far more likely to withdraw from or fail the course when compared to their formal thinking peers (35%, 25% and 10% respectively). Differences in scores between genders were significant with 210 females testing at 30% concrete, 35% transitional and 35% formal on the pretest compared to 183 males who tested 15% concrete, 25% transitional and 60% formal. Overall logical thinking scores of students increased significantly in every inquiry-based class with lecture-based classes showing overall lower increases. Post-test data indicated that there were fewer concrete thinkers (16% female, 7% male), little change in the number of transitional thinkers (30% female, 23% male) and more formal thinkers (54% female, 70% male) toward the end of the inquiry-based course. Scores on two of the logical operations, conservation and probability, were sufficient to separate those who received a high grade (A or B in course) from those were unsuccessful (D, F or withdrew). Students who score low in conservation operations (n=46) tend to rely on intuition rather than logic when trying to understand typical Earth System concepts such as plate tectonics, atmospheric processes and climate change. Students who score low in probability skills (n=46) have

  10. Regulatory neutrality is essential to establishing a level playing field for accountable care organizations.

    PubMed

    Bacher, Gary E; Chernew, Michael E; Kessler, Daniel P; Weiner, Stephen M

    2013-08-01

    Accountable care organizations (ACOs) are among the most widely discussed models for encouraging movement away from fee-for-service payment arrangements. Although ACOs have the potential to slow health spending growth and improve quality of care, regulating them poses special challenges. Regulations, particularly those that affect both ACOs and Medicare Advantage plans, could inadvertently favor or disfavor certain kinds of providers or payers. Such favoritism could drive efficient organizations from the market and thus increase costs or reduce quality of and access to care. To avoid this type of outcome, we propose a general principle: Regulation of ACOs should strive to preserve a level playing field among different kinds of organizations seeking the same cost, quality, and access objectives. This is known as regulatory neutrality. We describe the implications of regulatory neutrality in four key areas: antitrust, financial solvency regulation, Medicare governance requirements, and Medicare payment models. We also discuss issues relating to short-term versus long-term perspectives--to promote the goal of regulatory neutrality and allow the most efficient organizations to prevail in the marketplace.

  11. Dose Assessment in Computed Tomography Examination and Establishment of Local Diagnostic Reference Levels in Mazandaran, Iran

    PubMed Central

    Janbabanezhad Toori, A.; Shabestani-Monfared, A.; Deevband, M.R.; Abdi, R.; Nabahati, M.

    2015-01-01

    Background Medical X-rays are the largest man-made source of public exposure to ionizing radiation. While the benefits of Computed Tomography (CT) are well known in accurate diagnosis, those benefits are not risk-free. CT is a device with higher patient dose in comparison with other conventional radiation procedures. Objective This study is aimed at evaluating radiation dose to patients from Computed Tomography (CT) examination in Mazandaran hospitals and defining diagnostic reference level (DRL). Methods Patient-related data on CT protocol for four common CT examinations including brain, sinus, chest and abdomen & pelvic were collected. In each center, Computed Tomography Dose Index (CTDI) measurements were performed using pencil ionization chamber and CT dosimetry phantom according to AAPM report No. 96 for those techniques. Then, Weighted Computed Tomography Dose Index (CTDIW), Volume Computed Tomography Dose Index (CTDI vol) and Dose Length Product (DLP) were calculated. Results The CTDIw for brain, sinus, chest and abdomen & pelvic ranged (15.6-73), (3.8-25. 8), (4.5-16.3) and (7-16.3), respectively. Values of DLP had a range of (197.4-981), (41.8-184), (131-342.3) and (283.6-486) for brain, sinus, chest and abdomen & pelvic, respectively. The 3rd quartile of CTDIW, derived from dose distribution for each examination is the proposed quantity for DRL. The DRLs of brain, sinus, chest and abdomen & pelvic are measured 59.5, 17, 7.8 and 11 mGy, respectively. Conclusion Results of this study demonstrated large scales of dose for the same examination among different centers. For all examinations, our values were lower than international reference doses. PMID:26688796

  12. "What my Guidance Councillor Should Have Told Me": The Importance of Universal Access and Exposure to Executive-Level Advice

    ERIC Educational Resources Information Center

    Elliott, Catherine; Leck, Joanne; Rockwell, Brittany; Luthy, Michael

    2013-01-01

    Often, knowledge and quality education is reserved for the elite, where there are systemic obstacles to gaining access to today's leaders. Gender and racial inequities in executive-level positions across North America have been a longstanding debate amongst scholars and policy makers. Research has consistently documented that women are…

  13. Competitive interactions between established grasses and woody plant seedlings under elevated CO₂ levels are mediated by soil water availability.

    PubMed

    Manea, A; Leishman, M R

    2015-02-01

    The expansion of woody plants into grasslands has been observed worldwide and is likely to have widespread ecological consequences. One proposal is that woody plant expansion into grasslands is driven in part by the rise in atmospheric CO2 concentrations. We have examined the effect of CO2 concentration on the competitive interactions between established C4 grasses and woody plant seedlings in a model grassland system. Woody plant seedlings were grown in mesocosms together with established C4 grasses in three competition treatments (root competition, shoot competition and root + shoot competition) under ambient and elevated CO2 levels. We found that the growth of the woody plant seedlings was suppressed by competition from grasses, with root and shoot competition having similar competitive effects on growth. In contrast to expectations, woody plant seedling growth was reduced at elevated CO2 levels compared to that at the ambient CO2 level across all competition treatments, with the most plausible explanation being reduced light and soil water availability in the elevated CO2 mesocosms. Reduced light and soil water availability in the elevated CO2 mesocosms was associated with an increased leaf area index of the grasses which offset the reductions in stomatal conductance and increased rainfall interception. The woody plant seedlings also had reduced 'escapability' (stem biomass and stem height) under elevated compared to ambient CO2 levels. Our results suggest that the expansion of woody plants into grasslands in the future will likely be context-dependent, with the establishment success of woody plant seedlings being strongly coupled to the CO2 response of competing grasses and to soil water availability.

  14. HANDBOOK: GUIDANCE ON SETTING PERMIT CONDITIONS AND REPORTING TRIAL BURN RESULTS

    EPA Science Inventory

    This Handbook provides guidance for establishing operational conditions for incinerators. he document provides a means for state and local agencies to achieve a level of consistency in setting permit conditions that will result in establishment of more uniform permit conditions n...

  15. Regulatory guidance document

    SciTech Connect

    1994-05-01

    The Office of Civilian Radioactive Waste Management (OCRWM) Program Management System Manual requires preparation of the OCRWM Regulatory Guidance Document (RGD) that addresses licensing, environmental compliance, and safety and health compliance. The document provides: regulatory compliance policy; guidance to OCRWM organizational elements to ensure a consistent approach when complying with regulatory requirements; strategies to achieve policy objectives; organizational responsibilities for regulatory compliance; guidance with regard to Program compliance oversight; and guidance on the contents of a project-level Regulatory Compliance Plan. The scope of the RGD includes site suitability evaluation, licensing, environmental compliance, and safety and health compliance, in accordance with the direction provided by Section 4.6.3 of the PMS Manual. Site suitability evaluation and regulatory compliance during site characterization are significant activities, particularly with regard to the YW MSA. OCRWM`s evaluation of whether the Yucca Mountain site is suitable for repository development must precede its submittal of a license application to the Nuclear Regulatory Commission (NRC). Accordingly, site suitability evaluation is discussed in Chapter 4, and the general statements of policy regarding site suitability evaluation are discussed in Section 2.1. Although much of the data and analyses may initially be similar, the licensing process is discussed separately in Chapter 5. Environmental compliance is discussed in Chapter 6. Safety and Health compliance is discussed in Chapter 7.

  16. BRC and the concept and establishment of a lower limit for very low-level radioactive wastes

    SciTech Connect

    LeMone, D.V.; Jacobi, L.R. Jr.

    1994-12-31

    Inherent in any discussion or consideration of low-level waste management is the concept of an established lower boundary: the radiometric value below which the waste is no longer considered to be hazardous in a regulatory sense. The most recent attempt to arrive at this value is embodied in a concept known as Below Regulatory Concern (BRC). It was mandated, established, reviewed, and revoked by the Congress through the Nuclear Regulatory Commission (NRC) in a series of actions extending from August 29, 1985, to August 24, 1993. It actually makes absolutely no difference as to whether we refer to this waste as the politically unacceptable BRC, the older de minimis designation, or the informal, international term Exemptable Waste (EW); the concept is the same. We must establish this boundary. The withdrawal of BRC rule making on the federal level has created the potential for developing major problems in nuclear waste in the areas of economic evaluation, engineering design, and remediation. Additionally, it has left such major waste classification categories as Naturally Occurring Radioactive Material (NORM), Accelerator Produced Radioactive Material (NARM), and Class A Low-Level waste without basic foundations. It is recommended that the International Atomic Energy Agency (IAEA) value for Exemptable Waste (1 mrem/yr or 10 microsieverts/yr) be adopted. This figure could be usefully applied for numerous wastes and waste streams, despite the fact that it is four times less than the Environmental Protection Agency (EPA) recommendation and ten times less than the maximum limit originally adopted by the NRC.

  17. Multi-Level Wild Land Fire Fighting Management Support System for an Optimized Guidance of Ground and Air Forces

    NASA Astrophysics Data System (ADS)

    Almer, Alexander; Schnabel, Thomas; Perko, Roland; Raggam, Johann; Köfler, Armin; Feischl, Richard

    2016-04-01

    -fighting missions. The ongoing development focuses on the following topics: (1) Development of a multi-level management solution to coordinate and guide different airborne and terrestrial deployed firefighting modules as well as related data processing and data distribution activities. (2) Further, a targeted control of the thermal sensor based on a rotating mirror system to extend the "area performance" (covered area per hour) in time critical situations for the monitoring requirements during forest fire events. (3) Novel computer vision methods for analysis of thermal sensor signatures, which allow an automatic classification of different forest fire types and situations. (4) A module for simulation-based decision support for planning and evaluation of resource usage and the effectiveness of performed fire-fighting measures. (5) Integration of wearable systems to assist ground teams in rescue operations as well as a mobile information system into innovative command and fire-fighting vehicles. In addition, the paper gives an outlook on future perspectives including a first concept for the integration of the near real-time multilevel forest fire fighting management system into an "EU Civil Protection Team" to support the EU civil protection modules and the Emergency Response Coordination Centre in Brussels. Keywords: Airborne sensing, multi sensor imaging, near real-time fire monitoring, simulation-based decision support, forest firefighting management, firefighting impact analysis.

  18. Use of random Martian atmosphere to evaluate potential entry guidance schemes

    NASA Technical Reports Server (NTRS)

    Tomlinson, Barbara S.; Suit, William T.

    1990-01-01

    A random Martian atmosphere was developed and was used with three guidance schemes to determine the effect of random density variations on the guidance. This random atmosphere was shown to be useful for testing the robustness of guidance schemes for vehicles encountering random disturbances during aerobraking for capture into planetary orbit. Levels of disturbance that could be tolerated and areas where performance could be improved were established. The need for Monte Carlo studies to define the excursion boundaries of capture orbit parameters was indicated.

  19. Information architecture. Volume 3: Guidance

    SciTech Connect

    1997-04-01

    The purpose of this document, as presented in Volume 1, The Foundations, is to assist the Department of Energy (DOE) in developing and promulgating information architecture guidance. This guidance is aimed at increasing the development of information architecture as a Departmentwide management best practice. This document describes departmental information architecture principles and minimum design characteristics for systems and infrastructures within the DOE Information Architecture Conceptual Model, and establishes a Departmentwide standards-based architecture program. The publication of this document fulfills the commitment to address guiding principles, promote standard architectural practices, and provide technical guidance. This document guides the transition from the baseline or defacto Departmental architecture through approved information management program plans and budgets to the future vision architecture. This document also represents another major step toward establishing a well-organized, logical foundation for the DOE information architecture.

  20. 40 CFR Table 7 to Subpart Ppp of... - Operating Parameters for Which Monitoring Levels Are Required To Be Established for Process Vent...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Monitoring Levels Are Required To Be Established for Process Vent Streams 7 Table 7 to Subpart PPP of Part 63... Established for Process Vent Streams Control technique Parameters to be monitored Established operating... regeneration stream mass or volumetric flow during carbon bed regeneration cycle; and temperature of the...

  1. 76 FR 79689 - Agency Information Collection Activities; Proposed Collection; Comment Request; Guidance for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-22

    ... Collection; Comment Request; Guidance for Clinical Trial Sponsors: Establishment and Operation of Clinical... information concerning the establishment and operation of clinical trial data monitoring committees. DATES... of information technology. Guidance for Clinical Trial Sponsors: Establishment and Operation...

  2. Volatile halocarbons in butter: elevated tetrachloroethylene levels in samples obtained in close proximity to dry-cleaning establishments

    SciTech Connect

    Miller, L.J.; Uhler, A.D.

    1988-09-01

    In recent years materials not directly associated with food production, such as polychlorinated and brominated biphenyls, have been found in foods. According to the criteria to evaluate the likelihood for a chemical to contaminate food, the volatile halocarbons (VHCs) were selected as target compounds in an examination for potential contaminants in selected foods. The technique of multiple headspace extraction (MHE) was used in this study to minimize sample handling, and thereby reduce the potential for laboratory contamination and maximize throughput. Recently this laboratory reported findings of several VHCs in margarine, including PCE in four samples at levels above the usual background findings. Those samples had been obtained from a food store located immediately next to a dry-cleaning establishment. Follow-up investigation was conducted to determine the frequency of occurrence and levels of PCE that may be present in fatty foods purchased from stores located both near and distant from dry cleaners. Butter was chosen as a model food because it is a highly uniform product of very high fat content, which would be expected to act as a good absorber of the lipophilic VHCs. This paper presents results of these analyses and correlations between level of VHCs in butter and the proximity to dry cleaners of the food store where the butter was purchased.

  3. Guidelines for a Quality Career Guidance Program.

    ERIC Educational Resources Information Center

    Vocational Guidance Quarterly, 1979

    1979-01-01

    This position paper on quality career guidance programs outlines basic assumptions, guidelines, a comprehensive program development model, and recommended uses. Highlights of the program development model include management questions, information, and program standards. This represents NVGA/AVA Guidance Divisions efforts to establish standards for…

  4. Establishing the "Biological Relevance" of Dipentyl Phthalate Reductions in Fetal Rat Testosterone Production and Plasma and Testis Testosterone Levels.

    PubMed

    Gray, Leon Earl; Furr, Johnathan; Tatum-Gibbs, Katoria R; Lambright, Christy; Sampson, Hunter; Hannas, Bethany R; Wilson, Vickie S; Hotchkiss, Andrew; Foster, Paul M D

    2016-01-01

    Phthalate esters (PEs) constitute a large class of compounds that are used for many consumer product applications. Many of the C2-C7 di-ortho PEs reduce fetal testicular hormone and gene expression levels in rats resulting in adverse effects seen later in life but it appears that relatively large reductions in fetal testosterone (T) levels and testis gene expression may be required to adversely affect reproductive development (Hannas, B. R., Lambright, C. S., Furr, J., Evans, N., Foster, P. M., Gray, E. L., and Wilson, V. S. (2012). Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency. Toxicol. Sci. 125, 544-557). The objectives of this study were (1) to model the relationships between changes in fetal male rat plasma testosterone (PT), T levels in the testis (TT), T production (PROD), and testis gene expression with the reproductive malformation rates, and (2) to quantify the "biologically relevant reductions" (BRRs) in fetal T necessary to induce adverse effects in the offspring. In the fetal experiment, Harlan Sprague-Dawley rats were dosed with dipentyl phthalate (DPeP) at 0, 11, 33, 100, and 300 mg/kg/day from gestational days (GD) 14-18 and fetal testicular T, PT levels, and T Prod and gene expression were assessed on GD 18. In the postnatal experiment, rats were dosed with DPeP from GD 8-18 and reproductive development was monitored through adulthood. The dose-response curves for TT levels (ED(50) = 53 mg/kg) and T PROD (ED(50) = 45 mg/kg) were similar, whereas PT was reduced at ED50 = 19 mg/kg. When the reductions in TPROD and Insl3 mRNA were compared with the postnatal effects of in utero DPeP, dose-related reproductive alterations were noted when T PROD and Insl3 mRNA were reduced by >45% and 42%, respectively. The determination of BRR levels may enable risk assessors to utilize fetal endocrine data to help establish points of departure for

  5. Establishment of a structural equation model for ground-level ozone: a case study at an urban roadside site.

    PubMed

    Lin, Kun-Ming; Yu, Tai-Yi; Chang, Len-Fu

    2014-12-01

    This study established a cause-effect relationship between ground-level ozone and latent variables employing partial least-squares analysis at an urban roadside site in four distinct seasons. Two multivariate analytic methods, factor analysis, and cluster analysis were adopted to cite and identify suitable latent variables from 14 observed variables (i.e., meteorological factors, wind and primary air pollutants) in 2008-2010. Analytical results showed that the first six components explained 80.3 % of the variance, and eigenvalues of the first four components were greater than 1. The effectiveness of this model was empirically confirmed with three indicators. Except for surface pressure, factor loadings of observed variables were 0.303-0.910 and reached statistical significance at the 5 % level. Composite reliabilities for latent variables were 0.672-0.812 and average variances were 0.404-0.547, except for latent variable "primary" in spring; thus, discriminant validity and convergent validity were marginally accepted. The developed model is suitable for the assessment of urban roadside surface ozone, considering interactions among meteorological factors, wind factors, and primary air pollutants in each season.

  6. How navigational guidance systems are combined in a desert ant.

    PubMed

    Collett, Matthew

    2012-05-22

    Animals use information from multiple sources in order to navigate between goals. Ants such as Cataglyphis fortis use an odometer and a sun-based compass to provide input for path integration (PI). They also use configurations of visual features to learn both goal locations and habitual routes to the goals. Information is not combined into a unified representation but appears to be exploited by separate expert guidance systems. Visual and PI goal memories are acquired rapidly and provide the consistency for route memories to be formed. Do established route memories then suppress the guidance from PI? A series of manipulations putting PI and route memories into varying levels of conflict found that ants follow compromise trajectories. The guidance systems are therefore active together and share the control of behavior. Route memories do not suppress the other guidance systems. A simple model shows that observed patterns of control could arise from a superposition of the output commands from the guidance systems, potentially approximating Bayesian inference. These results help show how an insect's relatively simple decision-making can produce navigation that is reliable and efficient and that also adapts to changing demands.

  7. Guidance and Counselling: What Is the Level of Human and Physical Resource Preparedness in Providing Effective Services in Secondary Schools in Bureti Sub County, Kericho County, Kenya?

    ERIC Educational Resources Information Center

    Cheruiyot, David Kipkorir; Orodho, John Aluko

    2015-01-01

    The gist of this study was to examine the human and resource preparedness to provide effective guidance and counselling (G&C) services in secondary schools in Bureti Sub County, Kericho County, Kenya. The study used combinations of descriptive survey and correlation research designs. Stratified sampling technique was employed to select 20…

  8. Assessing baseline levels of coral health in a newly established marine protected area in a global scuba diving hotspot.

    PubMed

    Hein, Margaux Y; Lamb, Joleah B; Scott, Chad; Willis, Bette L

    2015-02-01

    While coral reefs are increasingly threatened worldwide, they are also increasingly used for recreational activities. Given the environmental and socio-economic significance of coral reefs, understanding the links between human activities and coral health and evaluating the efficacy of marine protected areas (MPAs) as a management regime to prevent further deterioration are critically important. The aim of this study was to quantify indicators of coral health at sites inside and outside a newly rezoned MPA framework in the dive tourism hotspot of Koh Tao, Thailand. We found that patterns in the health and diversity of coral communities one year on did not reflect the protected status conferred by newly zoned MPAs, but instead reflected past history of recreational use around the island. Sites characterised as past high-use sites had lower mean percent cover of hard corals overall and of corals in the typically disease- and disturbance-susceptible family Acroporidae, but higher mean cover of species in the more weedy family Agariciidae. Past high use sites also had higher mean prevalence of infectious diseases and other indicators of compromised health. Sites within the newly established MPAs are currently subjected to higher levels of environmental and anthropogenic pressures, with sedimentation, algal overgrowth, feeding scars from Drupella snails, and breakage particularly prevalent compared to sites in non-MPA areas. Given the greater prevalence of these factors within protected sites, the capacity of the MPA framework to effectively prevent further deterioration of Koh Tao's reefs is unclear. Nevertheless, our study constitutes a strong baseline for future long-term evaluations of the potential of MPAs to maintain coral health and diversity on highly threatened reefs. PMID:25460062

  9. Assessing baseline levels of coral health in a newly established marine protected area in a global scuba diving hotspot.

    PubMed

    Hein, Margaux Y; Lamb, Joleah B; Scott, Chad; Willis, Bette L

    2015-02-01

    While coral reefs are increasingly threatened worldwide, they are also increasingly used for recreational activities. Given the environmental and socio-economic significance of coral reefs, understanding the links between human activities and coral health and evaluating the efficacy of marine protected areas (MPAs) as a management regime to prevent further deterioration are critically important. The aim of this study was to quantify indicators of coral health at sites inside and outside a newly rezoned MPA framework in the dive tourism hotspot of Koh Tao, Thailand. We found that patterns in the health and diversity of coral communities one year on did not reflect the protected status conferred by newly zoned MPAs, but instead reflected past history of recreational use around the island. Sites characterised as past high-use sites had lower mean percent cover of hard corals overall and of corals in the typically disease- and disturbance-susceptible family Acroporidae, but higher mean cover of species in the more weedy family Agariciidae. Past high use sites also had higher mean prevalence of infectious diseases and other indicators of compromised health. Sites within the newly established MPAs are currently subjected to higher levels of environmental and anthropogenic pressures, with sedimentation, algal overgrowth, feeding scars from Drupella snails, and breakage particularly prevalent compared to sites in non-MPA areas. Given the greater prevalence of these factors within protected sites, the capacity of the MPA framework to effectively prevent further deterioration of Koh Tao's reefs is unclear. Nevertheless, our study constitutes a strong baseline for future long-term evaluations of the potential of MPAs to maintain coral health and diversity on highly threatened reefs.

  10. Unified powered flight guidance

    NASA Technical Reports Server (NTRS)

    Brand, T. J.; Brown, D. W.; Higgins, J. P.

    1973-01-01

    A complete revision of the orbiter powered flight guidance scheme is presented. A unified approach to powered flight guidance was taken to accommodate all phases of exo-atmospheric orbiter powered flight, from ascent through deorbit. The guidance scheme was changed from the previous modified version of the Lambert Aim Point Maneuver Mode used in Apollo to one that employs linear tangent guidance concepts. This document replaces the previous ascent phase equation document.

  11. Pan-Eurasian experiment (PEEX) establishing a process towards high level Pan-Eurasian atmosphere-ecosystem observation networks

    NASA Astrophysics Data System (ADS)

    Lappalainen, Hanna K.; Petäjä, Tuukka; Zaytzeva, Nina; Viisanen, Yrjö; Kotlyakov, Vladimir; Kasimov, Nikolay; Bondur, Valery; Matvienko, Gennady; Zilitinkevich, Sergej; Kulmala, Markku

    2014-05-01

    Pan-Eurasian Experiment (PEEX) is a new multidisciplinary research approach aiming at resolving the major uncertainties in the Earth system science and global sustainability questions in the Arctic and boreal Pan-Eurasian regions (Kulmala et al. 2011). The main goal of PEEX Research agenda is to contribute to solving the scientific questions that are specifically important for the Pan-Eurasian region in the coming years, in particular the global climate change and its consequences to nature and human society. Pan Eurasian region represents one the Earth most extensive areas of boreal forest (taiga) and the largest natural wetlands, thus being a significant source area of trace gas emissions, biogenic aerosol particles, and source and sink area for the greenhouse gas (GHG) exchange in a global scale (Guenther et al. 1995, Timkovsky et al. 2010, Tunved et al. 2006, Glagolev et al. 2010). One of the first activities of the PEEX initiative is to establish a process towards high level Pan-Eurasian Observation Networks. Siberian region is currently lacking a coordinated, coherent ground based atmosphere-ecosystem measurement network, which would be crucial component for observing and predicting the effects of climate change in the Northern Pan- Eurasian region The vision of the Pan-Eurasion network will be based on a hierarchical SMEAR-type (Stations Measuring Atmosphere-Ecosystem Interactions) integrated land-atmosphere observation system (Hari et al. 2009). A suite of stations have been selected for the Preliminary Phase of PEEX Observation network. These Preliminary Phase stations includes the SMEAR-type stations in Finland (SMEAR-I-II-II-IV stations), in Estonia (SMEAR-Järviselja) and in China (SMEAR-Nanjing) and selected stations in Russia and ecosystem station network in China. PEEX observation network will fill in the current observational gap in the Siberian region and bring the Siberian observation setup into international context with the with standardized or

  12. Project Inspire: Vocational Guidance Institute.

    ERIC Educational Resources Information Center

    National Alliance of Businessmen, Washington, DC.

    Two introductory speeches suggest the general social and interracial climate in the United States. It is against this backdrop that Project Inspire is described. Its purpose is the development of a vocational guidance component within the broader school curriculum. Its major objective is elevating the awareness level of students to the work world…

  13. Career Guidance and Public Mental Health

    ERIC Educational Resources Information Center

    Robertson, Peter J.

    2013-01-01

    Career guidance may have the potential to promote public health by contributing positively to both the prevention of mental health conditions and to population level well-being. The policy implications of this possibility have received little attention. Career guidance agencies are well placed to reach key target groups. Producing persuasive…

  14. The guidance system for Ariane

    NASA Astrophysics Data System (ADS)

    Angus, Alex M.; Gordon, Colin S.; Brunschvig, Alain

    1991-05-01

    The various subsystems that comprise the complete Ariane guidance system are described along with a brief background of earlier developmental instruments and their applications. The Centrale Inertielle is a part of the control and guidance system of the Ariane launcher whose function is to provide a space-stable datum allowing measurement of acceleration and attitude relative to that datum. Consideration is given to the inertial platform, the electronics unit, thermal requirements, coarse alignment and fine-leveling, and the Vehicle Equipment Bay (VEB). The VEB is the main component of the electrical system and is designed to support all the equipment handling the following functions: guidance, navigation and control, sequencer and pyro management, localization and safety management, and telemetry.

  15. Endangerment assessment guidance

    SciTech Connect

    Not Available

    1985-11-22

    The directive clarifies the requirement that an endangerment assessment be developed to support all administrative and judicial enforcement actions under Section 106 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and Section 7003 of the Resource Conservation and Recovery Act (RCRA). Before taking enforcement action under these provisions to abate the hazards or potential hazards at a site, the Environmental Protection Agency (EPA) must be able to properly document and justify its assertion that an imminent and substantial endangerment to public health or welfare or the environment may exist. The endangerment assessment provides this documentation and justification. The endangerment assessment is not necessary to support Section 104 actions. It also provides guidance on the content, timing, level of detail, format, and resources required for the preparation of endangerment assessments.

  16. Mobile Robot Guidance By Visual Perception

    NASA Astrophysics Data System (ADS)

    Llario, V.; Martinez, A.; Montseny, E.

    1986-06-01

    Guidance of autonomons transport systems used in flexible manufacturing systems is usually performed by using either photoelectric cells or leading wires. This work refer to the system developped to track painted strips on the floor by means of a TV camera. The system designed is able to recognize and identify a pattern on the floor in a factory environment and to deal with the guidance of a transport system according to the commands received from the control unit which establishes its itinerary.

  17. 77 FR 40068 - Draft Guidance for Industry: Recommendations for Donor Questioning, Deferral, Reentry, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... Questioning, Deferral, Reentry, and Product Management To Reduce the Risk of Transfusion-Transmitted Malaria...-Transmitted Malaria'' dated June 2012. The draft guidance document provides blood establishments that collect... malaria. This guidance replaces the draft guidance entitled ``Guidance for Industry: Recommendations...

  18. Commercial radioactive waste minimization program development guidance

    SciTech Connect

    Fischer, D.K.

    1991-01-01

    This document is one of two prepared by the EG&G Idaho, Inc., Waste Management Technical Support Program Group, National Low-Level Waste Management Program Unit. One of several Department of Energy responsibilities stated in the Amendments Act of 1985 is to provide technical assistance to compact regions Host States, and nonmember States (to the extent provided in appropriations acts) in establishing waste minimization program plans. Technical assistance includes, among other things, the development of technical guidelines for volume reduction options. Pursuant to this defined responsibility, the Department of Energy (through EG&G Idaho, Inc.) has prepared this report, which includes guidance on defining a program, State/compact commission participation, and waste minimization program plans.

  19. Commercial radioactive waste minimization program development guidance

    SciTech Connect

    Fischer, D.K.

    1991-01-01

    This document is one of two prepared by the EG G Idaho, Inc., Waste Management Technical Support Program Group, National Low-Level Waste Management Program Unit. One of several Department of Energy responsibilities stated in the Amendments Act of 1985 is to provide technical assistance to compact regions Host States, and nonmember States (to the extent provided in appropriations acts) in establishing waste minimization program plans. Technical assistance includes, among other things, the development of technical guidelines for volume reduction options. Pursuant to this defined responsibility, the Department of Energy (through EG G Idaho, Inc.) has prepared this report, which includes guidance on defining a program, State/compact commission participation, and waste minimization program plans.

  20. OECD Review of Career Guidance Policies. Australia: Country Note.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France).

    Australia's career guidance system and policies were evaluated. The review team met with policymakers and guidance practitioners in four states and at the national level, conducted site visits to various career guidance providers in the public and private sectors, analyzed data from a national questionnaire, and reviewed pertinent documentation.…

  1. NEW PROGRAMS AND TRENDS IN GUIDANCE FOR SOCIALLY DISADVANTAGED YOUTH.

    ERIC Educational Resources Information Center

    MOORE, JAMES W.

    THE BUREAU OF GUIDANCE OF THE NEW YORK STATE EDUCATION DEPARTMENT INITIATES DEMONSTRATION GUIDANCE PROJECTS FOR DISADVANTAGED STUDENTS WHICH ARE CONDUCTED THROUGHOUT THE STATE. PROPOSALS FOR THESE PROJECTS ARE SUBMITTED BY THE LOCAL SCHOOL DISTRICTS BECAUSE GUIDANCE AND EDUCATIONAL PROJECTS CONDUCTED AT THIS LEVEL ARE MOST PROMISING. PROJECT ABLE…

  2. Derivation of beryllium guidelines for use in establishing cleanup levels at the Peek Street and Sacandaga sites, New York

    SciTech Connect

    Hartmann, H.M.; Avci, H.I.; Ditmars, J.D.

    1992-02-01

    Guideline levels are derived for beryllium in soil and on indoor surfaces at the Peek Street and Sacandaga sites in the state of New York. On the basis of highly conservative assumptions, the soil beryllium concentration that corresponds to a 10{sup {minus} 4} carcinogenic risk level is estimated to be 13 mg/kg at both sites. Calculations indicate that the proposed US Department of Energy guideline of 2 {mu}g/ft{sup 2} for beryllium in dust on indoor surfaces would be sufficiently protective of human health. For occupational protection of workers during cleanup operations, Office of Safety and Health Administration standards for beryllium are referenced and restated.

  3. Premise to Implement a Grading System to Evaluate the Sanitary Level in Food Service Establishments in Milan, Italy

    PubMed Central

    Razzini, Katia

    2015-01-01

    The regulatory framework of the official controls on food safety, the criteria and methods from the planning of interventions in the field of official control to the management of information flows, and the standards described in the operation manual of the local competent authorities drafted by the Lombardy Region (2011) were evaluated. A questionnaire consisting of n. 10 questions with multiple answers draft in partnership with EPAM (the Association of Provincial Public Retail and catering businesses in Milan) to n. 107 Food service establishments of Milan shows that 92% of managers approve the introduction of a grading system. The regulatory framework is planned to support the implementation of risk assignment, unfortunately the attribution of risk category of retail and catering businesses is still different among regions. PMID:27800403

  4. 41 CFR 102-80.115 - Is there more than one option for establishing that an equivalent level of safety exists?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL... Equivalent Level of Safety Analysis § 102-80.115 Is there more than one option for establishing that an... areas of safety. Available safe egress times would be developed based on analysis of a number of...

  5. 41 CFR 102-80.115 - Is there more than one option for establishing that an equivalent level of safety exists?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL... Equivalent Level of Safety Analysis § 102-80.115 Is there more than one option for establishing that an... areas of safety. Available safe egress times would be developed based on analysis of a number of...

  6. Establishing the Biological Relevance of Dipentyl Phthalate Reductions in Fetal Rat Testosterone Production and Plasma and Testis Testosterone Levels

    EPA Science Inventory

    Phthalate esters (PEs) constitute a large class of compounds that are used for many consumer product applications. Many of the C2-C7 di-ortho PEs reduce fetal testicular hormone and gene expression levels in rats resulting in adverse effects seen later in life but it appears that...

  7. Aiding Vertical Guidance Understanding

    NASA Technical Reports Server (NTRS)

    Feary, Michael; McCrobie, Daniel; Alkin, Martin; Sherry, Lance; Polson, Peter; Palmer, Everett; McQuinn, Noreen

    1998-01-01

    A two-part study was conducted to evaluate modern flight deck automation and interfaces. In the first part, a survey was performed to validate the existence of automation surprises with current pilots. Results indicated that pilots were often surprised by the behavior of the automation. There were several surprises that were reported more frequently than others. An experimental study was then performed to evaluate (1) the reduction of automation surprises through training specifically for the vertical guidance logic, and (2) a new display that describes the flight guidance in terms of aircraft behaviors instead of control modes. The study was performed in a simulator that was used to run a complete flight with actual airline pilots. Three groups were used to evaluate the guidance display and training. In the training, condition, participants went through a training program for vertical guidance before flying the simulation. In the display condition, participants ran through the same training program and then flew the experimental scenario with the new Guidance-Flight Mode Annunciator (G-FMA). Results showed improved pilot performance when given training specifically for the vertical guidance logic and greater improvements when given the training and the new G-FMA. Using actual behavior of the avionics to design pilot training and FMA is feasible, and when the automated vertical guidance mode of the Flight Management System is engaged, the display of the guidance mode and targets yields improved pilot performance.

  8. Guidance for Total Development.

    ERIC Educational Resources Information Center

    Van Hoose, William H.

    Elementary guidance, deriving much of its content from the developmental phenomena of middle childhood, is viewed as the maximization of human potentiality in the total range of the population. Included in the list of elementary school guidance objectives are (1) aiding academic development, (2) helping children develop health self-concepts, (3)…

  9. Guidance for performing preliminary assessments under CERCLA

    SciTech Connect

    1991-09-01

    EPA headquarters and a national site assessment workgroup produced this guidance for Regional, State, and contractor staff who manage or perform preliminary assessments (PAs). EPA has focused this guidance on the types of sites and site conditions most commonly encountered. The PA approach described in this guidance is generally applicable to a wide variety of sites. However, because of the variability among sites, the amount of information available, and the level of investigative effort required, it is not possible to provide guidance that is equally applicable to all sites. PA investigators should recognize this and be aware that variation from this guidance may be necessary for some sites, particularly for PAs performed at Federal facilities, PAs conducted under EPA`s Environmental Priorities Initiative (EPI), and PAs at sites that have previously been extensively investigated by EPA or others. The purpose of this guidance is to provide instructions for conducting a PA and reporting results. This guidance discusses the information required to evaluate a site and how to obtain it, how to score a site, and reporting requirements. This document also provides guidelines and instruction on PA evaluation, scoring, and the use of standard PA scoresheets. The overall goal of this guidance is to assist PA investigators in conducting high-quality assessments that result in correct site screening or further action recommendations on a nationally consistent basis.

  10. Establishing the level of digitization for wrist and hand radiographs for the third National Health and Nutrition Examination Survey.

    PubMed

    Ostchega, Y; Long, L R; Goh, G H; Hirsch, R; Ma, L D; Scott, W W; Johnson, W; Thoma, G R

    1998-08-01

    In the third National Health and Nutrition Examination Survey (NHANES III) conducted by the National Center for Health Statistics, Centers for Disease Control and Prevention, radiographs of the hands and knees were taken of participants 60 years and older as part of the study of arthritis and musculoskeletal conditions. The purpose of the study was to decide the digitizing resolution to be used for these radiographs. A set of wrist and hand radiographs (N = 49) was graded by two radiologists for degree of bone erosions and served as a "gold standard." The radiographs were then digitized at three resolution levels; low-resolution 150 microns (2001 x 1634 x 12 bit matrix); intermediate-resolution 100 microns (3000 x 2400 x 12 bit matrix); and high-resolution 50 microns (4900 x 3000 x 12 bit matrix). A comparison of the digital images versus the gold standard reading was made at the three resolutions by two radiologists. Kappa statistics suggested fair (K > .4) to excellent (K > .75) agreement between the gold standard and the images at all levels. Intraclass correlation coefficient suggested high agreement between readers (ICC > .5), with minimal individual reader effect. Variance component estimates showed that the major contribution (78-83%) to scoring came from variability in the images themselves, not from the readers. The 100 microns resolution was selected over the 150 and 50 microns on the basis of practical considerations such as storage requirements, display time, and easier manipulation of the digital images by the readers.

  11. Writing Seveso II safety reports: new EU guidance reflecting 5 years' experience with the Directive.

    PubMed

    Wood, Maureen Heraty; Fabbri, Luciano; Struckl, Michael

    2008-09-15

    Since the coming into force of the Seveso II Directive, considerable experience has been acquired in regard to preparation of safety reports for establishments that fall under the requirements of this Directive. In light of this experience, the Amendment of the Seveso II Directive adopted by the European Parliament and the Council on 16 December 2003, gave the European Commission the mandate "to review by 31 December 2006 in close cooperation with the Member States, the existing Guidance on the Preparation of a safety report (EUR 17690)". As a result, a technical working group of Member States representing the Seveso competent authorities and the European Commission's Major Accident Hazards Bureau was established to review and re-examine the guidance. The new guidance maintains the high-level and overarching character of the older version, but improves the document through better definition of conceptual elements of the safety report and greater alignment with Annex II of the Directive, which describes the essential elements of the safety report. This paper describes the new guidance in terms of its contribution to developing a harmonized conceptual framework for preparing and reviewing safety reports within the context of Seveso II implementation. Overall, the aim of the guidance is to provide concrete advice to operators and competent authorities on the logic and expectations underlying the safety report, so as to make both preparation and review of the report a more efficient and useful exercise for all parties involved. PMID:18276071

  12. Establishing a synthetic pathway for high-level production of 3-hydroxypropionic acid in Saccharomyces cerevisiae via β-alanine.

    PubMed

    Borodina, Irina; Kildegaard, Kanchana R; Jensen, Niels B; Blicher, Thomas H; Maury, Jérôme; Sherstyk, Svetlana; Schneider, Konstantin; Lamosa, Pedro; Herrgård, Markus J; Rosenstand, Inger; Öberg, Fredrik; Forster, Jochen; Nielsen, Jens

    2015-01-01

    Microbial fermentation of renewable feedstocks into plastic monomers can decrease our fossil dependence and reduce global CO2 emissions. 3-Hydroxypropionic acid (3HP) is a potential chemical building block for sustainable production of superabsorbent polymers and acrylic plastics. With the objective of developing Saccharomyces cerevisiae as an efficient cell factory for high-level production of 3HP, we identified the β-alanine biosynthetic route as the most economically attractive according to the metabolic modeling. We engineered and optimized a synthetic pathway for de novo biosynthesis of β-alanine and its subsequent conversion into 3HP using a novel β-alanine-pyruvate aminotransferase discovered in Bacillus cereus. The final strain produced 3HP at a titer of 13.7±0.3gL(-1) with a 0.14±0.0C-molC-mol(-1) yield on glucose in 80h in controlled fed-batch fermentation in mineral medium at pH 5, and this work therefore lays the basis for developing a process for biological 3HP production.

  13. Survey of computed tomography doses and establishment of national diagnostic reference levels in the Republic of Belarus.

    PubMed

    Kharuzhyk, S A; Matskevich, S A; Filjustin, A E; Bogushevich, E V; Ugolkova, S A

    2010-01-01

    Computed tomography dose index (CTDI) was measured on eight CT scanners at seven public hospitals in the Republic of Belarus. The effective dose was calculated using normalised values of effective dose per dose-length product (DLP) over various body regions. Considerable variations of the dose values were observed. Mean effective doses amounted to 1.4 +/- 0.4 mSv for brain, 2.6 +/- 1.0 mSv for neck, 6.9 +/- 2.2 mSv for thorax, 7.0 +/- 2.3 mSv for abdomen and 8.8 +/- 3.2 mSv for pelvis. Diagnostic reference levels (DRLs) were proposed by calculating the third quartiles of dose value distributions (body region/volume CTDI, mGy/DLP, mGy cm): brain/60/730, neck/55/640, thorax/20/500, abdomen/25/600 and pelvis/25/490. It is evident that the protocols need to be optimised on some of the CT scanners, in view of the fact that these are the first formulated DRLs for the Republic of Belarus.

  14. Establishing a synthetic pathway for high-level production of 3-hydroxypropionic acid in Saccharomyces cerevisiae via β-alanine.

    PubMed

    Borodina, Irina; Kildegaard, Kanchana R; Jensen, Niels B; Blicher, Thomas H; Maury, Jérôme; Sherstyk, Svetlana; Schneider, Konstantin; Lamosa, Pedro; Herrgård, Markus J; Rosenstand, Inger; Öberg, Fredrik; Forster, Jochen; Nielsen, Jens

    2015-01-01

    Microbial fermentation of renewable feedstocks into plastic monomers can decrease our fossil dependence and reduce global CO2 emissions. 3-Hydroxypropionic acid (3HP) is a potential chemical building block for sustainable production of superabsorbent polymers and acrylic plastics. With the objective of developing Saccharomyces cerevisiae as an efficient cell factory for high-level production of 3HP, we identified the β-alanine biosynthetic route as the most economically attractive according to the metabolic modeling. We engineered and optimized a synthetic pathway for de novo biosynthesis of β-alanine and its subsequent conversion into 3HP using a novel β-alanine-pyruvate aminotransferase discovered in Bacillus cereus. The final strain produced 3HP at a titer of 13.7±0.3gL(-1) with a 0.14±0.0C-molC-mol(-1) yield on glucose in 80h in controlled fed-batch fermentation in mineral medium at pH 5, and this work therefore lays the basis for developing a process for biological 3HP production. PMID:25447643

  15. Interactions between teacher guidance and contingent access to play in developing preacademic skills of deviant preschool children.

    PubMed Central

    Rowbury, T G; Baer, A M; Baer, D M

    1976-01-01

    Token-mediated access to play and snacks was made contingent on completion of academic tasks in the Baseline Experiment. This contingency produced stable completion rates that were subsequently doubled, and then tripled, for four deviant children in a special preschool. A reversal design demonstrated that the contingency was functional in maintaining the children's rates of task completion. The Guidance Experiment examined the role of a social event, teacher guidance, in the acquisition of task-completion skills, in a multiple-baseline-across-tasks design (with reversals). The analysis demonstrated that teacher guidance was an important supplement to the token-mediated contingency in establishing significant increases in task completions for a second group of three deviant children in the special class. The importance of teacher guidance was related to the difficulty level of the children's tasks. PMID:1254543

  16. Interactions between teacher guidance and contingent access to play in developing preacademic skills of deviant preschool children.

    PubMed

    Rowbury, T G; Baer, A M; Baer, D M

    1976-01-01

    Token-mediated access to play and snacks was made contingent on completion of academic tasks in the Baseline Experiment. This contingency produced stable completion rates that were subsequently doubled, and then tripled, for four deviant children in a special preschool. A reversal design demonstrated that the contingency was functional in maintaining the children's rates of task completion. The Guidance Experiment examined the role of a social event, teacher guidance, in the acquisition of task-completion skills, in a multiple-baseline-across-tasks design (with reversals). The analysis demonstrated that teacher guidance was an important supplement to the token-mediated contingency in establishing significant increases in task completions for a second group of three deviant children in the special class. The importance of teacher guidance was related to the difficulty level of the children's tasks.

  17. Optical guidance vidicon test program

    NASA Technical Reports Server (NTRS)

    Eiseman, A. R.; Stanton, R. H.; Voge, C. C.

    1976-01-01

    A laboratory and field test program was conducted to quantify the optical navigation parameters of the Mariner vidicons. A scene simulator and a camera were designed and built for vidicon tests under a wide variety of conditions. Laboratory tests characterized error sources important to the optical navigation process and field tests verified star sensitivity and characterized comet optical guidance parameters. The equipment, tests and data reduction techniques used are described. Key test results are listed. A substantial increase in the understanding of the use of selenium vidicons as detectors for spacecraft optical guidance was achieved, indicating a reduction in residual offset errors by a factor of two to four to the single pixel level.

  18. Review of soil contamination guidance

    SciTech Connect

    Mueller, M.A.; Kennedy, W.E. Jr.; Soldat, J.K.

    1981-08-01

    A review of existing and proposed radioactive soil contamination standards and guidance was conducted for United Nuclear Corporation (UNC), Office of Surplus Facilities Management. Information was obtained from both government agencies and other sources during a literature survey. The more applicable standards were reviewed, evaluated, and summarized. Information pertaining to soil contamination for both facility operation and facility decommissioning was obtained from a variety of sources. These sources included: the Code of Federal Regulations, regulatory guides, the Federal Register, topical reports written by various government agencies, topical reports written by national laboratories, and publications from the American National Standards Institute (ANSI). It was difficult to directly compare the standards and guidance obtained from these sources since each was intended for a specific situation and different units or bases were used. However, most of the information reviewed was consistent with the philosophy of maintaining exposures at levels as low as reasonably achievable (ALARA).

  19. Hybrid guidance for maneuvering flight vehicles

    NASA Astrophysics Data System (ADS)

    Ling, Dehai

    1992-02-01

    This article puts forward one type of guidance option related to the maneuver programming of reentering flight vehicles. The option in question makes use of a radiation sensing system, precisely determining the location of the starting point of the reentering flight vehicle. Use is also made of strap-on type inertial guidance systems to control the impact points of flight vehicles. Maneuvering flight is an important direction in the development of the technology of strategic flight vehicles. It is possible to use it in sudden defense, adding programming, raising precision, and recovery. Maneuvering flight tests are capable of giving complete checks in all such areas as flight vehicle propulsion systems, materials structure, heat resistance systems, stability, guidance circuits, and attitude control systems. It is capable of carrying out experiments on different technological levels. Options which are relatively simple and easy to carry out are to make the reentering flight vehicle, within the longitudinal plane, fly maneuvers according to preset programs. Going through precise inertial guidance or celestial-inertial guidance systems, guidance is carried out on the flight vehicle in the main power stage, with controls and corrections to the free section flight orbital plane, such that the trajectory is capable of entering into the predicted reentry corridor. As far as initial flight tests are concerned, it is possible to make use of inertial guidance systems which already exist, relaxing the requirements for launch plane controls and lateral impact point deviations.

  20. A Workable Program of Career Guidance

    ERIC Educational Resources Information Center

    Hunt, Myrtle E.

    1974-01-01

    Seven observations made by a career education team (a counselor, an occupational specialist, and classroom teachers) provided the basis for establishing career guidance goals. The goals were devoloped around the accepted elements of career education and implemented in a teacher-counselor shared accountability effort in Florida's Pinellas County.…

  1. 76 FR 20992 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ...; Class II Special Controls Guidance Document: Low Level Laser System for Aesthetic Use; Availability...: Low Level Laser System for Aesthetic Use.'' This guidance document describes a means by which low level laser systems for aesthetic use may comply with the requirement of special controls for class...

  2. Cone beam CT guidance provides superior accuracy for complex needle paths compared with CT guidance

    PubMed Central

    Braak, S J; Fütterer, J J; van Strijen, M J L; Hoogeveen, Y L; de Lange, F; Schultze Kool, L J

    2013-01-01

    Objective: To determine the accuracy of cone beam CT (CBCT) guidance and CT guidance in reaching small targets in relation to needle path complexity in a phantom. Methods: CBCT guidance combines three-dimensional CBCT imaging with fluoroscopy overlay and needle planning software to provide real-time needle guidance. The accuracy of needle positioning, quantified as deviation from a target, was assessed for inplane, angulated and double angulated needle paths. Four interventional radiologists reached four targets along the three paths using CBCT and CT guidance. Accuracies were compared between CBCT and CT for each needle path and between the three approaches within both modalities. The effect of user experience in CBCT guidance was also assessed. Results: Accuracies for CBCT were significantly better than CT for the double angulated needle path (2.2 vs 6.7 mm, p<0.001) for all radiologists. CBCT guidance showed no significant differences between the three approaches. For CT, deviations increased with increasing needle path complexity from 3.3 mm for the inplane placements to 4.4 mm (p=0.007) and 6.7 mm (p<0.001) for the angulated and double angulated CT-guided needle placements, respectively. For double angulated needle paths, experienced CBCT users showed consistently higher accuracies than trained users [1.8 mm (range 1.2–2.2) vs 3.3 mm (range 2.1–7.2) deviation from target, respectively; p=0.003]. Conclusion: In terms of accuracy, CBCT is the preferred modality, irrespective of the level of user experience, for more difficult guidance procedures requiring double angulated needle paths as in oncological interventions. Advances in knowledge: Accuracy of CBCT guidance has not been discussed before. CBCT guidance allows accurate needle placement irrespective of needle path complexity. For angulated and double-angulated needle paths, CBCT is more accurate than CT guidance. PMID:23913308

  3. Comprehensive Guidance Programs That Work.

    ERIC Educational Resources Information Center

    Gysbers, Norman C.; And Others

    This monograph describes how the comprehensive guidance model is transforming elementary-secondary school guidance and counseling programs in schools across the country. It incorporates the ideas and experiences of 12 guidance program developers in the actual use of the comprehensive guidance model in diverse school and cultural settings. The book…

  4. Vocational Guidance and the Labour Market: Guidance to Transform or Guidance to Domesticate?

    ERIC Educational Resources Information Center

    Kann, Ulla

    1988-01-01

    Explores the conflict in guidance arising from the desire to consider the needs of society while guaranteeing individual freedom of choice. Discusses the theoretical basis of vocational guidance. Gives examples of "domestication" and "transformation" approaches to guidance and discusses the consequences of viewing guidance as a change strategy.(KO)

  5. Sole Source Aquifer designation: petitioner guidance

    SciTech Connect

    Braem, L.

    1987-02-01

    The purpose of the guidance is to aid potential Sole Source Aquifer (SSA) petitioners to prepare and submit Sole Source Aquifer designation petitions to the Environmental Protection Agency. The Sole Source Aquifer program was established under the 1974 Safe Drinking Water Act, to protect principal or sole sources of drinking water for an area from contamination. The guidance presents an overview of the designation process, petition preparation, and how and where to submit petition information. Also included is general information about the Sole Source Aquifer program.

  6. Architects of Their Own Future? Swedish Career Guidance Policies

    ERIC Educational Resources Information Center

    Lundahl, Lisbeth; Nilsson, Goran

    2009-01-01

    Few studies have researched career guidance and information policies, particularly at the regional and local level. This article analyses Sweden's national governance of career guidance in schools from 1950 to 2007, and governance at the local level in today's highly decentralised Swedish educational system. The analysis is based on national…

  7. Understanding the EPA guidance on major source determinations for military installations

    SciTech Connect

    Ling, A.D.

    1997-12-31

    In August 1996, the Environmental Protection Agency (EPA) issued the first ever Clean Air Act (CAA) guidance directed specifically at military facilities. The Guidance, titled Major Source Determinations for Military Installations under the Air Toxics, New Source Review and Title V Operating Permit Programs of the Clean Air Act, was negotiated by an EPA/DoD workgroup that included field and headquarters EPA and DoD representatives, and was led by the Navy. This paper describes the development and contents of the guidance and the significant legal and policy issues raised. By statute and rule, all sources under common control on contiguous or adjacent property and belonging to the same two digit Standard Industrial Classification (SIC) Code must be aggregated when determining if the source is a major source. DoD requested that EPA develop the guidance because of a move by EPA to impose a fenceline-to-fenceline interpretation of what constitutes a major source for purposes of the three programs identified above. Such an interpretation could and did result in more stringent regulation of industrial sources on military installations than of similar industrial plants. The guidance establishes EPA`s allowable interpretation of two of the three key elements of the major source definition. First, the guidance specifies that common control occurs at the military service level; therefore, sources belonging to the Army, Navy, Marine Corps, Air Force, the National Guard or a Defense Agency that are located on the same installation could each be treated separately. Second, the guidance allows the military to assign SIC codes to functional industrial groupings in a manner similar to the private sector. Past practice grouped all national defense activities under the same SIC code.

  8. Quality in Careers Guidance.

    ERIC Educational Resources Information Center

    Plant, Peter

    This paper examines quality issues in career guidance, counseling, and information services in Europe and elsewhere from a range of different perspectives related to economic, ethical, and/or effectiveness criteria. Selected examples from the European Union member states, Canada, and the United States are used to illustrate how quality is…

  9. Vocational Development and Guidance.

    ERIC Educational Resources Information Center

    Tennyson, W. Wesley; And Others

    The vocational education volume considers questions of career development, the role of guidance in the school, vocational training, the relation of self-concept to vocational choice, and occupational information. Twenty-six papers deal with theories of vocational behavior, the success of vocational education programs, and testing information.…

  10. Application of State and Federal Guidelines for Establishing Alternate Soil Clean-Up Levels for the Protection of Groundwater at the Hanford Site

    SciTech Connect

    Leary, K.; McMahon, W.; Hoover, J.

    2008-07-01

    Risk-based soil cleanup levels that are protective of groundwater have been calculated for use in environmental remediation activities at the Hanford Site using vadose zone fate and transport modeling. The determination of soil cleanup levels is important because it involves the technical basis for the levels of contamination that can be left in place, which are protective of human health and the environment. The determination of risk-based soil cleanup levels is an especially important issue at the Hanford Site where site conditions such as a semi-arid climate, and a thick vadose zone of over 100 meters necessitate the use of appropriate risk-based methods. In the absence of an alternative risk-based approach, the cleanup levels default to background, detection limits, or simplistic formulas not intended for applications involving these distinctive site conditions. However, the use of vadose zone fate and transport modeling for risk-based applications such as the determination of soil cleanup levels in the vadose zone are not as well established as modeling for groundwater applications. Thus, the use of models in this manner involves additional challenges for the demonstration of the efficacy of its use for risk-based applications, in accordance with federal and state regulatory requirements and guidelines. An approach has been developed to integrate with federal and state regulatory guidelines in conjunction with the development of the risk-based methodology. Demonstration of integration with these guidelines primarily involves documentation of the objectives of the problem to be solved, the technical basis and rationale associated with the selection of an appropriate risk-based method (e.g., model type and code selection), and documentation associated with the use of the model, e.g., conceptual site model, parameter estimation, uncertainty and assumptions analyses, and model results. (authors)

  11. 75 FR 7315 - Guidance for Reporting and Use of Information Concerning Recipient Integrity and Performance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-18

    ... Acquisition Regulation (74 FR 45579, September 3, 2009). The proposed new 2 CFR guidance does not address data... guidance to agencies to establish: (a) The Dun and Bradstreet (D&B) Data Universal Numbering System (DUNS... Management and Budget 2 CFR Subtitle A, Chapter I, Parts 25, 27, 35, et al. Guidance for Reporting and Use...

  12. False Dawns, Bleak Sunset: The Coalition Government's Policies on Career Guidance

    ERIC Educational Resources Information Center

    Watts, A. G.

    2013-01-01

    The Coalition Government's policies on career guidance are analysed. Its rhetorical concern for career guidance provision is based largely on its support for social mobility, and its recognition of the role of career guidance in moving towards a demand-led skills system. Initial policy statements affirmed its intention to establish an all-age…

  13. 77 FR 59928 - Draft Guidance for Industry on Complicated Intra-Abdominal Infections: Developing Drugs for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... clinical trial designs to support approval of drugs. DATES: Although you can comment on any guidance at any... previously conducted clinical trials with various effective antibiotics. The draft guidance also provides a... of information referred to in the guidance for clinical trial sponsors ``Establishment and...

  14. Sensitivity of a helical diode array device to delivery errors in IMRT treatment and establishment of tolerance level for pretreatment QA.

    PubMed

    García-Vicente, Feliciano; Fernández, Virginia; Bermúdez, Rocío; Gómez, Alberto; Pérez, Leopoldo; Zapatero, Almudena; Torres, Juan J

    2012-01-05

    The aim of this study is to determine the gantry angle and multileaf collimator (MLC) gap error-detection threshold of a diode helical array with an inserted micro-ionization chamber in order to use this device for the pretreatment quality assurance (QA) of intensity-modulated radiation therapy (IMRT) treatments. Implications on the dose-volume histograms (DVHs) of the patient treatments will also be considered for the establishment of a QA protocol with a reasonable tolerance level. Three dynamic IMRT HN (head and neck) and prostate treatments were studied. Random and systematic variations of gantry angle and systematic errors in MLC gap width of the clinical treatments were analyzed in order to establish the detection sensitivity of the array. The associated clinical significance was studied introducing the same errors in the treatment plan based on the patients' computed tomography (CT) and calculating the corresponding DVHs. The Gamma (3%/3 mm) presented a 4% variation in failure rate for a rotation error of 1° for both types of treatment. Both systematic and random errors in gantry rotation angle have little effect on the patients' DVHs. MLC gap width errors of 1 mm and 2 mm in the prostate treatments imply a mean variation in isocenter-measured absorbed dose of 2.1% and 4.1%, respectively. In the case of HN, these errors entail a change in measured isocenter dose of 4.7% and 8.6%, respectively. The variation observed in the DVHs of the patients was, basically, a global displacement of the curves proportional to the isocenter dose variation caused by the gap width error. According to the array sensitivity to the analyzed errors and its implication in patient DVHs, a tolerance of 95% point passing rate for the gamma criterion 3%/2 mm and an agreement of 2% in isocenter absolute dose have been established as tolerance criteria for our pretreatment IMRT QA protocol.

  15. Radiation dose in coronary angiography and intervention: initial results from the establishment of a multi-centre diagnostic reference level in Queensland public hospitals

    SciTech Connect

    Crowhurst, James A; Whitby, Mark; Thiele, David; Halligan, Toni; Westerink, Adam; Crown, Suzanne; Milne, Jillian

    2014-09-15

    Radiation dose to patients undergoing invasive coronary angiography (ICA) is relatively high. Guidelines suggest that a local benchmark or diagnostic reference level (DRL) be established for these procedures. This study sought to create a DRL for ICA procedures in Queensland public hospitals. Data were collected for all Cardiac Catheter Laboratories in Queensland public hospitals. Data were collected for diagnostic coronary angiography (CA) and single-vessel percutaneous intervention (PCI) procedures. Dose area product (P{sub KA}), skin surface entrance dose (K{sub AR}), fluoroscopy time (FT), and patient height and weight were collected for 3 months. The DRL was set from the 75th percentile of the P{sub KA.} 2590 patients were included in the CA group where the median FT was 3.5 min (inter-quartile range = 2.3–6.1). Median K{sub AR} = 581 mGy (374–876). Median P{sub KA} = 3908 uGym{sup 2} (2489–5865) DRL = 5865 uGym{sup 2}. 947 patients were included in the PCI group where median FT was 11.2 min (7.7–17.4). Median K{sub AR} = 1501 mGy (928–2224). Median P{sub KA} = 8736 uGym{sup 2} (5449–12,900) DRL = 12,900 uGym{sup 2}. This study established a benchmark for radiation dose for diagnostic and interventional coronary angiography in Queensland public facilities.

  16. Enhancing Access to Vocational Guidance.

    ERIC Educational Resources Information Center

    Clayton, Pam

    1998-01-01

    Issues in vocational guidance for adults include lack of provision, especially for unemployed or disadvantaged people and the need to publicize existing excellent guidance services and demonstrate their usefulness to this population. (SK)

  17. 78 FR 54899 - Draft Guidance for Industry on Specification of the Unique Facility Identifier System for Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-06

    ...) System for Drug Establishment Registration.'' This draft guidance specifies the UFI system for... guidance specifies the UFI system as follows. At this time, FDA's preferred UFI for a drug establishment is... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Specification of the...

  18. Vocational Guidance and Human Development.

    ERIC Educational Resources Information Center

    Herr, Edwin L., Ed.

    New knowledge and practices in the area of vocational guidance and human growth and development that have occurred since 1964 as well as future directions for guidance, both nationally and internationally, are covered in this second volume of a decennial volume series sponsored by the National Vocational Guidance Association to up-date the…

  19. Establishing desirable fortificant levels for calcium, iron and zinc in foods for infant and young child feeding: examples from three Asian countries.

    PubMed

    Gibbs, Michelle M; Carriquiry, Alicia L; Capanzana, Mario V; Gibson, Rosalind S

    2014-01-01

    We used the World Health Organization's recommended procedures to establish desirable fortificant levels for three problem micronutrients in children's diets, based on dietary data collected earlier from Filipino (n = 1374; 6-36 months), Mongolian (n = 179; 12-36 months) and Cambodian (n = 177; 12-36 months) children. Prevalence of inadequate and excessive intakes of calcium and zinc (via cut-point method) and iron (via full-probability approach) was assessed after adjusting usual intake distributions with pc-side using internal or external within-person variances from Filipino (calcium and iron) and US National Health And Nutrition Examination Survey III (zinc) national surveys. Fortificant levels were determined by repositioning usual intake distributions so that the 2.5th percentile of the targeted populations equalled the estimated average requirement (calcium, zinc) or so that full-probability prevalence was no larger than 2.5% (iron). Prevalence of inadequate intakes was ≥70% for calcium and iron, except Filipino infants (30% for Ca) and Cambodian toddlers (41% for Fe); but <1% for zinc for toddlers in Mongolia and 20% in Cambodia. Prevalence of excessive intakes was <1% for zinc, calcium and iron, except for Mongolian toddlers (11% for Zn). Desirable fortificant levels, although apparently negligible for zinc, were 530-783 mg for calcium and 10.8-22.8 mg for iron (per 100 g). Fortificant levels can be estimated from 24-h recalls, preferably by applying internal within-person variances. Fortification with calcium and iron was necessary, but seemingly not for zinc, despite a high prevalence of low serum zinc, suggesting the need for better defined cut-offs for population risk of zinc deficiency based on dietary zinc intake and/or serum zinc. PMID:22515230

  20. Trajectory shaping rendezvous guidance

    NASA Astrophysics Data System (ADS)

    Klumpp, A. R.

    The Space Station will bring a great increase in rendezvous traffic. Formerly, rendezvous has been expensive in terms of time and crew involvement. Multiple trajectory adjustments on separate orbits have been required to meet safety, lighting, and geometry requirements. This paper describes a new guidance technique in which the approach trajectory is shaped by a sequence of velocity increments in order to satisfy multiple constraints within a single orbit. The approach phase is planned before the mission, leaving a group of free parameters that are optimized by onboard guidance. Fuel penalties are typically a few percent, compared to unshaped Hohmann transfers, and total fuel costs can be less than those of more time-consuming ways of meeting the same requirements.

  1. Environmental guidance regulatory bulletin

    SciTech Connect

    1997-01-31

    This document describes the background on expanding public participation in the Resource Conservation and Recovery Act and DOE`s response. The bulletin also describes the changes made by the final rule to existing regulations, guidance provided by EPA in the preamble and in the revised RCRA Public Participation Manual, the relationship between public participation and environmental justice, and DOE`s recent public participation and environmental justice initiatives.

  2. A study for proposal of use of regulatory T cells as a prognostic marker and establishing an optimal threshold level for their expression in chronic lymphocytic leukemia.

    PubMed

    Dasgupta, Alakananda; Mahapatra, Manoranjan; Saxena, Renu

    2015-06-01

    Although regulatory T cells (Tregs) have been extensively studied in chronic lymphocytic leukemia, there is no uniform guideline or consensus regarding their use as a prognostic marker. This study describes the methodology used to develop an optimal threshold level for Tregs in these patients. Treg levels were assessed in the peripheral blood of 130 patients and 150 controls. Treg frequencies were linked to established prognostic markers as well as overall survival and time to first treatment. The cut-offs for Treg positivity were assessed by receiver operating characteristic (ROC) analysis. A cut-off of 5.7% for Treg cell percentage and of 35 cells/μL for absolute Treg cell count were determined as optimal in patients with CLL along with a median Treg percentage of 15.5% used to separate patients with low- and high-risk disease. The experiments presented here will possibly aid in the use of Treg frequencies as a potential prognostic marker in CLL.

  3. Nuc-ErbB3 regulates H3K27me3 levels and HMT activity to establish epigenetic repression during peripheral myelination.

    PubMed

    Ness, Jennifer K; Skiles, Amanda A; Yap, Eng-Hui; Fajardo, Eduardo J; Fiser, Andras; Tapinos, Nikos

    2016-06-01

    Nuc-ErbB3 an alternative transcript from the ErbB3 locus binds to a specific DNA motif and associates with Schwann cell chromatin. Here we generated a nuc-ErbB3 knockin mouse that lacks nuc-ErbB3 expression in the nucleus without affecting the neuregulin-ErbB3 receptor signaling. Nuc-ErbB3 knockin mice exhibit hypermyelination and aberrant myelination at the paranodal region. This phenotype is attributed to de-repression of myelination associated gene transcription following loss of nuc-ErbB3 and histone H3K27me3 promoter occupancy. Nuc-ErbB3 knockin mice exhibit reduced association of H3K27me3 with myelination-associated gene promoters and increased RNA Pol-II rate of transcription of these genes. In addition, nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells. Nuc-ErbB3 knockin mice exhibit significant decrease of histone H3K27me3 methyltransferase (HMT) activity and reduced levels of H3K27me3. Collectively, nuc-ErbB3 is a master transcriptional repressor, which regulates HMT activity to establish a repressive chromatin landscape on promoters of genes during peripheral myelination.

  4. Nuc‐ErbB3 regulates H3K27me3 levels and HMT activity to establish epigenetic repression during peripheral myelination

    PubMed Central

    Ness, Jennifer K.; Skiles, Amanda A.; Yap, Eng‐Hui; Fajardo, Eduardo J.; Fiser, Andras

    2016-01-01

    Nuc‐ErbB3 an alternative transcript from the ErbB3 locus binds to a specific DNA motif and associates with Schwann cell chromatin. Here we generated a nuc‐ErbB3 knockin mouse that lacks nuc‐ErbB3 expression in the nucleus without affecting the neuregulin‐ErbB3 receptor signaling. Nuc‐ErbB3 knockin mice exhibit hypermyelination and aberrant myelination at the paranodal region. This phenotype is attributed to de‐repression of myelination associated gene transcription following loss of nuc‐ErbB3 and histone H3K27me3 promoter occupancy. Nuc‐ErbB3 knockin mice exhibit reduced association of H3K27me3 with myelination‐associated gene promoters and increased RNA Pol‐II rate of transcription of these genes. In addition, nuc‐ErbB3 directly regulates levels of H3K27me3 in Schwann cells. Nuc‐ErbB3 knockin mice exhibit significant decrease of histone H3K27me3 methyltransferase (HMT) activity and reduced levels of H3K27me3. Collectively, nuc‐ErbB3 is a master transcriptional repressor, which regulates HMT activity to establish a repressive chromatin landscape on promoters of genes during peripheral myelination. GLIA 2016;64:977–992 PMID:27017927

  5. Human-system Interfaces to Automatic Systems: Review Guidance and Technical Basis

    SciTech Connect

    OHara, J.M.; Higgins, J.C.

    2010-01-31

    Automation has become ubiquitous in modern complex systems and commercial nuclear power plants are no exception. Beyond the control of plant functions and systems, automation is applied to a wide range of additional functions including monitoring and detection, situation assessment, response planning, response implementation, and interface management. Automation has become a 'team player' supporting plant personnel in nearly all aspects of plant operation. In light of the increasing use and importance of automation in new and future plants, guidance is needed to enable the NRC staff to conduct safety reviews of the human factors engineering (HFE) aspects of modern automation. The objective of the research described in this report was to develop guidance for reviewing the operator's interface with automation. We first developed a characterization of the important HFE aspects of automation based on how it is implemented in current systems. The characterization included five dimensions: Level of automation, function of automation, modes of automation, flexibility of allocation, and reliability of automation. Next, we reviewed literature pertaining to the effects of these aspects of automation on human performance and the design of human-system interfaces (HSIs) for automation. Then, we used the technical basis established by the literature to develop design review guidance. The guidance is divided into the following seven topics: Automation displays, interaction and control, automation modes, automation levels, adaptive automation, error tolerance and failure management, and HSI integration. In addition, we identified insights into the automaton design process, operator training, and operations.

  6. Educational and Vocational Guidance in Denmark. Education in Denmark.

    ERIC Educational Resources Information Center

    Ministry of Education, Copenhagen (Denmark).

    This report sketches educational and vocational guidance in Denmark. It begins with a historical account of developments in the areas of career and school counseling. Outlined next are guidance programs at the following levels: folkeskole, gymnasium and studenterkursus (upper secondary education), higher preparatory examination, vocational school,…

  7. The Comprehensive Career Education System: Elementary Guidance K-6.

    ERIC Educational Resources Information Center

    Educational Properties Inc., Irvine, CA.

    Elementary guidance materials providing career education activities for grades K-6 are presented for utilization by elementary teachers and elementary guidance specialists. Arranged by grade level, materials cover the following career education concepts: appreciation and attitudes, self-awareness, decision making, career awareness, and educational…

  8. Guidance Exploration Model (GEM) 1978-79. Summary.

    ERIC Educational Resources Information Center

    Pope, M. Candice, Comp.

    The original program goal for development was to provide implementation of a Guidance Exploratory Model (GEM) at the elementary level which combines career education, guidance, exploration and academics. During the planning stages of GEM, monies were received from Title IV-B to purchase books and audio-visual materials to initiate the concept…

  9. Finding the Optimal Guidance for Enhancing Anchored Instruction

    ERIC Educational Resources Information Center

    Zydney, Janet Mannheimer; Bathke, Arne; Hasselbring, Ted S.

    2014-01-01

    This study investigated the effect of different methods of guidance with anchored instruction on students' mathematical problem-solving performance. The purpose of this research was to iteratively design a learning environment to find the optimal level of guidance. Two iterations of the software were compared. The first iteration used…

  10. Guidance for Human-system Interfaces to Automatic Systems

    SciTech Connect

    O'Hara, J.M.; Higgins, J.; Stephen Fleger; Valerie Barnes

    2010-09-27

    Automation is ubiquitous in modern complex systems, and commercial nuclear- power plants are no exception. Automation is applied to a wide range of functions, including monitoring and detection, situation assessment, response planning, and response implementation. Automation has become a 'team player' supporting personnel in nearly all aspects of system operation. In light of its increasing use and importance in new- and future-plants, guidance is needed to conduct safety reviews of the operator's interface with automation. The objective of this research was to develop such guidance. We first characterized the important HFE aspects of automation, including six dimensions: Levels, functions, processes, modes, flexibility, and reliability. Next, we reviewed literature on the effects of all of these aspects of automation on human performance, and on the design of human-system interfaces (HSIs). Then, we used this technical basis established from the literature to identify general principles for human-automation interaction and to develop review guidelines. The guidelines consist of the following seven topics: Automation displays, interaction and control, automation modes, automation levels, adaptive automation, error tolerance and failure management, and HSI integration.

  11. SU-E-P-08: Establishment of Local Diagnostic Reference Levels of Routine Abdomen Exam in Computed Tomography According to Body Weight

    SciTech Connect

    Wang, H; Wang, Y; Weng, H

    2015-06-15

    Purpose: The national diagnostic reference levels (NDRLs) is an efficient, concise and powerful standard for optimizing radiation protection of a patient. However, for each hospital the dose-reducing potential of focusing on establishment of local DRLs (LDRLs). A lot of study reported that Computed tomography exam contributed majority radiation dose in different medical modalities, therefore, routine abdomen CT exam was choose in initial pilot study in our study. Besides the mAs of routine abdomen CT exam was decided automatic exposure control by linear attenuation is relate to body shape of patient. In this study we would like to establish the local diagnostic reference levels of routine abdomen exam in computed tomography according to body weight of patient. Methods and Materials: There are two clinical CT scanners (a Toshiba Aquilion and a Siemens Sensation) were performed in this study. For CT examinations the basic recommended dosimetric quantity is the Computed Tomography Dose Index (CTDI). The patient sample involved 82 adult patients of both sexes and divided into three groups by their body weight (50–60 kg, 60–70 kg, 70–80 kg).Carried out the routine abdomen examinations, and all exposure parameters have been collected and the corresponding CTDIv and DLP values have been determined. The average values were compared with the European DRLs. Results: The majority of patients (75%) were between 50–70 Kg of body weight, the numbers of patient in each group of weight were 40–50:7; 50–60:29; 60–70:33; 70–80:13. The LDRLs in each group were 10.81mGy, 14.46mGy, 20.27mGy and 21.04mGy, respectively. The DLP were 477mGy, 630mGy, 887mGy and 959mGy, respectively. No matter which group the LDRLs were lower than European DRLs. Conclusions: We would like to state that this was a pioneer work in local hospital in Chiayi. We hope that this may lead the way to further developments in Taiwan.

  12. Challenges in establishing LLW disposal capacity: Pennsylvania`s perspective

    SciTech Connect

    Dornsife, W.P.; Saraka, L.J.

    1989-11-01

    Even though Pennsylvania is host state for the Compact, state implementing legislation was non-existent until early 1988. In February of 1998 Governor Casey signed the Los-Level Radioactive Waste Disposal Act (Act) into law. The Act incorporates three years of Departmental work and interaction with the legislature, a Public Advisory Committee on Low-Level Waste, many interest groups and the general public. It is a comprehensive Act that: provides the Department with broad powers and duties to manage, license and regulate a low-level waste disposal program; requires development phase; and establishes benefits and guarantees for communities affected by the establishment and operation of a low-level waste site. The Department considers that its powers and duties to manage, license and regulate a low-level waste disposal program begins with interpreting the provisions established by the Act. Interpretation will establish how the Department intends to implement its authority. The Department is communicating interpretations through various methods such as regulation, policy, and written or verbal guidance. Interpretations typically require a mix of technical, policy, and social solutions to clarify concepts established by law. This paper identifies select items established by law that require technical solutions. Its purpose is to share some creative approaches for solving unmanageable legislature requirements.

  13. A review of background dioxin concentrations in urban/suburban and rural soils across the United States: implications for site assessments and the establishment of soil cleanup levels.

    PubMed

    Urban, Jonathan D; Wikoff, Daniele S; Bunch, Alea T G; Harris, Mark A; Haws, Laurie C

    2014-01-01

    establishing soil screening levels and PRGs that are lower than background concentrations.

  14. Establishing an Appropriate Level of Detail (LoD) for a Building Information Model (BIM) - West Block, Parliament Hill, Ottawa, Canada

    NASA Astrophysics Data System (ADS)

    Fai, S.; Rafeiro, J.

    2014-05-01

    In 2011, Public Works and Government Services Canada (PWGSC) embarked on a comprehensive rehabilitation of the historically significant West Block of Canada's Parliament Hill. With over 17 thousand square meters of floor space, the West Block is one of the largest projects of its kind in the world. As part of the rehabilitation, PWGSC is working with the Carleton Immersive Media Studio (CIMS) to develop a building information model (BIM) that can serve as maintenance and life-cycle management tool once construction is completed. The scale and complexity of the model have presented many challenges. One of these challenges is determining appropriate levels of detail (LoD). While still a matter of debate in the development of international BIM standards, LoD is further complicated in the context of heritage buildings because we must reconcile the LoD of the BIM with that used in the documentation process (terrestrial laser scan and photogrammetric survey data). In this paper, we will discuss our work to date on establishing appropriate LoD within the West Block BIM that will best serve the end use. To facilitate this, we have developed a single parametric model for gothic pointed arches that can be used for over seventy-five unique window types present in the West Block. Using the AEC (CAN) BIM as a reference, we have developed a workflow to test each of these window types at three distinct levels of detail. We have found that the parametric Gothic arch significantly reduces the amount of time necessary to develop scenarios to test appropriate LoD.

  15. Asymmetric Dimethylarginine Is a Well Established Mediating Risk Factor for Cardiovascular Morbidity and Mortality-Should Patients with Elevated Levels Be Supplemented with Citrulline?

    PubMed

    McCarty, Mark F

    2016-01-01

    The arginine metabolite asymmetric dimethylarginine (ADMA) is a competitive inhibitor and uncoupler of endothelial nitric oxide synthase (eNOS), an enzyme that acts in multifarious ways to promote cardiovascular health. This phenomenon likely explains, at least in part, why elevated ADMA has been established as an independent risk factor for cardiovascular events, ventricular hypertrophy, and cardiovascular mortality. Fortunately, the suppressive impact of ADMA on eNOS activity can be offset by increasing intracellular arginine levels with supplemental citrulline. Although the long-term impact of supplemental citrulline on cardiovascular health in patients with elevated ADMA has not yet been studied, shorter-term clinical studies of citrulline administration demonstrate effects suggestive of increased NO synthesis, such as reductions in blood pressure and arterial stiffness, improved endothelium-dependent vasodilation, increased erection hardness, and increased ejection fractions in patients with heart failure. Supplemental citrulline could be a practical option for primary or secondary prevention of cardiovascular events and mortality, as it is inexpensive, has a mild flavor, and is well tolerated in doses (3-6 g daily) that can influence eNOS activity. Large and long-term clinical trials, targeting patients at high risk for cardiovascular events in whom ADMA is elevated, are needed to evaluate citrulline's potential for aiding cardiovascular health. PMID:27417628

  16. Application of an in vitro DDASS to evaluate oral absorption of two chemicals simultaneously: establishment of a level A in vitro-in vivo correlation.

    PubMed

    Hou, Jipeng; He, Xin; Xu, Xuefang; Shi, Xiaoyan; Xu, Yanyan; Liu, Changxiao

    2012-11-01

    The aim of this study was to evaluate the oral absorption of two chemicals simultaneously using a drug dissolution/absorption simulating system (DDASS), and to establish a correlation between DDASS and in vivo absorption to clarify the prediction of this in vitro model. Ferulic acid (FA) and tetrahydropalmatine (THP), the components of Angelicae Sinensis Radix and Corydalis Yanhusuo Rhizoma, respectively, were chosen as model compounds. Three groups including FA, THP, and FA and THP together (FA + THP) were studied in DDASS. The corresponding in vivo pharmacokinetics study was performed in rats. Then the correlation was analysed between DDASS permeation in vitro and rat absorption data in vivo. A strong level A correlation (r > 0.84) was obtained after a correlation coefficient test (p < 0.05 or 0.01). Moreover, when FA and THP were used together in DDASS, the cumulative permeation of FA increased by 38.5%, while THP permeation decreased by 25.8%. In rats, the area under the concentration-time curve from time to infinity for FA increased 2.6-fold, while THP decreased 19.6%. The changes in rat intestinal permeation modeled by the DDASS were consistent with the absorption changes in rats. We conclude that DDASS is a valid in vitro model to evaluate oral absorption of two drug components simultaneously and reflect the in vivo characteristics of drug absorption accurately.

  17. Establishment of Biosafety Level-3 (BSL-3) laboratory: important criteria to consider while designing, constructing, commissioning & operating the facility in Indian setting.

    PubMed

    Mourya, Devendra T; Yadav, Pragya D; Majumdar, Triparna Dutta; Chauhan, Devendra S; Katoch, Vishwa Mohan

    2014-08-01

    Since the enactment of Environmental Protection Act in 1989 and Department of Biotechnology (DBT) guidelines to deal with genetically modified organisms, India has embarked on establishing various levels of biosafety laboratories to deal with highly infectious and pathogenic organisms. Occurrence of outbreaks due to rapidly spreading respiratory and haemorrhagic fever causing viruses has caused an urgency to create a safe laboratory environment. This has thus become a mandate, not only to protect laboratory workers, but also to protect the environment and community. In India, technology and science are progressing rapidly. Several BSL-3 [=high containment] laboratories are in the planning or execution phase, to tackle biosafety issues involved in handling highly infectious disease agents required for basic research and diagnosis. In most of the developing countries, the awareness about biocontainment has increased but planning, designing, constructing and operating BSL-3 laboratories need regular updates about the design and construction of facilities and clear definition of risk groups and their handling which should be in harmony with the latest international practices. This article describes the major steps involved in the process of construction of a BSL-3 laboratory in Indian settings, from freezing the concept of proposal to operationalization phase. The key to success of this kind of project is strong institutional commitment to biosafety norms, adequate fund availability, careful planning and designing, hiring good construction agency, monitoring by experienced consultancy agency and involvement of scientific and engineering personnel with biocontainment experience in the process.

  18. Asymmetric Dimethylarginine Is a Well Established Mediating Risk Factor for Cardiovascular Morbidity and Mortality-Should Patients with Elevated Levels Be Supplemented with Citrulline?

    PubMed

    McCarty, Mark F

    2016-07-08

    The arginine metabolite asymmetric dimethylarginine (ADMA) is a competitive inhibitor and uncoupler of endothelial nitric oxide synthase (eNOS), an enzyme that acts in multifarious ways to promote cardiovascular health. This phenomenon likely explains, at least in part, why elevated ADMA has been established as an independent risk factor for cardiovascular events, ventricular hypertrophy, and cardiovascular mortality. Fortunately, the suppressive impact of ADMA on eNOS activity can be offset by increasing intracellular arginine levels with supplemental citrulline. Although the long-term impact of supplemental citrulline on cardiovascular health in patients with elevated ADMA has not yet been studied, shorter-term clinical studies of citrulline administration demonstrate effects suggestive of increased NO synthesis, such as reductions in blood pressure and arterial stiffness, improved endothelium-dependent vasodilation, increased erection hardness, and increased ejection fractions in patients with heart failure. Supplemental citrulline could be a practical option for primary or secondary prevention of cardiovascular events and mortality, as it is inexpensive, has a mild flavor, and is well tolerated in doses (3-6 g daily) that can influence eNOS activity. Large and long-term clinical trials, targeting patients at high risk for cardiovascular events in whom ADMA is elevated, are needed to evaluate citrulline's potential for aiding cardiovascular health.

  19. Asymmetric Dimethylarginine Is a Well Established Mediating Risk Factor for Cardiovascular Morbidity and Mortality—Should Patients with Elevated Levels Be Supplemented with Citrulline?

    PubMed Central

    McCarty, Mark F.

    2016-01-01

    The arginine metabolite asymmetric dimethylarginine (ADMA) is a competitive inhibitor and uncoupler of endothelial nitric oxide synthase (eNOS), an enzyme that acts in multifarious ways to promote cardiovascular health. This phenomenon likely explains, at least in part, why elevated ADMA has been established as an independent risk factor for cardiovascular events, ventricular hypertrophy, and cardiovascular mortality. Fortunately, the suppressive impact of ADMA on eNOS activity can be offset by increasing intracellular arginine levels with supplemental citrulline. Although the long-term impact of supplemental citrulline on cardiovascular health in patients with elevated ADMA has not yet been studied, shorter-term clinical studies of citrulline administration demonstrate effects suggestive of increased NO synthesis, such as reductions in blood pressure and arterial stiffness, improved endothelium-dependent vasodilation, increased erection hardness, and increased ejection fractions in patients with heart failure. Supplemental citrulline could be a practical option for primary or secondary prevention of cardiovascular events and mortality, as it is inexpensive, has a mild flavor, and is well tolerated in doses (3–6 g daily) that can influence eNOS activity. Large and long-term clinical trials, targeting patients at high risk for cardiovascular events in whom ADMA is elevated, are needed to evaluate citrulline’s potential for aiding cardiovascular health. PMID:27417628

  20. Establishment of Biosafety Level-3 (BSL-3) laboratory: Important criteria to consider while designing, constructing, commissioning & operating the facility in Indian setting

    PubMed Central

    Mourya, Devendra T.; Yadav, Pragya D.; Majumdar, Triparna Dutta; Chauhan, Devendra S.; Katoch, Vishwa Mohan

    2014-01-01

    Since the enactment of Environmental Protection Act in 1989 and Department of Biotechnology (DBT) guidelines to deal with genetically modified organisms, India has embarked on establishing various levels of biosafety laboratories to deal with highly infectious and pathogenic organisms. Occurrence of outbreaks due to rapidly spreading respiratory and haemorrhagic fever causing viruses has caused an urgency to create a safe laboratory environment. This has thus become a mandate, not only to protect laboratory workers, but also to protect the environment and community. In India, technology and science are progressing rapidly. Several BSL-3 [=high containment] laboratories are in the planning or execution phase, to tackle biosafety issues involved in handling highly infectious disease agents required for basic research and diagnosis. In most of the developing countries, the awareness about biocontainment has increased but planning, designing, constructing and operating BSL-3 laboratories need regular updates about the design and construction of facilities and clear definition of risk groups and their handling which should be in harmony with the latest international practices. This article describes the major steps involved in the process of construction of a BSL-3 laboratory in Indian settings, from freezing the concept of proposal to operationalization phase. The key to success of this kind of project is strong institutional commitment to biosafety norms, adequate fund availability, careful planning and designing, hiring good construction agency, monitoring by experienced consultancy agency and involvement of scientific and engineering personnel with biocontainment experience in the process. PMID:25297350

  1. Establishment of Biosafety Level-3 (BSL-3) laboratory: important criteria to consider while designing, constructing, commissioning & operating the facility in Indian setting.

    PubMed

    Mourya, Devendra T; Yadav, Pragya D; Majumdar, Triparna Dutta; Chauhan, Devendra S; Katoch, Vishwa Mohan

    2014-08-01

    Since the enactment of Environmental Protection Act in 1989 and Department of Biotechnology (DBT) guidelines to deal with genetically modified organisms, India has embarked on establishing various levels of biosafety laboratories to deal with highly infectious and pathogenic organisms. Occurrence of outbreaks due to rapidly spreading respiratory and haemorrhagic fever causing viruses has caused an urgency to create a safe laboratory environment. This has thus become a mandate, not only to protect laboratory workers, but also to protect the environment and community. In India, technology and science are progressing rapidly. Several BSL-3 [=high containment] laboratories are in the planning or execution phase, to tackle biosafety issues involved in handling highly infectious disease agents required for basic research and diagnosis. In most of the developing countries, the awareness about biocontainment has increased but planning, designing, constructing and operating BSL-3 laboratories need regular updates about the design and construction of facilities and clear definition of risk groups and their handling which should be in harmony with the latest international practices. This article describes the major steps involved in the process of construction of a BSL-3 laboratory in Indian settings, from freezing the concept of proposal to operationalization phase. The key to success of this kind of project is strong institutional commitment to biosafety norms, adequate fund availability, careful planning and designing, hiring good construction agency, monitoring by experienced consultancy agency and involvement of scientific and engineering personnel with biocontainment experience in the process. PMID:25297350

  2. Forensic facial approximation assessment: can application of different average facial tissue depth data facilitate recognition and establish acceptable level of resemblance?

    PubMed

    Herrera, Lara Maria; Strapasson, Raíssa Ananda Paim; da Silva, Jorge Vicente Lopes; Melani, Rodolfo Francisco Haltenhoff

    2016-09-01

    Facial soft tissue thicknesses (FSTT) are important guidelines for modeling faces from skull. Amid so many FSTT data, Forensic artists have to make a subjective choice of a dataset that best meets their needs. This study investigated the performance of four FSTT datasets in the recognition and resemblance of Brazilian living individuals and the performance of assessors in recognizing people, according to sex and knowledge on Human Anatomy and Forensic Dentistry. Sixteen manual facial approximations (FAs) were constructed using three-dimensional (3D) prototypes of skulls (targets). The American method was chosen for the construction of the faces. One hundred and twenty participants evaluated all FAs by means of recognition and resemblance tests. This study showed higher proportions of recognition by FAs conducted with FSTT data from cadavers compared with those conducted with medical imaging data. Targets were also considered more similar to FAs conducted with FSTT data from cadavers. Nose and face shape, respectively, were considered the most similar regions to targets. The sex of assessors (male and female) and the knowledge on Human Anatomy and Forensic Dentistry did not play a determinant role to reach greater recognition rates. It was possible to conclude that FSTT data obtained from imaging may not facilitate recognition and establish acceptable level of resemblance. Grouping FSTT data by regions of the face, as proposed in this paper, may contribute to more accurate FAs.

  3. Endangerment assessment guidance. Final report

    SciTech Connect

    Not Available

    1985-10-21

    The directive clarifies the requirement that an endangerment assessment be developed to support all administrative and judicial enforcement actions under Section 106 of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and Section 7003 of the Resource Conservation and Recovery Act (RCRA). Before taking enforcement action under these provisions to abate the hazards or potential hazards at a site, the Environmental Protection Agency (EPA) must be able to properly document and justify its assertion that an imminent and substantial endangerment to public health or welfare or the environment may exist. The endangerment assessment provides the documentation and justification. The endangerment assessment is not necessary to support Section 104 actions. It also provides guidance on the content, timing, level of detail, format, and resources required for the preparation of endangerment assessments.

  4. Establishing operations

    PubMed Central

    Michael, Jack

    1993-01-01

    The first two books on behavior analysis (Skinner, 1938; Keller & Schoenfeld, 1950) had chapter-length coverage of motivation. The next generation of texts also had chapters on the topic, but by the late 1960s it was no longer being given much treatment in the behavior-analytic literature. The present failure to deal with the topic leaves a gap in our understanding of operant functional relations. A partial solution is to reintroduce the concept of the establishing operation, defined as an environmental event, operation, or stimulus condition that affects an organism by momentarily altering (a) the reinforcing effectiveness of other events and (b) the frequency of occurrence of that part of the organism's repertoire relevant to those events as consequences. Discriminative and motivative variables can be distinguished as follows: The former are related to the differential availability of an effective form of reinforcement given a particular type of behavior; the latter are related to the differential reinforcing effectiveness of environmental events. An important distinction can also be made between unconditioned establishing operations (UEOs), such as food deprivation and painful stimulation, and conditioned establishing operations (CEOs) that depend on the learning history of the organism. One type of CEO is a stimulus that has simply been paired with a UEO and as a result may take on some of the motivative properties of that UEO. The warning stimulus in avoidance procedures is another important type of CEO referred to as reflexive because it establishes its own termination as a form of reinforcement and evokes the behavior that has accomplished such termination. Another CEO is closely related to the concept of conditional conditioned reinforcement and is referred to as a transitive CEO, because it establishes some other stimulus as a form of effective reinforcement and evokes the behavior that has produced that other stimulus. The multiple control of human

  5. Measurement of Persistent Organic Pollutants (POPs) in plastic resin pellets from remote islands : Toward establishment of baseline level for International Pellet Watch

    NASA Astrophysics Data System (ADS)

    Takada, H.; Heskett, M.; Yamashita, R.; Yuyama, M.; Itoh, M.; Geok, Y. B.; Ogata, Y.

    2011-12-01

    Plastic resin pellets collected from remote islands in open oceans (Canary, St. Helena, Cocos, Hawaii, Maui Islands and Barbados) were sorted and yellowing polyethylene (PE) pellets were measured for polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane and the degradation products (DDTs), and hexachlorocyclohexanes (HCHs) by gas chromatograph equipped with mass spectrometer (GC-MS) and with electron capture detector (GC-ECD). PCBs were detected from all the pellet samples, confirming the global dispersion of PCBs. Median concentrations of PCBs (sum of 13 congeners : CB-66, CB-101, CB-110, CB-118, CB-105, CB-149, CB-153, CB-138, CB-128, CB-187, CB-180, CB-170, CB-206) in the remote island pellets ranged from 0.1 to 10 ng/g-pellet. These were one to three orders of magnitude lower than those observed for pellets from industrialized coastal zones (hundreds ng/g in Los Angeles, Boston, Tokyo; Ogata et al., 2009). Because these remote islands are far (>100 km) from industrialized zones, these concentrations (i.e., 0.1 to 10 ng/g-pellet) can be regarded as global "baseline" level of PCB pollution. Concentrations of DDTs in the remote island pellets ranged from 0.2 to 5.5 ng/g-pellet. At some locations, DDT was dominant over the degradation products (DDE and DDD), suggesting current usage of the pesticides in the islands. HCHs concentrations were 0.4 - 1.8 ng/g-pellet and lower than PCBs and DDTs, except for St. Helena Island at 18.8 ng/g-pellet where the current usage of the pesticides are of concern. The analyses of pellets from the remote islands provided "baseline" level of POPs (PCBs < 10 ng/g-pellet, DDTs < 6 ng/g-pellet, HCHs < 2 ng/g-pellet). However, the present samples were from tropical and subtropical areas. To establish global baseline, especially to understand the effects of global distillation, pellet samples from remote islands in higher latitude regions are necessary. From the eco-toxicological point of view, the fact that sporadic high

  6. A comparison of iterative explicit guidance algorithms for space launch vehicles

    NASA Astrophysics Data System (ADS)

    Song, Eun-Jung; Cho, Sangbum; Roh, Woong-Rae

    2015-01-01

    This paper analyzes and compares the performance of two prominent explicit guidance algorithms: the iterative guidance mode and the powered explicit guidance. We performed a series of numerical simulations of a space launch vehicle model for both nominal and off-nominal conditions. One of our findings is that if we take into account the originally ignored higher-order terms from the guidance parameters of the iterative guidance mode for a long-range flight, the guidance performance can be enhanced to a level comparable to that of the powered explicit guidance. These higher-order terms can be included by employing an iterative predictor-corrector method like the powered explicit guidance. Also we proposed a remedy of preventing relatively earlier divergence of the guidance commands with the predictor-corrector iteration than that of the linear differential corrector approach by making a better initial guess.

  7. Correcting for Visuo-Haptic Biases in 3D Haptic Guidance

    PubMed Central

    Kuling, Irene A.; Brenner, Eli; Bergmann Tiest, Wouter M.; Kappers, Astrid M. L.

    2016-01-01

    Visuo-haptic biases are observed when bringing your unseen hand to a visual target. The biases are different between, but consistent within participants. We investigated the usefulness of adjusting haptic guidance to these user-specific biases in aligning haptic and visual perception. By adjusting haptic guidance according to the biases, we aimed to reduce the conflict between the modalities. We first measured the biases using an adaptive procedure. Next, we measured performance in a pointing task using three conditions: 1) visual images that were adjusted to user-specific biases, without haptic guidance, 2) veridical visual images combined with haptic guidance, and 3) shifted visual images combined with haptic guidance. Adding haptic guidance increased precision. Combining haptic guidance with user-specific visual information yielded the highest accuracy and the lowest level of conflict with the guidance at the end point. These results show the potential of correcting for user-specific perceptual biases when designing haptic guidance. PMID:27438009

  8. Establishing baseline levels of trace elements in blood and skin of bottlenose dolphins in Sarasota Bay, Florida: implications for non-invasive monitoring.

    PubMed

    Bryan, Colleen E; Christopher, Steven J; Balmer, Brian C; Wells, Randall S

    2007-12-15

    Several major unusual mortality events occurring in recent years have increased the level of concern for the health of bottlenose dolphin populations along the United States Atlantic and Gulf of Mexico coasts. Trace element concentrations were examined in a population of free-ranging dolphins in Sarasota Bay, Florida, in order to develop a benchmark for future comparisons within and between populations. Whole blood (n=51) and skin (n=40) samples were collected through capture and release health assessment events during 2002-2004. Samples were analyzed for Al, V, Cr, Mn, Cu, Zn, As, Se, Rb, Sr, Mo, Cd, and Pb by inductively coupled plasma mass spectrometry (ICPMS) and Hg via atomic fluorescence spectrometry (AFS). Trace element concentrations (wet mass) in skin were 2 to 45 times greater than blood, except Cu was approximately 1.5 times higher in blood. Statistically strong correlations (p<0.05) were found for V, As, Se, Rb, Sr, and Hg between blood and skin demonstrating that these tissues can be used as effective non-lethal monitoring tools. The strongest correlation was established for Hg (r=0.9689) and concentrations in both blood and skin were above the threshold at which detrimental effects are observed in other vertebrate species. Female dolphins had significantly greater Hg concentrations in blood and skin and Pb concentrations in skin, relative to males. Calves exhibited significantly lower V, As, and Hg concentrations in blood and V and Hg concentrations in skin, relative to other age classes. Rubidium and Cu concentrations in skin were greatest in subadults and calves, respectively. In blood, V, Zn, and As concentrations were significantly greater in winter, relative to summer, and the opposite trend was observed for Rb and Sr concentrations. In skin, Cu and Zn concentrations were significantly greater in winter, relative to summer, and the opposite trend was observed for Mn, Rb, Cd, and Pb concentrations. The baseline concentrations and trends

  9. Guidance of Nonlinear Systems

    NASA Technical Reports Server (NTRS)

    Meyer, George

    1997-01-01

    The paper describes a method for guiding a dynamic system through a given set of points. The paradigm is a fully automatic aircraft subject to air traffic control (ATC). The ATC provides a sequence of way points through which the aircraft trajectory must pass. The way points typically specify time, position, and velocity. The guidance problem is to synthesize a system state trajectory which satisfies both the ATC and aircraft constraints. Complications arise because the controlled process is multi-dimensional, multi-axis, nonlinear, highly coupled, and the state space is not flat. In addition, there is a multitude of possible operating modes, which may number in the hundreds. Each such mode defines a distinct state space model of the process by specifying the state space coordinatization, the partition of the controls into active controls and configuration controls, and the output map. Furthermore, mode transitions must be smooth. The guidance algorithm is based on the inversion of the pure feedback approximations, which is followed by iterative corrections for the effects of zero dynamics. The paper describes the structure and modules of the algorithm, and the performance is illustrated by several example aircraft maneuvers.

  10. Guidance of Nonlinear Systems

    NASA Technical Reports Server (NTRS)

    Meyer, George; Null, Cynthia H. (Technical Monitor)

    1996-01-01

    The paper describes a method for guiding a dynamic system through a given set of points. The paradigm is a fully automatic aircraft subject to air traffic control (ATC). The ATC provides a sequence of way points through which the aircraft trajectory must pass. The way points typically specify time, position, and velocity. The guidance problem is to synthesize a system state trajectory which satisfies both the ATC and aircraft constraints. Complications arise because the controlled process is multi-dimensional, multi-axis, nonlinear, highly coupled, and the state space is not flat. In addition, there is a multitude of possible operating modes, which may number in the hundreds. Each such mode defines a distinct state space model of the process by specifying the state space coordination, the partition of the controls into active controls and configuration controls, and the output map. Furthermore, mode transitions must be smooth. The guidance algorithm is based on the inversion of the pure feedback approximations, which is followed by iterative corrections for the effects of zero dynamics. The paper describes the structure and modules of the algorithm, and the performance is illustrated by several example aircraft maneuvers.

  11. Controls and guidance: Space

    NASA Technical Reports Server (NTRS)

    Dibattista, John D.

    1988-01-01

    The Space Controls and Guidance Research and Technology Program is directed toward enabling the next generation of space transportation systems, large future spacecraft, and space systems such as the Space Station to have large communication antennas and high precision segmented reflector astrophysical telescopes. The new generation of transportation vehicles has demanding requirements to provide for an order of magnitude reduction in cost as well as an increase in capability. The future orbital facilities have demanding control requirements for pointing and stabilization, momentum management, build-up and growth accomodation, and disturbance management. To address these advanced requirements, the research and development program is designed to provide the generic technology base to support the implementation of advanced guidance, navigation, and control. The area of computational controls will be stressed in order to develop cost effective, high speed, high fidelity control system simulation and analysis and synthesis tools. The trust of this work will be to develop methods and software to enable analysis and real-time hardware-in-the-loop simulation of complex spacecraft for control design certification. To address future orbital facilities requirements, an advanced technology program is underway in system identification, distributed control, integrated controls/structures design methods, and advanced sensors and actuators. Because the behavior of large, light weight per unit area deployable/assembled spacecraft is greatly influenced by the ground environment, the testing and verification activity is both ground- and space-based.

  12. Bilinear tangent yaw guidance

    NASA Technical Reports Server (NTRS)

    Brusch, R. G.

    1979-01-01

    This paper presents a parametric yaw steering law which has been used to provide closed-loop yaw guidance for the launch of the HEAO (High Energy Astronomy Observatory) satellite mission using the Atlas/Centaur launch vehicle. This bilinear tangent steering law provides near optimal yaw steering for maneuvers requiring insertion into orbits with a specified inclination and node. Bilinear tangent steering is shown to be optimal in both the pitch and yaw planes when a uniform gravitational field is assumed. The conditions under which the general bilinear tangent laws degenerate into linear tangent and constant attitude laws are presented. The flight computer implementation of these laws in a rotating coordinate system using real-time integration of the equations of motion is detailed. Explicit solution of the parametric guidance equations requires the inflight solution of (2x2) two-point boundary value problems in the pitch and yaw planes. Excellent results are obtained even for very large (greater than 50 deg) out-of-plane steering angles.

  13. Partial stabilization-based guidance.

    PubMed

    Shafiei, M H; Binazadeh, T

    2012-01-01

    A novel nonlinear missile guidance law against maneuvering targets is designed based on the principles of partial stability. It is demonstrated that in a real approach which is adopted with actual situations, each state of the guidance system must have a special behavior and asymptotic stability or exponential stability of all states is not realistic. Thus, a new guidance law is developed based on the partial stability theorem in such a way that the behaviors of states in the closed-loop system are in conformity with a real guidance scenario that leads to collision. The performance of the proposed guidance law in terms of interception time and control effort is compared with the sliding mode guidance law by means of numerical simulations.

  14. Guidance for UMTRA project surveillance and maintenance

    SciTech Connect

    1986-01-01

    The Guidance for UMTRA Project Surveillance and Maintenance describes the procedures that will be used to verify that Uranium Mill Tailings Remedial Action (UMTRA) Project disposal sites continue to function as designed. The approach of this guidance document is to identify surveillance requirements and maintenance procedures that will be used to comply with NRC license requirements. This document addresses five primary activities: Definition and characterization of final site conditions. Site inspections; Ground-water monitoring; Aerial photography; and Custodial maintenance and contingency repair. Final site conditions will be defined and characterized prior to the completion of remedial actions at a site. As-built drawings will be compiled, a final topographic survey will be performed, a vicinity map will be prepared, and ground and aerial photographs will be taken. Survey monuments, site markers, and signs will be established as will a network of monitoring wells.

  15. Beyond Discipline to Guidance: A Primer on the Guidance Alternative.

    ERIC Educational Resources Information Center

    Gartrell, Dan

    As early childhood teachers apply principles of guidance rather than punishment in their classrooms, they face the challenge of avoiding a slippage into traditional discipline practices and transcending the punitive aspects of discipline. Guidance is designed to teach children democratic life skills and therefore goes beyond discipline. Teachers…

  16. The Talos guidance system

    NASA Astrophysics Data System (ADS)

    Gulick, J.; Hyatt, W. C.; Martin, O. M., Jr.

    1982-06-01

    A description is given of the design principles and performance capabilities of the Talos surface-to-air missile's homing system, which over the course of its development came to be virtually unjammable, as well as the associated antiradiation seeker, which enables the Talos to operate against radar signal-emitting targets. The interferometric homing system chosen employs widely spaced, airframe-fixed antennas compatible with ramjet inlet geometry and simpler than the alternative gimballed dish antenna. Early Talos missile guidance systems used scanning interferometry, but for subsequent models a continuous wave interferometer was developed, followed by a monopulse seeker. Attention is given to the use of the Talos system as a long range antiradiation missile for radar suppression in the Vietnam conflict.

  17. Guidance: Agent of the Counterculture.

    ERIC Educational Resources Information Center

    Patouillet, Raymond A.; Marin, Roselyn L.

    1979-01-01

    This article was an introduction to a convention program presented at the Florida Personnel and Guidance Association Convention (Tampa, Nov., 1977) by Raymond Patouillet, shortly before his sudden death. It encapsulates his guidance philosophy, his understanding of the human condition, and his faith in the crucial role of the caring profession.…

  18. Innovative Approaches to Career Guidance.

    ERIC Educational Resources Information Center

    Freeman, Andrew R.

    A key part of a broad-based approach to career education in Australian schools is vocational/career guidance. Various vocational guidance programs have been developed for specific groups in Australian society, including work experience, caravans, and micrographics technology for the handicapped; pre-employment courses and a family education center…

  19. Automated Guidance for Student Inquiry

    ERIC Educational Resources Information Center

    Gerard, Libby F.; Ryoo, Kihyun; McElhaney, Kevin W.; Liu, Ou Lydia; Rafferty, Anna N.; Linn, Marcia C.

    2016-01-01

    In 4 classroom experiments we investigated uses for technologies that automatically score student generated essays, concept diagrams, and drawings in inquiry curricula. We used the automatic scores to assign typical and research-based guidance and studied the impact of the guidance on student progress. Seven teachers and their 897 students…

  20. Considerations for Middle School Guidance

    ERIC Educational Resources Information Center

    Knudsen, Grace

    1971-01-01

    Middle school guidance appears to be neglected. Yet this is a time of searching when pupils who are able to relate are usually willing to be helped. The characteristics of both elementary and secondary school guidance need to be evaluated in order to provide continuity in the junior high schools. (Author/BY)

  1. Guidance Services in Spanish Universities

    ERIC Educational Resources Information Center

    Vidal, Javier; Diez, Gloria; Vieira, Maria J.

    2003-01-01

    Since the 80s, higher education in Spain has undergone important modifications such as greater autonomy, expansion in the number of students and the introduction of more flexible programmes. In this context, guidance services have proliferated in an unstructured way. This paper presents a description of guidance services in Spanish universities…

  2. Guidance in the Secondary School

    ERIC Educational Resources Information Center

    Kumar, V. Jurist Lional

    2010-01-01

    Secondary School Students face a lot of problems in their body as well as in mind due to puberty that tends to adolescence stage. Adolescence has peculiar characters of their own. They need proper Guidance and Counselling to tackle their own problems. Guidance is described as a counselling service to assist the individual in achieving self…

  3. A Guide to Career Guidance.

    ERIC Educational Resources Information Center

    Nejedlo, Robert J., Ed.

    The nineteen articles in this guidebook are by former consultants for vocational guidance workshops at Northern Illinois University. Articles are organized in five parts: identifying students' career guidance needs, providing students with helpful career information, assisting students pursuing career programs, preparing students for career…

  4. Signaling from Axon Guidance Receptors

    PubMed Central

    Bashaw, Greg J.; Klein, Rüdiger

    2010-01-01

    Determining how axon guidance receptors transmit signals to allow precise pathfinding decisions is fundamental to our understanding of nervous system development and may suggest new strategies to promote axon regeneration after injury or disease. Signaling mechanisms that act downstream of four prominent families of axon guidance cues—netrins, semaphorins, ephrins, and slits—have been extensively studied in both invertebrate and vertebrate model systems. Although details of these signaling mechanisms are still fragmentary and there appears to be considerable diversity in how different guidance receptors regulate the motility of the axonal growth cone, a number of common themes have emerged. Here, we review recent insights into how specific receptors for each of these guidance cues engage downstream regulators of the growth cone cytoskeleton to control axon guidance. PMID:20452961

  5. Signaling from axon guidance receptors.

    PubMed

    Bashaw, Greg J; Klein, Rüdiger

    2010-05-01

    Determining how axon guidance receptors transmit signals to allow precise pathfinding decisions is fundamental to our understanding of nervous system development and may suggest new strategies to promote axon regeneration after injury or disease. Signaling mechanisms that act downstream of four prominent families of axon guidance cues--netrins, semaphorins, ephrins, and slits--have been extensively studied in both invertebrate and vertebrate model systems. Although details of these signaling mechanisms are still fragmentary and there appears to be considerable diversity in how different guidance receptors regulate the motility of the axonal growth cone, a number of common themes have emerged. Here, we review recent insights into how specific receptors for each of these guidance cues engage downstream regulators of the growth cone cytoskeleton to control axon guidance. PMID:20452961

  6. RH Packaging Program Guidance

    SciTech Connect

    Washington TRU Solutions LLC

    2008-01-12

    The purpose of this program guidance document is to provide the technical requirements for use, operation, inspection, and maintenance of the RH-TRU 72-B Waste Shipping Package (also known as the "RH-TRU 72-B cask") and directly related components. This document complies with the requirements as specified in the RH-TRU 72-B Safety Analysis Report for Packaging (SARP), and Nuclear Regulatory Commission (NRC) Certificate of Compliance (C of C) 9212. If there is a conflict between this document and the SARP and/or C of C, the C of C shall govern. The C of C states: "...each package must be prepared for shipment and operated in accordance with the procedures described in Chapter 7.0, Operating Procedures, of the application." It further states: "...each package must be tested and maintained in accordance with the procedures described in Chapter 8.0, Acceptance Tests and Maintenance Program of the Application." Chapter 9.0 of the SARP tasks the Waste Isolation Pilot Plant (WIPP) Management and Operating (M&O) Contractor with assuring the packaging is used in accordance with the requirements of the C of C. Because the packaging is NRC-approved, users need to be familiar with Title 10 Code of Federal Regulations (CFR) §71.8, "Deliberate Misconduct." Any time a user suspects or has indications that the conditions of approval in the C of C were not met, the U.S. Department of Energy (DOE) Carlsbad Field Office (CBFO) shall be notified immediately. The CBFO will evaluate the issue and notify the NRC if required.In accordance with 10 CFR Part 71, "Packaging and Transportation of Radioactive Material," certificate holders, packaging users, and contractors or subcontractors who use, design, fabricate, test, maintain, or modify the packaging shall post copies of (1) 10 CFR Part 21, "Reporting of Defects and Noncompliance," regulations, (2) Section 206 of the Energy Reorganization Act of 1974, and (3) NRC Form 3, Notice to Employees. These documents must be posted in a

  7. Autonomous landing guidance program

    NASA Astrophysics Data System (ADS)

    Brown, John A.

    1996-05-01

    The Autonomous Landing Guidance program is partly funded by the US Government under the Technology Reinvestment Project. The program consortium consists of avionics and other equipment vendors, airlines and the USAF. A Sextant Avionique HUD is used to present flight symbology in cursive form as well as millimeter wave radar imagery from Lear Astronics equipment and FLIR Systems dual-channel, forward-looking, infrared imagery. All sensor imagery is presented in raster form. A future aim is to fuse all imagery data into a single presentation. Sensor testing has been accomplished in a Cessna 402 operated by the Maryland Advanced Development Laboratory. Development testing is under way in a Northwest Airlines simulator equipped with HUD and image simulation. Testing is also being carried out using United Airlines Boeing 727 and USAF C-135C (Boeing 707) test aircraft. The paper addresses the technology utilized in sensory and display systems as well as modifications made to accommodate the elements in the aircraft. Additions to the system test aircraft include global positioning systems, inertial navigation systems and extensive data collection equipment. Operational philosophy and benefits for both civil and military users are apparent. Approach procedures have been developed allowing use of Category 1 ground installations in Category 3 conditions.

  8. 23 CFR 630.1012 - Project-level procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Features for Work Zones” 2002, is incorporated by reference in accordance with 5 U.S.C. 552(a) and 1 CFR... PRECONSTRUCTION PROCEDURES Work Zone Safety and Mobility § 630.1012 Project-level procedures. (a) This section provides guidance and establishes procedures for States to manage the work zone impacts of...

  9. Establishing Behavioral and Assessment Criteria through the Use of a Behavioral Level System for Dealing with Self Contained EH Elementary School Children.

    ERIC Educational Resources Information Center

    Vogelmann-Peper, Marcella

    This practicum was designed to establish behavioral and assessment criteria for dealing with seriously emotionally disturbed elementary students enrolled in self-contained emotionally handicapped (EH) units. A primary goal was to provide out-of-field EH teachers with an objective tool for continuously assessing students' individual behavioral and…

  10. Asbestos/NESHAP adequately wet guidance

    SciTech Connect

    Shafer, R.; Throwe, S.; Salgado, O.; Garlow, C.; Hoerath, E.

    1990-12-01

    The Asbestos NESHAP requires facility owners and/or operators involved in demolition and renovation activities to control emissions of particulate asbestos to the outside air because no safe concentration of airborne asbestos has ever been established. The primary method used to control asbestos emissions is to adequately wet the Asbestos Containing Material (ACM) with a wetting agent prior to, during and after demolition/renovation activities. The purpose of the document is to provide guidance to asbestos inspectors and the regulated community on how to determine if friable ACM is adequately wet as required by the Asbestos NESHAP.

  11. Design and Testing of a Low Noise Flight Guidance Concept

    NASA Technical Reports Server (NTRS)

    Williams, David H.; Oseguera-Lohr, Rosa M.; Lewis, Elliot T.

    2004-01-01

    A flight guidance concept was developed to assist in flying continuous descent approach (CDA) procedures designed to lower the noise under the flight path of jet transport aircraft during arrival operations at an airport. The guidance consists of a trajectory prediction algorithm that was tuned to produce a high-efficiency, low noise flight profile with accompanying autopilot and flight display elements needed by the flight control system and pilot to fly the approach. A key component of the flight guidance was a real-time display of energy error relative to the predicted flight path. The guidance was integrated with the conventional Flight Management System (FMS) guidance of a modern jet transport airplane and tested in a high fidelity flight simulation. A charted arrival procedure, which allowed flying conventional arrivals, CDA arrivals with standard guidance, and CDA arrivals with the new low noise guidance, was developed to assist in the testing and evaluation of the low noise guidance concept. Results of the simulation testing showed the low noise guidance was easy to use by airline pilot test subjects and effective in achieving the desired noise reduction. Noise under the flight path was reduced by at least 2 decibels in Sound Exposure Level (SEL) at distances from about 3 nautical miles out to about 17.5 nautical miles from the runway, with a peak reduction of 8.5 decibels at about 10.5 nautical miles. Fuel consumption was also reduced by about 17% for the LNG conditions compared to baseline runs for the same flight distance. Pilot acceptance and understanding of the guidance was quite high with favorable comments and ratings received from all test subjects.

  12. Guidance on Dependence Assessment in SPAR-H

    SciTech Connect

    April M. Whaley

    2012-06-01

    As part of the effort to develop the SPAR-H user guidance, particular attention was paid to the assessment of dependence in order to address user questions about proper application of dependence. This paper presents a discussion of dependence from a psychological perspective and provides guidance on applying this information during the qualitative analysis of dependence to ensure more realistic and appropriate dependence assessments with the SPAR-H method. While this guidance was developed with SPAR-H in mind, it may be informative to other human reliability analysis methods that also use a THERP-based dependence approach, particularly if applied at the human failure event level.

  13. Connecting the eye to the brain: the molecular basis of ganglion cell axon guidance

    PubMed Central

    Oster, S F; Sretavan, D W

    2003-01-01

    In the past several years, a great deal has been learnt about the molecular basis through which specific neural pathways in the visual system are established during embryonic development. This review provides a framework for understanding the principles of retinal ganglion cell axon guidance, and introduces some of the families of axon guidance molecules involved. In addition, the potential relevance of retinal axon guidance to human visual developmental disorders, and to retinal axon regeneration, is discussed. PMID:12714414

  14. 76 FR 23823 - Guidance for Industry on Fish and Fishery Products Hazards and Controls, Fourth Edition...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... control recommendations are listed for the natural toxin action level for diarrhetic shellfish poisoning... the third edition to include ciguatera fish poisoning guidance for northern Gulf of Mexico...

  15. Video guidance, landing, and imaging systems

    NASA Technical Reports Server (NTRS)

    Schappell, R. T.; Knickerbocker, R. L.; Tietz, J. C.; Grant, C.; Rice, R. B.; Moog, R. D.

    1975-01-01

    The adaptive potential of video guidance technology for earth orbital and interplanetary missions was explored. The application of video acquisition, pointing, tracking, and navigation technology was considered to three primary missions: planetary landing, earth resources satellite, and spacecraft rendezvous and docking. It was found that an imaging system can be mechanized to provide a spacecraft or satellite with a considerable amount of adaptability with respect to its environment. It also provides a level of autonomy essential to many future missions and enhances their data gathering ability. The feasibility of an autonomous video guidance system capable of observing a planetary surface during terminal descent and selecting the most acceptable landing site was successfully demonstrated in the laboratory. The techniques developed for acquisition, pointing, and tracking show promise for recognizing and tracking coastlines, rivers, and other constituents of interest. Routines were written and checked for rendezvous, docking, and station-keeping functions.

  16. 40 CFR Table 8 to Subpart Jjj of... - Operating Parameters for Which Levels Are Required To Be Established for Continuous and Batch...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 8 Table 8 to Subpart JJJ of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY.... 63, Subpt. JJJ, Table 8 Table 8 to Subpart JJJ of Part 63—Operating Parameters for Which Levels...

  17. Hubble Space Telescope fine-guidance-sensor transfer function and its impact on telescope alignment and guidance.

    PubMed

    Ftaclas, C; Basedow, R; Nonnenmacher, A; Weindling, F; Story, D; Nelan, E

    1993-04-01

    We describe the use of Hubble Space Telescope Fine Guidance Sensor transfer scans to characterize telescope alignment. To accomplish this we developed a software system to extract the aberration content from the observed transfer scans. The transfer scans show large aberration levels that do not originate in the telescope. The appearance of significant coma in the transfer scans has been identified as resulting from the shearing of spherical aberration caused by a beam misalignment within the Fine Guidance Sensors themselves.

  18. Developing & Managing Your School Guidance & Counseling Program. Fifth Edition

    ERIC Educational Resources Information Center

    Gysbers, Norman C.; Henderson, Patricia

    2012-01-01

    Five phases for establishing and improving Pre-K-12 comprehensive guidance and counseling programs serve as the organizational framework for this enduring, influential textbook written for counselor educators and their students, school leaders, practicing school counselors, and state or district supervisors. The fifth edition of this bestseller…

  19. A SUPPLEMENTAL GUIDANCE MANUAL BASED ON INSTITUTIONAL REASEARCH.

    ERIC Educational Resources Information Center

    NIELSEN, MARJORIE L.

    THE GUIDANCE MANUAL HAS BEEN ORGANIZED TO PROVIDE A STATISTICAL BASIS FOR ANALYZING (1) THE NONSELECTIVE ADMISSION POLICY, (2) THE PERFORMANCE OF NATIVE, EVERETT JUNIOR COLLEGE STUDENTS WHO TRANSFER TO 4-YEAR COLLEGES, (3) THE PERFORMANCE OF TRANSFER STUDENTS TO THE JUNIOR COLLEGE WHO LATER ENROLL AT A 4-YEAR COLLEGE, (4) THE ESTABLISHMENT OF THE…

  20. Parental Guidance about Drinking: Relationship with Teenage Psychoactive Substance Use

    ERIC Educational Resources Information Center

    Miller, Patrick; Plant, Martin

    2010-01-01

    Parental guidance concerning alcohol was explored using data from a 2007 survey of 2179 UK school students aged 15 and 16 years. Cluster analysis based on questions about parental advice was used to establish seven student groups. Associations between groups, other family background and psychoactive substance use variables were explored. Substance…

  1. Child Guidance and Mental Health in the Netherlands

    ERIC Educational Resources Information Center

    Bakker, Nelleke

    2006-01-01

    In the Netherlands, as in the United States, the introduction of the concept of "mental health" in education is closely related to the development of a network of child guidance clinics. The first of these was established in Amsterdam in 1928. However, a substantial movement to actively promote mental health did not come into existence until after…

  2. 76 FR 411 - Regulatory Guidance Concerning Electronic Signatures and Documents

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... produced within two working days of a request (62 FR 16370). FMCSA rescinds that interpretation and motor... or documents Rescind existing Questions 1 and 2 (62 FR 16370), retain existing Questions 3 and 4... of losing or altering data). Today's guidance establishes parity between paper and electronic...

  3. microRNAs in axon guidance

    PubMed Central

    Iyer, Archana N.; Bellon, Anaïs; Baudet, Marie-Laure

    2014-01-01

    Brain wiring is a highly intricate process in which trillions of neuronal connections are established. Its initial phase is particularly crucial in establishing the general framework of neuronal circuits. During this early step, differentiating neurons extend axons, which reach their target by navigating through a complex environment with extreme precision. Research in the past 20 years has unraveled a vast and complex array of chemotropic cues that guide the leading tip of axons, the growth cone, throughout its journey. Tight regulation of these cues, and of their receptors and signaling pathways, is necessary for the high degree of accuracy required during circuit formation. However, little is known about the nature of regulatory molecules or mechanisms fine-tuning axonal cue response. Here we review recent, and somewhat fragmented, research on the possibility that microRNAs (miRNAs) could be key fine-tuning regulatory molecules in axon guidance. miRNAs appear to shape long-range axon guidance, fasciculation and targeting. We also present several lines of evidence suggesting that miRNAs could have a compartmentalized and differential action at the cell soma, and within axons and growth cones. PMID:24672429

  4. 77 FR 70167 - Draft Guidance for Industry on Vaginal Microbicides: Development for the Prevention of Human...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-23

    ... guidance outlines the types of nonclinical studies and clinical trials recommended throughout the drug... collections of information referred to in the guidance for clinical trial sponsors entitled ``Establishment and Operation of Clinical Trial Data Monitoring Committees'' have been approved under OMB...

  5. 75 FR 41452 - Draft Guidance, “Federal Greenhouse Gas Accounting and Reporting”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... peer-reviewed life cycle methodologies is beyond the scope of the current version of this guidance... request comment on inclusion of life cycle methodologies in future versions of this Guidance document. CEQ... Leadership in Environmental, Energy, and Economic Performance (74 FR 52117) in order to establish...

  6. 75 FR 49913 - Draft Guidance, “Federal Greenhouse Gas Accounting and Reporting”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-16

    ... peer-reviewed life cycle methodologies is beyond the scope of the current version of this guidance... request comment on inclusion of life cycle methodologies in future versions of this Guidance document. CEQ..., Energy, and Economic Performance (74 FR 52117) in order to establish an integrated strategy...

  7. Guidelines for Self-Study of a School District Guidance Program.

    ERIC Educational Resources Information Center

    Pennsylvania State Dept. of Education, Harrisburg. Bureau of Instructional Support Services.

    Self-study is described as a process wherein local school district guidance staffs, with the aid of consultants if needed, determine the objectives for guidance services within a local setting and establish methods by which those objectives can be met most effectively. Program objectives and related activities are formulated only after sufficient…

  8. Guidance and Advisement Programs Are Proof That Schools Want Their Students to Succeed

    ERIC Educational Resources Information Center

    Southern Regional Education Board (SREB), 2009

    2009-01-01

    This newsletter of best practices describes steps that schools have taken to establish a guidance and advisement system that helps students plan for and succeed in students high school, further study and careers. Articles in this issue include: (1) Advisory Program Boosts Achievement and Career Planning; (2) District-Wide Guidance Program Assists…

  9. WIPP waste characterization program sampling and analysis guidance manual

    SciTech Connect

    Not Available

    1991-01-01

    The Waste Isolation Pilot Plant (WIPP) Waste Characterization Program Sampling and Analysis Guidance Manual (Guidance Manual) provides a unified source of information on the sampling and analytical techniques that enable Department of Energy (DOE) facilities to comply with the requirements established in the current revision of the Quality Assurance Program Plan (QAPP) for the WIPP Experimental-Waste Characterization Program (the Program). This Guidance Manual includes all of the sampling and testing methodologies accepted by the WIPP Project Office (DOE/WPO) for use in implementing the Program requirements specified in the QAPP. This includes methods for characterizing representative samples of transuranic (TRU) wastes at DOE generator sites with respect to the gas generation controlling variables defined in the WIPP bin-scale and alcove test plans, as well as waste container headspace gas sampling and analytical procedures to support waste characterization requirements under the WIPP test program and the Resource Conservation and Recovery Act (RCRA). The procedures in this Guidance Manual are comprehensive and detailed and are designed to provide the necessary guidance for the preparation of site specific procedures. The use of these procedures is intended to provide the necessary sensitivity, specificity, precision, and comparability of analyses and test results. The solutions to achieving specific program objectives will depend upon facility constraints, compliance with DOE Orders and DOE facilities' operating contractor requirements, and the knowledge and experience of the TRU waste handlers and analysts. With some analytical methods, such as gas chromatography/mass spectrometry, the Guidance Manual procedures may be used directly. With other methods, such as nondestructive/destructive characterization, the Guidance Manual provides guidance rather than a step-by-step procedure.

  10. Establishing geochemical background levels of selected trace elements in areas having geochemical anomalies: The case study of the Orbetello lagoon (Tuscany, Italy).

    PubMed

    Romano, Elena; Bergamin, Luisa; Croudace, Ian W; Ausili, Antonella; Maggi, Chiara; Gabellini, Massimo

    2015-07-01

    The determination of background concentration values (BGVs) in areas, characterised by the presence of natural geochemical anomalies and anthropogenic impact, appears essential for a correct pollution assessment. For this purpose, it is necessary to establish a reliable method for determination of local BGVs. The case of the Orbetello lagoon, a geologically complex area characterized by Tertiary volcanism, is illustrated. The vertical concentration profiles of As, Cd, Cr, Cu, Hg, Ni, Pb and Zn were studied in four sediment cores. Local BGVs were determined considering exclusively samples not affected by anthropogenic influence, recognized by means of multivariate statistics and radiochronological dating ((137)Cs and (210)Pb). Results showed BGVs well-comparable with mean crustal or shale values for most of the considered elements except for Hg (0.87 mg/kg d.w.) and As (16.87 mg/kg d.w.), due to mineralization present in the catchment basin draining into the lagoon.

  11. Measuring Client Progression in Adult Guidance

    ERIC Educational Resources Information Center

    Hearne, Lucy

    2007-01-01

    Currently, in the field of guidance, relevant stakeholders including guidance practitioners, educators and policy makers, have identified progression for adults in education and employment as one of the key outcomes of educational guidance. Lifelong guidance is now inextricably linked with lifelong learning as a mechanism to enhance individual…

  12. 33 CFR 385.5 - Guidance memoranda.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., Circulars, Manuals, or Pamphlets, or other appropriate form of guidance. (2) Guidance on the following six... for development of six program-wide guidance memoranda. The Corps of Engineers and the South Florida... agencies, develop the six guidance memoranda described in paragraph (a) of this section for approval by...

  13. Vocational Guidance: A Primary Function of Education.

    ERIC Educational Resources Information Center

    Roehrs, Hermann

    1992-01-01

    Perceives vocational orientation/guidance as a school responsibility. Discusses changing work attitudes, vocational guidance as counseling for life, parents' roles, work experience for 14-16 year olds, continuity between vocational guidance and competent career choice, vocational ethics, and midcareer and retirement guidance. Cites research on…

  14. Information Paper 18: Guidance in Secondary Schools.

    ERIC Educational Resources Information Center

    Ashton, Terry

    1986-01-01

    Traces impetus for introduction of structured guidance into Scottish secondary schools. Identifies 1968 "Orange Paper" as first attempt to set out rationale for guidance. Describes how guidance is organized; outlines tasks of guidance teachers; and presents current developments, training requirements, and trends. (NEC)

  15. Guidelines for Comprehensive Guidance and Counseling Services.

    ERIC Educational Resources Information Center

    Stefkovich, Jacqueline; And Others

    These guidelines are designed to assist local school districts and their Boards of Education in developing and implementing comprehensive guidance and counseling services in thier school systems. The components of the comprehensive guidance program are comprehensive guidance services, certified personnel, and comprehensive guidance facilities.…

  16. Resources for Guidance Program Improvement. Volume 2.

    ERIC Educational Resources Information Center

    Frenza, Mary C., Comp.; and Others

    This guide, for guidance personnel and teachers, is designed to provide ready access to current, practical programs, activities, and references for improving guidance programs. The resources are organized in four sections representing areas of basic concern for guidance personnel. Section 1 presents selected portions of guidance programs from…

  17. Establishing American Colleges Abroad.

    ERIC Educational Resources Information Center

    Greene, William E.

    1990-01-01

    Describes the growing involvement of U.S. two-year colleges in establishing programs abroad to enable foreign students to complete one or two years of college-level work in their home country before transferring to U.S. universities. Highlights the activities of several community colleges in the Pacific Rim. Identifies conditions basic to future…

  18. Direct measurement of oleocanthal and oleacein levels in olive oil by quantitative (1)H NMR. Establishment of a new index for the characterization of extra virgin olive oils.

    PubMed

    Karkoula, Evangelia; Skantzari, Angeliki; Melliou, Eleni; Magiatis, Prokopios

    2012-11-28

    A new method for direct measurement of the oleocanthal and oleacein levels in olive oil by quantitative (1)H NMR was developed. The method was applied to the study of 175 monovarietal commercial Greek and California olive oil samples. The main findings were as follows: (1) There was a significant variation concerning the concentrations of oleocanthal and oleacein among the studied samples. Their concentrations ranged from nondetectable to 355 mg/kg and their sum (index D1) from 0 to 501 mg/kg. (2) There are olive varieties that independent of geographic origin and harvest time produce oil that contains both compounds in low levels. (3) There is a positive correlation of a high level of oleocanthal and oleacein in olive oils with the early time of harvest. Although there is a need for more extensive study, a new index for the characterization of extra virgin olive oils, which is a combination of D1 = oleocanthal + oleacein level and D2 = oleocanthal/oleacein ratio, seems to be very useful. PMID:23116297

  19. Direct measurement of oleocanthal and oleacein levels in olive oil by quantitative (1)H NMR. Establishment of a new index for the characterization of extra virgin olive oils.

    PubMed

    Karkoula, Evangelia; Skantzari, Angeliki; Melliou, Eleni; Magiatis, Prokopios

    2012-11-28

    A new method for direct measurement of the oleocanthal and oleacein levels in olive oil by quantitative (1)H NMR was developed. The method was applied to the study of 175 monovarietal commercial Greek and California olive oil samples. The main findings were as follows: (1) There was a significant variation concerning the concentrations of oleocanthal and oleacein among the studied samples. Their concentrations ranged from nondetectable to 355 mg/kg and their sum (index D1) from 0 to 501 mg/kg. (2) There are olive varieties that independent of geographic origin and harvest time produce oil that contains both compounds in low levels. (3) There is a positive correlation of a high level of oleocanthal and oleacein in olive oils with the early time of harvest. Although there is a need for more extensive study, a new index for the characterization of extra virgin olive oils, which is a combination of D1 = oleocanthal + oleacein level and D2 = oleocanthal/oleacein ratio, seems to be very useful.

  20. The Effect of Classroom Teachers' Attitudes toward Constructivist Approach on Their Level of Establishing a Constructivist Learning Environment: A Case of Mersin

    ERIC Educational Resources Information Center

    Uredi, Lutfi

    2013-01-01

    This study aims to determine the attitudes of classroom teachers towards constructivist approach and to analyze the effect of their attitudes towards constructivist approach on their level of creating a constructivist learning environment. For that purpose, relational screening model was used in the research. The research sample included 504…

  1. Toward the establishment of standardized in vitro tests for lipid-based formulations, part 6: effects of varying pancreatin and calcium levels.

    PubMed

    Sassene, Philip; Kleberg, Karen; Williams, Hywel D; Bakala-N'Goma, Jean-Claude; Carrière, Frédéric; Calderone, Marilyn; Jannin, Vincent; Igonin, Annabel; Partheil, Anette; Marchaud, Delphine; Jule, Eduardo; Vertommen, Jan; Maio, Mario; Blundell, Ross; Benameur, Hassan; Porter, Christopher J H; Pouton, Colin W; Müllertz, Anette

    2014-11-01

    The impact of pancreatin and calcium addition on a wide array of lipid-based formulations (LBFs) during in vitro lipolysis, with regard to digestion rates and distribution of the model drug danazol, was investigated. Pancreatin primarily affected the extent of digestion, leaving drug distribution somewhat unaffected. Calcium only affected the extent of digestion slightly but had a major influence on drug distribution, with more drug precipitating at higher calcium levels. This is likely to be caused by a combination of removal of lipolysis products from solution by the formation of calcium soaps and calcium precipitating with bile acids, events known to reduce the solubilizing capacity of LBFs dispersed in biorelevant media. Further, during the digestion of hydrophilic LBFs, like IIIA-LC, the un-ionized-ionized ratio of free fatty acids (FFA) remained unchanged at physiological calcium levels. This makes the titration curves at pH 6.5 representable for digestion. However, caution should be taken when interpreting lipolysis curves of lipophilic LBFs, like I-LC, at pH 6.5, at physiological levels of calcium (1.4 mM); un-ionized-ionized ratio of FFA might change during digestion, rendering the lipolysis curve at pH 6.5 non-representable for the total digestion. The ratio of un-ionized-ionized FFAs can be maintained during digestion by applying non-physiological levels of calcium, resulting in a modified drug distribution with increased drug precipitation. However, as the main objective of the in vitro digestion model is to evaluate drug distribution, which is believed to have an impact on bioavailability in vivo, a physiological level (1.4 mM) of calcium is preferred. PMID:25274609

  2. Track 2 sites: Guidance for assessing low probability hazard sites at the INEL. Revision 6

    SciTech Connect

    Not Available

    1994-01-01

    This document presents guidance for assessment of Track 2 low probability hazard sites (LPHS) at the Idaho National Engineering Laboratory (INEL). The Track 2 classification was developed specifically for the INEL to streamline the implementation of Comprehensive Environmental Response, Compensation, and Liability Act. Track 2 LPHSs are described as sites where insufficient data are available to make a decision concerning the risk level or to select or design a remedy. As such, these types of sites are not described in the National Contingency Plan or existing regulatory guidance. The goal of the Track 2 process is to evaluate LPHSs using existing qualitative and quantitative data to minimize the collection of new environmental data. To this end, this document presents a structured format consisting of a series of questions and tables. A qualitative risk assessment is used. The process is iterative, and addresses an LPHS from multiple perspectives (i.e., historical, empirical, process) in an effort to generate a reproducible and defensible method. This rigorous approach follows the data quality objective process and establishes a well organized, logical approach to consolidate and assess existing data, and set decision criteria. If necessary, the process allows for the design of a sampling and analysis strategy to obtain new environmental data of appropriate quality to support decisions for each LPHS. Finally, the guidance expedites consensus between regulatory parties by emphasizing a team approach to Track 2 investigations.

  3. Effects of robotic guidance on the coordination of locomotion

    PubMed Central

    2013-01-01

    Background Functional integration of motor activity patterns enables the production of coordinated movements, such as walking. The activation of muscles by weightened summation of activation signals has been demonstrated to represent the spatiotemporal components that determine motor behavior during walking. Exoskeleton robotic devices are now often used in the rehabilitation practice to assist physical therapy of individuals with neurological disorders. These devices are used to promote motor recovery by providing guidance force to the patients. The guidance should in principle lead to a muscle coordination similar to physiological human walking. However, the influence of robotic devices on locomotor patterns needs still to be characterized. The aim of this study was to analyze the effect of force guidance and gait speed on the modular organization of walking in a group of eight healthy subjects. Method A group of healthy subjects walked on a treadmill with and without robotic aiding at speeds of 1.5, 2.0 and 2.5 Km/h. The guidance force was varied between 20%, 40%, 70% and 100% level of assistance. EMG recordings were obtained from seven leg muscles of the dominant leg and kinematic and kinetic features of the knee and hip joints were extracted. Results Four motor modules were sufficient to represent the variety of behavioral goals demanded during robotic guidance, with similar relationships between muscle patterns and biomechanical parameters across subjects, confirming that the low-dimensional and impulsive control of human walking is maintained using robotic force guidance. The conditions of guidance force and speed that maintained correct and incorrect (not natural) modular control were identified. Conclusion In neurologically intact subjects robotic-guided walking at various force guidance and speed levels does not alter the basic locomotor control and timing. This allows the design of robotic-aided rehabilitation strategies aimed at the modulation of motor

  4. Reference energy-altitude descent guidance: Simulator evaluation. [aircraft descent and fuel conservation

    NASA Technical Reports Server (NTRS)

    Abbot, K. H.; Knox, C. E.

    1985-01-01

    Descent guidance was developed to provide a pilot with information to ake a fuel-conservative descent and cross a designated geographical waypoint at a preselected altitude and airspeed. The guidance was designed to reduce fuel usage during the descent and reduce the mental work load associated with planning a fuel-conservative descent. A piloted simulation was conducted to evaluate the operational use of this guidance concept. The results of the simulation tests show that the use of the guidance reduced fuel consumption and mental work load during the descent. Use of the guidance also decreased the airspeed error, but had no effect on the altitude error when the designated waypoint was crossed. Physical work load increased with the use of the guidance, but remained well within acceptable levels. The pilots found the guidance easy to use as presented and reported that it would be useful in an operational environment.

  5. 75 FR 52427 - Guidance for Industry: Questions and Answers Regarding the Effect of Section 4205 of the Patient...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... requirements for nutrition labeling of standard menu items for chain retail food establishments and chain... menu items (``chain retail food establishments'') to disclose specific nutrition information about... HUMAN SERVICES Food and Drug Administration Guidance for Industry: Questions and Answers Regarding...

  6. Use of community-level data in the National Children’s Study to establish the representativeness of segment selection in the Queens Vanguard Site

    PubMed Central

    2012-01-01

    Background The WHO Multiple Exposures Multiple Effects (MEME) framework identifies community contextual variables as central to the study of childhood health. Here we identify multiple domains of neighborhood context, and key variables describing the dimensions of these domains, for use in the National Children’s Study (NCS) site in Queens. We test whether the neighborhoods selected for NCS recruitment, are representative of the whole of Queens County, and whether there is sufficient variability across neighborhoods for meaningful studies of contextual variables. Methods Nine domains (demographic, socioeconomic, households, birth rated, transit, playground/greenspace, safety and social disorder, land use, and pollution sources) and 53 indicator measures of the domains were identified. Geographic information systems were used to create community-level indicators for US Census tracts containing the 18 study neighborhoods in Queens selected for recruitment, using US Census, New York City Vital Statistics, and other sources of community-level information. Mean and inter-quartile range values for each indicator were compared for Tracts in recruitment and non-recruitment neighborhoods in Queens. Results Across the nine domains, except in a very few instances, the NCS segment-containing tracts (N = 43) were not statistically different from those 597 populated tracts in Queens not containing portions of NCS segments; variability in most indicators was comparable in tracts containing and not containing segments. Conclusions In a diverse urban setting, the NCS segment selection process succeeded in identifying recruitment areas that are, as a whole, representative of Queens County, for a broad range of community-level variables. PMID:22668454

  7. Developing the revised NICE appraisal technical guidance to manufacturers and sponsors: opportunity or threat?

    PubMed

    Taylor, Rod S; Hutton, John; Culyer, Anthony J

    2002-01-01

    One of the principal roles of the National Institute for Clinical Excellence (NICE) is to appraise selected existing and emerging healthcare technologies and, as a result, produce guidance for the National Health Service (NHS) in England and Wales. A central part of this appraisal is the potential for manufacturers and sponsors to make a data submission. This paper describes the process of development of the second edition of technical guidance to manufacturers and sponsors for submission to NICE. The revision process took place during the period May 2000 and January 2001 and involved a number of key steps -- establishment of a guidance steering committee, review of current international guidelines of clinical and cost effectiveness, drafting of the guidance, detailed consultation with stakeholders, revision of the guidance and, finally, publication. The lessons learnt from revision of the NICE guidance for manufacturers and sponsors and some main issues for its future development are discussed. PMID:12456199

  8. Establishing nuclear facility drill programs

    SciTech Connect

    1996-03-01

    The purpose of DOE Handbook, Establishing Nuclear Facility Drill Programs, is to provide DOE contractor organizations with guidance for development or modification of drill programs that both train on and evaluate facility training and procedures dealing with a variety of abnormal and emergency operating situations likely to occur at a facility. The handbook focuses on conducting drills as part of a training and qualification program (typically within a single facility), and is not intended to included responses of personnel beyond the site boundary, e.g. Local or State Emergency Management, Law Enforcement, etc. Each facility is expected to develop its own facility specific scenarios, and should not limit them to equipment failures but should include personnel injuries and other likely events. A well-developed and consistently administered drill program can effectively provide training and evaluation of facility operating personnel in controlling abnormal and emergency operating situations. To ensure the drills are meeting their intended purpose they should have evaluation criteria for evaluating the knowledge and skills of the facility operating personnel. Training and evaluation of staff skills and knowledge such as component and system interrelationship, reasoning and judgment, team interactions, and communications can be accomplished with drills. The appendices to this Handbook contain both models and additional guidance for establishing drill programs at the Department`s nuclear facilities.

  9. Autonomous Guidance, Navigation and Control

    NASA Astrophysics Data System (ADS)

    Bordano, A. J.; McSwain, G. G.; Fernandes, S. T.

    The NASA Autonomous Guidance, Navigation and Control (GN&C) Bridging program is reviewed to demonstrate the program plan and GN&C systems for the Space Shuttle. The ascent CN&C system is described in terms of elements such as the general-purpose digital computers, sensors for the navigation subsystem, the guidance-system software, and the flight-control subsystem. Balloon-based and lidar wind soundings are used for operations assessment on the day of launch, and the guidance software is based on dedicated units for atmospheric powered flight, vacuum powered flight, and abort-specific situations. Optimization of the flight trajectories is discussed, and flight-control responses are illustrated for wavelengths of 500-6000 m. Alternate sensors are used for load relief, and adaptive GN&C systems based on alternate gain synthesis are used for systems failures.

  10. Responding to the deaf in disasters: establishing the need for systematic training for state-level emergency management agencies and community organizations

    PubMed Central

    2013-01-01

    Background Deaf and hard-of-hearing (Deaf/HH) individuals have been underserved before and during emergencies. This paper will assess Deaf/HH related emergency preparedness training needs for state emergency management agencies and deaf-serving community-based organizations (CBOs). Methods Four approaches were used: 1) a literature review; 2) results from 50 key informant (KI) interviews from state and territorial-level emergency management and public health agencies; 3) results from 14 KI interviews with deaf-serving CBOs in the San Francisco Bay Area; and 4) a pilot program evaluation of an emergency responder training serving the Deaf/HH in one urban community. Results Results from literature review and state and territorial level KIs indicate that there is a substantive gap in emergency preparedness training on serving Deaf/HH provided by state agencies. In addition, local KI interviews with 14 deaf-serving CBOs found gaps in training within deaf-serving CBOs. These gaps have implications for preparing for and responding to all-hazards emergencies including weather-related or earthquake-related natural disasters, terrorist attacks, and nuclear-chemical disasters. Conclusion Emergency preparedness trainings specific to responding to or promoting preparedness of the Deaf/HH is rare, even for state agency personnel, and frequently lack standardization, evaluation, or institutionalization in emergency management infrastructure. This has significant policy and research implications. Similarly, CBOs are not adequately trained to serve the needs of their constituents. PMID:23497178

  11. Guidance for state attainment plans

    SciTech Connect

    Strait, R.

    1994-06-01

    Title I of the Clean Air act Amendments of 1990 significantly changed requirements for regulatory agencies to prepare state implementation plans that demonstrate attainment of the ozone National Ambient Air Quality Standards. State agencies now are required to submit plans that show how they will meet the standards by their attainment date. EPA has published a series of guidance documents to assist states in preparing their plans. In addition, the agency is developing software to assist states in projecting emissions and tracking reductions. This article summarizes the guidance documents and software program.

  12. Technical basis for establishing residual radioactive concentrations

    SciTech Connect

    Kennedy, W.E. Jr. ); Meck, R.A. )

    1991-02-01

    The US Nuclear Regulatory Commission (NRC) regulates the release of slightly radioactive property for unrestricted use. On July 3, 1990, the NRC published a Policy Statement concerning slightly radioactive materials that are below regulatory concern (BRC). The BRC Policy Statement establishes the framework within which the Commission will formulate rules or make licensing decisions to exempt from some or all regulatory controls certain practices involving small quantities of radioactive material.'' The heart of the NRC Policy Statement on BRC material is its individual and collective radiation dose limits. To ensure a uniform approach and consistent regulatory decisions, the NRC authorized the development of a comprehensive technical basis that considers the translation of residual contamination levels to annual dose. Radiation doses from residual contamination in buildings and soil are derived from a generic radiation exposure scenario analysis. This paper describes the development of the comprehensive technical basis for translating residual contamination levels to annual dose, provides the modeling details of an example scenario, and presents a comparison of results with existing guidance in Regulatory Guide 1.86. 4 refs., 1 fig., 2 tabs.

  13. Feeding bovine milks with low or high IgA levels is associated with altered re-establishment of murine intestinal microbiota after antibiotic treatment

    PubMed Central

    Young, Wayne; Cakebread, Julie A.; Haigh, Brendan J.

    2016-01-01

    Antibiotics are a vital and commonly used therapeutic tool, but their use also results in profound changes in the intestinal microbiota that can, in turn, have significant health consequences. Understanding how the microbiota recovers after antibiotic treatment will help to devise strategies for mitigating the adverse effects of antibiotics. Using a mouse model, we have characterized the changes occurring in the intestinal microbiota immediately after five days exposure to ampicillin, and then at three and fourteen days thereafter. During the fourteen day period of antibiotic recovery, groups of mice were fed either water, cows’ milk containing high levels of IgA, or cows’ milk containing low levels of IgA as their sole source of liquid. Effects on microbiota of feeding milks for 14 days were also assessed in groups of mice that had no ampicillin exposure. Changes in microbiota were measured by high throughput sequencing of the V4 to V6 variable regions of the 16S ribosomal RNA gene. As expected, exposure to ampicillin led to profound changes to the types and abundance of bacteria present, along with a loss of diversity. At 14 days following antibiotic exposure, mice fed water had recovered microbiota compositions similar to that prior to antibiotics. However, feeding High-IgA milk to mice that has been exposed to antibiotics was associated with altered microbiota compositions, including increased relative abundance of Lactobacillus and Barnesiella compared to the start of the study. Mice exposed to antibiotics then fed Low-IgA milk also showed increased Barnesiella at day 14. Mice without antibiotic perturbation, showed no change in their microbiota after 14 days of milk feeding. Overall, these findings add to a knowledge platform for optimizing intestinal function after treatment with antibiotics in the human population. PMID:27703861

  14. Systems Development in Guidance--a Learning-Task-Centered Approach. Final Report.

    ERIC Educational Resources Information Center

    Banathy, Bela H.; And Others

    To develop a systems-oriented model for guidance and counseling at all levels of schooling, a research project was conducted in a California school district, testing the applicability of systems concepts in guidance at the kindergarten and first grade levels. The project report includes a review of literature relating the systems approach to…

  15. Guidance for evidence-informed policies about health systems: rationale for and challenges of guidance development.

    PubMed

    Bosch-Capblanch, Xavier; Lavis, John N; Lewin, Simon; Atun, Rifat; Røttingen, John-Arne; Dröschel, Daniel; Beck, Lise; Abalos, Edgardo; El-Jardali, Fadi; Gilson, Lucy; Oliver, Sandy; Wyss, Kaspar; Tugwell, Peter; Kulier, Regina; Pang, Tikki; Haines, Andy

    2012-01-01

    In the first paper in a three-part series on health systems guidance, Xavier Bosch-Capblanch and colleagues examine how guidance is currently formulated in low- and middle-income countries, and the challenges to developing such guidance.

  16. Network Based Approach in the Establishment of the Relationship between Type 2 Diabetes Mellitus and Its Complications at the Molecular Level Coupled with Molecular Docking Mechanism

    PubMed Central

    Rampogu Lemuel, Mary

    2016-01-01

    Diabetes mellitus (DM) is one of the major metabolic disorders that is currently threatening the world. DM is seen associated with obesity and diabetic retinopathy (DR). In the present paper we tried to evaluate the relationship between the three aliments at the gene level and further performed the molecular docking to identify the common drug for all the three diseases. We have adopted several software programs such as Phenopedia, VennViewer, and CDOCKER to accomplish the objective. Our results revealed six genes that commonly associated and are involved in the signalling pathway. Furthermore, evaluation of common gene association from the selected set of genes projected the presence of SIRT1 in all the three aliments. Therefore, we targeted protein 4KXQ which was produced from the gene SIRT1 and challenged it with eight phytochemicals, adopting the CDOCKER. C1 compound has displayed highest -CDOCKER energy and -CDOCKER interaction energy of 43.6905 and 43.3953, respectively. Therefore, this compound is regarded as the most potential lead molecule.

  17. Network Based Approach in the Establishment of the Relationship between Type 2 Diabetes Mellitus and Its Complications at the Molecular Level Coupled with Molecular Docking Mechanism

    PubMed Central

    Rampogu Lemuel, Mary

    2016-01-01

    Diabetes mellitus (DM) is one of the major metabolic disorders that is currently threatening the world. DM is seen associated with obesity and diabetic retinopathy (DR). In the present paper we tried to evaluate the relationship between the three aliments at the gene level and further performed the molecular docking to identify the common drug for all the three diseases. We have adopted several software programs such as Phenopedia, VennViewer, and CDOCKER to accomplish the objective. Our results revealed six genes that commonly associated and are involved in the signalling pathway. Furthermore, evaluation of common gene association from the selected set of genes projected the presence of SIRT1 in all the three aliments. Therefore, we targeted protein 4KXQ which was produced from the gene SIRT1 and challenged it with eight phytochemicals, adopting the CDOCKER. C1 compound has displayed highest -CDOCKER energy and -CDOCKER interaction energy of 43.6905 and 43.3953, respectively. Therefore, this compound is regarded as the most potential lead molecule. PMID:27699170

  18. The Use of ICT in School Guidance: Attitudes and Practices of Guidance Counselors in Metro Manila, the Philippines

    ERIC Educational Resources Information Center

    Vinluan, Lorelei R.

    2011-01-01

    A survey was conducted among a sample of school guidance counselors in Metro Manila, the Philippines, to determine their level of awareness, attitudes, and extent of practice of ICT in the conduct of their work. The respondents showed a higher level of awareness of communication technologies than of information technologies. They spent an average…

  19. Abortion Information: A Guidance Viewpoint

    ERIC Educational Resources Information Center

    Wolleat, Patricia L.

    1975-01-01

    A number of questions relating to providing abortion information to teenagers can be raised from legal, ethical and philosophical standpoints. The purpose of this article is to examine abortion information-giving from the perspective of counseling and guidance theory and practice. (Author)

  20. THE STRESSOR IDENTIFICATION GUIDANCE DOCUMENT

    EPA Science Inventory

    THE STRESSOR IDENTIFICATION GUIDANCE DOCUMENT

    Susan M. Cormier, ORD/NRMRL, Susan B. Norton, ORD/NCEA, Glenn W. Suter, II ORD/NCEA, William Swietlik, OW lOST

    Science Question(s):

    MYP Science Question: How can multiple and possibly related causes of biological ...

  1. Axon guidance: FLRTing promotes attraction.

    PubMed

    Lowery, Laura Anne

    2014-03-01

    A recent study demonstrates a new mechanism by which crosstalk between multiple guidance cues is integrated during axon pathfinding. FLRT3 is a novel co-receptor for Robo1 that acts as a context-dependent modulator of Netrin-1 attraction in thalamocortical axons.

  2. Reading Guidance: Death and Grief.

    ERIC Educational Resources Information Center

    Smith, Alice Gullen

    1989-01-01

    Gives guidelines for the librarian using reading guidance (similar to bibliotherapy). Provides a nine-item annotated bibliography of novels for children and adolescents on the subject of death and grief. Appends an embryo list of categories suitable for content analysis of any file librarians might wish to keep on books suitable for use in this…

  3. Teacher Guidance of Knowledge Construction

    ERIC Educational Resources Information Center

    Schwarz, Baruch; Dreyfus, Tommy; Hadas, Nurit; Hershkowitz, Rina

    2004-01-01

    This paper focuses on how teachers guide construction of knowledge in classrooms. We suggest that guidance hinges on the kind of dialogue teachers choose to engage students in. We propose several classroom dialogue types relevant for the construction of knowledge and suggest that critical dialogue is particularly effective for knowledge…

  4. Developing Local Lifelong Guidance Strategies.

    ERIC Educational Resources Information Center

    Watts, A. G.; Hawthorn, Ruth; Hoffbrand, Jill; Jackson, Heather; Spurling, Andrea

    1997-01-01

    Outlines the background, rationale, methodology, and outcomes of developing local lifelong guidance strategies in four geographic areas. Analyzes the main components of the strategies developed and addresses a number of issues relating to the process of strategy development. Explores implications for parallel work in other localities. (RJM)

  5. Humanizing Education Through Guidance Counseling.

    ERIC Educational Resources Information Center

    Accola, W. V.

    A computerized information retrieval system has been designed to support the secondary school counseling effort. The system, entitled Total Guidance Information Support System (TGISS), runs on an IBM System/360 Model 65 facility and uses the IBM 2848 Display Control Unit. The software consists of an interactive communications program developed in…

  6. Quantitative Decision Support Requires Quantitative User Guidance

    NASA Astrophysics Data System (ADS)

    Smith, L. A.

    2009-12-01

    Is it conceivable that models run on 2007 computer hardware could provide robust and credible probabilistic information for decision support and user guidance at the ZIP code level for sub-daily meteorological events in 2060? In 2090? Retrospectively, how informative would output from today’s models have proven in 2003? or the 1930’s? Consultancies in the United Kingdom, including the Met Office, are offering services to “future-proof” their customers from climate change. How is a US or European based user or policy maker to determine the extent to which exciting new Bayesian methods are relevant here? or when a commercial supplier is vastly overselling the insights of today’s climate science? How are policy makers and academic economists to make the closely related decisions facing them? How can we communicate deep uncertainty in the future at small length-scales without undermining the firm foundation established by climate science regarding global trends? Three distinct aspects of the communication of the uses of climate model output targeting users and policy makers, as well as other specialist adaptation scientists, are discussed. First, a brief scientific evaluation of the length and time scales at which climate model output is likely to become uninformative is provided, including a note on the applicability the latest Bayesian methodology to current state-of-the-art general circulation models output. Second, a critical evaluation of the language often employed in communication of climate model output, a language which accurately states that models are “better”, have “improved” and now “include” and “simulate” relevant meteorological processed, without clearly identifying where the current information is thought to be uninformative and misleads, both for the current climate and as a function of the state of the (each) climate simulation. And thirdly, a general approach for evaluating the relevance of quantitative climate model output

  7. A guidance concept for hypersonic aerospacecrafts

    NASA Astrophysics Data System (ADS)

    Ishimoto, Shinji

    In this paper a guidance concept for hypersonic re-entry flights is presented. The method uses a closed-form guidance technique based on a drag acceleration reference profile. A guidance law for range control is developed. It employs a physical relation between vehicle energy and range instead of a prediction-correction technique used for Shuttle entry guidance. Simulation results show that the algorithm provides good performance.

  8. 48 CFR 225.7302 - Guidance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Guidance. 225.7302 Section 225.7302 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF... Guidance. For guidance on the role of the contracting officer in FMS programs that will require...

  9. Why Guidance Counseling Needs to Change

    ERIC Educational Resources Information Center

    Johnson, Jean; Rochkind, Jon; Ott, Amber

    2010-01-01

    Looking back on their high school experiences, young adults give the guidance counseling system "stunningly poor reviews," write the authors of this article. Using data from recent surveys of young people conducted by Public Agenda, the article describes a guidance system in which one-half of all students believe their guidance counselor sees them…

  10. Providing Career Guidance for Young Women.

    ERIC Educational Resources Information Center

    Colby, Pamela G.

    This module is directed at personnel working or planning to work in the areas of guidance, counseling, placement and follow-through in junior and senior high school settings, grades 7-12. The module topic is career guidance for young women of junior and senior high school age, aand the focus will be on providing nonbiased career guidance which…

  11. Quality Assurance in University Guidance Services

    ERIC Educational Resources Information Center

    Simon, Alexandra

    2014-01-01

    In Europe there is no common quality assurance framework for the delivery of guidance in higher education. Using a case study approach in four university career guidance services in England, France and Spain, this article aims to study how quality is implemented in university career guidance services in terms of strategy, standards and models,…

  12. 21 CFR 314.445 - Guidance documents.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... HUMAN USE APPLICATIONS FOR FDA APPROVAL TO MARKET A NEW DRUG Miscellaneous Provisions § 314.445 Guidance documents. (a) FDA has made available guidance documents under § 10.115 of this chapter to help you to...) maintains a list of guidance documents that apply to CDER's regulations. The list is maintained on...

  13. The Self in Guidance: Assumptions and Challenges.

    ERIC Educational Resources Information Center

    Edwards, Richard; Payne, John

    1997-01-01

    Examines the assumptions of "self" made in the professional and managerial discourses of guidance. Suggests that these assumptions obstruct the capacity of guidance workers to explain their own practices. Drawing on contemporary debates over identity, modernity, and postmodernity, argues for a more explicit debate about the self in guidance. (RJM)

  14. 78 FR 57450 - State Rail Plan Guidance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-18

    ... requirements for State rail plans. The State Rail Plan Guidance is available on FRA's Web site at http://www.fra.dot.gov/Page/P0511 . DATES: The final State Rail Plan Guidance is effective as of the publication....dot.gov/Page/P0511 . The purpose of FRA's final State Rail Plan Guidance is to describe the...

  15. Microfluidic control of axonal guidance

    NASA Astrophysics Data System (ADS)

    Gu, Ling; Black, Bryan; Ordonez, Simon; Mondal, Argha; Jain, Ankur; Mohanty, Samarendra

    2014-10-01

    The precision of axonal pathfinding and the accurate formation of functional neural circuitry are crucial for an organism during development as well as during adult central and peripheral nerve regeneration. While chemical cues are believed to be primarily responsible for axonal pathfinding, we hypothesize that forces due to localized fluid flow may directly affect neuronal guidance during early organ development. Here, we report direct evidence of fluid flow influencing axonal migration, producing turning angles of up to 90°. Microfluidic flow simulations indicate that an axon may experience significant bending force due to cross-flow, which may contribute to the observed axonal turning. This method of flow-based guidance was successfully used to fasciculate one advancing axon onto another, showcasing the potential of this technique to be used for the formation of in vitro neuronal circuits.

  16. Teleautonomous guidance for mobile robots

    NASA Technical Reports Server (NTRS)

    Borenstein, J.; Koren, Y.

    1990-01-01

    Teleautonomous guidance (TG), a technique for the remote guidance of fast mobile robots, has been developed and implemented. With TG, the mobile robot follows the general direction prescribed by an operator. However, if the robot encounters an obstacle, it autonomously avoids collision with that obstacle while trying to match the prescribed direction as closely as possible. This type of shared control is completely transparent and transfers control between teleoperation and autonomous obstacle avoidance gradually. TG allows the operator to steer vehicles and robots at high speeds and in cluttered environments, even without visual contact. TG is based on the virtual force field (VFF) method, which was developed earlier for autonomous obstacle avoidance. The VFF method is especially suited to the accommodation of inaccurate sensor data (such as that produced by ultrasonic sensors) and sensor fusion, and allows the mobile robot to travel quickly without stopping for obstacles.

  17. Guidance on future art commissioning.

    PubMed

    2009-05-01

    Delegates at Building Better Healthcare's recent "National Patient Environment and the Arts Conference 2009" in London heard how national public arts think tank ixia has appointed Bristol-based arts and wellbeing development agency Willis Newson to write "concise and convincing guidance" on commissioning art for new healthcare facilities. A key message, during a joint presentation, was that integrating artwork into hospitals and other healthcare premises requires the earliest possible consideration to reap the maximum rewards.

  18. Mars Science Laboratory Entry Guidance

    NASA Technical Reports Server (NTRS)

    Mendeck, Gavin F.

    2011-01-01

    The Mars Science Laboratory will be the first Mars mission to attempt a guided entry with the objective of safely delivering the entry vehicle to a survivable parachute deploy state within 12.5 km of the pre-designated parachute deploy coordinates. The Entry Terminal Point Controller guidance algorithm is derived from the final phase Apollo Command Module guidance and, like Apollo, modulates the bank angle to control range based on deviations in range, altitude rate, and drag acceleration from a reference trajectory. For application to Mars landers which must make use of the tenuous Martian atmosphere, it is critical to balance the lift of the vehicle to minimize the range while still ensuring a safe deploy altitude. An overview of the process to generate optimized guidance settings is presented, discussing improvements made over the last nine years. Performance tradeoffs between ellipse size and deploy altitude will be presented, along with imposed constraints of entry acceleration and heating. Performance sensitivities to the bank reversal deadbands, heading alignment, attitude initialization error, and entry delivery errors are presented.

  19. Standards, Guidance and Practices for Improved Data Quality

    SciTech Connect

    Martin B. Sattison

    2010-06-01

    Since the mid 1980s, the Idaho National Laboratory (INL) has been involved with numerous projects to collect operational reactor data, develop data tools, and trend and analyze that data for the U.S. Nuclear Regulatory Commission (NRC). Because the data are used in subsequent risk analyses, the NRC must have confidence in the quality of the data delivered. The NRC tasked the INL to establish a comprehensive data quality assurance program. A key element of that effort was to establish a set of requirements based on industry and government standards, guidance and good practices. This paper discusses where these were found, the process of extracting the requirements and recommendations from the source materials, and the consolidation of them into a concise set of 22 standards, guidance and practices for technical data quality. While this set was created specifically for the data programs within the NRC’s Office of Research, they have broad application to many high-technology industries.

  20. Career Guidance and Student Success in Dutch Higher Vocational Education

    ERIC Educational Resources Information Center

    te Wierik, Mark L. J.; Beishuizen, Jos; van Os, Willem

    2015-01-01

    To enhance student success, a growing number of vocational education and training institutions in the Netherlands are nowadays implementing new career guidance practices in their competence-based approaches to learning. Based on individual-level data of undergraduate first-year full-time students from a Dutch university of applied sciences, this…

  1. Competency-Based Career Guidance for the Classroom

    ERIC Educational Resources Information Center

    Sweeney, Thomas J.; Shafe, Marie C.

    1978-01-01

    Essential to a competency-based curriculum, according to the authors, are the concepts of career development, career choice, and career guidance in different subject areas and grade levels. They present a model delivery system of learning objectives and activities for various controllable and noncontrollable factors. (MF)

  2. Constructs of Work Used in Career Guidance. NICEC Briefing.

    ERIC Educational Resources Information Center

    Hirsh, Wendy; Kidd, Jenny; Watts, Tony

    The career guidance process uses a variety of frameworks and constructs to describe the world of work and to help individuals relate to it. As the world of work changes, these constructs require fundamental review. The constructs and frameworks currently used to describe work are of five types. Employment constructs describe occupation, level,…

  3. 21 CFR 10.115 - Good guidance practices.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Good guidance practices. 10.115 Section 10.115 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... office level or if you feel that you are not making progress by going through the chain of command,...

  4. 21 CFR 10.115 - Good guidance practices.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Good guidance practices. 10.115 Section 10.115 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... office level or if you feel that you are not making progress by going through the chain of command,...

  5. Training Information for Policy Guidance. R & D Monograph 76.

    ERIC Educational Resources Information Center

    Freedman, Marcia; Dutka, Anna

    Designed to help occupational analysts, employment and training operators, guidance counselors, and vocational educators to better assess the source, content, and level of training necessary to achieve the desired skill requirements for most occupations, this report contains an analysis of training patters for clusters of occupations, a case…

  6. Guidance Manual: Asbestos Operations & Maintenance Work Practices. Second Edition.

    ERIC Educational Resources Information Center

    National Inst. of Building Sciences, Washington, DC.

    This technical manual provides detailed guidance to building owners, asbestos program managers, and operations and maintenance (O&M) workers for managing asbestos-containing materials (ACM) in buildings. The manual addresses four different types of ACM found in buildings and three different levels of precaution which may be warranted by specific…

  7. A new guidance strategy for unpowered Space Shuttle orbiter flight

    NASA Technical Reports Server (NTRS)

    Elias, A.

    1974-01-01

    A new guidance strategy for use during the TAEM (terminal area energy management) phase of the Shuttle reentry flight has been developed. This guidance system steers the vehicle from initial conditions at about 70,000 ft altitude and Mach 1.5 to the beginning of the final landing maneuver. Explicit control of the vehicle's total energy (potential plus kinetic) via the energy dissipation rate allows this system to effectively control the vehicle's energy in the presence of a head or tail wind without a-priori knowledge of the wind. Furthermore, this is accomplished while maintaining a wings-level attitude during most of the flight.

  8. Unified State Plan for Guidance, Counseling and Placement in Colorado. Postsecondary.

    ERIC Educational Resources Information Center

    Carlson, Nancy; And Others

    This guide, one of three units in the Colorado state plan for guidance program development, is written for educators as both a guideline and a needs assessment instrument to assist in the identification of deficit areas in school guidance programs. In a beginning section, this unit for the postsecondary level provides a brief philosophy of…

  9. Ultrasound Imaging in Radiation Therapy: From Interfractional to Intrafractional Guidance.

    PubMed

    Western, Craig; Hristov, Dimitre; Schlosser, Jeffrey

    2015-06-01

    External beam radiation therapy (EBRT) is included in the treatment regimen of the majority of cancer patients. With the proliferation of hypofractionated radiotherapy treatment regimens, such as stereotactic body radiation therapy (SBRT), interfractional and intrafractional imaging technologies are becoming increasingly critical to ensure safe and effective treatment delivery. Ultrasound (US)-based image guidance systems offer real-time, markerless, volumetric imaging with excellent soft tissue contrast, overcoming the limitations of traditional X-ray or computed tomography (CT)-based guidance for abdominal and pelvic cancer sites, such as the liver and prostate. Interfractional US guidance systems have been commercially adopted for patient positioning but suffer from systematic positioning errors induced by probe pressure. More recently, several research groups have introduced concepts for intrafractional US guidance systems leveraging robotic probe placement technology and real-time soft tissue tracking software. This paper reviews various commercial and research-level US guidance systems used in radiation therapy, with an emphasis on hardware and software technologies that enable the deployment of US imaging within the radiotherapy environment and workflow. Previously unpublished material on tissue tracking systems and robotic probe manipulators under development by our group is also included.

  10. Ultrasound Imaging in Radiation Therapy: From Interfractional to Intrafractional Guidance

    PubMed Central

    Western, Craig; Hristov, Dimitre

    2015-01-01

    External beam radiation therapy (EBRT) is included in the treatment regimen of the majority of cancer patients. With the proliferation of hypofractionated radiotherapy treatment regimens, such as stereotactic body radiation therapy (SBRT), interfractional and intrafractional imaging technologies are becoming increasingly critical to ensure safe and effective treatment delivery. Ultrasound (US)-based image guidance systems offer real-time, markerless, volumetric imaging with excellent soft tissue contrast, overcoming the limitations of traditional X-ray or computed tomography (CT)-based guidance for abdominal and pelvic cancer sites, such as the liver and prostate. Interfractional US guidance systems have been commercially adopted for patient positioning but suffer from systematic positioning errors induced by probe pressure. More recently, several research groups have introduced concepts for intrafractional US guidance systems leveraging robotic probe placement technology and real-time soft tissue tracking software. This paper reviews various commercial and research-level US guidance systems used in radiation therapy, with an emphasis on hardware and software technologies that enable the deployment of US imaging within the radiotherapy environment and workflow. Previously unpublished material on tissue tracking systems and robotic probe manipulators under development by our group is also included. PMID:26180704

  11. 76 FR 43332 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ...; Class II Special Controls Guidance Document: Focused Ultrasound Stimulator System for Aesthetic Use... Guidance Document: Focused Ultrasound Stimulator System for Aesthetic Use.'' This guidance document... ``Class II Special Controls Guidance Document: Focused Ultrasound Stimulator System for Aesthetic Use''...

  12. Consolidated guidance about materials licenses: Program-specific guidance about portable gauge licenses. Final report; Volume 1

    SciTech Connect

    Vacca, P.C.; Whitten, J.E.; Pelchat, J.M.; Arredondo, S.A.; Matson, E.R.; Lewis, S.H.; Collins, D.J.; Santiago, P.A.; Tingle, W.

    1997-05-01

    As part of its redesign of the materials licensing process, NRC is consolidating and updating numerous guidance documents into a single comprehensive repository as described in NUREG-1539 and draft NUREG-1541. NUREG-1556, Vol. 1, is the first program-specific guidance developed for the new process and will serve as a template for subsequent program-specific guidance. This document is intended for use by applicants, licensees, and NRC staff and will also be available to Agreement States. This document supersedes the guidance previously found in draft Regulatory Guide DG-0008, ``Applications for the Use of Sealed Sources in Portable Gauging Devices,`` and in NMSs Policy and guidance Directive 2-07, ``Standard Review Plan for Applications for Use of Sealed Sources in Portable Gauging Devices.`` This final report takes a more risk-informed, performance-based approach to licensing portable gauges, and reduces the information(amount and level of detail) needed to support an application to use these devices. It incorporates many suggests submitted during the comment period on draft NUREG-1556, Volume 1. When published, this final report should be used in preparing portable gauge license applications. NRC staff will use this final report in reviewing these applications.

  13. Augmented Reality Image Guidance in Minimally Invasive Prostatectomy

    NASA Astrophysics Data System (ADS)

    Cohen, Daniel; Mayer, Erik; Chen, Dongbin; Anstee, Ann; Vale, Justin; Yang, Guang-Zhong; Darzi, Ara; Edwards, Philip'eddie'

    This paper presents our work aimed at providing augmented reality (AR) guidance of robot-assisted laparoscopic surgery (RALP) using the da Vinci system. There is a good clinical case for guidance due to the significant rate of complications and steep learning curve for this procedure. Patients who were due to undergo robotic prostatectomy for organ-confined prostate cancer underwent preoperative 3T MRI scans of the pelvis. These were segmented and reconstructed to form 3D images of pelvic anatomy. The reconstructed image was successfully overlaid onto screenshots of the recorded surgery post-procedure. Surgeons who perform minimally-invasive prostatectomy took part in a user-needs analysis to determine the potential benefits of an image guidance system after viewing the overlaid images. All surgeons stated that the development would be useful at key stages of the surgery and could help to improve the learning curve of the procedure and improve functional and oncological outcomes. Establishing the clinical need in this way is a vital early step in development of an AR guidance system. We have also identified relevant anatomy from preoperative MRI. Further work will be aimed at automated registration to account for tissue deformation during the procedure, using a combination of transrectal ultrasound and stereoendoscopic video.

  14. Enhanced Pseudo-Waypoint Guidance for Spacecraft Maneuvers

    NASA Technical Reports Server (NTRS)

    Carson, John; Acikmese, behcet

    2008-01-01

    An enhanced version of the scheme reported in "Pseudo-Waypoint Guidance for Proximity Spacecraft Maneuvers" (NPO-42753), NASA Tech Briefs, Vol. 31, No. 6 (June 2007), page 73 was developed. To recapitulate: the scheme provides algorithms for guidance and control (G&C) of a spacecraft maneuvering near a small astronomical body. The open-loop guidance problem is solved in advance or in real time by use of the pseudo-waypoint generation (PWG) method. Feedback control is implemented to track PWG trajectories, in a manner that enables updating of G&C in a model-predictive manner. The scheme includes silent periods following each thruster firing. The original version of the scheme provides for a fire-first, followed-by-silence sequence, which is disadvantageous in that the silence after final firing precludes reduction of any remaining velocity error -- an unacceptable result in the case of a maneuver for which a specific final velocity is required. In the enhanced version, the scheme is augmented with a fire-second technique, so that the final velocity can be established with a much higher precision because both the guidance and feedback firing can be performed and ceased at the final maneuver time.

  15. Haptic Shared Control in Tele-Manipulation: Effects of Inaccuracies in Guidance on Task Execution.

    PubMed

    van Oosterhout, Jeroen; Wildenbeest, Jeroen G W; Boessenkool, Henri; Heemskerk, Cock J M; de Baar, Marco R; van der Helm, Frans C T; Abbink, David A

    2015-01-01

    Haptic shared control is a promising approach to improve tele-manipulated task execution, by making safe and effective control actions tangible through guidance forces. In current research, these guidance forces are most often generated based on pre-generated, errorless models of the remote environment. Hence such guidance forces are exempt from the inaccuracies that can be expected in practical implementations. The goal of this research is to quantify the extent to which task execution is degraded by inaccuracies in the model on which haptic guidance forces are based. In a human-in-the-loop experiment, subjects (n = 14) performed a realistic tele-manipulated assembly task in a virtual environment. Operators were provided with various levels of haptic guidance, namely no haptic guidance (conventional tele-manipulation), haptic guidance without inaccuracies, and haptic guidance with translational inaccuracies (one large inaccuracy, in the order of magnitude of the task, and a second smaller inaccuracy). The quality of natural haptic feedback (i.e., haptic transparency) was varied between high and low to identify the operator's ability to detect and cope with inaccuracies in haptic guidance. The results indicate that haptic guidance is beneficial for task execution when no inaccuracies are present in the guidance. When inaccuracies are present, this may degrade task execution, depending on the magnitude and the direction of the inaccuracy. The effect of inaccuracies on overall task performance is dominated by effects found for the Constrained Translational Movement, due to its potential for jamming. No evidence was found that a higher quality of haptic transparency helps operators to detect and cope with inaccuracies in the haptic guidance.

  16. Flight Guidance System Requirements Specification

    NASA Technical Reports Server (NTRS)

    Miller, Steven P.; Tribble, Alan C.; Carlson, Timothy M.; Danielson, Eric J.

    2003-01-01

    This report describes a requirements specification written in the RSML-e language for the mode logic of a Flight Guidance System of a typical regional jet aircraft. This model was created as one of the first steps in a five-year project sponsored by the NASA Langley Research Center, Rockwell Collins Inc., and the Critical Systems Research Group of the University of Minnesota to develop new methods and tools to improve the safety of avionics designs. This model will be used to demonstrate the application of a variety of methods and techniques, including safety analysis of system and subsystem requirements, verification of key properties using theorem provers and model checkers, identification of potential sources mode confusion in system designs, partitioning of applications based on the criticality of system hazards, and autogeneration of avionics quality code. While this model is representative of the mode logic of a typical regional jet aircraft, it does not describe an actual or planned product. Several aspects of a full Flight Guidance System, such as recovery from failed sensors, have been omitted, and no claims are made regarding the accuracy or completeness of this specification.

  17. Family planning methods: new guidance.

    PubMed

    1996-10-01

    Presented in this report are the recommendations of two expert groups, the Technical Guidance/Competence Working Group of the US Agency for International Development's Maximizing Access and Quality Initiative and the World Health Organization's Family Planning and Population Unit, regarding currently available family planning methods. The former group addressed key biomedical questions and formulated recommendations about 11 groups of family planning methods: combined oral contraceptives, progestin-only pills during breast feeding, progestin-only injectables, combined injectable contraceptives, Norplant implants, copper-bearing IUDs, tubal occlusion, vasectomy, lactational amenorrhea method, natural family planning, and barrier methods. A table presents the relative importance, by method, of procedures such as pelvic exam, blood pressure reading, breast exam, and screening for sexually transmitted diseases and cervical cancer. The medical eligibility recommendations for each method are also presented in tabular form, with four categories for temporary methods: 1) no restrictions on use, 2) advantages generally outweigh theoretical or proven risks, 3) theoretical or proven risks usually outweigh the advantages, and 4) unacceptable health risks. Included among the 41 conditions for which eligibility criteria are specified are age, smoking, thromboembolic disorder, headaches, irregular vaginal bleeding, family history of breast cancer, obesity, drug interactions, parity, breast feeding, postpartum, and postabortion. The new guidance presented in this report enables providers to give family planning clients expanded contraceptive choices while ensuring method safety and effectiveness. PMID:9342775

  18. Guidance assistance, autonomous guidance and assisted distance guidance in precision agriculture

    NASA Astrophysics Data System (ADS)

    Gomez Gil, Jaime

    The present doctoral thesis analyses the potential of technological advances in electronics, telematics and communications for their application in agriculture. Research has been carried out and some prototypes have been developed in four stages: In a first phase, it has been carried out the analysis and development of guidance assistance devices. It has been carried out the development of a microcontroller based device which has been patented by the author of this thesis and later, has been developed and commercialized by the company GMV Sistemas. In a second phase, it has been developed a module of distance guidance which allows the remote driving of an agricultural tractor. There have been made the mechanical modifications in a tractor and the necessary hardware has been installed in order to allow the remote control of the tractor steering. The laptop receives the guidance instructions by means of wireless communication from the computer installed in the base. In a third phase, there have been developed two autonomous guidance systems, one by means of GPS and the other by means of Computer Vision, using as base the platform developed in the previous phase. It is incorporated a module of path generation from the plot outline. With this trajectory, the tractor is able to do most of the farming work in a plot without the participation of the driver. The last phase has been developed at the same time than the previous ones and it is located in Precision Agriculture. In this phase it has been carried out the performance of a centrifugal spreader of fertilizer and it has been developed an application for the generation in a precise way of fertilizer maps. The carried out studies have produced real developments implanted on the machinery of the author's farm. The development of the work has been carried out on a software platform with modules which are intercommunicated between them, because a large part of the developed applications have a common base of work. This

  19. Faculty of Prehospital Care, Royal College of Surgeons Edinburgh guidance for medical provision for wilderness medicine.

    PubMed

    Mellor, Adrian; Dodds, Naomi; Joshi, Raj; Hall, John; Dhillon, Sundeep; Hollis, Sarah; Davis, Pete; Hillebrandt, David; Howard, Eva; Wilkes, Matthew; Langdana, Burjor; Lee, David; Hinson, Nigel; Williams, Thomas Harcourt; Rowles, Joe; Pynn, Harvey

    2015-01-01

    To support leaders and those involved in providing medical care on expeditions in wilderness environments, the Faculty of Pre-Hospital Care (FPHC) of The Royal College of Surgeons of Edinburgh convened an expert panel of leading healthcare professionals and expedition providers. The aims of this panel were to: (1) provide guidance to ensure the best possible medical care for patients within the geographical, logistical and human factor constraints of an expedition environment. (2) Give aspiring and established expedition medics a 'benchmark' of skills they should meet. (3) Facilitate expedition organisers in selecting the most appropriate medical cover and provider for their planned activity. A system of medical planning is suggested to enable expedition leaders to identify the potential medical risks and their mitigation. It was recognised that the scope of practice for wilderness medicine covers elements of primary healthcare, pre-hospital emergency medicine and preventative medicine. Some unique competencies were also identified. Further to this, the panel recommends the use of a matrix and advisory expedition medic competencies relating to the remoteness and medical threat of the expedition. This advice is aimed at all levels of expedition medic, leader and organiser who may be responsible for delivering or managing the delivery of remote medical care for participants. The expedition medic should be someone equipped with the appropriate medical competencies, scope of practice and capabilities in the expedition environment and need not necessarily be a qualified doctor. In addition to providing guidance regarding the clinical competencies required of the expedition medic, the document provides generic guidance and signposting to the more pertinent aspects of the role of expedition medic.

  20. Faculty of Prehospital Care, Royal College of Surgeons Edinburgh guidance for medical provision for wilderness medicine.

    PubMed

    Mellor, Adrian; Dodds, Naomi; Joshi, Raj; Hall, John; Dhillon, Sundeep; Hollis, Sarah; Davis, Pete; Hillebrandt, David; Howard, Eva; Wilkes, Matthew; Langdana, Burjor; Lee, David; Hinson, Nigel; Williams, Thomas Harcourt; Rowles, Joe; Pynn, Harvey

    2015-01-01

    To support leaders and those involved in providing medical care on expeditions in wilderness environments, the Faculty of Pre-Hospital Care (FPHC) of The Royal College of Surgeons of Edinburgh convened an expert panel of leading healthcare professionals and expedition providers. The aims of this panel were to: (1) provide guidance to ensure the best possible medical care for patients within the geographical, logistical and human factor constraints of an expedition environment. (2) Give aspiring and established expedition medics a 'benchmark' of skills they should meet. (3) Facilitate expedition organisers in selecting the most appropriate medical cover and provider for their planned activity. A system of medical planning is suggested to enable expedition leaders to identify the potential medical risks and their mitigation. It was recognised that the scope of practice for wilderness medicine covers elements of primary healthcare, pre-hospital emergency medicine and preventative medicine. Some unique competencies were also identified. Further to this, the panel recommends the use of a matrix and advisory expedition medic competencies relating to the remoteness and medical threat of the expedition. This advice is aimed at all levels of expedition medic, leader and organiser who may be responsible for delivering or managing the delivery of remote medical care for participants. The expedition medic should be someone equipped with the appropriate medical competencies, scope of practice and capabilities in the expedition environment and need not necessarily be a qualified doctor. In addition to providing guidance regarding the clinical competencies required of the expedition medic, the document provides generic guidance and signposting to the more pertinent aspects of the role of expedition medic. PMID:26629337

  1. Epinephrine Policies and Protocols Guidance for Schools: Equipping School Nurses to Save Lives.

    PubMed

    Tanner, Andrea; Clarke, Carrie

    2016-01-01

    In response to limited direction given by legislative bodies to school nurses about how to implement state-mandated or recommended stock epinephrine programs in their schools, NASN convened a workgroup of invested stakeholders. This workgroup was challenged to equip school nurses with the necessary tools to develop policies and protocols regarding stock epinephrine in their school districts. The dynamic workgroup subcommittees focused on policies, procedures, and reporting tools. This article reviews the results of the subcommittees' work and the overall collaboration within the workgroup. This article provides clear, nationally recognized guidance on the best practice for establishing stock epinephrine policies and protocols with reporting tools at the local school district level. PMID:26739930

  2. Virtual Ultrasound Guidance for Inexperienced Operators

    NASA Technical Reports Server (NTRS)

    Caine, Timothy; Martin, Davis

    2012-01-01

    Medical ultrasound or echocardiographic studies are highly operator-dependent and generally require lengthy training and internship to perfect. To obtain quality echocardiographic images in remote environments, such as on-orbit, remote guidance of studies has been employed. This technique involves minimal training for the user, coupled with remote guidance from an expert. When real-time communication or expert guidance is not available, a more autonomous system of guiding an inexperienced operator through an ultrasound study is needed. One example would be missions beyond low Earth orbit, in which the time delay inherent with communication will make remote guidance impractical.

  3. NASP guidance design for vehicle autonomy

    NASA Astrophysics Data System (ADS)

    Wagner, E. A.; Li, I.; Nguyen, D. D.; Nguyen, P. L.

    1990-10-01

    Vehicle guidance for General Dynamics' NASP vehicle is planned to be self-contained onboard the vehicle, and independent of any ground support during the mission. It will include real-time onboard abort and ascent trajectory optimization capability. Although these features should be considered a natural outgrowth of research in guidance and trajectory optimization and advances in computation, facilitating full vehicle autonomy for NASP represents a significant advance relative to any flight-demonstrated guidance. Algorithms and processing requirements for autonomous NASP vehicle guidance are considered.

  4. Stochastically optimized monocular vision-based navigation and guidance

    NASA Astrophysics Data System (ADS)

    Watanabe, Yoko

    The objective of this thesis is to design a relative navigation and guidance law for unmanned aerial vehicles, or UAVs, for vision-based control applications. The autonomous operation of UAVs has progressively developed in recent years. In particular, vision-based navigation, guidance and control has been one of the most focused on research topics for the automation of UAVs. This is because in nature, birds and insects use vision as the exclusive sensor for object detection and navigation. Furthermore, it is efficient to use a vision sensor since it is compact, light-weight and low cost. Therefore, this thesis studies the monocular vision-based navigation and guidance of UAVs. Since 2-D vision-based measurements are nonlinear with respect to the 3-D relative states, an extended Kalman filter (EKF) is applied in the navigation system design. The EKF-based navigation system is integrated with a real-time image processing algorithm and is tested in simulations and flight tests. The first closed-loop vision-based formation flight between two UAVs has been achieved, and the results are shown in this thesis to verify the estimation performance of the EKF. In addition, vision-based 3-D terrain recovery was performed in simulations to present a navigation design which has the capability of estimating states of multiple objects. In this problem, the statistical z-test is applied to solve the correspondence problem of relating measurements and estimation states. As a practical example of vision-based control applications for UAVs, a vision-based obstacle avoidance problem is specially addressed in this thesis. A navigation and guidance system is designed for a UAV to achieve a mission of waypoint tracking while avoiding unforeseen stationary obstacles by using vision information. An EKF is applied to estimate each obstacles' position from the vision-based information. A collision criteria is established by using a collision-cone approach and a time-to-go criterion. A minimum

  5. A Self-Adaptive Missile Guidance System for Statistical Inputs

    NASA Technical Reports Server (NTRS)

    Peery, H. Rodney

    1960-01-01

    A method of designing a self-adaptive missile guidance system is presented. The system inputs are assumed to be known in a statistical sense only. Newton's modified Wiener theory is utilized in the design of the system and to establish the performance criterion. The missile is assumed to be a beam rider, to have a g limiter, and to operate over a flight envelope where the open-loop gain varies by a factor of 20. It is shown that the percent of time that missile acceleration limiting occurs can be used effectively to adjust the coefficients of the Wiener filter. The result is a guidance system which adapts itself to a changing environment and gives essentially optimum filtering and minimum miss distance.

  6. Navigation and guidance requirements for commercial VTOL operations

    NASA Technical Reports Server (NTRS)

    Hoffman, W. C.; Hollister, W. M.; Howell, J. D.

    1974-01-01

    The NASA Langley Research Center (LaRC) has undertaken a research program to develop the navigation, guidance, control, and flight management technology base needed by Government and industry in establishing systems design concepts and operating procedures for VTOL short-haul transportation systems in the 1980s time period. The VALT (VTOL Automatic Landing Technology) Program encompasses the investigation of operating systems and piloting techniques associated with VTOL operations under all-weather conditions from downtown vertiports; the definition of terminal air traffic and airspace requirements; and the development of avionics including navigation, guidance, controls, and displays for automated takeoff, cruise, and landing operations. The program includes requirements analyses, design studies, systems development, ground simulation, and flight validation efforts.

  7. Factors Impacting the Successful Implementation of Comprehensive Guidance and Counseling Programs in Nova Scotia.

    ERIC Educational Resources Information Center

    Lehr, Ron; Sumarah, John

    2002-01-01

    Assesses factors that contribute to the successful implementation of comprehensive guidance and counseling programs at the elementary, junior, and senior high school levels in Nova Scotia. Examines counselors' perceptions of what helps or hinders successful implementation. (Contains 15 references.) (GCP)

  8. D & D screening risk evaluation guidance

    SciTech Connect

    Robers, S.K.; Golden, K.M.; Wollert, D.A.

    1995-09-01

    The Screening Risk Evaluation (SRE) guidance document is a set of guidelines provided for the uniform implementation of SREs performed on decontamination and decommissioning (D&D) facilities. Although this method has been developed for D&D facilities, it can be used for transition (EM-60) facilities as well. The SRE guidance produces screening risk scores reflecting levels of risk through the use of risk ranking indices. Five types of possible risk are calculated from the SRE: current releases, worker exposures, future releases, physical hazards, and criticality. The Current Release Index (CRI) calculates the current risk to human health and the environment, exterior to the building, from ongoing or probable releases within a one-year time period. The Worker Exposure Index (WEI) calculates the current risk to workers, occupants and visitors inside contaminated D&D facilities due to contaminant exposure. The Future Release Index (FRI) calculates the hypothetical risk of future releases of contaminants, after one year, to human health and the environment. The Physical Hazards Index (PHI) calculates the risks to human health due to factors other than that of contaminants. Criticality is approached as a modifying factor to the entire SRE, due to the fact that criticality issues are strictly regulated under DOE. Screening risk results will be tabulated in matrix form, and Total Risk will be calculated (weighted equation) to produce a score on which to base early action recommendations. Other recommendations from the screening risk scores will be made based either on individual index scores or from reweighted Total Risk calculations. All recommendations based on the SRE will be made based on a combination of screening risk scores, decision drivers, and other considerations, as determined on a project-by-project basis.

  9. Regulatory guidance on soil cover systems

    SciTech Connect

    Kane, J.D.

    1991-12-31

    The US Nuclear Regulatory Commission (NRC) in September 1991, completed revisions to 14 sections of the Standard Review Plan (SRP) for the Review of a License Application for a Low-Level Radioactive Waste Disposal Facility. The major purposes of the SRP are to ensure the quality and uniformity of the NRC staff`s safety reviews, and to present a well-defined base from which to evaluate the acceptability of information and data provided in the Safety Analysis Report (SAR) portion of the license application. SRP 3.2, entitled, Design Considerations for Normal and Abnormal/Accident Conditions, was one of the sections that was revised by the NRC staff. This revision was completed to provide additional regulatory guidance on the important considerations that need to be addressed for the proper design and construction of soil cover systems that are to be placed over the LLW. The cover system over the waste is acknowledged to be one of the most important engineered barriers for the long-term stable performance of the disposal facility. The guidance in revised SRP 3.2 summarizes the previous efforts and recommendations of the US Army Corps of Engineers (COE), and a peer review panel on the placement of soil cover systems. NRC published these efforts in NUREG/CR-5432. The discussions in this paper highlight selected recommendations on soil cover issues that the NRC staff considers important for ensuring the safe, long-term performance of the soil cover systems. The development phases to be discussed include: (1) cover design; (2) cover material selection; (3) laboratory and field testing; (4) field placement control and acceptance; and (5) penetrations through the constructed covers.

  10. Can coffee improve image guidance?

    NASA Astrophysics Data System (ADS)

    Wirz, Raul; Lathrop, Ray A.; Godage, Isuru S.; Burgner-Kahrs, Jessica; Russell, Paul T.; Webster, Robert J.

    2015-03-01

    Anecdotally, surgeons sometimes observe large errors when using image guidance in endonasal surgery. We hypothesize that one contributing factor is the possibility that operating room personnel might accidentally bump the optically tracked rigid body attached to the patient after registration has been performed. In this paper we explore the registration error at the skull base that can be induced by simulated bumping of the rigid body, and find that large errors can occur when simulated bumps are applied to the rigid body. To address this, we propose a new fixation method for the rigid body based on granular jamming (i.e. using particles like ground coffee). Our results show that our granular jamming fixation prototype reduces registration error by 28%-68% (depending on bump direction) in comparison to a standard Brainlab reference headband.

  11. Longwall Guidance and Control Development

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The longwall guidance and control (G&C) system was evaluated to determine which systems and subsystems lent themselves to automatic control in the mining of coal. The upper coal/shale interface was identified as the reference for a vertical G&C system, with two sensors (the natural backgound and the sensitized pick) being used to locate and track this boundary. In order to insure a relatively smooth recession surface (roof and floor of the excavated seam), a last and present cut measuring instrument (acoustic sensor) was used. Potentiometers were used to measure elevations of the shearer arms. The intergration of these components comprised the vertical control system (pitch control). Yaw and roll control were incorporated into a face alignment system which was designed to keep the coal face normal to its external boundaries. Numerous tests, in the laboratory and in the field, have confirmed the feasibility of automatic horizon control, as well as determining the face alignment.

  12. Guidance, Navigation, and Control Program

    NASA Technical Reports Server (NTRS)

    Hinkel, Heather; Tamblyn, Scott; Jackson, William L.; Foster, Chris; Brazzel, Jack; Manning, Thomas R.; Clark, Fred; Spehar, Pete; Barrett, Jim D.; Milenkovic, Zoran

    2011-01-01

    The Rendezvous and Proximity Operations Program (RPOP) is real-time guidance, navigation, and control (GN&C) domain piloting-aid software that provides 3D Orbiter graphics and runs on the Space Shuttle's Criticality-3 Payload and General Support Computer (PGSC) in the crew cockpit. This software provides the crew with Situational Awareness during the rendezvous and proximity operations phases of flight. RPOP can be configured from flight to flight, accounting for mission-specific flight scenarios and target vehicles, via initialization load (I-load) data files. The software provides real-time, automated, closed-loop guidance recommendations and the capability to integrate the crew s manual backup techniques. The software can bring all relative navigation sensor data, including the Orbiter's GPC (general purpose computer) data, into one central application to provide comprehensive situational awareness of the rendezvous and proximity operations trajectory. RPOP also can separately maintain trajectory estimates (past, current, and predicted) based on certain data types and co-plot them, in order to show how the various navigation solutions compare. RPOP s best estimate of the relative trajectory is determined by a relative Kalman filter processing data provided by the sensor suite s most accurate sensor, the trajectory control sensor (TCS). Integrated with the Kalman filter is an algorithm that identifies the reflector that the TCS is tracking. Because RPOP runs on PC laptop computers, the development and certification lifecycles are more agile, flexible, and cheaper than those that govern the Orbiter FSW (flight software) that runs in the GPC. New releases of RPOP can be turned around on a 3- to 6-month template, from new Change Request (CR) to certification, depending on the complexity of the changes.

  13. 78 FR 56752 - Interim Staff Guidance Specific Environmental Guidance for Integral Pressurized Water Reactors...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... comment on, draft Interim Staff Guidance (ISG) ESP/COL-ISG-027, ``Interim Staff Guidance Specific..., early site permits (ESPs), and combined licenses (COLs). DATES: Submit comments by October 15, 2013... issues ESP/COL-ISGs to facilitate timely implementation of current staff guidance and to...

  14. Publication of OIG compliance program guidance for clinical laboratories--HHS. Notice.

    PubMed

    1998-08-24

    This Federal Register notice sets forth the OIG's recently-issued Compliance Program Guidance for Clinical Laboratories. The OIG had previously developed and published a model compliance plan for the clinical laboratory industry on March 3, 1997. This Compliance Program Guidance for Clinical Laboratories is intended to be more consistent with compliance program guidances issued by the OIG with respect to the hospital industry and to home health agencies, and serves to clarify various aspects of the original model plan. As with previously-issued compliance program guidances, we believe that the development of this guidance for clinical laboratories will continue as a positive step towards promoting a higher level of ethical and lawful conduct throughout the entire health care community.

  15. Supervisory guidance and behavioral integrity: relationships with employee citizenship and deviant behavior.

    PubMed

    Dineen, Brian R; Lewicki, Roy J; Tomlinson, Edward C

    2006-05-01

    The authors examined the effects of supervisory guidance (providing instruction to employees) and behavioral integrity (a pattern of word-deed alignment) on employee organizational citizenship behavior (OCB) and deviant behavior. Results revealed a pattern of Supervisory Guidance x Behavioral Integrity interaction effects, such that relationships between guidance and outcome variables were dependent on the level of behavioral integrity exhibited by supervisors. The interactions suggest a positive relationship between supervisory guidance and OCBs when behavioral integrity is high but also a positive relationship between guidance and deviant behavior when behavioral integrity is low. These results were consistent across 2 independent field samples: 1 assessing individual employee perceptions of supervisory behavior and the other assessing aggregate perceptions of supervisory behavior among employees in bank branches.

  16. Heterogeneity in European research integrity guidance: relying on values or norms?

    PubMed

    Godecharle, Simon; Nemery, Benoit; Dierickx, Kris

    2014-07-01

    Similar forms of misconduct are perceived differently throughout Europe. There are no extensive surveys on the guidance on research integrity in the different countries of Europe. Therefore, we performed a systematic content analysis of (biomedical) research integrity guidance documents from all the countries of the European Economic Area. We show that there is strong heterogeneity concerning research integrity guidance on crucial aspects, for example, the defining of research misconduct, at both an international and a national level. We also sought to explain why the guidance documents differ by distinguishing the approaches that underlie them. We distinguished a value-based and a norm-based approach, as well as different perspectives on trust. The current confusing situation concerning research integrity guidance hampers international research and possibly wastes research funds. We risk talking past each other, if we do not take the distinction between these underlying approaches into account.

  17. Apollo 13 Guidance, Navigation, and Control Challenges

    NASA Technical Reports Server (NTRS)

    Goodman, John L.

    2009-01-01

    Combustion and rupture of a liquid oxygen tank during the Apollo 13 mission provides lessons and insights for future spacecraft designers and operations personnel who may never, during their careers, have participated in saving a vehicle and crew during a spacecraft emergency. Guidance, Navigation, and Control (GNC) challenges were the reestablishment of attitude control after the oxygen tank incident, re-establishment of a free return trajectory, resolution of a ground tracking conflict between the LM and the Saturn V S-IVB stage, Inertial Measurement Unit (IMU) alignments, maneuvering to burn attitudes, attitude control during burns, and performing manual GNC tasks with most vehicle systems powered down. Debris illuminated by the Sun and gaseous venting from the Service Module (SM) complicated crew attempts to identify stars and prevented execution of nominal IMU alignment procedures. Sightings on the Sun, Moon, and Earth were used instead. Near continuous communications with Mission Control enabled the crew to quickly perform time critical procedures. Overcoming these challenges required the modification of existing contingency procedures.

  18. Hands-Free System for Bronchoscopy Planning and Guidance.

    PubMed

    Khare, Rahul; Bascom, Rebecca; Higgins, William E

    2015-12-01

    Bronchoscopy is a commonly used minimally invasive procedure for lung-cancer staging. In standard practice, however, physicians differ greatly in their levels of performance. To address this concern, image-guided intervention (IGI) systems have been devised to improve procedure success. Current IGI bronchoscopy systems based on virtual bronchoscopic navigation (VBN), however, require involvement from the attending technician. This lessens physician control and hinders the overall acceptance of such systems. We propose a hands-free VBN system for planning and guiding bronchoscopy. The system introduces two major contributions. First, it incorporates a new procedure-planning method that automatically computes airway navigation plans conforming to the physician's bronchoscopy training and manual dexterity. Second, it incorporates a guidance strategy for bronchoscope navigation that enables user-friendly system control via a foot switch, coupled with a novel position-verification mechanism. Phantom studies verified that the system enables smooth operation under physician control, while also enabling faster navigation than an existing technician-assisted VBN system. In a clinical human study, we noted a 97% bronchoscopy navigation success rate, in line with existing VBN systems, and a mean guidance time per diagnostic site = 52 s. This represents a guidance time often nearly 3 min faster per diagnostic site than guidance times reported for other technician-assisted VBN systems. Finally, an ergonomic study further asserts the system's acceptability to the physician and long-term potential.

  19. Effects of expertise and auditory guidance on traditional dance performance.

    PubMed

    Sofianidis, George; Hatzitaki, Vassilia; McKinley, Patricia

    2012-01-01

    This study investigated how the dancer's level of expertise and the type of auditory guidance provided influence the kinematic profile of the lower limbs during traditional dance performance. Ten experts in traditional Greek dance (age: 25±3.29 years, five males and five females) and eleven novice participants (age: 26.45±3.88 years, six males and five females), all Greek natives, performed a series of Greek and Irish dance steps with auditory guidance of the metrics (verbal counting) and the music of the respective dances. An electromagnetic tracking system sampled (at 100 Hz) the angular displacement of the two lower legs about the Mediolateral axis during dance performance. Segment rotations were analyzed in the time and frequency domain. Expert dancers displayed significantly lower variability of lower leg rotation and stronger interlimb coupling when compared to novice performers. In novice performers, the power of the lower limb angular displacement extended to higher frequencies when dance performance was guided by music compared to metrical guidance. The addition of music and the origin of the dance interfered with performance for novices but not experienced dancers. Kinematic analysis of the lower limbs may open a new window for the investigation of learning and auditory guidance effects on dance performance.

  20. Simulation evaluation of a speed-guidance law for Harrier approach transitions

    NASA Technical Reports Server (NTRS)

    Merrick, Vernon K.; Moralez, Ernesto; Stortz, Michael W.; Hardy, Gordon H.; Gerdes, Ronald M.

    1991-01-01

    An exponential-deceleration speed guidance law is formulated which mimics the technique currently used by Harrier pilots to perform decelerating approaches to a hover. This guidance law was tested along with an existing two-step constant deceleration speed guidance law, using a fixed-base piloted simulator programmed to represent a YAV-8B Harrier. Decelerating approaches to a hover at a predetermined station-keeping point were performed along a straight (-3 deg glideslope) path in headwinds up to 40 knots and turbulence up to 6 ft./sec. Visibility was fixed at one-quarter nautical mile and 100 ft. cloud ceiling. Three Harrier pilots participated in the experiment. Handling qualities with the aircraft equipped with the standard YAV-8B rate damped attitude stability augmentation system were adequate (level 2) using either speed guidance law. However, the exponential deceleration speed guidance law was rated superior to the constant-deceleration speed guidance law by a Cooper-Harper handling qualities rating of about one unit independent of the level of wind and turbulence. Replacing the attitude control system of the YAV-8B with a high fidelity model following attitude flight controller increased the approach accuracy and reduced the pilot workload. With one minor exception, the handling qualities for the approach were rated satisfactory (level 1). It is concluded that the exponential deceleration speed guidance law is the most cost effective.

  1. IRS offers guidance on physician practice valuation.

    PubMed

    Curry, R W

    1996-07-01

    Many healthcare organizations are acquiring physician practices in response to competitive pressures. But little guidance has been available in regard to issues such as private inurement and payment for referral charges. The Internal Revenue Service, however, has recently issued detailed guidance concerning such issues.

  2. Optimal nonlinear guidance for a reentry vehicle

    NASA Astrophysics Data System (ADS)

    Harel, D.; Guelman, M.

    Using the exact nonlinear equations of motion an optimal guidance law for a reentry vehicle to achieve at impact a zero miss and a predefined flight path angle is derived. The application of the optimal guidance law in feedback form is based on the on-line solution of a nonlinear algebraic equation. Numerical results are presented.

  3. Guidance in Adult and Continuing Education.

    ERIC Educational Resources Information Center

    McNamara, Gerry

    The provision of guidance in adult and continuing education in Ireland was examined. First, policy in Ireland regarding guidance for adults in education is discussed in the context of the proposals adopted by the European Union (EU) Commission and EU Member States pursuant to the EU Year of Lifelong Learning in 1996. Recent literature on career…

  4. Consultant Directory for Rural Career Guidance.

    ERIC Educational Resources Information Center

    Donaldson, Kloyd N.; Edington, Everett D.

    The National Rural Career Guidance Project for Rural and Small Schools was designed to promote active exchange of information among rural schools and to provide services to administrators, counselors, and teachers wishing to implement or upgrade career guidance activities in their schools. The directory was developed for the purpose of providing…

  5. RATIONALE FOR ELEMENTARY SCHOOL GUIDANCE. FINAL REPORT.

    ERIC Educational Resources Information Center

    COTTINGHAM, HAROLD F.

    AN IDENTIFICATION OF THE CONCEPTUAL ELEMENTS LEADING TO A RATIONALE FOR THE GUIDANCE FUNCTION IN THE ELEMENTARY SCHOOL WAS INVESTIGATED, UTILIZING THE RESULTS OF RESEARCH AND GUIDANCE EXPERIENCE, AND PHILOSOPHICAL, PSYCHOLOGICAL, AND EDUCATIONAL CONCEPTS. THE SPECIFIC OBJECTIVES INCLUDED THE PREPARATION OF A TENTATIVE POSITION STATEMENT OR WORKING…

  6. Guidance in Rural Schools. Yearbook. February 1942.

    ERIC Educational Resources Information Center

    Dunn, Fannie W., Ed.

    This book is a 1942 compilation of solicited information on rural education trends and guidance programs in the United States. Chapter 1 emphasizes the necessity of good educational guidance for rural children and discusses factors which determine child development, including the rural environment and standards of living. Chapter 2 discusses…

  7. 75 FR 76079 - Sound Incentive Compensation Guidance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... Office of Thrift Supervision Sound Incentive Compensation Guidance AGENCY: Office of Thrift Supervision... collection. Title of Proposal: Sound Incentive Compensation Guidance. OMB Number: 1550-0129. Form Number: N/A... compensation arrangements at a financial institution do not encourage employees to take excessive risks....

  8. 75 FR 22679 - Sound Incentive Compensation Guidance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... Office of Thrift Supervision Sound Incentive Compensation Guidance AGENCY: Office of Thrift Supervision... collection. Title of Proposal: Sound Incentive Compensation Guidance. OMB Number: 1550-0NEW. Form Number: N/A... compensation arrangements at a financial institution do not encourage employees to take excessive risks....

  9. 75 FR 53023 - Sound Incentive Compensation Guidance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... Office of Thrift Supervision Sound Incentive Compensation Guidance AGENCY: Office of Thrift Supervision... collection. Title of Proposal: Sound Incentive Compensation Guidance. OMB Number: 1550-0129. Form Number: N/A... compensation arrangements at a financial institution do not encourage employees to take excessive risks....

  10. Guidance trajectories for aeroassisted orbital transfer

    NASA Technical Reports Server (NTRS)

    Miele, A.

    1990-01-01

    Research on aerobraking guidance schemes is presented. The intent is to produce aerobraking guidance trajectories exhibiting many of the desirable characteristics of optimal aerobraking trajectories. Both one-control schemes and two-control schemes are studied. The research is in the interest of aeroassisted flight experiment vehicles (AFE) and aeroassisted orbital transfer (AOT) vehicles.

  11. 21 CFR 312.145 - Guidance documents.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HUMAN USE INVESTIGATIONAL NEW DRUG APPLICATION Miscellaneous § 312.145 Guidance documents. (a) FDA has... of Drug Information, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Guidance documents. 312.145 Section 312.145...

  12. Foundations for Policy in Guidance and Counseling.

    ERIC Educational Resources Information Center

    Herr, Edwin L., Ed.; Pinson, Nancy M., Ed.

    This book provides educators, counselors, policy makers, and community members with information about the state of the art of federal and state policy in guidance and counseling. The two chapters in part 1, Overview, are: "Foundations for Policy in Guidance and Counseling: An Introduction", by Edwin L. Herr and Nancy M. Pinson; and "A Counselor…

  13. The Internationalization of Educational and Vocational Guidance

    ERIC Educational Resources Information Center

    Savickas, Mark L.; Van Esbroeck, Raoul; Herr, Edwin L.

    2005-01-01

    The authors identify and discuss the main themes from the discourse on the internationalization of educational and vocational guidance at the 2004 "Symposium on International Perspectives on Career Development," co sponsored by the International Association for Educational and Vocational Guidance and the National Career Development Association.…

  14. Gifted Child Development and Guidance Study.

    ERIC Educational Resources Information Center

    Virginia Beach City Public Schools, VA.

    The Gifted Child Development and Guidance Program of Virginia Beach City (Virginia) Public Schools was developed to interest gifted college-bound students in a vocational class in child development and guidance that might lead to further career interest in child-related professions. This report briefly describes program promotion; student…

  15. Guidance Counsellor Strategies for Handling Bullying

    ERIC Educational Resources Information Center

    Power-Elliott, Michleen; Harris, Gregory E.

    2012-01-01

    The purpose of this exploratory-descriptive study was to examine how guidance counsellors in the province of Newfoundland and Labrador would handle a specific verbal-relational bullying incident. Also of interest was guidance counsellor involvement and training in bullying programmes and Positive Behaviour Supports. Data for this study was…

  16. Educational Guidance: New Responses for Inner Cities.

    ERIC Educational Resources Information Center

    Further Education Unit, London (England).

    This document summarizes a project which attempted to develop and evaluate the provision of educational guidance for unemployed adults, especially those from ethnic minority groups in inner city areas in the United Kingdom. This report: (1) outlines the background of the project; (2) indicates key features of the shop-front guidance unit that was…

  17. Vocational Guidance Requests within the International Scene

    ERIC Educational Resources Information Center

    Goodman, Jane; Gillis, Sarah

    2009-01-01

    This article summarizes the work of a diverse group of researchers and practitioners from 5 continents on "Vocational Guidance Requests Within the International Scene" presented in the discussion group at a symposium of the International Association for Educational and Vocational Guidance, the Society for Vocational Psychology, and the National…

  18. Approach guidance for outer planet pioneer missions

    NASA Technical Reports Server (NTRS)

    Bejczy, A. K.

    1975-01-01

    Onboard optical approach guidance measurements for spin-stabilized Pioneer-type spacecraft are discussed. Approach guidance measurement accuracy requirements are outlined. The application concept and operation principle of the V-slit star tracker are discussed within the context of approach guidance measurements and measurables. It is shown that the accuracy of onboard optical approach guidance measurements is inherently coupled to the stability characteristics of the spacecraft spin axis. Geometrical and physical measurement parameters are presented for Pioneer entry probe missions to Uranus via Jupiter or Saturn flyby. The impact of these parameters on both sensor instrumentation and measurement system design is discussed. The need for sensing extended objects is shown. The feasibility of implementing an onboard approach guidance measurement system for Pioneer-type spacecraft is indicated. Two Pioneer 10 onboard measurement experiments performed in May-June 1974 are described.

  19. Improving rehabilitation exercise performance through visual guidance.

    PubMed

    Lam, Agnes W K; HajYasien, Ahmed; Kulic, Dana

    2014-01-01

    In current physical rehabilitation protocols, patients typically perform exercises without feedback or guidance following the initial demonstrations from the physiotherapist. This paper proposes a system providing continuous visual feedback and guidance to patients to improve quality of motion performance and adherence to instructions. The system consists of body-worn inertial measurement units which continuously measure the patient's pose. The measured pose is overlaid with the instructed motion on a visual display shown to the user during exercise performance. Two user studies were conducted with healthy participants to evaluate the usability of the visual guidance tool. Motion data was collected by the inertial measurement sensors and used to evaluate quality of motion, comparing user performance with and without visual feedback and with or without exercise guidance. The quantitative and qualitative results of the studies confirm that performing the exercises with the visual guidance tool promotes more consistent exercise performance and proper technique. PMID:25570311

  20. Indiana Secondary Vocational Guidance Planning Handbook. Field Test Edition.

    ERIC Educational Resources Information Center

    Phelps, Joyce E.

    This secondary vocational guidance planning handbook is designed for secondary school personnel who want (1) to start a vocational guidance program, (2) to assess their vocational guidance services, (3) to expand or diversify their vocational guidance services, (4) to gather ideas for new vocational guidance activities. The first of three major…

  1. Guidance for Environmental Mangement Science and Technology Roadmapping

    SciTech Connect

    Dixon, Brent Wayne

    2001-02-01

    Science and technology roadmapping is a planning process to help identify technical capabilities needed for both project- and program-level cleanup efforts, map them into technology alternatives, and develop plans to ensure that the required scientific knowledge and tools will be available when needed. Application of science and technology roadmapping within Invironmental Management (EM) requires significant flexibility to accommodate the variations between different projects and programs and the different levels of roadmapping application. The author has provided direct support to EM’s Office of Science and Technology (OST) in the development of draft guidance for science and technology roadmapping in EM. This paper provides a summary of this guidance and a synopsis of lessons learned from the application of roadmapping to a number of EM projects and programs.

  2. Entry Guidance for the Reusable Launch Vehicle

    NASA Technical Reports Server (NTRS)

    Lu, Ping

    1999-01-01

    The X-33 Advanced Technology Demonstrator is a half-scale prototype developed to test the key technologies needed for a full-scale single-stage reusable launch vehicle (RLV). The X-33 is a suborbital vehicle that will be launched vertically, and land horizontally. The goals of this research were to develop an alternate entry guidance scheme for the X-33 in parallel to the actual X-33 entry guidance algorithms, provide comparative and complementary study, and identify potential new ways to improve entry guidance performance. Toward these goals, the nominal entry trajectory is defined by a piecewise linear drag-acceleration-versus-energy profile, which is in turn obtained by the solution of a semi-analytical parameter optimization problem. The closed-loop guidance is accomplished by tracking the nominal drag profile with primarily bank-angle modulation on-board. The bank-angle is commanded by a single full-envelope nonlinear trajectory control law. Near the end of the entry flight, the guidance logic is switched to heading control in order to meet strict conditions at the terminal area energy management interface. Two methods, one on ground-track control and the other on heading control, were proposed and examined for this phase of entry guidance where lateral control is emphasized. Trajectory dispersion studies were performed to evaluate the effectiveness of the entry guidance algorithms against a number of uncertainties including those in propulsion system, atmospheric properties, winds, aerodynamics, and propellant loading. Finally, a new trajectory-regulation method is introduced at the end as a promising precision entry guidance method. The guidance principle is very different and preliminary application in X-33 entry guidance simulation showed high precision that is difficult to achieve by existing methods.

  3. Space Telescope Fine Guidance Sensor Bearing Anomaly

    NASA Technical Reports Server (NTRS)

    Loewenthal, S.; Esper, J.; Pan, J.; Decker, J.

    1996-01-01

    Early in 1993, a servo motor within one of three Fine Guidance Sensors (FGS) aboard the Hubble Space Telescope (HST) reached stall torque levels on several occasions. Little time was left to plan replacement during the first servicing mission, scheduled at the end of '93. Accelerated bearing life tests confirmed that a small angle rocking motion, known as Coarse Track (CT), accelerated bearing degradation. Saturation torque levels were reached after approximately 20 million test cycles, similar to the flight bearings. Reduction in CT operation, implemented in flight software, extended FGS life well beyond the first servicing mission. However in recent years, bearing torques have resumed upward trends and together with a second, recent bearing torque anomaly has necessitated a scheduled FGS replacement during the upcoming second servicing mission in '97. The results from two series of life tests to quantify FGS bearing remaining life, discussion of bearing on-orbit performance, and future plans to service the FGS servos are presented in this paper.

  4. Space shuttle guidance, navigation, and control design equations. Volume 3: Guidance

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Space shuttle guidance, navigation, and control design equations are presented. The space-shuttle mission includes three relatively distinct guidance phases which are discussed; atmospheric boost, which is characterized by an adaptive guidance law; extra-atmospheric activities; and re-entry activities, where aerodynamic surfaces are the principal effectors. Guidance tasks include pre-maneuver targeting and powered flight guidance, where powered flight is defined to include the application of aerodynamic forces as well as thruster forces. A flow chart which follows guidance activities throughout the mission from the pre-launch phase through touchdown is presented. The main guidance programs and subroutines used in each phase of a typical rendezvous mission are listed. Detailed software requirements are also presented.

  5. [Disclosing the diagnosis and guidance].

    PubMed

    Bopp-Kistler, Irene

    2015-04-01

    Before the disclosure of the diagnosis, both the patients with dementia and their relatives experience a long time not only full of insecurity, uncertainty, fear and misgivings but also of conflicts. The beginning of a neurodegenerative disease is always associated with a lot of open questions. If young patients are still active in their professional life, already the stage of "Mild Cognitive Impairment" will cause mistakes, burnout, mobbing, depression and sick leaves. In the partner relationship conflicts and accusations may emerge. It is far too little recognized that those problems at the relational level are often more burdening than the typical deficiencies due to dementia. Unfortunately, it is still considered that a clarification and diagnosis are only worthwhile for diseases which are curable. However, the aim of every evidence-based medicine should be giving every patient and his relatives the best possible quality of life, including symptomatic treatment options and prevention of possible complications. A frank opening discussion of the diagnosis paves the way for the patient and his relatives to deal with the situation and to develop together a solution strategy in the challenging setting of dementia, which always affects the whole familial and social system. The patient is entitled to be informed about his/her diagnosis, including dementia. The diagnostic disclosure requires time and highest professionalism, the knowledge of the individual deficiencies and resources, the social situation, the biography and the personality of the patients but also of their relatives. The diagnostic disclosure arouses a lot of emotions, that need to be addressed and also be absorbed. Primarily, the conversation should be conducted with the patient, but preferably in the presence of the relatives. A very important point is the appreciation of the dementia patient, even with anosognosia. The relatives should not be given just general advice, there should rather be a

  6. 76 FR 63676 - Final Division of Safety Systems Interim Staff Guidance DSS-ISG-2010-01: Staff Guidance Regarding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... COMMISSION Final Division of Safety Systems Interim Staff Guidance DSS-ISG- 2010-01: Staff Guidance Regarding... final Division of Safety Systems Interim Staff Guidance, (DSS-ISG) DSS- ISG-2010-01, ``Staff Guidance... guidance to the NRC staff reviewer to address the increased complexity of recent spent fuel pool...

  7. Axon Guidance in the Auditory System: Multiple Functions of Eph Receptors

    PubMed Central

    Cramer, Karina S.; Gabriele, Mark L.

    2014-01-01

    The neural pathways of the auditory system underlie our ability to detect sounds and to transform amplitude and frequency information into rich and meaningful perception. While it shares some organizational features with other sensory systems, the auditory system has some unique functions that impose special demands on precision in circuit assembly. In particular, the cochlear epithelium creates a frequency map rather than a space map, and specialized pathways extract information on interaural time and intensity differences to permit sound source localization. The assembly of auditory circuitry requires the coordinated function of multiple molecular cues. Eph receptors and their ephrin ligands constitute a large family of axon guidance molecules with developmentally regulated expression throughout the auditory system. Functional studies of Eph/ephrin signaling have revealed important roles at multiple levels of the auditory pathway, from the cochlea to the auditory cortex. These proteins provide graded cues used in establishing tonotopically ordered connections between auditory areas, as well as discrete cues that enable axons to form connections with appropriate postsynaptic partners within a target area. Throughout the auditory system, Eph proteins help to establish patterning in neural pathways during early development. This early targeting, which is further refined with neuronal activity, establishes the precision needed for auditory perception. PMID:25010398

  8. Numerical Skip-Entry Guidance

    NASA Technical Reports Server (NTRS)

    Tigges, Michael; Crull, Timothy; Rea, Jeremy; Johnson, Wyatt

    2006-01-01

    This paper assesses a preliminary guidance and targeting strategy for accomplishing Skip-Entry (SE) flight during a lunar return-capsule entry flight. One of the primary benefits of flying a SE trajectory is to provide the crew with continuous Continental United States (CONUS) landing site access throughout the lunar month. Without a SE capability, the capsule must land either in water or at one of several distributed land sites in the Southern Hemisphere for a significant portion of a lunar month using a landing and recovery scenario similar to that employed during the Apollo program. With a SE trajectory, the capsule can land either in water at a site in proximity to CONUS or at one of several distributed landing sites within CONUS, thereby simplifying the operational requirements for crew retrieval and vehicle recovery, and possibly enabling a high degree of vehicle reusability. Note that a SE capability does not require that the vehicle land on land. A SE capability enables a longer-range flight than a direct-entry flight, which permits the vehicle to land at a much greater distance from the Entry Interface (EI) point. This does not exclude using this approach to push the landing point to a water location in proximity of CONUS and utilizing water or airborne recovery forces.

  9. Low Gravity Guidance System for Airborne Microgravity Research

    NASA Technical Reports Server (NTRS)

    Rieke, W. J.; Emery, E. F.; Boyer, E. O.; Hegedus, C.; ODonoghue, D. P.

    1996-01-01

    Microgravity research techniques have been established to achieve a greater understanding of the role of gravity in the fundamentals of a variety of physical phenomena and material processing. One technique in use at the NASA Lewis Research Center involves flying Keplarian trajectories with a modified Lear Jet and DC-9 aircraft to achieve a highly accurate Microgravity environment by neutralizing accelerations in all three axis of the aircraft. The Low Gravity Guidance System (LGGS) assists the pilot and copilot in flying the trajectories by displaying the aircraft acceleration data in a graphical display format. The Low Gravity Guidance System is a microprocessor based system that acquires and displays the aircraft acceleration information. This information is presented using an electroluminescent display mounted over the pilot's instrument panel. The pilot can select the Microgravity range that is required for a given research event. This paper describes the characteristics, design, calibration and testing of the Low Gravity Guidance System Phase 3, significant lessons from earlier systems and the developmental work on future systems.

  10. 78 FR 54949 - Major Project Financial Plan Guidance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-06

    ... TRANSPORTATION Federal Highway Administration Major Project Financial Plan Guidance AGENCY: Federal Highway... Major Project Financial Plan Guidance outlining the procedures the FHWA will follow when reviewing and approving Financial Plans. The proposed Major Project Financial Plan Guidance incorporates changes...

  11. The Development of Vocational Guidance in the USSR.

    ERIC Educational Resources Information Center

    Kostin, L. A.

    1986-01-01

    The author defines the scope and importance of vocational guidance in the Soviet Union. He states that such guidance is primarily for youth. He discusses the institutional framework of vocational guidance programs and new developments in the Soviet Union. (CH)

  12. Molecular mechanisms of optic axon guidance

    NASA Astrophysics Data System (ADS)

    Inatani, Masaru

    2005-12-01

    Axon guidance is one of the critical processes during vertebrate central nervous system (CNS) development. The optic nerve, which contains the axons of retinal ganglion cells, has been used as a powerful model to elucidate some of the mechanisms underlying axon guidance because it is easily manipulated experimentally, and its function is well understood. Recent molecular biology studies have revealed that numerous guidance molecules control the development of the visual pathway. This review introduces the molecular mechanisms involved in each critical step during optic axon guidance. Axonal projections to the optic disc are thought to depend on adhesion molecules and inhibitory extracellular matrices such as chondroitin sulfate. The formation of the head of the optic nerve and the optic chiasm require ligand-receptor interactions between netrin-1 and the deleted in colorectal cancer receptor, and Slit proteins and Robo receptors, respectively. The gradient distributions of ephrin ligands and Eph receptors are essential for correct ipsilateral projections at the optic chiasm and the topographic mapping of axons in the superior colliculus/optic tectum. The precise gradient is regulated by transcription factors determining the retinal dorso-ventral and nasal-temporal polarities. Moreover, the axon guidance activities by Slit and semaphorin 5A require the existence of heparan sulfate, which binds to numerous guidance molecules. Recent discoveries about the molecular mechanisms underlying optic nerve guidance will facilitate progress in CNS developmental biology and axon-regeneration therapy.

  13. Optimal guidance law in quantum mechanics

    SciTech Connect

    Yang, Ciann-Dong Cheng, Lieh-Lieh

    2013-11-15

    Following de Broglie’s idea of a pilot wave, this paper treats quantum mechanics as a problem of stochastic optimal guidance law design. The guidance scenario considered in the quantum world is that an electron is the flight vehicle to be guided and its accompanying pilot wave is the guidance law to be designed so as to guide the electron to a random target driven by the Wiener process, while minimizing a cost-to-go function. After solving the stochastic optimal guidance problem by differential dynamic programming, we point out that the optimal pilot wave guiding the particle’s motion is just the wavefunction Ψ(t,x), a solution to the Schrödinger equation; meanwhile, the closed-loop guidance system forms a complex state–space dynamics for Ψ(t,x), from which quantum operators emerge naturally. Quantum trajectories under the action of the optimal guidance law are solved and their statistical distribution is shown to coincide with the prediction of the probability density function Ψ{sup ∗}Ψ. -- Highlights: •Treating quantum mechanics as a pursuit-evasion game. •Reveal an interesting analogy between guided flight motion and guided quantum motion. •Solve optimal quantum guidance problem by dynamic programming. •Gives a formal proof of de Broglie–Bohm’s idea of a pilot wave. •The optimal pilot wave is shown to be a wavefunction solved from Schrödinger equation.

  14. Human Systems Integration: Unmanned Aircraft Control Station Certification Plan Guidance

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This document provides guidance to the FAA on important human factors considerations that can be used to support the certification of a UAS Aircraft Control Station (ACS). This document provides a synopsis of the human factors analysis, design and test activities to be performed to provide a basis for FAA certification. The data from these analyses, design activities, and tests, along with data from certification/qualification tests of other key components should be used to establish the ACS certification basis. It is expected that this information will be useful to manufacturers in developing the ACS Certification Plan,, and in supporting the design of their ACS.

  15. Coastal nonpoint pollution control program: Program development and approval guidance

    SciTech Connect

    Not Available

    1993-01-01

    The document, developed by NOAA and EPA, contains guidance for states in developing and implementing their coastal nonpoint pollutant source programs. It describes the requirements that must be met, including: the geographic scope of the program; the pollutant sources to be addressed; the types of management measures used; the establishment of critical areas; technical assistance, public participation, and administrative coordination; and, the process for program submission and Federal approval. The document also contains the criteria by which NOAA and EPA will review the states' submissions.

  16. ICDF Complex Waste Profile and Verification Sample Guidance

    SciTech Connect

    W. M. Heileson

    2006-10-01

    This guidance document will assist waste generators who characterize waste streams destined for disposal at the Idaho Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Disposal Facility (ICDF) Complex. The purpose of this document is to develop a conservative but appropriate way to (1) characterize waste for entry into the ICDF; (2) ensure compliance with the waste acceptance criteria; and (3) facilitate disposal at the ICDF landfill or evaporation pond. In addition, this document will establish the waste verification process used by ICDF personnel to ensure that untreated waste meets applicable ICDF acceptance limits

  17. A guidance and control assessment of three vertical landing options for RLV

    NASA Astrophysics Data System (ADS)

    Gallaher, M.; Coughlin, D.; Krupp, D.

    1995-09-01

    The National Aeronautics and Space Administration is considering a vertical lander as a candidate concept for a single-stage-to-orbit reusable launch vehicle (RLV). Three strategies for guiding and controlling the inversion of a reentering RLV from a nose-first attitude to a vertical landing attitude are suggested. Each option is simulated from a common reentry state to touchdown, using a common guidance algorithm and different controllers. Results demonstrate the characteristics that typify and distinguish each concept and help to identify peculiar problems, level of guidance and control sophistication required, feasibility concerns, and areas in which stringent subsystem requirements will be imposed by guidance and control.

  18. A guidance and control assessment of three vertical landing options for RLV

    NASA Technical Reports Server (NTRS)

    Gallaher, M.; Coughlin, D.; Krupp, D

    1995-01-01

    The National Aeronautics and Space Administration is considering a vertical lander as a candidate concept for a single-stage-to-orbit reusable launch vehicle (RLV). Three strategies for guiding and controlling the inversion of a reentering RLV from a nose-first attitude to a vertical landing attitude are suggested. Each option is simulated from a common reentry state to touchdown, using a common guidance algorithm and different controllers. Results demonstrate the characteristics that typify and distinguish each concept and help to identify peculiar problems, level of guidance and control sophistication required, feasibility concerns, and areas in which stringent subsystem requirements will be imposed by guidance and control.

  19. Navigating through 'a labyrinth' of guidance.

    PubMed

    Pearson, Susan

    2014-09-01

    Devising a strategy to deliver safe water to thousands of outlets spread across numerous buildings is always going to be a challenge, so how do you navigate your way through a bewildering labyrinth of sometimes contradictory guidance documents? Is there, in fact, simply too much guidance? Posing this question at a recent one-day conference on waterborne infections in healthcare facilities, Paul Nolan, authorised water engineer (AE), and operations manager for PFI provider, Lend Lease, took delegates through a review of the latest guidance and regulations, as Susan Pearson reports. PMID:25282983

  20. A Community Frost/Freeze Susceptibility Operational Guidance Tool

    NASA Astrophysics Data System (ADS)

    Hall, B. L.; Curtis, A.; Timlin, M.; Woloszyn, M.; Zaloudek, Z.; Hilberg, S.; Guinan, P.; Andresen, J.; Longstroth, M.; Wolf, R.; Shanklin, R.; Spoden, P.

    2013-12-01

    In response to historical costly and damaging freeze events in the north-central United States, the Midwestern Regional Climate Center (MRCC) has teamed up with the National Weather Service (NWS), State Climatologists, and land grant university Extension agricultural and horticultural specialists to develop an operational online guidance tool to help monitor, assess, and mitigate these extreme weather phenomena. The Vegetation Impact Program (VIP), hosted by the MRCC, was established in spring 2013 to provide a partnership opportunity among these stakeholders of vegetation and climate monitoring and assessment. It offers an online portal to operational assessment tools, a means of communicating status of vegetative growth and climate conditions in the region, and multiple methods of communicating between sectors and stakeholders. The Frost/Freeze Project is the first impact monitoring project within VIP and was inspired by NWS forecasters requesting help attaining decision-making assistance and guidance tools both within the NWS community and the community of vegetation experts. Early accomplishments have included: (1) the development of daily, operational climate monitoring maps based upon in situ atmospheric observations from the cooperative network (Co-op), (2) development of online guidance and impact reporting forms for VIP subscribers to submit their observations from both the field and forecasting offices, and (3) an email listserv for the VIP community to share general information. Future plans include expanding the spatial domain of the project to the 48 states, incorporating hourly observations from both national and local/state mesonets, and integrating digital forecast data real-time to provide vegetation susceptibility and risk guidance tools.

  1. 76 FR 44594 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance Document: Repetitive Transcranial Magnetic Stimulation Systems... Document: Repetitive Transcranial Magnetic Stimulation Systems.'' This guidance document describes a...

  2. Diagnosis Levels in Vocational Guidance and Placement Processes

    ERIC Educational Resources Information Center

    Donoso, Trinidad; Figuera, Maria Pilar

    2007-01-01

    Career and employment counseling has been shown to be a key tool for assisting in processes of socio-professional placement. The objective of this article is to offer an innovative model of intervention that addresses the three vertices of labour market, social fabric and personal context, from which one can understand and globally analyze those…

  3. The Guidance Clinic - An Alternative to Suspension

    ERIC Educational Resources Information Center

    Stiavelli, Richard E.; Sykes, Dudley E.

    1972-01-01

    A guidance clinic program for disruptive students, based on behavior modification theory and positive reinforcement, has proven effective in dealing with junior and senior high school students who ordinarily would be suspended or excluded from school. (AN)

  4. Delta launch vehicle inertial guidance system (DIGS)

    NASA Technical Reports Server (NTRS)

    Duck, K. I.

    1973-01-01

    The Delta inertial guidance system, part of the Delta launch vehicle improvement effort, has been flown on three launches and was found to perform as expected for a variety of mission profiles and vehicle configurations.

  5. 78 FR 15710 - Strong Sensitizer Guidance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... From the Federal Register Online via the Government Publishing Office CONSUMER PRODUCT SAFETY COMMISSION Strong Sensitizer Guidance AGENCY: Consumer Product Safety Commission. ACTION: Notice of availability. SUMMARY: The U.S. Consumer Product Safety Commission (CPSC or Commission) is announcing...

  6. 21 CFR 316.50 - Guidance documents.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... USE ORPHAN DRUGS Availability of Information § 316.50 Guidance documents. FDA's Office of Orphan... Federal Register. A request for a copy of the list should be directed to the Office of Orphan...

  7. A discussion of higher order software concepts as they apply to functional requirements and specifications. [space shuttles and guidance

    NASA Technical Reports Server (NTRS)

    Hamilton, M.

    1973-01-01

    The entry guidance software functional requirements (requirements design phase), its architectural requirements (specifications design phase), and the entry guidance software verified code are discussed. It was found that the proper integration of designs at both the requirements and specifications levels are of high priority consideration.

  8. Maternal Knowledge and Behaviors regarding Discipline: The Effectiveness of a Hands-On Education Program in Positive Guidance

    ERIC Educational Resources Information Center

    Saunders, Rachel; McFarland-Piazza, Laura; Jacobvitz, Deborah; Hazen-Swann, Nancy; Burton, Rosalinda

    2013-01-01

    This study examined which method is most effective in supporting parents to use positive guidance techniques, a lecture-based only parent training series or a lecture-based plus hands-on parent training series. Maternal characteristics of depression, stress level, and attitudes towards positive guidance were explored as possible moderators. In…

  9. 77 FR 35986 - Guidance for Industry on Toll-Free Number Labeling and Related Requirements for Over-the-Counter...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ... certain OTC drugs. FDA is issuing this small entity compliance guide as level 2 guidance consistent with... HUMAN SERVICES Food and Drug Administration Guidance for Industry on Toll-Free Number Labeling and Related Requirements for Over-the-Counter and Prescription Drugs Marketed With Approved...

  10. DOE performance indicators guidance document

    SciTech Connect

    Not Available

    1992-12-01

    SEN-29-91 directed that a Department-wide uniform process for trending and analysis of operational data be established for DOE facilities. This Performance Indicator (PI) Program establishes a uniform system for trending and analyzing operational data providing an important tool to help assess and support progress in improving performance and strengthening both DOE and contractor line management control of operations. DOE, similar to the commercial nuclear industry, considers that facilities with good performance, as measured by an overall set of performance indicators, are well-managed facilities. The Performance Indicator Program established by SEN-29-91 is but one of several initiatives undertaken by DOE to instill a new DOE and DOE contractor line management culture committed to achieving a rising standard of acceptable performance. Line management trending and analysis of data depicting the performance of their facilities is an essential element in creating this culture of ``continuous improvement,`` where performance gains achieved are maintained and early identification of deteriorating environmental, safety, and health conditions is accomplished.

  11. The Protestant Establishment Revisited

    ERIC Educational Resources Information Center

    Baltzell, E. Digby

    1976-01-01

    The author's book, "The Protestant Establishment: Aristocracy and Caste in America", is highly critical of the WASP (White-Anglo-Saxon-Protestant) establishment and proposed the development and need for some sort of upper-class ruling-group. Here is a re-evaluation of his book, now thirteen years old, by the author. (Author/RK)

  12. 75 FR 29350 - Draft Guidance for Industry: Questions and Answers Regarding the Reportable Food Registry as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-25

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry: Questions and Answers Regarding the Reportable Food Registry as Established by the Food and Drug Administration Amendments Act of 2007... information to the industry in complying with the Reportable Food Registry requirements prescribed by the...

  13. 10 CFR Appendix A to Part 719 - Guidance for Legal Resource Management

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... variety of considerations and circumstances. 48 CFR 31.201-3 establishes that no presumption of... Costs While 10 CFR part 719 provides procedures associated with incurring and monitoring legal costs... 10 Energy 4 2014-01-01 2014-01-01 false Guidance for Legal Resource Management A Appendix A...

  14. 77 FR 59929 - Guidance for Industry on Acute Bacterial Exacerbations of Chronic Bronchitis in Patients With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... regarding the overall development program and clinical trial designs for drugs to support an indication for... Innovation Act of 2012 that FDA review guidances for the conduct of clinical trials with respect to... for clinical trial sponsors entitled ``Establishment and Operation of Clinical Trial Data...

  15. 77 FR 11133 - Draft Guidance for Industry on Complicated Urinary Tract Infections: Developing Drugs for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ... clinical trial designs to support approval of drugs. DATES: Although you can comment on any guidance at any... trial sponsors ``Establishment and Operation of Clinical Trial Data Monitoring Committees'' have been... margin based on historical observational data compared to the results of previously conducted...

  16. 78 FR 13073 - Interim Guidance for Revised Implementation of the International Convention for the Prevention of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ... Revised MARPOL Annex V Implementation.'' On July 15, 2011, the International Maritime Organization's (IMO... SECURITY Coast Guard Interim Guidance for Revised Implementation of the International Convention for the... International Convention for the Prevention of Pollution from Ships (MARPOL) Annex V, by establishing a...

  17. GUIDANCE FOR OBTAINING REPRESENTATIVE ANALYTICAL LABORATORY SUBSAMPLES FROM PARTICULATE LABORATORY SAMPLES

    EPA Science Inventory

    An ongoing research program has been established to experimentally verify the application of the Gy theory to environmental samples, which serves as a supporting basis for -the material presented in this guidance. Research results from studies performed by the United
    States E...

  18. Meyer Bloomfield: Organizer of the Vocational Guidance Movement (1907-1917)

    ERIC Educational Resources Information Center

    Savickas, Mark L.

    2009-01-01

    Meyer Bloomfield was the preeminent leader of the vocational guidance movement during the first 20 years of the 20th century. From 1907 to 1917, he worked to establish organizations, which today are called the National Career Development Association and the American Management Association, and to found a journal, which is now called the "Journal…

  19. Initial Experimental Airworthiness Certification Guidance for UAS. UAS Experimental Certification Process and Guidance

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This paper addresses the regulatory processes and requirements already in place by which an applicant might obtain experimental airworthiness certification for a civil Unmanned Aircraft System (UAS). It is more extensive and subsequent to an earlier, similar deliverable, PD007, which was an interim study of the same topic. Since few regulatory airworthiness and operating standards exist for UAS like those for traditional manned aircraft and since most UAS have historically been developed and operated under military auspices, civil use of UAS in the NAS is a new and unfamiliar challenge requiring specific and unique considerations. Experimental certification is the most basic level of FAA approval toward routine UAS operation in the NAS. The paper reviews and explains existing FAA requirements for an applicant seeking experimental airworthiness approval and details the process for submission of necessary information. It summarizes the limited purposes for which experimental aircraft may be used and addresses pertinent aspects of UAS design, construction and operation in the NAS in harmony with traditional manned aircraft. Policy IPT position is that UAS, while different from manned aircraft, can use the same initial processes to gain civil operating experience under the experimental approval. Particular note is taken of those UAS-unique characteristics which require extra attention to assure equivalent safety of operation, such as the UAS control station and sense-and-avoid. The paper also provides "best practices" guidance for UAS manufacturers and FAA personnel in two appendices. The material in Appendix A is intended to provide guidance on assuring UAS safety to FAA, and provides FAA personnel with a suggested list of items to review, with a focus on UAS unique factors, prior to issuance of an experimental airworthiness certificate. Appendix B provides an outline for a program letter which a manufacturer could use in preparing the application for an UAS

  20. Some data processing requirements for precision Nap-Of-the-Earth (NOE) guidance and control of rotorcraft

    NASA Technical Reports Server (NTRS)

    Clement, Warren F.; Mcruer, Duane T.; Magdeleno, Raymond E.

    1987-01-01

    Nap-Of-the-Earth (NOE) flight in a conventional helicopter is extremely taxing for two pilots under visual conditions. Developing a single pilot all-weather NOE capability will require a fully automatic NOE navigation and flight control capability for which innovative guidance and control concepts were examined. Constrained time-optimality provides a validated criterion for automatically controlled NOE maneuvers if the pilot is to have confidence in the automated maneuvering technique. A second focus was to organize the storage and real-time updating of NOE terrain profiles and obstacles in course-oriented coordinates indexed to the mission flight plan. A method is presented for using pre-flight geodetic parameter identification to establish guidance commands for planned flight profiles and alternates. A method is then suggested for interpolating this guidance command information with the aid of forward and side looking sensors within the resolution of the stored data base, enriching the data content with real-time display, guidance, and control purposes. A third focus defined a class of automatic anticipative guidance algorithms and necessary data preview requirements to follow the vertical, lateral, and longitudinal guidance commands dictated by the updated flight profiles and to address the effects of processing delays in digital guidance and control system candidates. The results of this three-fold research effort offer promising alternatives designed to gain pilot acceptance for automatic guidance and control of rotorcraft in NOE operations.

  1. The Development of a Lifelong Guidance System in Hungary

    ERIC Educational Resources Information Center

    Watts, A. G.; Borbely-Pecze, Bors Tibor

    2011-01-01

    The development of a lifelong guidance system in Hungary Systematic work is currently being undertaken in Hungary to develop a lifelong guidance system, in line with principles outlined by leading international organisations. The origins of career guidance in Hungary, and the nature of the current career guidance system, are outlined. The main…

  2. 76 FR 61098 - Guidance for 1-Hour SO2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ...Notice is hereby given that the EPA has posted its draft non- binding guidance titled, ``Guidance for 1-Hour SO2 NAAQS SIP Submissions'' on its Web site. The EPA invites public comments on this guidance document during the comment period specified below, and plans to issue an updated version of the guidance after reviewing timely submitted...

  3. 14 CFR 25.1329 - Flight guidance system.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... disengagement of any automatic control function of a flight guidance system may not cause a transient response...-normal conditions, disengagement of any automatic control function of a flight guidance system may not... range, a means must be provided to prevent the flight guidance system from providing guidance or...

  4. 14 CFR 25.1329 - Flight guidance system.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... disengagement of any automatic control function of a flight guidance system may not cause a transient response...-normal conditions, disengagement of any automatic control function of a flight guidance system may not... range, a means must be provided to prevent the flight guidance system from providing guidance or...

  5. Constituent Aspects of Workplace Guidance in Secondary VET

    ERIC Educational Resources Information Center

    Swager, Robert; Klarus, Ruud; van Merriënboer, Jeroen J. G.; Nieuwenhuis, Loek F. M.

    2015-01-01

    Purpose: This paper aims to present an integrated model of workplace guidance to enhance awareness of what constitutes good guidance, to improve workplace guidance practices in vocational education and training. Design/methodology/approach: To identify constituent aspects of workplace guidance, a systematic search of Web of Science was conducted,…

  6. 2 CFR 182.40 - How is the guidance maintained?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false How is the guidance maintained? 182.40 Section 182.40 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS...) § 182.40 How is the guidance maintained? The OMB publishes proposed changes to the guidance in...

  7. 32 CFR 2001.16 - Fundamental classification guidance review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Fundamental classification guidance review. 2001... INFORMATION Classification § 2001.16 Fundamental classification guidance review. (a) Performance of fundamental classification guidance reviews. An initial fundamental classification guidance review shall...

  8. Non-Participation in Guidance: An Opportunity for Development?

    ERIC Educational Resources Information Center

    Thomsen, Rie

    2014-01-01

    This article discusses how new opportunities for guidance can emerge from an analysis of the interplay between the participation (or lack of participation) of the individuals in career guidance, and the career guidance practitioner's response. The article suggests critical psychology as a framework for career guidance research and presents…

  9. Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance.

    PubMed

    2006-10-11

    and validly measure the specific concepts at issue. The glossary defines many of the terms used in this guidance. In particular, the term instrument refers to the actual questions or items contained in a questionnaire or interview schedule along with all the additional information and documentation that supports the use of these items in producing a PRO measure (e.g., interviewer training and instructions, scoring and interpretation manual). The term conceptual framework refers to how items are grouped according to subconcepts or domains (e.g., the item walking without help may be grouped with another item, walking with difficulty, within the domain of ambulation, and ambulation may be further grouped into the concept of physical ability). FDA's guidance documents, including this guidance, do not establish legally enforceable responsibilities. Instead, guidance documents describe the Agency's current thinking on a topic and should be viewed only as recommendations, unless specific regulatory or statutory requirements are cited. The use of the word should in Agency guidance documents means that something is suggested or recommended but not required. First publication of the Draft Guidance by the Food and Drug Administration--February 2006.

  10. Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance

    PubMed Central

    2006-01-01

    and validly measure the specific concepts at issue. The glossary defines many of the terms used in this guidance. In particular, the term instrument refers to the actual questions or items contained in a questionnaire or interview schedule along with all the additional information and documentation that supports the use of these items in producing a PRO measure (e.g., interviewer training and instructions, scoring and interpretation manual). The term conceptual framework refers to how items are grouped according to subconcepts or domains (e.g., the item walking without help may be grouped with another item, walking with difficulty, within the domain of ambulation, and ambulation may be further grouped into the concept of physical ability). FDA's guidance documents, including this guidance, do not establish legally enforceable responsibilities. Instead, guidance documents describe the Agency's current thinking on a topic and should be viewed only as recommendations, unless specific regulatory or statutory requirements are cited. The use of the word should in Agency guidance documents means that something is suggested or recommended but not required. First publication of the Draft Guidance by the Food and Drug Administration- February 2006. PMID:17034633

  11. Feasibility Study of Needle Placement in Percutaneous Vertebroplasty: Cone-Beam Computed Tomography Guidance Versus Conventional Fluoroscopy

    SciTech Connect

    Braak, Sicco J.; Zuurmond, Kirsten Aerts, Hans C. J.; Leersum, Marc van Overtoom, Timotheus T. Th. Heesewijk, Johannes P. M. van Strijen, Marco J. L. van

    2013-08-01

    ObjectiveTo investigate the accuracy, procedure time, fluoroscopy time, and dose area product (DAP) of needle placement during percutaneous vertebroplasty (PVP) using cone-beam computed tomography (CBCT) guidance versus fluoroscopy.Materials and MethodsOn 4 spine phantoms with 11 vertebrae (Th7-L5), 4 interventional radiologists (2 experienced with CBCT guidance and two inexperienced) punctured all vertebrae in a bipedicular fashion. Each side was randomization to either CBCT guidance or fluoroscopy. CBCT guidance is a sophisticated needle guidance technique using CBCT, navigation software, and real-time fluoroscopy. The placement of the needle had to be to a specific target point. After the procedure, CBCT was performed to determine the accuracy, procedure time, fluoroscopy time, and DAP. Analysis of the difference between methods and experience level was performed.ResultsMean accuracy using CBCT guidance (2.61 mm) was significantly better compared with fluoroscopy (5.86 mm) (p < 0.0001). Procedure time was in favor of fluoroscopy (7.39 vs. 10.13 min; p = 0.001). Fluoroscopy time during CBCT guidance was lower, but this difference is not significant (71.3 vs. 95.8 s; p = 0.056). DAP values for CBCT guidance and fluoroscopy were 514 and 174 mGy cm{sup 2}, respectively (p < 0.0001). There was a significant difference in favor of experienced CBCT guidance users regarding accuracy for both methods, procedure time of CBCT guidance, and added DAP values for fluoroscopy.ConclusionCBCT guidance allows users to perform PVP more accurately at the cost of higher patient dose and longer procedure time. Because procedural complications (e.g., cement leakage) are related to the accuracy of the needle placement, improvements in accuracy are clinically relevant. Training in CBCT guidance is essential to achieve greater accuracy and decrease procedure time/dose values.

  12. Using Xenopus laevis retinal and spinal neurons to study mechanisms of axon guidance in vivo and in vitro.

    PubMed

    Erdogan, Burcu; Ebbert, Patrick T; Lowery, Laura Anne

    2016-03-01

    The intricate and precise establishment of neuronal connections in the developing nervous system relies on accurate navigation of growing axons. Since Ramón y Cajal's discovery of the growth cone, the phenomenon of axon guidance has been revealed as a coordinated operation of guidance molecules, receptors, secondary messengers, and responses driven by the dynamic cytoskeleton within the growth cone. With the advent of new and accelerating techniques, Xenopus laevis emerged as a robust model to investigate neuronal circuit formation during development. We present here the advantages of the Xenopus nervous system to our growing understanding of axon guidance.

  13. Evaluation of Model-Based Training for Vertical Guidance Logic

    NASA Technical Reports Server (NTRS)

    Feary, Michael; Palmer, Everett; Sherry, Lance; Polson, Peter; Alkin, Marty; McCrobie, Dan; Kelley, Jerry; Rosekind, Mark (Technical Monitor)

    1997-01-01

    This paper will summarize the results of a study which introduces a structured, model based approach to learning how the automated vertical guidance system works on a modern commercial air transport. The study proposes a framework to provide accurate and complete information in an attempt to eliminate confusion about 'what the system is doing'. This study will examine a structured methodology for organizing the ideas on which the system was designed, communicating this information through the training material, and displaying it in the airplane. Previous research on model-based, computer aided instructional technology has shown reductions in the amount of time to a specified level of competence. The lessons learned from the development of these technologies are well suited for use with the design methodology which was used to develop the vertical guidance logic for a large commercial air transport. The design methodology presents the model from which to derive the training material, and the content of information to be displayed to the operator. The study consists of a 2 X 2 factorial experiment which will compare a new method of training vertical guidance logic and a new type of display. The format of the material used to derive both the training and the display will be provided by the Operational Procedure Methodology. The training condition will compare current training material to the new structured format. The display condition will involve a change of the content of the information displayed into pieces that agree with the concepts with which the system was designed.

  14. Transportation control measure: State Implementation Plan guidance (revised final report)

    SciTech Connect

    Eisinger, D.S.; Deakin, E.A.; Mahoney, L.A.; Morris, R.E.; Ireson, R.G.

    1990-09-01

    The document has been developed for the United States Environmental Protection Agency to summarize current knowledge about transportation control measures (TCMs). The target audience includes transportation and air quality management staff at all government levels. The guidance development effort is motivated by the need to provide post-1987 guidance to attain National Ambient Air Quality Standards (NAAQS). The document provides descriptions and examples of the most frequently implemented TCMs; institutional guidance such as assessing feasibility, agency responsibilities, and funding; and techniques for monitoring and enforcing TCMs. In addition, the document describes the tools available for evaluating TCM impacts on hydrocarbons, nitrogen oxides, and carbon monoxide emissions. Appendices present approaches to estimate TCM effects on PM-10 emissions; important sources of additional information; implementation experiences in various cities; and rules of thumb to quantitatively evaluate TCM transportation system effects. The information presented demonstrates that there have been significant advances in TCM development over the past decade, and that TCMs are appropriate control options for state implementation plans.

  15. X-Ray Calibration Facility/Advanced Video Guidance Sensor Test

    NASA Technical Reports Server (NTRS)

    Johnston, N. A. S.; Howard, R. T.; Watson, D. W.

    2004-01-01

    The advanced video guidance sensor was tested in the X-Ray Calibration facility at Marshall Space Flight Center to establish performance during vacuum. Two sensors were tested and a timeline for each are presented. The sensor and test facility are discussed briefly. A new test stand was also developed. A table establishing sensor bias and spot size growth for several ranges is detailed along with testing anomalies.

  16. A predictor-corrector guidance algorithm for use in high-energy aerobraking system studies

    NASA Technical Reports Server (NTRS)

    Braun, Robert D.; Powell, Richard W.

    1991-01-01

    A three-degree-of-freedom predictor-corrector guidance algorithm has been developed specifically for use in high-energy aerobraking performance evaluations. The present study reports on both the development and capabilities of this guidance algorithm to the design of manned Mars aero-braking vehicles. Atmospheric simulations are performed to demonstrate the applicability of this algorithm and to evaluate the effect of atmospheric uncertainties upon the mission requirements. The off-nominal conditions simulated result from atmospheric density and aerodynamic characteristic mispredictions. The guidance algorithm is also used to provide relief from the high deceleration levels typically encountered in a high-energy aerobraking mission profile. Through this analysis, bank-angle modulation is shown to be an effective means of providing deceleration relief. Furthermore, the capability of the guidance algorithm to manage off-nominal vehicle aerodynamic and atmospheric density variations is demonstrated.

  17. 77 FR 10662 - Guidance for Industry: Questions and Answers Regarding Establishment and Maintenance of Records...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ... processors. In the Federal Register of December 9, 2004 (69 FR 71562), FDA published a final rule... Health Security and Bioterrorism Preparedness and Response Act of 2002. The final rule requires...

  18. 76 FR 41803 - Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... devices that detect either influenza viral antigens or influenza viral genome (protein or nucleic acid..., hardware and software, use of fresh and frozen specimens, nucleic acids extraction methods,...

  19. 76 FR 27331 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    .... trachomatis and/or N. gonorrhoeae screening and diagnostic testing using nucleic acid based assays. This draft.... trachomatis and/or N. gonorrhoeae screening and diagnostic testing using nucleic acid based assays. These... characteristics of devices that detect chlamydial and/or gonococcal nucleic acid. It does not address detection...

  20. 76 FR 569 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... for the Detection and Differentiation of Methicillin-Resistant Staphylococcus aureus and Staphylococcus aureus; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. ] SUMMARY: The... Detection and Differentiation of Methicillin-Resistant Staphylococcus aureus (MRSA) and...

  1. 76 FR 34999 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... Methicillin-Resistant Staphylococcus Aureus for Culture-Based Devices; Availability AGENCY: Food and Drug... Diagnostic Devices for the Detection of Methicillin-Resistant Staphylococcus Aureus for Culture- Based... Staphylococcus Aureus (MRSA) for Culture-Based Devices'' to the Division of Small Manufacturers,...

  2. 77 FR 13999 - Notice of Availability and Opportunity for Comments (Establishment Guidance for the Selection of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-08

    ...; ] DEPARTMENT OF AGRICULTURE Food Safety and Inspection Service Notice of Availability and Opportunity for... Laboratory) AGENCY: Food Safety and Inspection Service, USDA. ACTION: Notice of availability and opportunity for comments. SUMMARY: The Food Safety and Inspection Service (FSIS) is announcing the availability...

  3. 75 FR 75628 - Final Guidance for Federal Departments and Agencies on Establishing, Applying, and Revising...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-06

    ... supplies consistent with applicable acquisition and environmental standards) should not require extensive... National Environmental Policy Act, 75 FR 8045, Feb. 23, 2010. Process for Developing and Using Categorical... NEPA Regulations,'' 48 FR 34,263, 34,265, Jul. 28, 1983, available on http://www.nepa.gov at...

  4. Launch flexibility using NLP guidance and remote wind sensing

    NASA Technical Reports Server (NTRS)

    Cramer, Evin J.; Bradt, Jerre E.; Hardtla, John W.

    1990-01-01

    This paper examines the use of lidar wind measurements in the implementation of a guidance strategy for a nonlinear programming (NLP) launch guidance algorithm. The NLP algorithm uses B-spline command function representation for flexibility in the design of the guidance steering commands. Using this algorithm, the guidance system solves a two-point boundary value problem at each guidance update. The specification of different boundary value problems at each guidance update provides flexibility that can be used in the design of the guidance strategy. The algorithm can use lidar wind measurements for on pad guidance retargeting and for load limiting guidance steering commands. Examples presented in the paper use simulated wind updates to correct wind induced final orbit errors and to adjust the guidance steering commands to limit the product of the dynamic pressure and angle-of-attack for launch vehicle load alleviation.

  5. Radiation Protection Guidance for Diagnostic and Interventional X-Ray Procedures; Federal Guidance Report No. 14

    EPA Science Inventory

    Federal Guidance Report No. 14 provides federal facilities that use diagnostic and interventional x-ray equipment with updated recommendations for keeping doses as low as reasonably achievable without compromising the quality of patient care, This guidance is an update of Federal...

  6. The Status of Career Guidance in Michigan Schools. An Opinion Research Study of Career Guidance Professionals.

    ERIC Educational Resources Information Center

    Michigan State Dept. of Education, Lansing.

    Project Outreach, the opinion research division of the Michigan State Board of Education, conducted a study on the current status of career guidance in Michigan public schools, using in-depth telephone interviews with career guidance professionals (N=445) in November and December of 1989. The interview questionnaire, developed with the advice of…

  7. Raising the Profile of Career Guidance: Educational and Vocational Guidance Practitioner

    ERIC Educational Resources Information Center

    Hiebert, Bryan

    2009-01-01

    In 2007 the International Association for Educational and Vocational Guidance (IAEVG) launched the Educational and Vocational Guidance Practitioner credential (EVGP) as one means of formally acknowledging the knowledge, skills, and personal attributes that practitioners need in order to provide quality career development services to clients. This…

  8. Constrained reconstructions for 4D intervention guidance.

    PubMed

    Kuntz, J; Flach, B; Kueres, R; Semmler, W; Kachelriess, M; Bartling, S

    2013-05-21

    Image-guided interventions are an increasingly important part of clinical minimally invasive procedures. However, up to now they cannot be performed under 4D (3D + time) guidance due to the exceedingly high x-ray dose. In this work we investigate the applicability of compressed sensing reconstructions for highly undersampled CT datasets combined with the incorporation of prior images in order to yield low dose 4D intervention guidance. We present a new reconstruction scheme prior image dynamic interventional CT (PrIDICT) that accounts for specific image features in intervention guidance and compare it to PICCS and ASD-POCS. The optimal parameters for the dose per projection and the numbers of projections per reconstruction are determined in phantom simulations and measurements. In vivo experiments in six pigs are performed in a cone-beam CT; measured doses are compared to current gold-standard intervention guidance represented by a clinical fluoroscopy system. Phantom studies show maximum image quality for identical overall doses in the range of 14 to 21 projections per reconstruction. In vivo studies reveal that interventional materials can be followed in 4D visualization and that PrIDICT, compared to PICCS and ASD-POCS, shows superior reconstruction results and fewer artifacts in the periphery with dose in the order of biplane fluoroscopy. These results suggest that 4D intervention guidance can be realized with today's flat detector and gantry systems using the herein presented reconstruction scheme.

  9. Fine Guidance Sensing for Coronagraphic Observatories

    NASA Technical Reports Server (NTRS)

    Brugarolas, Paul; Alexander, James W.; Trauger, John T.; Moody, Dwight C.

    2011-01-01

    Three options have been developed for Fine Guidance Sensing (FGS) for coronagraphic observatories using a Fine Guidance Camera within a coronagraphic instrument. Coronagraphic observatories require very fine precision pointing in order to image faint objects at very small distances from a target star. The Fine Guidance Camera measures the direction to the target star. The first option, referred to as Spot, was to collect all of the light reflected from a coronagraph occulter onto a focal plane, producing an Airy-type point spread function (PSF). This would allow almost all of the starlight from the central star to be used for centroiding. The second approach, referred to as Punctured Disk, collects the light that bypasses a central obscuration, producing a PSF with a punctured central disk. The final approach, referred to as Lyot, collects light after passing through the occulter at the Lyot stop. The study includes generation of representative images for each option by the science team, followed by an engineering evaluation of a centroiding or a photometric algorithm for each option. After the alignment of the coronagraph to the fine guidance system, a "nulling" point on the FGS focal point is determined by calibration. This alignment is implemented by a fine alignment mechanism that is part of the fine guidance camera selection mirror. If the star images meet the modeling assumptions, and the star "centroid" can be driven to that nulling point, the contrast for the coronagraph will be maximized.

  10. Constrained reconstructions for 4D intervention guidance

    NASA Astrophysics Data System (ADS)

    Kuntz, J.; Flach, B.; Kueres, R.; Semmler, W.; Kachelrieß, M.; Bartling, S.

    2013-05-01

    Image-guided interventions are an increasingly important part of clinical minimally invasive procedures. However, up to now they cannot be performed under 4D (3D + time) guidance due to the exceedingly high x-ray dose. In this work we investigate the applicability of compressed sensing reconstructions for highly undersampled CT datasets combined with the incorporation of prior images in order to yield low dose 4D intervention guidance. We present a new reconstruction scheme prior image dynamic interventional CT (PrIDICT) that accounts for specific image features in intervention guidance and compare it to PICCS and ASD-POCS. The optimal parameters for the dose per projection and the numbers of projections per reconstruction are determined in phantom simulations and measurements. In vivo experiments in six pigs are performed in a cone-beam CT; measured doses are compared to current gold-standard intervention guidance represented by a clinical fluoroscopy system. Phantom studies show maximum image quality for identical overall doses in the range of 14 to 21 projections per reconstruction. In vivo studies reveal that interventional materials can be followed in 4D visualization and that PrIDICT, compared to PICCS and ASD-POCS, shows superior reconstruction results and fewer artifacts in the periphery with dose in the order of biplane fluoroscopy. These results suggest that 4D intervention guidance can be realized with today’s flat detector and gantry systems using the herein presented reconstruction scheme.

  11. Safety of magnetic fusion facilities: Guidance

    SciTech Connect

    1996-05-01

    This document provides guidance for the implementation of the requirements identified in DOE-STD-6002-96, Safety of Magnetic Fusion Facilities: Requirements. This guidance is intended for the managers, designers, operators, and other personnel with safety responsibilities for facilities designated as magnetic fusion facilities. While the requirements in DOE-STD-6002-96 are generally applicable to a wide range of fusion facilities, this Standard, DOE-STD-6003-96, is concerned mainly with the implementation of those requirements in large facilities such as the International Thermonuclear Experimental Reactor (ITER). Using a risk-based prioritization, the concepts presented here may also be applied to other magnetic fusion facilities. This Standard is oriented toward regulation in the Department of Energy (DOE) environment as opposed to regulation by other regulatory agencies. As the need for guidance involving other types of fusion facilities or other regulatory environments emerges, additional guidance volumes should be prepared. The concepts, processes, and recommendations set forth here are for guidance only. They will contribute to safety at magnetic fusion facilities.

  12. 76 FR 16425 - Guidance for Industry and Food and Drug Administration Staff; Class II Special Controls Guidance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ...; Class II Special Controls Guidance Document: Ovarian Adnexal Mass Assessment Score Test System... Controls Guidance Document: Ovarian Adnexal Mass Assessment Score Test System.'' This guidance document... system, but it remains subject to comment in accordance with the agency's good guidance practices...

  13. Measuring Integrated Socioemotional Guidance at School: Factor Structure and Reliability of the Socioemotional Guidance Questionnaire (SEG-Q)

    ERIC Educational Resources Information Center

    Jacobs, Karen; Struyf, Elke

    2013-01-01

    Socioemotional guidance of students has recently become an integral part of education, however no instrument exists to measure integrated socioemotional guidance. This study therefore examines the factor structure and reliability of the Socioemotional Guidance Questionnaire. Psychometric properties of the Socioemotional Guidance Questionnaire and…

  14. Evaluation of low-dose limits in 3D-2D rigid registration for surgical guidance

    NASA Astrophysics Data System (ADS)

    Uneri, A.; Wang, A. S.; Otake, Y.; Kleinszig, G.; Vogt, S.; Khanna, A. J.; Gallia, G. L.; Gokaslan, Z. L.; Siewerdsen, J. H.

    2014-09-01

    An algorithm for intensity-based 3D-2D registration of CT and C-arm fluoroscopy is evaluated for use in surgical guidance, specifically considering the low-dose limits of the fluoroscopic x-ray projections. The registration method is based on a framework using the covariance matrix adaptation evolution strategy (CMA-ES) to identify the 3D patient pose that maximizes the gradient information similarity metric. Registration performance was evaluated in an anthropomorphic head phantom emulating intracranial neurosurgery, using target registration error (TRE) to characterize accuracy and robustness in terms of 95% confidence upper bound in comparison to that of an infrared surgical tracking system. Three clinical scenarios were considered: (1) single-view image + guidance, wherein a single x-ray projection is used for visualization and 3D-2D guidance; (2) dual-view image + guidance, wherein one projection is acquired for visualization, combined with a second (lower-dose) projection acquired at a different C-arm angle for 3D-2D guidance; and (3) dual-view guidance, wherein both projections are acquired at low dose for the purpose of 3D-2D guidance alone (not visualization). In each case, registration accuracy was evaluated as a function of the entrance surface dose associated with the projection view(s). Results indicate that images acquired at a dose as low as 4 μGy (approximately one-tenth the dose of a typical fluoroscopic frame) were sufficient to provide TRE comparable or superior to that of conventional surgical tracking, allowing 3D-2D guidance at a level of dose that is at most 10% greater than conventional fluoroscopy (scenario #2) and potentially reducing the dose to approximately 20% of the level in a conventional fluoroscopically guided procedure (scenario #3).

  15. Decision Guidance for Sustainable Manufacturing

    ERIC Educational Resources Information Center

    Shao, Guodong

    2013-01-01

    Sustainable manufacturing has significant impacts on a company's business performance and competitiveness in today's world. A growing number of manufacturing industries are initiating efforts to address sustainability issues; however, to achieve a higher level of sustainability, manufacturers need methodologies for formally describing, analyzing,…

  16. VTOL shipboard letdown guidance system analysis

    NASA Technical Reports Server (NTRS)

    Phatak, A. V.; Karmali, M. S.

    1983-01-01

    Alternative letdown guidance strategies are examined for landing of a VTOL aircraft onboard a small aviation ship under adverse environmental conditions. Off line computer simulation of shipboard landing task is utilized for assessing the relative merits of the proposed guidance schemes. The touchdown performance of a nominal constant rate of descent (CROD) letdown strategy serves as a benchmark for ranking the performance of the alternative letdown schemes. Analysis of ship motion time histories indicates the existence of an alternating sequence of quiescent and rough motions called lulls and swells. A real time algorithms lull/swell classification based upon ship motion pattern features is developed. The classification algorithm is used to command a go/no go signal to indicate the initiation and termination of an acceptable landing window. Simulation results show that such a go/no go pattern based letdown guidance strategy improves touchdown performance.

  17. [Guidance for education on medicines in school].

    PubMed

    Kito, Hideaki

    2013-01-01

    To promote the education on medicines in school, guidance is, as a rule, to be given in the health education of the Subject, "Health and Physical Education" indicated as a curriculum standard in lower and upper secondary school, and in the health guidance, which carry out in Special Activities and Integrated Studies, etc. Guidance is mainly carried by the teacher for health and physical in health education and school nurse teacher (yogo teacher) in health guidance. In health education we have only limited school hours, and generally use the text book. Some teachers feel resistance to teach medicines because of needs on the special knowledge, however teachers should deal with medicines based on curriculum standard. School pharmacist is a member of school, and has a special knowledge for medicines, and he/she can support teachers as a provider of teaching materials, an adviser, and for a guest teacher. It is important for school pharmacist to understand the contents indicated in curriculum standard and to use glossary to be able to understand for children. In the guidance of health, it is not necessary to teach based on curriculum standard, and it can deal with advanced contents on medicines. However it is important to understand for children what are appropriate contents according to the development stage. To use the packages and instructions for medicines provided at home are good materials for children to have interest the medicines in their guidance. The objectives of education on medicines enable children to cultivate practical abilities for the maintenance and improvement of health. PMID:24292178

  18. Virtual Ultrasound Guidance for Inexperienced Operators

    NASA Technical Reports Server (NTRS)

    Caine, Timothy; Martin, David

    2012-01-01

    Medical ultrasound or echocardiographic studies are highly operator-dependent and generally require lengthy training and internship to perfect. To obtain quality echocardiographic images in remote environments, such as on-orbit, remote guidance of studies has been employed. This technique involves minimal training for the user, coupled with remote guidance from an expert. When real-time communication or expert guidance is not available, a more autonomous system of guiding an inexperienced operator through an ultrasound study is needed. One example would be missions beyond low Earth orbit in which the time delay inherent with communication will make remote guidance impractical. The Virtual Ultrasound Guidance system is a combination of hardware and software. The hardware portion includes, but is not limited to, video glasses that allow hands-free, full-screen viewing. The glasses also allow the operator a substantial field of view below the glasses to view and operate the ultrasound system. The software is a comprehensive video program designed to guide an inexperienced operator through a detailed ultrasound or echocardiographic study without extensive training or guidance from the ground. The program contains a detailed description using video and audio to demonstrate equipment controls, ergonomics of scanning, study protocol, and scanning guidance, including recovery from sub-optimal images. The components used in the initial validation of the system include an Apple iPod Classic third-generation as the video source, and Myvue video glasses. Initially, the program prompts the operator to power-up the ultrasound and position the patient. The operator would put on the video glasses and attach them to the video source. After turning on both devices and the ultrasound system, the audio-video guidance would then instruct on patient positioning and scanning techniques. A detailed scanning protocol follows with descriptions and reference video of each view along with

  19. Development of mining guidance and control systems

    NASA Technical Reports Server (NTRS)

    1979-01-01

    New fundamental interface sensor concepts were identified and investigated including tabulation of the physical and performance characteristics of two new interface detector concepts: - natural background radiation and magnetic spin resonance. Studies of guidance and control techniques for the longwall miner identified three basic systems for use in automated/remote controlled longwall mining. The following projects were initiated: system study which will more completely define the longwall guidance and control system design concepts; integration of the various control functions (vertical, yaw, and roll); and hardware technical requirements.

  20. Ascent guidance algorithm using lidar wind measurements

    NASA Technical Reports Server (NTRS)

    Cramer, Evin J.; Bradt, Jerre E.; Hardtla, John W.

    1990-01-01

    The formulation of a general nonlinear programming guidance algorithm that incorporates wind measurements in the computation of ascent guidance steering commands is discussed. A nonlinear programming (NLP) algorithm that is designed to solve a very general problem has the potential to address the diversity demanded by future launch systems. Using B-splines for the command functional form allows the NLP algorithm to adjust the shape of the command profile to achieve optimal performance. The algorithm flexibility is demonstrated by simulation of ascent with dynamic loading constraints through a set of random wind profiles with and without wind sensing capability.

  1. Overcoming consumer inertia to dietary guidance.

    PubMed

    Webb, Densie; Byrd-Bredbenner, Carol

    2015-07-01

    Despite 35 y of dietary guidance, there has been no substantial shift in consumer compliance. Consumers report that they seek information on nutrition and healthy eating, but most are not paying attention to dietary recommendations. For guidance to be effective, it must be realistic. Even with increasingly detailed nutrition information and evidence that diet affects health outcomes, convenience and taste remain the strongest determinants of food choices. It is up to health educators to clear up confusion and give consumers control with nutrition messages that are realistic, positive, easy to understand, and actionable without an expectation that consumers will surrender foods they love. PMID:26178023

  2. Overcoming Consumer Inertia to Dietary Guidance12

    PubMed Central

    Webb, Densie; Byrd-Bredbenner, Carol

    2015-01-01

    Despite 35 y of dietary guidance, there has been no substantial shift in consumer compliance. Consumers report that they seek information on nutrition and healthy eating, but most are not paying attention to dietary recommendations. For guidance to be effective, it must be realistic. Even with increasingly detailed nutrition information and evidence that diet affects health outcomes, convenience and taste remain the strongest determinants of food choices. It is up to health educators to clear up confusion and give consumers control with nutrition messages that are realistic, positive, easy to understand, and actionable without an expectation that consumers will surrender foods they love. PMID:26178023

  3. Aerospace plane guidance using geometric control theory

    NASA Technical Reports Server (NTRS)

    Van Buren, Mark A.; Mease, Kenneth D.

    1990-01-01

    A reduced-order method employing decomposition, based on time-scale separation, of the 4-D state space in a 2-D slow manifold and a family of 2-D fast manifolds is shown to provide an excellent approximation to the full-order minimum-fuel ascent trajectory. Near-optimal guidance is obtained by tracking the reduced-order trajectory. The tracking problem is solved as regulation problems on the family of fast manifolds, using the exact linearization methodology from nonlinear geometric control theory. The validity of the overall guidance approach is indicated by simulation.

  4. Overcoming consumer inertia to dietary guidance.

    PubMed

    Webb, Densie; Byrd-Bredbenner, Carol

    2015-07-01

    Despite 35 y of dietary guidance, there has been no substantial shift in consumer compliance. Consumers report that they seek information on nutrition and healthy eating, but most are not paying attention to dietary recommendations. For guidance to be effective, it must be realistic. Even with increasingly detailed nutrition information and evidence that diet affects health outcomes, convenience and taste remain the strongest determinants of food choices. It is up to health educators to clear up confusion and give consumers control with nutrition messages that are realistic, positive, easy to understand, and actionable without an expectation that consumers will surrender foods they love.

  5. Aeroassist flight experiment guidance, navigation and control

    NASA Technical Reports Server (NTRS)

    Brand, Timothy J.; Engel, Albert G.

    1986-01-01

    The Aeroassist Flight Experiment scheduled for the early 1990's will demonstrate the use of a low L/D lifting brake using aerodynamic drag to return a spacecraft from a high energy to a low earth orbit. The experimental vehicle will be deployed and retrieved by the Shuttle Orbiter. This paper reviews some of the challenges, problems, and solutions encountered to date during guidance system development, with emphasis on technology advances which will benefit an operational Orbit Transfer Vehicle (OTV). Key factors to be discussed include guidance alternatives, aerodynamic modeling, navigation requirements, the impact of atmospheric uncertainties, and flight profile alternatives considered during initial planning.

  6. The Effects of a Counselor-Led Guidance Intervention on Students' Behaviors and Attitudes.

    ERIC Educational Resources Information Center

    Schlossberg, Sharon M.; Morris, John D.; Lieberman, Mary G.

    2001-01-01

    Study investigated the impact of a counselor-led guidance unit on ninth-grade students, and the interaction of the intervention with risk levels, academic placements, and gender. Students' expressed behavior, school attitudes, and level of informational awareness about high school and the work world were assessed. Results showed these guidance…

  7. The Impact of Conflicting Perceptions on the Role and Function of High School Guidance Counselors

    ERIC Educational Resources Information Center

    Natividad, Larry D.

    2010-01-01

    A counselor's academic guidance is critical because student stress levels are high due to increased levels of expectations that they perform at their best (Campbell & Dahir, 1997; Gysbers & Henderson, 2000). In the last decade, education reform has moved towards more standards-driven curriculum/a, basic skills acquisition, and accountability…

  8. An analysis of physical guidance as reinforcement for noncompliance.

    PubMed

    Kern, Lee; Delaney, Beth A; Hilt, Alexandra; Bailin, Deborah E; Elliot, Christina

    2002-09-01

    Physical guidance is a strategy commonly used for noncompliance. In two experiments, we evaluated reinforcing effects of physical guidance. Experiment 1 include three individuals with developmental disabilities who were noncompliant with tasks. Anecdotal observations indicated physical contact was highly reinforcing, and a functional analysis identified attention as a reinforcer for problem behavior. Two conditions compared physical guidance following noncompliance and no physical guidance following noncompliance. Results showed noncompliance increased for all three participants when physical guidance followed noncompliance. The second experiment empirically evaluated the function of noncompliance prior to examining the effect of physical guidance on noncompliance. A functional analysis, conducted with two participants, indicated noncompliance served an escape function for one and an attention function for the other. Comparisons of physical guidance and no physical guidance indicated physical guidance resulted in decreased noncompliance for the participant with an escape function but increased noncompliance for the participant with an attention function. PMID:12205825

  9. Non-singular terminal dynamic surface control based integrated guidance and control design and simulation.

    PubMed

    Cong, Zhang; Yun-Jie, Wu

    2016-07-01

    In this paper, a novel cascade type design model is transformed from the simulation model, which has a broader scope of application, for integrated guidance and control (IGC). A novel non-singular terminal dynamic surface control based IGC method is proposed. It can guarantee the missile with multiple disturbances fast hits the target with high accuracy, while considering the terminal impact angular constraint commendably. And the stability of the closed-loop system is strictly proved. The essence of integrated guidance and control design philosophy is reached that establishing a direct relation between guidance and attitude equations by "intermediate states" and then designing an IGC law for the obtained integrated cascade design model. Finally, a series of simulations and comparisons with a 6-DOF nonlinear missile that includes all aerodynamic effects are demonstrated to illustrate the effectiveness and advantage of the proposed IGC method.

  10. Non-singular terminal dynamic surface control based integrated guidance and control design and simulation.

    PubMed

    Cong, Zhang; Yun-Jie, Wu

    2016-07-01

    In this paper, a novel cascade type design model is transformed from the simulation model, which has a broader scope of application, for integrated guidance and control (IGC). A novel non-singular terminal dynamic surface control based IGC method is proposed. It can guarantee the missile with multiple disturbances fast hits the target with high accuracy, while considering the terminal impact angular constraint commendably. And the stability of the closed-loop system is strictly proved. The essence of integrated guidance and control design philosophy is reached that establishing a direct relation between guidance and attitude equations by "intermediate states" and then designing an IGC law for the obtained integrated cascade design model. Finally, a series of simulations and comparisons with a 6-DOF nonlinear missile that includes all aerodynamic effects are demonstrated to illustrate the effectiveness and advantage of the proposed IGC method. PMID:27049772

  11. The effect of haptic guidance and visual feedback on learning a complex tennis task.

    PubMed

    Marchal-Crespo, Laura; van Raai, Mark; Rauter, Georg; Wolf, Peter; Riener, Robert

    2013-11-01

    While haptic guidance can improve ongoing performance of a motor task, several studies have found that it ultimately impairs motor learning. However, some recent studies suggest that the haptic demonstration of optimal timing, rather than movement magnitude, enhances learning in subjects trained with haptic guidance. Timing of an action plays a crucial role in the proper accomplishment of many motor skills, such as hitting a moving object (discrete timing task) or learning a velocity profile (time-critical tracking task). The aim of the present study is to evaluate which feedback conditions-visual or haptic guidance-optimize learning of the discrete and continuous elements of a timing task. The experiment consisted in performing a fast tennis forehand stroke in a virtual environment. A tendon-based parallel robot connected to the end of a racket was used to apply haptic guidance during training. In two different experiments, we evaluated which feedback condition was more adequate for learning: (1) a time-dependent discrete task-learning to start a tennis stroke and (2) a tracking task-learning to follow a velocity profile. The effect that the task difficulty and subject's initial skill level have on the selection of the optimal training condition was further evaluated. Results showed that the training condition that maximizes learning of the discrete time-dependent motor task depends on the subjects' initial skill level. Haptic guidance was especially suitable for less-skilled subjects and in especially difficult discrete tasks, while visual feedback seems to benefit more skilled subjects. Additionally, haptic guidance seemed to promote learning in a time-critical tracking task, while visual feedback tended to deteriorate the performance independently of the task difficulty and subjects' initial skill level. Haptic guidance outperformed visual feedback, although additional studies are needed to further analyze the effect of other types of feedback visualization on

  12. Levels at gaging stations

    USGS Publications Warehouse

    Kenney, Terry A.

    2010-01-01

    Operational procedures at U.S. Geological Survey gaging stations include periodic leveling checks to ensure that gages are accurately set to the established gage datum. Differential leveling techniques are used to determine elevations for reference marks, reference points, all gages, and the water surface. The techniques presented in this manual provide guidance on instruments and methods that ensure gaging-station levels are run to both a high precision and accuracy. Levels are run at gaging stations whenever differences in gage readings are unresolved, stations may have been damaged, or according to a pre-determined frequency. Engineer's levels, both optical levels and electronic digital levels, are commonly used for gaging-station levels. Collimation tests should be run at least once a week for any week that levels are run, and the absolute value of the collimation error cannot exceed 0.003 foot/100 feet (ft). An acceptable set of gaging-station levels consists of a minimum of two foresights, each from a different instrument height, taken on at least two independent reference marks, all reference points, all gages, and the water surface. The initial instrument height is determined from another independent reference mark, known as the origin, or base reference mark. The absolute value of the closure error of a leveling circuit must be less than or equal to ft, where n is the total number of instrument setups, and may not exceed |0.015| ft regardless of the number of instrument setups. Closure error for a leveling circuit is distributed by instrument setup and adjusted elevations are determined. Side shots in a level circuit are assessed by examining the differences between the adjusted first and second elevations for each objective point in the circuit. The absolute value of these differences must be less than or equal to 0.005 ft. Final elevations for objective points are determined by averaging the valid adjusted first and second elevations. If final elevations

  13. Semantic guidance of eye movements in real-world scenes

    PubMed Central

    Hwang, Alex D.; Wang, Hsueh-Cheng; Pomplun, Marc

    2011-01-01

    The perception of objects in our visual world is influenced by not only their low-level visual features such as shape and color, but also their high-level features such as meaning and semantic relations among them. While it has been shown that low-level features in real-world scenes guide eye movements during scene inspection and search, the influence of semantic similarity among scene objects on eye movements in such situations has not been investigated. Here we study guidance of eye movements by semantic similarity among objects during real-world scene inspection and search. By selecting scenes from the LabelMe object-annotated image database and applying Latent Semantic Analysis (LSA) to the object labels, we generated semantic saliency maps of real-world scenes based on the semantic similarity of scene objects to the currently fixated object or the search target. An ROC analysis of these maps as predictors of subjects’ gaze transitions between objects during scene inspection revealed a preference for transitions to objects that were semantically similar to the currently inspected one. Furthermore, during the course of a scene search, subjects’ eye movements were progressively guided toward objects that were semantically similar to the search target. These findings demonstrate substantial semantic guidance of eye movements in real-world scenes and show its importance for understanding real-world attentional control. PMID:21426914

  14. Equipping Every Student with Psychological Tools: A Vygotskian Guide to Establishing the Goals of Education

    ERIC Educational Resources Information Center

    Eun, Barohny

    2016-01-01

    The present conceptual analysis begins with an assertion that the most fundamental act in any educational endeavors is establishing their goals. The discussion proceeds to reviewing recent pertinent literature that presents Vygotsky's theory of development as a useful source in providing guidance to establishing the goals of education in rapidly…

  15. Report on EU guidance on groundwater monitoring developed under the common implementation strategy of the water framework directive.

    PubMed

    Grath, Johannes; Ward, Rob; Scheidleder, Andreas; Quevauviller, Philippe

    2007-11-01

    The establishment of high quality long-term monitoring programmes is essential if the implementation of the Water Framework Directive (WFD) is to be effective. It is recognised that monitoring can be very expensive and so guidance is needed to establish cost-effective, risk-based and targeted groundwater monitoring across Europe that enables WFD objectives to be met. In this context, the Groundwater Working Group (WGC) of the Common Implementation Strategy (CIS) of the WFD has developed recommendations aiming to implement consistent groundwater monitoring across Europe. This has been published on the internet in the form of a non-legally binding guidance document, which provides useful elements for the development and maintenance of networks at high standards and thereby provide the necessary information to assess (ground)water status, identify trends in pollutant concentrations, support establishment and assessment of programmes of measures and the effective targeting of economic resources. This paper presents this guidance document.

  16. Deep Energy Retrofit Guidance for the Building America Solutions Center

    SciTech Connect

    Less, Brennan; Walker, Iain

    2015-01-01

    The U.S. DOE Building America program has established a research agenda targeting market-relevant strategies to achieve 40% reductions in existing home energy use by 2030. Deep Energy Retrofits (DERs) are part of the strategy to meet and exceed this goal. DERs are projects that create new, valuable assets from existing residences, by bringing homes into alignment with the expectations of the 21st century. Ideally, high energy using, dated homes that are failing to provide adequate modern services to their owners and occupants (e.g., comfortable temperatures, acceptable humidity, clean, healthy), are transformed through comprehensive upgrades to the building envelope, services and miscellaneous loads into next generation high performance homes. These guidance documents provide information to aid in the broader market adoption of DERs. They are intended for inclusion in the online resource the Building America Solutions Center (BASC). This document is an assemblage of multiple entries in the BASC, each of which addresses a specific aspect of Deep Energy Retrofit best practices for projects targeting at least 50% energy reductions. The contents are based upon a review of actual DERs in the U.S., as well as a mixture of engineering judgment, published guidance from DOE research in technologies and DERs, simulations of cost-optimal DERs, Energy Star and Consortium for Energy Efficiency (CEE) product criteria, and energy codes.

  17. Apollo experience report guidance and control systems: Primary guidance, navigation, and control system development

    NASA Technical Reports Server (NTRS)

    Holley, M. D.; Swingle, W. L.; Bachman, S. L.; Leblanc, C. J.; Howard, H. T.; Biggs, H. M.

    1976-01-01

    The primary guidance, navigation, and control systems for both the lunar module and the command module are described. Development of the Apollo primary guidance systems is traced from adaptation of the Polaris Mark II system through evolution from Block I to Block II configurations; the discussion includes design concepts used, test and qualification programs performed, and major problems encountered. The major subsystems (inertial, computer, and optical) are covered. Separate sections on the inertial components (gyroscopes and accelerometers) are presented because these components represent a major contribution to the success of the primary guidance, navigation, and control system.

  18. Vehicle Battery Safety Roadmap Guidance

    SciTech Connect

    Doughty, D. H.

    2012-10-01

    The safety of electrified vehicles with high capacity energy storage devices creates challenges that must be met to assure commercial acceptance of EVs and HEVs. High performance vehicular traction energy storage systems must be intrinsically tolerant of abusive conditions: overcharge, short circuit, crush, fire exposure, overdischarge, and mechanical shock and vibration. Fail-safe responses to these conditions must be designed into the system, at the materials and the system level, through selection of materials and safety devices that will further reduce the probability of single cell failure and preclude propagation of failure to adjacent cells. One of the most important objectives of DOE's Office of Vehicle Technologies is to support the development of lithium ion batteries that are safe and abuse tolerant in electric drive vehicles. This Roadmap analyzes battery safety and failure modes of state-of-the-art cells and batteries and makes recommendations on future investments that would further DOE's mission.

  19. GUIDANCE FOR NUCLEAR POWER PLANT CONTROL ROOM AND HUMAN-SYSTEM INTERFACE MODERNIZATION

    SciTech Connect

    Naser, J.; Morris, G.

    2004-10-06

    Several nuclear power plants in the United States are starting instrumentation and control (I&C) modernization programs using digital equipment to address obsolescence issues and the need to improve plant performance while maintaining high levels of safety. As an integral part of the I&C modernization program at a nuclear power plant, the control room and other human-system interfaces (HSIs) are also being modernized. To support safe and effective operation, it is critical to plan, design, implement, train for, operate, and maintain the control room and HSI changes to take advantage of human cognitive processing abilities. A project, jointly funded by the Electric Power Research Institute (EPRI) and the United States Department of Energy (DOE) under the Nuclear Energy Plant Optimization (NEPO) Program, is developing guidance for specifying and designing control rooms, remote shut-down panels, HSIs etc. The guidance is intended for application by utilities and suppliers of control room and HSI modernization. The guidance will facilitate specification, design, implementation, operations, maintenance, training, and licensing activities. This guidance will be used to reduce the likelihood of human errors and licensing risk, to gain maximum benefit of implemented technology, and to increase performance. The guidance is of five types. The first is planning guidance to help a utility develop its plant-specific control room operating concepts, its plant-specific endpoint vision for the control room, its migration path to achieve that endpoint vision, and its regulatory, licensing, and human factors program plans. The second is process guidance for general HSI design and integration, human factors engineering analyses, verification and validation, in-service monitoring processes, etc. The third is detailed human factors engineering guidance for control room and HSI technical areas. The fourth is guidance for licensing. The fifth is guidance for special topics related to

  20. 33 CFR 385.5 - Guidance memoranda.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Guidance memoranda. 385.5 Section 385.5 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE PROGRAMMATIC REGULATIONS FOR THE COMPREHENSIVE EVERGLADES RESTORATION PLAN General...

  1. 75 FR 76011 - Annual Guidance Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    .... SUPPLEMENTARY INFORMATION: I. Background In the Federal Register of September 19, 2000 (65 FR 56468), FDA issued... existing guidance documents (65 FR 56468 at 56477; 21 CFR 10.115(f)(5)). The Agency is neither bound by... . Calorie Declaration Vincent DeJesus, CFSAN (HFS- 830), Food and Drug Administration, 5100 Paint...

  2. Hypermedia Authoring with Writing Process Guidance

    ERIC Educational Resources Information Center

    Chang, Kuo-En; Sung, Yao-Ting; Zheng, Jie-Wen

    2007-01-01

    A writing process of five stages, setting the topic and goals, planning the outline, organising the structure, building the content, and reviewing, is proposed to guide hypermedia authoring. To explore the effects of the system designed with writing-process guidance, this study enrolled 108 seventh graders at a junior high school as experimental…

  3. Museum Personnel's Opinions on Mobile Guidance Systems

    ERIC Educational Resources Information Center

    Yoshimura, Hirokazu; Sekiguchi, Hiromi; Yabumoto, Yoshitaka

    2007-01-01

    While opinions from the general public are certainly important, opinions from the museum staff are also necessary to improve user service systems. this article introduces two groups of museum staff who have evaluated the usability of mobile guidance systems in Japanese museums. One group is the research team who used the PDA system in the National…

  4. 21 CFR 601.29 - Guidance documents.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... for Biologics Evaluation and Research (CBER) maintains a list of guidance documents that apply to the... Register. You may request a copy of the CBER list from the Office of Communication, Training, and Manufacturers Assistance (HFM-40), Center for Biologics Evaluation and Research, Food and Drug...

  5. 21 CFR 312.145 - Guidance documents.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... requirements of this part. (b) The Center for Drug Evaluation and Research (CDER) and the Center for Biologics Evaluation and Research (CBER) maintain lists of guidance documents that apply to the centers' regulations... for a copy of the CDER list should be directed to the Office of Training and Communications,...

  6. Career Guidance and the Kuder Interest Inventories.

    ERIC Educational Resources Information Center

    Science Research Associates, Inc., Chicago, IL.

    The manual suggests various uses the guidance counselor can make of the Kuder interest surveys. Written by a counselor, the guide presents suggestions that reflect considerable experience with the Kuder tests. Guidelines for introducing, administering, and interpreting the instrument are included along with suggestions for ways to involve the…

  7. Bridge over Troubled Water: Guidance Crosses

    ERIC Educational Resources Information Center

    Amundson, Norm

    2008-01-01

    This article is based on a keynote presentation at an international conference where the focus was cross-over career guidance. Simon and Garfunkel's popular song, "Bridge over troubled water", was used as a metaphor for exploring the cross-over theme. Some of the concepts under consideration included the working alliance, the importance of a…

  8. The Spanish Family Guidance Center of Miami.

    ERIC Educational Resources Information Center

    Hispanic Research Center: Research Bulletin, 1979

    1979-01-01

    Two major programs of the Spanish Family Guidance Center, a facility that addresses the mental health needs of Hispanics in the Greater Miami (Florida) area, are described in this report. One program, the Spanish Drug Rehabilitation Project (completed in 1977), compared a series of activities including: (1) research on the characteristics of…

  9. 77 FR 48591 - State Rail Plan Guidance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477), or visit... Federal Railroad Administration State Rail Plan Guidance AGENCY: Federal Railroad Administration (FRA), Department of Transportation (DOT). ACTION: Request for Public Comment on Proposed State Rail Plan...

  10. Guidance and Counseling Research in New Zealand.

    ERIC Educational Resources Information Center

    Small, J. J.

    This review of guidance and counseling research includes reports of hypothesis testing based on hard data and behavioral analysis designs, reports of surveys and evaluations, and comments and recommenda- tions from reflections on experience and survey findings. The materials, originating from New Zealand between 1970 and 1979, are classified on…

  11. Evaluating Computer-Assisted Career Guidance Programs.

    ERIC Educational Resources Information Center

    Krumboltz, John D.

    1990-01-01

    Finds the Sampson et al. guidelines for computer-assisted career guidance systems (CE 521 972) comprehensive and self-explanatory, but states that user judgment is still required. Suggests revision of existing standards to take into account the feature-cost analysis method. (SK)

  12. Guidance for performing site inspections under CERCLA

    SciTech Connect

    Not Available

    1992-09-01

    This guidance presents EPA`s site inspection (SI) strategy. The strategy discusses procedural guidelines to investigate potential Superfund (CERCLA) sites for evaluation pursuant to the Hazard Ranking System (HRS), revised in accordance with the Superfund Amendments and Reauthorization Act of 1986. The HRS is the primary means by which EPA evaluates sites for superfund`s National Priorities List (NPL).

  13. Guidance and control of flight vehicles

    NASA Technical Reports Server (NTRS)

    Breakwell, J. V.; Bryson, A. E., Jr.; Franklin, G. F.

    1971-01-01

    Progress reports on guidance and attitude control mechanisms of different flight vehicles are presented. The vehicles considered include orbiting spacecraft, supersonic aircraft, and general aviation aircraft. Data also cover orbital transfer using low thrust, automatic landing logic for aircraft, optimal and three dimensional turns for supersonic aircraft, and orbital rendezvous.

  14. 36 CFR 1290.7 - Additional guidance.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 1290.7 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION JFK... ASSASSINATION RECORDS COLLECTION ACT OF 1992 (JFK ACT) § 1290.7 Additional guidance. (a) A government agency, office, or entity includes, for purposes of interpreting and implementing the JFK Act, all current,...

  15. 36 CFR 1290.7 - Additional guidance.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 1290.7 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION JFK... ASSASSINATION RECORDS COLLECTION ACT OF 1992 (JFK ACT) § 1290.7 Additional guidance. (a) A government agency, office, or entity includes, for purposes of interpreting and implementing the JFK Act, all current,...

  16. 36 CFR 1290.7 - Additional guidance.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 1290.7 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION JFK... ASSASSINATION RECORDS COLLECTION ACT OF 1992 (JFK ACT) § 1290.7 Additional guidance. (a) A government agency, office, or entity includes, for purposes of interpreting and implementing the JFK Act, all current,...

  17. 36 CFR 1290.7 - Additional guidance.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 1290.7 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION JFK... ASSASSINATION RECORDS COLLECTION ACT OF 1992 (JFK ACT) § 1290.7 Additional guidance. (a) A government agency, office, or entity includes, for purposes of interpreting and implementing the JFK Act, all current,...

  18. ASSESSMENT OF THE DEMONSTRATION GUIDANCE PROJECT.

    ERIC Educational Resources Information Center

    WRIGHTSTONE, J. WAYNE; AND OTHERS

    THE PURPOSE WAS TO IDENTIFY ABLE STUDENTS FROM DISADVANTAGED URBAN AREAS AND TO STIMULATE THEM THROUGH CULTURAL EXPERIENCES, SPECIAL CLASSES, AND GUIDANCE TO SEEK HIGHER EDUCATIONAL AND VOCATIONAL GOALS. A PRIMARY OBJECTIVE WAS TO REFINE THE METHODS AND TECHNIQUES FOR PREDICTION OF ACADEMIC POTENTIAL, THROUGH APTITUDE TESTING, ACHIEVEMENT TESTING,…

  19. Effective Child Guidance: An Educator's Guidebook.

    ERIC Educational Resources Information Center

    Hill, Brent Mathews

    This guidebook is designed to assist educators in becoming more effective child guidance leaders within the school system. Sections discuss the following areas: (1) indicators of current emotional problems; (2) children's common emotional problems, including fears, separation and loss, misbehavior motivations, aggressiveness, stealing, lying,…

  20. Occupational Information. A Career Guidance View.

    ERIC Educational Resources Information Center

    Wolfbein, Seymour L.

    This book deals not with the administrative or information searching processes related to the guidance function of providing occupational information, but with the substantive information itself. It presents a contemporary view of values, trends, and principles, derived primarily from statistical information describing the current world of work.…

  1. Modern control theory for Army missile guidance

    NASA Astrophysics Data System (ADS)

    Travassos, R. H.; Levari, H.; Gupta, N. K.

    1982-11-01

    A Singular perturbation guidance law has been developed for medium-range surface-to-air missiles. This guidance law is a significant extension of a previously developed guidance law for short-range missiles; in medium-range intercepts, the problem of energy management should be addressed in addition to homing guidance. The mathematical formulation has been simplified by introducing separation of time scales. Target Trajectory Estimation: A recursive algorithm for estimation of autoregressive moving average (ARMA) model parameters from noisy samples has been developed. Application of this algorithm to parameter estimation problems has exhibited its fast convergence and unbiasedness in the presence of noise, even with short data records. The algorithm has two versions, a Recursive Maximum Likelihood (RML) form and a Recursive Prediction Error (RPE) form, both of which possess a parallel structure that makes them highly suitable for parallel-processing implementation. Adaptive autopilots: Lattice-form algorithms have been developed for fast, recursive identification and control of time-varying systems. These algorithms have excellent numerical properties and a modular structure that makes them suitable for on-board real-time implementation.

  2. Assessing Enterprise Capability: Guidance for Schools

    ERIC Educational Resources Information Center

    National Foundation for Educational Research, 2007

    2007-01-01

    This document offers guidance to schools on how assessment can support enterprise education. It presents the interim findings from research carried out by the National Foundation for Educational Research (NFER) for the Department for Education and Skills (DfES) in secondary schools in England. Enterprise capability is the key outcome of enterprise…

  3. Vocational Guidance for Women, 1910-1940.

    ERIC Educational Resources Information Center

    Rossiter, Margaret W.

    The kinds of vocational guidance available to women from 1910 to 1940 are discussed in this paper. As the number of women college graduates increased in the 1890s and especially in the first decade of the 20th century, concern also grew for what all these trained women would do to earn a living after they graduated and before they married (if they…

  4. MR imaging guidance for minimally invasive procedures

    NASA Astrophysics Data System (ADS)

    Wong, Terence Z.; Kettenbach, Joachim; Silverman, Stuart G.; Schwartz, Richard B.; Morrison, Paul R.; Kacher, Daniel F.; Jolesz, Ferenc A.

    1998-04-01

    Image guidance is one of the major challenges common to all minimally invasive procedures including biopsy, thermal ablation, endoscopy, and laparoscopy. This is essential for (1) identifying the target lesion, (2) planning the minimally invasive approach, and (3) monitoring the therapy as it progresses. MRI is an ideal imaging modality for this purpose, providing high soft tissue contrast and multiplanar imaging, capability with no ionizing radiation. An interventional/surgical MRI suite has been developed at Brigham and Women's Hospital which provides multiplanar imaging guidance during surgery, biopsy, and thermal ablation procedures. The 0.5T MRI system (General Electric Signa SP) features open vertical access, allowing intraoperative imaging to be performed. An integrated navigational system permits near real-time control of imaging planes, and provides interactive guidance for positioning various diagnostic and therapeutic probes. MR imaging can also be used to monitor cryotherapy as well as high temperature thermal ablation procedures sing RF, laser, microwave, or focused ultrasound. Design features of the interventional MRI system will be discussed, and techniques will be described for interactive image acquisition and tracking of interventional instruments. Applications for interactive and near-real-time imaging will be presented as well as examples of specific procedures performed using MRI guidance.

  5. Laser radar for spacecraft guidance applications

    NASA Technical Reports Server (NTRS)

    Liebe, C. C.; Abramovici, A.; Bartman, R. K.; Bunker, R. L.; Chapsky, J.; Chu, C. C.; Clouse, D.; Dillon, J. W.; Hausmann, B.; Hemmati, H.; Kornfeld, R. P.; Kwa, C.; Mobasser, S.; Newell, M.; Padgett, C.; Roberts, W. T.; Spiers, G.; Warfield, Z.; Wright, M.

    2003-01-01

    A flight qualified laser radar called LAMP (LAser MaPper) is under development at JPL. LAMP is a guidance and control sensor that can form 3 dimensional images of its field of regard. This paper describes the detailed design of the LAMP sensor.

  6. From the Church to the Guidance Department.

    ERIC Educational Resources Information Center

    Fraser, Bruce W.

    1979-01-01

    The religious instituations seem to be experiencing an exodus of young people from active participation, but those who leave are not rejecting life, they are simply looking for answers from different sources. Guidance counselors have opportunities to assist the young people who come to them in several ways. (Author)

  7. The Computerized Educational Guidance System. EDGUYD Manual.

    ERIC Educational Resources Information Center

    Cassel, Russell N.

    The Computerized Educational Guidance System (EDGUYD) permits one to narrow post high school educational planning where consideration is given to all 1,448 4-year colleges and universities in the United States. This, to be sure, is a feat no human counselor is capable of without a computer. The Educational Success Index (ESI) is the means used by…

  8. Advisory List of Instructional Media Guidance.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Instruction, Raleigh.

    A bibliography of materials relevant to the competency-based guidance curriculum of the North Carolina State Department of Public Instruction is presented in this document. Books for students, books for teacher/counselor use, filmstrips (sound), and videocassettes are listed. Grade ranges are provided for each item, although use of the materials…

  9. Using Project TALENT to Improve Vocational Guidance.

    ERIC Educational Resources Information Center

    Jones, G. Brian

    The problem of assisting students to consider vocational-educational opportunities is discussed. To meet the needs of prospective vocational education students, a guidance system must help them in educational and vocational planning; interest them in the exploration of training opportunities, and motivate them to seek information and pursue…

  10. Guidance for an aeroassisted orbital transfer vehicle

    NASA Technical Reports Server (NTRS)

    Hall, Kenneth R.

    1988-01-01

    The use of atmospheric drag for slowing satellite in high energy, high apogee orbits to a lower energy, lower apogee orbit about the Earth is investigated. The high energy orbit is assumed to intercept the Earth's atmosphere. Guidance for the atmospheric phase of the trajectory may be done using the aerodynamic forces generated by the passage through the atmosphere. This research was concerned with the investigation of several methods of guidance during the atmospheric phase to cause a significant reduction in the final velocity as the vehicle leaves the atmosphere. In addition, the velocity direction was controlled to exit to a desired target orbit. Lastly excess aerodynamic lift was used to effect a plane change between the entry orbit plane and the exit orbit plane to achieve a desired orbit plane. The guidance methods were applied to a 3 degree-of-freedom simulation which included an oblate Earth gravity model and a rotating atmosphere. Simulation results were compared on the basis of speed of computation of the guidance parameters and amount of added velocity necessary to achieve the desired orbit.

  11. Career Guidance and Counseling: Recent Legislation.

    ERIC Educational Resources Information Center

    Cunanan, Esmeralda S.; Maddy-Bernstein, Carolyn

    1995-01-01

    The Perkins Act of 1990 and the School to Work Opportunities Act (STWOA) of 1994 both contain explicit provisions regarding career guidance and counseling provisions for special populations. The Perkins Act sets the direction for state and local agencies as they develop vocational and applied education programs to equip youth and adults with the…

  12. Neighboring optimal guidance theory and computer program

    NASA Technical Reports Server (NTRS)

    Powers, W. F.

    1974-01-01

    Developments of the linear quadratic optimal control problem are discussed. The theory is applicable to the development of neighboring optimal feedback guidance gains, and is useful as a tool for synthesizing feedback control laws. A computer program which requires only the pertinent matrices of the linear quadratic problem is described.

  13. Intuitive Educational and Vocational Guidance in Togo.

    ERIC Educational Resources Information Center

    McFadden, John; Djassoa, Gnansa C.

    1985-01-01

    Describes the process of intuitive educational and vocational guidance in Togo by examining the pattern of socialization of an individual in this society and the stylistic dimensions of counseling. Discusses the role of the family and teachers as well as the National Council for Scholarship. (JAC)

  14. A Four-Year Career Guidance Program.

    ERIC Educational Resources Information Center

    Sherrell, C. Eleanor; Spaulding, Barbara G.

    The counseling staff at a suburban, comprehensive, four-year high school in southern California developed and implemented a Career Guidance program for grades nine through twelve. With assistance and cooperation from teachers, students participated in exploration of vocational interests, personal values, and individual aptitudes in Grades 9 and…

  15. Second Annual Career Guidance Institute: Final Report.

    ERIC Educational Resources Information Center

    Schenck, Norma Elaine

    The document reports on the organization and implementation plans for Indiana's Second Annual Career Guidance Institute and the sound/slide programs developed on six career cluster areas. An extensive evaluation analyzes the Institute in light of its objectives, offers insights gained on career opportunities, gives changes in attitude regarding…

  16. 28 CFR 91.53 - Other guidance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Impact Review Procedures for VOI/TIS Grant Program In General § 91.53 Other guidance. The Department of Justice has also published NEPA procedures that incorporate the CEQ regulations at 28 CFR part 61. Additionally, the Office of Justice Programs' Corrections Program Office has prepared a handbook for...

  17. IUS guidance algorithm gamma guide assessment

    NASA Technical Reports Server (NTRS)

    Bray, R. E.; Dauro, V. A.

    1980-01-01

    The Gamma Guidance Algorithm which controls the inertial upper stage is described. The results of an independent assessment of the algorithm's performance in satisfying the NASA missions' targeting objectives are presented. The results of a launch window analysis for a Galileo mission, and suggested improvements are included.

  18. Epilepsy in the Classroom: Guidance for Educators.

    ERIC Educational Resources Information Center

    Lassner, Lee M.

    This paper for educators, school psychologists, and counselors attempts to provide guidance for meeting the needs of students with epilepsy. Stressed throughout the paper are ways to provide for the child's special needs while fostering his/her self esteem and full participation in classroom activities. The paper addresses the following topics:…

  19. "Telling Tales": Using Narrative in Career Guidance

    ERIC Educational Resources Information Center

    Reid, Hazel; West, Linden

    2011-01-01

    In this article the authors argue for the importance of narrative-based approaches in career guidance work in an uncertain, unpredictable world. This requires a paradigmatic shift in thinking that can be too difficult, at present, for some practitioners. The article reports on the first phase of a collaborative project with a group of…

  20. The role of repulsive guidance molecules in the embryonic and adult vertebrate central nervous system

    PubMed Central

    Mueller, Bernhard K; Yamashita, Toshihide; Schaffar, Gregor; Mueller, Reinhold

    2006-01-01

    During the development of the nervous system, outgrowing axons often have to travel long distances to reach their target neurons. In this process, outgrowing neurites tipped with motile growth cones rely on guidance cues present in their local environment. These cues are detected by specific receptors expressed on growth cones and neurites and influence the trajectory of the growing fibres. Neurite growth, guidance, target innervation and synapse formation and maturation are the processes that occur predominantly but not exclusively during embryonic or early post-natal development in vertebrates. As a result, a functional neural network is established, which is usually remarkably stable. However, the stability of the neural network in higher vertebrates comes at an expensive price, i.e. the loss of any significant ability to regenerate injured or damaged neuronal connections in their central nervous system (CNS). Most importantly, neurite growth inhibitors prevent any regenerative growth of injured nerve fibres. Some of these inhibitors are associated with CNS myelin, others are found at the lesion site and in the scar tissue. Traumatic injuries in brain and spinal cord of mammals induce upregulation of embryonic inhibitory or repulsive guidance cues and their receptors on the neurites. An example for embryonic repulsive directional cues re-expressed at lesion sites in both the rat and human CNS is provided with repulsive guidance molecules, a new family of directional guidance cues. PMID:16939972

  1. Advances in spacecraft atmospheric entry guidance

    NASA Astrophysics Data System (ADS)

    Benito Manrique, Joel

    In order to advance entry guidance technology two different research areas have been explored with the objective of increasing the reachable landing area and the landing accuracy for future Mars missions. Currently only the northern hemisphere of Mars is available for landing due to its low elevation. Only low elevation landing sites have the necessary atmospheric density to allow landing using current Entry, Descent and Landing (EDL) technology. In order to reach most of the Ancient Highlands, the majority of the southern hemisphere, advanced EDL technology is needed in multiple fields, including entry guidance. The first research area is the definition and applications of reachable and controllable sets for entry. The definition of the reachable and controllable sets provides a framework for the study of the capabilities of an entry vehicle in a given planet. Reachable and controllable sets can be used to comprehensively characterize the envelope of trajectories that a vehicle can fly, the sites it can reach and the entry states that can be accommodated. The sets can also be used for the evaluation of trajectory planning algorithms and to assist in the selection of the entry or landing sites. In essence, the reachable and controllable sets offer a powerful vehicle and trajectory analysis and design framework that allows for better mission design choices. In order to illustrate the use of the sets, they are computed for a representative Mars mission using two different vehicle configurations. The sets characterize the impact of the vehicle configuration on the entry capability. Furthermore, the sets are used to find the best skip-entry trajectory for a return from the Moon mission, highlighting the utility of the sets in atmospheric maneuvers other than entry. The second research area is the development of the components of an entry guidance algorithm that allow high elevation landing and provide as well high landing accuracy. The approach taken follows the

  2. Establishment of Intestinal Bacteriology

    PubMed Central

    MITSUOKA, Tomotari

    2014-01-01

    Research on intestinal bacteria began around the end of the 19th century. During the last 5 decades of the 20th century, research on the intestinal microbiota made rapid progress. At first, in my work, I first developed a method of comprehensive analysis of the intestinal microbiota, and then I established classification and identification methods for intestinal anaerobes. Using these methods I discovered a number of ecological rules governing the intestinal microbiota and the role of the intestinl microbiota in health and disease. Moreover, using germfree animals, it was proven that the intestinal microbiota has a role in carcinogenesis and aging in the host. Thus, a new interdisciplinary field, “intestinal bacteriology” was established. PMID:25032084

  3. Establishing and sustaining a biorepository network in Israel: challenges and progress.

    PubMed

    Cohen, Yehudit; Almog, Ronit; Onn, Amir; Itzhaki-Alfia, Ayelet; Meir, Karen

    2013-12-01

    Over the past 5 years, using European and North American biobanks as models, the grass-roots establishment of independently operating biobanks has occurred virtually simultaneously in large Israeli teaching hospitals. The process of establishing a national biorepository network in Israel has progressed slowly, sustained mainly by a few proponents working together on a personal level. Slow progress has been due to limited funding and the lack of a legal framework specific to biobanking activities. Recently, due to increasing pressure from the scientific community, the government has earmarked funds for a national biorepository network, and the structure is now being established. In forming a network, Israel's biobanks face certain difficulties, particularly lack of support. Additional challenges include harmonization of standard operating procedures, database centralization, and use of a common informed consent form. In this article, we highlight some of the issues faced by Israel's biobank managers in establishing and sustaining a functional biobank network, information that could provide guidance for other small countries with limited resources.

  4. Juvenile fibromyalgia: Guidance for management.

    PubMed

    Yokota, Shumpei; Kikuchi, Masako; Miyamae, Takako

    2013-08-01

    Juvenile fibromyalgia (JFM) is a disease in which patients complain of acute and chronic severe pain, an overt primary cause for which cannot be found or surmised. Although patients with JFM mainly complain of systemic pain or allodynia in the medical interview and physical examination, the concept of the disease is the total sum of painful illness, chronic fatigue, hypothermia and many other autonomic symptoms and signs. Many issues are interacting including individual traits (personality, temperament, sensitivity, memory of pain; age: early adolescence), individual states (self-esteem, anxiety, developmental level), and external stressors (parent especially mother, school environment). JFM is diagnosed on the combination of disease history, physical examination to determine the 18 tender points and allodynia, pain from gently touching their hair, and negative results of blood tests (inflammatory markers, thyroid function, myogenic enzymes). The goals of treatment are the following: restoration of function and relief of pain. Psychological support is advocated. Although the exact number of patients with JFM is still to be elucidated, it seems to be growing because pediatric rheumatologists in Japan encounter children with a wide variety of musculoskeletal pains. This guideline describes how to diagnose JFM in children and how to treat them appropriately.

  5. Deep Energy Retrofit Guidance for the Building America Solutions Center

    SciTech Connect

    Less, Brennan; Walker, Iain

    2015-01-01

    The U.S. DOE Building America program has established a research agenda targeting market-relevant strategies to achieve 40% reductions in existing home energy use by 2030. Deep Energy Retrofits (DERs) are part of the strategy to meet and exceed this goal. DERs are projects that create new, valuable assets from existing residences, by bringing homes into alignment with the expectations of the 21st century. Ideally, high energy using, dated homes that are failing to provide adequate modern services to their owners and occupants (e.g., comfortable temperatures, acceptable humidity, clean, healthy), are transformed through comprehensive upgrades to the building envelope, services and miscellaneous loads into next generation high performance homes. These guidance documents provide information to aid in the broader market adoption of DERs.

  6. A Formal Investigation of the Organization of Guidance Behavior: Implications for Humans and Autonomous Guidance

    NASA Astrophysics Data System (ADS)

    Kong, Zhaodan

    Guidance behavior generated either by artificial agents or humans has been actively studied in the fields of both robotics and cognitive science. The goals of these two fields are different. The former is the automatic generation of appropriate or even optimal behavior, while the latter is the understanding of the underlying mechanism. Their challenges, though, are closely related, the most important one being the lack of a unified, formal and grounded framework where the guidance behavior can be modeled and studied. This dissertation presents such a framework. In this framework, guidance behavior is analyzed as the closed-loop dynamics of the whole agent-environment system. The resulting dynamics give rise to interaction patterns. The central points of this dissertation are that: first of all, these patterns, which can be explained in terms of symmetries that are inherent to the guidance behavior, provide building blocks for the organization of behavior; second, the existence of these patterns and humans' organization of their guidance behavior based on these patterns are the reasons that humans can generate successful behavior in spite of all the complexities involved in the planning and control. This dissertation first gives an overview of the challenges existing in both scientific endeavors, such as human and animal spatial behavior study, and engineering endeavors, such as autonomous guidance system design. It then lays out the foundation for our formal framework, which states that guidance behavior should be interpreted as the collection of the closed-loop dynamics resulting from the agent's interaction with the environment. The following, illustrated by examples of three different UAVs, shows that the study of the closed-loop dynamics should not be done without the consideration of vehicle dynamics, as is the common practice in some of the studies in both autonomous guidance and human behavior analysis. The framework, the core concepts of which are

  7. Guidance document for revision of DOE Order 5820.2A, Radioactive Waste Technical Support Program. Revision 1

    SciTech Connect

    Kudera, D.E.; McMurtrey, C.D.; Meagher, B.G.

    1993-04-01

    This document provides guidance for the revision of DOE Order 5820.2A, ``Radioactive Waste Management.`` Technical Working Groups have been established and are responsible for writing the revised order. The Technical Working Groups will use this document as a reference for polices and procedures that have been established for the revision process. The overall intent of this guidance is to outline how the order will be revised and how the revision process will be managed. In addition, this document outlines technical issues considered for inclusion by a Department of Energy Steering Committee.

  8. Flu Vaccine Guidance for Patients with Immune Deficiency

    MedlinePlus

    ... Guidance for Patients with Immune Deficiency Share | Flu Vaccine Guidance for Patients with Immune Deficiency This article ... should patients with immune deficiency be given the vaccine? Immune deficient patients have a decreased resistance to ...

  9. Technical Guidance for Assessing Environmental Justice in Regulatory Analysis

    EPA Science Inventory

    The Technical Guidance for Assessing Environmental Justice in Regulatory Analysis (also referred to as the Environmental Justice Technical Guidance or EJTG) is intended for use by Agency analysts, including risk assessors, economists, and other analytic staff that conduct analyse...

  10. [Auditory guidance systems for the visually impaired people].

    PubMed

    He, Jing; Nie, Min; Luo, Lan; Tong, Shanbao; Niu, Jinhai; Zhu, Yisheng

    2010-04-01

    Visually impaired people face many inconveniences because of the loss of vision. Therefore, scientists are trying to design various guidance systems for improving the lives of the blind. Based on sensory substitution, auditory guidance has become an interesting topic in the field of biomedical engineering. In this paper, we made a state-of-technique review of the auditory guidance system. Although there have been many technical challenges, the auditory guidance system would be a useful alternative for the visually impaired people.

  11. A study on method of reentry guidance for manned spacecraft

    NASA Astrophysics Data System (ADS)

    Zhao, Hanyuan; Xie, Xiaoquan

    In this paper, the methods of reentry guidance for manned spacecraft are chiefly studied. To the longitudinal guidance law, the method of choosing feedback gains coefficients k1, k2, and k3 is given. As for the lateral guidance law, the bang-bang control method similar to the 'funnel' is discussed. Calculation indicates that the guidance precision of these means is satisfied with the index of demand.

  12. LIGA Micromachining: Infrastructure Establishment

    SciTech Connect

    Alfredo M. Morales; Barry V. Hess; Dale R. Boehme; Jill M. Hruby; John S. Krafcik; Robert H. Nilson; Stewart K. Griffiths; William D. Bonivert

    1999-02-01

    LIGA is a micromachining technology that uses high energy x-rays from a synchrotron to create patterns with small lateral dimensions in a deep, non-conducting polymeric resist. Typical dimensions for LIGA parts are microns to tens of microns in lateral size, and hundreds of microns to millimeters in depth. Once the resist is patterned, metal is electrodeposited in the features to create metal microparts, or to create a metal mold for subsequent replication. The acronym LIGA comes from the German words for lithography, electroforming, and molding, and the technology has been under worldwide development for more than a decade. over the last five years, a full-service capability to produce metal microparts using the LIGA process has been established at Sandia national Laboratories, California. This report describes the accomplishments made during the past two years in infrastructure establishment funded by a Laboratory Directed Research and Development (LDRD) project entitled ''LIGA Micromachining.'' Specific topics include photoresist processing for LIGA mask making, x-ray scanning equipment, plating bath instrumentation, plating uniformity, and software architecture.

  13. Establishment and Characterization of a Newly Established Diabetic Gerbil Line

    PubMed Central

    Li, Xiaohong; Lu, Jing; Wang, Ying; Huo, Xueyun; Li, Zhenkun; Zhang, Shuangyue; Li, Changlong; Guo, Meng; Du, Xiaoyan; Chen, Zhenwen

    2016-01-01

    Objectives We aimed to selectively breed a spontaneous diabetic gerbil when a sub-line of inbred gerbil showed increased blood glucose levels was found recently. Then we investigated the characteristics including the serum insulin, triglyceride, cholesterol, leptin, adiponectin and explored the underlying molecular mechanism for the diabetic phenotype. Methods The spontaneous diabetic line of gerbils was selectively inbreed the sub-line of gerbil by monitoring blood glucose of each animal. The serum insulin, adiponectin, and leptin levels were tested using an ELISA kit. The expression levels of GLUT4, Akt, leptin, adiponectin, and calpain 10 (CAPN10) were tested by western blot and Quantitative Real-time PCR (qPCR) in liver, skeletal muscle, and white adipose. Results Our results show that the percentages of animals with FPG≥5.2 (mmol/l), PG2h≥6.8 (mmol/l) and both FPG≥5.2 and PG2h≥6.8 (mmol/l) were increased with the number of breeding generations from F0 (21.33%) to F6 (38.46%). These diabetic gerbils exhibited insulin resistance and leptin resistance as well as decreased adiponectin level in the serum. We also observed decreased expression of adiponectin and increased expression of leptin in the skeletal muscle, respectively. Conclusions These results indicate that we have primarily established a spontaneous diabetic gerbil line, and the diabetic phenotypes may have been accounted for by altered expression of leptin and adiponectin. PMID:27427908

  14. Mass Casualty Decontamination Guidance and Psychosocial Aspects of CBRN Incident Management: A Review and Synthesis

    PubMed Central

    Carter, Holly; Amlôt, Richard

    2016-01-01

    Introduction: Mass casualty decontamination is an intervention employed by first responders at the scene of an incident involving noxious contaminants.  Many countries have sought to address the challenge of decontaminating large numbers of affected casualties through the provision of rapidly deployable temporary showering structures, with accompanying decontamination protocols.  In this paper we review decontamination guidance for emergency responders and associated research evidence, in order to establish to what extent psychosocial aspects of casualty management have been considered within these documents. The review focuses on five psychosocial aspects of incident management: likely public behaviour; responder management style; communication strategy; privacy/ modesty concerns; and vulnerable groups. Methods: Two structured literature reviews were carried out; one to identify decontamination guidance documents for first responders, and another to identify evidence which is relevant to the understanding of the psychosocial aspects of mass decontamination.  The guidance documents and relevant research were reviewed to identify whether the guidance documents contain information relating to psychosocial issues and where it exists, that the guidance is consistent with the existing evidence-base. Results: Psychosocial aspects of incident management receive limited attention in current decontamination guidance.  In addition, our review has identified a number of gaps and inconsistencies between guidance and research evidence.  For each of the five areas we identify: what is currently presented in guidance documents, to what extent this is consistent with the existing research evidence and where it diverges.  We present a series of evidence-based recommendations for updating decontamination guidance to address the psychosocial aspects of mass decontamination. Conclusions: Effective communication and respect for casualties’ needs are critical in ensuring

  15. 77 FR 26562 - Mobile Offshore Drilling Unit Dynamic Positioning Guidance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... Guard is publishing this notice to recommend interim voluntary DP system guidance and recommend DP... concern are likely to be the subject of a future rulemaking. II. Interim Voluntary DP System Guidance On..._operations_guidance.cfm . It is particularly important they identify the DP System's Critical Activity...

  16. 14 CFR 25.1329 - Flight guidance system.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Flight guidance system. 25.1329 Section 25... guidance system. (a) Quick disengagement controls for the autopilot and autothrust functions must be... accordance with the requirements of § 25.1309. (c) Engagement or switching of the flight guidance system,...

  17. 43 CFR 1610.1 - Resource management planning guidance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... provided in 40 CFR 1502.6. The disciplines of the preparers shall be appropriate to the values involved and... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Resource management planning guidance... Resource Management Planning § 1610.1 Resource management planning guidance. (a) Guidance for...

  18. 43 CFR 1610.1 - Resource management planning guidance.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... provided in 40 CFR 1502.6. The disciplines of the preparers shall be appropriate to the values involved and... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Resource management planning guidance... Resource Management Planning § 1610.1 Resource management planning guidance. (a) Guidance for...

  19. GUIDANCE GUIDELINES. A HANDBOOK FOR SECONDARY SCHOOL COUNSELORS.

    ERIC Educational Resources Information Center

    EHLERS, DOROTHY; AND OTHERS

    DIRECTIONAL PROCEDURES AND TECHNIQUES FOR ADMINISTERING THE OVERALL PROGRAM OF SECONDARY SCHOOL GUIDANCE ARE PRESENTED. THE MAJOR EMPHASIS OF THIS GUIDANCE PROGRAM IS UPON OCCUPATIONAL, EDUCATIONAL, AND SOCIAL ADJUSTMENT OF ALL THE PUPILS. SERVICES OF THE GUIDANCE PROGRAM ARE DESCRIBED AT LENGTH. THE KEY IS COUNSELING, OF INDIVIDUALS OR GROUPS.…

  20. 75 FR 22681 - Supplemental Guidance on Overdraft Protection Programs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... goals, including building long term customer relationships, cross selling additional products, and... Guidance on Overdraft Protection Programs (Overdraft Guidance) OTS issued February 18, 2005 (70 FR 8428). OTS issued the Overdraft Guidance after notice and comment. See 69 FR 31858 (June 7, 2004)....