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Sample records for ethik fr den

  1. Der evolutionäre Naturalismus in der Ethik

    NASA Astrophysics Data System (ADS)

    Kaiser, Marie I.

    Charles Darwin hat eindrucksvoll gezeigt, dass der Mensch ebenso wie alle anderen Lebewesen ein Produkt der biologischen Evolution ist. Die sich an Darwin anschließende Forschung hat außerdem plausibel gemacht, dass sich nicht nur viele der körperlichen Merkmale des Menschen, sondern auch (zumindest einige) seiner Verhaltensdispositionen in adaptiven Selektionsprozessen herausgebildet haben. Die Vorstellung, dass auch die menschliche Moralität evolutionär bedingt ist, scheint daher auf den ersten Blick ganz überzeugend. Schließlich hat die Evolutionstheorie in den vergangenen Jahrzehnten in vielen Bereichen (auch außerhalb der Biologie) ihre weitreichende Bedeutung unter Beweis gestellt. Warum sollte, so könnte man beispielsweise fragen, gerade die Fähigkeit des Menschen, moralische Normen aufzustellen und gemäß ihnen zu handeln, nicht evolutionär erklärt werden können? Und warum sollte eine solche evolutionäre Erklärung der menschlichen Moralität irrelevant für die Rechtfertigung moralischer Normen sein? Warum sollte die Ethik eine Bastion der Philosophen bleiben, für die evolutionsbiologische Forschungsergebnisse über den Menschen und seine nächsten Verwandten keinerlei Relevanz besitzen?

  2. Two New Letters by Denning

    NASA Astrophysics Data System (ADS)

    Beech, Martin

    2010-06-01

    Two letters written by W. F. Denning to R. P. Greg in March and April of 1879 that had been tucked into the folds of an 1876 edition of the British Association for the Advancement of Science Reports were recently found at the Carnegie Institution in Washington D.C. The letters are wonderfully preserved, and offer us a snap-shot of the work being performed by a young Denning at the time when his influence in the field of meteor studies was in its ascendency. The contents of these two letters is analyzed and placed within context to Denning's other publications and private life.

  3. The DenA/DEN1 Interacting Phosphatase DipA Controls Septa Positioning and Phosphorylation-Dependent Stability of Cytoplasmatic DenA/DEN1 during Fungal Development

    PubMed Central

    Schinke, Josua; Kolog Gulko, Miriam; Christmann, Martin; Valerius, Oliver; Stumpf, Sina Kristin; Stirz, Margarita; Braus, Gerhard H.

    2016-01-01

    DenA/DEN1 and the COP9 signalosome (CSN) represent two deneddylases which remove the ubiquitin-like Nedd8 from modified target proteins and are required for distinct fungal developmental programmes. The cellular DenA/DEN1 population is divided into a nuclear and a cytoplasmatic subpopulation which is especially enriched at septa. DenA/DEN1 stability control mechanisms are different for the two cellular subpopulations and depend on different physical interacting proteins and the C-terminal DenA/DEN1 phosphorylation pattern. Nuclear DenA/DEN1 is destabilized during fungal development by five of the eight CSN subunits which target nuclear DenA/DEN1 for degradation. DenA/DEN1 becomes stabilized as a phosphoprotein at S243/S245 during vegetative growth, which is necessary to support further asexual development. After the initial phase of development, the newly identified cytoplasmatic DenA/DEN1 interacting phosphatase DipA and an additional developmental specific C-terminal phosphorylation site at serine S253 destabilize DenA/DEN1. Outside of the nucleus, DipA is co-transported with DenA/DEN1 in the cytoplasm between septa and nuclei. Deletion of dipA resulted in increased DenA/DEN1 stability in a strain which is unresponsive to illumination. The mutant strain is dysregulated in cytokinesis and impaired in asexual development. Our results suggest a dual phosphorylation-dependent DenA/DEN1 stability control with stabilizing and destabilizing modifications and physical interaction partner proteins which function as control points in the nucleus and the cytoplasm. PMID:27010942

  4. Dens in dente: A minimally invasive nonsurgical approach!

    PubMed Central

    Hegde, Vivek; Morawala, Abdul; Gupta, Abhilasha; Khandwawala, Naqiyaa

    2016-01-01

    Dens invaginatus, also known as dens in dente, is a rare anomaly affecting human dentition. The condition results in invagination of an amelodental structure within the pulp. This case report discusses the current management protocol of dens invaginatus using a minimally invasive and nonsurgical treatment option. As with most conditions, early diagnosis and preventive measures help minimize complications in dens invaginatus cases. PMID:27656073

  5. Dragons' Den: promoting healthcare research and innovation.

    PubMed

    Mazhindu, Deborah; Gregory, Siobhan

    2015-07-01

    The changing health and social care landscape, and, in particular, the financial challenges affecting the NHS, can present difficulties for staff looking for funding to support innovation and new ways of working. One method of competitive tendering that is becoming more accepted as a way of allocating funds, encouraging staff engagement and developing innovation for research is a format based the BBC television series, Dragons' Den. This article describes how Hounslow and Richmond Community Healthcare NHS Trust, London, has developed a 'Dragons' Den initiative' of annual competitive research funding allocation to ensure that some of the most dynamic practice in the trust is captured.

  6. Polar bear maternity denning in the Beaufort Sea

    USGS Publications Warehouse

    Amstrup, S.; Gardner, C.

    1994-01-01

    The distribution of polar bears (Ursus maritimus) is circumpolar in the NOrthern Hemisphere, but known locations of maternal dens are concentrated in relatively few, widely scattered locations. Denning is either uncommon or unknown within gaps. To understand effects of industrial development and propose increases in hunting, the temporal and spatial distribution of denning in the Beaufort Sea must be known. We caputred and radiocollared polar bears between 1981 and 1991 and determined tht denning in the Beaufort Sea region was sufficient to account for the estimated population there. Of 90 dend, 48 were on drifting pack ice, 38 on land, and 4 on land-fast ice. The portions of dens on land was higher (P= 0.029) in later compared with earlier years of the study. Bears denning on pack ice drifting as far as 997 km (x=385km) while in dens. there was no difference in cun production by bears denning on land and pack ice (P =0.66). Mean entry and exit dates were 11 November and 5 April for land dens and 22 November and 26 March for pack-ice dens. Female polar bears captured in the Beaufort Sea appeared to be isolated from those caught eat of Cape Bathurst in Canada. Of 35 polar bears that denned along the mainland coast of Alaska and Canada 80% denned between 137 00'W snf 146 59'W. Bears followed to >1 den did not reuse sites and consecutive dens were 20-1,304 km apart. However radio-collared bears are largely faithful to substrate (pack-ice, land, and land-fast ice) and the general geographic area of previous dens. Bears denning on land may be vunerable to human activities such as hunting and industrial development. However, predictable denning chronology and alck of site fidelity indicate that many potential impacts on denning polar bears could be mitigated.

  7. A rare presentation of multiple dens invaginatus in maxillary dentition.

    PubMed

    Purani, Jigar M; Purani, Hiral J

    2014-08-01

    Dens invaginatus is a developmental disturbance of the tooth and usually occurs in the maxillary lateral incisor of permanent dentition. In this article, a rare case of dens invaginatus affecting multiple permanent maxillary teeth is described.

  8. Dens Evaginatus: A Problem-Based Approach

    PubMed Central

    Ayer, A.; Vikram, M.; Suwal, P.

    2015-01-01

    Dens evaginatus is an uncommon developmental anomaly of human dentition characterized by the presence of tubercle on the occlusal surface of mandibular premolars and lingual surface of anterior teeth. Due to occlusal trauma this tubercle tends to fracture thus exposing the pathway to the pulp chamber of teeth. This case report is about the presentation of dens evaginatus in mandibular premolars bilaterally; among them tooth 44 was associated with chronic apical periodontitis. Fractured tubercle of three premolars was sealed with composite resin. Root canal treatment was performed with tooth 44. Routine endodontic treatment did not result in remission of infection. Therefore, culture and sensitivity tests were performed to identify the cause and modify treatment plan accordingly. Triple antibiotic paste was used as an intracanal medicament to disinfect the root canal that resulted in remission of infection. PMID:26779353

  9. Dysplastic dens of the axis: case report.

    PubMed

    Payer, M; Bijlenga, P; Delavelle, J

    2003-09-01

    In a patient injured in a bicycle accident, radiological evaluation of the cervical spine revealed an oblique orientation of a dysplastic dens of the axis, which, to our knowledge, has not been reported in the literature. There were no other bony or soft tissue anomalies and no associated instability. This case should draw attention to congenital anomalies of the cranio-cervical junction in trauma patients.

  10. Den use by arctic foxes in northern Alaska

    SciTech Connect

    Eberhardt, L.E.; Garrott, R.A.; Hanson, W.C.

    1983-01-01

    Den use by arctic foxes (Alopex lagopus) was examined near the Prudhoe Bay oil field and on a nearby undisturbed area on the Colville River Delta in northern Alaska. The density of dens at Prudhoe Bay (1 den/12 km/sup 2/) was approximately three times that on Colville Delta (1 den/34 km/sup 2/). Thirty-three percent of the Prudhoe Bay dens appeared to be of recent origin compared to 11% on the Colville Delta. Survival or production of juvenile foxes decreased on both study areas in 1977 when densities of lemmings (Dicrostonyx torquatus and Lemmus sibiricus) were low, but the decrease was less pronounced at Prudhoe Bay. Foxes that raised young at Prudhoe Bay in 1977 were those living near petroleum development facilities. The utilization of garbage by Prudhoe Bay foxes probably accounted for many of the observed differences between study sites. Common features of spring and summer den use by arctic foxes included a selection of historically preferred den sites, splitting litters into multiple dens, and the fidelity of some adult and juvenile foxes to dens in successive years. Winter use of dens was common at Prudhoe Bay. 24 references, 2 tables.

  11. Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome.

    PubMed

    Christmann, Martin; Schmaler, Tilo; Gordon, Colin; Huang, Xiaohua; Bayram, Ozgür; Schinke, Josua; Stumpf, Sina; Dubiel, Wolfgang; Braus, Gerhard H

    2013-01-01

    Deneddylases remove the ubiquitin-like protein Nedd8 from modified proteins. An increased deneddylase activity has been associated with various human cancers. In contrast, we show here that a mutant strain of the model fungus Aspergillus nidulans deficient in two deneddylases is viable but can only grow as a filament and is highly impaired for multicellular development. The DEN1/DenA and the COP9 signalosome (CSN) deneddylases physically interact in A. nidulans as well as in human cells, and CSN targets DEN1/DenA for protein degradation. Fungal development responds to light and requires both deneddylases for an appropriate light reaction. In contrast to CSN, which is necessary for sexual development, DEN1/DenA is required for asexual development. The CSN-DEN1/DenA interaction that affects DEN1/DenA protein levels presumably balances cellular deneddylase activity. A deneddylase disequilibrium impairs multicellular development and suggests that control of deneddylase activity is important for multicellular development.

  12. An update of dens invaginatus in the diagnosis and treatment.

    PubMed

    Zhu, Jingjing; Wang, Xinhuan; Fang, Yanjun; Von den Hoff, Johannes W; Meng, Liuyan

    2017-03-17

    Dens invaginatus is a malformation with varying anatomical features, posing challenges to treatment. Early and accurate diagnosis plays a significant role in selecting the appropriate treatment. The diagnosis of teeth with a complex root canal system including dens invaginatus has made progress with the application of three-dimensional imaging techniques in endodontics. Advanced treatment options provide hope for teeth that could not be saved before. This review discusses diagnostic methods and treatment options for teeth with dens invaginatus, and provides guidelines for the management of dens invaginatus cases in clinic. Current as well as traditional diagnostic techniques are summarised. Treatment options including state-of-the-art alternatives are presented for coronal dens invaginatus and radicular dens invaginatus. This article is protected by copyright. All rights reserved.

  13. Denning behaviour of non-gravid wolves, Canis lupus

    USGS Publications Warehouse

    Mech, L.D.; Phillips, M.K.; Smith, D.W.; Kreeger, T.J.

    1996-01-01

    Wild wolves (Canis lupus) that had produced pups in earlier years but were not currently pregnant, and ovariectomized captive wolves, dug dens during and after the whelping season even though they produced no pups. These observations suggest that den digging is not a function of pregnancy or of ovarian estrogen or progesterone. We hypothesize that increasing prolactin in spring elicits or mediates den-digging behavior.

  14. Evaluation Studies of the DEN-2/S-1 Vaccine.

    DTIC Science & Technology

    1981-08-01

    Urbana, IL 61801). This drug was found to have antiviral activity against herpes s.mplex viruses (types I and II), vaccinia, influenza PR8...painfluenza 3, coxsackie A-21 and equine rhinovirus (Dr. Rinehart, personal communication). We have found that Didemnin A reduces plaque formation by DEN-i, DEN...3 and herpes simplex virus type 2 (see figures I and 2). Fifty percent inu- bition of plaque formation by these viruses was observed at drug

  15. Dental abscess in a tooth with intact dens evaginatus.

    PubMed

    Cho, S Y

    2006-03-01

    This article reports a case of dental abscess in a mandibular premolar with intact dens evaginatus. Dentists are advised to critically evaluate those teeth with dens evaginatus, both clinically and radiographically, before attempting prophylactic treatments. This is particularly important medicolegally in case the tooth develops symptoms shortly after the prophylactic treatment. Dentists practising in Western countries should also be aware of this dental anomaly because of the increasing global migration of people from Asia.

  16. Patterns of den occupation by the spotted hyaena (Crocuta crocuta)

    USGS Publications Warehouse

    Boydston, E.E.; Kapheim, K.M.; Holekamp, K.E.

    2006-01-01

    Spotted hyaenas utilize isolated natal dens (NDs) and communal dens (CDs) for rearing their cubs. Here we describe patterns of natal and CD occupation by hyaenas belonging to one well-studied clan in the Maasai Mara National Reserve during a 10-year period. Locations of 98 den sites that were used as natal or CDs by hyaenas in the study clan were digitized in a Geographic Information System, and the duration of use of each den site, frequency of re-use, and distances involved in den moves were quantified. Hyaenas moved their CD monthly on average. Most CD sites were occupied only once during the study, but several sites were used repeatedly. On rare occasions, the movement of hyaenas to a new den site could be attributed to a disturbance event at the CD, but factors regularly prompting hyaenas to move to new CD sites were unclear. High-ranking female hyaenas were more likely to rear their cubs from birth in a CD than low-ranking females. Low-ranking females almost always utilized isolated NDs for the first few weeks of a litter's development, and low-ranking females transferred their cubs over longer distances than did high-ranking females. ?? 2006 East African Wild Life Society.

  17. Den use by arctic foxes (Alopex lagopus) in a subarctic region of western Alaska

    USGS Publications Warehouse

    Anthony, R. Michael

    1996-01-01

    Distribution, abundance, and use of arctic fox dens located in coastal tundra communities of the Yukon–Kuskokwim delta were determined in studies from 1985 to 1990. Dens were denser and less complex than those described in studies conducted above the Arctic Circle. Eighty-three dens of varying complexity were found in the 52-km2 study area. Nineteen dens were used by arctic foxes for whelping or rearing pups. Three females relocated litters to multiple dens; a maximum of four dens were used concurrently by pups from one litter. Although red foxes (Vulpes vulpes) were common in the region, their use of dens in the study area was minimal. Differences in vegetation at den sites and nearby unoccupied sites were minimal. Furthermore, den sites could not be distinguished from non-den sites during aerial surveys.

  18. Denning chronology and design of effective bear management units

    USGS Publications Warehouse

    Inman, R.M.; Costello, C.M.; Jones, D.E.; Inman, K.H.; Thompson, B.C.; Quigley, H.B.

    2007-01-01

    Reports on the effectiveness of using late fall hunting seasons to reduce the proportion of female black bears (Ursus americanus) in the harvest are limited, and the geographic scale over which the technique functions as intended has not been examined. During 1992-2000, we radio-equipped black bears in New Mexico, USA, obtained estimates of 175 den entry and 137 den emergence dates, and used New Mexico Department of Game and Fish harvest data (1985-2000) to test for differences in proportion of females in the harvest relative to denning chronology. Bears in northern New Mexico entered dens earlier and emerged later than bears in southern New Mexico (P ??? 0.001). In northern New Mexico bears displayed the typical pattern of earlier entry and later emergence by reproductive females, proportion of females in the harvest varied over time as expected, and late fall seasons were effective (P ??? 0.10). In contrast, denning chronology did not differ by sex in southern New Mexico, proportion of females in the harvest did not change over time, and late fall seasons were not effective (P ??? 0.18). Manipulation of hunting season dates to influence female mortality can be an effective tool, however our study provides an example of an area where denning chronology did not differ by sex and late seasons were not effective. We also observed regional differences in timing of entrance and emergence, which suggest that scale of application may be key. In management jurisdictions that encompass ecologically distinct areas, cover a wide range of latitudes, or are mountainous, successful use of the technique may depend on knowledge of denning chronology at multiple locations and appropriate designation of hunting unit boundaries, season dates, and data analysis units.

  19. Remote identification of polar bear maternal den habitat in northern Alaska

    USGS Publications Warehouse

    Durner, G.M.; Amstrup, Steven C.; Ambrosius, Ken J.

    2001-01-01

    Polar bears (Ursus maritimus) give birth in dens of ice and snow to protect their altricial young. During the snow-free season, we visited 25 den sites located previously by radiotelemetry and characterized the den site physiognomy. Seven dens occurred in habitats with minimal relief. Eighteen dens (72%) were in coastal and river banks. These "banks" were identifiable on aerial photographs. We then searched high-resolution aerial photographs (n = 3000) for habitats similar to those of the 18 dens. On aerial photos, we mapped 1782 km of bank habitats suitable for denning. Bank habitats comprised 0.18% of our study area between the Colville River and the Tamayariak River in northern Alaska. The final map, which correctly identified 88% of bank denning habitat in this region, will help minimize the potential for disruptions of maternal dens by winter petroleum exploration activities.

  20. Detecting denning polar bears with Forward-Looking Infrared (FLIR) imagery

    USGS Publications Warehouse

    Amstrup, Steven C.; York, G.; McDonald, T.L.; Nielson, R.; Simac, K.

    2004-01-01

    Polar bears give birth in snow dens in midwinter and remain in dens until early spring. The survival and development of cubs is dependent on a stable environment within the maternal den. To mitigate potential disruption of polar bear denning by existing and proposed petroleum activities, we used forward-looking infrared (FLIR) viewing to try to detect heat rising from dens.We flew transects over dens of radio-collared females with FLIR imager-equipped aircraft, recorded weather conditions at each observation, and noted whether the den was detected.We surveyed 23 dens on 67 occasions (1 to 7 times each). Nine dens were always detected, and 10 dens visited more than once were detected on some flights but not on others. Four dens were never detected (17 percent), but three of those were visited only under marginal conditions. The odds of detecting a den were 4.8 times greater when airborne moisture (snow, blowing snow, fog, etc.) was absent than when it was present, and they increased 3-fold for every 1?C increase in temperature-dew point spread. The estimated probability of detecting dens in sunlight was 0. Data suggested that FLIR surveys conducted during optimal conditions for detection can produce detection rates approaching 90 percent and thus can be an important management and mitigation tool. polar bear, infrared imagery, maternal denning, human impacts, management

  1. American black bear denning behavior: Observations and applications using remote photography

    USGS Publications Warehouse

    Bridges, A.S.; Fox, J.A.; Olfenbuttel, C.; Vaughan, M.B.

    2004-01-01

    Researchers examining American black bear (Ursus americanus) denning behavior have relied primarily on den-site visitation and radiotelemetry to gather data. Repeated den-site visits are time-intensive and may disturb denning bears, possibly causing den abandonment, whereas radiotelemetry is sufficient only to provide gross data on den emergence. We used remote cameras to examine black bear denning behavior in the Allegheny Mountains of western Virginia during March-May 2003. We deployed cameras at 10 den sites and used 137 pictures of black bears. Adult female black bears exhibited greater extra-den activity than we expected prior to final den emergence, which occurred between April 12 and May 6, 2003. Our technique provided more accurate den-emergence estimation than previously published methodologies. Additionally, we observed seldom-documented behaviors associated with den exits and estimated cub age at den emergence. Remote cameras can provide unique insights into denning ecology, and we describe their potential application to reproductive, survival, and behavioral research.

  2. Habitat characteristics of polar bear terrestrial maternal den sites in northern Alaska

    USGS Publications Warehouse

    Durner, G.M.; Amstrup, Steven C.; Fischbach, Anthony S.

    2003-01-01

    Polar bears (Ursus maritimus) give birth to and nurture their young in dens of ice and snow. During 1999-2001, we measured the structure of 22 dens on the coastal plain of northern Alaska after polar bear families had evacuated their dens in the spring. During the summers of 2001 and 2002, we revisited the sites of 42 maternal and autumn exploratory dens and recorded characteristics of the under-snow habitat. The structure of polar bear snow dens was highly variable. Most were simple chambers with a single entrance/egress tunnel. Others had multiple chambers and additional tunnels. Thickness of snow above and below dens was highly variable, but most dens were overlain by less than 1 m of snow. Dens were located on, or associated with, pronounced landscape features (primarily coastal and river banks, but also a lake shore and an abandoned oil field gravel pad) that are readily distinguished from the surrounding terrain in summer and catch snow in early winter. Although easily identified, den landforms in northern Alaska were more subtle than den habitats in many other parts of the Arctic. The structure of polar bear dens in Alaska was strikingly similar to that of dens elsewhere and has remained largely unchanged in northern Alaska for more than 25 years. Knowledge of den structure and site characteristics will allow resource managers to identify habitats with the greatest probability of holding dens. This information may assist resource managers in preventing negative impacts of mineral exploration and extraction on polar bears.

  3. Denning habits of free-ranging dogs reveal preference for human proximity

    PubMed Central

    Sen Majumder, Sreejani; Paul, Manabi; Sau, Shubhra; Bhadra, Anindita

    2016-01-01

    Dens are crucial in the early development of many mammals, making den site selection an important component of parental care in such species. Resource availability and shelter from predators primarily govern den selection. Species inhabiting human-dominated landscapes typically den away from human disturbance, often shifting dens to avoid humans during the early life of their young. Domesticated dogs have evolved in human proximity over centuries, being bred and reared in human homes for generations. While pets rely on their owners for shelter and care, free-ranging dogs roam uncared, and typically whelp in dens. We conducted a study on 148 free-ranging dog dens in India to understand their denning habits. Distance from resources influenced den choice, but anthropogenic disturbance did not. Dens were found in areas of high human activity, and begging from humans was preferred over scavenging. A study on 15 pregnant females revealed that females actively searched for denning sites, rejecting several intermediate ones before selecting the final den. We propose that the obvious preference of dogs for denning close to humans is a behavioural adaptation that helps them to survive in the urban landscape, in spite of the high human induced mortality during the early life of pups. PMID:27535214

  4. Endodontic management of dens invaginatus Type IIIb: Case series

    PubMed Central

    Martins, Jorge N. R.; da Costa, Rui Pereira; Anderson, Craig; Quaresma, Sérgio André; Corte-Real, Luís S. M.; Monroe, Adam D.

    2016-01-01

    Dens invaginatus may be seen as a developmental malformation. It is characterized by an invagination of the enamel and dentin, creating a lumen inside the affected tooth, which may extend as deep as the apical foramen. Oehlers Type IIIb is considered the most challenging clinical conditions. The purpose of this study is to discuss the nonsurgical endodontic management of vital and necrotic dens invaginatus Type IIIb cases. Due to the complex anatomical consideration of dens invaginatus Type IIIb, endodontic treatment is extremely technique sensitive. A conservative approach was used in a vital case to treat the invaginated lumen only, to preserve the vitality of the pulp, and a more invasive approach was used in a necrotic case to debride the lumen and necrotic pulp for proper disinfection of the root canal system. Although different, all the approaches were successful. The clinical signs and symptoms were resolved. The vital case remains vital after 19 months, and the recall radiographs were able to show satisfactory periapical healing both in vital and necrotic cases. Due to the highly complex anatomy of dens invaginatus Type IIIb, the decision of preserving the pulp vitality may not be related only to pulpal diagnosis but also to the technical requirements of the treatment. Although very technically sensitive, it may be possible to treat the invaginated lumen exclusively, while preserving the vitality of the pulp. Necrotic cases may require a more aggressive approach to achieve a favorable prognosis. PMID:28042276

  5. Den-site characteristics of black bears in Rocky Mountain National Park, Colorado

    USGS Publications Warehouse

    Baldwin, R.A.; Bender, L.C.

    2008-01-01

    We compared historic (1985-1992) and contemporary (2003-2006) black bear (Ursus americanus) den locations in Rocky Mountain National Park (RMNP), Colorado, USA, for habitat and physiographic attributes of den sites and used maximum entropy modeling to determine which factors were most influential in predicting den-site locations. We observed variability in the relationship between den locations and distance to trails and elevation over rime. Locations of historic den sites were most associated with slope, elevation, and covertype, whereas contemporary sites were associated with slope, distance to roads, aspect, and canopy height. Although relationships to covariates differed between historic and contemporary periods, preferred den-site characteristics consistently included steep slopes and factors associated with greater snow depth. Distribution of den locations shifted toward areas closer to human developments, indicating little negative influence of this factor on den-site selection by black bears in RMNP.

  6. Selection of den sites by black bears in the southern Appalachians

    USGS Publications Warehouse

    Reynolds-Hogland, M. J.; Mitchell, M.S.; Powell, R.A.; Brown, D.C.

    2007-01-01

    We evaluated selection of den sites by American black bears (Ursus americanus) in the Pisgah Bear Sanctuary, western North Carolina, by comparing characteristics of dens at 53 den sites with availability of habitat characteristics in annual home ranges of bears and in the study area. We also tested whether den-site selection differed by sex, age, and reproductive status of bears. In addition, we evaluated whether the den component of an existing habitat model for black bears predicted where bears would select den sites. We found bears selected den sites far from gravel roads, on steep slopes, and at high elevations relative to what was available in both annual home ranges and in the study area. Den-site selection did not differ by sex or age, but it differed by reproductive status. Adult females with cubs preferred to den in areas that were relatively far from gravel roads, but adult females without cubs did not. The habitat model overestimated the value of areas near gravel roads, underestimated the value of moderately steep areas, and did not include elevation as a predictor variable. Our results highlight the importance of evaluating den selection in terms of both use and availability of den characteristics. ?? 2007 American Society of Mammalogists.

  7. A female black bear denning habitat model using a geographic information system

    USGS Publications Warehouse

    Clark, J.D.; Hayes, S.G.; Pledger, J.M.

    1998-01-01

    We used the Mahalanobis distance statistic and a raster geographic information system (GIS) to model potential black bear (Ursus americanus) denning habitat in the Ouachita Mountains of Arkansas. The Mahalanobis distance statistic was used to represent the standard squared distance between sample variates in the GIS database (forest cover type, elevation, slope, aspect, distance to streams, distance to roads, and forest cover richness) and variates at known bear dens. Two models were developed: a generalized model for all den locations and another specific to dens in rock cavities. Differences between habitat at den sites and habitat across the study area were represented in 2 new GIS themes as Mahalanobis distance values. Cells similar to the mean vector derived from the known dens had low Mahalanobis distance values, and dissimilar cells had high values. The reliability of the predictive model was tested by overlaying den locations collected subsequent to original model development on the resultant den habitat themes. Although the generalized model demonstrated poor reliability, the model specific to rock dens had good reliability. Bears were more likely to choose rock den locations with low Mahalanobis distance values and less likely to choose those with high values. The model can be used to plan the timing and extent of management actions (e.g., road building, prescribed fire, timber harvest) most appropriate for those sites with high or low denning potential. 

  8. Raccoon (Procyon lotor) diurnal den use within an intensively managed forest in central West Virginia

    USGS Publications Warehouse

    Owen, Sheldon F.; Berl, Jacob L.; Edwards, John W.; Ford, W. Mark; Wood, Petra Bohall

    2015-01-01

    Intensive forest management may influence the availability of suitable den sites for large den-seeking species, such as Procyon lotor (Raccoon). As part of a Raccoon ecology study on an industrial forest in the Allegheny Mountains of central West Virginia, we radio-tracked 32 Raccoons to 175 diurnal den sites to determine relative use of dens that included cavity trees, rock dens, log piles, slash piles, and exposed limbs. Patterns of den use significantly differed between sexes and among seasons. Overall, we recorded 58 cavity dens in 12 tree species with 7 maternal dens found in 5 tree species. Raccoons selected larger-diameter den trees than available cavity trees and non-cavity trees. Because the abundance of suitable tree cavities is known to influence Raccoon densities and recruitment at fine spatial scales and female Raccoons in this study used tree cavities as maternal den sites, the continued harvest of large-diameter trees (i.e., those capable of developing den cavities) without replacement may impact Raccoon recruitment within intensively managed forests throughout the central Appalachians.

  9. Landward and eastward shift of Alaskan polar bear denning associated with recent sea ice changes

    USGS Publications Warehouse

    Fischbach, A.S.; Amstrup, Steven C.; Douglas, D.C.

    2007-01-01

    Polar bears (Ursus maritimus) in the northern Alaska region den in coastal areas and on offshore drifting ice. We evaluated changes in the distribution of polar bear maternal dens between 1985 and 2005, using satellite telemetry. We determined the distribution of maternal dens occupied by 89 satellite collared female polar bears between 137°W and 167°W longitude. The proportion of dens on pack ice declined from 62% in 1985–1994 to 37% in 1998–2004 (P = 0.044) and among pack ice dens fewer occurred in the western Beaufort Sea after 1998. We evaluated whether hunting, attraction to bowhead whale remains, or changes in sea ice could explain changes in den distribution. We concluded that denning distribution changed in response to reductions in stable old ice, increases in unconsolidated ice, and lengthening of the melt season. In consort, these changes have likely reduced the availability and quality of pack ice denning habitat. Further declines in sea ice availability are predicted. Therefore, we expect the proportion of polar bears denning in coastal areas will continue to increase, until such time as the autumn ice retreats far enough from shore that it precludes offshore pregnant females from reaching the Alaska coast in advance of denning.

  10. Structure and Functional Studies of DEN-2 Virus Genome.

    DTIC Science & Technology

    1982-09-01

    Structure and Functional Studies on Dengue -2 Progress Report Virus Genome 1 Mar 82 - I Sep 82 6. PERFORMING ORO. REPORT NUMBER 7. AUTHOR(e) 8. CONTRACT OR...Identify by block number) Complementdry DNA synthesis of Dengue -2 RNA by avian reverse transcriptase in vitro. The size of the DNA copy of Dengue RNA is in...Unannounced 0 Justification ............ By........... Di.A b-Aio: i Availability Codes S Avail and (or 2 Abstract 1. Dengue -2 RNA (DEN-2 RNA) was extracted

  11. Nonlinear generalization of Den Hartog's equal-peak method

    NASA Astrophysics Data System (ADS)

    Habib, G.; Detroux, T.; Viguié, R.; Kerschen, G.

    2015-02-01

    This study addresses the mitigation of a nonlinear resonance of a mechanical system. In view of the narrow bandwidth of the classical linear tuned vibration absorber, a nonlinear absorber, termed the nonlinear tuned vibration absorber (NLTVA), is introduced in this paper. An unconventional aspect of the NLTVA is that the mathematical form of its restoring force is tailored according to the nonlinear restoring force of the primary system. The NLTVA parameters are then determined using a nonlinear generalization of Den Hartog's equal-peak method. The mitigation of the resonant vibrations of a Duffing oscillator is considered to illustrate the proposed developments.

  12. Einsteins Spuren in den Archiven der Wissenschaft: Physikgeschichte

    NASA Astrophysics Data System (ADS)

    Marx, Werner

    2005-07-01

    Die Erwähnungen und Zitierungen von Einsteins Arbeiten dokumentieren lediglich den quantifizierbaren Anteil von Einsteins Beitrag zur Physik. Gleichwohl belegen sie die außergewöhnliche Resonanz und Langzeitwirkung seiner Arbeiten. Die Häufigkeit der Zitierungen entspricht nicht der allgemeinen Einschätzung ihrer Bedeutung. Insbesondere die Pionierarbeiten werden inzwischen als bekannt vorausgesetzt und nicht mehr explizit zitiert. Interessanterweise ist seine nach 1945 meist zitierte Arbeit nicht eine der Pionierarbeiten zur Quantenphysik oder Relativitätstheorie, sondern jene aus dem Jahr 1935 zum berühmten Einstein-Podolsky-Rosen-Paradoxon.

  13. Post-den emergence behavior of polar bears (Ursus maritimus) in Northern Alaska

    USGS Publications Warehouse

    Smith, T.S.; Partridge, Steven T.; Amstrup, Steven C.; Schliebe, S.

    2007-01-01

    We observed polar bear (Ursus maritimus) maternity den sites on Alaska’s North Slope in March 2002 and 2003 in an effort to describe bears’ post-den emergence behavior. During 40 sessions spanning 459 h, we observed 8 adults and 14 dependent cubs outside dens for 37.5 h (8.2% of total observation time). There was no significant difference between den emergence dates in 2002 (mean = 15 Mar ± 4.1 d) and 2003 (mean = 21 Mar ± 2.1 d). Following initial den breakout, polar bears remained at their den sites for 1.5 to 14 days (mean = 8.1 ± 5.1 d). The average length of stay in dens between emergent periods was significantly shorter in 2002 (1.79 h) than in 2003 (4.82 h). While outside, adult bears were inactive 49.5% of the time, whereas cubs were inactive 13.4% of the time. We found no significant relationships between den emergence activity and weather. Adult polar bears at den sites subjected to industrial activity exhibited significantly fewer bouts of vigilance than denned bears in undisturbed areas (t = -5.5164, df = 4, p= 0.00). However, the duration of vigilance behaviors at sites near industrial activity was not significantly shorter than at the other sites studied (t = -1.8902, df = 4, p = 0.07). Results for these bears were within the range of findings in other studies of denned polar bears.

  14. Kin selection in den sharing develops under limited availability of tree hollows for a forest marsupial

    PubMed Central

    Banks, Sam C.; Lindenmayer, David B.; McBurney, Lachlan; Blair, David; Knight, Emma J.; Blyton, Michaela D. J.

    2011-01-01

    Animal social behaviour is not static with regard to environmental change. Flexibility in cooperative resource use may be an important response to resource decline, mediating the impacts of resource availability on fitness and demography. In forest ecosystems, hollow trees are key den resources for many species, but are declining worldwide owing to forestry. Altered patterns of den sharing may mediate the effects of the decline of this resource. We studied den-sharing interactions among hollow-dependent Australian mountain brushtail possums to investigate how spatial variation in hollow tree availability affects resource sharing and kin selection. Under reduced den availability, individuals used fewer dens and shared them less often. This suggests increased territoriality in the presence of resource competition. Further, there was a switch from kin avoidance to kin preference with decreasing hollow tree availability. This was driven primarily by a change in den sharing among siblings. The inclusive fitness benefits of den sharing with kin are likely to increase under resource-limiting conditions, but are potentially outweighed by the benefits of associating with non-relatives (avoidance of inbreeding or pathogen transmission) where dens are abundant. We discuss how predictions from social evolutionary theory can contribute to understanding animal responses to landscape change. PMID:21288953

  15. Polar bear maternal den habitat in the Arctic National Wildlife Refuge, Alaska

    USGS Publications Warehouse

    Durner, George M.; Amstrup, Steven C.; Ambrosius, Ken J.

    2006-01-01

    Polar bears (Ursus maritimus) give birth during mid-winter in dens of ice and snow. Denning polar bears subjected to human disturbances may abandon dens before their altricial young can survive the rigors of the Arctic winter. Because the Arctic coastal plain of Alaska is an area of high petroleum potential and contains existing and planned oil field developments, the distribution of polar bear dens on the plain is of interest to land managers. Therefore, as part of a study of denning habitats along the entire Arctic coast of Alaska, we examined high-resolution aerial photographs (n = 1655) of the 7994 km2 coastal plain included in the Arctic National Wildlife Refuge (ANWR) and mapped 3621 km of bank habitat suitable for denning by polar bears. Such habitats were distributed uniformly and comprised 0.29% (23.2 km2) of the coastal plain between the Canning River and the Canadian border. Ground-truth sampling suggested that we had correctly identified 91.5% of bank denning habitats on the ANWR coastal plain. Knowledge of the distribution of these habitats will help facilitate informed management of human activities and minimize disruption of polar bears in maternal dens.

  16. Den site activity patterns of adult male and female swift foxes, Vulpes velox, in Northwestern Texas

    USGS Publications Warehouse

    Lemons, P.R.; Ballard, W.B.; Sullivan, R.M.; Sovada, M.A.

    2003-01-01

    Activity of Swift Foxes (Vulpes velox) at den sites was studied in northwestern Texas during pup rearing seasons in 2000 and 2001 to determine role of males in parental care. Twenty-four percent of radio-collared females with a potential to breed successfully raised pups to eight weeks of age. We intensively monitored presence and absence of male and female Swift Foxes at two den sites each year. Females were present >2.6 times more at den sites than males during the pup rearing season. Female and male Swift Foxes largely stayed at dens during diurnal hours and were active away from dens during nocturnal and crepuscular hours. Females and males spent 12.4% and 3.0% more time at dens before pups emerged, than after pups emerged, respectively. Following depredation of one male parent, the female spent 29% less time at the den site. Decrease in time spent at the den by the female following loss of her mate suggested that loss of one parent might severely impact recruitment of Swift Foxes. Our observations indicated that intense Coyote (Canis latrans) depredation may severely impact pup-rearing success as well as the parental care within Swift Fox family groups.

  17. The Dens: A Review of its Diverse Nomenclature and a Recommended Simplified Terminology.

    PubMed

    Johal, Jaspreet; Fisahn, Christian; Burgess, Brittni; Loukas, Marios; Chapman, Jens; Oskouian, Rod J; Tubbs, R Shane

    2017-01-17

    Pathology of the dens, such as fractures, demands precise terminology so that communication between physicians are succinct, diagnoses are accurate, and treatment strategies exact. This review aims to summarize the various terms used to describe the parts of the dens and recommend the ideal terminology. Using standard search engines, English language publications were searched for the many terms used to describe parts of the dens. A multitude of terms was identified with many demonstrating overlaps. Terms identified included apex, tip, apicodental, subdental, dentocentral and odontocentral junctions, peg, waist, base, neck, shaft, shoulder, and stem. Exact terminology is necessary when diagnosing or treating patients with pathology of or near the dens. The authors suggest simplified terminology for describing the parts of the dens that can be used in the future in order to be unequivocal and to avoid confusion when classifying and communicating fractures through its parts.

  18. The Dens: A Review of its Diverse Nomenclature and a Recommended Simplified Terminology

    PubMed Central

    Johal, Jaspreet; Burgess, Brittni; Loukas, Marios; Chapman, Jens; Oskouian, Rod J; Tubbs, R. Shane

    2017-01-01

    Pathology of the dens, such as fractures, demands precise terminology so that communication between physicians are succinct, diagnoses are accurate, and treatment strategies exact. This review aims to summarize the various terms used to describe the parts of the dens and recommend the ideal terminology. Using standard search engines, English language publications were searched for the many terms used to describe parts of the dens. A multitude of terms was identified with many demonstrating overlaps. Terms identified included apex, tip, apicodental, subdental, dentocentral and odontocentral junctions, peg, waist, base, neck, shaft, shoulder, and stem. Exact terminology is necessary when diagnosing or treating patients with pathology of or near the dens. The authors suggest simplified terminology for describing the parts of the dens that can be used in the future in order to be unequivocal and to avoid confusion when classifying and communicating fractures through its parts. PMID:28229029

  19. Habitat, soils, and den use of San Joaquin kit fox (Vulpes velox macrotis) at Camp Roberts Army National Guard Training Site, California

    SciTech Connect

    Reese, E.A.; Standley, W.G.; Berry, W.H.

    1992-09-01

    Den use patterns, den characteristics, and effects of military training on dens were studied for San Joaquin kit foxes (Vulpes velox macrotis) at Camp Roberts Army National Guard Training Site, California.Ninety-four radiocollared kit foxes used 1059 dens and 334 buildings as shelter from December 1988, through September 1991. There were 1001 (95%) earthen dens, 57 (5%) culverts, and one den in a hollow log. Denentrance dimensions were measured for single entrance dens; the average height was 20 cm, and the average width was 21 cm. Most dens had two to five den entrances, and only 36% of dens found showed sign of fox activity. Dens were found at elevations between 161 and 351 m. The average slope of dens found on hillsides was 19 degrees, and most dens faced the western quadrant. Dens were found over much of the post exceptthe steep southwest portion. More kit fox dens were located in grassland and low to medium density oak woodlands than expected, and fewer dens were located in developed areas and medium to high density oak woodlands than expected. Denning range size was calculated for 16 foxes that were radiocollared at least one year and that were found using only earthen and culvert dens. The average denning range size was 171.0 [plus minus] 24.0 ha. There was no significant difference in male and female average denning range sizes. When buildings used as shelter were included in denning range sizes, there was no significant difference in average denning range size between developed and undeveloped areas. Foxes used 26 of 36 available soil series, and dens were not distributed proportionally among the 36 soil series. Kit fox dens were typically found in well drained soils. Few den entrances were destroyed by military training exercises.

  20. Habitat, soils, and den use of San Joaquin kit fox (Vulpes velox macrotis) at Camp Roberts Army National Guard Training Site, California

    SciTech Connect

    Reese, E.A.; Standley, W.G.; Berry, W.H.

    1992-09-01

    Den use patterns, den characteristics, and effects of military training on dens were studied for San Joaquin kit foxes (Vulpes velox macrotis) at Camp Roberts Army National Guard Training Site, California.Ninety-four radiocollared kit foxes used 1059 dens and 334 buildings as shelter from December 1988, through September 1991. There were 1001 (95%) earthen dens, 57 (5%) culverts, and one den in a hollow log. Denentrance dimensions were measured for single entrance dens; the average height was 20 cm, and the average width was 21 cm. Most dens had two to five den entrances, and only 36% of dens found showed sign of fox activity. Dens were found at elevations between 161 and 351 m. The average slope of dens found on hillsides was 19 degrees, and most dens faced the western quadrant. Dens were found over much of the post exceptthe steep southwest portion. More kit fox dens were located in grassland and low to medium density oak woodlands than expected, and fewer dens were located in developed areas and medium to high density oak woodlands than expected. Denning range size was calculated for 16 foxes that were radiocollared at least one year and that were found using only earthen and culvert dens. The average denning range size was 171.0 {plus_minus} 24.0 ha. There was no significant difference in male and female average denning range sizes. When buildings used as shelter were included in denning range sizes, there was no significant difference in average denning range size between developed and undeveloped areas. Foxes used 26 of 36 available soil series, and dens were not distributed proportionally among the 36 soil series. Kit fox dens were typically found in well drained soils. Few den entrances were destroyed by military training exercises.

  1. Vector competence of Aedes albopictus and Aedes aegypti (Diptera: Culicidae) for the DEN2-FJ10 and DEN2-FJ11 strains of the dengue 2 virus in Fujian, China.

    PubMed

    Guo, Xiao-Xia; Li, Chun-Xiao; Zhang, Ying-Mei; Xing, Dan; Dong, Yan-De; Zhang, Heng-Duan; Qin, Cheng-Feng; Zhao, Tong-Yan

    2016-09-01

    Dengue is an acute, emerging, infectious disease transmitted by Aedes mosquitoes that has become a serious global public health problem. The DEN2-FJ10 and DEN2-FJ11 strains of the dengue 2 virus were originally isolated from the serum of a patient with dengue fever in Fujian Province, China, in 1999. Our data provide the first assessment of the vector competence of Aedes mosquitoes with respect to the DEN2-FJ10 and DEN2-FJ11 strains of the dengue virus. There were significant differences in the replication rates of these two viral strains in Aedes albopictus and Aedes aegypti (P<0.05); replication of the DEN2-FJ10 strain was greater in Ae. aegypti than in Ae. albopictus 5 days post infection whereas replication of the DEN2-FJ11 was greater in Ae. albopictus than in Ae. aegypti 7 days post infection. The replicative ability of the DEN2-FJ11 strain was greater than that of the DEN2-FJ10 strain in infected Ae. albopictus. In infected Ae. aegypti, rapid proliferation of the DEN2-FJ10 strain occurred earlier than in the DEN2-FJ11 strain. There were no significant differences in the midgut and salivary gland infection rates of Ae. albopictus and Ae. aegypti with respect to either viral strain. Although the DEN2-FJ10 and DEN2-FJ11 strains differ in their virulence to neonatal rats, there was no significant difference in the ability of either Ae. albopictus or Ae. aegypti to transmit the DEN2-FJ10 and DEN2-FJ10 strains of the dengue 2 virus (P>0.05). In summary, our results indicate that Ae. albopictus and Ae. aegypti mosquitoes are moderately competent vectors of the DEN2-FJ10 and DEN2-FJ11 strains of the dengue virus and provide the first evidence of the effect of these two viral strains on the vector competence of mosquitoes in China.

  2. Hibernacula and summer den sites of pine snakes (Pituophis melanoleucus) in the New Jersey pine barrens

    USGS Publications Warehouse

    Burger, J.; Zappalorti, R.T.; Gochfeld, M.; Boarman, W.I.; Caffrey, M.; Doig, V.; Garber, S.D.; Lauro, B.; Mikovsky, M.; Safina, C.; Saliva, Jorge

    1988-01-01

    We examined eight summer dens (used only in summer) and seven hibernacula (occupied both in winter and summer) of the snake Pituophis melanoleucus in the New Jersey Pine Barrens, comparing above ground characteristics of hibernacula and summer dens with characteristics at nearby random points. Temperatures at the soil surface and at 10 cm depth were significantly warmer, and there was less leaf cover around the random points compared to the entrances of the hibernacula and summer dens. Hibernacula had significantly more vegetation cover within 5 m, more leaf cover over the burrow entrance, and were closer to trees than were summer dens. Most hibernacula and summer dens were beside old fallen logs (73%), the entrance tunnels following decaying roots into the soil. Excavation of the hibernacula and summer dens indicated that most hibernacula appeared to be dug by the snakes and had an average of eight side chambers and 642 cm of tunnels, compared to less than one side chamber and 122 cm of tunnels for summer dens. Except for hatchlings, most snakes in hibernacula were located in individual chambers off the main tunnel; all snakes were at depths of 50-111 cm (X̄ = 79 cm). Pine snakes may select optimum hibernation sites which reduce winter mortality.

  3. Den Entry Behavior in Scandinavian Brown Bears: Implications for Preventing Human Injuries

    PubMed Central

    Sahlén, Veronica; Friebe, Andrea; Sæbø, Solve; Swenson, Jon E; Støen, Ole-Gunnar

    2015-01-01

    Encounters between Scandinavian brown bears (Ursus arctos) and humans that result in human injuries and fatalities typically coincide with den entry in October and November, and commonly occur near a den. Our aim was to determine when bears arrive at their dens, identify potential predictors of this event, document behavior and activity associated with this period, and attempt to explain the increased risk of bear-caused human injuries in this period. We analyzed global positioning system (GPS) location and activity data from brown bears in south-central Sweden, using generalized linear mixed models, statistical process control, and activity analyses. Bears arrived at their den sites between 6 October and 1 December. Timing varied by reproductive category, bear age, and year. Half of all bears significantly reduced their activity before arriving at the den area: on average 2,169 m away from the den and 1.8 days before arrival. The other half reduced their activity after arriving at the den area. The latter bears took longer time to reach hibernation activity levels, but we did not find a difference in the start date of hibernation between the 2 groups. Bears also appeared to be sensitive to disturbance in this period, with higher den abandonment rates than later in winter, particularly for males and for bears that had not visited their den sites previously. Den entry occurred from October to December, with high variability and poor predictability of its timing. Therefore, restricting hunting or other recreation activities to reduce risk of injury by bears and disturbing bears probably would be both impractical and ineffective. Our findings can be used to educate hunters about bear behavior at this time of year. Many people associate dens with an increased risk of a bear responding aggressively to disturbance to defend its den, but our results indicate that other behavioral, and possibly physiological, changes in this period also may be involved. © 2014 The

  4. Inducing G2/M Cell Cycle Arrest and Apoptosis through Generation Reactive Oxygen Species (ROS)-Mediated Mitochondria Pathway in HT-29 Cells by Dentatin (DEN) and Dentatin Incorporated in Hydroxypropyl-β-Cyclodextrin (DEN-HPβCD)

    PubMed Central

    Ashwaq, Al-Abboodi Shakir; Al-Qubaisi, Mothanna Sadiq; Rasedee, Abdullah; Abdul, Ahmad Bustamam; Taufiq-Yap, Yun Hin; Yeap, Swee Keong

    2016-01-01

    Dentatin (DEN), purified from the roots of Clausena excavata Burm f., has poor aqueous solubility that reduces its therapeutic application. The aim of this study was to assess the effects of DEN-HPβCD (hydroxypropyl-β-cyclodextrin) complex as an anticancer agent in HT29 cancer cell line and compare with a crystal DEN in dimethyl sulfoxide (DMSO). The exposure of the cancer cells to DEN or DEN-HPβCD complex leads to cell growth inhibition as determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. To analyze the mechanism, in which DEN or DEN-HPβCD complex causes the death in human colon HT29 cancer cells, was evaluated by the enzyme-linked immunosorbent assay (ELIZA)-based assays for caspase-3, 8, 9, and reactive oxygen species (ROS). The findings showed that an anti-proliferative effect of DEN or DEN-HPβCD complex were via cell cycle arrest at the G2/M phase and eventually induced apoptosis through both mitochondrial and extrinsic pathways. The down-regulation of poly(ADP-ribose) polymerase (PARP) which leaded to apoptosis upon treatment, was investigated by Western-blotting. Hence, complexation between DEN and HPβCD did not diminish or eliminate the effective properties of DEN as anticancer agent. Therefore, it would be possible to resolve the conventional and current issues associated with the development and commercialization of antineoplastic agents in the future. PMID:27763535

  5. Nonsurgical endodontic management of dens invaginatus with open apex: A case report

    PubMed Central

    Rani, Nidhi; Sroa, Renu B

    2015-01-01

    Dens invaginatus is a rare malformation with a widely varied morphology. It typically affects permanent maxillary lateral incisors, central incisors, and premolars. This article demonstrates rapid management of type II dens invagination with open apex and large periradicular lesion using calcium hydroxide as intracanal medicament for 1-week followed by apical plug formation with mineral trioxide aggregate Plus and lateral condensation of Gutta-percha. At 24-month follow-up, the patient was asymptomatic and lesion was entirely resolved. PMID:26751206

  6. Arctic foxes as ecosystem engineers: increased soil nutrients lead to increased plant productivity on fox dens.

    PubMed

    Gharajehdaghipour, Tazarve; Roth, James D; Fafard, Paul M; Markham, John H

    2016-04-05

    Top predators can provide fundamental ecosystem services such as nutrient cycling, and their impact can be even greater in environments with low nutrients and productivity, such as Arctic tundra. We estimated the effects of Arctic fox (Vulpes lagopus) denning on soil nutrient dynamics and vegetation production near Churchill, Manitoba in June and August 2014. Soils from fox dens contained higher nutrient levels in June (71% more inorganic nitrogen, 1195% more extractable phosphorous) and in August (242% more inorganic nitrogen, 191% more extractable phosphorous) than adjacent control sites. Inorganic nitrogen levels decreased from June to August on both dens and controls, whereas extractable phosphorous increased. Pup production the previous year, which should enhance nutrient deposition (from urine, feces, and decomposing prey), did not affect soil nutrient concentrations, suggesting the impact of Arctic foxes persists >1 year. Dens supported 2.8 times greater vegetation biomass in August, but δ(15)N values in sea lyme grass (Leymus mollis) were unaffected by denning. By concentrating nutrients on dens Arctic foxes enhance nutrient cycling as an ecosystem service and thus engineer Arctic ecosystems on local scales. The enhanced productivity in patches on the landscape could subsequently affect plant diversity and the dispersion of herbivores on the tundra.

  7. Arctic foxes as ecosystem engineers: increased soil nutrients lead to increased plant productivity on fox dens

    NASA Astrophysics Data System (ADS)

    Gharajehdaghipour, Tazarve; Roth, James D.; Fafard, Paul M.; Markham, John H.

    2016-04-01

    Top predators can provide fundamental ecosystem services such as nutrient cycling, and their impact can be even greater in environments with low nutrients and productivity, such as Arctic tundra. We estimated the effects of Arctic fox (Vulpes lagopus) denning on soil nutrient dynamics and vegetation production near Churchill, Manitoba in June and August 2014. Soils from fox dens contained higher nutrient levels in June (71% more inorganic nitrogen, 1195% more extractable phosphorous) and in August (242% more inorganic nitrogen, 191% more extractable phosphorous) than adjacent control sites. Inorganic nitrogen levels decreased from June to August on both dens and controls, whereas extractable phosphorous increased. Pup production the previous year, which should enhance nutrient deposition (from urine, feces, and decomposing prey), did not affect soil nutrient concentrations, suggesting the impact of Arctic foxes persists >1 year. Dens supported 2.8 times greater vegetation biomass in August, but δ15N values in sea lyme grass (Leymus mollis) were unaffected by denning. By concentrating nutrients on dens Arctic foxes enhance nutrient cycling as an ecosystem service and thus engineer Arctic ecosystems on local scales. The enhanced productivity in patches on the landscape could subsequently affect plant diversity and the dispersion of herbivores on the tundra.

  8. Arctic foxes as ecosystem engineers: increased soil nutrients lead to increased plant productivity on fox dens

    PubMed Central

    Gharajehdaghipour, Tazarve; Roth, James D.; Fafard, Paul M.; Markham, John H.

    2016-01-01

    Top predators can provide fundamental ecosystem services such as nutrient cycling, and their impact can be even greater in environments with low nutrients and productivity, such as Arctic tundra. We estimated the effects of Arctic fox (Vulpes lagopus) denning on soil nutrient dynamics and vegetation production near Churchill, Manitoba in June and August 2014. Soils from fox dens contained higher nutrient levels in June (71% more inorganic nitrogen, 1195% more extractable phosphorous) and in August (242% more inorganic nitrogen, 191% more extractable phosphorous) than adjacent control sites. Inorganic nitrogen levels decreased from June to August on both dens and controls, whereas extractable phosphorous increased. Pup production the previous year, which should enhance nutrient deposition (from urine, feces, and decomposing prey), did not affect soil nutrient concentrations, suggesting the impact of Arctic foxes persists >1 year. Dens supported 2.8 times greater vegetation biomass in August, but δ15N values in sea lyme grass (Leymus mollis) were unaffected by denning. By concentrating nutrients on dens Arctic foxes enhance nutrient cycling as an ecosystem service and thus engineer Arctic ecosystems on local scales. The enhanced productivity in patches on the landscape could subsequently affect plant diversity and the dispersion of herbivores on the tundra. PMID:27045973

  9. Remote identification of maternal polar bear (Ursus maritimus) denning habitat on the Colville River Delta, Alaska

    NASA Astrophysics Data System (ADS)

    Blank, Justin J.

    High resolution digital aerial photographs (1 foot pixel size) of the Colville River Delta, Alaska were examined in 3D, with the use of a digital photogrammetric workstation. Topographic features meeting the criteria required for adequate snow accumulation, and subsequent construction of terrestrial polar bear maternal dens, were identified and digitized into an ArcGIS line shapefile. Effectiveness, efficiency, and accuracy were improved when compared to previous polar bear denning habitat efforts which utilized contact photo prints and a pocket stereoscope in other geographic areas of northern Alaska. Accuracy of photograph interpretation was systematically evaluated visually from the air with the use of a helicopter and physically on the ground. Results show that the mapping efforts were successful in identifying den habitat 91.3% of the time. Knowledge denning habitat can improve and inform decision making by managers and regulators when considering travel and development in the study area. An understanding of polar bear denning habitat extent and location will be a crucial tool for planning activities within the study area in a way that minimizes conflicts with maternal dens.

  10. Despotism and risk of infanticide influence grizzly bear den-site selection.

    PubMed

    Libal, Nathan S; Belant, Jerrold L; Leopold, Bruce D; Wang, Guiming; Owen, Patricia A

    2011-01-01

    Given documented social dominance and intraspecific predation in bear populations, the ideal despotic distribution model and sex hypothesis of sexual segregation predict adult female grizzly bears (Ursus arctos) will avoid areas occupied by adult males to reduce risk of infanticide. Under ideal despotic distribution, juveniles should similarly avoid adult males to reduce predation risk. Den-site selection and use is an important component of grizzly bear ecology and may be influenced by multiple factors, including risk from conspecifics. To test the role of predation risk and the sex hypothesis of sexual segregation, we compared adult female (n = 142), adult male (n = 36), and juvenile (n = 35) den locations in Denali National Park and Preserve, Alaska, USA. We measured elevation, aspect, slope, and dominant land cover for each den site, and used maximum entropy modeling to determine which variables best predicted den sites. We identified the global model as the best-fitting model for adult female (area under curve (AUC) = 0.926) and elevation as the best predictive variable for adult male (AUC = 0.880) den sites. The model containing land cover and elevation best-predicted juvenile (AUC = 0.841) den sites. Adult females spatially segregated from adult males, with dens characterized by higher elevations (mean= 1,412 m, SE = 52) and steeper slopes (mean = 21.9°, SE = 1.1) than adult male (elevation: mean = 1,209 m, SE = 76; slope: mean = 15.6°, SE = 1.9) den sites. Juveniles used a broad range of landscape attributes but did not avoid adult male denning areas. Observed spatial segregation by adult females supports the sex hypothesis of sexual segregation and we suggest is a mechanism to reduce risk of infanticide. Den site selection of adult males is likely related to distribution of food resources during spring.

  11. Heading for the hills: risk avoidance drives den site selection in African wild dogs.

    PubMed

    Jackson, Craig R; Power, R John; Groom, Rosemary J; Masenga, Emmanuel H; Mjingo, Ernest E; Fyumagwa, Robert D; Røskaft, Eivin; Davies-Mostert, Harriet

    2014-01-01

    Compared to their main competitors, African wild dogs (Lycaon pictus) have inferior competitive abilities and interspecific competition is a serious fitness-limiting factor. Lions (Panthera leo) are the dominant large carnivore in African savannah ecosystems and wild dogs avoid them both spatially and temporally. Wild dog young are particularly vulnerable and suffer high rates of mortality from lions. Since lions do not utilize all parts of the landscape with an equal intensity, spatial variation in lion densities can be exploited by wild dogs both during their general ranging behaviour, but more specifically when they are confined to a den with vulnerable young. Since patches of rugged terrain are associated with lower lion densities, we hypothesized that these comparatively safe habitats should be selected by wild dogs for denning. We investigated the relationship between the distribution of 100 wild dog den sites and the occurrence of rugged terrain in four wild dog populations located in Tanzania, Zimbabwe and South Africa. A terrain ruggedness index was derived from a 90 m digital elevation model and used to map terrain ruggedness at each site. We compared characteristics of actual and potential (random) den sites to determine how wild dogs select den sites. The distributions of wild dog dens were strongly associated with rugged terrain and wild dogs actively selected terrain that was more rugged than that available on average. The likelihood of encountering lions is reduced in these habitats, minimizing the risk to both adults and pups. Our findings have important implications for the conservation management of the species, especially when assessing habitat suitability for potential reintroductions. The simple technique used to assess terrain ruggedness may be useful to investigate habitat suitability, and even predict highly suitable denning areas, across large landscapes.

  12. Nonsurgical endodontic treatment of a maxillary lateral incisor with dens invaginatus type II: A case report

    PubMed Central

    Shadmehr, Elham; Kiaani, Sima; Mahdavian, Parinaz

    2015-01-01

    Dens invaginatus is a rare developmental anomaly of teeth with complex root canal system morphology. The present case describes a peg shape maxillary lateral incisor with dens invaginatus (Oehlers type II), necrotic pulp, and an associated large periradicular lesion. Nonsurgical endodontic treatment was performed with the aim of removing the blind sac with diamond bur under the use of operating surgical microscope. The root canal system was obturated with thermoplastic technique. Final restoration was done using composite. The 20-months clinical and radiological follow up revealed an asymptomatic tooth with healing of the periapical pathology; however, for complete healed periradicular lesion more follow up is needed. This case illustrated that a dens invaginatus malformed teeth with a large periradicular lesion can be managed successfully with nonsurgical root canal therapy (NSRCT). PMID:25878686

  13. The Chimeric Protein Domain III-Capsid of Dengue Virus Serotype 2 (DEN-2) Successfully Boosts Neutralizing Antibodies Generated in Monkeys upon Infection with DEN-2▿

    PubMed Central

    Valdés, Iris; Gil, Lázaro; Romero, Yaremis; Castro, Jorge; Puente, Pedro; Lazo, Laura; Marcos, Ernesto; Guzmán, María G.; Guillén, Gerardo; Hermida, Lisset

    2011-01-01

    Use of a heterologous prime-boost strategy based on a combination of nonreplicative immunogens and candidate attenuated virus vaccines against dengue virus in the same schedule is an attractive approach. These combinations may result in a condensed immunization regime for humans, thus reducing the number of doses with attenuated virus and the time spacing. The present work deals with the evaluation of the heterologous prime-boost strategy combining a novel chimeric protein (domain III-capsid) of dengue virus serotype 2 (DEN-2) and the infective homologous virus in the same immunization schedule in monkeys. Primed monkeys received one dose of infective DEN-2 and were then vaccinated with the recombinant protein. We found that animals developed a neutralizing antibody response after the infective dose and were notably boosted with a second dose of the chimeric protein 3 months later. The neutralizing antibodies induced were long lasting, and animals also showed the ability to induce a specific cellular response 6 months after the booster dose. As a conclusion, we can state that the domain III region, when it is properly presented as a fusion protein to the immune system, is able to recall the neutralizing antibody response elicited following homologous virus infection in monkeys. Further prime-boost approaches can be performed in a condensed regime combining the chimeric domain III-capsid protein and candidate live attenuated vaccines against DEN-2. PMID:21209159

  14. Mapping polar bear maternal denning habitat in the National Petroleum Reserve -- Alaska with an IfSAR digital terrain model

    USGS Publications Warehouse

    Durner, George M.; Simac, Kristin; Amstrup, Steven C.

    2013-01-01

    The National Petroleum Reserve–Alaska (NPR-A) in northeastern Alaska provides winter maternal denning habitat for polar bears (Ursus maritimus) and also has high potential for recoverable hydrocarbons. Denning polar bears exposed to human activities may abandon their dens before their young are able to survive the severity of Arctic winter weather. To ensure that wintertime petroleum activities do not threaten polar bears, managers need to know the distribution of landscape features in which maternal dens are likely to occur. Here, we present a map of potential denning habitat within the NPR-A. We used a fine-grain digital elevation model derived from Interferometric Synthetic Aperture Radar (IfSAR) to generate a map of putative denning habitat. We then tested the map’s ability to identify polar bear denning habitat on the landscape. Our final map correctly identified 82% of denning habitat estimated to be within the NPR-A. Mapped denning habitat comprised 19.7 km2 (0.1% of the study area) and was widely dispersed. Though mapping denning habitat with IfSAR data was as effective as mapping with the photogrammetric methods used for other regions of the Alaskan Arctic coastal plain, the use of GIS to analyze IfSAR data allowed greater objectivity and flexibility with less manual labor. Analytical advantages and performance equivalent to that of manual cartographic methods suggest that the use of IfSAR data to identify polar bear maternal denning habitat is a better management tool in the NPR-A and wherever such data may be available.

  15. Identification of a dengue virus type 2 (DEN-2) serotype-specific B-cell epitope and detection of DEN-2-immunized animal serum samples using an epitope-based peptide antigen.

    PubMed

    Wu, Han-Chung; Jung, Mei-Ying; Chiu, Chien-Yu; Chao, Ting-Ting; Lai, Szu-Chia; Jan, Jia-Tsrong; Shaio, Men-Fang

    2003-10-01

    In this study, a serotype-specific monoclonal antibody (mAb), D(2) 16-1 (Ab4), against dengue virus type 2 (DEN-2) was generated. The specificity of Ab4, which recognized DEN-2 non-structural protein 1, was determined by ELISA, immunofluorescence and immunoblotting analyses. The serotype-specific B-cell epitope of Ab4 was identified further from a random phage-displayed peptide library; selected phage clones reacted specifically with Ab4 and did not react with other mAbs. Immunopositive phage clones displayed a consensus motif, His-Arg/Lys-Leu/Ile, and a synthetic peptide corresponding to the phage-displayed peptide bound specifically to Ab4. The His and Arg residues in this epitope were found to be crucial for peptide binding to Ab4 and binding activity decreased dramatically when these residues were changed to Leu. The epitope-based synthetic peptide not only identified serum samples from DEN-2-immunized mice and rabbits by ELISA but also differentiated clearly between serum samples from DEN-2- and Japanese encephalitis virus-immunized mice. This mAb and its epitope-based peptide antigen will be useful for serologic diagnosis of DEN-2 infection. Furthermore, DEN-2 epitope identification makes it feasible to dissect antibody responses to DEN and to address the role of antibodies in the pathogenesis of primary and secondary DEN-2 infections.

  16. Protective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver.

    PubMed

    Fukumasu, H; Avanzo, J L; Heidor, R; Silva, T C; Atroch, A; Moreno, F S; Dagli, M L Z

    2006-06-01

    Guarana (Paullinia cupana Mart. var. Sorbilis) is a plant originally from Brazil, which is rich in tannins. Some tannins are known to present protective effects against DNA damage. This study was performed to investigate the anti-genotoxic/cytotoxic properties of guarana in hepatocytes of mice injected with N-nitrosodiethylamine (DEN). The protective effect of guarana was evaluated both by comet assay and DNA smear fragmentation technique in two month-old female BALB/c mice. These were treated previously with 2.0 mg/g bw of guarana for 16 days and then injected with DEN (160 microg/g body weight) to induce DNA damage. The DEN-only treated group presented higher comet image length than the guarana plus DEN and untreated groups (116.06+/-5.0 microm, 104.09+/-3.3 microm and 93.28+/-14.4 microm, respectively; p<0.01). Guarana treatment presented a 52.54% reduction in comet image length when animals were exposed to DEN (p<0.05). DNA samples from the guarana plus DEN group clearly showed less EtBr fluorescence intensity when compared to the DEN-only group, reinforcing the comet assay data. These results show, for the first time, that guarana has a protective effect against DEN-induced DNA damage in mouse liver.

  17. First evidence of gregarious denning in opossums (Didelphimorphia, Didelphidae), with notes on their social behaviour.

    PubMed

    Astúa, Diego; Carvalho, Rafael A; Maia, Paula F; Magalhães, Arthur R; Loretto, Diogo

    2015-06-01

    The Didelphidae are considered solitary opossums with few social interactions, usually limited to mating-related or mother-pouch young interactions. Anecdotal reports suggest that additional interactions occur, including den sharing by a few individuals, usually siblings. Here, we report novel observations that indicate opossums are more social than previously thought. These include nest sharing by males and females of Marmosa paraguayana, Gracilinanus microtarsus and Marmosops incanus prior to the onset of the breeding season and without signs of sexual activity; this is taken to indicate early pair-bonding matching and cooperative nest building. We also recorded den sharing among recently weaned siblings of Didelphis aurita and Caluromys philander. In addition, we observed 13 individuals of Didelphis albiventris representing three age classes resting without agonistic interactions in a communal den. These are the first reports of gregarious behaviour involving so many individuals, which are either unrelated or represent siblings from at least two litters, already weaned, sharing the same den with three adults. Sociality in opossums is probably more complex than previously established, and field experimental designs combining the use of artificial nests with camera traps or telemetry may help to gauge the frequency and extent of these phenomena.

  18. Surgical Orthodontic Treatment of an Impacted Canine in the Presence of Dens Invaginatus and Follicular Cyst

    PubMed Central

    Canevello, Carola; Laffi, Nicola

    2014-01-01

    Introduction. “Dens invaginatus” is a dental anomaly which originates from the invagination of the ameloblastic epithelium into the lingual surface of the dental crown during the odontogenesis. It can cause early pulpal necrosis, abscesses, retention or dislocation of contiguous elements, cysts, and internal resorptions. It normally affects the upper lateral incisors. In the following study the authors will discuss the etiology, the physiopathology, and the surgical-orthodontic management of a rare case of impacted canine associated with dens invaginatus and follicular cyst, with the aim of highlighting the importance of taking any therapeutic decision based on the data available in the literature. Case Report. The present study describes a combined surgical-orthodontic treatment of an impacted canine associated with a lateral incisor (2.2) suffering from type III dens invaginatus with radicular cyst, in a 15-year-old patient. Discussion. When treating a dens invaginatus there are different therapeutic solutions: they depend on the gravity of the anomaly and on the association with the retention of a permanent tooth. The aesthetic and functional restoration becomes extremely important when performing a surgical-orthodontic repositioning. PMID:24963421

  19. First evidence of gregarious denning in opossums (Didelphimorphia, Didelphidae), with notes on their social behaviour

    PubMed Central

    Astúa, Diego; Carvalho, Rafael A.; Maia, Paula F.; Magalhães, Arthur R.; Loretto, Diogo

    2015-01-01

    The Didelphidae are considered solitary opossums with few social interactions, usually limited to mating-related or mother–pouch young interactions. Anecdotal reports suggest that additional interactions occur, including den sharing by a few individuals, usually siblings. Here, we report novel observations that indicate opossums are more social than previously thought. These include nest sharing by males and females of Marmosa paraguayana, Gracilinanus microtarsus and Marmosops incanus prior to the onset of the breeding season and without signs of sexual activity; this is taken to indicate early pair-bonding matching and cooperative nest building. We also recorded den sharing among recently weaned siblings of Didelphis aurita and Caluromys philander. In addition, we observed 13 individuals of Didelphis albiventris representing three age classes resting without agonistic interactions in a communal den. These are the first reports of gregarious behaviour involving so many individuals, which are either unrelated or represent siblings from at least two litters, already weaned, sharing the same den with three adults. Sociality in opossums is probably more complex than previously established, and field experimental designs combining the use of artificial nests with camera traps or telemetry may help to gauge the frequency and extent of these phenomena. PMID:26085500

  20. DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions

    PubMed Central

    Arjunan, Selvam; Sastri, Narayan P.; Chandra, Nagasuma

    2016-01-01

    Dengue virus (DENV) is a human pathogen and its etiology has been widely established. There are many interactions between DENV and human proteins that have been reported in literature. However, no publicly accessible resource for efficiently retrieving the information is yet available. In this study, we mined all publicly available dengue–human interactions that have been reported in the literature into a database called DenHunt. We retrieved 682 direct interactions of human proteins with dengue viral components, 382 indirect interactions and 4120 differentially expressed human genes in dengue infected cell lines and patients. We have illustrated the importance of DenHunt by mapping the dengue–human interactions on to the host interactome and observed that the virus targets multiple host functional complexes of important cellular processes such as metabolism, immune system and signaling pathways suggesting a potential role of these interactions in viral pathogenesis. We also observed that 7 percent of the dengue virus interacting human proteins are also associated with other infectious and non-infectious diseases. Finally, the understanding that comes from such analyses could be used to design better strategies to counteract the diseases caused by dengue virus. The whole dataset has been catalogued in a searchable database, called DenHunt (http://proline.biochem.iisc.ernet.in/DenHunt/). PMID:27618709

  1. First report of captive New Guinea dingo (Canis dingo hallstromi) den-digging and parental behavior.

    PubMed

    Koler-Matznick, Janice; Stinner, Mindy

    2011-01-01

    New Guinea dingoes (NGDs) (Canis dingo hallstromi; Troughton [1957] Proc Roy Soc new South Wells 1955-1956:93-94) have been kept in zoos since 1956. Almost nothing is known of their wild behavior. These observations of a captive pair are the first documentation of natal den-digging and parental behavior for this taxon. The main den, excavated near the top of a 1.5 m hill, consisted of a rounded chamber about 50.8 cm deep, with an entrance about 30.5 cm high and 40.6 cm wide. The dam frequently moved the pups from the natal den to secondary locations for short periods during the day and then back to the den, starting when the pups were 2 weeks old. When the pups were between 5 and 12 weeks of age, both parents regularly regurgitated for them. The sire expressed escalating threat behavior toward the male pup starting when the pup was 5 months old, and the female began threatening the female pups at about 6 months of age. Rejection of same-sex offspring is usual for captive NGDs as the next breeding season approaches.

  2. [Annual distribution and abundance of Ceratium dens (Peridinales: Ceratiaceae) in the Gulf of California, Mexico].

    PubMed

    Cortés Altamirano, R; Nuñez Pasten, A

    2000-01-01

    Ceratium dens distribution in the Gulf of California was studied based on three oceanographic campaigns, monthly abundance (1995-96) and during three red tide events in Mazatlán Bay. 52 phytoplankton samples with a Bongo net and 64 microns mesh light, during the year 120 water samples with a van Dorn bottle were collected in two sampling stations and from three red tide events. All samples were counted by the inverted-microscope method. The results showed that C. dens was present in the upper Gulf of California and surroundings of Cabo San Lucas. Two peaks were observed during spring and autumn in Mazatlán Bay during 1995-1996. The highest densities (20-360 cells.-l-1) were observed in coastal areas, whereas the lowest densities (1-14 cells.-l-1) were recorded in the open sea. During red tide events in 1985, 1989 and 1997, 144,000-256,000 cells.-l-1, 100,000-400,000 cells.-l-1, and 189,000-592,000 cells.ul-l was observed, respectively. During the red tide events C. dens varied, although sometimes was replaced by Skeletonema costatum or Pseudonitzchia spp and Ceratium furca. C. dens, seems to prefer areas with high productivity.

  3. "Where's the Bear? Over There!"--Creative Thinking and Imagination in Den Making

    ERIC Educational Resources Information Center

    Canning, Natalie

    2013-01-01

    This small scale research project examines opportunities for creative thinking and imagination through den making in a rural private day nursery with its own woodland area on the borders of England and Wales in the UK. The research is underpinned by sociocultural theory and is an ethnographic study of non-participant observations of children aged…

  4. Effect of age on respiratory carcinogenesis with diethyl-nitrosamine (DEN) in hamsters

    SciTech Connect

    Stinson, S.F.; Saffiotti, U.

    1986-03-01

    Groups of male and female Syrian golden hamsters were given 12 weekly s.c. injections of 10 mg/kg DEN beginning at 1 day (85 animals) or 8 weeks (70 animals) of age, and were held for lifetime observation. In hamsters receiving DEN from birth, the first respiratory tumors were observed at 15 experimental weeks; all animals were dead by 66 weeks with a 99% respiratory tumor incidence. Of these hamster, 87% developed carcinomas or adenomas in the nasal cavities, 75% papillomas of the trachea, larynx or extrapulmonary bronchi and 7% adenomas or adenocarcinomas of the peripheral lung. Hamsters given DEN from 8 weeks of age first showed respiratory tumors after 25 weeks with a 96% incidence by 62 weeks when all had died. Of these hamsters, 24% developed carcinomas or adenomas in the nasal cavities, 91% papillomas of the trachea, larynx or bronchi, and 9% adenomas or adenocarcinomas of the peripheral lung. In comparison, the nasal tumors in the first group were more anaplastic and invaded the brain more frequently than in the second. These results indicate that the nasal mucosa of newborns is more sensitive to carcinogenesis with DEN than is that of adults, while there appears to be little age-related susceptibility of the epithelium of the airways or lung. A serial sacrifice experiment is currently under way to study the cells of origin of the various tumors using immuno-histochemical and electron microscopic techniques.

  5. Sida rhombifolia ssp. retusa seed extract inhibits DEN induced murine hepatic preneoplasia and carbon tetrachloride hepatotoxicity.

    PubMed

    Poojari, Radhika; Gupta, Sanjay; Maru, Girish; Khade, Bharat; Bhagwat, Sanjay

    2009-01-01

    Sida rhombifolia ssp. retusa is a well established drug in the Ayurvedic system of medicine used for antirheumatism and antiasthmatism. Inhibitory effects of S. rhombifolia ssp. retusa seed extract on DEN induced hepatocellular preneoplastic foci and carbon tetrachloride (CCl4) induced hepatotoxicity was investigated in rats. Rats received DEN, 1ppm/g b.w. in drinking water for 6 weeks or CCl(4), 0.7 ml/kg i.p. once a week for 4 weeks and seed extract 50 mg, 100 mg/kg b.w. orally prior, during and after exposure to DEN/CCl4 for 20 or 5 weeks, respectively. Treatment with seed extract significantly inhibited the increase in DEN/CCl(4) induced activities of pre-cancerous marker enzymes; gamma-glutamyl transpeptidase, glutathione-S-transferase, hepatotoxicity marker enzymes; glutamate pyruvate transaminase, glutamate oxaloacetate transaminase and alkaline phosphatase as well as lipid peroxidase. Depleted glutathione, protein and albumin levels were restored. Also, histopathological and transmission electron microscopic studies showed prevention of cellular degenerative changes. The chemopreventive and hepatoprotective potentials of seed extract are due to free radical scavenging activity and restoration of cellular structural integrity.

  6. Iron promotes DEN initiated GST-P foci in rat liver.

    PubMed

    Carthew, P; Nolan, B M; Smith, A G; Edwards, R E

    1997-03-01

    Diethylnitrosamine (DEN) was administered to rats as a single dose, which is known not to give rise to liver tumours without subsequent promotion. Iron dextran (Fe/Dex) was then administered parenterally to the animals, to induce iron overload. At 3 and 6 months after the final Fe/Dex treatments, livers were examined quantitatively for the numbers of the placental form of glutathione-S-transferase (GST-P) expressing foci, the area occupied by these foci and their size distribution. The results demonstrate that iron not only increased the number of foci after DEN initiation in the rat liver, but that the area occupied by these lesions increased significantly between 3 and 6 months after initiation. There is no evidence that iron increased the number of GST-P expressing foci present in rats not exposed to DEN. This indicates that iron did not act as an initiator in this rodent model of liver cancer. The increase in the area of the liver occupied by the foci in iron and DEN treated rats was due to an increase in the size of the foci, as well as to an increase in the number of foci. This is the first demonstration that iron can act as a promoter of DEN initiated hepatocytes. It also demonstrates that fibrogenesis is not an absolute requirement for the promotion, by iron, of liver foci in the rat, and that this could also be the case for iron overload in man. Iron may also act as a promoter of already initiated hepatocytes in the development of human liver cancer, as it does in the rat.

  7. Importance of Native Grassland Habitat for Den-Site Selection of Indian Foxes in a Fragmented Landscape

    PubMed Central

    Punjabi, Girish Arjun; Chellam, Ravi; Vanak, Abi Tamim

    2013-01-01

    Fragmentation of native habitats is now a ubiquitous phenomenon affecting wildlife at various scales. We examined selection of den-sites (n = 26) by Indian foxes (Vulpes bengalensis) in a highly modified short-grassland landscape in central India (Jan-May, 2010). At the scale of the home-range, defined by an 800 m circular buffer around den sites, we examined the effect of land-cover edges and roads on selection of sites for denning using a distance-based approach. At the smaller den-area scale, defined by a 25 m x 25 m plot around den and paired available sites, the effect of microhabitat characteristics was examined using discrete-choice models. Indian foxes selected den-sites closer to native grasslands (t = -9.57, P < 0.001) and roads (t = -2.04, P = 0.05) than random at the home-range scale. At the smaller scale, abundance of rodents and higher visibility increased the odds of selection of a site by eight and four times respectively, indicating resource availability and predator avoidance to be important considerations for foxes. Indian foxes largely chose to den in human-made structures, indicated by the proportion of dens found in earthen bunds (0.69) and boulder piles (0.27) in the study area. With agricultural expansion and human modification threatening native short-grassland habitats, their conservation and effective management in human-dominated landscapes will benefit the Indian fox. The presence of some human-made structures within native grasslands would also be beneficial for this den-dependent species. We suggest future studies examine the impact of fragmentation and connectivity of grasslands on survival and reproductive success of the Indian fox. PMID:24098494

  8. Importance of native grassland habitat for den-site selection of Indian foxes in a fragmented landscape.

    PubMed

    Punjabi, Girish Arjun; Chellam, Ravi; Vanak, Abi Tamim

    2013-01-01

    Fragmentation of native habitats is now a ubiquitous phenomenon affecting wildlife at various scales. We examined selection of den-sites (n = 26) by Indian foxes (Vulpes bengalensis) in a highly modified short-grassland landscape in central India (Jan-May, 2010). At the scale of the home-range, defined by an 800 m circular buffer around den sites, we examined the effect of land-cover edges and roads on selection of sites for denning using a distance-based approach. At the smaller den-area scale, defined by a 25 m x 25 m plot around den and paired available sites, the effect of microhabitat characteristics was examined using discrete-choice models. Indian foxes selected den-sites closer to native grasslands (t = -9.57, P < 0.001) and roads (t = -2.04, P = 0.05) than random at the home-range scale. At the smaller scale, abundance of rodents and higher visibility increased the odds of selection of a site by eight and four times respectively, indicating resource availability and predator avoidance to be important considerations for foxes. Indian foxes largely chose to den in human-made structures, indicated by the proportion of dens found in earthen bunds (0.69) and boulder piles (0.27) in the study area. With agricultural expansion and human modification threatening native short-grassland habitats, their conservation and effective management in human-dominated landscapes will benefit the Indian fox. The presence of some human-made structures within native grasslands would also be beneficial for this den-dependent species. We suggest future studies examine the impact of fragmentation and connectivity of grasslands on survival and reproductive success of the Indian fox.

  9. HyDEn: a hybrid steganocryptographic approach for data encryption using randomized error-correcting DNA codes.

    PubMed

    Tulpan, Dan; Regoui, Chaouki; Durand, Guillaume; Belliveau, Luc; Léger, Serge

    2013-01-01

    This paper presents a novel hybrid DNA encryption (HyDEn) approach that uses randomized assignments of unique error-correcting DNA Hamming code words for single characters in the extended ASCII set. HyDEn relies on custom-built quaternary codes and a private key used in the randomized assignment of code words and the cyclic permutations applied on the encoded message. Along with its ability to detect and correct errors, HyDEn equals or outperforms existing cryptographic methods and represents a promising in silico DNA steganographic approach.

  10. HyDEn: A Hybrid Steganocryptographic Approach for Data Encryption Using Randomized Error-Correcting DNA Codes

    PubMed Central

    Regoui, Chaouki; Durand, Guillaume; Belliveau, Luc; Léger, Serge

    2013-01-01

    This paper presents a novel hybrid DNA encryption (HyDEn) approach that uses randomized assignments of unique error-correcting DNA Hamming code words for single characters in the extended ASCII set. HyDEn relies on custom-built quaternary codes and a private key used in the randomized assignment of code words and the cyclic permutations applied on the encoded message. Along with its ability to detect and correct errors, HyDEn equals or outperforms existing cryptographic methods and represents a promising in silico DNA steganographic approach. PMID:23984392

  11. CheckDen, a program to compute quantum molecular properties on spatial grids.

    PubMed

    Pacios, Luis F; Fernandez, Alberto

    2009-09-01

    CheckDen, a program to compute quantum molecular properties on a variety of spatial grids is presented. The program reads as unique input wavefunction files written by standard quantum packages and calculates the electron density rho(r), promolecule and density difference function, gradient of rho(r), Laplacian of rho(r), information entropy, electrostatic potential, kinetic energy densities G(r) and K(r), electron localization function (ELF), and localized orbital locator (LOL) function. These properties can be calculated on a wide range of one-, two-, and three-dimensional grids that can be processed by widely used graphics programs to render high-resolution images. CheckDen offers also other options as extracting separate atom contributions to the property computed, converting grid output data into CUBE and OpenDX volumetric data formats, and perform arithmetic combinations with grid files in all the recognized formats.

  12. Technische Systeme für den Herzersatz und die Herzunterstützung

    NASA Astrophysics Data System (ADS)

    Schöb, Reto; Loree, Howard M.

    Herzkrankheiten verursachen allein in den Vereinigten Staaten jährlich mehr als 700’000 Todesfälle. Ungefähr 3 Millionen Patienten in den U.S.A. leiden gemäss der American Heart Association (AHA) und dem National Heart, Lung and Blood Institute (NHLBI) an kongestivem Herzversagen (Congestive Heart Failure, CHF), welches eine chronische, sehr entkräftende und degenerative Krankheit ist: Das Herz ist dabei unfähig, hinreichend Blut zu den Organen des Körpers zu pumpen. Über 400’000 Fälle von CHF werden jedes Jahr diagnostiziert. Ähnliche Zahlen werden für Europa und Japan zusammen geschätzt. Basierend auf Daten vom AHA und NHLBI beträgt die fünfjährige Überlebensrate für CHF-Patienten lediglich etwa 50% [1]. 70’000-120’000 dieser Patienten könnten von einer Herzverpflanzung profitieren. 1999 wurden in den USA aber nur 2185 Herztransplantationen durchgeführt während die Warteliste über 4000 Patienten beträgt [2]. Ein akuter Mangel an Spenderherzen und die enormen Kosten (250’000-400’000 USD pro Patient) sind die begrenzenden Faktoren für Herztransplantationen [3]. Dies bedeutet, dass eine riesige Anzahl von Patienten durch ein zuverlässiges und verschleissfreies, nichtthrombotisches, total implantierbares, künstliches Herz gerettet werden könnten. Bis heute jedoch kein derartiges Implantat kommerziell verfügbar.

  13. Case study of total energy system, Sher-Den Mall, Sherman, Texas

    SciTech Connect

    Myrtetus, G.B.; Levey, M.D.

    1980-12-01

    The Sher-Den Mall shopping center receives all of its electricity and heating and cooling energy from a total energy plant located within the shopping center proper. Four engine-generator units are fueled primarily by natural gas, with some fuel oil use. The following are presented: initial corporate planning, investigation, and feasibility studies; a description of the total energy system; capital costs; plant operations, and revenue structure. Tables, figures, exhibits, and equipment specification lists are presented. (MHR)

  14. Computational anatomy of the dens axis evaluated by quantitative computed tomography: Implications for anterior screw fixation.

    PubMed

    Gehweiler, Dominic; Wähnert, Dirk; Meier, Norbert; Spruit, Maarten; Raschke, Michael Johannes; Richards, Robert Geoff; Noser, Hansrudi; Kamer, Lukas

    2017-01-05

    The surgical fracture fixation of the odontoid process (dens) of the second cervical vertebra (C2/axis) is a challenging procedure, particularly in elderly patients affected by bone loss, and includes screw positioning close to vital structures. The aim of this study was to provide an extended anatomical knowledge of C2, the bone mass distribution and bone loss, and to understand the implications for anterior screw fixation. One hundred and twenty standard clinical quantitative computed tomography (QCT) scans of the intact cervical spine from 60 female and 60 male European patients, aged 18-90 years, were used to compute a three-dimensional statistical model and an averaged bone mass model of C2. Shape and size variability was assessed via principal component analysis (PCA), bone mass distribution by thresholding and via virtual core drilling, and the screw placement via virtual positioning of screw templates. Principal component analysis (PCA) revealed a highly variable anatomy of the dens with size as the predominant variation according to the first principal component (PC) whereas shape changes were primarily described by the remaining PCs. The bone mass distribution demonstrated a characteristic 3D pattern, and remained unchanged in the presence of bone loss. Virtual screw positioning of two 3.5 mm dens screws with a 1 mm safety zone was possible in 81.7% in a standard, parallel position and in additional 15.8% in a twisted position. The approach permitted a more detailed anatomical assessment of the dens axis. Combined with a preoperative QCT it may further improve the diagnostic procedure of odontoid fractures. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

  15. Catalogue of polar bear (Ursus maritimus) maternal den locations in the Beaufort Sea and neighboring regions, Alaska, 1910-2010

    USGS Publications Warehouse

    Durner, George M.; Fischbach, Anthony S.; Amstrup, Steven C.; Douglas, David C.

    2010-01-01

    This report presents data on the approximate locations and methods of discovery of 392 polar bear (Ursus maritimus) maternal dens found in the Beaufort Sea and neighboring regions between 1910 and 2010 that are archived by the U.S. Geological Survey, Alaska Science Center, Anchorage, Alaska. A description of data collection methods, biases associated with collection method, primary time periods, and spatial resolution are provided. Polar bears in the Beaufort Sea and nearby regions den on both the sea ice and on land. Standardized VHF surveys and satellite radio telemetry data provide a general understanding of where polar bears have denned in this region over the past 3 decades. Den observations made during other research activities and anecdotal reports from other government agencies, coastal residents, and industry personnel also are reported. Data on past polar bear maternal den locations are provided to inform the public and to provide information for natural resource agencies in planning activities to avoid or minimize interference with polar bear maternity dens.

  16. Assessment of adverse effects of neurotropic drugs in monkeys with the "drug effects on the nervous system" (DENS) scale.

    PubMed

    Uthayathas, Subramaniam; Shaffer, Christopher L; Menniti, Frank S; Schmidt, Christopher J; Papa, Stella M

    2013-04-30

    Research into therapeutics for neuropsychiatric disorders is increasingly focusing on drugs with new mechanisms of action, and such agents are often assessed in preclinical studies using nonhuman primates. However, researchers lack a standardised method to compare different drugs for common adverse effects on the nervous system. We have developed a new scale for this purpose, named "Drug Effects on the Nervous System" (DENS), and tested its utility in an analysis of the second-generation antipsychotic risperidone in monkeys. The behavioural effects of risperidone over a ten-fold clinically relevant exposure range were rated with the DENS scale and compared with a standard motor disability scale for primates. The ratings were correlated with projected D2 and 5-HT2A receptor occupancies over time. The DENS scale detected dose-dependent side effects of risperidone in addition to the motor effects detected with the motor disability scale, including cognitive, sensorimotor and autonomic functions. A consistent temporal association between the DENS scale changes and the projected D2 receptor occupancy was observed, and the DENS scale ratings demonstrated high inter-rater reliability. These results demonstrate the usefulness of the DENS scale as a highly sensitive, reliable and accurate method to identify common adverse effects of risperidone and potentially other neurotropics for translational studies in primates.

  17. Reconnaissance study of late quaternary faulting along cerro GoDen fault zone, western Puerto Rico

    USGS Publications Warehouse

    Mann, P.; Prentice, C.S.; Hippolyte, J.-C.; Grindlay, N.R.; Abrams, L.J.; Lao-Davila, D.

    2005-01-01

    The Cerro GoDen fault zone is associated with a curvilinear, continuous, and prominent topographic lineament in western Puerto Rico. The fault varies in strike from northwest to west. In its westernmost section, the fault is ???500 m south of an abrupt, curvilinear mountain front separating the 270- to 361-m-high La CaDena De San Francisco range from the Rio A??asco alluvial valley. The Quaternary fault of the A??asco Valley is in alignment with the bedrock fault mapped by D. McIntyre (1971) in the Central La Plata quadrangle sheet east of A??asco Valley. Previous workers have postulated that the Cerro GoDen fault zone continues southeast from the A??asco Valley and merges with the Great Southern Puerto Rico fault zone of south-central Puerto Rico. West of the A??asco Valley, the fault continues offshore into the Mona Passage (Caribbean Sea) where it is characterized by offsets of seafloor sediments estimated to be of late Quaternary age. Using both 1:18,500 scale air photographs taken in 1936 and 1:40,000 scale photographs taken by the U.S. Department of Agriculture in 1986, we iDentified geomorphic features suggestive of Quaternary fault movement in the A??asco Valley, including aligned and Deflected drainages, apparently offset terrace risers, and mountain-facing scarps. Many of these features suggest right-lateral displacement. Mapping of Paleogene bedrock units in the uplifted La CaDena range adjacent to the Cerro GoDen fault zone reveals the main tectonic events that have culminated in late Quaternary normal-oblique displacement across the Cerro GoDen fault. Cretaceous to Eocene rocks of the La CaDena range exhibit large folds with wavelengths of several kms. The orientation of folds and analysis of fault striations within the folds indicate that the folds formed by northeast-southwest shorTening in present-day geographic coordinates. The age of Deformation is well constrained as late Eocene-early Oligocene by an angular unconformity separating folDed, Deep

  18. Photoprotective implications of leaf variegation in E. dens-canis L. and P. officinalis L.

    PubMed

    Esteban, Raquel; Fernández-Marín, Beatriz; Becerril, José María; García-Plazaola, José Ignacio

    2008-08-25

    Variegated leaves occur rarely in nature, but there are some species, primarily in the forest understory, that possess this characteristic. We recently studied two variegated plants: Erytronium dens-canis L., which is characterised by a pattern of red patches and Pulmonaria officinalis L., with light green spots. These non-green areas could attenuate light reaching mesophyll cells with respect to green sections. The aim of the study was to verify whether such red and light green parts are more photoprotected than green ones and if this trait could be of adaptive value. Red patches in E. dens-canis were due to a single layer of red cells in the upper parenchyma, which accumulated anthocyanins. Light green spots in P. officinalis were caused by the presence of loosely arranged cells instead of a well-established layer of packed cells in the palisade parenchyma. Chlorophyll fluorescence imaging was performed under light treatment, showing a greater decrease of photochemical efficiency in red and light green patches than in green sections. Differences in the extent of photochemical efficiency among patches were not attributable to different activation of the xanthophyll cycle. These observations failed to confirm our initial hypothesis, but they questioned the physiological reason for this higher sensitivity in red and light green patches of photosynthetic tissues. Chlorophyll fluorescence imaging was therefore performed in the field. The same pattern of photochemical efficiency was maintained only in E. dens-canis. The current results demonstrate that in both species the benefits of variegation, if any, are different from enhanced photosynthetic performance.

  19. Hubble constant from Pritchet and von den Bergh's nova distance to the Virgo cluster

    SciTech Connect

    Sandage, A.; Tammann, G.A.

    1988-05-01

    Two reasons are offered why the value for H(0) of 69 + or - 14 km/s/Mpc of Pritchet and van den Bergh (1987) is likely to be too high by about 20 percent even when their value of 6.8 + or - 0.4 for the M31-Virgo modulus difference is adopted. One reason concerns the free expansion velocity of the Virgo cluster core and the other concerns the apparent distance modulus of M31. Reasons for adopting a global H(0) value of 56 + or - 12 km/s/Mpc are discussed. 25 references.

  20. Successful orthograde treatment of dens invaginatus Type 3 with a main C-shaped canal based on cone-beam computed tomography evaluation

    PubMed Central

    Solomonov, Michael; Itzhak, Joe Ben; Levin, Avi; Katzenell, Vered; Shemesh, Avi

    2016-01-01

    Dens invaginatus is a rare anatomic variation that is found primarily in maxillary lateral incisors. The management of dens invaginatus is challenging for clinicians; diagnosing the type of malformation, choosing the most appropriate treatment, and carrying out treatment are complicated by the intricate root system of these teeth. The following case report describes the diagnosis and treatment planning of dens invaginatus Type 3 after cone-beam computed tomography evaluation. PMID:27994325

  1. Insights from the Den: How Hibernating Bears May Help Us Understand and Treat Human Disease.

    PubMed

    Berg von Linde, Maria; Arevström, Lilith; Fröbert, Ole

    2015-10-01

    Hibernating brown bears (Ursus arctos) and black bears (Ursus americanus) spend half of the year in a physically inactive state inside their winter dens without food intake and defecating and no or little urination. Under similar extreme conditions, humans would suffer from loss of lean body mass, heart failure, thrombosis, azotemia, osteoporosis, and more. However, bears exit the den in the spring strong without organ injuries. Translational animal models are used in human medicine but traditional experimental animals have several shortcomings; thus, we believe that it is time to systematically explore new models. In this review paper, we describe physiological adaptations of hibernating bears and how similar adaptations in humans could theoretically alleviate medical conditions. The bear has solved most of the health challenges faced by humans, including heart and kidney disease, atherosclerosis and thrombosis, and muscle wasting and osteoporosis. Understanding and applying this library of information could lead to a number of major discoveries that could have implications for the understanding and treatment of human disease.

  2. Dens Axis Vertebroplasty Combined with C 3 Vertebral Body Arthroplasty. Case Study.

    PubMed

    Guzik, Grzegorz

    2015-01-01

    Spinal tumors are most commonly located in the thoracic and lumbar spine, less commonly in the cervical section of the spine. Diagnosis is usually late and surgery is not radical. Myeloma is one of the most frequent metastatic spinal tumors. Surgical treatment of osteolytic lesions in the spine involves posterior and anterior stabilization, full or partial tumorectomies as well as decompression of neural structures. Bone cement injection has been increasingly used in plastic surgery of vertebral bodies and is most frequently performed percutaneously in the thoracic and lumbar spine. Cervical vertebroplasty can be performed both percutaneously and after anterior exposure of the spine. The dens axis can also be approached transorally. The safest surgical technique seems to be the Southwick approach, which allows exposure of the spine at C2-Th2 and, if necessary, can be extended both proximally and distally. Cemented cervical vertebroplasty, especially dens axis vertebroplasty, shows good results, yet this technique has rarely been described in the literature. It has the advantage of early patient mobility and little limitation of motion of the spine. Cervical vertebroplasty can be successfully combined with other procedures utilizing the same surgical approach in a single-stage operation. Post-resection anterior stabilization of the cervical spine with plates and vertebral body prosthesis allows for good stability of the spine and makes it possible to restore the spinal axis and curvatures.

  3. Nonsurgical management of a dilacerated maxillary lateral incisor with type III dens invaginatus: a case report.

    PubMed

    Gound, Tom G; Maixner, David

    2004-06-01

    Type III dens invaginatus is a developmental anomaly characterized by an enamel-lined channel that originates on the coronal surface and passes apically through part or all of the root and exits into the periodontal ligament. In this case report, a 13-yr-old male had a Type III dens that exited at the midroot level of tooth #7. At that same level, the root dilacerated severely to the mesial, and a periradicular radiolucency was present on the distal. A 12-mm periodontal defect was present on tooth #6 and a sinus tract was present. All maxillary anterior teeth responded normally to pulp vitality testing, and no other abnormal probing depths were present. The channel opening in the crown was located, and the channel was negotiated, enlarged, and filled with calcium hydroxide. Thirteen weeks later, the probing was normal and the canal was obturated with gutta-percha and restored. Two- and 6-yr recalls showed complete healing of the bony defects and continued normal responses to vitality testing.

  4. Erythronium dens-canis L. (Liliaceae): an unusual case of change of leaf mottling.

    PubMed

    La Rocca, Nicoletta; Pupillo, Paolo; Puppi, Giovanna; Rascio, Nicoletta

    2014-01-01

    Erythronium dens-canis is an early-flowering understory lily of southern Europe with two leaves and a single flower, although a number of plants have only one leaf and do not flower. The leaves are mottled with silvery flecks and brown patches, that gradually vanish turning to a lively green color. The nature and function of this striking variegation pattern were investigated in differently colored leaf parts following the springtime color change. Tissue organization was examined by light and electron microscopy; photosynthetic pigments were analyzed by spectrophotometry and HPLC; chlorophyll fluorescence parameters were evaluated by MINI-PAM. The results showed that brown patches originated in vacuolar anthocyanins in the subepidermal cell layer while air spaces between the upper epidermis and underlying chlorenchyma resulted in silvery flecks. The two leaf areas did not differ in photosynthetic pigments, chloroplast organization and photosynthetic parameters (F(v)/F(m), NPQ, rETR). Greening of brown patches due to anthocyanin resorption was faster in non-flowering plants than in flowering ones, occurring only when young fruits were developing. Anthocyanin disappearance did not change the structural-functional features of photosynthetic tissues. As a whole the results suggest that the anthocyanin pigmentation of E. dens-canis leaves does not affect the photosynthetic light use and has no photoprotective function. It is proposed that the complex leaf color pattern may act as a camouflage to escape herbivores, while the reflective silvery spots may have a role in attracting pollinators of this early-flowering species.

  5. Management of Oehler's Type III Dens Invaginatus Using Cone Beam Computed Tomography

    PubMed Central

    Ranganathan, Jaya; Rangarajan Sundaresan, Mohan Kumar; Ramasamy, Srinivasan

    2016-01-01

    Dens Invaginatus is a dental malformation that poses diagnostic difficulties in the clinical context. This anomaly may increase the risk of pulp disease and can potentially complicate endodontic procedure due to the aberrant root canal anatomy. Compared to conventional radiographs, three-dimensional images obtained with Cone Beam Computed Tomography (CBCT) are invaluable in the diagnosis of the extent of this anomaly and in the appropriate treatment planning. Oehler's classification (1957) for Dens Invaginatus (DI) into three types depending on the depth of the invagination has been used for treatment planning. Of the three types Type III DI is characterized by infolding of the enamel into the tooth up to the root apex and is considered as the most severe variant of DI and hence the most challenging to treat endodontically, due to the morphological complexities. This report describes a case of Oehler's Type III DI in a necrotic permanent maxillary lateral incisor in which CBCT images played a key role in diagnosis and treatment planning. The case was managed successfully by a combination of nonsurgical and surgical endodontic therapy with orthograde and retrograde thermoplastic gutta percha obturation. PMID:27069697

  6. Characteristics of dens used by radiocollared San Joaquin kit fox, Vulpes macrotis mutica, Naval Petroleum Reserve No. 1, Kern County, California

    SciTech Connect

    Berry, W.H.; O'Farrell, T.P.; Kato, T.T.; McCue, P.M.

    1987-08-01

    A total of 946 dens used by radiocollared San Joaquin kit foxes, Vulpes macrotis mutica, were observed on Naval Petroleum Reserve No. 1 and surrounding lands in Kern County, California. Of these, 887 were typical subterranean dens located in 65 sections, and 59 were atypical dens in man-made structures located in 24 sections and in two pipe storage yards. Although the number of entrances to dens ranged between 1 and 17, most (90%) had six or fewer entrances and the average, which did not differ between developed and undeveloped habitats, was 3.4. Entrances were significantly higher than wide, and 53% had ramp-shaped dirt berms. Dens had an average slope angle of 16.1/sup 0/ and more were found on slopes than in flats. Fewer dens faced the northwest quadrant and more faced the southern quadrant than expected. Evidence of kit foxes (tracks, scats, or prey remains) was observed at 80% of the dens, but 11% were not associated with kit fox sign (matted vegetation or trails) even though they were occupied. Human disturbances, most frequently roads, were observed in the immediate vicinity of 78% of the dens. Most (93%) atypical dens were in metal pipes, three were in buried wooden culverts, and one was under a concrete slab. 27 refs., 7 figs., 10 tabs.

  7. Protective effect of Punica granatum peel and Vitis vinifera seeds on DEN-induced oxidative stress and hepatocellular damage in rats.

    PubMed

    Kumar, Ashok K; Vijayalakshmi, K

    2015-01-01

    This study was designed to find out the efficacy of ethanol extracts of Punica granatum peel and Vitis vinifera seeds on diethylnitrosamine (DEN)-induced oxidative stress and hepatocellular damage in Wistar rats. Rats were divided into four groups. The first group served as normal control, and the second group received DEN at a dose of 200 mg/kg body weight by single intraperitoneal administration. The third one received DEN as in DEN-treated group and co-treated with 400 mg/kg P. granatum peel extract. The final group also received DEN and co-treated with 400 mg/kg V. vinifera seed extract. DEN administration to rats resulted in significantly elevated levels of serum SGPT, SGOT, ALP, and GGT which is indicative of hepatocellular damage. DEN-induced oxidative stress was confirmed by elevated levels of lipid peroxides and decreased activities of superoxide dismutase, catalase, and glutathione peroxidase in the serum and liver tissues. The status of non-enzymatic antioxidants like vitamin C, vitamin E, and reduced glutathione were also found to be decreased in serum and tissues of DEN-administered rats. Co-treatment with the P. granatum peel and V. vinifera seed extracts orally for 12 weeks significantly reversed the DEN-induced alterations in the serum and liver tissues.

  8. Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication.

    PubMed

    Suzuki, Youichi; Chin, Wei-Xin; Han, Qi'En; Ichiyama, Koji; Lee, Ching Hua; Eyo, Zhi Wen; Ebina, Hirotaka; Takahashi, Hirotaka; Takahashi, Chikako; Tan, Beng Hui; Hishiki, Takayuki; Ohba, Kenji; Matsuyama, Toshifumi; Koyanagi, Yoshio; Tan, Yee-Joo; Sawasaki, Tatsuya; Chu, Justin Jang Hann; Vasudevan, Subhash G; Sano, Kouichi; Yamamoto, Naoki

    2016-01-01

    Dengue virus (DENV) is one of the most important arthropod-borne pathogens that cause life-threatening diseases in humans. However, no vaccine or specific antiviral is available for dengue. As seen in other RNA viruses, the innate immune system plays a key role in controlling DENV infection and disease outcome. Although the interferon (IFN) response, which is central to host protective immunity, has been reported to limit DENV replication, the molecular details of how DENV infection is modulated by IFN treatment are elusive. In this study, by employing a gain-of-function screen using a type I IFN-treated cell-derived cDNA library, we identified a previously uncharacterized gene, C19orf66, as an IFN-stimulated gene (ISG) that inhibits DENV replication, which we named Repressor of yield of DENV (RyDEN). Overexpression and gene knockdown experiments revealed that expression of RyDEN confers resistance to all serotypes of DENV in human cells. RyDEN expression also limited the replication of hepatitis C virus, Kunjin virus, Chikungunya virus, herpes simplex virus type 1, and human adenovirus. Importantly, RyDEN was considered to be a crucial effector molecule in the IFN-mediated anti-DENV response. When affinity purification-mass spectrometry analysis was performed, RyDEN was revealed to form a complex with cellular mRNA-binding proteins, poly(A)-binding protein cytoplasmic 1 (PABPC1), and La motif-related protein 1 (LARP1). Interestingly, PABPC1 and LARP1 were found to be positive modulators of DENV replication. Since RyDEN influenced intracellular events on DENV replication and, suppression of protein synthesis from DENV-based reporter construct RNA was also observed in RyDEN-expressing cells, our data suggest that RyDEN is likely to interfere with the translation of DENV via interaction with viral RNA and cellular mRNA-binding proteins, resulting in the inhibition of virus replication in infected cells.

  9. Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication

    PubMed Central

    Ichiyama, Koji; Lee, Ching Hua; Eyo, Zhi Wen; Ebina, Hirotaka; Takahashi, Hirotaka; Takahashi, Chikako; Tan, Beng Hui; Hishiki, Takayuki; Ohba, Kenji; Matsuyama, Toshifumi; Koyanagi, Yoshio; Tan, Yee-Joo; Sawasaki, Tatsuya; Chu, Justin Jang Hann; Vasudevan, Subhash G.; Sano, Kouichi; Yamamoto, Naoki

    2016-01-01

    Dengue virus (DENV) is one of the most important arthropod-borne pathogens that cause life-threatening diseases in humans. However, no vaccine or specific antiviral is available for dengue. As seen in other RNA viruses, the innate immune system plays a key role in controlling DENV infection and disease outcome. Although the interferon (IFN) response, which is central to host protective immunity, has been reported to limit DENV replication, the molecular details of how DENV infection is modulated by IFN treatment are elusive. In this study, by employing a gain-of-function screen using a type I IFN-treated cell-derived cDNA library, we identified a previously uncharacterized gene, C19orf66, as an IFN-stimulated gene (ISG) that inhibits DENV replication, which we named Repressor of yield of DENV (RyDEN). Overexpression and gene knockdown experiments revealed that expression of RyDEN confers resistance to all serotypes of DENV in human cells. RyDEN expression also limited the replication of hepatitis C virus, Kunjin virus, Chikungunya virus, herpes simplex virus type 1, and human adenovirus. Importantly, RyDEN was considered to be a crucial effector molecule in the IFN-mediated anti-DENV response. When affinity purification-mass spectrometry analysis was performed, RyDEN was revealed to form a complex with cellular mRNA-binding proteins, poly(A)-binding protein cytoplasmic 1 (PABPC1), and La motif-related protein 1 (LARP1). Interestingly, PABPC1 and LARP1 were found to be positive modulators of DENV replication. Since RyDEN influenced intracellular events on DENV replication and, suppression of protein synthesis from DENV-based reporter construct RNA was also observed in RyDEN-expressing cells, our data suggest that RyDEN is likely to interfere with the translation of DENV via interaction with viral RNA and cellular mRNA-binding proteins, resulting in the inhibition of virus replication in infected cells. PMID:26735137

  10. Remote identification of potential polar bear maternal denning habitat in northern Alaska using airborne LiDAR

    NASA Astrophysics Data System (ADS)

    Jones, B. M.; Durner, G. M.; Stoker, J.; Shideler, R.; Perham, C.; Liston, G. E.

    2013-12-01

    Polar bear (Ursus maritimus) populations throughout the Arctic are being threatened by reductions in critical sea ice habitat. Throughout much of their range, polar bears give birth to their young in winter dens that are excavated in snowdrifts. New-born cubs, which are unable to survive exposure to Arctic winter weather, require 2-3 months of the relatively warm, stable, and undisturbed environment of the den for their growth. In the southern Beaufort Sea (BS), polar bears may den on the Alaskan Arctic Coastal Plain (ACP).The proportion of dens occurring on land has increased because of reductions in stable multi-year ice, increases in unconsolidated ice, and lengthening of the fall open-water period. Large portions of the ACP are currently being used for oil and gas activities and proposed projects will likely expand this footprint in the near future. Since petroleum exploration and development activities increase during winter there is the potential for human activities to disturb polar bears in maternal dens. Thus, maps showing the potential distribution of terrestrial denning habitat can help to mitigate negative interactions. Prior remote sensing efforts have consisted of manual interpretation of vertical aerial photography and automated classification of Interferometric Synthetic Aperture (IfSAR) derived digital terrain models (DTM) (5-m spatial resolution) focused on the identification of snowdrift forming landscape features. In this study, we assess the feasibility of airborne Light Detection and Ranging (LiDAR) data (2-m spatial resolution) for the automated classification of potential polar bear maternal denning habitat in a 1,400 km2 area on the central portion of the ACP. The study region spans the BS coast from the Prudhoe Bay oilfield in the west to near Point Thompson in the east and extends inland from 10 to 30 km. Approximately 800 km2 of the study area contains 19 known den locations, 51 field survey sites with information on bank height and

  11. The Political Views of Students at the Universities of the Armed Forces in Comparison to Those of Students at Public Institutions (Die politischen Orientierungen der Studenten an den Universitaeten der Bundeswehr im Vergleich zu den Studenten an oeffentlichen Hochschulen)

    DTIC Science & Technology

    2001-12-01

    zu sein scheint" ( Noelle - Neumann , E. und Petersen, Th., S. 40).5 4 Gerade auch bei den rasant zunehmenden Aufgaben der Bundeswehr bei...Bonnemann A., Hoffmann-Broll U., 1999 Studentische Orientierungen zwischen akademischer und soldatischer Lebenswelt. Noelle - Neumann E., Petersen Th

  12. Diagnosis and Treatment of a Type III Dens Invagination Using Cone-Beam Computed Tomography

    PubMed Central

    Bahmani, Mohsen; Adl, Alireza; Javanmardi, Samane; Naghizadeh, Sina

    2016-01-01

    A 20-year-old man presented with the history of pain and swelling in the anterior maxillary segment. The periapical radiography was indicative of a dental anomaly in right maxillary lateral incisor. Due to the insufficient information from conventional radiography, cone-beam computed tomography (CBCT) was ordered. CBCT showed apical root resorption, large apical lucency and two separate canals with distinct apical foramen (Oehlers type III dens invagination). The CBCT image was used as a guide for dentine removal with an ultrasonic tip. Conventional root canal therapy was done using lateral compaction technique. One-and two-year follow-up radiographies revealed periapical repair and absence of symptoms. PMID:27790268

  13. Altered denA and anr gene expression in aminoglycoside adaptive resistance in Pseudomonas aeruginosa.

    PubMed

    Karlowsky, J A; Hoban, D J; Zelenitsky, S A; Zhanel, G G

    1997-09-01

    Adaptive resistance to aminoglycoside killing and cytoplasmic accumulation occurs in cultures of originally susceptible Pseudomonas aeruginosa following an initial incubation with aminoglycoside. Anaerobiosis has also been reported to reduce bacterial killing and limit cytoplasmic aminoglycoside accumulation. We hypothesized that a common mechanism may facilitate reduced bacterial killing and aminoglycoside accumulation in both cases. Northern blot analysis of P. aeruginosa adaptively resistant to gentamicin demonstrated increased mRNA levels of both denA (nitrite reductase), which facilitates terminal electron acceptance in the anaerobic respiratory pathway, and its regulatory protein, ANR, in the absence of promoter DNA sequence changes, when compared with controls. These observations suggested that P. aeruginosa may regulate the expression of genes in its anaerobic respiratory pathway in response to aminoglycosides and may explain, at least partially, P. aeruginosa adaptive resistance to aminoglycosides.

  14. [An alternative dorsal fusion technique after transoral dens resection in basilar impression with atlas assimilation].

    PubMed

    Kaden, B; Schramm, J; Koch, W; Solymosi, L

    1998-01-01

    Current therapy of basilar impression includes transoral dens resection. The essential disadvantage of this procedure is the instability of C1/C2 due to loss of the transverse ligament. We describe two patients in whom this instability was treated by modified screwing. Using MAGERL-screws between C0-C2 an interposition of an iliac graft between the occiput and the arc of C2 was made. Neurological symptoms improved in both patients postoperatively. In both cases stable fusion C0/C2 was achieved with an additional treatment with a HALO-fixateur for eight weeks. In our opinion the combined transoral/dorsal procedure is most suitable and efficient in treatment of basilar impressions. By this approach both, decompression of the myelon as well as stable fusion C0/C2, is achieved.

  15. Acute non-ambulatory tetraparesis with absence of the dens in two large breed dogs: case reports with a radiographic study of relatives

    PubMed Central

    2013-01-01

    Background Non-ambulatory tetraparesis with an absence of the dens of C2 (axis) has not previously been reported in large breed dogs. An absence or hypoplasia of the dens has been reported in both small, medium and large breed dogs, but not in closely related animals. Methods Two young large-breed dogs (a German shepherd and a Standard poodle) both with an acute onset of non-ambulatory tetraparesis were subjected to physical, neurological and radiographic examinations. Both dogs were euthanased and submitted for postmortem examination within one week of onset of clinical signs. To investigate possible heritability of dens abnormalities, oblique radiographs of the cranial cervical vertebrae were taken of nine and eighteen dogs related to the German shepherd and the Standard poodle, respectively. Results Absence of the dens, atlantoaxial instability and extensive spinal cord injury was found in both case dogs. Radiographs revealed a normal dens in both parents and in the seven littermates of the German shepherd. An absence or hypoplasia of the dens was diagnosed in six relatives of the Standard poodle. Conclusions Atlantoaxial subluxation with cervical spinal cord injury should be considered as a differential diagnosis in non-ambulatory tetraparetic young large breed dogs. Absence of the dens and no history of external trauma increase the likelihood for this diagnosis. This study provides evidence to suggest that absence or hypoplasia of the dens is inherited in an autosomal way in Standard poodle dogs. PMID:23591104

  16. Differential Diagnosis of Japanese Encephalitis Virus Infections with the Inbios JE Detect™ and DEN Detect™ MAC-ELISA Kits

    PubMed Central

    Johnson, Barbara W.; Goodman, Christin H.; Jee, Youngmee; Featherstone, David A.

    2016-01-01

    Japanese encephalitis virus (JEV) is the leading cause of pediatric viral neurological disease in Asia. The JEV-specific IgM antibody-capture enzyme-linked immunosorbent assay (MAC-ELISA) in cerebrospinal fluid (CSF) and serum is the recommended method of laboratory diagnosis, but specificity of JEV MAC-ELISA can be low due to cross-reactivity. To increase the specificity of the commercially available JE Detect™ MAC-ELISA (JE Detect), a differential testing algorithm was developed in which samples tested by JE Detect with positive results were subsequently tested by the DEN Detect™ MAC-ELISA (DEN Detect) kit, and results of both tests were used to make the final interpretation. The testing algorithm was evaluated with a reference panel of serum and CSF samples submitted for confirmatory testing. In serum, the false Japanese encephalitis (JE) positive rate was reduced, but sequential testing in CSF resulted in reduced JE specificity, as true JEV+ CSF samples had positive results by both JE Detect and DEN Detect and were classified as JE− (dengue virus [DENV]+). Differential diagnosis of JE by sequential testing with JE Detect and DEN Detect increased specificity for JE in serum, but more data with CSF is needed to make a final determination on the usefulness of this testing algorithm for CSF. PMID:26856911

  17. [Surgical treatment for third-grade fracture of the dens of the second cervical vertebra with transdental posterior subluxation].

    PubMed

    Dzukaev, D N; Dreval', O N; Sidorenko, V V; Siviakov, A A; Khoreva, N E

    2007-01-01

    The paper describes a case of successful treatment in a patient with third-grade fracture of the dens of the second cervical vertebra with transdental posterior subluxation. According to the treatment policy chosen, posterior upper cervical spine stabilization and anterior upper spinal cord decompression that was supplemented by anterior cervical spondylodesis were performed in the early period.

  18. Five root canals in peg lateral incisor with dens invaginatus: A case report with new nomenclature for the five canals

    PubMed Central

    Jaikailash, Shanmugam; Kavitha, Mahendran; Ranjani, Muthukrishnan Sudharshana; Saravanan, Balasubramaniam

    2014-01-01

    This case report describes endodontic treatment completed in a peg-shaped maxillary lateral incisor, with single root and five root canals of which, one is due to dens invaginatus. Cone beam computed tomogram scanning confirmed the unique morphology of the tooth. New nomenclature for the five canals is proposed. PMID:25125854

  19. Temperature controls seed germination and dormancy in the European woodland herbaceous perennial Erythronium dens-canis (Liliaceae).

    PubMed

    Mondoni, A; Rossi, G; Probert, R

    2012-05-01

    We examined the germination ecology and the temperature requirements for germination of Erythronium dens-canis, under both outdoor and laboratory conditions. E. dens-canis is a spring flowering woodland geophyte widely distributed across Europe. Germination phenology, including embryo development and radicle and cotyledon emergence, were investigated in a natural population growing in Northern Italy. Immediately after harvest, seeds of E. dens-canis were either sown on agar in the laboratory under simulated seasonal temperatures or placed in nylon mesh sachets and buried in the wild. Embryos, undifferentiated at the time of seed dispersal, grew during summer and autumn conditions in the laboratory and in the wild, culminating in radicle emergence in winter when temperatures fell to ≈ 5 °C. Emergence of cotyledons did not occur immediately after radicle emergence, but was delayed until the end of winter. Laboratory experiments showed that temperature is the main factor controlling dormancy and germination, with seeds becoming non-dormant only when given warmth, followed by cold stratification. Unlike seeds of E. dens-canis that germinate in winter, in other Erythronium species radicle emergence occurs in autumn, while in some it is delayed until seeds are transferred from winter to spring conditions. Our results suggest that there is genetic and environmental control of the expression of seed dormancy amongst Erythronium species, which is related to local climate.

  20. Distribution of dens used by radiocollared San Joaquin kit fox on Naval Petroleum Reserve No. 1, Kern County, California, 1980-1987

    SciTech Connect

    O'Farrell, T.P.; Tabor, S.P.; Kato, T.T.

    1987-09-01

    Locations of 945 dens used by radiocollared San Joaquin kit foxes (Vulpes macrotis mutica) on or adjacent to the US Department of Energy's Naval Petroleum Reserve No. 1 (NPR-1) in western Kern County, California between 1980-1987 were recorded on maps and stored within a computer-compatible data base. Most (516 of 887) typical subterranean dens of this endangered species were found in undeveloped portions of 65 sections, but most (41 of 58) atypical dens (dens in man-made structures) were found in developed portions of 26 sections. Program managers can plan construction, maintenance, and operational activities on NPR-1 in ways that avoid potential conflicts with the conservation of kit fox dens by using the section maps provided in this report or by accessing the computerized data base through the Endangered Species Contractor, EG and G Energy Measurements, Inc. 20 refs., 3 figs, 1 tab.

  1. Vector competence of Aedes albopictus and Aedes aegypti (Diptera: Culicidae) for DEN2-43 and New Guinea C virus strains of dengue 2 virus.

    PubMed

    Guo, Xiao-Xia; Zhu, Xiao-Juan; Li, Chun-Xiao; Dong, Yan-De; Zhang, Ying-Mei; Xing, Dan; Xue, Rui-De; Qin, Cheng-Feng; Zhao, Tong-Yan

    2013-12-01

    The vector competence of Aedes albopictus and Aedes aegypti with regard to DEN2-43 and New Guinea C (NGC) virus strains of Dengue 2 viruses was assessed and compared. The infection and dissemination rate and distribution of DEN2-43 antigens in orally infected Ae. albopictus was investigated using the reverse transcription polymerase chain reaction and an indirect immunofluorescence assay. To better understand the initial infection, dissemination and transmission of these viral strains in vector mosquitoes, Ae. albopoictus and Ae. aegypti were fed an artificial blood meal containing either the DEN2-43 or NGC strain. There was no significant difference in the infection and dissemination rates of DEN2-43 and NGC virus strains in Ae. albopictus, however, Ae. aegypti was more susceptible to infection by NGC than DEN2-43 vrius strain. Ae. albopictus mosquitoes infected with the NGC strain developed a higher percentage of midgut infections than those infected with the DEN2-43 strain (t=2.893, df=7, P=0.024). Approximately 26.7% of midgut samples were positive for the NGC antigen 5 days after infection, and 80% of mosquitoes had infected midgets after 15 days. The NGC antigen first became evident in mosquito salivary glands on Day 5, and 40% of mosquitoes had infected salivary by Day 9. In contrast, the DEN2-43 antigen first became evident in salivary glands on Day 7. The infection rate of NGC and DEN2-43 virus strains in salivary glands were similar. These results indicate that Ae. albopictus and Ae. aegypti are moderately competent vectors for the DEN2-43 virus, which could provide basic data for the epidemiology study of dengue fever in China.

  2. Dens evaginatus: review of the literature and report of several clinical cases.

    PubMed

    McCulloch, K J; Mills, C M; Greenfeld, R S; Coil, J M

    1998-02-01

    Dens evaginatus (DE) presents as an innocuous looking tubercle of enamel on the occlusal surface of a tooth, most commonly a bicuspid. Problems can arise when the tubercle is either worn, ground, or fractured off, resulting in pulpal exposure and possible loss of vitality of the tooth. Dentists who perform orthodontic treatment should be aware of this dental anomaly, which occurs in at least two per cent of the Asian and Native Indian populations. Bicuspid extraction cases should involve the extraction of the anomalous premolars rather than the normal ones. In addition, the dentist should be mindful of occlusal changes that may occur during treatment or occlusal equilibration, both of which can jeopardize the vitality of teeth with DE. Pulp capping or partial pulpotomy has been postulated to be one of the most reliable forms of vital tooth treatment when pulp exposure is encountered following the sterile removal of the tubercle. When pulp exposure is not encountered, preventive resin composite sealing of the dentin or class I amalgam cavity preparation seems to be the treatment of choice.

  3. Design und Analyse elektrisch kleiner Antennen für den Einsatz in UHF RFID Transpondern

    NASA Astrophysics Data System (ADS)

    Herschmann, R.; Camp, M.; Eul, H.

    2006-09-01

    RFID Systeme werden seit Anfang der neunziger Jahre mit stetig zunehmender Verbreitung im Bereich der automatischen Produktidentifikation, der Diebstahlsicherung (EAS, Electronic Article Surveillance) und für automatische Zutrittskontrollsysteme eingesetzt. Objekte werden hierzu mit einem Transponder ausgestattet, der aus einer Antenne und einem Chip auf einem Trägermaterial besteht. Von großem Interesse ist die Entwicklung und Optimierung von passiven Transpondern für den Einsatz in UHF RFID Systemen. Diese Transponder beziehen die Energie zum Betrieb des Chips aus dem elektromagnetischen Feld einer Schreib-Leseeinheit. Hierfür ist neben der Anpassung der Eingangsimpedanz der Antenne an die Chipimpedanz auch eine möglichst hohe Bandbreite der Antennen wünschenswert, um die Funktion des Transponders bei Schwankungen der Chipimpedanz und variablen Umgebungsparametern zu gewährleisten. Der aus Platzgründen notwendige Einsatz elektrisch kleiner Antennen bedingt eine möglichst optimale Ausnutzung der zur Verfügung stehenden Fläche auf dem Trägermaterial zur Aufnahme der Antenne. Die vorliegende Arbeit beschreibt ein Verfahren zur Analyse und Synthese neuartiger Antennendesigns auf der Basis parametrisierter meandrierter, spiralförmiger und logarithmisch periodischer Dipole.

  4. Recombinant soluble gp130 protein reduces DEN-induced primary hepatocellular carcinoma in mice

    PubMed Central

    Hong, Jing; Wang, Hang; Shen, Guoying; Lin, Da; Lin, Yanxue; Ye, Nanhui; Guo, Yashan; Li, Qiaoling; Ye, Nanhui; Deng, Chengjun; Meng, Chun

    2016-01-01

    IL-6 (interleukin 6) plays an important role in the development and growth of hepatocellular carcinoma (HCC) via both classic signaling and trans-signaling pathways. Soluble gp130 (sgp130) is known to be a natural inhibitor of the trans-signaling pathway. In the present study, our goal was to investigate whether recombinant sgp130 could suppress the initiation and progression of HCC in mouse models. Our results demonstrate that sgp130 induced an apoptosis of HepG2 cells and inhibited the clonogenicity of HepG2 in vitro. Moreover, the IL-6 trans-signaling pathway is significantly suppressed by sgp130 as reflected by the decrease in the level of STAT3 phosphorylation and other inflammatory factors both in vitro and in vivo. In the DEN-induced HCC mouse model, intravenous injection of sgp130 attenuated hepatic fibrosis at 16 weeks and reduced the initiation and progression of primary HCC at 36 weeks. Furthermore, our results also demonstrate that intravenous administration of sgp130 significantly suppressed the growth and metastasis of xenograft human HCC in NOD/SCID mice. PMID:27080032

  5. A comprehensive photometric study of dynamically evolved small van den Bergh-Hagen open clusters

    NASA Astrophysics Data System (ADS)

    Piatti, Andrés E.

    2016-12-01

    We present results from Johnson UBV, Kron-Cousins RI and Washington CT1T2 photometries for seven van den Bergh-Hagen (vdBH) open clusters, namely, vdBH 1, 10, 31, 72, 87, 92, and 118. The high-quality, multiband photometric data sets were used to trace the cluster stellar density radial profiles and to build colour-magnitude diagrams and colour-colour diagrams from which we estimated their structural parameters and fundamental astrophysical properties. The clusters in our sample cover a wide age range, from ˜60 Myr up to 2.8 Gyr, are of relatively small size (˜1-6 pc) and are placed at distances from the Sun which vary between 1.8 and 6.3 kpc, respectively. We also estimated lower limits for the cluster present-day masses as well as half-mass relaxation times (tr). The resulting values in combination with the structural parameter values suggest that the studied clusters are in advanced stages of their internal dynamical evolution (age/tr ˜ 20-320), possibly in the typical phase of those tidally filled with mass segregation in their core regions. Compared to open clusters in the solar neighbourhood, the seven vdBH clusters are within more massive (˜80-380 M⊙), with higher concentration parameter values (c ˜ 0.75-1.15) and dynamically evolved ones.

  6. Polar bear mother-offspring interactions in maternity dens in captivity.

    PubMed

    van Gessel, Chad

    2015-01-01

    Two female polar bears at Dierenrijk Zoo in the Netherlands were monitored at their maternity den one day before the birth of their cubs and three days postpartum. Each bear was monitored for 96 hr to document behaviour and vocalisations. The goal was to obtain insight into the differences between the mother that lost her litter and the other that successfully reared her cubs. Six groups of cub vocalisations were identified: Comfort, Discomfort, Distress, Nursing Attempts, Nursing, and No Vocalisation. Maternal vocalisations were split into three groups: Calm, Grooming, and Stress. Maternal behaviours were also split into three groups: Active, Rest, and Stress. The unsuccessful mother produced more stress vocalisations before and during the birth of her cub, whereas the successful mother appeared less stressed. Vocalisations indicate that the cub that died tried to nurse but was unsuccessful. The unsuccessful mother showed less stress as her cub got weaker and vocalised less. From this I suggest that maternal stress was a factor in cub mortality.

  7. Conservative management of dens evaginatus and attached supernumerary tooth/odontome in mandibular premolar with dual radiolucencies

    PubMed Central

    Shah, Naseem; Jadhav, Ganesh Ranganath; Mittal, Priya; Logani, Ajay

    2015-01-01

    Recently, an innovative, nonsurgical regenerative endodontic treatment protocol “SealBio” was introduced to manage mature nonvital permanent teeth with periapical lesions. This paper explains the management of an unusual case of dens evaginatus and an attached supernumerary tooth/an odontome associated with two distinct radiolucencies in a mandibular premolar with “SealBio” technique and discusses the various hypotheses on the pathogenesis of unusual malformation and associated pericervical cyst-like radiolucency in the involved tooth. PMID:26604586

  8. Regenerative Endodontic Treatment of an Infected Immature Dens Invaginatus with the Aid of Cone-Beam Computed Tomography

    PubMed Central

    Kaya-Büyükbayram, Işıl; Özalp, Şerife; Aydemir, Seda

    2014-01-01

    Dens invaginatus is a developmental anomaly that results in an enamel-lined cavity intruding into the crown or root before the mineralization phase. This report presents regenerative endodontic treatment of a necrotic immature tooth with Oehler's type III dens invaginatus of a nine-year-old female patient. A diagnosis of dens invaginatus (Oehler's type III) and a large periapical lesion was established with the aid of cone-beam computed tomography (CBCT). In the presented case contrary to the classic revascularization protocol, mechanical instrumentation was performed which apparently did not interfere with the regeneration process. After mechanical instrumentation of the invaginated canal by manual K-files, the invaginated canal space was disinfected by triple antibiotic paste followed by blood clot induction from the periapical tissues and the placement of mineral trioxide aggregate. At one-year follow-up, the tooth remained clinically asymptomatic. Radiographic examination revealed complete healing of the periapical lesion. At the 20-month follow-up, the radiographic examination also showed that the open apex was closed and the walls of the root canal were thickened. PMID:25530890

  9. Steppe lion remains imported by Ice Age spotted hyenas into the Late Pleistocene Perick Caves hyena den in northern Germany

    NASA Astrophysics Data System (ADS)

    Diedrich, Cajus G.

    2009-05-01

    Upper Pleistocene remains of the Ice Age steppe lion Panthera leo spelaea (Goldfuss, 1810) have been found in the Perick Caves, Sauerland Karst, NW Germany. Bones from many hyenas and their imported prey dating from the Lower to Middle Weichselian have also been recovered from the Perick Cave hyena den. These are commonly cracked or exhibit deep chew marks. The absence of lion cub bones, in contrast to hyena and cave bear cub remains in the Perick Caves, and other caves of northern Germany, excludes the possibility that P. leo spelaea used the cave for raising cubs. Only in the Wilhelms Cave was a single skeleton of a cub found in a hyena den. Evidence of the chewing, nibbling and cracking of lion bones and crania must have resulted from the importation and destruction of lion carcasses (4% of the prey fauna). Similar evidence was preserved at other hyena den caves and open air sites in Germany. The bone material from the Perick and other Central European caves points to antagonistic hyena and lion conflicts, similar to clashes of their modern African relatives.

  10. Korrelationsstatistischer Vergleich zweier Schulleistungstests fur den Unterricht in Englisch an Hauptschulen (Comparison by Statistical Correlation of Two English Achievement Tests for Intermediate Schools)

    ERIC Educational Resources Information Center

    Koch, Holger; Scheibner-Herzig, Gudrun

    1971-01-01

    Expanded version of a lecture given at a meeting of the Teachers of Modern Languages in Colleges of Education (Tagung der Fachdidaktiker fur neuere Sprachen an den Padagogischen Hochschulen), October 1, 1970 in Luneburg, West Germany. (RS)

  11. [Co-infection by Chikungunya virus (CHIK-V) and dengue virus (DEN-V) during a recent outbreak in Cali, Colombia: Report of a fatal case].

    PubMed

    Rosso, Fernando; Pacheco, Robinson; Rodríguez, Sarita; Bautista, Diego

    2016-08-01

    The recent outbreaks of Chikungunya (CHIK-V) virus in endemic areas of dengue (DEN-V) could increase the risk of co-infection. CHIK infection has been considered not severe and with very unusual mortality, however DEN is associated with severe manifestations and increased mortality. Little is known about coinfection. It is possible that co-infection could generate severe cases. We present a case report of co-infection DEN-V -3 and CHIK-V in an elderly patient who developed acute renal failure, dengue shock syndrome (DSS), progresses to multiple organ failure and died. With the recent emergence of CHIK-V in Colombia, the possibility of co-infection with DEN-V should be suspected, especially in severe cases.

  12. Kernschmelze Der nachhaltige Einfluss von Nuklearwaffen auf Politik und Wirtschaft

    NASA Astrophysics Data System (ADS)

    Greiner, Bernd

    "Was sollen wir von einer Kultur halten, der die Ethik stets als wesentliches Element des menschlichen Lebens galt, die aber - außer in fachlicher oder spieltheoretischer Terminologie - nicht in der Lage war, über die Möglichkeit zu sprechen, nahezu alle Menschen zu töten?" Der Fragesteller gehört zu den berühmtesten Physikern des 20. Jahrhunderts und zu den nach wie vor Umstrittensten. über ihn wurde in den 1960er Jahren ein international viel beachtetes Theaterstück geschrieben, vor wenigen Jahren gar eine Oper.

  13. Mutations in SCARF2 Are Responsible for Van Den Ende-Gupta Syndrome

    PubMed Central

    Anastasio, Natascia; Ben-Omran, Tawfeg; Teebi, Ahmad; Ha, Kevin C.H.; Lalonde, Emilie; Ali, Rehab; Almureikhi, Mariam; Der Kaloustian, Vazken M.; Liu, Junhui; Rosenblatt, David S.; Majewski, Jacek; Jerome-Majewska, Loydie A.

    2010-01-01

    Van Den Ende-Gupta syndrome (VDEGS) is an extremely rare autosomal-recessive disorder characterized by distinctive craniofacial features, which include blepharophimosis, malar and/or maxillary hypoplasia, a narrow and beaked nose, and an everted lower lip. Other features are arachnodactyly, camptodactyly, peculiar skeletal abnormalities, and normal development and intelligence. We present molecular data on four VDEGS patients from three consanguineous Qatari families belonging to the same highly inbred Bedouin tribe. The patients were genotyped with SNP microarrays, and a 2.4 Mb homozygous region was found on chromosome 22q11 in an area overlapping the DiGeorge critical region. This region contained 44 genes, including SCARF2, a gene that is expressed during development in a number of mouse tissues relevant to the symptoms described above. Sanger sequencing identified a missense change, c.773G>A (p.C258Y), in exon 4 in the two closely related patients and a 2 bp deletion in exon 8, c.1328_1329delTG (p.V443DfsX83), in two unrelated individuals. In parallel with the candidate gene approach, complete exome sequencing was used to confirm that SCARF2 was the gene responsible for VDEGS. SCARF2 contains putative epidermal growth factor-like domains in its extracellular domain, along with a number of positively charged residues in its intracellular domain, indicating that it may be involved in intracellular signaling. However, the function of SCARF2 has not been characterized, and this study reports that phenotypic effects can be associated with defects in the scavenger receptor F family of genes. PMID:20887961

  14. Mutations in SCARF2 are responsible for Van Den Ende-Gupta syndrome.

    PubMed

    Anastasio, Natascia; Ben-Omran, Tawfeg; Teebi, Ahmad; Ha, Kevin C H; Lalonde, Emilie; Ali, Rehab; Almureikhi, Mariam; Der Kaloustian, Vazken M; Liu, Junhui; Rosenblatt, David S; Majewski, Jacek; Jerome-Majewska, Loydie A

    2010-10-08

    Van Den Ende-Gupta syndrome (VDEGS) is an extremely rare autosomal-recessive disorder characterized by distinctive craniofacial features, which include blepharophimosis, malar and/or maxillary hypoplasia, a narrow and beaked nose, and an everted lower lip. Other features are arachnodactyly, camptodactyly, peculiar skeletal abnormalities, and normal development and intelligence. We present molecular data on four VDEGS patients from three consanguineous Qatari families belonging to the same highly inbred Bedouin tribe. The patients were genotyped with SNP microarrays, and a 2.4 Mb homozygous region was found on chromosome 22q11 in an area overlapping the DiGeorge critical region. This region contained 44 genes, including SCARF2, a gene that is expressed during development in a number of mouse tissues relevant to the symptoms described above. Sanger sequencing identified a missense change, c.773G>A (p.C258Y), in exon 4 in the two closely related patients and a 2 bp deletion in exon 8, c.1328_1329delTG (p.V443DfsX83), in two unrelated individuals. In parallel with the candidate gene approach, complete exome sequencing was used to confirm that SCARF2 was the gene responsible for VDEGS. SCARF2 contains putative epidermal growth factor-like domains in its extracellular domain, along with a number of positively charged residues in its intracellular domain, indicating that it may be involved in intracellular signaling. However, the function of SCARF2 has not been characterized, and this study reports that phenotypic effects can be associated with defects in the scavenger receptor F family of genes.

  15. A Probabilistic Wake Vortex Lateral Transport Model Using Data from SFO and DEN

    NASA Technical Reports Server (NTRS)

    Mellman, George R.; Delisi, Donald P.

    2008-01-01

    In a previous report, we considered the behavior of the lateral position of vortices as a function of time after vortex formation for Out of Ground Effects (OGE) data for aircraft landing at San Francisco International Airport (SFO). We quantified the spread in lateral position as a function of time and examined how predictable lateral position is under a variety of assumptions. The combination of spread and predictability allowed us to derive probability distribution functions (PDFs) for lateral position given observed crosswind (CW) velocities. In this study, we examine the portability of these PDFs with respect to other landing sites. To this end, we consider OGE data obtained by the Federal Aviation Administration for landings at Denver International Airport (DEN) between 04/05/2006 and 06/03/2006. We consider vortices from both B733 (Boeing 737 models 200-500) and B757 (Boeing 757) aircraft. The data set contains 635 B733 landings and 506 B757 landings. The glide slope altitude for these measurements was 280 m, determined by the average initial vortex observation adjusted for a 3-second delay in the initial observation. The comparable SFO altitude was 158 m. We note that the principal mechanism for lateral transport in the OGE regime is advection by the ambient wind. This implies that a simple crosswind correction may be effective in explaining much of the variation in the lateral transport data. In this study, we again consider the use of ASOS data and average Lidar crosswind data over the vortex altitude range to predict vortex location as a function of time.

  16. ‘Neanderthal bone flutes’: simply products of Ice Age spotted hyena scavenging activities on cave bear cubs in European cave bear dens

    PubMed Central

    Diedrich, Cajus G.

    2015-01-01

    Punctured extinct cave bear femora were misidentified in southeastern Europe (Hungary/Slovenia) as ‘Palaeolithic bone flutes’ and the ‘oldest Neanderthal instruments’. These are not instruments, nor human made, but products of the most important cave bear scavengers of Europe, hyenas. Late Middle to Late Pleistocene (Mousterian to Gravettian) Ice Age spotted hyenas of Europe occupied mainly cave entrances as dens (communal/cub raising den types), but went deeper for scavenging into cave bear dens, or used in a few cases branches/diagonal shafts (i.e. prey storage den type). In most of those dens, about 20% of adult to 80% of bear cub remains have large carnivore damage. Hyenas left bones in repeating similar tooth mark and crush damage stages, demonstrating a butchering/bone cracking strategy. The femora of subadult cave bears are intermediate in damage patterns, compared to the adult ones, which were fully crushed to pieces. Hyenas produced round–oval puncture marks in cub femora only by the bone-crushing premolar teeth of both upper and lower jaw. The punctures/tooth impact marks are often present on both sides of the shaft of cave bear cub femora and are simply a result of non-breakage of the slightly calcified shaft compacta. All stages of femur puncturing to crushing are demonstrated herein, especially on a large cave bear population from a German cave bear den. PMID:26064624

  17. 78 FR 32387 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... 4010, FR 4011, FR 4012, FR 4017, FR 4019, or FR 4023 by any of the following methods: Agency Web Site... curing the deficiencies and to execute a formal cure agreement with the Federal Reserve.\\5\\ \\4\\ 12...

  18. State of Digital Education Options in the areas of Medical Terminology and the History, Theory and Ethics of Medicine.

    PubMed

    Schochow, Maximilian; Steger, Florian

    2015-01-01

    Hintergrund: In Deutschland haben viele Einrichtungen für die Bereiche Geschichte, Theorie und Ethik der Medizin E-Learning-Angebote produziert, die auf unterschiedlichen Lernplattformen basieren (LMS) und spezifisch auf die jeweilige curriculare Präsenzlehre zugeschnitten sind. Bisher existieren keine validen Daten darüber, welche Einrichtungen E-Learning-Angebote bereitstellen und welche Formen des E-Learning diese anbieten.Methoden: Von den 31 deutschen Einrichtungen für Geschichte, Theorie und Ethik der Medizin, die gefragt wurden, den Fragebogen auszufüllen, haben 30 geantwortet, was einer Rücklaufquote von 97% entspricht. Die telefonische Befragung fand zwischen Juli und August 2012 statt.Ergebnisse: Der Einsatz digitaler interaktiver Lehrmaterialien, die webbasiert den Studierenden zur Verfügung gestellt werden, hat in den vergangenen Jahren eine Konjunktur an deutschen Einrichtungen für die Bereiche Geschichte, Theorie und Ethik der Medizin erfahren. Dieser Trend wird sich weiter fortsetzen, da mehr als die Hälfte (67%) der Einrichtungen ihre bisherigen E-Learning-Angebote ausbauen will. In den vergangenen Jahren sind vor allem Angebote für Medizinische Terminologie entstanden. Viele Einrichtungen möchten künftig ihre Angebote für Medizinische Terminologie weiterentwickeln. Insgesamt wurden die E-Learning-Angebote von den Studierenden sehr gut aufgenommen. 57% der Einrichtungen gaben an, dass 90-100% der Studierenden die Angebote regelmäßig nutzen.Schlussfolgerungen: Dieser Artikel diskutiert die Ergebnisse einer umfangreichen empirischen Studie über E-Learning. Er zeigt den Rahmen auf, in dem deutsche Einrichtungen vorhaben, ihre E-Learning-Optionen in der Zukunft auszuweiten. Schließlich werden spezifische Vorschläge für die Zusammenarbeit unter den Einrichtungen (nicht nur online) gemacht, deren Ziel es ist, Synergien im Bereich E-Learning zu erzeugen.

  19. Dose response for TCDD promotion of hepatocarcinogenesis in rats initiated with DEN: histologic, biochemical, and cell proliferation endpoints.

    PubMed Central

    Maronpot, R R; Foley, J F; Takahashi, K; Goldsworthy, T; Clark, G; Tritscher, A; Portier, C; Lucier, G

    1993-01-01

    The present study examines the dose-response relationship for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) promotion of histologic and biochemical parameters by using a two-stage model for hepatocarcinogenesis in female Sprague-Dawley rats initiated with a single intraperitoneal dose of 175 mg of diethylnitrosamine (DEN)/kg body weight at 70 days of age. Starting 2 weeks after initiation, treatment groups of 8-10 rats were given TCDD by gavage in corn oil once every 2 weeks for 30 weeks. Doses were 3.5, 10.7, 35.7, and 125 ng TCDD/kg body weight/day. A significant body weight reduction was present in the noninitiated group that received 125 ng TCDD. Relative liver weight was statistically increased in initiated rats treated with > or = 10.7 ng TCDD and in noninitiated rats treated with > or = 35.7 ng TCDD. Histopathologic evidence of cytotoxicity was dose-related in all TCDD-treated groups. There was a statistically significant dose response in the bromodeoxyuridine (BrdU) S-phase labeling index (LI) in the DEN-initiated rats (p < 0.01) and a marginally significant trend in the saline-treated rats (p = 0.10), but proliferating cell nuclear antigen S-phase LI and growth fraction within altered hepatic foci showed no increase. Among the DEN-initiated groups there was a significant increase in glutathione S-transferase altered hepatic foci stereological parameters in the 125 ng TCDD group. This study demonstrates that dose-response relationships for TCDD's effects on cell proliferation growth of altered hepatic foci are different from previously reported effects on P450 gene expression, indicating that different biological or biochemical responses may exhibit different dose-response relationships.(ABSTRACT TRUNCATED AT 250 WORDS) Images Figure 1. Figure 1. Figure 1. Figure 1. Figure 1. Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. PMID:8143597

  20. Dose response for TCDD promotion of hepatocarcinogenesis in rats initiated with DEN: histologic, biochemical, and cell proliferation endpoints.

    PubMed

    Maronpot, R R; Foley, J F; Takahashi, K; Goldsworthy, T; Clark, G; Tritscher, A; Portier, C; Lucier, G

    1993-12-01

    The present study examines the dose-response relationship for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) promotion of histologic and biochemical parameters by using a two-stage model for hepatocarcinogenesis in female Sprague-Dawley rats initiated with a single intraperitoneal dose of 175 mg of diethylnitrosamine (DEN)/kg body weight at 70 days of age. Starting 2 weeks after initiation, treatment groups of 8-10 rats were given TCDD by gavage in corn oil once every 2 weeks for 30 weeks. Doses were 3.5, 10.7, 35.7, and 125 ng TCDD/kg body weight/day. A significant body weight reduction was present in the noninitiated group that received 125 ng TCDD. Relative liver weight was statistically increased in initiated rats treated with > or = 10.7 ng TCDD and in noninitiated rats treated with > or = 35.7 ng TCDD. Histopathologic evidence of cytotoxicity was dose-related in all TCDD-treated groups. There was a statistically significant dose response in the bromodeoxyuridine (BrdU) S-phase labeling index (LI) in the DEN-initiated rats (p < 0.01) and a marginally significant trend in the saline-treated rats (p = 0.10), but proliferating cell nuclear antigen S-phase LI and growth fraction within altered hepatic foci showed no increase. Among the DEN-initiated groups there was a significant increase in glutathione S-transferase altered hepatic foci stereological parameters in the 125 ng TCDD group. This study demonstrates that dose-response relationships for TCDD's effects on cell proliferation growth of altered hepatic foci are different from previously reported effects on P450 gene expression, indicating that different biological or biochemical responses may exhibit different dose-response relationships.(ABSTRACT TRUNCATED AT 250 WORDS)

  1. Geothermal Project Den Haag - 3-D models for temperature prediction and reservoir characterization

    NASA Astrophysics Data System (ADS)

    Mottaghy, D.; Pechnig, R.; Willemsen, G.; Simmelink, H. J.; Vandeweijer, V.

    2009-04-01

    In the framework of the "Den Haag Zuidwest" geothermal district heating system a deep geothermal installation is projected. The target horizon of the planned doublet is the "Delft sandstone" which has been extensively explored for oil- and gas reservoirs in the last century. In the target area, this upper Jurassic sandstone layer is found at a depth of about 2300 m with an average thickness of about 50 m. The study presented here focuses on the prediction of reservoir temperatures and production behavior which is crucial for planning a deep geothermal installation. In the first phase, the main objective was to find out whether there is a significant influence of the 3-dimensional structures of anticlines and synclines on the temperature field, which could cause formation temperatures deviating from the predicted extrapolated temperature data from oil and gas exploration wells. To this end a regional model was set up as a basis for steady state numerical simulations. Since representative input parameters are decisive for reliable model results, all available information was compiled: a) the subsurface geometry, depth and thickness of the stratigraphic layers known from seismic data sets 2) borehole geophysical data and c) geological and petrographical information from exploration wells. In addition 50 cuttings samples were taken from two selected key wells in order to provide direct information on thermal properties of the underlying strata. Thermal conductivity and rock matrix density were measured in the laboratory. These data were combined with a petrophysical log analysis (Gamma Ray, Sonic, Density and Resistivity), which resulted in continuous profiles of porosity, effective thermal conductivity and radiogenetic heat production. These profiles allowed to asses in detail the variability of the petrophysical properties with depth and to check for lateral changes between the wells. All this data entered the numerical simulations which were performed by a 3-D

  2. An Immature Type II Dens Invaginatus in a Mandibular Lateral Incisor with Talon's Cusp: A Clinical Dilemma to Confront

    PubMed Central

    Singal, Deepa; Giri, K. Y.; Keerthi, S. Sruthi

    2014-01-01

    Dens invaginatus (DI) is a malformation of teeth probably resulting from an infolding of the dental papilla during tooth development. DI is classified as type I, II, and III by Oehlers depending on the severity of malformation. The maxillary lateral incisor is the most commonly affected tooth. Structural defects do exist in the depth of the invagination pits, and as a consequence, the early development of caries and the subsequent necrosis of the dental pulp, as well as abscess and cyst formation are clinical implications associated with DI. Occasionally, we can see more than one developmental anomaly occurring in a single tooth. In such cases it becomes important to identify the anomalies and initiate a proper treatment plan for good prognosis. In this paper, an unusual case of DI which clinically presented as a huge talons cusp affecting a mandibular lateral incisor tooth is described. This case report illustrates grinding of the talons cusp followed by nonsurgical endodontic management of dens invaginatus type II with an immature apex and periapical lesions, in which Mineral Trioxide Aggregate (MTA) shows a complete periapical healing with bone formation at the site of the lesions. PMID:24660071

  3. Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation

    PubMed Central

    Zhong, Shuping

    2013-01-01

    The products of Pol III genes (RNA polymerase III-dependent genes), such as tRNAs and 5S rRNA, are elevated in both transformed and tumor cells suggesting that they play a crucial role in tumorigenesis. An increase in Brf1 (TFIIIB-related factor 1), a subunit of TFIIIB, augments Pol III gene transcription and is sufficient for cell transformation and tumor formation. We have demonstrated that enhancement of Brf1 and Pol III gene expression is associated with the occurrences of hepatocellular carcinoma (HCC) in mice. This suggests that Brf1 may be a key molecule during HCC development. Diethylnitrosamine (DEN), a chemical carcinogen, has been used to induce HCC in rodents. To determine the role of Brf1 and the epigenetic-regulating events in cell proliferation and transformation, hepatocytes were treated with DEN. The results indicate that DEN increases proliferation and transformation of AML-12 cells. DEN enhanced Brf1 expression and tRNALeu and 5S rRNA transcription, as well as H3S10ph (phosphorylation of histone H3 serine 10). Interestingly, DEN-induced Pol III gene transcription and H3S10ph in tumor cells of liver are significantly higher than in non-tumor cells. Inhibition of H3S10ph by H3S10A attenuates the induction of Brf1 and Pol III genes. Further analysis indicates that H3S10ph occupies the promoters of Brf1 and Pol III genes to modulate their expression. Blocking H3S10ph represses cell proliferation and transformation. These results demonstrate that DEN induces H3S10ph, which mediate Brf1 expression, including but not limited Brf1-dependent genes, to upregulate Pol III gene transcription, resulting in an increase in cell proliferation and transformation. PMID:23774401

  4. Magnetic nanoparticles are highly toxic to chloroquine-resistant Plasmodium falciparum, dengue virus (DEN-2), and their mosquito vectors.

    PubMed

    Murugan, Kadarkarai; Wei, Jiang; Alsalhi, Mohamad Saleh; Nicoletti, Marcello; Paulpandi, Manickam; Samidoss, Christina Mary; Dinesh, Devakumar; Chandramohan, Balamurugan; Paneerselvam, Chellasamy; Subramaniam, Jayapal; Vadivalagan, Chithravel; Wei, Hui; Amuthavalli, Pandiyan; Jaganathan, Anitha; Devanesan, Sandhanasamy; Higuchi, Akon; Kumar, Suresh; Aziz, Al Thabiani; Nataraj, Devaraj; Vaseeharan, Baskaralingam; Canale, Angelo; Benelli, Giovanni

    2017-02-01

    A main challenge in parasitology is the development of reliable tools to prevent or treat mosquito-borne diseases. We investigated the toxicity of magnetic nanoparticles (MNP) produced by Magnetospirillum gryphiswaldense (strain MSR-1) on chloroquine-resistant (CQ-r) and sensitive (CQ-s) Plasmodium falciparum, dengue virus (DEN-2), and two of their main vectors, Anopheles stephensi and Aedes aegypti, respectively. MNP were studied by Fourier-transform infrared spectroscopy and transmission electron microscopy. They were toxic to larvae and pupae of An. stephensi, LC50 ranged from 2.563 ppm (1st instar larva) to 6.430 ppm (pupa), and Ae. aegypti, LC50 ranged from 3.231 ppm (1st instar larva) to 7.545 ppm (pupa). MNP IC50 on P. falciparum were 83.32 μg ml(-1) (CQ-s) and 87.47 μg ml(-1) (CQ-r). However, the in vivo efficacy of MNP on Plasmodium berghei was low if compared to CQ-based treatments. Moderate cytotoxicity was detected on Vero cells post-treatment with MNP doses lower than 4 μg ml(-1). MNP evaluated at 2-8 μg ml(-1) inhibited DEN-2 replication inhibiting the expression of the envelope (E) protein. In conclusion, our findings represent the first report about the use of MNP in medical and veterinary entomology, proposing them as suitable materials to develop reliable tools to combat mosquito-borne diseases.

  5. 78 FR 79481 - Summary of Commission Practice Relating to Administrative Protective Orders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... actions in response to violations of Commission APOs and the 24-hour rule. See 56 FR 4846 (February 6, 1991); 57 FR 12335 (April 9, 1992); 58 FR 21991 (April 26, 1993); 59 FR 16834 (April 8, 1994); 60 FR 24880 (May 10, 1995); 61 FR 21203 (May 9, 1996); 62 FR 13164 (March 19, 1997); 63 FR 25064 (May 6,...

  6. Protective Effect of Ethanolic Extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA Induced Liver Necrosis in Wistar Albino Rats

    PubMed Central

    2014-01-01

    This study is an attempt to evaluate the hepatoprotective activity of Tabernaemontana divaricata against DEN and Fe NTA induced liver necrosis in rats. Ethanolic extract of the whole plant of Tabernaemontana divaricata at doses of 200 and 400 mg/kg body weight and 5-fluorouracil (standard drug) was orally administered to male Wistar Albino rats once daily for 24 weeks, simultaneously treated with the carcinogen DEN and Fe NTA. In simultaneously treated animals, the plant extract significantly decreased the levels of uric acid, bilirubin, AST, ALT, and ALP in serum and increased the levels of liver marker enzymes in liver. Treatment with the extracts resulted in a significant increase in the levels of antioxidants accompanied by a marked reduction in the levels of malondialdehyde when compared to DEN and Fe NTA treated group. When compared with 200 mg/kg bw rats, 400 mg/kg bw rats and 5-fluorouracil treated rats showed better results in all the parameters. The histopathological studies confirmed the protective effects of extract against DEN and Fe NTA induced liver necrosis. Thus, it could be concluded that the use of Tabernaemontana divaricata extract in the treatment of carcinogen induced hepatic necrosis. PMID:25136566

  7. Patterns of cellular immunity associated with experimental infection with rDEN2Δ30 (Tonga/74) supports its suitability as a human DENV challenge strain.

    PubMed

    Grifoni, Alba; Angelo, Michael; Sidney, John; Paul, Sinu; Peters, Bjoern; de Silva, Aruna D; Phillips, Elizabeth; Mallal, Simon; Diehl, Sean A; Botten, Jason; Boyson, Jonathan; Kirkpatrick, Beth D; Whitehead, Stephen S; Durbin, Anna P; Sette, Alessandro; Weiskopf, Daniela

    2017-02-01

    A deletion variant of the DENV2 Tonga/74 strain lacking 30 nucleotides from its 3' untranslated region (rDEN2Δ30) has previously been established for use in a controlled DENV human challenge model. To evaluate if this model is appropriate to derive correlates of protection for DENV vaccines based on cellular immunity, we wanted to compare how the cellular immune response to this challenge strain compares to the response induced by natural infection. To achieve this, we predicted HLA class I and class II restricted peptides from rDEN2Δ30 and used them, in an IFN-gamma ELISPOT assay, to interrogate CD8(+) and CD4(+) T cell responses in healthy volunteers infected with rDEN2Δ30. At the level of CD8 responses, vigorous ex vivo responses were detected in approximately 80% of donors. These responses were similar in terms of magnitude and numbers of epitopes recognized to previously reported responses observed in PBMC from donors from DENV hyper-endemic regions. The similarity extended to the immunodominance hierarchy of the DENV nonstructural proteins NS3, NS5, and NS1 being dominant in both donor cohorts. At the CD4 level, responses were less vigorous compared to natural DENV infection, and were more focused on nonstructural proteins. The epitopes recognized following rDEN2Δ30 infection and natural infection were largely overlapping for both CD8 (100%) and CD4 (85%) responses. Finally, rDEN2Δ30 induced stronger CD8 responses compared to other more attenuated DENV isolates.

  8. Accounting for model error in air quality forecasts: an application of 4DEnVar to the assimilation of atmospheric composition using QG-Chem 1.0

    NASA Astrophysics Data System (ADS)

    Emili, Emanuele; Gürol, Selime; Cariolle, Daniel

    2016-11-01

    Model errors play a significant role in air quality forecasts. Accounting for them in the data assimilation (DA) procedures is decisive to obtain improved forecasts. We address this issue using a reduced-order coupled chemistry-meteorology model based on quasi-geostrophic dynamics and a detailed tropospheric chemistry mechanism, which we name QG-Chem. This model has been coupled to the software library for the data assimilation Object Oriented Prediction System (OOPS) and used to assess the potential of the 4DEnVar algorithm for air quality analyses and forecasts. The assets of 4DEnVar include the possibility to deal with multivariate aspects of atmospheric chemistry and to account for model errors of a generic type. A simple diagnostic procedure for detecting model errors is proposed, based on the 4DEnVar analysis and one additional model forecast. A large number of idealized data assimilation experiments are shown for several chemical species of relevance for air quality forecasts (O3, NOx, CO and CO2) with very different atmospheric lifetimes and chemical couplings. Experiments are done both under a perfect model hypothesis and including model error through perturbation of surface chemical emissions. Some key elements of the 4DEnVar algorithm such as the ensemble size and localization are also discussed. A comparison with results of 3D-Var, widely used in operational centers, shows that, for some species, analysis and next-day forecast errors can be halved when model error is taken into account. This result was obtained using a small ensemble size, which remains affordable for most operational centers. We conclude that 4DEnVar has a promising potential for operational air quality models. We finally highlight areas that deserve further research for applying 4DEnVar to large-scale chemistry models, i.e., localization techniques, propagation of analysis covariance between DA cycles and treatment for chemical nonlinearities. QG-Chem can provide a useful tool in this

  9. [Presence of the dinoflagellates Ceratium dens, C. fusus and C. furca (Gonyaulacales: Ceratiaceae) in Golfo de Nicoya, Costa Rica].

    PubMed

    Vargas-Montero, Maribelle; Freer, Enrique

    2004-09-01

    Harmful Algae Blooms (HAB) are a frequent phenomenon in the Gulf of Nicoya, Costa Rica, as in other parts of the world. The morphology and physiology of these microalgae are important because HAB species have adaptive characteristics. The production of high concentrations of paralytic toxins by Ceratium dinoflagellates has only been documented at the experimental level. However, this genus has been associated with the mortality of aquatic organisms, including oyster and shrimp larva, and fish, and with decreased water quality. Recently, fishermen reported massive mortality of encaged fish near Tortuga Island (Gulf of Nicoya). Samples were taken from an algal bloom that had produced an orange coloration and had a strong foul-smelling odor. Ultrastructural details were examined with scanning electron microscopy. The dinoflagellates Ceratium dens, C. furca and C. fusus were found in samples taken at the surface. The cell count revealed four million cells of this genus per liter. The morphological variability of these species is high; therefore electron microscopy is an useful tool in the ultrastructural study of these organisms. This is the first time that three Ceratium species are reported concurrently producing harmful blooms in Costa Rica.

  10. Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice

    PubMed Central

    Feng, T; Dzieran, J; Yuan, X; Dropmann, A; Maass, T; Teufel, A; Marhenke, S; Gaiser, T; Rückert, F; Kleiter, I; Kanzler, S; Ebert, M P; Vogel, A; ten Dijke, P; Dooley, S; Meindl-Beinker, N M

    2017-01-01

    TGF-β signaling in liver cells has variant roles in the dynamics of liver diseases, including hepatocellular carcinoma (HCC). We previously found a correlation of high levels of the important endogenous negative TGF-β signaling regulator SMAD7 with better clinical outcome in HCC patients. However, the underlying tumor-suppressive molecular mechanisms are still unclear. Here, we show that conditional (TTR-Cre) hepatocyte-specific SMAD7 knockout (KO) mice develop more tumors than wild-type and corresponding SMAD7 transgenic mice 9 months after diethylnitrosamine (DEN) challenge, verifying SMAD7 as a tumor suppressor in HCC. In line with our findings in patients, Smad7 levels in both tumor tissue as well as surrounding tissue show a significant inverse correlation with tumor numbers. SMAD7 KO mice presented with increased pSMAD2/3 levels and decreased apoptosis in the tumor tissue. Higher tumor incidence was accompanied by reduced P21 and upregulated c-MYC expression in the tumors. Activation of signal transducer and activator of transcription factor 3 signaling was found in Smad7-deficient mouse tumors and in patients with low tumoral SMAD7 expression as compared with surrounding tissue. Together, our results provide new mechanistic insights into the tumor-suppressive functions of SMAD7 in hepatocarcinogenesis. PMID:28134936

  11. Biological evidence of an oviposition-deterring pheromone inLobesia botrana Den. et Schiff. (Lepidoptera, Tortricidae).

    PubMed

    Gabel, B; Thiéry, D

    1992-03-01

    Females of the European grapevine moth (Lobesia botrana Den. et Schiff.) usually deposit isolated eggs on flowers and berries of the grapevine (Vitis vinifera L.). We have investigated whether an epideictic pheromone could be present on the egg surface to explain this spacing behavior. About 21,000 eggs ofL. botrana were washed in cold methanol, and the biological activity was tested in a two-choice bioassay offering treated and nontreated areas. Different dilutions of the extract were tested in methanol, which was inactive alone. At the dose of four egg equivalents per microliter of extract, the number of eggs laid by theL. botrana females was reduced by as much as 57% on the treated areas compared to nontreated areas. A longer-term suppression of oviposition (at least 24 hr) following an exposure to the extract occurred for two doses (0.6 and 4.0 eggs/μl) of egg extract. Our results strongly suggest the occurrence of an oviposition-deterring pheromone (ODP) on the eggs ofL. botrana. The ecological value of these results is discussed.

  12. 75 FR 12564 - Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-16

    ... Hollywood Animals, Inc... 74 FR 47821; September January 15, 2010 17, 2009. 060472 Hollywood Animals, Inc... 74 FR 47821; September January 15, 2010 17, 2009. 060473 Hollywood Animals, Inc... 74 FR...

  13. "Das Konkrete ist das Abstrakte, an das man sich schließlich gewöhnt hat." (Laurent Schwartz) Über den Ablauf des mathematischen Verstehens

    NASA Astrophysics Data System (ADS)

    Lowsky, Martin

    Die im Titel genannte Aussage findet sich in den Lebenserinnerungen von Laurent Schwartz (1915-2002), einem der fruchtbarsten Mathematiker, Mitglied der Gruppe Bourbaki. Im Original lautet die Aussage: "un objet concret est un objet abstrait auquel on a fini par s'habituer." Schwartz erläutert sie am Beispiel des Integrals über {e^{-1/2{x^2}}} , das den Wert Wurzel aus 2π hat und in dem sich also die Zahlen e und π verknüpfen. Was Schwartz aber vor allem ausdrücken will, ist dies: Das mathematische Verständnisd geht langsam vor sich und es bedarf der Anstrengung. "Es ist eine Frage der Zeit und der Energie", sagt Schwartz, und gerade dies mache es so schwer, die höhere Mathematik unter das Volk zu bringen. Das Lernen und Lehren von Mathematik laufe eben mühevoll und langsam ab.

  14. A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4Δ30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers.

    PubMed

    Pierce, Kristen K; Whitehead, Stephen S; Kirkpatrick, Beth D; Grier, Palmtama L; Jarvis, Adrienne; Kenney, Heather; Carmolli, Marya P; Reynolds, Cynthia; Tibery, Cecilia M; Lovchik, Janece; Janiak, Anna; Luke, Catherine J; Durbin, Anna P; Pletnev, Alexander G

    2017-01-01

    West Nile virus (WNV) is a major cause of mosquito-borne illness in the United States. Human disease ranges from mild febrile illness to severe fatal neurologic infection. Adults aged >60 years are more susceptible to neuroinvasive disease accompanied by a high mortality rate or long-lasting neurologic sequelae. A chimeric live attenuated West Nile virus vaccine, rWN/DEN4Δ30, was shown to be safe and immunogenic in healthy adults aged 18-50 years. This study evaluated rWN/DEN4Δ30 in flavivirus-naive adults aged 50-65 years and found it to be safe and immunogenic. Outbreaks of WNV infection tend to be unpredictable, and a safe and effective vaccine will be an important public health tool.

  15. Studying at the Universities of the Armed Forces: Comparative Results from the 1999 Student Questionnaire (Studieren an den UniBw: Vergleichende Ergebnisse aus der Studentenbefragung 1999)

    DTIC Science & Technology

    2002-12-01

    distanziert kollegial UniBw Miinchen: Auf den ersten Blick scheint das allgemeine Kommunikationsgeschehen in M • nchen im Prinzip dem an der Hamburger UniBw...Hochschulforschung m )chten wir an dieser Stelle danken fMr das Oberlassen des Frageinstrumen- tariums, das dem ZHQ zur Nutzung fu-r die eigene...gerweise war schon im Grandungskonzept der UniBw diesem Moment einer m ~glichst nahen, en- gen und transparenten Kommunikation besondere Beachtung

  16. DensToolKit: A comprehensive open-source package for analyzing the electron density and its derivative scalar and vector fields

    NASA Astrophysics Data System (ADS)

    Solano-Altamirano, J. M.; Hernández-Pérez, Julio M.

    2015-11-01

    DensToolKit is a suite of cross-platform, optionally parallelized, programs for analyzing the molecular electron density (ρ) and several fields derived from it. Scalar and vector fields, such as the gradient of the electron density (∇ρ), electron localization function (ELF) and its gradient, localized orbital locator (LOL), region of slow electrons (RoSE), reduced density gradient, localized electrons detector (LED), information entropy, molecular electrostatic potential, kinetic energy densities K and G, among others, can be evaluated on zero, one, two, and three dimensional grids. The suite includes a program for searching critical points and bond paths of the electron density, under the framework of Quantum Theory of Atoms in Molecules. DensToolKit also evaluates the momentum space electron density on spatial grids, and the reduced density matrix of order one along lines joining two arbitrary atoms of a molecule. The source code is distributed under the GNU-GPLv3 license, and we release the code with the intent of establishing an open-source collaborative project. The style of DensToolKit's code follows some of the guidelines of an object-oriented program. This allows us to supply the user with a simple manner for easily implement new scalar or vector fields, provided they are derived from any of the fields already implemented in the code. In this paper, we present some of the most salient features of the programs contained in the suite, some examples of how to run them, and the mathematical definitions of the implemented fields along with hints of how we optimized their evaluation. We benchmarked our suite against both a freely-available program and a commercial package. Speed-ups of ˜2×, and up to 12× were obtained using a non-parallel compilation of DensToolKit for the evaluation of fields. DensToolKit takes similar times for finding critical points, compared to a commercial package. Finally, we present some perspectives for the future development and

  17. Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes.

    PubMed

    Hytönen, Marjo K; Arumilli, Meharji; Lappalainen, Anu K; Owczarek-Lipska, Marta; Jagannathan, Vidhya; Hundi, Sruthi; Salmela, Elina; Venta, Patrick; Sarkiala, Eva; Jokinen, Tarja; Gorgas, Daniela; Kere, Juha; Nieminen, Pekka; Drögemüller, Cord; Lohi, Hannes

    2016-05-01

    One to two percent of all children are born with a developmental disorder requiring pediatric hospital admissions. For many such syndromes, the molecular pathogenesis remains poorly characterized. Parallel developmental disorders in other species could provide complementary models for human rare diseases by uncovering new candidate genes, improving the understanding of the molecular mechanisms and opening possibilities for therapeutic trials. We performed various experiments, e.g. combined genome-wide association and next generation sequencing, to investigate the clinico-pathological features and genetic causes of three developmental syndromes in dogs, including craniomandibular osteopathy (CMO), a previously undescribed skeletal syndrome, and dental hypomineralization, for which we identified pathogenic variants in the canine SLC37A2 (truncating splicing enhancer variant), SCARF2 (truncating 2-bp deletion) and FAM20C (missense variant) genes, respectively. CMO is a clinical equivalent to an infantile cortical hyperostosis (Caffey disease), for which SLC37A2 is a new candidate gene. SLC37A2 is a poorly characterized member of a glucose-phosphate transporter family without previous disease associations. It is expressed in many tissues, including cells of the macrophage lineage, e.g. osteoclasts, and suggests a disease mechanism, in which an impaired glucose homeostasis in osteoclasts compromises their function in the developing bone, leading to hyperostosis. Mutations in SCARF2 and FAM20C have been associated with the human van den Ende-Gupta and Raine syndromes that include numerous features similar to the affected dogs. Given the growing interest in the molecular characterization and treatment of human rare diseases, our study presents three novel physiologically relevant models for further research and therapy approaches, while providing the molecular identity for the canine conditions.

  18. Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes

    PubMed Central

    Hytönen, Marjo K.; Arumilli, Meharji; Lappalainen, Anu K.; Owczarek-Lipska, Marta; Jagannathan, Vidhya; Hundi, Sruthi; Salmela, Elina; Venta, Patrick; Sarkiala, Eva; Jokinen, Tarja; Gorgas, Daniela; Kere, Juha; Nieminen, Pekka

    2016-01-01

    One to two percent of all children are born with a developmental disorder requiring pediatric hospital admissions. For many such syndromes, the molecular pathogenesis remains poorly characterized. Parallel developmental disorders in other species could provide complementary models for human rare diseases by uncovering new candidate genes, improving the understanding of the molecular mechanisms and opening possibilities for therapeutic trials. We performed various experiments, e.g. combined genome-wide association and next generation sequencing, to investigate the clinico-pathological features and genetic causes of three developmental syndromes in dogs, including craniomandibular osteopathy (CMO), a previously undescribed skeletal syndrome, and dental hypomineralization, for which we identified pathogenic variants in the canine SLC37A2 (truncating splicing enhancer variant), SCARF2 (truncating 2-bp deletion) and FAM20C (missense variant) genes, respectively. CMO is a clinical equivalent to an infantile cortical hyperostosis (Caffey disease), for which SLC37A2 is a new candidate gene. SLC37A2 is a poorly characterized member of a glucose-phosphate transporter family without previous disease associations. It is expressed in many tissues, including cells of the macrophage lineage, e.g. osteoclasts, and suggests a disease mechanism, in which an impaired glucose homeostasis in osteoclasts compromises their function in the developing bone, leading to hyperostosis. Mutations in SCARF2 and FAM20C have been associated with the human van den Ende-Gupta and Raine syndromes that include numerous features similar to the affected dogs. Given the growing interest in the molecular characterization and treatment of human rare diseases, our study presents three novel physiologically relevant models for further research and therapy approaches, while providing the molecular identity for the canine conditions. PMID:27187611

  19. Paleoenvironmental and Human Behavioral Implications of the Boegoeberg 1 Late Pleistocene Hyena Den, Northern Cape Province, South Africa

    NASA Astrophysics Data System (ADS)

    Klein, Richard G.; Cruz-Uribe, Kathryn; Halkett, David; Hart, Tim; Parkington, John E.

    1999-11-01

    Boegoeberg 1 (BOG1) is located on the Atlantic coast of South Africa, 850 km north of Cape Town. The site is a shallow rock shelter in the side of a sand-choked gully that was emptied by diamond miners. Abundant coprolites, chewed bones, and partially digested bones implicate hyenas as the bone accumulators. The location of the site, quantity of bones, and composition of the fauna imply it was a brown hyena nursery den. The abundance of Cape fur seal bones shows that the hyenas had ready access to the coast. Radiocarbon dates place the site before 37,000 14C yr ago, while the large average size of the black-backed jackals and the presence of extralimital ungulates imply cool, moist conditions, probably during the early part of the last glaciation (isotope stage 4 or stage 3 before 37,000 14C yr ago) or perhaps during one of the cooler phases (isotope substages 5d or 5b) within the last interglaciation. Comparisons of the BOG1 seal bones to those from regional Middle Stone Age (MSA) and Later Stone Age (LSA) archeological sites suggest (1) that hyena and human seal accumulations can be distinguished by a tendency for vertebrae to be much more common in a hyena accumulation and (2) that hyena and LSA accumulations can be distinguished by a tendency for hyena-accumulated seals to represent a much wider range of individual seal ages. Differences in the way hyenas and people dismember, transport, and consume seal carcasses probably explain the contrast in skeletal part representation, while differences in season of occupation explain the contrast in seal age representation. Like modern brown hyenas, the BOG1 hyenas probably occupied the coast year-round, while the LSA people focused their coastal visits on the August-October interval when nine-to-eleven-month-old seals were abundant. The MSA sample from Klasies River Mouth Cave 1 resembles BOG1 in seal age composition, suggesting that unlike LSA people, MSA people obtained seals more or less throughout the year.

  20. Green-synthesized silver nanoparticles as a novel control tool against dengue virus (DEN-2) and its primary vector Aedes aegypti.

    PubMed

    Sujitha, Vasu; Murugan, Kadarkarai; Paulpandi, Manickam; Panneerselvam, Chellasamy; Suresh, Udaiyan; Roni, Mathath; Nicoletti, Marcello; Higuchi, Akon; Madhiyazhagan, Pari; Subramaniam, Jayapal; Dinesh, Devakumar; Vadivalagan, Chithravel; Chandramohan, Balamurugan; Alarfaj, Abdullah A; Munusamy, Murugan A; Barnard, Donald R; Benelli, Giovanni

    2015-09-01

    Dengue is an arthropod-borne viral infection mainly vectored through the bite of Aedes mosquitoes. Recently, its transmission has strongly increased in urban and semi-urban areas of tropical and sub-tropical regions worldwide, becoming a major international public health concern. There is no specific treatment for dengue. Its prevention and control solely depends on effective vector control measures. In this study, we proposed the green-synthesis of silver nanoparticles (AgNP) as a novel and effective tool against the dengue serotype DEN-2 and its major vector Aedes aegypti. AgNP were synthesized using the Moringa oleifera seed extract as reducing and stabilizing agent. AgNP were characterized using a variety of biophysical methods including UV-vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and sorted for size categories. AgNP showed in vitro antiviral activity against DEN-2 infecting vero cells. Viral titer was 7 log10 TCID50/ml in control (AgNP-free), while it dropped to 3.2 log10 TCID50/ml after a single treatment with 20 μl/ml of AgNP. After 6 h, DEN-2 yield was 5.8 log10 PFU/ml in the control, while it was 1.4 log10 PFU/ml post-treatment with AgNP (20 μl/ml). AgNP were highly effective against the dengue vector A. aegypti, with LC50 values ranging from 10.24 ppm (I instar larvae) to 21.17 ppm (pupae). Overall, this research highlighted the concrete potential of green-synthesized AgNP in the fight against dengue and its primary vector A. aegypti. Further research on structure-activity relationships of AgNP against other dengue serotypes is urgently required.

  1. 77 FR 49024 - Sai Wentum, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ..., 71 FR 39130, 39131 (2006); Dominick A. Ricci, 58 FR 51104, 51105 (1993); Bobby Watts, 53 FR 11919... practitioner has lost his state authority to dispense controlled substances. James L. Hooper, 76 FR...

  2. Cross Sections: No. 1 Hold section at Fr 24 Looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Cross Sections: No. 1 Hold section at Fr 24 Looking Fwd, No 1 Hold Section at Fr 28 Looking Aft, No 2 Hold Section at Fr 48 Looking Aft, No 3 Hold Section at Fr 70 Looking Aft, No 4 Hold Section at Fr 90 Looking Aft - General John Pope, Suisun Bay Reserve Fleet, Benicia, Solano County, CA

  3. 78 FR 75346 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-11

    ... respondents: FR Y-11 (quarterly): 409; FR Y-11 (annual): 203; FR Y-11S: 255. General description of report... (quarterly): 551; FR 2314 (annual): 220; FR 2314S: 308. General description of report: This information... comment period, the proposed information collections, along with an analysis of comments...

  4. 78 FR 27984 - Modification of the National Customs Automation Program Test (NCAP) Regarding Reconciliation for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-13

    ... announced and explained the test in a general notice document published in the Federal Register (63 FR 6257... Register notices: 63 FR 44303, published on August 18, 1998; 64 FR 39187, published on July 21, 1999; 64 FR 73121, published on December 29, 1999; 66 FR 14619, published on March 13, 2001; 67 FR 61200,...

  5. 77 FR 71592 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ... Investments Held for an Extended Period. Agency form number: FR Y-12, FR Y12A, respectively. OMB control number: 7100-0300. Frequency: FR Y-12: quarterly or semi-annually, FR Y-12A: annually. Reporters: Bank...). Estimated annual reporting hours: FR Y-12: 2,112 hours, FR Y-12A: 126 hours. Estimated average hours...

  6. 75 FR 47540 - Extension of the Award Period for Certain Minority Business Enterprise Centers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... Beach MSA. Mississippi MBEC Arkansas Regional State of Mississippi.... 71 FR 42351, as amended by 71 FR.../ 71 FR 42351, as amended by 74 FR 58246. Arlington MSA. El Paso MBEC El Paso Hispanic Chamber El Paso MSA 72 FR 71621, as amended by 74 FR 58246. of Commerce. New Mexico MBEC NEDA Business State of...

  7. 78 FR 76789 - Additional Connect America Fund Phase II Issues

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ... Support Disbursements. In the USF/ICC Transformation Order, 76 FR 73830, November 29, 2011, the Commission... Transformation Order and FNPRM, 76 FR 73830, November 29, 2011 and 76 FR 78384, December 16, 2011, included...

  8. 78 FR 79412 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... Maintaining Records About Individuals,'' dated February 8, 1996 (February 20, 1996, 61 FR 6427). Dated... 13, 2007, 72 FR 32630) Changes: * * * * * Categories of individuals covered by the system:...

  9. Morphological and molecular investigations of a microsporidium infecting the European grape vine moth, Lobesia botrana Den. et Schiff., and its taxonomic determination as Cystosporogenes legeri nov. comb.

    PubMed

    Kleespies, Regina G; Vossbrinck, Charles R; Lange, Martin; Jehle, Johannes A

    2003-07-01

    We have isolated a microsporidium from a laboratory stock of the European grape vine moth, Lobesia botrana Den. et Schiff. (Lepidoptera, Tortricidae). Screening of this stock showed an infection rate of more than 90%, whereas field collected larvae from three different locations in Rhineland-Palatinate (Germany) did not demonstrate any signs of infection. Light and electron microscopic investigations of infected insects showed that gross pathology, morphology, and ultrastructure of the microsporidium are similar to those described earlier for Pleistophora legeri. Comparative phylogenetic analysis of the small subunit rDNA using maximum likelihood, maximum parsimony, and neighbour joining distance methods showed that our isolate was closely related to Cystosporogenes operophterae. Based on our morphological and molecular investigations we propose to rename this species Cystosporogenes legeri nov. comb.

  10. Transoral vertebral augmentation with polymethylmethacrylate in the treatment of a patient with a dens fracture nonunion and subarticular vertebral body fracture of C2.

    PubMed

    Beall, Douglas P; Stanfield, Matthew; Martin, Hal D; Stapp, Annette M

    2007-05-01

    The injection of polymethylmethacrylate (PMMA) is a minimally invasive, image-guided procedure used to treat vertebral fractures due to osteoporosis, metastatic lesions, multiple myeloma, and benign but destabilizing bone tumors. The injection of PMMA into the C2 vertebral body using the transoral technique has been reported in three separate patients for treatment of benign tumors (a vertebral hemangioma and an aneurysmal bone cyst) and for multiple myeloma in the third patient. Although the injection of PMMA into the vertebral body is most commonly performed to treat benign vertebral compression fractures, a transoral C2 approach has not been reported in the English literature as a treatment for a benign fracture of C2. We report the treatment of a fracture and nonunion of the base of the dens and a subarticular fracture of the vertebral body of C2 using a bilateral transoral approach.

  11. Factors Affecting Date of Implantation, Parturition, and Den Entry Estimated from Activity and Body Temperature in Free-Ranging Brown Bears

    PubMed Central

    Friebe, Andrea; Evans, Alina L.; Arnemo, Jon M.; Blanc, Stéphane; Brunberg, Sven; Fleissner, Günther; Swenson, Jon E.; Zedrosser, Andreas

    2014-01-01

    Knowledge of factors influencing the timing of reproduction is important for animal conservation and management. Brown bears (Ursus arctos) are able to vary the birth date of their cubs in response to their fat stores, but little information is available about the timing of implantation and parturition in free-ranging brown bears. Body temperature and activity of pregnant brown bears is higher during the gestation period than during the rest of hibernation and drops at parturition. We compared mean daily body temperature and activity levels of pregnant and nonpregnant females during preimplantation, gestation, and lactation. Additionally we tested whether age, litter size, primiparity, environmental conditions, and the start of hibernation influence the timing of parturition. The mean date of implantation was 1 December (SD = 12), the mean date of parturition was 26 January (SD = 12), and the mean duration of the gestation period was 56 days (SD = 2). The body temperature of pregnant females was higher during the gestation and lactation periods than that of nonpregnant bears. The body temperature of pregnant females decreased during the gestation period. Activity recordings were also used to determine the date of parturition. The parturition dates calculated with activity and body temperature data did not differ significantly and were the same in 50% of the females. Older females started hibernation earlier. The start of hibernation was earlier during years with favorable environmental conditions. Dates of parturition were later during years with good environmental conditions which was unexpected. We suggest that free-ranging pregnant brown bears in areas with high levels of human activities at the beginning of the denning period, as in our study area, might prioritize investing energy in early denning than in early parturition during years with favorable environmental conditions, as a strategy to prevent disturbances caused by human. PMID:24988486

  12. Factors affecting date of implantation, parturition, and den entry estimated from activity and body temperature in free-ranging brown bears.

    PubMed

    Friebe, Andrea; Evans, Alina L; Arnemo, Jon M; Blanc, Stéphane; Brunberg, Sven; Fleissner, Günther; Swenson, Jon E; Zedrosser, Andreas

    2014-01-01

    Knowledge of factors influencing the timing of reproduction is important for animal conservation and management. Brown bears (Ursus arctos) are able to vary the birth date of their cubs in response to their fat stores, but little information is available about the timing of implantation and parturition in free-ranging brown bears. Body temperature and activity of pregnant brown bears is higher during the gestation period than during the rest of hibernation and drops at parturition. We compared mean daily body temperature and activity levels of pregnant and nonpregnant females during preimplantation, gestation, and lactation. Additionally we tested whether age, litter size, primiparity, environmental conditions, and the start of hibernation influence the timing of parturition. The mean date of implantation was 1 December (SD = 12), the mean date of parturition was 26 January (SD = 12), and the mean duration of the gestation period was 56 days (SD = 2). The body temperature of pregnant females was higher during the gestation and lactation periods than that of nonpregnant bears. The body temperature of pregnant females decreased during the gestation period. Activity recordings were also used to determine the date of parturition. The parturition dates calculated with activity and body temperature data did not differ significantly and were the same in 50% of the females. Older females started hibernation earlier. The start of hibernation was earlier during years with favorable environmental conditions. Dates of parturition were later during years with good environmental conditions which was unexpected. We suggest that free-ranging pregnant brown bears in areas with high levels of human activities at the beginning of the denning period, as in our study area, might prioritize investing energy in early denning than in early parturition during years with favorable environmental conditions, as a strategy to prevent disturbances caused by human.

  13. 78 FR 16894 - In the Matter of Luminant Generation Company LLC, Comanche Peak Nuclear Power Plant, Units 1 and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... notice that was published in the Federal Register (FR) on March 5, 2013 (78 FR 14361), regarding the....Bladey@nrc.gov . Correction In the FR of March 5, 2013, in FR Doc. 2013-05021, on page 14362,...

  14. 76 FR 68127 - Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ...] [FR Doc No: 2011-28540] ARCHITECTURAL AND TRANSPORTATION BARRIERS COMPLIANCE BOARD Meetings AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice of meetings. SUMMARY: The Architectural and Transportation Barriers Compliance Board (Access Board) plans to hold its regular...

  15. 75 FR 2560 - Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    .... 217648 U.S. Fish and Wildlife 74 FR 37240, July 28, December 8, 2009 Service. 2009. 222610 Atlanta-Fulton.... Pylman....... 74 FR 58977; November December 23, 2009 16, 2009. 231522 Robert B. Spencer...... 74...

  16. 75 FR 21963

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... Title Identifier Number Number 432 Rule 15c2-2: Confirmation of Transactions in Open-End Management... Education Savings 433 Rule 15c2-3: Point-of-Sale Disclosure of Purchases in Open-End Management Investment... NPRM 07/17/09 74 FR 35076 NPRM Comment Period End 09/15/09 Final Action 12/23/09 74 FR 68334 ]...

  17. Discovery of a new species of hermit crab of the genus Pylopaguropsis Alcock, 1905 from the Caribbean: "den commensal" or "cleaner"? (Crustacea, Anomura, Paguridae).

    PubMed

    Lemaitre, Rafael

    2017-01-01

    A new secretive, yet brightly colored hermit crab species of the family Paguridae, Pylopaguropsis mollymulleraesp. n., is fully described based on specimens from the reefs of Bonaire, Lesser Antilles, southern Caribbean Sea. Populations of this new species were discovered and photographed in the Bonaire National Marine Park under a large coral ledge, at a depth of 13.7 m, living in crevices known by scuba divers to serve as den to a pair of "flaming reef lobsters" Enoplometopus antillensis, or a "broad banded moray" Channomuraena vittata. This new species is only the second species of Pylopaguropsis Alcock, 1905 known from the western Atlantic, the 20(th) named worldwide, and belongs in the teevana group of species of the genus. It is remarkably similar, and herein considered geminate, to the tropical eastern Pacific congener, Pylopaguropsis teevana (Boone, 1932), the two being characterized and uniquely different from all other species of the genus, by the striking and deeply excavated, scoop-like ventral surface of the chela of the right cheliped. Minor differences separate this new species from Pylopaguropsis teevana in the relative length of the antennal acicles (exceeding the corneas versus not exceeding the corneas in Pylopaguropsis teevana); dorsal armature of the right chela (smooth or with scattered minute tubercles versus with numerous small tubercles in Pylopaguropsis teevana); surface shape of the lateral face of the dactyl of right pereopod 3 (evenly convex versus flattened in Pylopaguropsis teevana); and coloration (red bright red stripes versus brown stripes in Pylopaguropsis teevana). The highly visible color pattern of bright red stripes on white background typical of decapods known to have cleaning symbioses with fish, dense setation on the flagella of the antennae, and preference for a crevicular habitat, combined with brief in situ nocturnal observations, suggests the possibility that Pylopaguropsis mollymullerae sp. n. engages in "cleaner

  18. Discovery of a new species of hermit crab of the genus Pylopaguropsis Alcock, 1905 from the Caribbean: “den commensal” or “cleaner”? (Crustacea, Anomura, Paguridae)

    PubMed Central

    Lemaitre, Rafael

    2017-01-01

    Abstract A new secretive, yet brightly colored hermit crab species of the family Paguridae, Pylopaguropsis mollymullerae sp. n., is fully described based on specimens from the reefs of Bonaire, Lesser Antilles, southern Caribbean Sea. Populations of this new species were discovered and photographed in the Bonaire National Marine Park under a large coral ledge, at a depth of 13.7 m, living in crevices known by scuba divers to serve as den to a pair of “flaming reef lobsters” Enoplometopus antillensis, or a “broad banded moray” Channomuraena vittata. This new species is only the second species of Pylopaguropsis Alcock, 1905 known from the western Atlantic, the 20th named worldwide, and belongs in the teevana group of species of the genus. It is remarkably similar, and herein considered geminate, to the tropical eastern Pacific congener, Pylopaguropsis teevana (Boone, 1932), the two being characterized and uniquely different from all other species of the genus, by the striking and deeply excavated, scoop-like ventral surface of the chela of the right cheliped. Minor differences separate this new species from Pylopaguropsis teevana in the relative length of the antennal acicles (exceeding the corneas versus not exceeding the corneas in Pylopaguropsis teevana); dorsal armature of the right chela (smooth or with scattered minute tubercles versus with numerous small tubercles in Pylopaguropsis teevana); surface shape of the lateral face of the dactyl of right pereopod 3 (evenly convex versus flattened in Pylopaguropsis teevana); and coloration (red bright red stripes versus brown stripes in Pylopaguropsis teevana). The highly visible color pattern of bright red stripes on white background typical of decapods known to have cleaning symbioses with fish, dense setation on the flagella of the antennae, and preference for a crevicular habitat, combined with brief in situ nocturnal observations, suggests the possibility that Pylopaguropsis mollymullerae sp. n. engages

  19. 77 FR 58556 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... by FR Y-12 or FR Y-12A, by any of the following methods: Agency Web Site: http://www.federalreserve... viewed electronically or in paper form in Room MP- 500 of the Board's Martin Building (20th and C Streets... Investments Held for an Extended Period. Agency form number: FR Y-12, FR Y12A, respectively. OMB...

  20. 78 FR 54481 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    .......... 78 FR 37563; June 21, 2013...... August 8, 2013. 08815B William Tones 78 FR 37562; June 21, 2013...... August 8, 2013. 09161B John Alexander......... 78 FR 40762; July 8, 2013....... August 9, 2013. 99464A Donald Lepp 78 FR 19732; April 2, 2013...... June 7, 2013. Marine Mammals Receipt of application...

  1. 76 FR 44353 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... Permit No. Applicant Federal date Register notice 28080A St. John Fisher 76 FR 12990; June 16, 2011. College. March 9, 2011. 38879A Scott Ackleson.. 76 FR 27660; June 17, 2011. May 12, 2011. 44242A Larry Hildreth.. 76 FR 32223; July 05, 2011. June 3, 2011. 43070A Keith Jefferson. 76 FR 32223; July 12,...

  2. 76 FR 18536 - Agency Information Collection Activities Under OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ... soliciting comments on this collection of information was published on January 11, 2011. 76 FR 1603. \\2... FR 1603, 1604. \\5\\ See CFTC NPRM: End-User Exception to Mandatory Clearing of Swaps, 75 FR 80747... FR 1603, 1604. The estimated average hourly burden was estimated at .5 hours. Burden Statement:...

  3. 78 FR 48712 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... 78 FR 9725; February 11, June 14, 2013. the University of 2013. Illinois. 675484 Birmingham Zoo, Inc..... 78 FR 16292; March 14, May 1, 2013. 2013. 036218 Brevard Zoo 78 FR 1771; March 22, May 1, 2013. 2013. 682781 Chicago Zoological 78 FR 1771; March 22, May 1, 2013. Society. 2013. 808265 Gary Johnson 78...

  4. 77 FR 3514 - Protection Against Turbine Missiles

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... [Federal Register Volume 77, Number 15 (Tuesday, January 24, 2012)] [Notices] [Page 3514] [FR Doc..., 2009 (74 FR 56672) for a 60 day public comment period. DG-1217 was reissued for public comment on May 6, 2011 (76 FR 26320). The public comment period closed on June 3, 2011. The staff's responses to...

  5. 76 FR 73496 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ...., Monday through Friday, except Federal holidays. The AD docket contains the NPRM (76 FR 42602, July 19... the fasteners installation in the junction keel beam fitting at FR 40, in accordance with Airbus... installation in the junction keel beam fitting at FR 40, in accordance with Airbus Service Bulletin...

  6. 78 FR 79292 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... corresponds to FAA AD 2007-14-01, Amendment 39-15123, (72 FR 38006, July 12, 2007)] to require compliance with... 2007-14-01, Amendment 39-15123, (72 FR 38006, July 12, 2007)] to require compliance with FAL specified... also adds new airplanes to the applicability of this AD. AD 2011-24-09 (76 FR 73486, November 29,...

  7. Unmasking of a Recessive SCARF2 Mutation by a 22q11.12 de novo Deletion in a Patient with Van den Ende-Gupta Syndrome

    PubMed Central

    Bedeschi, M.F.; Colombo, L.; Mari, F.; Hofmann, K.; Rauch, A.; Gentilin, B.; Renieri, A.; Clerici, D.

    2011-01-01

    Van den Ende-Gupta syndrome (VDEGS) is a congenital condition characterized by craniofacial and skeletal manifestations, specifically blepharophimosis, malar and maxillary hypoplasia, distinctive nose, arachnocamptodactyly, and long slender bones of the hands and feet. To date, only 24 patients have been described. It is generally thought that the syndrome is transmitted by an autosomal recessive mode of inheritance, although evidence for genetic heterogeneity has recently been presented. We report on a girl followed from birth up to 3 years of life with a set of peculiar minor anomalies, arachnocamptodactyly of hands and feet, characteristic of VDEGS in association with a 22q11.12 deletion. Recently, the VDEGS gene was mapped to the DiGeorge syndrome region on 22q11.2, and homozygous mutations in the SCARF2 gene were identified. We now report the first patient with VDEGS due to compound heterozygosity for the common 22q11.2 microdeletion and a hemizygous SCARF2 splice site mutation. PMID:22140376

  8. Effekt einer ad libitum verzehrten fettreduzierten Kost, reich an Obst, Gemüse und Milchprodukten auf den Blutdruck bei Borderline-Hypertonikern

    NASA Astrophysics Data System (ADS)

    Möseneder, Jutta M.

    2002-01-01

    In der randomisierten, multizentrischen DASH-Studie (Dietary Approaches to Stop Hy-pertension), die unter kontrollierten Bedingungen stattfand, führte eine fettreduzierte Mischkost, reich an Obst, Gemüse und Milchprodukten, bei Borderline-Hypertonikern zu einer signifikanten Blutdrucksenkung. Während der Studienphase wurden Körpermasse, Natrium-Aufnahme sowie Alkoholzufuhr aufgrund der bekannten Einflussnahme auf den Blutdruck konstant gehalten. In der eigenen Pilot-Studie sollte untersucht werden, ob das Ergebnis der DASH-Studie (i) mit deutschen Hypertonikern und (ii) unter habituellen Ernährungs- und Lebensbedingungen mit regelmäßig durchgeführter Ernährungsberatung und ad libitum Verzehr anstelle des streng kontrollierten Studienansatzes bestätigt werden kann. Eine Konstanz der Körpermasse, der Natrium-Urinausscheidung (unter diesem Studienansatz valider als die Aufnahme) und des Alkoholkonsums wurde vorausgesetzt. Die Studienpopulation setzte sich aus 53 übergewichtigen Probanden mit einer nicht medikamentös therapierten Borderline-Hypertonie und ohne Stoffwechselerkrankungen zusammen. Die Studienteilnehmer wurden randomisiert entweder der Idealgruppe mit einer fettarmen Kost reich an Milchprodukten, Obst und Gemüse (ähnlich der DASH-Idealgruppe) oder der Kontrollgruppe mit habitueller Ernährungsweise zugeteilt. Über einen Zeitraum von fünf Wochen wurde den Probanden etwa 50% ihres täglichen Lebensmittelbedarfes entsprechend ihrer Gruppenzugehörigkeit kostenfrei zur Verfügung gestellt. Gelegenheitsblutdruckmessungen und 24h-Blutdruckmessungen, Ernährungs- und Aktivitätsprotokolle, Blut- und Urinproben sowie anthropometrische Messungen wurden vor, während und fünf Wochen nach der Interventionsphase durchgeführt. Die Ergebnisse zeigen, dass in der Idealgruppe keine signifikante Blutdrucksenkung beobachtet werden konnte. Dies lässt sich durch die Tatsache erklären, dass die Lebens-mittel- und Nährstoffaufnahme der deutschen

  9. [Immunohistochemical Analysis of Krebs von den Lungen-6 (KL-6) Expression in Lung Tissue in Primary Lung Cancer Patients with High Serum KL-6 Levels].

    PubMed

    Yatsuyanagi, Eiji; Sato, Kazuhiro; Sato, Keisuke

    2015-09-01

    We investigated sialylated carbohydrate antigen( Krebs von den Lungen-6:KL-6) expression in lung tissue and correlation between the expression and serum KL-6 level in the patients with primary lung cancer. Thirty-four primary lung cancer patients with high serum KL-6 levels( >500 U/ml) were evaluated. A coexistence of interstitial pneumonia (IP) was histopathologically evaluated and an immunohistochemical staining using a mouse anti-human KL-6 antibody (mKL-6) was performed. A multiple regression analysis was also caluculated using a serum KL-6 level as a target variable and the histopathological and immunohistochemical factors (KL-6 expression in cancer tissue and IP tissue, coexistence of IP, tumor size, pathological staging) as descriptive variables. Twenty-two patients (64.7%) were histopathologically concomitant with IP. Cancer tissues were positively stained by mKL-6 in 32 patients (94.1%). Among them, 20 patients were concomitant with IP and all of their cancer tissues were more strongly stained by mKL-6 than IP tissues. Although considerable high rate of lung cancer patients might express the KL-6 in the cancer tissue, we could not reveal the relationship between the expression and serum KL-6 level by a multiple regression analysis. For revealing the mechanism of elevating serum KL-6 level in the patients with lung cancer, more detailed and powerful study is thought to be needed.

  10. Anti-influenza A virus activity of a new dihydrochalcone diglycoside isolated from the Egyptian seagrass Thalassodendron ciliatum (Forsk.) den Hartog.

    PubMed

    Mohammed, Magdy M D; Hamdy, Abdel-Hamid A; El-Fiky, Nabaweye M; Mettwally, Walaa S A; El-Beih, Ahmed A; Kobayashi, Nobuyuki

    2014-01-01

    One new dihydrochalcone diglycoside has been isolated from the EtOAc fraction of the Egyptian seagrass Thalassodendrin ciliatum (Forsk.) den Hartog, and was identified as 6'-O-rhamnosyl-(1‴ → 6″)-glucopyranosyl asebogenin for which a trivial name Thalassodendrone was established. Furthermore, five known phenolics were isolated and identified as asebotin, quercetin 3,7-diglucoside, protocatechuic acid, ferulic acid and p-hydroxybenzoic acid. The structures of all the isolated compounds were established based on 1D and 2D NMR spectroscopy and high-resolution-mass spectrometer. High-resolution electrospray ionization mass spectra (HR-ESI-MS) were obtained using a JEOL JMS-T100TD spectrometer (JEOL Ltd., Tokyo, Japan). The anti-influenza A virus activity of the isolated new compound and asebotin was evaluated, and the obtained results revealed that the inhibition dose concentration of asebotin was more than that of Thalassodendrone with IC50 = 2.00 and 1.96 μg/mL, respectively, and with cytotoxic concentration (CC50) of 3.36 and 3.14 μg/mL, respectively.

  11. Differential predation by age and sex classes in blue wildebeest in Serengeti: study of a modern carnivore den in Olduvai Gorge (Tanzania).

    PubMed

    Arriaza, Mari Carmen; Domínguez-Rodrigo, Manuel; Martínez-Maza, Cayetana; Mabulla, Audax; Baquedano, Enrique

    2015-01-01

    Age and sex selection of prey is an aspect of predator ecology which has been extensively studied in both temperate and African ecosystems. This dimension, along with fecundity, survival rates of prey and mortality factors other than predation are important in laying down the population dynamics of prey and have important implications in the management of species. A carnivore den located in the short-grassland ecological unit of the Serengeti was studied. Sex- and age- class (using five age categories) of the wildebeest remains recovered were analyzed through horn morphology, biometrics of the bones and tooth wear patterns. We compared our results with previous studies from lion and hyaena kills through multivariate analyses. Seasonality of the accumulation was analyzed through tooth histology. PCA and CVA results show that age class selection by predators depends on season, habitat-type, and growth rate of the wildebeest population. Female-biased predation was found to contradict classical hypotheses based on territorial male behaviour. The lion and spotted hyaena showed strong selection on age classes, contrary to previous studies. Migratory wildebeest sex ratio is regulated through differential predation by seasons and female deaths in the wet season are a trade-off for population stability. These data are crucial for an effective management of the species and the new method created may be useful for different carnivore species and their prey.

  12. Differential Predation by Age and Sex Classes in Blue Wildebeest in Serengeti: Study of a Modern Carnivore Den in Olduvai Gorge (Tanzania)

    PubMed Central

    Arriaza, Mari Carmen; Domínguez-Rodrigo, Manuel; Martínez-Maza, Cayetana; Mabulla, Audax; Baquedano, Enrique

    2015-01-01

    Age and sex selection of prey is an aspect of predator ecology which has been extensively studied in both temperate and African ecosystems. This dimension, along with fecundity, survival rates of prey and mortality factors other than predation are important in laying down the population dynamics of prey and have important implications in the management of species. A carnivore den located in the short-grassland ecological unit of the Serengeti was studied. Sex- and age- class (using five age categories) of the wildebeest remains recovered were analyzed through horn morphology, biometrics of the bones and tooth wear patterns. We compared our results with previous studies from lion and hyaena kills through multivariate analyses. Seasonality of the accumulation was analyzed through tooth histology. PCA and CVA results show that age class selection by predators depends on season, habitat-type, and growth rate of the wildebeest population. Female-biased predation was found to contradict classical hypotheses based on territorial male behaviour. The lion and spotted hyaena showed strong selection on age classes, contrary to previous studies. Migratory wildebeest sex ratio is regulated through differential predation by seasons and female deaths in the wet season are a trade-off for population stability. These data are crucial for an effective management of the species and the new method created may be useful for different carnivore species and their prey. PMID:26017363

  13. 77 FR 24409 - Medicare and Medicaid Programs: Hospital Outpatient Prospective Payment; Ambulatory Surgical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    ... INFORMATION CONTACT: Erick Chuang, (410) 786-1816. SUPPLEMENTARY INFORMATION: I. Regulatory Overview In FR Doc. 2011-26812 of November 30, 2011 (76 FR 74122) and FR Doc. 2011-33751 of January 4, 2012 (77 FR 217... for payment in the claims year but did not meet the Medicare requirements for payment (76 FR...

  14. 75 FR 52376 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... [Federal Register Volume 75, Number 164 (Wednesday, August 25, 2010)] [Notices] [Pages 52376-52377] [FR Doc No: 2010-21069] OFFICE OF PERSONNEL MANAGEMENT Excepted Service AGENCY: U.S. Office of.... 218. John Berry, Director, U.S. Office of Personnel Management. [FR Doc. 2010-21069 Filed 8-24-10;...

  15. 75 FR 38061 - Airworthiness Directives; Airbus Model A300 B4-600 Series Airplanes; Model A300 B4-600R Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... reinforcement of the junction of frame bases at FR48, FR49 and FR51 to FR53 is necessary to enable the aircraft... (42 500 FC ), it has been concluded that a reinforcement of the junction of frame bases at FR48, FR49... above, this AD requires the reinforcement of the affected junction of frame bases. Required...

  16. 75 FR 61975 - Airworthiness Directives; Airbus Model A300 B4-600 Series Airplanes, Model A300 B4-600R Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-07

    ... a reinforcement of the junction of frame bases at FR48, FR49 and FR51 to FR53 is necessary to enable... (42,500 FC ), it has been concluded that a reinforcement of the junction of frame bases at FR48, FR49... above, this AD requires the reinforcement of the affected junction of frame bases. Required...

  17. Data assimilative twin-experiment in a high-resolution Bay of Biscay configuration: 4DEnOI based on stochastic modeling of the wind forcing

    NASA Astrophysics Data System (ADS)

    Vervatis, V.; Testut, C. E.; De Mey, P.; Ayoub, N.; Chanut, J.; Quattrocchi, G.

    2016-04-01

    A twin-experiment is carried out introducing elements of an Ensemble Kalman Filter (EnKF), to assess and correct ocean uncertainties in a high-resolution Bay of Biscay configuration. Initially, an ensemble of 102 members is performed by applying stochastic modeling of the wind forcing. The target of this step is to simulate the envelope of possible realizations and to explore the robustness of the method at building ensemble covariances. Our second step includes the integration of the ensemble-based error estimates into a data assimilative system adopting a 4D Ensemble Optimal Interpolation (4DEnOI) approach. In the twin-experiment context, synthetic observations are simulated from a perturbed member not used in the subsequent analyses, satisfying the condition of an unbiased probability distribution function against the ensemble by performing a rank histogram. We evaluate the assimilation performance on short-term predictability focusing on the ensemble size, the observational network, and the enrichment of the ensemble by inexpensive time-lagged techniques. The results show that variations in performance are linked to intrinsic oceanic processes, such as the spring shoaling of the thermocline, in combination with external forcing modulated by river runoffs and time-variable wind patterns, constantly reshaping the error regimes. Ensemble covariances are able to capture high-frequency processes associated with coastal density fronts, slope currents and upwelling events near the Armorican and Galician shelf break. Further improvement is gained when enriching model covariances by including pattern phase errors, with the help of time-neighbor states augmenting the ensemble spread.

  18. 77 FR 28243 - Amendment of Class D Airspace; Cocoa Beach, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    .... FAA-2012-0099, Airspace Docket No. 12- ASO-11, published on April 11, 2012 (77 FR 21662), amends Class... Beach, FL, as published in the Federal Register of April 11, 2012 (77 FR 21662) (FR Doc. 2012-8558)...

  19. 75 FR 14441 - General Services Administration; Office of Governmentwide Policy; Submission for Review; Tangible...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... Register at 72 FR 64648, November 16, 2007 and 73 FR 67175, November 13, 2008. Comments were received... over specific reporting requirements in the provisions of existing awards. The response in 73 FR...

  20. 76 FR 58269 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... procedures prescribed in 5 CFR 1320.12. On May 9, 2011 (76 FR 26900), EPA sought comments on this ICR... Manufacturing were proposed on October 4, 2001 (66 FR 50768), and promulgated on October 18, 2002 (67 FR...

  1. 75 FR 53366 - Self-Regulatory Organizations; BATS Exchange, Inc.; Chicago Board Options Exchange, Incorporated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-31

    ... Nos. 62251 (June 10, 2010), 75 FR 34183 (June 16, 2010); 62252 (June 10, 2010), 75 FR 34186 (June 16... FR 51138 (August 18, 2010). The Commission finds it appropriate to designate a longer period...

  2. 76 FR 58300 - Affirmative Decisions on Petitions for Modification Granted in Whole or in Part

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... Affected: 30 CFR 75.1700 (Oil and gas wells). Docket Number: M-2009-005-C. FR Notice: 74 FR 23747 (May 20... CFR 75.1700 (Oil and gas wells). Docket Number: M-2009-006-C. FR Notice: 74 FR 23748 (May 20, 2009.... Regulation Affected: 30 CFR 75.1700 (Oil and gas wells). Docket Number: M-2009-039-C. FR Notice: 74 FR...

  3. Quadrupole moments of high spin isomers in sup 213 Fr, sup 212 Fr, and sup 211 Fr

    SciTech Connect

    Hardeman, F.; Neyens, G.; Scheveneels, G.; Nouwen, R.; S'heeren, G.; Van Den Bergh, M.; Coussement, R. ); Byrne, A.P.; Muesseler, R.; Huebel, H.; Baldsiefen, G. )

    1991-02-01

    The level mixing spectroscopy method has been applied to measure the static quadrupole moments of six isomeric states in {sup 213}Fr, {sup 212}Fr, and {sup 211}Fr ({ital Z}=87). For isomers with the proton configuration {pi}{ital h}{sub 9/2}{sup 4}{ital i}{sub 13/2} a large increase of the quadrupole moment was observed with the removal of neutrons from the closed {ital N}=126 core: {ital Q}(29/2{sup +},{sup 213}Fr)={minus}70(7) {ital e} fm{sup 2}, {ital Q}(15{sup {minus}},{sup 212}Fr)={minus}80(12) {ital e} fm{sup 2}, and {ital Q}(29/2{sup +},{sup 211}Fr)={minus}107(18) {ital e} fm{sup 2}. Quadrupole moments for very high spin states were also measured: {ital Q}(65/2{sup {minus}},{sup 213}Fr)={minus}219(53) {ital e} fm{sup 2}, {ital Q}(27{sup {minus}},{sup 212}Fr)={minus}152(31) {ital e} fm{sup 2}, and {ital Q}(45/2{sup {minus}},{sup 211}Fr) ={minus}198(56) {ital e} fm{sup 2}. The observed values are in good agreement with shell-model calculations, but are lower than that predicted using the deformed-independent particle model. The implantation behavior of Fr in a Tl host is also discussed.

  4. 78 FR 68042 - Petition for Waiver and Notice of Granting the Application for Interim Waiver of Indesit Company...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ..., 2011, DOE published a test procedure final rule (76 FR 1032) to include provisions for testing ventless... waivers for the same type of clothes dryer to Bosch (BSH) (76 FR 33271, June 8, 2011), Miele Appliance, Inc. (Miele) (60 FR 9330, February 17, 1995; 76 FR 17637, March 30, 2011), LG Electronics (73 FR...

  5. A novel minimally invasive, dorsolateral, tubular partial odontoidectomy and autologous bone augmentation to treat dens pseudarthrosis: cadaveric, 3D virtual simulation study and technical report.

    PubMed

    Archavlis, Eleftherios; Serrano, Lucas; Schwandt, Eike; Nimer, Amr; Molina-Fuentes, Moisés Felipe; Rahim, Tamim; Ackermann, Maximilian; Gutenberg, Angelika; Kantelhardt, Sven Rainer; Giese, Alf

    2017-02-01

    OBJECTIVE The goal of this study was to demonstrate the clinical and technical nuances of a minimally invasive, dorsolateral, tubular approach for partial odontoidectomy, autologous bone augmentation, and temporary C1-2 fixation to treat dens pseudarthrosis. METHODS A cadaveric feasibility study, a 3D virtual reality reconstruction study, and the subsequent application of this approach in 2 clinical cases are reported. Eight procedures were completed in 4 human cadavers. A minimally invasive, dorsolateral, tubular approach for odontoidectomy was performed with the aid of a tubular retraction system, using a posterolateral incision and an oblique approach angle. Fluoroscopy and postprocedural CT, using 3D volumetric averaging software, were used to evaluate the degree of bone removal of C1-2 lateral masses and the C-2 pars interarticularis. Two clinical cases were treated using the approach: a 23-year-old patient with an odontoid fracture and pseudarthrosis, and a 35-year-old patient with a history of failed conservative treatment for odontoid fracture. RESULTS At 8 cadaveric levels, the mean volumetric bone removal of the C1-2 lateral masses on 1 side was 3% ± 1%, and the mean resection of the pars interarticularis on 1 side was 2% ± 1%. The median angulation of the trajectory was 50°, and the median distance from the midline of the incision entry point on the skin surface was 67 mm. The authors measured the diameter of the working channel in relation to head positioning and assessed a greater working corridor of 12 ± 4 mm in 20° inclination, 15° contralateral rotation, and 5° lateral flexion to the contralateral side. There were no violations of the dura. The reliability of C-2 pedicle screws and C-1 lateral mass screws was 94% (15 of 16 screws) with a single lateral breach. The patients treated experienced excellent clinical outcomes. CONCLUSIONS A minimally invasive, dorsolateral, tubular odontoidectomy and autologous bone augmentation combined with C1

  6. Long-term Outcomes and Quality of Life of 186 Patients With Primary Parotid Carcinoma Treated With Surgery and Radiotherapy at the Daniel den Hoed Cancer Center

    SciTech Connect

    Al-Mamgani, Abrahim; Rooij, Peter van; Verduijn, Gerda M.; Meeuwis, Cees A.; Levendag, Peter C.

    2012-09-01

    Purpose: To assess the outcomes, toxicity, and quality of life (QOL) of patients with primary parotid carcinoma treated with surgery and postoperative radiotherapy at the Daniel den Hoed Cancer Center. Methods and Materials: Between 1995 and 2010, 186 patients with parotid carcinoma were treated with parotidectomy with or without neck dissection, followed by radiotherapy. Elective nodal irradiation (ENI) was applied to high-risk, node-negative disease. End points were locoregional control (LRC), disease-free survival (DFS), cause-specific survival (CSS), and overall survival (OS), late toxicity, and QOL. Results: After a median follow-up of 58 months (range, 4-172 months), the 5-year Kaplan-Meier estimates for LRC, DFS, CSS, and OS were 89%, 83%, 80%, and 68%, respectively. Forty-five events were reported: 24 distant metastases (DM) and 21 locoregional failures (LRF). Event-free survival rates by histological types were 89%, 78%, 76%, 74%, and 70% for acinic cell, mucoepidermoid, adenoid cystic, adenocarcinoma, and squamous cell carcinoma, respectively. More LRF were reported in patients with squamous cell and high-grade mucoepidermoid carcinoma (21% and 19%, respectively) than in patients with other histological types (p = 0.04) and more DM in patients with adenoid cystic and adenocarcinoma (20% and 19%, respectively) than in patients with other types (p = 0.03). None of the high-risk node-negative patients who received ENI developed regional failure. On multivariate analysis, T stage, N stage, grade, and presence of perineural invasion and facial paralysis correlated significantly with DFS. The 5-year cumulative incidence of grade {>=}2 late toxicity was 8%. QOL scores deteriorate during and shortly after treatment but returned in almost all scales to baseline scores within 6 months. Conclusions: Of the entire group, surgery and postoperative radiotherapy resulted in excellent outcomes with minimal side effects and preservation of good QOL scores. However, in

  7. 78 FR 79333 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    .... Discussion On June 9, 2000, we issued AD 2000-12-12, Amendment 39-11790 (65 FR 39072, June 23, 2000). That AD... superseded AD 95-10-03, Amendment 39-9220 (60 FR 25604, May 12, 1995). Since we issued AD 2000-12-12, Amendment 39-11790 (65 FR 39072, June 23, 2000), The European Aviation Safety Agency (EASA), which is...

  8. 78 FR 79283 - Community Reinvestment Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... CRA purposes by the OCC, Board, and FDIC on August 2, 2005, effective September 1, 2005. 70 FR 44256... Act (HMDA). 70 FR 12148 (Mar. 11, 2005). See 12 U.S.C. 2808; 12 CFR 203.2(e)(1). On March 22, 2007... other federal banking agencies in its CRA rule previously set forth at 12 CFR 563e. 72 FR 13429 (Mar....

  9. 76 FR 61342 - Foreign-Trade Zone 72 Temporary/Interim Manufacturing Authority Brevini Wind USA, Inc., (Wind...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ... Board Orders 1347 (69 FR 52857, 8/30/04) and 1480 (71 FR 55422, 9/22/06), including notice in the Federal Register inviting public comment (76 FR 43260, 7/20/2011). The FTZ staff examiner reviewed...

  10. 77 FR 34935 - Foreign-Trade Zone 161; Temporary/Interim Manufacturing Authority; Siemens Energy, Inc., (Wind...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... with T/IM procedures, as authorized by FTZ Board Orders 1347 (69 FR 52857, 8/30/04) and 1480 (71 FR 55422, 9/22/06), including notice in the Federal Register inviting public comment (77 FR 20782,...

  11. 76 FR 29279 - Calvert Cliffs 3 Nuclear Project, LLC and Unistar Nuclear Operating Services, LLC; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... the Federal Register on April 21, 2010 (76 FR 20867), and by the U.S. Environmental Protection Agency on April 26, 2010 and April 30, 2010 (76 FR 21625 and 76 FR 22778). The purpose of this notice is...

  12. 75 FR 62111 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-07

    ..., 1993; 58 FR 10562). KPAC.01, Classified Container Information Form DA 727 (February 22, 1993; 58 FR 10562). KDCE.03, DA Form 727 Classified Container Information File 503-02 (February 22, 1993; 58...

  13. 77 FR 19313 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-30

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... Richmond 77 FR 3493: March 15, 2012. Zoo. January 24, 2012. 694126 National 76 FR 80384; March 15,...

  14. 77 FR 34943 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ...-01) The Graduate Fellowship Programs Participants Study, 70 FR 51348-51351 (August 30, 2005). 2. (18... Graduate Fellowship Programs Participants Study, 70 FR 51348- 51351 (August 30, 2005). 18-17-02 Follow...

  15. 77 FR 47787 - Additional Requirements for Charitable Hospitals; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-10

    ...) that was published in the Federal Register on Tuesday, June 26, 2012 (77 FR 38148). The proposed... subject of FR Doc. 2012-15537, is corrected as follows: 1. On page 38153, in the preamble, column 1,...

  16. 78 FR 37565 - Endangered Species; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ..., 2012. 91700A Reptile Wrangler LLC... 77 FR 74506; December January 17, 2013. 14, 2012. 89184A Cinco... 12777; February April 11, 2013. 25, 2013. 034669 Randar's Reptiles...... 78 FR 12777; February April...

  17. Application of DEN refinement and automated model building to a difficult case of molecular-replacement phasing: the structure of a putative succinyl-diaminopimelate desuccinylase from Corynebacterium glutamicum.

    PubMed

    Brunger, Axel T; Das, Debanu; Deacon, Ashley M; Grant, Joanna; Terwilliger, Thomas C; Read, Randy J; Adams, Paul D; Levitt, Michael; Schröder, Gunnar F

    2012-04-01

    Phasing by molecular replacement remains difficult for targets that are far from the search model or in situations where the crystal diffracts only weakly or to low resolution. Here, the process of determining and refining the structure of Cgl1109, a putative succinyl-diaminopimelate desuccinylase from Corynebacterium glutamicum, at ∼3 Å resolution is described using a combination of homology modeling with MODELLER, molecular-replacement phasing with Phaser, deformable elastic network (DEN) refinement and automated model building using AutoBuild in a semi-automated fashion, followed by final refinement cycles with phenix.refine and Coot. This difficult molecular-replacement case illustrates the power of including DEN restraints derived from a starting model to guide the movements of the model during refinement. The resulting improved model phases provide better starting points for automated model building and produce more significant difference peaks in anomalous difference Fourier maps to locate anomalous scatterers than does standard refinement. This example also illustrates a current limitation of automated procedures that require manual adjustment of local sequence misalignments between the homology model and the target sequence.

  18. Evaluation of Coatings for FR-4 Fiberglass Epoxy Composite Probes

    DTIC Science & Technology

    2014-01-01

    The probe is fabricated from a composite material ( FR -4) composed of woven fiberglass cloth with a flame-resistant epoxy resin binder. FR -4 is a...Evaluation of Coatings for FR -4 Fiberglass Epoxy Composite Probes by Faye R. Toulan, David P. Flanagan, John J. La Scala, and Daniel M. De...5069 ARL-TR-6771 January 2014 Evaluation of Coatings for FR -4 Fiberglass Epoxy Composite Probes Faye R. Toulan Dynamic Science, Inc

  19. 78 FR 40225 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Order Approving a Proposed Rule Change...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ..., 75 FR at 13165- 13166. \\15\\ See Notice, 78 FR at 31995. The Exchange shall enter into a plan pursuant...\\ \\17\\ See Notice, 78 FR at 31995. \\18\\ See id. In the past, the Commission has expressed concern that... 13165; and Notice, 78 FR at 31995. IV. Conclusion It is therefore ordered, pursuant to Section...

  20. 78 FR 2304 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Order Approving a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ... (November 19, 2012), 77 FR 70511 (November 26, 2012) (SR-CBOE-2012-109) (``Notice''). II. Description of the... corresponding order to the other trading center. \\4\\ See Notice, 77 FR at 70511. \\5\\ See Notice, 77 FR at 70511..., 77 FR at 70512. For examples of some of the circumstances in which the Exchange may decide to...

  1. 75 FR 69653 - Energy Conservation Program for Consumer Products: Decision and Order Granting a Waiver to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-15

    ...] [FR Doc No: 2010-28646] DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy [Case No... 22, 2006. 71 FR 48913. DOE received one comment on the Whirlpool petition, from a private citizen who... Samsung's interim waivers on September 16, 2010. (75 FR 57915; 75 FR 57937). Table 5.1 of Appendix...

  2. 75 FR 10168 - Information on Foreign Chain of Distribution for Ephedrine, Pseudoephedrine, and Phenylpropanolamine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    ... List I Chemicals'' [Docket No. DEA-293, RIN 1117- AB08] (72 FR 37439, July 10, 2007; 73 FR 73549... 10168-10172] [FR Doc No: 2010-4716] DEPARTMENT OF JUSTICE Drug Enforcement Administration 21 CFR Part... Proposed Rulemaking published in the Federal Register on March 31, 2008 (73 FR 16793). The...

  3. 78 FR 69612 - Negotiated Rulemaking Committee, Negotiator Nominations and Schedule of Committee Meetings-Title...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... Federal Register (77 FR 25658) announcing our intent to establish a negotiated rulemaking committee under... in the Federal Register (78 FR 22467), which we corrected on April 30, 2013 (78 FR 25235), announcing... the Federal Register (78 FR 27880) the addition of a fourth hearing. The hearings were held on May...

  4. 78 FR 79619 - Patient Protection and Affordable Care Act; Program Integrity: Exchange, Premium Stabilization...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ...] [Pages 79619-79620] [FR Doc No: 2013-31319] DEPARTMENT OF HEALTH AND HUMAN SERVICES 45 CFR Part 155 [CMS.... Background In FR Doc. 2013-25326 of October 30, 2013 (78 FR 65046), final rule entitled ``Patient Protection... Standards; Amendments to the HHS Notice of Benefit and Payment Parameters for 2014 (78 FR 65046), there...

  5. 77 FR 54942 - Self-Regulatory Organizations; Boston Stock Exchange Clearing Corporation; NASDAQ OMX BX, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... Nos. 67293 (June 28, 2012), 77 FR 39751 (July 5, 2012) (SR-NASDAQ-2012-072) (the ``NASDAQ Notice''); 67433 (July 13, 2012), 77 FR 42522 (July 19, 2012) (SR- BX-2012-052); 67434 (July 13, 2012), 77 FR 42524 (July 19, 2012) (SR-Phlx-2012-95); 67487 (July 23, 2012), 77 FR 44301 (July 27, 2012)...

  6. 76 FR 34633 - Medicare Program; Proposed Changes to the Hospital Inpatient Prospective Payment Systems for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    .... SUPPLEMENTARY INFORMATION: I. Background In FR Doc. 2011-9644 of May 5, 2011 (76 FR 25788), there were a number...InpatientPPS/01_overview.asp ). III. Correction of Errors In FR Doc. 2011-9644 of May 5, 2011 (76 FR...

  7. 78 FR 39730 - Medicare Program; Notification of Closure of Teaching Hospitals and Opportunity To Apply for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... INFORMATION CONTACT: Miechal Lefkowitz, (212)-616-2517. SUPPLEMENTARY INFORMATION: I. Background In FR Doc. 2013-12952 of May 31, 2013 (78 FR 32663), there was a typographical error that is identified and.... Correction of Errors In FR Doc. 2013-12952 of May 31, 2013 (78 FR 32663), make the following corrections:...

  8. 75 FR 57849 - Maintenance of Incombustible Content of Rock Dust in Underground Coal Mines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ...- Hands-on training for miners in the use of self-contained self-rescue (SCSR) devices (52 FR 24373, June 30, 1987); Training and mine evacuation procedures for underground coal mines (67 FR 76658, Dec. 12... emergency evacuations (71 FR 12252, Mar. 9, 2006); and Sealing of abandoned areas (72 FR 28797, May 22,...

  9. 78 FR 19164 - Amendments to Compliance Certification Content Requirements for State and Federal Operating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... and 71 due to an editing error. This error occurred in a June 27, 2003, final rule (68 FR 38517... was originally promulgated on July 21, 1992 (57 FR 32250), and the part 71 rule on July 1, 1996 (61 FR... requirements of parts 70 and 71 in the context of a CAM rulemaking on October 22, 1997 (62 FR 54899). The...

  10. 78 FR 26255 - Approval and Promulgation of Air Quality Implementation Plans; Texas; Approval of Texas Low...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... Texas Low Emission Diesel (TxLED) fuel program was initially approved by EPA on November 14, 2001 (66 FR 57196). It was revised on April 6, 2005 (70 FR 17321), October 6, 2005 (70 FR 58325), and October 24, 2008 (73 FR 63378). The TxLED fuel is similar to CARB (California Air Resources Board) diesel and...

  11. 78 FR 38970 - California State Nonroad Engine Pollution Control Standards; Within-the-Scope Determination for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... Act, or are not subject to CAA preemption. \\1\\ 74 FR 3030 (January 16, 2009). \\2\\ California Air... opportunity for public hearing and comment on CARB's request. \\11\\ 78 FR 721 (January 4, 2013). Although CARB... new locomotives or new engines used in locomotives. \\14\\ 59 FR 36969 (July 20, 1994). \\15\\ 62 FR...

  12. 7 CFR 29.3068 - Tannish-red color (FR).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29,...

  13. 7 CFR 29.3068 - Tannish-red color (FR).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan. [24 FR 8771, Oct. 29,...

  14. 78 FR 62648 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    .... Applicant Federal Register notice Permit issuance date Endangered Species 10814B Larry Bell 78 FR 45954; July 30, September 12, 2013. 2013. 13216B Anthony Gaglio 78 FR 50083; August 16, September 25, 2013. 2013. 13270B Shane Erving 78 FR 50083; August 16, September 25, 2013. 2013. Marine Mammals 056326...

  15. 78 FR 14819 - Endangered Species; Marine Mammal; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-07

    ... application Permit No. Applicant Federal Register notice Permit issuance date 88568A The Living Desert 77 FR 66476; November 5, February 12, 2013. 2012. 77706A LBMI, L.P. doing business 77 FR 72882; December 6, February 19, 2013. as El Coyote Ranch. 2012. 75897A American Museum of Natural 77 FR 72882; December...

  16. 76 FR 35966 - Amendment of Class E Airspace; Cocoa, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... Merritt Island Airport, Cocoa, FL (75 FR 21266) Docket No. FAA-2011-0070. Interested parties were invited... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR..., 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The...

  17. 76 FR 53129 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ...'s functions; including whether the information has practical utility; b. The accuracy of the Federal.... Reporters: FR Y-6: Top-tier domestic BHCs; FR Y-7: FBOs. Estimated annual reporting hours: FR Y-6: 28,796... (12 CFR 211.13(c), 225.5(b)). Individual respondent data are not considered confidential....

  18. Cross Sections: No 6 Hold Section at Fr 178 Looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Cross Sections: No 6 Hold Section at Fr 178 Looking Fwd, No 7 Hold Section at No 154 Looking Fwd, No 7 Hold Section at Fr 195 Looking Fwd Showing Trans 194, No 7 Hold Section at Fr 198 Looking Fwd - General John Pope, Suisun Bay Reserve Fleet, Benicia, Solano County, CA

  19. 78 FR 12780 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... endangered species, we found that (1) The application was filed in good faith, (2) The granted permit would... Moore 77 FR 66476; January 14, 2013. November 5, 2012. 84872A Palm Beach Zoo at 77FR 66476; November... Islands November 16, 2012. Regional Office. 89103A Dallas Zoo 77FR 68809; November February 12, 2013....

  20. 77 FR 64711 - Airworthiness Directives; The Boeing Company Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... Nesemeier, Senior Aerospace Engineer, Systems and Equipment Branch, ANM-130S, FAA, Seattle Aircraft... on the SNPRM (77 FR 31758, May 30, 2012) and the FAA's response to each comment. Support for the SNPRM (77 FR 31758, May 30, 2012) Boeing supports the SNPRM (77 FR 31758, May 30, 2012). Requests To...

  1. 76 FR 4936 - Granular Polytetrafluoroethylene Resin From Italy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... on granular PTFE resin from Italy and Japan (75 FR 67082-67083 and 67105-67108, November 1, 2010... correction of the initiation notice on January 12, 2011 (76 FR 2083). On January 13, 2011, Commerce notified... 17, 2011; Responses to the 13 items requested in the Commission's notice of institution (75 FR...

  2. 75 FR 67105 - Granular Polytetrafluoroethylene Resin From Italy and Japan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-01

    ...), as most recently amended at 74 FR 2847 (January 16, 2009). \\1\\ No response to this request for... granular polytetrafluoroethylene resin from Japan (53 FR 32267). On August 30, 1988, Commerce issued an antidumping duty order on imports of granular polytetrafluoroethylene resin from Italy (53 FR...

  3. 76 FR 72968 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    .... Applicant Federal Register notice Permit issuance date 46259A Jefferey Spivery...... 76 FR 54480; September 1, November 2, 2011. 2011. 52683A Carlos Ramirez........ 76 FR 60862; September 30, November 3, 2011. 2011. 50923A Woolsey Caye 76 FR 60862; September 30, November 3, 2011. 2011. 49805A Graham Banes 76...

  4. 77 FR 37000 - Marine Mammals; File No. 814-1899

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... [Federal Register Volume 77, Number 119 (Wednesday, June 20, 2012)] [Notices] [Page 37000] [FR Doc... (No. 814-1899), issued on July 18, 2007 (72 FR 40285), authorized the collection and receipt of parts... Conservation Division, Office of Protected Resources, National Marine Fisheries Service. [FR Doc....

  5. 78 FR 79329 - Airworthiness Directives; Bombardier, Inc. Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... (70 FR 43032, July 26, 2005). That AD required actions intended to address an unsafe condition on the products listed above. Since we issued AD 2005-15-04, Amendment 39-14193 (70 FR 43032, July 26, 2005... that are required by AD 2005-15-04, Amendment 39-14193 (70 FR 43032, July 26, 2005), and retained...

  6. 7 CFR 29.1044 - Orange Red (FR).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Orange Red (FR). 29.1044 Section 29.1044 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1044 Orange Red (FR). A yellowish red. [42 FR 21092, Apr. 25, 1977. Redesignated at 47...

  7. 7 CFR 29.1044 - Orange Red (FR).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Orange Red (FR). 29.1044 Section 29.1044 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1044 Orange Red (FR). A yellowish red. [42 FR 21092, Apr. 25, 1977. Redesignated at 47...

  8. 78 FR 79660 - Enhancing Agricultural Coexistence; Extension of Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Notices] [Page 79660] [FR... on November 4, 2013 (78 FR 65960) is extended. We will consider all comments that we receive on or...: On November 4, 2013, we published in the Federal Register (78 FR 65960-65962, Docket No....

  9. 78 FR 80379 - Federal Acquisition Regulation; Trade Agreements Thresholds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ...] [Pages 80379-80381] [FR Doc No: 2013-31151] DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION... (78 FR 76700), the United States Trade Representative published new procurement thresholds. The United... and Remedies (DEC 2013) * * * * * [FR Doc. 2013-31151 Filed 12-30-13; 8:45 am] BILLING CODE 6820-EP-P...

  10. 77 FR 3391 - Changes in Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... 3391-3393] [FR Doc No: 2012-1318] DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency... 12866 of September 30, 1993, Regulatory Planning and Review, 58 FR 51735. Executive Order 13132... et seq.; Reorganization Plan No. 3 of 1978, 3 CFR, 1978 Comp., p. 329; E.O. 12127, 44 FR 19367, 3...

  11. Matthias Falter und die frühe Halbleitertechnik in der DDR

    NASA Astrophysics Data System (ADS)

    Dittmann, Frank

    Nach einer ganzen Reihe von Vorarbeiten weltweit1 konnten im Dezember 1947 die amerikanischen Physiker Walter H. Brattain, John Bardeen und William Shockley in den Bell Laboratories den Transistoreffekt demonstrieren. Damit legten sie den Grundstein für die Mikroelektronik als Basistechnologie des Informationszeitalters.

  12. 78 FR 52956 - Proposed Flood Hazard Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... SECURITY Federal Emergency Management Agency Proposed Flood Hazard Determinations AGENCY: Federal Emergency... Register (78 FR 36220-36222) a proposed flood hazard determination notice that contained an erroneous table... FR 36220. The table provided here represents the proposed flood hazard determinations and...

  13. 75 FR 68755 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ...] [FR Doc No: 2010-28354] COMMISSION ON CIVIL RIGHTS Sunshine Act Notice AGENCY: United States Commission on Civil Rights. ACTION: Notice of meeting cancellation. SUMMARY: On October 12, 2010 (75 FR 63144-63145), the U.S. Commission on Civil Rights announced a business meeting to be held on Friday,...

  14. 77 FR 37043 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... [Federal Register Volume 77, Number 119 (Wednesday, June 20, 2012)] [Notices] [Page 37043] [FR Doc No: 2012-15232] FEDERAL ELECTION COMMISSION Sunshine Act Meeting AGENCY: Federal Election Commission. FEDERAL REGISTER CITATION OF PREVIOUS ANNOUNCMENT: 77 FR 36275 (June 18, 2012). DATE AND TIME:...

  15. 77 FR 37043 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-20

    ... [Federal Register Volume 77, Number 119 (Wednesday, June 20, 2012)] [Notices] [Page 37043] [FR Doc No: 2012-15194] FEDERAL ELECTION COMMISSION Sunshine Act Meeting AGENCY: Federal Election Commission. Federal Register Citation of Previous Announcement: 77 FR 35680 (June 14, 2012). DATE AND TIME:...

  16. 78 FR 78769 - Medical Body Area Networks

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ...), 95.1217(a)(3), 95.1223 and 95.1225 published at 78 FR 55715, September 11, 2012 are effective... First Report and Order, FCC 12-54, published at 78 FR 55715, September 11, 2012. The OMB Control...

  17. 77 FR 3236 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-23

    ... [Federal Register Volume 77, Number 14 (Monday, January 23, 2012)] [Notices] [Pages 3236-3237] [FR Doc No: 2012-1142] DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2012-OS-0004... Officer, Department of Defense. [FR Doc. 2012-1142 Filed 1-20-12; 8:45 am] BILLING CODE 5001-06-P...

  18. 62 FR 65388 - Occupational Exposure to Tuberculosis

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-12-12

    ... Tuberculosis AGENCY: Occupational Safety and Health Administration (OSHA), Labor ACTION: Proposed rule... tuberculosis (62 FR 54160). An informal public hearing was scheduled for Washington, D.C., and deadlines were... a new standard for occupational exposure to tuberculosis on October 17, 1997 (62 FR 54160)....

  19. 75 FR 51444 - Procurement List Additions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ..., CT. Contracting Activity: Department of Defense, Defense Contract Management Agency (DCMA), Boston... 10800, 1421 Jefferson Davis Highway, Arlington, Virginia 22202-3259. FOR FURTHER INFORMATION CONTACT... . SUPPLEMENTARY INFORMATION: Additions On 6/4/2010 (75 FR 31768-31769); 6/11/2010 (75 FR 33270-33271); 6/...

  20. 78 FR 79712 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Proposed Rules] [Page 79712] [FR Doc No: 2013-31243] SECURITIES AND EXCHANGE COMMISSION Proposed Collection; Comment Request Upon..., Secretary. [FR Doc. 2013-31243 Filed 12-30-13; 8:45 am] BILLING CODE 8011-01-P...

  1. 78 FR 79714 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Proposed Rules] [Page 79714] [FR Doc No: 2013-31240] SECURITIES AND EXCHANGE COMMISSION Proposed Collection; Comment Request Upon.... [FR Doc. 2013-31240 Filed 12-30-13; 8:45 am] BILLING CODE 8011-01-P...

  2. 78 FR 79712 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Proposed Rules] [Pages 79712-79714] [FR Doc No: 2013-31239] SECURITIES AND EXCHANGE COMMISSION Proposed Collection; Comment..., Secretary. [FR Doc. 2013-31239 Filed 12-30-13; 8:45 am] BILLING CODE 8011-01-P...

  3. 78 FR 79711 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Proposed Rules] [Pages 79711-79712] [FR Doc No: 2013-31241] SECURITIES AND EXCHANGE COMMISSION Proposed Collection; Comment..._Mailbox@sec.gov . Dated: December 24, 2013. Elizabeth M. Murphy, Secretary. [FR Doc. 2013-31241 Filed...

  4. 78 FR 79714 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Proposed Rules] [Pages 79714-79715] [FR Doc No: 2013-31242] SECURITIES AND EXCHANGE COMMISSION Proposed Collection; Comment.... Elizabeth M. Murphy, Secretary. [FR Doc. 2013-31242 Filed 12-30-13; 8:45 am] BILLING CODE 8011-01-P...

  5. 78 FR 79714 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Proposed Rules] [Page 79714] [FR Doc No: 2013-31238] SECURITIES AND EXCHANGE COMMISSION Proposed Collection; Comment Request Upon...@sec.gov . Dated: December 24, 2013. Elizabeth M. Murphy, Secretary. [FR Doc. 2013-31238 Filed...

  6. 75 FR 47717 - Content of Periodicals Mail

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-09

    ... Periodicals Mail'' published by the Federal Register on July 20, 2010 (75 FR 41989-41991) is revised to... March 27, 1995, the Postal Service published a final rule in the Federal Register (60 FR 10021-10029... Part 111 Content of Periodicals Mail AGENCY: Postal Service\\TM\\ ACTION: Final rule; revised....

  7. The dating of the ornithological section of Middendorff's Reise in den äussersten Norden und Osten Sibiriens, with comments on the nomenclature of Pallas's Bunting Emberiza pallasi Cabanis (Aves: Emberizidae).

    PubMed

    Mlíkovský, Jiří

    2014-05-14

    Middendorff's work on the Säugethiere, Vögel und Amphibien, published as part 2 of volume 2 of his Reise in den äussersten Norden und Osten Sibiriens, was variably dated from 1851, 1852 or 1853. I document that the work was published shortly before 15 December 1852 and I recommend using this date for the purposes of zoological nomenclature.Due to this, Emberiza polaris Middendorff, 1852 has precedence over Cynchramus pallasi Cabanis, 1853. This bunting species thus should be called Emberiza polaris and its four subspecies should be called Emberiza polaris polaris Middendorff, 1852, E. polaris minor Middendorff, 1852, E. polaris pallasi (Cabanis, 1853) and E. polaris lydiae Portenko, 1929. 

  8. 75 FR 19199 - Airworthiness Directives; Airbus Model A330-200, A330-300, and A340-300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-14

    ... that in the area between frame (FR) C53.9 and FR C55 RH , the distance between the route 9R of the In... in the area between frame (FR) C53.9 and FR C55 RH , the distance between the route 9R of the In... information (MCAI) states: It was noticed in production that in the area between frame (FR) C53.9 and FR...

  9. 78 FR 55056 - Approval for Manufacturing (Production) Authority; Foreign-Trade Zone 141; Firth Rixson, Inc. d/b...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-09

    ..., filed 4-29-2011); Whereas, notice inviting public comment has been given in the Federal Register (76 FR 25300-25301, 5-4-2011; 77 FR 43572-43573, 7-25- 2012; 78 FR 2658, 1-14-2013; 78 FR 9033, 2-7-2013)...

  10. 77 FR 43048 - Foreign-Trade Zone 8-Toledo, OH; Application for Reorganization and Expansion Under Alternative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... Order 92, 38 FR 3015, 1/31/1973); January 11, 1985 (Board Order 277, 50 FR 2702, 1/18/1985); August 19... FR 9613-9614, 2/28/2005); August 23, 2005 (Board Order 1408, 70 FR 51335, 8/30/2005); and, August 5...; Site 5 (167 acres)--Ohio Northern Global Distribution and Business Training Center, 6722 Commodore...

  11. 78 FR 2302 - Self-Regulatory Organizations; C2 Options Exchange, Incorporated; Order Approving a Proposed Rule...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ... Act Release No. 68260 (November 19, 2012), 77 FR 70496 (November 26, 2012) (SR-C2-2012-038) (``Notice... FR at 70496. \\5\\ See Notice, 77 FR at 70496-97 n.5, n.9, and accompanying text. In its proposal, C2..., routing brokers, or another exchange.\\7\\ \\6\\ See Notice, 77 FR at 70497. For examples of some of...

  12. 78 FR 78720 - Deferral of Compliance Date: Full-Service Intelligent Mail Barcode Requirement To Qualify for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... compliance date of the relevant portions of the final rule published April 18, 2013 (78 FR 23137) is delayed... automation prices, previously published on April 18, 2013, in a final rule in the Federal Register (78 FR..., 78 FR 23146-23148. All other requirements that were published in the Federal Register (78 FR...

  13. 78 FR 40043 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Reef Fish Fishery of the Gulf of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... published a final rule to implement Gulf Reef Fish Amendment 37 (78 FR 27084). That final rule, in part... November 10, 2012 (77 FR 28308, May 14, 2012), and extended through May 15, 2013 (77 FR 67303, November 9... opportunity to comment on the proposed rule for Gulf Reef Fish Amendment 37 (78 FR 10122, February 13,...

  14. 78 FR 44685 - Amendments to the 2013 Mortgage Rules Under the Real Estate Settlement Procedures Act (Regulation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... Final Rule), 78 FR 6407 (Jan. 30, 2013). \\2\\ Mortgage Servicing Rules Under the Real Estate Settlement... Final Rules), 78 FR 10695 (Feb. 14, 2013) (Regulation X), 78 FR 10901 (Feb. 14, 2013) (Regulation Z). \\3\\ Amendments to the 2013 Escrows Final Rule under the Truth in Lending Act (Regulation Z), 78 FR 30739 (May...

  15. 75 FR 69484 - Self-Regulatory Organizations; BATS Exchange, Inc.; NASDAQ OMX BX, Inc.; Chicago Board Options...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-12

    ... Release Nos. 62945 (September 20, 2010), 75 FR 58460 (September 24, 2010) (SR-BATS-2010-025); 62954 (September 20, 2010), 75 FR 59305 (September 27, 2010) (SR-BX- 2010-66); 62951 (September 20, 2010), 75 FR 59309 (September 27, 2010) (SR-CBOE-2010-087); 62949 (September 20, 2010), 75 FR 59315 (September...

  16. 78 FR 60937 - Joint Industry Plan; Order Approving the Fifth Amendment to the National Market System Plan to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ...\\ See Securities Exchange Act Release No. 70274 (August 27, 2013), 78 FR 54305 (``Notice''). II... (June 10, 2010), 75 FR 34183 (June 16, 2010) (SR-FINRA-2010-025); 62883 (September 10, 2010), 75 FR... (February 20, 2013), 78 FR 13113 (February 26, 2013). B. Fifth Amendment to the Plan The Fifth...

  17. 78 FR 18246 - Implementation of the Middle Class Tax Relief and Job Creation Act of 2012; Establishment of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... these requirements. DATES: 47 CFR 1.80 and 64.1202, published at 77 FR 71131, November 29, 2012, and at 78 FR 10099, February 13, 2013, are effective March 26, 2013. FOR FURTHER INFORMATION CONTACT..., FCC 12- 129, published at 77 FR 71131, November 29, 2012, and at 78 FR 10099, February 13, 2013....

  18. 77 FR 72846 - California State Nonroad Engine Pollution Control Standards; In-Use Portable Diesel Engines 50...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-06

    ... FR 36969 (July 20, 1994). \\16\\ See 62 FR 67733 (December 30, 1997). The applicable regulations, now... the California standard. \\17\\ See 59 FR 36969 (July 20, 1994). In order to be consistent with section... EPA review of the State decision to be a narrow one.'' \\22\\ \\22\\ See, e.g., 40 FR 21102-103 (May...

  19. A polynomial f(R) inflation model

    SciTech Connect

    Huang, Qing-Guo

    2014-02-01

    Motivated by the ultraviolet complete theory of quantum gravity, for example the string theory, we investigate a polynomial f(R) inflation model in detail. We calculate the spectral index and tensor-to-scalar ratio in the f(R) inflation model with the form of f(R) = R + (R{sup 2})/6M{sup 2} + (λn)/2n (R{sup n})/(3M{sup 2}){sup n-1}. Compared to Planck 2013, we find that R{sup n} term should be exponentially suppressed, i.e. |λ{sub n}|∼<10{sup −2n+2.6}.

  20. 77 FR 59339 - Contractor Qualifications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-27

    ... [Federal Register Volume 77, Number 188 (Thursday, September 27, 2012)] [Rules and Regulations] [Page 59339] [FR Doc No: 2012-23905] DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 209 Contractor Qualifications CFR Correction In Title 48 of the Code of Federal...

  1. 75 FR 10692 - Maritime Communications

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 80 Maritime Communications ACTION: Final rule; correction. SUMMARY: The Federal Communications Commission published in the Federal Register of February 2, 2010 (75 FR 5241), a document in...

  2. 78 FR 20244 - Product Valuation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Office of Natural Resources Revenue 30 CFR Part 1206 Product Valuation CFR Correction In FR Doc. 2013... ``Surface Mining Reclamation and Enforcement'' is corrected to read ``Office of Natural Resources...

  3. Wormhole solutions in f(R) gravity satisfying energy conditions

    NASA Astrophysics Data System (ADS)

    Mazharimousavi, S. Habib; Halilsoy, M.

    2016-10-01

    Without reference to exotic sources construction of viable wormholes in Einstein’s general relativity remained ever a myth. With the advent of modified theories, however, specifically the f(R) theory, new hopes arose for the possibility of such objects. From this token, we construct traversable wormholes in f(R) theory supported by a fluid source which respects at least the weak energy conditions. We provide an example (Example 1) of asymptotically flat wormhole in f(R) gravity without ghosts.

  4. 77 FR 56607 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... conference call is open to the public. The following business will be conducted: Finish reviewing project..., Forest Supervisor. [FR Doc. 2012-22531 Filed 9-12-12; 8:45 am] BILLING CODE 3410-11-P...

  5. 77 FR 62237 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-12

    ...: Open. MATTERS TO BE CONSIDERED: The Commission will consider and act upon the following in open session..., Administrative Assistant. [FR Doc. 2012-25234 Filed 10-10-12; 11:15 am] BILLING CODE 6735-01-P...

  6. 76 FR 63601 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ...: 624 Ninth Street, NW., Room 540, Washington, DC 20425. Meeting Agenda This meeting is open to the..., 2011. Kimberly A. Tolhurst, Senior Attorney-Advisor. [FR Doc. 2011-26583 Filed 10-11-11; 11:15...

  7. 76 FR 30326 - Proposed Subsequent Arrangement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... Nonproliferation and International Security, National Nuclear Security Administration, Department of Energy. ACTION... Nuclear Security Administration, Department of Energy. Telephone: 202-586-3806 or e- mail: Sean.Oehlbert... Energy. Anne M. Harrington, Deputy Administrator, Defense Nuclear Nonproliferation. [FR Doc....

  8. 77 FR 28250 - Entity List Additions; Corrections

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... General Trading, Office No. 205, Platinum Business Center, Baghdad Street, Al-Nahda 2, Al-Qusais, Dubai, U.... * * * * * * * Zurmat General Trading, For all items Presumption of 77 FR 25055, Office No. 205, Platinum subject to...

  9. 75 FR 45562 - Enhancing Airline Passenger Protections

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ... travel for persons with peanut allergies. See 75 FR 32318 (June 8, 2010). Comments on the matters... coordination regarding the proposals. Accordingly, the Department finds that good cause exists to extend...

  10. 77 FR 22804 - Sunshine Act Meeting; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-17

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Sunshine Act Meeting; Correction AGENCY HOLDING THE MEETING: United States International Trade Commission. Federal Register CITATION OF PREVIOUS ANNOUNCEMENT: 77 FR 22344. ORIGINALLY PUBLISHED TIME...

  11. Loop quantum f(R) theories

    NASA Astrophysics Data System (ADS)

    Zhang, Xiangdong; Ma, Yongge

    2011-09-01

    As modified gravity theories, the four-dimensional metric f(R) theories are cast into connection-dynamical formalism with real su(2) connections as configuration variables. This formalism enables us to extend the nonperturbative loop quantization scheme of general relativity to any metric f(R) theories. The quantum kinematical framework of f(R) gravity is rigorously constructed, where the quantum dynamics can be launched. Both Hamiltonian constraint operator and master constraint operator for f(R) theories are well defined. Our results show that the nonperturbative quantization procedure of loop quantum gravity are valid not only for general relativity but also for a rather general class of four-dimensional metric theories of gravity.

  12. 78 FR 67201 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... call on hold if doing so will trigger recorded music or other sound. From time to time, the presiding... sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov . ACCESSIBILITY: LSC complies with the...

  13. 78 FR 30339 - Sunshine Act Meeting Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ..., please refrain from placing the call on hold if doing so will trigger recorded music or other sound. From.... Questions may be sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov . ACCESSIBILITY: LSC complies...

  14. 78 FR 39781 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... call on hold if doing so will trigger recorded music or other sound. From time to time, the Chair may... may be sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov . Accessibility: LSC complies with...

  15. 78 FR 36602 - Sunshine Act Meeting; Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-18

    ..., please refrain from placing the call on hold if doing so will trigger recorded music or other sound. From... sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov . ACCESSIBILITY: LSC complies with the...

  16. 78 FR 33114 - Sunshine Act Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-03

    ..., please refrain from placing the call on hold if doing so will trigger recorded music or other sound. From.... Questions may be sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov . Accessibility: LSC complies...

  17. 78 FR 38076 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-25

    ..., please refrain from placing the call on hold if doing so will trigger recorded music or other sound. From... sent by electronic mail to FR_NOTICE_QUESTIONS@lsc.gov . ACCESSIBILITY: LSC complies with the...

  18. 76 FR 6134 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    .... Robert E. Feldman, Executive Secretary of the Corporation, at 202-898-7043. Dated: January 31, 2011. Federal Deposit Insurance Corporation. Robert E. Feldman, Executive Secretary. [FR Doc. 2011-2445 Filed...

  19. 75 FR 3895 - Yale University, et al.;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-25

    ..., Quanta 3D Dual-Beam Focused Ion-Beam Tool. Manufacturer: FEI Company, Czech Republic. Intended Use: See..., Quanta 200 FEG. Manufacturer: FEI Company, Czech Republic. Intended Use: See notice at 74 FR...

  20. 76 FR 51847 - Air Cargo Screening

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-18

    ... apply to international inbound cargo. \\2\\ 74 FR 47672. The IFR provides detailed information on TSA's..., Express Delivery and Logistics Association, International Air Transport Association, Meridian One... for international inbound cargo. TSA Response: TSA is working closely with its foreign...

  1. 78 FR 44247 - Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... published previously a final rule establishing energy conservation standards for ice-cream freezers, self... measuring ice maker energy use. Timetable: Action Date FR Cite NPRM 07/00/13 Final Action...

  2. 75 FR 52554 - Office of the Secretary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ...://www.reginfo.gov/public/do/PRAMain or by contacting Linda Watts Thomas on 202-693-4223 (this is not a... Register on January 22, 2010, (75 FR 3759). Dated: August 20, 2010. Linda Watts Thomas, Acting...

  3. 78 FR 70207 - Airworthiness Directives; Airbus Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-25

    ... FR 46 at junction radius level. This frame, that was previously repaired due to a crack finding in... Friday, except Federal holidays. The AD docket contains this AD, the MCAI, the regulatory evaluation,...

  4. 77 FR 39677 - Performance Review Board Membership

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... [Federal Register Volume 77, Number 129 (Thursday, July 5, 2012)] [Notices] [Page 39677] [FR Doc No: 2012-16331] ARCHITECTURAL AND TRANSPORTATION BARRIERS COMPLIANCE BOARD Performance Review Board Membership AGENCY: Architectural and Transportation Barriers Compliance Board. ACTION: Notice....

  5. 75 FR 68789 - Sunshine Act Notices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-09

    ... (Ninth Floor) Status: This meeting will be open to the public. Items To Be Discussed: Correction and... Werth, Secretary and Clerk of the Commission. [FR Doc. 2010-28223 Filed 11-8-10; 8:45 am] BILLING...

  6. 78 FR 38236 - Proposed Establishment, Modification and Cancellation of Air Traffic Service (ATS) Routes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ...: is a newly established route to become effective August 22, 2013 (78 FR 29615, May 21, 2013... August 22, 2013 (78 FR 29615, May 21, 2013), extending between the LOUIE, MD, fix and the Lancaster,...

  7. 76 FR 20006 - Wind Turbine Guidelines Advisory Committee; Teleconference Line Available for Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... a notice of establishment of the Committee in the Federal Register (72 FR 11373). The Committee's... FR 9590). Meeting Location Information Please note that the in-person meeting location is full...

  8. 76 FR 38677 - Wind Turbine Guidelines Advisory Committee; Announcement of Public Meeting and Webcast

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-01

    ... of the Committee in the Federal Register (72 FR 11373). The Committee's purpose is to provide advice..., 2011, with a comment-period ending date of May 19, 2011 (76 FR 9590). The purpose of the...

  9. 76 FR 54481 - Wind Turbine Guidelines Advisory Committee; Announcement of Public Meeting and Webcast

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... of the Committee in the Federal Register (72 FR 11373). The Committee's purpose is to provide advice..., 2011, with a comment-period ending date of May 19, 2011 (76 FR 9590). The purpose of the...

  10. 78 FR 22773 - Revisions to Reliability Standard for Transmission Vegetation Management; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... Federal Register of Thursday, March 28, 2013 (78 FR 18817). The regulations established procedures with... of the Final Rule. In FR Doc. 2013-07113 appearing on page 18817 in the Federal Register of...

  11. 78 FR 2646 - Proposed Modification of Class B Airspace; Las Vegas, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-14

    ... FR 65332) closed on December 26, 2012, is reopened until February 13, 2013. ADDRESSES: Send comments... of Class B Airspace; Las Vegas, NV'' (77 FR 65332). The FAA requested that comments on that...

  12. 76 FR 2712 - Ocwen Loan Servicing, LLC, Including Workers Whose Wages Were Reported Under Barclays Capital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... Register on December 8, 2010 (75 FR 76488). The notice as amended on December 17, 2010 to include workers... January 3, 2011 (76 FR 178). At the request of the company, the Department reviewed the certification...

  13. 77 FR 55186 - Executive-Led Indonesia Vietnam Infrastructure Business Development Mission Statement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ...-Led Indonesia Vietnam Infrastructure Business Development Mission Statement, 77 FR, No. 131, July 9... Statement, 77 FR, No. 131, July 9, 2012, is amended to read as follows: Timeframe for Recruitment...

  14. 78 FR 54454 - Open Meeting of the Information Security and Privacy Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ... include the following items: --Cybersecurity Executive Order 13636, Improving Critical Infrastructure Cybersecurity (78 FR 11737, February 19, 2013); Development of New Cybersecurity Framework; Request for Information (RFI)--Developing a Framework to Improve Critical Infrastructure Cybersecurity (78 FR...

  15. 78 FR 25254 - Announcing an Open Meeting of the Information Security and Privacy Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... following items: --Cybersecurity Executive Order 13636, Improving Critical Infrastructure Cybersecurity (78 FR 11737, February 19, 2013); Development of New Cybersecurity Framework; Request for Information (RFI)--Developing a Framework to Improve Critical Infrastructure Cybersecurity (78 FR 13024,...

  16. 78 FR 72063 - Open Meeting of the Information Security and Privacy Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... include the following items: --Cybersecurity Executive Order 13636, Improving Critical Infrastructure Cybersecurity (78 FR 11737, February 19, 2013); Development of New Cybersecurity Framework; Request for Information (RFI)--Developing a Framework to Improve Critical Infrastructure Cybersecurity (78 FR...

  17. 76 FR 21266 - Proposed Amendment of Class E Airspace; Cocoa, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... continues to read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565,...

  18. 76 FR 25565 - Defense Federal Acquisition Regulations Supplement; Guidance on Personal Services (DFARS Case...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... their own procedures. DoD published an interim rule at 75 FR 54524 on September 8, 2010, to implement... published at 75 FR 54524 on September 8, 2010, with the following changes: 0 1. The authority citation...

  19. 77 FR 32704 - Self-Regulatory Organizations; Municipal Securities Rulemaking Board; Order Granting Approval of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ..., 2012), 77 FR 22367 (``Notice''). \\5\\ See letter to Elizabeth M. Murphy, Secretary, Commission, from.... 66625 (March 20, 2012), 77 FR 17548 (March 26, 2012) (SR-MSRB-2012-04). The MSRB noted that,...

  20. 78 FR 78451 - Self-Regulatory Organizations; Municipal Securities Rulemaking Board; Notice of Designation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ... (June 24, 2013), 78 FR 39048. \\4\\ See letters to Elizabeth M. Murphy, Secretary, Commission, from Tamara.... 70531 (September 26, 2013), 78 FR 60985 (October 2, 2013) (``Order Instituting Proceedings'')....

  1. 75 FR 8389 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, OMB No...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... title has changed since publication of the 60-day Federal Register Notice at 74 FR 48090, Sept. 21, 2009... changed since publication of the 60-day Federal Register Notice at 74 FR 48090, Sept. 21, 2009....

  2. 75 FR 8385 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, OMB No...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... changed since publication of the 60-day Federal Register Notice at 74 FR 48091, Sept. 21, 2009. Type of... publication of the 60-day Federal Register Notice at 74 FR 48091, Sept. 21, 2009. Form Titles and...

  3. 76 FR 71465 - Defense Federal Acquisition Regulations Supplement; Notification Requirements for Awards of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... DoD published an interim rule at 75 FR 40716 on July 13, 2010, to implement section 814 of the... final the interim rule published at 75 FR 40716 on July 13, 2010, with the following changes: PART...

  4. 78 FR 33977 - Approval and Promulgation of Air Quality Implementation Plans; Delaware, District of Columbia...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ...?collectionCode=CFR . C. Maryland Section 52.1072 Conditional approval. On April 17, 2003, (68 FR 19106), EPA... section is being removed because on April 15, 2004 (69 FR 19937), 40 CFR 52.1072 was stayed...

  5. 77 FR 43612 - Certain Lighting Control Devices Including Dimmer Switches and Parts Thereof (IV); Decision To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... Coopersburg, Pennsylvania. 76 FR 35015-16. The complaint alleges violations of section 337 of the Tariff Act... disapprove the Commission's action. See Presidential Memorandum of July 21, 2005, 70 FR 43251 (July 26,...

  6. 77 FR 69499 - Certain LED Photographic Lighting Devices and Components Thereof; Notice of the Commission's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... Litepanels, Ltd. (collectively, ``Litepanels''). 76 FR 55416 (Sept. 7, 2011). The complaint alleged... disapprove the Commission's action. See Presidential Memorandum of July 21, 2005, 70 FR 43251 (July 26,...

  7. 77 FR 64827 - Certain Lighting Control Devices Including Dimmer Switches and Parts Thereof (IV); Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... filed by Lutron Electronics Co., Inc. (``Lutron'') of Coopersburg, Pennsylvania. 76 FR 35015-16. The... bonding from the parties and interested non-parties. 77 FR 43612-14 (July 25, 2012). On August 2 and...

  8. 77 FR 30888 - Heating, Cooling, and Lighting Standards for Bureau-Funded Dormitory Facilities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... 30888-30891] [FR Doc No: 2012-12678] DEPARTMENT OF THE INTERIOR Bureau of Indian Affairs 25 CFR Part 36... method for administering grants to tribally controlled schools. 70 FR 22178. [[Page 30889

  9. 76 FR 66995 - David T. Koon, M.D.; Revocation of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ...); Sheran Arden Yeates, 71 FR 39130, 39131 (2006); Dominick A. Ricci, 58 FR 51104, 51105 (1993); Bobby Watts... registration (when required), the Agency has revoked the practitioner's registration. James Stephen...

  10. 77 FR 38289 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ..., without extension, Capital Assessments and Stress Testing information collection (FR Y- 14A/Q/M). The... Stress Testing information collection (FR Y-14A/Q/M). In recognition of the complexities of the...

  11. 75 FR 5631 - Wolf Creek Nuclear Operating Corporation, Wolf Creek Generating Station; Environmental Assessment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-03

    ... Federal Register notice dated March 27, 2009 (74 FR 13967). There will be no change to radioactive... no significant impact [Part 73, Power Reactor Security Requirements, 74 FR 13926, 13967 (March...

  12. 77 FR 61429 - Agency Information Collection Activities: Announcement of the Office of Management and Budget...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    .... OSHA-2012-0005. Coke Oven Emissions (29 CFR 1910.1029)........ 08/22/2011, 76 FR 52350, Docket 1218... FR 61752, Docket 1218-0061 03/31/2015 No. OSHA-2011-0194. Electrical Standards for Construction...

  13. 75 FR 47604 - Draft Guidance for Industry and Food and Drug Administration Staff; Medical Devices; Neurological...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... July 28, 2010 (75 FR 44267). The document reopened the comment period for a notice of availability of..., Silver Spring, MD 20993, 301-796-9148. SUPPLEMENTARY INFORMATION: In FR Doc. 2010-18406, appearing...

  14. 78 FR 16817 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; 2013 Commercial Accountability...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... implemented the final rule (65 FR 16336, March 28, 2000) that divided the Florida west coast subzone of the... southern Florida west coast subzone (78 FR 15642, March 12, 2013). Under 50 CFR 622.43(a), NMFS is...

  15. 77 FR 35747 - Highway Safety Programs; Conforming Products List of Evidential Breath Alcohol Measurement Devices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ... Evidential Breath Alcohol Measurement Devices AGENCY: National Highway Traffic Safety Administration... Specifications for Evidential Breath Alcohol Measurement Devices dated, September 17, 1993 (58 FR 48705). DATES... Alcohol (38 FR 30459). A Qualified Products List of Evidential Breath Measurement Devices comprised...

  16. 77 FR 30559 - Entergy Nuclear Operations, Inc.; Establishment of Atomic Safety and Licensing Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ... delegation by the Commission dated December 29, 1972, published in the Federal Register, 37 FR 28,710 (1972... accordance with the NRC E-filing rule, which the NRC promulgated in August 2007 (72 FR 49,139). Issued...

  17. 78 FR 45935 - Domestic Nuclear Detection Office; Announcement of Requirements and Registration for the National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-30

    ... information about the Rad/Nuc Challenge, visit http://www.radnucchallenge.org . Correction Correct FR Doc. 2013-10928 as follows: 1. In the Federal Register of May 8, 2013, in FR Doc. 2013-10928, on page...

  18. 78 FR 79362 - Proposed Flood Elevation Determinations for Nicollet County, Minnesota, and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... Incorporated Areas. DATES: The proposed rule published October 6, 2011, at 76 FR 62006, is withdrawn as of... INFORMATION: On October 6, 2011, FEMA published a proposed rulemaking at 76 FR 62006, proposing...

  19. 78 FR 79298 - Securities Exempted; Distribution of Shares by Registered Open-End Management Investment Company...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... Business Investment Companies, 23 FR 10484 (Dec. 30, 1958). \\2\\ Amendments to the Offering Exemption Under Regulation E of the Securities Act of 1933, 49 FR 35342 (Sept. 7, 1984). As part of Regulation E, rule...

  20. 76 FR 15224 - Reducing Regulatory Burden; Retrospective Review Under E.O. 13563

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ... Regulatory Burden; Retrospective Review Under E.O. 13563 AGENCY: Office of the Secretary, Labor. ACTION...: E.O. 13653, 76 FR 3821, Jan. 21, 2011; E.O. 12866, 58 FR 51735, Oct. 4, 1993. Dated: March 15,...

  1. 76 FR 18104 - Reducing Regulatory Burden; Retrospective Review Under E.O. 13563

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... Regulatory Burden; Retrospective Review Under E.O. 13563 AGENCY: Office of the Secretary, Labor. ACTION...: E.O. 13653, 76 FR 3821, Jan. 21, 2011; E.O. 12866, 58 FR 51735, Oct. 4, 1993. William E....

  2. 76 FR 43347 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cooperative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ... pursuant to Section 6(b) of the Act on February 26, 2009 (74 FR 8813). The last notification was filed with...) of the Act on June 4, 2010 (75 FR 31816). Patricia A. Brink, Director of Civil Enforcement,...

  3. 75 FR 4422 - Notice Pursuant to The National Cooperative Research and Production Act of 1993-Cooperative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... Register pursuant to Section 6(b) of the Act on February 25, 2008 (73 FR 10064). The last notification was... December 17, 2009 (74 FR 66995). Patricia A. Brink, Deputy Director of Operations, Antitrust...

  4. 76 FR 32886 - Control of Emissions From New Highway Vehicles and Engines; Guidance on EPA's Certification...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-07

    ... protection and infrastructure requirements, and requirements regarding unregulated pollutants. \\7\\ See 75 FR... final guidance. \\9\\ See 75 FR 39251 (July 8, 2010). Public comments received in response to the...

  5. 75 FR 66792 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Cooperative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... February 25, 2008 (73 FR 10064). The last notification was filed with the Department on December 10, 2009. A notice was published in the Federal Register on January 27, 2010 (75 FR 4422). Patricia A....

  6. 77 FR 46960 - Approval and Promulgation of Air Quality Implementation Plans; Wisconsin; Forest County...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-07

    ... information on the Class I Area redesignation, see 73 FR 23086, April 29, 2008, and 77 FR 20575, April 5, 2012..., Particulate matter, Reporting and recordkeeping requirements, Sulfur oxides, Volatile organic compounds....

  7. 76 FR 80344 - Privacy Act of 1974: Systems of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ...] [FR Doc No: 2011-32942] DEPARTMENT OF COMMERCE National Telecommunications and Information...: National Telecommunications and Information Administration, U.S. Department of Commerce. ACTION: Notice. [[Page 80345

  8. Gravitomagnetic gyroscope precession in Palatini f(R) gravity

    SciTech Connect

    Ruggiero, Matteo Luca

    2009-04-15

    We study gravitomagnetic effects in the Palatini formalism of f(R) gravity. On using the Kerr-de Sitter metric, which is a solution of f(R) field equations, we calculate the impact of f(R) gravity on the gravitomagnetic precession of an orbiting gyroscope. We show that, even though an f(R) contribution is present in principle, its magnitude is negligibly small and far to be detectable in the present (like GP-B) and foreseeable space missions or observational tests around the Earth.

  9. 75 FR 27845 - Tennessee Disaster Number TN-00038

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-18

    ..., Hardin, Jackson, Lauderdale, Lawrence, Lewis, Macon, Robertson, Smith, Stewart, Trousdale, Wayne, Wilson... Assistance Numbers 59002 and 59008) James E. Rivera, Associate Administrator for Disaster Assistance. [FR...

  10. 76 FR 50714 - Federal Acquisition Regulation; Documenting Contractor Performance; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ... Federal Acquisition Regulation; Documenting Contractor Performance; Correction AGENCY: Department of... Performance. DATES: The comment period for the proposed rule published June, 28, 2011, at 76 FR 37704,...

  11. 75 FR 10254 - Environmental Impact Statements; Notice of Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    .... 20100050, Draft EIS, BLM, CA, Stirling Energy Systems (SES) Solar 2 Project, Construct and Operate..., 2010. Robert W. Hargrove, Director, NEPA Compliance Division, Office of Federal Activities. [FR...

  12. Nuclear Data Sheets for 225Fr

    SciTech Connect

    Baglin, Coral M.

    2005-05-16

    Nuclear structure data pertaining to {sup 225}Fr have been evaluated, and incorporated into the ENSDF data file. This evaluation includes literature available by 16 May 2005 and supersedes the previous publication for {sup 225}Fr (Y.A. Akovali, ''Nuclear Data Sheets 60, 617 (1990)'', literature cutoff date 1 June 1989). Data have been incorporated from the following references: 1987Co19, 1997BuO3 and 2003AuO3.

  13. 75 FR 30385 - Foreign-Trade Zone 64-Jacksonville, FL; Site Renumbering Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ... approved by the FTZ Board (the Board) on December 29, 1980 (Board Order 170, 46 FR 1330, 01/06/81) and expanded on September 20, 1985 (Board Order 312, 50 FR 40209, 10/02/85), on December 24, 1986 (Board Order 337, 52 FR 1214, 01/12/87), on October 29, 1991 (Board Order 540, 56 FR 56627, 11/06/91), and...

  14. Ion transport of Fr nuclear reaction products

    SciTech Connect

    Behr, J.A.; Cahn, S.B.; Dutta, S.B.

    1993-04-01

    Experiments planned for fundamental studies of radioactive atoms in magneto-optic traps require efficient deceleration and transport of nuclear reaction products to energies and locations where they can be trapped. The authors have built a low-energy ion transport system for Francium and other alkalis. A thick Au target is held on a W rod at 45{degrees} to the accelerator beam direction. The heavy-ion fusion reaction 115 MeV {sup 18}O + {sup 197}Au produces {sup 211,210,209}Fr recoil products which are stopped in the target. The target is heated to close to the melting point of Au to allow the Fr to diffuse to the surface, where it is ionized due to Au`s high work function, and is directly extracted by an electrode at 90{degrees} to the accelerator beam direction. The Fr is transported by electrostatic optics {approximately}1 m to a catcher viewed by an {alpha} detector: {ge}15% of the Fr produced in the target reaches the catcher. 2{times}10{sup 5} Fr/sec have been produced at the catcher, yielding at equilibrium a sample of 3x10{sup 7}Fr nuclei. This scheme physically decouples the target diffusion from the surface neutralization process, which can occur at a lower temperature more compatible with the neutral-atom trap.

  15. 78 FR 63015 - Exhaust Emissions Standards for New Aircraft Gas Turbine Engines and Identification Plate for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... kilonewtons (kN) (76 FR 45012). The EPA also proposed adopting the gas turbine engine test procedures of the... 18, 2012 (77 FR 36342), and was effective July 18, 2012. On December 31, 2012, the FAA published a final rule with a request for comments (77 FR 76842) adopting the EPA's new emissions standards in...

  16. 78 FR 63017 - Exhaust Emissions Standards for New Aircraft Gas Turbine Engines and Identification Plate for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... engines with rated thrusts greater than 26.7 kilonewtons (kN) (76 FR 45012). The EPA also proposed...). The final rule adopting these proposals was published on June 18, 2012 (77 FR 36342), and was... (77 FR 76842) adopting the EPA's new emissions standards in part 34. Although the EPA's NPRM...

  17. 78 FR 33966 - Establishment of Class E Airspace; Pine Island, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... Pine Island, FL (78 FR 14477). Interested parties were invited to participate in this rulemaking effort... Executive Order 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR...: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp., p....

  18. 77 FR 58765 - Airworthiness Directives; Fokker Services B.V. Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... NPRM was published in the Federal Register on June 12, 2012 (77 FR 34872). That NPRM proposed to... in developing this AD. We received no comments on the NPRM (77 FR 34872, June 12, 2012) or on the... NPRM (77 FR 34872, June 12, 2012) for correcting the unsafe condition; and Do not add any...

  19. 77 FR 58858 - Agency Information Collection Activity: Subpart B, Plans and Information; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... FR 64432), BSEE is requesting OMB approval of the already approved information collections that were... FR 39419) announcing that we would submit this ICR to OMB for approval. The notice provided the... Register on September 30, 2011 (76 FR 60856). If you wish to comment in response to this notice, you...

  20. 75 FR 62413 - Notice of Proposed Information Collection: Comment Request; Recertification of Family Income and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ... [Federal Register Volume 75, Number 195 (Friday, October 8, 2010)] [Notices] [Page 62413] [FR Doc No: 2010-25355] DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5380-N-37] Notice of... Secretary for Housing. [FR Doc. 2010-25355 Filed 10-7-10; 8:45 am] BILLING CODE 4210-67-P...

  1. 75 FR 18208 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ...: Census of Finance Companies. Agency form number: FR 3033p. OMB control number: 7100-0277. Frequency: One-time. Reporters: Domestic finance companies and mortgage companies. Estimated annual reporting hours: 6... Census of Finance Companies (FR 3033p) and the Quinquennial Finance Company Survey (FR 3033s). The...

  2. 77 FR 29680 - Federal Property Suitable as Facilities To Assist the Homeless

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... [Federal Register Volume 77, Number 97 (Friday, May 18, 2012)] [Notices] [Page 29680] [FR Doc No: 2012-11736] DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5601-N-19] Federal Property... Assistant Secretary for Special Needs. [FR Doc. 2012-11736 Filed 5-17-12; 8:45 am] BILLING CODE 4210-67-P...

  3. 75 FR 22543 - Airworthiness Directives; Aircraft Industries a.s. Model L 23 Super Blanik Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... proposed AD. Discussion On March 29, 2010, we issued AD 2010-08-01, Amendment 39-16256 (75 FR 17295; April... rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will... amends Sec. 39.13 by removing Amendment 39-16256 (75 FR 17295; April 6, 2010), and adding the...

  4. 77 FR 58469 - Asian Longhorned Beetle; Quarantined Areas in Massachusetts, Ohio, and New York

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-21

    ... interim rule published at 77 FR 31720-31722 on May 30, 2012. FOR FURTHER INFORMATION CONTACT: Ms. Claudia... rule \\1\\ effective and published on May 30, 2012, in the Federal Register (77 FR 31720-31722, Docket No..., the interim rule that amended 7 CFR part 301 and that was published at 77 FR 31720-31722 on May...

  5. 77 FR 3223 - National Emissions Standards for Hazardous Air Pollutants: Mineral Wool Production and Wool...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-23

    ...-3224] [FR Doc No: 2012-1222] ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 63 [EPA-HQ-OAR-2010-1042; FRL... rule (76 FR 78872). The comment period for the mineral wool production proposed rule was not extended..., Assistant Administrator. [FR Doc. 2012-1222 Filed 1-20-12; 8:45 am] BILLING CODE 6560-50-P...

  6. 76 FR 37272 - Approval and Promulgation of Air Quality Implementation Plans; Illinois; Royal Fiberglass Pools...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ... Illinois SIP on February 21, 1980 (45 FR 11472). The rule states that ``no person shall cause or allow the... FR 51735, October 4, 1993); Does not impose an information collection burden under the provisions of... Federalism implications as specified in Executive Order 13132 (64 FR 43255, August 10, 1999); Is not...

  7. 75 FR 2582 - Proposed Modification of the Atlanta, GA, Class B Airspace Area; Public Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ..., in Covington, GA, as published in the Federal Register on Friday, December 4, 2009 (74 FR 63818), FR... Federal Aviation Administration Proposed Modification of the Atlanta, GA, Class B Airspace Area; Public... Friday, December 4, 2009, concerning a proposal to revise Class B airspace at Atlanta, GA, (74 FR...

  8. 76 FR 68734 - Taking and Importing Marine Mammals: Taking Marine Mammals Incidental to Navy Training Exercises...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... mine neutralization training using time-delay firing devices (TDFD) within the above Range Complexes...: 74 FR 28328; JAX: 74 FR 28349; CHPT: 74 FR 28370). The potential effects of mine neutralization... three Range Complexes and mine neutralization training has been included in the specified activity...

  9. 77 FR 3262 - Agency Information Collection Activities; Submission to OMB for Review and Approval; Comment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-23

    ... [Federal Register Volume 77, Number 14 (Monday, January 23, 2012)] [Notices] [Pages 3262-3263] [FR... according to the procedures prescribed in 5 CFR 1320.12. On August 9, 2011 (76 FR 48857), EPA sought... Approved ICR Burdens. John Moses, Director, Collection Strategies Division. [FR Doc. 2012-1181 Filed...

  10. 78 FR 33106 - Certain Automated Media Library Devices; Decision to Modify In Part a Remand Initial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-03

    ... Diego, California (``Overland'') on October 19, 2010, and supplemented on November 9, 2010. 75 FR 71735... on remedy, the public interest and bonding. 77 FR 51573 (August 24, 2012). On September 4, ] 2012... target date for completion of the investigation. 77 FR 65907 (Oct. 31, 2012). Specifically,...

  11. 75 FR 15444 - Agency Information Collection Activities: Submission for OMB Review; Comment Request, OMB No...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ... 60-day Federal Register Notice at 74 FR 59234, Nov. 17, 2009. Abstract: The PSGP is an important tool... 60-day Federal Register Notice at 74 FR 59234, Nov. 17, 2009. Estimated Number of Respondents: 478... Notice at 74 FR 59234, Nov. 17, 2009. Frequency of Response: On Occasion. Estimated Average Hour...

  12. 77 FR 60041 - Heating, Cooling, and Lighting Standards for Bureau-Funded Dormitory Facilities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... final rule (77 FR 30888) for additional background on the Committee. The Committee determined, by..., BIA published the interim final rule (77 FR 30888), under Docket No. BIA-2012-0001, to make the codes... May 24, 2012, at 77 FR 30888, is adopted as final without change. Dated: September 20, 2012. Donald...

  13. 77 FR 58027 - Approval and Promulgation of Implementation Plans; Florida: New Source Review-Prevention of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ...) Program for Particulate Matter Less than 2.5 Micrometers (PM 2.5 ),'' 73 FR 28321 (May 16, 2008... Significant Monitoring Concentration (SMC),'' 75 FR 64864 (October 20, 2010), hereafter referred to as the... Florida's NSR PSD program. See 77 FR 44198. Comments on the proposed rulemaking were due on or...

  14. 76 FR 28455 - Granular Polytetrafluoroethylene Resin From Italy; Scheduling of an Expedited Five-Year Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... determined that the domestic interested party group response to its notice of institution (75 FR 67105... amended, 67 FR 68036 (November 8, 2002). Even where electronic filing of a document is permitted, certain... Filing Procedures, 67 FR 68168, 68173 (November 8, 2002). \\2\\ The Commission has found the...

  15. 76 FR 27663 - Granular Polytetrafluoroethylene Resin From Italy; Scheduling of an Expedited Five-Year Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-12

    ... determined that the domestic interested party group response to its notice of institution (75 FR 67105... amended, 67 FR 68036 (November 8, 2002). Even where electronic filing of a document is permitted, certain... Electronic Filing Procedures, 67 FR 68168, 68173 (November 8, 2002). \\2\\ The Commission has found...

  16. 76 FR 12939 - Granular Polytetrafluoroethylene Resin From Italy: Final Results of Expedited Sunset Review of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-09

    ... amended (``the Act''). See Initiation of Five-Year (``Sunset'') Review, 75 FR 67082 (November 1, 2010... of Five-Year (``Sunset'') Review: Correction, 76 FR 2083 (January 12, 2011) (``Correction Notice... Determination of Circumvention of ] Antidumping Duty Order, 58 FR 26100 (April 30, 1993). The order...

  17. 76 FR 42114 - Granular Polytetrafluoroethylene Resin From Italy: Continuation of Antidumping Duty Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    ... FR 67082 (November 1, 2010). As a result of its review, the ] Department determined that revocation... Expedited Sunset Review of the Antidumping Duty Order, 76 FR 12939 (March 9, 2011). On July 7, 2011, the ITC... Granular Polytetrafluoroethylene Resin From Italy, 76 FR 39896 (July 7, 2011), and USITC Publication...

  18. 78 FR 56734 - Certain Rubber Resins and Processes for Manufacturing Same; Commission Determination To Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... Group'' or ``SI'') on May 21, 2012, as supplemented on June 12, 2012. 77 FR 38083 (June 26, 2012). The...) Limited of Belize City, Belize as respondents. 78 FR 3817 (January 17, 2013). On June 17, 2013, the... approve or disapprove the Commission's action. See Presidential Memorandum of July 21, 2005, 70 FR...

  19. 77 FR 3640 - Withdrawal of Proposed Rule and Closure of Petition for Rulemaking: Organization of Agreement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... licensed device (74 FR 38372; August 3, 2009) is withdrawn on January 25, 2012. The docket for PRM-31-5 is... that would have implemented many of the suggestions in the PRM (74 FR 38372; August 3, 2009). The NRC..., ``Limiting the Quantity of Byproduct Material in a Generally Licensed Device'' (74 FR 38372). This...

  20. 77 FR 37937 - License Renewal Application for Prairie Island Nuclear Generating Plant Independent Spent Fuel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... the license for the ISFSI would be forty (40) years. On February 16, 2011 (76 FR 8872), revisions to... accordance with the NRC E-Filing rule (72 FR 49139; August 28, 2007). The E-Filing process requires...\\ Requestors should note that the filing requirements of the NRC's E-Filing Rule (72 FR 49139; August 28,...

  1. 75 FR 14474 - STP Nuclear Operating Company; Notice of Availability of the Draft Environmental Impact Statement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... report (ER), was published in the Federal Register on October 24, 2007 (72 FR 60394). A notice of... FR 68597). A notice of intent to prepare an environmental impact statement (EIS) and to conduct the scoping process was published in the Federal Register on December 21, 2007 (72 FR 72774). The purpose...

  2. 78 FR 40698 - Takes of Marine Mammals Incidental to Specified Activities; Office of Naval Research Acoustic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ... complete on March 7, 2013. On April 2, 2013, NMFS published a Federal Register notice (78 FR 19652... activity was provided in the proposed IHA (78 FR 19652, April 2, 2013). Comments and Responses A notice of... April 2, 2013 (78 FR 19652). During the 30-day public comment period, we received comments from...

  3. 78 FR 78808 - Proposed Flood Elevation Determinations for Pierce County, Washington, and Incorporated Areas

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ..., and Incorporated Areas. DATES: The proposed rule published December 6, 2007, at 72 FR 68784, corrected April 16, 2012, at 77 FR 22551, is withdrawn effective December 27, 2013. ADDRESSES: You may submit... proposed rulemaking at 72 FR 68784, proposing flood elevation determinations along one or more...

  4. 78 FR 76667 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-18

    ... Act Release No. 69496 (May 2, 2013), 78 FR 26671 (May 7, 2013), (Notice of filing and immediate...), 69 FR 49924 (August 12, 2004) (policy adopted by the Financial Industry Regulatory Authority (``FINRA.... 48840 (November 25, 2003), 68 FR 67711 (December 3, 2003) (SR-ISE-2003-29). \\7\\ The Exchange notes...

  5. 75 FR 42000 - Requirements for Fingerprint-Based Criminal History Records Checks for Individuals Seeking...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... Access to Research and Test Reactors, issued April 30, 2007 (72 FR 25337; May 4, 2007). EA-07-098... for Unescorted Access to the General Atomics Research and Test Reactors, issued August 1, 2007 (72 FR..., 2009 (74 FR 17115). Regulatory Analysis X ML101670084 X Regulatory Analysis Appendix...

  6. 76 FR 11523 - Atomic Safety and Licensing Board; AREVA Enrichment Services, LLC (Eagle Rock Enrichment Facility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ..., ID, 76 FR 9054 (Feb. 16, 2011). In accord with Atomic Energy Act (AEA) section 274l, 42 U.S.C. Sec... Rock Enrichment Facility), 74 FR 38,052, 38,055 (Jul. 30, 2009) (CLI-09- 15, 70 NRC 1, 10-11 (2009... of Enrichment Facility Licensing Proceeding), 75 FR 63,213 (Oct. 14, 2010), which was the subject...

  7. 78 FR 37325 - License Renewal of Nuclear Power Plants; Generic Environmental Impact Statement and Standard...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-20

    ... applicants and the NRC staff. The NRC published the draft Revision 1 to the GEIS on July 31, 2009 (74 FR... comment period to January 12, 2010 (74 FR 51522; October 7, 2009). The intent of the GEIS is to determine... concerned or pertained to the proposed rule (74 FR 38117 published July 31, 2009) and to the draft...

  8. 77 FR 17033 - Taking and Importing Marine Mammals: Taking Marine Mammals Incidental to Navy's Training...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... GOMEX Range Complex were published on February 17, 2011 (76 FR 9250), and remain in effect through... Register notice and 50 CFR part 218 subpart D. On February 1, 2012, NMFS published a final rule (77 FR 4917... issued on February 17, 2011 (76 FR 9250). The application requested authorization, for a period of...

  9. 77 FR 4995 - Initiation of Five-Year (“Sunset”) Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... Countervailing Duty Orders, 63 FR 13516 (March 20, 1998) and 70 FR 62061 (October 28, 2005). Guidance on... Antidumping and Countervailing Duty Orders: Policy Bulletin, 63 FR 18871 (April 16, 1998). Initiation of... 731-TA-739......... Japan......... Clad Steel Plate (3rd Review)..... David Goldberger (202)...

  10. 76 FR 77230 - Agency Information Collection Activities; Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ... Amended: Advance Notice of Proposed Rulemaking; Request for Public Comment, 76 FR 41148 (Jul. 13, 2011... Proposed Rulemaking: Request for Comment, 76 FR 13550 (Mar. 14, 2011); and Federal Trade Commission: Rules... Rulemaking; Request for Public Comment, 76 FR 68690 (Nov. 7, 2011). The Commission also announced that...

  11. 78 FR 79300 - Cardiovascular Devices; Reclassification of Intra-Aortic Balloon and Control Systems for Acute...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... proposed order in the Federal Register of June 19, 2013 (78 FR 36702) (the 2013 proposed order). FDA... adequate scientific evidence. FDA published the 2013 proposed order on June 19, 2013 (78 FR 36702). FDA... devices were classified in 1980, the 30-month period has expired (45 FR 7966; February 5, 1980)....

  12. 78 FR 79295 - Airworthiness Directives; CFM International S.A. Turbofan Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... FR 34605). The NPRM proposed to require an independent inspection to verify re-installation of the... assemblies using the SBs referenced in the NPRM (78 FR 34605, June 10, 2013) along with other acceptable... that we harmonize differences between the NPRM (78 FR 34605, June 10, 2013) and EASA AD...

  13. 78 FR 79449 - Information Collection Being Reviewed by the Federal Communications Commission Under Delegated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ...-Speech Services for Individuals with Hearing and Speech Disabilities, FCC 04-137, published at 69 FR 53346, September 1, 2004, and at 69 FR 53382, September 1, 2004. In the Report and Order, the Commission... Service, FCC 06-182, published at 72 FR 6960, February 14, 2007. The ruling applied several of the...

  14. 78 FR 79461 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... and restaurants. In the Federal Register of November 1, 2013 (78 FR 65663), FDA published a 60-day... referenced our Federal Register notice published on November 8, 2013 (78 FR 67169) (``the November 8, 2013... provided in the nutrition labeling of food. In the Federal Register of July 11, 2003 (68 FR 41434),...

  15. 78 FR 79403 - Takes of Marine Mammals Incidental to Specified Activities; Taking Marine Mammals Incidental to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... of California Santa Cruz published in the Federal Register on October 30, 2013 (78 FR 64918... time. The Federal Register notice that NMFS incorrectly published on December 23, 2013 (78 FR 77433... Proposed IHA notice of December 23, 2013 (78 FR 77433), as the public was already afforded an...

  16. 78 FR 79340 - Approval and Promulgation of Air Quality Implementation Plans; Texas; Stage II Vapor Recovery...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... worse. The EPA approved these rules on April 15, 1994 (59 FR 17940). The four areas where Stage II is... Refueling Vapor Recovery and Stage II Waiver, published on July 15, 2011 (76 FR 41731). Each year, non-ORVR... to and will soon surpass the emission reductions achieved by Stage II alone (see 77 FR 28772). In...

  17. 78 FR 79636 - Restructuring of Regulations on the Importation of Plants for Planting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... 79636-79637] [FR Doc No: 2013-31146] DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection.... DATES: The comment period for the proposed rule published April 25, 2013 (78 FR 24634) is reopened. We..., 2013, we published in the Federal Register (78 FR 24634-24663, Docket No. APHIS-2008-0011) a...

  18. 78 FR 80381 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-72; Small Entity Compliance Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ...] [Pages 80381-80382] [FR Doc No: 2013-31152] DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION... rule adopts, without change, an interim rule which was published in the Federal Register at 78 FR 37686...-wide Policy. [FR Doc. 2013-31152 Filed 12-30-13; 8:45 am] BILLING CODE 6820-EP-P...

  19. 78 FR 79620 - Defense Federal Acquisition Regulation Supplement; Trade Agreements Thresholds (DFARS Case 2013...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ...] [Pages 79620-79621] [FR Doc No: 2013-30792] DEPARTMENT OF DEFENSE Defense Acquisitions Regulations System... FR 76700, December 18, 2013): Supply contract Construction Trade agreement (equal to or contract... removing ``$202,000'' and adding ``$204,000'' in its place. [FR Doc. 2013-30792 Filed 12-30-13; 8:45...

  20. 78 FR 80376 - Federal Acquisition Regulation; Prioritizing Sources of Supplies and Services for Use by the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ...] [Pages 80376-80379] [FR Doc No: 2013-31149] DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION... Federal Register at 76 FR 34634 on June 14, 2011, to amend the Federal Acquisition Regulation (FAR) to... published in the Federal Register at 77 FR 54872 on September 6, 2012. Six respondents submitted comments...

  1. 78 FR 80382 - Federal Acquisition Regulation; Terms of Service and Open-Ended Indemnification and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ...] [Pages 80382-80384] [FR Doc No: 2013-31150] DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION... 78 FR 37686 on June 21, 2013, to implement a recent DOJ OLC opinion, entitled ``Memorandum for... 12, 13, 32, 43, and 52, which was published in the Federal Register at 78 FR 37686 on June 21,...

  2. 78 FR 79567 - Food Distribution Program on Indian Reservations: Income Deductions and Resource Eligibility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ...] [Page 79567] [FR Doc No: 2013-31351] DEPARTMENT OF AGRICULTURE Food and Nutrition Service 7 CFR Part 253... ICR associated with the final rule published in the Federal Register on August 27, 2013, at 78 FR... Nutrition Service. [FR Doc. 2013-31351 Filed 12-30-13; 8:45 am] BILLING CODE 3410-30-P...

  3. 78 FR 79701 - Tentative Determination Regarding Partially Hydrogenated Oils; Request for Comments and for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Notices] [Page 79701] [FR... November 8, 2013 (78 FR 67169). In the notice, we requested comments on our tentative determination that... (78 FR 67169), FDA published a notice announcing our tentative determination that PHOs, which are...

  4. 78 FR 79721 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... 79721-79723] [FR Doc No: 2013-31229] SECURITIES AND EXCHANGE COMMISSION [Release No. 34-71182; File No... Exchange Act Release No. 63955 (February 24, 2011), 76 FR 11533 (March 2, 2011) (SR-ISE-2010-73). For... Release No. 54389 (August 31, 2006), 71 FR 52829 (September 7, 2006) (Original QCT Exemption)....

  5. 78 FR 79662 - Approval of Subzone Status; VF Jeanswear; Hackleburg, Alabama

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Notices] [Page 79662] [FR... (78 FR 59469, 9/27/2013). The FTZ staff examiner reviewed the application and determined that it meets... activation limit. Dated: December 19, 2013. Andrew McGilvray, Executive Secretary. [FR Doc. 2013-31352...

  6. 78 FR 79652 - Taxation of U.S. Persons That Are Shareholders of Section 1291 Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ...] [FR Doc No: 2013-30844] DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR Part 1 [REG-113350...). DATES: The proposed rule published in the Federal Register on April 1, 1992 (57 FR 11024) is withdrawn... regulations (INTL-656-87, 1992-18 IRB 23, 57 FR 11024), including Sec. 1.1291-1 that provided guidance on...

  7. 78 FR 40523 - Order Exempting Market Makers Participating in NASDAQ Stock Market LLC's Market Quality Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... Exchange Act Release No. 68515 (Dec. 21, 2012), 77 FR 77141 (Dec. 31, 2012) (``Notice''). On February 7.... 68925 (Feb. 14, 2013), 78 FR 12116 (Feb. 21, 2013). The Approval Order grants approval of the proposed...).\\6\\ \\5\\ 15 U.S.C. 78k(d)(1). \\6\\ See, e.g., Exchange Act Release Nos. 6726 (Feb. 8, 1962), 27 FR...

  8. 75 FR 73967 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ..., 2000 edition of the Federal Register and codified in 40 CFR part 62, subpart I. (65 FR 20090). However... Order Reviews A. General Requirements Under Executive Order 12866 (58 FR 51735, October 4, 1993), this... Concerning Regulations That Significantly Affect Energy Supply, Distribution, or Use'' (66 FR 28355, May...

  9. 77 FR 43301 - Medicaid Program; Disproportionate Share Hospital Allotments and Institutions for Mental Diseases...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... Disproportionate Share Hospital Limits'' notice published in the January 3, 2011 Federal Register (76 FR 148). II... in the ``Background'' section of the January 3, 2011 Federal Register (76 FR 148) notice, the... (75 FR 21314). The final FY 2011 DSH allotments being published in this notice are approximately...

  10. 76 FR 148 - Medicaid Program; Final FY 2009 and Preliminary FY 2011 Disproportionate Share Hospital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ... limits determined. The notice published in the Federal Register on December 19, 2008 (73 FR 77704... correction notice published in the Federal Register on January 26, 2009 (74 FR 4439) provided a correction to.... Finally, the notice published in the Federal Register on April 23, 2010 (75 FR 21314), included...

  11. 77 FR 217 - Medicare and Medicaid Programs: Hospital Outpatient Prospective Payment; Ambulatory Surgical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-04

    ..., Hospital Value-Based Purchasing (VBP) Program Issues. SUPPLEMENTARY INFORMATION: I. Background In FR Doc. 2011-28612 of November 30, 2011 (76 FR 74122), (hereinafter referred to as the CY 2012 OPPS/ASC final... they had been included in the CY 2012 OPPS/ASC final rule with comment period (76 FR 74122)...

  12. 75 FR 30756 - Medicare Program; Supplemental Proposed Changes to the Hospital Inpatient Prospective Payment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ..., 2010. DATES: The comment period for the proposed rule FR Doc. No. 2010-12567, published elsewhere in...) 786-4487. SUPPLEMENTARY INFORMATION: I. Background In FR Doc. 2010-12567 filed May 21, 2010, there are... the FY 2011 IPPS/LTCH PPS proposed rule (75 FR 23852).'' Therefore, in section III. of this...

  13. 75 FR 78916 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... 10, 2004 edition of the Federal Register and codified in 40 CFR Part 62, subpart VV. (69 FR 54756... (58 FR 51735, October 4, 1993), this action is not a ``significant regulatory action'' and therefore... Energy Supply, Distribution, or Use'' (66 FR 28355, May 22, 2001). This action merely approves State...

  14. 76 FR 35959 - Capital Adequacy Guidelines; Small Bank Holding Company Policy Statement: Treatment of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... Board issued an interim final rule (CPP interim rule) (74 FR 26077) to allow bank holding companies that... Board published a final rule on the capital treatment of the Senior Perpetual Preferred Stock. See 74 FR.... See 74 FR 26077, 26079 (June 1, 2009). The Board received two comments on the CPP interim rule....

  15. 77 FR 25405 - Modification to Content Published by Import Administration in the Federal Register

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-30

    ... FR and identify the content that will remain in the FR notices and the content that will be included... required to publish certain notices in the Federal Register (FR). Following review of the requirements of the Act and our regulations, we have identified ways to shorten the length of many of our...

  16. 78 FR 44124 - Agency Information Collection Activities: Proposed Collection; Comment Request; Format and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... 0910-0340)--Extension In the Federal Register of March 17, 1999 (64 FR 13254) (the 1999 labeling final.... On June 20, 2000 (65 FR 38191), we published a Federal Register final rule that required all OTC drug... May 16, 2005, or sooner (65 FR 38191 at 38193). Currently marketed OTC drug products are...

  17. 77 FR 16234 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... (71 FR 3922), and was effective on June 30, 2006, amended FDA's regulations governing the format and... final rule (71 FR 3964-3967) (currently approved under OMB control number 0910-0572) estimated the.... In the Federal Register of December 19, 2011 (76 FR 78668), FDA published a 60-day notice...

  18. 75 FR 31448 - Agency Information Collection Activities; Proposed Collection; Comment Request; Format and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-03

    ...)--Reinstatement In the Federal Register of March 17, 1999 (64 FR 13254), we amended our ] regulations governing... are already required to be in compliance with these labeling regulations. On June 20, 2000 (65 FR... sooner (65 FR 38191 at 38193). Sunscreen products do not have to comply with the regulations until...

  19. 75 FR 49495 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ... Federal Register of March 17, 1999 (64 FR 13254) (the 1999 labeling final rule), we amended our... published in the Federal Register of April 5, 2002 (67 FR 16304), the agency delayed the compliance dates... Sec. 201.66(d)(10) (67 FR 16304 at 16306). The agency issued this delay in order to develop...

  20. 78 FR 12760 - Guidance for Industry on Labeling for Human Prescription Drug and Biological Products...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... January 24, 2006 (71 FR 3998), FDA announced the availability of final guidances on the content and format... of March 23, 2010 (75 FR 13766), FDA announced the availability of final guidance on the content and..., 2011 (76 FR 63303), FDA announced the availability of final guidance on the content and format of...

  1. 76 FR 44463 - Children's Products Containing Lead; Technological Feasibility of 100 ppm for Lead Content...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-26

    ... with the limit. On July 27, 2010, we published a notice in the Federal Register (75 FR 43942... received in response to the July 27, 2010 notice, we published a notice in the Federal Register (76 FR 4641... 16, 2011. On March 9, 2011, we published another notice in the Federal Register (76 FR...

  2. 76 FR 63303 - Guidance for Industry on Warnings and Precautions, Contraindications, and Boxed Warning Sections...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... Federal Register of January 24, 2006 (71 FR 3999), FDA issued final guidances on the content and format of...-63304] [FR Doc No: 2011-26297] DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration... October 19, 2009 (74 FR 53507), FDA issued a final guidance on determining established pharmacologic...

  3. 75 FR 26121 - Regulation of Fuels and Fuel Additives: Alternative Affirmative Defense Requirements for Ultra...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... A. Executive Order 12866: Regulatory Planning and Review Under Executive Order (EO) 12866 (58 FR... implications, as specified in Executive Order 13175 (65 FR 67249, November 9, 2000). This rule applies to... Children From Environmental Health Risks and Safety Risks EPA interprets EO 13045 (62 FR 19885, April...

  4. 76 FR 45705 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Diesel-Powered Motor...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... review by the Office of Management and Budget under Executive Order 12866 (58 FR 51735, October 4, 1993... Executive Order 13132 (64 FR 43255, August 10, 1999); Is not an economically significant regulatory action based on health or safety risks subject to Executive Order 13045 (62 FR 19885, April 23, 1997); Is not...

  5. 75 FR 26653 - Approval and Promulgation of Air Quality Implementation Plans; Reformulated Gasoline and Diesel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... 26653-26662] [FR Doc No: 2010-11005] ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 [EPA-R09-OAR-2009..., 2009 (74 FR 33196), EPA proposed to approve revisions to the California regulations for reformulated..., 2009, as revisions to the California SIP. On July 21, 2009 (74 FR 35838), EPA issued a correction...

  6. 76 FR 33660 - Airworthiness Directives; Austro Engine GmbH Model E4 Diesel Piston Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-09

    ... 2010-23-09, Amendment 39-16498 (75 FR 68179, November 5, 2010), for Austro Engine GmbH model E4 diesel...'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will not affect... FR 68179, November 5, 2010), and adding the following new AD: Austro Engine GmbH: Docket No....

  7. 76 FR 54373 - Airworthiness Directives; Austro Engine GmbH Model E4 Diesel Piston Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... certain publication listed in this AD as of November 22, 2010 (75 FR 68179, November 5, 2010). ADDRESSES...-16498 (75 FR 68179, November 5, 2010). That AD applies to the specified products. The NPRM published in the Federal Register on June 9, 2011 (76 FR 33660). That NPRM proposed to continue to require...

  8. 77 FR 72746 - Regulation of Fuels and Fuel Additives: Modifications to Renewable Fuel Standard and Diesel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-06

    ....1451, 80.1453, 80.1454, and 80.1460 published at 77 FR 61281 (October 9, 2012). Because EPA did not...: EPA published a direct final rule on October 9, 2012 (77 FR 61281) to amend provisions in the... the parallel proposed rule also published on October 9, 2012 (77 FR 61313). As stated in the...

  9. 78 FR 63852 - Airworthiness Directives; Hamilton Standard Division and Hamilton Sundstrand Corporation Propellers

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-25

    ... October 25, 2013. The effective date for AD 2013-16-10 (78 FR 49660, August 15, 2013) remains September 19... 2013-16-10, Amendment 39-17548 (78 FR 49660, August 15, 2013), currently requires incorporating... published in the Federal Register. The effective date for AD 2013-16-10 (78 FR 49660, August 15,...

  10. 77 FR 50966 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Attainment Demonstration...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-23

    ... Phase 2 Implementation Rule published on November 29, 2005 (70 FR 71612) specifies that states must... attainment date (November 29, 2005, 70 FR 71612, and 40 CFR 51.908). On April 30, 2004 (69 FR 23951 and 40... control, Nitrogen dioxide, Reporting and recordkeeping requirements, Volatile organic compounds....

  11. Isotope shifts in francium isotopes Fr-213206 and 221Fr

    NASA Astrophysics Data System (ADS)

    Collister, R.; Gwinner, G.; Tandecki, M.; Behr, J. A.; Pearson, M. R.; Zhang, J.; Orozco, L. A.; Aubin, S.; Gomez, E.; FrPNC Collaboration

    2014-11-01

    We present the isotope shifts of the 7 s1 /2 to 7 p1 /2 transition for francium isotopes 206 -213Fr with reference to 221Fr collected from two experimental periods. The shifts are measured on a sample of atoms prepared within a magneto-optical trap by a fast sweep of radio-frequency sidebands applied to a carrier laser. King plot analysis, which includes literature values for 7 s1 /2 to 7 p3 /2 isotope shifts, provides a field shift constant ratio of 1.0520(10) and a difference between the specific mass shift constants of 170(100) GHz amu between the D1 and D2 transitions, of sufficient precision to differentiate between ab initio calculations.

  12. 7 CFR 29.3068 - Tannish-red color (FR).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan....

  13. 7 CFR 29.3068 - Tannish-red color (FR).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan....

  14. 7 CFR 29.3068 - Tannish-red color (FR).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Tannish-red color (FR). 29.3068 Section 29.3068 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... Type 93) § 29.3068 Tannish-red color (FR). A light red shaded toward tan....

  15. 78 FR 62352 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-18

    ... payment card network surveys, supporting statement, and other documentation are available on the Board's.... Reporters: Issuers of debit cards (FR 3064a) and payment card networks (FR 3064b). Estimated annual... networks in connection with the authorization, clearance or settlement of electronic debit transaction...

  16. 77 FR 5570 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ..., 66 FR 15755 (Mar. 20, 2001); Federal Bureau of Investigation (FBI), ``FBI Alcoholism Program,'' JUSTICE/FBI-014, 52 FR 47251 (Dec. 11, 1987); Federal Bureau of Prisons (BOP), ``Employee Assistance..., Washington, DC 20530. FBI: EAP Administrator, Federal Bureau of Investigation, 935 Pennsylvania Ave....

  17. 78 FR 61805 - National Breast Cancer Awareness Month, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-04

    ... [Federal Register Volume 78, Number 193 (Friday, October 4, 2013)] [Presidential Documents] [Pages 61805-61806] [FR Doc No: 2013-24382] #0; #0; #0; Presidential Documents #0; #0; #0;#0;Federal Register... States of America the two hundred and thirty- eighth. (Presidential Sig.) [FR Doc. 2013-24382 Filed...

  18. 77 FR 29674 - National Cancer Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... [Federal Register Volume 77, Number 97 (Friday, May 18, 2012)] [Notices] [Pages 29674-29675] [FR Doc No: 2012-12120] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National... Policy. [FR Doc. 2012-12120 Filed 5-17-12; 8:45 am] BILLING CODE 4140-01-P...

  19. 77 FR 31030 - National Cancer Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... [Federal Register Volume 77, Number 101 (Thursday, May 24, 2012)] [Notices] [Page 31030] [FR Doc No: 2012-12650] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer..., Office of Federal Advisory Committee Policy. [FR Doc. 2012-12650 Filed 5-23-12; 8:45 am] BILLING...

  20. 75 FR 26761 - National Cancer Institute; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... [Federal Register Volume 75, Number 91 (Wednesday, May 12, 2010)] [Notices] [Pages 26761-26762] [FR Doc No: 2010-11313] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National..., Director, Office of Federal Advisory Committee Policy. [FR Doc. 2010-11313 Filed 5-11-10; 8:45 am]...

  1. 78 FR 31570 - National Cancer Institute: Amended Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... [Federal Register Volume 78, Number 101 (Friday, May 24, 2013)] [Notices] [Page 31570] [FR Doc No: 2013-12376] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer... Advisory Committee Policy. [FR Doc. 2013-12376 Filed 5-23-13; 8:45 am] BILLING CODE 4140-01-P...

  2. 75 FR 62297 - National Breast Cancer Awareness Month, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ... [Federal Register Volume 75, Number 195 (Friday, October 8, 2010)] [Presidential Documents] [Pages 62297-62298] [FR Doc No: 2010-25572] #0; #0; #0; Presidential Documents #0; #0; #0;#0;Federal Register... of America the two hundred and thirty-fifth. (Presidential Sig.) [FR Doc. 2010-25572 Filed 10-7-10;...

  3. 78 FR 31569 - National Cancer Institute; Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... [Federal Register Volume 78, Number 101 (Friday, May 24, 2013)] [Notices] [Pages 31569-31570] [FR Doc No: 2013-12377] DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National... 20, 2013. Melanie J. Gray, Program Analyst, Office of Federal Advisory Committee Policy. [FR...

  4. 78 FR 31909 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... Confidential Financial Disclosure Report (August 9, 1996, 61 FR 41572). Reason: The report is covered by the Systems of Records Notices OGE/GOVT-1, Executive Branch Personnel Public Financial Disclosure Reports and..., 2003, 68 FR 24744) and OGE/GOVT-2 Executive Branch Confidential Financial Disclosure Reports...

  5. 78 FR 34120 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... endangered species, we found that (1) the application was filed in good faith, (2) The granted permit would..., 2012. 2012. 704654 Scovill Zoo 77 FR 51819; August 27, October 31, 2012. 2012. 81326A Gomez Development.... 2012. 84250A Burmont, Inc 77 FR 61627; October 10, November 16, 2012. 2012. 681252 Cincinnati...

  6. 77 FR 75434 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-20

    ... certain BHCs. Estimated annual reporting hours: FR Y-14A: Summary, 50,160 hours; Macro scenario, 1,860... per response: FR Y-14A: Summary, 836 hours; Macro scenario, 31 hours; CCR, 382 hours; Basel III/Dodd... proposes revising the reporting frequency from annual to semi- annual for the Summary and Macro...

  7. 75 FR 29586 - Submission for OMB Review: Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-26

    ... [Federal Register Volume 75, Number 101 (Wednesday, May 26, 2010)] [Notices] [Page 29586] [FR Doc No: 2010-12641] DEPARTMENT OF LABOR Office of the Secretary Submission for OMB Review: Comment.... [FR Doc. 2010-12641 Filed 5-25-10; 8:45 am] BILLING CODE 4510-24-P...

  8. 75 FR 36393 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ...; discussion groups: Two times a year. FR 1373b, small-panel survey: Two times a year; large-panel survey, one...; discussion groups, 60 hours. FR 1373b: small-panel, 6 hours; large- panel 32 hours. Estimated average hours... techniques or other forms of information technology. DATES: Comments must be submitted on or before August...

  9. 77 FR 71777 - Trade Mission to Egypt and Kuwait

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... International Trade Administration Trade Mission to Egypt and Kuwait AGENCY: International Trade Administration... Trade Mission to Egypt and Kuwait March 10-14, 2013, published at 77 FR 33439, June 6, 2012 to revise... Mission to Egypt and Kuwait March 10-14, 2013, published at 77 FR 33439, June 6, 2012. Due to...

  10. 76 FR 62447 - Importer of Controlled Substances; Notice of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ..., 2011, and published in the Federal Register on June 16, 2011, 76 FR 35241, Chattem Chemicals, Inc... customers. As explained in the Correction to Notice of Application pertaining to Rhodes Technologies, 72 FR... the registration of Chattem Chemicals, Inc. to import the basic classes of controlled substances...

  11. 77 FR 8114 - Plan for Retrospective Analysis of Existing Rules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-14

    ... (Oct. 25, 2011). It received one comment on the preliminary plan from the law firm of Hughes Hubbard... and the identification of specific rules to be included in the plan. 76 FR 66004 (Oct. 25, 2011) and... documents filed with the agency will be filed by electronic means. See 76 FR 61937 (Oct. 6, 2011)....

  12. 76 FR 76730 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-08

    ... estimates of bank credit, balance sheet data for the U.S. banking industry, sources and uses of banks' funds... respondent data are given confidential treatment (5 U.S.C. 552 (b)(4)). The FR 2835 data, however, are not given confidential treatment. Abstract: The FR 2835 collects information from a sample of...

  13. 75 FR 6558 - Unfair or Deceptive Acts or Practices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-10

    ..., and the effective date for the amendments was July 1, 2010. 74 FR 5498 (January 29, 2009) (UDAP Rule... amendments to the UDAP Rule. 74 FR 20804 (May 5, 2009). List of Subjects in 12 CFR Part 706 Credit, Credit... payments pursuant to a pension, retirement, or disability program. (f) Household goods. Clothing,...

  14. 76 FR 20339 - Privacy Act of 1974; Systems of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... (February 20, 1996, 61 FR 6427). Dated: April 7, 2011. Morgan F. Park, Alternate OSD Federal Register Liaison Officer, Department of Defense S800.20 System name: Military Clothing Database (January 31, 2008, 73 FR 5826). Changes: * * * * * System location: Delete entry and replace with ``Data...

  15. 75 FR 62436 - Notice of Issuance of Regulatory Guide

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ... Plants.'' FOR FURTHER INFORMATION CONTACT: Bruce P. Lin, Division of Engineering, Office of Nuclear... Engineering, Office of Nuclear Regulatory Research. [FR Doc. 2010-25405 Filed 10-7-10; 8:45 am] BILLING CODE...] [FR Doc No: 2010-25405] NUCLEAR REGULATORY COMMISSION [NRC-2010-0097] Notice of Issuance of...

  16. 78 FR 9691 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ..., Annually; Liquidity risk reports, monthly. Reporters: Bank holding companies, state member banks, branches... Principal or Municipal Securities Representative Associated with a Bank Municipal Securities Dealer; Uniform... Bank Municipal Securities Dealer. Agency form number: FR MSD-4; FR MSD-5. OMB control number:...

  17. 78 FR 22415 - Amendment of Class E Airspace; Astoria, OR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-16

    ... Astoria, OR Astoria Regional Airport, Astoria, OR (Lat. 46 09'29'' N., long. 123 52'43'' W.) Seaside...'' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  18. 75 FR 71083 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-22

    ... Responsibilities for Maintaining Records About Individual,'' dated February 8, 1996 (February 20, 1996, 61 FR 6427..., 2009, 74 FR 7671) CHANGES: * * * * * SYSTEM LOCATION: Delete entry and replace with ``Student records... INDIVIDUALS COVERED BY THE SYSTEM: Delete entry and replace with ``Student records cover present, former,...

  19. 76 FR 51400 - Importer of Controlled Substances; Notice of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-18

    ... effect on May 1, 1971. DEA has investigated Rhodes Technologies to ensure that the company's registration... 28, 2011, and published in the Federal Register on May 4, 2011 76 FR 25374, Rhodes Technologies, 498... explained in the Correction to Notice of Application pertaining to Rhodes Technologies, 72 FR 3417...

  20. 7 CFR 29.1044 - Orange Red (FR).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Orange Red (FR). 29.1044 Section 29.1044 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1044 Orange Red (FR). A yellowish red....

  1. 7 CFR 29.1044 - Orange Red (FR).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Orange Red (FR). 29.1044 Section 29.1044 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1044 Orange Red (FR). A yellowish red....

  2. 7 CFR 29.1044 - Orange Red (FR).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Orange Red (FR). 29.1044 Section 29.1044 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1044 Orange Red (FR). A yellowish red....

  3. 78 FR 79658 - Environmental Impact Statement; Animal Carcass Management

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Notices] [Page 79658] [FR..., the Animal and Plant Health Inspection Service published in the Federal Register (78 FR 63959-63960... 20th day of December 2013 . Kevin Shea, Administrator, Animal and Plant Health Inspection Service....

  4. 78 FR 79728 - Proposed Collection; Comment Request for Regulation Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Notices] [Page 79728] [FR Doc No: 2013-31346] DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment... Analyst. [FR Doc. 2013-31346 Filed 12-30-13; 8:45 am] BILLING CODE 4830-01-P...

  5. 78 FR 79672 - New England Fishery Management Council; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Notices] [Pages 79672-79673] [FR Doc No: 2013-31310] DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN... Fisheries Service. [FR Doc. 2013-31310 Filed 12-30-13; 8:45 am] BILLING CODE 3510-22-P...

  6. 78 FR 79661 - Gallatin County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-31

    ... [Federal Register Volume 78, Number 251 (Tuesday, December 31, 2013)] [Notices] [Page 79661] [FR Doc No: 2013-31295] DEPARTMENT OF AGRICULTURE Forest Service Gallatin County Resource Advisory... case by case basis. Dated: December 19, 2013. Mary C Erickson, Forest Supervisor. [FR Doc....

  7. 75 FR 13139 - The National Environmental Policy Act Procedures Manual

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ... COMMISSION The National Environmental Policy Act Procedures Manual AGENCY: The National Indian Gaming... comments on the Draft NEPA Procedures Manual published in the Federal Register on December 4, 2009 (74 FR... March 4, 2010 (75 FR 3756). ] DATES: The comment period for the Draft NEPA Procedures Manual is...

  8. 75 FR 3756 - The National Environmental Policy Act Procedures Manual

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... National Indian Gaming Commission The National Environmental Policy Act Procedures Manual AGENCY: National... period for comments on the Draft NEPA Procedures Manual published in the Federal Register on December 4, 2009 (74 FR 63765, 74 FR 63787). DATES: The comment period for the Draft NEPA Procedures Manual...

  9. 77 FR 74507 - Endangered Species; Marine Mammals; Issuance of Permits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... Fish and Wildlife Service Endangered Species; Marine Mammals; Issuance of Permits AGENCY: Fish and..., marine mammals, or both. We issue these permits under the Endangered Species Act (ESA) and Marine Mammal... Gary Benmark 77 FR 41198; July 12, 2012 August 18, 2012. 045532 NOAA/National Marine 77 FR 41198;...

  10. 77 FR 50626 - Changes in Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    ... 12866 of September 30, 1993, Regulatory Planning and Review, 58 FR 51735. Executive Order 13132... seq.; Reorganization Plan No. 3 of 1978, 3 CFR, 1978 Comp., p. 329; E.O. 12127, 44 FR 19367, 3 CFR... be used to calculate flood insurance premium rates for new buildings and their contents. DATES:...

  11. 76 FR 58411 - Changes in Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... 12866 of September 30, 1993, Regulatory Planning and Review, 58 FR 51735. Executive Order 13132... et seq.; Reorganization Plan No. 3 of 1978, 3 CFR, 1978 Comp., p. 329; E.O. 12127, 44 FR 19367, 3 CFR... be used to calculate flood insurance premium rates for new buildings and their contents. DATES:...

  12. 77 FR 30219 - Changes in Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ... and Review, 58 FR 51735. Executive Order 13132, Federalism. This interim rule involves no policies..., 1978 Comp., p. 329; E.O. 12127, 44 FR 19367, 3 CFR, 1979 Comp., p. 376. Sec. 65.4 0 2. The tables... modified BFEs for new buildings and their contents. DATES: These modified BFEs are currently in effect...

  13. Astronomische Konzepte und Jenseitsvorstellungen in den Pyramidentexten.

    NASA Astrophysics Data System (ADS)

    Krauss, R.

    The Egyptian pyramid texts were first written down around 2300 B.C. They are based on the religious belief in a stellar hereafter and contain the astronomical knowledge of their authors. For example, the ecliptical belt was understood as a canal, on which moon and planets cruise; of the latter Mercury, Venus and Mars were identified. On the basis of their visibility in the course of a year the fixed stars were divided into two groups; a southern group with a period of invisibility and a northern group with continual visibility. The ecliptical "canal" was correctly identified as a division line between the two groups of fixed stars. The aim of this book is to bring these texts foreward to a better understanding of their astronomical background.

  14. Denning, William Frederick (1848-1931)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Possibly a journalist and certainly an amateur astronomer. Born in Redpost, Somerset, England. The spectacular meteor storm of 1866, and a fireball in 1869, focused his interest on meteor astronomy. In 1877 he demonstrated a steady night by night movement in the Perseid meteor radiant, which proved that meteors came from showers of dust distributed along the path of a comet. Had the distinction t...

  15. Solar System Tests of f(R) Gravity

    NASA Astrophysics Data System (ADS)

    Guo, Jun-Qi

    2014-03-01

    In this paper, we revisit the solar system tests of f(R) gravity. When the sun sits in a vacuum, the field f‧ is light, which leads to a metric different from the observations. We reobtain this result in a simpler way by directly focusing on the equations of motion for f(R) gravity in the Jordan frame (JF). The discrepancy between the metric in the f(R) gravity and the observations can be alleviated by the chameleon mechanism. The implications from the chameleon mechanism on the functional form f(R) are discussed. Considering the analogy of the solar system tests to the false vacuum decay problem, the effective potentials in different cases are also explored. The combination of analytic and numerical approaches enables us to ascertain whether an f(R) model can pass the solar system tests or not.

  16. Cosmological viable mimetic f(R) and f(R, T) theories via Noether symmetry

    NASA Astrophysics Data System (ADS)

    Momeni, D.; Myrzakulov, R.; Güdekli, E.

    2015-07-01

    Extended f(R) theories of gravity have been investigated from the symmetry point of view. We briefly has been investigated Noether symmetry of two types of extended f(R) theories: f(R, T) theory, in which curvature is coupled non-minimally to the trace of energy-momentum tensor Tμν and mimetic f(R) gravity, a theory with a scalar field degree of freedom, but ghost-free and with internal conformal symmetry. In both cases we write point-like Lagrangian for flat Friedmann-Lemaitre-Robertson-Walker (FLRW) cosmological background in the presence of ordinary matter. We have been shown that some classes of models existed with Noether symmetry in these viable extensions of f(R) gravity. As a motivated idea, we have been investigating the stability of the solutions and the bouncing and ΛCDM models using the Noether symmetries. We have been shown that in mimetic f(R) gravity bouncing and ΛCDM solutions are possible. Also a class of solutions with future singularities has been investigated.

  17. In Vitro Hemodynamic Evaluation of Five 6 Fr and 8 Fr Arterial Cannulae in Simulated Neonatal Cardiopulmonary Bypass Circuits.

    PubMed

    Wang, Shigang; Palanzo, David; Kunselman, Allen R; Ündar, Akif

    2016-01-01

    The objective of this study was to evaluate five small-bore arterial cannulae (6Fr and 8Fr) in terms of pressure drop and hemodynamic performance in simulated neonatal cardiopulmonary bypass (CPB) circuits. The experimental circuits consisted of a Jostra HL-20 roller pump, a Terumo Capiox Baby FX05 oxygenator with integrated arterial filter, an arterial and a venous tubing (1/4, 3/16, or 1/8 in × 150 cm), and an arterial cannula (Medtronic Bio-Medicus 6Fr and 8Fr, Maquet 6Fr and 8Fr, or RMI Edwards 8Fr). The circuit was primed using lactated Ringer's solution and heparinized packed human red blood cells (hematocrit 30%). Trials were conducted at different flow rates (6Fr: 200-400 mL/min; 8Fr: 200-600 mL/min) and temperatures (35 and 28°C). Flow and pressure data were collected using a custom-based data acquisition system. Higher circuit pressure, circuit pressure drop, and hemodynamic energy loss across the circuit were recorded when using small-bore arterial cannula and small inner diameter arterial tubing in a neonatal CPB circuit. The maximum preoxygenator pressures reached 449.7 ± 1.0 mm Hg (Maquet 6Fr at 400 mL/min), and 395.7 ± 0.4 mm Hg (DLP 8Fr at 600 mL/min) when using 1/8 in ID arterial tubing at 28°C. Hypothermia further increased circuit pressure drop and hemodynamic energy loss. Compared with the others, the RMI 8Fr arterial cannula had significantly lower pressure drop and energy loss. Maquet 6Fr arterial cannula had a greater pressure drop than the DLP 6Fr. A small-bore arterial cannula and arterial tubing created high circuit pressure drop and hemodynamic energy loss. Appropriate arterial cannula and arterial tubing should be considered to match the expected flow rate. Larger cannula and tubing are recommended for neonatal CPB. Low-resistance neonatal arterial cannulae need to be developed.

  18. f(R) gravity and chameleon theories

    SciTech Connect

    Brax, Philippe; Davis, Anne-Christine; Shaw, Douglas J.

    2008-11-15

    We analyze f(R) modifications of Einstein's gravity as dark energy models in the light of their connection with chameleon theories. Formulated as scalar-tensor theories, the f(R) theories imply the existence of a strong coupling of the scalar field to matter. This would violate all experimental gravitational tests on deviations from Newton's law. Fortunately, the existence of a matter dependent mass and a thin-shell effect allows one to alleviate these constraints. The thin-shell condition also implies strong restrictions on the cosmological dynamics of the f(R) theories. As a consequence, we find that the equation of state of dark energy is constrained to be extremely close to -1 in the recent past. We also examine the potential effects of f(R) theories in the context of the Eoet-wash experiments. We show that the requirement of a thin shell for the test bodies is not enough to guarantee a null result on deviations from Newton's law. As long as dark energy accounts for a sizeable fraction of the total energy density of the Universe, the constraints that we deduce also forbid any measurable deviation of the dark energy equation of state from -1. All in all, we find that both cosmological and laboratory tests imply that f(R) models are almost coincident with a {lambda}CDM model at the background level.

  19. 75 FR 2159 - In the Matter of Certain Variable Speed Wind Turbines and Components Thereof; Termination of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ..., Connecticut (``GE'') on February 7, 2008. 73 FR 16910. The complaint alleged violations of section 337 of the... the intent finding underlying the ALJ's inequitable conduct determination. 72 FR 52975 (Oct. 15,...

  20. 75 FR 2515 - TRICARE, Formerly Known as the Civilian Health and Medical Program of the Uniformed Services...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... Register on September 6, 1988, (53 FR 34285) set forth reimbursement changes that were effective for all... January 1, 1989. The final rule published in the Federal Register on July 1, 1993, (58 FR 35-400)...

  1. 75 FR 30065 - Arcelor Mittal, Including On-Site Leased Workers From Adecco, ESW, Inc., Guardsmark, Hudson...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ..., Hennepin, Illinois. The notice was published in the Federal Register on April 23, 2010 (75 FR 21355). The... published in the Federal Register on May 12, 2010 (75 FR 26793) At the request of the State, the...

  2. 78 FR 22895 - Test To Allow Customs Brokers To Pre-Certify Importers for Participation in the Importer Self...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... their own compliance with customs laws and regulations on a continuing basis. See 67 FR 41298 (June 17... notice at 67 FR 41298 (June 17, 2002)) to both CBP and the ISA pre-certifier whom they select...

  3. 75 FR 54290 - Fisheries of the Northeastern United States; Scup Fishery; Adjustment to the 2010 Winter II Quota

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-07

    .... SUPPLEMENTARY INFORMATION: NMFS published a final rule in the Federal Register on November 3, 2003 (68 FR 62250... increase table (table 4) published in the 2010 final scup specifications (74 FR 67978, December 22,...

  4. 75 FR 82420 - Self-Regulatory Organizations, The NASDAQ Stock Market LLC; Order Approving Proposed Rule Change...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-30

    ... Act Release No. 63239 (November 3, 2010), 75 FR 68846. \\4\\ See Letters from Floyd I. Wittlin and Ann F.... \\6\\ See Securities Exchange Act Release No. 58228 (July 25, 2008), 73 FR 44794 (July 31,...

  5. 78 FR 48758 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... Release Nos. 66951 (May 9, 2012), 77 FR 28647 (May 15, 2012) (SR-NASDAQ-2012-055) (establishing fee); 67292 (June 28, 2012), 77 FR 39773 (July 5, 2012) (SR-NASDAQ-2012- 073) (modifying terms and...

  6. 77 FR 77092 - Certain Devices for Improving Uniformity Used in a Backlight Module and Components Thereof and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... (collectively ``ITRI''). 76 FR 56796-97 (Sept. 14, 2011). The complaint alleges violations of section 337 in the... filed. See 77 FR 65579 (Oct. 29, 2012). Having examined the record of this investigation, including...

  7. 75 FR 11920 - General Electric Lighting-Ravenna Lamp Plant, Lighting Division, Including On-Site Leased Workers...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... Technologies, Ravenna, Ohio. The notice was published in the Federal Register on November 17, 2009 (74 FR 59252... Register on September 11, 2007 (72 FR 51844) In order to avoid an overlap in worker group coverage,...

  8. 76 FR 77552 - Certain Light-Emitting Diodes and Products Containing Same; Determination Not To Review an...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... August 18, 2011, based on a ] complaint filed by SLED. 76 FR 51396-97 (Aug. 18, 2011). A corrected Notice... Investigations will not participate as a party in this investigation. 76 FR 52348-49 (Aug. 22, 2011)....

  9. 77 FR 21527 - Foreign-Trade Zone 18-San Jose, CA Application for Reorganization Under Alternative Site Framework

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-10

    ... Alternative Site Framework An application has been submitted to the Foreign-Trade Zones (FTZ) Board (the Board... alternative site framework (ASF) adopted by the Board (74 FR 1170, 1/12/2009 (correction 74 FR 3987,...

  10. 77 FR 30505 - Cornell University, et al.; Notice of Decision on Applications for Duty-Free Entry of Scientific...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ...., Switzerland. Intended Use: See notice at 77 FR 23660, April 20, 2012. Comments: None received. Decision...: Dectris Ltd., Switzerland. Intended Use: See notice at 77 FR 23660, April 20, 2012. Comments:...

  11. 76 FR 13122 - Fisheries of the Caribbean, Gulf of Mexico, and South Atlantic; Reef Fish Fishery of the Gulf of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ...: The comment period for the proposed rule that published on January 24, 2011 (76 FR 4084), and closed... (Magnuson-Stevens Act). On January 24, 2011 (76 FR 4084), NMFS published a proposed rule to establish a...

  12. 76 FR 78241 - Limitation of Duty-Free Imports of Apparel Articles Assembled in Haiti Under the Haitian...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... Presidential Proclamations No. 8114, 72 FR 13655, 13659 (March 22, 2007), and No. 8596, 75 FR 68153 (November 4... Annex to the World Trade Organization Agreement on Textiles and Clothing (``ATC''), and the...

  13. 78 FR 79498 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-OpenDaylight...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... Act on July 1, 2013 (78 FR 39326). The last notification was filed with the Department on August 14... 16, 2013 (78 FR 56939). Patricia A. Brink, Director of Civil Enforcement, Antitrust Division....

  14. 77 FR 66907 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ... annual fee. \\7\\ Securities Exchange Act Release No. 55202 (January 30, 2007), 72 FR 6017 (February 8.... Securities Exchange Act Release No. 50838 (December 10, 2004), 69 FR 75578 (December 17, 2004) (approving...

  15. 77 FR 1125 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-09

    .... 54002 (June 16, 2006), 71 FR 36143 (June 23, 2006) (SR-NASD-2006-072) (increasing each of the fees by $30 per month); see also Securities Exchange Act Release No. 54260 (August 1, 2006), 71 FR...

  16. 78 FR 13928 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-01

    ... $0.01 per contract side. See Securities Exchange Act Release No. 68025 (October 10, 2012), 77 FR.... \\7\\ See Securities Exchange Act Release No. 68792 (January 31, 2013), 78 FR 8621 (February 6,...

  17. 78 FR 25403 - Proposed Amendment of Class E Airspace; Dayton, TN, Establishment of Class E Airspace; Cleveland...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a Regulatory Evaluation... read as follows: Authority: 49 U.S.C. 106(g); 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR,...

  18. 78 FR 10099 - Implementation of the Middle Class Tax Relief and Job Creation Act of 2012; Establishment of a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-13

    ... the Commission's rules, which were published in the Federal Register on November 29, 2012, 77 FR 71131..., (77 FR 71131). The amended rules are necessary to implement the enforcement provisions of the...

  19. 76 FR 40652 - Approval and Promulgation of Implementation Plans; California Air Resources Board-In-Use Heavy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... implementing the provisions of MARPOL Annex VI through its ocean- going vessel rule (75 FR 22895). Under these.... See 75 FR 11880 (March 12, 2010) for the most recent related EPA announcement concerning...

  20. 75 FR 31816 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Diesel After...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ... published a notice in the Federal Register pursuant to Section 6(b) of the Act on February 26, 2009 (74 FR... in the Federal Register pursuant to Section 6(b) of the Act on March 24, 2010 (75 FR 14191)....

  1. 78 FR 69541 - Labor Certification Process for Logging Employment and Non-H-2A Agricultural Employment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... Agricultural Employment of H-2A Aliens in the United States, 75 FR 6884 (Feb. 12, 2010). The effect of... rulemaking (NPRM). 74 FR 45906 (Sept. 4, 2009). After considering comments from the public on the...

  2. 78 FR 32238 - Foreign-Trade Zone 168-Dallas/Fort Worth, Texas Application for Reorganization/Expansion

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ... Order 603, 57 FR 47619, 10/19/92), on April 23, 1997 (Board Order 873, 62 FR 24081, 5/2/97), twice on May 8, 1997 (Board Orders 885 and 886, 62 FR 28445, 5/23/97), and on May 28, 1998 (Board Order 982, 63 FR 31200, 6/8/98). The zone currently consists of nine sites (one of which is temporary) totaling...

  3. 76 FR 41698 - Approval and Promulgation of Air Quality Implementation Plans; New Mexico; Section 110(a)(2...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... 10 Woodwaste Burners.... 11/30/1995 9/26/1997, 62 FR 50514 Part 11 Asphalt Process 11/30/1995 9/26.../1995 9/26/1997, 62 FR 50514 Equipment-Sulfur Dioxide. Part 32 Coal Burning 11/30/1995 9/26/1997, 62 FR... 40 Sulfuric Acid 11/30/1995 9/26/1997, 62 FR 50514 Production Units- Sulfur Dioxide, Acid Mist...

  4. 75 FR 18134 - Function and Reliability Flight Testing for Turbine-Powered Airplanes Weighing 6,000 Pounds or Less

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78) or you...'' (see 12 FR 2086, March 29, 1947). A related rulemaking included a reference to a study of accidents and maintenance issues of then relatively new model aircraft (see 12 FR 1028, February 13, 1947). That...

  5. 76 FR 64229 - Function and Reliability Flight Testing for Turbine-Powered Airplanes Weighing 6,000 Pounds or Less

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... Certificated Weight.'' (See 69 FR 5239, February 3, 2004.) In that notice, we announced our intention to.... (See 75 FR 50853, August 18, 2010.) This final rule will eliminate the need for issuing special...-Powered Airplanes Weighing 6,000 Pounds or Less.'' (See 75 FR 18134, April 9, 2010.) In that NPRM,...

  6. 76 FR 76097 - Amendment to the International Traffic in Arms Regulations: Establishment of U.S. Munitions List...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... List: Revising Descriptions of Items and Foreign Availability,'' 75 FR 76664 (December 9, 2010) and ``Revision to the United States Munitions List,'' 75 FR 76935 (December 10, 2010)). The notices also called... designed'' in the December 2010 ANPRM (75 FR 76935) and noted the term would be used minimally in the...

  7. 76 FR 2829 - Approval and Promulgation of Air Quality Implementation Plans; Virginia; Adoption of 8-hour Ozone...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ... NAAQS for ozone on March 27, 2008 (73 FR 16436). II. Summary of SIP Revision On September 27, 2010, the... Budget under Executive Order 12866 (58 FR 51735, October 4, 1993); Does not impose an information...); Does not have Federalism implications as specified in Executive Order 13132 (64 FR 43255, August...

  8. 78 FR 41013 - Medicare and Medicaid Programs; Home Health Prospective Payment System Rate Update for CY 2014...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... INFORMATION CONTACT: Elmer Barksdale, (410) 786-1943. SUPPLEMENTARY INFORMATION: I. Background In FR Doc. 2013-15766, published on Wednesday, July 3, 2013 (78 FR 40272), there was an error that is identified and... was ``-$18.6 Million'' instead of ``$18.6 Million.'' IV. Correction of Errors In FR Doc....

  9. 78 FR 19510 - Endangered and Threatened Wildlife and Plants; Initiation of 5-Year Reviews of 56 Species in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-01

    ...)....... 62 FR 4172; 12/01/ Connie Rutherford, U.S. Fish and vetch. 1997. Listing and Wildlife Service... lentiginosus var. Fish slough milk- Endangered........ U.S.A. (CA)....... 63 FR 53596, 06/10/ Connie Rutherford... milk- Endangered........ U.S.A. (CA)....... 63 FR 43100; 08/12/ Connie Rutherford (above). vetch....

  10. 78 FR 72863 - Circular Welded Carbon Quality Steel Pipe From the People's Republic of China: Continuation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-04

    ...'') Review, 78 FR 33063 (June 3, 2013). \\2\\ See Circular Welded Carbon Quality Steel Pipe From the People's... FR 60849 (October 2, 2013). \\3\\ See Circular Welded Carbon-Quality Steel Pipe from China, 78 FR 70069... International Trade Administration Circular Welded Carbon Quality Steel Pipe From the People's Republic of...

  11. 78 FR 25756 - Announcement of Funding Awards for Office of Healthy Homes and Lead Hazard Control (OHHLHC) Grant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-02

    ... URBAN DEVELOPMENT [Docket No. FR-5600-FA-04A; Docket No. FR-5600-FA-04B; Docket No. FR- 5600-FA-07... accordance with Section 102(a)(4)(C) of the Department of Housing and Urban Development Reform Act of 1989..., Department of Housing and Urban Development, Office of Healthy Homes and Lead Hazard Control, Room 8236,...

  12. 78 FR 41154 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ...), 71 FR 58460, 58461 (October 3, 2006) (SR-PCX- 2005-53). The Exchange also believes that the proposed... credit. \\14\\ See Securities Exchange Act Release No. 68848 (February 6, 2013), 78 FR 9985, 9986 (February... Securities Exchange Act Release No. 69566 (May 13, 2013), 78 FR 29193 (May 17, 2013) (SR-NASDAQ-2013-...

  13. 77 FR 56672 - Certain Light-Emitting Diodes and Products Containing the Same; Determination To Review a Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ...-56674] [FR Doc No: 2012-22517] INTERNATIONAL TRADE COMMISSION [Investigation No. 337-TA-784] Certain... (``the `090 patent''); 7,151,283 (``the `283 patent''); and 7,271,425 (``the `425 patent''). 76 FR 40746... Secretary to the Commission. [FR Doc. 2012-22517 Filed 9-12-12; 8:45 am] BILLING CODE 7020-02-P...

  14. 76 FR 68793 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Planning and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... [Federal Register Volume 76, Number 215 (Monday, November 7, 2011)] [Notices] [Page 68793] [FR Doc... participation in ACRS meetings were published in the Federal Register on October 17, 2011 (76 FR 64127-64128... Assistant, Reactor Safety Branch, Advisory Committee on Reactor Safeguards. [FR Doc. 2011-28738 Filed...

  15. 78 FR 70533 - Certain Activated Carbon From the People's Republic of China: Final Results of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-26

    ...] [FR Doc No: 2013-28359] DEPARTMENT OF COMMERCE International Trade Administration [A-570-904] Certain... Fourth Antidumping Duty Administrative Review; 2011-2012, 78 FR 26748 (May 8, 2013) (``Preliminary...., 78 FR at 26749. \\4\\ See Memorandum to Christian Marsh, Deputy Assistant Secretary, Antidumping...

  16. 78 FR 41176 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... Exchange Act Release Nos. 68460 (December 18, 2012), 77 FR 76145 (December 26, 2012) (SR-NYSEMKT-2012-41) (approval order) (``NYSE MKT filing''); 68461 (December 18, 2012), 77 FR 76155 (December 26, 2012) (SR-NYSEArca-2012-94) (approval order) (``NYSE Arca filing''); and 68606 (January 9, 2013), 78 FR 3065...

  17. 77 FR 10476 - Certain New Pneumatic Off-the-Road Tires From the People's Republic of China: Notice of Second...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... FR 66349 (October 28, 2010). On October 7, 2011, the Department published its preliminary results of...--2010 Antidumping Duty Administrative Review and Intent to Rescind, in Part, 76 FR 62356 (October 7... Antidumping Duty Order, 77 FR 6536 (February 8, 2012). Extension of Time Limit for Final Results Section...

  18. 78 FR 36611 - Self-Regulatory Organizations; New York Stock Exchange LLC; Order Approving Proposed Rule Change...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-18

    ...), 78 FR 25327 (``Notice''). II. Description of the Proposal On July 30, 2007, FINRA's predecessor, the... Nos. 56148 (July 26, 2007), 72 FR 42146 (August 1, 2007) (order approving the Agreement); 56147 (July 26, 2007), 72 FR 42166 (August 1, 2007) (SR-NASD-2007- 054) (order approving the incorporation...

  19. 78 FR 48734 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ...\\ See Securities Exchange Act Release Nos. 68460 (December 18, 2012), 77 FR 76145 (December 26, 2012) (SR-NYSEMKT-2012-41) (approval order) (``NYSE MKT filing''); 68461 (December 18, 2012), 77 FR 76155...), 78 FR 3065 (January 15, 2013) (SR-CBOE-2012-131) (notice of filing and immediate...

  20. 78 FR 48744 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... standard (monthly) option. \\4\\ See Securities Exchange Act Release Nos. 68460 (December 18, 2012), 77 FR... 18, 2012), 77 FR 76155 (December 26, 2012) (SR-NYSEArca-2012-94) (approval order) (``NYSE Arca filing''); 68606 (January 9, 2013), 78 FR 3065 (January 15, 2013) (SR-CBOE-2012-131) (notice of filing...