Science.gov

Sample records for etici della ricerca

  1. Disegno dello studio genomico, ambientale, microbiomico e metabolomico sulla celiachia: un approccio al futuro della prevenzione personalizzata della celiachia

    PubMed Central

    SERENA, GLORIA; LEONARD, MAUREEN M.; CAMHI, STEPHANIE; HUEDO-MEDINA, TANIA B.; FASANO, ALESSIO

    2017-01-01

    Riassunto Negli ultimi anni abbiamo assistito a un fiorire di novità cliniche e scientifiche sulla celiachia (CE), ma forse la novità più importante che influenzerà il futuro della ricerca e della clinica in questo campo riguarda la storia naturale della malattia. Per molti anni si è creduto che la predisposizione genetica e l’esposizione al glutine fossero necessarie e sufficienti allo sviluppo della CE. Studi recenti, però suggeriscono che la perdita di tolleranza al glutine possa apparire in qualsiasi momento della vita a seguito di altri elementi. Inoltre, diversi fattori ambientali conosciuti per il loro ruolo nell’influenzare la composizione della microflora intestinale sono anche stati considerati legati allo sviluppo della CE. Tra questi fattori sono inclusi la modalità di parto, la dieta dell’infante e l’uso di antibiotici. A tutt’oggi, nessuno studio longitudinale di ampia scala ha determinato se e come la composizione del microbioma e il suo profilo metabolomico possano influenzare la perdita di tolleranza al glutine e il successivo sviluppo della CE in soggetti geneticamente predisposti. In questo articolo descriviamo uno studio prospettico, multicentrico e longitudinale su infanti a rischio per la CE che utilizzerà diverse tecniche per approfondire il ruolo che il microbioma intestinale ha durante i primi passaggi dello sviluppo della malattia autoimmune. PMID:27362724

  2. Attitudine Linguistica e Acquisizione della Competenza. Un Progetto di Ricerca (Linguistic Aptitude and Acquisition of Competence. A Research Project).

    ERIC Educational Resources Information Center

    Sorace, Antonella

    1982-01-01

    Subjects were 45 Italians who were studying English as a second language. They were administered the Modern Language Aptitude Test and a cloze test and were asked to complete a questionnaire regarding their language study. The researcher then analyzed the interrelationships among the subjects' linguistic aptitude, language study history, and level…

  3. Attitudine Linguistica e Acquisizione della Competenza. Un Progetto di Ricerca (Linguistic Aptitude and Acquisition of Competence. A Research Project).

    ERIC Educational Resources Information Center

    Sorace, Antonella

    1982-01-01

    Subjects were 45 Italians who were studying English as a second language. They were administered the Modern Language Aptitude Test and a cloze test and were asked to complete a questionnaire regarding their language study. The researcher then analyzed the interrelationships among the subjects' linguistic aptitude, language study history, and level…

  4. L'attività della Sezione di Ricerca "Asteroidi" della U.A.I. (English Title: "Asteroidi" U.A.I. Research Section activity)

    NASA Astrophysics Data System (ADS)

    Galli, G.; Foglia, S.

    2017-08-01

    This paper describes the activity of UAI Asteroid section and the state of art of astrometry in Italy. The website of the Section and the capability of the same to suggest interesting targets are introduced so that any observer can take part to the scientific research in this important field of astronomy.

  5. Le verifiche della relatività generale

    NASA Astrophysics Data System (ADS)

    Tempesti, Piero

    2005-10-01

    La relatività di Einstein. La relatività generale messa alla prova. Le tre verifiche classiche: L'avanzamento del perielio di Mercurio - La deflessione della luce - Il redshift gravitazionale. Le verifiche di seconda generazione: Il rallentamento della luce - L'effetto Nordtvedt - Le onde gravitazionali e la "pulsar binaria".

  6. Binding of GID1 to DELLAs promotes dissociation of GAF1 from DELLA in GA dependent manner.

    PubMed

    Fukazawa, Jutarou; Ito, Takeshi; Kamiya, Yuji; Yamaguchi, Shinjiro; Takahashi, Yohsuke

    2015-01-01

    Gibberellins (GAs) are important phytohormones for plant growth and development. DELLAs are members of the plant-specific GRAS protein family and act as repressors of GA signaling. DELLAs are rapidly degraded in the presence of GAs. GA-GID1-DELLA complexes are recognized and ubiquitinated by the SCF(SLY) complex. The sleepy1 (sly1) F-box mutant exhibits dwarfism and low-germination phenotypes due to high accumulation of DELLAs. Overexpression of GID1 in the sly1 mutant partially rescues these phenotypes without degradation of DELLAs suggesting that proteolysis independent regulation of DELLAs exists in GA signaling. But the molecular mechanisms of non-proteolytic regulation of DELLA are largely unknown. Recently we identified a DELLA binding transcription factor, GAI-ASSOCIATED FACTOR1 (GAF1). GAF1 also interacts with co-repressor TOPLESS RELATED (TPR) in nuclei. DELLAs and TPR act as coactivator and corepressor of GAF1, respectively. GAs converts the GAF1 complex from transcriptional activator to repressor via degradation of DELLAs. The overexpression of ΔPAM, lacking of DELLAs binding region of GAF1, partially rescue dwarf phenotypes of GA deficient or GA insensitive mutant. In this study, we investigate the relationship between non-proteolytic regulation of DELLAs and GA signaling via DELLA-GAF1 complex using modified yeast two-hybrid system.

  7. Fruit growth in Arabidopsis occurs via DELLA-dependent and DELLA-independent gibberellin responses.

    PubMed

    Fuentes, Sara; Ljung, Karin; Sorefan, Karim; Alvey, Elizabeth; Harberd, Nicholas P; Østergaard, Lars

    2012-10-01

    Fruit growth and development depend on highly coordinated hormonal activities. The phytohormone gibberellin (GA) promotes growth by inducing degradation of the growth-repressing DELLA proteins; however, the extent to which DELLA proteins contribute to GA-mediated gynoecium and fruit development remains to be clarified. Here, we provide an in-depth characterization of the role of DELLA proteins in Arabidopsis thaliana fruit growth. We show that DELLA proteins are key regulators of reproductive organ size and important for ensuring optimal fertilization. We demonstrate that the seedless fruit growth (parthenocarpy) observed in della mutants can be directly attributed to the constitutive activation of GA signaling. It has been known for >75 years that another hormone, auxin, can induce formation of seedless fruits. Using mutants with complete lack of DELLA activity, we show here that auxin-induced parthenocarpy occurs entirely through GA signaling in Arabidopsis. Finally, we uncover the existence of a DELLA-independent GA response that promotes fruit growth. This response requires GIBBERELLIN-INSENSITIVE DWARF1-mediated GA perception and a functional 26S proteasome and involves the basic helix-loop-helix protein SPATULA as a key component. Taken together, our results describe additional complexities in GA signaling during fruit development, which may be particularly important to optimize the conditions for successful reproduction.

  8. Gibberellin signaling: a theme and variations on DELLA repression

    USDA-ARS?s Scientific Manuscript database

    DELLA proteolysis through the ubiquitin-proteasome pathway or through the proteolysis-independent mechanisms. GA triggers DELLA proteolysis via a series of protein-protein interactions. GA binding to the GID1 GA receptor increases the affinity of GID1 for DELLA leading to the formation of the GID1-G...

  9. Evolutionary Analysis of DELLA-Associated Transcriptional Networks.

    PubMed

    Briones-Moreno, Asier; Hernández-García, Jorge; Vargas-Chávez, Carlos; Romero-Campero, Francisco J; Romero, José M; Valverde, Federico; Blázquez, Miguel A

    2017-01-01

    DELLA proteins are transcriptional regulators present in all land plants which have been shown to modulate the activity of over 100 transcription factors in Arabidopsis, involved in multiple physiological and developmental processes. It has been proposed that DELLAs transduce environmental information to pre-wired transcriptional circuits because their stability is regulated by gibberellins (GAs), whose homeostasis largely depends on environmental signals. The ability of GAs to promote DELLA degradation coincides with the origin of vascular plants, but the presence of DELLAs in other land plants poses at least two questions: what regulatory properties have DELLAs provided to the behavior of transcriptional networks in land plants, and how has the recruitment of DELLAs by GA signaling affected this regulation. To address these issues, we have constructed gene co-expression networks of four different organisms within the green lineage with different properties regarding DELLAs: Arabidopsis thaliana and Solanum lycopersicum (both with GA-regulated DELLA proteins), Physcomitrella patens (with GA-independent DELLA proteins) and Chlamydomonas reinhardtii (a green alga without DELLA), and we have examined the relative evolution of the subnetworks containing the potential DELLA-dependent transcriptomes. Network analysis indicates a relative increase in parameters associated with the degree of interconnectivity in the DELLA-associated subnetworks of land plants, with a stronger effect in species with GA-regulated DELLA proteins. These results suggest that DELLAs may have played a role in the coordination of multiple transcriptional programs along evolution, and the function of DELLAs as regulatory 'hubs' became further consolidated after their recruitment by GA signaling in higher plants.

  10. Cloning and characterization of DELLA genes in Artemisia annua.

    PubMed

    Shen, Q; Cui, J; Fu, X Q; Yan, T X; Tang, K X

    2015-08-21

    Gibberellins (GA) are some of the most important phytohormones involved in plant development. DELLA proteins are negative regulators of GA signaling in many plants. In this study, the full-length cDNA sequences of three DELLA genes were cloned from Artemisia annua. Phylogenetic analysis revealed that AaDELLA1 and AaDELLA2 were located in the same cluster, but AaDELLA3 was not. Subcellular localization analysis suggested that AaDELLAs can be targeted to the nucleus and/or cytoplasm. Real-time PCR indicated that all three AaDELLA genes exhibited the highest expression in seeds. Expression of all AaDELLA genes was enhanced by exogenous MeJA treatment but inhibited by GA3 treatment. Yeast two-hybrid assay showed that AaDELLAs could interact with basic helix-loop-helix transcription factor AaMYC2, suggesting that GA and JA signaling may be involved in cross-talk via DELLA and MYC2 interaction in A. annua.

  11. DELLA genes restrict inflorescence meristem function independently of plant height.

    PubMed

    Serrano-Mislata, Antonio; Bencivenga, Stefano; Bush, Max; Schiessl, Katharina; Boden, Scott; Sablowski, Robert

    2017-08-21

    DELLA proteins associate with transcription factors to control plant growth in response to gibberellin (1) . Semi-dwarf DELLA mutants with improved harvest index and decreased lodging greatly improved global food security during the 'green revolution' in the 1960-1970s (2) . However, DELLA mutants are pleiotropic and the developmental basis for their effects on plant architecture remains poorly understood. Here, we show that DELLA proteins have genetically separable roles in controlling stem growth and the size of the inflorescence meristem, where flowers initiate. Quantitative three-dimensional image analysis, combined with a genome-wide screen for DELLA-bound loci in the inflorescence tip, revealed that DELLAs limit meristem size in Arabidopsis by directly upregulating the cell-cycle inhibitor KRP2 in the underlying rib meristem, without affecting the canonical WUSCHEL-CLAVATA meristem size regulators (3) . Mutation of KRP2 in a DELLA semi-dwarf background restored meristem size, but not stem growth, and accelerated flower production. In barley, secondary mutations in the DELLA gain-of-function mutant Sln1d (4) also uncoupled meristem and inflorescence size from plant height. Our work reveals an unexpected and conserved role for DELLA genes in controlling shoot meristem function and suggests how dissection of pleiotropic DELLA functions could unlock further yield gains in semi-dwarf mutants.During gibberellic acid signalling, DELLAs restrict the size of the shoot apical meristem by targeting the cell cycle regulator KRP2. The roles of DELLAs in the shoot apical meristem and stem growth can be genetically uncoupled in Arabidopsis and barley.

  12. DELLA proteins regulate arbuscule formation in arbuscular mycorrhizal symbiosis.

    PubMed

    Floss, Daniela S; Levy, Julien G; Lévesque-Tremblay, Véronique; Pumplin, Nathan; Harrison, Maria J

    2013-12-17

    Most flowering plants are able to form endosymbioses with arbuscular mycorrhizal fungi. In this mutualistic association, the fungus colonizes the root cortex and establishes elaborately branched hyphae, called arbuscules, within the cortical cells. Arbuscule development requires the cellular reorganization of both symbionts, and the resulting symbiotic interface functions in nutrient exchange. A plant symbiosis signaling pathway controls the development of the symbiosis. Several components of the pathway have been identified, but transcriptional regulators that control downstream pathways for arbuscule formation are still unknown. Here we show that DELLA proteins, which are repressors of gibberellic acid (GA) signaling and function at the nexus of several signaling pathways, are required for arbuscule formation. Arbuscule formation is severely impaired in a Medicago truncatula Mtdella1/Mtdella2 double mutant; GA treatment of wild-type roots phenocopies the della double mutant, and a dominant DELLA protein (della1-Δ18) enables arbuscule formation in the presence of GA. Ectopic expression of della1-Δ18 suggests that DELLA activity in the vascular tissue and endodermis is sufficient to enable arbuscule formation in the inner cortical cells. In addition, expression of della1-Δ18 restores arbuscule formation in the symbiosis signaling pathway mutant cyclops/ipd3, indicating an intersection between DELLA and symbiosis signaling for arbuscule formation. GA signaling also influences arbuscule formation in monocots, and a Green Revolution wheat variety carrying dominant DELLA alleles shows enhanced colonization but a limited growth response to arbuscular mycorrhizal symbiosis.

  13. DELLA proteins regulate arbuscule formation in arbuscular mycorrhizal symbiosis

    PubMed Central

    Floss, Daniela S.; Levy, Julien G.; Lévesque-Tremblay, Véronique; Pumplin, Nathan; Harrison, Maria J.

    2013-01-01

    Most flowering plants are able to form endosymbioses with arbuscular mycorrhizal fungi. In this mutualistic association, the fungus colonizes the root cortex and establishes elaborately branched hyphae, called arbuscules, within the cortical cells. Arbuscule development requires the cellular reorganization of both symbionts, and the resulting symbiotic interface functions in nutrient exchange. A plant symbiosis signaling pathway controls the development of the symbiosis. Several components of the pathway have been identified, but transcriptional regulators that control downstream pathways for arbuscule formation are still unknown. Here we show that DELLA proteins, which are repressors of gibberellic acid (GA) signaling and function at the nexus of several signaling pathways, are required for arbuscule formation. Arbuscule formation is severely impaired in a Medicago truncatula Mtdella1/Mtdella2 double mutant; GA treatment of wild-type roots phenocopies the della double mutant, and a dominant DELLA protein (della1-Δ18) enables arbuscule formation in the presence of GA. Ectopic expression of della1-Δ18 suggests that DELLA activity in the vascular tissue and endodermis is sufficient to enable arbuscule formation in the inner cortical cells. In addition, expression of della1-Δ18 restores arbuscule formation in the symbiosis signaling pathway mutant cyclops/ipd3, indicating an intersection between DELLA and symbiosis signaling for arbuscule formation. GA signaling also influences arbuscule formation in monocots, and a Green Revolution wheat variety carrying dominant DELLA alleles shows enhanced colonization but a limited growth response to arbuscular mycorrhizal symbiosis. PMID:24297892

  14. Fruit Growth in Arabidopsis Occurs via DELLA-Dependent and DELLA-Independent Gibberellin Responses[W][OA

    PubMed Central

    Fuentes, Sara; Ljung, Karin; Sorefan, Karim; Alvey, Elizabeth; Harberd, Nicholas P.; Østergaard, Lars

    2012-01-01

    Fruit growth and development depend on highly coordinated hormonal activities. The phytohormone gibberellin (GA) promotes growth by inducing degradation of the growth-repressing DELLA proteins; however, the extent to which DELLA proteins contribute to GA-mediated gynoecium and fruit development remains to be clarified. Here, we provide an in-depth characterization of the role of DELLA proteins in Arabidopsis thaliana fruit growth. We show that DELLA proteins are key regulators of reproductive organ size and important for ensuring optimal fertilization. We demonstrate that the seedless fruit growth (parthenocarpy) observed in della mutants can be directly attributed to the constitutive activation of GA signaling. It has been known for >75 years that another hormone, auxin, can induce formation of seedless fruits. Using mutants with complete lack of DELLA activity, we show here that auxin-induced parthenocarpy occurs entirely through GA signaling in Arabidopsis. Finally, we uncover the existence of a DELLA-independent GA response that promotes fruit growth. This response requires GIBBERELLIN-INSENSITIVE DWARF1–mediated GA perception and a functional 26S proteasome and involves the basic helix-loop-helix protein SPATULA as a key component. Taken together, our results describe additional complexities in GA signaling during fruit development, which may be particularly important to optimize the conditions for successful reproduction. PMID:23064323

  15. DELLA protein function in growth responses to canopy signals.

    PubMed

    Djakovic-Petrovic, Tanja; de Wit, Mieke; Voesenek, Laurentius A C J; Pierik, Ronald

    2007-07-01

    Plants can sense neighbour competitors through light-quality signals and respond with shade-avoidance responses. These include increased shoot elongation, which enhances light capture and thus competitive power. Such plant-plant interactions therefore profoundly affect plant development in crowded populations. Shade-avoidance responses are tightly coordinated by interactions between light signals and hormones, with essential roles for the phytochrome B photoreceptor [sensing the red:far red (R:FR) ratio] and the hormone gibberellin (GA). The family of growth-suppressing DELLA proteins are targets for GA signalling and are proposed to integrate signals from other hormones. However, the importance of these regulators has not been studied in the ecologically relevant, complex realm of plant canopies. Here we show that DELLA abundance is regulated during growth responses to neighbours in dense Arabidopsis stands. This occurs in a R:FR-dependent manner in petioles, depends on GA, and matches the induction kinetics of petiole elongation. Similar interactions were observed in the growth response of seedling hypocotyls and are general for a second canopy signal, reduced blue light. Enhanced DELLA stability in the gai mutant inhibits shade-avoidance responses, indicating that DELLA proteins constrain shade-avoidance. However, using multiple DELLA knockout mutants, we show that the observed DELLA breakdown is not sufficient to induce shade-avoidance in petioles, but plays a more central role in hypocotyls. These data provide novel information on the regulation of shade-avoidance under ecologically important conditions, defining the importance of DELLA proteins and GA and unravelling the existence of GA- and DELLA-independent mechanisms.

  16. Lifting DELLA repression of Arabidopsis seed germination by nonproteolytic gibberellin signaling

    USDA-ARS?s Scientific Manuscript database

    DELLA repression of Arabidopsis seed germination can be lifted through the ubiquitin-proteasome pathway and proteolysis-independent GA signaling. GA-binding to the GID1 (GIBBERELLIN-INSENSITIVE DWARF1) GA receptors stimulates GID1-GA-DELLA complex formation which in turn triggers DELLA protein ubiq...

  17. The "Accademia della Crusca" in Italy: Past and Present

    ERIC Educational Resources Information Center

    Tosi, Arturo

    2011-01-01

    An informal organisation that is becoming quite influential in the spread of Italian in Italy, as well as abroad, is the "Accademia della Crusca" which began its activities during the Renaissance, under quite different auspices. Founded in Florence in 1582-1583, this Academy was inspired by the theories of Pietro Bembo (1470-1547), a…

  18. Arabidopsis CBF3 and DELLAs positively regulate each other in response to low temperature

    PubMed Central

    Zhou, Mingqi; Chen, Hu; Wei, Donghui; Ma, Hong; Lin, Juan

    2017-01-01

    The C-repeat binding factor (CBF) is crucial for regulation of cold response in higher plants. In Arabidopsis, the mechanism of CBF3-caused growth retardation is still unclear. Our present work shows that CBF3 shares the similar repression of bioactive gibberellin (GA) as well as upregulation of DELLA proteins with CBF1 and -2. Genetic analysis reveals that DELLAs play an essential role in growth reduction mediated by CBF1, -2, -3 genes. The in vivo and in vitro evidences demonstrate that GA2-oxidase 7 gene is a novel CBF3 regulon. Meanwhile, DELLAs contribute to cold induction of CBF1, -2, -3 genes through interaction with jasmonate (JA) signaling. We conclude that CBF3 promotes DELLAs accumulation through repressing GA biosynthesis and DELLAs positively regulate CBF3 involving JA signaling. CBFs and DELLAs collaborate to retard plant growth in response to low temperature. PMID:28051152

  19. A Pivotal Role of DELLAs in Regulating Multiple Hormone Signals.

    PubMed

    Davière, Jean-Michel; Achard, Patrick

    2016-01-04

    Plant phenotypic plasticity is controlled by diverse hormone pathways, which integrate and convey information from multiple developmental and environmental signals. Moreover, in plants many processes such as growth, development, and defense are regulated in similar ways by multiple hormones. Among them, gibberellins (GAs) are phytohormones with pleiotropic actions, regulating various growth processes throughout the plant life cycle. Previous work has revealed extensive interplay between GAs and other hormones, but the molecular mechanism became apparent only recently. Molecular and physiological studies have demonstrated that DELLA proteins, considered as master negative regulators of GA signaling, integrate multiple hormone signaling pathways through physical interactions with transcription factors or regulatory proteins from different families. In this review, we summarize the latest progress in GA signaling and its direct crosstalk with the main phytohormone signaling, emphasizing the multifaceted role of DELLA proteins with key components of major hormone signaling pathways.

  20. Lifting DELLA Repression of Arabidopsis Seed Germination by Nonproteolytic Gibberellin Signaling1[C][W][OPEN

    PubMed Central

    Ariizumi, Tohru; Hauvermale, Amber L.; Nelson, Sven K.; Hanada, Atsushi; Yamaguchi, Shinjiro; Steber, Camille M.

    2013-01-01

    DELLA repression of Arabidopsis (Arabidopsis thaliana) seed germination can be lifted either through DELLA proteolysis by the ubiquitin-proteasome pathway or through proteolysis-independent gibberellin (GA) hormone signaling. GA binding to the GIBBERELLIN-INSENSITIVE DWARF1 (GID1) GA receptors stimulates GID1-GA-DELLA complex formation, which in turn triggers DELLA protein ubiquitination and proteolysis via the SCFSLY1 E3 ubiquitin ligase and 26S proteasome. Although DELLA cannot be destroyed in the sleepy1-2 (sly1-2) F-box mutant, long dry after-ripening and GID1 overexpression can relieve the strong sly1-2 seed dormancy phenotype. It appears that sly1-2 seed dormancy results from abscisic acid (ABA) signaling downstream of DELLA, since dormant sly1-2 seeds accumulate high levels of ABA hormone and loss of ABA sensitivity rescues sly1-2 seed germination. DELLA positively regulates the expression of XERICO, an inducer of ABA biosynthesis. GID1b overexpression rescues sly1-2 germination through proteolysis-independent DELLA down-regulation associated with increased expression of GA-inducible genes and decreased ABA accumulation, apparently as a result of decreased XERICO messenger RNA levels. Higher levels of GID1 overexpression are associated with more efficient sly1 germination and increased GID1-GA-DELLA complex formation, suggesting that GID1 down-regulates DELLA through protein binding. After-ripening results in increased GA accumulation and GID1a-dependent GA signaling, suggesting that after-ripening triggers GA-stimulated GID1-GA-DELLA protein complex formation, which in turn blocks DELLA transcriptional activation of the XERICO inhibitor of seed germination. PMID:23818171

  1. Auxin acts independently of DELLA proteins in regulating gibberellin levels.

    PubMed

    Reid, James B; Davidson, Sandra E; Ross, John J

    2011-03-01

    Shoot elongation is a vital process for plant development and productivity, in both ecological and economic contexts. Auxin and bioactive gibberellins (GAs), such as GA1, play critical roles in the control of elongation, along with environmental and endogenous factors, including other hormones such as the brassinosteroids. The effect of auxins, such as indole-3-acetic acid (IAA), is at least in part mediated by its effect on GA metabolism, since auxin up-regulates biosynthesis genes such as GA 3-oxidase and GA 20-oxidase and down regulates GA catabolism genes such as GA 2-oxidases, leading to elevated levels of bioactive GA 1. In our recent paper, we have provided evidence that this action of IAA is largely independent of DELLA proteins, the negative regulators of GA action, since the auxin effects are still present in the DELLA-deficient la cry-s genotype of pea. This was a crucial issue to resolve, since like auxin, the DELLAs also promote GA 1 synthesis and inhibit its deactivation. DELLAs are deactivated by GA, and thereby mediate a feedback system by which bioactive GA regulates its own level. However, our recent results, in themselves, do not show the generality of the auxin-GA relationship across species and phylogenetic groups or across different tissue types and responses. Further, they do not touch on the ecological benefits of the auxin-GA interaction. These issues are discussed below as well as the need for the development of suitable experimental systems to allow this process to be examined.

  2. [The Istituto di Storia della Medicina archive and video collection].

    PubMed

    Aruta, Alessandro; De Angelis, Elio

    2006-01-01

    The Istituto di Storia della Medicina at Rome University was to a certain extent a one-man achievement. Founded by Adalberto Pazzini in 1937, its collections comprehended books, objects, as well as photographs, movies, and other didactic video. The Istituto was also a center for publications, conferences and meetings. The archival sources that document its activity have been re-evaluated and restored in recent years, together with the collections housed in the Library and in the Museum.

  3. Functional analysis of synthetic DELLA domain peptides and bioactive gibberellin assay using surface plasmon resonance technology.

    PubMed

    Zhao, Zhuoya; Xing, Zenan; Zhou, Min; Chen, Yi; Li, Chenzhong; Wang, Ruozhong; Xu, Wenzhong; Ma, Mi

    2015-11-01

    DELLA proteins and phytohormone gibberellin act together to control convergence point of plant development. A gibberellin-bound nuclear receptor that interacts with the N-terminal domain of DELLA proteins is required for gibberellin induced degradation of DELLA proteins. N-terminal DELLA domain includes two conserved motifs: DELLA and VHYNP. However, their respective functions remain unclear. Meanwhile, the identification and detection of several bioactive gibberellins from the more than 100 gibberellin metabolites are overwhelmingly difficult for their similar structures. Using in vitro biochemical approach, our work demonstrates for the first time that the synthetic GAI N-terminal DELLA domain peptides have similar bioactive function as the expressed protein to interact with AtGID1a receptor. Furthermore, our results reveal that DELLA motif is vitally important region and DELLA segment is essentially required region to recognize AtGID1a receptor. Finally, based on bioactive GA-dependent of the interaction between AtGID1a and DELLA protein, we generated a new method that could identify and detect bioactive GAs accurately and rapidly with surface plasmon resonance assays. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Uncovering DELLA-Independent Gibberellin Responses by Characterizing New Tomato procera Mutants.

    PubMed

    Livne, Sivan; Lor, Vai S; Nir, Ido; Eliaz, Natanella; Aharoni, Asaph; Olszewski, Neil E; Eshed, Yuval; Weiss, David

    2015-06-01

    Gibberellin (GA) regulates plant development primarily by triggering the degradation/deactivation of the DELLA proteins. However, it remains unclear whether all GA responses are regulated by DELLAs. Tomato (Solanum lycopersicum) has a single DELLA gene named PROCERA (PRO), and its recessive pro allele exhibits constitutive GA activity but retains responsiveness to external GA. In the loss-of-function mutant pro(ΔGRAS), all examined GA developmental responses were considerably enhanced relative to pro and a defect in seed desiccation tolerance was uncovered. As pro, but not pro(ΔGRAS), elongation was promoted by GA treatment, pro may retain residual DELLA activity. In agreement with homeostatic feedback regulation of the GA biosynthetic pathway, we found that GA20oxidase1 expression was suppressed in pro(ΔGRAS) and was not affected by exogenous GA3. In contrast, expression of GA2oxidase4 was not affected by the elevated GA signaling in pro(ΔGRAS) but was strongly induced by exogenous GA3. Since a similar response was found in Arabidopsis thaliana plants with impaired activity of all five DELLA genes, we suggest that homeostatic GA responses are regulated by both DELLA-dependent and -independent pathways. Transcriptome analysis of GA-treated pro(ΔGRAS) leaves suggests that 5% of all GA-regulated genes in tomato are DELLA independent.

  5. Maize DELLA proteins dwarf plant8 and dwarf plant9 as modulators of plant development.

    PubMed

    Lawit, Shai J; Wych, Heidi M; Xu, Deping; Kundu, Suman; Tomes, Dwight T

    2010-11-01

    DELLA proteins are nuclear-localized negative regulators of gibberellin signaling found ubiquitously throughout higher plants. Dominant dwarfing mutations of DELLA proteins have been primarily responsible for the dramatic increases in harvest index of the 'green revolution'. Maize contains two genetic loci encoding DELLA proteins, dwarf plant8 (d8) and dwarf plant 9 (d9). The d8 gene and three of its dominant dwarfing alleles have been previously characterized at the molecular level. Almost 20 years after the initial description of the mutant, this investigation represents the first molecular characterization of d9 and its gibberellin-insensitive mutant, D9-1. We have molecularly, subcellularly and phenotypically characterized the gene products of five maize DELLA alleles in transgenic Arabidopsis. In dissecting the molecular differences in D9-1, a critical residue for normal DELLA function has been uncovered, corresponding to E600 of the D9 protein. The gibberellin-insensitive D9-1 was found to produce dwarfing and, notably, earlier flowering in Arabidopsis. Conversely, overexpression of the D9-1 allele delayed flowering in transgenic maize, while overexpression of the d9 allele led to earlier flowering. These results corroborate findings that DELLA proteins are at the crux of many plant developmental pathways and suggest differing mechanisms of flowering time control by DELLAs in maize and Arabidopsis.

  6. ["Notte della Taranta": new competences of the Disaster Manager Nurse].

    PubMed

    Zinnari, Elena M; Germinal, Francesco; Natalia, Barbara; Brienza, Nicola

    2014-01-01

    The disaster manager nurse is a new professional figure working in the field of rescue in environments struck by natural disasters, of land management, of contingency plans for the healthcare, of the setting up of Advanced Medical Posts and the management of events in which are foreseen a great influx of people. Analyzing the Advanced Medical Post set up during the "Notte della Taranta", a folk music festival that sees every years a large attendance, over 100.000 people we have predicted required human and logistic resources to health coverage of this event and to value criticality assessment of the scenario. A organized and precautionary response is basic to reduce consequences duty by the imbalance between required and available resources.

  7. The transcriptional regulator BBX24 impairs DELLA activity to promote shade avoidance in Arabidopsis thaliana.

    PubMed

    Crocco, Carlos D; Locascio, Antonella; Escudero, Cristian M; Alabadí, David; Blázquez, Miguel A; Botto, Javier F

    2015-02-06

    In response to canopy shade, plant vegetative structures elongate to gain access to light. However, the mechanism that allows a plastic transcriptional response to canopy shade light is not fully elucidated. Here we propose that the activity of PIF4, a key transcription factor in the shade signalling network, is modulated by the interplay between the BBX24 transcriptional regulator and DELLA proteins, which are negative regulators of the gibberellin (GA) signalling pathway. We show that GA-related targets are enriched among genes responsive to BBX24 under shade and that the shade-response defect in bbx24 mutants is rescued by a GA treatment that promotes DELLA degradation. BBX24 physically interacts with DELLA proteins and alleviates DELLA-mediated repression of PIF4 activity. The proposed molecular mechanism provides reversible regulation of the activity of a key transcription factor that may prove especially relevant under fluctuating light conditions.

  8. DELLA proteins modulate Arabidopsis defences induced in response to caterpillar herbivory

    PubMed Central

    Bede, Jacqueline C.

    2014-01-01

    Upon insect herbivory, many plant species change the direction of metabolic flux from growth into defence. Two key pathways modulating these processes are the gibberellin (GA)/DELLA pathway and the jasmonate pathway. In this study, the effect of caterpillar herbivory on plant-induced responses was compared between wild-type Arabidopsis thaliana (L.) Heynh. and quad-della mutants that have constitutively elevated GA responses. The labial saliva (LS) of caterpillars of the beet armyworm, Spodoptera exigua, is known to influence induced plant defence responses. To determine the role of this herbivore cue in determining metabolic shifts, plants were subject to herbivory by caterpillars with intact or impaired LS secretions. In both wild-type and quad-della plants, a jasmonate burst is an early response to caterpillar herbivory. Negative growth regulator DELLA proteins are required for the LS-mediated suppression of hormone levels. Jasmonate-dependent marker genes are induced in response to herbivory independently of LS, with the exception of AtPDF1.2 that showed LS-dependent expression in the quad-della mutant. Early expression of the salicylic acid (SA)-marker gene, AtPR1, was not affected by herbivory which also reflected SA hormone levels; however, this gene showed LS-dependent expression in the quad-della mutant. DELLA proteins may positively regulate glucosinolate levels and suppress laccase-like multicopper oxidase activity in response to herbivory. The present results show a link between DELLA proteins and early, induced plant defences in response to insect herbivory; in particular, these proteins are necessary for caterpillar LS-associated attenuation of defence hormones. PMID:24399173

  9. Plum Fruit Development Occurs via Gibberellin-Sensitive and -Insensitive DELLA Repressors.

    PubMed

    El-Sharkawy, Islam; Sherif, Sherif; Abdulla, Mahboob; Jayasankar, Subramanian

    2017-01-01

    Fruit growth depends on highly coordinated hormonal activities. The phytohormone gibberellin (GA) promotes growth by triggering degradation of the growth-repressing DELLA proteins; however, the extent to which such proteins contribute to GA-mediated fruit development remains to be clarified. Three new plum genes encoding DELLA proteins, PslGAI, PslRGL and PslRGA were isolated and functionally characterized. Analysis of expression profile during fruit development suggested that PslDELLA are transcriptionally regulated during flower and fruit ontogeny with potential positive regulation by GA and ethylene, depending on organ and developmental stage. PslGAI and PslRGL deduced proteins contain all domains present in typical DELLA proteins. However, PslRGA exhibited a degenerated DELLA domain and subsequently lacks in GID1-DELLA interaction property. PslDELLA-overexpression in WT Arabidopsis caused dramatic disruption in overall growth including root length, stem elongation, plant architecture, flower structure, fertility, and considerable retardation in development due to dramatic distortion in GA-metabolic pathway. GA treatment enhanced PslGAI/PslRGL interaction with PslGID1 receptors, causing protein destabilization and relief of growth-restraining effect. By contrast, PslRGA protein was not degraded by GA due to its inability to interact with PslGID1. Relative to other PslDELLA-mutants, PslRGA-plants displayed stronger constitutive repressive growth that was irreversible by GA application. The present results describe additional complexities in GA-signalling during plum fruit development, which may be particularly important to optimize successful reproductive growth.

  10. Arabidopsis DET1 represses photomorphogenesis in part by negatively regulating DELLA protein abundance in darkness.

    PubMed

    Li, Kunlun; Gao, Zhaoxu; He, Hang; Terzaghi, William; Fan, Liu-Min; Deng, Xing Wang; Chen, Haodong

    2015-04-01

    Arabidopsis De-etiolated 1 (DET1) is one of the key repressors that maintain the etiolated state of seedlings in darkness. The plant hormone gibberellic acid (GA) also participates in this process, and plants deficient in GA synthesis or signaling show a partially de-etiolated phenotype in darkness. However, how DET1 and the GA pathway work in concert in repressing photomorphogenesis remains largely unknown. In this study, we found that the abundance of DELLA proteins in det1-1 was increased in comparison with that in the wild-type plants. Mutation in DET1 changed the sensitivity of hypocotyl elongation of mutant seedlings to GA and paclobutrazol (PAC), an inhibitor of GA synthesis. However, we did not find obvious differences between det1-1 and wild-type plants with regard to the bioactive GA content or the GA signaling upstream of DELLAs. Genetic data showed that removal of several DELLA proteins suppressed the det1-1 mutant phenotype more obviously than GA treatment, indicating that DET1 can regulate DELLA proteins via some other mechanisms. In addition, a large-scale transcriptomic analysis revealed that DET1 and DELLAs play antagonistic roles in regulating expression of photosynthetic and cell elongation-related genes in etiolated seedlings. Taken together, our results show that DET1 represses photomorphogenesis in darkness in part by reducing the abundance of DELLA proteins. Copyright © 2015 The Author. Published by Elsevier Inc. All rights reserved.

  11. The DELLA-CONSTANS Transcription Factor Cascade Integrates Gibberellic Acid and Photoperiod Signaling to Regulate Flowering.

    PubMed

    Wang, Houping; Pan, Jinjing; Li, Yang; Lou, Dengji; Hu, Yanru; Yu, Diqiu

    2016-09-01

    Gibberellin (GA) and photoperiod pathways have recently been demonstrated to collaboratively modulate flowering under long days (LDs). However, the molecular mechanisms underlying this collaboration remain largely unclear. In this study, we found that GA-induced expression of FLOWERING LOCUS T (FT) under LDs was dependent on CONSTANS (CO), a critical transcription factor positively involved in photoperiod signaling. Mechanistic investigation revealed that DELLA proteins, a group of crucial repressors in GA signaling, physically interacted with CO. The DELLA-CO interactions repressed the transcriptional function of CO protein. Genetic analysis demonstrated that CO acts downstream of DELLA proteins to regulate flowering. Disruption of CO rescued the earlier flowering phenotype of the gai-t6 rga-t2 rgl1-1 rgl2-1 mutant (dellap), while a gain-of-function mutation in GA INSENSITIVE (GAI, a member of the DELLA gene) repressed the earlier flowering phenotype of CO-overexpressing plants. In addition, the accumulation of DELLA proteins and mRNAs was rhythmic, and REPRESSOR OF GA1-3 protein was noticeably decreased in the long-day afternoon, a time when CO protein is abundant. Collectively, these results demonstrate that the DELLA-CO cascade inhibits CO/FT-mediated flowering under LDs, which thus provide evidence to directly integrate GA and photoperiod signaling to synergistically modulate flowering under LDs. © 2016 American Society of Plant Biologists. All rights reserved.

  12. Inter- and intra-molecular interactions of Arabidopsis thaliana DELLA protein RGL1

    PubMed Central

    Sheerin, David J.; Buchanan, Jeremy; Kirk, Chris; Harvey, Dawn; Sun, Xiaolin; Spagnuolo, Julian; Li, Sheng; Liu, Tong; Woods, Virgil A.; Foster, Toshi; Jones, William T.; Rakonjac, Jasna

    2011-01-01

    The phytohormone gibberellin and the DELLA proteins act together to control key aspects of plant development. Gibberellin induces degradation of DELLA proteins by recruitment of an F-box protein using a molecular switch: a gibberellin-bound nuclear receptor interacts with the N-terminal domain of DELLA proteins, and this event primes the DELLA C-terminal domain for interaction with the F-box protein. However, the mechanism of signalling between the N- and C-terminal domains of DELLA proteins is unresolved. In the present study, we used in vivo and in vitro approaches to characterize di- and tri-partite interactions of the DELLA protein RGL1 (REPRESSOR OF GA1-3-LIKE 1) of Arabidopsis thaliana with the gibberellin receptor GID1A (GIBBERELLIC ACID-INSENSITIVE DWARF-1A) and the F-box protein SLY1 (SLEEPY1). Deuterium-exchange MS unequivocally showed that the entire N-terminal domain of RGL1 is disordered prior to interaction with the GID1A; furthermore, association/dissociation kinetics, determined by surface plasmon resonance, predicts a two-state conformational change of the RGL1 N-terminal domain upon interaction with GID1A. Additionally, competition assays with monoclonal antibodies revealed that contacts mediated by the short helix Asp-Glu-Leu-Leu of the hallmark DELLA motif are not essential for the GID1A–RGL1 N-terminal domain interaction. Finally, yeast two- and three-hybrid experiments determined that unabated communication between N- and C-terminal domains of RGL1 is required for recruitment of the F-box protein SLY1. PMID:21323638

  13. Mysteries of attraction: Giovanni Pico della Mirandola, astrology and desire.

    PubMed

    Rutkin, H Darrel

    2010-06-01

    Although in his later years Giovanni Pico della Mirandola (1463-1494) vehemently rejected astrology, he earlier used it in a variety of ways, but primarily to provide further evidence for positions to which he had arrived by other means. One such early use appears in his commentary on his friend Girolamo Benivieni's love poetry, the Canzone d'amore, of 1486-1487. In the passages discussed here, Pico presents an intensive Platonic natural philosophical analysis based on a deep astrologically informed understanding of human nature as he attempts to explain a perennial question, namely, why one person is attracted to a certain person (or people), and another to others. I will place this discussion of the mysteries of attraction and desire in historical perspective by tracing Pico's changing relationship to astrology during the course of his short but passionate life, and in historiographic perspective by revising Frances Yates's still influential views concerning Pico's contribution to Renaissance thought and his relationship with Marsilio Ficino.

  14. DELLA proteins regulate expression of a subset of AM symbiosis-induced genes in Medicago truncatula.

    PubMed

    Floss, Daniela S; Lévesque-Tremblay, Véronique; Park, Hee-Jin; Harrison, Maria J

    2016-01-01

    The majority of the vascular flowering plants form symbiotic associations with fungi from the phylum Glomeromycota through which both partners gain access to nutrients, either mineral nutrients in the case of the plant, or carbon, in the case of the fungus. (1) The association develops in the roots and requires substantial remodeling of the root cortical cells where branched fungal hyphae, called arbuscules, are housed in a new membrane-bound apoplastic compartment. (2) Nutrient exchange between the symbionts occurs over this interface and its development and maintenance is critical for symbiosis. Previously, we showed that DELLA proteins, which are well known as repressors of gibberellic acid signaling, also regulate development of AM symbiosis and are necessary to enable arbuscule development. (3) Furthermore, constitutive overexpression of a dominant DELLA protein (della1-Δ18) is sufficient to induce transcripts of several AM symbiosis-induced genes, even in the absence of the fungal symbiont. (4) Here we further extend this approach and identify AM symbiosis genes that respond transcriptionally to constitutive expression of a dominant DELLA protein and also genes that do respond to this treatment. Additionally, we demonstrate that DELLAs interact with REQUIRED FOR ARBUSCULE DEVELOPMENT 1 (RAD1) which further extends our knowledge of GRAS factor complexes that have the potential to regulate gene expression during AM symbiosis.

  15. Class I TCP-DELLA interactions in inflorescence shoot apex determine plant height.

    PubMed

    Davière, Jean-Michel; Wild, Michael; Regnault, Thomas; Baumberger, Nicolas; Eisler, Herfried; Genschik, Pascal; Achard, Patrick

    2014-08-18

    Regulation of plant height, one of the most important agronomic traits, is the focus of intensive research for improving crop performance. Stem elongation takes place as a result of repeated cell divisions and subsequent elongation of cells produced by apical and intercalary meristems. The gibberellin (GA) phytohormones have long been known to control stem and internodal elongation by stimulating the degradation of nuclear growth-repressing DELLA proteins; however, the mechanism allowing GA-responsive growth is only slowly emerging. Here, we show that DELLAs directly regulate the activity of the plant-specific class I TCP transcription factor family, key regulators of cell proliferation. Our results demonstrate that class I TCP factors directly bind the promoters of core cell-cycle genes in Arabidopsis inflorescence shoot apices while DELLAs block TCP function by binding to their DNA-recognition domain. GAs antagonize such repression by promoting DELLA destruction and therefore cause a concomitant accumulation of TCP factors on promoters of cell-cycle genes. Consistent with this model, the quadruple mutant tcp8 tcp14 tcp15 tcp22 exhibits severe dwarfism and reduced responsiveness to GA action. Altogether, we conclude that GA-regulated DELLA-TCP interactions in inflorescence shoot apex provide a novel mechanism to control plant height. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. DELLA-mediated gibberellin signalling regulates Nod factor signalling and rhizobial infection

    PubMed Central

    Fonouni-Farde, Camille; Tan, Sovanna; Baudin, Maël; Brault, Mathias; Wen, Jiangqi; Mysore, Kirankumar S.; Niebel, Andreas; Frugier, Florian; Diet, Anouck

    2016-01-01

    Legumes develop symbiotic interactions with rhizobial bacteria to form nitrogen-fixing nodules. Bacterial Nod factors (NFs) and plant regulatory pathways modulating NF signalling control rhizobial infections and nodulation efficiency. Here we show that gibberellin (GA) signalling mediated by DELLA proteins inhibits rhizobial infections and controls the NF induction of the infection marker ENOD11 in Medicago truncatula. Ectopic expression of a constitutively active DELLA protein in the epidermis is sufficient to promote ENOD11 expression in the absence of symbiotic signals. We show using heterologous systems that DELLA proteins can interact with the nodulation signalling pathway 2 (NSP2) and nuclear factor-YA1 (NF-YA1) transcription factors that are essential for the activation of NF responses. Furthermore, MtDELLA1 can bind the ERN1 (ERF required for nodulation 1) promoter and positively transactivate its expression. Overall, we propose that GA-dependent action of DELLA proteins may directly regulate the NSP1/NSP2 and NF-YA1 activation of ERN1 transcription to regulate rhizobial infections. PMID:27586842

  17. DELLA proteins regulate expression of a subset of AM symbiosis-induced genes in Medicago truncatula

    PubMed Central

    Floss, Daniela S.; Lévesque-Tremblay, Véronique; Park, Hee-Jin; Harrison, Maria J.

    2016-01-01

    ABSTRACT The majority of the vascular flowering plants form symbiotic associations with fungi from the phylum Glomeromycota through which both partners gain access to nutrients, either mineral nutrients in the case of the plant, or carbon, in the case of the fungus.1 The association develops in the roots and requires substantial remodeling of the root cortical cells where branched fungal hyphae, called arbuscules, are housed in a new membrane-bound apoplastic compartment.2 Nutrient exchange between the symbionts occurs over this interface and its development and maintenance is critical for symbiosis. Previously, we showed that DELLA proteins, which are well known as repressors of gibberellic acid signaling, also regulate development of AM symbiosis and are necessary to enable arbuscule development.3 Furthermore, constitutive overexpression of a dominant DELLA protein (della1-Δ18) is sufficient to induce transcripts of several AM symbiosis-induced genes, even in the absence of the fungal symbiont.4 Here we further extend this approach and identify AM symbiosis genes that respond transcriptionally to constitutive expression of a dominant DELLA protein and also genes that do respond to this treatment. Additionally, we demonstrate that DELLAs interact with REQUIRED FOR ARBUSCULE DEVELOPMENT 1 (RAD1) which further extends our knowledge of GRAS factor complexes that have the potential to regulate gene expression during AM symbiosis. PMID:26984507

  18. DELLA proteins are common components of symbiotic rhizobial and mycorrhizal signalling pathways

    PubMed Central

    Jin, Yue; Liu, Huan; Luo, Dexian; Yu, Nan; Dong, Wentao; Wang, Chao; Zhang, Xiaowei; Dai, Huiling; Yang, Jun; Wang, Ertao

    2016-01-01

    Legumes form symbiotic associations with either nitrogen-fixing bacteria or arbuscular mycorrhizal fungi. Formation of these two symbioses is regulated by a common set of signalling components that act downstream of recognition of rhizobia or mycorrhizae by host plants. Central to these pathways is the calcium and calmodulin-dependent protein kinase (CCaMK)–IPD3 complex which initiates nodule organogenesis following calcium oscillations in the host nucleus. However, downstream signalling events are not fully understood. Here we show that Medicago truncatula DELLA proteins, which are the central regulators of gibberellic acid signalling, positively regulate rhizobial symbiosis. Rhizobia colonization is impaired in della mutants and we provide evidence that DELLAs can promote CCaMK–IPD3 complex formation and increase the phosphorylation state of IPD3. DELLAs can also interact with NSP2–NSP1 and enhance the expression of Nod-factor-inducible genes in protoplasts. We show that DELLA is able to bridge a protein complex containing IPD3 and NSP2. Our results suggest a transcriptional framework for regulation of root nodule symbiosis. PMID:27514472

  19. Dynamic regulation of cortical microtubule organization through prefoldin-DELLA interaction.

    PubMed

    Locascio, Antonella; Blázquez, Miguel A; Alabadí, David

    2013-05-06

    Plant morphogenesis relies on specific patterns of cell division and expansion. It is well established that cortical microtubules influence the direction of cell expansion, but less is known about the molecular mechanisms that regulate microtubule arrangement. Here we show that the phytohormones gibberellins (GAs) regulate microtubule orientation through physical interaction between the nuclear-localized DELLA proteins and the prefoldin complex, a cochaperone required for tubulin folding. In the presence of GA, DELLA proteins are degraded, and the prefoldin complex stays in the cytoplasm and is functional. In the absence of GA, the prefoldin complex is localized to the nucleus, which severely compromises α/β-tubulin heterodimer availability, affecting microtubule organization. The physiological relevance of this molecular mechanism was confirmed by the observation that the daily rhythm of plant growth was accompanied by coordinated oscillation of DELLA accumulation, prefoldin subcellular localization, and cortical microtubule reorientation.

  20. JUB1 suppresses Pseudomonas syringae-induced defense responses through accumulation of DELLA proteins

    PubMed Central

    Shahnejat-Bushehri, Sara; Nobmann, Barbara; Devi Allu, Annapurna; Balazadeh, Salma

    2016-01-01

    ABSTRACT Phytohormones act in concert to coordinate plant growth and the response to environmental cues. Gibberellins (GAs) are growth-promoting hormones that recently emerged as modulators of plant immune signaling. By regulating the stability of DELLA proteins, GAs intersect with the signaling pathways of the classical primary defense hormones, salicylic acid (SA) and jasmonic acid (JA), thereby altering the final outcome of the immune response. DELLA proteins confer resistance to necrotrophic pathogens by potentiating JA signaling and raise the susceptibility to biotrophic pathogens by attenuating the SA pathway. Here, we show that JUB1, a core element of the GA - brassinosteroid (BR) - DELLA regulatory module, functions as a negative regulator of defense responses against Pseudomonas syringae pv. tomato DC3000 (Pst DC3000) and mediates the crosstalk between growth and immunity. PMID:27159137

  1. GA-DELLA pathway is involved in regulation of nitrogen deficiency-induced anthocyanin accumulation.

    PubMed

    Zhang, Yongqiang; Liu, Zhongjuan; Liu, Jianping; Lin, Sheng; Wang, Jianfeng; Lin, Wenxiong; Xu, Weifeng

    2017-04-01

    DELLA proteins positively regulate nitrogen deficiency-induced anthocyanin accumulation through directly interaction with PAP1 to enhance its transcriptional activity on anthocyanin biosynthetic gene expressions. Plants can survive a limiting nitrogen supply by undergoing adaptive responses, including induction of anthocyanin production. However, the detailed mechanism is still unclear. In this study, we found that this process was impaired and enhanced, respectively, by exogenous GA3 (an active form of GAs) and paclobutrazol (PAC, a specific GA biosynthesis inhibitor) in Arabidopsis seedlings. Consistently, the nitrogen deficiency-induced transcript levels of several key genes involved in anthocyanin biosynthesis, including F3'H, DFR, LDOX, and UF3GT, were decreased and enhanced by exogenous GA3 and PAC, respectively. Moreover, the nitrogen deficiency-induced anthocyanin accumulation and biosynthesis gene expressions were impaired in the loss-of-function mutant gai-t6/rga-t2/rgl1-1/rgl2-1/rgl3-1 (della) but enhanced in the GA-insensitive mutant gai, suggesting that DELLA proteins, known as repressors of GA signaling, are necessary for fully induction of nitrogen deficiency-driven anthocyanin biosynthesis. Using yeast two-hybrid (Y2H) assay, pull-down assay, and luciferase complementation assay, it was found that RGA, a DELLA of Arabidopsis, could strongly interact with PAP1, a known regulatory transcription factor positively involved in anthocyanin biosynthesis. Furthermore, transient expression assays indicated that RGA and GAI could enhance the transcriptional activities of PAP1 on its downstream genes, including F3'H and DFR. Taken together, this study suggests that DELLAs are necessary regulators for nitrogen deficiency-induced anthocyanin accumulation through interaction with PAP1 and enhancement of PAP1's transcriptional activity on its target genes. GA-DELLA-involved anthocyanin accumulation is important for plant adaptation to nitrogen deficiency.

  2. Plum Fruit Development Occurs via Gibberellin–Sensitive and –Insensitive DELLA Repressors

    PubMed Central

    El-Sharkawy, Islam; Sherif, Sherif; Abdulla, Mahboob

    2017-01-01

    Fruit growth depends on highly coordinated hormonal activities. The phytohormone gibberellin (GA) promotes growth by triggering degradation of the growth-repressing DELLA proteins; however, the extent to which such proteins contribute to GA-mediated fruit development remains to be clarified. Three new plum genes encoding DELLA proteins, PslGAI, PslRGL and PslRGA were isolated and functionally characterized. Analysis of expression profile during fruit development suggested that PslDELLA are transcriptionally regulated during flower and fruit ontogeny with potential positive regulation by GA and ethylene, depending on organ and developmental stage. PslGAI and PslRGL deduced proteins contain all domains present in typical DELLA proteins. However, PslRGA exhibited a degenerated DELLA domain and subsequently lacks in GID1–DELLA interaction property. PslDELLA–overexpression in WT Arabidopsis caused dramatic disruption in overall growth including root length, stem elongation, plant architecture, flower structure, fertility, and considerable retardation in development due to dramatic distortion in GA-metabolic pathway. GA treatment enhanced PslGAI/PslRGL interaction with PslGID1 receptors, causing protein destabilization and relief of growth-restraining effect. By contrast, PslRGA protein was not degraded by GA due to its inability to interact with PslGID1. Relative to other PslDELLA–mutants, PslRGA–plants displayed stronger constitutive repressive growth that was irreversible by GA application. The present results describe additional complexities in GA-signalling during plum fruit development, which may be particularly important to optimize successful reproductive growth. PMID:28076366

  3. Piero della Francesca's Sky in The Dream of Constantine

    NASA Astrophysics Data System (ADS)

    Valerio, V.

    2011-06-01

    The recent restoration of the frescoes by Piero della Francesca in the Church of San Francesco in Arezzo has made to appear on the background of the scene of Constantine's dream a number of stars. They are clearly painted with the intention to illustrate a sort of "natural" sky. In 2001 Anna Maria Maetzke recognized in a group of stars the constellation of the Ursa Minor, but so far no further study has been carried on to find any relation between the painted and the true sky. In this paper I show the existence of more constellations in the fresco, which are hardly detectable due to the mirror representation of the starry sky. Such a mirror image, as the Universe was seen from the outside, has a Greek origin and this kind of representation was introduced in Western Europe not only in celestial globes but also in star maps. This discovery leads to consider that Piero had at his disposal either a globe or a map which he reproduced on the fresco. My hypothesis is that a star map might be supplied to Piero by the astronomer Regiomontanus who was in Italy since 1461 following the Cardinal Bessarion in his journey from Wien to Rome. In 1463, Cardinal Bessarion was named papal legate to Venice and in July of the same year he leaved Rome together with Regiomontanus to reach Ferrara and Venice. The road to Venice crossed Umbria nearby Sansepolcro, Piero's birthplace not far from Arezzo. The trip took more than two weeks due to a stop before crossing the Apennines because the plague in Ferrara. Bessarion and Regiomontanus might have met Piero who was painting the cycle of frescoes in Arezzo and supplied him with a star map. Unfortunately, due to the lack of the horizon and any right line in the scene it is not possible to detect the latitude of the place corresponding to the painted sky.

  4. O-GlcNAcylation of master growth repressor DELLA by SECRET AGENT modulates multiple signaling pathways in Arabidopsis

    PubMed Central

    Zentella, Rodolfo; Hu, Jianhong; Hsieh, Wen-Ping; Matsumoto, Peter A.; Dawdy, Andrew; Barnhill, Benjamin; Oldenhof, Harriëtte; Hartweck, Lynn M.; Maitra, Sushmit; Thomas, Stephen G.; Cockrell, Shelley; Boyce, Michael; Shabanowitz, Jeffrey; Hunt, Donald F.; Olszewski, Neil E.; Sun, Tai-ping

    2016-01-01

    The DELLA family of transcription regulators functions as master growth repressors in plants by inhibiting phytohormone gibberellin (GA) signaling in response to developmental and environmental cues. DELLAs also play a central role in mediating cross-talk between GA and other signaling pathways via antagonistic direct interactions with key transcription factors. However, how these crucial protein–protein interactions can be dynamically regulated during plant development remains unclear. Here, we show that DELLAs are modified by the O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) SECRET AGENT (SEC) in Arabidopsis. O-GlcNAcylation of the DELLA protein REPRESSOR OF ga1-3 (RGA) inhibits RGA binding to four of its interactors—PHYTOCHROME-INTERACTING FACTOR3 (PIF3), PIF4, JASMONATE-ZIM DOMAIN1, and BRASSINAZOLE-RESISTANT1 (BZR1)—that are key regulators in light, jasmonate, and brassinosteroid signaling pathways, respectively. Consistent with this, the sec-null mutant displayed reduced responses to GA and brassinosteroid and showed decreased expression of several common target genes of DELLAs, BZR1, and PIFs. Our results reveal a direct role of OGT in repressing DELLA activity and indicate that O-GlcNAcylation of DELLAs provides a fine-tuning mechanism in coordinating multiple signaling activities during plant development. PMID:26773002

  5. O-GlcNAcylation of master growth repressor DELLA by SECRET AGENT modulates multiple signaling pathways in Arabidopsis.

    PubMed

    Zentella, Rodolfo; Hu, Jianhong; Hsieh, Wen-Ping; Matsumoto, Peter A; Dawdy, Andrew; Barnhill, Benjamin; Oldenhof, Harriëtte; Hartweck, Lynn M; Maitra, Sushmit; Thomas, Stephen G; Cockrell, Shelley; Boyce, Michael; Shabanowitz, Jeffrey; Hunt, Donald F; Olszewski, Neil E; Sun, Tai-Ping

    2016-01-15

    The DELLA family of transcription regulators functions as master growth repressors in plants by inhibiting phytohormone gibberellin (GA) signaling in response to developmental and environmental cues. DELLAs also play a central role in mediating cross-talk between GA and other signaling pathways via antagonistic direct interactions with key transcription factors. However, how these crucial protein-protein interactions can be dynamically regulated during plant development remains unclear. Here, we show that DELLAs are modified by the O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) SECRET AGENT (SEC) in Arabidopsis. O-GlcNAcylation of the DELLA protein REPRESSOR OF ga1-3 (RGA) inhibits RGA binding to four of its interactors-PHYTOCHROME-INTERACTING FACTOR3 (PIF3), PIF4, JASMONATE-ZIM DOMAIN1, and BRASSINAZOLE-RESISTANT1 (BZR1)-that are key regulators in light, jasmonate, and brassinosteroid signaling pathways, respectively. Consistent with this, the sec-null mutant displayed reduced responses to GA and brassinosteroid and showed decreased expression of several common target genes of DELLAs, BZR1, and PIFs. Our results reveal a direct role of OGT in repressing DELLA activity and indicate that O-GlcNAcylation of DELLAs provides a fine-tuning mechanism in coordinating multiple signaling activities during plant development.

  6. The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA

    PubMed Central

    Zentella, Rodolfo; Sui, Ning; Barnhill, Benjamin; Hsieh, Wen-Ping; Hu, Jianhong; Shabanowitz, Jeffrey; Boyce, Michael; Olszewski, Neil E.; Zhou, Pei; Hunt, Donald F.; Sun, Tai-ping

    2016-01-01

    Plant development requires coordination among complex signaling networks to enhance plant’s adaptation to changing environments. The transcription regulators DELLAs, originally identified as repressors of phytohormone gibberellin (GA) signaling, play a central role in integrating multiple signaling activities via direct protein interactions with key transcription factors. Here, we showed that DELLA was mono-O-fucosylated by a novel O-fucosyltransferase SPINDLY (SPY) in Arabidopsis thaliana. O-fucosylation activates DELLA by promoting its interaction with key regulators in brassinosteroid (BR)- and light-signaling pathways, including BRASSINAZOLE-RESISTANT1 (BZR1), PHYTOCHROME-INTERACTING-FACTOR3 (PIF3), and PIF4. Consistently, spy mutants displayed elevated responses to GA and BR, and increased expression of common target genes of DELLAs, BZR1 and PIFs. Our study revealed that SPY-dependent protein O-fucosylation plays a key role in regulating plant development. This finding has broader importance as SPY orthologs are conserved from prokaryotes to eukaryotes, suggesting that intracellular O-fucosylation may regulate a wide range of biological processes in diverse organisms. PMID:28244988

  7. How DELLAs contribute to control potassium uptake under conditions of potassium scarcity? Hypotheses and uncertainties.

    PubMed

    Oliferuk, Sonia; Ródenas, Reyes; Pérez, Adriana; Martinez, Vicente; Rubio, Francisco; Santa María, Guillermo E

    2017-08-17

    Maintenance of the inward transport of potassium (K) by roots is a critical step to ensure K-nutrition for all plant tissues. When plants are grown at low external K concentrations a strong enhancement of the activity of the AtHAK5 transporter takes place. In a recent work, we observed that the gai-1 mutant of Arabidopsis thaliana, which bears an altered function version of a DELLA regulatory protein, displays reduced accumulation of AtHAK5 transcripts and reduced uptake of Rubidium, an analog for K. In this Addendum we discuss some hypotheses and uncertainties regarding how DELLAs could contribute to the control of K uptake under those conditions. We advance the idea that, following K-restriction, there is a zone and tissue specific regulation of DELLAs by gibberellins through a pathway that likely involves ethylene. According to this model in the epidermis of non-apical zones, DELLAs repress transcription factors that promote AtHAK5 accumulation.

  8. The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA.

    PubMed

    Zentella, Rodolfo; Sui, Ning; Barnhill, Benjamin; Hsieh, Wen-Ping; Hu, Jianhong; Shabanowitz, Jeffrey; Boyce, Michael; Olszewski, Neil E; Zhou, Pei; Hunt, Donald F; Sun, Tai-Ping

    2017-05-01

    Plant development requires coordination among complex signaling networks to enhance the plant's adaptation to changing environments. DELLAs, transcription regulators originally identified as repressors of phytohormone gibberellin signaling, play a central role in integrating multiple signaling activities via direct protein interactions with key transcription factors. Here, we found that DELLA is mono-O-fucosylated by the novel O-fucosyltransferase SPINDLY (SPY) in Arabidopsis thaliana. O-fucosylation activates DELLA by promoting its interaction with key regulators in brassinosteroid- and light-signaling pathways, including BRASSINAZOLE-RESISTANT1 (BZR1), PHYTOCHROME-INTERACTING-FACTOR3 (PIF3) and PIF4. Moreover, spy mutants displayed elevated responses to gibberellin and brassinosteroid, and increased expression of common target genes of DELLAs, BZR1 and PIFs. Our study revealed that SPY-dependent protein O-fucosylation plays a key role in regulating plant development. This finding may have broader importance because SPY orthologs are conserved in prokaryotes and eukaryotes, thus suggesting that intracellular O-fucosylation may regulate a wide range of biological processes in diverse organisms.

  9. [Adalberto Pazzini and the origins of the Istituto di Storia della Medicina].

    PubMed

    Conforti, Maria

    2006-01-01

    The first part of the paper deals with the Italian tradition of medical history in the 1930s, when Adalberto Pazzini became the most successful medical historian in Italy. Its second part deals with the founding and renovation (1938 and 1954 respectively) of the Istituto di Storia della Medicina at Rome University, with a description of the innovative--and largely utopian--planning of the Library and of the Museum and didactic collections by Pazzini.

  10. The DELLA Protein SLR1 Integrates and Amplifies Salicylic Acid- and Jasmonic Acid-Dependent Innate Immunity in Rice1

    PubMed Central

    De Vleesschauwer, David; Seifi, Hamed Soren; Haeck, Ashley; Huu, Son Nguyen; Demeestere, Kristof

    2016-01-01

    Gibberellins are a class of tetracyclic plant hormones that are well known to promote plant growth by inducing the degradation of a class of nuclear growth-repressing proteins, called DELLAs. In recent years, GA and DELLAs are also increasingly implicated in plant responses to pathogen attack, although our understanding of the underlying mechanisms is still limited, especially in monocotyledonous crop plants. Aiming to further decipher the molecular underpinnings of GA- and DELLA-modulated plant immunity, we studied the dynamics and impact of GA and DELLA during infection of the model crop rice (Oryza sativa) with four different pathogens exhibiting distinct lifestyles and infection strategies. Opposite to previous findings in Arabidopsis (Arabidopsis thaliana), our findings reveal a prominent role of the DELLA protein Slender Rice1 (SLR1) in the resistance toward (hemi)biotrophic but not necrotrophic rice pathogens. Moreover, contrary to the differential effect of DELLA on the archetypal defense hormones salicylic acid (SA) and jasmonic acid (JA) in Arabidopsis, we demonstrate that the resistance-promoting effect of SLR1 is due at least in part to its ability to boost both SA- and JA-mediated rice defenses. In a reciprocal manner, we found JA and SA treatment to interfere with GA metabolism and stabilize SLR1. Together, these findings favor a model whereby SLR1 acts as a positive regulator of hemibiotroph resistance in rice by integrating and amplifying SA- and JA-dependent defense signaling. Our results highlight the differences in hormone defense networking between rice and Arabidopsis and underscore the importance of GA and DELLA in molding disease outcomes. PMID:26829979

  11. The DELLA Protein SLR1 Integrates and Amplifies Salicylic Acid- and Jasmonic Acid-Dependent Innate Immunity in Rice.

    PubMed

    De Vleesschauwer, David; Seifi, Hamed Soren; Filipe, Osvaldo; Haeck, Ashley; Huu, Son Nguyen; Demeestere, Kristof; Höfte, Monica

    2016-03-01

    Gibberellins are a class of tetracyclic plant hormones that are well known to promote plant growth by inducing the degradation of a class of nuclear growth-repressing proteins, called DELLAs. In recent years, GA and DELLAs are also increasingly implicated in plant responses to pathogen attack, although our understanding of the underlying mechanisms is still limited, especially in monocotyledonous crop plants. Aiming to further decipher the molecular underpinnings of GA- and DELLA-modulated plant immunity, we studied the dynamics and impact of GA and DELLA during infection of the model crop rice (Oryza sativa) with four different pathogens exhibiting distinct lifestyles and infection strategies. Opposite to previous findings in Arabidopsis (Arabidopsis thaliana), our findings reveal a prominent role of the DELLA protein Slender Rice1 (SLR1) in the resistance toward (hemi)biotrophic but not necrotrophic rice pathogens. Moreover, contrary to the differential effect of DELLA on the archetypal defense hormones salicylic acid (SA) and jasmonic acid (JA) in Arabidopsis, we demonstrate that the resistance-promoting effect of SLR1 is due at least in part to its ability to boost both SA- and JA-mediated rice defenses. In a reciprocal manner, we found JA and SA treatment to interfere with GA metabolism and stabilize SLR1. Together, these findings favor a model whereby SLR1 acts as a positive regulator of hemibiotroph resistance in rice by integrating and amplifying SA- and JA-dependent defense signaling. Our results highlight the differences in hormone defense networking between rice and Arabidopsis and underscore the importance of GA and DELLA in molding disease outcomes. © 2016 American Society of Plant Biologists. All Rights Reserved.

  12. Overexpression of RoDELLA impacts the height, branching, and flowering behaviour of Pelargonium × domesticum transgenic plants.

    PubMed

    Hamama, L; Naouar, A; Gala, R; Voisine, L; Pierre, S; Jeauffre, J; Cesbron, D; Leplat, F; Foucher, F; Dorion, N; Hibrand-Saint Oyant, L

    2012-11-01

    KEY MESSAGE : We reported the cloning of a rose DELLA gene. We obtained transgenic Pelargonium lines overexpressing this gene which presented several phenotypes in plant growth, root growth, flowering time and number of inflorescences. Control of development is an important issue for production of ornamental plant. The plant growth regulator, gibberellins (GAs), plays a pivotal role in regulating plant growth and development. DELLA proteins are nuclear negative regulator of GA signalling. Our objective was to study the role of GA in the plant architecture and in the blooming of ornamentals. We cloned a rose DELLA homologous gene, RoDELLA, and studied its function by genetic transformation of pelargonium. Several transgenic pelargonium (Pelargonium × domesticum 'Autum Haze') lines were produced that ectopically expressed RoDELLA under the control of the 35S promoter. These transgenic plants exhibited a range of phenotypes which could be related to the reduction in GA response. Most of transgenic plants showed reduced growth associated to an increase of the node and branch number. Moreover, overexpression of RoDELLA blocked or delayed flowering in transgenic pelargonium and exhibited defects in the root formation. We demonstrated that pelargonium could be used to validate ornamental gene as the rose DELLA gene. RoDELLA overexpression modified many aspects of plant developmental pathways, as the plant growth, the transition of vegetative to floral stage and the ability of rooting.

  13. The altarpieces of Della Robbia atelier in Marche region: investigations on technology and provenance

    NASA Astrophysics Data System (ADS)

    Amadori, M. L.; Barcelli, S.; Barcaioni, S.; Bouquillon, A.; Padeletti, G.; Pallante, P.

    2013-12-01

    Dissemination of Della Robbia glazed terracotta in the Marche (Italy) region started from the third decade of the 16th century. Numerous altarpieces, some of which no longer exist, document this artistic production. The protagonists of this diffusion phase were two of Andrea Della Robbia's sons, Marco (Fra Mattia) and Francesco (Fra Ambrogio). This paper shows the results of the scientific investigations carried out on constitutive materials of different altarpieces located in South Marche belonging to the Fra Mattia's production: the Coronation of Virgin between Saints Rocco, Sebastian, Peter martyr and Antonio abbot, dated back to 1527-1530, located in the collegiate church of S. Maria Assunta in Montecassiano; the Annunciation, dated back to 1520, placed in the church of S. Maria del Soccorso in Arcevia; the fragmentary Crowned Madonna and saints altarpiece, probably realized after 1531, today preserved in Civic Museum of Ripatransone. The first altarpiece was made in Montecassiano using two different assembling or production techniques: the external part of the lunette and the pillar strips are made of glazed polychrome terracotta, while the altar step and the internal part are an interesting and uncommon example of polychrome painted terracotta. The provenance of the glazed Arcevia altarpiece is not clear yet: some historians hypothesize a local manufacture of Fra Mattia and some others a Roman or Florentine production. The remaining parts of Ripatransone altarpiece are partially glazed and partially not coated perhaps because they were unfinished and not yet painted. Clay body samples collected from the above mentioned altarpieces were investigated using different analytical techniques (OM, XRD, XRF, PIXE) to point out differences in chemical and mineralogical composition and to determine if the altarpieces were made by using local raw clay materials or other clays from Tuscany or Campania as in the Della Robbia previous production. A comparison has also been

  14. The Renaissance and the universal surgeon: Giovanni Andrea Della Croce, a master of traumatology.

    PubMed

    Di Matteo, Berardo; Tarabella, Vittorio; Filardo, Giuseppe; Viganò, Anna; Tomba, Patrizia; Marcacci, Maurilio

    2013-12-01

    All the medical knowledge of all time in one book, the universal and perfect manual for the Renaissance surgeon, and the man who wrote it. This paper depicts the life and works of Giovanni Andrea della Croce, a 16th Century physician and surgeon, who, endowed with true spirit of Renaissance humanism, wanted to teach and share all his medical knowledge through his opus magnum, titled "Universal Surgery Complete with All the Relevant Parts for the Optimum Surgeon". An extraordinary book which truly represents a defining moment and a founding stone for traumatology, written by a lesser known historical personality, but nonetheless the Renaissance Master of Traumatology.

  15. Down-regulation of DELLA genes is not essential for germination of tomato, soybean, and Arabidopsis seeds.

    PubMed

    Bassel, George W; Zielinska, Elzbieta; Mullen, Robert T; Bewley, J Derek

    2004-09-01

    The relationship between expression of a negative regulator of GA signal transduction (RGL2) belonging to the DELLA gene family and repression of Arabidopsis seed germination has been studied (Lee S, Cheng H, King KE, Wang W, He Y, Hussain A, Lo J, Harberd NP, Peng J [2002] Genes and Development 16: 646-658). There is one DELLA gene (LeGAI) present in tomato (Lycopersicon esculentum Mill.), which is expressed in both vegetative and reproductive tissues. During germination of wild-type tomato seed, there was no decline in the expression of LeGAI in either the embryo or the endosperm. Rather, LeGAI transcripts increased in these tissues following imbibition and remained high during and following germination. A similar increase in LeGAI transcripts occurred in the endosperm and embryo of GA-treated gib-1 mutant seed during and following germination. Likewise in soybean (Glycine max) seed, there was no decline in the expression of two DELLA genes in the radicle before or after germination. Upon reexamination of RGL2 in Arabidopsis seeds, a decline in its expression was noted but only after radicle emergence, i.e. after germination had been completed. Taken together, these data are consistent with GA-induced down-regulation of DELLA genes not being a prerequisite for germination of tomato, soybean, and Arabidopsis seeds.

  16. Down-Regulation of DELLA Genes Is Not Essential for Germination of Tomato, Soybean, and Arabidopsis Seeds1

    PubMed Central

    Bassel, George W.; Zielinska, Elzbieta; Mullen, Robert T.; Bewley, J. Derek

    2004-01-01

    The relationship between expression of a negative regulator of GA signal transduction (RGL2) belonging to the DELLA gene family and repression of Arabidopsis seed germination has been studied (Lee S, Cheng H, King KE, Wang W, He Y, Hussain A, Lo J, Harberd NP, Peng J [2002] Genes and Development 16: 646–658). There is one DELLA gene (LeGAI) present in tomato (Lycopersicon esculentum Mill.), which is expressed in both vegetative and reproductive tissues. During germination of wild-type tomato seed, there was no decline in the expression of LeGAI in either the embryo or the endosperm. Rather, LeGAI transcripts increased in these tissues following imbibition and remained high during and following germination. A similar increase in LeGAI transcripts occurred in the endosperm and embryo of GA-treated gib-1 mutant seed during and following germination. Likewise in soybean (Glycine max) seed, there was no decline in the expression of two DELLA genes in the radicle before or after germination. Upon reexamination of RGL2 in Arabidopsis seeds, a decline in its expression was noted but only after radicle emergence, i.e. after germination had been completed. Taken together, these data are consistent with GA-induced down-regulation of DELLA genes not being a prerequisite for germination of tomato, soybean, and Arabidopsis seeds. PMID:15347801

  17. TMV-Cg Coat Protein stabilizes DELLA proteins and in turn negatively modulates salicylic acid-mediated defense pathway during Arabidopsis thaliana viral infection

    PubMed Central

    2014-01-01

    Background Plant viral infections disturb defense regulatory networks during tissue invasion. Emerging evidence demonstrates that a significant proportion of these alterations are mediated by hormone imbalances. Although the DELLA proteins have been reported to be central players in hormone cross-talk, their role in the modulation of hormone signaling during virus infections remains unknown. Results This work revealed that TMV-Cg coat protein (CgCP) suppresses the salicylic acid (SA) signaling pathway without altering defense hormone SA or jasmonic acid (JA) levels in Arabidopsis thaliana. Furthermore, it was observed that the expression of CgCP reduces plant growth and delays the timing of floral transition. Quantitative RT-qPCR analysis of DELLA target genes showed that CgCP alters relative expression of several target genes, indicating that the DELLA proteins mediate transcriptional changes produced by CgCP expression. Analyses by fluorescence confocal microscopy showed that CgCP stabilizes DELLA proteins accumulation in the presence of gibberellic acid (GA) and that the DELLA proteins are also stabilized during TMV-Cg virus infections. Moreover, DELLA proteins negatively modulated defense transcript profiles during TMV-Cg infection. As a result, TMV-Cg accumulation was significantly reduced in the quadruple-DELLA mutant Arabidopsis plants compared to wild type plants. Conclusions Taken together, these results demonstrate that CgCP negatively regulates the salicylic acid-mediated defense pathway by stabilizing the DELLA proteins during Arabidopsis thaliana viral infection, suggesting that CgCP alters the stability of DELLAs as a mechanism of negative modulation of antiviral defense responses. PMID:25084837

  18. TMV-Cg Coat Protein stabilizes DELLA proteins and in turn negatively modulates salicylic acid-mediated defense pathway during Arabidopsis thaliana viral infection.

    PubMed

    Rodriguez, Maria Cecilia; Conti, Gabriela; Zavallo, Diego; Manacorda, Carlos Augusto; Asurmendi, Sebastian

    2014-08-03

    Plant viral infections disturb defense regulatory networks during tissue invasion. Emerging evidence demonstrates that a significant proportion of these alterations are mediated by hormone imbalances. Although the DELLA proteins have been reported to be central players in hormone cross-talk, their role in the modulation of hormone signaling during virus infections remains unknown. This work revealed that TMV-Cg coat protein (CgCP) suppresses the salicylic acid (SA) signaling pathway without altering defense hormone SA or jasmonic acid (JA) levels in Arabidopsis thaliana. Furthermore, it was observed that the expression of CgCP reduces plant growth and delays the timing of floral transition. Quantitative RT-qPCR analysis of DELLA target genes showed that CgCP alters relative expression of several target genes, indicating that the DELLA proteins mediate transcriptional changes produced by CgCP expression. Analyses by fluorescence confocal microscopy showed that CgCP stabilizes DELLA proteins accumulation in the presence of gibberellic acid (GA) and that the DELLA proteins are also stabilized during TMV-Cg virus infections. Moreover, DELLA proteins negatively modulated defense transcript profiles during TMV-Cg infection. As a result, TMV-Cg accumulation was significantly reduced in the quadruple-DELLA mutant Arabidopsis plants compared to wild type plants. Taken together, these results demonstrate that CgCP negatively regulates the salicylic acid-mediated defense pathway by stabilizing the DELLA proteins during Arabidopsis thaliana viral infection, suggesting that CgCP alters the stability of DELLAs as a mechanism of negative modulation of antiviral defense responses.

  19. Brassica napus DS-3, encoding a DELLA protein, negatively regulates stem elongation through gibberellin signaling pathway.

    PubMed

    Zhao, Bo; Li, Haitao; Li, Juanjuan; Wang, Bo; Dai, Cheng; Wang, Jing; Liu, Kede

    2017-04-01

    Identification and characterization of a semi-dwarfing gene ds-3 encoding a mutant DELLA protein regulating plant height through gibberellin signaling pathway. Lodging is one of the most important factors causing severe yield loss in oilseed rape. Utilization of semi-dwarf varieties has been proved the most effective way to increase lodging resistance and yield in many crops. To develop semi-dwarf germplasm in oilseed rape, we identified a semi-dwarf mutant ds-3 which showed a reduced response to phytohormones gibberellins (GAs). Genetic analysis indicated the dwarfism was controlled by a single semi-dominant gene, ds-3. The DS-3 gene was mapped to a genomic region on chromosome C07, which is syntenic to the region of a previously identified semi-dwarf gene ds-1 (BnaA06.RGA). In this region, DS-3 (BnaC07.RGA) gene was identified to encode a DELLA protein that functions as a repressor in GA signaling pathway. A substitution of proline to leucine was identified in ds-3 in the conserved VHYNP motif, which is essential for GA-dependent interaction between gibberellin receptor GID1 and DELLA proteins. Segregation analysis in the F2 population derived from the cross between ds-1 and ds-3 demonstrated that BnaA06.RGA displayed a stronger effect on plant height than BnaC07.RGA, indicating that different RGA genes may play different roles in stem elongation. In addition to BnaA06.RGA and BnaC07.RGA, two more RGA genes (BnaA09.RGA and BnaC09.RGA) were identified in the Brassica napus (B. napus) genome. Reverse-transcription polymerase chain reaction (RT-PCR) and yeast two-hybrid (Y2H) assays suggest that both BnaA09.RGA and BnaC09.RGA are transcribed in leaves and stems and can mediate GA signaling in vivo. These genes represent potential targets for screening ideal semi-dwarfing alleles for oilseed rape breeding.

  20. Lungo le vie di pellegrinaggio: la lezione astronomica di Gerberto a San Michele della Chiusa

    NASA Astrophysics Data System (ADS)

    Paladino, Laura C.

    A pilgrim on the trails of the Earth: that's how Gerbertus appears to us in the years preceding his pontificate as well in those, brief and intense, in which he was Pope. An ardent pilgrim of faith moved at the same time by vast intellectual interests that allowed him to come into contact with the most important schools of the time, of any cultural tradition; a pilgrim full of love, willing to transmit the enormous heritage of faith and knowledge of which he was custodian. The presence of the illustrious Benedictine is not explicitly documented in the Abbey of San Michele della Chiusa, but the signs of its cultural and ideological influence are evident both in historical memory as in the artistical vestiges of the Sacra: we investigate here, this presence, authoritative, original and versatile, to outline another aspect, still little investigated, of the lesson of Gerbert, monk, scientist, teacher and pastor.

  1. La meridiana di Egnazio Danti nella Torre dei Venti in Vaticano: un'icona della riforma Gregoriana del calendario

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2014-05-01

    La Torre dei Venti domina l’angolo Sud Ovest del cortile della Pigna (nell'area dei Musei Vaticani), ed è inclusa negli ambienti dell'Archivio Segreto Vaticano. Non è aperta al pubblico, ma è universalmente nota per la fama che da oltre quattrocento anni la circonda, legata alle vicende della riforma Gregoriana del calendario. La meridiana tracciata da padre Egnazio Danti (1536-1586) nella torre dei Venti, fu visitata anche da Gregorio XIII, probabilmente il 21 marzo 1581 come suppone il padre Stein, per convincersi dell'anticipo ormai arrivato a dieci giorni dell'equinozio di primavera sulla data che il concilio di Nicea aveva fissato al 21 marzo per il computo pasquale. La ricognizione astrometrica del febbraio-marzo 2009 fatta dall'autore viene qui presentata.

  2. [Malattia di Marchiafava-Bignami con coinvolgimento della corteccia frontale e insorgenza tardiva di sintomi psichiatrici resistenti: un caso clinico].

    PubMed

    Gramaglia, Carla; Feggi, Alessandro; Vecchi, Camilla; Di Marco, Sarah; Venesia, Alessandra; Delicato, Claudia; Chieppa, Nunzia; De Marchi, Fabiola; Cantello, Roberto; Zeppegno, Patrizia

    2016-01-01

    RIASSUNTO. Scopo. Descrivere il management di un paziente con malattia di Marchiafava-Bignami (MBD) associata a lesioni frontali corticali, senza sintomi specifici al primo accesso in Pronto Soccorso, e insorgenza tardiva di sintomi psichiatrici atipici. Metodi. Descriviamo il caso di un paziente di 44 anni con storia di abuso cronico di alcol, a cui è stata diagnosticata la MBD. Risultati. La risonanza magnetica ha evidenziato lesioni nello splenio e corpo del corpo calloso e lesioni bilaterali della corteccia frontale. Il paziente ha sviluppato sintomi psichiatrici atipici a insorgenza tardiva, che sono risultati essere resistenti alle terapie farmacologiche impostate. Discussione. Il caso che descriviamo sembra supportare le attuali, ma ancora scarse evidenze che descrivono il coinvolgimento corticale nella MBD, suggerendone l'associazione con una prognosi peggiore. I sintomi psichiatrici possono risultare difficili da trattare a causa della resistenza alle terapie. Conclusione. Il coinvolgimento di psichiatri, radiologi e neurologi secondo un approccio di consultazione-liaison si è dimostrato di fondamentale importanza per la diagnosi e l'impostazione della terapia adeguata al paziente.

  3. Multielemental analysis of tissues from Cangrande della Scala, Prince of Verona, in the 14th century.

    PubMed

    Apostoli, Pietro; De Palma, Giuseppe; Catalani, Simona; Bortolotti, Federica; Tagliaro, Franco

    2009-01-01

    Cangrande della Scala, Prince of Verona (Italy), died suddenly shortly after his triumph in the battle of Treviso (July 18, 1329). Thus, in the frame of a multidisciplinary paleo-pathological study, we carried out a multielemental analysis on the Prince's tissue specimens, including hair, liver, muscle, and bone, in order to characterize a multitissue profile of metallic elements in a nobleman of the 14th century. Biological specimens were analyzed by inductively coupled plasma-mass spectrometry. We were able to rule out arsenic poisoning as the primary cause of death. High levels of gold and silver in both hair and liver samples were probably due to prolonged contact of the mummy with precious metals in the funeral garments. High lead concentrations in both liver and bone tissue can be traced back to the ingestion of contaminated food and alcoholic beverages. Most of the essential elements were in the normal range of values for contemporary living people. The low arsenic and chromium levels in the Prince's tissues as compared to modern people would be suggestive of raised concentrations of both the elements in the present era, which are likely due to industrial pollution.

  4. A Gibberellin-Mediated DELLA-NAC Signaling Cascade Regulates Cellulose Synthesis in Rice[OPEN

    PubMed Central

    Huang, Debao; Wang, Shaogan; Zhang, Baocai; Shang-Guan, Keke; Shi, Yanyun; Zhang, Dongmei; Liu, Xiangling; Wu, Kun; Xu, Zuopeng; Fu, Xiangdong; Zhou, Yihua

    2015-01-01

    Cellulose, which can be converted into numerous industrial products, has important impacts on the global economy. It has long been known that cellulose synthesis in plants is tightly regulated by various phytohormones. However, the underlying mechanism of cellulose synthesis regulation remains elusive. Here, we show that in rice (Oryza sativa), gibberellin (GA) signals promote cellulose synthesis by relieving the interaction between SLENDER RICE1 (SLR1), a DELLA repressor of GA signaling, and NACs, the top-layer transcription factors for secondary wall formation. Mutations in GA-related genes and physiological treatments altered the transcription of CELLULOSE SYNTHASE genes (CESAs) and the cellulose level. Multiple experiments demonstrated that transcription factors NAC29/31 and MYB61 are CESA regulators in rice; NAC29/31 directly regulates MYB61, which in turn activates CESA expression. This hierarchical regulation pathway is blocked by SLR1-NAC29/31 interactions. Based on the results of anatomical analysis and GA content examination in developing rice internodes, this signaling cascade was found to be modulated by varied endogenous GA levels and to be required for internode development. Genetic and gene expression analyses were further performed in Arabidopsis thaliana GA-related mutants. Altogether, our findings reveal a conserved mechanism by which GA regulates secondary wall cellulose synthesis in land plants and provide a strategy for manipulating cellulose production and plant growth. PMID:26002868

  5. Chromosomenindividualität or Entmischung? The debate between Paolo Della Valle and Edmund B. Wilson.

    PubMed

    Volpone, Alessandro

    2015-01-01

    At the beginning of the twentieth century, the Italian cytologist Paolo Della Valle developed a theory of instable chromosomes (teoria dei cromosomi labili). He radically criticized the so-called Sutton-Boveri hypothesis (Martins and Martins, Genetics and Molecular Biology, 22:261-271, 1999), focusing on numerical constancy in the species and individuality. On the basis of bibliographical review and personal observations, he maintained that the chromosomes were neither stable bodies, nor permanent structures, but transitory cellular materials, resulting from the periodical rearrangement of the chromatin during the cell division. German and English-speaking biologists reacted. The paper shows some content of the argumentations used by Thomas H. Montgomery and especially Edmund B. Wilson. The discussion was characterized by the same data which is interpretedby different scholars in different ways. And the point is that no one of them had the decisive test to demonstrate his own point of view. Wilson simply invoked on his behalf a certain 'common sense', defending at least a 'high degree of constancy'. The debate waned along with the reception of Morgan's chromosome theory of heredity, but only the advent of molecular biology definitively stated the nature of chromosomes as permanent structures of the cell.

  6. The Book of the Sick of Santa Maria della Morte in Bologna and the Medical Organization of a Hospital in the Sixteenth-Century.

    PubMed

    Savoia, Paolo

    2016-01-01

    In 2012 a manuscript was rediscovered in the Biblioteca dell'Archiginnasio of Bologna, titled Libro degli infermi dell'Arciconfraternita di S. Maria della Morte. It is the record of incoming patients of one for the main hospitals of the city, devoted exclusively to the sick poor and not just to the poor, called Santa Maria della Morte, compiled by a young student assistant (astante) for the period 1558-1564. I publish here a transcription of a portion of this Libro pertaining to the year 1560. My introduction situates the manuscript within the context of the history of early modern Italian hospitals, describes the organization of the hospital of Santa Maria della Morte based on archival sources of the period, and finally highlights the connections between surgical and anatomical education and the internal organization of the hospital.

  7. The angiosperm gibberellin-GID1-DELLA growth regulatory mechanism: how an "inhibitor of an inhibitor" enables flexible response to fluctuating environments.

    PubMed

    Harberd, Nicholas P; Belfield, Eric; Yasumura, Yuki

    2009-05-01

    The phytohormone gibberellin (GA) has long been known to regulate the growth, development, and life cycle progression of flowering plants. However, the molecular GA-GID1-DELLA mechanism that enables plants to respond to GA has only recently been discovered. In addition, studies published in the last few years have highlighted previously unsuspected roles for the GA-GID1-DELLA mechanism in regulating growth response to environmental variables. Here, we review these advances within a general plant biology context and speculate on the answers to some remaining questions. We also discuss the hypothesis that the GA-GID1-DELLA mechanism enables flowering plants to maintain transient growth arrest, giving them the flexibility to survive periods of adversity.

  8. The wheat mutant DELLA-encoding gene (Rht-B1c) affects plant photosynthetic responses to cadmium stress.

    PubMed

    Dobrikova, Anelia G; Yotsova, Ekaterina K; Börner, Andreas; Landjeva, Svetlana P; Apostolova, Emilia L

    2017-05-01

    Тhe sensitivity to cadmium (Cd) stress of two near-isogenic wheat lines with differences at the Rht-B1 locus, Rht-B1a (tall wild type, encoding DELLA proteins) and Rht-B1c (dwarf mutant, encoding modified DELLA proteins), was investigated. The effects of 100 μM CdCl2 on plant growth, pigment content and functional activity of the photosynthetic apparatus of wheat seedlings grown on a nutrient solution were evaluated through a combination of PAM chlorophyll fluorescence, oxygen evolution, oxidation-reduction kinetics of P700 and 77 K fluorescence. The results showed that the wheat mutant (Rht-B1c) was more tolerant to Cd stress compared to the wild type (Rht-B1a), as evidenced by the lower reductions in plant growth and pigment content, lower inhibition of photosystem I (PSI) and photosystem II (PSII) photochemistry and of the oxygen evolution measured with Clark-type and Joliot-type electrodes. Furthermore, the enhanced Cd tolerance was accompanied by increased Cd accumulation within mutant plant tissues. The molecular mechanisms through which the Rht-B1c mutation improves plant tolerance to Cd stress involve structural alterations in the mutant photosynthetic membranes leading to better protection of the Mn cluster of oxygen-evolving complex and increased capacity for PSI cyclic electron transport, protecting photochemical activity of the photosynthetic apparatus under stress. This study suggests a role for the Rht-B1c-encoded DELLA proteins in protective mechanisms and tolerance of the photosynthetic apparatus in wheat plants exposed to heavy metals stress. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  9. Geochemical and mineralogical fingerprints to distinguish the exploited ferruginous mineralisations of Grotta della Monaca (Calabria, Italy)

    NASA Astrophysics Data System (ADS)

    Dimuccio, Luca Antonio; Rodrigues, Nelson; Larocca, Felice; Pratas, João; Amado, Ana Margarida; de Carvalho, Luís A. E. Batista

    2017-02-01

    This study examines the geochemical and mineralogical variations in the ferruginous mineralisations that crop out within Grotta della Monaca, which is considered to be the most striking and best known example of a prehistoric iron mine-cave from the southern Apennines (Calabria, Italy). Previous archaeological research identified three local and distinct ancient exploitation phases of these ferruginous mineralisations: (1) an Upper Palaeolithic phase; (2) a Late Neolithic phase; and (3) a post-Medieval phase. These materials, which have various forms of complex mineralogical admixtures and range in colour from yellow-orange to red and darker brown shades, mainly consist of iron oxides/hydroxides (essentially goethite and lepidocrocite), which are often mixed with subordinate and variable amounts of other matrix components (carbonates, sulphates, arsenates, silicates and organic matter). Such ferruginous mineralisations generally correspond to geochemically heterogeneous massive dyke/vein/mammillary/stratiform facies that are exposed within the local caves along open fractures and inclined bedding planes and that partially cover cave wall niches/notches/pockets and ceiling cupolas/holes. Selected samples/sub-samples are analysed through a multi-technique approach with a handheld portable X-ray Fluorescence, X-ray Diffraction, micro-Raman and Fourier Transform Infrared spectroscope (both conventional and attenuated total reflection), which is combined with subsequent multivariate statistical analysis of the elemental concentration data. The geochemical and mineralogical results are used to individualise similar compositional clusters. As expected, the identified groups, each of which has very specific geochemical-mineralogical "fingerprints" and spatial distributions, enable us to identify the sampled ferruginous mineralisations. These specific mineral resources can be compared to similar raw materials that are found in other neighbouring archaeological sites, with

  10. The Megalithic Complex of the ``Preta 'ru Mulacchio'' on the Monte della Stella

    NASA Astrophysics Data System (ADS)

    Polcaro, V. F.; Ienna, D.

    2009-08-01

    The Monte della Stella is a 1131~m high mountain, belonging to the range separating the Alento Valley from the Tyrrhenian Sea, south of the city of Agropoli in Italy. At 1030~m over the sea-level, a large, isolated outcrop of the bedrock is present. This rock is well known to local people and called the ``Preta 'ru Mulacchio'', expression meaning in the local dialect ``The Bastard Child Rock''. The ``Preta'' is basically composed by three rocks that were originated along of natural reasons from a single block of arenite in its upper part and of a rough conglomerate in the lower one: between the three rocks, two galleries (thereafter F and G) were thus formed. However, it is easy to see that the ``Preta'' was deeply modified by human intervention: large stones were wedged in exact position between the three original blocks or positioned as a cover. We found that F gallery has an astronomical azimuth of 359 deg and G gallery of 240 deg. Inside the measurement precision (1 deg), the galleries are thus respectively oriented to the meridian and to the sunset of the winter solstice. Furthermore, modern folklore associated to the rock seems to remind very ancient fertility rites. From a statistical analysis of the alignments and an archaeological study of the complex, we conclude that ``Preta 'ru Mulacchio'' is most probably a monument, dated to an epoch presently unknown but possibly preceding the Greek colonization of Cilento, built in order to determine with a high precision the winter solstice because of cerimonial reasons, probably connected with fertility rites.

  11. Geochemical and mineralogical fingerprints to distinguish the exploited ferruginous mineralisations of Grotta della Monaca (Calabria, Italy).

    PubMed

    Dimuccio, Luca Antonio; Rodrigues, Nelson; Larocca, Felice; Pratas, João; Amado, Ana Margarida; de Carvalho, Luís A E Batista

    2017-02-15

    This study examines the geochemical and mineralogical variations in the ferruginous mineralisations that crop out within Grotta della Monaca, which is considered to be the most striking and best known example of a prehistoric iron mine-cave from the southern Apennines (Calabria, Italy). Previous archaeological research identified three local and distinct ancient exploitation phases of these ferruginous mineralisations: (1) an Upper Palaeolithic phase; (2) a Late Neolithic phase; and (3) a post-Medieval phase. These materials, which have various forms of complex mineralogical admixtures and range in colour from yellow-orange to red and darker brown shades, mainly consist of iron oxides/hydroxides (essentially goethite and lepidocrocite), which are often mixed with subordinate and variable amounts of other matrix components (carbonates, sulphates, arsenates, silicates and organic matter). Such ferruginous mineralisations generally correspond to geochemically heterogeneous massive dyke/vein/mammillary/stratiform facies that are exposed within the local caves along open fractures and inclined bedding planes and that partially cover cave wall niches/notches/pockets and ceiling cupolas/holes. Selected samples/sub-samples are analysed through a multi-technique approach with a handheld portable X-ray Fluorescence, X-ray Diffraction, micro-Raman and Fourier Transform Infrared spectroscope (both conventional and attenuated total reflection), which is combined with subsequent multivariate statistical analysis of the elemental concentration data. The geochemical and mineralogical results are used to individualise similar compositional clusters. As expected, the identified groups, each of which has very specific geochemical-mineralogical "fingerprints" and spatial distributions, enable us to identify the sampled ferruginous mineralisations. These specific mineral resources can be compared to similar raw materials that are found in other neighbouring archaeological sites, with

  12. A cucumber DELLA homolog CsGAIP may inhibit staminate development through transcriptional repression of B class floral homeotic genes.

    PubMed

    Zhang, Yan; Liu, Bin; Yang, Sen; An, Jingbo; Chen, Chunhua; Zhang, Xiaolan; Ren, Huazhong

    2014-01-01

    In hermaphroditic Arabidopsis, the phytohormone gibberellin (GA) stimulates stamen development by opposing the DELLA repression of B and C classes of floral homeotic genes. GA can promote male flower formation in cucumber (Cucumis sativus L.), a typical monoecious vegetable with unisexual flowers, and the molecular mechanism remains unknown. Here we characterized a DELLA homolog CsGAIP in cucumber, and we found that CsGAIP is highly expressed in stem and male flower buds. In situ hybridization showed that CsGAIP is greatly enriched in the stamen primordia, especially during the hermaphrodite stage of flower development. Further, CsGAIP protein is located in nucleus. CsGAIP can partially rescue the plant height, stamen development and fertility phenotypes of Arabidopsis rga-24/gai-t6 mutant, and ectopic expression of CsGAIP in wide-type Arabidopsis results in reduced number of stamens and decreased transcription of B class floral homeotic genes APETALA3 (AP3) and PISTILLATA (PI). Our data suggest that monoecious CsGAIP may inhibit staminate development through transcriptional repression of B class floral homeotic genes in Arabidopsis.

  13. Yeast and mould dynamics in Caciofiore della Sibilla cheese coagulated with an aqueous extract of Carlina acanthifolia All.

    PubMed

    Cardinali, Federica; Taccari, Manuela; Milanović, Vesna; Osimani, Andrea; Polverigiani, Serena; Garofalo, Cristiana; Foligni, Roberta; Mozzon, Massimo; Zitti, Silvia; Raffaelli, Nadia; Clementi, Francesca; Aquilanti, Lucia

    2016-08-01

    Caciofiore della Sibilla is a speciality ewes' milk cheese traditionally manufactured in a foothill area of the Marche region (Central Italy) with a crude extract of fresh young leaves of Carlina acanthifolia All. subsp. acanthifolia as a coagulating agent. The fungal dynamics and diversity of this speciality cheese were investigated throughout the manufacturing and 20-day ripening process, using a combined PCR-DGGE approach. The fungal biota of a control ewes' milk cheese, manufactured with the same batch of milk coagulated with a commercial animal rennet, was also monitored by PCR-DGGE, in order to investigate the contribution of the peculiar vegetable coagulant to the fungal diversity and dynamics of the cheese. Based on the overall results collected, the raw milk and the dairy environment represented the main sources of fungal contamination, with a marginal or null contribution of thistle rennet to the fungal diversity and dynamics of Caciofiore della Sibilla cheese. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  14. Sequence variations of the partially dominant DELLA gene Rht-B1c in wheat and their functional impacts.

    PubMed

    Wen, Wen; Deng, Qingyan; Jia, Haiyan; Wei, Lingzhu; Wei, Jingbo; Wan, Hongshen; Yang, Liming; Cao, Wenjin; Ma, Zhengqiang

    2013-08-01

    Rht-B1c, allelic to the DELLA protein-encoding gene Rht-B1a, is a natural mutation documented in common wheat (Triticum aestivum). It confers variation to a number of traits related to cell and plant morphology, seed dormancy, and photosynthesis. The present study was conducted to examine the sequence variations of Rht-B1c and their functional impacts. The results showed that Rht-B1c was partially dominant or co-dominant for plant height, and exhibited an increased dwarfing effect. At the sequence level, Rht-B1c differed from Rht-B1a by one 2kb Veju retrotransposon insertion, three coding region single nucleotide polymorphisms (SNPs), one 197bp insertion, and four SNPs in the 1kb upstream sequence. Haplotype investigations, association analyses, transient expression assays, and expression profiling showed that the Veju insertion was primarily responsible for the extreme dwarfing effect. It was found that the Veju insertion changed processing of the Rht-B1c transcripts and resulted in DELLA motif primary structure disruption. Expression assays showed that Rht-B1c caused reduction of total Rht-1 transcript levels, and up-regulation of GATA-like transcription factors and genes positively regulated by these factors, suggesting that one way in which Rht-1 proteins affect plant growth and development is through GATA-like transcription factor regulation.

  15. A Cucumber DELLA Homolog CsGAIP May Inhibit Staminate Development through Transcriptional Repression of B Class Floral Homeotic Genes

    PubMed Central

    Zhang, Yan; Liu, Bin; Yang, Sen; An, Jingbo; Chen, Chunhua; Zhang, Xiaolan; Ren, Huazhong

    2014-01-01

    In hermaphroditic Arabidopsis, the phytohormone gibberellin (GA) stimulates stamen development by opposing the DELLA repression of B and C classes of floral homeotic genes. GA can promote male flower formation in cucumber (Cucumis sativus L.), a typical monoecious vegetable with unisexual flowers, and the molecular mechanism remains unknown. Here we characterized a DELLA homolog CsGAIP in cucumber, and we found that CsGAIP is highly expressed in stem and male flower buds. In situ hybridization showed that CsGAIP is greatly enriched in the stamen primordia, especially during the hermaphrodite stage of flower development. Further, CsGAIP protein is located in nucleus. CsGAIP can partially rescue the plant height, stamen development and fertility phenotypes of Arabidopsis rga-24/gai-t6 mutant, and ectopic expression of CsGAIP in wide-type Arabidopsis results in reduced number of stamens and decreased transcription of B class floral homeotic genes APETALA3 (AP3) and PISTILLATA (PI). Our data suggest that monoecious CsGAIP may inhibit staminate development through transcriptional repression of B class floral homeotic genes in Arabidopsis. PMID:24632777

  16. The Xanthomonas campestris effector protein XopDXcc8004 triggers plant disease tolerance by targeting DELLA proteins.

    PubMed

    Tan, Leitao; Rong, Wei; Luo, Hongli; Chen, Yinhua; He, Chaozu

    2014-11-01

    Plants protect themselves from the harmful effects of pathogens by resistance and tolerance. Disease resistance, which eliminates pathogens, can be modulated by bacterial type III effectors. Little is known about whether disease tolerance, which sustains host fitness with a given pathogen burden, is regulated by effectors. Here, we examined the effects of the Xanthomonas effector protein XopDXcc8004 on plant disease defenses by constructing knockout and complemented Xanthomonas strains, and performing inoculation studies in radish (Raphanus sativus L. var. radiculus XiaoJinZhong) and Arabidopsis plants. XopDXcc8004 suppresses disease symptoms without changing bacterial titers in infected leaves. In Arabidopsis, XopDXcc8004 delays the hormone gibberellin (GA)-mediated degradation of RGA (repressor of ga1-3), one of five DELLA proteins that repress GA signaling and promote plant tolerance under biotic and abiotic stresses. The ERF-associated amphiphilic repression (EAR) motif-containing region of XopDXcc8004 interacts with the DELLA domain of RGA and might interfere with the GA-induced binding of GID1, a GA receptor, to RGA. The EAR motif was found to be present in a number of plant transcriptional regulators. Thus, our data suggest that bacterial pathogens might have evolved effectors, which probably mimic host components, to initiate disease tolerance and enhance their survival.

  17. Reconstruction of full glacial environments and summer temperatures from Lago della Costa, a refugial site in Northern Italy

    NASA Astrophysics Data System (ADS)

    Samartin, Stéphanie; Heiri, Oliver; Kaltenrieder, Petra; Kühl, Norbert; Tinner, Willy

    2016-07-01

    Vegetation and climate during the last ice age and the Last Glacial Maximum (LGM, ∼23,000-19,000 cal BP) were considerably different than during the current interglacial (Holocene). Cold climatic conditions and growing ice-sheets during the last glaciation radically reduced forest extent in Europe to a restricted number of so-called ;refugia;, mostly located in the southern part of the continent. On the basis of paleobotanical analyses the Euganian Hills (Colli Euganei) in northeastern Italy have previously been proposed as one of the northernmost refugia of temperate trees (e.g. deciduous Quercus, Tilia, Ulmus, Fraxinus excelsior, Acer, Abies alba, Fagus sylvatica, Carpinus and Castanea) in Europe. In this study we provide the first quantitative, vegetation independent summer air temperature reconstruction for Northern Italy spanning the time ∼31,000-17,000 cal yr BP, which covers the coldest periods of the last glacial, including the LGM and Heinrich stadials 1 to 3. Chironomids preserved in a lake sediment core from Lago della Costa (7m a.s.l.), a small lake at the south-eastern edge of the Euganean Hills, allowed quantitative reconstruction of Full and Late Glacial summer air temperatures using a combined Swiss-Norwegian temperature inference model based on chironomid assemblages from 274 lakes. Chironomid and pollen evidence from Lago della Costa derives from finely stratified autochthonous organic gyttja sediments, which excludes major sediment mixing or reworking. After reconstructing paleo-temperatures, we address the question whether climate conditions were warm enough to permit the local survival of temperate tree species during the LGM and whether local expansions and pollen-inferred contractions of temperate tree taxa coincided with chironomid-inferred climatic changes. Our results suggest that chironomids at Lago della Costa have responded to major climatic fluctuations such as temperature decreases during the LGM and Heinrich stadials. The

  18. "I CAMMINI DELLA REGINA" - Open Source based tools for preserving and culturally exploring historical traffic routes.

    NASA Astrophysics Data System (ADS)

    Cannata, Massimiliano; Colombo, Massimo; Antonovic, Milan; Cardoso, Mirko; Delucchi, Andrea; Gianocca, Giancarlo; Brovelli, Maria Antonia

    2015-04-01

    "I CAMMINI DELLA REGINA" (The Via Regina Paths) is an Interreg project funded within the transnational cooperation program between Italy and Switzerland 2007-2013. The aim of this project is the preservation and valorization of the cultural heritage linked to the walking historically paths crossing, connecting and serving the local territories. With the approach of leveraging the already existing tools, which generally consist of technical descriptions of the paths, the project uses the open source geospatial technologies to deploy innovative solutions which can fill some of the gaps in historical-cultural tourism offers. The Swiss part, and particularly the IST-SUPSI team, has been focusing its activities in the realization of two innovative solutions: a mobile application for the survey of historical paths and a storytelling system for immersive cultural exploration of the historical paths. The former, based on Android, allows to apply in a revised manner a consolidated and already successfully used methodology of survey focused on the conservation of the historical paths (Inventory of historical traffic routes in Switzerland). Up to now operators could rely only on hand work based on a combination of notes, pictures and GPS devices synthesized in manually drawn maps; this procedure is error prone and shows many problems both in data updating and extracting for elaborations. Thus it has been created an easy to use interface which allows to map, according to a newly developed spatially enabled data model, paths, morphological elements, and multimedia notes. When connected to the internet the application can send the data to a web service which, after applying linear referencing and further elaborating the data, makes them available using open standards. The storytelling system has been designed to provide users with cultural insights embedded in a multimedial and immersive geospatial portal. Whether the tourist is exploring physically or virtually the desired

  19. The Montessori System of Education: An Examination of Characteristic Features Set Forth in Il Metodo Della Pedagogica Scientifica. Bulletin, 1912, No. 17. Whole Number 489

    ERIC Educational Resources Information Center

    Smith, Anna Tolman

    1912-01-01

    The publication of "Il metodo della pedagogica scientifica," by Dr. Maria Montessori, docent in the University of Rome, giving a full account of the inception and development of the system of education of which she is the author and the simultaneous translation of the work into English and German are events so unusual as to challenge attention.…

  20. DELLA signaling mediates stress-induced cell differentiation in Arabidopsis leaves through modulation of anaphase-promoting complex/cyclosome activity.

    PubMed

    Claeys, Hannes; Skirycz, Aleksandra; Maleux, Katrien; Inzé, Dirk

    2012-06-01

    Drought is responsible for considerable yield losses in agriculture due to its detrimental effects on growth. Drought responses have been extensively studied, but mostly on the level of complete plants or mature tissues. However, stress responses were shown to be highly tissue and developmental stage specific, and dividing tissues have developed unique mechanisms to respond to stress. Previously, we studied the effects of osmotic stress on dividing leaf cells in Arabidopsis (Arabidopsis thaliana) and found that stress causes early mitotic exit, in which cells end their mitotic division and start endoreduplication earlier. In this study, we analyzed this phenomenon in more detail. Osmotic stress induces changes in gibberellin metabolism, resulting in the stabilization of DELLAs, which are responsible for mitotic exit and earlier onset of endoreduplication. Consequently, this response is absent in mutants with altered gibberellin levels or DELLA activity. Mitotic exit and onset of endoreduplication do not correlate with an up-regulation of known cell cycle inhibitors but are the result of reduced levels of DP-E2F-LIKE1/E2Fe and UV-B-INSENSITIVE4, both inhibitors of the developmental transition from mitosis to endoreduplication by modulating anaphase-promoting complex/cyclosome activity, which are down-regulated rapidly after DELLA stabilization. This work fits into an emerging view of DELLAs as regulators of cell division by regulating the transition to endoreduplication and differentiation.

  1. The GATA-type transcription factors GNC and GNL/CGA1 repress gibberellin signaling downstream from DELLA proteins and PHYTOCHROME-INTERACTING FACTORS.

    PubMed

    Richter, René; Behringer, Carina; Müller, Isabel Karin; Schwechheimer, Claus

    2010-09-15

    The phytohormone gibberellin (GA) regulates various developmental processes in plants such as germination, greening, elongation growth, and flowering time. DELLA proteins, which are degraded in response to GA, repress GA signaling by inhibitory interactions with PHYTOCHROME-INTERACTING FACTOR (PIF) family transcription factors. How GA signaling is controlled downstream from the DELLA and PIF regulators is, at present, unclear. Here, we characterize GNC (GATA, NITRATE-INDUCIBLE, CARBON-METABOLISM INVOLVED) and GNL/CGA1 (GNC-LIKE/CYTOKININ-RESPONSIVE GATA FACTOR1), two homologous GATA-type transcription factors from Arabidopsis thaliana that we initially identified as GA-regulated genes. Our genetic analyses of loss-of-function mutants and overexpression lines establish that GNC and GNL are functionally redundant regulators of germination, greening, elongation growth and flowering time. We further show by chromatin immunoprecipitation that both genes are potentially direct transcription targets of PIF transcription factors, and that their expression is up-regulated in pif mutant backgrounds. In line with a key role of GNC or GNL downstream from DELLA and PIF signaling, we find that their overexpression leads to gene expression changes that largely resemble those observed in a ga1 biosynthesis mutant or a pif quadruple mutant. These findings, together with the fact that gnc and gnl loss-of-function mutations suppress ga1 phenotypes, support the hypothesis that GNC and GNL are important repressors of GA signaling downstream from the DELLA and PIF regulators.

  2. DELLA Signaling Mediates Stress-Induced Cell Differentiation in Arabidopsis Leaves through Modulation of Anaphase-Promoting Complex/Cyclosome Activity1[W][OA

    PubMed Central

    Claeys, Hannes; Skirycz, Aleksandra; Maleux, Katrien; Inzé, Dirk

    2012-01-01

    Drought is responsible for considerable yield losses in agriculture due to its detrimental effects on growth. Drought responses have been extensively studied, but mostly on the level of complete plants or mature tissues. However, stress responses were shown to be highly tissue and developmental stage specific, and dividing tissues have developed unique mechanisms to respond to stress. Previously, we studied the effects of osmotic stress on dividing leaf cells in Arabidopsis (Arabidopsis thaliana) and found that stress causes early mitotic exit, in which cells end their mitotic division and start endoreduplication earlier. In this study, we analyzed this phenomenon in more detail. Osmotic stress induces changes in gibberellin metabolism, resulting in the stabilization of DELLAs, which are responsible for mitotic exit and earlier onset of endoreduplication. Consequently, this response is absent in mutants with altered gibberellin levels or DELLA activity. Mitotic exit and onset of endoreduplication do not correlate with an up-regulation of known cell cycle inhibitors but are the result of reduced levels of DP-E2F-LIKE1/E2Fe and UV-B-INSENSITIVE4, both inhibitors of the developmental transition from mitosis to endoreduplication by modulating anaphase-promoting complex/cyclosome activity, which are down-regulated rapidly after DELLA stabilization. This work fits into an emerging view of DELLAs as regulators of cell division by regulating the transition to endoreduplication and differentiation. PMID:22535421

  3. Human impact and Holocene climatic change in the archaeological site 'Piani della Corona

    NASA Astrophysics Data System (ADS)

    Pelle, Teresa; Scarciglia, Fabio; La Russa, Mauro F.; Natali, Elena; Tinè, Vincenzo

    2010-05-01

    A pedoarchaeological study was carried out in the archaeological site "Piani della Corona", located on a wide terrace at 500 m a.s.l. along the southwestern coast of Calabria, in southern Italy. The archaeological excavations exhumed an extensive settlement related to old to medium Bronze Age phases and traces of late Neolithic human colonization. On the basis of archaeological finds the pedostratigraphic succession can be partly dated. It consists of soils with variable features and andic properties, which include yellowish-brown (in places more reddish), deep argillic (Bt) horizons with variable amounts of clay coatings in pores and dark brown infillings of soil material rich in organic matter, in places overlaid by thin, severely truncated, brown to dark brown, organic-mineral (A) horizons. These layers include late Neolithic ceramic artefacts (Diana style facies) and typical incineration burials found in biconical vases, that can be referred to 6500-5000 years BP. The prehistoric layers are widely overlaid and strongly superimposed by a paleosurface of the early to medium Bronze age. This surface is affected by many pole holes left by large rectangular, apsidal wooden huts (not preserved), ploughed furrows, excavated cisterns, ditches and trenches, often filled by organic-rich dark brown material. Also hearths with charcoal remains, burials, vases and other diagnostic ceramic fragments occur. The upper portion of the pedostratigraphic succession consists of thicker brown A horizons, that appear cyclically ploughed during historical times (archaeologically not well dated as a consequence of their reworking for agricultural practices), with abrupt irregular boundaries often entering the underlying horizons. Micromorphological observations confirmed the presence of clay coatings within pores of Bt horizons, showing that they represent relict features (i.e. related to inactive illuvial processes, at present), as often fragmented and with smooth-banded to grainy

  4. Geophysic data interperetation of Passo della Morte landslide: Eastern Italian Alps

    NASA Astrophysics Data System (ADS)

    Zoppe', G.; Costa, G.; Marcato, G.; Forte, E.

    2012-04-01

    The Passo della Morte block-slide covers a relative large area in the Carnic Alps, along the left side of the Tagliamento River, between Forni di Sotto and Ampezzo (N-E of Italy). The high seismicity and the presence of the landslide increase the risk associated to the interest area. Moreover the large volume of material involved in the landslide (a few million of cubic meters), the presence of important infrastructure such as the road and two tunnels which cross the landslide, as well as the presence of the Tagliamento River that flow at the foot of the landslide, make the area very vulnerable. This study concerns with the western part of the Deep Seated Gravitational Slope Deformation (DSGSD). It focuses on the potential instability of a rock slope (crossed by road tunnels) and its connection with the DSGSD activity. The main objectives of this study are: monitoring the rock mass movement, studying the seismic site effect and defining the stratigraphic and geological characteristics of involved materials. Two vibration sensors have been installed inside the potential landslide: a short-period seismometer and a piezoelectric transducer. The microseismic activity recorded by the sensors has been analyzed, with particular regard to periods characterized by rapid changes in recorded seismic signals, and then correlated with the precipitation trend to evaluate the existence of a possible correlation between these phenomena. The microseismic activity study has highlighted the existence of a close link between microseisms and acoustic emissions recorded respectively by the seismometer and by the piezoelectric transducer. In addition, the comparison with the rainfall pattern has shown a direct relationship between different rainfall events and the sharp increase of microseismic activity detected by the two instruments. The correlation is good, even if acoustic emissions appear to be more sensitive than microseisms to short duration and low intensity rainfall events. The

  5. Zoobotryon verticillatum Della Chiaje, 1822 (Bryozoa), a new occurrence in the archipelago of the Azores (North-Eastern Atlantic).

    PubMed

    Amat, Jaen Nieto; Tempera, Fernando

    2009-05-01

    The new occurrence of the bryozoan Zoobotryon verticillatum Della Chiaje, 1822 is herein recorded in multiple places throughout Azores archipelago. Where introduced, this species has caused important ecological and economical damage and therefore is regarded as invasive. In the Azores, no detrimental effects have yet been noted. The species is so far restricted to marinas (Horta, Faial Island; Vila Franca do Campo, São Miguel Island) and a natural coastal pool located near a secondary harbour (Lajes do Pico, Pico Island). A total of 29 colonies were counted during a specific survey conducted in August 2008 in the marina of Horta. The distribution of the species throughout the eastern and central island groups denotes a wide dispersion area and offers control or eradication measures a low probability of success together with the lack of harbour management practices that could effectively prevent the arrival, settlement and dispersal of non-native species transported by human-assisted means.

  6. The Palazzo della Ragione in Padua: Representation and Communication of Art, Architecture, and Astrology of a Civic Monument

    NASA Astrophysics Data System (ADS)

    Borgherini, M.; Garbin, E.

    2011-06-01

    Eight centuries of the history of art and of Padua's scientific and technological culture deposited on the stones and frescoes of its Palace of Law ("Palazzo della Ragione") make this great work of urban architecture a part of the city's collective identity. This "palimpsest", legible only to a restricted circle of specialists, should be accessible to a vaster public interested in understanding this object symbol of local culture. The project planned for interactive exploration on the web is a series of digital models, employing tomographic-endoscopic visualizations and, in future, multi-resolution images. The various models devised allow the visitor to superimpose the Palace's current conditions on the various transformations undergone over the centuries. Similarly, comparisons can be made between the astrological fresco cycle with maps of the heavens, cosmological hypotheses, ancient and contemporary astrological treatises, and the related exchange of knowledge between the Orient and the Occident.

  7. PubMed

    Jefferson, Tom

    2017-09-01

    Riassunto La pubblicazione di Unanticipated outcomes, la storia personale di Jerome P. Kassirer, ex direttore del New England Journal of Medicine, offre l'opportunità di considerare i principi etici dell'editoria biomedica e scientifica. Il conflitto di interessi, le dichiarazioni e la frode influenzano la credibilità della comunicazione medica, che poggia sulla robustezza e sulla trasparenza dei suoi processi. Non tutto è ancora perduto, ma dobbiamo essere guidati da forti principi morali e da un quadro coerente di valori.

  8. Comparative Transcriptome Analysis of Genes Involved in GA-GID1-DELLA Regulatory Module in Symbiotic and Asymbiotic Seed Germination of Anoectochilus roxburghii (Wall.) Lindl. (Orchidaceae).

    PubMed

    Liu, Si-Si; Chen, Juan; Li, Shu-Chao; Zeng, Xu; Meng, Zhi-Xia; Guo, Shun-Xing

    2015-12-18

    Anoectochilus roxburghii (Wall.) Lindl. (Orchidaceae) is an endangered medicinal plant in China, also called "King Medicine". Due to lacking of sufficient nutrients in dust-like seeds, orchid species depend on mycorrhizal fungi for seed germination in the wild. As part of a conservation plan for the species, research on seed germination is necessary. However, the molecular mechanism of seed germination and underlying orchid-fungus interactions during symbiotic germination are poorly understood. In this study, Illumina HiSeq 4000 transcriptome sequencing was performed to generate a substantial sequence dataset of germinating A. roxburghii seed. A mean of 44,214,845 clean reads were obtained from each sample. 173,781 unigenes with a mean length of 653 nt were obtained. A total of 51,514 (29.64%) sequences were annotated, among these, 49 unigenes encoding proteins involved in GA-GID1-DELLA regulatory module, including 31 unigenes involved in GA metabolism pathway, 5 unigenes encoding GID1, 11 unigenes for DELLA and 2 unigenes for GID2. A total of 11,881 genes showed significant differential expression in the symbiotic germinating seed sample compared with the asymbiotic germinating seed sample, of which six were involved in the GA-GID1-DELLA regulatory module, and suggested that they might be induced or suppressed by fungi. These results will help us understand better the molecular mechanism of orchid seed germination and orchid-fungus symbiosis.

  9. Comparative Transcriptome Analysis of Genes Involved in GA-GID1-DELLA Regulatory Module in Symbiotic and Asymbiotic Seed Germination of Anoectochilus roxburghii (Wall.) Lindl. (Orchidaceae)

    PubMed Central

    Liu, Si-Si; Chen, Juan; Li, Shu-Chao; Zeng, Xu; Meng, Zhi-Xia; Guo, Shun-Xing

    2015-01-01

    Anoectochilus roxburghii (Wall.) Lindl. (Orchidaceae) is an endangered medicinal plant in China, also called “King Medicine”. Due to lacking of sufficient nutrients in dust-like seeds, orchid species depend on mycorrhizal fungi for seed germination in the wild. As part of a conservation plan for the species, research on seed germination is necessary. However, the molecular mechanism of seed germination and underlying orchid-fungus interactions during symbiotic germination are poorly understood. In this study, Illumina HiSeq 4000 transcriptome sequencing was performed to generate a substantial sequence dataset of germinating A. roxburghii seed. A mean of 44,214,845 clean reads were obtained from each sample. 173,781 unigenes with a mean length of 653 nt were obtained. A total of 51,514 (29.64%) sequences were annotated, among these, 49 unigenes encoding proteins involved in GA-GID1-DELLA regulatory module, including 31 unigenes involved in GA metabolism pathway, 5 unigenes encoding GID1, 11 unigenes for DELLA and 2 unigenes for GID2. A total of 11,881 genes showed significant differential expression in the symbiotic germinating seed sample compared with the asymbiotic germinating seed sample, of which six were involved in the GA-GID1-DELLA regulatory module, and suggested that they might be induced or suppressed by fungi. These results will help us understand better the molecular mechanism of orchid seed germination and orchid-fungus symbiosis. PMID:26694378

  10. GsGASA1 mediated root growth inhibition in response to chronic cold stress is marked by the accumulation of DELLAs.

    PubMed

    Li, Kun-Lun; Bai, Xi; Li, Yong; Cai, Hua; Ji, Wei; Tang, Li-Li; Wen, Yi-Dong; Zhu, Yan-Ming

    2011-12-15

    Low, but not freezing temperatures are a major factor limiting plant vegetative growth and development. It is not clear what signaling mechanism is used to limit plant growth in response to chronic low temperatures, thus it is important to continue to isolate and characterize genes whose activity/expression correlate well with cold responses. In this study, a novel GASA gene was isolated from Glycine soja and named GsGASA1. Quantitative real-time PCR analysis indicated that GsGASA1 expression responded to exogenous gibberellic acid (GA) and abscisic acid (ABA) treatments. Compared with wild-type plants under long-term cold treatment, the constitutive expression of GsGASA1 in transgenic Arabidopsis plants enhanced the inhibition of root elongation, while also increasing the transcript levels of RGL2 and RGL3, two of five DELLA genes in Arabidopsis. DELLA is a class of transcriptional regulators in GA signaling pathway restraining plant growth. Our results imply that GsGASA1 participates in chronic cold-induced root growth inhibition with the accumulation of DELLA genes. Lastly, a subcellular localization study using a yellow fluorescent protein (YFP) fusion protein indicated that GsGASA1 was localized to the plasma membrane, cytoplasm and nucleus. Copyright © 2011 Elsevier GmbH. All rights reserved.

  11. A scientific approach to the characterization of the painting materials of Fra Mattia della Robbia polychrome terracotta altarpiece

    NASA Astrophysics Data System (ADS)

    Amadori, M. L.; Barcelli, S.; Casoli, A.; Mazzeo, R.; Prati, S.

    2013-12-01

    During the last restoration (2008-2011) of the polychrome terracotta altarpiece called Coronation of Virgin between Saints Rocco, Sebastian, Peter martyr and Antonio abbot, located in the collegiate church of S. Maria Assunta in Montecassiano (Macerata, Italy), scientific investigations were carried out to acquire detailed information about the painting technique. The identification of materials allowed a correct restoration. The altarpiece is almost entirely realized by Marco della Robbia (Fra Mattia), dates back to the first half of the XVI century and represents an interesting example of painted terracotta produced by using two different techniques: glazed polychrome terracotta and the "cold painting" technique. The characterization of the samples' material constituents was obtained by analysing the cross-sections and the fragments by different techniques (optical, SEM-EDS and ATR-FTIR microscopy as well as GC-MS), as the real nature of a component is often difficult to assess with one single technique. The optical microscope examination of paint cross-sections shows the presence of many layers, indicating the complexity of the paint stratigraphic morphologies. The original polychromy of della Robbia's masterpiece is constituted of cinnabar, red lake, red lead, orpiment, red ochre, lead white, lead tin yellow, green earth and raw umber. Two different types of gilding technique have been distinguished. The first one presents a glue mordant, and the second one shows an oil mordant composed by a mixture of red lead, red ochre, cinnabar and orpiment. The GC-MS analysis allowed the characterisation of linseed oil and a mixture of animal glue and egg as binding media stratigraphically located by the use of ATR-FTIR mapping microscopy. The analytical results of the painted terracotta integrated investigations show that original technique adopted is characterised by the application of pigments in an oil-binding medium directly applied on the substrates, probably treated

  12. DELLA Proteins and Their Interacting RING Finger Proteins Repress Gibberellin Responses by Binding to the Promoters of a Subset of Gibberellin-Responsive Genes in Arabidopsis[C][W

    PubMed Central

    Park, Jeongmoo; Nguyen, Khoa Thi; Park, Eunae; Jeon, Jong-Seong; Choi, Giltsu

    2013-01-01

    DELLA proteins, consisting of GA INSENSITIVE, REPRESSOR OF GA1-3, RGA-LIKE1 (RGL1), RGL2, and RGL3, are central repressors of gibberellin (GA) responses, but their molecular functions are not fully understood. We isolated four DELLA-interacting RING domain proteins, previously designated as BOTRYTIS SUSCEPTIBLE1 INTERACTOR (BOI), BOI-RELATED GENE1 (BRG1), BRG2, and BRG3 (collectively referred to as BOIs). Single mutants of each BOI gene failed to significantly alter GA responses, but the boi quadruple mutant (boiQ) showed a higher seed germination frequency in the presence of paclobutrazol, precocious juvenile-to-adult phase transition, and early flowering, all of which are consistent with enhanced GA signaling. By contrast, BOI overexpression lines displayed phenotypes consistent with reduced GA signaling. Analysis of a gai-1 boiQ pentuple mutant further indicated that the GAI protein requires BOIs to inhibit a subset of GA responses. At the molecular level, BOIs did not significantly alter the stability of a DELLA protein. Instead, BOI and DELLA proteins are targeted to the promoters of a subset of GA-responsive genes and repress their expression. Taken together, our results indicate that the DELLA and BOI proteins inhibit GA responses by interacting with each other, binding to the same promoters of GA-responsive genes, and repressing these genes. PMID:23482857

  13. The Tempio della Consolazione in Todi: Integrated Geomatic Techniques for a Monument Description Including Structural Damage Evolution in Time

    NASA Astrophysics Data System (ADS)

    Radicioni, F.; Matracchi, P.; Brigante, R.; Brozzi, A.; Cecconi, M.; Stoppini, A.; Tosi, G.

    2017-05-01

    The Tempio della Consolazione in Todi (16th cent.) has always been one of the most significant symbols of the Umbrian landscape. Since the first times after its completion (1606) the structure has exhibited evidences of instability, due to foundation subsiding and/or seismic activity. Structural and geotechnical countermeasures have been undertaken on the Tempio and its surroundings from the 17th century until recent times. Until now a truly satisfactory analysis of the overall deformation and attitude of the building has not been performed, since the existing surveys record the overhangs of the pillars, the crack pattern or the subsidence over limited time spans. Describing the attitude of the whole church is in fact a complex operation due to the architectural character of the building, consisting of four apses (three polygonal and one semicircular) covered with half domes, which surround the central area with the large dome. The present research aims to fill the gap of knowledge with a global study based on geomatic techniques for an accurate 3D reconstruction of geometry and attitude, integrated with a historical research on damage and interventions and a geotechnical analysis. The geomatic survey results from the integration of different techniques: GPS-GNSS for global georeferencing, laser scanning and digital photogrammetry for an accurate 3D reconstruction, high precision total station and geometric leveling for a direct survey of deformations and cracks, and for the alignment of the laser scans. The above analysis allowed to assess the dynamics of the cracks occurred in the last 25 years by a comparison with a previous survey. From the photographic colour associated to the point cloud was also possible to map the damp patches showing on the domes intrados, mapping their evolution over the last years.

  14. Release of the repressive activity of rice DELLA protein SLR1 by gibberellin does not require SLR1 degradation in the gid2 mutant.

    PubMed

    Ueguchi-Tanaka, Miyako; Hirano, Ko; Hasegawa, Yasuko; Kitano, Hidemi; Matsuoka, Makoto

    2008-09-01

    The rice (Oryza sativa) DELLA protein SLR1 acts as a repressor of gibberellin (GA) signaling. GA perception by GID1 causes SLR1 protein degradation involving the F-box protein GID2; this triggers GA-associated responses such as shoot elongation and seed germination. In GA-insensitive and GA biosynthesis mutants, SLENDER RICE1 (SLR1) accumulates to high levels, and the severity of dwarfism is usually correlated with the level of SLR1 accumulation. An exception is the GA-insensitive F-box mutant gid2, which shows milder dwarfism than mutants such as gid1 and cps even though it accumulates higher levels of SLR1. The level of SLR1 protein in gid2 was decreased by loss of GID1 function or treatment with a GA biosynthesis inhibitor, and dwarfism was enhanced. Conversely, overproduction of GID1 or treatment with GA(3) increased the SLR1 level in gid2 and reduced dwarfism. These results indicate that derepression of SLR1 repressive activity can be accomplished by GA and GID1 alone and does not require F-box (GID2) function. Evidence for GA signaling without GID2 was also provided by the expression behavior of GA-regulated genes such as GA-20oxidase1, GID1, and SLR1 in the gid2 mutant. Based on these observations, we propose a model for the release of GA suppression that does not require DELLA protein degradation.

  15. The implementation of a Community Health Centre-based primary care model in Italy. The experience of the Case della Salute in the Emilia-Romagna Region.

    PubMed

    Odone, Anna; Saccani, Elisa; Chiesa, Valentina; Brambilla, Antonio; Brianti, Ettore; Fabi, Massimo; Curcetti, Clara; Donatini, Andrea; Balestrino, Antonio; Lombardi, Marco; Rossi, Giuseppina; Saccenti, Elena; Signorelli, Carlo

    2016-01-01

    The Comunity Health Centre (CHC) primary care model is a team-based health care delivery model intended to provide comprehensive and continuous medical care to patients within a defined community. The CHC, Case della Salute in Italian, model was introduced in the Emilia-Romagna Region in 2010. We present updated data on the implementation on the CHC Case della Salute primary care model in the Emilia-Romagna Region. There are 67 operating CHCs in Emilia-Romagna (update March 2015); 26 small (39%), 24 medium (36%) and 17 large (25%). Since 2011 the number of operating CHCs has increased by 60%, reaching 55% of the target planned CHCs (n. = 122). There is, on average, one running CHC per 66.524 inhabitants. 16% of total general practitioners (GPs) and 8.4% of total family paediatricians working in Emilia-Romagna have their practice in CHCs. CHCs offer primary and specialist integrated care, prevention services, health education and social care. Although preliminary results suggest CHCs have fostered primary care's quality and efficiency, more research is needed to assess their impact on improving clinical, social and economic outcomes.

  16. Reconstruction of full glacial environments and summer air temperatures from Lago della Costa, a refugial site in northeastern Italy.

    NASA Astrophysics Data System (ADS)

    Samartin, S. V.; Heiri, O.; Boltshauser-Kaltenrieder, P.; Tinner, W.

    2014-12-01

    Vegetation and climate during the Last Glacial Maximum (LGM) were considerably different than during the current interglacial (Holocene). In Europe large areas north of 40°N were entirely covered by continental ice-sheets and widespread permafrost, with temperatures around 10-20°C lower than at present, whereas further south aridity and temperatures 7-10°C cooler than today occurred. Cool climatic conditions and growing ice-sheets during the LGM radically reduced forest extent and diversity in Europe to a restricted number of so-called "refugia", mostly located in the southern part of the continent. The Euganian Hills in northeastern Italy are supposed to be one of the northernmost refugia of thermophilous mixed oak forest species (e.g. deciduous Quercus, Tilia, Ulmus, Fraxinus excelsior, Acer, Carpinus, Castanea) as well of some temperate mesophilous species (e.g. Fagus sylvatica, Abies alba) in Europe. In this study we present the first European chironomid-based quantitative temperature reconstruction for the LGM and address the question whether climate conditions were warm enough to permit the local survival of Quercetum mixtum species between ca. 31'000-17'000 cal yr BP. Chironomids preserved in a lake sediment core from Lago della Costa (7m a.s.l.), a lake on the border of the Euganean Hills in northeastern Italy, allowed quantitative reconstruction of Full and Late Glacial July air temperatures using a combined Swiss-Norwegian temperature inference model based on chironomid assemblages from 274 lakes. Our results suggest that July air temperatures never fell below 10°C which are considered necessary for forest growth. In general, mild climatic conditions prevailed between ca. 31'000-17'000 cal yr BP with temperatures ranging from ca. 11°C to 15.7°C. The expansion of thermophilous trees such as Quercus, Tilia, Ulmus, Fraxinus excelsior, Acer, Carpinus, Castanea (Quercetum mixtum) between ca. 30'000-23'000 cal yr BP can most likely be explained by climate

  17. Comparative reproductive biology of the social parasite Acromyrmex ameliae de Souza, Soares & Della Lucia and of its host Acromyrmex subterraneus subterraneus Forel (Hymenoptera: Formicidae).

    PubMed

    Soares, Ilka M F; Della Lucia, Terezinha M C; Pereira, Alice S; Serrão, José E; Ribeiro, Myriam M R; De Souza, Danival J

    2010-01-01

    Social parasites exhibit several characteristics that allow them to exploit their host species efficiently. The smaller size of parasite species is a trait commonly found in ants. In this work, we investigated several aspects of the reproductive biology of Acromyrmex ameliae De Souza, Soares & Della Lucia, a recently discovered parasite of Acromyrmex subterraneus subterraneus Forel. Sexuals of A. ameliae are substantially smaller than those from host species. Parasite queens laid significantly less worker eggs than host queens and inhibit sexual production of the host. The sex ratio of parasite species is highly female biased. Interestingly, we have observed parasite coupling on the laboratory, inside the nests and in the ground, opening the possibility to use controlled mating to study genetic approaches of parasitism in the ants.

  18. Challenges and Opportunities for the Implementation of H-Bim with Regards to Historical Infrastructures: a Case Study of the Ponte Giorgini in Castiglione della Pescaia (grosseto - Italy)

    NASA Astrophysics Data System (ADS)

    Donato, V.; Biagini, C.; Bertini, G.; Marsugli, F.

    2017-05-01

    Historical Building Information Modeling (H-BIM) has been widely documented in literature and is becoming more popular with government bodies, who are increasingly choosing to make its use mandatory in public procurements and contracts. Although the system seems to be one of the best approaches for managing data and driving the decision-making process, several difficulties arise due to the amount of effort required in the initial phases, when the data derived from a geometrical survey must be converted into parametric elements. Moreover, users must decide on a "level of geometrical simplification" a long time in advance, and this inevitably leads to a loss of geometrical data. From this perspective, our research describes a procedure to optimize the workflow of information for existing artefacts, in order to achieve a "lean" H-BIM. In this article, we will analyse two aspects: the first relates to the level of accuracy in a digital model created from the two different point clouds achieved from laser scanner and form images, while the second concerns the conversion of this information into parametric elements (Building Object Models- BOMs) that need to have specific characteristics. The case study we are presenting is the "Ponte Giorgini" ("Giorgini Bridge") in Castiglione della Pescaia (Grosseto - Italy).

  19. Laser doppler and radar interferometer for contactless measurements on unaccessible tie-rods on monumental buildings: Santa Maria della Consolazione Temple in Todi

    NASA Astrophysics Data System (ADS)

    Gioffré, M.; Cavalagli, N.; Pepi, C.; Trequattrini, M.

    2017-01-01

    Non-contact measurements can be effectively used in civil engineering to assess the variation of structural performance with time. In the last decades this approach has received considerable interests from researchers working in the field of structural health monitoring (SHM). Indeed, non-contact measurements are very attractive because it is possible to perform non intrusive and non destructive investigations even being at a significant distance from the targets. Within this context, contactless measurements of the tie-rod vibrations in the Santa Maria della Consolazione Temple in Todi (Italy) are presented in this paper. In particular, laser vibrometer and radar interferometer measurements are used to estimate natural frequencies and mode shapes. This information is crucial to obtain the tensile axial force in the tie-rods, which can be used as an indicator of structural integrity or possible failure. Furthermore, a novel approach is proposed where drones (Unmanned Aerial Vehicles) can be successfully used to improve the effectiveness and the accuracy of the experimental activities.

  20. Meiobenthic Communities Associated with the Seasonal Cycle of Growth and Decay of Ulva rigidaAgardh in the Palude Della Rosa, Lagoon of Venice

    NASA Astrophysics Data System (ADS)

    Villano, N.; Warwick, R. M.

    1995-08-01

    Eutrophication in the Palude della Rosa, in the Lagoon of Venice, results from agricultural runoff giving rise to a seasonal cycle of proliferation and subsequent decomposition of the green alga Ulva rigidaduring the summer months, with a dramatic fall in oxygen levels. A survey of the meiofauna at 42 stations in the Palude in December 1991 showed that there were two distinct associations of nematodes and total meiofauna (nematodes plus copepods), one associated with that part of the Palude where Ulvaattains a high biomass, and another where Ulvabiomass is low or absent. Species characteristic of the Ulvaregion include nematodes of the genus Diplolaimellaand copepods of the genus Tisbe, both of which are known from elsewhere to be associated with decaying plant material and implicated in the decomposition process. In the Ulvaregion both diversity (as evidenced from k-dominance curves) and species composition (using non-metric MDS) varied considerably from season to season, associated with the seasonal cycle of growth and decay of Ulva, but diversity and species composition were more stable seasonally in the non- Ulvaregion. For the copepods alone, differences between the Ulvaand non- Ulvaregions were not as evident and species composition in both regions changes seasonally in the same way, although diversity was only reduced markedly in the summer at the Ulvastations. We conclude that it is not only likely that the Ulvacycle controls seasonal changes in meiobenthic community composition, but in turn the meiobenthic community has some control over the Ulvacycle.

  1. Characterization of the procera tomato mutant shows novel functions of the SlDELLA protein in the control of flower morphology, cell division and expansion, and the auxin-signaling pathway during fruit-set and development.

    PubMed

    Carrera, Esther; Ruiz-Rivero, Omar; Peres, Lazaro Eustaquio Pereira; Atares, Alejandro; Garcia-Martinez, Jose Luis

    2012-11-01

    procera (pro) is a tall tomato (Solanum lycopersicum) mutant carrying a point mutation in the GRAS region of the gene encoding SlDELLA, a repressor in the gibberellin (GA) signaling pathway. Consistent with the SlDELLA loss of function, pro plants display a GA-constitutive response phenotype, mimicking wild-type plants treated with GA₃. The ovaries from both nonemasculated and emasculated pro flowers had very strong parthenocarpic capacity, associated with enhanced growth of preanthesis ovaries due to more and larger cells. pro parthenocarpy is facultative because seeded fruits were obtained by manual pollination. Most pro pistils had exserted stigmas, thus preventing self-pollination, similar to wild-type pistils treated with GA₃ or auxins. However, Style2.1, a gene responsible for long styles in noncultivated tomato, may not control the enhanced style elongation of pro pistils, because its expression was not higher in pro styles and did not increase upon GA₃ application. Interestingly, a high percentage of pro flowers had meristic alterations, with one additional petal, sepal, stamen, and carpel at each of the four whorls, respectively, thus unveiling a role of SlDELLA in flower organ development. Microarray analysis showed significant changes in the transcriptome of preanthesis pro ovaries compared with the wild type, indicating that the molecular mechanism underlying the parthenocarpic capacity of pro is complex and that it is mainly associated with changes in the expression of genes involved in GA and auxin pathways. Interestingly, it was found that GA activity modulates the expression of cell division and expansion genes and an auxin signaling gene (tomato AUXIN RESPONSE FACTOR7) during fruit-set.

  2. A DELLA gene, RhGAI1, is a direct target of EIN3 and mediates ethylene-regulated rose petal cell expansion via repressing the expression of RhCesA2.

    PubMed

    Luo, Jing; Ma, Nan; Pei, Haixia; Chen, Jiwei; Li, Jing; Gao, Junping

    2013-11-01

    Ethylene plays an important role in organ growth. In Arabidopsis, ethylene can inhibit root elongation by stabilizing DELLA proteins. In previous work, it was found that ethylene suppressed cell expansion in rose petals, and five unisequences of DELLA genes are induced by ethylene. However, the mechanism of transcriptional regulation of DELLA genes by ethylene is still not clear. The results showed that the expression of RhGAI1 was induced in both ethylene-treated and ETR gene-silenced rose petals, and the promoter activity of RhGAI1 was strongly induced by RhEIN3-3 in Arabidopsis protoplasts. What is more, RhEIN3-3 could bind to the promoter of RhGAI1 directly in an electrophoretic mobility shift assay (EMSA). Cell expansion was suppressed in RhGAI1-Δ17-overexpressed Arabidopsis petals and promoted in RhGAI1-silenced rose petals. Moreover, in RhGAI1-silenced petals, the expression of nine cell expansion-related genes was clearly changed, and RhGAI1 can bind to the promoter of RhCesA2 in an EMSA. These results suggested that RhGAI1 was regulated by ethylene at the transcriptional level, and RhGAI1 was a direct target of RhEIN3-3. Also, RhGAI1 was shown to be involved in cell expansion partially through regulating the expression of cell expansion-related genes. Furthermore, RhCesA2 was a direct target of RhGAI1. This work uncovers the transcriptional regulation of RhGAI1 by ethylene and provides a better understanding of how ethylene regulates petal expansion in roses.

  3. A DELLA gene, RhGAI1, is a direct target of EIN3 and mediates ethylene-regulated rose petal cell expansion via repressing the expression of RhCesA2

    PubMed Central

    Gao, Junping

    2013-01-01

    Ethylene plays an important role in organ growth. In Arabidopsis, ethylene can inhibit root elongation by stabilizing DELLA proteins. In previous work, it was found that ethylene suppressed cell expansion in rose petals, and five unisequences of DELLA genes are induced by ethylene. However, the mechanism of transcriptional regulation of DELLA genes by ethylene is still not clear. The results showed that the expression of RhGAI1 was induced in both ethylene-treated and ETR gene-silenced rose petals, and the promoter activity of RhGAI1 was strongly induced by RhEIN3-3 in Arabidopsis protoplasts. What is more, RhEIN3-3 could bind to the promoter of RhGAI1 directly in an electrophoretic mobility shift assay (EMSA). Cell expansion was suppressed in RhGAI1-Δ17-overexpressed Arabidopsis petals and promoted in RhGAI1-silenced rose petals. Moreover, in RhGAI1-silenced petals, the expression of nine cell expansion-related genes was clearly changed, and RhGAI1 can bind to the promoter of RhCesA2 in an EMSA. These results suggested that RhGAI1 was regulated by ethylene at the transcriptional level, and RhGAI1 was a direct target of RhEIN3-3. Also, RhGAI1 was shown to be involved in cell expansion partially through regulating the expression of cell expansion-related genes. Furthermore, RhCesA2 was a direct target of RhGAI1. This work uncovers the transcriptional regulation of RhGAI1 by ethylene and provides a better understanding of how ethylene regulates petal expansion in roses. PMID:24014864

  4. The Tomato (Solanum Lycopersicum cv. Micro-Tom) Natural Genetic Variation Rg1 and the DELLA Mutant Procera Control the Competence Necessary to Form Adventitious Roots and Shoots

    PubMed Central

    Peres, Lázaro Eustáquio Pereira

    2012-01-01

    Despite the wide use of plant regeneration for biotechnological purposes, the signals that allow cells to become competent to assume different fates remain largely unknown. Here, it is demonstrated that the Regeneration1 (Rg1) allele, a natural genetic variation from the tomato wild relative Solanum peruvianum, increases the capacity to form both roots and shoots in vitro; and that the gibberellin constitutive mutant procera (pro) presented the opposite phenotype, reducing organogenesis on either root-inducing medium (RIM) or shoot-inducing medium (SIM). Mutants showing alterations in the formation of specific organs in vitro were the auxin low-sensitivity diageotropica (dgt), the lateral suppresser (ls), and the KNOX-overexpressing Mouse ears (Me). dgt failed to form roots on RIM, Me increased shoot formation on SIM, and the high capacity for in vitro shoot formation of ls contrasted with its recalcitrance to form axillary meristems. Interestingly, Rg1 rescued the in vitro organ formation capacity in proRg1 and dgtRg1 double mutants and the ex vitro low lateral shoot formation in pro and ls. Such epistatic interactions were also confirmed in gene expression and histological analyses conducted in the single and double mutants. Although Me phenocopied the high shoot formation of Rg1 on SIM, it failed to increase rooting on RIM and to rescue the non-branching phenotype of ls. Taken together, these results suggest REGENERATION1 and the DELLA mutant PROCERA as controlling a common competence to assume distinct cell fates, rather than the specific induction of adventitious roots or shoots, which is controlled by DIAGEOTROPICA and MOUSE EARS, respectively. PMID:22915742

  5. Integrated approach based on non-invasive investigations for the structural diagnosis of monuments: the case of the San Francesco della Scarpa Church in Lecce

    NASA Astrophysics Data System (ADS)

    Gizzi, Fabrizio; Leucci, Giovanni; Masini, Nicola; Persico, Raffaele; Quarta, Giovanni

    2015-04-01

    The paper shows the results of a diagnostics survey, based on the ground penetrating radar (GPR), seismic tomography and microtremor horizontal-to-vertical ratio (HVSR) method, to understand the causes of some static instability problems affecting the Church of San Francesco della Scarpa in Lecce (Apulia region, Southern Italy). The prospecting falls within the more general framework of a diagnostic investigation campaign for the restoration of the monument. This study case points out the great effectiveness of the employed diagnostic methods, when used in an integrated way, for detecting cracks and inhomogeneities in the inner structure of masonry building elements [1-2]. With regard to GPR prospecting, in order to better evidence the micro-fracture, a new algorithm, based on a clutter removal technique, has been used. In particular, it removes various unwanted signals such as cross talk, initial ground reflection and antenna ringing. Moreover, seismic tomographies provided complementary information on the mediocre state of conservation of some load bearing structures of the church. Finally, HVSR method allowed to study the relationship between decay patterns, instability problems and seismic response of the monument. Reference [1] Leucci G., Masini N., Persico R., Soldovieri F. 2011. GPR and sonic tomography for structural restoration: the case of the cathedral of Tricarico, Journal of Geophysics and Engineering, 8 (3), 76-92, doi:10.1088/1742-2132/8/3/S08. [2] Calia A., Leucci G., Masini N., Matera L., Persico R., Sileo M., 2012. Integrated prospecting in the Crypt of the Basilica of Saint Nicholas in Bari, Italy. Journal of Geophysics and Engineering, 9(3), 271-281, doi:10.1088/1742-2132/9/3/271.

  6. Renal vascular lesions as a marker of poor prognosis in patients with lupus nephritis. Gruppo Italiano per lo Studio della Nefrite Lupica (GISNEL).

    PubMed

    Banfi, G; Bertani, T; Boeri, V; Faraggiana, T; Mazzucco, G; Monga, G; Sacchi, G

    1991-08-01

    The frequency of renal vascular lesions (RVL) and their relevance in the progression of renal damage were evaluated by the Pathology Group of the "Gruppo Italiano per lo Studio della Nefrite Lupica" (GISNEL). Of 285 patients with lupus nephritis collected from 20 nephrology centers in Italy and classified according to World Health Organization (WHO) criteria, 79 cases (27.7%) with RVL were identified and classified as follows: (1) lupus vasculopathy (n = 27); (2) hemolytic-uremic syndrome/thrombotic thrombocytopenic purpura (HUS/TTP) malignant hypertension-like lesions (n = 24); (3) vasculitis (n = 8); (4) arterio-arteriosclerosis (n = 20). At the time of renal biopsy, patients with RVL had mean serum creatinine levels significantly higher than patients without RVL (201.8 +/- 195.9 mumol/L [2.2 +/- 2.2 mg/dL] v 108.1 +/- 108.0 mumol/L [1.2 +/- 1.2 mg/dL]; P less than 0.01). Hypertension was more frequent in patients with RVL than in those without (68.4% v 30.5%; P less than 0.01). The probability of kidney survival assessed according to the Kaplan-Meier method at 5 and 10 years was, respectively, 74.3% +/- 5.9% and 58.0% +/- 8.9% in patients with RVL, compared with 89.6% +/- 2.7% and 85.9% +/- 3.7% in patients without RVL. However, the two groups did not differ significantly as regards overall survival, the probability of survival at 5 and 10 years being 86.5% +/- 4.5% and 78.8% +/- 6.6% in patients with RVL and 92.2% +/- 2.2% and 83.3% +/- 4.4% in patients without RVL.(ABSTRACT TRUNCATED AT 250 WORDS)

  7. Knockdown of a JmjC domain-containing gene JMJ524 confers altered gibberellin responses by transcriptional regulation of GRAS protein lacking the DELLA domain genes in tomato.

    PubMed

    Li, Jinhua; Yu, Chuying; Wu, Hua; Luo, Zhidan; Ouyang, Bo; Cui, Long; Zhang, Junhong; Ye, Zhibiao

    2015-03-01

    Plants integrate responses to independent hormonal and environmental signals to survive adversity. In particular, the phytohormone gibberellin (GA) regulates a variety of developmental processes and stress responses. In this study, the Jumonji-C (JmjC) domain-containing gene JMJ524 was characterized in tomato. JMJ524 responded to circadian rhythms and was upregulated by GA treatment. Knockdown of JMJ524 by RNAi caused a GA-insensitive dwarf phenotype with shrunken leaves and shortened internodes. However, in these transgenic plants, higher levels of endogenous GAs were detected. A genome-wide gene expression analysis by RNA-seq indicated that the expression levels of two DELLA-like genes, SlGLD1 ('GRAS protein Lacking the DELLA domain') and SlGLD2, were increased in JMJ524-RNAi transgenic plants. Nevertheless, only the overexpression of SlGLD1 in tomato resulted in a GA-insensitive dwarf phenotype, suggesting that SlGLD1 acts as a repressor of GA signalling. This study proposes that JMJ524 is required for stem elongation by altering GA responses, at least partially by regulating SlGLD1. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  8. Application of some integrated non-invasive sensing techniqes for conservation and restoration of the Underground Church and frescoes of S. Maria della Palomba's Sanctuary, Matera (Italy)

    NASA Astrophysics Data System (ADS)

    Lembo, Filiberto; Marino, Francesco P.; Ambrosecchia, Nicola

    2010-05-01

    Santa Maria della Palomba's Sanctuary was built in XV century on a pre-existing medioeval crypt, in a splendid landscape situation, on the front looking south of the ravine on which stands Matera, integrating in a wonderful way underground and sub divo building; in fairly following time one important cycle of frescoes renewed decoration of underground church. In the long run, felt the building into decay, structures and frescoes were flooded and damaged; so that from 1980 were executed important restoration works, realizing ventilation canals under the floor of hypogeic church, in which were incorporated heating pipes, joined to solar thermic panels, wanting to determine the thermo-hygrometric optimum conditions for conservation. Almost thirty years after, willing restorate the frescoes, it was necessary to caracterize completely and objectively physical existing conditions. So was used an integrated mix of some non-invasive sensing techniques: - internal and external high resolution Sanctuary's measurement, using laser scanner 3D, in WebGIS ambient, so as to specify, in particular, whether dimensional data of non accessible parts (thickness of rock-bank, morphology and way of lying down of fracture lines), whether consistence state of frescoes; - thermo-hygrometrical sensing of surfaces, using infrared thermography, during a time of two weeks, in correspondence of many storm, so that to establish the relation between eventual atmospherical conditions variations and changes in conditions of surfaces; - continuous sensing of condition of surfaces, by means of thermo-hygrometrical and temperature sounds; - continuous sensing of operating temperature, by means of a globothermometer; all these tools were linked in a net with a data logger, and informations were transmitted using Web to computer in the office of the Society responsible for the procedure. Remote sensing integrated system proved high liability, allowing many important functions : - to georefer all data

  9. Environmental and climatic conditions at a potential Glacial refugial site of tree species near the Southern Alpine glaciers. New insights from multiproxy sedimentary studies at Lago della Costa (Euganean Hills, Northeastern Italy)

    NASA Astrophysics Data System (ADS)

    Kaltenrieder, Petra; Belis, Claudio A.; Hofstetter, Simone; Ammann, Brigitta; Ravazzi, Cesare; Tinner, Willy

    2009-12-01

    It has been hypothesized that refugia of thermophilous tree species were located in Northern Italy very close to the Alps, though, this hypothesis has yet to be tested thoroughly. In contrast to Central and Southern Italy with its relative wealth of data, only a few fragmentary records are currently available from Northern Italy for the last Glacial (Würm, Weichselian). Our new study site Lago della Costa lies adjacent to the catchment of the megafans of the Alpine forelands and the braided rivers of the Northeastern Po Plain that have so far inhibited the recovery of continuous Glacial and Late-Glacial records. We analyze pollen, plant macrofossils, charcoal and ostracods to reconstruct the vegetation, fire and lake history for the period 33,000-16,000 cal. BP. We compare our data with Glacial records from Southern Europe to discuss similarities and dissimilarities between these potential refugial areas. A comparison with independent paleoclimatic proxies allows to assess potential linkages between environmental and climatic variability. New macrofossil and pollen data at Lago della Costa unambiguously document the local persistence of boreal tree taxa such as Larix decidua and Betula tree species around the study site during the last Glacial. The regular occurrence of pollen of temperate trees in the organic lake sediments (fine-detritus calcareous gyttja) suggests that temperate taxa such as Corylus avellana, Quercus deciduous, Tilia, Ulmus, Fraxinus excelsior, Carpinus, Abies alba and Fagus sylvatica, most likely survived the Last Glacial Maximum (LGM) at favorable sites in the Euganean Hills. The percentage values of temperate trees are comparable with those from Southern Europe (e.g. Monticchio in Southern Italy). We conclude that the Euganean Hills were one of the northernmost refugial areas of temperate taxa in Europe. However, the relative and absolute abundances of pollen of temperate trees are highly variable. Pollen-inferred declines of temperate tree

  10. Evaluation of HACCP Plans of Food Industries: Case Study Conducted by the Servizio di Igiene degli Alimenti e della Nutrizione (Food and Nutrition Health Service) of the Local Health Authority of Foggia, Italy

    PubMed Central

    Panunzio, Michele F.; Antoniciello, Antonietta; Pisano, Alessandra; Rosa, Giovanna

    2007-01-01

    With respect to food safety, many works have studied the effectiveness of self-monitoring plans of food companies, designed using the Hazard Analysis and Critical Control Point (HACCP) method. On the other hand, in-depth research has not been made concerning the adherence of the plans to HACCP standards. During our research, we evaluated 116 self-monitoring plans adopted by food companies located in the territory of the Local Health Authority (LHA) of Foggia, Italy. The general errors (terminology, philosophy and redundancy) and the specific errors (transversal plan, critical limits, hazard specificity, and lack of procedures) were standardized. Concerning the general errors, terminological errors pertain to half the plans examined, 47% include superfluous elements and 60% have repetitive subjects. With regards to the specific errors, 77% of the plans examined contained specific errors. The evaluation has pointed out the lack of comprehension of the HACCP system by the food companies and has allowed the Servizio di Igiene degli Alimenti e della Nutrizione (Food and Nutrition Health Service), in its capacity as a control body, to intervene with the companies in order to improve designing HACCP plans. PMID:17911662

  11. Evaluation of HACCP plans of food industries: case study conducted by the Servizio di Igiene degli Alimenti e della Nutrizione (Food and Nutrition Health Service) of the local health authority of Foggia, Italy.

    PubMed

    Panunzio, Michele F; Antoniciello, Antonietta; Pisano, Alessandra; Rosa, Giovanna

    2007-09-01

    With respect to food safety, many works have studied the effectiveness of self-monitoring plans of food companies, designed using the Hazard Analysis and Critical Control Point (HACCP) method. On the other hand, indepth research has not been made concerning the adherence of the plans to HACCP standards. During our research, we evaluated 116 self-monitoring plans adopted by food companies located in the territory of the Local Health Authority (LHA) of Foggia, Italy. The general errors (terminology, philosophy and redundancy) and the specific errors (transversal plan, critical limits, hazard specificity, and lack of procedures) were standardized. Concerning the general errors, terminological errors pertain to half the plans examined, 47% include superfluous elements and 60% have repetitive subjects. With regards to the specific errors, 77% of the plans examined contained specific errors. The evaluation has pointed out the lack of comprehension of the HACCP system by the food companies and has allowed the Servizio di Igiene degli Alimenti e della Nutrizione (Food and Nutrition Health Service), in its capacity as a control body, to intervene with the companies in order to improve designing HACCP plans.

  12. Independent and interactive effects of DOF affecting germination 1 (DAG1) and the Della proteins GA insensitive (GAI) and Repressor of ga1-3 (RGA) in embryo development and seed germination.

    PubMed

    Boccaccini, Alessandra; Santopolo, Silvia; Capauto, Davide; Lorrai, Riccardo; Minutello, Emanuele; Belcram, Katia; Palauqui, Jean-Cristophe; Costantino, Paolo; Vittorioso, Paola

    2014-07-26

    The transcription factor DOF AFFECTING GERMINATION1 (DAG1) is a repressor of seed germination acting downstream of the master repressor PHYTOCROME INTERACTING FACTOR3-LIKE 5 (PIL5). Among others, PIL5 induces the expression of the genes encoding the two DELLA proteins GA INSENSITIVE 1 (GAI) and REPRESSOR OF ga1-3 (RGA). Based on the properties of gai-t6 and rga28 mutant seeds, we show here that the absence of RGA severely increases dormancy, while lack of GAI only partially compensates RGA inactivation. In addition, the germination properties of the dag1rga28 double mutant are different from those of the dag1 and rga28 single mutants, suggesting that RGA and DAG1 act in independent branches of the PIL5-controlled germination pathway. Surprisingly, the dag1gai-t6 double mutant proved embryo-lethal, suggesting an unexpected involvement of (a possible complex between) DAG1 and GAI in embryo development. Rather than overlapping functions as previously suggested, we show that RGA and GAI play distinct roles in seed germination, and that GAI interacts with DAG1 in embryo development.

  13. Characterization of the procera Tomato Mutant Shows Novel Functions of the SlDELLA Protein in the Control of Flower Morphology, Cell Division and Expansion, and the Auxin-Signaling Pathway during Fruit-Set and Development1[C][W

    PubMed Central

    Carrera, Esther; Ruiz-Rivero, Omar; Peres, Lazaro Eustaquio Pereira; Atares, Alejandro; Garcia-Martinez, Jose Luis

    2012-01-01

    procera (pro) is a tall tomato (Solanum lycopersicum) mutant carrying a point mutation in the GRAS region of the gene encoding SlDELLA, a repressor in the gibberellin (GA) signaling pathway. Consistent with the SlDELLA loss of function, pro plants display a GA-constitutive response phenotype, mimicking wild-type plants treated with GA3. The ovaries from both nonemasculated and emasculated pro flowers had very strong parthenocarpic capacity, associated with enhanced growth of preanthesis ovaries due to more and larger cells. pro parthenocarpy is facultative because seeded fruits were obtained by manual pollination. Most pro pistils had exserted stigmas, thus preventing self-pollination, similar to wild-type pistils treated with GA3 or auxins. However, Style2.1, a gene responsible for long styles in noncultivated tomato, may not control the enhanced style elongation of pro pistils, because its expression was not higher in pro styles and did not increase upon GA3 application. Interestingly, a high percentage of pro flowers had meristic alterations, with one additional petal, sepal, stamen, and carpel at each of the four whorls, respectively, thus unveiling a role of SlDELLA in flower organ development. Microarray analysis showed significant changes in the transcriptome of preanthesis pro ovaries compared with the wild type, indicating that the molecular mechanism underlying the parthenocarpic capacity of pro is complex and that it is mainly associated with changes in the expression of genes involved in GA and auxin pathways. Interestingly, it was found that GA activity modulates the expression of cell division and expansion genes and an auxin signaling gene (tomato AUXIN RESPONSE FACTOR7) during fruit-set. PMID:22942390

  14. Prognostic Impact of Diabetes and Prediabetes on Survival Outcomes in Patients With Chronic Heart Failure: A Post-Hoc Analysis of the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) Trial.

    PubMed

    Dauriz, Marco; Targher, Giovanni; Temporelli, Pier Luigi; Lucci, Donata; Gonzini, Lucio; Nicolosi, Gian Luigi; Marchioli, Roberto; Tognoni, Gianni; Latini, Roberto; Cosmi, Franco; Tavazzi, Luigi; Maggioni, Aldo Pietro

    2017-07-05

    The independent prognostic impact of diabetes mellitus (DM) and prediabetes mellitus (pre-DM) on survival outcomes in patients with chronic heart failure has been investigated in observational registries and randomized, clinical trials, but the results have been often inconclusive or conflicting. We examined the independent prognostic impact of DM and pre-DM on survival outcomes in the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) trial. We assessed the risk of all-cause death and the composite of all-cause death or cardiovascular hospitalization over a median follow-up period of 3.9 years among the 6935 chronic heart failure participants of the GISSI-HF trial, who were stratified by presence of DM (n=2852), pre-DM (n=2013), and non-DM (n=2070) at baseline. Compared with non-DM patients, those with DM had remarkably higher incidence rates of all-cause death (34.5% versus 24.6%) and the composite end point (63.6% versus 54.7%). Conversely, both event rates were similar between non-DM patients and those with pre-DM. Cox regression analysis showed that DM, but not pre-DM, was associated with an increased risk of all-cause death (adjusted hazard ratio, 1.43; 95% CI, 1.28-1.60) and of the composite end point (adjusted hazard ratio, 1.23; 95% CI, 1.13-1.32), independently of established risk factors. In the DM subgroup, higher hemoglobin A1c was also independently associated with increased risk of both study outcomes (all-cause death: adjusted hazard ratio, 1.21; 95% CI, 1.02-1.43; and composite end point: adjusted hazard ratio, 1.14; 95% CI, 1.01-1.29, respectively). Presence of DM was independently associated with poor long-term survival outcomes in patients with chronic heart failure. URL: http://www.clinicaltrials.gov. Unique identifier: NCT00336336. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

  15. Una ricerca sul bilinguismo precoce italo-inglese (Research on Early Italian-English Bilingualism).

    ERIC Educational Resources Information Center

    Taeschner, Traute; And Others

    1978-01-01

    The purpose of this study was to attempt to verify the theory of Taeschner and Volterra (1976) that bilingual children pass through three distinct phases while becoming perfectly bilingual. The 12 subjects were English-Italian bilingual children between the ages of 1.6 and 4.6. (CFM)

  16. Gli astrofili nell'era di Internet: nuove prospettive di ricerca

    NASA Astrophysics Data System (ADS)

    Masi, Gianluca

    2004-08-01

    The coming of the Internet era has produced an important revolution in the world of amateur astronomy, comparable to that following the introduction of CCD cameras. The possibility to join international campaigns, sharing data in real time and fine tuning the observing session opens new research perspectives previously unknown. The author discusses some of them, based on his own experience with some recent astronomical events in the field of variable stars, minor bodies and GRB.

  17. [Ricerca storica sul contributo di Cristina Trivulzio di Belgiojoso all'assistenza infermieristica].

    PubMed

    Bertozzi, Simona; Di Mauro, Stefania; Manzoni, Edoardo

    2016-01-01

    The aim of this historical research project is to examine the contribution of Cristina Trivulzio Princess of Belgiojoso to the development of the nursing organisation in Italy. Specifically, the analysis focuses on the period of the Roman Republic, as in 1849 Cristina Trivulzio (Princess of Belgiojoso) was one of the person in charge of the service of caring and rescuing of the injured. For this reason, nineteen volumes were analysed out of the one hundred twenty-nine volumes found in five Italian historical archives. All documentary sources were evaluated accordingly to the Chabod historical research method (1999), while for their critical interpretation a scheme of analysis was created. As a result, five topics clearly emerged from the data collected: organisation, health politics, training, research and nursing. To sum up, this research reveals that the contributions of Cristina Trivulzio are so relevant that she may be counted among the founders of the italian nursing organisation.

  18. Una ricerca sul bilinguismo precoce italo-inglese (Research on Early Italian-English Bilingualism).

    ERIC Educational Resources Information Center

    Taeschner, Traute; And Others

    1978-01-01

    The purpose of this study was to attempt to verify the theory of Taeschner and Volterra (1976) that bilingual children pass through three distinct phases while becoming perfectly bilingual. The 12 subjects were English-Italian bilingual children between the ages of 1.6 and 4.6. (CFM)

  19. Non-Poisson Processes: Regression to Equilibrium Versus Equilibrium Correlation Functions

    DTIC Science & Technology

    2007-11-02

    76203-1427, USA cDipartimento di Fisica dell’Università di Pisa and INFM, Via Buonarroti 2, 56127 Pisa, Italy dIstituto dei Processi Chimico Fisici del...CNR, Area della Ricerca di Pisa, Via G. Moruzzi 1, 56124 Pisa, Italy eDipartimento di Fisica and INFM, Center for Statistical Mechanics and Complexity...dichotomous fluctuations that generate super-diffusion. We adopt the Liouville perspective and with it a quantum-like approach based on splitting the density

  20. Non-Poisson Dichotomous Noise: Higher-Order Correlation Functions and Aging

    DTIC Science & Technology

    2004-10-26

    West5 1INFM, Unità di Como, Via Valleggio 11, 22100 Como, Italy and Istituto di Linguistica Computazionale del CNR, Area della Ricerca di Pisa, Via...walk (CTRW) formalism and the adoption of a Liouville-like ap- proach to the dynamics [20]. The DF assumption is not ex- plictly made by Cáceres [15...whether the density and Liouville-like formalism are compatible with the emer- gence of these properties. II. FOUR-TIME CORRELATION FUNCTION In this

  1. Correlation Function and Generalized Master Equation of Arbitrary Age

    DTIC Science & Technology

    2007-11-02

    P.O. Box 311427, Denton, Texas 76203-1427, USA 3Dipartimento di Fisica dell’Università di Pisa and INFM, Via Buonarroti 2, 56127 Pisa, Italy 4Istituto...dei Processi Chimico Fisici del CNR Area della Ricerca di Pisa, Via G. Moruzzi 1, 56124 Pisa, Italy 5Dipartimento di Fisica and Istituto dei Sistemi...represents the probability of finding the walker at time t in the ith site. states. K is a transition matrix between the sites and Fstd is the memory kernel

  2. Orientamento della prima fase della moschea al-Aqşā di Gerusalemme

    NASA Astrophysics Data System (ADS)

    Di Cesare, Michelina

    2017-07-01

    A new interpretation of the archaeological data regarding the first of the three pre-Crusader structural phases of al-Aqşā mosque in Jerusalem (Aqşā I) is proposed. It suggests that the building had an astronomical orientation like other 7th-century and early 8th-century mosques. Thus, Aqşā I would have been oriented towards the East rather than the South, as believed so far. This hypothesis would allow to solve the anomalies of the plan of Aqşā I. Indeed, by identifying the eastern wall rather than the southern as the qiblī wall, the aisles would not result perpendicular but parallel to it and running along the long side, as usual in Umayyad mosques. Consequently, the precocious appearance of the transept in Aqşā II would be due to the re-orientation of the previous structure.

  3. System of Indexes and Indicators for the Quality Evaluation of HACCP Plans based on the Results of the Official Controls conducted by the Servizio di Igiene degli Alimenti della Nutrizione (Food and Nutrition Health Service) of the Local Health Authority of Foggia, Italy

    PubMed Central

    Panunzio, Michele F.; Antoniciello, Antonietta; Pisano, Alessandra

    2007-01-01

    Within the realm of evaluating self-monitoring plans, developed based on the Hazard Analysis and Critical Control Points (HACCP) method and adopted by food companies, little research has been done concerning the quality of the plans. The Servizio di Igiene degli Alimenti e della Nutrizione (Food and Nutrition Health Service) of the Local Health Authority of Foggia, Italy, has conducted research with the aim to adopt a system of indexes and indicators for the qualitative evaluation of HACCP plans. The critical areas considered were the following: simplicity, specificity, feasibility and adherence. During the period from January 2004 to June 2005, the evaluation grid was used in examining 250 HACCP self-monitoring plans of food companies. For the analysis of the determining factor four groups were considered, with reference to HACCP self-monitoring plans designed: group 1 - with the aid of a qualified team; group 2 - with the aid of an unqualified team; group 3 - with the aid of an unqualified expert; group 4 – without the aid of an expert. The mean values of the measures elaborated decrease towards insufficiency moving from group 1 to group 4. In particular, collaboration by teams of unqualified experts brought about drafting unacceptable HACCP plans on the levels of specificity and adherence, with respect to the HACCP method. The method proposed of the analysis of the indexes and indicators beginning with an evaluation sheet can also help the individual company to better adjust contribution by internal or external professionals to the company. PMID:17431313

  4. Nursing diagnoses and theoretical frameworks in neonatal units: a literature review.

    PubMed

    Di Sarra, Luca; D'Agostino, Fabio; Cocchieri, Antonello; Vellone, Ercole; Zega, Maurizio; Alvaro, Rosaria

    2016-01-01

    Obiettivo: Identificare le diagnosi infermieristiche ed i quadri teorici utilizzati nelle unità neonatali attraverso una revisione della letteratura. Metodo: Per effettuare questo studio sono stati usati database come Cinahl, Medline e Lilacs. I descrittori usati sono: "Diagnosi infermieristica" AND "Modelli, Infermieristici" OR "Teoria infermieristica" AND "Infante" OR "Neonato". La ricerca era limitata agli arti- coli pubblicati dal 2000 al novembre 2013. Venivano selezionati soltanto gli studi scritti in inglese, spagnolo, portoghese e italiano. Risultati: Nella revisione della letteratura sono state identificate due tassonomie e sei impor- tanti quadri teorici. Le diagnosi infermieristiche più frequentemente individuate sono: intol- leranza alle attività, ridotta ventilazione spontanea, modello di respirazione inefficace, rischio di aspirazione, ritardo nella crescita e nello sviluppo, allattamento al seno inefficace, modello di alimentazione infantile inefficace, ipertermia/ipotermia, rischio di infezione, alterazione dell’integrità cutanea, interruzione dei processi familiari, rischio di compromissione della genitorialità, rischio di riduzione dell’attaccamento. Sono state identificate diagnosi appli- cabili alla sfera psico-sociale genitoriale che consentivano una valutazione integrale del neonato, compresa la famiglia. Conclusioni: Le diagnosi infermieristiche consentono agli infermieri che lavorano nelle unità neonatali l’opportunità di gestire efficacemente il processo assistenziale, nonché la disponibilità dei dati necessari per il continuo miglioramento della qualità nella cura infer- mieristica. L'utilizzo di un unico modello o di più modelli di riferimento costituisce un modo per aiutare l'agire professionale.

  5. Risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation: Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) Trials.

    PubMed

    Abdul-Rahim, Azmil H; Perez, Ana-Cristina; Fulton, Rachael L; Jhund, Pardeep S; Latini, Roberto; Tognoni, Gianni; Wikstrand, John; Kjekshus, John; Lip, Gregory Y H; Maggioni, Aldo P; Tavazzi, Luigi; Lees, Kennedy R; McMurray, John J V

    2015-04-28

    Our aim was to describe the incidence and predictors of stroke in patients who have heart failure without atrial fibrillation (AF). We pooled 2 contemporary heart failure trials, the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza cardiaca-Heart Failure trial (GISSI-HF). Of the 9585 total patients, 6054 did not have AF. Stroke occurred in 165 patients (4.7%) with AF and in 206 patients (3.4%) without AF (rates 16.8/1000 patient-years and 11.1/1000 patient-years, respectively). Using Cox proportional-hazards models, we identified the following independent predictors of stroke in patients without AF (ranked by χ(2) value): age (hazard ratio, 1.34; 95% confidence interval, 1.18-1.63 per 10 years), New York Heart Association class (1.60, 1.21-2.12 class III/IV versus II), diabetes mellitus treated with insulin (1.87, 1.22-2.88), body mass index (0.74, 0.60-0.91 per 5 kg/m(2) up to 30), and previous stroke (1.81, 1.19-2.74). N-terminal pro B-type natriuretic peptide (available in 2632 patients) was also an independent predictor of stroke (hazard ratio, 1.31; 1.11-1.57 per log unit) when added to this model. With the use of a risk score formulated from these predictors, we found that patients in the upper third of risk had a rate of stroke that approximated the risk in patients with AF. A small number of demographic and clinical variables identified a subset of patients who have heart failure without AF at a high risk of stroke. © 2015 American Heart Association, Inc.

  6. Red blood cell oleic acid levels reflect olive oil intake while omega-3 levels reflect fish intake and the use of omega-3 acid ethyl esters: The Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Heart Failure trial.

    PubMed

    Harris, William S; Masson, Serge; Barlera, Simona; Milani, Valentina; Pileggi, Silvana; Franzosi, Maria Grazia; Marchioli, Roberto; Tognoni, Gianni; Tavazzi, Luigi; Latini, Roberto

    2016-09-01

    The Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Heart Failure (GISSI-HF) study reported benefits of n-3 fatty acid (FA) treatment on cardiovascular (CV) events, but the effects of treatment on a putative CV disease risk factor, the red blood cell (RBC) n-3 FA level (the omega-3 index), have not been examined in this context. We hypothesized that treatment with prescription omega-3 acid ethyl esters (O3AEE) would increase the omega-3 index to the proposed cardioprotective value of 8%. RBCs were collected from a subset of patients participating in the GISSI-HF study (n=461 out of 6975 randomized), at baseline and after 3 months of treatment with either an olive oil placebo or O3AEE (1 g/d). RBC FA levels were expressed as a percentage of total FA. Patients also reported their typical olive oil and fish intakes. RBC oleic acid levels were directly correlated with reported frequency of olive oil consumption, and the omega-3 index was correlated with reported fish intake (P for trends <0.001 for both). After treatment, the omega-3 index increased from 4.8±1.7% to 6.7±1.9% but was unchanged in the placebo group (4.7±1.7 to 4.8±1.5%) (P<.0001 for changes between groups). At 3 months, more patients reached the proposed target omega-3 index level of 8%-12% in the treated vs placebo group (22.6% vs. 1.3%, P<.0001), however, what omega-3 index levels were ultimately achieved after four years in this trial are unknown. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Callisto III e la Cometa di Halley: la ricerca di Johan Stein SJ tra leggenda e storia

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    The Dutch Jesuit astronomer Johan Stein published in 1909 a text about the legend on a papal bull of Pope Callixtus III against the comet of 1456. This comet happened to be the Halley's one. The original documents, either chronicles and observations, and coeval testimonies are deeply investigated by Stein and the falsity of that legend is clearly demonstrated. In the occasion of the 200 years of the restoration of the Societas Jesu made in 1814 by Pope Pius VII an Italian edition of the full text of Johan Stein is here presented.

  8. Misura dell'azimut della Piramide Cestia col Sole

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2016-05-01

    The Pyramid of Caius Cestius in Rome has been built in 330 days in 12 b.C. The instants when the Sun rays are grazing to the East face of the Pyramid have been observed in different days, writing a table of solar azimut and altitudes. Extrapolating for zero altitude, the azimut 201.8°±1.4° of the Pyramid is obtained; it corresponds to the azimut 204.27° of the Sun when the shadow of the lightning rod divides in two equal parts the North face.

  9. Algoritmi per il calcolo dell'epatta della Luna

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2016-05-01

    On the sides of the chair of St. Hyppolitus in the Vatican Libray there is a series of 112 epacts, used for calculating the date of Christian Easter valid for 112 years from 222 AD. The algorithm of octaëteris or 8 civil (julian) years=99 lunar months and a correction of three days each 16 years or one day each 5, 5, 6 years are discussed. Four complete solar cycles (28 years), after which the sequence of the day of the week are repeating, are included in 112 years as well as 7 groups of 16 years; 112 is the minimum common multiple between the double octaëteris (16 years) and the solar cycle (28).

  10. Allineamento della Basilica di san Pietro col Sole

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino; Regoli, Irene

    2017-06-01

    The obelisk of St Peter in Vatican is not centered with the Basilica's axis; its alignment is measured with the Sun azimuth as 88°59'±1', consistent with the rising azimuth of the ecclesiastic equinox, 21 march 315.

  11. Il fenomeno della "goccia nera" e l'astigmatismo

    NASA Astrophysics Data System (ADS)

    Horn D'Arturo, Guido

    2004-03-01

    The Venus transit on the Solar disc was for the first time observed in 1639, using "modern" instruments, by Gassendi. Yet since the following transit, an effect was perceived which modified Venus and Sun profiles at the moments of the first and second visual contact between the two celestial bodies. This effect was called "gutta nigra", i.e. black drop. Horn d'Arturo was widely interested in studies on the vision and on its effects on astronomical observations. In the following paper, he suggested what probably was the first correct explanation of the black drop effect. As stated on the Dictionary of Scientific Biography (ad vocem), Horn "clarified the effect on vision, especially in the astigmatic eye, of the suture of the eye lens and the formation of the so-called black drop".

  12. Opera in Kindergarten: "La Principessa della sacco di carta"

    ERIC Educational Resources Information Center

    Honeck, Ellen; Jones, Shannon

    2009-01-01

    When designing curriculum, the unique characteristics of young, gifted students must be carefully considered. Many have a highly defined sense of justice or fairness, a precocious ability to manipulate language or number systems, a need to see the connections between learning experiences, a heightened curiosity, and an ability to conceive a…

  13. The fabbrica della penicillina in postwar Italy: an institutionalist approach.

    PubMed

    Taroni, Francesco

    2014-01-01

    This paper focuses on the motives and long-term effects of the momentous decision to build a world-class biomedical research laboratory, the International Center for Chemical Microbiology, at the Istituto Superiore di Sanità in Rome, rather than develop domestic production of penicillin to meet the needs of a destitute postwar Italy. An institutionalist approach will provide a richer vision of the intersections of scientific and national political history in postwar Italy and the Cold War. The Center failed in its modernising mission due to an insular mentality producing an 'enclosure effect' against the State, the healthcare system and the pharmaceutical industry. The absence of a scientific base together with an economic policy of 'liberal protectionism' that placed premiums on import tariffs and the licensing of foreign products explains the path dependency of the pharmaceutical industry during the postwar years and its demise in the 1960s.

  14. Il volto della Luna da Plutarco a Newton. Storia di una teoria ellenistica della gravità

    NASA Astrophysics Data System (ADS)

    Cappi, Alberto

    2013-03-01

    In his dialogue "De Facie quae in Orbe Lunae apparet", Plutarch includes a discussion on a non-Aristotelian theory of gravity. I describe how this theory could be developed during the Hellenistic period and its influence on the cosmological debate along the centuries until the beginning of modern science. (Text in Italian)

  15. [Cross-sectional study on the determinants of work stress for nurses and intention of leaving the profession].

    PubMed

    Romano, Marina; Festini, Filippo; Bronner, Leonardo

    2015-01-01

    INTRODUZIONE. Lo stress occupazionale è una delle principali cause di malattie professionali e di assenze da lavoro e genera costi sanitari e sociali molto elevati; la comprensione del problema è stata l'obiet- tivo di numerosi studi. Monitorare lo stress negli infermieri può essere uno strumento per chi ha la responsabilità della gestione delle risorse umane nel sistema sanitario. La ricerca infermieristica italiana si è occupata solo marginalmente di stress lavorativo infermieristico. Gli obiettivi di questo studio sono dunque: stimare la prevalenza di stress tra gli infermieri di tre ospedali, in modo da disporre di dati epidemiologici per valutare la necessità di interventi di prevenzione e di trattamento del fenomeno; analizzare eventuali fattori di rischio e fattori protettivi in modo da progettare interventi preventivi mirati.

  16. PREFACE: Young Researcher Meeting in Rome 2012

    NASA Astrophysics Data System (ADS)

    Agostini, Fabio; Cattani, Giordano; Mazzaferro, Luca; Migliaccio, Marina; Pietrobon, Davide; Ricci Pacifici, Daniel; Stellato, Francesco; Veneziani, Marcella

    2012-10-01

    Conference logo At its third edition, the Young Researcher Meeting in Rome (YRMR) proves to be a growing event in the Italian scientific panorama. The high-quality content of the abstracts submitted to the scientific committee resulted in an exciting conference, held, for the second time, at the University of Rome 'Tor Vergata' on 20 January 2012. A busy schedule covered a large variety of cutting-edge science topics: fundamental interactions, particle physics, cosmology, astrophysics, condensed matter and biomedical physics. The broad range of the subjects discussed is the distinctive feature of the YRMR, a meeting aimed at enhancing the synergy among complementary branches of science by stimulating a fruitful exchange between theoretical, experimental and computational physics. Promoting collaborations between PhD students, postdoctoral fellows and young researchers creates a solid scientific network with an open-minded approach to discovery. In this volume, we collect the contributions that have been presented both in the form of talks and of posters. YRMR Organising and Editorial Committee Fabio Agostini (fabio.agostini@roma2.infn.it) Dipartimento di Fisica, Università di Roma 'Tor Vergata' Via della Ricerca Scientifica 1, 00133 Roma Italy Giordano Cattani (giordano.cattani@roma2.infn.it) Dipartimento di Fisica, Università di Roma 'Tor Vergata' INFN sezione di Roma 'Tor Vergata' Via della Ricerca Scientifica 1, 00133 Roma Italy Luca Mazzaferro (luca.mazzaferro@roma2.infn.it) Dipartimento di Fisica, Università di Roma 'Tor Vergata' INFN sezione di Roma 'Tor Vergata' Via della Ricerca Scientifica 1, 00133 Roma Italy Marina Migliaccio (migliaccio@ifca.unican.es) Instituto de Fisica de Cantabria, Edificio Juan Jorda, Avenida de los Castros, E-39005 Santander, Cantabria Spain Davide Pietrobon (davide.pietrobon@jpl.nasa.gov) Jet Propulsion Laboratory - California Institute of Technology 4800 Oak Grove Drive 169-237 91109 Pasadena, CA USA Daniel Ricci Pacifici

  17. Power supply distribution system for calorimeters at the LHC beyond the nominal luminosity

    NASA Astrophysics Data System (ADS)

    Tenti, P.; Spiazzi, G.; Buso, S.; Riva, M.; Maranesi, P.; Belloni, F.; Cova, P.; Menozzi, R.; Delmonte, N.; Bernardoni, M.; Iannuzzo, F.; Busatto, G.; Porzio, A.; Velardi, F.; Lanza, A.; Citterio, M.; Meroni, C.

    2011-06-01

    This paper investigates the use of switching converters for the power supply distribution to calorimeters in the ATLAS experiment when the Large Hadron Collider (LHC) will be upgraded beyond the nominal luminosity. Due to the highly hostile environment the converters must operate in, all the main aspects are considered in the investigation, from the selection of the switching converter topologies to the thermal analysis of components and PCBs, with attention to reliability issues of power devices subject to ionizing radiations. The analysis focuses on the particular, but crucial, case of the power supplies for calorimeters, though several outcomes of the research can profitably be applied to other detectors like muon chambers. Research co-funded by the Italian Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR) and the Istituto Nazionale di Fisica Nucleare (INFN), under the PRIN 2007 program.

  18. Typical and atypical lymphatic flows in breast carcinoma.

    PubMed

    Pasta, Vittorio; Monteleone, Francesco; D'Orazi, Valerio; Del Vecchio, Luca; Sottile, Daniela; Iacobelli, Silvia; Monti, Massimo

    2015-01-01

    La pratica, universalmente riconosciuta, della ricerca e biopsia del linfonodo sentinella nella stadiazione dei tumori ha evidenziato una serie di situazioni anatomiche e fisiologiche che hanno consentito una più approfondita conoscenza del comportamento del flusso linfatico nel soggetto sano e nel paziente affetto da neoplasia. In particolar modo abbiamo concentrato la nostra attenzione sulle pazienti sottoposte a ricerca linfoscintigrafica del linfonodo sentinella in vista di interventi chirurgici per carcinoma mammario; abbiamo valutato statisticamente la sede in cui è stato reperito il LS e nell’eventualità di drenaggio in sedi anomale il percorso del flusso linfatico. Si è fatto riferimento, per questo studio, alla casistica del Dipartimento di Scienze Chirurgiche dell’Università La Sapienza di Roma maturata negli ultimi 2 anni. Lo scopo del nostro studio è stato quello di valutare statisticamente la sede del linfonodo sentinella, le possibilità di flussi linfatici in direzione non usuale e in questi casi dove, quando e perché. Ne sono emersi riscontri degni di analisi critica e considerazioni oggetto del presente lavoro.

  19. [National epidemiological surveillance systems of mesothelioma cases].

    PubMed

    Ferrante, Pierpaolo; Binazzi, Alessandra; Branchi, Claudia; Marinaccio, Alessandro

    2016-01-01

    INTRODUZIONE: sebbene la relazione causale tra esposizione ad amianto e malattie neoplastiche sia ben nota, in molti Paesi il consumo del materiale è ancora rilevante e crescente. A causa della lunga latenza, nei Paesi dove è stato bandito (come in Italia) è oggi in corso un'epidemia di malattie correlate ad amianto. OBIETTIVI: descrivere i sistemi di sorveglianza dei mesoteliomi attivi nel mondo mediante un'analisi comparativa. è stata condotta una revisione bibliografica della letteratura disponibile sui sistemi di sorveglianza epidemiologica dei mesoteliomi attivi nel mondo, comparando metodi e risultati disponibili. RISULTATI: sistemi di ricerca dei casi incidenti e di analisi anamnestica dei soggetti ammalati sono attivi solo in Italia, Francia e Corea del Sud. I Paesi presso i quali sono attivi sistemi di rilevazione e controllo dei casi incidenti di mesotelioma sono quelli in cui vige il bando dell'amianto e che hanno sperimentato consumi rilevanti in passato. Non sono stati istituiti sistemi epidemiologici di sorveglianza in molti Paesi dove il consumo di amianto è ancora importante (inclusi Russia, Cina, India e Brasile). CONCLUSIONI: si conferma l'importanza dei sistemi di sorveglianza epidemiologica dei mesoteliomi per la sanità pubblica, il sostegno alle politiche di welfare e la prevenzione dei rischi. Lo sviluppo di progetti per tendere a una maggiore uniformità nei metodi di ricerca dei casi, di classificazione delle diagnosi e dell'esposizione e nelle tecniche di analisi dei dati potrebbe consentire una maggiore fruibilità dei dati aggregati. La disponibilità di dati internazionali confrontabili può essere di stimolo all'adozione di provvedimenti di bando internazionale.

  20. Scienza dei servizi

    NASA Astrophysics Data System (ADS)

    Cavenago, Dario; Mezzanzanica, Mario

    I servizi sono oramai centrali nella vita sociale di ogni Paese. L'aspettativa di ogni attore sociale, sia esso cittadino/utente e/o istituzione, è quella di ricevere da uno scambio che ha alla base un servizio un contributo che si caratterizza per una qualità intrinseca. Il mantenimento di tale promessa richiede all'azienda erogatrice un forte coinvolgimento, nel disegno del servizio, degli utenti ed una capacità di gestione della conoscenza; ciò è particolarmente significativo per quei servizi che si caratterizzano per una forte personalizzazione o complessità progettuale. Disegnare un servizio, metterlo in produzione e gestirne l'erogazione ha una complessità variabile in base al grado di coinvolgimento dei destinati ed alle dimensioni critiche che esprimono le condizioni di fattibilità di un servizio di qualità appropriato alle attese degli utilizzatori. Ugualmente la globalizzazione dell'economia e la scarsità delle risorse ha portato l'attenzione, ai fini della sostenibilità delle condizioni sopra richiamate, di una ricerca di modelli e strumenti che permettano una valutazione e una standardizzazione dei processi di produzione ed erogazione secondo condizioni di economicità. Tali primi e sintetici elementi hanno condotto diversi attori istituzionali, grandi imprese ed università attraverso i loro centri di ricerca, ad una azione di riflessione sul grado di "ingegnerizzazione" dei processi sottesi alla erogazione dei servizi ed in particolare ai servizi che attuano le politiche dei grandi settori di base dell'economia di una Nazione: educazione, sanità, sociale, sviluppo infrastrutture ecc.

  1. [The person inside the patient: a qualitative research on the dignity of people assisted in hospital].

    PubMed

    Giorgi, Sara; Bonfandini, Sara; Rossini, Silvia

    2016-01-01

    Scopo: la dignità della persona assistita e il rispetto per quest’ultima sono aspetti imprescindibili della professione infermieristica. Sviluppare un sapere esperto è possibile qualora il professionista sanitario interpreti il proprio ruolo come soggetto coinvolto in maniera empatica. Lo scopo di questo studio è capire cosa influenzi la dignità degli assistiti attraverso i loro vissuti al fine di comprendere come offrire assistenza umanizzante. Metodo: l’indagine è stata condotta nell’ospedale di Valcamonica, su un campione di 20 soggetti, qui ricoverati nell’agosto 2015, corrispondenti a predefiniti criteri d’inclusione. Come strumento è stata utilizzata un’intervista semistrutturata attraverso domande funzionali al quesito di ricerca. Risultati: la dignità è considerata una caratteristica intrinseca in ogni essere umano. La maggior parte degli intervistati percepisce la dignità come mantenuta, durante il ricovero ospedaliero. I fattori che possono influenzarla sono riassumibili in tre categorie: fattori legati al comportamento del personale sanitario, all’ambiente ospedaliero ed alle condizioni dell’assistito. Conclusioni: la dignità è un concetto ad oggi astratto e nebuloso; ciò nonostante è qualcosa di cui ogni essere umano ha consapevolezza e sa quanto sia importante salvaguardarla. L’ambiente ospedaliero di per sé alienante e le condizioni di fragilità e dipendenza che spesso accompagnano la malattia possono ledere la dignità. Un comportamento corretto e disponibile da parte di chi assiste è ciò che più aiuta a mantenerla; l’approccio clinico che tiene conto solo della malattia e non dell’individualità della persona è inadeguato per ogni tipologia di assistito.

  2. Elaborare in sardo, elaborare in italiano. Una ricerca nella scuola media (Uses of Sardinian and Italian: Research in the Junior High School).

    ERIC Educational Resources Information Center

    Pinto, Maria Antonietta; Migaleddu, Maria Vittoria

    1989-01-01

    Presents a historic overview and analysis of the Sardinian language (actually a system of dialects), and defines diglossia and bilingualism. A discussion focuses on research conducted in two junior high schools to determine the differences in linguistic behavior in two contrasting situations (village and city) in regard to Sardinian and Italian.…

  3. Elaborare in sardo, elaborare in italiano. Una ricerca nella scuola media (Uses of Sardinian and Italian: Research in the Junior High School).

    ERIC Educational Resources Information Center

    Pinto, Maria Antonietta; Migaleddu, Maria Vittoria

    1989-01-01

    Presents a historic overview and analysis of the Sardinian language (actually a system of dialects), and defines diglossia and bilingualism. A discussion focuses on research conducted in two junior high schools to determine the differences in linguistic behavior in two contrasting situations (village and city) in regard to Sardinian and Italian.…

  4. Three models intercomparison for Quantitative Precipitation Forecast over Calabria

    NASA Astrophysics Data System (ADS)

    Federico, S.; Avolio, E.; Bellecci, C.; Colacino, M.; Lavagnini, A.; Accadia, C.; Mariani, S.; Casaioli, M.

    2004-11-01

    In the framework of the National Project “Sviluppo di distretti industriali per le Osservazioni della Terra” (Development of Industrial Districts for Earth Observations) funded by MIUR (Ministero dell'Università e della Ricerca Scientifica --Italian Ministry of the University and Scientific Research) two operational mesoscale models were set-up for Calabria, the southernmost tip of the Italian peninsula. Models are RAMS (Regional Atmospheric Modeling System) and MM5 (Mesoscale Modeling 5) that are run every day at Crati scrl to produce weather forecast over Calabria (http://www.crati.it). This paper reports model intercomparison for Quantitative Precipitation Forecast evaluated for a 20 month period from 1th October 2000 to 31th May 2002. In addition to RAMS and MM5 outputs, QBOLAM rainfall fields are available for the period selected and included in the comparison. This model runs operationally at “Agenzia per la Protezione dell'Ambiente e per i Servizi Tecnici”. Forecasts are verified comparing models outputs with raingauge data recorded by the regional meteorological network, which has 75 raingauges. Large-scale forcing is the same for all models considered and differences are due to physical/numerical parameterizations and horizontal resolutions. QPFs show differences between models. Largest differences are for BIA compared to the other considered scores. Performances decrease with increasing forecast time for RAMS and MM5, whilst QBOLAM scores better for second day forecast.

  5. Lo Gnomone Clementino Astronomia Meridiana in Basilica

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2014-05-01

    Costruito per chiara volontà del papa 70 anni dopo il caso Galileo, lo Gnomone Clementino è un grande telescopio solare che non fa uso di lenti a 92 anni dall’invenzione del cannocchiale. Queste due caratteristiche basterebbero da sole a giustificare l’interesse verso questo strumento. L’astronomia meridiana è alla base dell’astrometria e dell’astrofisica moderna. Lo Gnomone Clementino sta oggi all’astronomia, come il veliero “Amerigo Vespucci” sta alla Marina Italiana. E’ possibile svolgere ogni genere di osservazione e studio su questo strumento, e dal 2002 vi tengo lezioni teorico-pratiche del corso di Storia dell’Astronomia e La Terra nel Sistema Solare della Sapienza, Università di Roma, Facoltà di Lettere e Filosofia. Questo testo aggiunge alcuni tasselli alla ricerca storica sulla meridiana, appoggiandosi, com’è naturale, sulle spalle di giganti che mi hanno preceduto in questi studi. In particolare la misura dell’azimut della meridiana, ed il suo inquadramento tra gli strumenti simili ed alcuni studi di astrometria sui dati del 1701-1703 di Bianchini, che sono apparsi fin’ora soltanto su riviste specializzate ed in Inglese vengono qui proposti in Italiano e semplificati, per valorizzare sempre più questa straordinaria opera d’arte e di scienza.

  6. Plasma viscosity: a potential predictor of both medical treatment response and clinical stage of ulcerative colitis.

    PubMed

    Tolga, Yakar; Mansur, Cosar Arif; Savas, Gokturk Hu Seyin; Gulhan, Unler Kanat Ayse; Alper, Parlakgumus; Ilknur, Kozanoglu; Ender, Serin

    2016-01-01

    La colite ulcerosa (UC) è una delle maggiori forme di colonpatia infiammatoria cronica recidivante. La capacità di identificare tipo, gravità e sensibilità alla terapia su parametri di laboratorio è da tempo oggetto di ricerca degli studi clinici. Lo scopo di questo studio è quello di accertare la relazione tra la viscosità del plasma (PV), l’attività della malattia e la risposta al trattamento medico. Lo studio si è svolto su 105 pazienti con UC e 42 volontari sani. I prelievi di sangue sono stati utilizzati per valutare la viscosità del plasma (PV), la velocità di eritrosedimentazione (ESR), la proteina C-reattiva ultrasensibile (hs-CRP), il D-dimero e il fibrinogeno. I pazienti con UC sono stati raggruppati in relazione al grado di attività flogistica (cioè 59 attivi e 46 in remissione). La PV è risultata più elevata in quelli con UC attiva rispetto a quella dei soggetti in remissione o nei soggetti sani. È risultata significativamente più elevata sia nei casi di UC refrattaria al trattamento steroideo rispetto a quelli sensibili (p< 0.001), e nelle UC rafrattarie alla ciclosrporina rispetto a quelli sensibili (p= 0.003). Con l’aumento della PV nei pazienti affetti da UC sono risultati significativamente associati il punteggio del SCCAI (Increased Simple Clinical Colitis Activity Index), dell’EGS (Endoscopic Grading Scale) e del HAD (Histological Disease Activity (HAD). Si conclude che la PV è un marker utile per la previsione di sensibilità al trattamento sterorideo e con ciclosporina nei pazienti con UC attiva. Potrebbe essere rimpiazzata dalla ESR e dalla hs-CRP come misura della risposta in fase acuta in quanto sufficientemente sensibile. Questi risultati possono essere utili per l’identificazione dei pazienti con UC attiva da destinare alla colectomia.

  7. Il problema della scelta e della continuita della lingua straniera nella scuola dell'obbligo (Problems of Choice and Continuity of a Foreign Language in Elementary and Junior High School).

    ERIC Educational Resources Information Center

    Gotti, Maurizio

    1987-01-01

    Discusses two current problems with foreign language study in Italy: (1) Students are frequently unable to study English, the most popular language, because of a lack of qualified English teachers; and (2) Students sometimes cannot continue studying in junior high school the language they began in elementary school. (CFM)

  8. Il problema della scelta e della continuita della lingua straniera nella scuola dell'obbligo (Problems of Choice and Continuity of a Foreign Language in Elementary and Junior High School).

    ERIC Educational Resources Information Center

    Gotti, Maurizio

    1987-01-01

    Discusses two current problems with foreign language study in Italy: (1) Students are frequently unable to study English, the most popular language, because of a lack of qualified English teachers; and (2) Students sometimes cannot continue studying in junior high school the language they began in elementary school. (CFM)

  9. [Linee guida flebo-linfologiche SIF-SICVE 2016 della Società Italiana di Flebologia e della Società Italiana di Chirurgia Vascolare ed Endovascolare].

    PubMed

    Ebner, Heinrich; Stillo, Francesco; Lanza, Gaetano; Mangialardi, Nicola; Agus, Giovanni B; Apperti, Marco; Bernardini, Eugenio; Bernardini, Marcello; Bernardo, Benedetto; Bianchini, Giuseppe; Bisacci, Roberto; Camparini, Stefano; Chiulli, Nicola; Corda, Domenico; Crespi, Aldo; De Fiores, Antonio; Di Mitri, Roberto; Dorigo, Walter; Ebner, Juliane A; Emanuelli, Guglielmo; Ferrara, Francesco; Genovese, Giuseppe; Giacomelli, Elena; Giannasio, Benedetta; Gossetti, Bruno; Guerra, Mirko; Mattaliano, Vincenzo; Musiani, Antonello; Pieroni, Olindo; Piccioli, Riccardo; Pisacreta, Massimo; Pratesi, Carlo; Ronchey, Sonia; Quarto, Gennaro; Sellitti, Antonio; Spinelli, Giovanni M; Strati, Enzo; Tori, Antonio; Viani, Marco; Zolesio, Pierluigi

    2016-08-01

    Phlebology is not a specialty for its own in Italy. Phlebological patients are treated by vascular and general surgeons, dermatologists, phlebologists, angiologists, internists and even general practitioners. Even tough guidelines present a series of recommendations based on evidence-based medicine, guidelines may also be a tool to unify the diagnostic and therapeutic approach in a vast medical field like phlebology. Since vascular surgeons and phlebologists are particularly involved in phlebology-related pathologies the scientific societies of the Italian Society of Phlebology (SIF) and the Italian Society for Vascular and Endovascular Surgery (SICVE) decided to cooperate for the preparation of phlebo-lymphological guidelines. These guidelines comprehend also an important chapter dealing with the lymphology of the lower extremities; phlebological active physicians are often faced with lymphatic pathologies and a good differential diagnosis can be sometimes very helpful. Sclerotherapy and Surgery as the major therapeutical alternatives are extensively analyzed, but also the compression therapy, the medical and physical therapy are presented under the critical view of evidence based analyses. Separate chapters deal with the treatment alternatives for superficial and deep venous thromboses and the recommendations for the treatment of venous ulcers. The current scientific evidences were confronted with the experiences of Italian specialists and the particular practice and reality in Italy. They represent therefore the actual valid positions and recommendations in Italy which shall be updated regularly.

  10. DUSTER: collection of meteoric CaO and carbon smoke particles in the upper stratosphere .

    NASA Astrophysics Data System (ADS)

    Della Corte, V.; Rietmeijer, F. J. M.; Rotundi, A.; Ferrari, M.; Palumbo, P.

    Nanometer- to micrometer-size particles present in the upper stratosphere are a mixture of terrestrial and extra-terrestrial origins. They can be extraterrestrial particles condensed after meteor ablation. Meteoric dust in bolides is occasionally deposited into the lower stratosphere around 20 km altitude. Nanometer CaO and pure carbon smoke particles were collected at 38 km altitude in the upper stratosphere in the Arctic during June 2008 using DUSTER (Dust in the Upper Stratosphere Tracking Experiment and Retrieval), a balloon-borne instrument for the non-destructive collection of solid particles between 200 nm to 40 microns. We report the collection of micron sized CaCO_3 (calcite) grains. Their morphologies show evidence of melting and condensation after vaporization suggest at temperatures of approximately 3500 K. The formation environment of the collected grains was probably a dense dust cloud formed by the disintegration of a carbonaceous meteoroid during deceleration in the Earth� atmosphere. For the first time, DUSTER collected meteor ablation products that were presumably associated with the disintegration of a bolide crossing the Earth's atmosphere. The collected mostly CaO and pure carbon nanoparticles from the debris cloud of a fireball, included: 1) intact fragments; 2) quenched melted grains; and 3) vapor phase condensation products. The DUSTER project was funded by the Italian Space Agency (ASI), PRIN2008/MIUR (Ministero dell'Istruzione dell'Universitá e della Ricerca), PNRA 2013(Piano Nazionale Ricerca Antartide). CNES graciously provided this flight opportunity. We thank E. Zona and S. Inarta at the Laboratorio di Fisica Cosmica INAF, Osservatorio Astronomico di Capodimonte-Universitá di Napoli Parthenope. F.J.M.R. was supported by grant NNX07AI39G from the NASA Cosmochemistry Program. We thank three anonymous reviewers who assisted us in introducing our new instrument.

  11. [Nudging o educazione a scelte civiche responsabili? L'esempio dello screening della mammella].

    PubMed

    Tallacchini, Mariachiara

    2017-01-01

    "Nudge, or nudging, refers to a policy approach inspired by behavioral sciences: it promotes the conducts identified as desirable by regulators without applying prohibition and coercion. This approach has gained a lot of momentum in the domain of health policies. Policy strategies based on behavioral insights appear ideal as to implementing healthier life styles and public health programs while minimizing compliance costs: from organ donation to food choices, from fighting obesity and chronic diseases to screening policies. Nudging, however, is not exempt from problems, especially in the sector of health, where individual free and informed consent constitutes a founding principle. Cancer screening programs, and especially breast cancer population tests, represent an interesting example for nudging strategies which have been widely applied but have also raised serious criticisms. Despite having been widely adopted by health systems, from the United States to the European Union, breast cancer screening programs keep raising debates about their actual impact on reducing mortality, risks of overdiagnosing and unnecessary or harmful treatments. In challenging the validity of screening programs, these controversies also affect their efficacy. Nudging has therefore been seen as a potentially useful tool in increasing participation, even though the extent of its actual impact remains ambiguous and problematic. For nudging to represent a relevant, powerful policy instrument its legitimacy requirements need to be identified. These concern the "right place" of behavioral-based measures within the traditional regulatory framework. The "right place" of nudging in science-based policies is part of a broader rethinking of what is democracy in "knowledge-based societies", namely through which procedures democratic institutions validate and legitimize their normative choices depending on uncertain and controversial knowledge."

  12. Il Calcolo della Pasqua: Vittorio d'Aquitania Dionigi il Piccolo e Abbone di Fleury

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2014-05-01

    The Easter calculus is a story of ephemerides approximations, with appropriate algorithms, as well as the reformations of the calendar dealed with tropical year's approximations. The calculus made by Victorius of Aquitania, Dyonisius Exiguus and Abbo of Fleury, based on 532 years Easter period in Julian calendar are discussed, including the corrections ad hoc of the algorithms, like the saltus lunae.

  13. Osservare le eclisse solari dal bordo della fascia di totalità

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino; Oliva, Pietro

    2006-06-01

    Observing Solar eclipses at the totality path limits allows to measure solar diameter variations and lunar ephemerides corrections with an accuracy of a few hundredths of arcsecond. After a review of secular variations of solar diameter, presenting the eclipses of Rome 1567, London 1715, and New York City 1925, we present the current research on this topic and the phenomena occurring on the edges of the totality path. For the forthcoming eclipses, the location of observers must be chosen after calculations of limits and simulations of bead appearances and timings. We present our example in Valoria La Buena (Spain) for the 3 October, 2005 eclipse. Small unfiltered refracting telescopes, equipped with projection screen are recommended for standard observations, in order to avoid artificial reduction in the observed solar diameter due to filtering effects. Preliminary data reductions on eclipses of 1995 India and 1998 Caribbean, and on 2004 Venus Transit are also presented.

  14. Gibberellin hormone signal perception: down-regulating DELLA repressors of plant growth and development

    USDA-ARS?s Scientific Manuscript database

    The gibberellin (GA) hormone signal is perceived by a receptor with homology to hormone sensitive lipases, GID1 (GA-INSENSITIVE DWARF1). This leads to GA-stimulated responses including stem elongation, seed germination, and the transition to flowering. GA-binding enables GID1 to interact with and ...

  15. Ipotesi astronomiche sul foro della colonna augustea di Santa Maria in Aracoeli

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2014-05-01

    The third column of the left row in the Basilica of Santa Maria in Aracoeli in Rome, has a hole carved in it, of probable astronomical use. The tube aims at a point a 116 degrees of azimut, East-South-East and 17.3 degrees of altitude, the Sun could be aimed in that direction at 07:00 UTC of 12 october and 7:25 UT of march 2, but the view is obstructed by the church's building. Same situation for the 3.9 magnitude alpha Monocerotis, visible 2000 years ago, taking into account the precession. Other hypotheses on the meridian astronomical use of this hole are here reviewed. In the case of solar observations it cannot be for meridian transits in Rome, since the lower transits occurs now at 24.5 degrees at winter solstice; we investigate the case of stellar transits, of declination 30.8 degrees South. Many alignments are possible leaving the azimut as free parameter, being the columun not in its original collocation, but here we investigate only the meridian transits, and no bright stars could have been seen through that hole, taking also into account the precession 2000 years ago. We conclude that this hole was probably not used for meridian observations.

  16. Medicean telescopes. The collection of the Istituto e Museo di Storia della Scienza, Florence

    NASA Astrophysics Data System (ADS)

    Miniati, Mara

    The Institute and Museum of the History of Science in Florence preserves an important collection of 17th telescopes coming from the Medicean heritage. The paper will introduce these instruments and their connection with the contemporary astronomical and optical debate.

  17. [Power Doppler e mezzi di contrasto nello studio della membrana sinoviale reumatoide].

    PubMed

    Carotti, M; Filippucci, E; Salaffi, F

    2002-01-01

    Pannus formation is a fundamental event in the pathogenesis of rheumatoid arthritis and its hypervascularisation seems to be crucial to the development of joint damage. High-resolution greyscale ultrasonography is a safe, quick, and inexpensive imaging tool that allows an accurate detection of even minimal morphostructural changes in patients with rheumatoid arthritis, including joint effusion, thickening of synovial membrane and bone erosions. More recently, power Doppler sonography has proved to be a reliable tool for semiquantitative assessment of the vascularity of the synovial tissue. The contrast-enhanced power Doppler sonography seems to be a helpful adjunct in assessing synovitis and the therapeutic response to the different therapies in patients with rheumatoid arthritis. The aim of this radiological vignette was to show a representative example of use of power Doppler sonography with contrast agent in assessing rheumatoid synovitis.

  18. [Validazione della versione italiana del Brief Pain Inventory nei pazienti con dolore cronico].

    PubMed

    Bonezzi, C; Nava, A; Barbieri, M; Bettaglio, R; Demartini, L; Miotti, D; Paulin, L

    2002-01-01

    The purpose of this study has been the validation of an Italian version of the Brief Pain Inventory (BPI), Breve Questionario per la valutazione del Dolore (BQVD), in patients with chronic pain not-caused by neoplastic illness. The analysis has been proposed to 113 patients affected by different kinds of chronic pain of non-neoplastic origin while hospitalized, both as outpatients or as in-patients. The descriptive analysis of the specimen and of each item of the BPI has been carried out. Moreover, the psychometric characteristics of the analysis, intended as an instrument to describe intensity of pain and its interference in the various aspects of life have been investigated, evaluating with factorial analysis its validity both as a construct, and its internal coherence calculating the Cronbach's alpha of the whole instrument and of each identifier with factorial analysis. From the factorial analysis emerged a frame with three factors that have been identified as Pain intensity, Pain interference in emotional sphere and Interference in working activities. The Brief Pain Inventory can be considered a suitable useful instrument in the global evaluation of patients affected by chronic pain since its allows a contemporaneous analysis of three factors that characterize the phenomenon and contribute equally in defining the various facet of the pain universe. The Italian version of the BPI may be included in the essential evaluation instruments in the diagnosis and therapy of chronic pain.

  19. Per una pedagogia della comprensione interculturale (A Method for Teaching Intercultural Understanding).

    ERIC Educational Resources Information Center

    Titone, Renzo

    1986-01-01

    Defines true bilingualism as biculturalism, explains what "understanding" another culture means, and describes how to evaluate the effectiveness of teaching methods for students from different cultures. Ideally, individuals learning a second language will acquire a "metacultural" consciousness that permits them to be comfortable in any cultural…

  20. Singing in "La Voce Della Luna" Italian Women's Choir in Melbourne, Australia

    ERIC Educational Resources Information Center

    Southcott, Jane; Joseph, Dawn

    2015-01-01

    Australia is a country of ongoing migration that embraces diversity, creative expression and cultural activity. Membership of community music groups by older people can enhance life quality, and may provide a space through which cultural and linguistic identity may be shared and celebrated. This qualitative phenomenological case study explores…

  1. La ionosfera lunare studiata per mezzo delle occultazioni della sonda SMART-1

    NASA Astrophysics Data System (ADS)

    Pluchino, S.; Schillirã², F.; Maccone, C.; Maccaferri, G.; Derosa, C.; Firrone, C. M.

    2007-08-01

    European spacecraft SMART-1 provided an opportunity to investigate the lunar ionosphere. A set of occulations of the Moon ionosphere was obtained between August 29th and September 1st 2006. Radio occulation data in S, X and Ka-band by #2 32-meter IRA-INAF radiotelescopes were gathered. A good model of the lunar ionosphere emerged.

  2. Per una pedagogia della comprensione interculturale (A Method for Teaching Intercultural Understanding).

    ERIC Educational Resources Information Center

    Titone, Renzo

    1986-01-01

    Defines true bilingualism as biculturalism, explains what "understanding" another culture means, and describes how to evaluate the effectiveness of teaching methods for students from different cultures. Ideally, individuals learning a second language will acquire a "metacultural" consciousness that permits them to be comfortable in any cultural…

  3. L'uso della metafora nell'educazione linguistica (Use of the Metaphor in Language Instruction).

    ERIC Educational Resources Information Center

    Mininni, Giuseppe

    1986-01-01

    Urges educators to utilize metaphors in language instruction. Two experiments support this position. The results of the first experiment reveal that students learn lexical items more efficiently if presented in metaphors. The results of the second experiment indicate the usefulness of metaphors in developing students' critical thinking. (CFM)

  4. PIXE and /μ-PIXE analysis of glazes from terracotta sculptures of the della Robbia workshop

    NASA Astrophysics Data System (ADS)

    Zucchiatti, Alessandro; Bouquillon, Anne; Giancarlo Lanterna; Lucarelli, Franco; Mandò, Pier Andrea; Prati, Paolo; Salomon, Joseph; Vaccari, Maria Grazia

    2002-04-01

    A series of PIXE analyses has been performed on glazes from terracotta sculptures of the Italian Renaissance and on reference standards. The problems related to the investigation of such heterogeneous materials are discussed and the experimental uncertainties are evaluated, for each element, from the PIXE analysis of standard glasses. Some examples from artefacts coming from Italian collections are given. This research has been conducted in the framework of the COST-G1 European action.

  5. 78 FR 71022 - Culturally Significant Objects Imported for Exhibition Determinations: “Piero della Francesca...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No.......

  6. Singing in "La Voce Della Luna" Italian Women's Choir in Melbourne, Australia

    ERIC Educational Resources Information Center

    Southcott, Jane; Joseph, Dawn

    2015-01-01

    Australia is a country of ongoing migration that embraces diversity, creative expression and cultural activity. Membership of community music groups by older people can enhance life quality, and may provide a space through which cultural and linguistic identity may be shared and celebrated. This qualitative phenomenological case study explores…

  7. L'uso della metafora nell'educazione linguistica (Use of the Metaphor in Language Instruction).

    ERIC Educational Resources Information Center

    Mininni, Giuseppe

    1986-01-01

    Urges educators to utilize metaphors in language instruction. Two experiments support this position. The results of the first experiment reveal that students learn lexical items more efficiently if presented in metaphors. The results of the second experiment indicate the usefulness of metaphors in developing students' critical thinking. (CFM)

  8. I termini di Cassini e Laplace della rifrazione atmosferica misurati alla Meridiana Clementina

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2016-05-01

    The measures of the atmospheric refraction terms of Cassini and Laplace are made at the Clementine Meridian Line of S. Maria degli Angeli in Rome by comparing the observed positions of the center of the Sun with the ones calculated without atmosphere. Three linear systems with the data of 21 Dec 2015; 18 Jan and 6 Feb 2016 give the refraction terms of tan(z) and tan3(z).

  9. [Levels of trace elements in the fruits and vegetables from the so-called Land of fires in Campania Region (Southern Italy)].

    PubMed

    Esposito, Mauro; Cavallo, Stefania; Rosato, Guido; Chiaravalle, Eugenio; Miedico, Oto; Pellicanò, Roberta; Soprano, Vittorio; Baldi, Loredana

    2016-01-01

    INTRODUZIONE: una vasta area compresa tra le province di Napoli e Caserta nella regione Campania ha negli ultimi anni attirato l'attenzione dei mass media a causa degli interramenti illeciti di rifiuti di varia origine nei campi o del loro abbandono lungo le strade. A tali pratiche illecite si aggiunge il fenomeno dei roghi incontrollati di questo materiale, motivo per il quale la zona è stata soprannominata "Terra dei fuochi". OBIETTIVI: ricerca di elementi in tracce presenti nei prodotti alimentari di origine vegetale prodotti nella Terra dei fuochi. DISEGNO E SETTING: piano di monitoraggio per il rilevamento dei livelli di alcuni metalli tossici ed essenziali nei vegetali coltivati in Campania nella Terra dei fuochi. La determinazione dei microelementi è stata effettuata dopo mineralizzazione della sostanza organica mediante microonde, utilizzando la spettrometria di massa a plasma induttivamente accoppiato (ICP-MS). RISULTATI: durante l'attività di monitoraggio sono stati raccolti 65 campioni di ortaggi e 49 campioni di frutta in 43 comuni rientranti nella Terra dei fuochi. Il contenuto medio di metalli tossici, cadmio e piombo nei prodotti ortofrutticoli è risultato ben lontano dai limiti massimi fissati dalla normativa europea. I valori delle concentrazioni sono significativamente inferiori rispetto a quanto riscontrato in zone ad alto impatto ambientale a causa della presenza di impianti industriali. CONCLUSIONI: la presenza di elementi tossici o potenzialmente tali nei campioni vegetali prodotti nella Terra dei fuochi è attribuibile a una varietà di fattori ambientali rilevanti (caratteristiche geologiche dell'area, inquinamento del suolo, dell'atmosfera e delle acque di irrigazione, pratiche illecite di smaltimento dei rifiuti industriali); non sembra, tuttavia, sussistere un rischio per la salute dei consumatori. Resta comunque l'allerta per la loro presenza nell'ambiente e la necessità che le attività di monitoraggio continuino.

  10. The EEE Project

    NASA Astrophysics Data System (ADS)

    Abbrescia, M.; An, S.; Antolini, R.; Badala, A.; Baldini Ferroli, R.; Bencivenni, G.; Blanco, F.; Bressan, E.; Chiavassa, A.; Chiri, C.; Cifarelli, L.; Cindolo, F.; Coccia, E.; de Pasquale, S.; di Giovanni, A.; d'Incecco, M.; Fabbri, F.L.; Frolov, V.; Garbini, M.; Gustavino, C.; Hatzifotiadou, D.; Imponente, G.; Kim, J.; La Rocca, P.; Librizzi, F.; Maggiora, A.; Menghetti, H.; Miozzi, S.; Moro, R.; Panareo, M.; Pappalardo, G.S.; Piragino, G.; Riggi, F.; Romano, F.; Sartorelli, G.; Sbarra, C.; Selvi, M.; Serci, S.; WIlliams, C.; Zichichi, A.; Zuyenski, R.

    The EEE (/Extreme Energy Event/) Project is an experiment for the study of very high-energy extensive air showers, actually starting in Italy. It is based on the detection of the shower muon component by means of a network of tracking detectors, installed in Italian High Schools. The Project, supported by the Ministero dell’Università e della Ricerca (MIUR), Istituto Nazionale di Fisica Nucleare (INFN), European Organization for Nuclear Research (CERN) and Museo Storico della Fisica e Centro Studi e Ricerche “E. Fermi” has been conceived by its leader Professor Antonino Zichichi. In its first phase the detector telescopes will be installed in 21 High Schools in 7 piloting cities all over Italy. The network will soon be heavily upgraded by increasing the number of High Schools and cities. The single tracking telescope is composed by 3 large (~ 2 m2 ) Multi-gap Resistive Plate Chambers (MRPC), realized with float glass electrodes. The use of particle detectors based on such MRPCs will allow to determine with a very high accuracy the direction of the axis of cosmic ray showers initiated by primaries of ultra-high energy, together with a high temporal resolution. The first MRPC telescope, installed in the Liceo Scientifico “B.Touschek” in Grottaferrata near the LNF-INFN site (nearby Rome), is successfully running. By the end of year 2007, the installation of the other telescopes will open the way for the first search of high-energy cosmic rays distant coincidences. In the future, serving many High Schools scattered all over the Italian territory, the EEE Project will also allow to investigate coincidences between multiple primaries producing distant showers. Here we present the experimental apparatus and its tasks.

  11. The MAGIC-5 CAD for nodule detection in low dose and thin slice lung CTs

    NASA Astrophysics Data System (ADS)

    Cerello, Piergiorgio; MAGIC-5 Collaboration

    2010-11-01

    Lung cancer is the leading cause of cancer-related mortality in developed countries. Only 10-15% of all men and women diagnosed with lung cancer live 5 years after the diagnosis. However, the 5-year survival rate for patients diagnosed in the early asymptomatic stage of the disease can reach 70%. Early-stage lung cancers can be diagnosed by detecting non-calcified small pulmonary nodules with computed tomography (CT). Computer-aided detection (CAD) could support radiologists in the analysis of the large amount of noisy images generated in screening programs, where low-dose and thin-slice settings are used. The MAGIC-5 project, funded by the Istituto Nazionale di Fisica Nucleare (INFN, Italy) and Ministero dell'Università e della Ricerca (MUR, Italy), developed a multi-method approach based on three CAD algorithms to be used in parallel with a merging of their results: the Channeler Ant Model (CAM), based on Virtual Ant Colonies, the Dot-Enhancement/Pleura Surface Normals/VBNA (DE-PSN-VBNA), and the Region Growing Volume Plateau (RGVP). Preliminary results show quite good performances, to be improved with the refining of the single algorithm and the added value of the results merging.

  12. Una Ricerca sull'Applicazione del TALB (Test di Attitudine Linguistica per Bambini) nella Scola Elementare [Research on the Application of the TALB (A Test for Linguistic Aptitude for Children) in Elementary School].

    ERIC Educational Resources Information Center

    Acone, Ilario

    1992-01-01

    Discusses the administration of the Test di Attitudine Linguistica per Bambini (TALB) to students 7-9 years of age. Correlations between the TALB and achievement tests administered at the end of the course were very high. It is concluded that aptitude is a main factor in successful learning of a second language. (16 references) (LET)

  13. Anti-Ro/SSA-p200 antibodies in the prediction of congenital heart block. An Italian multicentre cross-sectional study on behalf of the 'Forum Interdisciplinare per la Ricerca nelle Malattie Autoimmuni (FIRMA) Group'.

    PubMed

    Scarsi, Mirko; Radice, Antonella; Pregnolato, Francesca; Ramoni, Veronique; Grava, Chiara; Bianchi, Laura; Gerosa, Maria; Mosca, Marta; Ghirardello, Anna; Tani, Chiara; Motta, Mario; Quinzanini, Marzia; Tincani, Angela; Ruffatti, Amelia; Migliorini, Paola; Doria, Andrea; Meroni, Pier Luigi; Brucato, Antonio

    2014-01-01

    To verify the association between the presence of specific anti-52 Ro/SSA-p200 antibodies and congenital heart block (CHB). 207 pregnant Italian women carrying anti-Ro/SSA Ab were retrospectively evaluated. Anti-p200 Ab were investigated in the mothers' sera by ELISA (Euro-Diagnostica,Wieslab SS-A p200). CHB occurred in 42 children (34 complete CHB), whereas 165 were not affected. All CHB cases were previously identified with an ELISA screening for anti-Ro/SSA 60 kD Ab. Anti-p200 Ab were more frequently positive (81.0% vs. 59.1%, p=0.013) and at a higher titer in CHB mothers (Absorbance ratio: 2.030 (0.208-4.052) vs. 0.925 (0.200-3.816); p=0.017). This association was maintained even when the 42 mothers of children with CHB were compared with a control group matched for age and diagnosis (80.9% vs. 50.0%; p=0.006). The presence of anti-p200 Ab provided an odds ratio (OR) for CHB of 2.98 (CI: 1.30-6.83), which was higher than that of other variables, such as maternal disease and other antibody specificities. CHB risk significantly decreased in the absence of this fine specificity (OR:0.34, CI: 0.15-0.77). However, while the negative predictive value related to anti-Ro/SSA 60 kD Ab ELISA was 100%, almost 20% of mothers negative for anti-p200 Ab delivered babies with CHB. Anti-p200 antibodies seem to be associated with CHB with a higher probability than anti-Ro/SSA Ab, and therefore may be an additional test to identify mothers at higher risk to deliver affected children. An ELISA screening for anti-Ro/SSA 60 kD Ab is nevertheless mandatory given the probability of developing CHB also in the absence of anti-p200 Ab.

  14. Una Ricerca sull'Applicazione del TALB (Test di Attitudine Linguistica per Bambini) nella Scola Elementare [Research on the Application of the TALB (A Test for Linguistic Aptitude for Children) in Elementary School].

    ERIC Educational Resources Information Center

    Acone, Ilario

    1992-01-01

    Discusses the administration of the Test di Attitudine Linguistica per Bambini (TALB) to students 7-9 years of age. Correlations between the TALB and achievement tests administered at the end of the course were very high. It is concluded that aptitude is a main factor in successful learning of a second language. (16 references) (LET)

  15. Attivita del Centro di Linguistica Applicata nel campo della lingua e della cultura italiana all'estero (Activities of the Italian Center for Applied Linguistics concerning Italian Language and Culture Abroad).

    ERIC Educational Resources Information Center

    Boriosi Katerinov, Maria Clotilde

    1979-01-01

    Outlines the activities of a recently created section of the Italian Center for Applied Linguistics (CILA), dealing with "Teaching Italian Abroad." Describes these activities as encompassing four areas: research, teaching methodology, consultation, teachers' training and bibliographical information. Lists statistical surveys, research papers, and…

  16. Comparative Evaluation of ERASMUS ICPs in the Subject Areas of Business Management, Chemistry and History. ERAMUS Monographs No 8 = Valutazione Comparata dei pic ERASMUS nelle Aree Disciplinari dell'Organizzazione Aziendale, della Chimica e della Storia. Monografie ERASMUS No. 8.

    ERIC Educational Resources Information Center

    Monasta, Attilio

    This report presents results from one of several research studies involving the European Community Action Scheme for the Mobility of University Students (ERASMUS), one of the inter-university cooperation programs initiated by the Commission of European Communities. It is noted that ERASMUS, as well as the other inter-university cooperation…

  17. Attivita del Centro di Linguistica Applicata nel campo della lingua e della cultura italiana all'estero (Activities of the Italian Center for Applied Linguistics concerning Italian Language and Culture Abroad).

    ERIC Educational Resources Information Center

    Boriosi Katerinov, Maria Clotilde

    1979-01-01

    Outlines the activities of a recently created section of the Italian Center for Applied Linguistics (CILA), dealing with "Teaching Italian Abroad." Describes these activities as encompassing four areas: research, teaching methodology, consultation, teachers' training and bibliographical information. Lists statistical surveys, research papers, and…

  18. Azimut e altezza della Piramide Cestia in una sola osservazione del Sole e dell'ombra proiettata

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2016-07-01

    The astronomical azimut and heigth of the Cestia Pyramid in Rome have been measured as 205° and 36 m by observing the alignment of the Sun with the axis and the grazing shadow of the Pyramid on July 22nd.

  19. Radio Map of the Milky Way at 1420 Mhz. (Italian Title: Mappa Radio della Via Lattea a 1420 MHz)

    NASA Astrophysics Data System (ADS)

    Sandri, M.; Bettelli, E.; Grandi, E.; Fedrizzi, R.; Fellin, R.; Larcher, M.; Ziller, M.

    2013-08-01

    The purpose of this work is to obtain the curve of rotation of the Milky Way, to map the spiral structure of the Galaxy and to determine its integral mass. This is done through the study of the galactic neutral hydrogen concentration. We used the radio telescope Salsa Onsala Vale',a 2.3 m diameter parabolic dish, built by the Onsala Space Observatory at the Chalmers University of Technology in Sweden. Theutilized data are referred to several observations performed between December 22nd 2011 and January 6th 2012. For the data processing, the software SalsaJ was used. The result of this study confirms that the rotation velocity of the Galaxy, far away from the galactic center, does not decrease, but remains almost the same. The distribution of the neutral hydrogen is not uniform: it is concentrated in filamentary structures which are considered an evidence of the Milky Way spiral structure.

  20. L'Astronomia del Venerdí Santo, l'eclissi di Luna e l'ora della Sindone

    NASA Astrophysics Data System (ADS)

    Sigismondi, Costantino

    2014-05-01

    Dating the crucifixion on friday 3 April 33, when, at sunset a partially eclipsed Moon rised allows to interprete the speech of Saint Peter (Acts 2:20=Joel 3:4) on the day of Pentecost as including an account of this eclipse, as fulfillment of the Scriptures. Few minutes later the apparition of a third star of medium magnitude stated the beginning of the sabbatical rest: before that time Jesus has been buried, wrapped into the shroud. The observations of the equinoctial moonrise from the Mount of Olives on September 2013 are strongly in favour of the hypotehsis of possible observation of the lunar eclipse of 33 AD by Jewish people, as well as the sunrises observed from the Temple Institute terrace in Southern-East Jerusalem demonstrated that this eclipse could have been seen from Jerusalem. The depression of the horizon and the refraction allow to see Sun and Moon more than 1 degree below the geometrical horizon in the azimuthal direction ranging from 90 to 116, prologing to 16 minutes the duration of the partial lunar eclipse observed in 33AD. Texts of Matthew, Mark and Cyrillus of Jerusalem are also commented.

  1. Catholicism, Fascism and Italian Education from the Riforma Gentile to the Carta Della Scuola, 1922-1939.

    ERIC Educational Resources Information Center

    Wolff, Richard J.

    1980-01-01

    Examines church-state relations in educational matters in Italy from 1922 to the outbreak of World War II. Unlike Nazi Germany which could boast of nazified schools, Fascist Italy was compelled to recognize the considerable influence of Catholicism on education. (Author/KC)

  2. Prime linee-guida per l'uso della webcam bidirezionale con bambini affetti da patologia oncologica in fase avanzata.

    PubMed

    Giacon, B; Biassoni, V; Clerici, C A; Spreafico, F; Meazza, C; Veneroni, L; Massimino, M

    2014-07-14

    AIM:The paper presents guidelines for school staff on the use of two-way webcam for the sake of school-continuity with school children suffering from malignant tumors. The proposed guidelines are designed to prepare school staff about the interests of those involved in the interaction (sick child,classmates, teachers).

  3. [The ECCIS study: the epidemiology and clinical picture of silent ischemic cardiopathy. Epidemiologia e Clinica della Cardiopatia Ischemica Silente].

    PubMed

    Fazzini, P F; Prati, P L; Rovelli, F; Antoniucci, D; Menghini, F; Seccareccia, F; Menotti, A

    1994-12-01

    The ECCIS project (Epidemiology and Clinic of Silent Ischemic Heart Disease) is an italian epidemiological study based on a population sample of 4,842 totally asymptomatic men aged 40-59 whose primary aim is the evaluation of the prevalence of totally silent myocardial ischemia and silent myocardial infarction. The systemic search for markers of silent ischemia and infarction was pursued along 3 screening stages: the 1st stage included resting electrocardiogram, hyperventilation test, exercise electrocardiogram and 24-hour Holter electrocardiogram; the 2nd stage included echocardiogram, thallium-201 scintigraphy in conjunction with exercise test or dypiridamole test, exercise radionuclide ventriculography and ergometrine test; the 3rd stage included coronary angiography. After the completion of the 1st stage procedures 439 men (9.1%) with abnormal results and low probability of disease were invited to the 2nd stage and 387 accepted to undergo the diagnostic procedures. After the completion of the 2nd stage, 104 men with moderate or high suspicion of silent myocardial ischemia or infarction were invited to perform coronary angiography but only 62 men accepted to undergo the 3rd stage procedures (participation rate 59.6%). The final diagnosis of totally silent myocardial ischemia or infarction on the basis of predefined criteria was established in 25 patients. The prevalence of silent ischemic heart disease on the overall original 4,842 men was 0.52% (95% CL, 0.32 and 0.72%), while the final estimate after adjusting for participation rates at 2nd and 3rd stages was 0.89% (95% CL, 0.6 and 1.1%). The results of the ECCIS study show that the prevalence of silent myocardial ischemia is definitely lower than that revealed by prior epidemiological studies in Norway and in USA.

  4. [Estensione dell'età-bersaglio del programma di screening mammografico e governo della pratica mammografica in Emilia-Romagna].

    PubMed

    Sassoli de Bianchi, Priscilla; Ravaioli, Alessandra; Ferretti, Stefano; Finarelli, Alba Carola; Giannini, Adriana; Naldoni, Carlo; Sanna, Piera; Bucchi, Lauro

    2017-01-01

    "OBJECTIVES: to evaluate the effectiveness of the regional law No.1035 enacted in 2009 by the local government of the Emilia- Romagna Region (Northern Italy) with the purpose of revising the rules of access to breast-care services. The law dictated the extension of the organised mammography screening programme to women aged 45-49 and 70-74 years in order to decrease their spontaneous screening rates and, thus, the waiting times for the access to diagnostic mammography by women of all ages. study of time trends (joinpoint regression analysis and before/ after analysis) in annual percent mammography rates and in waiting times for access to clinical radiology facilities (2006-2014) among resident women. The information was taken from the regional Department of Health. public and accredited private radiology facilities. age-specific and waiting-time-specific (months) percent rates of organised screening mammography, spontaneous screening mammography, and diagnostic mammography. following the regional law No.1035, screening rates among women aged 45-49 and 70-74 years reached levels comparable to those attained by women aged 50-69 years. Spontaneous screening rates dropped and waiting times for spontaneous screening mammography (women aged 40-44 years) were cut. For diagnostic mammography, the rates remained stable, except for a decrease among women aged 35-39 and 45-49 years, and waiting times decreased in a constant manner over the study period. the above-mentioned law met most of its goals. Comprehensive programmes regulating mammography practice at the population level can be effective."

  5. L'influenza dell'attenzione, della memoria e della discriminazione fonetica nell'apprendimento della seconda lingua nella scuola elementare: Risultati di alcuni test (Influence of Attention, Memory, and Phonetic Discrimination in Second Language Learning in Elementary School: Results of Several Tests).

    ERIC Educational Resources Information Center

    Colonna-Preti, Paola; Taeschner, Traute

    1987-01-01

    Using a new method, 48 children in an elementary school in Rome, Italy, were taught a foreign language (26 English, 22 German) and tested after three years. The authors attempt to explain the variation in test results in terms of the students' attention, memory, and phonetic discrimination. (CFM)

  6. L'influenza dell'attenzione, della memoria e della discriminazione fonetica nell'apprendimento della seconda lingua nella scuola elementare: Risultati di alcuni test (Influence of Attention, Memory, and Phonetic Discrimination in Second Language Learning in Elementary School: Results of Several Tests).

    ERIC Educational Resources Information Center

    Colonna-Preti, Paola; Taeschner, Traute

    1987-01-01

    Using a new method, 48 children in an elementary school in Rome, Italy, were taught a foreign language (26 English, 22 German) and tested after three years. The authors attempt to explain the variation in test results in terms of the students' attention, memory, and phonetic discrimination. (CFM)

  7. PREFACE: Young Researcher Meeting, Trieste 2013

    NASA Astrophysics Data System (ADS)

    Agostini, F.; Antolini, C.; Aversa, R.; Cattani, G.; Martinelli, M.; Mazzaferro, L.; Migliaccio, M.; Paci, F.; Pietrobon, D.; Ricci Pacifici, D.; Stellato, F.; Veneziani, M.

    2013-12-01

    YRM logo The Young Researcher Meeting (www.yrmr.it) has been a rapidly growing event for the last few years. Together with other initiatives which have emerged in several research areas, the young researcher meeting marks the awareness and the desire of PhD students, postdoctoral fellows and young researchers to play a major role in scientific progress. Devoted to the discussion and the interchange of new developments and ideas in physics, the meeting is primarily aimed at graduate students and postdoctoral researchers, who are encouraged to present their work in an informal atmosphere. One of the main purposes of the conference is to create an international network of young researchers, both experimentalists and theorists, and fruitful collaborations across the different branches of physics. Born in Rome in 2009, after three editions that strengthened it, the Young Researcher Meeting 2013 was held in Trieste. Propelled by the past success, the fourth meeting was a two-day conference on 3-4June. It was sponsored by the International School for Advanced Studies - SISSA - and the University of Padova, thus acquiring an even further international drive. In this volume, we collect some of the contributions that were presented at the conference. They cover topics in astrophysics and cosmology, particle and theoretical physics, soft and condensed matter, biophysics and medical physics. YRM Organising and Editorial Committee Fabio Agostini (fabio.agostini@roma2.infn.it) Dipartimento di Fisica, Università di Roma 'Tor Vergata' Via della Ricerca Scientifica 1, 00133 Roma, Italy Claudia Antolini (claudia.antolini@sissa.it) SISSA - Scuola Internazionale Superiore di Studi Avanzati Via Bonomea 265, 34136 Trieste, Italy Rossella Aversa (raversa@sissa.it) SISSA - Scuola Internazionale Superiore di Studi Avanzati Via Bonomea 265, 34136 Trieste, Italy Giordano Cattani (giordano.cattani@gmail.com) Matteo Martinelli (mmartin@sissa.it) SISSA - Scuola Internazionale Superiore di

  8. Eyelid dermatitis: an evaluation of 447 patients.

    PubMed

    Ayala, Fabio; Fabbrocini, Gabriella; Bacchilega, Roberto; Berardesca, Enzo; Caraffini, Stefano; Corazza, Monica; Flori, Maria Laura; Francalanci, Stefano; Guarrera, Marcella; Lisi, Paolo; Santucci, Baldassarre; Schena, Donatella; Suppa, Francesco; Valsecchi, Rossano; Vincenzi, Colombina; Balato, Nicola

    2003-06-01

    Eyelids can be affected by various types of dermatitis that are often difficult to diagnose. The aim of the study was to establish some guidelines for a correct diagnosis. A total of 447 patients treated at 12 research units for eczema or other inflammatory dermatitis located on the eyelids were invited to complete a questionnaire. When necessary, patch tests with haptens of the standard series from Gruppo Italiano di Ricerca sulle Dermatiti da Contatto e Ambientali della Società Italiana di Dermatologia e Venereologia (SIDEV-GIRDCA) were performed. Of the subjects studied, 50.2 % were diagnosed with allergic contact dermatitis (ACD); 20.9% were affected by irritant contact dermatitis (ICD), 13.5% by atopic dermatitis, 6.3% by seborrheic dermatitis, 6.5% by aspecific xerotic dermatitis, and 2.3% by psoriasis. Approximately 91% of all subjects reported an absence of familial atopy. A significant statistical association between diagnosis type and a personal history of atopy was evident (p <.000001, chi-square test). The results of gradual logistic regression models showed four-eyelid involvement as the main risk factor for ACD (odds ratio [OR] = 3.0; 95% CI, 1.1-8.1); with ICD, the main risk factor was the onset of symptoms at between 2 and 6 months (OR = 2.1; 95% CI, 1.1-4.0), whereas for atopic dermatitis, the main risk factors were the onset of symptoms later than 6 months and a personal history of atopy (OR = 4.9 and 3.6, respectively). Results suggest that many characteristics of the patients examined can be used for the differential diagnosis of palpebral eczematous dermatitis.

  9. Integrated approach of nutritional and molecular epidemiology, mineralogical and chemical pollutant characterisation: the protocol of a cross-sectional study in women

    PubMed Central

    Barchitta, Martina; Quattrocchi, Annalisa; Maugeri, Andrea; Barone, Germana; Mazzoleni, Paolo; Catalfo, Alfio; De Guidi, Guido; Iemmolo, Maria; Crimi, Nunzio; Agodi, Antonella

    2017-01-01

    Introduction Environmentally-related health and disease are the result of the exposome, the totality of a person's environmental exposures, from all sources and routes, across their lifespan. Epigenetic phenomena, including DNA methylation, can be potentially modified by environmental and lifestyle factors, and result in environmental reprogramming of the genome for exposed individuals and for future generations of offspring. Objective The objective of the project is to evaluate the risk of DNA hypomethylation due to air pollution, Mediterranean diet adherence, folate intake, and demographic and socioeconomic factors, in healthy women living in the metropolitan area of Catania, Italy. Methods and analysis Non-pregnant healthy women will be enrolled in a cross-sectional study. Sociodemographic, lifestyle and dietary intake information will be collected. LINE-1 methylation will be measured by pyrosequencing. The participants' home addresses will be geocoded and each woman will be assigned to the closest monitoring station for particulate matter (PM) exposure assessment. Mineralogical-chemical characterisation of PM and cellular model assays will be performed. An integrated approach will be designed to estimate the combined possible effect of air pollution, Mediterranean diet adherence, folate intake and other lifestyle characteristics on LINE-1 methylation levels. Ethics and dissemination The project has been approved by the ethics committees of the involved institution and funded by the University of Catania (Finanziamento della Ricerca, FIR 2014). All participants will be fully informed of the purpose and procedures of the study, and signed written consents will be obtained. All the data collected will be treated confidentially and analysed in an aggregate and anonymous way. The results will be published in peer-reviewed journals and communicated to local public health agencies, in order to provide essential information for timely and effective public health action

  10. Integrated approach of nutritional and molecular epidemiology, mineralogical and chemical pollutant characterisation: the protocol of a cross-sectional study in women.

    PubMed

    Barchitta, Martina; Quattrocchi, Annalisa; Maugeri, Andrea; Barone, Germana; Mazzoleni, Paolo; Catalfo, Alfio; De Guidi, Guido; Iemmolo, Maria; Crimi, Nunzio; Agodi, Antonella

    2017-04-04

    Environmentally-related health and disease are the result of the exposome, the totality of a person's environmental exposures, from all sources and routes, across their lifespan. Epigenetic phenomena, including DNA methylation, can be potentially modified by environmental and lifestyle factors, and result in environmental reprogramming of the genome for exposed individuals and for future generations of offspring. The objective of the project is to evaluate the risk of DNA hypomethylation due to air pollution, Mediterranean diet adherence, folate intake, and demographic and socioeconomic factors, in healthy women living in the metropolitan area of Catania, Italy. Non-pregnant healthy women will be enrolled in a cross-sectional study. Sociodemographic, lifestyle and dietary intake information will be collected. LINE-1 methylation will be measured by pyrosequencing. The participants' home addresses will be geocoded and each woman will be assigned to the closest monitoring station for particulate matter (PM) exposure assessment. Mineralogical-chemical characterisation of PM and cellular model assays will be performed. An integrated approach will be designed to estimate the combined possible effect of air pollution, Mediterranean diet adherence, folate intake and other lifestyle characteristics on LINE-1 methylation levels. The project has been approved by the ethics committees of the involved institution and funded by the University of Catania (Finanziamento della Ricerca, FIR 2014). All participants will be fully informed of the purpose and procedures of the study, and signed written consents will be obtained. All the data collected will be treated confidentially and analysed in an aggregate and anonymous way. The results will be published in peer-reviewed journals and communicated to local public health agencies, in order to provide essential information for timely and effective public health action. Published by the BMJ Publishing Group Limited. For permission to

  11. 78 FR 52601 - Culturally Significant Object Imported for Exhibition; Determinations: “Visiting Masterpiece...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... Francesca's Senigallia Madonna, an Italian Treasure, Stolen and Recovered'' and ``Piero della Francesca...: Piero della Francesca's Senigallia Madonna, An Italian Treasure, Stolen and Recovered'' at the Museum of...

  12. Rapporto tra sviluppo cognitivo e competenza sintattica: Ricerca sul rapporto tra variabili cognitive e complessita sintattica in bambini di scuola elementare (Relationship between Cognitive Development and Syntactic Competence: Research on the Relationship between Cognitive Variables and Syntactic Complexity in Elementary School Children).

    ERIC Educational Resources Information Center

    Bellachi, C.; Benelli, B.

    1988-01-01

    Explains the relationship between understanding a temporal or causal event and the ability to articulate and comprehend sentences about the event. The subjects of the research were 60 children from an Italian elementary school, 20 each from the first, third, and fifth grades. (CFM)

  13. [The consultation with the candidate couple for intracytoplasmic sperm injection (ICSI) using microsurgical epididymal sperm aspiration (MESA) or testicular sperm aspiration (TESA). The experience of the MATRIS (Medici Associati per la Terapia e la Ricerca dell'Infertilità e Sterilità) center of Milan].

    PubMed

    Magro, B; Magro, S

    1998-04-01

    The authors examine the relationship between doctor and patient during the consultation for the therapeutic decision for those couples who have to undergo a medical procreation, especially the ICSI by MESA and TESA. The couple's psycho-emotional involvement and the medical terminology hinder the real possibility of communication between doctor and patient. The data relating to a study of 80 couples done by the authors are presented. They show the need to improve the quality of communication between doctor and patient during the consultation. For this purpose, on the basis of the research conducted, modification of the language used and the support of audio-visual media are suggested during the consultation in order to reduce the percentage of the couple's doubts and uncertainties.

  14. Development of decision support system for oil spill management in the Mediterranean Sea

    NASA Astrophysics Data System (ADS)

    Liubartseva, Svitlana; Coppini, Giovanni; Pinardi, Nadia; De Dominicis, Michela; Marra, Palmalisa; Lecci, Rita; Turrisi, Giuseppe; Creti, Sergio; Martinelli, Sara; Agostini, Paola; Palermo, Francesco

    2016-04-01

    developed as a part of TESSA Project portfolio providing the unified access to others services. Thus, SEACONDITIONS (http://www.sea-conditions.com) performs visualization and on-line delivery of forecast of surface currents, sea surface temperature, significant wave height and direction, wave period and direction; air temperature, surface pressure, precipitation, cloud coverage, wind speed, etc. Apart from the basin scale visualization SEACONDITIONS supports the zooming capability. User feedback reports from fishermen, port authorities including Coast Guard, offshore companies, aquatic and coastal tourism managers, and academia have been collected and used for the system improvements. User-friendliness of GUI, tooltips, an opportunity to vary the advanced parameters, efficiency of the visualization tool, and a help section were appreciated in these reports. In accordance with the users' requirements, a to-do list is composed for the further development of WITOIL. This work was performed in the framework of the TESSA Project (Sviluppo di TEcnologie per la Situational Sea Awareness) supported by PON (Ricerca & Competitività 2007-2013) cofunded by UE (Fondo Europeo di sviluppo regionale), MIUR (Ministero Italiano dell'Università e della Ricerca), and MSE (Ministero dello Sviluppo Economico). References De Dominicis, M., Pinardi, N., Zodiatis, G., and Lardner, R., 2013. MEDSLIK-II, a Lagrangian marine surface oil spill model for short term forecasting - Part 1: Theory. Geosci. Model Dev. 6, 1851-1869.

  15. Mutual Phenomena between Galilean Satellites: PHEMU09 Campaign in Italy. (Italian Title: Occultazioni ed eclissi tra i satelliti medicei: i risultati della campagna PHEMU09 in Italia)

    NASA Astrophysics Data System (ADS)

    Marino, G.; Arena, C.; Barbieri, L.; Lopresti, C.; Lo Savio, E.; Marchini, A.; Masi, G.; Maulella, R.; Napoli, C.; Salvaggio, F.; Sbarufatti, G.; Sciuto, C.; Ruocco, N.; Ruisi, R.; Sofia, A.; Tontodonati, E.; Zambelli, R.

    2011-06-01

    Results of photometry of mutual phenomena between Galilean satellites are presented. The observations were performed in Italy during the international campaign PHEMU09.Relevant deviations (O-C) with respect to the expected central instants are present for many events. Taking into account the relative satellites’ longitudinal velocity, longitudinal discrepancies in km (and arcsec) are also computed. The discrepancies with respect to the expected flux drops during the occultations are apparently uncorrelated with the O-C on timing (and longitudinal deviations in km); moreover, for eclipses they seem greater than for occultations

  16. [La percezione del rapporto ambiente-salute secondo i dati della sorveglianza Progressi delle aziende sanitarie per la salute in Italia (PASSI)].

    PubMed

    Sampaolo, Letizia; Tommaso, Giulia; Gherardi, Bianca; Carrozzi, Giuliano; Freni Sterrantino, Anna; Ottone, Marta; Goldoni, Carlo Alberto; Bertozzi, Nicoletta; Scaringi, Meri; Bolognesi, Lara; Masocco, Maria; Salmaso, Stefania; Lauriola, Paolo

    2017-01-01

    "OBJECTIVES: to identify groups of people in relation to the perception of environmental risk and to assess the main characteristics using data collected in the environmental module of the surveillance network Italian Behavioral Risk Factor Surveillance System (PASSI). perceptive profiles were identified using a latent class analysis; later they were included as outcome in multinomial logistic regression models to assess the association between environmental risk perception and demographic, health, socio-economic and behavioural variables. the latent class analysis allowed to split the sample in "worried", "indifferent", and "positive" people. The multinomial logistic regression model showed that the "worried" profile typically includes people of Italian nationality, living in highly urbanized areas, with a high level of education, and with economic difficulties; they pay special attention to their own health and fitness, but they have a negative perception of their own psychophysical state. the application of advanced statistical analysis enable to appraise PASSI data in order to characterize the perception of environmental risk, making the planning of interventions related to risk communication possible. ".

  17. Problemi dell'Insegnamento della Lingua Russa Come Lingua Straniera ai Filologi Russisti (Problems of Teaching Russian as a Foreign Language to Philologists of Russian)

    ERIC Educational Resources Information Center

    Gak, V. G.

    1977-01-01

    Frequently, universities prepare philologists of Russian for future careers as researchers, when most of them will become teachers of Russian as a foreign language. This article suggests a course of studies more suitable for future teachers. (Text is in Italian.) (CFM)

  18. Curriculum Guide for Italian Language Arts. Literature Levels AB = Guida alla Lettura della Lingua Italiana Letteratura Ciclo A & B. Working Draft.

    ERIC Educational Resources Information Center

    Chicago Board of Education, IL. Dept. of Curriculum.

    A curriculum and teaching guide for introductory literature appreciation in the Chicago public schools is an orientation for the bilingual teacher of Italian students. Concepts such as rhyme and personification are developed for the teacher. For each of the two levels included, the section begins with a list of specific performance objectives,…

  19. L'insegnamento della lingua inglese nella scuola materna: un'indagine in area romana (Teaching English in Preschool: A Survey in the Rome Area).

    ERIC Educational Resources Information Center

    Brevetti, Franca

    1987-01-01

    Presents the results of a survey to determine the extent to which English was taught and what methods were used in public and private nursery schools in Rome, Italy, during the academic year 1985-86. (CFM)

  20. Insegnamento della lingua seconda (italiano) nella scuola primaria: l'esperienza altoatesina (Teaching Italian as a Second Language in Elementary School: The Upper Adige Experience).

    ERIC Educational Resources Information Center

    Bertocchi, Daniela

    1979-01-01

    Provides an evaluation of a 30-year experience in teaching Italian to German-speaking elementary school children in an upper northeast region of Italy. Analyzes degrees of bilingualism and sociocultural contact, emphasizing the need for culturally oriented, carefully structured materials and instruction by specially trained teachers. (MES)

  1. Sintassi e tassonomia: Teoria della valenza e lessico-grammatica in tedesco e in italiano (Syntax and Taxonomy: Theory of Valence and Lexical Grammar in German and Italian).

    ERIC Educational Resources Information Center

    Bianco, Maria Teresa

    1986-01-01

    Briefly discusses the concepts of "subject,""complement,""transitivity," and "intransitivity," contrasts the classes of complements in German and Italian based on identical criteria of classification, justifies such a classification for complements, and suggests didactic implications for the theory of…

  2. Office and 24-h ambulatory blood pressure control by treatment in general practice: the 'Monitoraggio della pressione ARteriosa nella medicina TErritoriale' study.

    PubMed

    Zaninelli, Augusto; Parati, Gianfranco; Cricelli, Claudio; Bignamini, Angelo A; Modesti, Pietro A; Pamparana, Franco; Bilo, Grzegorz; Mancia, Giuseppe; Gensini, Gian F

    2010-05-01

    Guidelines recommend that blood pressure (BP) should be lowered in hypertensive patients to prevent cardiovascular accidents. Management of antihypertensive treatment by general practitioners is usually based on office measurements, which may not allow an assessment of BP control over 24 h, which requires ambulatory BP monitoring (ABPM) to be implemented. This is rarely done in general practice, and limited information is available on the consistency between the evaluations of the response to treatment provided by office measurement and by ABPM in this setting. To assess concordance between office BP measurements and ABPM-based estimates of hypertension control in a general practice setting. Prospective, comparative between techniques. General practice. Seventy-eight general practices, representative of all Italian regions, participated in this study by recruiting sequential hypertensive adults on stabilized treatment, who were subdivided into even groups with office BP, respectively, controlled or noncontrolled by treatment. In each individual, ABPM was applied by the general practitioner after appropriate training, and 24-h ABP values were defined as controlled or not according to current guidelines. Concordance between office and ABPM evaluation of BP control was assessed with kappa statistics. Positive and negative predictive values of office measurement versus ABPM were estimated. Between July 2005 and November 2006, 190 general practitioners recruited 2059 hypertensive patients based on office BP measurements; in 1728 patients, a 24-h ABPM was performed, yielding 1524 recordings considered as valid for further analysis. The agreement between the assessment of BP control by office measurement and by ABPM was poor (kappa = 0.120), with office measurements showing a satisfactory positive predictive value (0.842) and a poor negative predictive value (0.278); the situation was worse in patients with three or more among the following features: male sex, age of at least 65 years, alcohol consumption, diabetes, and obesity (negative predictive value = 0.149). In general practice, the agreement between assessment of BP control by treatment provided by office and ambulatory BP measurements is better in patients of 'uncontrolled' office BP than in 'controlled' office BP patients. This emphasizes the need for the larger use of out-of-office BP monitoring in a general practice setting, in particular, in patients considered as 'controlled' during consultation.

  3. The "Convitti Scuola della Rinascita" (The Boarding Schools of Rebirth): An Innovative Pedagogy for Democracy in Post-War Italy (1945-1955)

    ERIC Educational Resources Information Center

    Pruneri, Fabio

    2016-01-01

    In 1945, Italian society was in crisis. Twenty years of fascism and the aerial bombing and military offensives of the Second World War had left the civilian population suffering and the nation in need of reinvention. In this difficult context, certain anti-fascist intellectuals devised the interesting pedagogical experiment of the 11 Convitti…

  4. Insegnamento della lingua seconda (italiano) nella scuola primaria: l'esperienza altoatesina (Teaching Italian as a Second Language in Elementary School: The Upper Adige Experience).

    ERIC Educational Resources Information Center

    Bertocchi, Daniela

    1979-01-01

    Provides an evaluation of a 30-year experience in teaching Italian to German-speaking elementary school children in an upper northeast region of Italy. Analyzes degrees of bilingualism and sociocultural contact, emphasizing the need for culturally oriented, carefully structured materials and instruction by specially trained teachers. (MES)

  5. Un programma di calcolo per la valutazione della periodicità secondo l'analisi di Fourier. Dati temporali non equidistribuiti

    NASA Astrophysics Data System (ADS)

    Bianciardi, Giorgio

    2005-12-01

    We present and discuss a software written by us in Visual Basic to allow the search and determination of periodicity by using uneven spaced data (Date-Compensated Discrete Fourier Transform). The technique has been applied to search for the periodicity of the suspected variable star NSV 1444.

  6. Sull' Applicazione di Paradigmi della Linguistica alla Theoria dei Testi Letterari (On the Application of Linguistic Paradigms to Literary Text Theory).

    ERIC Educational Resources Information Center

    Fasoli, Paolo

    1992-01-01

    Summarizes trends over the last century of analyzing literature (poetry and prose) through the aid of linguistic theory. The contributions and shortcomings of various schools (Structuralist, Danish, Formalist, Transformationalist, Generativist) to the evaluation of literature are briefly outlined. (LET)

  7. Guida Didattica per l'Insegnamento della Matematica. Livelli G, H = Mathematics Curriculum Guide for Italian-Speaking Students, Levels G and H. Working Draft.

    ERIC Educational Resources Information Center

    Chicago Board of Education, IL. Dept. of Curriculum.

    The curriculum guide is for levels G and H of the mathematics segment of Chicago's bilingual education program for limited-English-speaking native Italian-speaking students. It includes specific instructional objectives and worksheets for teaching the mathematical concepts of place value, whole numbers, rational numbers, measurement, geometry, and…

  8. Sull' Applicazione di Paradigmi della Linguistica alla Theoria dei Testi Letterari (On the Application of Linguistic Paradigms to Literary Text Theory).

    ERIC Educational Resources Information Center

    Fasoli, Paolo

    1992-01-01

    Summarizes trends over the last century of analyzing literature (poetry and prose) through the aid of linguistic theory. The contributions and shortcomings of various schools (Structuralist, Danish, Formalist, Transformationalist, Generativist) to the evaluation of literature are briefly outlined. (LET)

  9. L'Insegnamento della Lingua Straniera per Scopi Speciali: Proposte per un Syllabus Funzionale (Teaching a Foreign Language for Specific Purposes: Ideas for a Functional Syllabus).

    ERIC Educational Resources Information Center

    Bertocchi, Daniela; Lugarini, Edoardo

    1982-01-01

    The authors stress the importance of using a "science-oriented" syllabus when teaching a second language for specific purposes and identify the linguistic concepts which must be incorporated into such a syllabus. They discuss their experience in teaching Italian for specific Purposes at the National University in Somalia. (CFM)

  10. The "Convitti Scuola della Rinascita" (The Boarding Schools of Rebirth): An Innovative Pedagogy for Democracy in Post-War Italy (1945-1955)

    ERIC Educational Resources Information Center

    Pruneri, Fabio

    2016-01-01

    In 1945, Italian society was in crisis. Twenty years of fascism and the aerial bombing and military offensives of the Second World War had left the civilian population suffering and the nation in need of reinvention. In this difficult context, certain anti-fascist intellectuals devised the interesting pedagogical experiment of the 11 Convitti…

  11. Normal behaviour of circulatory parameters during exercise. Reference values for heart rate and systemic blood pressure. The ECCIS Project data. Epidemiologia e Clinica della Cardiopatia Ischemica Silente.

    PubMed

    Menghini, F; Dally, L; Fazzini, P F; Menotti, A; Prati, P L; Rovelli, F; Antoniucci, D; Seccareccia, F

    1995-08-01

    The study of simultaneous variations in heart rate (HR) and systemic blood pressure is of great interest in ergometric practice complementing the analysis of the ST segment by ECG. This paper examines data proceeding from 500 consecutive, normal, exercise stress tests with the aim of offering reference values on the step-by-step behaviour of HR, systolic and diastolic blood pressure (SBP, DBP) during exercise in a normal population. The sample comes from a large epidemiological study (ECCIS Project) conducted on 4842 healthy, working men, aged 40-59, which proposes to identify, by a 3 stage procedure, subjects with totally asymptomatic coronary artery disease (type I silent ischemia). A further aim of our paper is to examine the influence of some physiological variables (age, height, weight, body mass index, resting HR, SBP and DBP) on the response to effort of HR, SBP and DBP; reciprocal HR/SBP adjustment during exercise; maximal attained workload and recovery time. Due to a preliminary observation that the rate of step-by-step increase in HR and SBP is inversely related to total duration, the population was split into 4 groups according to exercise tolerance (defined by maximal attained workload) to elaborate reference values. Furthermore our data demonstrate that: 1) SBP increases more rapidly with respect to HR for older and heavier subjects; 2) Exercise tolerance is inversely related to age, baseline HR and SBP, and directly related to weight and height; 3) return to baseline conditions, during recovery, is quicker for subjects with better exercise tolerance and lower baseline HR, SBP and weight.

  12. Guida Didattica per l'Insegnamento della Matematica. Livelli G, H = Mathematics Curriculum Guide for Italian-Speaking Students, Levels G and H. Working Draft.

    ERIC Educational Resources Information Center

    Chicago Board of Education, IL. Dept. of Curriculum.

    The curriculum guide is for levels G and H of the mathematics segment of Chicago's bilingual education program for limited-English-speaking native Italian-speaking students. It includes specific instructional objectives and worksheets for teaching the mathematical concepts of place value, whole numbers, rational numbers, measurement, geometry, and…

  13. [Medical prescription from "Libro de' segreti cavato da molti mastri di cristali et da altri hominij literati" Danzica 1645 (MS.5461 della Biblioteca Casanatense di Roma].

    PubMed

    Moretti, Cesare; Lucarini, Cesare

    2008-01-01

    In the Casanatense Library - Rome, few years ago, a manuscript was found, written in Danzig in 1645, containing a great number of glass recipes but also recipes of alchemic and metallurgical subject and about forty recipes of practical medicine. If the generality of recipes were published in 2004, the medical recipes are here transcribed and commented with the help of experts in pharmaceutical chemistry and in medicine history. The medicine recipes of the manuscript are typical of the therapeutic technique in use in the 17th century, deriving from an empirical knowledge and from a magic-popular heritage that accompanied the medical doctrine till modern era.

  14. L'Insegnamento della Lingua Straniera per Scopi Speciali: Proposte per un Syllabus Funzionale (Teaching a Foreign Language for Specific Purposes: Ideas for a Functional Syllabus).

    ERIC Educational Resources Information Center

    Bertocchi, Daniela; Lugarini, Edoardo

    1982-01-01

    The authors stress the importance of using a "science-oriented" syllabus when teaching a second language for specific purposes and identify the linguistic concepts which must be incorporated into such a syllabus. They discuss their experience in teaching Italian for specific Purposes at the National University in Somalia. (CFM)

  15. Sintassi e tassonomia: Teoria della valenza e lessico-grammatica in tedesco e in italiano (Syntax and Taxonomy: Theory of Valence and Lexical Grammar in German and Italian).

    ERIC Educational Resources Information Center

    Bianco, Maria Teresa

    1986-01-01

    Briefly discusses the concepts of "subject,""complement,""transitivity," and "intransitivity," contrasts the classes of complements in German and Italian based on identical criteria of classification, justifies such a classification for complements, and suggests didactic implications for the theory of…

  16. Remote sensing and GIS for the modeling of persistent organic pollutant in the marine environment

    NASA Astrophysics Data System (ADS)

    Costanzini, S.; Teggi, S.; Bigi, A.; Ghermandi, G.

    2014-10-01

    The characterization of the marine environment plays an important role in the understanding of the dynamics affecting the transport, fate and persistence (TFP) of Persistent Organic Pollutants (POPs). This work is part of a project funded by the Ministero dell'Istruzione, dell'Università e della Ricerca. The aim of the project is the assessment of the TFP of POPs in the Mediterranean sea. The analysis will be carried out at regionalmesoscale (central Mediterranean), and at local spatial scale considering different Italian test sites (the Delta of the Po River, the Venice Lagoon and the estuary of the Rio Nocella). The first step of this work involves the implementation of GIS geodatabases for the definition of the input dataset. The geodatabases were populated with MERIS and MODIS level 2 and level 3 products of Chlorophyll-a (CHL-a), Chromophoric Dissolved Organic Matter (CDOM), Aerosol Optical Thickness (AOT), Diffuse Attenuation Coefficient (DAC), Particulate Inorganic Carbon (PIC), Particulate Organic Carbon (POC) and Sea Surface Temperature (SST). The spatial scale (central Mediterranean sea) and the reference system (Plate Carrée projection) have been imposed as a constraint for the geodatabases. Four geodatabases have been implemented, two for MODIS and two for MERIS products with a monthly, seasonal and climatological temporal scale (2002 -2013). Here, we present a first application of a methodology aimed to identify vulnerable areas to POPs accumulation and persistence. The methodology allowed to assess the spatial distribution of the CHL-a in the central Mediterranean sea. The chlorophyll concentration is related to the amount of nutrients in the water and therefore provides an indicator of the potential presence of POPs. A pilot area of 300 x 200 km located in the North Adriatic sea has been initially considered. The seasonal and climatological MODIS and MERIS CHL-a variability were retrieved and compared with in-situ forcing parameters, i.e. Po River

  17. A multi-disciplinary approach for the structural monitoring of Cultural Heritages in a seismic area

    NASA Astrophysics Data System (ADS)

    Fabrizia Buongiorno, Maria; Musacchio, Massimo; Guerra, Ignazio; Porco, Giacinto; Stramondo, Salvatore; Casula, Giuseppe; Caserta, Arrigo; Speranza, Fabio; Doumaz, Fawzi; Giovanna Bianchi, Maria; Luzi, Guido; Ilaria Pannaccione Apa, Maria; Montuori, Antonio; Gaudiosi, Iolanda; Vecchio, Antonio; Gervasi, Anna; Bonali, Elena; Romano, Dolores; Falcone, Sergio; La Piana, Carmelo

    2014-05-01

    , synthetic aperture radar, optical, multispectral and panchromatic measurements), static and dynamic structural health monitoring analysis (e.g. screening tests with georadar, sonic instruments, sclerometers and optic fibers). The final purpose of the proposed approach is the development of an investigation methodology for short- and long-term Cultural Heritages preservation in response to seismic stress, which has specific features of scalability, modularity and exportability for every possible monitoring configuration. Moreover, it allows gathering useful information to furnish guidelines for Institution and local Administration to plan consolidation actions and therefore prevention activity. Some preliminary results will be presented for the test site of Calabria Region, where some architectural heritages have been properly selected as case studies for monitoring purposes. *The present work is supported and funded by Ministero dell'Università, dell'Istruzione e della Ricerca (MIUR) under the research project PON01-02710 "MASSIMO" - "Monitoraggio in Area Sismica di Sistemi Monumentali".

  18. Terrorist Motivations for the Use of Extreme Violence

    DTIC Science & Technology

    2005-05-01

    1998), 26. 17. Donatella Della Porta , Social Movements, Political Violence, and The State, (New York: Cambridge University Press, 1995), 157. 18... Donatella Della Porta , “Introduction: On Individual Motivations in Underground Political Organizations,” in Donatella Della Porta , ed., Social...Terror (NY: Reed Press, 2004), 410-419. 20. Mark Sageman, Understanding Terror Networks, (PA: Penn Press, 2004), 20. 21. Donatella Della Porta , “Left

  19. The Carrot in COIN: Effectively Utilizing the Commander’s Emergency Response Program in Irregular Warfare

    DTIC Science & Technology

    2011-03-30

    presented by Donatella della Porta in her analysis. "Left-Wing T erronsm in Italy. ൡ Della Porta traces the emergence and evolution of terrorist...General Decision B-213137. Honorable Bill Alexander Memorandum. June 22, 1984. Della Porta , Donatella . "Left-Wing Terrorism in Italy." In Terrorism...Wing Terrorism in Italy" Donatella della Porta , Pennsylvania University Press, University Park, PA: 1995, 154-159. 26 U.S. Department of the Army

  20. Political Exclusion and Violence: The Islamist movement in Egypt

    DTIC Science & Technology

    2004-09-01

    4 Donatella Della Porta , “Introduction: On Individual Motivations in Underground Political Organizations.” Social Movements and...Violence: Participation in Underground Organizations, ed. Donatella Della Porta , (Greenwich, CN: JAI Press Inc., 1992) 7. 5 Ibid., 9. 6 Ibid., 12... Della Porta , Donatella , “Introduction: On Individual Motivations in Underground Political Organizations.” Social Movements and Violence

  1. Arg72Pro polymorphism of p53 may predict poor response to medical treatment in ulcerative colitis.

    PubMed

    Vietri, Maria Teresa; Riegler, Gabriele; Pellino, Gianluca; Molinari, Anna Maria; Cioffi, Michele

    2014-01-01

    dominio ricco di proline del gene Tp53. Tale polimorfismo può determinare lo sviluppo di diversi tipi di cancro, quali il tumore della mammella, del polmone, della cervice, del colon-retto e del fegato. Studi precedenti hanno riportato un’associazione tra omozigosi Pro72 ed il decorso clinico della Colite Ulcerosa (CU).

  2. Serum cholesterol and acute myocardial infarction: a case-control study from the GISSI-2 trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto-Epidemiologia dei Fattori di Rischio dell'Infarto Miocardico Investigators.

    PubMed Central

    Nobili, A.; D'Avanzo, B.; Santoro, L.; Ventura, G.; Todesco, P.; La Vecchia, C.

    1994-01-01

    OBJECTIVE--To examine the role of serum cholesterol in acute myocardial infarction in a population of patients with no history of coronary heart disease and to establish the nature of this association, the degree of risk, and the possible interaction between serum cholesterol and other major risk factors for acute myocardial infarction. DESIGN--Case-control study. SETTING--90 hospitals in northern, central, and southern Italy. PATIENTS--916 consecutive cases of newly diagnosed acute myocardial infarction and 1106 hospital controls admitted to hospital with acute conditions not related to known or suspected risk factors for coronary heart disease. DATA COLLECTION--Data were collected with a structured questionnaire and blood samples were taken by venepuncture as soon as possible after admission to hospital from cases and controls. Blood cholesterol concentrations were available for 614 cases and 792 controls. RESULTS--After adjustment by logistic regression for sex, age, education, geographical area, smoking status, body mass index, history of diabetes and hypertension, and family history of coronary heart disease the estimated relative risks of acute myocardial infarction for quintiles of serum cholesterol (from lowest to highest) were 2.3 (95% confidence interval (CI) 1.6 to 3.4), 3.1 (95% CI 2.1 to 4.6), 4.1 (95% CI 2.8 to 6.0), and 5.2 (95% CI 3.5 to 7.7). The estimated relative risk across selected covariates increased from the lowest to the highest quintile of serum cholesterol particularly for men, patients under 55 years of age, and smokers. When the possible interaction of known risk factors with serum cholesterol was examined, smoking habits, diabetes, and hypertension had approximately multiplicative effects on relative risk. CONCLUSIONS--This study indicates that serum cholesterol was an independent risk factor for acute myocardial infarction. This association was linear, with no threshold level. Moreover, there was a multiplicative effect between cholesterol and other major risk factors on the relative risk of acute myocardial infarction. PMID:8011413

  3. Acute myocardial infarction: association with time since stopping smoking in Italy. GISSI-EFRIM Investigators. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto. Epidemiologia dei Fattori di Rischio dell'Infarto Miocardico.

    PubMed Central

    Negri, E; La Vecchia, C; D'Avanzo, B; Nobili, A; La Malfa, R G

    1994-01-01

    STUDY OBJECTIVE--The study aimed to investigate the relationship between years since stopping smoking and the risk of acute myocardial infarction. DESIGN--This was a hospital based, multicentre, case-control study conducted in Italy between September 1988 and June 1989 within the framework of the GISSI-2 clinical trial. SETTING--Over 80 coronary care units in various Italian regions participated. SUBJECTS--A total of 916 incident cases of acute myocardial infarction, below age 75 years, and with no history of ischaemic heart disease, and 1106 control subjects admitted to the same hospitals for acute, non-neoplastic, cardiovascular or cerebrovascular conditions that were not known or suspected to be related to cigarette smoking took part in the study. MAIN OUTCOME MEASURES AND RESULTS--Measures were relative risk (RR) estimates of acute myocardial infarction according to the time since stopping smoking and adjusted for identified potential confounding factors. Compared with never smokers, the multivariate RRs were 1.6 (95% confidence interval (CI) 0.8,3.2) for subjects who had given up smoking for one year; 1.4 (95% CI 0.9,2.1) for those who had stopped for two to five years; 1.2 (95% CI 0.7,2.1) for six to 10 years; and 1.1 (95% CI 0.8,1.8) for those who had not smoked for over 10 years. The estimated RR for current smokers was 2.9 (95% CI 2.2,3.9). The risks of quitters were higher for heavier smokers and those below age 50 years, while no difference emerged in relation to the duration of smoking, sex, and other risk factors for myocardial infarction. CONCLUSIONS--These results indicate that there is already a substantial drop in the risk of acute myocardial infarction one year after stopping. The risk in ex-smokers, however, seemed higher (although not significantly) than that of those who had never smoked, even more than 10 years after quitting. This could support the existence of at least two mechanisms linking cigarette smoking with acute myocardial infarction--one involving thrombogenesis or spasms that occurs over the short term, and another involving atherosclerosis that is a long term effect. PMID:8189165

  4. Dall'italo-austrliano all'italiano: apprendmento linguistico fra gli scolari della seconda generazione (From Italian-Australian to Italian: Language Acquisition among the Students of the Second Generation).

    ERIC Educational Resources Information Center

    Rubino, Antonia

    1989-01-01

    Discusses the results of research to determine the success of the efforts currently being made in schools to teach pure Italian to the second generation of Italians in Australia in order to replace Italian Australian, a mixture of Italian dialects, Italian, and English. 33 references. (CFM)

  5. Clinical recommendations of cardiac magnetic resonance, Part II: inflammatory and congenital heart disease, cardiomyopathies and cardiac tumors: a position paper of the working group 'Applicazioni della Risonanza Magnetica' of the Italian Society of Cardiology.

    PubMed

    Pontone, Gianluca; Di Bella, Gianluca; Silvia, Castelletti; Maestrini, Viviana; Festa, Pierluigi; Ait-Ali, Lamia; Masci, Pier Giorgio; Monti, Lorenzo; di Giovine, Gabriella; De Lazzari, Manuel; Cipriani, Alberto; Guaricci, Andrea I; Dellegrottaglie, Santo; Pepe, Alessia; Marra, Martina Perazzolo; Aquaro, Giovanni D

    2017-04-01

    The current document was developed by the working group on the 'application of cardiac magnetic resonance' of the Italian Society of Cardiology to provide a perspective on the current state of technical advances and clinical cardiac magnetic resonance applications and to inform cardiologists how to implement their clinical and diagnostic pathway with the introduction of this technique in the clinical practice. Appropriateness criteria were defined using a score system: score 1-3 = inappropriate (test is not generally acceptable and is not a reasonable approach for the indication), score 4-6 = uncertain (test may be generally acceptable and may be a reasonable approach for the indication but more research and/or patient information is needed to classify the indication definitively) and score 7-9 = appropriate (test is generally acceptable and is a reasonable approach for the indication).

  6. Clinical recommendations of cardiac magnetic resonance, Part I: ischemic and valvular heart disease: a position paper of the working group 'Applicazioni della Risonanza Magnetica' of the Italian Society of Cardiology.

    PubMed

    Aquaro, Giovanni Donato; Di Bella, Gianluca; Castelletti, Silvia; Maestrini, Viviana; Festa, Pierluigi; Ait-Ali, Lamia; Masci, Pier Giorgio; Monti, Lorenzo; di Giovine, Gabriella; De Lazzari, Manuel; Cipriani, Alberto; Guaricci, Andrea I; Dellegrottaglie, Santo; Pepe, Alessia; Marra, Martina Perazzolo; Pontone, Gianluca

    2017-04-01

    Cardiac magnetic resonance (CMR) has emerged as a reliable and accurate diagnostic tool for the evaluation of patients with cardiac disease in several clinical settings and with proven additional diagnostic and prognostic value compared with other imaging modalities. This document has been developed by the working group on the 'application of CMR' of the Italian Society of Cardiology to provide a perspective on the current state of technical advances and clinical applications of CMR and to inform cardiologists on how to implement their clinical and diagnostic pathways with the inclusion of this technique in clinical practice. The writing committee consisted of members of the working group of the Italian Society of Cardiology and two external peer reviewers with acknowledged experience in the field of CMR.

  7. Sintassi e Tassonomia: Teoria della valenza e lessico-grammatica in tedesco e in italiano (III) (Syntax and Taxonomy: Theory of Valence and Lexical Grammar in German and Italian, Part 3).

    ERIC Educational Resources Information Center

    Bianco, Maria Teresa

    1987-01-01

    In this article, the author concludes a three-part series in which she analyzes verb complements in German and Italian. Parts 1 and 2 of the series appear in volume 18, numbers 2 and 3, respectively. (CFM)

  8. La teoria dell'attivita verbale nella fase attuale e il suo significato nell'insegnamento della lingua russa agli stranieri (The Theory of Verbal Activity in its Present Stage and its Significance in the Teaching of Russian to Foreigners)

    ERIC Educational Resources Information Center

    Leont'ev, A. A.

    1977-01-01

    Traces the evolution of thought in the field of psycholinguistics ("theory of verbal activity" in Russia) and discusses current research being done in the United States, Europe, and the Soviet Union. A valid method of teaching language cannot be developed without a theory of language acquisition. (Text is in Italian.) (CFM)

  9. "Una Communita" Poco Nota della Communicazione non Verbale: Come Communicano il Direttore e l'Orchestra (A Little Known "Community" of Nonverbal Communication: How the Conductor and Orchestra Communicate).

    ERIC Educational Resources Information Center

    Leonardi, Magda Farago

    1992-01-01

    Examines how conductors and orchestras communicate. Communication is essentially nonverbal. Conductors use gestures, gaze, facial expression, nods and posture to deliver their message. Norbert Weiner's Cybernetic Theory of human communication is seen as a means of analyzing precisely how this musical communication takes place. (16 references) (LET)

  10. "Una Communita" Poco Nota della Communicazione non Verbale: Come Communicano il Direttore e l'Orchestra (A Little Known "Community" of Nonverbal Communication: How the Conductor and Orchestra Communicate).

    ERIC Educational Resources Information Center

    Leonardi, Magda Farago

    1992-01-01

    Examines how conductors and orchestras communicate. Communication is essentially nonverbal. Conductors use gestures, gaze, facial expression, nods and posture to deliver their message. Norbert Weiner's Cybernetic Theory of human communication is seen as a means of analyzing precisely how this musical communication takes place. (16 references) (LET)

  11. Presupposti teorici per un progetto di insegnamento della traduzione dalla lingua straniera basato sull'analisi testuale (Theoretical Presuppositions for a Project to Teach Translation from a Foreign Language Based on Textual Analysis).

    ERIC Educational Resources Information Center

    Horrakh, Livio

    1987-01-01

    Discusses an approach to translation based on textual linguistics. The student/translator first looks at the foreign language text as a whole, then analyzes its parts, and finally arrives at a new synthesis (the translation) that is comparable to the original text. (CFM)

  12. Presupposti teorici per un progetto di insegnamento della traduzione dalla lingua straniera basato sull'analisi testuale (Theoretical Presuppositions for a Project to Teach Translation from a Foreign Language Based on Textual Analysis).

    ERIC Educational Resources Information Center

    Horrakh, Livio

    1987-01-01

    Discusses an approach to translation based on textual linguistics. The student/translator first looks at the foreign language text as a whole, then analyzes its parts, and finally arrives at a new synthesis (the translation) that is comparable to the original text. (CFM)

  13. Reviewing the upper Pleistocene human footprints from the 'Sala dei Misteri' in the Grotta della Bàsura (Toirano, northern Italy) cave: An integrated morphometric and morpho-classificatory approach

    NASA Astrophysics Data System (ADS)

    Paolo Citton; Romano, Marco; Salvador, Isabella; Avanzini, Marco

    2017-08-01

    About thirty human footprints made approximately 12,000 years B.P. inside the 'Sala dei Misteri' Cave of Básura near Toirano, Liguria, northern Italy, were studied by standard ichnological analysis. Eleven of the best-preserved tracks were examined further using morpho-classificatory and morphometric approaches, in order to estimate the minimum number of trackmakers; biometric measurements were also used to tentatively determine their physical characteristics (e.g., height and age). Results indicate at least three different producers, two youths and the third of tender age. Analysis of the data demonstrate the power of 3D, of landmark-based morphometrics, and the utility of methods of forensic anthropology in the determination of human footprints. The study of the number of trackmakers using the principal component analysis (PCA) on 'multi-trampling' surfaces could represent a model in the ichnological study of cave sites.

  14. Dall'italo-austrliano all'italiano: apprendmento linguistico fra gli scolari della seconda generazione (From Italian-Australian to Italian: Language Acquisition among the Students of the Second Generation).

    ERIC Educational Resources Information Center

    Rubino, Antonia

    1989-01-01

    Discusses the results of research to determine the success of the efforts currently being made in schools to teach pure Italian to the second generation of Italians in Australia in order to replace Italian Australian, a mixture of Italian dialects, Italian, and English. 33 references. (CFM)

  15. Prognostic significance of heart rate variability in post-myocardial infarction patients in the fibrinolytic era. The GISSI-2 results. Gruppo Italiano per lo Studio della Sopravvivenza nell' Infarto Miocardico.

    PubMed

    Zuanetti, G; Neilson, J M; Latini, R; Santoro, E; Maggioni, A P; Ewing, D J

    1996-08-01

    Studies performed before the introduction of fibrinolysis showed that a low heart rate variability (HRV) is associated with higher mortality in post-myocardial infarction (MI) patients. We evaluated whether HRV adds information relevant to risk stratification in patients treated with fibrinolysis as well. From 24-hour ECG recordings obtained at discharge in patients treated with recombinant tissue-type plasminogen activator or streptokinase, we measured several time-domain indexes of HRV: standard deviation (SDNN), root-mean-square of successive differences (RMSSD), and number of RR interval increases > 50 ms ("NN50+"). The prognostic value of HRV for total and cardiovascular mortality was assessed. Of 567 patients with valid recordings, 52 (9.1%) died during the 1000 days of follow-up, 44 (7.8%) of cardiovascular causes. All indexes of low HRV were able to identify patients (16% to 18% of total population) with a higher total mortality (20.8% to 24.2% versus 6.0% to 6.8%, depending on index used). The independent predictive value of low HRV was confirmed by the adjusted analysis with the following relative risks: NN50+, 3.5 (95% CI, 1.9 to 6.7); SDNN, 3.0 (95% CI, 1.55 to 5.9); and RMSSD, 2.8 (95% CI, 1.5 to 5.3). Advanced age, previous MI, Killip class at entry, and use of digitalis were also independent predictors. Similar data were obtained for cardiovascular mortality. Time-domain indexes of HRV retain their independent prognostic significance even in post-MI patients of all ages treated with fibrinolysis.

  16. Role of interactions between psychological and clinical factors in determining 6-month mortality among patients with acute myocardial infarction. Application of recursive partitioning techniques to the GISSI-2 database. Gruppo Italiano per lo Studio della Sopravvivenza nell' Infarto Miocardico.

    PubMed

    Carinci, F; Nicolucci, A; Ciampi, A; Labbrozzi, D; Bettinardi, O; Zotti, A M; Tognoni, G

    1997-05-01

    Clinical and epidemiological studies support the hypothesis that ischaemic cardiovascular diseases are consistently associated with psychological, social and behavioural factors. Nevertheless, the joint effect of clinical characteristics and psychological variables in determining the prognosis of acute myocardial infarction survivors has been seldom investigated. In the framework of the GISSI-2 trial, the impact of psychological factors on 6-month mortality and their interaction with clinical features was included as an ad hoc research project. Overall, 2449 patients were evaluated, 63 of whom died during the study period. All patients undertook a self-administered questionnaire (Cognitive Behavioural Assessment Hospital Form), investigating 16 psychological dimensions relative to three areas (state variables, vital exhaustion, trait variables). The impact of psychological variables on prognosis and their interaction with clinical variables were investigated by using a tree-growing technique (RECursive Partitioning and AMalgamation-RECPAM) applied to survival analysis. This statistical method allowed the identification of three separate classes, characterized by different prognoses: Class I (presence of vital exhaustion), Class II (concomitance of no vital exhaustion, depression and low levels of anxiety) and Class III (all other patients). After adjusting for the clinical variables, Class I was associated with an intermediate prognosis (hazard ratio [HR] = 2.2; 95% confidence intervals [CI], 1.2-4.0) and Class II to the worst (HR = 3.2; 95% CI = 1.6-6.2), as compared to Class III. High levels of neuroticism and extroversion were associated with a better prognosis. When clinical and psychological variables were simultaneously investigated by RECPAM, Type A behaviour was shown to be an important risk predictor among patients with better clinical conditions, i.e. those eligible for exercise test (HR = 2.6, 95% CI = 1.2-5.5). Finally, a striking difference in the impact of the most predictive clinical variables (exercise test ineligibility, late and early ventricular failure) was found among patients with and without vital exhaustion. This study shows that acute myocardial infarction survivors are heterogeneous with respect to 6-month mortality according to their psychological profile. More important, the impact of these variables appears comparable to that of very well known clinical risk predictors. The availability of a large study population, together with the use of innovative statistical techniques, allowed us to identify subgroups of patients for whom the joint action of clinical and psychological characteristics has been clearly documented. This suggests the need for incorporating psychological evaluation in the care of acute myocardial infarction patients.

  17. Studiar L'inglese dalle elementari--Problema europeo: Una proposta nuova della pedagogia cibernetica (Beginning the Study of English in the Elementary School Grades--A European Problem: A New Proposal from Cibernetic Education).

    ERIC Educational Resources Information Center

    Chiti-Batelli, Andrea

    1986-01-01

    Warns the European community of the dangers of accepting English as the international language and urges the adoption of Esperanto, a neutral language without its own cultural tradition, as the international lingua franca. (CFM)

  18. Studiar L'inglese dalle elementari--Problema europeo: Una proposta nuova della pedagogia cibernetica (Beginning the Study of English in the Elementary School Grades--A European Problem: A New Proposal from Cibernetic Education).

    ERIC Educational Resources Information Center

    Chiti-Batelli, Andrea

    1986-01-01

    Warns the European community of the dangers of accepting English as the international language and urges the adoption of Esperanto, a neutral language without its own cultural tradition, as the international lingua franca. (CFM)

  19. Le osservazioni per la determinazione della curva di luce del pianetino 44 Nysa effettuate all'osservatorio del Collegio Romano da E. Bianchi ed E. Padova nel periodo 1913 - 1921.

    NASA Astrophysics Data System (ADS)

    Calabresi, M.

    1993-04-01

    The author describes the observations of minor planet 44 Nysa effected at the Observatory of the Collegio Romano by E. Bianchi and E. Padova in the years 1913 - 1921. The light curves obtained point out a periodical brightness variation with amplitude of 0.35 magnitudes.

  20. Neuropsychological assessment of the severely impaired elderly patient: validation of the Italian short version of the Severe Impairment Battery (SIB). Gruppo di Studio sull'Invecchiamento Cerebrale della Società Italiana di Gerontologia e Geriatria.

    PubMed

    Pippi, M; Mecocci, P; Saxton, J; Bartorelli, L; Pettenati, C; Bonaiuto, S; Cucinotta, D; Masaraki, G; Neri, M; Tammaro, A E; Vergani, C; Chionne, F; Senin, U

    1999-08-01

    One hundred and sixty-nine severely demented patients were tested in a multicenter study with the short version of the Severe Impairment Battery which was translated into Italian with the purpose of adapting and validating it for an Italian population. Patients were enrolled in Italian geriatric centers participating in the Study Group on Aging Brain of the Italian Society of Gerontology and Geriatrics. Following thorough clinical and instrumental examinations, they were evaluated with the Mini Mental State Examination, the Clinical Dementia Rating, the Severe Impairment Battery (SIB), the Gottfries-Bråne-Steen Rating Scale for Dementia, the Activity of Daily Living index, and the Bedford Alzheimer Nursing Severity scale (BANS.s). The inter-rater reliability of the SIB was highly significant for the total score and its subtests; test-retest reliability showed the same significance in all items. Also concurrent validity, performed comparing the total SIB score with the total BANS.s score, was significant. The short Italian version of the SIB proved to be a very reliable tool for the evaluation of severely demented patients; it has the advantage of being easy to administer, it evaluates more cognitive domains that, are typically assessed in dementia, and has a wide enough range of scores to detect even small differences in the examined abilities.

  1. Serum cholesterol and acute myocardial infarction: a case-control study from the GISSI-2 trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto-Epidemiologia dei Fattori di Rischio dell'Infarto Miocardico Investigators.

    PubMed

    Nobili, A; D'Avanzo, B; Santoro, L; Ventura, G; Todesco, P; La Vecchia, C

    1994-05-01

    To examine the role of serum cholesterol in acute myocardial infarction in a population of patients with no history of coronary heart disease and to establish the nature of this association, the degree of risk, and the possible interaction between serum cholesterol and other major risk factors for acute myocardial infarction. Case-control study. 90 hospitals in northern, central, and southern Italy. 916 consecutive cases of newly diagnosed acute myocardial infarction and 1106 hospital controls admitted to hospital with acute conditions not related to known or suspected risk factors for coronary heart disease. Data were collected with a structured questionnaire and blood samples were taken by venepuncture as soon as possible after admission to hospital from cases and controls. Blood cholesterol concentrations were available for 614 cases and 792 controls. After adjustment by logistic regression for sex, age, education, geographical area, smoking status, body mass index, history of diabetes and hypertension, and family history of coronary heart disease the estimated relative risks of acute myocardial infarction for quintiles of serum cholesterol (from lowest to highest) were 2.3 (95% confidence interval (CI) 1.6 to 3.4), 3.1 (95% CI 2.1 to 4.6), 4.1 (95% CI 2.8 to 6.0), and 5.2 (95% CI 3.5 to 7.7). The estimated relative risk across selected covariates increased from the lowest to the highest quintile of serum cholesterol particularly for men, patients under 55 years of age, and smokers. When the possible interaction of known risk factors with serum cholesterol was examined, smoking habits, diabetes, and hypertension had approximately multiplicative effects on relative risk. This study indicates that serum cholesterol was an independent risk factor for acute myocardial infarction. This association was linear, with no threshold level. Moreover, there was a multiplicative effect between cholesterol and other major risk factors on the relative risk of acute myocardial infarction.

  2. Physical activity and the risk of acute myocardial infarction. GISSI-EFRIM Investigators. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto-Epidemiologia dei Fattori di Rischio dell'Infarto Miocardico.

    PubMed

    D'Avanzo, B; Santoro, L; La Vecchia, C; Maggioni, A; Nobili, A; Iacuitti, G; Franceschi, S

    1993-11-01

    The relationship between physical activity and acute myocardial infarction (AMI) was examined in a case-control study conducted in Italy in 1988 to 1989 within the framework of the GISSI-2 trial of streptokinase versus alteplase and heparin versus no heparin in the treatment of AMI. A total of 916 case patients admitted to coronary care units from various Italian regions for AMI were interviewed. Control subjects were 1106 patients admitted to the same network of hospitals for a broad spectrum of acute diseases not related to known or potential risk factors for myocardial infarction. Among various types of physical activity (occupational activity, walking, stair climbing, and sport and leisure-time physical activity), occupational physical exercise emerged as the most protective. Multivariate odds ratios (ORs) were 1.4 (95% confidence interval (CI), 1.0 to 2.0) and 1.6 (95% CI, 1.2 to 2.1) for the two lowest levels of occupational physical activity. The trends of increasing risk with decreasing activity were consistent, although less strong, when other types of activity were considered. The protection conveyed by occupational physical activity was similar across various strata of sex, age, education, smoking habits, and diabetes, and was not explained by serum cholesterol, body weight, or hypertension. This study therefore confirms that low physical activity is an indicator of subsequent risk of AMI.

  3. Cigarette smoking and acute myocardial infarction. A case-control study from the GISSI-2 trial. GISSI-EFRIM Investigators. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto--Epidemiologia dei Fattori di Rischio dell'infarto Miocardioco.

    PubMed

    Negri, E; La Vecchia, C; Nobili, A; D'Avanzo, B; Bechi, S

    1994-08-01

    To make a further quantitative assessment of the relationship between cigarette smoking and the risk of myocardial infarction, a multicentric case-control study was conducted in Italy between September 1988 and June 1989 within the framework of the GISSI-2 trial. Ninety hospitals in various Italian Regions participated. 916 cases of acute myocardial infarction with no history of ischaemic heart disease and 1106 controls admitted to hospital for acute conditions not related to known or suspected risk factors for ischaemic heart disease were studied. Relative risks (RR) and 95% confidence intervals (CI) of myocardial infarction according to various measures of tobacco smoking, were adjusted for identified potential confounding factors using multiple logistic regression. Compared to lifelong non-smokers, the RR was 1.3 (95% CI 1.0 to 1.9) for ex-smokers, 2.0 (95% CI 1.4 to 2.9) for current smokers of less than 15 cigarettes per day, 3.1 (95% CI 2.2 to 4.2) for 15-24 cigarettes per day and 4.9 (95% CI 3.4 to 7.1) for 25 or more cigarettes per day. No trend in risk was evident for the duration, the RR being around 3 for subsequent categories. There was a significant interaction between smoking and age. Below the age 45, smokers of 25 or more cigarettes per day had a 33 times higher risk than non-smokers, compared to 7.5 at in the age group 45-54, 4.4 between the ages 55-64 and 2.5 at the age of 65 or over. The risk estimates were higher in women (RR for > or = 25 cigarettes per day = 10.1), in subjects in the lowest cholesterol tertile (RR = 11.9), with no history of diabetes (RR = 6.8), hypertension (RR = 9.5), no family history ischaemic heart disease (RR = 9.1) and low body mass index (RR = 9.3). The importance of smoking is confirmed as a cause of acute myocardial infarction: about 50% of all nonfatal infarctions in this Italian population could be attributable to cigarette smoking.(ABSTRACT TRUNCATED AT 250 WORDS)

  4. Attributable risks for nonfatal myocardial infarction in Italy. GISSI-EFRIM investigators. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico. Epidemiologia dei Fattori di Rischio dell'Infarto Miocardico.

    PubMed

    Negri, E; La Vecchia, C; Franzosi, M G; Tognoni, G

    1995-11-01

    The proportions of nonfatal acute myocardial infarctions (AMI) in Italy attributable to cigarette smoking, body mass, serum cholesterol level, hypertension, diabetes, and family history of AMI (attributable risks, AR) were estimated using data from a case-control study on 614 incident cases of AMI before age 75 with no history of ischemic heart disease and 792 control subjects admitted to the same hospitals where cases were identified for acute, nonneoplastic, cardio- or cerebrovascular conditions not known or suspected to be related to cigarette smoking. The study was conducted between September 1988 and June 1989 within the framework of the GISSI-2 clinical trial. We assumed a multiplicative model and thus the risk attributable to several factors combined is not the sum of those attributable to the single factors. Overall the AR of smoking was 49%, and for cholesterol, body mass, family history of AMI, hypertension, and diabetes the AR were 49, 16, 14, 13, and 6%, respectively. Together these factors explained 85% of AMI cases. Though differences emerged for each single factor, the proportion of AMI explained by the six factors together was approximately the same for both sexes, while these factors accounted for 97% of AMI cases before age 50 (and smoking alone for 70%) and for 80% after age 50. This study confirms that interventions on well-defined risk factors could, in principle, lead to the avoidance of the great majority of myocardial infarctions in this population (i.e., about 80% before age 75 and about 95% before age 50).

  5. Coffee consumption and risk of acute myocardial infarction in Italian males. GISSI-EFRIM. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto, Epidemiologia dei Fattori di Rischio del'Infarto Miocardico.

    PubMed

    D'Avanzo, B; La Vecchia, C; Tognoni, G; Franceschi, S; Franzosi, M G; Nobili, A; Santoro, L; Scarsi, G

    1993-11-01

    The relationship between coffee consumption and acute myocardial infarction (AMI) was analyzed using data from a case-control study conducted in 1988 to 1989 within the framework of the GISSI-2 trial on streptokinase versus alteplase and heparin versus no heparin in the treatment of AMI. A total of 801 male patients with AMI and 792 control subjects who were hospitalized in several Italian regions for diseases unrelated to known or potential risk factors for cardiovascular diseases were included. Compared with coffee nondrinkers, the multivariate relative risks (RRs), after allowance for age, education, body mass index, smoking habits, alcohol consumption, family history of AMI, cholesterol level, history of diabetes, and hypertension, were 0.8 (95% confidence interval (CI), 0.5 to 1.2) for consumption of one cup/d, 1.3 (95% CI, 0.9 to 2.0) for two cups/d, 1.8 (95% CI, 1.1 to 2.7) for three cups, 2.5 (95% CI, 1.5 to 4.1) for four cups, and 2.6 (95% CI, 1.6 to 4.2) for five cups or more. The trend in risk with dose was statistically significant (P < 0.001). Duration of coffee consumption was not associated with the risk of AMI. The RRs for daily coffee consumption were elevated across strata of various covariates, including age, smoking habits, cholesterol level, diabetes, and hypertension, with a particularly elevated (although not significantly heterogeneous) estimate in patients younger than 50 years (RR, 5.7; 95% CI, 3.0 to 10.9 for four or more cups/d). The RR in patients who drank four or more cups of coffee per day and were current smokers was 8.1 (95% CI, 5.1 to 13.0), suggesting an unfavorable effect on the combination of cigarette smoking and high coffee intake on the risk of AMI.

  6. Frequency of consumption of selected indicator foods and serum cholesterol. GISSI-EFRIM investigators. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto--Epidemiologia dei Fattori di Rischio dell'Infarto Miocardico.

    PubMed

    D'Avanzo, B; Negri, E; Nobili, A; La Vecchia, C

    1995-06-01

    The relationship between frequency of consumption of eleven indicator foods (milk, meat, liver, carrots, green vegetables, fruit, eggs, ham, fish, cheese and alcohol) and serum cholesterol was investigated in the comparison group of a case-control study of acute myocardial infarction conducted in Italy. Data were collected on 792 subjects from various Italian regions, admitted to hospital for acute conditions unrelated to any known or potential risk factor for myocardial infarction or to long-term modifications in diet. No statistically or epidemiologically meaningful relationship emerged between serum cholesterol level and frequency of consumption of any of these foods. Cholesterol levels rose according to increasing consumption tertiles for most of the indicator foods considered. Higher values for the higher tertile of consumption were observed for meat, ham and eggs, but also for fruit, carrots and green vegetables. However, correlation coefficients between frequency of consumption of various food items and serum cholesterol level were uniformly low for all food items considered, ranging between -0.09 (for milk) and 0.19 (for ham). Although a more comprehensive diet history may lead to different indications, the present data are not suggestive of any major influence of long-term frequency of consumption of a few selected indicator foods on serum cholesterol levels.

  7. Acute myocardial infarction: association with time since stopping smoking in Italy. GISSI-EFRIM Investigators. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto. Epidemiologia dei Fattori di Rischio dell'Infarto Miocardico.

    PubMed

    Negri, E; La Vecchia, C; D'Avanzo, B; Nobili, A; La Malfa, R G

    1994-04-01

    The study aimed to investigate the relationship between years since stopping smoking and the risk of acute myocardial infarction. This was a hospital based, multicentre, case-control study conducted in Italy between September 1988 and June 1989 within the framework of the GISSI-2 clinical trial. Over 80 coronary care units in various Italian regions participated. A total of 916 incident cases of acute myocardial infarction, below age 75 years, and with no history of ischaemic heart disease, and 1106 control subjects admitted to the same hospitals for acute, non-neoplastic, cardiovascular or cerebrovascular conditions that were not known or suspected to be related to cigarette smoking took part in the study. Measures were relative risk (RR) estimates of acute myocardial infarction according to the time since stopping smoking and adjusted for identified potential confounding factors. Compared with never smokers, the multivariate RRs were 1.6 (95% confidence interval (CI) 0.8,3.2) for subjects who had given up smoking for one year; 1.4 (95% CI 0.9,2.1) for those who had stopped for two to five years; 1.2 (95% CI 0.7,2.1) for six to 10 years; and 1.1 (95% CI 0.8,1.8) for those who had not smoked for over 10 years. The estimated RR for current smokers was 2.9 (95% CI 2.2,3.9). The risks of quitters were higher for heavier smokers and those below age 50 years, while no difference emerged in relation to the duration of smoking, sex, and other risk factors for myocardial infarction. These results indicate that there is already a substantial drop in the risk of acute myocardial infarction one year after stopping. The risk in ex-smokers, however, seemed higher (although not significantly) than that of those who had never smoked, even more than 10 years after quitting. This could support the existence of at least two mechanisms linking cigarette smoking with acute myocardial infarction--one involving thrombogenesis or spasms that occurs over the short term, and another involving atherosclerosis that is a long term effect.

  8. La teoria dell'attivita verbale nella fase attuale e il suo significato nell'insegnamento della lingua russa agli stranieri (The Theory of Verbal Activity in its Present Stage and its Significance in the Teaching of Russian to Foreigners)

    ERIC Educational Resources Information Center

    Leont'ev, A. A.

    1977-01-01

    Traces the evolution of thought in the field of psycholinguistics ("theory of verbal activity" in Russia) and discusses current research being done in the United States, Europe, and the Soviet Union. A valid method of teaching language cannot be developed without a theory of language acquisition. (Text is in Italian.) (CFM)

  9. Sintassi e Tassonomia: Teoria della valenza e lessico-grammatica in tedesco e in italiano (III) (Syntax and Taxonomy: Theory of Valence and Lexical Grammar in German and Italian, Part 3).

    ERIC Educational Resources Information Center

    Bianco, Maria Teresa

    1987-01-01

    In this article, the author concludes a three-part series in which she analyzes verb complements in German and Italian. Parts 1 and 2 of the series appear in volume 18, numbers 2 and 3, respectively. (CFM)

  10. Wild 2 grains characterized combining MIR/FIR/Raman micro-spectroscopy and FE-SEM/EDS analyses

    NASA Astrophysics Data System (ADS)

    Ferrari, M.; Rotundi, A.; Rietmeijer, F. J. M.; Della Corte, V.; Baratta, G. A.; Brunetto, R.; Dartois, E.; Djouadi, Z.; Merouane, S.; Borg, J.; Brucato, J. R.; Le Sergeant d'Hendecourt, L.; Mennella, V.; Palumbo, M. E.; Palumbo, P.

    and, if so, which fraction of the dust in these comets is truly represented by non-processed silicates and organic material. The work done for Stardust samples is important to understand the similarities and differences among comets. In fact, the results of this study are relevant also for the ROSETTA mission that encountered the Jupiter-Family (J-F) comet 67P/Churyumov-Gerasimenko in August, 2014. At the time this mission was launched, our ideas of comet dust were biased by the findings of the Halley missions. The Stardust mission showed an unexpected richness of dust that originated from the inner solar system. Rosetta is confirming these results but also adding information, in particular on the presence of a primitive and unprocessed dust component \\cite{Fulle15}. The work was supported by PRIN2008/MIUR (Ministero dell'Istruzione dell'Università e della Ricerca), the Italian Space Agency (ASI), and MAE (Ministero degli Affari Esteri). The IAS team is grateful to the French space agency CNES for funding and supporting this work as well as to the CNRS PNP planetology program. FJMR was supported by grant NNX11AC36G through the NASA LARS Program. We thank the NASA Johnson Space Center/Astromaterials Curation laboratory for providing the samples.

  11. A S.M.A.R.T. system for the seismic vulnerability mitigation of Cultural Heritages

    NASA Astrophysics Data System (ADS)

    Montuori, Antonio; Costanzo, Antonio; Gaudiosi, Iolanda; Vecchio, Antonio; Minasi, Mario; Falcone, Sergio; La Piana, Carmelo; Stramondo, Salvatore; Casula, Giuseppe; Giovanna Bianchi, Maria; Fabrizia Buongiorno, Maria; Musacchio, Massimo; Doumaz, Fawzi; Ilaria Pannaccione Apa, Maria

    2016-04-01

    enable assessing the site seismic effects, the built-up structural features and the surface deformation processes of the local-scale area on a monthly temporal span; c) the real- to near-real-time and building scale analysis of the heritage through proximal remotely sensing tools (e.g. terrestrial laser scanning, infrared thermal cameras and real aperture radar), combined with ambient vibration tests. They allow analyzing geometric, structural and material properties / anomalies of buildings as well as the state of conservation of structures on a real-time temporal span. The proposed approach is: Specific (it targets the cultural heritages monitoring for seismic mitigation purposes); Measurable (it provides synthetic descriptors or maps able to quantify structural and the environmental properties / anomalies / trends); Action-oriented (it provides information to plan consolidation and restoration actions for prevention activity); Relevant (it allows achieving consolidated results for cultural heritage monitoring); Time-related (it specifies when the results can be achieved). Meaningful results, obtained for the Saint Augustine Complex (XVI century) located in the historic center of the Calabrian chief town of Cosenza, are presented in terms of a web-based Geographic Information System (GIS) platform and a 3-dimensional (3D) visual software for the monitoring of environmental/urban landscapes and buildings. These tools represent the added-value products of the proposed SMART system, which allow integrating and combining multi-sensors analyses in order to support end-users involved into a cultural heritage monitoring. * The present work is supported and funded by Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR) under the research project PON01-02710 "MASSIMO" - "Monitoraggio in Area Sismica di Sistemi Monumentali".

  12. WaveSAX device: design optimization through scale modelling and a PTO strategical control system

    NASA Astrophysics Data System (ADS)

    Peviani, Maximo; Danelli, Andrea; Dadone, Gianluca; Dalmasso, Alberto

    2017-04-01

    simulating four wave conditions previously tested in the ocean tank at the ECN (Nantes, France). The results showed a satisfactory behaviour of the system and allowed to define the optimal velocity and torque conditions to maximize the PTO. REFERENCES 1. M. Peviani, 2015, 'WAVESAX device: conceptual design and perspectives', 8th European Seminar OWEMES 2015, Offshore Wind and other marine renewable Energies in Mediterranean and European Seas, Rome, Italy 2. B. Holmes, K. Nielsen, 2010, Guidelines for the Development & Testing of Wave Energy Systems, OES-IA Annex II Task 2.1, Report T02-2.1 3. G. Agate, A. Amicarelli, M. Peviani, 2014, 'Analisi fluidodinamica di un prototipo per la conversione di energia da moto ondoso: ottimizzazione della componente fissa e stime preliminari di potenza assorbita con la girante', RSE Ricerca di Sistema, Report 14001669 4. G. Agate, A. Amicarelli, A. Danelli, M. Peviani, 2015, 'Ottimizzazione del disegno di un dispositivo di generazione d'energia dal moto ondoso: simulazioni numeriche e studi in vasca di laboratorio idraulico, RSE Ricerca di Sistema, Report 15000671 5. A. Agate, A. Amicarelli, A. Danelli, M. Peviani, 2015. 'Optimization of the WaveSAX device: numerical modelling and ocean wave basin tests', VI International Conference on Computational Methods in Marine Engineering MARINE 2015, Rome, Italy 6. A. Danelli, M. Peviani, 2016. 'Performance evaluation of an innovative device to transform wave power into electric energy in ports and harbours". CORE 2nd International Conference on Offshore Renewable Energy; Glasgow, UK 7. M. Peviani, A. Danelli, G. Agate, F. Thiebaut, 2014, 'WAVETUBE RSE1, addressed to test an innovative device to transform wave power into electric energy in ports and harbours', Infrastructure post access report in the MARINET project framework 8. M. Peviani, A. Danelli, G. Agate, S. Bourdier, 2015, WAVESAX RSE2, addressed to test an innovative device to transform wave power into electric energy in ports and harbours

  13. The Banality of Islamist Politics

    DTIC Science & Technology

    2004-06-01

    1988. Dahm, Bernhard. History of Indonesia in the Twentieth Century. New York: Praeger Publishers, 1971. Della Porta , Donatella . “Recruitment...New York: Praeger Publishers, 1971. 96 Della Porta , Donatella . “Recruitment Processes in Clandestine Political Organizations: Italian Left-Wing...2003: 72. 24 Della Porta 1988: 159. 25 Hafez: 75. 26 Ibid: 75. 10 rebellion.27 That is, “armed insurgencies result from the violent suppression of

  14. Islamic Insurgency and Transnational Terrorism in Thailand: Analysis and Recommended Solution Strategy

    DTIC Science & Technology

    2005-06-01

    government must find alternative approaches to dismantling the militant infrastructure. Donatella Della Porta (1995), author of Social Movements...experience and governments can exploit. In general, Della Porta explains that as organizations become more clandestine as a result of increased government...downward spiral” that Dell Porta describes seems like a very appropriate description of events. In the end, Della Porta explains that members of the

  15. Assessing the Effectiveness of Deradicalization Programs for Islamist Extremists

    DTIC Science & Technology

    2009-12-01

    1987), 25. 20 Ibid., 31. 21 Ibid. 22 Ibid. 23 Ibid., 44. 24 Ibid., 53–57. 25 Donatella della Porta , “Leaving Underground Organizations, A...Oaks: Sage Publications, 1996. della Porta , Donatella . “Leaving Underground Organizations, A Sociological Analysis of the Italian Case.” In Leaving...from underground, violent, political groups. In a study of terrorists and underground political groups in Italy, della Porta found that the higher

  16. Subversion and Insurgency

    DTIC Science & Technology

    2007-01-01

    Crenshaw, ed., Ter- rorism in Context, University Park, Penn.: Pennsylvania State University Press, 1995. della Porta , Donatella , “Recruitment...predisposes individuals to involvement in terrorist groups.” 6 Subversion and Insurgency (quoted in della Porta , 1988, p. 34). Finally, blood...Leites, 1979, p. 32. In della Porta’s (1988) study of Italian left-wing terrorism, she notes that “previous experience in violent political activities

  17. American Muslims: Living the Dream

    DTIC Science & Technology

    2008-05-27

    2005). 7 See Donatella Della Porta and Mario Diani, Social Movements: An Introduction, (Oxford: Blackwell Publishing, 1999). 8 behavior would prevent...communities within Western Europe and America. 67 See See Donatella Della Porta and Mario...ehost/delivery?vid=4&hid=7&sid=b6f92f53-38be-4af3-971a- 10 (accessed February 15, 2008). Della Porta , Donatella and Mario Diani. Social Movements

  18. Lessons on Policing Terrorism: Studying Police Effectiveness in Italy and Germany

    DTIC Science & Technology

    2011-12-01

    Summer 2004): 77. 12 Donatella Della Porta , “Institutional Responses to Terrorism: The Italian Case,” Terrorism and Political Violence 4, no. 4...American Sociologist 35, no. 2 (Summer 2004): 75–92. Della Porta , Donatella . “Institutional Responses to Terrorism: The Italian Case.” Terrorism...Comparison of Structures.” In Social Movements and Violence: Participation in Underground Organizations, by Donatella Della Porta , 237–257. Greenwich

  19. Measures of Effectiveness: Israeli Counterterrorism Strategies and Tactics During the Al-Aqsa Intifada

    DTIC Science & Technology

    2006-09-01

    34 Donatella Della Porta , uses changes "in legislation, the policy of the police apparatus, and the actual activities of the security forces and courts...Lanham: University Press of America, 1984), 35. 10 Donatella Della Porta , "Institutional Responses to Terrorism, The Italian Case" Western...from http://www.defense- update.com/directory/THEL.htm; Internet; accessed 27 July 2006. Della Porta , Donatella "Institutional Responses to

  20. The Race Against Nuclear Terror

    DTIC Science & Technology

    2005-09-01

    Organizational Approaches,” 26. 110 Donatella Della Porta , Social Movements, Political Violence, and the State, (New York: Cambridge University...Jenkins. The Threat of Nuclear Terrorism: A Reexamination. Santa Monica, CA: RAND Corporation, N-2706, 1985. 115 Della Porta , Donatella . “Introduction...edited by Donatella Della Porta , 3-28. Greenwich, CT: JAI Press, 1992. _______. Social Movements, Political Violence, and the State. New York

  1. Functional characterization and developmental expression profiling of gibberellin signalling components in Vitis vinifera

    PubMed Central

    Acheampong, Atiako Kwame; Hu, Jianhong; Rotman, Ariel; Zheng, Chuanlin; Halaly, Tamar; Takebayashi, Yumiko; Jikumaru, Yusuke; Kamiya, Yuji; Lichter, Amnon; Sun, Tai-Ping; Or, Etti

    2015-01-01

    Gibberellins (GAs) regulate numerous developmental processes in grapevine (Vitis vinifera) such as rachis elongation, fruit set, and fruitlet abscission. The ability of GA to promote berry enlargement has led to its indispensable use in the sternospermocarpic (‘seedless’) table grape industry worldwide. However, apart from VvGAI1 (VvDELLA1), which regulates internode elongation and fruitfulness, but not berry size of seeded cultivars, little was known about GA signalling in grapevine. We have identified and characterized two additional DELLAs (VvDELLA2 and VvDELLA3), two GA receptors (VvGID1a and VvGID1b), and two GA-specific F-box proteins (VvSLY1a and VvSLY1b), in cv. Thompson seedless. With the exception of VvDELLA3-VvGID1b, all VvDELLAs interacted with the VvGID1s in a GA-dependent manner in yeast two-hybrid assays. Additionally, expression of these grape genes in corresponding Arabidopsis mutants confirmed their functions in planta. Spatiotemporal analysis of VvDELLAs showed that both VvDELLA1 and VvDELLA2 are abundant in most tissues, except in developing fruit where VvDELLA2 is uniquely expressed at high levels, suggesting a key role in fruit development. Our results further suggest that differential organ responses to exogenous GA depend on the levels of VvDELLA proteins and endogenous bioactive GAs. Understanding this interaction will allow better manipulation of GA signalling in grapevine. PMID:25588745

  2. Functional characterization and developmental expression profiling of gibberellin signalling components in Vitis vinifera.

    PubMed

    Acheampong, Atiako Kwame; Hu, Jianhong; Rotman, Ariel; Zheng, Chuanlin; Halaly, Tamar; Takebayashi, Yumiko; Jikumaru, Yusuke; Kamiya, Yuji; Lichter, Amnon; Sun, Tai-Ping; Or, Etti

    2015-03-01

    Gibberellins (GAs) regulate numerous developmental processes in grapevine (Vitis vinifera) such as rachis elongation, fruit set, and fruitlet abscission. The ability of GA to promote berry enlargement has led to its indispensable use in the sternospermocarpic ('seedless') table grape industry worldwide. However, apart from VvGAI1 (VvDELLA1), which regulates internode elongation and fruitfulness, but not berry size of seeded cultivars, little was known about GA signalling in grapevine. We have identified and characterized two additional DELLAs (VvDELLA2 and VvDELLA3), two GA receptors (VvGID1a and VvGID1b), and two GA-specific F-box proteins (VvSLY1a and VvSLY1b), in cv. Thompson seedless. With the exception of VvDELLA3-VvGID1b, all VvDELLAs interacted with the VvGID1s in a GA-dependent manner in yeast two-hybrid assays. Additionally, expression of these grape genes in corresponding Arabidopsis mutants confirmed their functions in planta. Spatiotemporal analysis of VvDELLAs showed that both VvDELLA1 and VvDELLA2 are abundant in most tissues, except in developing fruit where VvDELLA2 is uniquely expressed at high levels, suggesting a key role in fruit development. Our results further suggest that differential organ responses to exogenous GA depend on the levels of VvDELLA proteins and endogenous bioactive GAs. Understanding this interaction will allow better manipulation of GA signalling in grapevine. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  3. Influence of Progressive Central Hypovolemia on Multifractal Dimension of Cardiac Interbeat Intervals

    DTIC Science & Technology

    2010-05-07

    and 5 Istituto Fisiologia Clinica, CNR-Area Ricerca San Cataldo, Via Moruzzi 1, 56124-Pisa (Dated: May 7, 2010) Abstract We analyzed the heartbeat time...the research group of prof. B Ghe- larducci, Dipartimento di Fisiologia e Biochimica, Universitá di Pisa, and Dr. M. Varanini, Institute of Clinical

  4. Genetic Modifiers of Ovarian Cancer

    DTIC Science & Technology

    2014-08-01

    Special Functions, IRCCS AOU San Martino–IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy, 126 UO Anatomia Patologica, Ospedale di...Athens, Greece (Yannoukakos, Fostira); Instituto de Genética Humana , Pontificia Universidad Javeriana, Bogotá, Colombia (Torres); Molecular Genetics of

  5. Papuan Ethno-Political Conflict: Causes, Contexts, and Policy Implications

    DTIC Science & Technology

    2004-03-01

    Donatella Della Porta and Herbert Reiter, ed., Policing Protests: The Control of Mass Demonstrations in Western Democracies (Minneapolis: University of...http://www.c- r.org/ccts/ccts9/vipolint.htm] (March 2004). Donatella Della Porta and Herbert Reiter, ed., Policing Protests: the Control of Mass

  6. Understanding Proto-Insurgencies

    DTIC Science & Technology

    2007-01-01

    Richard, “The Liberal Impulse in Saudi Arabia,” The Middle East Journal, Vol. 57, No. 3, Summer 2003, pp. 400–413. Della Porta , Donatella , “Left Wing...example of this, see Della Porta (1995, pp. 126–127). 25 CHAPTER SIX Defeating Proto-Insurgencies One of the most important factors in combating proto

  7. Growth and Yield of Thinned Yellow-Poplar

    Treesearch

    Donald E. Beck; Lino Della-Bianca

    1972-01-01

    Diameter distributions and yields for various combinations of site index, age, and density for unthinned and largely undisturbed stands of yellow-poplar (Liriodendron tulipifera L. ) have been presented by McGee and Della-Bianca (1967) and Beck and Della-Bianca (1970). Their results were based on the initial measurements of a network of permanent sample plots...

  8. America’s last battles: Organizing brigades to win the peace lessons from East Timor, Afghanistan, and Iraq

    DTIC Science & Technology

    2004-06-17

    Motor Maniacs”: an Inter-War Defense of Horse Cavalry. Armor (March-April): 12-15. Della Porta , Donatella . 1995. Left-Wing Terrorism in Italy. In...Brigade members ( Della Porta 1995, 119). Political reforms and improved economic conditions may slightly decrease support for revolutionary terrorist

  9. Understanding Proto-Insurgencies

    DTIC Science & Technology

    2007-01-01

    Dekmejian, Richard, “The Liberal Impulse in Saudi Arabia,” The Middle East Journal, Vol. 57, No. 3, Summer 2003, pp. 400–413. Della Porta , Donatella , “Left...ethnic example of this, see Della Porta (1995, pp. 126–127). 25 CHAPTER SIX Defeating Proto-Insurgencies One of the most important factors in combating

  10. An Integrated Approach to Counter Insurgency: A Burundi Case Study

    DTIC Science & Technology

    2012-03-20

    2012. 27 Donatella Della Porta , Terrorism in Context (University Park, PA: The Pennsylvania States University Press, 1995), 156. 28Frederick...the protests has contributed to give a supplementary reason for insurgency. As Della Porte clearly notes it, “state repression 12 is a key

  11. Combating Terrorism: Are There Lessons to Be Learned from Foreign Experiences

    DTIC Science & Technology

    2002-01-18

    7 Donatella della Porta . “Left-Wing Terrorism in Italy” in Terrorism in Context, op. cit. p 159. 8 “Terrorism and Public Opinion: A Five Country...lacking other kinds of resources but possessing the skills necessary for a greater use of violence.” Donatella della Porta . “Left-Wing Terrorism in

  12. Understanding Why Terrorist Operations Succeed or Fail

    DTIC Science & Technology

    2009-01-01

    Operations Succeed or Fail della Porta , Donatella , “Left-Wing Terrorism in Italy,” in Martha Crenshaw, ed., Terrorism in Context, University Park, Pa...recognized for some time. For example, see discussion in della Porta , 1995 and Strinkowski, 1985, pp. 94–99, that explains the limits of hierarchical control

  13. Learning On-Line from a Few Examples

    DTIC Science & Technology

    2009-08-31

    3192, Spring 2009 LaStampa.it Tecnologia News, Tomaso Poggio, uno dei padri della neuroscienza e professore al MIT di Boston: "I robot non saranno una...LOGGIA, Levanto, Italy (July 16, 2004): "Geni e Memi" - Incontro Dibattito: Scienza e Futuro della Nostra Societa - Tomaso Poggio. MIT NEWS OFFICE

  14. A COMPARATIVE STUDY OF TWO F-BOX PROTEINS, SLEEPY1 AND SNEEZY IN GA SIGNALING

    USDA-ARS?s Scientific Manuscript database

    SNEEZY (SNE) is a homolog of SLEEPY1 (SLY1), encoding an F-box protein subunit of an SCF E3 ubiquitin ligase complex in Arabidopsis. SLY1 plays a central role in destruction of DELLA negative family proteins via 26S proteasome pathway in GA signaling pathway. DELLA proteins consist of five memb...

  15. Perspectives of Phase-Portraits in the Detection of Compressor Instabilities-Inception of Stall

    DTIC Science & Technology

    2001-06-01

    della teoria del caos Young eds. Springer, Berlin 1981, page 366. deterministo." PhD Thesis, Universita Degli Studi Di 36. Theiler J.; "Estimating...34, Funzionamento di un Compressore Assiale in Ann. Math. 37, page 645. Prossimita’ dello stallo rotante secondo le tecniche della Teoria dcl Caos

  16. Gibberellin Perception by the Gibberellin Receptor and its Effector Recognition

    NASA Astrophysics Data System (ADS)

    Hakoshima, Toshio; Murase, Kohji; Hirano, Yoshinori; Sun, Tai-Ping

    Gibberellins control a diverse range of growth and developmental processes in higher plants and have been widely utilized in the agricultural industry. By binding to a nuclear receptor GIBBERELLIN INSENSITIVE DWARF1 (GID1), gibberellins regulate gene expression by promoting degradation of the transcriptional regulator DELLA proteins. The precise manner in which GID1 discriminates and becomes activated by bioactive gibberellins for specific binding to DELLA proteins remains unclear. We present the crystal structure of a ternary complex of Arabidopsis thaliana GID1A, a bioactive gibberellin and the N-terminal DELLA domain of GAI. In this complex, GID1a occludes gibberellin in a deep binding pocket covered by its N-terminal helical switch region, which in turn interacts with the DELLA domain containing DELLA, VHYNP and LExLE motifs. Our results establish a structural model of a plant hormone receptor which is distinct from the hormone-perception mechanism and effector recognition of the known auxin receptors.

  17. Gibberellins Regulate Ovule Integument Development by Interfering with the Transcription Factor ATS1[OPEN

    PubMed Central

    Sacristan, Raquel

    2016-01-01

    Gibberellins (GAs) are plant hormones that regulate most plant life cycle aspects, including flowering and fruit development. Here, we demonstrate the implication of GAs in ovule development. DELLA proteins, negative GA response regulators, act as positive factors for ovule integument development in a mechanism that involves transcription factor ABERRANT TESTA SHAPE (ATS). The seeds of the della global mutant, a complete loss-of-function of DELLA, and the ats-1 mutant are remarkably similar, with a round shape, a disorganized testa, and viviparism. These defects are the result of an alteration in integuments that fail to fully develop and are shorter than in wild-type plants. ats-1 also shows some GA-related phenotypes, for example, higher germination rates and early flowering. In fact, ats-1 has elevated GA levels due to the activation of GA biosynthesis genes, which indicates that ATS inhibits GA biosynthesis. Moreover, DELLAs and ATS proteins interact, which suggests the formation of a transcriptional complex that regulates the expression of genes involved in integument growth. Therefore, the repression of GA biosynthesis by ATS would result in the stabilization of DELLAs to ensure correct ATS-DELLA complex formation. The requirement of both activities to coordinate proper ovule development strongly argues that the ATS-DELLA complex acts as a key molecular factor. This work provides the first evidence for a role of GAs in ovule and seed development. PMID:27794102

  18. [Knowledge and common sense of nurses on the health's inequities: an exploratory study.

    PubMed

    Cotichelli, Giordano; Di Meo, Giorgia; Giampieri, Paolo

    2016-01-01

    Introduzione. I dati statistici per il 2015 parlano di un peggioramento generale delle condizioni di vita e di salute della popolazione in Italia. Le possibili ricadute chiamano l’infermiere ad un coinvolgimento in tema di disuguaglianze nella salute. Lo studio è stato realizzato con lo scopo di valutare quanto gli infermieri conoscono e percepiscono la correlazione fra le condizioni di salute della popolazione e le iniquità di sistema. Metodo. E’ stato condotto uno studio esplorativo attraverso un aggiornamento bibliografico rispetto a precedenti lavori e la somministrazione di questionari a campioni di convenienza di professionisti e studenti di infermieristica e valutazione dei risultati secondo la prospettiva del mixed method. Risultati. La bibliografia infermieristica presente sul piano quantitativo è molto limitata. Il questionario fornisce risposte utili alla valutazione della percezione delle disuguaglianze nella salute in termini di equità orizzontale e verticale. Conclusioni. La conoscenza delle disuguaglianze nella salute non può essere al margine dei lavori scientifici e della stessa letteratura professionale. E’ necessario ridurre il divario fra gli aspetti valoriali propri della professione, che riverberano nella percezione delle iniquità esistenti, e l’assunzione piena del sapere correlato ai determinanti socio-economici della salute e della malattia.

  19. A panchromatic view of the evolution of Supermassive Black Holes

    NASA Astrophysics Data System (ADS)

    Lusso, E.; Brusa, M.; Comastri, A.; Vignali, C.; Gilli, R.

    2008-10-01

    Verranno presentati i risultati preliminari di uno studio sistematico delle distribuzioni di energia spettrale (SED) di un campione statisticamente significativo di alcune centinaia di AGN (sia di tipo 1 che di tipo 2) selezionati dalla survey XMM-COSMOS. La vasta mole di dati disponibili sull'intero spettro elettromagnetico permette di calcolare le SED medie per diversi intervalli di redshift e luminosita'. Una stima affidabile della SED e' di fondamentale importanza per il calcolo della luminosita' bolometrica e quindi per lo studio della fisica dei processi di accrescimento su SMBH, per la loro evoluzione con il tempo cosmico.

  20. Modello di Sviluppo dei Fattori Cognitivo-Linguistici della Tautologia, Sinonimia et Antonimia nei Bambini dei 3 a 6 Anni di Eta (Developmental Models of Tautology, Synonymy, and Antonymy as Cognitive-Linguistic Factors in Children from 3 to 6 Years of Age).

    ERIC Educational Resources Information Center

    Aprile, Luigi

    1992-01-01

    Tests and confirms hypothesis that a four-stage process exists in the understanding and use of synonyms, antonyms, and tautologies in children ages three to six. The results of this study challenge widely held theories on cognitive development. (45 references) (LET)

  1. La Segmentazione Grafica della Scrittura di una Storia Conosciuta. Uno Studio Descrittivo su 450 Testi di Bambini dai 6 agli 8 Anni (Graphic Segmentation of the Writing of a Familiar Story. A Descriptive Study of 450 Texts of Children from 6 to 8 Years Old).

    ERIC Educational Resources Information Center

    Pontecorvo, Clotilde; Di Eduardo, Roberta

    1995-01-01

    The purpose of this study was to analyze how children in the early grades of elementary school divide words while writing. The subjects were 450 Italian children belonging either to upper-middle-class or lower-middle-class families who were asked to write the familiar story of "Little Red Riding Hood." (CFM)

  2. Prognostic significance of double product and inadequate double product response to maximal symptom-limited exercise stress testing after myocardial infarction in 6296 patients treated with thrombolytic agents. GISSI-2 Investigators. Grupo Italiano per lo Studio della Sopravvivenza nell-Infarto Miocardico.

    PubMed

    Villella, M; Villella, A; Barlera, S; Franzosi, M G; Maggioni, A P

    1999-03-01

    The aim of this study was to evaluate the prognostic significance of the pressure-rate product (PRP) obtained during exercise stress testing and of its change from rest to maximal exercise (dPRP) in a population of survivors of acute myocardial infarction treated with thrombolytic agents. Survivors of acute myocardial infarction (n = 6251) from the GISSI-2 database, who underwent a maximal symptom-limited exercise test with either bicycle ergometer or treadmill, were followed up for 6 months. PRP and dPRP values were dichotomized (21,700, 11,600, respectively) and analyzed in a multivariate Cox model individually and simultaneously with other ergometric variables. Six-month mortality rate was 0.8% in the high PRP group and 2.0% in the low PRP group. Low PRP was an independent predictor of 6-month mortality rate (relative risk [RR] 1.97, 95% confidence interval [CI] 1.24 to 3.13). Patients with low dPRP had mortality rates higher than patients with high dPRP (2.1% vs 0.8%). At the multivariate analysis, low dPRP showed negative predictive value (RR 1.97, 95% CI 1.23 to 3.16). A further multivariate analysis was performed with PRP and dPRP, also adjusting for low work capacity, abnormal systolic blood pressure response to exercise, and symptomatic-induced ischemia. The results showed that low work capacity, low PRP, and symptomatic exercise-induced ischemia were still significantly associated with higher 6-month mortality rate (P =.04,.02, and.05; RR = 1.68, 1.71, and 1.78 respectively). PRP is a predictive index to assess prognosis in survivors of acute myocardial infarction treated with thrombolytic agents able to perform an exercise test after acute myocardial infarction, but its usefulness appears to be limited, considering that these patients were at low risk.

  3. HISTOPATHOLOGY OF THE DUODENAL-JEJUNAL MUCOSA OBTAINED BY CROSBY BIOPSY IN A CASE OF NUTRITIONAL MEGALOBLASTIC ANEMIA FOLIC ACID-RESPONSIVE (ISTOPATOLOGIA DELLA MUCOSA DUODENODIGIUNALE OTTENUTA CON BIOPSIA ALLA CROSBY IN UN CASO DI ANEMIA MEGALOBLASTICA NUTRIZIONALE FOLICO-RESPONSIVA),

    DTIC Science & Technology

    In a nutritional megaloblastic anemia case, responsive to folic acid, partial or subtotal atrophy of the villi was observed in the duodenal-jejunal... villous tunica and of the pericryptic area, the presence of pseudocrypts, alterations of the glandular acini, and hyperplasia of the interstitial

  4. Bioacoustic Characterization of the Mediterranean Sea SOLMAR

    DTIC Science & Technology

    2004-09-01

    ambient noise and cetaceans acoustic activity all day round; radio-linked sonobuoys were also used to monitor specific areas or when arrays were not...activity of animals. Acoustic monitoring was performed mainly with towed arrays 24h/24h to provide information on ambient noise and cetaceans acoustic...crociere di ricerca nel Mediterraneo con lo scopo di studiare il comportamento acustico dei cetacei e le loro relazioni con 1’ ambiente circostante

  5. GPS/Galileo Interoperability: GGTO, Timing Biases, and Giove-A Experience

    DTIC Science & Technology

    2007-01-01

    Ricerca Metrologica (INRiM), Turin, Italy Jörg Hahn Galileo Project Office, ESA/ ESTEC , Noordwijk , The Netherlands Abstract The future...steered to UTC/TAI, and a Processing Center located at the European Space Agency (ESA- ESTEC ) in The Netherlands. The latter was used for the generation...pseudorange and carrier phase measurements to a Ground Processing Center (GPC) located at ESTEC (upgraded from GSTB-V1). One station is to be installed at

  6. L'eliosismologia: onde sismiche per studiare l'interno del Sole

    NASA Astrophysics Data System (ADS)

    Di Mauro, M. P.

    2014-12-01

    Negli ultimi cinquanta anni siamo stati testimoni di una straordinaria rivoluzione della conoscenza e comprensione della nostra stella grazie alla nascita dell'Eliosismologia, lo studio delle oscillazioni solari. Analogamente a ciò che accade nella Terra durante i terremoti, anche l'interno del Sole è pervaso continuamente da onde sismiche che provocano piccole oscillazioni, ovvero deformazioni della fotosfera. Le oscillazioni sono la manifestazione di diversi processi che avvengono all'interno della struttura del Sole e le frequenze sismiche dei modi osservati e misurati sulla superficie sono legate direttamente ai parametri fisici degli strati interni attraversati dalle onde sismiche. Lo studio delle oscillazioni rappresenta, quindi, l'unico metodo diretto per studiare la struttura e la dinamica interna del Sole. In questo articolo verranno illustrate le caratteristiche generali delle oscillazioni solari e verranno presentati i risultati importanti e i progressi notevoli raggiunti grazie all'Eliosismologia.

  7. La relatività debole. La fisica dello spazio e del tempo senza paradossi

    NASA Astrophysics Data System (ADS)

    Selleri, Franco

    2011-06-01

    Secondo Einstein e Poincaré la simultaneità di eventi che hanno luogo in punti diversi dello spazio può essere definita solo per convenzione. Dal punto di vista matematico si dimostra, quindi, che due diverse definizioni di simultaneità corrispondono a due diversi valori del coefficiente e1 della variabile spaziale x presente nelle trasformazioni di Lorentz. A partire da premesse normalmente accettate otterremo diverse dimostrazioni della necessità di reintrodurre il concetto di simultaneità assoluta. Le conseguenze cosmologiche della nuova struttura dello spazio e del tempo andranno contro la cosmologia del Big Bang. Inoltre, dopo questi risultati, il relativismo sopravviverà in una forma meno aspra ("relatività debole") perché risulter privo di quel campionario di paradossi portato dalla teoria della Relatività Speciale.

  8. Deep burn of hand and forearm treated by abdominal wall flap. A case report.

    PubMed

    Chiummariello, Stefano; Del Torto, Giuseppe; Maffia, Romano; Pataia, Elisabetta; Alfano, Carmine

    2015-06-24

    Le ustioni della mano sono sempre state uno dei maggiori problemi per i chirurghi ricostruttori a causa della sua particolare anatomia e delle sue complesse funzioni. Una guarigione spontanea di lesioni profonde in queste aree può portare a risultati catastrofici: una copertura cutanea adeguata è fondamentale per tutte le funzioni. La copertura precoce dei tessuti molli residuanti è fondamentale al fine di evitare la formazione di contratture disabilitanti che con il tempo potrebbero determinare anchilosi articolare e retrazione tendinea. Escissione precoce e innesti cutanei rappresentano la terapia standard per le ustioni della mano; in alcuni casi quest’approccio è inapplicabile e, pertanto, il ricorso ai lembi diventa inevitabile. In questo articolo riportiamo un caso di ustione complessa del dorso della mano trattata in prima istanza con innesti cutanei e, quindi, con un lembo addominale, riuscendo ad ottenere un’ottima copertura ed un buon recupero delle funzioni.

  9. The Italian Army and Effects-Based Operations: A New Concept for an Army of Use

    DTIC Science & Technology

    2005-05-25

    efficiently42. 41 Ministero della Difesa, Libro Bianco 2002 (Roma: Stabilimento Grafico Militare...GUARDIAN/. Internet; accessed 22 March 2006. __________. Libro Bianco 2002. Roma: Stabilimento grafico Militare, 2001. __________. Nuove Forze per un

  10. Sentinel node radioguided biopsy in surgical management of the medullary thyroid carcinoma A case report.

    PubMed

    Boni, Giuseppe; Mazzarri, Sara; Grosso, Mariano; Manca, Giampiero; Biricotti, Marco; Ambrosini, Carlo Enrico; Fregoli, Lorenzo; Puccini, Marco; Caldarelli, Claudio; Spisni, Roberto

    2014-01-21

    Il carcinoma midollare della tiroide è raro. Il suo trattamento è chirurgico e consiste in una tiroidectomia totale associata a dissezione dei linfonodi centrali. L’opportunità della linfoadenectomia dei linfonodi cervicali laterali è argomento controverso. Per ridurre l’estensione della dissezione dei linfonodi laterocervicali ai casi in cui tale procedura sia effettivamente necessaria abbiamo eseguito la tecnica della biopsia del linfonodo sentinella, già praticata in altra patologia tumorale, in un caso di carcinoma midollare, sporadico, diagnosticato con ecografia, determinazione dei livelli di calcitonina serica e citologia dell’agoaspirato. All’ecografia non si evidenziavano linfonodi cervicali centrali o laterali. Abbiamo eseguito mappaggio preoperatorio dei linfonodi sentinella iniettando Tecnezio 99-m nel nodulo tiroideo. La paziente è stata poi sottoposta a tiroidectomia totale e biopsia radioguidata dei linfonodi sentinella. L’esame istologico ha confermato la presenza di un carcinoma midollare della tiroide e di micrometastasi in due linfonodi sentinella situati nel compartimento laterale destro. Dopo la tiroidectomia l’intervento è stato completato con dissezione dei compartimenti centrale e laterala destro. Al followup non sono stati rilevati livelli di calcitonina serica nè basali nè dopo stimolazione con pentagastrina. Si tratta del primo caso, riportato in letteratura, che dimostra l’utilità della biopsia radioguidata del linfonodo sentinella nella stadiazione linfonodale e del trattamento chirurgico del microcarcinoma midollare della tiroide. Tale biopsia può essere utile ad eseguire la dissezione linfonodale laterale solo nei pazienti con provato coinvolgimento dei linfonodi laterali del collo e quindi a ridurre l’entità della dissezione e delle relative complicanze.

  11. Redescription of two European species of Acerentomidae (Protura) belonging to the Italian fauna.

    PubMed

    Galli, Loris; Capurro, Matteo; Costa, Fabio; Stadio, Gabriele Di; Sarà, Antonio; Zinni, Matteo

    2016-08-22

    Acerentulus apuliacus Rusek & Stumpp, 1988 is redescribed based on new specimens collected in Apulia and Basilicata (S-Italy) and deposited in the collection of Geneva Natural History Museum. Podolinella ruseki (Nosek, 1967) new combination is redescribed, based on the holotype from Austria and additional specimens collected in Liguria, NW Italy. The new material is deposited in the collection of the Dipartimento di Scienze della Terra, dell'Ambiente e della Vita, University of Genoa.

  12. How Terrorist Groups End: Studies of the Twentieth Century

    DTIC Science & Technology

    2010-01-01

    main source is the detailed research in Donnatella della Porta , “Left Wing Terrorism in Italy,” in Terrorism in Context, ed. Martha Crenshaw...the office of Rep. James A. Courter (R-NJ) on the House Armed Services Committee, where I also had the honor of employment. 49. Donatella della ... Porta , “Left-Wing Terrorism in Italy,” in Terrorism in Context, ed. Martha Crenshaw (University Park: Pennsylvania State University Press, 1995), 121. 50

  13. A Theory of State Behavior under Threat: The Tragedy of Domestic Realism

    DTIC Science & Technology

    2007-03-01

    New York University Press, 1997); Steven Pinker, The Blank Slate: The Modern Denial of Human Nature (New York: Penguin, 2002). 9 Donatella Della ...United Methodist Church. The Truth about Kent State: A Challenge to the American Conscience. New York: Farrar Straus Giroux, 1973. Della Porta ... Porta , Social Movements, Political Violence, and the State: A Comparative Analysis of Italy and Germany (New York: Cambridge University Press, 1995

  14. The Explanatory Value of Social Movement Theory

    DTIC Science & Technology

    2005-03-01

    Social Movement Theory Approach (Bloomington, IN: Indiana University Press, 2004). 5. Wiktorowicz, 2004, Ibid. , 9. 6. Della Porta , Donatella ...34Introduction: On Individual Motivations in Underground Political Organizations," in Donatella Della Porta , ed., Social Movements and Violence...1 (1993): 47-71; Donatella , Op. Cit., 3-28. 19. Robinson, Op. Cit. 20. Wiktorowicz, Quintan, "Framing Jihad: Intra-Movement Framing Contests and Al

  15. Cost Structure and Life Cycle Costs for Military Systems

    DTIC Science & Technology

    2003-09-01

    Česká republika Ryvangs Allé 1, P.O. Box 2715 Centro di Documentazione DK-2100 Copenhagen Ø Tecnico -Scientifica della Difesa ROYAUME-UNI Via XX...ITALY ARGE Dairesi Başkanliği (MSB) DENMARK Centro di Documentazione 06650 Bakanliklar - Ankara Danish Defence Research Tecnico -Scientifica della...categories of support elements are broadly common for all kinds of system. They include: Data: all deliverable data and publications, e.g., manuals

  16. Metastasis of the gallbladder from the breast cancer.

    PubMed

    Fleres, Francesco; Rossitto, Maurizio; Foti, Agata; Macrì, Antonio; Cucinotta, Eugenio

    2014-12-29

    Le lesioni metastatiche della colecisti costituiscono una condizione clinica non frequente. Nella maggior parte dei casi si tratta di metastasi da melanoma, da tumore renale e da tumori della cervice. Lesioni metastatiche colecistiche da tumore primitivo della mammella sono descritte raramente in letteratura. In questa nota viene presentato il caso di una donna di 83 anni, sottoposta ad intervento chirurgico di colecistectomia videolaparoscopica (VL) per colelitiasi, con riscontro all’esame istologico del pezzo operatorio di una lesione di tipo metastatico Il carcinoma della mammella ed in particolare la varietà istologica duttale infiltrante si associa con elevata frequenza a metastasi loco-regionali e a distanza, quest’ultime a carico di ossa, fegato, polmone e SNC. Lesioni metastatiche a carico del tratto gastrointestinale, del peritoneo, del retroperitoneo e della pelvi possono essere causate soprattutto dal carcinoma lobulare invasivo, variante istologica meno frequente rispetto al tumore duttale rappresentando circa il 10% di tutti i carcinomi mammari. In questa nota è stata condotta una analisi dei dati della Letteratura sulle lesioni secondarie della colecisti da carcinoma della mammella che ha permesso di confermare la rarità di tale patologia descritta solamente in 18 pazienti: 12 di origine lobulare infiltrante, 1 di origine duttale e 2 misto duttale e lobulare infiltrante. La prognosi del carcinoma mammario metastatico è considerato incerto e spesso infausto. Clinicamente è difficile sospettare una localizzazione metastatica da carcinoma mammario primario nella colecisti, ma riteniamo che sia necessario conoscere bene questa possibilità di metastasi e da tenere a mente durante il follow-up di pazienti con cancro al seno. Sebbene la colecistectomia sia considerata come trattamento palliativo nelle pazienti con metastasi alla colecisti da carcinoma mammario, è consigliabile nei casi sintomatici.

  17. Adaptive Control Allocation for Fault Tolerant Overactuated Autonomous Vehicles

    DTIC Science & Technology

    2007-11-01

    Alessandro Casavola and Emanuele Garone Dipartimento di Elettronica, Informatica e Sistemistica, Università della Calabria 87037 Arcavacata di Rende...Informatica e Sistemistica, Universit‘a della Calabria 87037 Arcavacata di Rende - (CS), Italy 8. PERFORMING ORGANIZATION REPORT NUMBER 9...7-07, Univrsity of Calabria , DEIS, 2007. Adaptive Control Allocation for Fault Tolerant Overactuated Autonomous Vehicles RTO-MP-AVT-145 3.2 - 15

  18. The GID1-Mediated Gibberellin Perception Mechanism Is Conserved in the Lycophyte Selaginella moellendorffii but Not in the Bryophyte Physcomitrella patens[W

    PubMed Central

    Hirano, Ko; Nakajima, Masatoshi; Asano, Kenji; Nishiyama, Tomoaki; Sakakibara, Hitoshi; Kojima, Mikiko; Katoh, Etsuko; Xiang, Hongyu; Tanahashi, Takako; Hasebe, Mitsuyasu; Banks, Jo Ann; Ashikari, Motoyuki; Kitano, Hidemi; Ueguchi-Tanaka, Miyako; Matsuoka, Makoto

    2007-01-01

    In rice (Oryza sativa) and Arabidopsis thaliana, gibberellin (GA) signaling is mediated by GIBBERELLIN-INSENSITIVE DWARF1 (GID1) and DELLA proteins in collaboration with a GA-specific F-box protein. To explore when plants evolved the ability to perceive GA by the GID1/DELLA pathway, we examined these GA signaling components in the lycophyte Selaginella moellendorffii and the bryophyte Physcomitrella patens. An in silico search identified several homologs of GID1, DELLA, and GID2, a GA-specific F-box protein in rice, in both species. Sm GID1a and Sm GID1b, GID1 proteins from S. moellendorffii, showed GA binding activity in vitro and interacted with DELLA proteins from S. moellendorffii in a GA-dependent manner in yeast. Introduction of constitutively expressed Sm GID1a, Sm G1D1b, and Sm GID2a transgenes rescued the dwarf phenotype of rice gid1 and gid2 mutants. Furthermore, treatment with GA4, a major GA in S. moellendorffii, caused downregulation of Sm GID1b, Sm GA20 oxidase, and Sm GA3 oxidase and degradation of the Sm DELLA1 protein. These results demonstrate that the homologs of GID1, DELLA, and GID2 work in a similar manner in S. moellendorffii and in flowering plants. Biochemical studies revealed that Sm GID1s have different GA binding properties from GID1s in flowering plants. No evidence was found for the functional conservation of these genes in P. patens, indicating that GID1/DELLA-mediated GA signaling, if present, differs from that in vascular plants. Our results suggest that GID1/DELLA-mediated GA signaling appeared after the divergence of vascular plants from the moss lineage. PMID:17965273

  19. The Vaiont Slide. A Geotechnical Analysis Based on New Geologic Observations of the Failure Surface. Volume 2. Appendices A through G

    DTIC Science & Technology

    1985-06-01

    Italian Published by Museo Tridentino di Sclenze Naturall Via Rosmini n. 39 Trento, 1965 G1 - -, --------------- INDEX A. Introduction...del bacino del Vaiont che i1 9 ottobre 1963 fu interessata dal disastroso fenomeno di scivolamento. Mentre per una esauriente trattazione geologica si... fenomeno di movimento lento durato circa tre anni, e sulle ragioni della sua improvvisa trasformazione nell’inaspettato velocissinio slittamento della

  20. Word-level Alignment for Multilingual Resource Acquisition

    DTIC Science & Technology

    2002-04-01

    SUBTITLE Word-level Alignment for Multilingual Resource Acquisition 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Word-level Alignment for Multilingual Resource Acquisition Adam Lopez...acquisition from bilingual data. Ma- chine Translation, 15:105–124. Peter F. Brown, John Cocke, Stephen Della Pietra, Vin- cent J. Della Pietra, Fredrick

  1. A Three-Dimensional Foil Bearing Performance Map Applied to Oil-Free Turbomachinery

    DTIC Science & Technology

    2009-04-01

    performed on the high-speed rig. The rig consists of a drive shaft in an overhung configuration supported on ceramic , hybrid ball bearings that are...Supported on Foil Air Bearings . STLE Tribology Transactions 2004, 47 (4), 508–516. 12. DellaCorte, C.; Radil, K. C.; Bruckner, R. J.; Howard, S. A...Foil Bearings -Theory and Experiments. ASME Journal of Tribology 2001, 123, 566–571. 15 14. DellaCorte, C.; Valco, M. J. Load Capacity Estimation of

  2. Tissue-Specific Regulation of Gibberellin Signaling Fine-Tunes Arabidopsis Iron-Deficiency Responses.

    PubMed

    Wild, Michael; Davière, Jean-Michel; Regnault, Thomas; Sakvarelidze-Achard, Lali; Carrera, Esther; Lopez Diaz, Isabel; Cayrel, Anne; Dubeaux, Guillaume; Vert, Grégory; Achard, Patrick

    2016-04-18

    Iron is an essential element for most living organisms. Plants acquire iron from the rhizosphere and have evolved different biochemical and developmental responses to adapt to a low-iron environment. In Arabidopsis, FIT encodes a basic helix-loop-helix transcription factor that activates the expression of iron-uptake genes in root epidermis upon iron deficiency. Here, we report that the gibberellin (GA)-signaling DELLA repressors contribute substantially in the adaptive responses to iron-deficient conditions. When iron availability decreases, DELLAs accumulate in the root meristem, thereby restraining root growth, while being progressively excluded from epidermal cells in the root differentiation zone. Such DELLA exclusion from the site of iron acquisition relieves FIT from DELLA-dependent inhibition and therefore promotes iron uptake. Consistent with this mechanism, expression of a non-GA-degradable DELLA mutant protein in root epidermis interferes with iron acquisition. Hence, spatial distribution of DELLAs in roots is essential to fine-tune the adaptive responses to iron availability.

  3. Usefulness of ileostomy defunctioning stoma after anterior resection of rectum on prevention of anastomotic leakage A retrospective analysis.

    PubMed

    Salamone, Giuseppe; Licari, Leo; Agrusa, Antonino; Romano, Giorgio; Cocorullo, Gianfranco; Falco, Nicolò; Tutino, Roberta; Gulotta, Gaspare

    2016-01-01

    Una delle principali e più temute complicanze della resezione anteriore di retto è stata ed è la deiscenza anastomotica. Solitamente, sia essa una scelta di principio od a discrezione del chirurgo operatore, viene confezionata una ileostomia laterale di sicurezza con lo scopo di prevenire tale circostanza. Scopo di tale studio è stato quello di investigare circa la utilità della stomia laterale di sicurezza quale strumento di prevenzione della deiscenza anastomotica, mettendo a paragone il decorso post-operatorio dei paziente con e senza stomia laterale. Le evidenze hanno portato alla conclusione che il confezionamento della stomia laterale di sicurezza è fattore di protezione non tanto dell’evento deiscenza anastomotica in senso stretto, quanto delle complicanze e della evoluzione clinica della stessa, vedasi ad esempio tasso di ricorrenza di deiscenza/quadro clinico in corso di deiscenza/ tempi di degenza, pur rendendosi necessario sottolineare l’assenza di significatività statistica nel tasso di mortalità nei due gruppi in studio. Cosi detto appare dunque sinottico affermare che il confezionamento di ileostomia laterale di sicurezza in corso di resezione anteriore di retto non determina una diretta azione sull’evento “deiscenza anastomotica” né “morte”, purtuttavia modifica certamente in positivo il decorso clinico ed evolutivo dell’evento “deiscenza anastomotica”.

  4. Appendix stump closure with endoloop in laparoscopic appendectomy.

    PubMed

    Caglià, Pietro; Tracia, Angelo; Spataro, Daniele; Borzì, Laura; Lucifora, Bibiana; Tracia, Luciano; Amodeo, Corrado

    2014-01-01

    L’appendicite acuta rappresenta la più comune patologia infiammatoria della cavità adddominale. Mc Burney ne ha per primo descritto il trattamento chirurgico utilizzando la classica incisione nel quadrante addominale inferiore destro. Tale approccio è stato considerato il trattamento standard della patologia appendicolare per più di un secolo, fino all’inizio dell’era video laparoscopica. I rapidi cambiamenti tecnici e gli innegabili vantaggi della procedura videolaparoscopica ha portato ad una ampia diffusione della metodica in ambito clinico. La chiusura del moncone appendicolare, durante l’appendicectomia video laparoscopica, rappresenta uno degli aspetti tecnici fondamentali della procedura per le gravi potenziali complicanze che possono derivare da un suo non appropriato trattamento. Gravi complicanze sono infatti rappresentate da deiscenza, fistole stercoracee e peritonite. La chiusura con endostapler, hem-o-look e legatura intracorporea rappresentano le metodiche più comunemente utilizzate. Tutte le alternative descritte presentano vantaggi e svantaggi e vanno rapportate ai diversi stadi clinici della patologia appendicolare. Va inoltre notato che le differenti metodiche di trattamento del moncone appendicolare non sono state testate in studi randomizzati. In base alla nostra esperienza si può affermare che il trattamento del moncone appendicolare con endoloop può essere utilizzato con sicurezza e dovrebbe essere considerata la metodica di scelta anche in relazione al rapporto costo-beneficio. Metodi alternativi di chiusura del moncone appendicolare andrebbero utilizzati in caso di appendicite flemmonosa o gangrenosa, ascesso peritiflitico e/o contemporaneo trattamento di diverticolo di Meckel.

  5. PREFACE: DICE 2012 : Spacetime Matter Quantum Mechanics - from the Planck scale to emergent phenomena

    NASA Astrophysics Data System (ADS)

    Diósi, Lajos; Elze, Hans-Thomas; Fronzoni, Leone; Halliwell, Jonathan; Prati, Enrico; Vitiello, Giuseppe; Yearsley, James

    2013-06-01

    Presented in this volume are the Invited Lectures and the Contributed Papers of the Sixth International Workshop on Decoherence, Information, Complexity and Entropy - DICE 2012, held at Castello Pasquini, Castiglioncello (Tuscany), 17-21 September 2012. These proceedings may document to the interested public and to the wider scientific community the stimulating exchange of ideas at the meeting. The number of participants has been steadily growing over the years, reflecting an increasing attraction, if not need, of such conference. Our very intention has always been to bring together leading researchers, advanced students, and renowned scholars from various areas, in order to stimulate new ideas and their exchange across the borders of specialization. In this way, the series of meetings successfully continued from the beginning with DICE 20021, followed by DICE 20042, DICE 20063, DICE 20084, and DICE 20105, Most recently, DICE 2012 brought together more than 120 participants representing more than 30 countries worldwide. It has been a great honour and inspiration to have Professor Yakir Aharonov (Tel Aviv) with us, who presented the opening Keynote Lecture 'The two-vector quantum formalism'. With the overarching theme 'Spacetime - Matter - Quantum Mechanics - from the Planck scale to emergent phenomena', the conference took place in the very pleasant and inspiring atmosphere of Castello Pasquini - in beautiful surroundings, overlooking a piece of Tuscany's coast. The 5-day program covered these major topics: Quantum Mechanics, Foundations and Quantum-Classical Border Quantum-Classical Hybrids and Many-Body Systems Spectral Geometry, Path Integrals and Experiments Quantum -/- Gravity -/- Spacetime Quantum Mechanics on all Scales? A Roundtable Discussion under the theme 'Nuovi orizzonti nella ricerca scientifica. Ci troviamo di fronte ad una rivoluzione scientifica?' formed an integral part of the program. With participation of E Del Giudice (INFN & Università di

  6. A multidisciplinary environmental integrated approach to better understand the Tegnue Reefs formation, offshore Chioggia, Northern Adriatic Sea.

    NASA Astrophysics Data System (ADS)

    Bergamasco, Andrea; Donnici, Sandra; Tosi, Luigi; Tagliapietra, Davide; Zaggia, Luca; Bonaldo, Davide; Braga, Federica; Da Lio, Cristina; Keppel, Erica; Lorenzetti, Giuliano; Manfè, Giorgia; Franceschini, Gianluca; Giovanardi, Otello; Carol, Eleonora; Fornaro, Elena; Grant, Carley

    2014-05-01

    , and benthic invertebrates like bryozoans, mollusks, serpulids and corals also contribute to the final building of the status of Tegnue's environment, but we want to demonstrate that the in first stage of consolidation abiotic phenomena could have played a major role. In order to prove our thesis a series of ground water sampling as well as rock sampling and sediment cores were carried out. The poster illustrates the overall ongoing program as well as some work in progress and first results from field cruise. Acknowledgments This work was supported by the Municipality of Chioggia through the Tegnue Project and partially by the Flagship Project RITMARE - The Italian Research for the Sea - coordinated by the Italian National Research Council and funded by the Italian Ministry of Education, University and Research within the National Research Program 2011-2013, and by the Scientific Cooperation Agreement between the CONICET (Argentina) - CNR (Italy), Program 2013-2014, Project 'Fresh-saltwaters in high-value coastlands: from the hydrogeophysical/geochemical characterization of the present interactions to the modeling quantification of the expected effects of climate changes'. References - Bonardi, M., Tosi, L. 2000. Indagini preliminari su alcune formazioni di sabbie cementate nella laguna di Venezia. In: La Ricerca Scientifica Per Venezia. Il Progetto Sistema Lagunare Veneziano, Modellistica del Sistema Lagunare Studio di Impatto Ambientale. Istituto Veneto di Scienze, Lettere ed Arti, Vol. II, Tomo II, p. 967-974, Venezia, ISBN: 88-86166-82-6. - Bonardi, M., Tosi, L., Rizzetto, F., Brancolini, G., Baradello, L. 2006. Effects of climate changes on the late Pleistocene and Holocene sediments of the Venice Lagoon, Italy. Journal of Coastal Research, SI 39, 279-284. - Casellato S., Stefanon A. 2008. Coralligenous habitat in the northern Adriatic Sea: an overview. Marine Ecology, 29: 321-341. - Gabbianelli, G., Colantoni, P., Degetto, S., Dinelli, E., Lucchini, F. 1997

  7. Specialised teams or personal continuity across inpatient and outpatient mental healthcare? Study protocol for a natural experiment

    PubMed Central

    Giacco, Domenico; Bird, Victoria Jane; McCrone, Paul; Lorant, Vincent; Nicaise, Pablo; Pfennig, Andrea; Bauer, Michael; Ruggeri, Mirella; Lasalvia, Antonio; Moskalewicz, Jacek; Welbel, Marta; Priebe, Stefan

    2015-01-01

    Introduction Mental healthcare organisation can either pursue specialisation, that is, distinct clinicians and teams for inpatient and outpatient care or personal continuity of care, that is, the same primary clinician for a patient across the two settings. Little systematic research has compared these approaches. Existing studies subject have serious methodological shortcomings. Yet, costly reorganisations of services have been carried out in different European countries, inconsistently aiming to achieve specialisation or personal continuity of care. More reliable evidence is required on whether specialisation or continuity of care is more effective and cost-effective, and whether this varies for different patient groups and contexts. Design and methods In a natural experiment, we aim to recruit at least 6000 patients consecutively admitted to inpatient psychiatric care in Belgium, Germany, Italy, Poland, and the UK. In each country, care approaches supporting specialisation and personal continuity coexist. Patients will be followed up at 1 year to compare outcomes, costs and experiences. Inclusion criteria are: 18 years of age or older; clinical diagnosis of psychosis, affective disorder or anxiety/somatisation disorder; sufficient command of the language of the host country; absence of cognitive deterioration and/or organic brain disorders; and capacity to provide informed consent. Ethics and dissemination Ethical approval was obtained in all countries: (1) England: NRES Committee North East—Newcastle & North Tyneside (ref: 14/NE/1017); (2) Belgium: Comité d'Ethique hospitalo-facultaire des Cliniques St-Luc; (3) Germany: Ethical Board, Technische Universität Dresden; (4) Italy: Comitati Etici per la sperimentazione clinica (CESC) delle provincie di Verona, Rovigo, Vicenza, Treviso, Padova; (5) Poland: Komisja Bioetyczna przy Instytucie Psychiatrii i Neurologii w Warszawie. We will disseminate the findings through scientific publications and a study

  8. Biological and clinical outcomes in the elderly with left ventricular dysfunction: Are there differences between on-pump and off-pump coronary artery bypass grafting?

    PubMed

    Concistrè, Giovanni; Dell'Aquila, Angelo Maria; Piccardo, Alessandro; Pansini, Stefano; Gargiulo, Raffaele; Gallo, Alina; Merlanti, Bruno; Passerone, Giancarlo; Regesta, Tommaso

    2015-01-01

    Il nostro studio ha lo scopo di confrontare gli eventi clinici ed i dati laboratoristici postoperatori di pazienti anziani coronaropatici con disfunzione ventricolare sinistra, sottoposti a rivascolarizzazione miocardica chirurgica eseguita con o senza ausilio della circolazione extracorporea. Studi recenti hanno evidenziato i vantaggi dell’intervento a cuore battente nei pazienti anziani, riportando una riduzione della morbidità postoperatoria e della disfunzione di organo. Tuttavia questi studi non analizzano l’impatto della disfunzione ventricolare sinistra sugli eventi postoperatori precoci e tardivi nei pazienti ad alto rischio. Abbiamo esaminato retrospettivamente 90 pazienti di età superiore ai 75 anni, con frazione di eiezione preoperatoria < 50%, sottoposti a bypass aortocoronarico, senza altre procedure cardiochirurgiche associate, tra Gennaio 2000 e Luglio 2009 presso il nostro Centro. I pazienti sono stati divisi in 2 gruppi: pazienti operati senza ausilio della circolazione extracorporea (a cuore battente) e pazienti operati con l’ausilio della circolazione extracorporea (a cuore fermo). Abbiamo confrontato I livelli sierici postoperatori degli enzimi CK, CK-MB e troponina T, indici di danno miocardico, e gli eventi cerebrovascolari. La mortalità intraospedaliera totale era del 2% (2 pazienti su 90) e simile in entrambi i gruppi (p=0.8336). I livelli medi di troponina T a 6, 24, 48 ore dopo l’intervento erano significativamente più bassi nei pazienti operati a cuore battente (p=0.0001; p=0.0021; p=0.0070). Non c’era una differenza statisticamente significativa nei 2 gruppi in termini di sopravvivenza (p=0.0764) e di eventi cerebrovascolari (p=0.3016) nell’immediato postoperatorio ed a 10 anni. I nostri risultati dunque mostrano che il non utilizzo della circolazione extracorporea nei pazienti ad alto rischio determinerebbe una più bassa incidenza di danno miocardico; tuttavia ciò sembra non influenzare a lungo termine la sopravvivenza

  9. Tension-free primary closure for the treatment of pilonidal disease.

    PubMed

    Arer, Ilker Murat; Yabanoglu, Hakan; Caliskan, Kenan

    2015-01-01

    Il sinus pilonidali (SP) è una patologia comune che colpisce in genere la popolazione giovane e localizzandosi nella regione intergflutea. Per la sua cura sono state utilizzate tecniche conservative e descritte diverse tecniche chirurgiche, queste ultime consistenti in chiusura primaria dell’escissione chirurgica, la marsupializzazione e le chiusura con flap della breccia chirurgica. Il presente studio si propone di valutare l’efficacia di un metodo chirurgico. La casistica si riferisce a 151 pazienti sottoposti a trattamento chirurgico tra Gennaio 2007 e Settembre 2014, che vengono suddivisi per età, sesso, durata dell’intervento e della degenza postoperatoria, oltre alle complicanze (deiscenze ed infezioni della ferita), recidive e domensioni pel pezzo operatorio. L’età media dei pazienti affetti da sinus pilonidalis si aggira tra i 14 ed i 66 anni (media 25,18). In 105 pazienti (69,5% del totale) si è proceduto a chiusura primaria della ferita, ed il 46 (30,5% del totale) si è adottata la tecnica tension-free. Non si sono osservate differenze statistiche tra i gruppi rispetto all’età, al sesso, alla durata dell’intervento ed a quella della degenza postoperatoria. Solo 9 pazienti operati con chiusura primaria (8,6%) e 3 pazienti (6,5%) operati con tecnica tension-free hanno presentato una recidiva postoperatoria. In 17 pazienti (7,9%) si è osservata la deiscenza della ferita, di cui 15 (14,3%) tra quelli trattati con chiusura primitive e 2 (4,3%) in quelli trattati con tecnica tension- free. Il 16 pazienti (10.6%) è stata osservata la formazione postoperatoria di sieroma o di infezione. In conclusione la tecnica tension free si dimostra metodo altrettanto efficace della chiusura primitiva.

  10. Sonographic tomography for the preoperative staging of breast cancer prior to surgery.

    PubMed

    Grady, I; Gorsuch-Rafferty, H; Hansen, P

    2010-06-01

    Sommario INTRODUZIONE: Scopo del presente lavoro è effettuare un’analisi preliminare retrospettiva di una nuova tecnica ad immagini, la TC ad ultrasuoni, utilizzata per determinare l’estensione della massa neoplastica mammaria, prima di decidere un’eventuale asportazione chirurgica. MATERIALI E METODI: Nel periodo compreso tra agosto 2007 e giugno 2008, 41 donne con diagnosi di tumore mammario hanno avuto una stadiazione della neoplasia usando la TC ad ultrasuoni. In seguito le pazienti sono state sottoposte a risonanza magnetica con mezzo di contrasto del seno per evidenziare ulteriori aree di estensione tumorale, la presenza di linfoadenopatie del cavo ascellare, di multifocalità e di bilateralità, che avrebbero potuto compromettere l’intervento chirurgico. Entrambe le tecniche sono state poi comparate per confrontarne l’accuratezza. RISULTATI: L’accuratezza della nuova tecnica, la TC ad ultrasuoni è stata del 68%, mentre quella della risonanza magnetica del 54%. L’incremento dell’accuratezza della diagnosi che ne è derivato è stato del 14% (2–28%). La TC ad ultrasuoni non appare, pertanto, inferiore alla risonanza magnetica. CONCLUSIONI: È necessario un ulteriore studio per meglio valutare la capacità e le prospettive di questa nuova tecnica nella fase pre-operatoria.

  11. Vulvar endometriosis and Nuck canal.

    PubMed

    Mazzeo, Carmelo; Gammeri, Emanuele; Foti, Agata; Rossitto, Maurizio; Cucinotta, Eugenio

    2014-12-29

    L’endometriosi è una patologia non ancora del tutto conosciuta che colpisce il 6-10% della popolazione femminile generare e il 35-50% della popolazione femminile affetta da dolore pelvico e infertilità. La sede più frequente di malattia è rappresentata dall’ovaio e ciò sostiene l’ipotesi patogenetica della mestruazione retrograda. Viene descritto un caso di non comune localizzazione vulvare di endometriosi riscontrata in una paziente precedentemente operata per una cisti di Nuck. La donna aveva notato da qualche mese l’insorgenza di una tumefazione nella regione vulvare che le causava dolore e dispareunia che si accentuavano nel periodo mestruale. Il sospetto clinico di endometriosi non aveva avuto conferma negli esami strumentali preoperatori che non avevano evidenziato alterazioni patognomoniche, nè differenze dei reperti in fase pre mestruale e mestruale. Solo l’esame istologico della neoformazione asportata ha confermato la diagnosi. Inoltre gli Autori con la presente nota desiderano sottolineare come nella patogenesi dell’endometriosi vulvare debba essere tenuta in considerazione la presenza della pervietà del dotto peritoneovaginale o dotto di Nuck. Nel caso clinico descritto, infatti, la paziente era stata sottoposta due anni prima ad asportazione di una cisti di Nuck con obliterazione del dotto peritoneovaginale. Tuttavia già in quella fase clinica poteva essersi determinato un impianto endometriosico, che si era poi evidenziato con la formazione del nodulo in sede vulvare asportato chirurgicamente.

  12. Mechanisms of signaling crosstalk between brassinosteroids and gibberellins

    PubMed Central

    Li, Qian-Feng; He, Jun-Xian

    2013-01-01

    Brassinosteroids (BRs) and Gibberellins (GAs) are two principal groups of growth-promoting phytohormones. Accumulating evidence supports that there are crosstalks between BR and GA signaling pathways. However, a molecular mechanism for direct signaling crosstalk between BRs and GAs was not revealed until recently. Works from three different groups demonstrated that an interaction between BZR1/BES1 and DELLAs, two groups of key transcriptional regulators from the BR and GA signaling pathways, respectively, mediates the direct signaling crosstalk between BRs and GAs in controlling cell elongation in Arabidopsis. It was shown that DELLA proteins not only affect the protein stability but also inhibit the transcriptional activity of BZR1. Thus, GAs promote cell elongation, at least in part, through releasing DELLA-mediated inhibition of BZR1. This review aims to introduce these recent advances in our understanding of how BRs and GAs coordinate to regulate plant growth and development at the molecular level. PMID:23603943

  13. Mechanisms of signaling crosstalk between brassinosteroids and gibberellins.

    PubMed

    Li, Qian-Feng; He, Jun-Xian

    2013-07-01

    Brassinosteroids (BRs) and Gibberellins (GAs) are two principal groups of growth-promoting phytohormones. Accumulating evidence supports that there are crosstalks between BR and GA signaling pathways. However, a molecular mechanism for direct signaling crosstalk between BRs and GAs was not revealed until recently. Works from three different groups demonstrated that an interaction between BZR1/BES1 and DELLAs, two groups of key transcriptional regulators from the BR and GA signaling pathways, respectively, mediates the direct signaling crosstalk between BRs and GAs in controlling cell elongation in Arabidopsis. It was shown that DELLA proteins not only affect the protein stability but also inhibit the transcriptional activity of BZR1. Thus, GAs promote cell elongation, at least in part, through releasing DELLA-mediated inhibition of BZR1. This review aims to introduce these recent advances in our understanding of how BRs and GAs coordinate to regulate plant growth and development at the molecular level.

  14. Can 4-port laparoscopic cholecystectomy remain the gold standard for gallbladder surgery?

    PubMed

    Kartal, Kinyas; Uludag, Mehmet

    2016-01-01

    Fin dalla prima esecuzione di una colecistectomia laparoscopica (LC), questo approccio ha attratto l’attenzione di tutti i chirurghi per continuare quindi la sua rivoluzione tecnica. Con l’aumentare dell’esperienza chirurgica si è sviluppata la tendenza verso approcci sempre meno invasivi ed ha comportato innovazioni nel campo della chirurgia laparoscopica. Le procedure chirurgiche correnti sono: l’approccio con 4 port (4PLC) che rappresenta tutt’ora il gold standard, l’approccio con 3 port (3PLC), quello con 2 port (2PLC) ed infine quello con un solo port (SPLC). La colecistectomia robotica (RC) e la chirurgia eseguita endoscopicamente tramite orifici coporei naturali (NOTES) rappresentano le altre nuove tecniche per l’esecuzione dell’asportazione della colecisti. In questo articolo ci si propone di fare un confronto obiettivo tra i diversi tipi di colecistectomia laparoscopica sulla base della corrente letteratura medica del settore.

  15. Optical lattice clocks towards the redefinition of the second

    NASA Astrophysics Data System (ADS)

    Bregolin, F.; Milani, G.; Pizzocaro, M.; Rauf, B.; Thoumany, P.; Levi, F.; Calonico, D.

    2017-05-01

    Nowadays atomic optical lattice clocks can perform frequency measurements with a fractional uncertainty at the 10-18 level in few hours of measurement, outperforming the best caesium (Cs) standards operated in the world. Since the definition of the unit of time is based on Cs, a worldwide debate about the need to promote the redefinition of the second on a optical reference is under-way. At INRIM (Istituto Nazionale di Ricerca Metrologica) we developed an optical lattice clock based on ytterbium atoms and compared it against a Cs fountain. These results are an important contribution to the debate.

  16. Hypogenic contribution to speleogenesis in a predominant epigenic karst system: A case study from the Venetian Alps, Italy

    NASA Astrophysics Data System (ADS)

    Tisato, Nicola; Sauro, Francesco; Bernasconi, Stefano M.; Bruijn, Rolf H. C.; De Waele, Jo

    2012-05-01

    Buso della Rana and Buso della Pisatela are two karstic caves located in north-east Italy. They are part of the same karst system and are developed in the Castelgomberto calcarenitic marine sediments, which were deposited in a shallow Caribbean-type sea during the Eocene. The Buso della Rana-Pisatela system developed mostly at the contact between the Castelgomberto calcarenite and underlying volcanic rocks. The system of caves is ~ 37 km long and has only three entrances, two of which are semi-artificial. The overlying karst plateau is not directly connected to the Buso della Rana-Pisatela system and, with the exception of one deep abyss, exhibits a rather poorly developed karst. This is unexpected considering the presence at depth of such a large and long cave. Gypsum (CaSO4·2H2O) has locally been observed on the walls of the Buso della Pisatela cave. Energy dispersive X-ray spectroscopy (EDS), performed with a scanning electron microscope (SEM), reveals the presence of sulfur-bearing minerals within the host rock. Gypsum was formed by oxidation of these minerals as indicated by negative δ34S values. The oxidation of sulfide minerals forms a sulfuric-acid solution that dissolves the Castelgomberto calcarenite and, once it is oversaturated in calcium, precipitates as gypsum. The lack of well-developed karst on top of the plateau and the analyses suggest that the formation mechanisms for the Buso della Rana-Pisatela system differ from classical epigenic speleogenesis. The "pyrite-effect" has been recognized in other caves and described in literature. In our case pyrite is responsible of two hypo-speleogenetic processes: i) the dissolution of a portion of the host rock and ii) the enlargement of the karst voids as a consequence of the haloclastic effect.

  17. The intraoperative use of the mini-gamma camera (MGC) in the surgical treatment of primary hyperparathyroidism: Technical reports and immediate results from the initial experience.

    PubMed

    Scerrino, Gregorio; Castorina, Serena; Melfa, Giuseppina Irene; Lo Piccolo, Clotilde; Raspanti, Cristina; Richiusa, Pierina; Costa, Renato Patrizio; Gulotta, Gaspare

    2015-01-01

    Il trattamento dell’iperparatiroidismo primario è quasi esclusivamente chirurgico e consiste nell’esplorazione sistematica delle quattro ghiandole con asportazione di quella( e) patologica(e). Le più moderne tecniche di diagnosi (ecotomografia, scintigrafia 99 mTc sestamibi), migliorando le possibilità di individuare la ghiandola responsabile della malattia, consentono l’esecuzione di tecniche miniinvasive quando vi è concordanza tra i risultati delle due tecniche, ma la sensibilità di tali indagini è inficiata dalle ectopie ghiandolari, da paratiroidi intratiroidee, da malattia multighiandolare o dalla contemporanea presenza di malattie tiroidee. Il presente studio illustra una nuova tecnica di imaging scintigrafico intraoperatorio ed indaga sulla sua possibilità di migliorare la localizzazione intraoperatoria della paratiroide patologica. A tal fine, 5 pazienti sono state sottoposte a tale metodica, tutte trattate con paratiroidectomia previa esplorazione completa delle quattro ghiandole con tecnica tradizionale, con monitoraggio intraoperatorio del paratormone. Alla tecnica convenzionale è stato aggiunto l’impiego della gamma camera intraoperatoria. Abbiamo valutato la concordanza dei risultati di tale esame con i dati dell’esplorazione chirurgica e con il dosaggio intraoperatorio del paratormone. In tutte e 5 le pazienti si è osservata una perfetta concordanza tra la localizzazione della ghiandola patologica con la scintigrafia intraoperatoria e l’esplorazione chirurgica, ed il dosaggio intraoperatorio del paratormone ha confermato i dati. Anche il follow-up ad un mese ha confermato l’eradicazione della malattia. La gamma camera intraoperatoria sembra quindi poter migliorare le possibilità di localizzazione della ghiandola responsabile dell’iperparati-roidismo primario, favorendo l’impiego di tecniche mini-invasive e migliorando i risultati dinanzi a casi “difficili”.

  18. [Nursing students' satisfaction and perception of their first clinical placement: observational study].

    PubMed

    Comparcini, Dania; Simonetti, Valentina; Tomietto, Marco; Galli, Francesco; Fiorani, Catia; Di Labio, Luisa; Cicolini, Giancarlo

    2014-01-01

    Background. Gli ambienti di apprendimento clinico sono definiti come una rete di fattori interagenti nel contesto, in grado di influenzare gli esiti dell’apprendimento degli studenti. La soddisfazione degli studenti è considerata un indicatore del raggiungimento degli esiti dell’apprendimento ed è determinante a partire dalla prima esperienza di tirocinio. Scopo. Analizzare l’esperienza di apprendimento clinico degli studenti infermieri del primo anno di corso dopo il primo tirocinio clinico ed identificare i principali determinanti della soddisfazione degli studenti. Metodo. Lo studio osservazionale è stato realizzato in cinque sedi universitarie italiane del Corso di Laurea in Infermieristica. 420 studenti hanno compilato la versione italiana della “Clinical Learning Environment, Supervision and plus Nurse Teacher (CLES+T) scale” al termine del primo tirocinio clinico. Risultati. I punteggi medi assegnati alle dimensioni della scala variano da 4.02 (clima di apprendimento) a 3.30 (relazione di tutorato). La maggior parte degli studenti è soddisfatto della propria esperienza di tirocinio (75.6%), ma sono emerse differenze in relazione alle diverse sedi di tirocinio clinico. Discussione. I principali determinanti della soddisfazione sono lo stile di leadership del coordinatore infermieristico e l’integrazione teoria-pratica nella relazione fra tutor clinico, universitario e studente. Conclusioni. I risultati dello studio contribuiscono alla comprensione della prima esperienza di tirocinio degli studenti. Tuttavia, sono necessarie ulteriori ricerche per determinare le variabili organizzative specifiche e i modelli tutoriali in grado di aumentare la soddisfazione degli studenti, per sviluppare strategie formative basate sull’integrazione tra tutor universitari e guide di tirocinio.

  19. Bio-Engineering tissue and V.A.C. therapy: A new method for the treatment of extensive necrotizing infection in the diabetic foot.

    PubMed

    Armenio, Andrea; Cutrignelli, Daniela Anna; Nardulli, Maria Luisa; Maggio, Giulio; Memeo, Giuseppe; De Santis, Valerio; Giudice, Giuseppe; Ressa, Cosmo Maurizio

    2016-12-06

    La prevalenza mondiale del diabete nel 2000 è stata stimata essere del 2.8% con una previsione del 4.4% nel 2030. A causa della neuropatia e dei processi ischemici che ne derivano, i pazienti diabetici sono purtroppo predisposti all’insorgenza di infezioni a carico del piede con un rischio di amputazione molto elevato. A tal proposito, un trattamento rapido ed efficace del processo necrotizzante impedirebbe complicanze maggiori e la stessa amputazione. Il nostro studio consiste in un’analisi retrospettiva condotta su 20 pazienti atta a valutare l’efficacia del sostituto dermico autologo bioingegnerizzato (Hyalograft 3D Autograft) in associazione alla V.A.C (vacuum assisted closure) Therapy per il trattamento delle ulcere diabetiche, rispetto ai metodi sinora impiegati. I pazienti selezionati, a seconda del trattamento eseguito, sono stati suddivisi in due gruppi omogenei di dieci pazienti ciascuno. Il gruppo controllo è stato trattato con il metodo standard, ovvero con debridment chirurgico e innesti cutanei autologhi, mentre il gruppo studio è stato trattato con il metodo in analisi. La raccolta dei dati ha suggerito come l’impiego combinato del sostituto dermico bioingegnerizzato e della pressione negativa determini, rispetto al gruppo controllo, un aumento della percentuale di guarigione, una riduzione del tasso di recidiva di lesioni anche estese e una maggiore ripresa della deambulazione autonoma. In conclusione, la nostra analisi ha evidenziato un metodo sicuro, affidabile e competitivo per il trattamento di ampie lesioni necrotizzanti del piede diabetico. Anche se ulteriori valutazioni sono necessarie, crediamo fortemente che l’associazione del derma bioingegnerizzato e della pressione negativa possa condurre ad una rapida ed efficace guarigione delle ulcere, migliorando la qualità della vita del paziente diabetico.

  20. Three-dimensional sonohysterography for examination of the uterine cavity in women with abnormal uterine bleeding: Preliminary findings.

    PubMed

    Sconfienza, L M; Lacelli, F; Caldiera, V; Perrone, N; Piscopo, F; Gandolfo, N; Serafini, G

    2010-03-01

    Sommario INTRODUZIONE: Valutare l'impatto diagnostico della Isterosonografia Tridimensionale (ISG 3D) nello studio della cavità uterina in donne con sanguinamento anomalo (SUA) rispetto all'ecografia transvaginale (ETV) e all'isterosonografia bidimensionale (ISG 2D), particolarmente per l'identificazione di neoformazioni a sviluppo endocavitario della superficie endometriale e della parete uterina. MATERIALI E METODI: Ventiquattro pazienti affette da SUA sono state incluse nello studio. Ciascuna di esse é stata sottoposta ad ETV, ISG e ISG 3D durante la medesima seduta. Le acquisizioni 3D sono state ottenute con tecnica free-hand in fase di massima replezione idrica della cavità. Tutte le pazienti sono state valutate con isteroscopia entro 10 giorni dall'ecografia. Considerando l'esame isteroscopico come reference standard, sono stati calcolati i valori di sensibilità, specificità, valore predittivo positivo (VPP), valore predittivo negativo (VPN) ed accuratezza delle tre metodiche. RISULTATI: L'isteroscopia ha dimostrato la presenza di lesioni endocavitarie in 21/24 pazienti (87,5%). Nelle restanti pazienti l'esame isteroscopico è risultato negativo. ETV, ISG 2D ed ISG 3D hanno mostrato rispettivamente sensibilità del 76% (16/21), 90% (19/21), 100% (21/21); specificità del 100% (3/3), 100% (19/19), 100% (21/21); VPP del 100%, 100%, 100%; VPN del 37%, 60%, 100%; accuratezza 76%, 90%, 100%. L'ISG 3D ha consentito una completa identificazione dei rapporti delle lesioni con la cavità uterina e con la parete endometriale. CONCLUSIONI: L'ISG 3D è una metodica con maggiore sensibilità nella definizione delle lesioni della cavità uterina rispetto all'ISG 2D ed all'ETV. Se questi dati preliminari saranno confermati da studi piú ampi, ISG 3D potrebbe essere proposta come alternativa all'isteroscopia eseguita a soli fini diagnostici.

  1. Laparoscopic surgery in pregnant patients with acute abdomen.

    PubMed

    Kocael, Pinar Cigdem; Simsek, Osman; Saribeyoglu, Kaya; Pekmezci, Salih; Goksoy, Ertugrul

    2015-01-01

    Nonostante i significativi vantaggi della chirurgia laparoscopica rispetto a quella laparotomica, essa era considerata controindicata per le donne gestanti. Attualmente si confrontano opinioni contrastanti riguardo alla sicurezza durante la gestazione della chirurgia laparoscopica, specie se nell’ultimo trimestre. Lo scopo di questo studio è quello di valutare la fattibilità della chirurgia laparoscopica in donne gestanti in caso di addome acuto analizzando retrospettivamente la casistica della pazienti ricoverate tra il gennaio 1995 ed il gennaio 2013 presso l’Emergency Department della Cerrahpasa Medical Faculty. Sono stati pertanto analizzati tutti i dati clinici riguardanti le gestanti sottoposte a chirurgia laparoscopica, comprese le cartelle cliniche, gli interventi eseguiti, i reperti anatomopatologici, e le informazioni riguardanti il parto. Nella casistica sono rientrate 14 donne gravide (in media alla 19,2° settimana di gestazione, distribuite tra 9 e 33 settimane), di cui 11 sottoposte ad appendicectomia laparoscopica, 2 a colecistectomia laparoscopica ed 1 per scopi diagnostici. In media il parto si è espletato alla 37,4° settimana di gestazione (tra la 35° e la 40° settimana). Due pazienti hanno avuto un parto prematuro, ma in nessune dei casi si sono verificate complicazioni durante le manovre laparoscopiche, e cioè danni all’utero, morti fetali o mortalità materna. Si conclude che la chirurgia laparoscopica può essere effettuata nel corso di tutti i trimestri della gravidanza, con il possibile vantaggio di una utile diagnosi differenziale in caso di dolori addominali acuti durante la gravidanza, e diminuzioni delle morti fetali dovute a ritardi diagnostici, e che tempi chirurgici più brevi riducono gli effetti negativi sulla madre e sul feto.

  2. Course of acute pancreatitis in diabetic patients.

    PubMed

    Koziel, Dorota; Gluszek, Stanislaw; Osuch, Martyna Gluszek

    2016-01-01

    Negli anni recenti in molti paesi europei si è dimostrata una crescente incidenza della pancreatite acuta (AP), ed alcuni studi indicano un aumento di rischio di AP nei pazienti diabetici. Questo studio è pertanto finalizzato a valutare il decorso clinico della AP nei pazienti diabetici. Sono stati studiati tutti i pazienti curati in reparto chirurgico per una diagnosi di AP identificando come pazienti diabetici quelli che all’anamnesi hanno confermato essere affetti da diabete di tipo 1 o di tipo 2 prima di essere ricoverati per AP. I pazienti ricoverati per AP, ed arruolati nello studio sono stati 963, e tra essi vi erano 87 (9%) diabetici. Tra questi ultimi erano più numerosi quelli portatori di calcolosi biliare quale causa della pancreatite (46% vs 32%). Nella maggioranza dei casi il decorso della AP è stato di gravità moderata, ma comunque nel 10,3% dei pazienti con diabete il decorso della malattia è stato moderatamente grave, e nel 12,7% decisamente grave. Non sono state osservate differenze nella mortalità da AP in entrambi i gruppi. Insufficienza sistemica è stata osservata più frequentemente nel gruppo dei diabetici di tipo 2 (5,4%) e 23,1% in quelli di tipo 2, a fronte del 5,1% dei pazienti non diabetici, con differenze statisticamente non significative. In conclusione l’incidenza della AP nei pazienti diabetici aumenta con l’età, ed è più spesso correlata con la calcolosi biliare. In questo gruppo di pazienti in decorso clinico è èiù frequentemente grave, con insufficienza sistemica nei diabetici di tipo 1.

  3. Europe’s Role in Nation-Building: From the Balkans to the Congo

    DTIC Science & Technology

    2008-01-01

    Ruolo della Unione Europea nella Crisi Alba- nese” [“The Role of the European Union in the Albanian Crisis”], in De Guttry and Pagani (1999). 21 Fatmir...No. 2, June 1998b, pp. 201–212. ———, “Il Ruolo della Unione Europea nella Crisi Albanese” [“The Role of the European Union in the Albanian Crisis...relations—1989– I. Dobbins, James, 1942– JZ6300E97 2008 327.1—dc22 2008016898 Left cover photo: European Union police officer Maria Donk from the

  4. To Tame a Chechen Wolf: Shedding the Failing Frame of Salafism

    DTIC Science & Technology

    2008-04-01

    Sidney Tarrow (Greenwich, CT: JAI Press, 1988), 197-217. 24. McAdam, McCarthy and Zald, 3. 25. Mona Younis, Liberation and Democratization: The South...Michigan, 1979. 49. Donatella Della Porta and Sidney Tarrow , “Transnational Processes and Social Activism: An Introduction,” in Transnational Protest...and Global Activism, edited by Donatella Della Porta and Sidney Tarrow (New York: Rowman and Littlefield, 2005), 3. 50. “Scars Remain Amid Chechen Survival,” BBC, 3 March 2007.

  5. Surgical approach for ulcerated locally advanced breast cancer. A single Center experience: a retrospective study.

    PubMed

    Laforgia, Rita; Punzo, Clelia; Panebianco, Annunziata; Volpi, Annalisa; Minafra, Marina; Sederino, Maria Grazia

    2017-01-12

    L’obiettivo del nostro studio è la valutazione della strategia chirurgica più idonea nei casi di LABC (Locally Advanced Breast Cancer) in condizioni di ulcerazione e sanguinamento. La diagnosi clinica del LABC prevede nella maggior parte dei casi una massa mammaria estesa associata ad edema, eritema, retrazione e sanguinamento, dolore, superficie cutanea irregolare e coinvolgimento linfonodale. L’intervento chirurgico di scelta per le forme T3-T4 è la mastectomia radicale che rappresenta un trattamento adeguato per il controllo locale della patologia. In caso di forme localmente avanzate e ulcerate, pur essendo forme inoperabili, l’exeresi chirurgica si rende necessaria per una bonifica locale. La presenza di fenomeni di ulcerazione e sanguinamento non rende possibile avviare un trattamento chemioterapico neoadiuvante ed è necessario eseguire interventi chirurgici palliativi. Il trattamento chirurgico stesso richiede mutilazioni ampie ed associate procedure di chirurgia plastica. Spesso per l’estensione della malattia ed il sovvertimento del corpus mammae durante l’exeresi chirurgica della mammella, la sezione su zone esenti da neoplasia non consente la chiusura immediata dei lembi. Abbiamo considerato, su un campione di 288 pazienti affette da carcinoma mammario, 11 donne con forme avanzate fra T4a e T4c (3.8%). E’ stata posta indicazione a trattamento chirurgico perché pazienti provenienti dal Pronto Soccorso con anemizzazione per neoplasie avanzate ulcerate e sanguinanti, non candidabili in prima istanza a chemioterapia neoadiuvante citoriduttiva. Le procedure adoperate per la ricostruzione della mammella sono state in 2 pazienti la rotazione di un lembo muscolo cutaneo, in 4 casi un innesto cutaneo prelevato dalla coscia, in 4 casi è stata utilizzata una matrice dermica biologica - sostituto cutaneo (INTEGRA) che è stata poi sostituita con un successivo innesto cutaneo a distanza di circa 20-30 giorni. Sono state osservate recidive in 2 casi

  6. Intrinsic Geodesy

    DTIC Science & Technology

    1952-03-01

    34), Rendiconti dell’Accademia Nazionale g, 5, 1901 33. PIZZETTI, P., Princl della teoria meccanica della figura dei pianeti ("Principles of the...G3od6sique, 18, 1928 37. SCHIGLIAK&, C., " Teoria generale del campo gravitazionale dell’ ellissoide di rotazione" ("General Theory of the Gravitational...34), Bulletin God~sigue, 14, 1949 45. MARUSSI, A., "Sulla variazione con 1’altezza dei raggi di curvatura principali nella teoria di Somigliana" ("On the

  7. Specialised teams or personal continuity across inpatient and outpatient mental healthcare? Study protocol for a natural experiment.

    PubMed

    Giacco, Domenico; Bird, Victoria Jane; McCrone, Paul; Lorant, Vincent; Nicaise, Pablo; Pfennig, Andrea; Bauer, Michael; Ruggeri, Mirella; Lasalvia, Antonio; Moskalewicz, Jacek; Welbel, Marta; Priebe, Stefan

    2015-11-25

    Mental healthcare organisation can either pursue specialisation, that is, distinct clinicians and teams for inpatient and outpatient care or personal continuity of care, that is, the same primary clinician for a patient across the two settings. Little systematic research has compared these approaches. Existing studies subject have serious methodological shortcomings. Yet, costly reorganisations of services have been carried out in different European countries, inconsistently aiming to achieve specialisation or personal continuity of care. More reliable evidence is required on whether specialisation or continuity of care is more effective and cost-effective, and whether this varies for different patient groups and contexts. In a natural experiment, we aim to recruit at least 6000 patients consecutively admitted to inpatient psychiatric care in Belgium, Germany, Italy, Poland, and the UK. In each country, care approaches supporting specialisation and personal continuity coexist. Patients will be followed up at 1 year to compare outcomes, costs and experiences. Inclusion criteria are: 18 years of age or older; clinical diagnosis of psychosis, affective disorder or anxiety/somatisation disorder; sufficient command of the language of the host country; absence of cognitive deterioration and/or organic brain disorders; and capacity to provide informed consent. Ethical approval was obtained in all countries: (1) England: NRES Committee North East-Newcastle & North Tyneside (ref: 14/NE/1017); (2) Belgium: Comité d'Ethique hospitalo-facultaire des Cliniques St-Luc; (3) Germany: Ethical Board, Technische Universität Dresden; (4) Italy: Comitati Etici per la sperimentazione clinica (CESC) delle provincie di Verona, Rovigo, Vicenza, Treviso, Padova; (5) Poland: Komisja Bioetyczna przy Instytucie Psychiatrii i Neurologii w Warszawie. We will disseminate the findings through scientific publications and a study-specific website. At the end of the study, we will develop

  8. The first Italian Superconducting Fault Current Limiter: Results of the field testing experience after one year operation

    NASA Astrophysics Data System (ADS)

    Martini, L.; Bocchi, M.; Ascade, M.; Valzasina, A.; Rossi, V.; Ravetta, C.; Angeli, G.

    2014-05-01

    Ricerca sul Sistema Energetico S.p.A. (RSE) has been gaining a relevant experience in the simulation, design and installation of resistive-type Superconducting Fault Current Limiter (SFCL) devices for more than five years in the framework of a R&D national project funded by the Ricerca di Sistema (RdS). The most recent outcome of this research activity is the installation of a resistive-type BSCCO-based 9 kV / 3.4 MVA SFCL device in a single feeder branch of the Medium Voltage (MV) distribution network managed by A2A Reti Elettriche S.p.A (A2A) in the Milano area. This installation represents the first SFCL successfully installed in Italy. In this paper, we report on the main outcomes after a more than 1-year long steady-state field testing activity. The design of an upgraded device to be installed in the same substation has already been initiated: the new SFCL will allow to protect four different feeders, therefore implying a device upgrade up to 15.6 MVA.

  9. Preoperative localization of distal colorectal tumours.

    PubMed

    Bayrak, Savas; Kinaci, Erdem; Ozakay, Abdulkerim; Bektas, Ceyda Turan; Yardimci, Aytul Hande; Arslan, Esra; Sevinc, Mert Mahsuni; Bektas, Hasan

    2016-01-01

    L’identificazione della reale sede del tutmore è essenziale per la formulazione di un adatto algoritmo nei cancri localizzati distalmente nel colon-retto (CTC). In questo studio è stata indagata l’efficacia della localizzazione di tumori distali del colon-retto di quattro metodologia: la colonscopia, la TAC, l’imaging della RMN, e la PET con fluoro-18-desossi-glicosio tomografia computerizzata (CT), analizzando retrospettivamente le cartelle cliniche di 156 pazienti affetti, Fluorodeoxyglucose -positron emission tomography scan da tumore del colon-sigma, della giunzione retto sigmoidea e del retto sottoposti a trattamento chirurgico. Per quanto riguarda l’accuratezza delle quattro metodologie essa è risultata simile: 74% per la clolonscopia, 67% per la TAC, 75% per la RMN e 74% con la PET. La colonscopia è risultata meno sensibile nei tumori retto-sigmoidei (33%) mentre la TAC è risultata meno sensibile (26%) e la RMN meno specifica (33%) per i tumori del retto. In conclusione, confermando l’importanza di poter localizzare correttamente i tumori distali del colon retto al fine di determinare le strategia più accurate del trattamento, le indagini preoperatorie non forniscono dati di adeguata accuratezza per i tumori colon rettali distali, e solo l’uso combinato di esse può accrescere il risultato cercato.

  10. 21 CFR Appendix B to Subpart A of... - List of Authorities

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Control Farmacéutico. For medicinal products for veterinary use: Ministerio de Agricultura, Pesca y...: Agence du Médicament. For veterinary medicinal products: Agence Nationale du Médicament Vétérinaire..., Dipartimento Farmaci e Farmacovigilanza. For medicinal products for veterinary use: Ministero della...

  11. Castelli, Benedetto (1578-1643)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Mathematician, born in Brescia, Italy, Benedictine monk, professor at Padua. GALILEO's closest scientific collaborator, he defended, and edited Galileo, he helped his sunspot research, inventing the method of projection so as to view safely the Sun's image with a telescope. His book on hydraulics, Della Misura dell'Acque Correnti, or On the Measurement of Running Waters, founded modern hydrodynam...

  12. Metric Selection for Evaluation of Human Supervisory Control Systems

    DTIC Science & Technology

    2009-12-01

    Conceptual model of human-supervisory control (modified from Pina , Cummings et al. (2008...42  4 LIST OF TABLES Table 1. Human supervisory control metric classes ( Pina , Donmez...literature in terms of human- autonomous vehicle interaction (Crandall & Cummings, 2007; Olsen & Goodrich, 2003; Pina , Cummings, Crandall, & Della Penna

  13. Nespoli conducts ham radio session in the SM

    NASA Image and Video Library

    2011-01-08

    ISS026-E-016991 (8 Jan. 2011) --- European Space Agency astronaut Paolo Nespoli, Expedition 26 flight engineer, conducts a ham radio session from the Zvezda Service Module of the International Space Station with students at Universit? degli studi di Bari ?Cittadella Mediterranea della Scienza,? Bari, Italy.

  14. Slanting Design: A Pilot Program

    DTIC Science & Technology

    1985-10-01

    adequate financing and proper planning and forethought. itG’ven the significant number of variables over which FEMA has no control , however, it would...Eskilstuna SWEDEN Ministero dell Interno Direzione Generale della Protezione Civile 00100 Rome ITALY Directeur de la Protection: Civile Ministere de

  15. Interdisciplinary Co-operation (Part II of "Language Learning: Individual Needs, Interdisciplinary Co-operation, Bi- and Multilingualism").

    ERIC Educational Resources Information Center

    1978

    The following papers on interdisciplinary cooperation in second language instruction are included: (1) "Language Teaching: Possibilities for Interdisciplinary Co-operation," by James E. Alatis; (2) "L'insegnamento della letteratura italiana (The Teaching of Italian Literature)," by Ezio Raimondi; (3) "Objective Evaluation and Transparency," by…

  16. Significance of Metacognitive Variables on Officer Selection

    DTIC Science & Technology

    2000-08-01

    the more or less deliberate AA.VV., "La funzione metacognitiva in attempt to modify one’s responses so as to create a psicoterapia : Scala di...Valutazione della hypothetical image of equilibrium and Metacognizione (S.Va.M.)", Psicoterapia , 9, pp. psychological well-being. 91-107, 1997. BATTISTELLI

  17. Course on Normalization

    DTIC Science & Technology

    1989-07-17

    natural deductions in a type theory with realizing terms. In V. Michele Abrusci and Ettore Casari, editors, Atti del Congresso Logica e Filosofia ...theory with realizing terms In Ait del Congresso Logica e Filosofia della Scienza, oggi. San Gimignano, 7-11 dicembre 1983. Voll-Logica. CLUEB, Bologna

  18. An Imaginative Approach to Teaching Writing

    ERIC Educational Resources Information Center

    Cuenca, Carmen Manuel; Carmona, Rodrigo Fernandez

    2012-01-01

    Mindful of the fact that one of the most important ingredients in learning to write in a foreign language is motivation, the authors have experimented in their classes with a wide range of exercises from a very useful source: Gianni Rodari's "Grammatico della Fantasia: lntroduzione all'arte di inventare storie" (Torino: Piccola Biblioteca Einandi,…

  19. The Urban Complex in Cattolica, Italy.

    ERIC Educational Resources Information Center

    PEB Exchange, 2003

    2003-01-01

    The Italian city of Cattolica has developed an urban complex, the Piazza della Repubblica, that offers a wide range of public services. In renovated facilities it provides a modern architectural setting based on the idea of a traditional town square. It houses a primary school, cultural center (including a library), and theater, and it is an…

  20. The non-gibberellic acid-responsive semi-dwarfing gene uzu affects Fusarium crown rot resistance in barley.

    PubMed

    Chen, Guangdeng; Yan, Wei; Liu, Yaxi; Wei, Yuming; Zhou, Meixue; Zheng, You-Liang; Manners, John M; Liu, Chunji

    2014-01-13

    Studies in Arabidopsis show that DELLA genes may differentially affect responses to biotrophic and necrophic pathogens. A recent report based on the study of DELLA-producing reduced height (Rht) genes in wheat and barley also hypothesized that DELLA genes likely increased susceptibility to necrotrophs but increased resistance to biotrophs. Effects of uzu, a non-GA (gibberellic acid)-responsive semi-dwarfing gene, on Fusarium crown rot (FCR) resistance in barley were investigated. Fifteen pairs of near isogenic lines for this gene were generated and assessed under two different temperature regimes. Similar to its impacts on plant height, the semi-dwarfing gene uzu also showed larger effects on FCR severity in the high temperature regime when compared with that in the low temperature regime. Results from this study add to the growing evidence showing that the effects of plant height on Fusarium resistances are unlikely related to DELLA genes but due to direct or indirect effects of height difference per se. The interaction between these two characteristics highlights the importance of understanding relationships between resistance and other traits of agronomic importance as the value of a resistance gene could be compromised if it dramatically affects plant development and morphology.

  1. Clinical competence in nursing: A concept analysis.

    PubMed

    Notarnicola, Ippolito; Petrucci, Cristina; De Jesus Barbosa, Maria Rosimar; Giorgi, Fabio; Stievano, Alessandro; Lancia, Loreto

    2016-01-01

    Introduzione. In campo infermieristico la ‘competenza clinica’ è una questione centrale per l’assistenza al paziente e è fondamentale una chiara comprensione del concetto sia per la formazione che per la disciplina infermieristiche. Scopo. Effettuare un analisi del concetto di ‘competenza clinica’ in campo infermieristico. Metodo: E’ stato utilizzato il metodo descritto da Walker e Avant. È stata effettuata una revisione sistematica della letteratura su database internazionali ( PubMed, CINAHL, Scopus, Cochrane, Ovid, Open Grey ) dal 1993 al 2015. Negli articoli reperiti è stata esaminata l’utilizzazione del concetto in esame. Risultati. Sono stati descritti tutti gli 8 step previsti dal modello di Walker e Avant sulla base dei risultati della revisione sistematica della letteratura. Sono stati identificati e discussi gli attributi, gli antecedenti, le conseguenze e i riferimenti empirici della competenza clinica in campo infermieristico e sono stati costruiti i casi modello, limite e contrario. E’ stata discussa anche la rilevanza del concetto sia per la formazione che per lo sviluppo professionale in campo infermieristico. Conclusioni. Questa analisi di concetto ha portato a definire la ‘competenza clinica’ in campo infermieristico come ‘un insieme di capacità, conoscenze, attitudini e abilità che ciascun infermiere deve possedere per effettuare in maniera accettabile tutte quelle attività direttamente correlate all’assistenza al paziente, in uno specifico contesto clinico e in specifiche circostanze allo scopo di promuovere, mantenere e ristabilire la salute dei pazienti’.

  2. Romans 12 Motivational Gifts and College Professors: Implications for Job Satisfaction and Person-Job Fit

    ERIC Educational Resources Information Center

    Tomlinson, Jon C.; Winston, Bruce E.

    2011-01-01

    This study builds on earlier work by DellaVecchio and Winston (2004) and McPherson (2008). They addressed the seven motivational gifts Paul wrote about in Romans 12:3-8 as a means for addressing job satisfaction and person-job fit among college professors. Using a snowball sampling method, 89 college professors completed the online survey…

  3. Mutations in the F-box gene SNEEZY result in decreased arabidopsis GA signaling

    USDA-ARS?s Scientific Manuscript database

    We previously reported that the SLEEPY1 (SLY1) homolog, F-box gene SNEEZY/SLEEPY2 (SNE/SLY2), can partly replace SLY1 in gibberellin (GA) hormone signaling through interaction with DELLAs RGA and GAI. To determine whether SNE normally functions in GA signaling, we characterized the phenotypes of tw...

  4. Allocation of Attention and Effect of Practice on Persons with and without Mental Retardation

    ERIC Educational Resources Information Center

    Oka, Kohei; Miura, Toshiaki

    2008-01-01

    Persons with mild and moderate mental retardation and CA-matched persons without mental retardation performed a dual-task, "pencil-and-paper task" (Baddeley, Della Sala, Gray, Papagno, & Spinnler (1997). Testing central executive functioning with a pencil-and-paper test. In Rabbit (Ed.), Methodology of Frontal and Executive Function (pp. 61-80).…

  5. The Emergence of For-Profit E-learning Providers in Asia

    ERIC Educational Resources Information Center

    Perkins, Ross

    2009-01-01

    This article presents an interview with Dr. Luca Botturi, winner of the 2008 Educational Communication and Technology (ECT) Foundation Robert deKeiffer International Fellowship Award. Dr. Botturi, an Italian originally from the suburbs of Milano, works at the Universita della Svizzera italiana (USI, also called the University of Lugano) in its New…

  6. Invitation to Lifelong Learning.

    ERIC Educational Resources Information Center

    Gross, Ronald, Ed.

    In this anthology of readings, 28 scholars and educators consider the theoretical and practical forces that shape the concept of lifelong learning. After Ronald Gross's introduction, the first section begins its consideration of the Western tradition in adult learning with Plato's metaphor of the cave and includes Pico della Mirandola's essay on…

  7. The Emergence of For-Profit E-learning Providers in Asia

    ERIC Educational Resources Information Center

    Perkins, Ross

    2009-01-01

    This article presents an interview with Dr. Luca Botturi, winner of the 2008 Educational Communication and Technology (ECT) Foundation Robert deKeiffer International Fellowship Award. Dr. Botturi, an Italian originally from the suburbs of Milano, works at the Universita della Svizzera italiana (USI, also called the University of Lugano) in its New…

  8. Motivating the Notion of Generic Design within Information Processing Theory: the Design Problem Space

    DTIC Science & Technology

    1988-12-09

    company or a social welfare policy for a state. On this account, anyone dissatisfied with existing states of affairs and attempting to transform them into...Norman Cliff Dipartimento di Psicologia Department of Psychology Via della Pergola 48 Univ. of So. California 50121 Firenze Los Angeles, CA 90089-1061

  9. Invitation to Lifelong Learning.

    ERIC Educational Resources Information Center

    Gross, Ronald, Ed.

    In this anthology of readings, 28 scholars and educators consider the theoretical and practical forces that shape the concept of lifelong learning. After Ronald Gross's introduction, the first section begins its consideration of the Western tradition in adult learning with Plato's metaphor of the cave and includes Pico della Mirandola's essay on…

  10. Multidisciplinary approach to follicular thyroid carcinoma with giant mandibular and multiple sites metastases Case report.

    PubMed

    De Pasquale, Loredana; Rabbiosi, Dimitri; Bardazzi, Alessandro; Autelitano, Luca; Moro, Giacomina Pierina; Ghilardi, Giorgio

    2014-01-01

    I tumori metastatici in genere hanno una cattiva prognosi, con sopravvivenza breve e raramente sono candidabili al trattamento chirurgico. Nel caso dei carcinomi differenziati della tiroide, la prognosi è solitamente migliore, grazie alla possibilità di un approcio multidisciplinare e soprattutto al trattamento radiometabolico dei secodarismi, dopo l’asportazione del tumore primitivo. Il caso presentato riguarda una donna di 65 anni, che è giunta alla nostra osservazione per una tumefazione mandibolare, risultata successivamente una metastasi da carcinoma follicolare della tiroide, a partenza da un voluminoso gozzo cervico-mediastinico normofunzionante, con ulteriori secondarismi a livello polmonare. Dopo un accurato studio pre-operatorio la Paziente è stata sottoposta a resezione della mandibola sinistra con ricostruzione mediante una protesi metallica e a tiroidectomia totale. Successivamente è stata trattata con quattro cicli di terapia radiometabolica con buona risposta. La Paziente è viva, senza ulteriore progressione di malattia a un follow-up di quarantasei mesi. Anche nei casi di tumori differnziati della tiroide in fase metastatica, l’opzione chirurgica va presa in considerazione per consentire alle terapie complementari di migliorare la prognosi in termini di sopravvivenza.

  11. Autologous bone grafting with platelet-rich plasma for alveolar cleft repair in patient with cleft and palate.

    PubMed

    Giudice, Giuseppe; Cutrignelli, Daniela Anna; Leuzzi, Sara; Robusto, Fabio; Sportelli, Pasquale; Nacchiero, Eleonora

    2016-01-01

    L’innesto osseo è essenziale nella terapia chirurgica della labiopalatoschisi (LPS), ma i tempi di osteogenesi ed integrazione ossea nella sede ricevente possono procrastinare i successivi interventi di ortodonzia. Nel nostro studio è stata valutata la capacità della PRP (platelet-rich plasma) associata al trapianto osseo nel diminuire il tempo d’attesa e la durata del trattamento ortodontico in una coorte di 8 bambini, confrontandola con 8 controlli sottoposti a semplice innesto osseo. I risultati hanno mostrato come i soggetti sottoposti a trapianto osseo + PRP abbiano avuto la possibilità di essere sottoposti ad un trattamento ortodontico più precoce (155 giorni vs 298) e più breve (295 giorni vs 356) rispetto al gruppo di controllo. Inoltre nel gruppo di controllo si sono verificate con maggiore frequenza complicanze post-chirurgiche (quali fistole oro-nasali, disturbi periodontali, malattie dentali, perdita di spessore, massa o trabecolatura ossea) rispetto al gruppo sottoposto a PRP. Perciò l’associazione della PRP (platelet-rich plasma) al trapianto osseo è una metodica che sembra associarsi ad una diminuzione statisticamente significativa dei tempi di integrazione ossea nei pazienti affetti da LPS, con conseguente anticipazione della ortodonzia e miglioramento degli outcome chirurgici.

  12. The Urban Complex in Cattolica, Italy.

    ERIC Educational Resources Information Center

    PEB Exchange, 2003

    2003-01-01

    The Italian city of Cattolica has developed an urban complex, the Piazza della Repubblica, that offers a wide range of public services. In renovated facilities it provides a modern architectural setting based on the idea of a traditional town square. It houses a primary school, cultural center (including a library), and theater, and it is an…

  13. OSIRIS-REx Mission Science Briefing

    NASA Image and Video Library

    2016-09-06

    In the Kennedy Space Center’s Press Site auditorium, Daniella DellaGiustina, OSIRIS-REx lead image processing scientist at the University of Arizona, Tucson, speaks to members of the media during a briefing on science experiments involved in NASA’s Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer, or OSIRIS-REx spacecraft.

  14. Genetic Characterization and Functional Analysis of the GID1 Gibberellin Receptors in Arabidopsis[W

    PubMed Central

    Griffiths, Jayne; Murase, Kohji; Rieu, Ivo; Zentella, Rodolfo; Zhang, Zhong-Lin; Powers, Stephen J.; Gong, Fan; Phillips, Andrew L.; Hedden, Peter; Sun, Tai-ping; Thomas, Stephen G.

    2006-01-01

    We investigated the physiological function of three Arabidopsis thaliana homologs of the gibberellin (GA) receptor GIBBERELLIN-INSENSITIVE DWARF1 (GID1) by determining the developmental consequences of GID1 inactivation in insertion mutants. Although single mutants developed normally, gid1a gid1c and gid1a gid1b displayed reduced stem height and lower male fertility, respectively, indicating some functional specificity. The triple mutant displayed a dwarf phenotype more severe than that of the extreme GA-deficient mutant ga1-3. Flower formation occurred in long days but was delayed, with severe defects in floral organ development. The triple mutant did not respond to applied GA. All three GID1 homologs were expressed in most tissues throughout development but differed in expression level. GA treatment reduced transcript abundance for all three GID1 genes, suggesting feedback regulation. The DELLA protein REPRESSOR OF ga1-3 (RGA) accumulated in the triple mutant, whose phenotype could be partially rescued by loss of RGA function. Yeast two-hybrid and in vitro pull-down assays confirmed that GA enhances the interaction between GID1 and DELLA proteins. In addition, the N-terminal sequence containing the DELLA domain is necessary for GID1 binding. Furthermore, yeast three-hybrid assays showed that the GA-GID1 complex promotes the interaction between RGA and the F-box protein SLY1, a component of the SCFSLY1 E3 ubiquitin ligase that targets the DELLA protein for degradation. PMID:17194763

  15. Barotropic Tides in the Bab el Mandab Strait -- Numerical Simulations

    DTIC Science & Technology

    2005-01-01

    Sciences, Dept. of Fisheries and Oceans, Ottawa, Canada. Vercelli, F., 1925. Richerche di oceanografia fisica eseguite della Jarosz, E., 2002. Tidal...Annali Idrografici 11, 1-188. Louisiana. Vercelli, F., 1927. Richerche di oceanografia fisica eseguite Kolar, R.L., Gray, W.G., Westerink, J.J

  16. Interdisciplinary Co-operation (Part II of "Language Learning: Individual Needs, Interdisciplinary Co-operation, Bi- and Multilingualism").

    ERIC Educational Resources Information Center

    1978

    The following papers on interdisciplinary cooperation in second language instruction are included: (1) "Language Teaching: Possibilities for Interdisciplinary Co-operation," by James E. Alatis; (2) "L'insegnamento della letteratura italiana (The Teaching of Italian Literature)," by Ezio Raimondi; (3) "Objective Evaluation and Transparency," by…

  17. A primary subcutaneous hydatid cyst in the thigh A case report.

    PubMed

    Salamone, Giuseppe; Licari, Leo; Randisi, Brenda; Di Carlo, Paola; Tutino, Roberta; Falco, Nicolò; Augello, Giuseppe; Raspanti, Cristina; Cocorullo, Gianfranco; Gulotta, Gaspare

    2016-04-08

    L’Echinococcus spp. rappresenta il movente eziopatogenetico della malattia idatidea, patologia a carattere endemico in diverse parti del mondo, con tipica localizzazione della cisti da echinococco, prodotto del ciclo vitale del parassita, in sede polmonare od epatica. Ciononostante le localizzazioni atipiche della malattia esistono e rappresentano circa il 1,6% dei casi, la più comune delle quali certamente quella sottocutanea. I dati a disposizione circa la diagnosi ed il trattamento delle rare forme a localizzazione atipica risultano disomogenei e pochi dirimenti circa uno standard diagnostico-terapeutico da adottare. Si è voluto presentare dunque il caso di una donna di 68 anni che lamentava la comparsa di una tumefazione al terzo prossimale della coscia dx che tendeva ad incrementarsi volumetricamente nel tempo. Dopo diverse indagini cliniche, oltre che una accurata anamnesi, il sospetto di cisti idatidea è stato confermato. La patologia è stata trattata secondo uno schema terapeutico chirurgico e farmacologico ben dettagliato. La raccolta di questi dati si prefigge lo scopo di pianificare, in accordo con la letteratura scientifica e la review dei case-report esistenti, linee guida nel percorso assistenziale di questa rara manifestazione di una comune malattia.

  18. Prospective evaluation of interobserver diagnostic agreement for focal urinary bladder wall abnormalities detected by ultrasound.

    PubMed

    Francica, G; Scarano, F; Bellini, S A; Miragliuolo, A

    2011-03-01

    Sommario INTRODUZIONE: È stata valutata prospetticamente la variabilità interosservatore relativamente alla diagnosi di alterazioni focali della parete vescicale tra due operatori con diverso livello di esperienza. MATERIALI E METODI: Due operatori con diverso livello di esperienza in ecografia hanno esaminato indipendentemente nella stessa sessione 87 pazienti consecutivi (età media 68 anni; range 33–80; 75 maschi; 15 donne) sottoposti successivamente a cistoscopia entro 1–2 giorni. Prima dell’inizio dello studio la metodologia di studio è stata standardizzata. Il grado di accordo sulla presenza, sede, dimensioni e numero delle alterazioni parietali della vescica è stato calcolato con il metodo della Kw. RISULTATI: Il grado più elevato di accordo (k = 1) è stato raggiunto relativamente alla presenza delle alterazioni parietali, mentre un accordo sostanziale è stato ottenuto per le dimensioni (k = 0.78), numero (k = 0.72) e sede (k = 0.62). CONCLUSIONI: In questo studio la differenza di esperienza tra due operatori non è emersa nella diagnostica delle alterazioni parietali della vescica anche in ragione di una metodologia standardizzata di studio.

  19. Databases for Assessment of Military Speech Technology Equipment. (les Bases de donnees pour l’evatuation des equipements de technologie vocale militaire)

    DTIC Science & Technology

    2000-03-01

    documentazione ROYAUME-UNI Carretera de Torrej6n a Ajalvir, Pk.4 tecnico-scientifica della Difesa Defence Research Information Centre 28850 Torrej6n de Ardoz...Aviation Carretera de Torrej6n a Ajalvir, Pk.4 obrann6ho v2zkumu (NISCR) c/o Flugrad 28850 Torrej6n de Ardoz - Madrid Mladoboleslavsk. ul., 197 06

  20. Program Derivation by Proof Transformation

    DTIC Science & Technology

    1993-10-01

    L6f’s theory of types. 178 REFERENCES In Atti Degli Incontri di Logica Mathematica, pages 299-325. Dipartimento di Matematica , Universiti di Siena, 1982...Congresso Logica e Filosfia della Scienza. oggi. San Gimignano, December 7-11, 1983, pages 95-138, Bologna, Italy, 1985. CLUEB. [Smi9l] Douglas R

  1. Oceanographic Research Towers in European Waters

    DTIC Science & Technology

    1992-12-01

    16m Administration, Persons or Contact, and Access Administration * Istituto (formerly Laboratorio) per lo Studio della Dinamica delle Grandi Masse...also written Istituto Studio Dinamica Grandi Masse (ISDGM)], San Polo 1364, 1-30125 Venezia, Italy Persons of Contact Director of the Institute * Dr

  2. Allocation of Attention and Effect of Practice on Persons with and without Mental Retardation

    ERIC Educational Resources Information Center

    Oka, Kohei; Miura, Toshiaki

    2008-01-01

    Persons with mild and moderate mental retardation and CA-matched persons without mental retardation performed a dual-task, "pencil-and-paper task" (Baddeley, Della Sala, Gray, Papagno, & Spinnler (1997). Testing central executive functioning with a pencil-and-paper test. In Rabbit (Ed.), Methodology of Frontal and Executive Function (pp. 61-80).…

  3. Laparoscopic adrenalectomy in a case of congenital duplication of the inferior vena cava. Case report.

    PubMed

    Pisano, Giuseppe; Calò, Pietro Giorgio; Piras, Stefano; Pisano, Umberto; Nicolosi, Angelo

    2013-07-25

    L’eventualità di un’emorragia intraoperatoria è la complicanza più temuta nel corso di una surrenectomia laparoscopica. Tale rischio diventa ancora più importante nel caso in cui siano presenti anomalie anatomiche rappresentate da duplicità della Vena Cava Inferiore (VCI) e da anomali confluenze delle vene surrenali. Tale riscontro, osservato nel caso descritto, ha fornito lo spunto per uno studio sull’incidenza di dette anomalie e sulle metodiche utili a prevenire la complicanza emorragica. Una donna di 39 anni è giunta alla nostra osservazione a causa di una neoformazione non funzionante del surrene destro andata incontro ad un lento ma progressivo accrescimento volumetrico. Tale neoformazione era stata riconosciuta a distanza di tempo nel corso di controlli clinici e strumentali praticati per una Poliposi Familiare del Colon, sottoposta in altra sede a Proctocolectomia Restorativa circa 8 anni prima. Già in quell’epoca era stata documentata una duplicità congenita della VCI associata ad altre anomalie vascolari e viscerali. Nel corso della surrenectomia laparoscopica, dopo aver clippato e sezionato la vena surrenalica alla sua confluenza cavale, è stata riconosciuta una seconda vena con sbocco nella vena renale destra; anch’essa trattata in modo analogo e con esito favorevole. La presenza di una duplice VCI, pur essendo un reperto piuttosto raro, è divenuta di più frequente riscontro con la diffusione di tecniche di diagnostica per immagini sempre più elaborate, in particolare l’AngioTC. La presenza di tali anomalie può rendere problematiche alcune manovre di radiologia interventistica quali il posizionamento di un filtro cavale o il cateterismo selettivo di una vena surrenalica. È però in ambito chirurgico che la duplicità della VCI può causare i maggiori inconvenienti, rappresentati da un possibile danno vascolare. La maggior parte degli Autori ritiene in proposito indispensabile un valido studio per immagini preoperatorio quale

  4. Influence of fear of movement on total knee arthroplasty outcome.

    PubMed

    Kocic, Mirjana; Stankovic, Anita; Lazovic, Milica; Dimitrijevic, Lidija; Stankovic, Ivona; Spalevic, Marija; Stojiljkovic, Predrag; Milenkovic, Marina; Stojanovic, Zorica; Nikolic, Dejan

    2015-01-01

    RiassuntoLo scopo dello studio è quello di verificare l’incidenza del timore postoperatorio ai movimenti nei pazienti sottoposti ad artroplastica totale del ginocchio (TKA) e di determinare l’associazione di questo timore con i provvedimenti da adottare. Lo studio prospettico riguarda 78 pazienti sottoposti ad TKA primaria per osteoartrite. L’incidenza di timore al movimento è stata detenninata con l’uso della Tampa Scale of Kinesiophobia (TSK). I pazienti sono stati valutati in tre fasi temporali: 2 settimane. 4 settimane e 6 mesi dopo l’intervento chirurgico. In tutte e tre le fasi sono stati valutati il dolore e l’entità della flessione, mentre l’aspetto funzionale è stato preso in considerazione soltanto sei mesi dopo l’intervento, secondo la Oxford knee score 1. Il timore al movimento è stato registrato in 17 pazienti (21,8%). Quelli con maggiore entità di timore hanno dimostrato di conseguire risultati significativamente meno buoni in termini di dolore, grado di flessione e funzionalità rispetto a quelli con limitata paura. Miglioramento del dolore e della flessione sono stati progressivamente conseguiti nel tempo in entrambi i gruppi, ma i risultati migliori vengono raggiunti nel gruppo con minore paura al movimento. Lo studio ha dimostrato che la paura postoperatoria alla motilità si associa significativamente con il dolore, l’entità della flessione e la funzionalità del ginocchio. Altri Autori haImo rilevato che il timore preoperatorio alla motilità del ginocchio fa prevedere limitazioni funzionali postoperatorie. In conclusione il timore della motilità si rileva in una significativa proporzione dei pazienti dopo TKA e si associa con gonalgia, e minore flessione e funzionalità, e dunaue questa paura rappresenta un richio di scarsi risultati dopo artroplastica totale del ginocchio.

  5. Laparoscopic and ultrasound assisted management of gallstone ileus after biliointestinal bypass Case report and a review of literature.

    PubMed

    Zago, Mauro; Bozzo, Samantha; Centurelli, Andrea; Giovanelli, Alessandro; Vasino, Michele Ciocca

    2016-05-24

    L’ileo biliare (IB) è una rara urgenza chirurgica, secondaria alla formazione di una fistola colecisto-enterica. È una patologia ancora gravata da una elevata mortalità (15-18%), soprattutto perchè prevalente nella popolazione anziana. L’IB si manifesta con i sintomi aspecifici dell’occlusione intestinale (dolore e distensione addominale, alvo chiuso a feci e gas, vomito) e, per tale ragione, la diagnosi eziologica preoperatoria non è frequente. La triade radiologica di Rigler (pneumobilia, presenza di un calcolo ectopico, livelli idro-aerei) è patognomonica, ma identificabile solo in circa il 15% dei casi alla radiografia dell’addome. A motivo della rarità della patologia, non vi è unanime consenso circa il trattamento dell’IB. In letteratura sono pochi i lavori che riportano l’insorgenza di IB in pazienti precedentemente sottoposti a chirurgia bariatrica. La revisione della letteratura ha permesso di reperire tre casi di ileo biliare successivi a chirurgia bariatrica, di cui due conseguenti a bypass biliodigestivo. Viene presentato un ulteriore caso di una paziente di 41 anni che ha sviluppato un ileo biliare otto anni dopo un intervento bariatrico di bypass bilio-intestinale laparoscopico. Nei pazienti sottoposti a intervento di bypass bilio-digestivo per obesità patologica, viene confezionata una anastomosi tra la colecisti ed il digiuno in modo da conservare la circolazione enteropatica, riducendo le conseguenze del malassorbimento. L’analisi della letteratura relativa ai casi di ileo biliare post-bariatrici pubblicati e di quella più generale sull’ileo biliare, permette di elaborare considerazioni di pratica utilità inerenti la diagnosi pre-operatoria, il ruolo dell’ecografia nella pianificazione della strategia chirurgica e il trattamento chirurgico laparoscopico a cui è stata sottoposta la paziente.

  6. The pedagogic evolution in Surgery: the University at the centre of a training which becomes territorialized The model of the region Marche.

    PubMed

    Patrizi, Andrea; Tranà, Cristian; Baldoni, Andrea; Coletta, Pietro; Marmorale, Cristina

    2014-01-01

    La formazione in Chirurgia è un tema di grande interesse in un’epoca di crisi, ma anche di grandi cambiamenti mossi dalla spinta della Comunità Europea di uniformare i Percorsi Formativi di tutti i suoi Stati Membri. I punti principali delle riforme attuate per uniformarci al contesto Comunitario, vertevano sulla riduzione dei tempi e sulla implementazione della multidisciplinarietà della formazione specialistica, con il rischio di adombrare quelli che sono i punti di forza del nostro Sistema Sanitario, tra cui l’alto livello assistenziale dei nostri ospedali territoriali. La Scuola di Specializzazione di Chirurgia Generale dell’UNIVPM da alcuni anni punta su un progetto che vede la Clinica Universitaria al Centro di una Formazione Specialistica che si sviluppa sempre più sul territorio, avvicinando il mondo Ospedaliero a quello Universitario. Questo nuovo modello organizzativo prevede una prima fase all’interno della Clinica Universitaria ed una seconda nella Rete Formativa, nella quale rientrano Centri a differente impatto specialistico, all’interno di Strutture Ospedaliere Italiane ed Estere, e la possibilità di poter collaborare con l’Organizzazione di Emergency. Per testare questa nuova organizzazione del Corso Specialistico, abbiamo preso in analisi l’attività chirurgica svolta dagli specializzandi del nostro Ateneo, che hanno terminato il loro percorso formativo in Chirurgia Generale a Marzo 2014, essendo loro i primi ad aver beneficiato di questo modello. L’attività operatoria è stata, per ciascuno, mediamente di 400 interventi da primo operatore (237-476) distribuiti in chirurgia maggiore 44 (13-80), media 172 (129-268) e minore 209 (70-378), rapportando i loro risultati con gli standard complessivi di addestramento professionalizzante previsti dallo Statuto Nazionale si osserva il buon rendimento di questo sistema, che vede i suoi punti di forza nell’EQUITA dell’offerta, in quanto standardizzabile; nel concetto di RETE

  7. Malignant rectal melanoma. Case report.

    PubMed

    Morlino, Andrea; La Torre, Giuseppe; Vitagliano, Giulia; Cammarota, Aldo

    2015-03-26

    Il Melanoma Anorettale è una malattia rara e aggressiva ed è il terzo tipo più comune di melanoma maligno dopo quello della cute e della retina. Il sintomo più comune è il sanguinamento rettale, che è spesso scambiato per sanguinamento associato a emorroidi. La diagnosi è molto difficile, e quella iniziale può essere corretta solo in circa 80% dei casi. Il caso clinico che proponiamo riguarda un uomo di 71 anni giunto alla nostra osservazione per dolore anale, tenesmo rettale, sanguinamento. L’eplorazione rettale ci ha mostrato una neofromazione dolorosa, di colorito brunastro nel canale anale. La colonscopia e la endoscopia hanno evidenziato la presenza di una grande massa stenotica interessante il canale anale ed il retto con un diametro di circa 90 mm. La biopsia è positiva per melanoma a cellule maligne pigmentate. La TAC ha mostrato un ispessimento della parete rettale e linfonodi nel tessuto adiposo, nel distretto otturatore bilaterale e metastasi polmonari bilaterali. Il dato di laboratorio del Ca 19-9 è nei livelli normali. Il paziente è stato sottoposto a resezione addomino-perineale con dissezione linfonodale. Non ci sono studi dimostranti che la resezione radicale del melanoma primario ano-rettale è associata ad un miglioramento del controllo locale e della sopravvivenza. I pazienti con malattia localizzata dovrebbero essere sottoposti a escissione locale ogniqualvolta ciò sia tecnicamente fattibile. Il ruolo predominante del trattamento chemio radioterapico preoperatorio è quello di ridurre le recidive locoregionale e della cavità pelvica, e per ottenere un più alto tasso di conservazione dell’apparato sfinteriale. Inoltre facilita la rimozione delle potenziali micrometastasi e riduce le metastasi a distanza.

  8. Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade.

    PubMed

    Yang, Dong-Lei; Yao, Jian; Mei, Chuan-Sheng; Tong, Xiao-Hong; Zeng, Long-Jun; Li, Qun; Xiao, Lang-Tao; Sun, Tai-ping; Li, Jigang; Deng, Xing-Wang; Lee, Chin Mei; Thomashow, Michael F; Yang, Yinong; He, Zuhua; He, Sheng Yang

    2012-05-08

    Plants must effectively defend against biotic and abiotic stresses to survive in nature. However, this defense is costly and is often accompanied by significant growth inhibition. How plants coordinate the fluctuating growth-defense dynamics is not well understood and remains a fundamental question. Jasmonate (JA) and gibberellic acid (GA) are important plant hormones that mediate defense and growth, respectively. Binding of bioactive JA or GA ligands to cognate receptors leads to proteasome-dependent degradation of specific transcriptional repressors (the JAZ or DELLA family of proteins), which, at the resting state, represses cognate transcription factors involved in defense (e.g., MYCs) or growth [e.g. phytochrome interacting factors (PIFs)]. In this study, we found that the coi1 JA receptor mutants of rice (a domesticated monocot crop) and Arabidopsis (a model dicot plant) both exhibit hallmark phenotypes of GA-hypersensitive mutants. JA delays GA-mediated DELLA protein degradation, and the della mutant is less sensitive to JA for growth inhibition. Overexpression of a selected group of JAZ repressors in Arabidopsis plants partially phenocopies GA-associated phenotypes of the coi1 mutant, and JAZ9 inhibits RGA (a DELLA protein) interaction with transcription factor PIF3. Importantly, the pif quadruple (pifq) mutant no longer responds to JA-induced growth inhibition, and overexpression of PIF3 could partially overcome JA-induced growth inhibition. Thus, a molecular cascade involving the COI1-JAZ-DELLA-PIF signaling module, by which angiosperm plants prioritize JA-mediated defense over growth, has been elucidated.

  9. Septic complications involving hand and wrist in patients with pre-existing rheumatoid arthritis: The role of magnetic resonance imaging and sonography.

    PubMed

    Bortolotto, C; Gregoli, B; Coscia, D R; Draghi, F

    2012-06-01

    Sommario SCOPO DEL LAVORO: L'artrite settica (SA), che spesso coinvolge mano e polso, è comune nei pazienti con artrite reumatoide (AR) a causa dell'eziologia immunomediata della AR e dell'uso di farmaci immunosoppressivi. Le caratteristiche cliniche e di laboratorio possono non essere utili per distinguere tra recidiva di AR e sovrapposizione di SA. Il ruolo della risonanza magnetica (RM) è stata descritto in diversi studi. Il nostro obiettivo è quello di valutare il ruolo della ecografia (US). Materiali e Metodi. Negli ultimi 4 anni sono stati eseguiti 31 esami di risonanza magnetica della mano e del polso nel sospetto di SA come complicanza di AR. È stata utilizzata una risonanza magnetica da 1.5 T (Siemens Symphony, Erlangen, Germania) con protocollo standardizzato, che comprendeva la somministrazione di mezzo di contrasto; è stata eseguita anche un'ecografia con power Doppler utilizzando un ecografo Philips IU22. RISULTATI: Sono stati analizzati undici punti (secondo lo studio di Graif) per ogni esame di RM e di US. Alla RM il versamento articolare (37,5% di recidiva AR vs 100% sovrapposizioni di SA) e l'edema dei tessuti molli (25% vs 100%) erano indicativi di SA. Anche ecograficamente il versamento articolare (31.3% di AR recidiva 73,3% vs sovrapposizione di SA) e l'edema dei tessuti molli (12,5% vs 60%) erano indicativi di SA. CONCLUSIONE: I nostri risultati confermano che il versamento articolare e l'edema dei tessuti molli sono suggestivi per sovrapposizione di SA e che la RM è più sensibile nella loro valutazione. Anche se l'US è meno sensibile della RM, essa è importante nel guidare procedure invasive e nella valutazione dei pazienti che non possono essere sottoposti a RM.

  10. Sonographic evaluation of the temporomandibular joints in juvenile idiopathic arthritis().

    PubMed

    Melchiorre, D; Falcini, F; Kaloudi, O; Bandinelli, F; Nacci, F; Matucci Cerinic, M

    2010-03-01

    Sommario INTRODUZIONE: L'artrite Idiopatica giovanile (AIG) determina alterazioni a carico della testa condilare dell'articolazione temporomandibolare (ATM). Nell'esordio oligo-articolare (OA) l'interessamento dell'ATM viene spesso trascurato perchè può essere asintomatico. Lo scopo di questo studio è quello di valutare la presenza di versamento intrarticolare (V) dell'ATM, mediante esame ecografico (US), nelle fasi precoci di malattia. MATERIALE E METODI: Sono stati studiati 68 bambini (57 bambine e 11 bambini, di età compresa tra 9,1 e 16, anni, età media: 11,02 ± 4,2 mesi) con AIG ad esordio OA. I pazienti (pz) erano sintomatici quando uno dei quattro sintomi seguenti era presente: 1) dolore ricorrente (a riposo o durante il movimento di apertura della bocca); 2) presenza di scrosci articolari; 3) presenza di limitazione nell'apertura della bocca; 4) locking intermittente. US è stato eseguito su entrambe le ATM sia in fase statica che dinamica, mediante ecografo General Electric (LOGIQ7) con sonda lineare (8,5 MHz) posizionata lungo l'asse maggiore del ramo condilare. Il V era presente quando lo spessore della capsula articolare era ≥1,5 mm. RISULTATI: 46/68 (68%) hanno presentato V a carico delle ATM; in 16 (35%) il V era bilaterale. 2/46 con V erano sintomatici, mentre in 44 non erano presenti sintomi. CONCLUSIONI: Questi dati suggeriscono che un'alta percentuale di bambini e giovani adulti con AIG ad esordio OA, nella fase iniziale della malattia, presenta un interessamento flogistico delle ATM anche in assenza di sintomi. L'US, non invasivo e facilmente ripetibile, ci offre importanti informazioni sul coinvolgimento articolare delle ATM ed è risultato utile nella diagnosi all'esordio.

  11. Melena as presentation of primary small intestine inflammatory myofibroblastic tumor in an adult woman. A case report.

    PubMed

    Alloni, Rossana; Ancona, Gianluca; Gallo, Ida; Crescenzi, Anna; Coppola, Roberto

    2015-07-29

    È il caso di una paziente di 32 anni affetta da Miofibroblastoma non noto, trasferita da altra struttura sanitaria presso il nostro reparto perché affetta da melena da fonte non determinata. All’anamnesi risultava un precedente ricovero in altro Pronto Soccorso per un quadro clinico caratterizzato da dispnea, cefalea, tachicardia e astenia profonda., oltre a profonda anemia (Hg 5.8 g/dl). La gastroscopia non aveva evidenziato alcun motivo di sanguinamento e l’ecografia addomino-pelvica era risultata negativa. Dopo ripetute emotrasfusioni la tentata rettosigmoidoscopia era stata interrotto per intolleranza della paziente. Una volta stabilizzata si era proceduto al trasferimento presso la nostra struttura, e qui alla Risonanza Magnetica dell’addome veniva evidenziato, un ispessimento parietale esteso per 8 cm a del digiuno medio distale, in corrispondenza del fianco destro, antero – lateralmente al duodeno, ed adiacente ad esso una formazione ipervascolare solida di 20 mm. In prima ipotesi poteva trattarsi di un tratto invaginato del piccolo intestino con all’apice una lesione parietale solida, verosimile causa del sanguinamento. Persistendo il quadro anemico e avendo localizzato una lesione sospetta, la paziente è stata sottoposta ad intervento chirurgico, che portava alla conferma dell’esistenza di una lesione nodulare parietale del piccolo intestino, per cui si procedeva ad una sua resezione segmentaria comprendente la suddetta massa, sottoponendo il pezzo operatorio ad esame istologico definitivo. L’anatomo-patologo formulava la diagnosi isto-immunologica di pseudotumore infiammatorio (c.d. Tumore miofibroblastico infiammatorio) responsabile di invaginazione digiuno-digiunale. I margini di resezione risultavano indenni. Dimessa dopo un decorso postoperatorio senza complicanze, al follow-up di 6 mesi non si è ripresentato alcun sintomo di nuovo sanguinamento. Il sanguinamento della neoformazione responsabile della melena da fonte ignota era

  12. Minilaparoscopic cholecystectomy a one year record.

    PubMed

    Di Bartolomeo, Nicola; Mascioli, Federico; Ciampaglia, Franco

    2015-01-01

    Negli ultimi anni, alcuni chirurghi hanno cercato di rendere sempre meno invasiva la procedura della colecistectomia videolaparoscopica, riducendo il calibro degli strumenti. Nel nostro studio si vogliono dimostrare i vantaggi nell’utilizzo di strumenti miniaturizzati (con diametro di 3mm), comparandoli con la colecistectomia laparoscopica realizzata con strumenti da 5mm. I parametri analizzati nello studio sono: la durata dell’intervento, la durata della degenza, il dolore postoperatorio, le complicanze ed il risultato estetico. Lo studio si basa su una casistica personale di 114 pazienti trattati in un periodo di 12 mesi. Tutti i pazienti sono stati trattati per calcolosi sintomatica della colecisti o per poliposi della colecisti. In 102 pazienti si è trattato di colecistectomia minilaparoscopica e in 12 colecistectomia laparoscopica con strumenti da 5mm o perchè presentavano un eccessivo spessore delle pareti della colecisti che rendeva difficoltosa la presa sull’organo con strumenti di 3mm, o perchè presentavano calcoli lungo la via biliare principale e si rendeva quindi necessario eseguire una colangiografia intraoperatoria. L’esecuzione della tecnica minilaparoscopica richiede particolari accorgimenti per superare piccole difficoltà tecniche in rapporto alla maggiore flessibilità degli stumenti di ridotto calibro e all’impossibilità di applicare clips metalliche con i trocars da 3mm. E’ necessario legare con filo di sutura il dotto cistico mediante nodi intracorporei e coagulare l’arteria cistica con corrente monopolare. La durata dell’intervento risulta in media di 47 minuti per la colecistectomia con strumenti da 5mm e di 50 minuti per la colecistectomia minilaparoscopica. La degenza media è stata di 49 ore per la colecistectomia con strumenti da 5mm e di 18 ore per la colecistectomia minilaparoscopica; 73 pazienti sono stati dimessi lo stesso giorno dell’intervento. Il dolore post operatorio è risultato inferiore nei pazienti

  13. Cochlea size variability and implications in clinical practice.

    PubMed

    Pelliccia, P; Venail, F; Bonafé, A; Makeieff, M; Iannetti, G; Bartolomeo, M; Mondain, M

    2014-02-01

    Gli obbiettivi di questo studio sono stati: 1) lo studio della variabilità delle dimensioni cocleari in relazione all'età e al grado di ipoacusia; 2) calcolare la lunghezza dell'elettrodo dell'impianto cocleare richiesta per ottenere l'angolo ideale d'inserzione profonda di 270°. Per raccogliere i dati riguardanti le ossa temporali sono stati inclusi nello studio 241 pazienti (482 ossa temporali) che hanno ricevuto una Tomografia Computerizzata a alta risoluzione (HRCT) dell'orecchio nel nostro Policlinico Universitario tra il 2003 e il 2008; i pazienti sono stati divisi in 3 Gruppi: 97 (194 orecchie) aventi una ipoacusia neurosensoriale severa o profonda bilaterale (Gruppo A), 70 (140 orecchie) aventi una ipoacusia neurosensoriale moderata bilaterale (Gruppo B), 74 pazienti (148 orecchie) senza ipoacusia neurosensoriale o mista (gruppo C). In ciascuno dei 3 gruppi, sono stati identificati 5 sottogruppi in base all'età: 1) sottogruppo 1: soggetti ≤ 5 anni, 2) sottogruppo 2: soggetti da 6 a 10 anni; 3) sottogruppo 3: pazienti da 11 a 15 anni, 4) sottogruppo 4: pazienti da 16 a 20 anni, 5) sottogruppo 5: soggetti >; 20 anni. Sono stati misurati la lunghezza della coclea (L), l'altezza della coclea (H), il diametro del lume del giro basale (BTLD) e il Volume della coclea (V). Il Test di Mann-Whitney è stato utilizzato per verificare l'ipotesi alternativa che a livello di queste dimensioni esiste una differenza statisticamente significativa tra i differenti gruppi e sottogruppi. La seguente equazione è stata adottata per calcolare la Lunghezza di un elettrodo rettilineo che segue la parete esterna della scala timpani necessaria per ottenere l'angolo ideale di inserzione profonda di 270° (LIC): [Formula: see text]. Secondo i nostri risultati alla nascita la coclea è completamente sviluppata e ha già raggiunto le dimensioni dell'adulto. Il Grado di ipoacusia non influenza la Lunghezza (L) e il Volume (V) della coclea, mentre può influenzare la sua altezza (H

  14. Multimodality imaging of bilateral pheochromocytoma. A case report.

    PubMed

    Paladino, Nunzia Cinzia; Lowery, Aoife; Guérin, Carole; Taïeb, David; Sebag, Frédéric

    2015-06-22

    I feocromocitomi bilaterali sono rari; nella maggior parte dei casi presentano origine ereditaria e sono legati a mutazioni germinali relative ai geni RET, VHL o SDHx, tuttavia in altri casi non viene ritrovata alcuna eziologia. A tal proposito riportiamo il caso clinico di una donna di 76 anni, giunta alla nostra osservazione per malessere generale sopravvenuto in concomitanza di crisi ipertensive responsabili di ospedalizzazione. Il profilo ormonale realizzato in tale occasione, era suggestivo di feocromocitoma (metanefrine plasmatiche ed urinarie 10 volte superiori al range di normalità). Gli esami radiologici (TC e RMN) rivelavano due lesioni surrenaliche bilaterali di diametro rispettivamente a destra di 47 mm ed a sinistra di 26 mm. Mentre la TC definiva le dimensioni di queste lesioni, il loro carattere eterogeneo e la loro ipervascolarizzazione oltre ai rapporti con gli organi adiacenti, la RMN si esprimeva già in favore di feocromocitoma bilaterale. La scintigrafia alla MIBG mostrava una iperfissazione a carico della lesione surrenalica destra mentre sulla surrenale controlaterale evidenziava una fissazione limitata, relativa alla midollare normale. Tenuto conto del forte sospetto di feocromocitoma bilaterale, veniva eseguita una TEP alla 18F-FDOPA che mostrava un intenso ipermetabolismo a carico della massa surrenalica destra, mentre controlateralmente una fissazione simile a quella del fegato e pertanto non sospetta, nonostante molti studi sostengano una sensibilità uguale o addirittura superiore della TEP alla 18-FDOPA rispetto alla scintigrafia MIBG nei pazienti con feocromocitoma o paraganglioma. In un primo tempo veniva eseguita una surrenalectomia destra per via laparoscopica. In fase post-operatoria, in seguito alla constatazione del persistente incremento delle metanefrine plasmatiche ed urinarie, veniva realizzata una TEP alla 18 FDG che confermava la presenza di un’area di ipermetabolismo intenso a carico della lesione surrenalica sinistra

  15. Varicose veins: new trends in treatment in a Vascular Surgery Unit.

    PubMed

    Mazzaccaro, Daniela P; Stegher, Silvia; Occhiuto, Maria Teresa; Muzzarelli, Lorenzo; Malacrida, Giovanni; Nano, Giovanni

    2016-01-01

    La recente introduzione di tecniche meno invasive in alternativa al tradizionale stripping safenico ha rivoluzionato il trattamento delle vene varicose (VV), soprattutto nelle Unità Operative a prevalente indirizzo flebologico, ove la scleroterapia con mousse, il laser o la termoablazione con radiofrequenza (RFA) vengono applicate sempre più frequentemente con parallela riduzione del ricorso alle tecniche di chirurgia open. Nella nostra Unità Operativa Complessa di Chirurgia Vascolare, la patologia venosa viene affrontata da sempre, parallelamente a quella arteriosa; in particolare dal 2013, superata la prima fase di apprendimento, anche nella nostra Unità Operativa è stato introdotto l’uso sistematico della RFA per il trattamento dell’incontinenza della vena grande safena (VGS). Abbiamo dunque retrospettivamente esaminato la nostra esperienza nel trattamento delle VV con particolare analisi del modo in cui il nostro approccio terapeutico è cambiato nel corso degli ultimi anni. I dati di tutti i pazienti trattati consecutivamente dal 1 settembre 2013 al 31 Luglio 2015 per VV essenziali e recidive sono stati pertanto retrospettivamente raccolti e analizzati. L’analisi statistica è stata effettuata utilizzando il software JMP 5.1.2 (SAS Institute). Sono state trattate in totale 409 gambe in 378 pazienti. La percentuale di stripping della VGS per VV essenziali è diminuita nel corso degli anni (67% nel 2013 contro il 15.2% nel 2015), a differenza di quello che è successo alla percentuale della RFA della VGS (14.3% vs. 31.5% rispettivamente nel 2013 e nel 2015) e alla percentuale di gambe trattate con la tecnica ASVAL (8.7% vs 31.5%, rispettivamente, nel 2013 e nel 2015). Analogamente, nel 2013 la maggior parte delle procedure è stata eseguita utilizzando l’anestesia spinale (77.5%), mentre nel 2015 le tecniche anestesiologiche più utilizzate sono state l’anestesia locale e l’anestesia locale con sedazione (rispettivamente 35.9% e 29.3%). Il

  16. The Italian national survey of indoor radon exposure.

    PubMed

    Sciocchetti, G; Scacco, F; Baldassini, P G; Battella, C; Bovi, M; Monte, L

    1985-10-01

    An investigation is being developed by the Comitato Nazionale per la Ricerca e per lo Sviluppo dell'Energia Nucleare e delle Energie Alternative, ENEA, to assess the indoor exposure of the Italian population. The programme, which started in 1982, includes regional and local surveys in all the administrative districts and intensive investigations of factors which influence indoor radon levels. The survey is organized by statistical areas of sampling to obtain representative samples of houses. The definition of the areas takes into account basic parameters e.g. geolithological environments, radon soil gas from underlying soils and rocks, specific activities of local building materials, climatic and seasonal variations, building technology, types of houses and town planning. The collected data may also be used for the compilation of radon risk maps to plan special monitoring and remedial actions if needed. Preliminary results concerning the above items are discussed.

  17. The VLT Survey Telescope (VST) Project: a progress report

    NASA Astrophysics Data System (ADS)

    Capaccioli, Massimo; Cappellaro, Enrico; Mancini, Dario; Sedmak, Giorgio

    This is a report on the status of the VLT Survey Telescope (VST) project, a joint venture between ESO and the INAF - Capodimonte Astronomical Observatory, Naples, for the design, construction, and operation at Cerro Paranal of a 2.60 m wide-field imaging facility to support VLT as well as to carry on stand-alone observing programs. VST is not a traditional telescope; it is rather a highly specialized instrument, and cannot be considered disjointed from its camera. This is why some information will be also provided on the status of OmegaCAM, which is however an independent activity of ESO with the homonymous Consortium. Lacking space to illustrate this text, we refer to the collection of images about VST and its camera in the original Power Point presentation of this contribution downloadable at the address: http://www.na.astro.it/oacweb/oacweb_ ricerca/vst_ site.

  18. Integrated front-end electronics in a detector compatible process: source-follower and charge-sensitive preamplifier configurations

    NASA Astrophysics Data System (ADS)

    Ratti, Lodovico; Manghisoni, Massimo; Re, Valerio; Speziali, Valeria

    2001-12-01

    This study is concerned with the simulation and design of low-noise front-end electronics monolithically integrated on the same high-resistivity substrate as multielectrode silicon detectors, in a process made available by the Istituto per la Ricerca Scientifica e Tecnologica (ITC-IRST) of Trento, Italy. The integrated front-end solutions described in this paper use N-channel JFETs as basic elements. The first one is based upon an all-NJFET charge preamplifier designed to match detector capacitances of a few picofarads and available in both a resistive and a non resistive feedback configuration. In the second solution, a single NJFET in the source-follower configuration is connected to the detector, while its source is wired to an external readout channel through an integrated capacitor.

  19. Morpho-physiolological and qualitative traits of a bread wheat collection spanning a century of breeding in Italy

    PubMed Central

    Laino, Paolo; Limonta, Margherita; Gerna, Davide

    2015-01-01

    Abstract Evaluation and characterization are crucial steps in the exploitation of germplasm collections. The Sant’Angelo Lodigiano unit of the Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria (CREA) maintains a broad collection of Triticum spp, including more than 4000 genotypes of T. aestivum. Such collection represents a wide source of genetic variability for many agronomic and qualitative traits, extremely useful in modern breeding programs. The collection size, however, makes very difficult its management as a whole. A reduced subset, representing the process of wheat breeding in Italy during the last hundred years, was hence identified for an in-depth characterization. The lines were cropped in two locations over two growing seasons, and analyzed using 16 morpho-agronomic and qualitative descriptors. Most of the analysed characters showed a broad variation throughout the collection, allowing to follow the plant ideotype changes across the breeding progress in Italy during the 20th century. PMID:26379457

  20. Genetic Biodiversity of Italian Olives (Olea europaea) Germplasm Analyzed by SSR Markers

    PubMed Central

    Vendramin, Giuseppe Giovanni; Chiappetta, Adriana

    2014-01-01

    The olive is an important fruit species cultivated for oil and table olives in Italy and the Mediterranean basin. The conservation of cultivated plants in ex situ collections is essential for the optimal management and use of their genetic resources. The largest ex situ olive germplasm collection consists of approximately 500 Italian olive varieties and corresponding to 85% of the total Italian olive germplasm is maintained at the Consiglio per la Ricerca e sperimentazione per l'Agricoltura, Centro di Ricerca per l'Olivicoltura e l'Industria Olearia (CRA-OLI), in Italy. In this work, eleven preselected nuclear microsatellite markers were used to assess genetic diversity, population structure, and gene flows with the aim of assembling a core collection. The dendrogram obtained utilizing the unweighted pair group method highlights the presence of homonymy and synonymy in olive tree datasets analyzed in this study. 439 different unique genotype profiles were obtained with this combination of 11 loci nSSR, representing 89.8% of the varieties analyzed. The remaining 10.2% comprises different variety pairs in which both accessions are genetically indistinguishable. Clustering analysis performed using BAPS software detected seven groups in Italian olive germplasm and gene flows were determined among identified clusters. We proposed an Italian core collection of 23 olive varieties capturing all detected alleles at microsatellites. The information collected in this study regarding the CRA-OLI ex situ collection can be used for breeding programs, for germplasm conservation, and for optimizing a strategy for the management of olive gene pools. PMID:24723801

  1. Morphological variability in leaves and molecular characterization of novel table grape candidate cultivars (Vitis vinifera L.).

    PubMed

    Alba, Vittorio; Bergamini, Carlo; Cardone, Maria Francesca; Gasparro, Marica; Perniola, Rocco; Genghi, Rosalinda; Antonacci, Donato

    2014-06-01

    The present work report the characterization of twenty-one table grapes candidate cultivars plus five registered ones included as reference, by means of 47 ampelographic traits, 23 ampelometric measurements and six microsatellite loci. The final goal of the research was to analyse the possibility of reducing the number of morphological and molecular tools required for a precise and effective description of a grape genotype or cultivar. This would be of great help for future biodiversity description on a larger sample of more than 300 table grapes accessions today grown at the 'Consiglio per la Ricerca e la sperimentazione in Agricoltura (C.R.A.)-Unità di ricerca per l'uva da tavola e la vitivinicoltura in ambiente mediterraneo (Bari-Italy)'. OIV ampelographic traits showed a clear distinction among all twenty-six genotypes analysed, suggesting the relevant morphological variability investigated. Principal component analysis based on ampelometric traits revealed main veins ON(3), ON(4) and O(3)N(4); ratios between main veins; angles between main veins and of petiolar sinus, to be the most effective records in differentiating cultivars, for a total variation of 69.9 % described by the first three components. Molecular analysis based on six microsatellite loci was performed on all genotypes, providing a detailed molecular profile and a dendrogram of genetic similarity, in which all genotypes were clearly distinguishable. Finally, with the goal of using the minimum possible number of markers to differentiate genotypes, microsatellites VVMD5 and VVMD27 were selected to be sufficient to distinguish among all the candidate cultivars included in the analysis, representing a possible 'step by step' approach when a molecular characterization has to be undertaken on a large number of genotypes, by first testing few markers and increasing their number only if necessary.

  2. [Pietro d'Abano and the astrological and scientific image in Padova during the XIV century: from Giotto to Carraresi].

    PubMed

    Mariani Canova, Giordana

    2008-01-01

    The paper intends to prove the incidence that scientific doctrines, mostly Pietro d'Abano's astrological and medical studies, had on Giotto's painting at the Cappella degli Scrovegni in Padova and his lost astrological cycle in the Sala della Ragione. It is emphasized how in no other painting of his, Giotto displayed as much intellectualism as in the Cappella degli Scrovegni. There we can note the importance of the physical representation of the sky and stars and figures' particular physiognomic characterization referable to Pietro d'Abano's theories presented in his astrological treatises and in his Compilation Phisionomiae. Even the ecceptional botanical realism displayed in the representation of plants can be probably referred to Pietro d'Abano's scientific teaching. An hypotetical reconstruction, according to Ptolomeus' theories and Pietro d'Abano's physiognomic, of Giotto's astrological cycle in the Sala della Ragione is also proposed.

  3. The museum of unnatural form: a visual and tactile experience of fractals.

    PubMed

    Della-Bosca, D; Taylor, R P

    2009-01-01

    A remarkable computer technology is revolutionizing the world of design, allowing intricate patterns to be created with mathematical precision and then 'printed' as physical objects. Contour crafting is a fabrication process capable of assembling physical structures the sizes of houses, firing the imagination of a new generation of architects and artists (Khoshnevisat, 2008). Daniel Della-Bosca has jumped at this opportunity to create the 'Museum of Unnatural Form' at Griffith University. Della-Bosca's museum is populated with fractals sculptures - his own versions of nature's complex objects - that have been printed with the new technology. His sculptures bridge the historical divide in fractal studies between the abstract images of mathematics and the physical objects of Nature (Mandelbrot, 1982). Four of his fractal images will be featured on the cover of NDPLS in 2009.

  4. Galileo's Lens

    NASA Astrophysics Data System (ADS)

    Manos, Harry

    2003-05-01

    Most visitors to Florence, Italy, know about the Galleria dell'Accademia, housing Michelangelo's famous statue of David, or the Galleria degli Uffizi with the famous Medici collection. Few visitors know that only two blocks from the Uffizi on the Arno River is one of the world's finest museums featuring historic scientific instruments, the Museo di Storia della Scienza. In the February issue of TPT, Nickell states that the Museo di Storia della Scienza ``is perhaps the best museum on the history of science in the world.''1 This fact is likely true, and the museum is a must for physics teachers visiting Florence. It features a vast collection of authentic ``cutting-edge'' scientific instruments, including one of Galileo's lenses in a magnificent ebony and ivory frame. One of the tragedies is that this museum goes unmarked on many tourist maps and unmentioned in many guidebooks.

  5. IL TRAPIANTO ORTOTOPICO DEL FEGATO

    PubMed Central

    STARZL, THOMAS E.

    2010-01-01

    E’ormai noto che esiste la possibilità rivoluzionaria di utilizzare il fegato per il trattamento della stadio terminale delle epatopatie. Nel gennaio 1980 si celebra il decimo anna di sopravvivenza con fegato trapiantato (la più lunga della letteratura) di un paziente da noi trattato. Si tratta di uno dei 12 malati sottoposti a trapianto e seguiti per più di 5 anni. La nota positiva di questa tipo di trattamento è rappresentata dall’eccellente tenore di vita che i pazienti conducono e dalla riabilitazione sociale e professionale. La nota negativa è data, invece, dal fatto che i buoni risultati non vengono raggiunti con regolarità e non possono essere previsti con esattezza. In questa breve rassegna considereremo la esperienza da noi fatta presso l’Università di Denver nel Colorado, mettendo in risalto le cause dell’elevata mortalità precoce e le prospettive future di questa mezzo terapeutico. PMID:21572898

  6. [Archives for the history of malaria].

    PubMed

    Prosperi, Margherita Bettini

    2006-01-01

    Archives for the history of malaria and malariology in Italy have been 'rediscovered' in the recent past. The Sezione di Storia della Medicina at Rome University conserves many different personal and institutional archives closely or loosely related to this topic. Many of them had been originally gathered and kept at the Istituto di Igiene at Rome University. Among them the Fondo Casini, of the 20th century, documenting the activity of public institutions such as the Società per gli Studi della Malaria and the Scuola Superiore di Malariologia; archives of the end of the 19th and beginning of the 20th century, such as the Fondo Bignami, Celli; and many others.

  7. Low Voltage Low Light Imager and Photodetector

    NASA Technical Reports Server (NTRS)

    Nikzad, Shouleh (Inventor); Martin, Chris (Inventor); Hoenk, Michael E. (Inventor)

    2013-01-01

    Highly efficient, low energy, low light level imagers and photodetectors are provided. In particular, a novel class of Della-Doped Electron Bombarded Array (DDEBA) photodetectors that will reduce the size, mass, power, complexity, and cost of conventional imaging systems while improving performance by using a thinned imager that is capable of detecting low-energy electrons, has high gain, and is of low noise.

  8. Excitation of Self-Localized Spin-Wave Bullets by Spin-Polarized Current in In-Plane Magnetized Magnetic Nano-Contacts: A Micromagnetic Study

    DTIC Science & Technology

    2007-10-08

    Melkov,3 Vasil Tiberkevich,4 and Andrei N. Slavin4 1Dipartimento di Fisica della Materia e Tecnologie Fisiche Avanzate, University of Messina...but finite-amplitude initial perturbations of magnetization are necessary to generate a bullet in our numerical simulations, where thermal...reaches the limit cycle representing the microwave generation . This threshold value is the same for both models of dissipation with q1=3 and q1=0 and is

  9. [Waiting time between acute event and rehabilitation: continuity of nursing care and rehabilitation. Analysis and suggestions for a Service of Protected Discharge].

    PubMed

    D'Ilio, Ilaria; Raimondi, Anna Maria; Radice, Laura; Di Mauro, Stefania

    2014-01-01

    INTRODUZIONE. In Italia negli ultimi anni l’aumento della sopravvivenza della popolazione ha comportato il cambiamento dello stato di salute, che vede l’incremento nella prevalenza delle patologie croniche (Osservatorio, 2011). L’ospedale, riservato alla fase acuta delle patologie, si integra necessariamente con le cure primarie. La continuità assume particolare rilevanza per la cura, assistenza e riabilitazione della persona assistita, così come l’appropriato utilizzo delle diverse tipologie di offerta socio sanitaria assistenziale e riabilitativa. OBIETTIVO. Al San Gerardo di Monza, nell’ambito della riabilitazione del paziente post-acuto, si analizza la fase che intercorre tra la dimissione prevista dall’ospedale e la data di accettazione presso gli istituti di riabilitazione. E’ possibile quantificare i tempi di attesa? L’ allocazione delle persone assistite è appropriata? Scopo dello studio osservazionale descrittivo è accertare la distribuzione dei giorni di attesa. Inoltre si ipotizza il ricorso all’Assistenza Domiciliare Integrata e a soluzioni innovative. Obiettivi sono la diminuzione delle giornate di degenza inappropriate e l’utilizzo delle risorse in modo congruo. RISULTATI. Delle 1083 persone in attesa di riabilitazione il 55% (652), a cui sono associate 4505 giornate “inappropriate”, è stato dimesso dall’ospedale oltre i tempi previsti. CONCLUSIONI. L’utilizzo dell’assistenza domiciliare, vantaggiosa per l’ospedale, può essere utilizzata solo per una minoranza di pazienti e in modo diseconomico. Per abbattere la totalità delle giornate, una soluzione innovativa può essere l’istituzione di posti letto a basso costo. E dato che la maggioranza dei casi sono solo ad alta complessità assistenziale ma a bassa intensità clinica potrebbero essere letti gestiti da infermieri.

  10. Duplex Doppler ultrasound study of the temporomandibular joint.

    PubMed

    Stagnitti, A; Marini, A; Impara, L; Drudi, F M; Lo Mele, L; Lillo Odoardi, G

    2012-06-01

    Sommario INTRODUZIONE: La fisiologia articolare dell’articolazione temporo-mandibolare (ATM) può essere esaminata sia dal punto di vista clinico che strumentale. La diagnostica per immagini ha da tempo contribuito con la risonanza magnetica (RM) e anche con la radiografia (Rx) e la tomografia computerizzata (TC) all’analisi della morfologia dei capi articolari e della cinetica condilare. L’esame duplex-ecodoppler è una metodica di largo impiego nello studio delle strutture in movimento in particolar modo a livello delle strutture del sistema vascolare. MATERIALI E METODI: È stata utilizzata un’apparecchiatura Toshiba APLIO SSA-770A, con l’uso di tecnica duplex-ecodoppler multi display, che consente la visualizzazione contemporanea dell’immagine ecografica e dei segnali Doppler utilizzando una sonda lineare del tipo phased array con cristalli trasduttori funzionanti ad una frequenza fondamentale di 6 MHz per gli spettri Doppler pulsati e 7.5 MHz per l’imaging ecografico. Sono stati esaminati nel Dipartimento di Scienze Radiologiche, Oncologiche e Anatomo-patologiche dell’Università “Sapienza” di Roma, 30 pazienti del reparto di Ortognatodonzia dell’Istituto di Odontoiatria della stessa Università. RISULTATI: Nei pazienti normali si è ottenuta un’alternanza regolare degli spettri Doppler, mentre nei soggetti con disfunzioni del complesso condilo-meniscale, si è persa la regolarità della sommatoria degli spettri di Fourier, con altezze incostanti in relazione a spostamenti irregolari del complesso condilo-meniscale. CONCLUSIONI: L’esame ecodoppler si è dimostrato, in tutti i pazienti, capace di discriminare quelli normali dai patologici e tra questi ultimi ha permesso di identificare gli aspetti più significativi delle patologie disfunzionali.

  11. Bibliography of Leishmania and Leishmanial Diseases. Volume 1

    DTIC Science & Technology

    1980-06-01

    DE ANATOMIA PATOLOGICA, ARCIJIVOS CARDIOLOGIA Y HEMATO- PATOLOGIA CORRELATIVA E NEURO- LOGIA. Madrid. ERGENOLOGIA. Coimbra. S ZR 1 AL P U BL I C A...VETERINARA. Publicatiune a DE ANATOMIA Normal y Paiolo’gica. Corpulul dida’ctic’ al Facultitei de Medi- Buenos Aires. cini Veterinarl BVCUREITI. Arch. Soc...ESPANOLA Trn DE BIOLOGIA.’ Madrid. BOLLETTINO DEI NICSEI-’Dl ZOOLOGIA E DI ANATOMIA COMPARATA DELLA REALE VNIVERSITA, DI TORINO. Bol. Soc. Esp. Hint. Nat

  12. Riverine Carbon and the Sedimentary Record on the Continental Shelves

    DTIC Science & Technology

    2004-09-30

    formerly Istituto di Geologia Marina) Consiglio Nazionale delle Ricerche Via Gobetti, 101 40129 Bologna, Italy phone: +39 (051) 6398880 Fax. +39 (051...Geologia Marina,,(formerly Istituto di Geologia Marina),Consiglio Nazionale delle Ricerche,, Via Gobetti, 101,40129 Bologna, Italy, , 8. PERFORMING...Tesi T. 2004. Dispersione del carbonio organico di origine fluviale sul lato occidentale della piattaforma continentale adriatica. Ciclo del Carbonio

  13. Radioprotective Drugs: A Synopsis of Current Research and a Proposed Research Plan for the Federal Emergency Management Agency.

    DTIC Science & Technology

    1985-04-01

    Lawrence Livermore National Laboratory *P.O. Box 808 2431D Livermore, CA 94550 ______ 11. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE April 1985...administration of drugs is preferred, to give the highest degree of control possible. Specific tumors are to be made more sensitive to radiation, while the...PJlanification c/Evaristo San Miguel, 8 Madrid-8 SPAIN Ministero dell Interno * ~Direzione Generale della -’- - Protezione Civile 00100 Rome ITALY

  14. The ecological importance of mixed-severity fires: Nature's phoenix [Book Review

    Treesearch

    Carolyn H. Sieg

    2016-01-01

    The stated goal of a recent book, The Ecological Importance of Mixed-Severity Fires: Nature’s Phoenix, edited by Dominick A. DellaSala and Chad T. Hansen, is to provide a global reference on the benefits of mixed- and high-severity fires. Note that the goal is not to provide an objective reference on the ecological aspects of mixed- and high-severity fires. Rather, the...

  15. Transcriptional mechanisms associated with seed dormancy and dormancy loss in the gibberellin-insensitive sly1-2 mutant of Arabidopsis thaliana

    PubMed Central

    Nelson, Sven K.

    2017-01-01

    While widespread transcriptome changes were previously observed with seed dormancy loss, this study specifically characterized transcriptional changes associated with the increased seed dormancy and dormancy loss of the gibberellin (GA) hormone-insensitive sleepy1-2 (sly1-2) mutant. The SLY1 gene encodes the F-box subunit of an SCF E3 ubiquitin ligase needed for GA-triggered proteolysis of DELLA repressors of seed germination. DELLA overaccumulation in sly1-2 seeds leads to increased dormancy that can be rescued without DELLA protein destruction either by overexpression of the GA receptor, GA-INSENSITIVE DWARF1b (GID1b-OE) (74% germination) or by extended dry after-ripening (11 months, 51% germination). After-ripening of sly1 resulted in different transcriptional changes in early versus late Phase II of germination that were consistent with the processes known to occur. Approximately half of the transcriptome changes with after-ripening appear to depend on SLY1-triggered DELLA proteolysis. Given that many of these SLY1/GA-dependent changes are genes involved in protein translation, it appears that GA signaling increases germination capacity in part by activating translation. While sly1-2 after-ripening was associated with transcript-level changes in 4594 genes over two imbibition timepoints, rescue of sly1-2 germination by GID1b-OE was associated with changes in only 23 genes. Thus, a big change in sly1-2 germination phenotype can occur with relatively little change in the global pattern of gene expression during the process of germination. Most GID1b-OE-responsive transcripts showed similar changes with after-ripening in early Phase II of imbibition, but opposite changes with after-ripening by late Phase II. This suggests that GID1b-OE stimulates germination early in imbibition, but may later trigger negative feedback regulation. PMID:28628628

  16. Non-Lethal Weapons and Future Peace Enforcement Operations (Les armes non letales dans les operations d’imposition de la paix)

    DTIC Science & Technology

    2004-11-01

    vehicle airbag technology. A detection device or sensor or alternatively a manual , remote control, may trigger the device. b) Advantages and...vehicle mines to prevent their removal. Remote-controlled devices which can only be triggered manually by a combatant, and not simply “by the presence...Box 2715 Centro di Documentazione DK-2100 Copenhagen Ø Tecnico -Scientifica della Difesa ROYAUME-UNI Via XX Settembre 123 Dstl Knowledge Services

  17. NATO RTO Space Science and Technology Advisory Group (SSTAG) Recommendations for Space Research Topics

    DTIC Science & Technology

    2007-02-01

    Manual , On-screen Digitizing, Spectral Change Vectors, Knowledge-Based Vision Systems. • Degradation of environment as a result of training activities...K1A 0K2 ITALIE ROUMANIE DANEMARK Centro di Documentazione Romanian National Distribution Danish Acquisition and Logistics Tecnico -Scientifica...944 ITALY SDG TECEN / DGAM PO Box 18 Centro di Documentazione C/ Arturo Soria 289 197 21 Praha 9 Tecnico -Scientifica della Difesa Madrid 28033 Via

  18. Worldwide Report, Telecommunications Policy, Research and Development, No. 258

    DTIC Science & Technology

    1983-01-28

    Telecommunications Firm 45 WEST EUROPE ITALY New Technique for Precision DME of Microwave Landing System (Franco Chiarini , et al.; ALTA FREQUENZA, Sep...Article by Franco Chiarini , Mauro Gori, Francesco Vatalaro, of Laboratorio Central Industrie Face Standard-Pomezia, and Giorgio Corazza, Gabriele...Spring 1980. [8] F. Chiarini , M. Gori: Possibilitä di miglioramento della precisione di un DME in banda L öfferta da u’n sistema di antenne a

  19. Introduzione al Laboratorio di Fisica

    NASA Astrophysics Data System (ADS)

    Ciullo, Giuseppe

    La Fisica (dal greco τὰ ϕυσικὰ: le cose naturali) si pone l'obiettivo di descrivere e prevedere il comportamento dei fenomeni naturali, nonché degli apparati e degli strumenti, che hanno reso e rendono la nostra vita più comoda ed efficiente. Tale obiettivo viene perseguito mediante un'attenta osservazione dei fenomeni, con una conseguente schematizzazione dell'osservazione, per fornire una conoscenza della realtà oggettiva, affidabile, verificabile e condivisibile.

  20. Long-distance transport of Gibberellic Acid Insensitive mRNA in Nicotiana benthamiana.

    PubMed

    Xu, Haiyan; Iwashiro, Reika; Li, Tianzhong; Harada, Takeo

    2013-10-21

    The Gibberellic Acid (GA) signal is governed by the GAI (Gibberellic Acid Insensitive) repressor, which is characterized by a highly conserved N-terminal DELLA domain. Deletion of the DELLA domain results in constitutive suppression of GA signaling. As the GAI transcript is transportable in phloem elements, a Δ-DELLA GAI (gai) transgenic stock plant can reduce the stature of a scion through transport of gai mRNA from the stock. However, little is known about the characteristics of a scion on a gai stock. Arabidopsis Δ-DELLA GAI (gai) was fused with a T7 epitope tag and expressed under the control of a companion cell-specific expression promoter, Commelina yellow mottle virus promoter (CoYMVp), to enhance transport in the phloem. The CoYMVp:Atgai-T7 (CgT) transgenic Nicotiana benthamiana exhibited a dwarf phenotype and lower sensitivity to GA enhancement of shoot stature. A wild-type (WT) scion on a CgT stock contained both Atgai-T7 mRNA and the translated product. Microarray analysis to clarify the effect of the CgT stock on the gene expression pattern in the scion clearly revealed that the WT scions on CgT stocks had fewer genes whose expression was altered in response to GA treatment. An apple rootstock variety, Malus prunifolia, integrating CoYMVp:Atgai moderately reduced the tree height of the apple cultivar scion. Our results demonstrate that Atgai mRNA can move from companion cells to sieve tubes and that the translated product remains at the sites to which it is transported, resulting in attenuation of GA responses by reducing the expression of many genes. The induction of semi-dwarfism in an apple cultivar on root stock harbouring Atgai suggests that long-distance transport of mRNA from grafts would be applicable to horticulture crops.

  1. Long-distance transport of Gibberellic Acid Insensitive mRNA in Nicotiana benthamiana

    PubMed Central

    2013-01-01

    Background The Gibberellic Acid (GA) signal is governed by the GAI (Gibberellic Acid Insensitive) repressor, which is characterized by a highly conserved N-terminal DELLA domain. Deletion of the DELLA domain results in constitutive suppression of GA signaling. As the GAI transcript is transportable in phloem elements, a Δ-DELLA GAI (gai) transgenic stock plant can reduce the stature of a scion through transport of gai mRNA from the stock. However, little is known about the characteristics of a scion on a gai stock. Results Arabidopsis Δ-DELLA GAI (gai) was fused with a T7 epitope tag and expressed under the control of a companion cell-specific expression promoter, Commelina yellow mottle virus promoter (CoYMVp), to enhance transport in the phloem. The CoYMVp:Atgai-T7 (CgT) transgenic Nicotiana benthamiana exhibited a dwarf phenotype and lower sensitivity to GA enhancement of shoot stature. A wild-type (WT) scion on a CgT stock contained both Atgai-T7 mRNA and the translated product. Microarray analysis to clarify the effect of the CgT stock on the gene expression pattern in the scion clearly revealed that the WT scions on CgT stocks had fewer genes whose expression was altered in response to GA treatment. An apple rootstock variety, Malus prunifolia, integrating CoYMVp:Atgai moderately reduced the tree height of the apple cultivar scion. Conclusions Our results demonstrate that Atgai mRNA can move from companion cells to sieve tubes and that the translated product remains at the sites to which it is transported, resulting in attenuation of GA responses by reducing the expression of many genes. The induction of semi-dwarfism in an apple cultivar on root stock harbouring Atgai suggests that long-distance transport of mRNA from grafts would be applicable to horticulture crops. PMID:24144190

  2. Abdominal compartment syndrome and open abdomen management with negative pressure devices.

    PubMed

    Surace, Alessandra; Ferrarese, Alessia; Marola, Silvia; Cumbo, Jacopo; Valentina, Gentile; Borello, Alessandro; Solej, Mario; Martino, Valter; Nano, Mario

    2015-01-01

    Per sindrome compartimentale addominale (SCA) si intende un incremento della pressione intra-addominale (PIA) a valori superiori a 20 mmHg, associato ad una ridotta perfusione e disfunzione d’organo. La mortalità della SCA è del 50%; la sua incidenza tra i pazienti in RIA è del 30-50%. Il trattamento chirurgico consiste sostanzialmente nella decompressione addominale con apertura dell’addome; attualmente la metodica più utilizzata per la gestione della SCA è la terapia a pressione negativa. Nel 2009 è stata realizzata una classificazione dell’addome aperto, che stratifica i pazienti in base alla cronologia naturale del miglioramento o del deterioramento clinico dei pazienti con addome aperto. Lo scopo del trattamento è mantenere l’addome aperto del paziente al livello più basso ed evitare la progressione ad un livello più complesso. Secondo quanto riportato in letteratura questa metodica consente un tasso di chiusura fasciale tra i 65 e il 100% dei casi, riduce i tassi di mortalità e i tempi di degenza nei reparti di terapia intensiva. La chiusura dell’addome può avvenire progressivamente (per ridurre il rischio di fascite) oppure mediante l’utilizzo di una protesi biologia spessa su cui viene posizionata una copertura in plastica e impostato il lavaggio nel sottocute: la parete addominale deve essere chiusa dopo 24 ore. Se non fosse possibile chiudere tutti gli strati della parete addominale, il tentativo deve riguardare almeno il peritoneo, per ridurre morbilità e mortalità.

  3. Coalition Information Interoperability (Interoperabilite d’informations de coalition)

    DTIC Science & Technology

    2008-12-01

    Wachtberg-Werthhoven e-mail: wunder@fgan.de ITALY LtCol. Angelo Messina Ministero Della Difesa Segretariato Generale e Direzione Nazionale...it possible to learn from other domains (e.g. biology, medicine, seismology ). Are ontology tools sufficiently mature to be useful? Useful tools...Defence – KHID/IRSD/RHID Management of Scientific & Technological Research ITALIE ROUMANIE for Defence, National RTO Coordinator General Secretariat

  4. Factors in Italian Military Modernization

    DTIC Science & Technology

    2005-06-17

    Italian public’s ambiguous support for the war in Iraq, threaten the relationship. President Bush and Prime Minister Berlusconi share a rare relationship...between US and European leaders. Their relationship is such that the Italian press considered Prime Minister Berlusconi a trusted communications...Verderami “Italy’s Berlusconi Unleashes Bid To Regain Lost Popularity, Foil Allies’ Coup,” Corriere della Sera, 26 November 2004 [article on-line

  5. Twelfth Annual Carmel Conference, "Distinctiveness and Memory: Cognitive Psychophysiological and Physiological Considerations"

    DTIC Science & Technology

    1993-06-10

    Champaign, IL 61820 Champaign, IL 61820 Gabriele Gratton Michael Coles Fidia Research Laboratories Depz tment of Psychology Via Ponte della Fabbrica 3...Recordings Gabriel , Gehring, Hampson, Hillyard. Polich, Snyder, Wilson, Wood This panel’s charge assumes that we have agreed that a small number of surface...to reduce the distance. I Charge to Panels .5- S Panel IV. Cognitive Neuroscience and Theories of Hippocampal Function Deadwyler, Gratton , Heffley

  6. [Giuseppe Saverio Poli: magnetic therapy in Palermo at the beginning of XIX cent].

    PubMed

    Mazzola, Roberto

    2011-01-01

    The article presents a not well known text written by Giuseppe Saverio Poli, one of the most important South italian scientist, living and working between the end of XVIII century and the first years of XIX century. The Breve saggio sulle virtù curative della calamita, printed in Palermo in 1811, is a short text devoted to one of the most controversial scientific topic of those years, magnetic therapy.

  7. Impact of thistle rennet from Carlina acanthifolia All. subsp. acanthifolia on bacterial diversity and dynamics of a specialty Italian raw ewes' milk cheese.

    PubMed

    Cardinali, Federica; Osimani, Andrea; Taccari, Manuela; Milanović, Vesna; Garofalo, Cristiana; Clementi, Francesca; Polverigiani, Serena; Zitti, Silvia; Raffaelli, Nadia; Mozzon, Massimo; Foligni, Roberta; Franciosi, Elena; Tuohy, Kieran; Aquilanti, Lucia

    2017-08-16

    Caciofiore della Sibilla is an Italian specialty soft cheese manufactured with Sopravissana raw ewes' milk and thistle rennet prepared with young fresh leaves and stems of Carlina acanthifolia All. subsp. acanthifolia, according to an ancient tradition deeply rooted in the territory of origin (mountainous hinterland of the Marche region, Central Italy). In this study, the impact of thistle rennet on the bacterial dynamics and diversity of Caciofiore della Sibilla cheese was investigated by applying a polyphasic approach based on culture and DNA-based techniques (Illumina sequencing and PCR-DGGE). A control cheese manufactured with the same batch of ewes' raw milk and commercial animal rennet was analyzed in parallel. Overall, a large number of bacterial taxa were identified, including spoilage, environmental and pro-technological bacteria, primarily ascribed to Lactobacillales. Thistle rennet was observed clearly to affect the early bacterial dynamics of Caciofiore della Sibilla cheese with Lactobacillus alimentarius/paralimentarius and Lactobacillus plantarum/paraplantarum/pentosus being detected in the phyllosphere of C. acanthifolia All., thistle rennet and curd obtained with thistle rennet. Other bacterial taxa, hypothetically originating from the vegetable coagulant (Enterococcus faecium, Lactobacillus brevis, Lactobacillus delbrueckii, Leuconostoc mesenteroides/pseudomesenteroides), were exclusively found in Caciofiore della Sibilla cheese by PCR-DGGE. At the end of the maturation period, Illumina sequencing demonstrated that both cheeses were dominated by Lactobacillales; however curd and cheese produced with thistle rennet were co-dominated by Lactobacillus and Leuconostoc, whereas Lactoccous prevailed in curd and cheese produced with commercial animal rennet followed by Lactobacillus. Differences in the bacterial composition between the two cheeses at the end of their maturation period were confirmed by PCR-DGGE analysis. Copyright © 2017 Elsevier B

  8. Optical follow-up of the gamma-ray flare from the FSRQ 3C 345

    NASA Astrophysics Data System (ADS)

    Berton, M.; Calcidese, P.; Chen, S.; Congiu, E.

    2017-06-01

    As a follow-up of the flaring activity of the flat-spectrum radio quasar 3C 345 (z = 0.5928, Lynds, C.R., et al., 1965, ApJ, 142, 1667) in gamma rays, we observed the source in optical with the 81cm telescope of the Osservatorio astronomico della Regione Autonoma Valle d'Aosta (Italy), and the 1.22m telescope of the Asiago Astrophysical Observatory (Italy).

  9. Selecting Multinomial Populations

    DTIC Science & Technology

    1990-01-01

    Shannon (1948). The Gini -Simpson index was introduced by Gini ( 1912 ) and Simpson (1949). Both are Schur-concave function of p. In the literature...generalized entropy goodness. Tamkang Journal of Mathematics, 12, 206-208. Gini , C. ( 1912 ). Variabilita e Mutabilit6. Studi Economico-aguridici della...fair multinomial population; entropy function; Gini -Simpson index; natural selection procedure; empirical Bayes selection procedure; asymptotically

  10. Selecting the Fairest of kappa (> or = 2) mu-Sided Dice

    DTIC Science & Technology

    1989-06-01

    Simpson index was introduced by Gini ( 1912 ) and Simpson (1949). Both these indices are Schur-concave functions of p. Gupta and Huang (1976) have...Tamkang Journal of Mathematics, 12, 206-208. Gini , C. ( 1912 ). Variabilita e Mutabiliti. Studi Economico-aguridici della facotta di Giurisprudegza dell...been commonly used. They are Shannon’s entropy and Gini -Simpson index. The notion of the entropy function was introduced by Shannon (1948). The Gini

  11. Squamous cell carcinoma arising on a forearm free flap 21 years after hemiglossectomy.

    PubMed

    Valentini, Valentino; Cassoni, Andrea; Terenzi, Valentina; Prucher, Gianmarco; Zadeh, Oriana Rajabtork; Bosco, Sandro; Belli, Evaristo

    2016-02-04

    Allo stato attuale i lembi liberi ed i peduncolati rappresentano l’opzione di scelta nella ricostruzione dei difetti del cavo orale derivanti dalla resezione di neoplasie maligne. In questi casi la mucosa viene ricostruita nella maggior parte dei casi dalla porzione cutanea del lembo di modo da garantire il rivestimento epiteliale. In rari casi è stata descritta l’insorgenza di tumori secondari a livello della suddetta porzione cutanea.

  12. Gibberellin Signaling Requires Chromatin Remodeler PICKLE to Promote Vegetative Growth and Phase Transitions1[OPEN

    PubMed Central

    Nguyen, Khoa Thi; Ogas, Joe; Choi, Giltsu

    2017-01-01

    PICKLE (PKL) is an ATP-dependent chromodomain-helicase-DNA-binding domain (CHD3) chromatin remodeling enzyme in Arabidopsis (Arabidopsis thaliana). Previous studies showed that PKL promotes embryonic-to-vegetative transition by inhibiting expression of seed-specific genes during seed germination. The pkl mutants display a low penetrance of the “pickle root” phenotype, with a thick and green primary root that retains embryonic characteristics. The penetrance of this pickle root phenotype in pkl is dramatically increased in gibberellin (GA)-deficient conditions. At adult stages, the pkl mutants are semidwarfs with delayed flowering time, which resemble reduced GA-signaling mutants. These findings suggest that PKL may play a positive role in regulating GA signaling. A recent biochemical analysis further showed that PKL and GA signaling repressors DELLAs antagonistically regulate hypocotyl cell elongation genes by direct protein-protein interaction. To elucidate further the role of PKL in GA signaling and plant development, we studied the genetic interaction between PKL and DELLAs using the hextuple mutant containing pkl and della pentuple (dP) mutations. Here, we show that PKL is required for most of GA-promoted developmental processes, including vegetative growth such as hypocotyl, leaf, and inflorescence stem elongation, and phase transitions such as juvenile-to-adult leaf and vegetative-to-reproductive phase. The removal of all DELLA functions (in the dP background) cannot rescue these phenotypes in pkl. RNA-sequencing analysis using the ga1 (a GA-deficient mutant), pkl, and the ga1 pkl double mutant further shows that expression of 80% of GA-responsive genes in seedlings is PKL dependent, including genes that function in cell elongation, cell division, and phase transitions. These results indicate that the CHD3 chromatin remodeler PKL is required for regulating gene expression during most of GA-regulated developmental processes. PMID:28057895

  13. Real-time elastography in the diagnosis of prostate tumor.

    PubMed

    Ferrari, F S; Scorzelli, A; Megliola, A; Drudi, F M; Trovarelli, S; Ponchietti, R

    2009-03-01

    Sommario SCOPO: Verificare il guadagno diagnostico dell'elastosonografia transrettale real-time (RTE) rispetto alla ecografia transrettale B-mode nel rilievo del tumore prostatico in una popolazione di pazienti con sospetto di neoplasia. MATERIALI E METODI: Ottantaquattro pazienti con sospetto clinico-laboratoristico di tumore prostatico sono stati valutati mediante ecografia transrettale, elastosonografia e biopsia transperineale. RISULTATI: L'esame bioptico è stato considerato lo standard di riferimento. Nella valutazione per paziente, la sensibilità dell'ecografia B-mode è stata del 56%; la specificità dell'80%; il valore predittivo positivo (VPP) del 70%, il valore predittivo negativo (VPN) del 67%. Nella valutazione sul totale dei prelievi bioptici la sensibilità è stata del 33%, la specificità del 92%, il VPP del 69%, il VPN del 73%. La RTE ha ottenuto i seguenti risultati nella valutazione per paziente: sensibilità 51%, specificità 75%, VPP 64% e VPN 64%. Nella valutazione sul totale dei prelievi bioptici: sensibilità 36%, specificità 93%, VPP 72%, VPN 74%. Confrontando i valori di accuratezza dell'ecografia B-mode e della RTE per i tumori della zona periferica, è stata trovata una differenza significativa. Nella valutazione sul totale dei prelievi bioptici della zona periferica la sensibilità dell'ecografia B-mode è stata del 48%, la specificità dell'81%, il VPP del 75%, il VPN del 58%. La RTE ha ottenuto i seguenti valori: sensibilità 66%, specificità 78%, VPP 77%, VPN 67%. CONCLUSIONI: La RTE rappresenta un valore aggiunto all'ecografia B-mode. Ha presentato un'accuratezza superiore rispetto all'esame B-mode nella valutazione della prostata periferica e nella possibilità di indirizzare i prelievi bioptici.

  14. Prolidase activity and oxidative stress in patients with breast carcinoma A prospective randomized case-controlled study.

    PubMed

    Bayhan, Zulfu; Zeren, Sezgin; Kocak, Cengiz; Kocak, Fatma Emel; Duzgun, Sukru Aydin; Algin, Mustafa Cem; Taskoylu, Burcu Yapar; Yaylak, Faik

    2016-09-19

    Lo stress ossidativo gioca un ruolo importante nella patogenesi delle malattie neoplastiche. La prolidasi è un costituente della matrice metalloproteinasica, gioca un ruolo maggiore nel metabolismo del collagene, nell’accrescimento cellulare e nel rimodellamento strutturale. Una elevata attività prolidasica è stata dimostrata in molti casi di carcinomi. Lo scopo del presente studio è quello di indagare sull’attività sierica della prolidasi, dello stato ossidativo (TOS) ed antiossidativo (TAS) totale, e di valutare il loro rapporto con lo stadio del tumore, delle metastasi linfonodali e della massa neoplastica in pazienti con carcinoma mammario. Per lo studio sono state arruolate 35 pazienti con carcinoma della mammella e 40 soggetti di controllo. Sono stati rilevati i livelli di TAS, TOS e dell’attività prolidasica, calcolando gli indici di stress ossidativo (OSI). Come risultato i livelli di TOS, di OSI e dell’attività prolidasica sono risultati significativamente più elevati nelle pazienti con carcinoma mammario rispetto al gruppo di controllo (rispettivamente (P < 0.001, P < 0.001, P = 0.002). I livelli di TAS sono risultati significativamente inferiori nelle pazienti con carcinoma mammario rispetto al gruppo di controllo (P = 0,016). Sono stati rilevate correlazioni positive tra attività prolidasica, ed i livelli di TOS e di OSI con lo stadio tumorale, le metastasi linfoniodali e le dimensioni del tumore. Negativa è risultata la correlazione tra i livelli di TAS e le dimensioni del tunore, ma nessuna correlazione tra i livelli di TAS e lo stadio del tumore, come pure con l’infiltrazione linfonodale. Si conclude che l’elevata attività prolidasica del siero e lo stress ossidativo possono associarsi col carcinoma mammario. L’accresciuta attività prolidasica può essere messa in relazione con lo stadio e la prognosi del carcinoma mammario.

  15. Arabidopsis RGL1 Encodes a Negative Regulator of Gibberellin Responses

    PubMed Central

    Wen, Chi-Kuang; Chang, Caren

    2002-01-01

    In Arabidopsis, the DELLA subfamily of GRAS regulatory genes consists of GAI, RGA, RGA-LIKE1 (RGL1), RGL2, and RGL3. GAI and RGA are known to be negative regulators of gibberellin (GA) responses. We found that RGL1 is a similar repressor of GA responses, as revealed by RGL1 gain-of-function and loss-of-function phenotypes. Repression of GA responses in Arabidopsis was conferred by a dominant 35S-rgl1 transgene carrying a DELLA domain deletion analogous to the GA-insensitive gai-1 mutation. As in GA-deficient Arabidopsis, the transgenic plants were dark green dwarfs with underdeveloped trichomes and flowers. Expression levels of GA4, a feedback-regulated GA biosynthetic gene, were increased correspondingly. Conversely, a loss-of-function rgl1 line had reduced GA4 expression and exhibited GA-independent activation of seed germination, leaf expansion, flowering, stem elongation, and floral development, as detected by resistance to the GA biosynthesis inhibitor paclobutrazol. RGL1 plays a greater role in seed germination than do GAI and RGA. The expression profile of RGL1 differed from those of the four other DELLA homologs. RGL1 message levels were predominant in flowers, with transcripts detected in developing ovules and anthers. As with RGA, green fluorescent protein (GFP)–tagged RGL1 protein was localized to the nucleus, but unlike GFP-RGA, there was no degradation after GA treatment. These findings indicate that RGL1 is a partially redundant, but distinct, negative regulator of GA responses and suggest that all DELLA subfamily members might possess separate as well as overlapping roles in GA signaling. PMID:11826301

  16. Primary intra-abdominal synovial sarcoma: a case report.

    PubMed

    Travaglini, Grazia; Biagetti, Simona; Alfonsi, Simona; Bearzi, Italo; Marmorale, Cristina

    2013-09-03

    Il caso clinico che vi presentiamo riguarda la straordinaria localizzazione intra-addominale di un sinovial-sarcoma. Questo tumore dei tessuti molli generalmente interessa le piccole e grandi articolazioni. Sono state descritte altre localizzazioni a livello intra-addominale e retroperitoneale. La nostra paziente si ricovera per una tumefazione dolente dell’addome, alla TC addome si evidenzia una voluminosa massa intra-addominale che comprime e disloca i parenchimi e visceri circostanti e che affiora ai tessuti più superficiali della parete addominale. La biopsia eco-guidata della lesione, insieme allo studio immunoistochimico, permette di porre la diagnosi di sinovial-sarcoma. La paziente viene candidata ad un trattamento chemioterapico a scopo neoadiuvante. Per il sopraggiungere di anemizzazione da sanguinamento della neoplasia, valutata anche la risposta parziale al trattamento sistemico, si pone indicazione all’intervento chirurgico. La massa con peduncolo vascolare maggiore costituito dai vasi gastroepiploici di destra, viene completamente asportata. L’esame definitivo conferma la diagnosi di Sinovial-Sarcoma bifasico. L’indagine genetica condotta sul campione conservato in formalina non ha permesso, a causa della difficoltà di estrarre ed amplificare un quantitativo adeguato di RNA, di identificare la traslocazione (X; 18) (p 11.2; q 11.2) specifica del Sinovial-Sarcoma. La paziente è stata dimessa dopo un decorso clinico regolare. Il follow-up ad un anno non ha mostrato ripresa di malattia ma dopo 18 mesi alla TC torace-addome di rivalutazione si evidenzia la ripresa di malattia a livello intra-addominale e la presenza di metastasi polmonari bilaterali.

  17. Diffuse malignant biphasic peritoneal mesothelioma with cystic areas.

    PubMed

    Cabibi, Daniela; Tutino, Roberta; Salamone, Giuseppe; Cocorullo, Gianfranco; Agrusa, Antonino; Gulotta, Gaspare

    2016-06-20

    Il mesotelioma peritoneale maligno è una patologia rara la cui diagnosi è resa particolarmente difficile dalla molteplicità delle possibili presentazioni cliniche e morfologiche. A differenza della patologia pleurica, questa sembra avere una minore correlazione con l’esposizione all’asbesto. La prognosi è sfavorevole con una sopravvivenza media di 5.4 mesi. Riportiamo un caso di mesotelioma peritoneale in un paziente di 73 anni con esposizione professionale all’asbesto. La diagnosi è verosimilmente avvenuta dopo diversi inquadramenti clinici, che hanno compreso addominalgie attribuite ad IBD, poi non accertate istologicamente, e ad un’appendicite acuta. Per ultimo il paziente è giunto alla nostra osservazione con un quadro subocclusivo che l’indagine TC attribuiva ad una verosimile carcinosi peritoneale a primitivo sconosciuto. La laparoscopia esplorativa, poi convertita in approccio laparotomico, ha mostrato un quadro di peritonite incapsulante che coinvolgeva estesamente l’intestino tenue. È stata eseguita una resezione intestinale del tenue coinvolto ed una asportazione di un’area nodulare peri-splenica. L’esame istologico con l’integrazione di indagini immunoistochimiche ha permesso la diagnosi di mesotelioma peritoneale cistico maligno con istotipo bifasico che risulta essere il primo descritto in letteratura. Le aree cistiche avevano inizialmente fatto propendere per una diagnosi di mesotelioma multicistico benigno o di mesotelioma cistico con secondaria proliferazione miofibroblastica pseudosarcomatosa. Negli ultimi anni la prognosi di questa patologia ha trovato nell’utilizzo della chirurgia citoriduttiva e della chemioterapia intraperitoneale un miglioramento prognostico, queste nuove tecniche sono disponibili in centri di riferimento e trovano ad oggi indicazione solo in casi selezionati e in istotipi poco aggressivi. Il nostro paziente a causa dell’estensione della malattia, dell’istotipo non favorevole e dell

  18. Marussi Hypothesis in Differential Geodesy

    DTIC Science & Technology

    1994-06-13

    Geodesia e Scienze Affini, anno XXIV, 607-622 = 5-21 of Hotine (1991). M. Hotine (1966a) Triply orthogonal coordinate systems, Bulletin Gdoddsique 8&, 195...Bulletin Geodisique 14, 411-439. A. Marussi (1951) Fondamenti di geodesia intrinseca, Pubblicazioni della Commissione Geodetica Italiana, (Ser. III) 71, 1...Hotine’s (w, 0, N) coordinate system in differential geodesy, Bollettino di Geodesia e Scienze Affini, anno LIII, in press. J. Zund (1990a) An essay on

  19. A Mathematical Appreciation of Antonio Marussi’s Contributions to Geodesy

    DTIC Science & Technology

    1989-11-20

    founder (and for many years the director) of the Istituto di Geodesia e Geofisica at this university. 4 Marussi’s association with the I.G.M. gave him... Geodesia intrinseca, Annali Universita di Trieste, Serie IV, 19 (1949), 1-15. [5] A. MARUSSI, Fondements de g6ome-trie differentielle absolu du champ...7] A. MARUSSI, Fondementi di geodesia intrinseca, Pubblicazioni della Commissione Geodetica Italiana (Terza Serie) Memorie 7 (1951), 1-47

  20. Precision and Purpose: Airpower in the Libyan Civil War

    DTIC Science & Technology

    2015-01-01

    about the Spanish Ejército del Aire’s participation in OUP, see “Misión Cumplida en Libia,” Revista Española de Defensa, November 2011, pp. 6–11... Revista Española de Defensa, November 2011, pp. 6–11. “Missile libico sfiora nave italiana cade in mare: Nessun ferito né danni,” Corriere Della Sera.it

  1. Magnetostimulated Anisotropy of Conductivity and Corbino-Like Current in Composite Conductors

    DTIC Science & Technology

    2000-09-29

    Istituto Nazionale Fisica della Materia, Dipartimento di Matematica e Fisica, Universita di Camerino Via Madonna delle Carceri, 62032 Camerino, Italy Fax...case between two limit geometries of the single conductor on the one hand and disk conductor on the other hand. 1 . Introduction Pure aluminum is a...opposite polarities of Hall coefficients is discussed [ 1 , 2]. Composite components have the electric contact in the interface being orthogonal to an

  2. Plant hormones in arbuscular mycorrhizal symbioses: an emerging role for gibberellins

    PubMed Central

    Foo, Eloise; Ross, John J.; Jones, William T.; Reid, James B.

    2013-01-01

    Background and Aims Arbuscular mycorrhizal symbioses are important for nutrient acquisition in >80 % of terrestrial plants. Recently there have been major breakthroughs in understanding the signals that regulate colonization by the fungus, but the roles of the known plant hormones are still emerging. Here our understanding of the roles of abscisic acid, ethylene, auxin, strigolactones, salicylic acid and jasmonic acid is discussed, and the roles of gibberellins and brassinosteroids examined. Methods Pea mutants deficient in gibberellins, DELLA proteins and brassinosteroids are used to determine whether fungal colonization is altered by the level of these hormones or signalling compounds. Expression of genes activated during mycorrhizal colonization is also monitored. Key Results Arbuscular mycorrhizal colonization of pea roots is substantially increased in gibberellin-deficient na-1 mutants compared with wild-type plants. This is reversed by application of GA3. Mutant la cry-s, which lacks gibberellin signalling DELLA proteins, shows reduced colonization. These changes were parallelled by changes in the expression of genes associated with mycorrhizal colonization. The brassinosteroid-deficient lkb mutant showed no change in colonization. Conclusions Biologically active gibberellins suppress arbuscule formation in pea roots, and DELLA proteins are essential for this response, indicating that this role occurs within the root cells. PMID:23508650

  3. Elettrodinamica classica

    NASA Astrophysics Data System (ADS)

    Lechner, Kurt

    Nella scoperta della Relatività Ristretta l'Elettrodinamica, rappresentando una teoria relativistica per eccellenza, ha giocato un ruolo fondamentale. Il principio di relativit` a einsteiniana, che afferma che tutte le leggi della fisica devono avere la stessa forma in tutti i sistemi di riferimento inerziali, è emerso con forza da questa teoria ed è andato consolidandosi sempre di più, man mano che le nostre conoscenze del mondo microscopico sono diventate più complete: tutte le interazioni fondamentali rispettano infatti tale principio. Il modo più semplice ed elegante per implementarlo — difatti l'unico di un'utilità concreta — è rappresentato dal paradigma della covarianza a vista nell'ambito del calcolo tensoriale. Questo paradigma è stato applicato con successo a tutte le teorie di carattere fondamentale, come le teorie che descrivono le quattro interazioni fondamentali e le più speculative teorie di superstringa, e mantiene la sua piena efficacia anche in teoria quantistica. La nostra esposizione dell'Elettrodinamica classica si baserà dunque a ragione su questo paradigma.

  4. The role of plastic surgeon in complex cephalic malformations. Our experience.

    PubMed

    Chiumariello, Stefano; Del Torto, Giuseppe; Guarro, Giuseppe; Alfano, Carmine

    2014-01-01

    Le malformazioni complesse del distretto cefalico comprendono tutta una serie di anomalie di sviluppo che oltre a presentare una notevole difficoltà classificativa e di inquadramento, comprendono forme che sono talora di stretta pertinenza specialistica. La correzione delle malformazioni craniofacciali fa ricorso ad una disciplina chirurgica particolarmente esigente, che deve associare una formazione chirurgica di base con un apprendimento delle tecniche specifiche per il territorio craniofacciale e una conoscenza della patologia malformativa. L’eziologia malformativa pone il chirurgo davanti a problemi specifici, dominati dallo sviluppo della tecnica chirurgica. Si stabilisce dunque un protocollo terapeutico dopo aver identificato la malformazione, stimato la gravità delle alterazioni tissutali e valutato la capacità di crescita dei territori interessati. E’ fondamentale, oltre che il rimodellamento della morfologia, il recupero delle funzioni ed il trattamento rieducativo. E’ quindi evidente che si tratta di una chirurgia di equipe che può portare risultati positivi solo se realizzata con fiducia reciproca tra i vari operatori.

  5. Innovative technique for large septal perforation repair and radiological evaluation.

    PubMed

    Mocella, S; Muia, F; Giacomini, P G; Bertossi, D; Residori, E; Sgroi, S

    2013-06-01

    La perforazione del setto nasale ha cause molteplici: traumatiche, iatrogene, infettive, degenerative, da abuso di vasocostrittori, da uso di cocaina e di recente anche da chemioterapici antineoplastici. Le perforazioni sono altresì classificate in funzione delle dimensioni e della tipologia del deficit cartilagineo o osteocartilagineo e della sede anteriore, mediana e posteriore. Molteplici tecniche di riparazione chirurgica del danno sono state proposte nel tempo e vengono riassunte nel presente lavoro per tipologia di approccio; i risultati conseguiti, sono soddisfacenti per le perforazioni di piccole e medie dimensioni, ma nelle grandi perforazioni non garantiscono sempre la permanente obliterazione del difetto. Spesso si rende necessario l'utilizzo di tessuti prelevati all'interno delle fosse nasali come i turbinati o il prelievo di cartilagine da altre sedi donatrici come l'orecchio o la costa; le varie tecniche vengono illustrate alla luce della più recente letteratura. Gli Autori hanno valutato i pazienti osservati negli ultimi 8 anni e i risultati chirurgici conseguiti in particolare considerando, gli approcci chirurgici effettuati in approccio aperto o chiuso, endoscopico ed i materiali impiegati. Gli autori propongono tra le varie tecniche impiegate in questa serie di pazienti, una tecnica innovativa utilizzabile con successo in molti dei casi considerati di perforazione settale iatrogena che prevede l'utilizzo del gibbo osteocartilagineo quale sede donatrice, nonché la rinosettoplastica riduttiva quale scelta mirata per ottenere agevolmente lembi di scorrimento mucopericondrale e talora produrre anche un miglioramento estetico morfologico.

  6. Autotransplantation of pancreatic islets. A single-center first experience.

    PubMed

    Magistri, Paolo; Andreani, Sara; Lo Conte, Domenico; Ferrari, Giovanni Carlo; Forgione, Antonello; Pugliese, Raffaele

    2016-01-01

    L’autotrapianto d’isole pancreatiche (IAT) è una procedura ben nota che consente di migliorare il controllo glicemico dopo una pancreasectomia totale (o completamento di pancreasectomia dopo duodenocefalopancreasectomia) rispetto alla sola terapia insulinica. In questo lavoro presentiamo la nostra esperienza nel campo dell’ IAT riportando il caso clinico di una donna di sessanta anni, sottoposta a completamento di pancreasectomia per episodi ricorrenti di acuzie in un quadro di pancreatite cronica. Il trattamento IAT è stato somministrato mediante iniezione trans-epatica intra-portale. Il recupero post-procedurale è stato ottimale, fatta eccezione per un’infezione di ferita che ha richiesto un trattamento con tecnologia a pressione negativa. La paziente è stata dimessa in ventisettesima giornata postoperatoria, in buone condizioni generali, dopo regolare ripresa dell’alimentazione e della canalizzazione. I dati presenti in letteratura dimostrano che la IAT è una procedura sicura, garantendo nel lungo periodo un vantaggio rispetto alla terapia insulinica in termini di rapporto costo-beneficio. Riguardo alla procedura chirurgica, è qui utile ricordare che la mortalità a 30 giorni dopo pancreasectomia totale associata a IAT è del 5%, ed è pertanto sovrapponibile ai risultati della pancreasectomia totale senza IAT. Riportando questa esperienza intendiamo contribuire alla crescita della casistica chirurgica attuale in questo campo, proponendo nel futuro un più ampio sviluppo e una più estesa applicazione di tale approccio.

  7. Flower opening and closure: an update.

    PubMed

    van Doorn, Wouter G; Kamdee, Chanattika

    2014-11-01

    This review is an update of a 2003 review (Journal of Experimental Botany 54,1801-1812) by the same corresponding author. Many examples of flower opening have been recorded using time-lapse photography, showing its velocity and the required elongation growth. Ethylene regulates flower opening, together with at least gibberellins and auxin. Ethylene and gibberellic acid often promote and inhibit, respectively, the expression of DELLA genes and the stability of DELLA proteins. DELLA results in growth inhibition. Both hormones also inhibited and promoted, respectively, the expression of aquaporin genes required for cell elongation. Arabidopsis miRNA319a mutants exhibited narrow and short petals, whereby miRNA319a indirectly regulates auxin effects. Flower opening in roses was controlled by a NAC transcription factor, acting through miRNA164. The regulatory role of light and temperature, in interaction with the circadian clock, has been further elucidated. The end of the life span in many flowers is determined by floral closure. In some species pollination resulted in earlier closure of turgid flowers, compared with unpollinated flowers. It is hypothesized that this pollination-induced effect is only found in flowers in which closure is regulated by ethylene. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  8. Contralateral botulinum injections in patients with residual facial asymmetry and contralateral hyperkinesis after primary facial palsy surgery.

    PubMed

    Bartoli, Davina; Battisti, Andrea; Cassoni, Andrea; Terenzi, Valentina; Della Monaca, Marco; Pagnoni, Mario; Valentini, Valentino; Priore, Paolo

    2015-01-01

    Ogni trattamento, medico e chirurgico, della paralisi facciale è finalizzato al recupero della simmetria facciale statica e dinamica. La tossina botulinica di tipo A può essere utilizzata nei pazienti affetti da paralisi del nervo facciale, sottoposti in precedenza a chirurgia primaria, al fine di ridurre la residua asimmetria facciale e le progressive ipercinesie controlaterali al lato affetto, che caratterizzano tali soggetti. Sono stati inclusi nel nostro studio sei pazienti (1 maschio e 5 femmine) affetti da paralisi del nervo facciale monolaterale secondaria a diverse cause, classificata secondo la scala di House-Brackmann in grado III e IV. I pazienti inclusi nello studio sono stati sottoposti in precedenza a trattamento chirurgico riabilitativo specifico per la paralisi facciale stessa; successivamente ciascuno di essi è stato trattato con 50 unità di tossina botulinica di tipo A a livello del lato non affetto del volto, al fine di ridurre le ipercinesie muscolari ed aumentare l’asimmetria e l’abilità muscolare del volto. L’età media dei soggetti era di 44,5 anni. I pazienti sono stati esaminati a 7, 14, 30, 60, 90 e 120 giorni dopo il trattamento con tossina botulinica. Lo studio dimostra la riduzione delle ipercinesie controlaterali alla paralisi facciale ed il miglioramento della simmetria del volto nei pazienti sottoposti precedentemente a trattamento chirurgico primario per la riabilitazione del nervo facciale stesso. Tutti i pazienti si sono dimostrati soddisfatti del trattamento con tossina botulinica di tipo A.

  9. Three-port colectomy: reduced port laparoscopy for general surgeons. A single center experience.

    PubMed

    Cocorullo, Gianfranco; Tutino, Roberta; Falco, Nicolò; Salamone, Giuseppe; Gulotta, Gaspare

    Le resezioni coliche laparoscopiche sia per patologie benigne che maligne sono state investigate da importanti RCT che ne hanno dimostrato la sovrapponibilità alla tecnica open convenzionale. La laparoscopia con un numero ridotto di trocar ha da quel momento trovato ampio sviluppo nell’ottica di massimizzare i benefici della mini-invasività. Proponiamo un’analisi dei nostri risultati nell’utilizzo della tecnica three-port nella emicolectomia sinistra attraverso un confronto con la classica resezione laparoscopica con quattro/ cinque accessi. Come è noto i laparoceli si sviluppano maggiormente su incisioni mediane mentre non vi è differenza tra lo sviluppo di questi dopo tecnica open o laparoscopica. Nell’ottica della chirurgia a numero ridotto di accessi, la tecnica single-port sembra dare vantaggi di minor traumatismo ma ciò a costo di aumentate difficoltà di esecuzione, aumento dei tempi operatori e dell’utilizzo di strumenti per lo più dedicati, con incisioni ombelicali che possono superare i 5 cm. Le resezioni coliche three port consentono di ridurre il numero di accessi e dunque delle complicanze a questi correlate con l’utilizzo di strumentazione standard e la possibilità di esecuzione su larga scala da parte di ogni chirurgo. L’analisi che abbiamo eseguito ha dimostrato nella nostra serie una riduzione dei tempi operatori nella tecnica three port e ciò può essere dovuto all’inserimento dei trocar addizionali ed al loro controllo ma soprattutto alla possibilità/ necessità del chirurgo esperto di essere meno influenzato da fattori quali una equipe non dedicata. Non sono stati evidenziati vantaggi nella riduzione della degenza operatoria. Il tasso di conversione è stato maggiore nella tecnica a ridotto numero di accessi, questo è possibile sia un bias legato alle conversioni precoci prima del posizionamento di restanti trocar in casi particolarmente complessi. In conclusione, la tecnica three port appare comparabile alla

  10. Late surgical complications of subtotal colectomy with antiperistaltic caeco-rectal anastomosis for slow transit constipation A critical analysis.

    PubMed

    Marchesi, Federico; Rapacchi, Chiara; Cecchini, Stefano; Sarli, Leopoldo; Tartamella, Francesco; Roncoroni, Luigi

    2016-01-01

    La stipsi grave da rallentato transito è stata negli ultimi anni definitivamente riconosciuta come una condizione potenzialmente chirurgica, e nuove varianti tecniche sono state proposte in alternativa alla colectomia totale con ileo-retto anastomosi con l’obiettivo di minimizzare il rapporto rischi-benefici per il paziente. In quest’ottica la colectomia subtotale con anastomosi ceco-rettale (SCCRA) rappresenta nella nostra esperienza una valida alternativa, riducendo, a parità di efficacia, l’incontinenza e l’urgency postoperatoria, grazie alla preservazione della valvola ileo-cecale e del reservoir cecale. Tuttavia, a fronte di una buona percentuale di successi, legati soprattutto al miglioramento della selezione dei pazienti, la chirurgia della stipsi da rallentato transito presenta tuttora un non trascurabile numero di insuccessi e di complicanze tardive, spesso imprevedibili, e correlate alle varianti tecniche adottate. Nello specifico caso della SCCRA, la preservazione di un segmento colico verosimilmente malfunzionante (il ceco) è stata imputata come possibile causa di recidiva di stipsi cosiccome origine di complicanze chirurgiche tardive (distensione cecale, volvolo). L’obiettivo di questo studio è di analizzare in maniera critica le complicanze tardive di SCCRA, esaminando i rischi specifici della procedura per identificare possibili misure di prevenzione. A tal fine sono stati valutati i dati di 43 pazienti aderenti al follow-up sottoposti a SCCRA presso il nostro Istituto. Sono stati inclusi i pazienti sottoposti a re-intervento per complicanza tardiva chiaramente correlata a SCCRA presso il nostro centro. Sono state identificate 3 complicanze tardive (7%): una distensione cecale, un volvolo ileo-cecale, un volvolo ileale. Tutti i pazienti sono stati trattati chirurgicamente con successo. Solo nel primo caso è stata identificata una evidente condizione predisponente: la presenza di una defecazione ostruita non risolta associata ad un

  11. Recent developments in human biomonitoring: non-invasive assessment of target tissue dose and effects of pneumotoxic metals

    PubMed Central

    Mutti, A.; Corradi, M.

    2006-01-01

    Summary Tobacco smoke and polluted environments substantially increase the lung burden of pneumotoxic chemicals, particularly pneumotoxic metallic elements. To achieve a better understanding of the early events between exposure to inhaled toxicants and the onset of adverse effects on the lung, the characterization of dose at the target organ would be extremely useful. Exhaled breath condensate (EBC), obtained by cooling exhaled air under conditions of spontaneous breathing, is a novel technique that could provide a non-invasive assessment of pulmonary pathobiology. Considering that EBC is water practically free of interfering solutes, it represents an ideal biological matrix for elemental characterization. Published data show that several toxic metals and trace elements are detectable in EBC, raising the possibility of using this medium to quantify the lung tissue dose of pneumotoxic substances. This novel approach may represent a significant advance over the analysis of alternative media (blood, serum, urine, hair), which are not as reliable (owing to interfering substances in the complex matrix) and reflect systemic rather than lung (target tissue) levels of both toxic metals and essential trace elements. Data obtained among workers occupationally exposed to either hard metals or chromium (VI) and in smokers with or without chronic obstructive pulmonary disease (COPD) are reviewed to show that – together with biomarkers of exposure – EBC also allows the simultaneous quantification of biomarkers of effect directly sampled from the epithelial lining fluid, thus providing novel insights on both kinetic and dynamic aspects of metal toxicology. Riassunto «Recenti sviluppi nel biomonitoraggio umano: valutazione non invasiva della dose a livello dell’organo bersaglio e degli effetti pneumotossici». L’esposizione cronica a fumo di tabacco ed ad altri inquinati ambientali determina un accumulo polmonare di sostanze pneumotossiche, soprattutto metalli. Allo scopo

  12. A GRAS-like gene of sunflower (Helianthus annuus L.) alters the gibberellin content and axillary meristem outgrowth in transgenic Arabidopsis plants.

    PubMed

    Fambrini, M; Mariotti, L; Parlanti, S; Salvini, M; Pugliesi, C

    2015-11-01

    The GRAS proteins belong to a plant transcriptional regulator family that function in the regulation of plant growth and development. Despite their important roles, in sunflower only one GRAS gene (HaDella1) with the DELLA domain has been reported. Here, we provide a functional characterisation of a GRAS-like gene from Helianthus annuus (Ha-GRASL) lacking the DELLA motif. The Ha-GRASL gene contains an intronless open reading frame of 1,743 bp encoding 580 amino acids. Conserved motifs in the GRAS domain are detected, including VHIID, PFYRE, SAW and two LHR motifs. Within the VHII motif, the P-H-N-D-Q-L residues are entirely maintained. Phylogenetic analysis reveals that Ha-GRASL belongs to the SCARECROW LIKE4/7 (SCL4/7) subfamily of the GRAS consensus tree. Accumulation of Ha-GRASL mRNA at the adaxial boundaries from P6/P7 leaf primordia suggests a role of Ha-GRASL in the initiation of median and basal axillary meristems (AMs) of sunflower. When Ha-GRASL is over-expressed in Arabidopsis wild-type plants, the number of lateral bolts increases differently from untransformed plants. However, Ha-GRASL slightly affects the lateral suppressor (las-4-) mutation. Therefore, we hypothesise that Ha-GRASL and LAS are not functionally equivalent. The over-expression of Ha-GRASL reduces metabolic flow of gibberellins (GAs) in Arabidopsis and this modification could be relevant in AM development. Phylogenetic analysis includes LAS and SCL4/7 in the same major clade, suggesting a more recent separation of these genes with respect to other GRAS members. We propose that some features of their ancestor, as well as AM initiation and outgrowth, are partially retained in both LAS and SCL4/7.

  13. Multilevel brown tumors of the spine in a patient with severe secondary hyperparathyroidism A case report and review of the literature.

    PubMed

    Salamone, Daniela; Muresan, Simona; Muresan, Mircea; Neagoe, Radu

    2016-03-31

    Il tumore bruno è una forma estrema dell’osteite fibroso- cistica, che rappresenta una complicazione grave della forma avanzata di iperparatitroidismo primitivo o secondario. Può indorgere nel caso che si sviluppino elevati livelli di paratormone, come si verifica nell’iperparatiroidismo primitivo e secondario con una frequenza rispettivamente del 3-4% e del 1,5-13% , e colpisce per lo più l’età giovanile. Gli Autori presentano il caso di una donna di 45 anni in trattamento dialitico da molto tempo, che presentava un iperparatiroidismo grave. I principali sintomi clinici erano rappresentati da dolori cervicali, dolori al tratto toraco-lombare dorsale, e debolezza ad entrambi gli arti inferiori. La TC ha messo in evidenza la presenza di tumori bruni a livello delle vertebre cervicali, toraciche e lombari. Dopo un parziale successo al trattamento per due anni con Cinacalcet si è verificato un deterioramento dell’iperparatiroidismo secondario (ipercalcemia ed iperfosfatemia) ed è stata indicata ed eseguita la paratidoidectomia con autotrapianto, cui ha fatto seguito un risultato postoperatorio positivo. In conclusione l’iperparatiroidismo secondario può comportare lo sviluppo di lesioni osteolitiche ossee indicate come “tumori bruni”. Se il trattamento medico fallisce, l’unico rimedio alla progressione della patologia è rappresentato dalla paratiroidectomia con autotrapianto. Dopo revisione della abbondante letteratura in lingua Inglese (fino a marzo 2015) si rilevano 24 casi di tumori bruni sintomatici a livello vertebrale. A conoscenza degli Autori questo è il primo caso che descrive una diffusione vertebrale a più livelli, ed il primo che segnala una localizzazione al tratto vertebrale cervicale.

  14. [Valutazione del carico gestionale in un centro diurno psichiatrico: gravosità e recovery style].

    PubMed

    Callegari, Camilla; Caselli, Ivano; Bertù, Lorenza; Berto, Emanuela; Vender, Simone

    2016-01-01

    RIASSUNTO. Scopo. Nella riabilitazione psichiatrica il piano di trattamento individuale può essere formulato a partire da strumenti che offrano una valutazione multidimensionale del paziente. Il lavoro si propone di analizzare il rapporto tra gravosità (distress degli operatori) e stile di recupero (integration e sealing over) dalla patologia psicotica. Ipotizzando che esso influenzi il carico gestionale, lo studio si pone l'ulteriore obiettivo di acquisire maggiori elementi che indirizzino la formulazione di piani terapeutico-riabilitativi più efficaci. Metodi. Lo studio è stato condotto presso un centro diurno psichiatrico, struttura semi-residenziale dei servizi psichiatrici del Sistema Sanitario Nazionale in Italia. 45 pazienti reclutati sono stati valutati mediante la Neuropsychiatric Inventory (NPI - versione italiana) e la Integration/Sealing Over Scale (ISOS - versione italiana), nell'arco di tre mesi (marzo-giugno 2014). Risultati. Nel campione esaminato è emerso che la disinibizione, l'irritabilità e l'apatia sono i sintomi che provocano maggiore distress negli operatori, in senso assoluto. Inoltre, i risultati indicano che depressione e ansia recano un grado maggiore di distress nei pazienti sealer. Discussione e conclusione. Gli aspetti della disinibizione, dell'irritabilità e dell'apatia sono risultati più gravosi per gli operatori in quanto richiedono maggiore coinvolgimento nella relazione terapeutica. Sintomi ansiosi e depressivi risultano più gravosi nel gruppo dei sealer, segnalando minore tenuta della negazione della psicosi. I dati osservati sembrano provare che conoscere, differenziare e approfondire i diversi aspetti dello stile di recupero di ciascun paziente consente di stimare l'impegno gestionale fin dalla presa in carico e di ridurre il distress e il rischio di burnout degli operatori.

  15. Ultrasound in developmental dysplasia of the hip: A screening study in Sardinian newborns.

    PubMed

    Dessì, A; Crisafulli, M; Vannelli, E; Fanos, V

    2009-06-01

    Sommario INTRODUZIONE: La displasia evolutiva dell'anca (DDH) costituisce la deformità più frequente dell'apparato locomotore. Lo screening ecografico è la metodica più utilizzata nell'identificazione della DDH, considerando la brevità del periodo in cui la diagnosi è possibile prima della comparsa dei sintomi clinici. Un intervento terapeutico appropriato precoce può avere un effetto positivo in relazione all'evoluzione di tale patologia. METODI: L'esame ecografico, la sua valutazione, la classificazione e la tipizzazione delle anche sono stati effettuati secondo il metodo descritto dal Graf. I pazienti sono stati valutati per mezzo di un'analisi retrospettiva volta a identificare i casi di DDH. Tutti i casi sono stati classificati e in base a ciò si è deciso il tipo di trattamento da attuare. RISULTATI: Complessivamente sono state osservate 145 anche in 122 bambini che presentavano un certo grado di displasia. L'età alla diagnosi variava da 14 a 90 giorni con una media di 52 giorni di vita. Un mese dopo la diagnosi ecografica le anche di tipo 2a, sia bilaterali che unilaterali, sono risultate normali nel 94%. Il restante 6% così come i tipi 2b, 2c, D e 3 sono stati trattati con un divaricatore e la guarigione completa è stata ottenuta dopo due mesi di trattamento. Il tipo 4 è stato monitorato esclusivamente da un chirurgo ortopedico per un trattamento specialistico. CONCLUSIONI: Una volta effettuata l'indagine ecografica da operatori esperti si può decidere il tipo di trattamento più adeguato. L'ottima prognosi osservata a seguito del trattamento iniziale della DDH sottolinea la necessità di eseguire uno screening dell'anca allo scopo di effettuare una diagnosi e un trattamento precoce in questa patologia.

  16. Molecular Characterization of Rht-1 Dwarfing Genes in Hexaploid Wheat12[C][W][OA

    PubMed Central

    Pearce, Stephen; Saville, Robert; Vaughan, Simon P.; Chandler, Peter M.; Wilhelm, Edward P.; Sparks, Caroline A.; Al-Kaff, Nadia; Korolev, Andrey; Boulton, Margaret I.; Phillips, Andrew L.; Hedden, Peter; Nicholson, Paul; Thomas, Stephen G.

    2011-01-01

    The introduction of the Reduced height (Rht)-B1b and Rht-D1b semidwarfing genes led to impressive increases in wheat (Triticum aestivum) yields during the Green Revolution. The reduction in stem elongation in varieties containing these alleles is caused by a limited response to the phytohormone gibberellin (GA), resulting in improved resistance to stem lodging and yield benefits through an increase in grain number. Rht-B1 and Rht-D1 encode DELLA proteins, which act to repress GA-responsive growth, and their mutant alleles Rht-B1b and Rht-D1b are thought to confer dwarfism by producing more active forms of these growth repressors. While no semidwarfing alleles of Rht-A1 have been identified, we show that this gene is expressed at comparable levels to the other homeologs and represents a potential target for producing novel dwarfing alleles. In this study, we have characterized additional dwarfing mutations in Rht-B1 and Rht-D1. We show that the severe dwarfism conferred by Rht-B1c is caused by an intragenic insertion, which results in an in-frame 90-bp insertion in the transcript and a predicted 30-amino acid insertion within the highly conserved amino-terminal DELLA domain. In contrast, the extreme dwarfism of Rht-D1c is due to overexpression of the semidwarfing Rht-D1b allele, caused by an increase in gene copy number. We show also that the semidwarfing alleles Rht-B1d and Rht-B1e introduce premature stop codons within the amino-terminal coding region. Yeast two-hybrid assays indicate that these newly characterized mutations in Rht-B1 and Rht-D1 confer “GA-insensitive” dwarfism by producing DELLA proteins that do not bind the GA receptor GA INSENSITIVE DWARF1, potentially compromising their targeted degradation. PMID:22013218

  17. Laparoscopic resection of tailgut cysts: the size is not the issue.

    PubMed

    Dalmonte, Giorgio; Tartamella, Francesco; Mita, Maria Teresa; De Sario, Giuseppina; Roncoroni, Luigi; Marchesi, Federico

    2016-11-03

    Gli amartomi cistici retrorettali (Tailgut cysts) sono rare lesioni dello spazio presacrale che avendo rischio intrinseco di trasformazione maligna e recidiva sono normalmente trattate mediante asportazione chirurgica anche nel caso in cui siano asintomatiche. Negli ultimi vent’anni si sta affermando il trattamento mediante accesso addominale laparoscopico per la sua migliore esposizione delle strutture della pelvi e la sua minore invasività. In questo caso clinico presentiamo il trattamento del più grande amartoma cistico retrorettale asportato laparoscopicamente fino ad ora riportato in letteratura. Essendo nella maggior parte dei casi asintomatici, la diagnosi degli amartomi cistici retrorettali è spesso incidentale durante una visita medica di routine. Nel successivo studio è particolarmente indicata la RM per orientare la scelta dell’approccio chirurgico data la sua maggiore risoluzione nei tessuti molli e nella determinazione dell’invasività locale. La trasformazione maligna di queste lesioni si stima possa avvenire nel 14,1% dei casi, per questo l’exeresi chirurgica è la terapia di scelta. Tra i differenti approcci la tecnica transaddominale laparoscopica, se eseguita da chirurghi esperti nella chirurgia pelvica laparoscopica, garantisce la migliore visualizzazione degli organi pelvici e una minore morbidità. A causa del rischio di rottura e insemenzamento l’approccio laparoscopico non dovrebbe essere utilizzato in caso di sospetta malignità della lesione cistica. Il nostro caso corrobora la validità del trattamento laparoscopico degli amartomi cistici retrorettali, anche quando possiedono dimensioni considerevoli. Lo studio preo-peratorio è quindi cruciale per determinare la possibile malignità della lesione ed eseguire in tal caso un approccio laparotomico.

  18. A Transcriptional Program for Arbuscule Degeneration during AM Symbiosis Is Regulated by MYB1.

    PubMed

    Floss, Daniela S; Gomez, S Karen; Park, Hee-Jin; MacLean, Allyson M; Müller, Lena M; Bhattarai, Kishor K; Lévesque-Tremblay, Veronique; Maldonado-Mendoza, Ignacio E; Harrison, Maria J

    2017-04-24

    During the endosymbiosis formed between plants and arbuscular mycorrhizal (AM) fungi, the root cortical cells are colonized by branched hyphae called arbuscules, which function in nutrient exchange with the plant [1]. Despite their positive function, arbuscules are ephemeral structures, and their development is followed by a degeneration phase, in which the arbuscule and surrounding periarbuscular membrane and matrix gradually disappear from the root cell [2, 3]. Currently, the root cell's role in this process and the underlying regulatory mechanisms are unknown. Here, by using a Medicago truncatula pt4 mutant in which arbuscules degenerate prematurely [4], we identified arbuscule degeneration-associated genes, of which 38% are predicted to encode secreted hydrolases, suggesting a role in disassembly of the arbuscule and interface. Through RNAi and analysis of an insertion mutant, we identified a symbiosis-specific MYB-like transcription factor (MYB1) that suppresses arbuscule degeneration in mtpt4. In myb1, expression of several degeneration-associated genes is reduced. Conversely, in roots constitutively overexpressing MYB1, expression of degeneration-associated genes is increased and subsequent development of symbiosis is impaired. MYB1-regulated gene expression is enhanced by DELLA proteins and is dependent on NSP1 [5], but not NSP2 [6]. Furthermore, MYB1 interacts with DELLA and NSP1. Our data identify a transcriptional program for arbuscule degeneration and reveal that its regulators include MYB1 in association with two transcriptional regulators, NSP1 and DELLA, both of which function in preceding phases of the symbiosis. We propose that the combinatorial use of transcription factors enables the sequential expression of transcriptional programs for arbuscule development and degeneration. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Arabidopsis NAC Transcription Factor JUNGBRUNNEN1 Exerts Conserved Control Over Gibberellin and Brassinosteroid Metabolism and Signaling Genes in Tomato

    PubMed Central

    Shahnejat-Bushehri, Sara; Allu, Annapurna D.; Mehterov, Nikolay; Thirumalaikumar, Venkatesh P.; Alseekh, Saleh; Fernie, Alisdair R.; Mueller-Roeber, Bernd; Balazadeh, Salma

    2017-01-01

    The Arabidopsis thaliana NAC transcription factor JUNGBRUNNEN1 (AtJUB1) regulates growth by directly repressing GA3ox1 and DWF4, two key genes involved in gibberellin (GA) and brassinosteroid (BR) biosynthesis, respectively, leading to GA and BR deficiency phenotypes. AtJUB1 also reduces the expression of PIF4, a bHLH transcription factor that positively controls cell elongation, while it stimulates the expression of DELLA genes, which are important repressors of growth. Here, we extend our previous findings by demonstrating that AtJUB1 induces similar GA and BR deficiency phenotypes and changes in gene expression when overexpressed in tomato (Solanum lycopersicum). Importantly, and in accordance with the growth phenotypes observed, AtJUB1 inhibits the expression of growth-supporting genes, namely the tomato orthologs of GA3ox1, DWF4 and PIF4, but activates the expression of DELLA orthologs, by directly binding to their promoters. Overexpression of AtJUB1 in tomato delays fruit ripening, which is accompanied by reduced expression of several ripening-related genes, and leads to an increase in the levels of various amino acids (mostly proline, β-alanine, and phenylalanine), γ-aminobutyric acid (GABA), and major organic acids including glutamic acid and aspartic acid. The fact that AtJUB1 exerts an inhibitory effect on the GA/BR biosynthesis and PIF4 genes but acts as a direct activator of DELLA genes in both, Arabidopsis and tomato, strongly supports the model that the molecular constituents of the JUNGBRUNNEN1 growth control module are considerably conserved across species. PMID:28326087

  20. Cotton WRKY1 Mediates the Plant Defense-to-Development Transition during Infection of Cotton by Verticillium dahliae by Activating JASMONATE ZIM-DOMAIN1 Expression1[C][W

    PubMed Central

    Li, Chao; He, Xin; Luo, Xiangyin; Xu, Li; Liu, Linlin; Min, Ling; Jin, Li; Zhu, Longfu; Zhang, Xianlong

    2014-01-01

    Plants have evolved an elaborate signaling network to ensure an appropriate level of immune response to meet the differing demands of developmental processes. Previous research has demonstrated that DELLA proteins physically interact with JASMONATE ZIM-DOMAIN1 (JAZ1) and dynamically regulate the interaction of the gibberellin (GA) and jasmonate (JA) signaling pathways. However, whether and how the JAZ1-DELLA regulatory node is regulated at the transcriptional level in plants under normal growth conditions or during pathogen infection is not known. Here, we demonstrate multiple functions of cotton (Gossypium barbadense) GbWRKY1 in the plant defense response and during development. Although GbWRKY1 expression is induced rapidly by methyl jasmonate and infection by Verticillium dahliae, our results show that GbWRKY1 is a negative regulator of the JA-mediated defense response and plant resistance to the pathogens Botrytis cinerea and V. dahliae. Under normal growth conditions, GbWRKY1-overexpressing lines displayed GA-associated phenotypes, including organ elongation and early flowering, coupled with the down-regulation of the putative targets of DELLA. We show that the GA-related phenotypes of GbWRKY1-overexpressing plants depend on the constitutive expression of Gossypium hirsutum GhJAZ1. We also show that GhJAZ1 can be transactivated by GbWRKY1 through TGAC core sequences, and the adjacent sequences of this binding site are essential for binding specificity and affinity to GbWRKY1, as revealed by dual-luciferase reporter assays and electrophoretic mobility shift assays. In summary, our data suggest that GbWRKY1 is a critical regulator mediating the plant defense-to-development transition during V. dahliae infection by activating JAZ1 expression. PMID:25301887

  1. [Empathy in the nurse practitioners of medical area].

    PubMed

    Facco, Simona; Cirio, Luigi; Galante, Jenni; Dimonte, Valerio

    2014-01-01

    Introduzione. Attualmente sono pochi gli studi che indagano la capacità empatica nella popolazione infermieristica. Obiettivo di questo studio è analizzare la capacità empatica degli infermieri che prestano servizio in area medica in relazione a genere, età, formazione e anzianità di servizio. Materiali e metodi. Lo studio è di tipo descrittivo-osservazionale, su un campione di 60 infermieri. Lo strumento utilizzato per la valutazione dell’empatia è la scala di valutazione JSPE (versione HP) costituita da 20 item, in cui gli intervistati indicano il loro accordo o disaccordo con una scala Likert a 7 punti. Il range di valori possibili è da 20 a 140: il punteggio più alto corrisponde a una maggiore capacità empatica. Il questionario ha dimostrato la validità e l'affidabilità della versione italiana del JSPE con un coefficiente alfa di Cronbach di 0,85. Il punteggio Il livello di significatività statistica accettato è pari a P ≤ 0,05. Risultati. La media della capacità empatica dei professionisti intervistati è risultata di 104/140. Dai dati analizzati, emerge che con l’aumentare degli anni di servizio alla professione si verifica una diminuzione dell’empatia così come il permanere nello stesso reparto provoca una diminuzione empatica. Inoltre è emersa una maggiore empatia degli infermieri della neurologia rispetto alla medicina generale. Conclusioni. Lo studio evidenzia come i professionisti abbiano necessità di incrementare la capacità empatica soprattutto col trascorrere degli anni di esercizio alla professione. Probabilmente come meccanismo di difesa, il professionista tende a proteggersi dal coinvolgimento emotivo, favorendo le attività di natura più tecnico-gestuale, piuttosto che relazionale.

  2. [Shared decision making: a scoping review].

    PubMed

    Guarinoni, Milena Giovanna; Dignani, Lucia; Motta, Paolo Carlo

    2016-01-01

    Scopo. L’obiettivo primario dello studio è implementare e utilizzare uno strumento validato per misurare il fenomeno delle dimissioni difficili, che possa supportare il personale infer- mieristico nella programmazione della dimissione del paziente ricoverato nei reparti di Geria- tria e Medicina. Gli obiettivi secondari sono: - Sperimentare l’utilizzo dell’indice di BRASS - Studiare le caratteristiche della popolazione a rischio di dimissione difficile Metodo. studio osservazionale prospettico per misurare il fenomeno delle dimissioni difficili attraverso l’implementazione dell’indice di BRASS nei reparti di Geriatria e Medicina dell’Ospedale di Rovigo Ulss 18, al fine di studiare le caratteristiche della popolazione a rischio di dimissione difficile. Risultati. In un campione di 165 pazienti il 42,4% (70) era rispettivamente a rischio alto e medio di dimissione difficile, mentre il 15,2% (25) era a basso rischio. La media dei punteggi BRASS era di 18,76. Il 37,6% dei pazienti ad alto rischio erano ricoverati in Geriatria, mentre in Medicina i pazienti si concentrano maggiormente nella classe medio rischio. Conclusioni. Lo studio ha permesso di misurare il fenomeno delle dimissioni difficili classi- ficando i pazienti nei gruppi di rischio. L’analisi delle dimissioni protette ha fatto emergere la congruenza tra punteggio BRASS e caratteristiche del campione. Lo strumento non richiede tempi di compilazione lunghi, è di supporto al processo decisionale dell’infermiere perché rileva la necessità di creare un percorso strutturato sulla dimissione del paziente, in modo sistematico e programmato, evitando la dispersione di informazioni importanti al fin di garantire la continuità assistenziale.

  3. Endogenous diterpenes derived from ent-kaurene, a common gibberellin precursor, regulate protonema differentiation of the moss Physcomitrella patens.

    PubMed

    Hayashi, Ken-ichiro; Horie, Keisuke; Hiwatashi, Yuji; Kawaide, Hiroshi; Yamaguchi, Shinjiro; Hanada, Atsushi; Nakashima, Tamotsu; Nakajima, Masatoshi; Mander, Lewis N; Yamane, Hisakazu; Hasebe, Mitsuyasu; Nozaki, Hiroshi

    2010-07-01

    Gibberellins (GAs) are a group of diterpene-type plant hormones biosynthesized from ent-kaurene via ent-kaurenoic acid. GAs are ubiquitously present in seed plants. The GA signal is perceived and transduced by the GID1 GA receptor/DELLA repressor pathway. The lycopod Selaginella moellendorffii biosynthesizes GA and has functional GID1-DELLA signaling components. In contrast, no GAs or functionally orthologous GID1-DELLA components have been found in the moss Physcomitrella patens. However, P. patens produces ent-kaurene, a common precursor for GAs, and possesses a functional ent-kaurene synthase, PpCPS/KS. To assess the biological role of ent-kaurene in P. patens, we generated a PpCPS/KS disruption mutant that does not accumulate ent-kaurene. Phenotypic analysis demonstrates that the mutant has a defect in the protonemal differentiation of the chloronemata to caulonemata. Gas chromatography-mass spectrometry analysis shows that P. patens produces ent-kaurenoic acid, an ent-kaurene metabolite in the GA biosynthesis pathway. The phenotypic defect of the disruptant was recovered by the application of ent-kaurene or ent-kaurenoic acid, suggesting that ent-kaurenoic acid, or a downstream metabolite, is involved in protonemal differentiation. Treatment with uniconazole, an inhibitor of ent-kaurene oxidase in GA biosynthesis, mimics the protonemal phenotypes of the PpCPS/KS mutant, which were also restored by ent-kaurenoic acid treatment. Interestingly, the GA(9) methyl ester, a fern antheridiogen, rescued the protonemal defect of the disruption mutant, while GA(3) and GA(4), both of which are active GAs in angiosperms, did not. Our results suggest that the moss P. patens utilizes a diterpene metabolite from ent-kaurene as an endogenous developmental regulator and provide insights into the evolution of GA functions in land plants.

  4. Rare extra-adrenal paraganglioma mimicking a painful Schwannoma: case report.

    PubMed

    Picchetto, Andrea; M Paganini, Alessandro; Balla, Andrea; Quaresima, Silvia; Cantisani, Vito; D'Ambrosio, Giancarlo; Lezoche, Emanuele

    2014-09-26

    I paragangliomi hanno un’incidenza annuale di circa 1/100000; essi originano dai tessuti cromaffini dei corpi di Zurckerkandl. In questo case report riportiamo il caso di un uomo di 53 anni, già trattato e seguito per un precedente limfoma di Hodkin che è stato sottoposta a RMN dell’addome per una lombalgia cronica che durava da due anni e che non riusciva ad alleviare con i FANS. La RMN ha rivelato un’incidentaloma: una massa in regione para-aortica, a livello della loggia surrenalica sinistra con le caratteristiche di una massa nodulare solida (29*25mm), che non sembrava originare direttamente dal surrene. Il pz ha inoltre eseguito un TC dell’addome che ha mostrato una massa localizzata di fronte al surrene di sinistra; il collega radiologo ha definito questa massa come un tumore maligno delle guaine nervose periferiche (Schwannoma) o come un linfonodo colliquato (essendo nota la patologia linfomatosa già descritta in anamnesi). Il paziente non riferiva cefalea, palpitazioni, picchi ipertensivi ne’ altri sintomi sistemici. Durante il suo ricovero, sono stati dosati i marker tumorali cromogranina e l’enolasi neurono-specifica che sono risultati essere rispettivamente 187.00 ng/mL and 7.7 ng/mL. La lombalgia è stata trattata inizialmente con Ketorolac, senza beneficio alcuno, quindi con Ketorolac più Tramadolo in pompa elastomerica, nuovamente senza beneficio per il paziente, infine con infusione continua di Morfina. Dato che l’esatta natura della neoformazione non era nota e che l’esecuzione di una biopsia TC guidata non era tecnicamente possibile, è stata eseguita un’escissione per via laparoscopica della massa, con approccio anteriore submesocolico trans peritoneale, così come gli Autori sono soliti eseguire per la surrenalectomia sinistra. Sin dai primi giorni postoperatori il paziente non ha più necessitato della morfina. Il decorso postoperatorio è stato del tutto regolare. L’esame istologico è risultato essere paraganglioma. I

  5. Three-Dimensional Properties of Coronal Mass Ejections from STEREO/SECCHI Observations

    DTIC Science & Technology

    2012-01-01

    astro.physik.uni-goettingen.de V. Bothmer e-mail: bothmer@astro.physik.uni-goettingen.de G. Nisticò Dipartimento di Fisica , Universita della Calabria...and monthly smoothed sunspot numbers show generally similar trends but not detailed correlations as has been reported in earlier studies (e.g., St. Cyr...summarized in Table 2. The synthetic coronagraphic images generated with a ray-tracing code are shown in Fig- ure 5. The ray-tracing code allows us to

  6. "Miracolo dell'arte" Chi ha inventato il telescopio?

    NASA Astrophysics Data System (ADS)

    Sodi, Francesca

    2006-02-01

    Who did invent the telescope? It seems a simple-answering question but this is untrue. The article recall the fundamental steps of the first phase in the telescope history between 16th and 17th century, from the first experiences with the lenses made by the Italian opticians to the Della Porta's theories, from the vicissitudes of the Dutch spectacle-makers to the spreading of the new instrument through the European squares. At last we meet the work of Galileo Galilei, the first man to use the telescope for scientific purposes, understanding all its potentialities.

  7. Cutaneous metastasis from lung cancer. Case report.

    PubMed

    Fratus, Giorgio; Tagliabue, Fabio; Mariani, Pierpaolo; Bottazzi, Enrico Coppola; Spinelli, Luisella; Novellino, Lorenzo

    2014-07-21

    Il cancro del polmone rappresenta la patologia maligna maggiormente diagnosticata a livello mondiale. La diffusione metastatica della malattia è piuttosto frequente. Oltre ai classici siti di metastatizzazione (ossea, surreni, fegato, cervello) un sito particolare è rappresentato dalla cute. Il caso presentato riguarda appunto un paziente di 66 anni con metastasi cutanea da neoplasia del polmone. Un uomo di 66 anni, con anamnesi positiva per anuerisma aortico sottorenale, BPCO, cardiopatico e diabetico, giunge alla nostra osservazione per neoplasia del lobo inferiore del polmone sinistro. Dopo un accurato staging preoperatorio, il paziente viene sottoposto a lobectomia inferiore sinistra. L’esito dell’esame istologico è di carcinoma squamocellulare moderatamente e scarsamente differenziato G2-3 pT2bN0. Il paziente viene pertanto inviato al collega oncologo per il regolare follow up. Dopo circa 6 mesi il paziente ritorna alla nostra attenzione per la comparsa a livello del fianco/fossa iliaca di destra di nodulo cutaneo, duro, discromico, dolente ed ulcerato. Le biopsie eseguite, hanno dato esito di carcinoma squamocellulare moderatamente e scarsamente differenziato. Il paziente veniva sottoposto a un TC torace- addome che evidenziava in sede della parete addominale l’assenza d’infiltrazione dei piani muscolo-aponeurotici da parte della neoformazione. Il paziente è stato quindi sottoposto ad intervento chirurgico di asportazione della lesione cutanea. L’esame istologico del pezzo operatorio ha confermato trattarsi di carcinoma squamocellulare metastatico. Le metastasi cutanee da carcinoma del polmone si presentano nel 2,5 - 7,5% dei casi. La sopravvivenza mediana di questi pazienti è di circa 2,9 mesi. L’istotipo maggiormente coinvolto, secondo autori Giapponesi, è l’adenocarcinoma seguito dal carcinoma squamocellulare. Alcuni studi hanno dimostrato la validità dell’approccio chirurgico seguito dalla chemioterapia nei casi di metastasi singole

  8. Teorie Dinamiche Dell' Ala

    NASA Astrophysics Data System (ADS)

    Finzi, Bruno

    Non è facile rendersi conto del birzarro comportamento dei fluidi poco viscosi, quali l'aria e l'acqua, deducendolo logicamente e matematicamente, come è nello spirito della fisica matematica, da poche proposizioni generali tratte dall'esperienza. Ciò perchè le schematizzazioni più semplici suggerite dal senso comune, in virtù del quale piccole cause non possono produrre che piccoli effetti, e facenti capo a campi cinetici ovunque regolari, portano a risultati paradossali sconcertanti, quali il paradosso di d'Alembert.

  9. Gamma-Ray Spectral States of Galactic Black Hole Candidates

    DTIC Science & Technology

    1998-01-01

    discovery outburst ( van der Hooft et al. 1996). A radio (Mirabel, Rodriguez, & Cordier 1993) and optical (Della Valle, Mirabel, & Cordier 1993) low-mass...e.g. Grove et al. (1994) for GRO J0422+32 and van der Hooft et al. (1996) for GRS 1716{249, where in both sources strong, rapid variability and peaked...Mastichiadis, A., & Kyla s, N.D., 1996, A&AS, 120, 171 van der Hooft , F. et al. 1996, ApJ, 458, L75 van der Klis, M. 1994, ApJS, 92, 511 van der Klis, M. 1995

  10. Main Port Mechanism for PRISMA

    NASA Astrophysics Data System (ADS)

    Caprini, G. C.; Ceccherini, M.; Brotini, M.; Bini, A.; Corsini, R.; Gasparini, L.; Battazza, F.; Formaro, R.

    2013-09-01

    A high complexity Main Port Mechanism (MPM) has been designed and produced by Selex ES in co- operation with HighFTech Engineering, an Italian PMI, in the frame of PRISMA (PRecursore IperSpettrale della Missione Applicativa) instrument.The Main Port Mechanism is located at the entrance of the Optical Head having the function of opening and closing a door.The paper describes the requirements drived the conceptual design, the detailed design and the qualification tests performed on the mechanism. A description of the foreseen test flow and set-up is also given.

  11. Military Command Team Effectiveness: Model and Instrument for Assessment and Improvement (L’efficacite des Equipes de Commandement Militaires: un Modele et un Instrument Pour L’evaluation et L’amelioration)

    DTIC Science & Technology

    2005-04-01

    military task at hand and with the leader’s abilities as leader of the team. Field Manual 22-100 (FM 22-100, 1999), which is the United States Army’s...Doctrinal Committee of the Royal Netherlands Army] (2000). Leidraad commandovoering [ Manual Command and Control]. The Hague. [64] Dose, J.J. (1999...197 21 Praha 9 Ryvangs Allé 1, P.O. Box 2715 Centro di Documentazione DK-2100 Copenhagen Ø Tecnico -Scientifica della Difesa ROYAUME-UNI Via XX

  12. Tycho Brahe and Egnazio Danti. Observations and astronomical research at Prague and Florence at the end of the 16th century

    NASA Astrophysics Data System (ADS)

    Triarico, Carlo

    The paper aims at pointing out the similarities between the astronomical research of Tycho Brahe and Egnazio Danti. The main issue is the comparison between the researches of the two astronomers about the measurement of the ecliptic's obliquity and its possible variation. The books published by the two scientists about the use and building up of the astronomical instruments will be also compared. Finally, will be given some examples of instruments of the Medici Family collection in the Istituto e Museo di Storia della Scienza in Florence, which come from Praha and were built by the technicians who worked for Tycho.

  13. Plant ubiquitin-proteasome pathway and its role in gibberellin signaling

    PubMed Central

    Wang, Feng; Deng, Xing Wang

    2011-01-01

    The ubiquitin-proteasome system (UPS) in plants, like in other eukaryotes, targets numerous intracellular regulators and thus modulates almost every aspect of growth and development. The well-known and best-characterized outcome of ubiquitination is mediating target protein degradation via the 26S proteasome, which represents the major selective protein degradation pathway conserved among eukaryotes. In this review, we will discuss the molecular composition, regulation and function of plant UPS, with a major focus on how DELLA protein degradation acts as a key in gibberellin signal transduction and its implication in the regulation of plant growth. PMID:21788985

  14. [Managment system in safety and health at work organization. An Italian example in public sector: Inps].

    PubMed

    Di Loreto, G; Felicioli, G

    2010-01-01

    The Istituto Nazionale della Previdenza Sociale (Inps) is one of the biggest Public Sector organizations in Italy; about 30.000 people work in his structures. Fifteen years ago, Inps launched a long term project with the objective to create a complex and efficient safety and health at work organization. Italian law contemplates a specific kind of physician working on safety and health at work, called "Medico competente", and 85 Inps's physicians work also as "Medico competente". This work describes how IT improved coordination and efficiency in this occupational health's management system.

  15. OSIRIS-REx Mission Science Briefing

    NASA Image and Video Library

    2016-09-06

    In the Kennedy Space Center’s Press Site auditorium, members of the media participate in a briefing on science experiments involved in NASA’s Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer, or OSIRIS-REx spacecraft. From left are: Nancy Neal-Jones of NASA Communications; Christina Richey, OSIRIS-REx deputy program scientist at NASA Headquarters in Washington; Jason Dworkin, OSIRIS-REx project scientist at NASA’s Goddard Space Flight Center in Greenbelt, Maryland; Daniella DellaGiustina, OSIRIS-REx lead image processing scientist at the University of Arizona, Tucson.

  16. The protective effect of melatonin on remote organ liver ischemia and reperfusion injury following aortic clamping.

    PubMed

    Ozsoy, Mustafa; Gonul, Yucel; Ozkececi, Ziya Taner; Bali, Ahmet; Celep, Ruchan Bahadir; Koçak, Ahmet; Adali, Fahri; Tosun, Murat; Celik, Sefa

    2016-01-01

    Dopo il ripristino della circolazione sanguigna e dell’ossigenazione possono verificarsi gravi danni locali e sistemici ai tessuti temporaneamente ischemici, noti come danni da riperfusione. Lo scopo di questo studio è stato quello di indagare sui possibili effetti protettivi della melatonina nei confronti dei danni sistemici da riperfuzione nel tessuto epatico a seguito dell’occlusione dell’aorta sottorenale. Per questo studio sono stati impiegati un totale di 21 ratti Wistar-albini di sesso maschile, suddivisi in tre gruppi: I gruppo – laparotomia e contemporanea dissezione dell’aorta infrarenale; II gruppo – somministrazione intraperitoneale di circa 1 ml di fisiologica al 0,9% di NaCl 30’ prima e dopo l’operazione di occlusione. Dopo la laparotomia e sua dissezione, l’aorta sottorenale è clampata per 30’ e quindi riabitata al circolo di riperfusione per 2 ore; III gruppo – 30’ prima del clampaggio dell’aorta sottorenale è stata somministrata la malatonina, seguita dal clampaggio aortico per 30’ e un periodo di riperfusione di 2 ore. Sono stati quindi dosati i tassi sierici di aspartate aminotransferasi, alanine aminotransferasi, and lattato dehydrogenase, risultati significativamente più elevate nei gruppi II e III rispetto al gruppo I di controllo. Gli esami di laboratorio sono tornati ai livelli normali nel III gruppo dopo il trattamento. Sebbene si sia avuto un decremento del tasso sierico di IL-1β, IL-6, IL-18, TNF-α, e IFN- γ nel gruppo trattato con melatonina, questo decremento ha assunto valore statisticamente significativo per i livelli sierici di IL- 18, TNF-α, e IFN- γ in paragone con quanto osservato nel II gruppo. I tassi sierici dello stato totale di antiossidanti tissutali (TOC) e dell’indice di stress ossidativo dei tessuti (OSI) sono risultati diminuiti e quelli della capacità antiossidante (TAC) risultano accresciuti dalla melatonina. Il risultato di questo studio suggerisce effetti antiossidanti della

  17. Water and its effects when drunk cold. The Physician's view (1576-1751).

    PubMed

    Bonfante, L; Calò, L; D'Angelo, A; Favaro, S; Abaterusso, C; Mennella, G; Normanno, M; Spinello, M; Antonello, A

    1999-01-01

    Starting with Baldassare Pisanelli's book Trattato della natura de' cibi et del bere, published in Venice in 1586, the controversies that have kept physicians busy over the centuries regarding the relative importance of water in human health are traced. These controversies were of considerable importance as the Latin word for water 'aqua' is derived from the phrase 'a qua vinimus' (from whence we come). However, until the studies of Nicolas Lemery, one of the most important pharmacologists of the 18th century, the controversies were debated using more theoretical, philosophical arguments. Lemery's studies shifted the debates from those based on philosophical arguments to more physiologically and scientifically based arguments.

  18. Vis-NIR Hyperspectral and Terahertz Imaging Investigations on a Fresco Painting on "Tavella" by Alessandro Gherardini

    NASA Astrophysics Data System (ADS)

    Doria, A.; Gallerano, G. P.; Giovenale, E.; Casini, A.; Cucci, C.; Picollo, M.; Poggesi, M.; Stefani, L.; Fukunaga, K.; Tamassia, M.

    2017-04-01

    In this paper, we report on Vis-IR hyperspectral and terahertz imaging investigations carried out on a fresco painting on tavella depicting St. John Baptist, by Alessandro Gherardini (1655-1726). Measurements took place at the Restoration Laboratories of the former "Polo Museale della Toscana," in Florence, in the framework of the Italy-Japan collaborative project THz-ARTE. We show how the hyperspectral data made it possible to determine the state-of-conservation of Gherardini's painting, while reflection imaging measurements performed at 97 GHz provided a qualitative evaluation of the position of defects inside the tavella.

  19. Splenic abscess after splenic blunt injury angioembolization.

    PubMed

    Tartaglia, Dario; Galatioto, Christian; Lippolis, Piero Vincenzo; Modesti, Matteo; Gianardi, Desirée; Bertolucci, Andrea; Cucinotta, Monica; Zocco, Giuseppe; Seccia, Massimo

    2014-11-03

    L’angioembolizzazione splenica è una efficace procedura nel corso del trattamento non operativo dei pazienti emodinamicamente stabili con traumi splenici di grado OIS III, IV, V. L’ascesso spenico rappresenta una rara complicanza maggiore di questa procedura. Di seguito riportiamo il caso di un paziente di 38 anni, giunto in Pronto Soccorso dopo una caduta accidentale domestica, con contusione del quadrante superiore sinistro dell’addome. La TC addome documentava una frattura del polo inferiore della milza, con pseudoaneurismi intraparenchimali (grado IV OIS). Vista la stabilità emodinamica, il paziente veniva sottoposto a trattamento non operatvo. Successivamente si eseguiva un’angioembolizzazione della parte distale dell’ arteria splenica con spongostan gel e spirali metalliche. Per la comparsa di febbre e per l’evidenza di sepsi agli esami ematochimici, si effettuava un’ ulteriore TC addome che evidenziava la presenza di una voluminosa raccolta di circa 11 cm all’ interno della milza con multiple bolle aree nel suo contesto, con segni di emoperitoneo diffuso nei recessi addominali. Per tale motivo, ad una settimana dalla procedura, il paziente veniva sottoposto ad intervento chirurgico di splenectomia con evacuazione del versamento ematico. Gli esami colturali eseguiti sull’ematoma perisplenico risultavano negativi, ma l’esame istologico della milza documentava multiple aree ascessualizzate ed emorragiche. Dopo un ciclo di terapia antibiotica a largo spettro con Tigeciclina e Teicoplanina, il paziente veniva dimesso in sedicesima giornata post-operatoria. In letteratura, è stato riportato che gli ascessi splenici dopo la procedura di angioembolizzazione splenica nel corso di un trattamento non operativo dei traumi splenici, si verificano nel range dello 0-1,9%. In circa un terzo dei casi richiedono un trattamento chirurgico. Nel caso riportato l’ascesso splenico si è sviluppato nel giro di una settimana dalla procedura. In conclusione

  20. OSIRIS-REx Mission Science Briefing

    NASA Image and Video Library

    2016-09-06

    In the Kennedy Space Center’s Press Site auditorium, members of the media participate in a briefing on science experiments involved in NASA’s Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer, or OSIRIS-REx spacecraft. From left are: Christina Richey, OSIRIS-REx deputy program scientist at NASA Headquarters in Washington; Jason Dworkin, OSIRIS-REx project scientist at NASA’s Goddard Space Flight Center in Greenbelt, Maryland; Daniella DellaGiustina, OSIRIS-REx lead image processing scientist at the University of Arizona, Tucson.

  1. Infraspinatus strength assessment and ultrasound evaluation of posterior capsulotenodesis after arthroscopic hill-sachs remplissage in traumatic anterior glenohumeral instability: a retrospective controlled study protocol.

    PubMed

    Merolla, Giovanni; Porcellini, Giuseppe

    2014-04-01

    Giovanni Merolla Co-investigator: Giuseppe Porcellini Investigation performed at the Biomechanics Laboratory "Marco Simoncelli", D. Cervesi Hospital, Cattolica - Italy PLAN OF CLINICAL INVESTIGATION (PCI): Version 1.0 of June 12, 2012 Approved by AV/IRST Ethical Committee (Comitato Etico Area Vasta Romagna) and authorized by AUSL RN ("Determina AUSL Rimini numero 326 del 29/03/2013: Remplissage U.O Chirurgia della Spalla - Valutazione clinica ed ultrasonografica dell'infraspinato dopo capsulo-tenodesi artroscopica (remplissage) nell'instabilità anteriore traumatica di spalla con lesione di Bankart e difetto omerale di Hill-Sachs").

  2. A simple model for understanding the DIM dust measurement at comet 67P/Churyumov-Gerasimenko

    NASA Astrophysics Data System (ADS)

    Podolak, Morris; Flandes, Alberto; Della Corte, Vincenzo; Krüger, Harald

    2016-11-01

    We present a simple model for gas and dust flow from 67P/Churyumov-Gerasimenko that can be used to understand the grain impact observed by the DIM instrument on Philae (Krüger et al., 2015). We show how model results when applied to the GIADA measurements (Rotundi et al., 2015; Della Corte et al., 2015) can be used, in conjunction with the results found by the MIRO (Schloerb et al., 2015) and VIRTIS (De Sanctis et al., 2015) instruments to infer surface properties such as surface temperature and surface ice fraction.

  3. Ambienti Circumstellari ed Interstellari di Supernovae di vario Tipo ed Applicazioni Astrofisiche

    NASA Astrophysics Data System (ADS)

    Boffi, Francesca R.

    Nella presente tesi vengono studiati gli ambienti circumstellari ed interstellari di supernovae (anche SNe; singolare SN) di vario tipo. In particolare si descrivono alcune applicazioni astrofisiche, relative a questi ambienti, che permettono di desumere informazioni sui sistemi stellari progenitori delle supernovae o di determinare le distanze a tali oggetti. L' emissione radio da supernovae, prodotta nell' ambiente circumstellare ad opera dell'interazione idrodinamica del gas di SN con l' ambiente circostante, puo' essere impiegata come mezzo di indagine del sistema di pre-supernova. In particolare si e' introdotta l'idea che tale emissione possa essere impiegata nel caso delle SNe di tipo Ia come test dei sistemi progenitori di tipo simbiotico. Il test e' stato effettuato sulla SN 1986G, per la quale avevamo ottenuto limiti superiori a lunghezze d'onda radio. Nel caso che un sistema simbiotico sia responsabile di una SN Ia, l'interazione tra l' ejecta e una shell circumstellare origina, in un'epoca molto prossima al massimo di luce, un'emissione radio rivelabile con strumenti tipo Very Large Array. Inoltre l'emissione radio fornisce informazioni circa gli stadi di pre-supernova nel caso di altri tipi di supernova. In questo lavoro di tesi vengono presentati i risultati ottenuti nel caso delle SNe di tipo II 1984E e 1986E. Queste due SNe non mostrano emissione radio: la prima, in prossimita del massimo ottico, stava interagendo con una shell circumstellare prodotta da un episodio di perdita di massa di breve durata in fase di pre-supernova; la seconda, invece e' la prima SN ``vecchia'' ad essere rivelata nell' ottico ma non nel radio (l' oggetto non ha ancora iniziato la fase di supernova remnant ed emette radiazione ottica prodotta ancora per interazione circumstellare). In ambiente circum-interstellare, gli echi di luce, prodotti dallo scattering della luce della supernova ad opera della polvere presente, possono essere utilizzati per determinare le distanze

  4. Reclamation and agricultural reuse of wastewater: the experience of the Cagliari sewage treatment plant (Sardinia, Italy).

    PubMed

    Botti, P; Virdis, A; Solinas, G; Buscarinu, P; Ferralis, M; Marras, G; Spanu, P; Vacca, S

    2009-01-01

    In Sardinia, as in many other Mediterranean regions, recurrent droughts and climate change have dramatically reduced available water resources. As a result of this critical situation, in 1995 the Italian Government declared a state of emergency and drew up a program for financial support by the State and local authorities with the aim of reducing this serious deficit. One of the actions focused on reclaiming and reusing the effluent from the sewage treatment plant of Cagliari. This article reports on the multidisciplinary preliminary study performed by the Ente Acque della Sardegna (ENAS) to evaluate the suitability of reusing Is Arenas effluent for irrigation and on the operation of the tertiary treatment plant.

  5. Vis-NIR Hyperspectral and Terahertz Imaging Investigations on a Fresco Painting on "Tavella" by Alessandro Gherardini

    NASA Astrophysics Data System (ADS)

    Doria, A.; Gallerano, G. P.; Giovenale, E.; Casini, A.; Cucci, C.; Picollo, M.; Poggesi, M.; Stefani, L.; Fukunaga, K.; Tamassia, M.

    2017-01-01

    In this paper, we report on Vis-IR hyperspectral and terahertz imaging investigations carried out on a fresco painting on tavella depicting St. John Baptist, by Alessandro Gherardini (1655-1726). Measurements took place at the Restoration Laboratories of the former "Polo Museale della Toscana," in Florence, in the framework of the Italy-Japan collaborative project THz-ARTE. We show how the hyperspectral data made it possible to determine the state-of-conservation of Gherardini's painting, while reflection imaging measurements performed at 97 GHz provided a qualitative evaluation of the position of defects inside the tavella.

  6. [Assessment of a project for integrated management of care given to patients with type-2 diabetes in the Local Health Authority 21 of Legnago (Veneto Region, Northern Italy) in the period 2010-2012].

    PubMed

    Marcon, Alessandro; Vaona, Alberto; Rigon, Giulio; Carazzolo, Marco; Del Zotti, Franco; Girotto, Sandro; Marafetti, Claudio

    2016-01-01

    OBIETTIVI: descrivere, nella ASL 21 di Legnago (VR), l'andamento di alcuni indicatori sanitari tra il 2009, anno precedente all'avvio di un progetto triennale per la gestione integrata dell'assistenza al paziente con diabete mellito di tipo 2, e il 2012, ultimo anno del progetto. DISEGNO: studio longitudinale trasversale ripetuto. SETTING E PARTECIPANTI: tutti i pazienti diabetici di tipo 2 della ASL 21, identificati nei database aziendali (in base a esenzioni per patologia, accessi al servizio diabetologico, consumo di farmaci antidiabetici e strisce per la determinazione della glicemia) e nelle cartelle cliniche dei medici di famiglia. PRINCIPALI MISURE DI OUTCOME: numero di test diagnostici e di follow-up erogati, consumo di farmaci, prestazioni specialistiche, accessi al pronto soccorso, ricoveri e mortalità. RISULTATI: nonostante un calo generalizzato (-3,1%) nei test erogati dalla ASL 21 ai suoi assistititi nel periodo 2009-2012, l'analisi ha documentato un marcato aumento per gli esami previsti nella gestione del diabete, quali curve da carico glicemico (+104,3%), emoglobina glicata (+19,0%) e microalbuminuria (+296,1%). I soggetti identificati come diabetici sono aumentati da 8.084 nel 2009 (5,2%) a 9.221 nel 2012 (5,9%). Sono stati osservati aumenti nella prevalenza di pazienti visitati presso un servizio diabetologico (dal 22,6% al 39,0%), nonché negli utilizzatori di metformina (dal 28,0% al 37,5%), insuline (dal 13,5% al 18,3%) e incretine (dall'1,4% al 9,0%). Il consumo di sulfaniluree è, invece, calato (dal 49,9% al 40,8%), come anche l'erogazione di alcune prestazioni specialistiche, gli accessi al pronto soccorso e i ricoveri, mentre il tasso di mortalità è rimasto stabile (29,6 decessi x1.000/anno). CONCLUSIONE: durante il periodo di implementazione del progetto sembra essersi verificato un aumento della sensibilità diagnostica e una maggiore presa in carico del paziente diabetico. Anche se la natura osservazionale dello studio non consente

  7. Gastric paraganglioma: a case report and a review of the literature.

    PubMed

    Pruiti, Vincenzo; Mazzeo, Francesca; Rossitto, Maurizio; Foti, Agata; Macrì, Antonio; Cucinotta, Eugenio

    2014-12-29

    I paragangliomi sono tumori neuroendocrini derivati dalla cresta neurale, provenienti dai paragangli, organi neuroendocrini dispersi e caratterizzati da cellule producenti catecolamine e peptidi. Presentano un’incidenza annuale stimata in 1 / 100.000, rappresentando il 10% dei tumori secernenti catecolamine. Riportiamo il caso di un uomo di 76 anni giunto alla nostra osservazione per la presenza di una lesione polipoide di 4 cm, vegetativaulcerata, tra il corpo e dell’antro gastrico rilevata durante una gastroscopia per la comparsa di anemia. Il paziente è stato sottoposto a gastrectomia subtotale con omentectomia e anastomosi gastrodigiunale. L’esame istologico ha rivelato un carcinoma gastrico polipoide ulcerato con cellule scarsamente aderenti con infiltrazione della parete gastrica muscolare e incidentalmente è stata identificata una lesione della parete gastrica posteriore incidentale che si rilevava essre un paraganglioma con la positività alle indagini di immunocitochimica per NSE e negatività per CD117, S100, CD34 e SMA. Con il termine di feocromocitoma si indica esclusivamente i tumori derivanti dalla midollare del surrene, mentre il paraganglioma extra-surrenalico suggerisce tumori delle cellule cromaffini con altre posizioni. La localizzazione gastrica o perigastrica, come nel nostro caso, è molto rara per queste neoplasie, e in letteratura vi sono solo pochi case report. La predisposizione genetica si osserva nel 30% di questi tumori e può essere responsabile della malattia ereditaria caratterizzata da differenze nella distribuzione del tumore, nella produzione di catecolamine, nel rischio di metastasi, e nell’associazione con altri tipi di tumori. In conclusione, nei pazienti con sintomi di tumore secernente cromaffini o in pazienti con una storia familiare di feocromocitoma-paraganglioma, che portano mutazioni e sottoposti a screening per il tumore asintomatico, la prima indagine diagnostica è determinare i livelli di metanefrina

  8. Asymptotic form of the Kohn-Sham correlation potential

    SciTech Connect

    Joubert, D. P.

    2007-07-15

    The density-functional correlation potential of a finite system is shown to asymptotically approach a nonzero constant along a nodal surface of the energetically highest occupied orbital and zero everywhere else. This nonuniform asymptotic form of the correlation potential exactly cancels the nonuniform asymptotic behavior of the exact exchange potential discussed by Della Sala and Goerling [Phys. Rev. Lett. 89, 33003 (2002)]. The sum of the exchange and correlation potentials therefore asymptotically tends to -1/r everywhere, consistent with the asymptotic form of the Kohn-Sham potential as analyzed by Almbladh and von Barth [Phys. Rev. B 31, 3231 (1985)].

  9. Cloning and Expression of Genes for Dengue Virus Type-2 Encoded-Antigens for Rapid Diagnosis and Vaccine Development

    DTIC Science & Technology

    1990-12-12

    Della-Porta and Westaway, 1977; Kitano et al., 1974; Heinz et al., 1981). In order to develop a subunit vaccine against dengue virus, it is important to...Antigens for Rapid Diagnosis and Vaccine Development DPC TAB 0 A .. asin]o ANNUAL PROGRESS REPORT ’Q;-10.v&,,,d 0 by By SAv.ailability Caote# Radha Krishnan...Type 2 Encoded Antigens for Rapid Diagnosis and Vaccine Development 12. PERSONAL AUTHOR(S) Radha K. Padmanabhan 13a. TYPE OF REPORT 13b. TIME COVERED

  10. Malignant transformation in non-recurrent peritoneal cystic mesothelioma Our experience and review of the literature.

    PubMed

    Santangelo, Giuseppe; Accardo, Marina; De Vita, Ferdinando; Del Giudice, Santolo; Gallucci, Federica; Fabozzi, Alessio; De Falco, Massimo

    2016-01-29

    Il mesotelioma peritoneale cistico è un tumore raro. Si tratta di un tumore benigno, che tuttavia va incontro a recidive locali post-chirurgiche in oltre il 50% dei casi. È proprio a seguito di recidive ricorrenti che si possono determinare trasformazioni maligne di questa neoplasia, come descritto in Letteratura. Nel Giugno del 2004 un paziente di 73 anni è giunto presso la nostra struttura con una tumefazione addominale causa di dolore gravativo: si trattava di una massa di 16 cm, la cui struttura, agli esami strumentali (ecografia, TC con m.d.c. e RMN), appariva pluricistica. Attraverso una laparotomia mediana si è provveduto alla sua rimozione e il paziente è stato dimesso in VIII giornata post-operatoria senza complicanze. L’esame istologico, corredato da studio immunoistochimico e di microscopia elettronica, ha consentito di porre diagnosi di mesotelioma peritoneale pluricistico in trasformazione maligna. D’accordo con gli oncologi, in considerazione della scarsa efficacia dei trattamenti adiuvanti e della scarsità dei dati riportati in Letteratura sull’argomento, si è deciso di sottoporre il paziente unicamente ad uno stretto follow-up, con esecuzione di ecografia addominale ogni sei mesi e TC addominale ogni anno. Ad oggi, dieci anni dopo il trattamento, il paziente, di 83 anni, gode di un discreto stato di salute e non si sono verificate riprese o recidive di malattia, né locali, né a distanza. Oltre al fatto di essere risultato maligno alla sua prima manifestazione e non dopo ripetute recidive, il caso presenta altre particolarità: il mesotelioma peritoneale cistico, infatti, solitamente colpisce soggetti di sesso femminile (con un rapporto F:M di 4,5:1) ad un’età media di 60 anni, mentre il caso descritto riguarda un soggetto di sesso maschile di 73 anni. La nostra osservazione dimostra la possibilità che il mesotelioma peritoneale vada incontro a trasformazioni maligne già alla sua prima manifestazione e non esclusivamente dopo

  11. Comparison of multiple training models of surgical rotation for third-year medical students A prospective study.

    PubMed

    Magistri, Paolo; Nigri, Giuseppe; Petrucciani, Niccolò; Aurello, Paolo; D'Angelo, Francesco; Ramacciato, Giovanni

    2016-01-01

    Considerata la necessità di elaborare un sistema di rotazione nei reparti di Chirurgia che venga incontro alle necessità degli studenti, abbiamo ideato questo studio prospettico presso la Facoltà di Medicina e Psicologia di “Sapienza, Università di Roma”. Nella nostra Istituzione, gli studenti del terzo anno del corso di laurea di Medicina e Psicologia trascorrono un periodo di 2 mesi presso il reparto di Chirurgia Generale per prepararsi all’esame di Semeiotica Medico-Chirurgica. Spesso i feedback di tale esperienza riportano una certa insoddisfazione, soprattutto per la scarsità dell’attività pratica al letto del paziente. Pertanto, abbiamo deciso di confrontare cinque modelli per stabilire il migliore approccio in termini di apprendimento e soddisfazione degli studenti. 28 studenti sono stati coinvolti nello studio e divisi in cinque gruppi (da A ad E). Il Gruppo A ha eseguito una rotazione standard così come prevista dall’ordine degli studi, 5 accessi in reparto seguiti dal proprio tutor. Gli studenti del gruppo B hanno frequentato il reparto una volta la settimana, arrivando dopo la visita della mattina, trascorrendo un’ora con il tutor ed il resto della mattina con gli specializzandi. Il gruppo C è stato diviso in piccoli gruppi, ciascuno assegnato per 2 volte all’ambulatorio chirurgico, 2 volte in reparto (standard) e 2 volte al servizio di preospedalizzazione. Gli studenti del gruppo D hanno frequentato il reparto una volta la settimana arrivando la mattina presto, trascorrendo 2 ore con il tutor ed il resto della mattina con gli specializzandi. Il gruppo E è stato diviso in 2 gruppi, ciascuno assegnato 3 volte al reparto (standard) e 3 volte alla sala operatoria. Ciascuno studente ha completato un questionario con 20 item di semeiotica all’inizio ed alla fine dello studio per valutare la progressione dell’apprendimento, ed un questionario finale di valutazione della soddisfazione. I risultati hanno dimostrato come tutti i gruppi

  12. [Nurses in print].

    PubMed

    1990-01-01

    The paper presents an analysis of the articles on nursing personnel published from September 1989 till June 1990 in the two most widespread newspapers: II Corriere della Sera and La Republica. The nursing profession has been a very important object of nation as well as local chronicles, specifically during the nationwide "nursing emergency." It is striking however to see that nurses themselves are absent as subjects from the debate on the crisis of the profession. It is further underlined that journalists are very rough in their analyses of the cause of professional malaise and in the formulation and discussion of hypotheses for solution.

  13. Evolving Arms Transfer Rationales: The Case of Italy

    DTIC Science & Technology

    1987-06-01

    began to 5 Libro Bianco-La Difesa, 1977, 57-92. 6 1bid. 23 reconstitute and reequip her armed forces. The 1950’s were tumultuous for the activity in...discussion of the early arms trade in Italy. 8 La Difesa-- Libro Bianco, Ministero della Difesa d’Italia, 1985. 74. 24 in recognizing the problem, the... Libro Bianco, p.xiv. This quote is a portion of the introduction to the White Book written by the Minister of Defense, Giovanni Spadolini. 31 however

  14. An astrolabe attributed to Gerard Mercator, c. 1570

    NASA Astrophysics Data System (ADS)

    Turner, Gerard L'E.; Dekker, Elly

    The Istituto e Museo di Storia della Scienza, Florence, Italy, possesses an astrolabe with five latitude plates that is now attributed to the Duisburg workshop of Gerard Mercator. Although it is known that Mercator made instruments, this is the first surviving example to be identified. Another latitude plate is shown to come from the workshop of the Florentine, Giovan Battista Giusti. A seventh plate, possibly engraved by Rumold Mercator, provides the only known Mercatorian polar stereographic projection. The role of Egnazio Danti, cosmographer to the Grand Duke of Tuscany, in the acquisition of the astrolabe in about 1570 is considered.

  15. Fast and Accurate Multivariate Gaussian Modeling of Protein Families: Predicting Residue Contacts and Protein-Interaction Partners

    PubMed Central

    Feinauer, Christoph; Procaccini, Andrea; Zecchina, Riccardo; Weigt, Martin; Pagnani, Andrea

    2014-01-01

    In the course of evolution, proteins show a remarkable conservation of their three-dimensional structure and their biological function, leading to strong evolutionary constraints on the sequence variability between homologous proteins. Our method aims at extracting such constraints from rapidly accumulating sequence data, and thereby at inferring protein structure and function from sequence information alone. Recently, global statistical inference methods (e.g. direct-coupling analysis, sparse inverse covariance estimation) have achieved a breakthrough towards this aim, and their predictions have been successfully implemented into tertiary and quaternary protein structure prediction methods. However, due to the discrete nature of the underlying variable (amino-acids), exact inference requires exponential time in the protein length, and efficient approximations are needed for practical applicability. Here we propose a very efficient multivariate Gaussian modeling approach as a variant of direct-coupling analysis: the discrete amino-acid variables are replaced by continuous Gaussian random variables. The resulting statistical inference problem is efficiently and exactly solvable. We show that the quality of inference is comparable or superior to the one achieved by mean-field approximations to inference with discrete variables, as done by direct-coupling analysis. This is true for (i) the prediction of residue-residue contacts in proteins, and (ii) the identification of protein-protein interaction partner in bacterial signal transduction. An implementation of our multivariate Gaussian approach is available at the website http://areeweb.polito.it/ricerca/cmp/code. PMID:24663061

  16. Critical Analysis and Digital Reconstructions of Alberti's Architectures by the Use of 3d Morphometric Integrated Survey Database

    NASA Astrophysics Data System (ADS)

    Ferrari, F.; Medici, M.

    2017-02-01

    Since 2005, DIAPReM Centre of the Department of Architecture of the University of Ferrara, in collaboration with the "Centro Studi Leon Battista Alberti" Foundation and the Consorzio Futuro in Ricerca, is carrying out a research project for the creation of 3D databases that could allow the development of a critical interpretation of Alberti's architectural work. The project is primarily based on a common three-dimensional integrated survey methodology for the creation of a navigable multilayered database. The research allows the possibility of reiterative metrical analysis, thanks to the use of a coherent data in order to check and validate hypothesis by researchers, art historians and scholars on Alberti's architectural work. Coherently with this methodological framework, indeed, two case studies are explained in this paper: the church of San Sebastiano in Matua and The Church of the Santissima Annunziata in Florence. Furthermore, thanks to a brief introduction of further developments of the project, a short graphical analysis of preliminary results on Tempio Malatestiano in Rimini opens new perspectives of research.

  17. Heparin in pregnant women with previous placenta-mediated pregnancy complications: a prospective, randomized, multicenter, controlled clinical trial.

    PubMed

    Martinelli, Ida; Ruggenenti, Piero; Cetin, Irene; Pardi, Giorgio; Perna, Annalisa; Vergani, Patrizia; Acaia, Barbara; Facchinetti, Fabio; La Sala, Giovanni Battista; Bozzo, Maddalena; Rampello, Stefania; Marozio, Luca; Diadei, Olimpia; Gherardi, Giulia; Carminati, Sergio; Remuzzi, Giuseppe; Mannucci, Pier Mannuccio

    2012-04-05

    To assess whether antithrombotic prophylaxis with low-molecular-weight heparin effectively prevents recurrence of late pregnancy complications, 135 women with previous history of preeclampsia, hemolytic anemia, elevated liver enzymes and low platelet count syndrome, intrauterine fetal death, fetal growth restriction, or placental abruption who had been referred within the 12th gestational week were randomized to medical surveillance alone (n = 68) or combined to open-label nadroparin (3800 IU daily subcutaneous injections) treatment (n = 67) in the setting of a randomized, parallel-group, superiority trial, run in Italy from April 2007 to April 2010. Primary outcome was a composite end point of late-pregnancy complications. Analysis was by intention to treat. The study was stopped for futility at the time of the first planned interim analysis. Among the 128 women eventually available for final analyses, 13 of the 63 (21%) randomized to nadroparin compared with 12 of the 65 (18%) on medical surveillance alone progressed to the primary end point. The absolute event risk difference between treatment arms (2.2; -1.6 to 16.0) was not statistically significant (P = .76). Thus, nadroparin did not prevent late-pregnancy complications in women at risk of recurrence. This finding challenges the role of antithrombotic prophylaxis with low-molecular-weight heparin in the prevention of recurrent late pregnancy complications The trial was registered at http://ricerca-clinica.agenziafarmaco.it as EudraCT 2006-004205-26.

  18. Development, Testing and Installation of a Superconducting Fault Current Limiter for Medium Voltage Distribution Networks

    NASA Astrophysics Data System (ADS)

    Martini, Luciano; Bocchi, Marco; Ascade, Massimo; Valzasina, Angelo; Rossi, Valerio; Angeli, Giuliano; Ravetta, Cesare

    Since 2009 Ricerca sul Sistema Energetico (RSE S.p.A.) has been involved in the design of resistive-type Superconducting Fault Current Limiter (SFCL) for MV applications to be installed in the A2A Reti Elettriche S.p.A distribution grid in the Milano area. The project started with simulations, design and testing activities for a singlephase device; in this paper we report on the successive step, which is concerned with developing, testing and installation at the hosting utility of the final three-phase SFCL prototype. The result of this research activity is a resistive-type 9 kV/3.4 MVA SFCL device, based on first generation (1G) BSCCO tapes, developed by RSE in the framework of a R&D national project. Owing to the positive test results of partial discharge, dielectric and shortcircuit results the three-phase SFCL device is being to be installed in the A2A distribution grid in the Milano area and it is going to be soon energized starting a one-year long field-testing activity.

  19. Measuring Humidity in Methane and Natural Gas with a Microwave Technique

    NASA Astrophysics Data System (ADS)

    Gavioso, R. M.; Madonna Ripa, D.; Benyon, R.; Gallegos, J. G.; Perez-Sanz, F.; Corbellini, S.; Avila, S.; Benito, A. M.

    2014-04-01

    The results of microwave measurements with a quasi-spherical resonator in humid methane samples realized under laboratory conditions at the Istituto Nazionale di Ricerca Metrologica (INRiM) and under industrial conditions in a natural gas sample made available at the facilities of the Technical Manager of the Spanish Gas System and main supplier of natural gas in Spain (ENAGAS) are reported. Measurements at INRiM included vapor phase and condensation tests on methane samples prepared with amount fractions of water between 600 ppm and 5000 ppm at temperatures between 273 K and 295 K and pressures between 150 kPa and 1 MPa. ENAGAS measurements were performed at ambient temperature, 750 kPa on natural gas sampled from the pipeline and successively humidified at amount fractions of water between 140 ppm and 250 ppm for completeness of the comparison with several humidity sensors and instrumentation based on different technologies. To enhance the sensitivity of the microwave method at low humidity, an experimental procedure based on the relative comparison of the dielectric permittivity of the humid gas sample before and after being subject to a chemical drying process was conceived and implemented. The uncertainty budget and the final sensitivity of this procedure are discussed.

  20. Mean sea-level height variations in the Central Mediterranean

    NASA Astrophysics Data System (ADS)

    Zerbini, Susanna; Bruni, Sara; Errico, Maddalena; Petracca, Fernanda; Raicich, Fabio; Santi, Efisio

    2015-04-01

    The Italian tide gauge network has experienced difficulties during last century. However, historical time series, starting from the end of the ninetieth century, are available in the PSMSL data base (Permanent Service for Mean Sea Level, http://www.psmsl.org/data/). Data from the early 1980s can also be obtained from the data base of ISPRA (Istituto Superiore per la Protezione e la Ricerca Ambientale, http://www.mareografico.it). In 1998, the Italian national tide gauge network (Rete Mareografica Nazionale - RMN) was completely restructured; it consists of 36 homogeneously distributed stations providing measurements sampled every 10 minutes. We have analyzed both the historical and the recent time series of a sub set of stations located in the Tyrrhenian area by using the Empirical Orthogonal Functions (EOF) approach. The EOF analysis allows describing one data set as a linear combination of orthogonal components, or modes, that depend on position only, while the linear combination coefficients are functions of time only. Each mode is associated to a percentage of the total variance of the original data set, which accounts for the relative importance of the corresponding mode of variability. The aim of this work is to identify common modes which could possibly be related to wide area crustal deformation and/or to climatic fluctuations, such as the inverted barometer effect.

  1. Argon Triple-Point Device for Calibration of SPRTs

    NASA Astrophysics Data System (ADS)

    Kołodziej, B.; Manuszkiewicz, H.; Szmyrka-Grzebyk, A.; Lipiński, L.; Kowal, A.; Steur, P. P. M.; Pavese, F.

    2015-03-01

    This paper presents an apparatus for the calibration of long-stem platinum resistance thermometers at the argon triple point , designed at the Institute of Low Temperature and Structural Research, Poland (INTiBS). A hermetically sealed cell filled at the Istituto Nazionale di Ricerca Metrologica, Italy with high purity gas (6N) is the main element of this apparatus. The cell is placed in a cryostat fully immersed in liquid nitrogen. A temperature-controlled shield ensures the quasi-adiabatic condition needed for proper realization of the phase transition. A system for correcting the temperature distribution along the thermometer well is also implemented. The cell cooling and argon solidification is carried out by filling the thermometer well with liquid nitrogen. A LabVIEW computer program written at INTiBS automatically controls the triple-point realization process. The duration of a melting plateau in the apparatus lasts for about 24 h. The melting width for between 20 % and 80 % was mK. The reproducibility of the plateau temperature is better than.

  2. Monte Carlo simulation of the photoneutron field in linac radiotherapy treatments with different collimation systems

    NASA Astrophysics Data System (ADS)

    Zanini, A.; Durisi, E.; Fasolo, F.; Ongaro, C.; Visca, L.; Nastasi, U.; Burn, K. W.; Scielzo, G.; Adler, J. O.; Annand, J. R. M.; Rosner, G.

    2004-02-01

    Bremsstrahlung photon beams produced by linac accelerators are currently the most commonly used method of radiotherapy for tumour treatments. When the photon energy exceeds 10 MeV the patient receives an undesired dose due to photoneutron production in the accelerator head. In the last few decades, new sophisticated techniques such as multileaf collimators have been used for a better definition of the target volume. In this case it is crucial to evaluate the photoneutron dose produced after giant dipole resonance (GDR) excitation of the high Z materials (mainly tungsten and lead) constituting the collimator leaves in view of the optimization of the radiotherapy treatment. A Monte Carlo approach has been used to calculate the photoneutron dose arising from the GDR reaction during radiotherapy with energetic photon beams. The simulation has been performed using the code MCNP4B-GN which is based on MCNP4B, but includes a new routine GAMMAN to model photoneutron production. Results for the facility at IRCC (Istituto per la Ricerca e la Cura del Cancro) Candiolo (Turin), which is based on 18 MV x-rays from a Varian Clinac 2300 C/D, are presented for a variety of different collimator configurations.

  3. Pescara benchmark: overview of modelling, testing and identification

    NASA Astrophysics Data System (ADS)

    Bellino, A.; Brancaleoni, F.; Bregant, L.; Carminelli, A.; Catania, G.; Di Evangelista, A.; Gabriele, S.; Garibaldi, L.; Marchesiello, S.; Sorrentino, S.; Spina, D.; Valente, C.; Zuccarino, L.

    2011-07-01

    The `Pescara benchmark' is part of the national research project `BriViDi' (BRIdge VIbrations and DIagnosis) supported by the Italian Ministero dell'Universitá e Ricerca. The project is aimed at developing an integrated methodology for the structural health evaluation of railway r/c, p/c bridges. The methodology should provide for applicability in operating conditions, easy data acquisition through common industrial instrumentation, robustness and reliability against structural and environmental uncertainties. The Pescara benchmark consisted in lab tests to get a consistent and large experimental data base and subsequent data processing. Special tests were devised to simulate the train transit effects in actual field conditions. Prestressed concrete beams of current industrial production both sound and damaged at various severity corrosion levels were tested. The results were collected either in a deterministic setting and in a form suitable to deal with experimental uncertainties. Damage identification was split in two approaches: with or without a reference model. In the first case f.e. models were used in conjunction with non conventional updating techniques. In the second case, specialized output-only identification techniques capable to deal with time-variant and possibly non linear systems were developed. The lab tests allowed validating the above approaches and the performances of classical modal based damage indicators.

  4. Metrological traceability of carbon dioxide measurements in atmosphere and seawater

    NASA Astrophysics Data System (ADS)

    Rolle, F.; Pessana, E.; Sega, M.

    2017-05-01

    The accurate determination of gaseous pollutants is fundamental for the monitoring of the trends of these analytes in the environment and the application of the metrological concepts to this field is necessary to assure the reliability of the measurement results. In this work, an overview of the activity carried out at Istituto Nazionale di Ricerca Metrologica to establish the metrological traceability of the measurements of gaseous atmospheric pollutants, in particular of carbon dioxide (CO2), is presented. Two primary methods, the gravimetry and the dynamic dilution, are used for the preparation of reference standards for composition which can be used to calibrate sensors and analytical instrumentation. At present, research is carried out to lower the measurement uncertainties of the primary gas mixtures and to extend their application to the oceanic field. The reason of such investigation is due to the evidence of the changes occurring in seawater carbonate chemistry, connected to the rising level of CO2 in the atmosphere. The well established activity to assure the metrological traceability of CO2 in the atmosphere will be applied to the determination of CO2 in seawater, by developing suitable reference materials for calibration and control of the sensors during their routine use.

  5. Lifestyle and eating habits in a business community.

    PubMed

    Stefani, L; Francini, L; Petri, C; Mascherini, G; Scacciati, I; Maffulli, N; Galanti, G

    2014-09-01

    The present study verified, using a validated questionnaire, the presence of unhealthy aspects of lifestyle and chronic degenerative conditions in a working community. A cohort from a working community in Italy was investigated using of the INRAN (Istituto Nazionale di Ricerca per gli Alimenti e Nutrizione) questionnaire dedicated to the eating habits and Physical Activity Stages of Change. Most of the 93 subjects (56 females and 37 males, aged 42.0±0.7) recruited reported low levels of physical activity (70 subjects). Slightly more than 50% of the subjects undertook physical activity more than once a week, while 13% did it only once. Food intolerances were reported by 7 subjects (8%), with a high consumption of fruits, cereals and dairy products, low consumption of fish and alcohol, and meat consumption in the normal range. There was a high satisfaction in general quality of life. Questionnaire investigations play a role to identify the presence of degenerative chronic conditions in working communities. The self-reported perception of quality of life does not necessarily agree with the lifestyle habits found. Awareness of this aspect could be helpful to plan lifestyle interventions and promote healthy living habits.

  6. Fast and accurate multivariate Gaussian modeling of protein families: predicting residue contacts and protein-interaction partners.

    PubMed

    Baldassi, Carlo; Zamparo, Marco; Feinauer, Christoph; Procaccini, Andrea; Zecchina, Riccardo; Weigt, Martin; Pagnani, Andrea

    2014-01-01

    In the course of evolution, proteins show a remarkable conservation of their three-dimensional structure and their biological function, leading to strong evolutionary constraints on the sequence variability between homologous proteins. Our method aims at extracting such constraints from rapidly accumulating sequence data, and thereby at inferring protein structure and function from sequence information alone. Recently, global statistical inference methods (e.g. direct-coupling analysis, sparse inverse covariance estimation) have achieved a breakthrough towards this aim, and their predictions have been successfully implemented into tertiary and quaternary protein structure prediction methods. However, due to the discrete nature of the underlying variable (amino-acids), exact inference requires exponential time in the protein length, and efficient approximations are needed for practical applicability. Here we propose a very efficient multivariate Gaussian modeling approach as a variant of direct-coupling analysis: the discrete amino-acid variables are replaced by continuous Gaussian random variables. The resulting statistical inference problem is efficiently and exactly solvable. We show that the quality of inference is comparable or superior to the one achieved by mean-field approximations to inference with discrete variables, as done by direct-coupling analysis. This is true for (i) the prediction of residue-residue contacts in proteins, and (ii) the identification of protein-protein interaction partner in bacterial signal transduction. An implementation of our multivariate Gaussian approach is available at the website http://areeweb.polito.it/ricerca/cmp/code.

  7. Monte Carlo simulation of the photoneutron field in linac radiotherapy treatments with different collimation systems.

    PubMed

    Zanini, A; Durisi, E; Fasolo, F; Ongaro, C; Visca, L; Nastasi, U; Burn, K W; Scielzo, G; Adler, J O; Annand, J R M; Rosner, G

    2004-02-21

    Bremsstrahlung photon beams produced by linac accelerators are currently the most commonly used method of radiotherapy for tumour treatments. When the photon energy exceeds 10 MeV the patient receives an undesired dose due to photoneutron production in the accelerator head. In the last few decades, new sophisticated techniques such as multileaf collimators have been used for a better definition of the target volume. In this case it is crucial to evaluate the photoneutron dose produced after giant dipole resonance (GDR) excitation of the high Z materials (mainly tungsten and lead) constituting the collimator leaves in view of the optimization of the radiotherapy treatment. A Monte Carlo approach has been used to calculate the photoneutron dose arising from the GDR reaction during radiotherapy with energetic photon beams. The simulation has been performed using the code MCNP4B-GN which is based on MCNP4B, but includes a new routine GAMMAN to model photoneutron production. Results for the facility at IRCC (Istituto per la Ricerca e la Cura del Cancro) Candiolo (Turin), which is based on 18 MV x-rays from a Varian Clinac 2300 C/D, are presented for a variety of different collimator configurations.

  8. Burning mouth syndrome: the role of contact hypersensitivity.

    PubMed

    Virgili, A; Corazza, M; Trombelli, L; Arcidiacono, A

    1996-11-01

    The burning mouth syndrome is characterized by an unpleasant sensation of burning in the oral cavity, without clinical signs. Causal factors may be psychogenic, systemic or local. The aim of the study was to determine the significance of contact allergy in the pathogenesis of burning mouth syndrome. Fifteen patients with burning mouth syndrome were studied through anamnesis and laboratory analysis. Epicutaneous patch tests were performed with the Italian standard series (GIRDCA - Gruppo Italiano di Ricerca Dermatiti da Contatto ed Ambientali), preservative and dental series. The same tests were carried out in 12 healthy age- and sex-matched subjects. The number of patients affected by burning mouth syndrome with a positive reaction to patchtesting was 6 out of 15, while the number of allergic patients in the control group was 3 out of 12. No association could be found between positive reaction at patchtesting and exposure to allergens. Contact allergy in burning mouth syndrome seems not to play a primary role; nevertheless, it is advisable to perform patch tests in selected patients to identify a possible aetiological agent.

  9. Round-robin pretest analyses of a 1:6-scale reinforced concrete containment model subject to static internal pressurization

    SciTech Connect

    Clauss, D.B.

    1987-05-01

    Analyses of a 1:6-scale reinforced concrete containment model that will be tested to failure at Sandia National Laboratories in the spring of 1987 were conducted by the following organizations in the United States and Europe: Sandia National Laboratories (USA), Argonne National Laboratory (USA), Electric Power Research Institute (USA), Commissariat a L'Energie Atomique (France), HM Nuclear Installations Inspectorate (UK), Comitato Nazionale per la ricerca e per lo sviluppo dell'Energia Nucleare e delle Energie Alternative (Italy), UK Atomic Energy Authority, Safety and Reliability Directorate (UK), Gesellschaft fuer Reaktorsicherheit (FRG), Brookhaven National Laboratory (USA), and Central Electricity Generating Board (UK). Each organization was supplied with a standard information package, which included construction drawings and actual material properties for most of the materials used in the model. Each organization worked independently using their own analytical methods. This report includes descriptions of the various analytical approaches and pretest predictions submitted by each organization. Significant milestones that occur with increasing pressure, such as damage to the concrete (cracking and crushing) and yielding of the steel components, and the failure pressure (capacity) and failure mechanism are described. Analytical predictions for pressure histories of strain in the liner and rebar and displacements are compared at locations where experimental results will be available after the test. Thus, these predictions can be compared to one another and to experimental results after the test.

  10. BaR-SPOrt: the instrument to be accommodated at Dome C

    NASA Astrophysics Data System (ADS)

    Zannoni, M.; Carretti, E.; Cortiglioni, S.; Macculi, C.; Ramponi, M.; Sbarra, C.; Ventura, G.; Monari, J.; Poloni, M.; Poppi, S.; Natale, V.; Nesti, R.; Baralis, M.; Peverini, O.; Tascone, R.; Virone, G.; Boscaleri, A.; Boella, G.; Sironi, G.; Gervasi, M.; de Bernardis, P.; Masi, S.; de Petris, M.

    The BaR-SPOrt (Balloon-Borne Radiometers for Sky Polarization Observations) experiment, a program of the Agenzia Spaziale Italiana (ASI) co-funded by PNRA (Progetto Nazionale di Ricerca in Antartide) was originally designed as a payload for long duration balloons flights. The changing scenario, both scientific and strategic, has led us to propose it for the starting winter campaign of at the Concordia Base. Here the instrument and the features making it suitable to operate at Dome-C are described. After the initial setup, BaR-SPOrt should not require any kind of routine intervention by a dedicated base staff. The experiment will just need electrical power (less than 2 kW) and a suitable accommodation on the field. It can be fully monitored and controlled, including the data acquisition, through its own telemetry/telecommand link using IRIDIUM modems. Both the receiver and the critical electronics are housed inside a temperature-controlled vacuum chamber, providing the properly stabilized environment. The cold part of the radiometer employs a closed loop mechanical cryo-cooler that provides temperatures <70 ±0.1 K with low power consumption (<200 W).

  11. The Mar Piccolo of Taranto: an interesting marine ecosystem for the environmental problems studies.

    PubMed

    Cardellicchio, Nicola; Annicchiarico, Cristina; Di Leo, Antonella; Giandomenico, Santina; Spada, Lucia

    2016-07-01

    The National Project RITMARE (la Ricerca ITaliana per il MARE-Italian Research for the sea) started from 1 January 2012. It is one of the national research programs funded by the Italian Ministry of University and Research. RITMARE is coordinated by the National Research Council (CNR) and involves an integrated effort of most of the scientific community working on marine and maritime issues. Within the project, different marine study areas of strategic importance for the Mediterranean have been identified: Among these, the coastal area of Taranto (Ionian Sea, Southern Italy) was chosen for its different industry settlements and the relative impact on the marine environment. In particular, the research has been concentrated on the Mar Piccolo of Taranto, a complex marine ecosystem model important in terms of ecological, social, and economic activities for the presence also of extensive mussel farms. The site has been selected also because the Mar Piccolo area is a characteristic "on field" laboratory suitable to investigate release and diffusion mechanisms of contaminants, evaluate chemical-ecological risks towards the marine ecosystem and human health, and suggest and test potential remediation strategies for contaminated sediments. In this context, within the project RITMARE, a task force of researchers has contributed to elaboration a functioning conceptual model with a multidisciplinary approach useful to identify anthropogenic forcings, its impacts, and solutions of environmental remediation. This paper describes in brief some of the environmental issues related to the Mar Piccolo basin.

  12. The Italian Cloud-based brokering Infrastructure to sustain Interoperability for Operative Hydrology

    NASA Astrophysics Data System (ADS)

    Boldrini, E.; Pecora, S.; Bussettini, M.; Bordini, F.; Nativi, S.

    2015-12-01

    This work presents the informatics platform carried out to implement the National Hydrological Operative Information System of Italy. In particular, the presentation will focus on the governing aspects of the cloud infrastructure and brokering software that make possible to sustain the hydrology data flow between heterogeneous user clients and data providers.The Institute for Environmental Protection and Research, ISPRA (Istituto Superiore per la Protezione e la Ricerca Ambientale) in collaboration with the Regional Agency for Environmental Protection in the Emilia-Romagna region, ARPA-ER (Agenzia Regionale per la Prevenzione e l´Ambiente dell´Emilia-Romagna) and CNR-IIA (National Research Council of Italy) designed and developed an innovative platform for the discovery and access of hydrological data coming from 19 Italian administrative regions and 2 Italian autonomous provinces, in near real time. ISPRA has deployed and governs such a system. The presentation will introduce and discuss the technological barriers for interoperability as well as social and policy ones. The adopted solutions will be described outlining the sustainability challenges and benefits.

  13. Floral homeotic genes are targets of gibberellin signaling in flower development.

    PubMed

    Yu, Hao; Ito, Toshiro; Zhao, Yuanxiang; Peng, Jinrong; Kumar, Prakash; Meyerowitz, Elliot M

    2004-05-18

    Gibberellins (GAs) are a class of plant hormones involved in the regulation of flower development in Arabidopsis. The GA-deficient ga1-3 mutant shows retarded growth of all floral organs, especially abortive stamen development that results in complete male sterility. Until now, it has not been clear how GA regulates the late-stage development of floral organs after the establishment of their identities within floral meristems. Various combinations of null mutations of DELLA proteins can gradually rescue floral defects in ga1-3. In particular, the synergistic effect of rga-t2 and rgl2-1 can substantially restore flower development in ga1-3. We find that the transcript levels of floral homeotic genes APETALA3 (AP3), PISTILLATA (PI), and AGAMOUS (AG) are immediately upregulated in young flowers of ga1-3 upon GA treatment. Using a steroid-inducible activation of RGA, we further demonstrated that these floral homeotic genes are transcriptionally repressed by RGA activity in young flowers whereas the expression of LEAFY (LFY) and APETALA1 (AP1) is not substantially affected. In addition, we observed the partial rescue of floral defects in ga1-3 by overexpression of AG. Our results indicate that GA promotes the expression of floral homeotic genes by antagonizing the effects of DELLA proteins, thereby allowing continued flower development.

  14. Phylogenetic analysis of GRAS proteins from moss, lycophyte and vascular plant lineages reveals that GRAS genes arose and underwent substantial diversification in the ancestral lineage common to bryophytes and vascular plants

    PubMed Central

    2011-01-01

    GRAS genes are a large family of streptophyte specific transcription factors that function in a diverse set of physiological and developmental processes. GRAS proteins of the HAIRY MERISTEM (HAM) sub-family are required for maintenance of shoot and root indeterminacy. The transcriptional targets of HAM proteins and the signaling inputs regulating HAM activity are completely unknown. Understanding the relationship of HAM proteins to other members of the GRAS family may inform hypotheses relating to cellular level HAM functions. Here I report a phylogenetic analysis of GRAS proteins employing the complete set of known and probable GRAS proteins from the sequenced genomes of the flowering plants Arabidopsis and Rice, the lycophyte Selaginella moellendorffii, and the bryophyte Physcomitrella patens. HAM proteins are most closely related to DELLA proteins, key components of gibberellin perception. However, GRAS proteins diversified into a minimum of 12 discreet monophyletic lineages, including the HAM and DELLA subfamilies, prior to divergence of the moss and flowering plant lineages. Substantial diversification of GRAS proteins at so early a point in land plant evolution suggests that relative relatedness among GRAS protein sub-families may not substantially reflect shared protein function. PMID:21543899

  15. Thermokarst, mantling and Late Amazonian Epoch periglacial-revisions in the Argyre region, Mars

    NASA Astrophysics Data System (ADS)

    Soare, R. J.; Baoini, D.; Conway, S. J.; Dohm, J. M.; Kargel, J. S.

    2015-10-01

    Thermokarst, mantling and Late Amazonian Epoch periglacial-revisions in the Argyre region, Mars R.J. Soare(1), D. Baioni(2), S.J. Conway (3), J.M. Dohm(4)and J.S. Kargel (5)(1) Geography Department, Dawson College, Montreal, Canada H3Z 1A4 rsoare@dawsoncollege.qc.ca.(2) Dipartimento di Scienze della Terra,della Vita e Ambiente, Università di Urbino "Carlo Bo", Campus SOGESTA, 61029 Urbino (PU) Italy. (3) Department of Physical Sciences, Open University, Milton Keynes, United Kingdom, MK7 6AA. (4) The University Museum, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-, Japan.(5) Department of Hydrology & Water Resources, University of Arizona, Tucson, Arizona, USA 85719.1.Introduction Metre to decametre-deep depressions that are rimless, relatively flat-floored, polygonised and scallop-shaped have been widely observed in Utopia Planitia (UP) [e.g. 1-5] and Malea Planum (MP) [6-8]. Although there is some debate about whether the depressions formed by means of sublimation or evaporation, it is commonly believed that the terrain in which the depressions occur is ice-rich.Moreover, most workers assume that this "ice-richness" is derived of a bi-hemispheric, latitudinally-dependent and atmospherically-precipitated mantle that is metres thick [2,4,6-10].

  16. Surgical strategies for cutaneous neoplasm of the scalp. State of art.

    PubMed

    Vitagliano, Tiziana; Greco, Manfredi; Dessy, Luca Andrea; Atzeni, Matteo; Ciriaco, Antonio Greto; Ribuffo, Diego

    2015-01-01

    La ricostruzione dello scalpo è sempre stato un compito arduo ed una sfida, in particolare dopo una demolizione oncologica, e questo articolo offre una visione globale dello stato dell’arte sulle strategie ricostruttive. A questo scopo abbiamo elaborato un algoritmo sistematico per la ricostruzione dello scalpo basato sulla sede e l’estensione del difetto, la presenza o meno del periostio, il coinvolgimento osseo, la qualità dello scalpo circostante, la presenza o meno dei capelli, la localizzazione della linea del capillifero, le comorbilità del paziente e le differenti procedure comunemente usate in chirurgia plastica. Come risultato il nostro algoritmo consente ai chirurghi plastici di procedere alla ricostruzione dello scalpo dopo i difetti più devastanti, ed il successo della ricostruzione richiede una attenta pianificazione preoperatoria ed un approfondita conoscenza dell’anatomia dello scalpo, la fisiologia dei capelli, la varietà dei tessuti localmente disponibili e le procedure di chirurgia plastica, come pure la conoscenza dei sostituiti sintetici e dei prodotti forniti dall’ingegneria tissutale. La sfida attuale è comunque quella di ottenere risultati cosmetici di eccellenza, di cui sono esempio i cinque casi dell’iconografia.

  17. Klamath Mountains Ecoregion: Chapter 13 in Status and trends of land change in the Western United States--1973 to 2000

    USGS Publications Warehouse

    Sleeter, Benjamin M.; Calzia, James P.

    2012-01-01

    The Klamath Mountains Ecoregion covers approximately 47,791 km2 (18,452 mi2) of the Klamath and Siskiyou Mountains of northern California and southern Oregon (fig. 1) (Omernik, 1987; U.S. Environmental Protection Agency, 1997). The ecoregion is flanked by the Coast Range Ecoregion to the west, the Southern and Central California Chaparral and Oak Woodlands Ecoregion to the south, the Cascades and the Eastern Cascades Slopes and Foothills Ecoregions to the east, and the Willamette Valley Ecoregion to the north. The mild Mediterranean climate of the ecoregion is characterized by hot, dry summers and wet winters; the amount of winter moisture varies within the ecoregion, decreasing from west to east. The Klamath–Siskiyou Mountains region is widely recognized as an important biodiversity hotspot (Whittaker, 1960; Kruckeberg, 1984; Wagner, 1997; DellaSala and others, 1999), containing more than 3,500 plant species, more than 200 of which are endemic (Sawyer, 2007). A biological assessment by DellaSala and others (1999) ranked the Klamath–Siskiyou Mountains region as the fifth richest coniferous forest in terms of species diversity. In addition, the International Union for the Conservation of Nature considers the region an area of notable botanical importance (Wagner, 1997). Twenty-nine different species of conifers can be found in the Klamath Mountains Ecoregion (Sawyer, 1996).

  18. Pneumatic positioning and mesh fixation in laparoscopic ventral/incisional hernia repair. New surgical technique and a new device.

    PubMed

    Darecchio, Antonio; Bocchi, Paolo; Kukleta, Jan F

    2015-01-01

    Oggetto di questa pubblicazione è la descrizione di una nuova tecnica chirurgica per la riparazione videolaparoscopica di laparoceli ed ernie della parete addominale anteriore. Tale tecnica è strettamente dipendente dall’utilizzo di un nuovo strumento pneumatico per il posizionamento della protesi. Attualmente esistono in commercio svariati tipi di protesi intraperitoneali con valide caratteristiche strutturali. Tuttavia lo scoglio concettuale rimane sui metodi e sui mezzi di fissaggio delle protesi. I mezzi meccanici di qualsiasi conformazione per il fatto stesso di essere dei mezzi meccanici (spirali metalliche ancorette e viti) espongono al pericolo di danno iatrogeno le strutture vascolari nervose che possono incontrare nel loro percorso. La nuova tecnica proposta mira alla perfetta distensione delle protesi per utilizzo intraperitoneale ed ai loro ottimale fissaggio con adesivo chirurgico in condizioni di sicurezza per le strutture circostanti. Tale tecnica è stata eseguita su cadavere di suino* con protesi intraperitoneali di poliestere-gel-collageno e cyanoacrylate come adesivo chirurgico ma non è esclusa la fattibilità con altri tipi di colle, di protesi, protesi auto-adesive già esistenti in commercio o che potrebbero essere appositamente prodotte.

  19. Functional characterization of the apple MhGAI1 gene through ectopic expression and grafting experiments in tomatoes.

    PubMed

    Wang, Shuang-Shuang; Liu, Ze-Zhou; Sun, Chao; Shi, Qing-Hua; Yao, Yu-Xin; You, Chun-Xiang; Hao, Yu-Jin

    2012-02-15

    DELLA proteins are essential components of GA signal transduction. MhGAI1 was isolated from the tea crabapple (Malus hupehensis Redh. var. pingyiensis), and it was found to encode a DELLA protein. Mhgai1 is a GA-insensitive allele that was artificially generated via a bridge-PCR approach. Ectopic expression of Mhgai1 reduced plant stature, decreased spontaneous fruit-set-ratio and enhanced drought-tolerance in transgenic tomatoes. In addition, we examined the long-distance movement of Mhgai1 mRNAs by grafting experiments and SqRT-PCR analysis. It was found that the wild-type scions accumulated Mhgai1 transcripts trafficked from the transgenic rootstocks and therefore exhibited dwarf phenotypes. Furthermore, transgenic tomato plants produced more soluble solids, sugars and organic acids compared to wild-type tomatoes, suggesting an involvement of GA signaling in the regulation of fruit quality. Despite noticeable accumulation in the leaves and stems of WT scions, Mhgai1 transcripts were undetectable in flowers and fruit. Therefore, fruit quality was less influenced by the grafting of WT scions onto transgenic rootstocks than they were by the ectopic expression of Mhgai1 in transgenic rootstocks. Taken together, MhGAI1, which functions as a repressor in the GA signaling pathway, and its GA-insensitive allele, Mhgai1, could turn out to be useful targets for the genetic improvement of dwarfing rootstocks in apples.

  20. The Arabidopsis C2H2 zinc finger INDETERMINATE DOMAIN1/ENHYDROUS promotes the transition to germination by regulating light and hormonal signaling during seed maturation.

    PubMed

    Feurtado, J Allan; Huang, Daiqing; Wicki-Stordeur, Leigh; Hemstock, Laura E; Potentier, Mireille S; Tsang, Edward W T; Cutler, Adrian J

    2011-05-01

    Seed development ends with a maturation phase that imparts desiccation tolerance, nutrient reserves, and dormancy degree. Here, we report the functional analysis of an Arabidopsis thaliana C2H2 zinc finger protein INDETERMINATE DOMAIN1 (IDD1)/ENHYDROUS (ENY). Ectopic expression of IDD1/ENY (2x35S:ENY) disrupted seed development, delaying endosperm depletion and testa senescence, resulting in an abbreviated maturation program. Consequently, mature 2x35S:ENY seeds had increased endosperm-specific fatty acids, starch retention, and defective mucilage extrusion. Using RAB18 promoter ENY lines (RAB18:ENY) to confine expression to maturation, when native ENY expression increased and peaked, resulted in mature seed with lower abscisic acid (ABA) content and decreased germination sensitivity to applied ABA. Furthermore, results of far-red and red light treatments of 2x35S:ENY and RAB18:ENY germinating seeds, and of artificial microRNA knockdown lines, suggest that ENY acts to promote germination. After using RAB18:ENY seedlings to induce ENY during ABA application, key genes in gibberellin (GA) metabolism and signaling were differentially regulated in a manner suggesting negative feedback regulation. Furthermore, GA treatment resulted in a skotomorphogenic-like phenotype in light-grown 2x35S:ENY and RAB18:ENY seedlings. The physical interaction of ENY with DELLAs and an ENY-triggered accumulation of DELLA transcripts during maturation support the conclusion that ENY mediates GA effects to balance ABA-promoted maturation during late seed development.