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Sample records for euclidean correlators volume

  1. One-dimensional Euclidean matching problem: exact solutions, correlation functions, and universality.

    PubMed

    Caracciolo, Sergio; Sicuro, Gabriele

    2014-10-01

    We discuss the equivalence relation between the Euclidean bipartite matching problem on the line and on the circumference and the Brownian bridge process on the same domains. The equivalence allows us to compute the correlation function and the optimal cost of the original combinatorial problem in the thermodynamic limit; moreover, we solve also the minimax problem on the line and on the circumference. The properties of the average cost and correlation functions are discussed.

  2. Studies in Mathematics, Volume II. Euclidean Geometry Based on Ruler and Protractor Axioms. Second Revised Edition.

    ERIC Educational Resources Information Center

    Curtis, Charles W.; And Others

    These materials were developed to help high school teachers to become familiar with the approach to tenth-grade Euclidean geometry which was adopted by the School Mathematics Study Group (SMSG). It is emphasized that the materials are unsuitable as a high school textbook. Each document contains material too difficult for most high school students.…

  3. Volume holographic wavelet correlation processor

    NASA Astrophysics Data System (ADS)

    Feng, Wenyi; Yan, Yingbai; Jin, Guofan; Wu, Minxian; He, Qingsheng

    2000-09-01

    A volume holographic wavelet correlation processor is proposed and constructed for correlation identification. It is based on the theory of wavelet transforms and the mechanism of angle-multiplexing volume holographic associative storage in a photorefractive crystal. High parallelism and discrimination are achieved with the system. Our research shows that cross-talk noise is significantly reduced with wavelet filtering preprocessing. Correlation outputs can be expanded from one dimension in a conventional system to two dimensions in our system. As a result, the parallelism is greatly enhanced. Furthermore, several advantages of wavelet transforms in improving the discrimination capability of the system are described. The conventional correlation between two images is replaced by wavelet correlation between main local features extracted by an appropriate wavelet filter, which provides a sharp peak with low sidelobes. Theoretical analysis and experimental results are both given to support our conclusions. Its preliminary application to human-face recognition is studied.

  4. Correspondence Principle Between Spherical and Euclidean Wavelets, and Fast Directional Correlation on the Sphere With Steerable Filters

    NASA Astrophysics Data System (ADS)

    Wiaux, Y.; Jacques, L.; Vandergheynst, P.

    2005-12-01

    Wavelets on the sphere are reintroduced and further developed on both the theoretical and the algorithmic grounds. A specific application to cosmology is also discussed. First, a new practical approach to the wavelet filtering of signals on the sphere is developed. Translations and rotations of the filters are naturally implemented through three-dimensional rotations of the group SO(3), and a unitary, radial, and conformal dilation operator is required. The resulting formalism is unique. A correspondence principle is also established, stating that the inverse stereographic projection of a wavelet on the plane (i.e., Euclidean wavelet) also uniquely leads to a wavelet on the sphere (i.e., spherical wavelet). It simplifies the construction of wavelets on the sphere and allows the transfer onto the sphere of properties of wavelets on the plane, such as directionality and steerability. Second, an exact fast algorithm is developed for the directional correlation on the sphere of band-limited signals of band limit L and steerable (wavelet) filters, on 2L×2L equi-angular grids in the coordinates (θ,φ). On the one hand, the algorithm is based on a technique of separation of variables in the Wigner D-functions, basis functions for the harmonic analysis on the rotation group SO(3). The asymptotic complexity of the algorithm is correspondingly reduced from O(L5) to O(L4). On the other hand, the filter steerability and the use of the Driscoll and Healy fast scalar spherical harmonics transform further reduce the algorithm complexity to a simple O(L2log22L). Finally, we consider the perspective of the wavelet analysis of the cosmic microwave background (CMB) temperature and polarization anisotropies on the sphere of the sky. The notions of directionality and steerability are important tools for the identification of local directional features in the wavelet coefficients of the signal, and for their interpretation in cosmology. In this context, computation times for the exact

  5. Imbedding Locally Euclidean and Conformally Euclidean Metrics

    NASA Astrophysics Data System (ADS)

    Aleksandrov, V. A.

    1992-02-01

    The possibility of imbedding n-dimensional locally Euclidean metrics in the large in Rn is studied by means of the global inverse function theorem in the forms suggested by Hadamard, John, Levy and Plastock. The imbeddability of conformally Euclidean metrics is studied by means of a theorem of Zorich on the removability of an isolated singularity of a locally quasiconformal mapping.

  6. The Development of Euclidean and Non-Euclidean Cosmologies

    ERIC Educational Resources Information Center

    Norman, P. D.

    1975-01-01

    Discusses early Euclidean cosmologies, inadequacies in classical Euclidean cosmology, and the development of non-Euclidean cosmologies. Explains the present state of the theory of cosmology including the work of Dirac, Sandage, and Gott. (CP)

  7. The Development of Euclidean and Non-Euclidean Cosmologies

    ERIC Educational Resources Information Center

    Norman, P. D.

    1975-01-01

    Discusses early Euclidean cosmologies, inadequacies in classical Euclidean cosmology, and the development of non-Euclidean cosmologies. Explains the present state of the theory of cosmology including the work of Dirac, Sandage, and Gott. (CP)

  8. Euclidean black hole vortices

    NASA Technical Reports Server (NTRS)

    Dowker, Fay; Gregory, Ruth; Traschen, Jennie

    1991-01-01

    We argue the existence of solutions of the Euclidean Einstein equations that correspond to a vortex sitting at the horizon of a black hole. We find the asymptotic behaviors, at the horizon and at infinity, of vortex solutions for the gauge and scalar fields in an abelian Higgs model on a Euclidean Schwarzschild background and interpolate between them by integrating the equations numerically. Calculating the backreaction shows that the effect of the vortex is to cut a slice out of the Schwarzschild geometry. Consequences of these solutions for black hole thermodynamics are discussed.

  9. Multiplexing of volume holographic wavelet correlation processor

    NASA Astrophysics Data System (ADS)

    Feng, Wenyi; Yan, Yingbai; Jin, Guofan; Wu, Minxian; He, Qingsheng

    2000-03-01

    Volume holographic associative memory in a photorefractive crystal provides an inherent mechanism to develop a multi-channel correlation identification system with high parallelism. Wavelet transform is introduced to improve discrimination of the system. We first investigate parameters of the system for parallelism enhancement, and then study multiplexing of the system on input objects and wavelet filters. A general volume holographic wavelet correlation processor has a single input-object channel and a single wavelet-filtering channel. In other words, it can only process one input object with one wavelet filter at a same time. Based on the fact that a volume holographic correlator is not a shift-invariant system, multiplexing of input objects is proposed to improve parallelism of the processor. As a result, several input objects can be recognized simultaneously. Multiplexing of wavelet filters with different wavelet parameters is also achieved by a Dammann grating. Wavelet correlation outputs with different filters are synthesized to improve recognition accuracy of the processor. Corresponding experimental results in human face recognition are given. The combination of the input object multiplexing and the wavelet filter multiplexing is also described.

  10. Enjoyment of Euclidean Planar Triangles

    ERIC Educational Resources Information Center

    Srinivasan, V. K.

    2013-01-01

    This article adopts the following classification for a Euclidean planar [triangle]ABC, purely based on angles alone. A Euclidean planar triangle is said to be acute angled if all the three angles of the Euclidean planar [triangle]ABC are acute angles. It is said to be right angled at a specific vertex, say B, if the angle ?ABC is a right angle…

  11. Non-Euclidean spring embedders.

    PubMed

    Kobourov, Stephen G; Wampler, Kevin

    2005-01-01

    We present a conceptually simple approach to generalizing force-directed methods for graph layout from Euclidean geometry to Riemannian geometries. Unlike previous work on non-Euclidean force-directed methods, ours is not limited to special classes of graphs, but can be applied to arbitrary graphs. The method relies on extending the Euclidean notions of distance, angle, and force-interactions to smooth non-Euclidean geometries via projections to and from appropriately chosen tangent spaces. In particular, we formally describe the calculations needed to extend such algorithms to hyperbolic and spherical geometries. We also study the theoretical and practical considerations that arise when working with non-Euclidean geometries.

  12. Non-Hermitian Euclidean random matrix theory.

    PubMed

    Goetschy, A; Skipetrov, S E

    2011-07-01

    We develop a theory for the eigenvalue density of arbitrary non-Hermitian Euclidean matrices. Closed equations for the resolvent and the eigenvector correlator are derived. The theory is applied to the random Green's matrix relevant to wave propagation in an ensemble of pointlike scattering centers. This opens a new perspective in the study of wave diffusion, Anderson localization, and random lasing.

  13. Proceedings of RIKEN BNL Research Center Workshop: Understanding QGP through Spectral Functions and Euclidean Correlators (Volume 89)

    SciTech Connect

    Mocsy,A.; Petreczky, P.

    2008-06-27

    In the past two decades, one of the most important goals of the nuclear physics community has been the production and characterization of the new state of matter--Quark-Gluon Plasma (QGP). Understanding how properties of hadrons change in medium, particularly, the bound state of a very heavy quark and its antiquark, known as quarkonium, as well as determining the transport coefficients is crucial for identifying the properties of QGP and for the understanding of the experimental data from RHIC. On April 23rd, more than sixty physicists from twenty-seven institutions gathered for this three-day topical workshop held at BNL to discuss how to understand the properties of the new state of matter obtained in ultra-relativistic heavy ion collisions (particularly at RHIC-BNL) through spectral functions. In-medium properties of the different particle species and the transport properties of the medium are encoded in spectral functions. The former could yield important signatures of deconfinement and chiral symmetry restoration at high temperatures and densities, while the later are crucial for the understanding of the dynamics of ultra-relativistic heavy ion collisions. Participants at the workshop are experts in various areas of spectral function studies. The workshop encouraged direct exchange of scientific information among experts, as well as between the younger and the more established scientists. The workshops success is evident from the coherent picture that developed of the current understanding of transport properties and in-medium particle properties, illustrated in the current proceedings. The following pages show calculations of meson spectral functions in lattice QCD, as well as implications of these for quarkonia melting/survival in the quark gluon plasma; Lattice calculations of the transport coefficients (shear and bulk viscosities, electric conductivity); Calculation of spectral functions and transport coefficients in field theories using weak coupling techniques; And certain spectral functions and also the heavy quark diffusion constant have been calculated in the strongly coupled limit of the N = 4 super-symmetric Yang Mills theory.

  14. Cross-correlations in volume space: Differences between buy and sell volumes

    NASA Astrophysics Data System (ADS)

    Lee, Sun Young; Hwang, Dong Il; Kim, Min Jae; Koh, In Gyu; Kim, Soo Yong

    2011-03-01

    We study the cross-correlations of buy and sell volumes on the Korean stock market in high frequency. We observe that the pulling effects of volumes are as small as that of returns. The properties of the correlations of buy and sell volumes differ. They are explained by the degree of synchronization of stock volumes. Further, the pulling effects on the minimal spanning tree are studied. In minimal spanning trees with directed links, the large pulling effects are clustered at the center, not uniformly distributed. The Epps effect of buy and sell volumes are observed. The reversal of the cross-correlations of buy and sell volumes is also detected.

  15. Correlation of ultrasound estimated placental volume and umbilical cord blood volume in term pregnancy

    PubMed Central

    Pannopnut, Papinwit; Kitporntheranunt, Maethaphan; Paritakul, Panwara; Kongsomboon, Kittipong

    2015-01-01

    Objective To investigate the correlation between ultrasound measured placental volume and collected umbilical cord blood (UCB) volume in term pregnancy. Material and Methods An observational cross-sectional study of term singleton pregnant women in the labor ward at Maha Chakri Sirindhorn Medical Center was conducted. Placental thickness, height, and width were measured using two-dimensional (2D) ultrasound and calculated for placental volume using the volumetric mathematic model. After the delivery of the baby, UCB was collected and measured for its volume immediately. Then, birth weight, placental weight, and the actual placental volume were analyzed. The Pearson’s correlation was used to determine the correlation between each two variables. Results A total of 35 pregnant women were eligible for the study. The mean and standard deviation of estimated placental volume and actual placental volume were 534±180 mL and 575±118 mL, respectively. The median UCB volume was 140 mL (range 98–220 mL). The UCB volume did not have a statistically significant correlation with the estimated placental volume (correlation coefficient 0.15; p=0.37). However, the UCB volume was significantly correlated with the actual placental volume (correlation coefficient 0.62; p<0.001) and birth weight (correlation coefficient 0.38; p=0.02). Conclusion The estimated placental volume by 2D ultrasound was not significantly correlated with the UCB volume. Further studies to establish the correlation between the UCB volume and the estimated placental volume using other types of placental imaging may be needed. PMID:26097385

  16. Euclidean Epstein-Glaser renormalization

    SciTech Connect

    Keller, Kai J.

    2009-10-15

    In the framework of perturbative algebraic quantum field theory recently developed by Brunetti, Duetsch, and Fredenhagen (http://arxiv.org/abs/0901.2038) I give a general construction of so-called Euclidean time-ordered products, i.e., algebraic versions of the Schwinger functions, for scalar quantum field theories on spaces of Euclidean signature. This is done by generalizing the recursive construction of time-ordered products by Epstein and Glaser, originally formulated for quantum field theories on Minkowski space [Epstein and Glaser, Ann. Inst. Henri Poincare 19, 211 (1973)]. An essential input of Epstein-Glaser renormalization is the causal structure of Minkowski space. The absence of this causal structure in the Euclidean framework makes it necessary to modify the original construction of Epstein and Glaser at two points. First, the whole construction has to be performed with an only partially defined product on (interaction) functionals. This is due to the fact that the fundamental solutions of the Helmholtz operator (-{delta}+m{sup 2}) of Euclidean quantum field theory have a unique singularity structure, i.e., they are unique up to a smooth part. Second, one needs to (re)introduce a (rather natural) 'Euclidean causality' condition for the recursion of Epstein and Glaser to be applicable.

  17. Euclidean Epstein-Glaser renormalization

    NASA Astrophysics Data System (ADS)

    Keller, Kai J.

    2009-10-01

    In the framework of perturbative algebraic quantum field theory recently developed by Brunetti, Dütsch, and Fredenhagen (http://arxiv.org/abs/0901.2038) I give a general construction of so-called Euclidean time-ordered products, i.e., algebraic versions of the Schwinger functions, for scalar quantum field theories on spaces of Euclidean signature. This is done by generalizing the recursive construction of time-ordered products by Epstein and Glaser, originally formulated for quantum field theories on Minkowski space [Epstein and Glaser, Ann. Inst. Henri Poincare 19, 211 (1973)]. An essential input of Epstein-Glaser renormalization is the causal structure of Minkowski space. The absence of this causal structure in the Euclidean framework makes it necessary to modify the original construction of Epstein and Glaser at two points. First, the whole construction has to be performed with an only partially defined product on (interaction) functionals. This is due to the fact that the fundamental solutions of the Helmholtz operator (-Δ+m2) of Euclidean quantum field theory have a unique singularity structure, i.e., they are unique up to a smooth part. Second, one needs to (re)introduce a (rather natural) "Euclidean causality" condition for the recursion of Epstein and Glaser to be applicable.

  18. Correlation of Magnetic Resonance Imaging Tumor Volume with Histopathology

    PubMed Central

    Turkbey, Baris; Mani, Haresh; Aras, Omer; Rastinehad, Ardeshir R.; Shah, Vijay; Bernardo, Marcelino; Pohida, Thomas; Daar, Dagane; Benjamin, Compton; McKinney, Yolanda L.; Linehan, W. Marston; Wood, Bradford J.; Merino, Maria J.; Choyke, Peter L.; Pinto, Peter A.

    2017-01-01

    Purpose The biology of prostate cancer may be influenced by the index lesion. The definition of index lesion volume is important for appropriate decision making, especially for image guided focal treatment. We determined the accuracy of magnetic resonance imaging for determining index tumor volume compared with volumes derived from histopathology. Materials and Methods We evaluated 135 patients (mean age 59.3 years) with a mean prostate specific antigen of 6.74 ng/dl who underwent multiparametric 3T endorectal coil magnetic resonance imaging of the prostate and subsequent radical prostatectomy. Index tumor volume was determined prospectively and independently by magnetic resonance imaging and histopathology. The ellipsoid formula was applied to determine histopathology tumor volume, whereas manual tumor segmentation was used to determine magnetic resonance tumor volume. Histopathology tumor volume was correlated with age and prostate specific antigen whereas magnetic resonance tumor volume involved Pearson correlation and linear regression methods. In addition, the predictive power of magnetic resonance tumor volume, prostate specific antigen and age for estimating histopathology tumor volume (greater than 0.5 cm3) was assessed by ROC analysis. The same analysis was also conducted for the 1.15 shrinkage factor corrected histopathology data set. Results There was a positive correlation between histopathology tumor volume and magnetic resonance tumor volume (Pearson coefficient 0.633, p <0.0001), but a weak correlation between prostate specific antigen and histopathology tumor volume (Pearson coefficient 0.237, p=0.003). On linear regression analysis histopathology tumor volume and magnetic resonance tumor volume were correlated (r2=0.401, p <0.00001). On ROC analysis AUC values for magnetic resonance tumor volume, prostate specific antigen and age in estimating tumors larger than 0.5 cm3 at histopathology were 0.949 (p <0.0000001), 0.685 (p=0.001) and 0.627 (p=0

  19. Correlation of magnetic resonance imaging tumor volume with histopathology.

    PubMed

    Turkbey, Baris; Mani, Haresh; Aras, Omer; Rastinehad, Ardeshir R; Shah, Vijay; Bernardo, Marcelino; Pohida, Thomas; Daar, Dagane; Benjamin, Compton; McKinney, Yolanda L; Linehan, W Marston; Wood, Bradford J; Merino, Maria J; Choyke, Peter L; Pinto, Peter A

    2012-10-01

    The biology of prostate cancer may be influenced by the index lesion. The definition of index lesion volume is important for appropriate decision making, especially for image guided focal treatment. We determined the accuracy of magnetic resonance imaging for determining index tumor volume compared with volumes derived from histopathology. We evaluated 135 patients (mean age 59.3 years) with a mean prostate specific antigen of 6.74 ng/dl who underwent multiparametric 3T endorectal coil magnetic resonance imaging of the prostate and subsequent radical prostatectomy. Index tumor volume was determined prospectively and independently by magnetic resonance imaging and histopathology. The ellipsoid formula was applied to determine histopathology tumor volume, whereas manual tumor segmentation was used to determine magnetic resonance tumor volume. Histopathology tumor volume was correlated with age and prostate specific antigen whereas magnetic resonance tumor volume involved Pearson correlation and linear regression methods. In addition, the predictive power of magnetic resonance tumor volume, prostate specific antigen and age for estimating histopathology tumor volume (greater than 0.5 cm(3)) was assessed by ROC analysis. The same analysis was also conducted for the 1.15 shrinkage factor corrected histopathology data set. There was a positive correlation between histopathology tumor volume and magnetic resonance tumor volume (Pearson coefficient 0.633, p <0.0001), but a weak correlation between prostate specific antigen and histopathology tumor volume (Pearson coefficient 0.237, p = 0.003). On linear regression analysis histopathology tumor volume and magnetic resonance tumor volume were correlated (r(2) = 0.401, p <0.00001). On ROC analysis AUC values for magnetic resonance tumor volume, prostate specific antigen and age in estimating tumors larger than 0.5 cm(3) at histopathology were 0.949 (p <0.0000001), 0.685 (p = 0.001) and 0.627 (p = 0.02), respectively. Similar

  20. Correlations between elastic moduli and molar volume in metallic glasses

    NASA Astrophysics Data System (ADS)

    Wang, J. Q.; Wang, W. H.; Yu, H. B.; Bai, H. Y.

    2009-03-01

    We report clear correlations between bulk modulus (K) and average molar volume Vm, and between Poisson's ratio ν and Vm for various bulk metallic glasses. The origin for the correlations between elastic moduli and Vm are discussed. The established correlation, associated with Poisson's ratio ν, and since the ν correlates with plasticity of metallic glasses, indicates that the average molar volume is important factor to be considered for plastic metallic glasses searching. The found correlations also suggest a close relation between the mechanical properties and the short-range atomic bonding, and assist in understanding deformation behavior in metallic glasses.

  1. Euclidean, Spherical, and Hyperbolic Shadows

    ERIC Educational Resources Information Center

    Hoban, Ryan

    2013-01-01

    Many classical problems in elementary calculus use Euclidean geometry. This article takes such a problem and solves it in hyperbolic and in spherical geometry instead. The solution requires only the ability to compute distances and intersections of points in these geometries. The dramatically different results we obtain illustrate the effect…

  2. Euclidean, Spherical, and Hyperbolic Shadows

    ERIC Educational Resources Information Center

    Hoban, Ryan

    2013-01-01

    Many classical problems in elementary calculus use Euclidean geometry. This article takes such a problem and solves it in hyperbolic and in spherical geometry instead. The solution requires only the ability to compute distances and intersections of points in these geometries. The dramatically different results we obtain illustrate the effect…

  3. Enjoyment of Euclidean planar triangles

    NASA Astrophysics Data System (ADS)

    Srinivasan, V. K.

    2013-09-01

    This article adopts the following classification for a Euclidean planar ?, purely based on angles alone. A Euclidean planar triangle is said to be acute angled if all the three angles of the Euclidean planar ? are acute angles. It is said to be right angled at a specific vertex, say B, if the angle ? is a right angle with the two remaining angles as acute angles. It is said to be obtuse angled at the vertex B if ? is an obtuse angle, with the two remaining angles as acute angles. In spite of the availability of numerous text books that contain our human knowledge of Euclidean plane geometry, softwares can offer newer insights about the characterizations of planar geometrical objects. The author's characterizations of triangles involve points like the centroid G, the orthocentre H of the ?, the circumcentre S of the ?, the centre N of the nine-point circle of the ?. Also the radical centre rc of three involved diameter circles of the sides BC, AC and AB of the ? provides a reformulation of the orthocentre, resulting in an interesting theorem, dubbed by the author as 'Three Circles Theorem'. This provides a special result for a right-angled ?, again dubbed by the author as 'The Four Circles Theorem'. Apart from providing various inter connections between the geometrical points, the relationships between shapes of the triangle and the behaviour of the points are reasonably explored in this article. Most of these results will be useful to students that take courses in Euclidean Geometry at the college level and the high school level. This article will be useful to teachers in mathematics at the high school level and the college level.

  4. Euclidean Circles and Their Modular Images.

    ERIC Educational Resources Information Center

    Austin, Joe Dan

    1990-01-01

    Shows a series of Euclidean equations using the Euclidean algorithm to get the greatest common divisor of two integers. Describes the use of the equations to generate a series of circles. Discusses computer generation of Euclidean circles and provides a BASIC program. (YP)

  5. Volume holographic wavelet correlators with multi-input channels

    NASA Astrophysics Data System (ADS)

    Feng, Wenyi; Yan, Yingbai; Jin, Guofan; Wu, Minxian; He, Qingsheng

    1999-10-01

    Optical correlators based on volume holographic associative storage and wavelet matched filtering generally have single input channel. In other words, they can only process one input image at a same time. Based on the fact that a volume holographic correlator is not a shift invariance system, novel volume holographic wavelet correlators with multi- input channels are proposed and constructed in this paper to improve the parallelism of processing. Without adding any component, the method of input plane shifting and the technique of angle multiplexing are combined besides the introduction of wavelet transform. With the correlators, several input images can be recognized simultaneously according to a same system output. Conditions of realizing multi-input channel processing are studied in this paper. The mechanism and prototype of the system are described in detail. The performance of the system in human face recognition is testified by experiment. Promising results are given.

  6. Nonperturbative aspects of Euclidean Yang-Mills theories in linear covariant gauges: Nielsen identities and a BRST-invariant two-point correlation function

    NASA Astrophysics Data System (ADS)

    Capri, M. A. L.; Dudal, D.; Pereira, A. D.; Fiorentini, D.; Guimaraes, M. S.; Mintz, B. W.; Palhares, L. F.; Sorella, S. P.

    2017-02-01

    In order to construct a gauge-invariant two-point function in a Yang-Mills theory, we propose the use of the all-order gauge-invariant transverse configurations Ah . Such configurations can be obtained through the minimization of the functional Amin2 along the gauge orbit within the BRST-invariant formulation of the Gribov-Zwanziger framework recently put forward in [1,2] for the class of the linear covariant gauges. This correlator turns out to provide a characterization of nonperturbative aspects of the theory in a BRST-invariant and gauge-parameter-independent way. In particular, it turns out that the poles of ⟨Aμh(k )Aνh(-k )⟩ are the same as those of the transverse part of the gluon propagator, which are also formally shown to be independent of the gauge parameter α entering the gauge condition through the Nielsen identities. The latter follow from the new exact BRST-invariant formulation introduced before. Moreover, the correlator ⟨Aμh(k )Aνh(-k )⟩ enables us to attach a BRST-invariant meaning to the possible positivity violation of the corresponding temporal Schwinger correlator, giving thus for the first time a consistent, gauge parameter independent, setup to adopt the positivity violation of ⟨Aμh(k )Aνh(-k )⟩ as a signature for gluon confinement. Finally, in the context of gauge theories supplemented with a fundamental Higgs field, we use ⟨Aμh(k )Aνh(-k )⟩ to probe the pole structure of the massive gauge boson in a gauge-invariant fashion.

  7. Non-Local Euclidean Medians.

    PubMed

    Chaudhury, Kunal N; Singer, Amit

    2012-11-01

    In this letter, we note that the denoising performance of Non-Local Means (NLM) can be improved at large noise levels by replacing the mean by the Euclidean median. We call this new denoising algorithm the Non-Local Euclidean Medians (NLEM). At the heart of NLEM is the observation that the median is more robust to outliers than the mean. In particular, we provide a simple geometric insight that explains why NLEM performs better than NLM in the vicinity of edges, particularly at large noise levels. NLEM can be efficiently implemented using iteratively reweighted least squares, and its computational complexity is comparable to that of NLM. We provide some preliminary results to study the proposed algorithm and to compare it with NLM.

  8. Regional White Matter Volumes Correlate with Delay Discounting

    PubMed Central

    Yu, Rongjun

    2012-01-01

    A preference for immediate gratification is a central feature in addictive processes. However, the neural structures underlying reward delay tolerance are still unclear. Healthy participants (n = 121) completed a delay discounting questionnaire assessing the extent to which they prefer smaller immediate rewards to larger delayed reward after undergoing magnetic resonance imaging (MRI) scanning. Whole brain voxel-based morphometric analysis shows that delay discounting severity was negatively correlated with right prefrontal subgyral white matter volume and positively correlated with white matter volume in parahippocampus/hippocampus, after whole brain correction. This study might better our understanding of the neural basis of impulsivity and addiction. PMID:22393420

  9. Conformal Janus on Euclidean sphere

    NASA Astrophysics Data System (ADS)

    Bak, Dongsu; Gustavsson, Andreas; Rey, Soo-Jong

    2016-12-01

    We interpret Janus as an interface in a conformal field theory and study its properties. The Janus is created by an exactly marginal operator and we study its effect on the interface conformal field theory on the Janus. We do this by utilizing the AdS/CFT correspondence. We compute the interface free energy both from leading correction to the Euclidean action in the dual gravity description and from conformal perturbation theory in the conformal field theory. We find that the two results agree each other and that the interface free energy scales precisely as expected from the conformal invariance of the Janus interface.

  10. Phylogenetic trees and Euclidean embeddings.

    PubMed

    Layer, Mark; Rhodes, John A

    2017-01-01

    It was recently observed by de Vienne et al. (Syst Biol 60(6):826-832, 2011) that a simple square root transformation of distances between taxa on a phylogenetic tree allowed for an embedding of the taxa into Euclidean space. While the justification for this was based on a diffusion model of continuous character evolution along the tree, here we give a direct and elementary explanation for it that provides substantial additional insight. We use this embedding to reinterpret the differences between the NJ and BIONJ tree building algorithms, providing one illustration of how this embedding reflects tree structures in data.

  11. Correlation between IVC dimensions and volume status on CT scan.

    PubMed

    Miraflor, Emily; Yeung, Louise; Strumwasser, Aaron; Sadjadi, Javid; Victorino, Gregory P

    2011-10-01

    End points of resuscitation in trauma patients are difficult to define. The size of the inferior vena cava (IVC) on CT scan may accurately indicate volume status and guide resuscitation efforts. Our hypothesis was that IVC "flatness" on CT scan reflects volume status in hemodynamically normal trauma patients. The study population was drawn from a database of trauma patients who had abdominal CT scans and lactate levels drawn on arrival. Lactate was chosen as a marker of volume status since hypotensive patients were unlikely to undergo CT. Anteroposterior (AP) and transverse (TV) diameters of the IVC were measured at the suprarenal and infrarenal locations. A flatness index was calculated for each location (TV ÷ AP) and this value was correlated with heart rate, blood pressure, and lactate. There was no difference in IVC flatness at the suprarenal or infrarenal position for patients with an elevated lactate compared with those with a normal lactate: 1.54 ± 0.18 versus 1.43 ± 0.08 (P = 0.2) suprarenal and 1.54 ± 0.46 versus 1.68 ± 0.58 (P = 0.4) infrarenal. IVC flatness at the suprarenal location weakly correlated with blood pressure (r = -0.29). IVC flatness did not correlate with blood pressure at the infrarenal location (r = -0.1). IVC flatness did not correlate with heart rate (P > 0.3) or age (P > 0.2). These results did not demonstrate a correlation between IVC flatness and the markers of intravascular volume of heart rate, blood pressure, or lactate. IVC flatness on CT scan is not a valid indicator of volume status in hemodynamically normal trauma patients. Copyright © 2011 Elsevier Inc. All rights reserved.

  12. Read-only high accuracy volume holographic optical correlator

    NASA Astrophysics Data System (ADS)

    Zhao, Tian; Li, Jingming; Cao, Liangcai; He, Qingsheng; Jin, Guofan

    2011-10-01

    A read-only volume holographic correlator (VHC) is proposed. After the recording of all of the correlation database pages by angular multiplexing, a stand-alone read-only high accuracy VHC will be separated from the VHC recording facilities which include the high-power laser and the angular multiplexing system. The stand-alone VHC has its own low power readout laser and very compact and simple structure. Since there are two lasers that are employed for recording and readout, respectively, the optical alignment tolerance of the laser illumination on the SLM is very sensitive. The twodimensional angular tolerance is analyzed based on the theoretical model of the volume holographic correlator. The experimental demonstration of the proposed read-only VHC is introduced and discussed.

  13. Weak correlation of starch and volume in synchronized photosynthetic cells

    NASA Astrophysics Data System (ADS)

    Rading, M. Michael; Sandmann, Michael; Steup, Martin; Chiarugi, Davide; Valleriani, Angelo

    2015-01-01

    In cultures of unicellular algae, features of single cells, such as cellular volume and starch content, are thought to be the result of carefully balanced growth and division processes. Single-cell analyses of synchronized photoautotrophic cultures of the unicellular alga Chlamydomonas reinhardtii reveal, however, that the cellular volume and starch content are only weakly correlated. Likewise, other cell parameters, e.g., the chlorophyll content per cell, are only weakly correlated with cell size. We derive the cell size distributions at the beginning of each synchronization cycle considering growth, timing of cell division and daughter cell release, and the uneven division of cell volume. Furthermore, we investigate the link between cell volume growth and starch accumulation. This work presents evidence that, under the experimental conditions of light-dark synchronized cultures, the weak correlation between both cell features is a result of a cumulative process rather than due to asymmetric partition of biomolecules during cell division. This cumulative process necessarily limits cellular similarities within a synchronized cell population.

  14. Cross-correlations between volume change and price change.

    PubMed

    Podobnik, Boris; Horvatic, Davor; Petersen, Alexander M; Stanley, H Eugene

    2009-12-29

    In finance, one usually deals not with prices but with growth rates R, defined as the difference in logarithm between two consecutive prices. Here we consider not the trading volume, but rather the volume growth rate R, the difference in logarithm between two consecutive values of trading volume. To this end, we use several methods to analyze the properties of volume changes |R|, and their relationship to price changes |R|. We analyze 14,981 daily recordings of the Standard and Poor's (S & P) 500 Index over the 59-year period 1950-2009, and find power-law cross-correlations between |R| and |R| by using detrended cross-correlation analysis (DCCA). We introduce a joint stochastic process that models these cross-correlations. Motivated by the relationship between |R| and |R|, we estimate the tail exponent alpha of the probability density function P(|R|) approximately |R|(-1-alpha) for both the S & P 500 Index as well as the collection of 1819 constituents of the New York Stock Exchange Composite Index on 17 July 2009. As a new method to estimate alpha, we calculate the time intervals tau(q) between events where R > q. We demonstrate that tau(q), the average of tau(q), obeys tau(q) approximately q(alpha). We find alpha approximately 3. Furthermore, by aggregating all tau(q) values of 28 global financial indices, we also observe an approximate inverse cubic law.

  15. Does Variability in Cognitive Performance Correlate with Frontal Brain Volume?

    PubMed Central

    Lövdén, Martin; Schmiedek, Florian; Kennedy, Kristen M.; Rodrigue, Karen M.; Lindenberger, Ulman; Raz, Naftali

    2012-01-01

    Little is known about the neural correlates of within-person variability in cognitive performance. We investigated associations between regional brain volumes and trial-to-trial, block-to-block, and day-to-day variability in choice-reaction time, and episodic and working memory accuracy. Healthy younger (n = 25) and older (n = 18) adults underwent 101 daily assessments of cognitive performance, and their regional brain volumes were measured manually on magnetic resonance images. Results showed that smaller prefrontal white matter volumes were associated with higher block-to-block variability in choice-reaction time performance, with a stronger association observed among older adults. Smaller volumes of the dorsolateral prefrontal cortex covaried with higher block-to-block variability in episodic memory (number-word pair) performance. This association was stronger for younger adults. The observed associations between variability and brain volume were not due to individual differences in mean performance. Trial-to-trial and day-to-day variability in cognitive performance were unrelated to regional brain volume. We thus report novel findings demonstrating that block-by-block variability in cognitive performance is associated with integrity of the prefrontal regions and that between-person differences in different measures of variability of cognitive performance reflect different age-related constellations of behavioral and neural antecedents. PMID:23000256

  16. Correlating the properties of amorphous silicon with its flexibility volume

    NASA Astrophysics Data System (ADS)

    Fan, Zhao; Ding, Jun; Li, Qing-Jie; Ma, Evan

    2017-04-01

    For metallic glasses, "flexibility volume" has recently been introduced as a property-revealing indicator of the structural state the glass is in. This parameter incorporates the atomic volume and the vibrational mean-square displacement, to combine both static structure and dynamics information. Flexibility volume was shown to quantitatively correlate with the properties of metallic glasses [J. Ding et al., Nat. Commun. 7, 13733 (2016), 10.1038/ncomms13733]. However, it remains to be examined if this parameter is useful for other types of glasses with bonding characteristics, atomic packing structures, as well as properties that are distinctly different from metallic glasses. In this paper, we tackle this issue through systematic molecular-dynamics simulations of amorphous silicon (a -Si) models produced with different cooling rates, as a -Si is a prototypical covalently bonded network glass whose structure and properties cannot be characterized using structural parameters such as free volume used for metallic and polymeric glasses. Specifically, we demonstrate a quantitative prediction of the shear modulus of a -Si from the flexibility for atomic motion. This flexibility volume descriptor, when evaluated on the atomic scale, is shown to also correlate well with local packing, as well as with the propensity for thermal relaxations and shear transformations, providing a metric to map out and explain the structural and mechanical heterogeneity in the amorphous material. This case study of a model of covalently bonded network a -Si, together with our earlier demonstration for metallic glasses, points to the universality of flexibility volume as an indicator of the structure state to link with properties, applicable across amorphous materials with different chemical bonding and atomic packing structures.

  17. Printing Non-Euclidean Solids

    NASA Astrophysics Data System (ADS)

    Zurlo, Giuseppe; Truskinovsky, Lev

    2017-07-01

    Geometrically frustrated solids with a non-Euclidean reference metric are ubiquitous in biology and are becoming increasingly relevant in technological applications. Often they acquire a targeted configuration of incompatibility through the surface accretion of mass as in tree growth or dam construction. We use the mechanics of incompatible surface growth to show that geometrical frustration developing during deposition can be fine-tuned to ensure a particular behavior of the system in physiological (or working) conditions. As an illustration, we obtain an explicit 3D printing protocol for arteries, which guarantees stress uniformity under inhomogeneous loading, and for explosive plants, allowing a complete release of residual elastic energy with a single cut. Interestingly, in both cases reaching the physiological target requires the incompatibility to have a topological (global) component.

  18. Putamen volume correlates with obsessive compulsive characteristics in healthy population.

    PubMed

    Kubota, Yasutaka; Sato, Wataru; Kochiyama, Takanori; Uono, Shota; Yoshimura, Sayaka; Sawada, Reiko; Sakihama, Morimitsu; Toichi, Motomi

    2016-03-30

    Obsessions and compulsions (OCs) are frequent in healthy subjects; however neural backgrounds of the subclinical OCs were largely unknown. Results from recent studies suggested involvement of the putamen in the OC traits. To investigate this issue, 49 healthy subjects were assessed using structural magnetic resonance imaging (MRI) and the Maudsley Obsessive Compulsive Inventory (MOCI). Anatomical delineation on MRI yielded the global volume and local shape of the putamen. Other striatal structures (the caudate nucleus and globus pallidus) were also examined for exploratory purpose. The relationship between volume/shape of each structures and MOCI measure was analyzed, with sex, age, state anxiety, trait anxiety, and full-scale Intelligence Quotient regressed out. The volume analysis revealed a positive relationship between the MOCI total score and the bilateral putamen volumes. The shape analysis demonstrated associations between the higher MOCI total score and hypertrophy of the anterior putamen in both hemispheres. The present study firstly revealed that the volume changes of the putamen correlated with the manifestation of subclinical OC traits. The dysfunctional cortico-anterior striatum networks seemed to be one of the neuronal subsystems underlying the subclinical OC traits.

  19. Cross-correlations between volume change and price change

    PubMed Central

    Podobnik, Boris; Horvatic, Davor; Petersen, Alexander M.; Stanley, H. Eugene

    2009-01-01

    In finance, one usually deals not with prices but with growth rates R, defined as the difference in logarithm between two consecutive prices. Here we consider not the trading volume, but rather the volume growth rate R̃, the difference in logarithm between two consecutive values of trading volume. To this end, we use several methods to analyze the properties of volume changes |R̃|, and their relationship to price changes |R|. We analyze 14,981 daily recordings of the Standard and Poor's (S & P) 500 Index over the 59-year period 1950–2009, and find power-law cross-correlations between |R| and |R̃| by using detrended cross-correlation analysis (DCCA). We introduce a joint stochastic process that models these cross-correlations. Motivated by the relationship between |R| and |R̃|, we estimate the tail exponent α̃ of the probability density function P(|R̃|) ∼ |R̃|−1−α̃ for both the S & P 500 Index as well as the collection of 1819 constituents of the New York Stock Exchange Composite Index on 17 July 2009. As a new method to estimate α̃, we calculate the time intervals τq between events where R̃ > q. We demonstrate that τ̃q, the average of τq, obeys τ̃q ∼ qα̃. We find α̃ ≈ 3. Furthermore, by aggregating all τq values of 28 global financial indices, we also observe an approximate inverse cubic law. PMID:20018772

  20. Recording of incoherent reflective volume Fourier holograms for optical correlators

    NASA Astrophysics Data System (ADS)

    Rodin, Vladislav G.; Starikov, Sergey N.

    2007-01-01

    The scheme of recording of reflective volume Fourier holograms in monochromatic light with partial spatial coherence is presented. The scheme contains posed on one optical axis an illuminated or self-luminous object, Fourier-objective, photosensitive medium and concave mirror. The light is proposed to be monochromatic with partial spatial coherence. The object is located in a front focal plane of the Fourier-objective. Photosensitive medium is placed in a back focal plane of the Fourier-objective, and the mirror is posed on a double focal length of the mirror from photosensitive medium. The light from input object is focused by the Fourier-objective in a volume of photosensitive medium, shaping a far field diffraction pattern of input object. This pattern is partial coherent analog of Fourier transform of input object. The light transmitted through the medium falls on the concave mirror and is reflected back, thus the mirror shapes the second copy of far field diffraction pattern of input object in the volume of photosensitive medium. Thus, these two light waves, propagating in the opposite directions, form the interference pattern in photosensitive medium, and a reflective volume Fourier hologram is recorded by monochromatic light with partial spatial coherence. The experiments on recording of these holograms and image reconstruction were realized. Patent by Russian Federation No2176099 on the device of recording of reflective volume holographic Fourier-filter in light with partial spatial coherence was taken out. Described reflective volume Fourier-holograms can be used in optical correlators as the spatial filters and spectral selectors at image recognition both in monochromatic and polychromatic light.

  1. Euclidean supersymmetry, twisting and topological sigma models

    NASA Astrophysics Data System (ADS)

    Hull, C. M.; Lindström, U.; Melo dos Santos, L.; von Unge, R.; Zabzine, M.

    2008-06-01

    We discuss two dimensional N-extended supersymmetry in Euclidean signature and its R-symmetry. For N = 2, the R-symmetry is SO(2) × SO(1, 1), so that only an A-twist is possible. To formulate a B-twist, or to construct Euclidean N = 2 models with H-flux so that the target geometry is generalised Kahler, it is necessary to work with a complexification of the sigma models. These issues are related to the obstructions to the existence of non-trivial twisted chiral superfields in Euclidean superspace.

  2. Non-Euclidean Geometry and Unreal Numbers.

    ERIC Educational Resources Information Center

    Thwaites, G. N.

    1989-01-01

    This article discusses two of the reasons for the decline of formal Euclidean geometry in recent syllabi: (1) Traditional approach; and (2) Inherent difficulties. Suggested are some reasons and examples as to why the decline should be reversed. (YP)

  3. Zero energy scattering calculation in Euclidean space

    NASA Astrophysics Data System (ADS)

    Carbonell, J.; Karmanov, V. A.

    2016-03-01

    We show that the Bethe-Salpeter equation for the scattering amplitude in the limit of zero incident energy can be transformed into a purely Euclidean form, as it is the case for the bound states. The decoupling between Euclidean and Minkowski amplitudes is only possible for zero energy scattering observables and allows determining the scattering length from the Euclidean Bethe-Salpeter amplitude. Such a possibility strongly simplifies the numerical solution of the Bethe-Salpeter equation and suggests an alternative way to compute the scattering length in Lattice Euclidean calculations without using the Luscher formalism. The derivations contained in this work were performed for scalar particles and one-boson exchange kernel. They can be generalized to the fermion case and more involved interactions.

  4. The origins of Schwinger's Euclidean Green's functions

    NASA Astrophysics Data System (ADS)

    Miller, Michael E.

    2015-05-01

    This paper places Julian Schwinger's development of the Euclidean Green's function formalism for quantum field theory in historical context. It traces the techniques employed in the formalism back to Schwinger's work on waveguides during World War II, and his subsequent formulation of the Minkowski space Green's function formalism for quantum field theory in 1951. Particular attention is dedicated to understanding Schwinger's physical motivation for pursuing the Euclidean extension of this formalism in 1958.

  5. Invariant performance of a volume holographic wavelet correlation processor

    NASA Astrophysics Data System (ADS)

    Feng, Wenyi; Yan, Yingbai; Jin, Guofan; Wu, Minxian; He, Qingsheng

    2000-04-01

    A multichannel optical correlation processor based on volume holographic associative memory in a photorefractive crystal and wavelet transform is proposed for human face recognition. Distortions due to shift, rotation, scale, and partial hiding are studied to understand invariant performance of the processor. Our results show that shift-invariance and rotation-invariance are key problems for practical applications of the processor to human face recognition. Theoretical analysis and simulation conclude that the focal length of the Fourier transform lens is the main factor to affect shift-invariance of the processor. Shift-invariance would be improved if the focal length were enlarged. With regard to rotation-invariance, a novel mechanism to recognize human faces with any rotation angle is proposed and testified by experiments. The processor is more practical with the improvement of invariance.

  6. An extension of digital volume correlation for multimodality image registration

    NASA Astrophysics Data System (ADS)

    Tudisco, E.; Jailin, C.; Mendoza, A.; Tengattini, A.; Andò, E.; Hall, Stephen A.; Viggiani, Gioacchino; Hild, F.; Roux, S.

    2017-09-01

    The question of registering two images (or image volumes) acquired with different modalities, and thus exhibiting different contrast, at different positions is addressed based on an extension of global digital image (or volume) correlation. A specific comparison metric is introduced allowing the signature of the different phases to be related. A first solution consists of a Gaussian mixture to describe the joint distribution of gray levels, which not only provides a matching of both images, but also offers a natural segmentation indicator. A second ‘self-adapting’ solution does not include any postulated a priori model for the joint histogram and leads to a registration of the images based on their initial histograms. The algorithm is implemented with a pyramidal multiscale framework for the sake of robustness. The proposed multiscale technique is tested on two 3D images obtained from x-ray and neutron tomography respectively. The proposed approach brings the two images to coincidence with a sub-pixel accuracy and allows for a ‘natural’ segmentation of the different phases.

  7. Simplicial Euclidean and Lorentzian Quantum Gravity

    NASA Astrophysics Data System (ADS)

    Ambjørn, J.

    2002-09-01

    One can try to define the theory of quantum gravity as the sum over geometries. In two dimensions the sum over Euclidean geometries can be performed constructively by the method of dynamical triangulations. One can define a proper-time propagator. This propagator can be used to calculate generalized Hartle-Hawking amplitudes and it can be used to understand the the fractal structure of quantum geometry. In higher dimensions the philosophy of defining the quantum theory, starting from a sum over Euclidean geometries, regularized by a reparametrization invariant cut off which is taken to zero, seems not to lead to an interesting continuum theory. The reason for this is the dominance of singular Euclidean geometries. Lorentzian geometries with a global causal structure are less singular. Using the framework of dynamical triangulations it is possible to give a constructive definition of the sum over such geometries, In two dimensions the theory can be solved analytically. It differs from two-dimensional Euclidean quantum gravity, and the relation between the two theories can be understood. In three dimensions the theory avoids the pathologies of three-dimensional Euclidean quantum gravity. General properties of the four-dimensional discretized theory have been established, but a detailed study of the continuum limit in the spirit of the renormalization group and asymptotic safety is till awaiting.

  8. Power law cross-correlations between price change and volume change of Indian stocks

    NASA Astrophysics Data System (ADS)

    Hasan, Rashid; Mohammed Salim, M.

    2017-05-01

    We study multifractal long-range correlations and cross-correlations of daily price change and volume change of 50 stocks that comprise Nifty index of National Stock Exchange, Mumbai, using MF-DFA and MF-DCCA methods. We find that the time series of price change are uncorrelated, whereas anti-persistent long-range multifractal correlations are found in volume change series. We also find antipersistent long-range multifractal cross-correlations between the time series of price change and volume change. As multifractality is a signature of complexity, we estimate complexity parameters of the time series of price change, volume change, and cross-correlated price-volume change by fitting the fourth-degree polynomials to their multifractal spectra. Our results indicate that the time series of price change display high complexity, whereas the time series of volume change and cross-correlated price-volume change display low complexity.

  9. Fuzzy Euclidean wormholes in de Sitter space

    NASA Astrophysics Data System (ADS)

    Chen, Pisin; Hu, Yao-Chieh; Yeom, Dong-han

    2017-07-01

    We investigate Euclidean wormholes in Einstein gravity with a massless scalar field in de Sitter space. Euclidean wormholes are possible due to the analytic continuation of the time as well as complexification of fields, where we need to impose the classicality after the Wick-rotation to the Lorentzian signatures. For some parameters, wormholes are preferred than Hawking-Moss instantons, and hence wormholes can be more fundamental than Hawking-Moss type instantons. Euclidean wormholes can be interpreted in three ways: (1) classical big bounce, (2) either tunneling from a small to a large universe or a creation of a collapsing and an expanding universe from nothing, and (3) either a transition from a contracting to a bouncing phase or a creation of two expanding universes from nothing. These various interpretations shed some light on challenges of singularities. In addition, these will help to understand tensions between various kinds of quantum gravity theories.

  10. Making Euclidean Geometry Compulsory: Are We Prepared?

    ERIC Educational Resources Information Center

    Van Putten, Sonja; Howie, Sarah; Stols, Gerrit

    2010-01-01

    This study investigated the attitude towards, as well as the level of understanding of Euclidean geometry in pre-service mathematics education (PME) students. In order to do so, a case study was undertaken within which a one group pre-post-test procedure was conducted around a geometry module, and a representative group of students was interviewed…

  11. Making Euclidean Geometry Compulsory: Are We Prepared?

    ERIC Educational Resources Information Center

    Van Putten, Sonja; Howie, Sarah; Stols, Gerrit

    2010-01-01

    This study investigated the attitude towards, as well as the level of understanding of Euclidean geometry in pre-service mathematics education (PME) students. In order to do so, a case study was undertaken within which a one group pre-post-test procedure was conducted around a geometry module, and a representative group of students was interviewed…

  12. MEDOF - MINIMUM EUCLIDEAN DISTANCE OPTIMAL FILTER

    NASA Technical Reports Server (NTRS)

    Barton, R. S.

    1994-01-01

    The Minimum Euclidean Distance Optimal Filter program, MEDOF, generates filters for use in optical correlators. The algorithm implemented in MEDOF follows theory put forth by Richard D. Juday of NASA/JSC. This program analytically optimizes filters on arbitrary spatial light modulators such as coupled, binary, full complex, and fractional 2pi phase. MEDOF optimizes these modulators on a number of metrics including: correlation peak intensity at the origin for the centered appearance of the reference image in the input plane, signal to noise ratio including the correlation detector noise as well as the colored additive input noise, peak to correlation energy defined as the fraction of the signal energy passed by the filter that shows up in the correlation spot, and the peak to total energy which is a generalization of PCE that adds the passed colored input noise to the input image's passed energy. The user of MEDOF supplies the functions that describe the following quantities: 1) the reference signal, 2) the realizable complex encodings of both the input and filter SLM, 3) the noise model, possibly colored, as it adds at the reference image and at the correlation detection plane, and 4) the metric to analyze, here taken to be one of the analytical ones like SNR (signal to noise ratio) or PCE (peak to correlation energy) rather than peak to secondary ratio. MEDOF calculates filters for arbitrary modulators and a wide range of metrics as described above. MEDOF examines the statistics of the encoded input image's noise (if SNR or PCE is selected) and the filter SLM's (Spatial Light Modulator) available values. These statistics are used as the basis of a range for searching for the magnitude and phase of k, a pragmatically based complex constant for computing the filter transmittance from the electric field. The filter is produced for the mesh points in those ranges and the value of the metric that results from these points is computed. When the search is concluded, the

  13. MEDOF - MINIMUM EUCLIDEAN DISTANCE OPTIMAL FILTER

    NASA Technical Reports Server (NTRS)

    Barton, R. S.

    1994-01-01

    The Minimum Euclidean Distance Optimal Filter program, MEDOF, generates filters for use in optical correlators. The algorithm implemented in MEDOF follows theory put forth by Richard D. Juday of NASA/JSC. This program analytically optimizes filters on arbitrary spatial light modulators such as coupled, binary, full complex, and fractional 2pi phase. MEDOF optimizes these modulators on a number of metrics including: correlation peak intensity at the origin for the centered appearance of the reference image in the input plane, signal to noise ratio including the correlation detector noise as well as the colored additive input noise, peak to correlation energy defined as the fraction of the signal energy passed by the filter that shows up in the correlation spot, and the peak to total energy which is a generalization of PCE that adds the passed colored input noise to the input image's passed energy. The user of MEDOF supplies the functions that describe the following quantities: 1) the reference signal, 2) the realizable complex encodings of both the input and filter SLM, 3) the noise model, possibly colored, as it adds at the reference image and at the correlation detection plane, and 4) the metric to analyze, here taken to be one of the analytical ones like SNR (signal to noise ratio) or PCE (peak to correlation energy) rather than peak to secondary ratio. MEDOF calculates filters for arbitrary modulators and a wide range of metrics as described above. MEDOF examines the statistics of the encoded input image's noise (if SNR or PCE is selected) and the filter SLM's (Spatial Light Modulator) available values. These statistics are used as the basis of a range for searching for the magnitude and phase of k, a pragmatically based complex constant for computing the filter transmittance from the electric field. The filter is produced for the mesh points in those ranges and the value of the metric that results from these points is computed. When the search is concluded, the

  14. Specific volume-hole volume correlations in amorphous carbohydrates: effect of temperature, molecular weight, and water content.

    PubMed

    Townrow, Sam; Roussenova, Mina; Giardiello, Maria-Isabelle; Alam, Ashraf; Ubbink, Job

    2010-02-04

    The specific volume and the nanostructure of the free volume of amorphous blends of maltose with a narrow molecular weight distribution maltopolymer were systematically studied as a function of temperature, water content, pressure, and blend composition. Correlations between the hole free volume and the specific volume were investigated in the glassy and rubbery phases and in solution using positron annihilation lifetime spectroscopy (PALS) and pressure-volume-temperature (PVT) measurements, with the aim to provide a consolidated mechanistic understanding of the relation between changes in molecular packing and at the molecular level and the behavior of the specific volume at the macrolevel. Both specific volume and hole volume show a linear dependence on the temperature, but with a slope which is higher in the rubbery state than in the glassy state. As a function of temperature, the hole volume and the specific volume are linearly related, with no discontinuity at the glass transition temperature (T(g)). In the glassy state, both the specific volume and the hole volume decrease nonlinearly with the addition of maltose to the maltopolymer matrix, due to a more efficient molecular packing. For variations in carbohydrate composition, a linear dependence between the hole volume and the specific volume was again observed. The role of water was found to be significantly more complex, with increasing water content causing an increase in density in both the glassy and rubbery phases indicating that water exists in a highly dispersed state with a significantly lower specific molar volume than in bulk water. At very low water contents, the hole volume and the specific volume both decrease with increasing water content, which suggests that water acts as both a hole filler and a plasticizer. In the glassy state at slightly higher water contents, the specific volume continues to slowly decrease, but the hole size passes through a minimum before it starts to increase. This

  15. Linking covariant and canonical loop quantum gravity: New solutions to the Euclidean scalar constraint

    NASA Astrophysics Data System (ADS)

    Alesci, Emanuele; Thiemann, Thomas; Zipfel, Antonia

    2012-07-01

    It is often emphasized that spin-foam models could realize a projection on the physical Hilbert space of canonical loop quantum gravity. As a first test, we analyze the one-vertex expansion of a simple Euclidean spin foam. We find that for fixed Barbero-Immirzi parameter γ=1, the one-vertex amplitude in the Kaminski, Kisielowski, and Lewandowski prescription annihilates the Euclidean Hamiltonian constraint of loop quantum gravity [T. Thiemann, Classical Quantum Gravity 15, 839 (1998).]. Since, for γ=1, the Lorentzian part of the Hamiltonian constraint does not contribute, this gives rise to new solutions of the Euclidean theory. Furthermore, we find that the new states only depend on the diagonal matrix elements of the volume. This seems to be a generic property when applying the spin-foam projector.

  16. Sex differences in the correlation of emotional control and amygdala volumes in adolescents

    PubMed Central

    Blanton, Rebecca E.; Chaplin, Tara M.; Sinha, Rajita

    2013-01-01

    We examined male and female adolescents (8–18 years of age) that were scanned with structural brain MRI and looked for a correlation between volume of the right or the left amygdala and parent-reported ability of emotional control. A sex difference was found in the correlation between emotional control and the corrected volume of the left amygdala (that is the amygdala volume adjusted for total cranial volume). In girls, smaller left amygdala volumes were associated with better emotional control. In boys, larger left amygdala volumes were associated with better emotional control. These findings suggest that healthy girls and boys show a difference in the correlation between parental reports of emotional control and the left amygdala volume. PMID:20729768

  17. Wavelet transform to improve recognition accuracy of a volume holographic correlator

    NASA Astrophysics Data System (ADS)

    Feng, Wenyi; Yan, Yingbai; Jin, Guofan; Wu, Minxian; He, Qingsheng

    1999-07-01

    Volume holographic associative storage in a photorefractive crystal provides an inherent mechanism to develop a multichannel correlation system with high parallelism. Wavelet transform is introduced to improve recognition accuracy of the system. A novel volume holographic correlator is proposed and constructed. Its application in human face recognition is studied, and experimental results are given.

  18. Correlation among body height, intelligence, and brain gray matter volume in healthy children.

    PubMed

    Taki, Yasuyuki; Hashizume, Hiroshi; Sassa, Yuko; Takeuchi, Hikaru; Asano, Michiko; Asano, Kohei; Kotozaki, Yuka; Nouchi, Rui; Wu, Kai; Fukuda, Hiroshi; Kawashima, Ryuta

    2012-01-16

    A significant positive correlation between height and intelligence has been demonstrated in children. Additionally, intelligence has been associated with the volume of gray matter in the brains of children. Based on these correlations, we analyzed the correlation among height, full-scale intelligence quotient (IQ) and gray matter volume applying voxel-based morphometry using data from the brain magnetic resonance images of 160 healthy children aged 5-18 years of age. As a result, body height was significantly positively correlated with brain gray matter volume. Additionally, the regional gray matter volume of several regions such as the bilateral prefrontal cortices, temporoparietal region, and cerebellum was significantly positively correlated with body height and that the gray matter volume of several of these regions was also significantly positively correlated with full-scale intelligence quotient (IQ) scores after adjusting for age, sex, and socioeconomic status. Our results demonstrate that gray and white matter volume may mediate the correlation between body height and intelligence in healthy children. Additionally, the correlations among gray and white matter volume, height, and intelligence may be at least partially explained by the effect of insulin-like growth factor-1 and growth hormones. Given the importance of the effect of environmental factors, especially nutrition, on height, IQ, and gray matter volume, the present results stress the importance of nutrition during childhood for the healthy maturation of body and brain. Copyright © 2011 Elsevier Inc. All rights reserved.

  19. The Fourier Transform on Quantum Euclidean Space

    NASA Astrophysics Data System (ADS)

    Coulembier, Kevin

    2011-05-01

    We study Fourier theory on quantum Euclidean space. A modified version of the general definition of the Fourier transform on a quantum space is used and its inverse is constructed. The Fourier transforms can be defined by their Bochner's relations and a new type of q-Hankel transforms using the first and second q-Bessel functions. The behavior of the Fourier transforms with respect to partial derivatives and multiplication with variables is studied. The Fourier transform acts between the two representation spaces for the harmonic oscillator on quantum Euclidean space. By using this property it is possible to define a Fourier transform on the entire Hilbert space of the harmonic oscillator, which is its own inverse and satisfies the Parseval theorem.

  20. The Euclidean distribution of fast radio bursts

    NASA Astrophysics Data System (ADS)

    Oppermann, Niels; Connor, Liam D.; Pen, Ue-Li

    2016-09-01

    We investigate whether current data on the distribution of observed flux densities of fast radio bursts (FRBs) are consistent with a constant source density in Euclidean space. We use the number of FRBs detected in two surveys with different characteristics along with the observed signal-to-noise ratios of the detected FRBs in a formalism similar to a V/Vmax-test to constrain the distribution of flux densities. We find consistency between the data and a Euclidean distribution. Any extension of this model is therefore not data-driven and needs to be motivated separately. As a byproduct we also obtain new improved limits for the FRB rate at 1.4 GHz, which had not been constrained in this way before.

  1. Euclidean resonance in a magnetic field

    SciTech Connect

    Ivlev, B.

    2007-08-15

    An analogy is found between Wigner resonant tunneling and tunneling across a static potential barrier in a static magnetic field. Whereas in the process of Wigner tunneling an electron encounters a classically allowed region where a discrete energy level coincides with its energy, in the magnetic field the potential barrier is constant in the direction of tunneling. Along the tunneling path, certain regions are formed where, in the classical language, the kinetic energy of the motion perpendicular to tunneling is negative. These regions play the role of potential wells, where a discrete energy level can coincide with the electron energy. This phenomenon, which occurs at a certain magnetic field, is called Euclidean resonance and substantially depends on the shape of the potential forces in the direction perpendicular to tunneling. Under conditions of Euclidean resonance, a long-distance underbarrier motion is possible, which can be observed in experiments.

  2. On the sensitivity of a Euclidean projection

    NASA Astrophysics Data System (ADS)

    Izmailov, A. F.; Kurennoy, A. S.

    2014-03-01

    The structure and behavior of Euclidean projections of a point onto a set defined by parametric constraints is studied. Under the Mangasarian-Fromovitz constraint qualification, it is shown that the projection is locally unique and continuous and, if the feasible set is constant, locally Lipschitz continuous as well. Quantitative results are obtained characterizing the asymptotic behavior of projections under perturbations in a given direction.

  3. Fuzzy Euclidean wormholes in de Sitter space

    DOE PAGES

    Chen, Pisin; Hu, Yao-Chieh; Yeom, Dong-han

    2017-07-03

    Here, we investigate Euclidean wormholes in Einstein gravity with a massless scalar field in de Sitter space. Euclidean wormholes are possible due to the analytic continuation of the time as well as complexification of fields, where we need to impose the classicality after the Wick-rotation to the Lorentzian signatures. Furthermore, we prefer wormholes for some parameters, rather than Hawking-Moss instantons, and hence wormholes can be more fundamental than Hawking-Moss type instantons. Euclidean wormholes can be interpreted in three ways: (1) classical big bounce, (2) either tunneling from a small to a large universe or a creation of a collapsing andmore » an expanding universe from nothing, and (3) either a transition from a contracting to a bouncing phase or a creation of two expanding universes from nothing. These various interpretations shed some light on challenges of singularities. In addition, these will help to understand tensions between various kinds of quantum gravity theories.« less

  4. Geometric Deep Learning: Going beyond Euclidean data

    NASA Astrophysics Data System (ADS)

    Bronstein, Michael M.; Bruna, Joan; LeCun, Yann; Szlam, Arthur; Vandergheynst, Pierre

    2017-07-01

    Many scientific fields study data with an underlying structure that is a non-Euclidean space. Some examples include social networks in computational social sciences, sensor networks in communications, functional networks in brain imaging, regulatory networks in genetics, and meshed surfaces in computer graphics. In many applications, such geometric data are large and complex (in the case of social networks, on the scale of billions), and are natural targets for machine learning techniques. In particular, we would like to use deep neural networks, which have recently proven to be powerful tools for a broad range of problems from computer vision, natural language processing, and audio analysis. However, these tools have been most successful on data with an underlying Euclidean or grid-like structure, and in cases where the invariances of these structures are built into networks used to model them. Geometric deep learning is an umbrella term for emerging techniques attempting to generalize (structured) deep neural models to non-Euclidean domains such as graphs and manifolds. The purpose of this paper is to overview different examples of geometric deep learning problems and present available solutions, key difficulties, applications, and future research directions in this nascent field.

  5. Preterm Infant Hippocampal Volumes Correlate with Later Working Memory Deficits

    ERIC Educational Resources Information Center

    Beauchamp, Miriam H.; Thompson, Deanne K.; Howard, Kelly; Doyle, Lex W.; Egan, Gary F.; Inder, Terrie E.; Anderson, Peter J.

    2008-01-01

    Children born preterm exhibit working memory deficits. These deficits may be associated with structural brain changes observed in the neonatal period. In this study, the relationship between neonatal regional brain volumes and working memory deficits at age 2 years were investigated, with a particular interest in the dorsolateral prefrontal…

  6. Preterm Infant Hippocampal Volumes Correlate with Later Working Memory Deficits

    ERIC Educational Resources Information Center

    Beauchamp, Miriam H.; Thompson, Deanne K.; Howard, Kelly; Doyle, Lex W.; Egan, Gary F.; Inder, Terrie E.; Anderson, Peter J.

    2008-01-01

    Children born preterm exhibit working memory deficits. These deficits may be associated with structural brain changes observed in the neonatal period. In this study, the relationship between neonatal regional brain volumes and working memory deficits at age 2 years were investigated, with a particular interest in the dorsolateral prefrontal…

  7. Price-volume cross-correlation analysis of CSI300 index futures

    NASA Astrophysics Data System (ADS)

    Wang, Dong-Hua; Suo, Yuan-Yuan; Yu, Xiao-Wen; Lei, Man

    2013-03-01

    We investigate the cross-correlation between price returns and trading volumes for the China Securities Index 300 (CSI300) index futures, which are the only stock index futures traded on the China Financial Futures Exchange (CFFEX). The basic statistics suggest that distributions of these two time series are not normal but exhibit fat tails. Based on the detrended cross-correlation analysis (DCCA), we obtain that returns and trading volumes are long-range cross-correlated. The existence of multifractality in the cross-correlation between returns and trading volumes has been proven with the multifractal detrended cross-correlation analysis (MFDCCA) algorithm. The multifractal analysis also confirms that returns and trading volumes have different degrees of multifractality. We further perform a cross-correlation statistic to verify whether the cross-correlation significantly exists between returns and trading volumes for CSI300 index futures. In addition, results of the test for lead-lag effect demonstrate that contemporaneous cross-correlation of return and trading volume series is stronger than cross-correlations of leaded or lagged series.

  8. Correlation of clinical findings and brain volume data in multiple sclerosis.

    PubMed

    Fragoso, Yara Dadalti; Wille, Paulo Roberto; Abreu, Marcelo; Brooks, Joseph Bruno B; Dias, Ronaldo Maciel; Duarte, Juliana Avila; Farage, Luciano; Finkelsztejn, Alessandro; Frohlich, Alan Christmann; Goncalves, Marcus Vinicius Magno; Guedes, Bruno V Sobreira; Medeiros, Leonardo; Oliveira, Rodrigo Andre; Ribas, Flavio Diniz; da Rocha, Fernando Coronetti Gomes; Santos, Gutemberg Augusto C; Scorcine, Claudio; da Silveira, Guilherme Lopes; Spedo, Carina Tellaroli; Tauil, Carlos Bernardo; Varela, Juliana Santos; Vieira, Vera Lucia Ferreira

    2017-10-01

    Brain volume measurements are becoming an important tool for assessing success in controlling multiple sclerosis (MS) activity. MSmetrix (icometrix) is an easy-to-use platform, specific for MS magnetic resonance imaging (MRI) of the brain. It provides data on total brain volume, grey matter volume and lesion load volume. The objective of the present study was to assess whether disability and the number of relapses during the previous year correlated with brain volume measurements from MSmetrix. Data on 185 icometrix reports from patients with MS were used to evaluate the potential correlation between brain volume measurements and clinical parameters. There was a significant correlation between higher disability and decreased brain volume (total and grey matter). Increased lesion load in the brain and higher number of relapses in the previous year were also independently correlated with decreased brain tissue volume and with increased disability. This is the first study with real-world data to show that icometrix is a relevant tool for the study of brain volume loss in MS. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Long-term correlations and multifractality in trading volumes for Chinese stocks

    NASA Astrophysics Data System (ADS)

    Mu, Guo-Hua; Zhou, Wei-Xing; Chen, Wei; Kertész, János

    2010-08-01

    We investigate the temporal correlations and multifractal nature of trading volume of 22 liquid stocks traded on the Shenzhen Stock Exchange in 2003. We find that non-universal long memory exhibits size-dependence on the trading volume, while the multifractal nature is independent of the trading volume. No crossover in the power-law dependence of the detrended fluctuation functions is observed. Our results show that the intraday pattern in the trading volume has negligible impact on the long memory and multifractality. We also find that both the long memory and probability distribution of trading volume have important influence on the multifractal nature.

  10. Hand surgery volume and the US economy: is there a statistical correlation?

    PubMed

    Gordon, Chad R; Pryor, Landon; Afifi, Ahmed M; Gatherwright, James R; Evans, Peter J; Hendrickson, Mark; Bernard, Steven; Zins, James E

    2010-11-01

    To the best of our knowledge, there have been no previous studies evaluating the correlation of the US economy and hand surgery volume. Therefore, in light of the current recession, our objective was to study our institution's hand surgery volume over the last 17 years in relation to the nation's economy. A retrospective analysis of our institution's hand surgery volume, as represented by our most common procedure (ie, carpal tunnel release), was performed between January 1992 and October 2008. Liposuction and breast augmentation volumes were chosen to serve as cosmetic plastic surgery comparison groups. Pearson correlation statistics were used to estimate the relationship between the surgical volume and the US economy, as represented by the 3 market indices (Dow Jones, NASDAQ, and S&P500). A combined total of 7884 hand surgery carpal tunnel release (open or endoscopic) patients were identified. There were 1927 (24%) and 5957 (76%) patients within the departments of plastic and orthopedic surgery, respectively. In the plastic surgery department, there was a strong negative (ie, inverse relationship) correlation between hand surgery volume and the economy (P < 0.001). In converse, the orthopedic department's hand surgery volume demonstrated a positive (ie, parallel) correlation (P < 0.001). The volumes of liposuction and breast augmentation also showed a positive correlation (P < 0.001). To our knowledge, we have demonstrated for the first time an inverse (ie, negative) correlation between hand surgery volumes performed by plastic surgeons in relation to the US economy, as represented by the 3 major market indices. In contrast, orthopedic hand surgery volume and cosmetic surgery show a parallel (ie, positive) correlation. This data suggests that plastic surgeons are increasing their cosmetic surgery-to-reconstructive/hand surgery ratio during strong economic times and vice versa during times of economic slowdown.

  11. Volume Functions of Historical Texts and the Amplitude Correlation Principle.

    ERIC Educational Resources Information Center

    Fomenko, Anatoliy T.; Rachev, Svetlozar T.

    1990-01-01

    Proposes an empirico-statistical model to differentiate dependent and independent historical texts. Formulates a regard for information principle and an amplitude correlation principle. Experimentally examines and validates the model and both principles using specific historical texts. Includes tables and graphs. Appends further discussion of the…

  12. Correlation between hippocampal volumes and medial temporal lobe atrophy in patients with Alzheimer's disease

    PubMed Central

    Dhikav, Vikas; Duraiswamy, Sharmila; Anand, Kuljeet Singh

    2017-01-01

    Introduction: Hippocampus undergoes atrophy in patients with Alzheimer's disease (AD). Calculation of hippocampal volumes can be done by a variety of methods using T1-weighted images of magnetic resonance imaging (MRI) of the brain. Medial temporal lobes atrophy (MTL) can be rated visually using T1-weighted MRI brain images. The present study was done to see if any correlation existed between hippocampal volumes and visual rating scores of the MTL using Scheltens Visual Rating Method. Materials and Methods: We screened 84 subjects presented to the Department of Neurology of a Tertiary Care Hospital and enrolled forty subjects meeting the National Institute of Neurological and Communicative Disorders and Stroke, AD related Disease Association criteria. Selected patients underwent MRI brain and T1-weighted images in a plane perpendicular to long axis of hippocampus were obtained. Hippocampal volumes were calculated manually using a standard protocol. The calculated hippocampal volumes were correlated with Scheltens Visual Rating Method for Rating MTL. A total of 32 cognitively normal age-matched subjects were selected to see the same correlation in the healthy subjects as well. Sensitivity and specificity of both methods was calculated and compared. Results: There was an insignificant correlation between the hippocampal volumes and MTL rating scores in cognitively normal elderly (n = 32; Pearson Correlation coefficient = 0.16, P > 0.05). In the AD Group, there was a moderately strong correlation between measured hippocampal volumes and MTL Rating (Pearson's correlation coefficient = −0.54; P < 0.05. There was a moderately strong correlation between hippocampal volume and Mini-Mental Status Examination in the AD group. Manual delineation was superior compared to the visual method (P < 0.05). Conclusions: Good correlation was present between manual hippocampal volume measurements and MTL scores. Sensitivity and specificity of manual measurement of hippocampus was

  13. Correlation between hippocampal volumes and medial temporal lobe atrophy in patients with Alzheimer's disease.

    PubMed

    Dhikav, Vikas; Duraiswamy, Sharmila; Anand, Kuljeet Singh

    2017-01-01

    Hippocampus undergoes atrophy in patients with Alzheimer's disease (AD). Calculation of hippocampal volumes can be done by a variety of methods using T1-weighted images of magnetic resonance imaging (MRI) of the brain. Medial temporal lobes atrophy (MTL) can be rated visually using T1-weighted MRI brain images. The present study was done to see if any correlation existed between hippocampal volumes and visual rating scores of the MTL using Scheltens Visual Rating Method. We screened 84 subjects presented to the Department of Neurology of a Tertiary Care Hospital and enrolled forty subjects meeting the National Institute of Neurological and Communicative Disorders and Stroke, AD related Disease Association criteria. Selected patients underwent MRI brain and T1-weighted images in a plane perpendicular to long axis of hippocampus were obtained. Hippocampal volumes were calculated manually using a standard protocol. The calculated hippocampal volumes were correlated with Scheltens Visual Rating Method for Rating MTL. A total of 32 cognitively normal age-matched subjects were selected to see the same correlation in the healthy subjects as well. Sensitivity and specificity of both methods was calculated and compared. There was an insignificant correlation between the hippocampal volumes and MTL rating scores in cognitively normal elderly (n = 32; Pearson Correlation coefficient = 0.16, P > 0.05). In the AD Group, there was a moderately strong correlation between measured hippocampal volumes and MTL Rating (Pearson's correlation coefficient = -0.54; P < 0.05. There was a moderately strong correlation between hippocampal volume and Mini-Mental Status Examination in the AD group. Manual delineation was superior compared to the visual method (P < 0.05). Good correlation was present between manual hippocampal volume measurements and MTL scores. Sensitivity and specificity of manual measurement of hippocampus was higher compared to visual rating scores for MTL in patients with

  14. Correlation of cervicovaginal fluid volume with serum estradiol levels and total follicular volume during human gonadotropin stimulation.

    PubMed

    Pratt, D E; Vignovic, E; Holt, J A; Schumacher, G F

    1992-02-01

    During the normal menstrual cycle the volume of cervicovaginal fluid (CVF), as determined by the patient at home using a simple volumetric aspirating pipette, increases significantly over several days prior to the luteinizing hormone (LH) surge and decreases characteristically shortly after ovulation. The present study was undertaken to test the hypothesis that self-determined measurements of CVF volume would correlate positively with serum estradiol (E2) levels and with total follicular volume (TFV) in cycles stimulated with exogenous gonadotropins. Consequently, 20 infertility patients, undergoing human menopausal gonadotropin (hMG)-stimulated cycles, were asked to measure daily CVF. Routine serum E2 determinations and vaginal follicular ultrasound studies were performed up to and including the day of human chorionic gonadotropin (hCG) administration (designated day 0). The mean daily CVF volume (+/- SD) increased from 0.1 +/- 0.01 ml on day -6 to 0.7 +/- 0.40 ml on day -1 and then decreased to 0.6 +/- 0.40 ml on day 0. On day 0, 7 of 20 cycles (35%) demonstrated a decrease in CVF, which ranged from 0.1 to 1.0 ml (mean, 0.42 ml). The mean daily CVF correlated positively (correlation coefficient = r) with the mean daily serum E2 (r = 0.89) and with the mean daily TFV (r = 0.88). The mean daily correlation of TFV for E2 was r = 0.98. The correlation between CVF and E2 of individuals ranged from r = 0.38 to r = 0.99 and the correlation between CVF and TFV ranged from r = 0.12 to r = 1.0, while the individual correlations of E2 to TFV ranged from r = 0.60 to r = 0.99.(ABSTRACT TRUNCATED AT 250 WORDS)

  15. Harmonic and Monogenic Potentials in Euclidean Halfspace

    NASA Astrophysics Data System (ADS)

    Brackx, F.; De Bie, H.; De Schepper, H.

    2011-09-01

    In the framework of Clifford analysis a chain of harmonic and monogenic potentials is constructed in the upper half of Euclidean space Rm+1. Their distributional limits at the boundary are computed, obtaining in this way well-known distributions in Rm such as the Dirac distribution, the Hilbert kernel, the square root of the negative Laplace operator, and the like. It is shown how each of those potentials may be recovered from an adjacent kernel in the chain by an appropriate convolution with such a distributional limit.

  16. Broadband invisibility by non-Euclidean cloaking.

    PubMed

    Leonhardt, Ulf; Tyc, Tomás

    2009-01-02

    Invisibility and negative refraction are both applications of transformation optics where the material of a device performs a coordinate transformation for electromagnetic fields. The device creates the illusion that light propagates through empty flat space, whereas in physical space, light is bent around a hidden interior or seems to run backward in space or time. All of the previous proposals for invisibility require materials with extreme properties. Here we show that transformation optics of a curved, non-Euclidean space (such as the surface of a virtual sphere) relax these requirements and can lead to invisibility in a broad band of the spectrum.

  17. Complementary Characteristics of Correlation Patterns in Morphometric Correlation Networks of Cortical Thickness, Surface Area, and Gray Matter Volume.

    PubMed

    Yang, Jin-Ju; Kwon, Hunki; Lee, Jong-Min

    2016-05-26

    Morphometric correlation networks of cortical thickness, surface area, and gray matter volume have statistically different structural topology. However, there is no report directly describing their correlation patterns in view of interregional covariance. Here, we examined the characteristics of the correlation patterns in three morphometric networks of cortical thickness, surface area, and gray matter volume using a Venn diagram concept across 314 normal subjects. We found that over 60% of all nonoverlapping correlation patterns emerged with divergent unique patterns, while there were 10% of all common edges in ipsilateral and homotopic regions among the three morphometric correlation networks. It was also found that the network parameters of the three networks were different. Our findings showed that correlation patterns of the network itself can provide complementary information when compared with network properties. We demonstrate that morphometric correlation networks of distinct structural phenotypes have different correlation patterns and different network properties. This finding implies that the topology of each morphometric correlation network may reflect different aspects of each morphometric descriptor.

  18. Inter-Fraction Tumor Volume Response during Lung Stereotactic Body Radiation Therapy Correlated to Patient Variables.

    PubMed

    Salamekh, Samer; Rong, Yi; Ayan, Ahmet S; Mo, Xiaokui; Williams, Terence M; Mayr, Nina A; Grecula, John C; Chakravarti, Arnab; Xu-Welliver, Meng

    2016-01-01

    Analyze inter-fraction volumetric changes of lung tumors treated with stereotactic body radiation therapy (SBRT) and determine if the volume changes during treatment can be predicted and thus considered in treatment planning. Kilo-voltage cone-beam CT (kV-CBCT) images obtained immediately prior to each fraction were used to monitor inter-fraction volumetric changes of 15 consecutive patients (18 lung nodules) treated with lung SBRT at our institution (45-54 Gy in 3-5 fractions) in the year of 2011-2012. Spearman's (ρ) correlation and Spearman's partial correlation analysis was performed with respect to patient/tumor and treatment characteristics. Multiple hypothesis correction was performed using False Discovery Rate (FDR) and q-values were reported. All tumors studied experienced volume change during treatment. Tumor increased in volume by an average of 15% and regressed by an average of 11%. The overall volume increase during treatment is contained within the planning target volume (PTV) for all tumors. Larger tumors increased in volume more than smaller tumors during treatment (q = 0.0029). The volume increase on CBCT was correlated to the treatment planning gross target volume (GTV) as well as internal target volumes (ITV) (q = 0.0085 and q = 0.0039 respectively) and could be predicted for tumors with a GTV less than 22 mL. The volume increase was correlated to the integral dose (ID) in the ITV at every fraction (q = 0.0049). The peak inter-fraction volume occurred at an earlier fraction in younger patients (q = 0.0122). We introduced a new analysis method to follow inter-fraction tumor volume changes and determined that the observed changes during lung SBRT treatment are correlated to the initial tumor volume, integral dose (ID), and patient age. Furthermore, the volume increase during treatment of tumors less than 22mL can be predicted during treatment planning. The volume increase remained significantly less than the overall PTV expansion, and radiation re

  19. Cross-correlations between price and volume in Chinese gold markets

    NASA Astrophysics Data System (ADS)

    Ruan, Qingsong; Jiang, Wei; Ma, Guofeng

    2016-06-01

    We apply the multifractal detrended cross-correlation analysis (MF-DCCA) method to investigate the cross-correlation behaviors between price and volume in Chinese gold spot and futures markets. Qualitatively, we find that the price and volume series are significantly cross-correlated using the cross-correlation test statistics Qcc(m) and the ρDCCA coefficients. Quantitatively, by employing the MF-DCCA analysis, we find that there is a power-law cross-correlation and significant multifractal features between price and volume in gold spot and futures markets. Furthermore, by comparing the multifractality of the original series to the shuffled and surrogated series, we find that, for the gold spot market, the main contribution of multifractality is fat-tail distribution; for the gold futures market, both long-range correlations and fat-tail distributions play important roles in the contribution of multifractality. Finally, by employing the method of rolling windows, we undertake further investigation into the time-varying features of the cross-correlations between price and volume. We find that for both spot and futures markets, the cross-correlations are anti-persistent in general. In the short term, the cross-correlation shows obvious fluctuations due to exogenous shocks while, in the long term, the relationship tends to be at a metastable level due to the dynamic mechanism.

  20. Founding Gravitation in 4D Euclidean Space-Time Geometry

    SciTech Connect

    Winkler, Franz-Guenter

    2010-11-24

    The Euclidean interpretation of special relativity which has been suggested by the author is a formulation of special relativity in ordinary 4D Euclidean space-time geometry. The natural and geometrically intuitive generalization of this view involves variations of the speed of light (depending on location and direction) and a Euclidean principle of general covariance. In this article, a gravitation model by Jan Broekaert, which implements a view of relativity theory in the spirit of Lorentz and Poincare, is reconstructed and shown to fulfill the principles of the Euclidean approach after an appropriate reinterpretation.

  1. Role of the Euclidean signature in lattice calculations of quasidistributions and other nonlocal matrix elements

    NASA Astrophysics Data System (ADS)

    Briceño, Raúl A.; Hansen, Maxwell T.; Monahan, Christopher J.

    2017-07-01

    Lattice quantum chromodynamics (QCD) provides the only known systematic, nonperturbative method for first-principles calculations of nucleon structure. However, for quantities such as light-front parton distribution functions (PDFs) and generalized parton distributions (GPDs), the restriction to Euclidean time prevents direct calculation of the desired observable. Recently, progress has been made in relating these quantities to matrix elements of spatially nonlocal, zero-time operators, referred to as quasidistributions. Still, even for these time-independent matrix elements, potential subtleties have been identified in the role of the Euclidean signature. In this work, we investigate the analytic behavior of spatially nonlocal correlation functions and demonstrate that the matrix elements obtained from Euclidean lattice QCD are identical to those obtained using the Lehmann-Symanzik-Zimmermann reduction formula in Minkowski space. After arguing the equivalence on general grounds, we also show that it holds in a perturbative calculation, where special care is needed to identify the lattice prediction. Finally we present a proof of the uniqueness of the matrix elements obtained from Minkowski and Euclidean correlation functions to all order in perturbation theory.

  2. Role of the Euclidean signature in lattice calculations of quasidistributions and other nonlocal matrix elements

    DOE PAGES

    Briceno, Raul A.; Hansen, Maxwell T.; Monahan, Christopher J.

    2017-07-11

    Lattice quantum chromodynamics (QCD) provides the only known systematic, nonperturbative method for first-principles calculations of nucleon structure. However, for quantities such as light-front parton distribution functions (PDFs) and generalized parton distributions (GPDs), the restriction to Euclidean time prevents direct calculation of the desired observable. Recently, progress has been made in relating these quantities to matrix elements of spatially nonlocal, zero-time operators, referred to as quasidistributions. Still, even for these time-independent matrix elements, potential subtleties have been identified in the role of the Euclidean signature. In this work, we investigate the analytic behavior of spatially nonlocal correlation functions and demonstrate thatmore » the matrix elements obtained from Euclidean lattice QCD are identical to those obtained using the Lehmann-Symanzik-Zimmermann reduction formula in Minkowski space. After arguing the equivalence on general grounds, we also show that it holds in a perturbative calculation, where special care is needed to identify the lattice prediction. Lastly, we present a proof of the uniqueness of the matrix elements obtained from Minkowski and Euclidean correlation functions to all order in perturbation theory.« less

  3. Positron age-momentum correlation studies of free volumes in polymers

    NASA Astrophysics Data System (ADS)

    Sato, K.; Murakami, H.; Ito, K.; Hirata, K.; Kobayashi, Y.

    2009-12-01

    Positron age-momentum correlation (AMOC) spectroscopy, which can sensitively probe momentum distributions of positrons and positronium (Ps), was conducted for studying the pick-off process of the triplet bound state ortho-Ps ( o-Ps) with electrons at the walls of the free volumes in polymers. Influences of different chemical elements forming free volume were investigated. It was found that the momentum distribution of o-Ps pick-off annihilation sensitively depends on the electronic state in the free volumes. The feasibility of the chemical analysis relevant to the free volume in polymers is discussed.

  4. Physical Exercise Habits Correlate with Gray Matter Volume of the Hippocampus in Healthy Adult Humans

    NASA Astrophysics Data System (ADS)

    Killgore, William D. S.; Olson, Elizabeth A.; Weber, Mareen

    2013-12-01

    Physical activity facilitates neurogenesis of dentate cells in the rodent hippocampus, a brain region critical for memory formation and spatial representation. Recent findings in humans also suggest that aerobic exercise can lead to increased hippocampal volume and enhanced cognitive functioning in children and elderly adults. However, the association between physical activity and hippocampal volume during the period from early adulthood through middle age has not been effectively explored. Here, we correlated the number of minutes of self-reported exercise per week with gray matter volume of the hippocampus using voxel-based morphometry (VBM) in 61 healthy adults ranging from 18 to 45 years of age. After controlling for age, gender, and total brain volume, total minutes of weekly exercise correlated significantly with volume of the right hippocampus. Findings highlight the relationship between regular physical exercise and brain structure during early to middle adulthood.

  5. Physical exercise habits correlate with gray matter volume of the hippocampus in healthy adult humans.

    PubMed

    Killgore, William D S; Olson, Elizabeth A; Weber, Mareen

    2013-12-12

    Physical activity facilitates neurogenesis of dentate cells in the rodent hippocampus, a brain region critical for memory formation and spatial representation. Recent findings in humans also suggest that aerobic exercise can lead to increased hippocampal volume and enhanced cognitive functioning in children and elderly adults. However, the association between physical activity and hippocampal volume during the period from early adulthood through middle age has not been effectively explored. Here, we correlated the number of minutes of self-reported exercise per week with gray matter volume of the hippocampus using voxel-based morphometry (VBM) in 61 healthy adults ranging from 18 to 45 years of age. After controlling for age, gender, and total brain volume, total minutes of weekly exercise correlated significantly with volume of the right hippocampus. Findings highlight the relationship between regular physical exercise and brain structure during early to middle adulthood.

  6. Reduced anterior cingulate gyrus volume correlates with executive dysfunction in men with first-episode schizophrenia.

    PubMed

    Szeszko, P R; Bilder, R M; Lencz, T; Ashtari, M; Goldman, R S; Reiter, G; Wu, H; Lieberman, J A

    2000-06-16

    Although frontal lobe structural and functional abnormalities have been identified in schizophrenia, their relationship remains elusive. Because the frontal lobes are both structurally and functionally heterogeneous, it is possible that some measures of frontal lobe structure may not have accurately identified relevant frontal lobe subregions. The authors hypothesized that the volumes of two dorsal, 'archicortical' subregions (i.e. superior frontal gyrus and anterior cingulate gyrus), but not a ventral, 'paleocortical' subregion (i.e. orbital frontal region) would be significantly and selectively correlated with executive and motor dysfunction in patients with schizophrenia as previously reported for the anterior hippocampal region. Volumes of these frontal lobe subregions were measured from magnetic resonance images based on sulcal anatomy in 20 men and 15 women with first-episode schizophrenia. All patients completed a comprehensive neuropsychological test battery while clinically stabilized that encompassed six domains of functioning: attention, executive, motor, visuospatial, memory and language. Findings indicated that reduced anterior cingulate gyrus volume was significantly correlated with worse executive functioning in men; among women, there were no significant correlations. Among men, anterior cingulate gyrus volume was significantly more strongly correlated with executive functioning than with attention, visuospatial, memory, language and general intellectual functioning. Neither executive nor motor functioning was significantly more strongly correlated with the dorsal 'archicortical' volumes than with orbital frontal volume. These findings suggest a link between executive deficits and dysfunction of the dorsal 'archicortical' system and implicate sex differences in their relationship in first-episode schizophrenia.

  7. Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals.

    PubMed

    Taki, Yasuyuki; Thyreau, Benjamin; Kinomura, Shigeo; Sato, Kazunori; Goto, Ryoi; Kawashima, Ryuta; Fukuda, Hiroshi

    2011-01-01

    To determine the relationship between age and gray matter structure and how interactions between gender and hemisphere impact this relationship, we examined correlations between global or regional gray matter volume and age, including interactions of gender and hemisphere, using a general linear model with voxel-based and region-of-interest analyses. Brain magnetic resonance images were collected from 1460 healthy individuals aged 20-69 years; the images were linearly normalized and segmented and restored to native space for analysis of global gray matter volume. Linearly normalized images were then non-linearly normalized and smoothed for analysis of regional gray matter volume. Analysis of global gray matter volume revealed a significant negative correlation between gray matter ratio (gray matter volume divided by intracranial volume) and age in both genders, and a significant interaction effect of age × gender on the gray matter ratio. In analyzing regional gray matter volume, the gray matter volume of all regions showed significant main effects of age, and most regions, with the exception of several including the inferior parietal lobule, showed a significant age × gender interaction. Additionally, the inferior temporal gyrus showed a significant age × gender × hemisphere interaction. No regional volumes showed significant age × hemisphere interactions. Our study may contribute to clarifying the mechanism(s) of normal brain aging in each brain region.

  8. Correlations among Brain Gray Matter Volumes, Age, Gender, and Hemisphere in Healthy Individuals

    PubMed Central

    Taki, Yasuyuki; Thyreau, Benjamin; Kinomura, Shigeo; Sato, Kazunori; Goto, Ryoi; Kawashima, Ryuta; Fukuda, Hiroshi

    2011-01-01

    To determine the relationship between age and gray matter structure and how interactions between gender and hemisphere impact this relationship, we examined correlations between global or regional gray matter volume and age, including interactions of gender and hemisphere, using a general linear model with voxel-based and region-of-interest analyses. Brain magnetic resonance images were collected from 1460 healthy individuals aged 20–69 years; the images were linearly normalized and segmented and restored to native space for analysis of global gray matter volume. Linearly normalized images were then non-linearly normalized and smoothed for analysis of regional gray matter volume. Analysis of global gray matter volume revealed a significant negative correlation between gray matter ratio (gray matter volume divided by intracranial volume) and age in both genders, and a significant interaction effect of age × gender on the gray matter ratio. In analyzing regional gray matter volume, the gray matter volume of all regions showed significant main effects of age, and most regions, with the exception of several including the inferior parietal lobule, showed a significant age × gender interaction. Additionally, the inferior temporal gyrus showed a significant age × gender × hemisphere interaction. No regional volumes showed significant age × hemisphere interactions. Our study may contribute to clarifying the mechanism(s) of normal brain aging in each brain region. PMID:21818377

  9. Pineal Gland Volume Assessed by MRI and Its Correlation with 6-Sulfatoxymelatonin Levels among Older Men.

    PubMed

    Sigurdardottir, Lara G; Markt, Sarah C; Sigurdsson, Sigurdur; Aspelund, Thor; Fall, Katja; Schernhammer, Eva; Rider, Jennifer R; Launer, Lenore; Harris, Tamara; Stampfer, Meir J; Gudnason, Vilmundur; Czeisler, Charles A; Lockley, Steven W; Valdimarsdottir, Unnur A; Mucci, Lorelei A

    2016-10-01

    The pineal gland produces the hormone melatonin, and its volume may influence melatonin levels. We describe an innovative method for estimating pineal volume in humans and present the association of pineal parenchyma volume with levels of the primary melatonin metabolite, 6-sulfatoxymelatonin. We selected a random sample of 122 older Icelandic men nested within the AGES-Reykjavik cohort and measured their total pineal volume, their parenchyma volume, and the extent of calcification and cysts. For volume estimations we used manual segmentation of magnetic resonance images in the axial plane with simultaneous side-by-side view of the sagittal and coronal plane. We used multivariable adjusted linear regression models to estimate the association of pineal parenchyma volume and baseline characteristics, including 6-sulfatoxymelatonin levels. We used logistic regression to test for differences in first morning urinary 6-sulfatoxymelatonin levels among men with or without cystic or calcified glands. The pineal glands varied in volume, shape, and composition. Cysts were present in 59% of the glands and calcifications in 21%. The mean total pineal volume measured 207 mm(3) (range 65-536 mm(3)) and parenchyma volume 178 mm(3) (range 65-503 mm(3)). In multivariable-adjusted models, pineal parenchyma volume was positively correlated with 6-sulfatoxymelatonin levels (β = 0.52, p < 0.001). Levels of 6-sulfatoxymelatonin did not differ significantly by presence of cysts or calcification. By using an innovative method for pineal assessment, we found pineal parenchyma volume to be positively correlated with 6-sulfatoxymelatonin levels, in line with other recent studies.

  10. Euclidean supergravity and multi-centered solutions

    NASA Astrophysics Data System (ADS)

    Sabra, W. A.

    2017-04-01

    In ungauged supergravity theories, the no-force condition for BPS states implies the existence of stable static multi-centered solutions. The first solutions to Einstein-Maxwell theory with a positive cosmological constant describing an arbitrary number of charged black holes were found by Kastor and Traschen. Generalisations to five and higher dimensional theories were obtained by London. Multi-centered solutions in gauged supergravity, even with time-dependence allowed, have yet to be constructed. In this letter we construct supersymmetry-preserving multi-centered solutions for the case of D = 5, N = 2 Euclidean gauged supergravity coupled to an arbitrary number of vector multiplets. Higher dimensional Einstein-Maxwell multi-centered solutions are also presented.

  11. Lattice reduction using a Euclidean algorithm.

    PubMed

    Mujica, A

    2017-01-01

    The need to reduce a periodic structure given in terms of a large supercell and associated lattice generators arises frequently in different fields of application of crystallography, in particular in the ab initio theoretical modelling of materials at the atomic scale. This paper considers the reduction of crystals and addresses the reduction associated with the existence of a commensurate translation that leaves the crystal invariant, providing a practical scheme for it. The reduction procedure hinges on a convenient integer factorization of the full period of the cycle (or grid) generated by the repeated applications of the invariant translation, and its iterative reduction into sub-cycles, each of which corresponds to a factor in the decomposition of the period. This is done in successive steps, each time solving a Diophantine linear equation by means of a Euclidean reduction algorithm in order to provide the generators of the reduced lattice.

  12. Shape Selection in Non-Euclidean Plates

    NASA Astrophysics Data System (ADS)

    Gemmer, John; Venkataramani, Shankar

    2010-03-01

    We present a theoretical study of free non-Euclidean plates with a disc geometry and a prescribed metric that corresponds to a constant negative Gaussian curvature. We take the equilibrium configuration taken by the these sheets to be a minimum of a F"oppel Von-Kàrmàn type functional in which configurations free of any in plane stretching correspond to isometric embeddings of the metric. We show for all radii there exists low bending energy configurations free of any in plane stretching that obtain a periodic profile. The number of periods in these configurations is set by the condition that the principle curvatures of the surface remain finite and grows approximately exponentially with the radius of the disc.

  13. Tunneling through nonstationary barriers and Euclidean resonance

    SciTech Connect

    Ivlev, B.

    2004-09-01

    The phenomenon of Euclidean resonance (a strong enhancement of quantum tunneling through a nonstationary potential barrier) is applied to disintegration of atoms and molecules through tunnel barriers formed by applied constant and time-dependent electric fields. There are two different channels for such disintegration, electronic and ionic. The electronic mechanism is associated with the ionization of a molecule into an electron and a positive ion. The required frequencies are in a wide range between 100 MHz and the infrared. This mechanism may constitute a method of selective destruction of chemical bonds. The ionic mechanism consists of dissociation of a molecule into two ions. Since an ion is more massive than an electron, the necessary frequency is about 1 MHz. This provides the theoretical possibility of a different method of isotope separation by radio frequency waves.

  14. Euclidean lattice simulation for dynamical supersymmetry breaking

    SciTech Connect

    Kanamori, Issaku; Suzuki, Hiroshi; Sugino, Fumihiko

    2008-05-01

    The global supersymmetry is spontaneously broken if and only if the ground-state energy is strictly positive. We propose to use this fact to observe the spontaneous supersymmetry breaking in Euclidean lattice simulations. For lattice formulations that possess a manifest fermionic symmetry, there exists a natural choice of a Hamiltonian operator that is consistent with a topological property of the Witten index. We confirm validity of our idea in models of the supersymmetric quantum mechanics. We then examine a possibility of a dynamical supersymmetry breaking in the two-dimensional N=(2,2) super Yang-Mills theory with the gauge group SU(2), for which the Witten index is unknown. Differently from a recent conjectural claim, our numerical result tempts us to conclude that supersymmetry is not spontaneously broken in this system.

  15. Correlation between tumor regression grade and rectal volume in neoadjuvant concurrent chemoradiotherapy for rectal cancer

    PubMed Central

    Lee, Hong Seok; Choi, Doo Ho; Park, Hee Chul; Park, Won; Yu, Jeong Il; Chung, Kwangzoo

    2016-01-01

    Purpose To determine whether large rectal volume on planning computed tomography (CT) results in lower tumor regression grade (TRG) after neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer patients. Materials and Methods We reviewed medical records of 113 patients treated with surgery following neoadjuvant CCRT for rectal cancer between January and December 2012. Rectal volume was contoured on axial images in which gross tumor volume was included. Average axial rectal area (ARA) was defined as rectal volume divided by longitudinal tumor length. The impact of rectal volume and ARA on TRG was assessed. Results Average rectal volume and ARA were 11.3 mL and 2.9 cm². After completion of neoadjuvant CCRT in 113 patients, pathologic results revealed total regression (TRG 4) in 28 patients (25%), good regression (TRG 3) in 25 patients (22%), moderate regression (TRG 2) in 34 patients (30%), minor regression (TRG 1) in 24 patients (21%), and no regression (TRG0) in 2 patients (2%). No difference of rectal volume and ARA was found between each TRG groups. Linear correlation existed between rectal volume and TRG (p = 0.036) but not between ARA and TRG (p = 0.058). Conclusion Rectal volume on planning CT has no significance on TRG in patients receiving neoadjuvant CCRT for rectal cancer. These results indicate that maintaining minimal rectal volume before each treatment may not be necessary. PMID:27592514

  16. Neuroanatomical correlates of intelligence in healthy young adults: the role of basal ganglia volume.

    PubMed

    Rhein, Cosima; Mühle, Christiane; Richter-Schmidinger, Tanja; Alexopoulos, Panagiotis; Doerfler, Arnd; Kornhuber, Johannes

    2014-01-01

    In neuropsychiatric diseases with basal ganglia involvement, higher cognitive functions are often impaired. In this exploratory study, we examined healthy young adults to gain detailed insight into the relationship between basal ganglia volume and cognitive abilities under non-pathological conditions. We investigated 137 healthy adults that were between the ages of 21 and 35 years with similar educational backgrounds. Magnetic resonance imaging (MRI) was performed, and volumes of basal ganglia nuclei in both hemispheres were calculated using FreeSurfer software. The cognitive assessment consisted of verbal, numeric and figural aspects of intelligence for either the fluid or the crystallised intelligence factor using the intelligence test Intelligenz-Struktur-Test (I-S-T 2000 R). Our data revealed significant correlations of the caudate nucleus and pallidum volumes with figural and numeric aspects of intelligence, but not with verbal intelligence. Interestingly, figural intelligence associations were dependent on sex and intelligence factor; in females, the pallidum volumes were correlated with crystallised figural intelligence (r = 0.372, p = 0.01), whereas in males, the caudate volumes were correlated with fluid figural intelligence (r = 0.507, p = 0.01). Numeric intelligence was correlated with right-lateralised caudate nucleus volumes for both females and males, but only for crystallised intelligence (r = 0.306, p = 0.04 and r = 0.459, p = 0.04, respectively). The associations were not mediated by prefrontal cortical subfield volumes when controlling with partial correlation analyses. The findings of our exploratory analysis indicate that figural and numeric intelligence aspects, but not verbal aspects, are strongly associated with basal ganglia volumes. Unlike numeric intelligence, the type of figural intelligence appears to be related to distinct basal ganglia nuclei in a sex-specific manner. Subcortical brain structures thus may contribute substantially to

  17. Neuroanatomical Correlates of Intelligence in Healthy Young Adults: The Role of Basal Ganglia Volume

    PubMed Central

    Rhein, Cosima; Mühle, Christiane; Richter-Schmidinger, Tanja; Alexopoulos, Panagiotis; Doerfler, Arnd; Kornhuber, Johannes

    2014-01-01

    Background In neuropsychiatric diseases with basal ganglia involvement, higher cognitive functions are often impaired. In this exploratory study, we examined healthy young adults to gain detailed insight into the relationship between basal ganglia volume and cognitive abilities under non-pathological conditions. Methodology/Principal Findings We investigated 137 healthy adults that were between the ages of 21 and 35 years with similar educational backgrounds. Magnetic resonance imaging (MRI) was performed, and volumes of basal ganglia nuclei in both hemispheres were calculated using FreeSurfer software. The cognitive assessment consisted of verbal, numeric and figural aspects of intelligence for either the fluid or the crystallised intelligence factor using the intelligence test Intelligenz-Struktur-Test (I-S-T 2000 R). Our data revealed significant correlations of the caudate nucleus and pallidum volumes with figural and numeric aspects of intelligence, but not with verbal intelligence. Interestingly, figural intelligence associations were dependent on sex and intelligence factor; in females, the pallidum volumes were correlated with crystallised figural intelligence (r = 0.372, p = 0.01), whereas in males, the caudate volumes were correlated with fluid figural intelligence (r = 0.507, p = 0.01). Numeric intelligence was correlated with right-lateralised caudate nucleus volumes for both females and males, but only for crystallised intelligence (r = 0.306, p = 0.04 and r = 0.459, p = 0.04, respectively). The associations were not mediated by prefrontal cortical subfield volumes when controlling with partial correlation analyses. Conclusions/Significance The findings of our exploratory analysis indicate that figural and numeric intelligence aspects, but not verbal aspects, are strongly associated with basal ganglia volumes. Unlike numeric intelligence, the type of figural intelligence appears to be related to distinct basal ganglia

  18. Pulmonary function tests correlated with thoracic volumes in adolescent idiopathic scoliosis.

    PubMed

    Ledonio, Charles Gerald T; Rosenstein, Benjamin E; Johnston, Charles E; Regelmann, Warren E; Nuckley, David J; Polly, David W

    2017-01-01

    Scoliosis deformity has been linked with deleterious changes in the thoracic cavity that affect pulmonary function. The causal relationship between spinal deformity and pulmonary function has yet to be fully defined. It has been hypothesized that deformity correction improves pulmonary function by restoring both respiratory muscle efficiency and increasing the space available to the lungs. This research aims to correlate pulmonary function and thoracic volume before and after scoliosis correction. Retrospective correlational analysis between thoracic volume modeling from plain x-rays and pulmonary function tests was conducted. Adolescent idiopathic scoliosis patients enrolled in a multicenter database were sorted by pre-operative Total Lung Capacities (TLC) % predicted values from their Pulmonary Function Tests (PFT). Ten patients with the best and ten patients with the worst TLC values were included. Modeled thoracic volume and TLC values were compared before and 2 years after surgery. Scoliosis correction resulted in an increase in the thoracic volume for patients with the worst initial TLCs (11.7%) and those with the best initial TLCs (12.5%). The adolescents with the most severe pulmonary restriction prior to surgery strongly correlated with post-operative change in total lung capacity and thoracic volume (r(2)  = 0.839; p < 0.001). The mean increase in thoracic volume in this group was 373.1 cm(3) (11.7%) which correlated with a 21.2% improvement in TLC. Scoliosis correction in adolescents was found to increase thoracic volume and is strongly correlated with improved TLC in cases with severe restrictive pulmonary function, but no correlation was found in cases with normal pulmonary function. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:175-182, 2017.

  19. Does Height to Width Ratio Correlate with Mean Volume in Gastropods?

    NASA Astrophysics Data System (ADS)

    Barriga, R.; Seixas, G.; Payne, J.

    2012-12-01

    Marine organisms' shell shape and size show important biological information. For example, shape and size can dictate how the organism ranges for food and escapes predation. Due to lack of data and analysis, the evolution of shell size in marine gastropods (snails) remains poorly known. In this study, I attempt to find the relationship between height to width ratio and mean volume. I collected height and width measurements from primary literature sources and calculated volume from these measurements. My results indicate that there was no correlation between height to width ratio and mean volume between 500 to 200 Ma, but there was a correlation between 200 Ma to present where there is a steady increase in both height to width ratio and mean volume. This means that shell shape was not an important factor at the beginning of gastropod evolution but after 200 Ma body size evolution was increasingly driven by the height to width ratio.

  20. Correlation of right and left ventricular ejection fraction and volume measurements

    SciTech Connect

    Benedetto, A.R.; Nusynowitz, M.L.

    1988-06-01

    First-pass radiocardiography and biplane angiocardiography were performed on 13 patients with left-sided regurgitant valvular disease (R+) and 7 patients without regurgitation but with coronary artery disease and/or cardiomyopathy (R-). Right and left ventricular volumes and ejection fractions were calculated and compared. In the R- group, corresponding right and left ventricular volumes and ejection fractions correlated highly with each other (r = 0.86-0.89, p approximately equal to 0.01). Ejection fractions in the R+ group correlated (r = 0.64, p less than 0.05) only because stroke volume correlation was very high (r = 0.93), with end-diastolic and end-systolic volumes showing no significant correlation. Right ventricular ejection fraction (RVEF) decreased significantly with increasing mean pulmonary artery pressure (PAP) in both R- and R+ groups. The correlation of RVEF and LVEF in the R- group appears to be multifactorial in origin, consisting of effects of increased PAP, the mechanical interference of an enlarged left ventricle on the right ventricle, and direct biventricular ischemic effects. In the R+ group, the correlation appears to be due to only increased PAP and its sequelae.

  1. Ultrasonographic assessment of splenic volume and its correlation with body parameters in a Jordanian population

    PubMed Central

    Badran, Darwish H.; Kalbouneh, Heba M.; Al-Hadidi, Maher T.; Shatarat, Amjad T.; Tarawneh, Emad S.; Hadidy, Azmy M.; Mahafza, Waleed S.

    2015-01-01

    Objectives: To estimate normal linear dimensions and volume of spleen in Jordanians using ultrasonography, and to correlate splenic volume with age and body parameters: height, weight, body surface area (BSA), and body mass index (BMI). Methods: A prospective pilot study was conducted on 205 volunteers (115 males and 90 females) not known to have any conditions likely to be associated with splenomegaly. The study was performed at the Radiology Department, Jordanian University Hospital, Amman, Jordan, between December 2013 and August 2014. All linear dimensions of spleen were measured, and splenic volume (index) was calculated using the standard prolate ellipsoid formula (length × width × depth × 0.523). The splenic volume was then analyzed with age and body parameters using the Pearson’s correlation coefficient. Results: The mean (± SD) splenic dimensions were 10.72±1.37 cm in length, 7.40±1.52 cm in width, 4.40±1.47 cm in depth, and 184.15±79.56 cm3 in volume. Men had larger spleens than women (p<0.0001). Age had no significant effect on spleen volume (r=0.11, p=0.12). There was a significant moderate positive correlation (p<0.0001), using Pearson’s correlation coefficient, between the spleen volume, and other parameters (height, weight, BSA, and BMI), with correlation coefficients exceeding 0.3. Conclusion: A local reference of spleen dimensions was established with a different range of values reported previously. PMID:26219448

  2. Correlated Variability in the Breathing Pattern and End-Expiratory Lung Volumes in Conscious Humans

    PubMed Central

    Dellaca, Raffaele L.; Aliverti, Andrea; Lo Mauro, Antonella; Lutchen, Kenneth R.; Pedotti, Antonio; Suki, Bela

    2015-01-01

    In order to characterize the variability and correlation properties of spontaneous breathing in humans, the breathing pattern of 16 seated healthy subjects was studied during 40 min of quiet breathing using opto-electronic plethysmography, a contactless technology that measures total and compartmental chest wall volumes without interfering with the subjects breathing. From these signals, tidal volume (VT), respiratory time (TTOT) and the other breathing pattern parameters were computed breath-by-breath together with the end-expiratory total and compartmental (pulmonary rib cage and abdomen) chest wall volume changes. The correlation properties of these variables were quantified by detrended fluctuation analysis, computing the scaling exponentα. VT, TTOT and the other breathing pattern variables showed α values between 0.60 (for minute ventilation) to 0.71 (for respiratory rate), all significantly lower than the ones obtained for end-expiratory volumes, that ranged between 1.05 (for rib cage) and 1.13 (for abdomen) with no significant differences between compartments. The much stronger long-range correlations of the end expiratory volumes were interpreted by a neuromechanical network model consisting of five neuron groups in the brain respiratory center coupled with the mechanical properties of the respiratory system modeled as a simple Kelvin body. The model-based α for VT is 0.57, similar to the experimental data. While the α for TTOT was slightly lower than the experimental values, the model correctly predicted α for end-expiratory lung volumes (1.045). In conclusion, we propose that the correlations in the timing and amplitude of the physiological variables originate from the brain with the exception of end-expiratory lung volume, which shows the strongest correlations largely due to the contribution of the viscoelastic properties of the tissues. This cycle-by-cycle variability may have a significant impact on the functioning of adherent cells in the

  3. Correlated variability in the breathing pattern and end-expiratory lung volumes in conscious humans.

    PubMed

    Dellaca, Raffaele L; Aliverti, Andrea; Lo Mauro, Antonella; Lutchen, Kenneth R; Pedotti, Antonio; Suki, Bela

    2015-01-01

    In order to characterize the variability and correlation properties of spontaneous breathing in humans, the breathing pattern of 16 seated healthy subjects was studied during 40 min of quiet breathing using opto-electronic plethysmography, a contactless technology that measures total and compartmental chest wall volumes without interfering with the subjects breathing. From these signals, tidal volume (VT), respiratory time (TTOT) and the other breathing pattern parameters were computed breath-by-breath together with the end-expiratory total and compartmental (pulmonary rib cage and abdomen) chest wall volume changes. The correlation properties of these variables were quantified by detrended fluctuation analysis, computing the scaling exponenta. VT, TTOT and the other breathing pattern variables showed α values between 0.60 (for minute ventilation) to 0.71 (for respiratory rate), all significantly lower than the ones obtained for end-expiratory volumes, that ranged between 1.05 (for rib cage) and 1.13 (for abdomen) with no significant differences between compartments. The much stronger long-range correlations of the end expiratory volumes were interpreted by a neuromechanical network model consisting of five neuron groups in the brain respiratory center coupled with the mechanical properties of the respiratory system modeled as a simple Kelvin body. The model-based α for VT is 0.57, similar to the experimental data. While the α for TTOT was slightly lower than the experimental values, the model correctly predicted α for end-expiratory lung volumes (1.045). In conclusion, we propose that the correlations in the timing and amplitude of the physiological variables originate from the brain with the exception of end-expiratory lung volume, which shows the strongest correlations largely due to the contribution of the viscoelastic properties of the tissues. This cycle-by-cycle variability may have a significant impact on the functioning of adherent cells in the

  4. Minimal Paths in the City Block: Human Performance on Euclidean and Non-Euclidean Traveling Salesperson Problems

    ERIC Educational Resources Information Center

    Walwyn, Amy L.; Navarro, Daniel J.

    2010-01-01

    An experiment is reported comparing human performance on two kinds of visually presented traveling salesperson problems (TSPs), those reliant on Euclidean geometry and those reliant on city block geometry. Across multiple array sizes, human performance was near-optimal in both geometries, but was slightly better in the Euclidean format. Even so,…

  5. Minimal Paths in the City Block: Human Performance on Euclidean and Non-Euclidean Traveling Salesperson Problems

    ERIC Educational Resources Information Center

    Walwyn, Amy L.; Navarro, Daniel J.

    2010-01-01

    An experiment is reported comparing human performance on two kinds of visually presented traveling salesperson problems (TSPs), those reliant on Euclidean geometry and those reliant on city block geometry. Across multiple array sizes, human performance was near-optimal in both geometries, but was slightly better in the Euclidean format. Even so,…

  6. Gray matter volume correlates of global positive alcohol expectancy in non-dependent adult drinkers

    PubMed Central

    Ide, Jaime S.; Zhang, Sheng; Hu, Sien; Matuskey, David; Bednarski, Sarah R.; Erdman, Emily; Farr, Olivia M.; Li, Chiang-shan R.

    2013-01-01

    Alcohol use and misuse is known to involve structural brain changes. Numerous imaging studies have examined changes in gray matter (GM) volumes in dependent drinkers, but there is little information on whether non-dependent drinking is associated with structural changes and whether these changes are related to psychological factors – such as alcohol expectancy – that influence drinking behavior. We used voxel based morphometry (VBM) to examine whether the global positive scale of alcohol expectancy, as measured by the Alcohol Expectancy Questionnaire AEQ-3, is associated with specific structural markers and whether such markers are associated with drinking behavior in 113 adult non-dependent drinkers (66 women). Alcohol expectancy is positively correlated with GM volume of left precentrral gyrus (PCG) in men and women combined and bilateral superior frontal gyri (SFG) in women, and negatively correlated with GM volume of the right ventral putamen in men. Furthermore, mediation analyses showed that the GM volume of PCG mediate the correlation of alcohol expectancy and the average number of drinks consumed per occasion and monthly total number of drinks in the past year. When recent drinking was directly accounted for in multiple regressions, GM volume of bilateral dorsolateral prefrontal cortices (DLPFC) correlated positively with alcohol expectancy in the combined sample. To our knowledge, these results are the first to identify the structural brain correlates of alcohol expectancy and its mediation of drinking behaviors. These findings suggest that more studies are needed to investigate increased GM volume in the frontal cortices as a neural correlate of alcohol expectancy. PMID:23461484

  7. Morphology and function: MR pineal volume and melatonin level in human saliva are correlated.

    PubMed

    Liebrich, Luisa-Sophie; Schredl, Michael; Findeisen, Peter; Groden, Christoph; Bumb, Jan Malte; Nölte, Ingo S

    2014-10-01

    To investigate the relation between circadian saliva melatonin levels and pineal volume as determined by MRI. Plasma melatonin levels follow a circadian rhythm with a high interindividual variability. In 103 healthy individuals saliva melatonin levels were determined at four time points within 24 h and MRI was performed once (3.0 Tesla, including three-dimensional T2 turbo spin echo [3D-T2-TSE], susceptibility-weighted imaging [SWI]). Pineal volume as well as cyst volume were assessed from multiplanar reconstructed 3D-T2-TSE images. Pineal calcification volume tissue was determined on SWI. To correct for hormonal inactive pineal tissue, cystic and calcified areas were excluded. Sleep quality was assessed with the Landeck Inventory for sleep quality disturbance. Solid and uncalcified pineal volume correlated to melatonin maximum (r = 0.28; P < 0.05) and area under the curve (r = 0.29; P < 0.05). Of interest, solid and uncalcified pineal volume correlated negatively with the sleep rhythm disturbances subscore (r = -0.17; P < 0.05) despite a very homogenous population. Uncalcified solid pineal tissue measured by 3D-T2-TSE and SWI is related to human saliva melatonin levels. The analysis of the sleep quality and pineal volume suggests a linkage between better sleep quality and hormonal active pineal tissue. © 2013 Wiley Periodicals, Inc.

  8. Correlation between annual volume of cystectomy, professional staffing, and outcomes: a statewide, population-based study.

    PubMed

    Elting, Linda S; Pettaway, Curtis; Bekele, B Nebiyou; Grossman, H Barton; Cooksley, Catherine; Avritscher, Elenir B C; Saldin, Kamaldeen; Dinney, Colin P N

    2005-09-01

    The association between high procedure volume and lower perioperative mortality is well established among cancer patients who undergo cystectomy. However, to the authors' knowledge, the association between volume and perioperative complications has not been studied to date and hospital characteristics contributing to the volume-outcome correlation are unknown. In the current study, the authors studied these associations, emphasizing hospital factors that contribute to the volume-outcome correlation. Multiple-variable models of inpatient mortality and complications were developed among all 1302 bladder carcinoma patients who underwent cystectomy between January 1, 1999 and December 31, 2001 in all Texas hospitals. General estimating equations were used to adjust for clustering within the 133 hospitals. Data were obtained from hospital claims, the 2000 U.S. Census, and databases from the Center for Medicare and Medicaid Services and the American Hospital Association. Complications were reported to occur in 12% of patients, 2.2% of whom died. Mortality was higher in low-volume hospitals compared with high-volume hospitals (3.1% vs. 0.7%; P < 0.001); mortality in moderate-volume hospitals was reported to be intermediate (2.9%). After adjustment for advanced age and comorbid conditions, treatment in high-volume hospitals was associated with lower risks of mortality (odds ratio [OR] = 0.35; P = 0.02) and complications (OR = 0.53; P = 0.01). Hospitals with a high registered nurse-to-patient ratio also had a lower mortality risk (OR = 0.43; P = 0.04). Mortality after cystectomy was found to be significantly lower in high-volume hospitals, regardless of patient age. Referral to a hospital performing greater than 10 cystectomies annually is indicated for all patients. However, patients with poor access to a high-volume hospital may derive similar benefit from treatment at a hospital with a high-registered nurse-to-patient ratio. This finding requires further confirmation.

  9. [Olfactory dysfunction: correlation of olfactory bulb volume on MRI and objective olfactometry].

    PubMed

    Bauknecht, H-C; Jach, C; Fleiner, F; Sedlmaier, B; Göktas, O

    2010-02-01

    To define the role of olfactory bulb volume measurement by magnetic resonance imaging (MRI) for detecting olfactory dysfunction in comparison with objective olfactometry. Thirty patients with suspected olfactory dysfunction (16 women, 14 men; mean age 52 years, range 20 - 79 years) were examined by MRI and objective olfactometry between January 2006 and January 2009. Olfactory bulb volumes were measured by two neuroradiologists using 3D MR data sets. The olfactory function was categorized as normosmia, hyposmia, and anosmia on the basis of objective olfactometry. Pearson correlation coefficients were calculated for objective olfactometry and olfactory bulb volumes on MRI. ROC analysis was performed to determine whether MRI bulb volumes can serve to predict anosmia or hyposmia. The bulb volumes measured by MRI ranged from 0 to 135.9 mm (3). Based on olfactometry, anosmia was present in 11 patients (total bulb volume of 15.7 +/- 23.3 mm (3)), hyposmia in 9 patients (total bulb volume of 50.0 +/- 25.5 mm (3)), and normosmia in 10 patients (total bulb volume of 110.7 +/- 21.5 mm (3)). There was good correlation (r > 0.9) between objective olfactometry and olfactory bulb volume on MRI. ROC analysis yielded a cut-off value of 32 mm (3) for anosmia, which had a sensitivity of 0.91 and specificity of 0.947. The cut-off value for olfactory dysfunction was 80.7 mm (3) (sensitivity 0.95; specificity of 0.9). The olfactory bulb volume determined by MRI is a suitable parameter for diagnosing complete or partial loss of the sense of smell.

  10. Correlation between brain volume loss and clinical and MRI outcomes in multiple sclerosis

    PubMed Central

    Radue, Ernst-Wilhelm; Barkhof, Frederik; Sprenger, Till; Häring, Dieter A.; de Vera, Ana; von Rosenstiel, Philipp; Bright, Jeremy R.; Francis, Gordon; Cohen, Jeffrey A.

    2015-01-01

    Objective: We investigated the determinants and clinical correlations of MRI-detected brain volume loss (BVL) among patients with relapsing-remitting multiple sclerosis from the phase 3 trials of fingolimod: FREEDOMS, FREEDOMS II, and TRANSFORMS. Methods: Post hoc analyses were conducted in the intent-to-treat populations from each trial and in a combined dataset of 3,635 patients from the trials and their extensions. The relationship between brain volume changes and demographic, clinical, and MRI parameters was studied in pairwise correlations (Pearson) and in multiple regression models. The relative frequency of confirmed disability progression was evaluated in the combined dataset by strata of concurrent BVL at up to 4 years. Results: Increasing age, disease duration, T2 lesion volume, T1-hypointense lesion volume, and disability were associated with reduced brain volume (p < 0.001, all). The strongest individual baseline predictors of on-study BVL were T2 lesion volume, gadolinium-enhancing lesion count, and T1-hypointense lesion volume (p < 0.01, all). During each study, BVL correlated most strongly with cumulative gadolinium-enhancing lesion count, new/enlarged T2 lesion count (p < 0.001, both), and number of confirmed on-study relapses (p < 0.01). Over 4 years in the combined dataset (mean exposure to study drug, 2.4 years), confirmed disability progression was most frequent in patients with greatest BVL. Conclusions: Rate of BVL in patients during the fingolimod trials correlated with disease severity at baseline and new disease activity on study, and was associated with worsening disability. PMID:25632085

  11. RELAP5/MOD3 code manual. Volume 4, Models and correlations

    SciTech Connect

    1995-08-01

    The RELAP5 code has been developed for best-estimate transient simulation of light water reactor coolant systems during postulated accidents. The code models the coupled behavior of the reactor coolant system and the core for loss-of-coolant accidents and operational transients such as anticipated transient without scram, loss of offsite power, loss of feedwater, and loss of flow. A generic modeling approach is used that permits simulating a variety of thermal hydraulic systems. Control system and secondary system components are included to permit modeling of plant controls, turbines, condensers, and secondary feedwater systems. RELAP5/MOD3 code documentation is divided into seven volumes: Volume I presents modeling theory and associated numerical schemes; Volume II details instructions for code application and input data preparation; Volume III presents the results of developmental assessment cases that demonstrate and verify the models used in the code; Volume IV discusses in detail RELAP5 models and correlations; Volume V presents guidelines that have evolved over the past several years through the use of the RELAP5 code; Volume VI discusses the numerical scheme used in RELAP5; and Volume VII presents a collection of independent assessment calculations.

  12. Diffusion tensor imaging correlates with lesion volume in cerebral hemisphere infarctions.

    PubMed

    Rossi, Maija E; Jason, Eeva; Marchesotti, Silvia; Dastidar, Prasun; Ollikainen, Jyrki; Soimakallio, Seppo

    2010-09-17

    Both a large lesion volume and abnormalities in diffusion tensor imaging are independently associated with a poor prognosis after cerebral infarctions. Therefore, we assume that they are associated. This study assessed the associations between lesion volumes and diffusion tensor imaging in patients with a right-sided cerebral infarction. The lesion volumes of 33 patients (age 65.9 ± 8.7, 26 males and 7 females) were imaged using computed tomography (CT) in the acute phase (within 3-4 hours) and magnetic resonance imaging (MRI) in the chronic phase (follow-up at 12 months, with a range of 8-27 months). The chronic-phase fractional anisotropy (FA) and mean diffusivity (MD) values were measured at the site of the infarct and selected white matter tracts. Neurological tests in both the acute and chronic phases, and DTI lateralization were assessed with the Wilcoxon signed-rank test. The effects of thrombolytic therapy (n = 10) were assessed with the Mann-Whitney U test. The correlations between the measured parameters were analysed with Spearman's rho correlation. Bonferroni post-hoc correction was used to compensate for the familywise error rate in multiple comparisons. Several MD values in the right hemisphere correlated positively and FA values negatively with the lesion volumes. These correlations included both lesion area and healthy tissue. The results of the mini-mental state examination and the National Institutes of Health Stroke Scale also correlated with the lesion volume. A larger infarct volume is associated with more pronounced tissue modifications in the chronic stage as observed with the MD and FA alterations.

  13. Cosmetic surgery volume and its correlation with the major US stock market indices.

    PubMed

    Gordon, Chad R; Pryor, Landon; Afifi, Ahmed M; Benedetto, Paul X; Langevin, C J; Papay, Francis; Yetman, Randall; Zins, James E

    2010-01-01

    As a consumer-driven industry, cosmetic plastic surgery is subject to ebbs and flows as the economy changes. There have been many predictions about the short, intermediate, and long-term impact on cosmetic plastic surgery as a result of difficulties in the current economic climate, but no studies published in the literature have quantified a direct correlation. The authors investigate a possible correlation between cosmetic surgery volume and the economic trends of the three major US stock market indices. A volume analysis for the time period from January 1992 to October 2008 was performed (n = 7360 patients, n = 8205 procedures). Four cosmetic procedures-forehead lift (FL), rhytidectomy (Rh), breast augmentation (BA), and liposuction (Li)-were chosen; breast reduction (BRd), breast reconstruction (BRc), and carpal tunnel release (CTR) were selected for comparison. Case volumes for each procedure and fiscal quarter were compared to the trends of the S&P 500, Dow Jones (DOW), and NASDAQ (NASD) indices. Pearson correlation statistics were used to evaluate a relationship between the market index trends and surgical volume. P values <.05 were considered statistically significant. Three of the four cosmetic surgery procedures investigated (Rh, n = 1540; Li, n = 1291; BA, n = 1959) demonstrated a direct (ie, positive) statistical correlation to all three major market indices. FL (n =312) only correlated to the NASD (P = .021) and did not reach significance with the S&P 500 (P = .077) or DOW (P = .14). BRd and BRc demonstrated a direct correlation to two of the three stock market indices, whereas CTR showed an inverse (ie, negative) correlation to two of the three indices. This study, to our knowledge, is the first to suggest a direct correlation of four cosmetic and two reconstructive plastic surgery procedures to the three major US stock market indices and further emphasizes the importance of a broad-based plastic surgery practice in times of economic recession.

  14. Parental Praise Correlates with Posterior Insular Cortex Gray Matter Volume in Children and Adolescents

    PubMed Central

    Matsudaira, Izumi; Yokota, Susumu; Hashimoto, Teruo; Takeuchi, Hikaru; Asano, Kohei; Asano, Michiko; Sassa, Yuko; Taki, Yasuyuki; Kawashima, Ryuta

    2016-01-01

    A positive parenting style affects psychological and cognitive development in children. Neuroimaging studies revealed that a positive parenting style influenced brain structure in children. Parental praise is a concrete behavior observed in positive parenting. Although previous psychological studies revealed a positive effect of parental praise on children, little is known about the relationship between parental praise and brain structure in children. Thus, the purpose of the present study was to determine whether there was a correlation between the parental attitude towards praising their child and gray matter volume in the children (116 boys and 109 girls; mean age, 10.6 years old). We examined the correlation between regional gray matter volume and parental praise using voxel-based morphometry (VBM) following magnetic resonance imaging (MRI). In addition, to confirm the positive effects of parental praise, we analyzed the correlation between the frequency of parental praise and personality traits in children. We showed that the parental attitude towards praising their child was significantly and positively correlated with the gray matter volume of the left posterior insular cortex in children. Moreover, we found a significant positive correlation between parental attitude towards praising their child and the personality traits of conscientiousness and openness to experience in the children. Prior studies said that gray matter volume in the posterior insula was correlated with empathy, and the functional connectivity between this area and the amygdala was associated with emotional regulation. Furthermore, the posterior insula relates to auditory function, and therefore, was likely involved in the processing of parental praise. Considering the possibility of experience-dependent plasticity, frequent parental praise would lead to increased posterior insular gray matter volume in children. Our study is the first to elucidate the relationship between a specific

  15. Parental Praise Correlates with Posterior Insular Cortex Gray Matter Volume in Children and Adolescents.

    PubMed

    Matsudaira, Izumi; Yokota, Susumu; Hashimoto, Teruo; Takeuchi, Hikaru; Asano, Kohei; Asano, Michiko; Sassa, Yuko; Taki, Yasuyuki; Kawashima, Ryuta

    2016-01-01

    A positive parenting style affects psychological and cognitive development in children. Neuroimaging studies revealed that a positive parenting style influenced brain structure in children. Parental praise is a concrete behavior observed in positive parenting. Although previous psychological studies revealed a positive effect of parental praise on children, little is known about the relationship between parental praise and brain structure in children. Thus, the purpose of the present study was to determine whether there was a correlation between the parental attitude towards praising their child and gray matter volume in the children (116 boys and 109 girls; mean age, 10.6 years old). We examined the correlation between regional gray matter volume and parental praise using voxel-based morphometry (VBM) following magnetic resonance imaging (MRI). In addition, to confirm the positive effects of parental praise, we analyzed the correlation between the frequency of parental praise and personality traits in children. We showed that the parental attitude towards praising their child was significantly and positively correlated with the gray matter volume of the left posterior insular cortex in children. Moreover, we found a significant positive correlation between parental attitude towards praising their child and the personality traits of conscientiousness and openness to experience in the children. Prior studies said that gray matter volume in the posterior insula was correlated with empathy, and the functional connectivity between this area and the amygdala was associated with emotional regulation. Furthermore, the posterior insula relates to auditory function, and therefore, was likely involved in the processing of parental praise. Considering the possibility of experience-dependent plasticity, frequent parental praise would lead to increased posterior insular gray matter volume in children. Our study is the first to elucidate the relationship between a specific

  16. Correlation between Changes in Seismicity Rates and Well Injection Volumes in Oklahoma

    NASA Astrophysics Data System (ADS)

    Gupta, A.; Baker, J.; Walsh, R.; Zoback, M. D.

    2015-12-01

    We present a statistical approach to establish correlations between locations with seismicity increase in Oklahoma and nearby well injection volumes. Seismicity rates in the state have significantly increased since approximately 2008. Fluid injection into deep wells has been theorized to be the cause of this seismicity, but the increase occurred significantly after the start of injection activities in the region. Further, injection-induced earthquakes depend on the presence and orientation of basement faults and the stress state in the region. Because of these complexities, it has been difficult to directly correlate fluid injection with seismicity. Here we show that a statistical correlation between increase in seismicity and injection volumes can be established in Oklahoma. We first employ a change point method to locate the regions where a change in seismicity rates has occurred. We then use a logistic regression model to relate the injection volumes in a region with the presence or absence of seismicity change in the region. This model is further used to evaluate the relative contribution of cumulative injection volumes and monthly injection rates to seismicity. The model can be used to identify "seismically sensitive regions" where seismicity increase has been observed with little fluid injection, and "seismically stable regions" where seismicity changes have not been observed even with high fluid injection. This information can be combined with geological information in a region, and used to make decisions about acceptable volumes for injection and to identify lower-risk regions for injection.

  17. Sex, ecology and the brain: evolutionary correlates of brain structure volumes in Tanganyikan cichlids.

    PubMed

    Gonzalez-Voyer, Alejandro; Kolm, Niclas

    2010-12-17

    Analyses of the macroevolutionary correlates of brain structure volumes allow pinpointing of selective pressures influencing specific structures. Here we use a multiple regression framework, including phylogenetic information, to analyze brain structure evolution in 43 Tanganyikan cichlid species. We analyzed the effect of ecological and sexually selected traits for species averages, the effect of ecological traits for each sex separately and the influence of sexual selection on structure dimorphism. Our results indicate that both ecological and sexually selected traits have influenced brain structure evolution. The patterns observed in males and females generally followed those observed at the species level. Interestingly, our results suggest that strong sexual selection is associated with reduced structure volumes, since all correlations between sexually selected traits and structure volumes were negative and the only statistically significant association between sexual selection and structure dimorphism was also negative. Finally, we previously found that monoparental female care was associated with increased brain size. However, here cerebellum and hypothalamus volumes, after controlling for brain size, associated negatively with female-only care. Thus, in accord with the mosaic model of brain evolution, brain structure volumes may not respond proportionately to changes in brain size. Indeed selection favoring larger brains can simultaneously lead to a reduction in relative structure volumes.

  18. Action with Acceleration i: Euclidean Hamiltonian and Path Integral

    NASA Astrophysics Data System (ADS)

    Baaquie, Belal E.

    2013-10-01

    An action having an acceleration term in addition to the usual velocity term is analyzed. The quantum mechanical system is directly defined for Euclidean time using the path integral. The Euclidean Hamiltonian is shown to yield the acceleration Lagrangian and the path integral with the correct boundary conditions. Due to the acceleration term, the state space depends on both position and velocity — and hence the Euclidean Hamiltonian depends on two degrees of freedom. The Hamiltonian for the acceleration system is non-Hermitian and can be mapped to a Hermitian Hamiltonian using a similarity transformation; the matrix elements of the similarity transformation are explicitly evaluated.

  19. A Euclidean Perspective on the Unfolding of Azurin: Spatial Correlations

    PubMed Central

    Warren, Jeffrey J.; Gray, Harry B.; Winkler, Jay R.; Kozak, John J.

    2013-01-01

    We investigate the stability to structural perturbation of Pseudomonas aeruginosa azurin using a previously developed geometric model. Our analysis considers Ru(2,2′,6′,2″-terpyridine)(1,10-phenanthroline)(His83)-labeled wild-type azurin and five variants with mutations to Cu-ligating residues. We find that in the early stages of unfolding, the β-strands exhibit the most structural stability. The conserved residues comprising the hydrophobic core are dislocated only after nearly complete unfolding of the β-barrel. Attachment of the Ru-complex at His83 does not destabilize the protein fold, despite causing some degree of structural rearrangement. Notably, replacing the Cys112 and/or Met121 Cu ligands does not affect the conformational integrity of the protein. Notably, these results are in accord with experimental evidence, as well as molecular dynamics simulations of the denaturation of azurin. PMID:23853392

  20. Creatine kinase activity weakly correlates to volume completed following upper body resistance exercise.

    PubMed

    Machado, Marco; Willardson, Jeffrey M; Silva, Dailson R; Frigulha, Italo C; Koch, Alexander J; Souza, Sergio C

    2012-06-01

    In the current study, we examined the relationship between serum creatine kinase (CK) activity following upper body resistance exercise with a 1- or 3-min rest between sets. Twenty men performed two sessions, each consisting of four sets with a 10-repetition maximum load. The results demonstrated significantly greater volume for the 3-min condition (M = 4156 kg, SD = 867, for 3 min; vs. M = 3503 kg SD = 759, for 1 min; p < .001), with no significant differences in delta CK activity between conditions (p = .574). Nevertheless, there was a weak correlation between the delta CK activity and total volume of exercise completed (r = .55 with a 1-min rest, and r = .45 with a 3-min rest). Therefore, the volume following upper body resistance exercise correlates weakly with serum CK levels, irrespective of rest interval length between sets.

  1. Correlation between Gray/White Matter Volume and Cognition in Healthy Elderly People

    ERIC Educational Resources Information Center

    Taki, Yasuyuki; Kinomura, Shigeo; Sato, Kazunori; Goto, Ryoi; Wu, Kai; Kawashima, Ryuta; Fukuda, Hiroshi

    2011-01-01

    This study applied volumetric analysis and voxel-based morphometry (VBM) of brain magnetic resonance (MR) images to assess whether correlations exist between global and regional gray/white matter volume and the cognitive functions of semantic memory and short-term memory, which are relatively well preserved with aging, using MR image data from 109…

  2. Correlation between Gray/White Matter Volume and Cognition in Healthy Elderly People

    ERIC Educational Resources Information Center

    Taki, Yasuyuki; Kinomura, Shigeo; Sato, Kazunori; Goto, Ryoi; Wu, Kai; Kawashima, Ryuta; Fukuda, Hiroshi

    2011-01-01

    This study applied volumetric analysis and voxel-based morphometry (VBM) of brain magnetic resonance (MR) images to assess whether correlations exist between global and regional gray/white matter volume and the cognitive functions of semantic memory and short-term memory, which are relatively well preserved with aging, using MR image data from 109…

  3. Dose-volume factors correlating with trismus following chemoradiation for head and neck cancer

    PubMed Central

    RAO, SHYAM D.; SALEH, ZIAD H.; SETTON, JEREMY; TAM, MOSES; MCBRIDE, SEAN M.; RIAZ, NADEEM; DEASY, JOSEPH O.; LEE, NANCY Y.

    2016-01-01

    Background To investigate the dose-volume factors in mastication muscles that are implicated as possible causes of trismus in patients following treatment with intensity-modulated radiotherapy (IMRT) and concurrent chemotherapy for head and neck cancers. Material and methods All evaluable patients treated at our institution between January 2004 and April 2009 with chemotherapy and IMRT for squamous cell cancers of the oropharynx, nasopharynx, hypopharynx or larynx were included in this analysis (N = 421). Trismus was assessed using CTCAE 4.0. Bi-lateral masseter, temporalis, lateral pterygoid and medial pterygoid muscles were delineated on axial computed tomography (CT) treatment planning images, and dose-volume parameters were extracted to investigate univariate and multimetric correlations. Results Forty-six patients (10.9%) were observed to have chronic trismus of grade 1 or greater. From analysis of baseline patient characteristics, toxicity correlated with primary site and patient age. From dose-volume analysis, the steepest dose thresholds and highest correlations were seen for mean dose to ipsilateral masseter (Spearman’s rank correlation coefficient Rs = 0.25) and medial pterygoid (Rs = 0.23) muscles. Lyman-Kutcher-Burman modeling showed highest correlations for the same muscles. The best correlation for multimetric logistic regression modeling was with V68Gy to the ipsilateral medial pterygoid (Rs = 0.29). Conclusion Chemoradiation-induced trismus remains a problem particularly for patients with oropharyngeal carcinoma. Strong dose-volume correlations support the hypothesis that limiting dose to the ipsilateral masseter muscle and, in particular, the medial pterygoid muscle may reduce the likelihood of trismus. PMID:25920361

  4. Dose-volume factors correlating with trismus following chemoradiation for head and neck cancer.

    PubMed

    Rao, Shyam D; Saleh, Ziad H; Setton, Jeremy; Tam, Moses; McBride, Sean M; Riaz, Nadeem; Deasy, Joseph O; Lee, Nancy Y

    2016-01-01

    To investigate the dose-volume factors in mastication muscles that are implicated as possible causes of trismus in patients following treatment with intensity-modulated radiotherapy (IMRT) and concurrent chemotherapy for head and neck cancers. All evaluable patients treated at our institution between January 2004 and April 2009 with chemotherapy and IMRT for squamous cell cancers of the oropharynx, nasopharynx, hypopharynx or larynx were included in this analysis (N = 421). Trismus was assessed using CTCAE 4.0. Bi-lateral masseter, temporalis, lateral pterygoid and medial pterygoid muscles were delineated on axial computed tomography (CT) treatment planning images, and dose-volume parameters were extracted to investigate univariate and multimetric correlations. Forty-six patients (10.9%) were observed to have chronic trismus of grade 1 or greater. From analysis of baseline patient characteristics, toxicity correlated with primary site and patient age. From dose-volume analysis, the steepest dose thresholds and highest correlations were seen for mean dose to ipsilateral masseter (Spearman's rank correlation coefficient Rs = 0.25) and medial pterygoid (Rs = 0.23) muscles. Lyman-Kutcher-Burman modeling showed highest correlations for the same muscles. The best correlation for multimetric logistic regression modeling was with V68Gy to the ipsilateral medial pterygoid (Rs = 0.29). Chemoradiation-induced trismus remains a problem particularly for patients with oropharyngeal carcinoma. Strong dose-volume correlations support the hypothesis that limiting dose to the ipsilateral masseter muscle and, in particular, the medial pterygoid muscle may reduce the likelihood of trismus.

  5. Left medial orbitofrontal cortex volume correlates with skydive-elicited euphoric experience.

    PubMed

    Carlson, Joshua M; Cha, Jiook; Fekete, Tomer; Greenberg, Tsafrir; Mujica-Parodi, Lilianne R

    2016-11-01

    The medial orbitofrontal cortex has been linked to the experience of positive affect. Greater medial orbitofrontal cortex volume is associated with greater expression of positive affect and reduced medial orbital frontal cortex volume is associated with blunted positive affect. However, little is known about the experience of euphoria, or extreme joy, and how this state may relate to variability in medial orbitofrontal cortex structure. To test the hypothesis that variability in euphoric experience correlates with the volume of the medial orbitofrontal cortex, we measured individuals' (N = 31) level of self-reported euphoria in response to a highly anticipated first time skydive and measured orbitofrontal cortical volumes with structural magnetic resonance imaging. Skydiving elicited a large increase in self-reported euphoria. Participants' euphoric experience was predicted by the volume of their left medial orbitofrontal cortex such that, the greater the volume, the greater the euphoria. Further analyses indicated that the left medial orbitofrontal cortex and amygdalo-hippocampal complex independently explain variability in euphoric experience and that medial orbitofrontal cortex volume, in conjunction with other structures within the mOFC-centered corticolimbic circuit, can be used to predict individuals' euphoric experience.

  6. Does Prostate Volume Correlate with Vitamin D Deficiency Among Men Undergoing Prostate Biopsy?

    PubMed Central

    Murphy, Adam B.; Nyame, Yaw A.; Batai, Ken; Khan, Asfandyar; Gogana, Pooja; Dixon, Michael; Macias, Virgilia; Kajdacsy-Balla, Andre; Hollowell, Courtney M.P.; Catalona, William J.; Kittles, Rick

    2016-01-01

    Objectives Recent studies demonstrate vitamin D is inversely correlated with benign prostatic hyperplasia (BPH) and prostate cancer (PCa) incidence. We aim to clarify the associations of vitamin D with prostate volume. Methods This is an observational study investigating the associations of serum PSA, PSA Density (PSAD) and prostate volume with serum 25-hydroxyvitamin D (25-OH D) in PCa patients and men with negative biopsies seen in outpatient urology clinics in Chicago, IL. There were 571 men (40- to 79-years-old) with elevated PSA or abnormal digital rectal examination (DRE) with available prostate volume recorded from initial biopsy. The primary outcomes were the unadjusted associations of serum 25-hydroxyvitamin D deficiency with prostate volume. The secondary outcomes were the adjusted associations using linear and logistic regression analysis. Results On univariate analysis, serum 25-OH D < 20ng/ml inversely correlated with prostate volume among all men undergoing transrectal ultrasonography (p = 0.02), and this relationship remained significant for men with negative biopsy on stratified analysis. In adjusted models, controlling for age, serum PSA, 5-ARI use, obesity, and PCa diagnosis, prostate volume was inversely associated with vitamin D (p < 0.05) using serum vitamin D as a continuous and categorical variable. Logistic regression model also demonstrated an inverse association between vitamin D (continuous and categorical) and prostate volume ≥ 40 grams. Conclusion Serum 25-OH D levels are inversely associated with overall prostate volume and enlarged prostate gland (≥ 40 grams), especially in men with benign prostatic disease. Given the largely non-toxic effect of supplementation, consideration should be given to assessing vitamin D levels in men with benign prostatic disease in addition, to malignant prostatic disease. PMID:27725729

  7. Non-Euclidean properties of spike train metric spaces

    NASA Astrophysics Data System (ADS)

    Aronov, Dmitriy; Victor, Jonathan D.

    2004-06-01

    Quantifying the dissimilarity (or distance) between two sequences is essential to the study of action potential (spike) trains in neuroscience and genetic sequences in molecular biology. In neuroscience, traditional methods for sequence comparisons rely on techniques appropriate for multivariate data, which typically assume that the space of sequences is intrinsically Euclidean. More recently, metrics that do not make this assumption have been introduced for comparison of neural activity patterns. These metrics have a formal resemblance to those used in the comparison of genetic sequences. Yet the relationship between such metrics and the traditional Euclidean distances has remained unclear. We show, both analytically and computationally, that the geometries associated with metric spaces of event sequences are intrinsically non-Euclidean. Our results demonstrate that metric spaces enrich the study of neural activity patterns, since accounting for perceptual spaces requires a non-Euclidean geometry.

  8. Infinitesimal rigidity of hyperquadrics in semi-Euclidean space

    NASA Astrophysics Data System (ADS)

    Shin, An Sook; Kim, Hobum; Han, Hyelim

    2016-12-01

    In this paper, we show that hyperquadrics are infinitesimally rigid in a semi-Euclidean space. We also show that hypersurfaces of hyperquadrics cut by hyperplanes not passing through the origin are infinitesimally rigid in the hyperquadrics, whereas those cut by hyperplanes through the origin are not infinitesimally rigid in hyperquadrics. Furthermore, we prove that any hypersurface in a semi-Euclidean space containing some open subset of a hyperplane is not infinitesimally rigid.

  9. Improving the clinical correlation of multiple sclerosis black hole volume change by paired-scan analysis.

    PubMed

    Tam, Roger C; Traboulsee, Anthony; Riddehough, Andrew; Li, David K B

    2012-01-01

    The change in T 1-hypointense lesion ("black hole") volume is an important marker of pathological progression in multiple sclerosis (MS). Black hole boundaries often have low contrast and are difficult to determine accurately and most (semi-)automated segmentation methods first compute the T 2-hyperintense lesions, which are a superset of the black holes and are typically more distinct, to form a search space for the T 1w lesions. Two main potential sources of measurement noise in longitudinal black hole volume computation are partial volume and variability in the T 2w lesion segmentation. A paired analysis approach is proposed herein that uses registration to equalize partial volume and lesion mask processing to combine T 2w lesion segmentations across time. The scans of 247 MS patients are used to compare a selected black hole computation method with an enhanced version incorporating paired analysis, using rank correlation to a clinical variable (MS functional composite) as the primary outcome measure. The comparison is done at nine different levels of intensity as a previous study suggests that darker black holes may yield stronger correlations. The results demonstrate that paired analysis can strongly improve longitudinal correlation (from -0.148 to -0.303 in this sample) and may produce segmentations that are more sensitive to clinically relevant changes.

  10. Prostate Volumes Derived From MRI and Volume-Adjusted Serum Prostate-Specific Antigen: Correlation With Gleason Score of Prostate Cancer

    PubMed Central

    Karademir, Ibrahim; Shen, Dinggang; Peng, Yahui; Liao, Shu; Jiang, Yulei; Yousuf, Ambereen; Karczmar, Gregory; Sammet, Steffen; Wang, Shiyang; Medved, Milica; Antic, Tatjana; Eggener, Scott; Oto, Aytekin

    2015-01-01

    OBJECTIVE The purpose of this article is to study relationships between MRI-based prostate volume and volume-adjusted serum prostate-specific antigen (PSA) concentration estimates and prostate cancer Gleason score. MATERIALS AND METHODS The study included 61 patients with prostate cancer (average age, 63.3 years; range 52–75 years) who underwent MRI before prostatectomy. A semiautomated and MRI-based technique was used to estimate total and central gland prostate volumes, central gland volume fraction (central gland volume divided by total prostate volume), PSA density (PSAD; PSA divided by total prostate volume), and PSAD for the central gland (PSA divided by central gland volume). These MRI-based volume and volume-adjusted PSA estimates were compared with prostatectomy specimen weight and Gleason score by using Pearson (r) or Spearman (ρ) correlation coefficients. RESULTS The estimated total prostate volume showed a high correlation with reference standard volume (r = 0.94). Of the 61 patients, eight (13.1%) had a Gleason score of 6, 40 (65.6%) had a Gleason score of 7, seven (11.5%) had a Gleason score of 8, and six (9.8%) had a Gleason score of 9 for prostate cancer. The Gleason score was significantly correlated with central gland volume fraction (ρ = −0.42; p = 0.0007), PSAD (ρ = 0.46; p = 0.0002), and PSAD for the central gland (ρ = 0.55; p = 0.00001). CONCLUSION Central gland volume fraction, PSAD, and PSAD for the central gland estimated from MRI examinations show a modest but significant correlation with Gleason score and have the potential to contribute to personalized risk assessment for significant prostate cancer. PMID:24147475

  11. Troponin T: Correlation with location and volume of acute brain infarction.

    PubMed

    Král, Michal; Šaňák, Daniel; Veverka, Tomáš; Hutyra, Martin; Vindiš, David; Bártková, Andrea; Kunčarová, Anna; Dorňák, Tomáš; Čecháková, Eva; Herzig, Roman; Langová, Kateřina; Kaňovský, Petr; Školoudík, David

    2015-02-15

    The troponin T (cTnT) is frequently elevated in acute ischemic stroke (AIS) patients. However, the relationship, if any, between the cTnT level and brain infarction remains to be established. The aim was to investigate the possible correlation between the location and volume of brain infarction and the cardiac cTnT serum level in AIS patients. The study consisted of consecutive AIS patients admitted within 12h of stroke onset. The location and volume of the acute ischemic lesion was assessed with magnetic resonance imaging. Standard laboratory tests, including cTnT and repeated electrocardiograms, were performed at admission and after 4h. Correlations between the cTnT level and the location and volume of brain infarction and baseline parameters were tested with a Spearman correlation coefficient. Univariate and multiple logistic regression analysis (LRA) were used to determine the possible predictors of cTnT elevation. Out of the 200 enrolled patients, elevated cTnT was present in 71 (36%). No correlation was found between the cTnT serum levels and the location (P>0.05) nor volume of brain infarction (r=0.05, P=0.48). LRA identified creatinine (OR: 1.26 per 10μmol/L increase; 95% CI: 1.043-1.524), NT-proBNP (OR: 1.05 per 100μg/L increase; 95% CI: 1.018-1.093) and male gender (OR: 3.674; 95% CI: 1.025-13.164) as significant independent predictors of pathological elevation of cTnT. Although elevated cTnT serum level is relatively frequent in AIS patients within the first 12h of stroke onset, it is not related to the location or volume of brain infarction. http://www.clinicaltrials.gov (No. NCT01541163). Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  12. Cerebellar gray matter volume correlates with duration of cocaine use in cocaine-dependent subjects.

    PubMed

    Sim, Minyoung E; Lyoo, In Kyoon; Streeter, Chris C; Covell, Julie; Sarid-Segal, Ofra; Ciraulo, Domenic A; Kim, Minue J; Kaufman, Marc J; Yurgelun-Todd, Deborah A; Renshaw, Perry F

    2007-10-01

    This study was conducted to explore differences in gray and white matter volume between cocaine-dependent and healthy comparison subjects using optimized voxel-based morphometry (VBM). Brain magnetic resonance imaging (MRI) and neuropsychological function tests were performed for 40 cocaine-dependent subjects (41.4+/-6.9 years, 27 men) and 41 healthy age- and sex-matched comparison subjects (38.7+/-8.8 years, 26 men). Optimally normalized whole brain MR images were segmented, modulated, smoothed, and compared between groups with statistical parametric mapping. The cocaine-dependent group had lower gray matter volumes in bilateral premotor cortex (Brodmann area (BA) 6, 8; 16.6%), right orbitofrontal cortex (BA 10, 15.1%), bilateral temporal cortex (BA 20, 38; 15.9%), left thalamus (12.6%), and bilateral cerebellum (13.4%) as well as lower right cerebellar white matter volume (10.0%) relative to the comparison group at a corrected p<0.05 for multiple comparisons. Duration of cocaine use negatively correlated with right and left cerebellar gray matter volumes (r=-0.37, r=-0.39, respectively). In cocaine-dependent subjects, lower cerebellar hemispheric gray and white matter volumes were correlated with deficits in executive function and decreased motor performance. This study reports that cocaine-dependent subjects have lower gray matter volumes in cerebellar hemispheres as well as in frontal, temporal cortex, and thalamus. These findings are the first to suggest that the cerebellum may be vulnerable to cocaine-associated brain volume changes, and that cerebellar deficits may contribute to neuropsychological deficits and motor dysfunction frequently observed in cocaine-dependent subjects.

  13. Thigh muscle volume predicted by anthropometric measurements and correlated with physical function in the older adults.

    PubMed

    Chen, B B; Shih, T T F; Hsu, C Y; Yu, C W; Wei, S Y; Chen, C Y; Wu, C H; Chen, C Y

    2011-06-01

    (1) to correlate thigh muscle volume measured by magnetic resonance image (MRI) with anthropometric measurements and physical function in elderly subjects; (2) to predict MRI-measured thigh muscle volume using anthropometric measurements and physical functional status in elderly subjects. Cross-sectional, nonrandomized study. Outpatient clinic in Taiwan. Sixty-nine elderly subjects (33 men and 36 women) aged 65 and older. The anthropometric data (including body height, body weight, waist size, and thigh circumference), physical activity and function (including grip strength, bilateral quadriceps muscle power, the up and go test, chair rise, and five meters walk time) and bioelectrical impedance analysis data (including total body fat mass, fat-free mass, and predictive muscle size) were measured. MRI-measured muscle volume of both thighs was used as the reference standard. The MRI-measured thigh volume was positively correlated with all anthropometric data, quadriceps muscle power and the up and go test as well as fat-free mass and predictive muscle mass, whereas it was negatively associated with age and walk time. In predicting thigh muscle volume, the variables of age, gender, body weight, and thigh circumference were significant predictors in the linear regression model: Muscle volume (cm3) =4226.3-42.5 × Age (year)-955.7 × gender (male=1, female=2) + 45.9 × body weight(kg) + 60.0 × thigh circumference (cm) (r2 = 0.745, P < 0.001; standard error of the estimate = 581.6 cm3). The current work provides evidence of a strong relationship between thigh muscle volume and physical function in the elderly. We also developed a prediction equation model using anthropometric measurements. This model is a simple and noninvasive method for everyday clinical practice and follow-up.

  14. Clinical correlates of hippocampus volume and shape in antipsychotic-naïve schizophrenia.

    PubMed

    Kalmady, Sunil Vasu; Shivakumar, Venkataram; Arasappa, Rashmi; Subramaniam, Aditi; Gautham, S; Venkatasubramanian, Ganesan; Gangadhar, Bangalore N

    2017-05-30

    While volume deficit of hippocampus is an established finding in schizophrenia, very few studies have examined large sample of patients without the confounding effect of antipsychotic treatment. Concurrent evaluation of hippocampus shape will offer additional information on the hippocampal aberrations in schizophrenia. In this study, we analyzed the volume and shape of hippocampus in antipsychotic-naïve schizophrenia patients (N=71) in comparison to healthy controls (N=82). Using 3-T MRI data, gray matter (GM) volume (anterior and posterior sub-divisions) and shape of the hippocampus were analyzed. Schizophrenia patients had significant hippocampal GM volume deficits (specifically the anterior sub-division) in comparison to healthy controls. There were significant positive correlations between anterior hippocampus volume and psychopathology scores of positive syndrome. Shape analyses revealed significant inward deformation of bilateral hippocampal surface in patients. In conclusion, our study findings add robust support for volume deficit in hippocampus in antipsychotic-naïve schizophrenia. Hippocampal shape deficits in schizophrenia observed in this study map to anterior CA1 sub-region. The differential relationship of anterior hippocampus (but not posterior hippocampus) with clinical symptoms is in tune with the findings in animal models. Further systematic studies are needed to evaluate the relationship between these hippocampal gray matter deficits with white matter and functional connectivity to facilitate understanding the hippocampal network abnormalities in schizophrenia. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  15. The correlation between emotional intelligence and gray matter volume in university students.

    PubMed

    Tan, Yafei; Zhang, Qinglin; Li, Wenfu; Wei, Dongtao; Qiao, Lei; Qiu, Jiang; Hitchman, Glenn; Liu, Yijun

    2014-11-01

    A number of recent studies have investigated the neurological substrates of emotional intelligence (EI), but none of them have considered the neural correlates of EI that are measured using the Schutte Self-Report Emotional Intelligence Scale (SSREIS). This scale was developed based on the EI model of Salovey and Mayer (1990). In the present study, SSREIS was adopted to estimate EI. Meanwhile, magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) were used to evaluate the gray matter volume (GMV) of 328 university students. Results found positive correlations between Monitor of Emotions and VBM measurements in the insula and orbitofrontal cortex. In addition, Utilization of Emotions was positively correlated with the GMV in the parahippocampal gyrus, but was negatively correlated with the VBM measurements in the fusiform gyrus and middle temporal gyrus. Furthermore, Social Ability had volume correlates in the vermis. These findings indicate that the neural correlates of the EI model, which primarily focuses on the abilities of individuals to appraise and express emotions, can also regulate and utilize emotions to solve problems. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Decision-making performance in Parkinson's disease correlates with lateral orbitofrontal volume.

    PubMed

    Kobayakawa, Mutsutaka; Tsuruya, Natsuko; Kawamura, Mitsuru

    2017-01-15

    Patients with Parkinson's disease (PD) exhibit poor decision-making, and the underlying neural correlates are unclear. We used voxel-based morphometry with Diffeomorphic Anatomical Registration through Exponentiated Lie algebra to examine this issue. The decision-making abilities of 20 patients with PD and 37 healthy controls (HCs) were measured with a computerized Iowa Gambling Task (IGT). We assessed the local gray matter volumes of the patients and HCs and their correlations with decision-making performance, disease duration, disease severity, and anti-Parkinsonism medication dose. Compared with the HCs, the patients with PD exhibited poor IGT performances. The gray matter volumes in the medial orbitofrontal cortex, left inferior temporal cortex, and right middle frontal gyrus were decreased in the patients. Results in the regression analysis showed that lateral orbitofrontal volume correlated with performance in the IGT in PD. Regions that correlated with disease duration, severity, and medication dose did not overlap with orbitofrontal regions. Our results indicate that the lateral and medial orbitofrontal cortex are related to decision-making in PD patients. Since the medial orbitofrontal cortex is shown to be involved in monitoring reward, reward monitoring seems to be impaired as a whole in PD patients. Meanwhile, the lateral region is related to evaluation of punishment, which is considered to have an influence on individual differences in decision-making performance in PD patients. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Cerebral blood flow velocity positively correlates with brain volumes in long-term remitted depression.

    PubMed

    Desmidt, Thomas; Andersson, Frédéric; Brizard, Bruno; Cottier, Jean-Philippe; Patat, Frédéric; Gissot, Valérie; Belzung, Catherine; El-Hage, Wissam; Camus, Vincent

    2017-09-20

    Mechanisms involved in brain changes observed in major depression have been poorly investigated in clinical populations. Changes in cerebral blood flow (CBF) have been found in depressed patients and constitute a potential mechanism by which brain volume varies in depression. We have tested the association of cerebral blood flow velocity (CBFV) as assessed with Transcranial Doppler (TCD) and cerebral blood flow (CBF) as assessed with Arterial Spin Labeling Magnetic Resonance Imaging (ASL-MRI) with Total Brain Volume (TBV) and the volume of seven subcortical regions, in currently depressed and long-term remitted patients. In addition, we have evaluated other potential confounders for the association depression/brain volume, including dimensional symptoms of depression, cardiovascular risk factors (CVRF) and antidepressants. Seventy-five individuals were recruited, divided in 3 equal groups (currently depressed, remitted individuals and healthy controls) and were submitted to clinical assessment, MRI and Transcranial Doppler. CBFV was positively correlated with TBV, Hippocampus and Thalamus volume, but only in remitted patients, who tend to have larger brains compared to both currently depressed and controls. CVRF were negatively associated with brain volumes in the 3 groups and antidepressant use was associated with larger Thalamus. We found no association between brain volumes and CBF as assessed with ASL-MRI, anhedonia, anxiety or psychomotor retardation. Greater CBFV may be a physiological mechanism by which brain is enlarged in remitted patients. Future studies should consider CBFV, CVRF and antidepressants as possible confounders for the association depression/brain volumes, especially in remitted patients. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Correlation between free-volume parameters and physical properties of polyethylene-nitrile rubber blend

    NASA Astrophysics Data System (ADS)

    Gomaa, E.; Mostafa, N.; Mohsen, M.; Mohammed, M.

    2004-10-01

    Positron annihilation lifetime spectroscopy (PALS) was used to study the immiscibility of a polar nitrile rubber (NBR) that had been blended with pure and waste, low- and high-density polyethylene (PE). The effect of the weight percent of the rubber added to the PE was also investigated. It was found that a complicated variation (positive and negative) in both free-volume parameters (τ3 and I 3) from the values of the initial polymers forms an immiscible blend. These results are supported by a significant broadening in the free-volume hole size distributions. This has been interpreted in terms of interfacial spaces created between the boundaries of the two phases. Furthermore, a correlation was established between the free-volume parameters (τ3 and I 3) and the electrical and mechanical properties of the before mentioned polymer blends as a function of the weight percent of waste PE.

  19. Correlation Characterization of Particles in Volume Based on Peak-to-Basement Ratio

    NASA Astrophysics Data System (ADS)

    Vovk, Tatiana A.; Petrov, Nikolay V.

    2017-03-01

    We propose a new express method of the correlation characterization of the particles suspended in the volume of optically transparent medium. It utilizes inline digital holography technique for obtaining two images of the adjacent layers from the investigated volume with subsequent matching of the cross-correlation function peak-to-basement ratio calculated for these images. After preliminary calibration via numerical simulation, the proposed method allows one to quickly distinguish parameters of the particle distribution and evaluate their concentration. The experimental verification was carried out for the two types of physical suspensions. Our method can be applied in environmental and biological research, which includes analyzing tools in flow cytometry devices, express characterization of particles and biological cells in air and water media, and various technical tasks, e.g. the study of scattering objects or rapid determination of cutting tool conditions in mechanisms.

  20. Correlation Characterization of Particles in Volume Based on Peak-to-Basement Ratio

    PubMed Central

    Vovk, Tatiana A.; Petrov, Nikolay V.

    2017-01-01

    We propose a new express method of the correlation characterization of the particles suspended in the volume of optically transparent medium. It utilizes inline digital holography technique for obtaining two images of the adjacent layers from the investigated volume with subsequent matching of the cross-correlation function peak-to-basement ratio calculated for these images. After preliminary calibration via numerical simulation, the proposed method allows one to quickly distinguish parameters of the particle distribution and evaluate their concentration. The experimental verification was carried out for the two types of physical suspensions. Our method can be applied in environmental and biological research, which includes analyzing tools in flow cytometry devices, express characterization of particles and biological cells in air and water media, and various technical tasks, e.g. the study of scattering objects or rapid determination of cutting tool conditions in mechanisms. PMID:28252020

  1. Temporal variations of serial correlations of trading volume in the US stock market

    NASA Astrophysics Data System (ADS)

    Alvarez-Ramírez, José; Rodríguez, Eduardo

    2012-08-01

    Serial correlations in the trading volume of the US stock market are investigated in this paper. The use of the detrended fluctuation analysis implemented within a rolling window indicated that, for the period 1929-2011, the strength of correlations exhibits important temporal variations with a trend shift by the 1990s, and 4-year and 21-year cycles. These empirical findings are compared to those obtained for mature international stock markets (FTSE-100 and Nikkei) and discussed in terms of potential economic and financial implications.

  2. Cerebellar vermal volumes and behavioral correlates in children with autism spectrum disorder

    PubMed Central

    Webb, Sara Jane; Sparks, Bobbi-Faun; Friedman, Seth D.; Shaw, Dennis W. W.; Giedd, Jay; Dawson, Geraldine; Dager, Steven R.

    2009-01-01

    Cerebellar histopathological abnormalities have been well documented in autism although findings of structural differences, as determined by magnetic resonance imaging, have been less consistent. This report explores specific cerebellar vermal structures and their relation with symptoms severity and cognitive functioning in young children with autism spectrum disorder (ASD). Children with ASD aged 3 to 4 years were compared with chronological age matched typically developing children (TD) and chronologic and mental age matched children with developmental delay (DD). Volumes of the cerebellum and midsagittal vermal areas were measured from 3-D T1-weighted MR images. Children with ASD had reduced total vermis volumes compared to children with TD after controlling for age, sex, and overall cerebral volume or cerebellum volume. In particular, the vermis lobe VI-VII area was reduced in children with ASD compared to TD children. Children with DD had smaller total vermis areas compared to children with ASD and TD. Within the ASD group, cerebellar measurements were not correlated with symptom severity, or verbal, non-verbal or full scale IQ. Within the DD group, larger cerebellar measurements were correlated with less impairments. The specific relation between altered cerebellar structure and symptom expression in autism remains unclear. PMID:19243924

  3. Pore volume is most highly correlated with the visual assessment of skin pores.

    PubMed

    Kim, S J; Shin, M K; Back, J H; Koh, J S

    2014-11-01

    Many studies have been focused on evaluating assessment techniques for facial pores amid growing attention on skin care. Ubiquitous techniques used to assess the size of facial pores include visual assessment, cross-section images of the skin surface, and profilometric analysis of silicone replica of the facial skin. In addition, there are indirect assessment methods, including observation of pores based on confocal laser scanning microscopy and the analysis of sebum secretion and skin elasticity. The aim of this study was to identify parameters useful in estimating pore of surface in normal skin. The severity of pores on the cheek area by frontal optical images was divided on a 0-6 scale with '0' being faint and small pore and '6' being obvious and large pore. After the photos of the frontal cheek of 32 women aged between 35 and 49 were taken, the size of their pores was measured on a 0-6 scale; and the correlation between visual grading of pore and various evaluations (pore volume by 3-D image, pore area and number by Optical Image Analyzer) contributing to pore severity investigated using direct, objective, and noninvasive evaluations. The visual score revealed that the size of pores was graded on a 1-6 scale. Visual grading of pore was highly correlated with pore volume measured from 3-D images and pore area measured from 2-D optical images in the order (P < 0.01). Visual grading of pore was also slightly correlated with the number of pores in size of over 0.04 mm(2) (P < 0.05). High correlation between pore score and pore volume can be explained by 3-D structural characteristics of pores. It is concluded that pore volume and area serve as useful parameters in estimating pore of skin surface. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. Volume localized spin echo correlation spectroscopy with suppression of ‘diagonal' peaks

    NASA Astrophysics Data System (ADS)

    Banerjee, Abhishek; Chandrakumar, N.

    2014-02-01

    Two dimensional homonuclear 1H correlation spectroscopy is of considerable interest for volume localized spectral studies, both in vivo and in vitro, of biological as well as material objects. The information principally sought from correlation spectra resides in the cross-peaks, which are often masked however by the presence of diagonal peaks in COSY, or ‘pseudo-diagonal' peaks at F1 = 0 in SECSY. It has therefore been a concern to suppress these diagonal or ‘pseudo-diagonal' peaks, in order to ensure that cross-peak information is fully discernible. We present here a report of our work on volume localized DIagonal Suppressed Spin Echo Correlation specTroscopy (LDISSECT) and demonstrate its performance in comparison to the standard volume localized SECSY experiment, employing brain metabolite phantoms in a gel. The sequence works in the inhomogeneous, multi-component environment by exploiting the short acquisition time to suppress undesired information by employing an additional rf pulse. A brief description of the pulse sequence, its theory, and simulations are also included, besides experimental benchmarking on two brain metabolite phantoms in gel phase.

  5. Volume localized spin echo correlation spectroscopy with suppression of 'diagonal' peaks.

    PubMed

    Banerjee, Abhishek; Chandrakumar, N

    2014-02-01

    Two dimensional homonuclear (1)H correlation spectroscopy is of considerable interest for volume localized spectral studies, both in vivo and in vitro, of biological as well as material objects. The information principally sought from correlation spectra resides in the cross-peaks, which are often masked however by the presence of diagonal peaks in COSY, or 'pseudo-diagonal' peaks at F1=0 in SECSY. It has therefore been a concern to suppress these diagonal or 'pseudo-diagonal' peaks, in order to ensure that cross-peak information is fully discernible. We present here a report of our work on volume localized DIagonal Suppressed Spin Echo Correlation specTroscopy (LDISSECT) and demonstrate its performance in comparison to the standard volume localized SECSY experiment, employing brain metabolite phantoms in a gel. The sequence works in the inhomogeneous, multi-component environment by exploiting the short acquisition time to suppress undesired information by employing an additional rf pulse. A brief description of the pulse sequence, its theory, and simulations are also included, besides experimental benchmarking on two brain metabolite phantoms in gel phase. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. A flexible and accurate digital volume correlation method applicable to high-resolution volumetric images

    NASA Astrophysics Data System (ADS)

    Pan, Bing; Wang, Bo

    2017-10-01

    Digital volume correlation (DVC) is a powerful technique for quantifying interior deformation within solid opaque materials and biological tissues. In the last two decades, great efforts have been made to improve the accuracy and efficiency of the DVC algorithm. However, there is still a lack of a flexible, robust and accurate version that can be efficiently implemented in personal computers with limited RAM. This paper proposes an advanced DVC method that can realize accurate full-field internal deformation measurement applicable to high-resolution volume images with up to billions of voxels. Specifically, a novel layer-wise reliability-guided displacement tracking strategy combined with dynamic data management is presented to guide the DVC computation from slice to slice. The displacements at specified calculation points in each layer are computed using the advanced 3D inverse-compositional Gauss–Newton algorithm with the complete initial guess of the deformation vector accurately predicted from the computed calculation points. Since only limited slices of interest in the reference and deformed volume images rather than the whole volume images are required, the DVC calculation can thus be efficiently implemented on personal computers. The flexibility, accuracy and efficiency of the presented DVC approach are demonstrated by analyzing computer-simulated and experimentally obtained high-resolution volume images.

  7. Packing hyperspheres in high-dimensional Euclidean spaces.

    PubMed

    Skoge, Monica; Donev, Aleksandar; Stillinger, Frank H; Torquato, Salvatore

    2006-10-01

    We present a study of disordered jammed hard-sphere packings in four-, five-, and six-dimensional Euclidean spaces. Using a collision-driven packing generation algorithm, we obtain the first estimates for the packing fractions of the maximally random jammed (MRJ) states for space dimensions d=4, 5, and 6 to be phi(MRJ) approximately 0.46, 0.31, and 0.20, respectively. To a good approximation, the MRJ density obeys the scaling form phi(MRJ)=c1/2(d)+(c2d)/2d, where c1=-2.72 and c2=2.56, which appears to be consistent with the high-dimensional asymptotic limit, albeit with different coefficients. Calculations of the pair correlation function g2(r) and structure factor S(k) for these states show that short-range ordering appreciably decreases with increasing dimension, consistent with a recently proposed "decorrelation principle," which, among other things, states that unconstrained correlations diminish as the dimension increases and vanish entirely in the limit d-->infinity. As in three dimensions (where phi(MRJ) approximately 0.64), the packings show no signs of crystallization, are isostatic, and have a power-law divergence in g2(r) at contact with power-law exponent approximately 0.4. Across dimensions, the cumulative number of neighbors equals the kissing number of the conjectured densest packing close to where g2(r) has its first minimum. Additionally, we obtain estimates for the freezing and melting packing fractions for the equilibrium hard-sphere fluid-solid transition, phi(F) approximately 0.32 and phi(M) approximately 0.39, respectively, for d=4, and phi(F) approximately 0.20 and phi(M) approximately 0.25, respectively, for d=5. Although our results indicate the stable phase at high density is a crystalline solid, nucleation appears to be strongly suppressed with increasing dimension.

  8. The Correlation Between Prostate Volume in Patients with Benign Prostatic Hyperplasia in Relation to Erectile Dysfunction.

    PubMed

    Kardasevic, Amel; Milicevic, Snjezana

    2016-12-01

    The exact etiology of lower urinary tract symptoms caused by benign prostatic hyperplasia (BPH) has not yet been determined, and the etiology of erectile dysfunction (ED) is often multicausal and includes organic and/or psychogenic causes, as well as their combinations. Although the relation of BPH, and thus the volume of the prostate (VP) with ED is indisputable, precise mechanisms of integration are still under examination. The objective was to evaluate the correlation between prostate volume and degree of erectile dysfunction in patients with symptoms of lower urinary tract caused by benign prostatic hyperplasia. Material and Methods. 150 subjects with BPH, and before starting the BPH treatment, which can affect the sexual function, were divided into three groups: 50 patients with prostate volume of 30 to 40 ml (group A), 50 patients with a volume of 40 to 60 ml (group B) and 50 patients with prostate volume above 60 ml (group C). Quantification of erectile function is performed in all respondents by International Index of Erectile Function with five questions (IIEF-5). The mean IIEF-5 in group A was 20.52 points with a standard deviation of 3.22, in group B 17.08 points with a standard deviation of 4.10, while in group C 10.78 points, with a standard deviation of 3.29. Comparing the results of a statistical analysis from all three groups of patients with the degree of ED, Group A had the highest value of IIEF-5, group C the lowest mean value of IIEF-5. The results of ANOVA (F=96.375, p=0.000) indicated that there was a statistically significant difference (p<0.05) between groups at high values of IIEF-5. Additional analysis by Turkey test revealed that there was a statistically significant difference between the first and second groups (p=0.000 <0.05), the first and third groups (p=0.000 <0.05) and the second and third groups (p=0.000 <0.05). Results of Fisher's exact test (p=0.000) confirmed that there was a statistically significant relationship (p<0

  9. The Correlation Between Prostate Volume in Patients with Benign Prostatic Hyperplasia in Relation to Erectile Dysfunction

    PubMed Central

    Kardasevic, Amel; Milicevic, Snjezana

    2016-01-01

    Introduction: The exact etiology of lower urinary tract symptoms caused by benign prostatic hyperplasia (BPH) has not yet been determined, and the etiology of erectile dysfunction (ED) is often multicausal and includes organic and/or psychogenic causes, as well as their combinations. Although the relation of BPH, and thus the volume of the prostate (VP) with ED is indisputable, precise mechanisms of integration are still under examination. Goal: The objective was to evaluate the correlation between prostate volume and degree of erectile dysfunction in patients with symptoms of lower urinary tract caused by benign prostatic hyperplasia. Material and Methods. 150 subjects with BPH, and before starting the BPH treatment, which can affect the sexual function, were divided into three groups: 50 patients with prostate volume of 30 to 40 ml (group A), 50 patients with a volume of 40 to 60 ml (group B) and 50 patients with prostate volume above 60 ml (group C). Quantification of erectile function is performed in all respondents by International Index of Erectile Function with five questions (IIEF-5). Results: The mean IIEF-5 in group A was 20.52 points with a standard deviation of 3.22, in group B 17.08 points with a standard deviation of 4.10, while in group C 10.78 points, with a standard deviation of 3.29. Comparing the results of a statistical analysis from all three groups of patients with the degree of ED, Group A had the highest value of IIEF-5, group C the lowest mean value of IIEF-5. The results of ANOVA (F=96.375, p=0.000) indicated that there was a statistically significant difference (p<0.05) between groups at high values of IIEF-5. Additional analysis by Turkey test revealed that there was a statistically significant difference between the first and second groups (p=0.000 <0.05), the first and third groups (p=0.000 <0.05) and the second and third groups (p=0.000 <0.05). Results of Fisher’s exact test (p=0.000) confirmed that there was a statistically

  10. Enteral nutrition volume is not correlated with lower respiratory tract infection in patients on mechanical ventilation.

    PubMed

    Colomar, A; Guardiola, B; Llompart-Pou, J A; Ayestarán, I; Rodríguez-Pilar, J; Ferreruela, M; Raurich, J M

    To evaluate the effect of enteral nutrition volume, gastrointestinal function and the type of acid suppressive drug upon the incidence of lower respiratory tract infections in critically ill patients on mechanical ventilation (MV). A retrospective secondary analysis was carried out. The Intensive Care Unit of a University Hospital. Patients≥18-years-old expected to need MV for more than four days, and receiving enteral nutrition by nasogastric tube within 24h of starting MV. We correlated enteral nutrition volume administered during the first 10 days, gastrointestinal function and the type of acid suppressive therapy with the episodes of lower respiratory tract infection up until day 28. Cox proportional hazards ratios in univariate and adjusted multivariate models were used. Statistical significance was considered for p<0.05. Lower respiratory tract infection episodes. Sixty-six out of 185 patients (35.7%) had infection; 27 patients had ventilator-associated pneumonia; and 39 presented ventilator-associated tracheobronchitis. Uninfected and infected groups were similar in terms of enteral nutrition volume (54±12 and 54±9mL/h; p=0.94) and caloric intake (19.4±4.9 and 19.6±5.2kcal/kg/d; p=0.81). The Cox proportional hazards model showed neurological indication of MV to be the only independent variable related to infection (p=0.001). Enteral nutrition volume, the type of acid suppressive therapy, and the use of prokinetic agents were not significantly correlated to infection. Enteral nutrition volume and caloric intake, gastrointestinal dysfunction and the type of acid suppressive therapy used were not associated to lower respiratory tract infection in patients on MV. Copyright © 2016 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

  11. A Euclidean bridge to the relativistic constituent quark model

    NASA Astrophysics Data System (ADS)

    Hobbs, Timothy; Alberg, Mary; Miller, Gerald

    2017-01-01

    We explore the potential of a Euclidean constituent quark model (ECQM) to bridge the lingering gap between Euclidean and Minkowski field theories in studies of nucleon structure. Specifically, we develop our ECQM using a simplified quark-scalar diquark picture of the nucleon as a first calculation. Our treatment in Euclidean space necessitates a hyperspherical formalism involving polynomial expansions of diquark propagators in order to marry our ECQM with results from Bethe-Salpeter Equation (BSE) analyses. From this framework, we define and compute a new quantity - a Euclidean density function (EDF) - an object that characterizes the nucleon's various charge distributions as functions of the quark's Euclidean momentum. Applying this technology and incorporating information from BSE analyses, we find the quenched dressing effect on the proton's axial-singlet charge to be small in magnitude and consistent with zero, while use of recent determinations of unquenched BSEs results in a large suppression. The substantial effect we obtain for the impact on the axial-singlet charge of the unquenched dressed vertex compared to the quenched demands further investigation. Work supported by DOE grant DE-FG02-97ER-41014 and NSF Grant No. 1516105.

  12. Finite volume effects and N-body matter correlations in a CDM simulation

    NASA Astrophysics Data System (ADS)

    Colombi, S.; Bouchet, F. R.

    1992-12-01

    We study, using count probabilities measurements, the consequences of finite sample effects on N-body (2 <= N <= 5) averaged matter correlation functions barξ_N inside cubic volumes for a CDM universe (Efstathiou et al. 1988) with approx 3 10^5 particles generated with a PM code. We try to assess the importance of this effect by applying some correction to the data. The results show that finite effects should be important on N-body correlation functions for N >= 3, and not negligible even on the two-point correlation function. Moreover, once corrected, the statistical properties of this CDM universe appear compatible with the scaling relation (Groth & Peebles 1977; Davis & Peebles 1983; Fry & Peebles 1978; Sharp, Bonometto & Lucchin 1984) barξ_N/barξ_2^{N-1}= constant with respect to scale, over all scales investigated, which was not the case with direct uncorrected measurements.

  13. Improvement to human-face recognition in a volume holographic correlator by use of speckle modulation.

    PubMed

    Cao, Liangcai; He, Qingsheng; Ouyang, Chuan; Liao, Yi; Jin, Guofan

    2005-02-01

    We show that a speckle-modulation technique can improve the parallelism and the recognition accuracy of volume holographic correlators. The object patterns are modulated by a speckle pattern generated by a diffuser. These modulated patterns are stored as Fourier holograms by use of angular-fractal multiplexing. With the speckle modulation the sidelobes are completely suppressed, the cross talk is negligible, and the correlation peak becomes a bright sharp spot. Thus higher recognition accuracy is achieved. The angular separation between adjacent patterns in the multiplexing could be much smaller, resulting in larger capacity and higher parallelism of the correlator. Also, this technique can be combined with other methods such as wavelet filtering to achieve a large invariant tolerance range. Theoretical analysis, numerical evaluation, and experimental results are presented to confirm that sidelobes and cross talk are sharply suppressed by the speckle modulation.

  14. Geochemical correlation of three large-volume ignimbrites from the Yellowstone hotspot track, Idaho, USA

    NASA Astrophysics Data System (ADS)

    Ellis, Ben S.; Branney, M. J.; Barry, T. L.; Barfod, D.; Bindeman, I.; Wolff, J. A.; Bonnichsen, B.

    2012-01-01

    Three voluminous rhyolitic ignimbrites have been identified along the southern margin of the central Snake River Plain. As a result of wide-scale correlations, new volume estimates can be made for these deposits: ~350 km3 for the Steer Basin Tuff and Cougar Point Tuff XI, and ~1,000 km3 for Cougar Point Tuff XIII. These volumes exclude any associated regional ashfalls and correlation across to the north side of the plain, which has yet to be attempted. Each correlation was achieved using a combination of methods including field logging, whole rock and mineral chemistry, magnetic polarity, oxygen isotope signature and high-precision 40Ar/39Ar geochronology. The Steer Basin Tuff, Cougar Point Tuff XI and Cougar Point Tuff XIII have deposit characteristics typical of `Snake River (SR)-type' volcanism: they are very dense, intensely welded and rheomorphic, unusually well sorted with scarce pumice and lithic lapilli. These features differ significantly from those of deposits from the better-known younger eruptions of Yellowstone. The ignimbrites also exhibit marked depletion in δ18O, which is known to characterise the SR-type rhyolites of the central Snake River Plain, and cumulatively represent ~1,700 km3 of low δ18O rhyolitic magma (feldspar values 2.3-2.9‰) erupted within 800,000 years. Our work reduces the total number of ignimbrites recognised in the central Snake River Plain by 6, improves the link with the ashfall record of Yellowstone hotspot volcanism and suggests that more large-volume ignimbrites await discovery through detailed correlation work amidst the vast ignimbrite record of volcanism in this bimodal large igneous province.

  15. CSF tau markers are correlated with hippocampal volume in Alzheimer's disease.

    PubMed

    de Souza, Leonardo C; Chupin, Marie; Lamari, Foudil; Jardel, Claude; Leclercq, Delphine; Colliot, Olivier; Lehéricy, Stéphane; Dubois, Bruno; Sarazin, Marie

    2012-07-01

    Hippocampal atrophy as assessed by magnetic resonance imaging (MRI) and abnormal cerebrospinal fluid (CSF) biomarkers are supportive features for the diagnosis of Alzheimer's disease (AD) and are assumed to be indirect pathological markers of the disease. In AD patients, antemortem MRI hippocampal volumes (HVs) correlate with the density of neurofibrillary tangles (but not with senile plaques) at autopsy suggesting that HVs may better correlate with CSF tau and hyperphosphorylated tau (P-tau) levels than CSF amyloid beta protein (Aβ)(42) level. Here, we tested this hypothesis in a well-defined AD group. Patients were selected according to the New Research Criteria for AD, including specific episodic memory deficit and CSF AD profile (defined as abnormal ratio of Aβ(42):tau). MRI was performed within 6 months of lumbar puncture. HVs were obtained using automated segmentation software. Thirty-six patients were included. Left HV correlated with CSF tau (R = -0.53) and P-tau (R = -0.56) levels. Mean HVs correlated with the CSF P-tau level (R = -0.52). No correlation was found between any brain measurement and CSF Aβ(42) level. The CSF tau and P-tau levels, but not the CSF Aβ(42) level, correlated with HV, suggesting that CSF tau markers reflect the neuronal loss associated with the physiopathological process of AD.

  16. Gray matter alterations and correlation of nutritional intake with the gray matter volume in prediabetes

    PubMed Central

    Hou, Yi-Cheng; Lai, Chien-Han; Wu, Yu-Te; Yang, Shwu-Huey

    2016-01-01

    Abstract The neurophysiology of prediabetes plays an important role in preventive medicine. The dysregulation of glucose metabolism is likely linked to changes in neuron-related gray matter. Therefore, we designed this study to investigate gray matter alterations in medication-naive prediabetic patients. We expected to find alterations in the gray matter of prediabetic patients. A total of 64 prediabetic patients and 54 controls were enrolled. All subjects received T1 scans using a 3-T magnetic resonance imaging machine. Subjects also completed nutritional intake records at the 24-hour and 3-day time points to determine their carbohydrate, protein, fat, and total calorie intake. We utilized optimized voxel-based morphometry to estimate the gray matter differences between the patients and controls. In addition, the preprandial serum glucose level and the carbohydrate, protein, fat, and total calorie intake levels were tested to determine whether these parameters were correlated with the gray matter volume. Prediabetic patients had lower gray matter volumes than controls in the right anterior cingulate gyrus, right posterior cingulate gyrus, left insula, left super temporal gyrus, and left middle temporal gyrus (corrected P < 0.05; voxel threshold: 33). Gray matter volume in the right anterior cingulate was also negatively correlated with the preprandial serum glucose level gyrus in a voxel-dependent manner (r = –0.501; 2-tailed P = 0.001). The cingulo-temporal and insula gray matter alterations may be associated with the glucose dysregulation in prediabetic patients. PMID:27336893

  17. Self-reported impulsivity is negatively correlated with amygdalar volumes in cocaine dependence

    PubMed Central

    Mei, Songli; Xu, Jiansong; Carroll, Kathleen M.; Potenza, Marc N.

    2015-01-01

    Although impulsivity has been associated with cocaine dependence and other addictive behaviors, the biological factors underlying impulsivity have yet to be precisely determined. This study aimed to examine relationships between impulsivity and volumes of the amygdala and hippocampus in cocaine-dependent and healthy comparison individuals. The Barratt Impulsiveness Scale (BIS-11) was used to assess impulsivity. FreeSurfer was used to assess amygdalar and hippocampal volumes from high-resolution structural magnetic resonance images. Relative to healthy comparison subjects, cocaine-dependent individuals scored higher on all three subscales of BIS-11 but did not differ from healthy comparison subjects in amygdalar or hippocampal volumes. Cocaine-dependent individuals showed significant negative correlations between amygdalar volumes and scores on the BIS-11 Attentional subscale, and this relationship differed significantly from the non-significant relationship in healthy comparison subjects. As individual differences in amygdalar structure may contribute to the high impulsivity observed in cocaine-dependent individuals, the findings suggest that future studies should assess the extent to which therapies that target impulsivity in cocaine dependence may operate through the amygdala or alter its structure or function. PMID:26187551

  18. Nondegenerate superintegrable systems in n-dimensional Euclidean spaces

    SciTech Connect

    Kalnins, E. G.; Kress, J. M. Miller, W.; Pogosyan, G. S.

    2007-03-15

    We analyze the concept of a nondegenerate superintegrable system in n-dimensional Euclidean space. Attached to this idea is the notion that every such system affords a separation of variables in one of the various types of generic elliptical coordinates that are possible in complex Euclidean space. An analysis of how these coordinates are arrived at in terms of their expression in terms of Cartesian coordinates is presented in detail. The use of well-defined limiting processes illustrates just how all these systems can be obtained from the most general nondegenerate superintegrable system in n-dimensional Euclidean space. Two examples help with the understanding of how the general results are obtained.

  19. One-loop diagrams in the random Euclidean matching problem

    NASA Astrophysics Data System (ADS)

    Lucibello, Carlo; Parisi, Giorgio; Sicuro, Gabriele

    2017-01-01

    The matching problem is a notorious combinatorial optimization problem that has attracted for many years the attention of the statistical physics community. Here we analyze the Euclidean version of the problem, i.e., the optimal matching problem between points randomly distributed on a d -dimensional Euclidean space, where the cost to minimize depends on the points' pairwise distances. Using Mayer's cluster expansion we write a formal expression for the replicated action that is suitable for a saddle point computation. We give the diagrammatic rules for each term of the expansion, and we analyze in detail the one-loop diagrams. A characteristic feature of the theory, when diagrams are perturbatively computed around the mean field part of the action, is the vanishing of the mass at zero momentum. In the non-Euclidean case of uncorrelated costs instead, we predict and numerically verify an anomalous scaling for the sub-sub-leading correction to the asymptotic average cost.

  20. Discontinuous automorphisms of the proper Galilei and Euclidean groups

    SciTech Connect

    Adeleke, S.A. )

    1989-04-01

    The author shows that there are numerous discontinuous automorphisms of the three-dimensional Euclidean group and thus of the Galilei group, as numerous as the subsets of the real numbers, 2{sup aleph-null}, to be exact. These automorphisms arise from the derivations of the field of real numbers. Tits gave an example of a discontinuous automorphism for the semidirect product of the general linear group GL{sub n}(K) in n dimensions with the additive group of n {times} n matrices. He observes that if one uses the quaternion representation of the rotations and the form of Tits example, one obtains discontinuous automorphisms of the Euclidean group in three dimensions. He shows that all automorphisms of the Euclidean group in higher dimensions are continuous.

  1. Incorporation of excluded-volume correlations into Poisson-Boltzmann theory.

    PubMed

    Antypov, Dmytro; Barbosa, Marcia C; Holm, Christian

    2005-06-01

    We investigate the effect of excluded-volume interactions on the electrolyte distribution around a charged macroion. First, we introduce a criterion for determining when hard-core effects should be taken into account beyond standard mean-field Poisson-Boltzmann (PB) theory. Next, we demonstrate that several commonly proposed local-density-functional approaches for excluded-volume interactions cannot be used for this purpose. Instead, we employ a nonlocal excess free energy by using a simple constant-weight approach. We compare the ion distribution and osmotic pressure predicted by this theory with Monte Carlo simulations. They agree very well for weakly developed correlations and give the correct layering effect for stronger ones. In all investigated cases our simple weighted-density theory yields more realistic results than the standard PB approach, whereas all local density theories do not improve on the PB density profiles, but on the contrary, deviate even more from the simulation results.

  2. Correlation of neurocognitive function and brain parenchyma volumes in children surviving cancer

    NASA Astrophysics Data System (ADS)

    Reddick, Wilburn E.; White, Holly A.; Glass, John O.; Mulhern, Raymond K.

    2002-04-01

    This research builds on our hypothesis that white matter damage and associated neurocognitive symptoms, in children treated for cancer with cranial spinal irradiation, spans a continuum of severity that can be reliably probed using non-invasive MR technology. Quantitative volumetric assessments of MR imaging and psychological assessments were obtained in 40 long-term survivors of malignant brain tumors treated with cranial irradiation. Neurocognitive assessments included a test of intellect (Wechsler Intelligence Test for Children, Wechsler Adult Intelligence Scale), attention (Conner's Continuous Performance Test), and memory (California Verbal Learning Test). One-sample t-tests were conducted to evaluate test performance of survivors against age-adjusted scores from the test norms; these analyses revealed significant impairments in all apriori selected measures of intelligence, attention, and memory. Partial correlation analyses were performed to assess the relationships between brain tissues volumes (normal appearing white matter (NAWM), gray matter, and CSF) and neurocognitive function. Global intelligence (r = 0.32, p = 0.05) and global attentional (r = 0.49, p < 0.01) were significantly positively correlated with NAWM volumes, whereas global memory was significantly positively correlated with overall brain parenchyma (r = 0.38, p = 0.04). We conclude that quantitative assessment of MR examinations in survivors of childhood cancer treated with cranial irradiation reveal that loss of NAWM is associated with decreased intellectual and attentional deficits, whereas overall parenchyma loss, as reflected by increased CSF and decreased white matter, is associated with memory-related deficits.

  3. Modeling of Euclidean braided fiber architectures to optimize composite properties

    NASA Technical Reports Server (NTRS)

    Armstrong-Carroll, E.; Pastore, C.; Ko, F. K.

    1992-01-01

    Three-dimensional braided fiber reinforcements are a very effective toughening mechanism for composite materials. The integral yarn path inherent to this fiber architecture allows for effective multidirectional dispersion of strain energy and negates delamination problems. In this paper a geometric model of Euclidean braid fiber architectures is presented. This information is used to determine the degree of geometric isotropy in the braids. This information, when combined with candidate material properties, can be used to quickly generate an estimate of the available load-carrying capacity of Euclidean braids at any arbitrary angle.

  4. Intracranial pressure pulse waveform correlates with aqueductal cerebrospinal fluid stroke volume.

    PubMed

    Hamilton, Robert; Baldwin, Kevin; Fuller, Jennifer; Vespa, Paul; Hu, Xiao; Bergsneider, Marvin

    2012-11-01

    This study identifies a novel relationship between cerebrospinal fluid (CSF) stroke volume through the cerebral aqueduct and the characteristic peaks of the intracranial pulse (ICP) waveform. ICP waveform analysis has become much more advanced in recent years; however, clinical practice remains restricted to mean ICP, mainly due to the lack of physiological understanding of the ICP waveform. Therefore, the present study set out to shed some light on the physiological meaning of ICP morphological metrics derived by the morphological clustering and analysis of continuous intracranial pulse (MOCAIP) algorithm by investigating their relationships with a well defined physiological variable, i.e., the stroke volume of CSF through the cerebral aqueduct. Seven patients received both overnight ICP monitoring along with a phase-contrast MRI (PC-MRI) of the cerebral aqueduct to quantify aqueductal stroke volume (ASV). Waveform morphological analysis of the ICP signal was performed by the MOCAIP algorithm. Following extraction of morphological metrics from the ICP signal, nine temporal ICP metrics and two amplitude-based metrics were compared with the ASV via Spearman's rank correlation. Of the nine temporal metrics correlated with the ASV, only the width of the P2 region (ICP-Wi2) reached significance. Furthermore, both ICP pulse pressure amplitude and mean ICP did not reach significance. In this study, we showed the width of the second peak (ICP-Wi2) of an ICP pulse wave is positively related to the volume of CSF movement through the cerebral aqueduct. This finding is an initial step in bridging the gap between ICP waveform morphology research and clinical practice.

  5. Correlation between loss of renal function and loss of renal volume after partial nephrectomy for tumor in a solitary kidney.

    PubMed

    Sharma, Nidhi; O'Hara, Jerome; Novick, Andrew C; Lieber, Michael; Remer, Erick M; Herts, Brian R

    2008-04-01

    We assessed the correlation between reduced renal function and parenchymal volume following partial nephrectomy. In 21 of 42 patients with tumors in a solitary kidney who were enrolled in a study measuring function before and after surgery underwent computerized tomography, and measurement of the glomerular filtration rate and estimated glomerular filtration rate (the latter at baseline and 2 to 6 months) before and after surgery. A segmentation algorithm was used to measure renal parenchymal volume. The percent of renal parenchymal volume loss was correlated with the percent loss in glomerular filtration rate using the Pearson correlation coefficient. Mean +/- SD net preoperative volume was 284 +/- 67 cc (range 179 to 413) and mean net postoperative volume was 240 +/- 61 cc (range 119 to 346) with an absolute functional volume loss of between 5 and 160 cc. The average percent of parenchymal volume loss was 15% (range -2% to 47%). The mean loss of the measured glomerular filtration rate 3 days postoperatively was 33.9% (range -70.7% to 74.4%) and the estimated glomerular filtration rate 2 to 6 months postoperatively was 19.7 % (-6.0% to 45.5%). There was a low degree of correlation between the percent volume loss and the percent measured glomerular filtration rate loss at 3 days (r = 0.28, p = 0.22). However, there was a moderate degree of correlation between the percent volume loss and the percent estimated glomerular filtration rate loss at 2 to 6 months (r = 0.48, p = 0.03). In patients with partial nephrectomy the renal parenchymal volume loss correlates best with the renal function loss several months after surgery. Estimates of volume loss may be useful for predicting postoperative renal function when planning partial nephrectomy in patients with a solitary kidney.

  6. Fluctuations and correlations of conserved charges in an excluded-volume hadron resonance gas model

    NASA Astrophysics Data System (ADS)

    Bhattacharyya, Abhijit; Das, Supriya; Ghosh, Sanjay K.; Ray, Rajarshi; Samanta, Subhasis

    2014-09-01

    We present temperature and baryonic chemical potential dependence of higher-order fluctuations and the correlation between conserved charges in an excluded-volume hadron resonance gas model. Products of moments, such as the ratio of variance to mean, product of skewness and standard deviation, product of kurtosis and variance, for the net proton, net kaon, and net charge have been evaluated on the phenomenologically determined freeze-out curve. Further, products of moments for net proton and net charge have been compared with the experimental data measured by the STAR experiment. The dependence of the model result on the hadronic radius parameter has also been discussed.

  7. Rotation invariant pattern recognition with a volume holographic wavelet correlation processor

    NASA Astrophysics Data System (ADS)

    Tan, Wenzhao; Xue, Qingzeng; Yan, Yingbai; Jin, Guofan

    2003-02-01

    A volume holographic wavelet correlation processor for performing rotation invariant pattern recognition is suggested. It uses wavelet transform to get the digital edge extraction of the original object and a single circular harmonic component is used as the matched filter to get good rotation invariance. The new filter used in this method is called wavelet circular harmonic component filter (WCHCF). Simulation results validate the theory and the experiment to recognize human faces with any rotation angle shows the utility of the newly proposed method.

  8. Long memory of abnormal investor attention and the cross-correlations between abnormal investor attention and trading volume, volatility respectively

    NASA Astrophysics Data System (ADS)

    Fan, Xiaoqian; Yuan, Ying; Zhuang, Xintian; Jin, Xiu

    2017-03-01

    Taking Baidu Index as a proxy for abnormal investor attention (AIA), the long memory property in the AIA of Shanghai Stock Exchange (SSE) 50 Index component stocks was empirically investigated using detrended fluctuation analysis (DFA) method. The results show that abnormal investor attention is power-law correlated with Hurst exponents between 0.64 and 0.98. Furthermore, the cross-correlations between abnormal investor attention and trading volume, volatility respectively are studied using detrended cross-correlation analysis (DCCA) and the DCCA cross-correlation coefficient (ρDCCA). The results suggest that there are positive correlations between AIA and trading volume, volatility respectively. In addition, the correlations for trading volume are in general higher than the ones for volatility. By carrying on rescaled range analysis (R/S) and rolling windows analysis, we find that the results mentioned above are effective and significant.

  9. Serotonergic, brain volume and attentional correlates of trait anxiety in primates.

    PubMed

    Mikheenko, Yevheniia; Shiba, Yoshiro; Sawiak, Stephen; Braesicke, Katrin; Cockcroft, Gemma; Clarke, Hannah; Roberts, Angela C

    2015-05-01

    Trait anxiety is a risk factor for the development and maintenance of affective disorders, and insights into the underlying brain mechanisms are vital for improving treatment and prevention strategies. Translational studies in non-human primates, where targeted neurochemical and genetic manipulations can be made, are critical in view of their close neuroanatomical similarity to humans in brain regions implicated in trait anxiety. Thus, we characterised the serotonergic and regional brain volume correlates of trait-like anxiety in the marmoset monkey. Low- and high-anxious animals were identified by behavioral responses to a human intruder (HI) that are known to be sensitive to anxiolytic drug treatment. Extracellular serotonin levels within the amygdala were measured with in vivo microdialysis, at baseline and in response to challenge with the selective serotonin reuptake inhibitor, citalopram. Regional brain volume was assessed by structural magnetic resonance imaging. Anxious individuals showed persistent, long-term fearful responses to both a HI and a model snake, alongside sustained attention (vigilance) to novel cues in a context associated with unpredictable threat. Neurally, high-anxious marmosets showed reduced amygdala serotonin levels, and smaller volumes in a closely connected prefrontal region, the dorsal anterior cingulate cortex. These findings highlight behavioral and neural similarities between trait-like anxiety in marmosets and humans, and set the stage for further investigation of the processes contributing to vulnerability and resilience to affective disorders.

  10. Serotonergic, Brain Volume and Attentional Correlates of Trait Anxiety in Primates

    PubMed Central

    Mikheenko, Yevheniia; Shiba, Yoshiro; Sawiak, Stephen; Braesicke, Katrin; Cockcroft, Gemma; Clarke, Hannah; Roberts, Angela C

    2015-01-01

    Trait anxiety is a risk factor for the development and maintenance of affective disorders, and insights into the underlying brain mechanisms are vital for improving treatment and prevention strategies. Translational studies in non-human primates, where targeted neurochemical and genetic manipulations can be made, are critical in view of their close neuroanatomical similarity to humans in brain regions implicated in trait anxiety. Thus, we characterised the serotonergic and regional brain volume correlates of trait-like anxiety in the marmoset monkey. Low- and high-anxious animals were identified by behavioral responses to a human intruder (HI) that are known to be sensitive to anxiolytic drug treatment. Extracellular serotonin levels within the amygdala were measured with in vivo microdialysis, at baseline and in response to challenge with the selective serotonin reuptake inhibitor, citalopram. Regional brain volume was assessed by structural magnetic resonance imaging. Anxious individuals showed persistent, long-term fearful responses to both a HI and a model snake, alongside sustained attention (vigilance) to novel cues in a context associated with unpredictable threat. Neurally, high-anxious marmosets showed reduced amygdala serotonin levels, and smaller volumes in a closely connected prefrontal region, the dorsal anterior cingulate cortex. These findings highlight behavioral and neural similarities between trait-like anxiety in marmosets and humans, and set the stage for further investigation of the processes contributing to vulnerability and resilience to affective disorders. PMID:25586542

  11. GSTM1 gene expression correlates to leiomyoma volume regression in response to mifepristone treatment.

    PubMed

    Engman, Mikael; Varghese, Suby; Lagerstedt Robinson, Kristina; Malmgren, Helena; Hammarsjö, Anna; Byström, Birgitta; Lalitkumar, Parameswaran Grace L; Gemzell-Danielsson, Kristina

    2013-01-01

    Progesterone receptor modulators, such as mifepristone are useful and well tolerated in reducing leiomyoma volume although with large individual variation. The objective of this study was to investigate the molecular basis for the observed leiomyoma volume reduction, in response to mifepristone treatment and explore a possible molecular marker for the selective usage of mifepristone in leiomyoma patients. Premenopausal women (N = 14) were treated with mifepristone 50 mg, every other day for 12 weeks prior to surgery. Women were arbitrarily sub-grouped as good (N = 4), poor (N = 4) responders to treatment or intermediate respondents (N = 3). Total RNA was extracted from leiomyoma tissue, after surgical removal of the tumour and the differential expression of genes were analysed by microarray. The results were analysed using Ingenuity Pathway Analysis software. The glutathione pathway was the most significantly altered canonical pathway in which the glutathione-s transferase mu 1 (GSTM1) gene was significantly over expressed (+8.03 folds) among the good responders compared to non responders. This was further confirmed by Real time PCR (p = 0.024). Correlation of immunoreactive scores (IRS) for GSTM1 accumulation in leiomyoma tissue was seen with base line volume change of leiomyoma R = -0.8 (p = 0.011). Furthermore the accumulation of protein GSTM1 analysed by Western Blot correlated significantly with the percentual leiomyoma volume change R = -0.82 (p = 0.004). Deletion of the GSTM1 gene in leiomyoma biopsies was found in 50% of the mifepristone treated cases, with lower presence of the GSTM1 protein. The findings support a significant role for GSTM1 in leiomyoma volume reduction induced by mifepristone and explain the observed individual variation in this response. Furthermore the finding could be useful to further explore GSTM1 as a biomarker for tailoring medical treatment of uterine leiomyomas for optimizing the response to

  12. GSTM1 Gene Expression Correlates to Leiomyoma Volume Regression in Response to Mifepristone Treatment

    PubMed Central

    Engman, Mikael; Varghese, Suby; Lagerstedt Robinson, Kristina; Malmgren, Helena; Hammarsjö, Anna; Byström, Birgitta; L Lalitkumar, Parameswaran Grace; Gemzell-Danielsson, Kristina

    2013-01-01

    Progesterone receptor modulators, such as mifepristone are useful and well tolerated in reducing leiomyoma volume although with large individual variation. The objective of this study was to investigate the molecular basis for the observed leiomyoma volume reduction, in response to mifepristone treatment and explore a possible molecular marker for the selective usage of mifepristone in leiomyoma patients. Premenopausal women (N = 14) were treated with mifepristone 50 mg, every other day for 12 weeks prior to surgery. Women were arbitrarily sub-grouped as good (N = 4), poor (N = 4) responders to treatment or intermediate respondents (N = 3). Total RNA was extracted from leiomyoma tissue, after surgical removal of the tumour and the differential expression of genes were analysed by microarray. The results were analysed using Ingenuity Pathway Analysis software. The glutathione pathway was the most significantly altered canonical pathway in which the glutathione-s transferase mu 1 (GSTM1) gene was significantly over expressed (+8.03 folds) among the good responders compared to non responders. This was further confirmed by Real time PCR (p = 0.024). Correlation of immunoreactive scores (IRS) for GSTM1 accumulation in leiomyoma tissue was seen with base line volume change of leiomyoma R = −0.8 (p = 0.011). Furthermore the accumulation of protein GSTM1 analysed by Western Blot correlated significantly with the percentual leiomyoma volume change R = −0.82 (p = 0.004). Deletion of the GSTM1 gene in leiomyoma biopsies was found in 50% of the mifepristone treated cases, with lower presence of the GSTM1 protein. The findings support a significant role for GSTM1 in leiomyoma volume reduction induced by mifepristone and explain the observed individual variation in this response. Furthermore the finding could be useful to further explore GSTM1 as a biomarker for tailoring medical treatment of uterine leiomyomas for optimizing the response

  13. On the Nonnegative Rank of Euclidean Distance Matrices

    PubMed Central

    Lin, Matthew M.

    2013-01-01

    The Euclidean distance matrix for n distinct points in ℝr is generically of rank r + 2. It is shown in this paper via a geometric argument that its nonnegative rank for the case r = 1 is generically n. PMID:23966751

  14. Peripatetic and Euclidean theories of the visual ray.

    PubMed

    Jones, A

    1994-01-01

    The visual ray of Euclid's Optica is endowed with properties that reveal the concept to be an abstraction of a specific physical account of vision. The evolution of a physical theory of vision compatible with the Euclidean model can be traced in Peripatetic writings of the late fourth and third centuries B.C.

  15. The Role of Structure in Learning Non-Euclidean Geometry

    ERIC Educational Resources Information Center

    Asmuth, Jennifer A.

    2009-01-01

    How do people learn novel mathematical information that contradicts prior knowledge? The focus of this thesis is the role of structure in the acquisition of knowledge about hyperbolic geometry, a non-Euclidean geometry. In a series of three experiments, I contrast a more holistic structure--training based on closed figures--with a mathematically…

  16. From geometry to algebra: the Euclidean way with technology

    NASA Astrophysics Data System (ADS)

    Ferrarello, Daniela; Flavia Mammana, Maria; Pennisi, Mario

    2016-05-01

    In this paper, we present the results of an experimental classroom activity, history-based with a phylogenetic approach, to achieve algebra properties through geometry. In particular, we used Euclidean propositions, processed them by a dynamic geometry system and translate them into algebraic special products.

  17. The Role of Structure in Learning Non-Euclidean Geometry

    ERIC Educational Resources Information Center

    Asmuth, Jennifer A.

    2009-01-01

    How do people learn novel mathematical information that contradicts prior knowledge? The focus of this thesis is the role of structure in the acquisition of knowledge about hyperbolic geometry, a non-Euclidean geometry. In a series of three experiments, I contrast a more holistic structure--training based on closed figures--with a mathematically…

  18. Vectorial moments of curves in Euclidean 3-space

    NASA Astrophysics Data System (ADS)

    Tunçer, Yılmaz

    In this study, we introduced the vectorial moments as a new curves as w-dual curve, where w ∈{T(s),N(s),B(s)}, constructed by the Frenet vectors of a regular curve in Euclidean 3-space and we gave the Frenet apparatus of w-dual curves and also we applied to helices and curve pairs of constant breadth.

  19. A novel CT volume index score correlates with outcomes in polytrauma patients with pulmonary contusion.

    PubMed

    Strumwasser, Aaron; Chu, Eveline; Yeung, Louise; Miraflor, Emily; Sadjadi, Javid; Victorino, Gregory P

    2011-10-01

    Exact quantification of pulmonary contusion by computed tomography (CT) may help trauma surgeons identify high-risk populations. We hypothesized that the size of pulmonary contusions, measured accurately, will predict outcomes. Our specific aims were to (1) precisely quantify pulmonary contusion size using pixel analysis, (2) correlate contusion size with outcomes, and (3) determine the threshold contusion size portending complications. Thoracic CTs of 106 consecutive polytrauma patients with pulmonary contusion were evaluated at a university-based urban trauma center. A novel CT volume index (CTVI) score was calculated based on the ratio of affected lung to total lung [slices of lung on CT × affected pixel region/lung pixel region × 0.45 (left side) + slices of lung on CT × affected pixel region/lung pixel region × 0.55 (right side)]. Multivariate analysis correlated CTVI and patient predictors' impact on outcomes. Of 106 polytrauma patients (mean ISS = 28 ± 1.2, AIS chest = 3.5 ± 0.1), 39 developed complications (acute respiratory distress syndrome [ARDS], pneumonia, and/or death). Mean CTVI was significantly higher in the group with complications (0.28 ± 0.03 versus 17 ± 0.02, P = 0.01). By multivariate analysis, CTVI predicted longer ICU LOS (R(2) = 0.84, P < 0.01). A receiver operating curve (ROC) analysis identified a CTVI threshold score of 0.2 (AUC 0.67, P < 0.01) for developing pneumonia, ARDS or death. Patients with CTVI scores of 0.2 or more had longer hospitalization, longer ICU LOS, more ventilator days, and developed pneumonia (P < 0.01). Higher CTVI scores predicted prolonged ICU LOS across all sizes of pulmonary contusion. Pulmonary contusion volumes greater than 20% of total lung volume specifically identifies patients at risk for developing complications. Copyright © 2011 Elsevier Inc. All rights reserved.

  20. Gray matter volume and executive functioning correlate with time since injury following mild traumatic brain injury.

    PubMed

    Killgore, William D S; Singh, Prabhjyot; Kipman, Maia; Pisner, Derek; Fridman, Andrew; Weber, Mareen

    2016-01-26

    Most people who sustain a mild traumatic brain injury (mTBI) will recover to baseline functioning within a period of several days to weeks. A substantial minority of patients, however, will show persistent symptoms and mild cognitive complaints for much longer. To more clearly delineate how the duration of time since injury (TSI) is associated with neuroplastic cortical volume changes and cognitive recovery, we employed voxel-based morphometry (VBM) and select neuropsychological measures in a cross-sectional sample of 26 patients with mTBI assessed at either two-weeks, one-month, three-months, six-months, or one-year post injury, and a sample of 12 healthy controls. Longer duration of TSI was associated with larger gray matter volume (GMV) within the ventromedial prefrontal cortex (vmPFC) and right fusiform gyrus, and better neurocognitive performance on measures of visuospatial design fluency and emotional functioning. In particular, volume within the vmPFC was positively correlated with design fluency and negatively correlated with symptoms of anxiety, whereas GMV of the fusiform gyrus was associated with greater design fluency and sustained visual psychomotor vigilance performance. Moreover, the larger GMV seen among the more chronic individuals was significantly greater than healthy controls, suggesting possible enlargement of these regions with time since injury. These findings are interpreted in light of burgeoning evidence suggesting that cortical regions often exhibit structural changes following experience or practice, and suggest that with greater time since an mTBI, the brain displays compensatory remodeling of cortical regions involved in emotional regulation, which may reduce distractibility during attention demanding visuo-motor tasks. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  1. Structural and volume changes and their correlation in electron irradiated alkali silicate glasses

    NASA Astrophysics Data System (ADS)

    Gavenda, Tadeáš; Gedeon, Ondrej; Jurek, Karel

    2017-04-01

    Two binary alkali silicate glasses (15K2O·85SiO2 - denoted as K15 and 15Li2O·85SiO2 - denoted as Li15) were irradiated by 50 keV electron beams with doses within the range of 2.1-15.9 kC/m2. Volume changes induced by electron irradiation were monitored by means of Atomic Force Microscopy (AFM). Raman spectra were taken from the irradiated spots to observe structural changes. Volume compaction observed at lower doses was correlated with the increase of the D2 peak. Volume expansion at higher doses was related to migration of alkali ions. Irradiated glasses were annealed at 400 °C and 500 °C for 60 min. After annealing irradiated spots were again examined by AFM and Raman spectroscopy in order to determine volume and structural relaxation of radiation induced changes. Annealing at higher temperatures resulted in the levelling of the pits created by irradiation, but only for doses below incubation dose. The pits created by doses above incubation dose were not levelled. Annealing caused decrease of D2 peak and shift of the Si-O-Si vibrations band in direction to original structure. Low-frequency region of annealed Li15 glass was undistinguishable from that of pristine glass, while annealing of K15 glass did not result in the full reversion to the original shape. The differences between glasses were attributed to higher Tg of K15 glass. Q-motives bands of both glasses were not completely restored after annealing due to the absence of alkali ions.

  2. Euclidean bridge to the relativistic constituent quark model

    NASA Astrophysics Data System (ADS)

    Hobbs, T. J.; Alberg, Mary; Miller, Gerald A.

    2017-03-01

    Background: Knowledge of nucleon structure is today ever more of a precision science, with heightened theoretical and experimental activity expected in coming years. At the same time, a persistent gap lingers between theoretical approaches grounded in Euclidean methods (e.g., lattice QCD, Dyson-Schwinger equations [DSEs]) as opposed to traditional Minkowski field theories (such as light-front constituent quark models). Purpose: Seeking to bridge these complementary world views, we explore the potential of a Euclidean constituent quark model (ECQM). This formalism enables us to study the gluonic dressing of the quark-level axial-vector vertex, which we undertake as a test of the framework. Method: To access its indispensable elements with a minimum of inessential detail, we develop our ECQM using the simplified quark + scalar diquark picture of the nucleon. We construct a hyperspherical formalism involving polynomial expansions of diquark propagators to marry our ECQM with the results of Bethe-Salpeter equation (BSE) analyses, and constrain model parameters by fitting electromagnetic form factor data. Results: From this formalism, we define and compute a new quantity—the Euclidean density function (EDF)—an object that characterizes the nucleon's various charge distributions as functions of the quark's Euclidean momentum. Applying this technology and incorporating information from BSE analyses, we find the quenched dressing effect on the proton's axial-singlet charge to be small in magnitude and consistent with zero, while use of recent determinations of unquenched BSEs results in a large suppression. Conclusions: The quark + scalar diquark ECQM is a step toward a realistic quark model in Euclidean space, and needs additional refinements. The substantial effect we obtain for the impact on the axial-singlet charge of the unquenched dressed vertex compared to the quenched demands further investigation.

  3. Euclidean quantum field theory: Curved spacetimes and gauge fields

    NASA Astrophysics Data System (ADS)

    Ritter, William Gordon

    This thesis presents a new formulation of quantum field theory (QFT) on curved spacetimes, with definite advantages over previous formulations, and an introduction to the millennium prize problem on four-dimensional gauge theory. Our constructions are completely rigorous, making QFT on curved spacetimes into a subfield of mathematics, and we achieve the first analytic control over nonperturbative aspects of interacting theories on curved spacetimes. The success of Euclidean path integrals to capture nonperturbative aspects of QFT has been striking. The Euclidean path integral is the most accurate method of calculating strong-coupling effects in gauge theory (such as glueball masses). Euclidean methods are also useful in the study of black holes, as evidenced by the Hartle-Hawking calculation of black-hole radiance. From a mathematical point of view, on flat spacetimes the Euclidean functional integral provides the most elegant method of constructing examples of interacting relativistic field theories. Yet until now, the incredibly-useful Euclidean path integral had never been given a definitive mathematical treatment on curved backgrounds. It is our aim to rectify this situation. Along the way, we discover that the Dirac operator on an arbitrary Clifford bundle has a resolvent kernel which is the Laplace transform of a positive measure. In studying spacetime symmetries, we discover a new way of constructing unitary representations of noncompact Lie groups. We also define and explore an interesting notion of convergence for Laplacians. The same mathematical framework applies to scalar fields, fermions, and gauge fields. The later chapters are devoted to gauge theory. We present a rigorous, self-contained introduction to the subject, aimed at mathematicians and using the language of modern mathematics, with a view towards nonperturbative renormalization in four dimensions. The latter ideas are unfinished. A completion of the final chapter would imply the construction

  4. Grey matter volume correlates with virtual water maze task performance in boys with androgen excess

    PubMed Central

    Mueller, Sven C.; Merke, Deborah P.; Leschek, Ellen W.; Fromm, Stephen; Grillon, Christian; Cornwell, Brian R.; VanRyzin, Carol; Ernst, Monique

    2011-01-01

    Major questions remain about the specific role of testosterone in human spatial navigation. We tested 10 boys (mean age 11.65 years) with an extremely rare disorder of androgen excess (Familial Male Precocious Puberty, FMPP) and 40 healthy boys (mean age 12.81 years) on a virtual version of the Morris Water Maze task. In addition, anatomical magnetic resonance images were collected for all patients and a subsample of the controls (n=21) after task completion. Behaviourally, no significant differences were found between both groups. However, in the MRI analyses, grey matter volume (GMV) was correlated with performance using voxel-based morphometry (VBM). Group differences in correlations of performance with GMV were apparent in medial regions of the prefrontal cortex as well as the middle occipital gyrus and the cuneus. By comparison, similar correlations for both groups were found in the inferior parietal lobule. These data provide novel insight into the relation between testosterone and brain development and suggest that morphological differences in a spatial navigation network covary with performance in spatial ability. PMID:21964472

  5. Infarct volume on apparent diffusion coefficient maps correlates with length of stay and outcome after middle cerebral artery stroke.

    PubMed

    Engelter, Stefan T; Provenzale, James M; Petrella, Jeffrey R; DeLong, David M; Alberts, Mark J

    2003-01-01

    Diffusion-weighted MRI (DWI) can depict acute ischemia based on decreased apparent diffusion coefficient (ADC) values. ADC maps, unlike DWI (which have contributions from T2 properties), solely reflect diffusion properties. Recent studies indicate that severity of neurological deficit corresponds with degree of ADC alteration. To determine whether infarct volume on ADC maps correlates with length of hospitalization and clinical outcome in patients with acute ischemic middle cerebral artery (MCA) stroke. Forty-five consecutive patients with acute (volume was determined by counting pixels with ADC values >3 SDs below the average ADC value of a contralateral control region. Infarct volume was correlated with length of hospitalization and 6-month outcome assessed with Glasgow Outcome Scale (GOS), Modified Rankin Score (mRS), Barthel Index (BI) and a dichotomized outcome status with favorable outcome defined as GOS 1, mRS or=95. Infarct volume on ADC maps ranged from 0.2 to 187 cm(3) and was significantly correlated with length of hospitalization (p < 0.001, r = 0.67). Furthermore, ADC infarct volume was significantly correlated with GOS (r = 0.73), mRS (r = 0.68), BI (r = 0.67) and outcome status (r = 0.65) (each p < 0.001). Multiple logistic regression revealed a statistically significant correlation between ADC infarct volume and outcome status (p < 0.05), but none for Canadian Neurological Scale score, age and gender (p >0.05 each). Infarct volume measured by using a quantitative definition for infarcted tissue on ADC maps correlated significantly with length of hospitalization (as a possible surrogate marker for short-term outcome) and functional outcome after 6 months. ADC infarct volume may provide prognostic information for patients with acute ischemic MCA stroke. Copyright 2003 S. Karger AG, Basel

  6. Dynamic volume vs respiratory correlated 4DCT for motion assessment in radiation therapy simulation

    SciTech Connect

    Coolens, Catherine; Bracken, John; Driscoll, Brandon; Hope, Andrew; Jaffray, David

    2012-05-15

    Purpose: Conventional (i.e., respiratory-correlated) 4DCT exploits the repetitive nature of breathing to provide an estimate of motion; however, it has limitations due to binning artifacts and irregular breathing in actual patient breathing patterns. The aim of this work was to evaluate the accuracy and image quality of a dynamic volume, CT approach (4D{sub vol}) using a 320-slice CT scanner to minimize these limitations, wherein entire image volumes are acquired dynamically without couch movement. This will be compared to the conventional respiratory-correlated 4DCT approach (RCCT). Methods: 4D{sub vol} CT was performed and characterized on an in-house, programmable respiratory motion phantom containing multiple geometric and morphological ''tumor'' objects over a range of regular and irregular patient breathing traces obtained from 3D fluoroscopy and compared to RCCT. The accuracy of volumetric capture and breathing displacement were evaluated and compared with the ground truth values and with the results reported using RCCT. A motion model was investigated to validate the number of motion samples needed to obtain accurate motion probability density functions (PDF). The impact of 4D image quality on this accuracy was then investigated. Dose measurements using volumetric and conventional scan techniques were also performed and compared. Results: Both conventional and dynamic volume 4DCT methods were capable of estimating the programmed displacement of sinusoidal motion, but patient breathing is known to not be regular, and obvious differences were seen for realistic, irregular motion. The mean RCCT amplitude error averaged at 4 mm (max. 7.8 mm) whereas the 4D{sub vol} CT error stayed below 0.5 mm. Similarly, the average absolute volume error was lower with 4D{sub vol} CT. Under irregular breathing, the 4D{sub vol} CT method provides a close description of the motion PDF (cross-correlation 0.99) and is able to track each object, whereas the RCCT method results in a

  7. Correlation between mass and volume of collected blood with positivity of blood cultures.

    PubMed

    Neves, Lariessa; Marra, Alexandre Rodrigues; Camargo, Thiago Zinsly Sampaio; dos Santos, Maura Cristina; Zulin, Flávia; da Silva, Patrícia Candido; de Moura, Natália Ariede; Victor, Elivane da Silva; Pasternak, Jacyr; dos Santos, Oscar Fernando Pavão; Edmond, Michael B; Martino, Marines Dalla Valle

    2015-08-28

    The collection of blood cultures is an extremely important method in the management of patients with suspected infection. Microbiology laboratories should monitor blood culture collection. Over an 8-month period we developed a prospective, observational study in an adult Intensive Care Unit (ICU). We correlated the mass contained in the blood vials with blood culture positivity and we also verified the relationship between the mass of blood and blood volume collected for the diagnosis of bloodstream infection (BSI), as well as we explored factors predicting positive blood cultures. We evaluated 345 patients with sepsis, severe sepsis or septic shock for whom blood culture bottles were collected for the diagnosis of BSI. Of the 55 patients with BSI, 40.0% had peripheral blood culture collection only. BSIs were classified as nosocomial in 34.5%. In the multivariate model, the blood culture mass (in grams) remained a significant predictor of positivity, with an odds ratio 1.01 (i.e., for each additional 1 mL of blood collected there was a 1% increase in positivity; 95% CI 1.01-1.02, p = 0.001; Nagelkerke R Square [R(2)] = 0.192). For blood volume collected, the adjusted odds ratio was estimated at 1.02 (95% CI: 1.01-1.03, p < 0.001; R(2) = 0.199). For each set of collected blood cultures beyond one set, the adjusted odds ratio was estimated to be 1.27 (95% CI: 1.14-1.41, p < 0.001; R(2) = 0.221). Our study was a quality improvement project that showed that microbiology laboratories can use the weight of blood culture bottles to determine if appropriate volume has been collected to improve the diagnosis of BSI.

  8. Does ultrasonographic volume of the thyroid gland correlate with difficult intubation? An observational study.

    PubMed

    Meco, Basak Ceyda; Alanoglu, Zekeriyya; Yilmaz, Ali Abbas; Basaran, Cumhur; Alkis, Neslihan; Demirer, Seher; Cuhruk, Handan

    2015-01-01

    Preoperative ultrasonographic evaluation of the thyroid gland done by surgeons could let us foresee airway management challenges. The aim of this observational study was to evaluate the effects of thyroid-related parameters assessed preoperatively by surgeons via ultrasonography and chest X-ray on intubation conditions. Fifty patients undergoing thyroid surgery were enrolled. Thyromental distance, Mallampati score, neck circumference and range of neck movement were evaluated before the operation. Thyroid volume, signs of invasion or compression and tracheal deviation on chest X-ray were also noted. The intubation conditions were assessed with Cormack and Lehane score and the intubation difficulty scale. Statistical analyses were done with SPSS 15.0 software. The mean thyroid volume of the patients was 26.38 ± 14 mL. The median intubation difficulty scale was 1 (0-2). Thyromental distance (p = 0.011; r = 0.36; 95% CI 0.582-0.088), Mallampati score (p = 0.041; r = 0.29; 95% CI 0.013-0.526), compression or invasion signs (p = 0.041; r = 0.28; 95% CI 0.006-0.521) and tracheal deviation on chest X-ray (p = 0.041; r = 0.52; 95% CI 0.268-0.702) were correlated with intubation difficulty scale. Also patients were classified into two groups related to their intubation difficulty scale (Group I, n = 19: intubation difficulty scale = 0; Group II, n = 31: 1< intubation difficulty scale ≤ 5) and difficult intubation predictors and thyroid-related parameters were compared. Only Mallampati score was significantly different between groups (p = 0.025). The thyroid volume is not associated with difficult intubation. However clinical assessment parameters may predict difficult intubation. Copyright © 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

  9. Testicular volume is inversely correlated with nurturing-related brain activity in human fathers.

    PubMed

    Mascaro, Jennifer S; Hackett, Patrick D; Rilling, James K

    2013-09-24

    Despite the well-documented benefits afforded the children of invested fathers in modern Western societies, some fathers choose not to invest in their children. Why do some men make this choice? Life History Theory offers an explanation for variation in parental investment by positing a trade-off between mating and parenting effort, which may explain some of the observed variance in human fathers' parenting behavior. We tested this hypothesis by measuring aspects of reproductive biology related to mating effort, as well as paternal nurturing behavior and the brain activity related to it. Both plasma testosterone levels and testes volume were independently inversely correlated with paternal caregiving. In response to viewing pictures of one's own child, activity in the ventral tegmental area--a key component of the mesolimbic dopamine reward and motivation system--predicted paternal caregiving and was negatively related to testes volume. Our results suggest that the biology of human males reflects a trade-off between mating effort and parenting effort, as indexed by testicular size and nurturing-related brain function, respectively.

  10. The correlation between gray matter volume and perceived social support: a voxel-based morphometry study.

    PubMed

    Che, XianWei; Wei, DongTao; Li, WenFu; Li, HaiJiang; Qiao, Lei; Qiu, Jiang; Zhang, QingLin; Liu, YiJun

    2014-01-01

    Social support refers to interpersonal exchanges that include the combinations of aid, affirmation and affection. Perceived social support is a kind of subjective judgment of one's availability of social support. In spite of the importance of perceived social support to health, however, its neural substrate remains unknown. To address this question, voxel-based morphometry was employed to investigate the neural bases of individual differences in responses to the Perceived Social Support Scale (PSSS) in healthy volunteers (144 men and 203 women; mean age = 19.9; SD = 1.33, age range : 17-27). As a result, multiple regression analysis revealed that the PSSS scores were significantly and positively correlated with gray matter volume in a cluster that mainly included areas in posterior parts of posterior cingulate cortex, bilateral lingual cortex, left occipital lobe and cuneus. Highly-supported individuals had larger gray matter volume in these brain regions, implying a relatively high level of ability to engage in self-referential processes and social cognition. Our results provide a biological basis for exploring perceived social support particularly in relationship to various health parameters and outcomes.

  11. Information content in fluorescence correlation spectroscopy: binary mixtures and detection volume distortion.

    PubMed

    Lam, Jonathan D; Culbertson, Michael J; Skinner, Nathan P; Barton, Zachary J; Burden, Daniel L

    2011-07-01

    When properly implemented, fluorescence correlation spectroscopy (FCS) reveals numerous static and dynamic properties of molecules in solution. However, complications arise whenever the measurement scenario is complex. Specific limitations occur when the detection region does not match the ideal Gaussian geometry ubiquitously assumed by FCS theory, or when properties of multiple fluorescent species are assessed simultaneously. A simple binary solution of diffusers, where both mole fraction and diffusion constants are sought, can face interpretive difficulty. In order to better understand the limits of FCS, this study systematically explores the relationship between detection-volume distortion, diffusion constants, species mole fraction, and fitting methodology in analyses that utilize a two-component autocorrelation model. FCS measurements from solution mixtures of dye-labeled protein and free dye are compared to simulations, which predict the performance of FCS under a variety of experimental circumstances. The results reveal a range of conditions necessary for performing accurate measurements and describe experimental scenarios that should be avoided. The findings also provide guidelines for obtaining meaningful measurements when grossly distorted detection volumes are utilized and generally assess the latent information contained in FCS datasets.

  12. Correlation of live-cell imaging with volume scanning electron microscopy.

    PubMed

    Lucas, Miriam S; Günthert, Maja; Bittermann, Anne Greet; de Marco, Alex; Wepf, Roger

    2017-01-01

    Live-cell imaging is one of the most widely applied methods in live science. Here we describe two setups for live-cell imaging, which can easily be combined with volume SEM for correlative studies. The first procedure applies cell culture dishes with a gridded glass support, which can be used for any light microscopy modality. The second approach is a flow-chamber setup based on Ibidi μ-slides. Both live-cell imaging strategies can be followed up with serial blockface- or focused ion beam-scanning electron microscopy. Two types of resin embedding after heavy metal staining and dehydration are presented making best use of the particular advantages of each imaging modality: classical en-bloc embedding and thin-layer plastification. The latter can be used only for focused ion beam-scanning electron microscopy, but is advantageous for studying cell-interactions with specific substrates, or when the substrate cannot be removed. En-bloc embedding has diverse applications and can be applied for both described volume scanning electron microscopy techniques. Finally, strategies for relocating the cell of interest are discussed for both embedding approaches and in respect to the applied light and scanning electron microscopy methods. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. The correlation between ArF resist dispense volume and surface tension

    NASA Astrophysics Data System (ADS)

    Kuo, Tung-Chang

    2013-04-01

    Resist spin coating has already been applied to IC industry for a very long time. Uniform spin coat of photoresist has been demonstrated on 12" wafers with conventional 6" and 8" methods. Meanwhile, resist dispense volume reduction has also been widely studied and investigated. In our paper, we focus on the physical properties of photoresist and prewet solvent. We try to figure out the interfacial behavior/mechanism between ArF resist and its related pre-wet solvent by systematic methods and DOE splits. In the experiments, different ArF resists among various solvent systems and two distinct pre-wet systems are tested and researched. Certain ArF resists generate smaller dispense volume compared with other PRs even under the same process condition. Eventually, from the splits we find out the trend which correlates to the interaction between resist and pre-wet solvent. The trend proves that our hypothesis is correct. The conclusion will contribute to our future resist selection. The conclusion will also provide new resist design concept to resist vendors. Basic studies and experiments are carried out under our limited resources, equipment and time. We have tried our best to find out the mechanism and have proved it.

  14. Pose Estimation using 1D Fourier Transform and Euclidean Distance Matching of CAD Model and Inspected Model Part

    NASA Astrophysics Data System (ADS)

    Zulkoffli, Zuliani; Abu Bakar, Elmi

    2016-02-01

    This paper present pose estimation relation of CAD model object and Projection Real Object (PRI). Image sequence of PRI and CAD model rotate on z axis at 10 degree interval in simulation and real scene used in this experiment. All this image is go through preprocessing stage to rescale object size and image size and transform all the image into silhouette. Correlation of CAD and PRI image is going through in this stage. Magnitude spectrum shows a reliable value in range 0.99 to 1.00 and Phase spectrum correlation shows a fluctuate graph in range 0.56 - 0.97. Euclidean distance correlation graph for CAD and PRI shows 2 zone of similar value due to almost symmetrical object shape. Processing stage of retrieval inspected PRI image in CAD database was carried out using range phase spectrum and maximum magnitude spectrum value within ±10% tolerance. Additional processing stage of retrieval inspected PRI image using Euclidean distance within ±5% tolerance also carried out. Euclidean matching shows a reliable result compared to range phase spectrum and maximum magnitude spectrum value by sacrificing more than 5 times processing time.

  15. Alterations in white matter volume and its correlation with clinical characteristics in patients with generalized anxiety disorder.

    PubMed

    Moon, Chung-Man; Jeong, Gwang-Woo

    2015-11-01

    Only a few morphological studies have focused on changes in white matter (WM) volume in patients with generalized anxiety disorder (GAD). We evaluated alterations in WM volume and its correlation with symptom severity and duration of illness in adults with GAD. The 44 subjects were comprised of 22 patients with GAD (13 males and nine females) diagnosed using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) and 22 age-matched healthy controls (13 males and nine females). High-resolution magnetic resonance imaging (MRI) data were processed by voxel-based morphometry (VBM) analysis based on diffeomorphic anatomical registration using the exponentiated Lie algebra (DARTEL) algorithm in SPM8. Patients with GAD showed significantly reduced WM volume, particularly in the dorsolateral prefrontal cortex (DLPFC), anterior limb of the internal capsule (ALIC), and midbrain. In addition, DLPFC volume was negatively correlated with GAD-7 score and illness duration. ALIC volume was negatively correlated with GAD-7 score. Female patients had significantly less orbitofrontal cortex volume compared to that in male patients. The findings demonstrate localized changes in WM volume associated with cognitive and emotional dysfunction in patients with GAD. The finding will be helpful for understanding the neuropathology in patients with GAD.

  16. White matter volume change and its correlation with symptom severity in patients with schizophrenia: a VBM-DARTEL study.

    PubMed

    Kim, Gwang-Won; Jeong, Gwang-Woo

    2015-12-16

    The aim of this study was to evaluate the white matter (WM) volume change and its correlation with symptom severity in patients with schizophrenia using voxel-based morphometry. A total of 20 patients with schizophrenia and 20 age-matched healthy controls participated in this study. MR image data were processed using SPM8 software with diffeomorphic anatomical registration through an exponentiated Lie algebra (DARTEL) algorithm. The patients with schizophrenia showed significant decreases (P=0.042) in the WM volumes of the temporal lobe and superior frontal gyrus compared with the healthy controls. The WM volumes of the middle temporal gyrus were negatively correlated with the scores of both the Positive Subscale (Pearson's ρ=-0.68, P=0.001) and the Negative Subscale (ρ=-0.71, P=0.0005) in the Positive and Negative Syndrome Scale. In addition, the scores of the General Psychopathology Subscale were negatively correlated with the WM volumes of the superior frontal gyrus (ρ=-0.68, P=0.0009). This study evaluated the WM volume of patients with schizophrenia compared with healthy controls using DARTEI-based voxel-based morphometry and also assessed the correlation of the localized WM volume changes with the Positive and Negative Syndrome Scale. These findings will be useful to understand the neuropathology associated with WM abnormality in schizophrenia.

  17. Tackling higher derivative ghosts with the Euclidean path integral

    SciTech Connect

    Fontanini, Michele; Trodden, Mark

    2011-05-15

    An alternative to the effective field theory approach to treat ghosts in higher derivative theories is to attempt to integrate them out via the Euclidean path integral formalism. It has been suggested that this method could provide a consistent framework within which we might tolerate the ghost degrees of freedom that plague, among other theories, the higher derivative gravity models that have been proposed to explain cosmic acceleration. We consider the extension of this idea to treating a class of terms with order six derivatives, and find that for a general term the Euclidean path integral approach works in the most trivial background, Minkowski. Moreover we see that even in de Sitter background, despite some difficulties, it is possible to define a probability distribution for tensorial perturbations of the metric.

  18. Riemannian Means on Special Euclidean Group and Unipotent Matrices Group

    PubMed Central

    Duan, Xiaomin; Sun, Huafei

    2013-01-01

    Among the noncompact matrix Lie groups, the special Euclidean group and the unipotent matrix group play important roles in both theoretic and applied studies. The Riemannian means of a finite set of the given points on the two matrix groups are investigated, respectively. Based on the left invariant metric on the matrix Lie groups, the geodesic between any two points is gotten. And the sum of the geodesic distances is taken as the cost function, whose minimizer is the Riemannian mean. Moreover, a Riemannian gradient algorithm for computing the Riemannian mean on the special Euclidean group and an iterative formula for that on the unipotent matrix group are proposed, respectively. Finally, several numerical simulations in the 3-dimensional case are given to illustrate our results. PMID:24282378

  19. Rigid body dynamics in non-Euclidean spaces

    NASA Astrophysics Data System (ADS)

    Borisov, A. V.; Mamaev, I. S.

    2016-10-01

    In this paper, we focus on the study of two-dimensional plate dynamics on the Lobachevskii plane L 2. First of all, we consider the free motion of such a plate, which is a pseudospherical analog of dynamics of the Euler top, and also present an analog of the Euler-Poisson equations enabling us to study the motion of the body in potential force fields having rotational symmetry. We present a series of integrable cases, having analogs in Euclidean space, for different fields. Moreover, in the paper, a partial qualitative analysis of the dynamics of free motion of a plate under arbitrary initial conditions is made and a number of computer illustrations are presented which show a substantial difference of the motion from the case of Euclidean space. The study undertaken in the present paper leads to interesting physical consequences, which enable us to detect the influence of curvature on the body dynamics.

  20. Euclidean to Minkowski Bethe-Salpeter amplitude and observables

    NASA Astrophysics Data System (ADS)

    Carbonell, J.; Frederico, T.; Karmanov, V. A.

    2017-01-01

    We propose a method to reconstruct the Bethe-Salpeter amplitude in Minkowski space given the Euclidean Bethe-Salpeter amplitude - or alternatively the light-front wave function - as input. The method is based on the numerical inversion of the Nakanishi integral representation and computing the corresponding weight function. This inversion procedure is, in general, rather unstable, and we propose several ways to considerably reduce the instabilities. In terms of the Nakanishi weight function, one can easily compute the BS amplitude, the LF wave function and the electromagnetic form factor. The latter ones are very stable in spite of residual instabilities in the weight function. This procedure allows both, to continue the Euclidean BS solution in the Minkowski space and to obtain a BS amplitude from a LF wave function.

  1. Correlations between ventricular enlargement and gray and white matter volumes of cortex, thalamus, striatum, and internal capsule in schizophrenia.

    PubMed

    Horga, Guillermo; Bernacer, Javier; Dusi, Nicola; Entis, Jonathan; Chu, Kingwai; Hazlett, Erin A; Haznedar, M Mehmet; Kemether, Eileen; Byne, William; Buchsbaum, Monte S

    2011-10-01

    Ventricular enlargement is one of the most consistent abnormal structural brain findings in schizophrenia and has been used to infer brain shrinkage. However, whether ventricular enlargement is related to local overlying cortex and/or adjacent subcortical structures or whether it is related to brain volume change globally has not been assessed. We systematically assessed interrelations of ventricular volumes with gray and white matter volumes of 40 Brodmann areas (BAs), the thalamus and its medial dorsal nucleus and pulvinar, the internal capsule, caudate and putamen. We acquired structural MRI ( patients with schizophrenia (n = 64) and healthy controls (n = 56)) and diffusion tensor fractional anisotropy (FA) (untreated schizophrenia n = 19, controls n = 32). Volumes were assessed by manual tracing of central structures and a semi-automated parcellation of BAs. Patients with schizophrenia had increased ventricular size associated with decreased cortical gray matter volumes widely across the brain; a similar but less pronounced pattern was seen in normal controls; local correlations (e.g. temporal horn with temporal lobe volume) were not appreciably higher than non-local correlations (e.g. temporal horn with prefrontal volume). White matter regions adjacent to the ventricles similarly did not reveal strong regional relationships. FA and center of mass of the anterior limb of the internal capsule also appeared differentially influenced by ventricular volume but findings were similarly not regional. Taken together, these findings indicate that ventricular enlargement is globally interrelated with gray matter volume diminution but not directly correlated with volume loss in the immediately adjacent caudate, putamen, or internal capsule.

  2. Correlators of left charges and weak operators in finite volume chiral perturbation theory

    NASA Astrophysics Data System (ADS)

    Hernández, Pilar; Laine, Mikko

    2003-01-01

    We compute the two-point correlator between left-handed flavour charges, and the three-point correlator between two left-handed charges and one strangeness violating DeltaI = 3/2 weak operator, at next-to-leading order in finite volume SU(3)L × SU(3)R chiral perturbation theory, in the so-called epsilon-regime. Matching these results with the corresponding lattice measurements would in principle allow to extract the pion decay constant F, and the effective chiral theory parameter g27, which determines the Delta I = 3/2 amplitude of the weak decays K to pipi as well as the kaon mixing parameter BK in the chiral limit. We repeat the calculations in the replica formulation of quenched chiral perturbation theory, finding only mild modifications. In particular, a properly chosen ratio of the three-point and two-point functions is shown to be identical in the full and quenched theories at this order.

  3. Optimal recovery of linear operators in non-Euclidean metrics

    SciTech Connect

    Osipenko, K Yu

    2014-10-31

    The paper looks at problems concerning the recovery of operators from noisy information in non-Euclidean metrics. A number of general theorems are proved and applied to recovery problems for functions and their derivatives from the noisy Fourier transform. In some cases, a family of optimal methods is found, from which the methods requiring the least amount of original information are singled out. Bibliography: 25 titles.

  4. Crosscap States for Orientifolds of Euclidean AdS3

    NASA Astrophysics Data System (ADS)

    Hikida, Yasuaki

    2002-05-01

    Crosscap states for orientifolds of euclidean AdS3 are constructed. We show that our crosscap states describe the same orientifolds which were obtained by the classical analysis. The spectral density of open strings in the system with orientifold can be read from the Möbius strip amplitudes and it is compared to that of the open strings stretched between branes and their mirrors. We also compute the Klein bottle amplitudes.

  5. Correlation of transrectal and transabodominal ultrasound measurement of transition zone volume with post-operative enucleated adenoma volume in benign prostatic hypertrophy.

    PubMed

    Ajayi, Idowu; Aremu, Ademola; Olajide, Abimbola; Bello, Tope; Olajide, Folake; Adetiloye, Victor

    2013-01-01

    Benign prostatic hyperplasia is a common disease of ageing men worldwide. Though transrectal ultrasonography (TRUS) is the standard in most parts of the world in evaluation of benign prostatic hyperplasia (BPH), it is rarely done in some less developed countries because of non availability of appropriate probes and or specialists. Transabdominal ultrasonography (TAUS) remains the mainstay in these areas. Some controversies still exist in literature about the accuracy of TAUS evaluation of prostatic volume in patients with BPH. This study aimed at comparing the transition zone volume estimation of the prostate on transrectal and transabdominal ultrasound with post-operative enucleated adenoma volume in Nigeria patients with BPH and to suggest better predictor of prostate volume in evaluation of BPH. Forty-six (46) patients with lower urinary tract symptoms due to BPH attending the urologic clinic were evaluated ultrasonographically and eventually managed with open surgery (prostatectomy) after due counselling. The post operative samples were weighted using a sensitive top loading weighing balance and converted to volume. Since the specific gravity of the prostate is equivalent to that of water,the weight is the same as volume. Patients' ages ranged between 59 and 90 years with a peak age incidence at seventh decade. Transition Zone (TZ) volume estimation on both transrectal and transabdominal ultrasound showed positive correlation with the post operative enucleated adenoma(r = 0.594, p < 0.001) but the transrectal method was more accurate. There was no significant relationship between the TZ volume and patients' symptoms(r = 0.491, p = 0.007). Both TRUS and TAUS are comparable at TZ volume estimation and therefore TAUS can be utilized in regions where intracavitary probes and or the expertise is/are not available.

  6. Dyslexia and voxel-based morphometry: correlations between five behavioural measures of dyslexia and gray and white matter volumes.

    PubMed

    Tamboer, Peter; Scholte, H Steven; Vorst, Harrie C M

    2015-10-01

    In voxel-based morphometry studies of dyslexia, the relation between causal theories of dyslexia and gray matter (GM) and white matter (WM) volume alterations is still under debate. Some alterations are consistently reported, but others failed to reach significance. We investigated GM alterations in a large sample of Dutch students (37 dyslexics and 57 non-dyslexics) with two analyses: group differences in local GM and total GM and WM volume and correlations between GM and WM volumes and five behavioural measures. We found no significant group differences after corrections for multiple comparisons although total WM volume was lower in the group of dyslexics when age was partialled out. We presented an overview of uncorrected clusters of voxels (p < 0.05, cluster size k > 200) with reduced or increased GM volume. We found four significant correlations between factors of dyslexia representing various behavioural measures and the clusters found in the first analysis. In the whole sample, a factor related to performances in spelling correlated negatively with GM volume in the left posterior cerebellum. Within the group of dyslexics, a factor related to performances in Dutch-English rhyme words correlated positively with GM volume in the left and right caudate nucleus and negatively with increased total WM volume. Most of our findings were in accordance with previous reports. A relatively new finding was the involvement of the caudate nucleus. We confirmed the multiple cognitive nature of dyslexia and suggested that experience greatly influences anatomical alterations depending on various subtypes of dyslexia, especially in a student sample.

  7. Multifractal detrended fluctuation analysis based on fractal fitting: The long-range correlation detection method for highway volume data

    NASA Astrophysics Data System (ADS)

    Dai, Meifeng; Hou, Jie; Ye, Dandan

    2016-02-01

    In this paper, we investigate the traffic time series for volume data observed on the Guangshen highway. We introduce a multifractal detrended fluctuation analysis based on fractal fitting (MFDFA-FF), which is one of the most effective methods to detect long-range correlations of time series. Through effective detecting of long-range correlations, highway volume can be predicted more accurately. In order to get a better detrend effect, we use fractal fitting to replace polynomial fitting in detrend process, the result shows that fractal fitting can get a better detrend effect than polynomial fitting and the MFDFA-FF method can achieve a more accurate research result. Then we introduce the Legendre spectrum to detect the multifractal property characterized by the long-range correlation and multifractality of Guangshen highway volume data.

  8. Path integration and perturbation theory with complex Euclidean actions

    SciTech Connect

    Alexanian, Garnik; MacKenzie, R.; Paranjape, M. B.; Ruel, Jonathan

    2008-05-15

    The Euclidean path integral quite often involves an action that is not completely real, i.e. a complex action. This occurs when the Minkowski action contains t-odd CP-violating terms. This usually consists of topological terms, such as the Chern-Simons term in odd dimensions, the Wess-Zumino term, the {theta} term or Chern character in 4-dimensional gauge theories, or other topological densities. Analytic continuation to Euclidean time yields an imaginary term in the Euclidean action. It also occurs when the action contains fermions, the fermion path integral being in general a sum over positive and negative real numbers. Negative numbers correspond to the exponential of i{pi} and hence indicate the presence of an imaginary term in the action. In the presence of imaginary terms in the Euclidean action, the usual method of perturbative quantization can fail. Here the action is expanded about its critical points, the quadratic part serving to define the Gaussian free theory and the higher order terms defining the perturbative interactions. For a complex action, the critical points are generically obtained at complex field configurations. Hence the contour of path integration does not pass through the critical points and the perturbative paradigm cannot be directly implemented. The contour of path integration has to be deformed to pass through the complex critical point using a generalized method of steepest descent, in order to do so. Typically, this procedure is not followed. Rather, only the real part of the Euclidean action is considered, and its critical points are used to define the perturbation theory, a procedure that can lead to incorrect results. In this article we present a simple example to illustrate this point. The example consists of N scalar fields in 0+1 dimensions interacting with a U(1) gauge field in the presence of a Chern-Simons term. In this example the path integral can be done exactly, the procedure of deformation of the contour of path

  9. Lagrangian Coherent Structures in a Non-Euclidean Global Thermosphere

    NASA Astrophysics Data System (ADS)

    Wang, N.; Ramirez, U.; Flores, F.; Datta-Barua, S.

    2016-12-01

    Lagrangian Coherent Structures (LCSs) are manifolds of maximum divergence or convergence in 2D or 3D time-varying flow fields. The study of LCSs has been used to predict material transport in numerous geophysical flows. The most commonly used computational method for finding LCSs is to compute the finite time Lyapunov exponent (FTLE), a scalar field measuring the ratio of stretching after a given interval of time among neighboring particles, relative to their initial separation. LCS ridges are located at the local maxima of the FTLE. The LCS must be objective (frame-invariant for different observers), and the technique for computing the FTLE that determines the LCS typically assumes a Euclidean domain. Previous work showed that LCSs are likely to exist globally at high latitudes using the Euclidean norm. Here we refine that calculation by deriving the FTLE calculation for the Riemannian manifold of a spherical surface, and applying it to the thermospheric layer of the atmosphere globally. The thermosphere is treated as a closed spherical 2D domain on which the fluid flows, assuming negligible vertical flow. The domain is discretized in longitude and latitude, and the Horizontal Wind Model 2014 (HWM14) is used to generate the 2D velocity field at each grid point, each of which is a ground speed in the local east-north-up (ENU) frame. To make the LCS objective, the ground speed in each local ENU frame is converted to angular velocity in the earth-centered earth-fixed (ECEF) coordinates. Using bilinear interpolation and including the rotational velocity of Earth to transform to an inertial frame, we trace the trajectory of each particle to compute the final positions after the integration time. Replacing the Euclidean distance between particles with the great circle distance gives the FTLE scalar field from which the LCSs can be identified. We find and illustrate objective LCSs in the neutral wind flow field at high latitudes by applying this algorithm for the

  10. Striatal Volume Increases in Active Methamphetamine-Dependent Individuals and Correlation with Cognitive Performance

    PubMed Central

    Jan, Reem K.; Lin, Joanne C.; Miles, Sylvester W.; Kydd, Rob R.; Russell, Bruce R.

    2012-01-01

    The effect of methamphetamine (MA) dependence on the structure of the human brain has not been extensively studied, especially in active users. Previous studies reported cortical deficits and striatal gains in grey matter (GM) volume of abstinent MA abusers compared with control participants. This study aimed to investigate structural GM changes in the brains of 17 active MA-dependent participants compared with 20 control participants aged 18–46 years using voxel-based morphometry and region of interest volumetric analysis of structural magnetic resonance imaging data, and whether these changes might be associated with cognitive performance. Significant volume increases were observed in the right and left putamen and left nucleus accumbens of MA-dependent compared to control participants. The volumetric gain in the right putamen remained significant after Bonferroni correction, and was inversely correlated with the number of errors (standardised z-scores) on the Go/No-go task. MA-dependent participants exhibited cortical GM deficits in the left superior frontal and precentral gyri in comparison to control participants, although these findings did not survive correction for multiple comparisons. In conclusion, consistent with findings from previous studies of abstinent users, active chronic MA-dependent participants showed significant striatal enlargement which was associated with improved performance on the Go/No-go, a cognitive task of response inhibition and impulsivity. Striatal enlargement may reflect the involvement of neurotrophic effects, inflammation or microgliosis. However, since it was associated with improved cognitive function, it is likely to reflect a compensatory response to MA-induced neurotoxicity in the striatum, in order to maintain cognitive function. Follow-up studies are recommended to ascertain whether this effect continues to be present following abstinence. Several factors may have contributed to the lack of more substantial cortical and

  11. Measuring grade-school children's ability to represent the Euclidean horizontal coordinate.

    PubMed

    De Lisi, R; McGillicuddy-De Lisi, A V; Mowrer-Popiel, E

    1995-06-01

    Seventy-five grade-school children were administered three tasks that measured their ability to represent the Euclidean horizontal coordinate: a traditional water-level test (WLT) that used a square-shaped vessel, a WLT that used a spherical vessel, and a task that used a crossbar apparatus. The latter two tasks differed from the traditional task in terms of the degree to which the apparatus presented a frame of reference that conflicted with environmental Euclidean coordinates. Performance was analyzed according to Piaget and Inhelder's (1956) stage-scoring system; that is, the testing procedures (a) allowed children to inspect the apparatus when it was rotated to discrete orientations; (b) corrected initial errors; and (c) included 0 degrees, 30 degrees, 60 degrees, and 90 degrees trials. Age-related stages were identified on each task. Levels of performance on one task were significantly correlated with levels on each of the other two tasks. Performance was less accurate on the traditional WLT than on either of the other two measures. These results provide evidence of the validity of the alternative tasks to measure children's horizontality representation. The findings suggest that horizontality assessment procedures should include orthogonal and oblique rotations and contain an inspection phase. Use of apparatuses with conflicting frames of reference renders tasks more difficult but is not necessary to observe age-related developmental progress during the grade-school years.

  12. Correlation Between Biomechanical Responses of Posterior Sclera and IOP Elevations During Micro Intraocular Volume Change

    PubMed Central

    Morris, Hugh J.; Tang, Junhua; Cruz Perez, Benjamin; Pan, Xueliang; Hart, Richard T.; Weber, Paul A.; Liu, Jun

    2013-01-01

    Purpose. This study tested the hypothesis that intraocular pressure (IOP) elevations, induced by controlled increase of intraocular volume, are correlated with the biomechanical responses of the posterior sclera. Methods. Porcine globes were tested within 48 hours postmortem. The first group of globes (n = 11) was infused with 15 μL of phosphate-buffered saline at three different rates to investigate rate-dependent IOP elevations. The second group (n = 16) was first infused at the fast rate and then underwent inflation tests to investigate the relationship between IOP elevations (ΔIOP) and scleral strains. The strains in the superotemporal region of the posterior sclera were measured by ultrasound speckle tracking. Linear regression was used to examine the association between ΔIOP due to micro-volumetric infusion and the scleral strains at a specific inflation pressure. Results. The average ΔIOP was 14.9 ± 4.3 mm Hg for the infusion of 15 μL in 1 second. The ΔIOP was greater for the faster infusion rates but highly correlated across different rates (P < 0.001). A significant negative association was found between the ΔIOP and the tangential strains in both the circumferential (R2 = 0.54, P = 0.003) and meridian (R2 = 0.53, P = 0.002) directions in the posterior sclera. Conclusions. This study showed a substantial increase in IOP, with a large intersubject variance during micro-volumetric change. A stiffer response of the sclera was associated with larger IOP spikes, providing experimental evidence linking corneoscleral biomechanics to IOP fluctuation. In vivo measurement of corneoscleral biomechanics may help better predict the dynamic profile of IOP. PMID:24130185

  13. Clinical correlates of thalamus volume deficits in anti-psychotic-naïve schizophrenia patients: A 3-Tesla MRI study.

    PubMed

    Rao, Naren P; Kalmady, Sunil; Arasappa, Rashmi; Venkatasubramanian, Ganesan

    2010-07-01

    Thalamus, the sensory and motor gateway to the cortex, plays an important role in cognitive and perceptual disturbances in schizophrenia. Studies examining the volume of the thalamus in schizophrenia have reported conflicting findings due to the presence of potential confounding factors such as low-resolution imaging and anti-psychotics. The thalamus volume in anti-psychotic-naïve patients determined using high-resolution 3-Tesla magnetic resonance imaging (MRI) has not yet been examined. Using 3-Tesla MRI, this study for the first time examined anti-psychotic-naïve schizophrenia patients (n=18; M:F:11:7) in comparison with healthy controls (n=19;M:F:9:10) group-matched for age, sex, handedness, education, and socioeconomic status. The volume of the thalamus was measured using a three-dimensional, interactive, semi-automated analysis with good inter-rater and intra-rater reliability. Psychopathology was assessed using the Scale for Assessment of Negative Symptoms (SANS) and the Scale for Assessment of Positive Symptoms (SAPS). Right, left, and total thalamus volumes of patients were significantly smaller than those of controls after controlling for the potential confounding effect of intracranial volume. Thalamus volumes had significant positive correlation with positive symptoms score (SAPS) and significant negative correlation with negative symptoms score (SANS). Thalamus volume deficits in anti-psychotic-naïve schizophrenia patients support a neurodevelopmental pathogenesis. The contrasting correlation of thalamus volume deficits with psychopathology scores suggests that contrasting pruning aberrations underlie symptom genesis in schizophrenia.

  14. Tissue Doppler of early mitral filling correlates with simulated volume loss in healthy subjects.

    PubMed

    Moore, Christopher L; Tham, Edward T; Samuels, Kathleen J; McNamara, Robert L; Galante, Nicholas J; Stachenfeld, Nina; Shelley, Kirk; Dziura, James; Silverman, David G

    2010-11-01

    The accurate noninvasive assessment of preload in emergency department (ED) patients remains elusive. Point-of-care ultrasound (US) imaging, particularly evaluation of the inferior vena cava (IVC), has been shown to be qualitatively helpful. Doppler and tissue Doppler are now routinely available on ED US equipment, but few studies have looked at the correlation of dynamic changes in these parameters in a controlled model of hypovolemia. Our objective was to examine the correlation of Doppler parameters to simulated volume loss in healthy subjects using a lower-body negative pressure (LBNP) model and to compare these measurements to commonly used IVC measurements of preload. Twelve paid volunteers with no known cardiovascular disease between the ages of 23 and 31 years old (mean ± SD = 25.5 ± 2.5 years old) were recruited. Hypovolemia was simulated using graduated LBNP levels with measurements taken at 0, -30, and -60 mm Hg and lower pressures as tolerated. Vital signs were monitored in all patients. US measurements recorded at each negative pressure level included IVC maximum (IVC(max)) and minimum (IVC(min)) dimensions; early (E) and late (A) transmitral filling velocities using pulsed-wave spectral Doppler; and early (E') and late (A') tissue Doppler velocities at the septal ((sep)) and lateral ((lat)) mitral annulus, using pulsed-wave tissue Doppler. Lower-body negative pressure correlated significantly and positively within subjects for all US parameters except for the A filling wave. E'(lat) and E'(sep) showed the strongest correlation with R² values of 0.749 (95% confidence interval [CI] = 0.577 to 0.854) and 0.738 (95% CI = 0.579 to 0.875) respectively, followed by A'(sep) 0.674 (95% CI = 0.416 to 0.845), IVC(max) 0.638 (95% CI = 0.425 to 0.806), A'(lat) 0.547 (95% CI = 0.280 to 0.802), IVC(min) 0.512 (95% CI = 0.192 to 0.777), and E 0.478 (95% CI = 0.187 to 0.762). Ratios correlated only moderately with LBNP level, including E/ E'(lat) R² of 0.430 (95

  15. Accurate B-spline-based 3-D interpolation scheme for digital volume correlation

    NASA Astrophysics Data System (ADS)

    Ren, Maodong; Liang, Jin; Wei, Bin

    2016-12-01

    An accurate and efficient 3-D interpolation scheme, based on sampling theorem and Fourier transform technique, is proposed to reduce the sub-voxel matching error caused by intensity interpolation bias in digital volume correlation. First, the influence factors of the interpolation bias are investigated theoretically using the transfer function of an interpolation filter (henceforth filter) in the Fourier domain. A law that the positional error of a filter can be expressed as a function of fractional position and wave number is found. Then, considering the above factors, an optimized B-spline-based recursive filter, combining B-spline transforms and least squares optimization method, is designed to virtually eliminate the interpolation bias in the process of sub-voxel matching. Besides, given each volumetric image containing different wave number ranges, a Gaussian weighting function is constructed to emphasize or suppress certain of wave number ranges based on the Fourier spectrum analysis. Finally, a novel software is developed and series of validation experiments were carried out to verify the proposed scheme. Experimental results show that the proposed scheme can reduce the interpolation bias to an acceptable level.

  16. Accurate B-spline-based 3-D interpolation scheme for digital volume correlation.

    PubMed

    Ren, Maodong; Liang, Jin; Wei, Bin

    2016-12-01

    An accurate and efficient 3-D interpolation scheme, based on sampling theorem and Fourier transform technique, is proposed to reduce the sub-voxel matching error caused by intensity interpolation bias in digital volume correlation. First, the influence factors of the interpolation bias are investigated theoretically using the transfer function of an interpolation filter (henceforth filter) in the Fourier domain. A law that the positional error of a filter can be expressed as a function of fractional position and wave number is found. Then, considering the above factors, an optimized B-spline-based recursive filter, combining B-spline transforms and least squares optimization method, is designed to virtually eliminate the interpolation bias in the process of sub-voxel matching. Besides, given each volumetric image containing different wave number ranges, a Gaussian weighting function is constructed to emphasize or suppress certain of wave number ranges based on the Fourier spectrum analysis. Finally, a novel software is developed and series of validation experiments were carried out to verify the proposed scheme. Experimental results show that the proposed scheme can reduce the interpolation bias to an acceptable level.

  17. Cerebral blood volume in Alzheimer's disease and correlation with tissue structural integrity.

    PubMed

    Uh, Jinsoo; Lewis-Amezcua, Kelly; Martin-Cook, Kristin; Cheng, Yamei; Weiner, Myron; Diaz-Arrastia, Ramon; Devous, Michael; Shen, Dinggang; Lu, Hanzhang

    2010-12-01

    A vascular component is increasingly recognized as important in Alzheimer's disease (AD). We measured cerebral blood volume (CBV) in patients with probable AD or Mild Cognitive Impairment (MCI) and in elderly non-demented subjects using a recently developed Vascular-Space-Occupancy (VASO) MRI technique. While both gray and white matters were examined, significant CBV deficit regions were primarily located in white matter, specifically in frontal and parietal lobes, in which CBV was reduced by 20% in the AD/MCI group. The regions with CBV deficit also showed reduced tissue structural integrity as indicated by increased apparent diffusion coefficients, whereas in regions without CBV deficits no such correlation was found. Subjects with lower CBV tended to have more white matter lesions in FLAIR MRI images and showed slower psychomotor speed. These data suggest that the vascular contribution in AD is primarily localized to frontal/parietal white matter and is associated with brain tissue integrity. Copyright © 2008 Elsevier Inc. All rights reserved.

  18. Two-dimensional ultrasound measurement of thyroid gland volume: a new equation with higher correlation with 3-D ultrasound measurement.

    PubMed

    Ying, Michael; Yung, Dennis M C; Ho, Karen K L

    2008-01-01

    This study aimed to develop a new two-dimensional (2-D) ultrasound thyroid volume estimation equation using three-dimensional (3-D) ultrasound as the standard of reference, and to compare the thyroid volume estimation accuracy of the new equation with three previously reported equations. 2-D and 3-D ultrasound examinations of the thyroid gland were performed in 150 subjects with normal serum thyrotropin (TSH, thyroid-stimulating hormone) and free thyroxine (fT4) levels (63 men and 87 women, age range: 17 to 71 y). In each subject, the volume of both thyroid lobes was measured by 3-D ultrasound. On 2-D ultrasound, the craniocaudal (CC), lateromedial (LM) and anteroposterior (AP) dimensions of the thyroid lobes were measured. The equation was derived by correlating the volume of the thyroid lobes measured with 3-D ultrasound and the product of the three dimensions measured with 2-D ultrasound using linear regression analysis, in 75 subjects without thyroid nodule. The accuracy of thyroid volume estimation of the new equation and the three previously reported equations was evaluated and compared in another 75 subjects (without thyroid nodule, n = 30; with thyroid nodule, n = 45). It is suggested that volume of thyroid lobe may be estimated as: volume of thyroid lobe = 0.38.(CC.LM.AP) + 1.76. Result showed that the new equation (16.9% to 36.1%) had a significantly smaller thyroid volume estimation error than the previously reported equations (20.8% to 54.9%) (p < 0.05). There was a significantly larger thyroid volume estimation error when thyroid glands with nodules were examined (p < 0.05). With the use of the appropriate thyroid volume equation, 2-D ultrasound can be a useful alternative in thyroid volume measurement when 3-D ultrasound is not available.

  19. The asphericity of the metabolic tumour volume in NSCLC: correlation with histopathology and molecular markers.

    PubMed

    Apostolova, Ivayla; Ego, Kilian; Steffen, Ingo G; Buchert, Ralph; Wertzel, Heinz; Achenbach, H Jost; Riedel, Sandra; Schreiber, Jens; Schultz, Meinald; Furth, Christian; Derlin, Thorsten; Amthauer, Holger; Hofheinz, Frank; Kalinski, Thomas

    2016-12-01

    Asphericity (ASP) is a tumour shape descriptor based on the PET image. It quantitates the deviation from spherical of the shape of the metabolic tumour volume (MTV). In order to identify its biological correlates, we investigated the relationship between ASP and clinically relevant histopathological and molecular signatures in non-small-cell lung cancer (NSCLC). The study included 83 consecutive patients (18 women, aged 66.4 ± 8.9 years) with newly diagnosed NSCLC in whom PET/CT with (18)F-FDG had been performed prior to therapy. Primary tumour resection specimens and core biopsies were used for basic histopathology and determination of the Ki-67 proliferation index. EGFR status, VEGF, p53 and ALK expression were obtained in a subgroup of 44 patients. The FDG PET images of the primary tumours were delineated using an automatic algorithm based on adaptive thresholding taking into account local background. In addition to ASP, SUVmax, MTV and some further descriptors of shape and intratumour heterogeneity were assessed as semiquantitative PET measures. SUVmax, MTV and ASP were associated with pathological T stage (Kruskal-Wallis, p = 0.001, p < 0.0005 and p < 0.0005, respectively) and N stage (p = 0.017, p = 0.003 and p = 0.002, respectively). Only ASP was associated with M stage (p = 0.026). SUVmax, MTV and ASP were correlated with Ki-67 index (Spearman's rho = 0.326/p = 0.003, rho = 0.302/p = 0.006 and rho = 0.271/p = 0.015, respectively). The latter correlations were considerably stronger in adenocarcinomas than in squamous cell carcinomas. ASP, but not SUVmax or MTV, showed a tendency for a significant association with the extent of VEGF expression (p = 0.058). In multivariate Cox regression analysis, ASP (p < 0.0005) and the presence of distant metastases (p = 0.023) were significantly associated with progression-free survival. ASP (p = 0.006), the presence of distant metastases (p

  20. Power-law correlations in finance-related Google searches, and their cross-correlations with volatility and traded volume: Evidence from the Dow Jones Industrial components

    NASA Astrophysics Data System (ADS)

    Kristoufek, Ladislav

    2015-06-01

    We study power-law correlations properties of the Google search queries for Dow Jones Industrial Average (DJIA) component stocks. Examining the daily data of the searched terms with a combination of the rescaled range and rescaled variance tests together with the detrended fluctuation analysis, we show that the searches are in fact power-law correlated with Hurst exponents between 0.8 and 1.1. The general interest in the DJIA stocks is thus strongly persistent. We further reinvestigate the cross-correlation structure between the searches, traded volume and volatility of the component stocks using the detrended cross-correlation and detrending moving-average cross-correlation coefficients. Contrary to the universal power-law correlations structure of the related Google searches, the results suggest that there is no universal relationship between the online search queries and the analyzed financial measures. Even though we confirm positive correlation for a majority of pairs, there are several pairs with insignificant or even negative correlations. In addition, the correlations vary quite strongly across scales.

  1. Barbero-Immirzi parameter, manifold invariants and Euclidean path integrals

    NASA Astrophysics Data System (ADS)

    Liko, Tomáš

    2012-05-01

    The Barbero-Immirzi parameter γ appears in the real connection formulation of gravity in terms of the Ashtekar variables, and gives rise to a one-parameter quantization ambiguity in loop quantum gravity. In this paper, we investigate the conditions under which γ will have physical effects in Euclidean quantum gravity. This is done by constructing a well-defined Euclidean path integral for the Holst action with a non-zero cosmological constant on a manifold with a boundary. We find that two general conditions must be satisfied by the spacetime manifold in order for the Holst action and its surface integral to be non-zero: (i) the metric has to be non-diagonalizable; (ii) the Pontryagin number of the manifold has to be non-zero. The latter is a strong topological condition and rules out many of the known solutions to the Einstein field equations. This result leads us to evaluate the on-shell first-order Holst action and corresponding Euclidean partition function on the Taub-NUT-ADS solution. We find that γ shows up as a finite rotation of the on-shell partition function which corresponds to shifts in the energy and entropy of the NUT charge. In an appendix, we also evaluate the Holst action on the Taub-NUT and Taub-bolt solutions in flat spacetime and find that in that case as well γ shows up in the energy and entropy of the NUT and bolt charges. We also present an example whereby the Euler characteristic of the manifold has a non-trivial effect on black hole mergers. Communicated by PRLV Moniz

  2. Orientation Maps in V1 and Non-Euclidean Geometry.

    PubMed

    Afgoustidis, Alexandre

    2015-12-01

    In the primary visual cortex, the processing of information uses the distribution of orientations in the visual input: neurons react to some orientations in the stimulus more than to others. In many species, orientation preference is mapped in a remarkable way on the cortical surface, and this organization of the neural population seems to be important for visual processing. Now, existing models for the geometry and development of orientation preference maps in higher mammals make a crucial use of symmetry considerations. In this paper, we consider probabilistic models for V1 maps from the point of view of group theory; we focus on Gaussian random fields with symmetry properties and review the probabilistic arguments that allow one to estimate pinwheel densities and predict the observed value of π. Then, in order to test the relevance of general symmetry arguments and to introduce methods which could be of use in modeling curved regions, we reconsider this model in the light of group representation theory, the canonical mathematics of symmetry. We show that through the Plancherel decomposition of the space of complex-valued maps on the Euclidean plane, each infinite-dimensional irreducible unitary representation of the special Euclidean group yields a unique V1-like map, and we use representation theory as a symmetry-based toolbox to build orientation maps adapted to the most famous non-Euclidean geometries, viz. spherical and hyperbolic geometry. We find that most of the dominant traits of V1 maps are preserved in these; we also study the link between symmetry and the statistics of singularities in orientation maps, and show what the striking quantitative characteristics observed in animals become in our curved models.

  3. Correlative light and volume electron microscopy: using focused ion beam scanning electron microscopy to image transient events in model organisms.

    PubMed

    Bushby, Andrew J; Mariggi, Giovanni; Armer, Hannah E J; Collinson, Lucy M

    2012-01-01

    The study of a biological event within a live model organism has become routine through the use of fluorescent labeling of specific proteins in conjunction with laser confocal imaging. These methods allow 3D visualization of temporal events that can elucidate biological function but cannot resolve the tissue organization, extracellular and subcellular details of the tissues. Here, we present a method for correlating electron microscopy image data with the light microscopy data from the same sample volume to reveal the 3D structural information: "correlative light and volume electron microscopy." The methods for live video confocal microscopy, fixation and embedding of the tissue for electron microscopy, the focused ion beam scanning electron microscopy method for sequentially slicing and imaging the volume of interest, and the treatment of the resulting 3D dataset are presented. The method is illustrated with data collected during the angiogenesis of blood vessels in a transgenic zebrafish embryo. Copyright © 2012 Elsevier Inc. All rights reserved.

  4. Two-photon two-focus fluorescence correlation spectroscopy with a tunable distance between the excitation volumes.

    PubMed

    Didier, Pascal; Godet, Julien; Mély, Yves

    2009-05-01

    In the present work, a Michelson interferometer was combined with a two-photon excitation microscope to perform two-focus Fluorescence Correlation Spectroscopy. This simple and original approach allows us to tune the distance between the two excitation volumes and determine absolute diffusion constants. The technique was validated on different model systems that demonstrate the sensitivity of the approach.

  5. Multi-stability in folded shells: non-Euclidean origami

    NASA Astrophysics Data System (ADS)

    Evans, Arthur

    2015-03-01

    Both natural and man-made structures benefit from having multiple mechanically stable states, from the quick snapping motion of hummingbird beaks to micro-textured surfaces with tunable roughness. Rather than discuss special fabrication techniques for creating bi-stability through material anisotropy, in this talk I will present several examples of how folding a structure can modify the energy landscape and thus lead to multiple stable states. Using ideas from origami and differential geometry, I will discuss how deforming a non-Euclidean surface can be done either continuously or discontinuously, and explore the effects that global constraints have on the ultimate stability of the surface.

  6. SU-E-J-249: Correlation of Mean Lung Ventilation Value with Ratio of Total Lung Volumes

    SciTech Connect

    Yu, N; Qu, H; Xia, P

    2014-06-01

    Purpose: Lung ventilation function measured from 4D-CT and from breathing correlated CT images is a novel concept to incorporate the lung physiologic function into treatment planning of radiotherapy. The calculated ventilation functions may vary from different breathing patterns, affecting evaluation of the treatment plans. The purpose of this study is to correlate the mean lung ventilation value with the ratio of the total lung volumes obtained from the relevant CTs. Methods: A ventilation map was calculated from the variations of voxel-to-voxel CT densities from two breathing phases from either 4D-CT or breathing correlated CTs. An open source image registration tool of Plastimatch was used to deform the inhale phase images to the exhale phase images. To calculate the ventilation map inside lung, the whole lung was delineated and the tissue outside the lung was masked out. With a software tool developed in house, the 3D ventilation map was then converted in the DICOM format associated with the planning CT images. The ventilation map was analyzed on a clinical workstation. To correlate ventilation map thus calculated with lung volume change, the total lung volume change was compared the mean ventilation from our method. Results: Twenty two patients who underwent stereotactic body irradiation for lung cancer was selected for this retrospective study. For this group of patients, the ratio of lung volumes for the inhale (Vin ) and exhale phase (Vex ) was shown to be linearly related to the mean of the local ventilation (Vent), Vin/Vex=1.+0.49*Vent (R2=0.93, p<0.01). Conclusion: The total lung volume change is highly correlated with the mean of local ventilation. The mean of local ventilation may be useful to assess the patient's lung capacity.

  7. How dose sparing of cardiac structures correlates with in-field heart volume and sternal displacement.

    PubMed

    Kim, Taeho; Reardon, Kelli; Trifiletti, Daniel M; Geesey, Constance; Sukovich, Kaitlyn; Crandley, Edwin; Read, Paul W; Wijesooriya, Krishni

    2016-11-01

    Cardiac irradiation increases the risk of coronary artery disease in patients with left-sided breast cancer. Techniques exist to reduce cardiac irradiation, but the optimum technique depends on individual patient anatomy and physiology. We investigated the correlation of delta heart volume in field (dHVIF) and sternal excursion with dose sparing in heart and left anterior descending artery (LAD) to develop quantitative predictive models for expected dose to heart and LAD. A treatment planning study was performed on 97 left-breast cancer patients who underwent whole breast radiotherapy (prescription dose = 50 Gy) under deep inspiratory breath hold (DIBH). Two CT datasets, free breathing (FB) and DIBH, were utilized for treatment planning and for determination of the internal anatomy-based DIBH amplitude. The mean heart and LAD dose were compared between FB and DIBH plans and dose to the heart and LAD as a function of dHVIF and sternal excursion were determined. The [Average (STD); Range] mean heart doses from free breathing and DIBH are [ 120.5(65.2); 28.9 ~ 393.8 ] cGy and [ 67.5(25.1); 19.7 ~ 145.6 ] cGy, respectively. The mean LAD doses from free breathing and DIBH are [ 571.0(582.2); 42.2 ~ 2332.2 ] cGy and [ 185.9(127.0); 41.2 ~ 898.4 ] cGy, respectively. The mean dose reductions with DIBH are [ 53.1(50.6); -15.4 ~ 295.1 ] cGy for the heart and [ 385.1(513.4); -0.6 ~ 2105.8 ] cGy for LAD. Percent mean dose reductions to the heart and LAD with DIBH are 44% (p < 0.0001) and 67% (p < 0.0001), respectively, compared to FB. The dHVIF mean dose reduction correlation is 8.1 cGy/cc for the heart and 81.6 cGy/cc for LAD (with linear trend and y intercept: 26.0 cGy for the heart, 109.1 cGy for LAD). DIBH amplitude using sternal position was [ 1.3(4.8); .38 ~2.5 ] cm. The DIBH amplitude mean dose reduction correlation is 14 cGy/cm for the heart and 212 cGy/cm for LAD (with linear trend with y

  8. How dose sparing of cardiac structures correlates with in-field heart volume and sternal displacement.

    PubMed

    Kim, Taeho; Reardon, Kelli; Trifiletti, Daniel M; Geesey, Constance; Sukovich, Kaitlyn; Crandley, Edwin; Read, Paul W; Wijesooriya, Krishni

    2016-11-08

    Cardiac irradiation increases the risk of coronary artery disease in patients with left-sided breast cancer. Techniques exist to reduce cardiac irradiation, but the optimum technique depends on individual patient anatomy and physiology. We investigated the correlation of delta heart volume in field (dHVIF) and sternal excursion with dose sparing in heart and left anterior descending artery (LAD) to develop quantitative predictive models for expected dose to heart and LAD. A treatment planning study was performed on 97 left-breast cancer patients who underwent whole breast radiotherapy (prescription dose = 50 Gy) under deep inspiratory breath hold (DIBH). Two CT datasets, free breathing (FB) and DIBH, were utilized for treatment planning and for determination of the internal anatomy-based DIBH amplitude. The mean heart and LAD dose were compared between FB and DIBH plans and dose to the heart and LAD as a function of dHVIF and sternal excursion were determined. The [Average (STD); Range] mean heart doses from free breathing and DIBH are [120.5(65.2); 28.9 ~ 393.8] cGy and [67.5(25.1); 19.7 ~ 145.6] cGy, respectively. The mean LAD doses from free breathing and DIBH are [571.0(582.2); 42.2 ~ 2332.2] cGy and [185.9(127.0); 41.2 ~ 898.4] cGy, respectively. The mean dose reductions with DIBH are [53.1(50.6); -15.4 ~ 295.1] cGy for the heart and [385.1(513.4); -0.6 ~ 2105.8] cGy for LAD. Percent mean dose reductions to the heart and LAD with DIBH are 44% (p < 0.0001) and 67% (p < 0.0001), respectively, compared to FB. The dHVIF mean dose reduction correlation is 8.1 cGy/cc for the heart and 81.6 cGy/cc for LAD (with linear trend and y intercept: 26.0 cGy for the heart, 109.1 cGy for LAD). DIBH amplitude using sternal position was [1.3(.48); .38 ~ 2.5] cm. The DIBH amplitude mean dose reduction correlation is 14 cGy/cm for the heart and 212cGy/cm for LAD (with linear trend with y intercept: 35.6 cGy for the heart, 102.4 cGy for LAD). The strong correlation of dose

  9. Imaging features of automated breast volume scanner: Correlation with molecular subtypes of breast cancer.

    PubMed

    Zheng, Feng-Yang; Lu, Qing; Huang, Bei-Jian; Xia, Han-Sheng; Yan, Li-Xia; Wang, Xi; Yuan, Wei; Wang, Wen-Ping

    2017-01-01

    To investigate the correlation between the imaging features obtained by an automated breast volume scanner (ABVS) and molecular subtypes of breast cancer. We examined 303 malignant breast tumours by ABVS for specific imaging features and by immunohistochemical analysis to determine the molecular subtype. ABVS imaging features, including retraction phenomenon, shape, margins, echogenicity, post-acoustic features, echogenic halo, and calcifications were analysed by univariate and multivariate logistic regression analyses to determine the significant predictive factors of the molecular subtypes. By univariate logistic regression analysis, the predictive factors of the Luminal-A subtype (n=128) were retraction phenomenon (odds ratio [OR]=10.188), post-acoustic shadowing (OR=5.112), and echogenic halo (OR=3.263, P<0.001). The predictive factors of the Human-epidermal-growth-factor-receptor-2-amplified subtype (n=39) were calcifications (OR=6.210), absence of retraction phenomenon (OR=4.375), non-mass lesions (OR=4.286, P<0.001), absence of echogenic halo (OR=3.851, P=0.035), and post-acoustic enhancement (OR=3.641, P=0.008). The predictors for the Triple-Negative subtype (n=47) were absence of retraction phenomenon (OR=5.884), post-acoustic enhancement (OR=5.255, P<0.001), absence of echogenic halo (OR=4.138, P=0.002), and absence of calcifications (OR=3.363, P=0.001). Predictors for the Luminal-B subtype (n=89) had a relatively lower association (OR≤2.328). By multivariate logistic regression analysis, retraction phenomenon was the strongest independent predictor for the Luminal-A subtype (OR=9.063, P<0.001) when present and for the Triple-Negative subtype (OR=4.875, P<0.001) when absent. ABVS imaging features, especially retraction phenomenon, have a strong correlation with the molecular subtypes, expanding the scope of ultrasound in identifying breast cancer subtypes with confidence. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  10. Detrended cross-correlations between returns, volatility, trading activity, and volume traded for the stock market companies

    NASA Astrophysics Data System (ADS)

    Rak, Rafał; Drożdż, Stanisław; Kwapień, Jarosław; Oświȩcimka, Paweł

    2015-11-01

    We consider a few quantities that characterize trading on a stock market in a fixed time interval: logarithmic returns, volatility, trading activity (i.e., the number of transactions), and volume traded. We search for the power-law cross-correlations among these quantities aggregated over different time units from 1 min to 10 min. Our study is based on empirical data from the American stock market consisting of tick-by-tick recordings of 31 stocks listed in Dow Jones Industrial Average during the years 2008-2011. Since all the considered quantities except the returns show strong daily patterns related to the variable trading activity in different parts of a day, which are the most evident in the autocorrelation function, we remove these patterns by detrending before we proceed further with our study. We apply the multifractal detrended cross-correlation analysis with sign preserving (MFCCA) and show that the strongest power-law cross-correlations exist between trading activity and volume traded, while the weakest ones exist (or even do not exist) between the returns and the remaining quantities. We also show that the strongest cross-correlations are carried by those parts of the signals that are characterized by large and medium variance. Our observation that the most convincing power-law cross-correlations occur between trading activity and volume traded reveals the existence of strong fractal-like coupling between these quantities.

  11. Some Foundations for Empirical Study in the Euclidean Spatial Model of Social Choice

    DTIC Science & Technology

    1991-08-01

    NPSOR-91-025 NAVAL POSTGRADUATE SCHOOL Monterey, California AD-A241 928 SOME FOUNDATIONS FOR EMPIRICAL STUDY IN THE EUCLIDEAN SPATIAL MODEL OF SOCIAL...EMPIRI AL STUDY IN THE EUCLIDEAN SPATIAL MODEL OF SOCIAL CHOICE 12 Personal Author(s) Craig A. Tovev 13a Type of Report | 3b Time Covered 14 Date of... Euclidean ; statistics, social choice; consistent estimators; spatial 19 Abstract (continue on re,’erse if aecessary and identify by block nwt er Recent

  12. Non-Euclidean geometry of twisted filament bundle packing

    PubMed Central

    Bruss, Isaac R.; Grason, Gregory M.

    2012-01-01

    Densely packed and twisted assemblies of filaments are crucial structural motifs in macroscopic materials (cables, ropes, and textiles) as well as synthetic and biological nanomaterials (fibrous proteins). We study the unique and nontrivial packing geometry of this universal material design from two perspectives. First, we show that the problem of twisted bundle packing can be mapped exactly onto the problem of disc packing on a curved surface, the geometry of which has a positive, spherical curvature close to the center of rotation and approaches the intrinsically flat geometry of a cylinder far from the bundle center. From this mapping, we find the packing of any twisted bundle is geometrically frustrated, as it makes the sixfold geometry of filament close packing impossible at the core of the fiber. This geometrical equivalence leads to a spectrum of close-packed fiber geometries, whose low symmetry (five-, four-, three-, and twofold) reflect non-Euclidean packing constraints at the bundle core. Second, we explore the ground-state structure of twisted filament assemblies formed under the influence of adhesive interactions by a computational model. Here, we find that the underlying non-Euclidean geometry of twisted fiber packing disrupts the regular lattice packing of filaments above a critical radius, proportional to the helical pitch. Above this critical radius, the ground-state packing includes the presence of between one and six excess fivefold disclinations in the cross-sectional order. PMID:22711799

  13. Is there any correlation between chronic noise-induced hearing loss and mastoid pneumatization volume? A preliminary study.

    PubMed

    Cirpar, O; Arikan, O K; Kendi, T; Gorgulu, O

    2012-01-01

    To investigate the possible association between chronic noise-induced hearing loss and the volume of mastoid pneumatization. The study involved 46 subjects employed in the press and montage department of a gun factory: 28 in the study group with noise-induced hearing loss and 18 in the control group with no hearing loss. The volume of mastoid pneumatization was measured with computed tomography. Student's t test was used in the comparison of the mastoid volumes of the study and the control groups. The intergroup evaluations showed no significant difference between the study and control group with regards to age, use of substances or ototoxic drugs, systemic diseases, use of personal hearing protectors, duration of occupational and non-occupational noise exposure was observed (P > 0.05). The mean values of mastoid pneumatization in the study and the control groups were 9717.6 mm3 and 11005.8 mm3, respectively. Although the volume of mastoid pneumatization was smaller in the study group than in the control group, this difference was not statistically significant (P > 0.05). This preliminary study showed that there was no significant correlation between mastoid pneumatization volume and chronic noise-induced hearing loss. However, this correlation could be significant in further studies with a larger number of subjects.

  14. Genetic Patterns of Correlation Among Subcortical Volumes in Humans: Results From a Magnetic Resonance Imaging Twin Study

    PubMed Central

    Eyler, Lisa T.; Prom-Wormley, Elizabeth; Fennema-Notestine, Christine; Panizzon, Matthew S.; Neale, Michael C.; Jernigan, Terry L.; Fischl, Bruce; Franz, Carol E.; Lyons, Michael J.; Stevens, Allison; Pacheco, Jennifer; Perry, Michele E.; Schmitt, J. Eric; Spitzer, Nicholas C.; Seidman, Larry J.; Thermenos, Heidi W.; Tsuang, Ming T.; Dale, Anders M.; Kremen, William S.

    2012-01-01

    Little is known about genetic influences on the volume of subcortical brain structures in adult humans, particularly whether there is regional specificity of genetic effects. Understanding patterns of genetic covariation among volumes of subcortical structures may provide insight into the development of individual differences that have consequences for cognitive and emotional behavior and neuropsychiatric disease liability. We measured the volume of 19 subcortical structures (including brain and ventricular regions) in 404 twins (110 monozygotic and 92 dizygotic pairs) from the Vietnam Era Twin Study of Aging and calculated the degree of genetic correlation among these volumes. We then examined the patterns of genetic correlation through hierarchical cluster analysis and by principal components analysis. We found that a model with four genetic factors best fit the data: a Basal Ganglia/Thalamus factor; a Ventricular factor; a Limbic factor; and a Nucleus Accumbens factor. Homologous regions from each hemisphere loaded on the same factors. The observed patterns of genetic correlation suggest the influence of multiple genetic influences. There is a genetic organization among structures which distinguishes between brain and cerebrospinal fluid spaces and between different subcortical regions. Further study is needed to understand this genetic patterning and whether it reflects influences on early development, functionally dependent patterns of growth or pruning, or regionally specific losses due to genes involved in aging, stress response, or disease. PMID:20572207

  15. Determination of correlation between backflow volume and mitral valve leaflet young modulus from two dimensional echocardiogram images

    NASA Astrophysics Data System (ADS)

    Jong, Rudiyanto P.; Osman, Kahar; Adib, M. Azrul Hisham M.

    2012-06-01

    Mitral valve prolapse without proper monitoring might lead to a severe mitral valve failure which eventually leads to a sudden death. Additional information on the mitral valve leaflet condition against the backflow volume would be an added advantage to the medical practitioner for their decision on the patients' treatment. A study on two dimensional echocardiography images has been conducted and the correlations between the backflow volume of the mitral regurgitation and mitral valve leaflet Young modulus have been obtained. Echocardiogram images were analyzed on the aspect of backflow volume percentage and mitral valve leaflet dimensions on different rates of backflow volume. Young modulus values for the mitral valve leaflet were obtained by using the principle of elastic deflection and deformation on the mitral valve leaflet. The results show that the backflow volume increased with the decrease of the mitral valve leaflet Young modulus which also indicate the condition of the mitral valve leaflet approaching failure at high backflow volumes. Mitral valve leaflet Young modulus values obtained in this study agreed with the healthy mitral valve leaflet Young modulus from the literature. This is an initial overview of the trend on the prediction of the behaviour between the fluid and the structure of the blood and the mitral valve which is extendable to a larger system of prediction on the mitral valve leaflet condition based on the available echocardiogram images.

  16. Predictability and Market Efficiency in Agricultural Futures Markets: a Perspective from Price-Volume Correlation Based on Wavelet Coherency Analysis

    NASA Astrophysics Data System (ADS)

    He, Ling-Yun; Wen, Xing-Chun

    2015-12-01

    In this paper, we use a time-frequency domain technique, namely, wavelet squared coherency, to examine the associations between the trading volumes of three agricultural futures and three different forms of these futures' daily closing prices, i.e. prices, returns and volatilities, over the past several years. These agricultural futures markets are selected from China as a typical case of the emerging countries, and from the US as a representative of the developed economies. We investigate correlations and lead-lag relationships between the trading volumes and the prices to detect the predictability and efficiency of these futures markets. The results suggest that the information contained in the trading volumes of the three agricultural futures markets in China can be applied to predict the prices or returns, while that in US has extremely weak predictive power for prices or returns. We also conduct the wavelet analysis on the relationships between the volumes and returns or volatilities to examine the existence of the two "stylized facts" proposed by Karpoff [J. M. Karpoff, The relation between price changes and trading volume: A survey, J. Financ. Quant. Anal.22(1) (1987) 109-126]. Different markets in the two countries perform differently in reproducing the two stylized facts. As the wavelet tools can decode nonlinear regularities and hidden patterns behind price-volume relationship in time-frequency space, different from the conventional econometric framework, this paper offers a new perspective into the market predictability and efficiency.

  17. The measurement of lung volumes using body plethysmography and helium dilution methods in COPD patients: a correlation and diagnosis analysis

    PubMed Central

    Tang, Yongjiang; Zhang, Mingke; Feng, Yulin; Liang, Binmiao

    2016-01-01

    Chronic obstructive pulmonary disease (COPD) is a chronic airway disease characterized by persistent airflow limitation. Moreover, lung hyperinflation evaluated by lung volumes is also the key pathophysiologic process during COPD progression. Nevertheless, there is still no preferred method to evaluate lung volumes. For this study, we recruited 170 patients with stable COPD to assess lung volumes stratified by airflow limitation severity. Lung volumes including residual volume (RV) and total lung capacity (TLC) were determined by both body plethysmography and helium dilution methods. The discrepancies between these two methods were recorded as ΔRV%pred, ΔTLC%pred, and ΔRV/TLC. We found that ΔRV%pred, ΔTLC%pred, and ΔRV/TLC increased significantly with the severity of COPD. The differences of lung capacity between these two methods were negatively correlated with FEV1%pred, and diffusing capacity for carbon monoxide (DLCO%pred). Moreover, the receiver operating characteristic (ROC) for ΔTLC%pred to distinguish severe COPD from non-severe COPD had an area under curve (AUC) of 0.886. The differences of lung volume parameters measured by body plethysmography and helium dilution methods were associated with airflow limitation and can effectively differentiate COPD severity, which may be a supportive method to assess the lung function of stable COPD patients. PMID:27876834

  18. [Coronary disease. II. Analysis of diastolic pressure-volume correlations and left ventricular elasticity in 110 patients].

    PubMed

    Strauer, B E; Bolte, H D; Heimburg, P; Riecker, G

    1975-04-01

    Left ventricular pressure-volume relationships as well as diastolic compliance were determined in 110 patients with coronary heart disease during routine right and left heart catheterization, coronary angiography and ventriculography. 1. Enddiastolic and endystolic volume of the left ventricle were increased in severe coronary heart disease dependent on the degree of coronary stenosis; left ventricular ejection fraction was consecutively reduced. 2. Left ventricular enddiastolic pressure, diastolic pressure difference and diastolic rate of pressure rise were increased in corrleation with coronary artery stenosis. In contrast, last diastolic volume inflow into the left ventricle was nearly the same in all groups. Left ventricular stiffness, expressed as dP/dV, was significantly increased dependent on the severity degree of coronary artery disease. 3. Diastolic pressure-volume relationships revealed greater steepness in coronary artery disease, significantly dependent, on the corresponding severity degree. 4. Hemodynamic measures (stroke volume, cardiac index, ejection fraction) were decreased parallel to the increased left ventricular wall stiffness. The results demonstrated decreased left ventricular compliance in coronary heart disease. There was a striking correlation between the severity degree of coronary heart disease and the decrease of left ventricular compliance. Validity and limitations of the techniques of estimating left ventricular compliance from diastolic pressures and volumes as well as the effects of a decrease of left ventricular compliance on cardiac mechanics are discussed.

  19. Structural correlates of trait anxiety: reduced thickness in medial orbitofrontal cortex accompanied by volume increase in nucleus accumbens.

    PubMed

    Kühn, Simone; Schubert, Florian; Gallinat, Jürgen

    2011-11-01

    Structural deficiencies within the medial prefrontal cortex have been shown in anxiety-related psychiatric disorders such as panic disorder, post traumatic stress disorder and obsessive compulsive disorder. In healthy subjects, trait anxiety as the individual's disposition to experience anxiety-relevant feelings or thoughts has been shown to be a risk factor for psychiatric disorders. We aimed at exploring the structural correlates of trait anxiety in normal participants. We acquired high-resolution MRI scans from 34 subjects and used FreeSurfer to obtain a measure of cortical thickness. We correlated cortical thickness with self-rated trait anxiety in a whole brain analysis. Automatic subcortical segmentations of the FreeSurfer pipeline were used to relate nucleus accumbens (NAcc) and amygdala volume to trait anxiety. Trait anxiety was negatively correlated with cortical thickness in the right medial orbitofrontal cortex (mOFC) and positively correlated with the bilateral volume of NAcc. Cortical thickness measures extracted from mOFC were negatively associated with the volume of left NAcc. Since, like in anxiety-related psychiatric disorders, in the healthy sample studied here, trait anxiety was associated with a reduction of cortical thickness in mOFC we suggest that this thinning is a structural precondition rather than a consequence of psychiatric illnesses. Copyright © 2011 Elsevier B.V. All rights reserved.

  20. Temperature and pressure correlation for volume of gas hydrates with crystal structures sI and sII

    NASA Astrophysics Data System (ADS)

    Vinš, Václav; Jäger, Andreas; Hielscher, Sebastian; Span, Roland; Hrubý, Jan; Breitkopf, Cornelia

    The temperature and pressure correlations for the volume of gas hydrates forming crystal structures sI and sII developed in previous study [Fluid Phase Equilib. 427 (2016) 268-281], focused on the modeling of pure gas hydrates relevant in CCS (carbon capture and storage), were revised and modified for the modeling of mixed hydrates in this study. A universal reference state at temperature of 273.15 K and pressure of 1 Pa is used in the new correlation. Coefficients for the thermal expansion together with the reference lattice parameter were simultaneously correlated to both the temperature data and the pressure data for the lattice parameter. A two-stage Levenberg Marquardt algorithm was employed for the parameter optimization. The pressure dependence described in terms of the bulk modulus remained unchanged compared to the original study. A constant value for the bulk modulus B0 = 10 GPa was employed for all selected hydrate formers. The new correlation is in good agreement with the experimental data over wide temperature and pressure ranges from 0 K to 293 K and from 0 to 2000 MPa, respectively. Compared to the original correlation used for the modeling of pure gas hydrates the new correlation provides significantly better agreement with the experimental data for sI hydrates. The results of the new correlation are comparable to the results of the old correlation in case of sII hydrates. In addition, the new correlation is suitable for modeling of mixed hydrates.

  1. Correlating Free-Volume Hole Distribution to the Glass Transition Temperature of Epoxy Polymers.

    PubMed

    Aramoon, Amin; Breitzman, Timothy D; Woodward, Christopher; El-Awady, Jaafar A

    2017-09-07

    A new algorithm is developed to quantify the free-volume hole distribution and its evolution in coarse-grained molecular dynamics simulations of polymeric networks. This is achieved by analyzing the geometry of the network rather than a voxelized image of the structure to accurately and efficiently find and quantify free-volume hole distributions within large scale simulations of polymer networks. The free-volume holes are quantified by fitting the largest ellipsoids and spheres in the free-volumes between polymer chains. The free-volume hole distributions calculated from this algorithm are shown to be in excellent agreement with those measured from positron annihilation lifetime spectroscopy (PALS) experiments at different temperature and pressures. Based on the results predicted using this algorithm, an evolution model is proposed for the thermal behavior of an individual free-volume hole. This model is calibrated such that the average radius of free-volumes holes mimics the one predicted from the simulations. The model is then employed to predict the glass-transition temperature of epoxy polymers with different degrees of cross-linking and lengths of prepolymers. Comparison between the predicted glass-transition temperatures and those measured from simulations or experiments implies that this model is capable of successfully predicting the glass-transition temperature of the material using only a PDF of the initial free-volume holes radii of each microstructure. This provides an effective approach for the optimized design of polymeric systems on the basis of the glass-transition temperature, degree of cross-linking, and average length of prepolymers.

  2. Correcting Correlations When Predicting Success in College. IR Applications. Volume 31

    ERIC Educational Resources Information Center

    Saupe, Joe L.; Eimers, Mardy T.

    2011-01-01

    Critics of testing for admission purposes cite the moderate correlations of admissions test scores with success in college. In response, this study applies formulas from classical measurement theory to observed correlations to correct for restricted variances in predictor and success variables. Estimates of the correlations in the population of…

  3. Three-dimensional lateral pterygoid muscle volume: MRI analyses with insertion patterns correlation.

    PubMed

    Melke, Gabriela Sobral de Figueiredo; Costa, André Luiz Ferreira; Lopes, Sérgio Lúcio Pereira de Castro; Fuziy, Acacio; Ferreira-Santos, Rívea Inês

    2016-11-01

    We evaluated lateral pterygoid muscle volume in closed and open mouth positions in association with anterior disc displacement, effusion and abnormal articular disc shape from three-dimensional reformations of MRI. A total of 24 MRI of a sample (15 females, 9 males) aged 19-64 years (37.2 years±11.4) were assessed. Segmentation and volumetric assessment of the total, upper and lower heads of the lateral pterygoid muscle were performed using free software. The upper head of the lateral pterygoid muscle had a smaller volume than the lower head at both sides, in the closed- and open-mouth positions. In the open-mouth position, individuals with a subdivided upper head, where one component was inserted in the articular disc and another in the mandibular head, displayed a significantly larger volume of the upper head compared to individuals who had a single attachment to the articular disc (p=0.0130). The lateral pterygoid muscle has different volumes in the closed- and open-mouth positions. Gender affected muscle volume, specifically the upper head component. Insertion type in the upper head also seemed to affect muscle volume.

  4. Correlation of the Peach Springs Tuff, a large-volume Miocene ignimbrite sheet in California and Arizona ( USA).

    USGS Publications Warehouse

    Glazner, A.F.; Nielson, J.E.; Howard, K.A.; Miller, D.M.

    1986-01-01

    The Peach Springs Tuff is a distinctive early Miocene ignimbrite deposit that was first recognized in western Arizona. Recent field studies and phenocryst analyses indicate that adjacent outcrops of similar tuff in the central and eastern Mojave Desert may be correlative. This proposed correlation implies that outcrops of the tuff are scattered over an area of at least 35 000 km2 from the western Colorado Plateau to Barstow, California, and that the erupted volume, allowing for posteruption crustal extension, was at least several hundred cubic kilometres. Thus, the Peach Springs Tuff may be a regional stratigraphic marker, useful for determining regional paleogeography and the time and extent of Tertiary crustal extension. -Authors

  5. Dermatoglyphic correlates of hippocampus volume: Evaluation of aberrant neurodevelopmental markers in antipsychotic-naïve schizophrenia.

    PubMed

    Kalmady, Sunil V; Shivakumar, Venkataram; Gautham, S; Arasappa, Rashmi; Jose, Dania A; Venkatasubramanian, Ganesan; Gangadhar, B N

    2015-10-30

    Schizophrenia is a disorder of aberrant neurodevelopment is marked by abnormalities in brain structure and dermatoglyphic traits. However, the link between these two (i.e. dermatoglyphic parameters and brain structure) which share ectodermal origin and common developmental window has not been explored extensively. The current study examined dermatoglyphic correlates of hippocampal volume in antipsychotic-naïve schizophrenia patients in comparison with matched healthy controls. Ridge counts and asymmetry measures for palmar inter-digital areas (a-b, b-c, c-d) were obtained using high resolution digital scans of palms from 89 schizophrenia patients [M:F=48:41] and 48 healthy controls [M:F=30:18]. Brain scans were obtained for subset of subjects including 26 antipsychotic-naïve patients [M:F=13:13] and 29 healthy controls [M:F=19:10] using 3 T-MRI. Hippocampal volume and palmar ridge counts were measured by blinded raters with good inter-rater reliability using valid methods. Directional asymmetry (DA) of b-c and bilateral hippocampal volume were significantly lower in patients than controls. Significant positive correlation was found between DA and ridge count of b-c with bilateral anterior hippocampal volume. Study demonstrates the utility of dermatoglyphic markers in identifying structural changes in the brain which may form the basis for neurodevelopmental pathogenesis in schizophrenia. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  6. Rectal planning risk volume correlation with acute and late toxicity in 3-dimensional conformal radiation therapy for prostate cancer.

    PubMed

    Dias, R S; Giordani, A J; Souhami, L; Segreto, R A; Segreto, H R C

    2011-12-01

    The purpose of this study was to evaluate rectum motion during 3-Dimensional conformal radiation therapy (3D-CRT) in prostate cancer patients, to derive a planning volume at risk (PRV) and to correlate the PRV dose-volume histograms (DVH) with treatment complications.This study was conducted in two phases. Initially, the PRV was defined prospectively in 50 consecutive prostate cancer patients (Group 1) who received a radical course of 3-D CRT. Then, the obtained PRV was used in the radiotherapy planning of these same 50 patients plus another 59 prostate cancer patients (Group 2) previously treated between 2004 and 2008. All these patients' data, including the rectum and PRV DVHs, were correlated to acute and late complications, according to the Common Toxicity Criteria (CTC) v4.0.The largest displacement occurred in the anterior axis. Long-term gastrointestinal (GI) complications grade ≥ 2 were seen in 9.2% of the cases. Factors that influenced acute GI reactions were: doses at 25% (p 5 0.011) and 40% (p 5 0.005) of the rectum volume and at 40% of the PRV (p 5 0.012). The dose at 25% of the rectum volume (p 5 0.033) and acute complications ≥ grade 2 (p 5 0.018) were prognostic factors for long-term complications. The PRV DVH did not correlate with late toxicity. The rectum showed a significant inter-fraction motion during 3D-CRT for prostate cancer. PRV dose correlated with acute gastrointestinal complications and may be a useful tool to predict and reduce their occurrence.

  7. Solving the Bethe-Salpeter Equation in Euclidean Space

    NASA Astrophysics Data System (ADS)

    Dorkin, S. M.; Kaptari, L. P.; Ciofi degli Atti, C.; Kämpfer, B.

    2011-03-01

    Different approaches to solve the spinor-spinor Bethe-Salpeter (BS) equation in Euclidean space are considered. It is argued that the complete set of Dirac matrices is the most appropriate basis to define the partial amplitudes and to solve numerically the resulting system of equations with realistic interaction kernels. Other representations can be obtained by performing proper unitary transformations. A generalization of the iteration method for finding the energy spectrum of the BS equation is discussed and examples of concrete calculations are presented. Comparison of relativistic calculations with available experimental data and with corresponding non relativistic results together with an analysis of the role of Lorentz boost effects and relativistic corrections are presented. A novel method related to the use of hyperspherical harmonics is considered for a representation of the vertex functions suitable for numerical calculations.

  8. Euclidean and Noetherian entropies in AdS space

    SciTech Connect

    Dutta, Suvankar; Gopakumar, Rajesh

    2006-08-15

    We examine the Euclidean action approach, as well as that of Wald, to the entropy of black holes in asymptotically AdS spaces. From the point of view of holography these two approaches are somewhat complementary in spirit and it is not obvious why they should give the same answer in the presence of arbitrary higher derivative gravity corrections. For the case of the AdS{sub 5} Schwarzschild black hole, we explicitly study the leading correction to the Bekenstein-Hawking entropy in the presence of a variety of higher derivative corrections studied in the literature, including the Type IIB R{sup 4} term. We find a nontrivial agreement between the two approaches in every case. Finally, we give a general way of understanding the equivalence of these two approaches.

  9. Sensor Network Localization by Eigenvector Synchronization Over the Euclidean Group

    PubMed Central

    CUCURINGU, MIHAI; LIPMAN, YARON; SINGER, AMIT

    2013-01-01

    We present a new approach to localization of sensors from noisy measurements of a subset of their Euclidean distances. Our algorithm starts by finding, embedding, and aligning uniquely realizable subsets of neighboring sensors called patches. In the noise-free case, each patch agrees with its global positioning up to an unknown rigid motion of translation, rotation, and possibly reflection. The reflections and rotations are estimated using the recently developed eigenvector synchronization algorithm, while the translations are estimated by solving an overdetermined linear system. The algorithm is scalable as the number of nodes increases and can be implemented in a distributed fashion. Extensive numerical experiments show that it compares favorably to other existing algorithms in terms of robustness to noise, sparse connectivity, and running time. While our approach is applicable to higher dimensions, in the current article, we focus on the two-dimensional case. PMID:23946700

  10. On the Euclidean version of the photon number integral

    SciTech Connect

    Ruijsenaars, S.; Stodolsky, L.

    2008-02-15

    We reconsider the Euclidean version of the photon number integral introduced by Stodolsky [Acta Phys. Pol. B 33, 2659 (2002), e-print hep-th/02053131].This integral is well defined for any smooth non-self-intersecting curve in R{sup N}. Besides studying general features of this integral (including its conformal invariance), we evaluate it explicitly for the ellipse. The result is n{sub ellipse}=({xi}{sup -1}+{xi}){pi}{sup 2}, where {xi} is the ratio of the minor and major axes. This is in agreement with the previous result n{sub circle}=2{pi}{sup 2} and also with the conjecture that the minimum value of n for any plane curve occurs for the circle.

  11. Twistor Geometry of Null Foliations in Complex Euclidean Space

    NASA Astrophysics Data System (ADS)

    Taghavi-Chabert, Arman

    2017-01-01

    We give a detailed account of the geometric correspondence between a smooth complex projective quadric hypersurface Q^n of dimension n ≥ 3, and its twistor space PT, defined to be the space of all linear subspaces of maximal dimension of Q^n. Viewing complex Euclidean space CE^n as a dense open subset of Q^n, we show how local foliations tangent to certain integrable holomorphic totally null distributions of maximal rank on CE^n can be constructed in terms of complex submanifolds of PT. The construction is illustrated by means of two examples, one involving conformal Killing spinors, the other, conformal Killing-Yano 2-forms. We focus on the odd-dimensional case, and we treat the even-dimensional case only tangentially for comparison.

  12. BPS Wilson loops in Minkowski spacetime and Euclidean space

    NASA Astrophysics Data System (ADS)

    Ouyang, Hao; Wu, Jun-Bao; Zhang, Jia-ju

    2015-12-01

    We give evidence that spacelike BPS Wilson loops do not exist in Minkowski spacetime. We show that spacelike Wilson loops in Minkowski spacetime cannot preserve any supersymmetries, in d = 4 N = 4 super Yang-Mills theory, d = 3 N = 2 super Chern-Simons-matter theory, and d = 3 N = 6 Aharony-Bergman-Jafferis-Maldacena theory. We not only show this using infinite straight lines and circles as examples, but also we give proofs for general curves. We attribute this to the conflicts of the reality conditions of the spinors. However, spacelike Wilson loops do exist in Euclidean space. There are both BPS Wilson loops along infinite straight lines and circular BPS Wilson loops. This is because the reality conditions of the spinors are lost after Wick rotation. The result is reasonable in view of the AdS/CFT correspondence.

  13. Sensor Network Localization by Eigenvector Synchronization Over the Euclidean Group.

    PubMed

    Cucuringu, Mihai; Lipman, Yaron; Singer, Amit

    2012-07-01

    We present a new approach to localization of sensors from noisy measurements of a subset of their Euclidean distances. Our algorithm starts by finding, embedding, and aligning uniquely realizable subsets of neighboring sensors called patches. In the noise-free case, each patch agrees with its global positioning up to an unknown rigid motion of translation, rotation, and possibly reflection. The reflections and rotations are estimated using the recently developed eigenvector synchronization algorithm, while the translations are estimated by solving an overdetermined linear system. The algorithm is scalable as the number of nodes increases and can be implemented in a distributed fashion. Extensive numerical experiments show that it compares favorably to other existing algorithms in terms of robustness to noise, sparse connectivity, and running time. While our approach is applicable to higher dimensions, in the current article, we focus on the two-dimensional case.

  14. Curvature-driven morphing of non-Euclidean shells

    NASA Astrophysics Data System (ADS)

    Pezzulla, Matteo; Stoop, Norbert; Jiang, Xin; Holmes, D. P.

    2017-05-01

    We investigate how thin structures change their shape in response to non-mechanical stimuli that can be interpreted as variations in the structure's natural curvature. Starting from the theory of non-Euclidean plates and shells, we derive an effective model that reduces a three-dimensional stimulus to the natural fundamental forms of the mid-surface of the structure, incorporating expansion, or growth, in the thickness. Then, we apply the model to a variety of thin bodies, from flat plates to spherical shells, obtaining excellent agreement between theory and numerics. We show how cylinders and cones can either bend more or unroll, and eventually snap and rotate. We also study the nearly isometric deformations of a spherical shell and describe how this shape change is ruled by the geometry of a spindle. As the derived results stem from a purely geometrical model, they are general and scalable.

  15. Action with Acceleration II: Euclidean Hamiltonian and Jordan Blocks

    NASA Astrophysics Data System (ADS)

    Baaquie, Belal E.

    2013-10-01

    The Euclidean action with acceleration has been analyzed in Ref. 1, and referred to henceforth as Paper I, for its Hamiltonian and path integral. In this paper, the state space of the Hamiltonian is analyzed for the case when it is pseudo-Hermitian (equivalent to a Hermitian Hamiltonian), as well as the case when it is inequivalent. The propagator is computed using both creation and destruction operators as well as the path integral. A state space calculation of the propagator shows the crucial role played by the dual state vectors that yields a result impossible to obtain from a Hermitian Hamiltonian. When it is not pseudo-Hermitian, the Hamiltonian is shown to be a direct sum of Jordan blocks.

  16. Electrophysiological Correlates of Emotional Content and Volume Level in Spoken Word Processing.

    PubMed

    Grass, Annika; Bayer, Mareike; Schacht, Annekathrin

    2016-01-01

    For visual stimuli of emotional content as pictures and written words, stimulus size has been shown to increase emotion effects in the early posterior negativity (EPN), a component of event-related potentials (ERPs) indexing attention allocation during visual sensory encoding. In the present study, we addressed the question whether this enhanced relevance of larger (visual) stimuli might generalize to the auditory domain and whether auditory emotion effects are modulated by volume. Therefore, subjects were listening to spoken words with emotional or neutral content, played at two different volume levels, while ERPs were recorded. Negative emotional content led to an increased frontal positivity and parieto-occipital negativity-a scalp distribution similar to the EPN-between ~370 and 530 ms. Importantly, this emotion-related ERP component was not modulated by differences in volume level, which impacted early auditory processing, as reflected in increased amplitudes of the N1 (80-130 ms) and P2 (130-265 ms) components as hypothesized. However, contrary to effects of stimulus size in the visual domain, volume level did not influence later ERP components. These findings indicate modality-specific and functionally independent processing triggered by emotional content of spoken words and volume level.

  17. Electrophysiological Correlates of Emotional Content and Volume Level in Spoken Word Processing

    PubMed Central

    Grass, Annika; Bayer, Mareike; Schacht, Annekathrin

    2016-01-01

    For visual stimuli of emotional content as pictures and written words, stimulus size has been shown to increase emotion effects in the early posterior negativity (EPN), a component of event-related potentials (ERPs) indexing attention allocation during visual sensory encoding. In the present study, we addressed the question whether this enhanced relevance of larger (visual) stimuli might generalize to the auditory domain and whether auditory emotion effects are modulated by volume. Therefore, subjects were listening to spoken words with emotional or neutral content, played at two different volume levels, while ERPs were recorded. Negative emotional content led to an increased frontal positivity and parieto-occipital negativity—a scalp distribution similar to the EPN—between ~370 and 530 ms. Importantly, this emotion-related ERP component was not modulated by differences in volume level, which impacted early auditory processing, as reflected in increased amplitudes of the N1 (80–130 ms) and P2 (130–265 ms) components as hypothesized. However, contrary to effects of stimulus size in the visual domain, volume level did not influence later ERP components. These findings indicate modality-specific and functionally independent processing triggered by emotional content of spoken words and volume level. PMID:27458359

  18. Squared Euclidean distance: a statistical test to evaluate plant community change

    Treesearch

    Raymond D. Ratliff; Sylvia R. Mori

    1993-01-01

    The concepts and a procedure for evaluating plant community change using the squared Euclidean distance (SED) resemblance function are described. Analyses are based on the concept that Euclidean distances constitute a sample from a population of distances between sampling units (SUs) for a specific number of times and SUs. With different times, the distances will be...

  19. A Case Example of Insect Gymnastics: How Is Non-Euclidean Geometry Learned?

    ERIC Educational Resources Information Center

    Junius, Premalatha

    2008-01-01

    The focus of the article is on the complex cognitive process involved in learning the concept of "straightness" in Non-Euclidean geometry. Learning new material is viewed through a conflict resolution framework, as a student questions familiar assumptions understood in Euclidean geometry. A case study reveals how mathematization of the straight…

  20. Modelflow Estimates of Stroke Volume Do Not Correlate With Doppler Ultrasound Estimates During Upright Posture

    NASA Technical Reports Server (NTRS)

    Ferguson, Connor R.; Lee, Stuart M. C.; Stenger, Michael B.; Platts, Steven H.; Laurie, Steven S.

    2014-01-01

    Orthostatic intolerance affects 60-80% of astronauts returning from long-duration missions, representing a significant risk to completing mission-critical tasks. While likely multifactorial, a reduction in stroke volume (SV) represents one factor contributing to orthostatic intolerance during stand and head up tilt (HUT) tests. Current measures of SV during stand or HUT tests use Doppler ultrasound and require a trained operator and specialized equipment, restricting its use in the field. BeatScope (Finapres Medical Systems BV, The Netherlands) uses a modelflow algorithm to estimate SV from continuous blood pressure waveforms in supine subjects; however, evidence supporting the use of Modelflow to estimate SV in subjects completing stand or HUT tests remain scarce. Furthermore, because the blood pressure device is held extended at heart level during HUT tests, but allowed to rest at the side during stand tests, changes in the finger arterial pressure waveform resulting from arm positioning could alter modelflow estimated SV. The purpose of this project was to compare Doppler ultrasound and BeatScope estimations of SV to determine if BeatScope can be used during stand or HUT tests. Finger photoplethysmography was used to acquire arterial pressure waveforms corrected for hydrostatic finger-to-heart height using the Finometer (FM) and Portapres (PP) arterial pressure devices in 10 subjects (5 men and 5 women) during a stand test while simultaneous estimates of SV were collected using Doppler ultrasound. Measures were made after 5 minutes of supine rest and while subjects stood for 5 minutes. Next, SV estimates were reacquired while each arm was independently raised to heart level, a position similar to tilt testing. Supine SV estimates were not significantly different between all three devices (FM: 68+/-20, PP: 71+/-21, US: 73+/-21 ml/beat). Upon standing, the change in SV estimated by FM (-18+/-8 ml) was not different from PP (-21+/-12), but both were significantly

  1. Onboard utilization of ground control points for image correction. Volume 4: Correlation analysis software design

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The software utilized for image correction accuracy measurement is described. The correlation analysis program is written to allow the user various tools to analyze different correlation algorithms. The algorithms were tested using LANDSAT imagery in two different spectral bands. Three classification algorithms are implemented.

  2. Creatine Kinase Activity Weakly Correlates to Volume Completed Following Upper Body Resistance Exercise

    ERIC Educational Resources Information Center

    Machado, Marco; Willardson, Jeffrey M.; Silva, Dailson P.; Frigulha, Italo C.; Koch, Alexander J.; Souza, Sergio C.

    2012-01-01

    In the current study, we examined the relationship between serum creatine kinase (CK) activity following upper body resistance exercise with a 1- or 3-min rest between sets. Twenty men performed two sessions, each consisting of four sets with a 10-repetition maximum load. The results demonstrated significantly greater volume for the 3-min…

  3. Cardiovascular correlates of platelet count and volume in the Framingham Heart Study

    PubMed Central

    Sloan, Arielle; Gona, Philimon; Johnson, Andrew

    2015-01-01

    Purpose Platelet count and volume are inexpensive, routinely-assayed biomarkers associated with cardiovascular health, but specific relationships among platelet indices, cardiovascular risk factors, and disease warrant further investigation. The purpose of this study was to understand associations among platelet count, volume, and 20 cardiovascular health-related variables in the Framingham Heart Study. Methods Cross-sectional analyses were performed on platelet count and volume associations with cardiovascular health indicators in three Framingham Heart Study cohorts (Original n=964, Offspring n=2,699, and Third Generation n=2,419) using multivariable linear regression analysis. Time-to-event analysis was employed for cardiovascular disease-related event incidences using Kaplan-Meier plots and Cox proportional hazards regression adjusted for age and gender. Results Results were concordant with the hypothesis that higher platelet counts are associated with less favorable cardiovascular risk profiles, although mean platelet volume associations were weaker. In our analysis, increased platelet count across FHS cohorts was consistently associated with smoking, triglycerides, LDL and total cholesterol levels. Some associations with platelet count appeared gender-dependent. Conclusions Significant associations of common blood platelet measurements are observed with gender and cardiovascular risk factors, namely smoking and lipids. Research is warranted to confirm these relationships in other cohorts, evaluate differences by ethnicity and examine longitudinal effects on disease risk. PMID:25771288

  4. Creatine Kinase Activity Weakly Correlates to Volume Completed Following Upper Body Resistance Exercise

    ERIC Educational Resources Information Center

    Machado, Marco; Willardson, Jeffrey M.; Silva, Dailson P.; Frigulha, Italo C.; Koch, Alexander J.; Souza, Sergio C.

    2012-01-01

    In the current study, we examined the relationship between serum creatine kinase (CK) activity following upper body resistance exercise with a 1- or 3-min rest between sets. Twenty men performed two sessions, each consisting of four sets with a 10-repetition maximum load. The results demonstrated significantly greater volume for the 3-min…

  5. Neural correlates of the 'good life': eudaimonic well-being is associated with insular cortex volume.

    PubMed

    Lewis, Gary J; Kanai, Ryota; Rees, Geraint; Bates, Timothy C

    2014-05-01

    Eudaimonic well-being reflects traits concerned with personal growth, self-acceptance, purpose in life and autonomy (among others) and is a substantial predictor of life events, including health. Although interest in the aetiology of eudaimonic well-being has blossomed in recent years, little is known of the underlying neural substrates of this construct. To address this gap in our knowledge, here we examined whether regional gray matter (GM) volume was associated with eudaimonic well-being. Structural magnetic resonance images from 70 young, healthy adults who also completed Ryff's 42-item measure of the six core facets of eudaimonia, were analysed with voxel-based morphometry techniques. We found that eudaimonic well-being was positively associated with right insular cortex GM volume. This association was also reflected in three of the sub-scales of eudaimonia: personal growth, positive relations and purpose in life. Positive relations also showed a significant association with left insula volume. No other significant associations were observed, although personal growth was marginally associated with left insula, and purpose in life exhibited a marginally significant negative association with middle temporal gyrus GM volume. These findings are the first to our knowledge linking eudaimonic well-being with regional brain structure.

  6. Geostatistical analysis of groundwater level using Euclidean and non-Euclidean distance metrics and variable variogram fitting criteria

    NASA Astrophysics Data System (ADS)

    Theodoridou, Panagiota G.; Karatzas, George P.; Varouchakis, Emmanouil A.; Corzo Perez, Gerald A.

    2015-04-01

    Groundwater level is an important information in hydrological modelling. Geostatistical methods are often employed to map the free surface of an aquifer. In geostatistical analysis using Kriging techniques the selection of the optimal variogram model is very important for the optimal method performance. This work compares three different criteria, the least squares sum method, the Akaike Information Criterion and the Cressie's Indicator, to assess the theoretical variogram that fits to the experimental one and investigates the impact on the prediction results. Moreover, five different distance functions (Euclidean, Minkowski, Manhattan, Canberra, and Bray-Curtis) are applied to calculate the distance between observations that affects both the variogram calculation and the Kriging estimator. Cross validation analysis in terms of Ordinary Kriging is applied by using sequentially a different distance metric and the above three variogram fitting criteria. The spatial dependence of the observations in the tested dataset is studied by fitting classical variogram models and the Matérn model. The proposed comparison analysis performed for a data set of two hundred fifty hydraulic head measurements distributed over an alluvial aquifer that covers an area of 210 km2. The study area is located in the Prefecture of Drama, which belongs to the Water District of East Macedonia (Greece). This area was selected in terms of hydro-geological data availability and geological homogeneity. The analysis showed that a combination of the Akaike information Criterion for the variogram fitting assessment and the Brays-Curtis distance metric provided the most accurate cross-validation results. The Power-law variogram model provided the best fit to the experimental data. The aforementioned approach for the specific dataset in terms of the Ordinary Kriging method improves the prediction efficiency in comparison to the classical Euclidean distance metric. Therefore, maps of the spatial

  7. Quality of life in patients treated by adjuvant radiotherapy for endometrial and cervical cancers: correlation with dose-volume parameters.

    PubMed

    Pisani, C; Deantonio, L; Surico, D; Brambilla, M; Galla, A; Ferrara, E; Masini, L; Gambaro, G; Surico, N; Krengli, M

    2016-09-01

    Modern multidisciplinary cancer treatments aim at obtaining minimal influence on patients' quality of life (QoL). The purpose of this study was to assess QoL and correlate it with dose-volume parameters of organ at risks (OARs) in patients who received adjuvant radiotherapy for endometrial and cervical cancers. We administered the EORTC QLQ-C30 and EN24 or CX24 questionnaires to 124 patients, 100 with endometrial cancer and 24 with cervical cancer treated with postoperative radiotherapy ± chemotherapy in regular follow-up. Bladder function, fecal incontinence or urgency and sexual functioning were investigated and correlated with dose-volume parameters of OAR by multiple linear regression analysis. This correlation was assessed by R (2) value. QoL was very high in the majority of patients (82.3 % of patients). Few patients referred urinary incontinence (3.2 %) or abdominal discomfort of high grade (4.0 %). We found a significant correlation between bladder V40, i.e., absolute percentage of bladder volume that received a dose of 40 Gy, and global health status (p < 0.05, R (2) = 0.17), urinary urgency (p < 0.05, R (2) = 0.24), urinary incontinence (p < 0.05, R (2) = 0.23) and dyspareunia (p < 0.05, R (2) = 0.04). We found also a correlation between global health status and mean dose to vagina (p < 0.05, R (2) = 0.17) and between maximum dose to lumbo-sacral plexus and abdominal pain (p < 0.05, R (2) = 0.07). Women treated with surgery and adjuvant radiotherapy for endometrial and cervical cancers have good QoL with minimal limitations of daily activities. QoL was correlated with dose-volume parameters such as bladder V40, mean dose to vagina, maximum dose to trigone and LSP.

  8. Mapping soil deformation around plant roots using in vivo 4D X-ray Computed Tomography and Digital Volume Correlation.

    PubMed

    Keyes, S D; Gillard, F; Soper, N; Mavrogordato, M N; Sinclair, I; Roose, T

    2016-06-14

    The mechanical impedance of soils inhibits the growth of plant roots, often being the most significant physical limitation to root system development. Non-invasive imaging techniques have recently been used to investigate the development of root system architecture over time, but the relationship with soil deformation is usually neglected. Correlative mapping approaches parameterised using 2D and 3D image data have recently gained prominence for quantifying physical deformation in composite materials including fibre-reinforced polymers and trabecular bone. Digital Image Correlation (DIC) and Digital Volume Correlation (DVC) are computational techniques which use the inherent material texture of surfaces and volumes, captured using imaging techniques, to map full-field deformation components in samples during physical loading. Here we develop an experimental assay and methodology for four-dimensional, in vivo X-ray Computed Tomography (XCT) and apply a Digital Volume Correlation (DVC) approach to the data to quantify deformation. The method is validated for a field-derived soil under conditions of uniaxial compression, and a calibration study is used to quantify thresholds of displacement and strain measurement. The validated and calibrated approach is then demonstrated for an in vivo test case in which an extending maize root in field-derived soil was imaged hourly using XCT over a growth period of 19h. This allowed full-field soil deformation data and 3D root tip dynamics to be quantified in parallel for the first time. This fusion of methods paves the way for comparative studies of contrasting soils and plant genotypes, improving our understanding of the fundamental mechanical processes which influence root system development. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. The influence of correlated protein-water volume fluctuations on the apparent compressibility of proteins determined by ultrasonic velocimetry.

    PubMed

    Pfeiffer, Helge; Heremans, Karel; Wevers, Martine

    2008-11-01

    The elasticity of proteins, expressed by the compressibility, is potentially one of the most important properties of proteins because of the close relationship with its functionality. The compressibility of solutions can be determined by measurements of sound velocity and density. These quantities are related by the Newton-Laplace equation. In order to interpret the apparent compressibility of solutes in highly dilute solutions, it is required to consider the relation between compressibility and sound velocity of the solution using an appropriate reference system. The classical approach usually gives too small values for the apparent compressibility when compared with other methods. We show that the difference can partially be explained if the correlated volume fluctuations of the solvent are taken into consideration. A special attention is given to the compressibility of proteins. Finally, the present paper is not intended to replace established approaches, but it wants to create awareness that the classical mixing rules refer to ideal gasses assuming uncorrelated volume fluctuations and that a considerable part of the hydration effects could be explained by correlated volume fluctuations.

  10. Increased gray matter volume of left pars opercularis in male orchestral musicians correlate positively with years of musical performance.

    PubMed

    Abdul-Kareem, Ihssan A; Stancak, Andrej; Parkes, Laura M; Sluming, Vanessa

    2011-01-01

    To compare manual volumetry of gray matter (GM) / white matter (WM) of Broca's area subparts: pars opercularis (POP) and pars triangularis (PTR) in both hemispheres between musicians and nonmusician, as it has been shown that these regions are crucial for musical abilities. A previous voxel-based morphometric (VBM) study conducted in our laboratory reported increased GM density in Broca's area of left hemisphere in male orchestral musicians. Functional segregation of POP/PTR justified separate volumetric analysis of these parts. We used the same cohort for the VBM study. Manual morphometry (stereology) was used to compare volumes between 26/26 right-handed orchestral musicians/nonmusicians. As expected, musicians showed significantly increased GM volume in the Broca's area, specifically in the left POP. No significant results were detected in right POP, left/right PTR GM volumes, and WM volumes for all regions. Results were positively correlated with years of musical performance (r = 0.7, P = 0.0001). This result corroborates the VBM study and is in line with the hypothesis of critical involvement of POP in hearing-action integration being an integral component of frontoparietotemporal mirror neuron network. We hypothesize that increased size of musicians' left POP represent use-dependent structural adaptation in response to intensive audiomotor skill acquisition. Copyright © 2010 Wiley-Liss, Inc.

  11. Spatial resolution and measurement uncertainty of strains in bone and bone-cement interface using digital volume correlation.

    PubMed

    Zhu, Ming-Liang; Zhang, Qing-Hang; Lupton, Colin; Tong, Jie

    2016-04-01

    The measurement uncertainty of strains has been assessed in a bone analogue (sawbone), bovine trabecular bone and bone-cement interface specimens under zero load using the Digital Volume Correlation (DVC) method. The effects of sub-volume size, sample constraint and preload on the measured strain uncertainty have been examined. There is generally a trade-off between the measurement uncertainty and the spatial resolution. Suitable sub-volume sizes have been be selected based on a compromise between the measurement uncertainty and the spatial resolution of the cases considered. A ratio of sub-volume size to a microstructure characteristic (Tb.Sp) was introduced to reflect a suitable spatial resolution, and the measurement uncertainty associated was assessed. Specifically, ratios between 1.6 and 4 appear to give rise to standard deviations in the measured strains between 166 and 620 με in all the cases considered, which would seem to suffice for strain analysis in pre as well as post yield loading regimes. A microscale finite element (μFE) model was built from the CT images of the sawbone, and the results from the μFE model and a continuum FE model were compared with those from the DVC. The strain results were found to differ significantly between the two methods at tissue level, consistent in trend with the results found in human bones, indicating mainly a limitation of the current DVC method in mapping strains at this level. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Effects of excluded volume and correlated molecular orientations on Förster resonance energy transfer in liquid water

    SciTech Connect

    Yang, Mino

    2014-04-14

    Förster theory for the survival probability of excited chromophores is generalized to include the effects of excluded volume and orientation correlation in the molecular distribution. An analytical expression for survival probability was derived and written in terms of a few simple elementary functions. Because of the excluded volume, the survival probability exhibits exponential decay at early times and stretched exponential decay at later times. Experimental schemes to determine the size of the molecular excluded volume are suggested. With the present generalization of theory, we analyzed vibrational resonance energy transfer kinetics in neat water. Excluded volume effects prove to be important and slow down the kinetics at early times. The majority of intermolecular resonance energy transfer was found to occur with exponential kinetics, as opposed to the stretched exponential behavior predicted by Förster theory. Quantum yields of intra-molecular vibrational relaxation, intra-, and intermolecular energy transfer were calculated to be 0.413, 0.167, and 0.420, respectively.

  13. Optimization of wavelet filters to improve recognition accuracy of a volume holographic correlator

    NASA Astrophysics Data System (ADS)

    Feng, Wenyi; Yan, Yingbai; Huang, Gaogui; Jin, Guofan; Wu, Minxian

    1999-10-01

    The concept of the associative storage in a photorefractive material offers suitable methods to design a multichannel correlator for image identification. Wavelet transform is introduced to improve recognition accuracy of the system, which provides a sharper peak and lower sidelobes than the conventional correlation. The recognition accuracy of the system is significantly affected by the choice of wavelet function and its parameters. A neural network is proposed to optimize parameters of the wavelet filters to improve recognition performance of the system. The object function for optimization is to maximize the difference of correlation outputs among different categories and minimize the variation of correlation outputs in a same category. Simulation and experimental results are given to testify the effect of optimization. Its application in human face recognition is studied. The results show that it is attractive to use neural network to refine parameters of filters.

  14. SU-E-T-72: A Retrospective Correlation Analysis On Dose-Volume Control Points and Treatment Outcomes

    SciTech Connect

    Roy, A; Nohadani, O; Refaat, T; Bacchus, I; Cutright, D; Sathiaseelan, V; Mittal, B

    2015-06-15

    Purpose: To quantify correlation between dose-volume control points and treatment outcomes. Specifically, two outcomes are analyzed: occurrence of radiation induced dysphagia and target complications. The results inform the treatment planning process when competing dose-volume criteria requires relaxations. Methods: 32 patients, treated with whole-field sequential intensity modulated radiation therapy during 2009–2010 period, are considered for this study. Acute dysphagia that is categorized into 3 grades is observed on all patients. 3 patients are observed in grade 1, 17 patients in grade 2, and 12 patients in grade 3. Ordinal logistic regression is employed to establish correlations between grades of dysphagia and dose to cervico-thoracic esophagus. Particularly, minimum (Dmin), mean (Dmean), and maximum (Dmax) dose control points are analyzed. Additionally, target complication, which includes local-regional recurrence and/or distant metastasis, is observed on 4 patients. Binary logistic regression is used to quantify correlation between target complication and four dose control points. Namely, ICRU recommended dose control points, D2, D50, D95, and D98 are analyzed. Results: For correlation with dysphagia, Dmin on cervico-thoracic esophagus is statistically significant (p-value = 0.005). Additionally, Dmean on cervico-thoracic esophagus is also significant in association with dysphagia (p-value = 0.012). However, no correlation was observed between Dmax and dysphagia (p-value = 0.263). For target complications, D50 on the target is a statistically significant dose control point (p-value = 0.032). No correlations were observed between treatment complications and D2 (p-value = 0.866), D95 (p-value = 0.750), and D98 (p-value = 0.710) on the target. Conclusion: Significant correlations are observed between radiation induced dysphagia and Dmean (and Dmin) to cervico-thoracic esophagus. Additionally, correlation between target complications and median dose to target

  15. Mean Platelet Volume Reflect Hematopoietic Potency and Correlated Blood Group O in Cord Blood from Healthy Newborn

    PubMed Central

    Lee, Hye Ryun; Park, Jeong Su; Shin, Sue; Roh, Eun Youn; Yoon, Jong Hyun; Song, Eun Young; Kim, Byung Jae; Chang, Ju Young

    2013-01-01

    We evaluated the relationship between mean platelet volume (MPV) and characteristics of 10,577 cord blood (CB) units in a public CB bank in Korea. Blood group O has the highest MPV (P = 0.002). MPV correlated with CB volume (r = 0.121), Hb (r = 0.377), WBC (r = 0.111), TNCs (r = 0.110), CD34+ cell (r = 0.174), CD34+ cells/TNCs (r = 0.157), gestational age (r = −0.102), and birth weight (r = 0.023); (P < 0.001 in all). MPV may be one of the useful decision parameters of process priority in CB bank. PMID:23607095

  16. Mechanical durability of polymeric coatings studied by positron annihilation spectroscopy: correlation between cyclic loading and free volumes

    NASA Astrophysics Data System (ADS)

    Chen, H.; Peng, Q.; Huang, Y. Y.; Zhang, R.; Mallon, P. E.; Zhang, J.; Li, Y.; Wu, Y.; Richardson, J. R.; Sandreczki, T. C.; Jean, Y. C.; Suzuki, R.; Ohdaira, T.

    2002-06-01

    The mechanical durability of seven commercially polymeric coatings is investigated using slow positron beam techniques to monitor changes in sub-nanometer defects during the process of cyclic loading. Doppler broadened energy spectra and positron annihilation lifetime (PAL) measurements were performed as a function of the slow positron energy at different periods of cycling loading. The positron annihilation dada show that both S-defect parameter and o-positronium (Ps) lifetime decrease as the loading cycle increases. The results indicate a loss of free volumes due to the loss of mechanical durability by cyclic loading. A direct correlation between the loss of S-defect parameter and the period of loading cycle is observed. This is interpreted as that durability of polymeric coatings is controlled by the atomic level free volumes. It is shown that the slow positron beam is a very successful probe in detecting the very early stages of coating degradation due to mechanical processes.

  17. Instanton-like self-dual solution to lattice Euclidean Gravity: Difference from Eguchi-Hanson solution to continuous gravity

    NASA Astrophysics Data System (ADS)

    Vergeles, S. N.

    2016-10-01

    The self-dual solution to lattice Euclidean gravity is constructed. In contrast to the well-known Eguchi-Hanson solution to continuous Euclidean Gravity, the lattice solution is asymptotically globally Euclidean, i.e., the boundary of the space as r → ∞ is S 3 = SU(2)

  18. A note on the possible existence of an instanton-like self-dual solution to lattice Euclidean gravity

    NASA Astrophysics Data System (ADS)

    Vergeles, S. N.

    2017-02-01

    The self-dual solution to lattice Euclidean gravity is constructed. In contrast to the well known Eguchi-Hanson solution to continuous Euclidean Gravity, the lattice solution is asymptotically globally Euclidean, i.e., the boundary of the space as r -→ ∞ is S 3 = SU(2).

  19. Histopathological correlation of (11)C-choline PET scans for target volume definition in radical prostate radiotherapy.

    PubMed

    Chang, Joe H; Joon, Daryl Lim; Lee, Sze Ting; Gong, Sylvia J; Scott, Andrew M; Davis, Ian D; Clouston, David; Bolton, Damien; Hamilton, Christopher S; Khoo, Vincent

    2011-05-01

    To evaluate the accuracy of (11)C-choline PET scans in defining dominant intraprostatic lesions (DILs) for radiotherapy target volume definition. Eight men with prostate cancer who had (11)C-choline PET scans prior to radical prostatectomy were studied. Several methods were used to contour the DIL on the PET scans: visual, PET Edge, Region Grow, absolute standardised uptake value (SUV) thresholds and percentage of maximum SUV thresholds. Prostatectomy specimens were sliced in the transverse plane and DILs were delineated on these by a pathologist. These were then compared with the PET scans. The accuracy of correlation was assessed by the Dice similarity coefficient (DSC) and the Youden index. The contouring method resulting in both the highest DSC and the highest Youden index was 60% of the maximum SUV (SUV(60%)), with values of 0.64 and 0.51, respectively. However SUV(60%) was not statistically significantly better than all of the other methods by either measure. Although not statistically significant, SUV(60%) resulted in the best correlation between (11)C-choline PET and pathology amongst all the methods studied. The degree of correlation shown here is consistent with previous studies that have justified using imaging for DIL radiotherapy target volume definition. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  20. Left atrial minimum volume and reservoir function as correlates of left ventricular diastolic function: impact of left ventricular systolic function

    PubMed Central

    Russo, Cesare; Jin, Zhezhen; Homma, Shunichi; Rundek, Tatjana; Elkind, Mitchell S V; Sacco, Ralph L; Di Tullio, Marco R

    2012-01-01

    Objective Left atrial (LA) maximum volume (LAVmax) is an indicator of left ventricular (LV) diastolic function. However, LAVmax is also influenced by systolic events, whereas the LA minimum volume (LAVmin) is directly exposed to LV pressure. The authors hypothesised that LAVmin may be a better correlate of LV diastolic function than LAVmax. Design Cross-sectional. Setting University hospital. Patients 357 participants from a community-based cohort study. Methods LA volumes and reservoir function, measured as total LA emptying volume (LAEV) and LA emptying fraction (LAEF), were assessed by real-time three-dimensional echocardiography. LV diastolic function was assessed by trans-mitral early (E) and late (A) Doppler velocities and mitral early diastolic velocity by tissue-Doppler (e′). LV systolic function was assessed by LV ejection fraction (LVEF) and global longitudinal strain (GLS) by speckle-tracking. Results LAVmin significantly increased with worsening diastolic dysfunction (p<0.001), whereas the increase in LAVmax was less pronounced (p=0.07). LAEV and LAEF decreased with worsening diastolic dysfunction (both p<0.001). In linear regressions, LAVmin and LAVmax were significant predictors of E/e′, with higher parameter estimates for LAVmin. In multivariate models, LAVmin resulted strongly associated with E/e′ (β=0.45, p<0.001), whereas LAVmax was not (β=− 0.16, p=0.08). LA reservoir function was better associated with GLS than LVEF. In multivariate analyses, GLS was significantly associated with LAVmax (β=− 0.15, p=0.002), LAEV (β=−0.37, p<0.001) and LAEF (β=−0.28, p<0.001) but not with LAVmin. Conclusions LAVmin is a better correlate of LV diastolic function than LAVmax. The impact of LV longitudinal systolic function on LA reservoir function might explain the weaker relation between LAVmax and LV diastolic function. PMID:22543839

  1. Three dimensional left atrial volume index is correlated with P wave dispersion in elderly patients with sinus rhythm.

    PubMed

    Ozyigit, Tolga; Kocas, Onur; Karadag, Berrin; Ozben, Beste

    2016-03-01

    P wave dispersion is a noninvasive electrocardiographic predictor for atrial fibrillation. The aim of the study was to explore relation between left atrial volume index assessed by 3-dimensional echocardiography and P wave dispersion in elderly patients. Seventy-three consecutive patients over the age of 65 (mean age: 75 ± 7 years, 17 men) were included. P wave dispersion is calculated as the difference between maximum and minimum P wave durations. Left atrial volume index was measured by both 2-dimensional and 3-dimensional echocardiography and categorized as normal (≤ 34 mL/m(2)) or increased (mild, 35-41 mL/m(2); moderate, 42-48 mL/m(2); severe, ≥ 49 mL/m(2)). Thirty-one patients had normal left atrium while 24 patients had mildly enlarged, nine had moderately enlarged, and nine had severely enlarged left atrium. Prolongation of P wave dispersion was more prevalent in patients with dilated left atrium. P wave dispersion was significantly correlated with both 2-dimensional (r = 0.600, p < 0.001) and 3-dimensional left atrial volume index (r = 0.688, p < 0.001). Both left atrial volume indexes were associated with prolonged P wave dispersion when adjusted for age, sex, presence of hypertension, and left ventricular mass index. Receiver-operator characteristic (ROC) analysis revealed that a 3-dimensional left atrial volume index ≥ 25 mL/m(2) separated patients with prolonged P wave dispersion with a sensitivity of 82.2 %, specificity of 67.9 %, positive predictive value of 80.4 %, and negative predictive value of 70.4 %. In elderly patients, 3-dimensional left atrial volume index showed a better correlation with P wave dispersion and might be helpful in discriminating patients with prolonged P wave dispersion, who might be prone to atrial fibrillation.

  2. Digital volume correlation can be used to estimate local strains in natural and augmented vertebrae: An organ-level study.

    PubMed

    Palanca, Marco; Cristofolini, Luca; Dall'Ara, Enrico; Curto, Marco; Innocente, Federica; Danesi, Valentina; Tozzi, Gianluca

    2016-12-08

    Digital Volume Correlation (DVC) has become popular for measuring the strain distribution inside bone structures. A number of methodological questions are still open: the reliability of DVC to investigate augmented bone tissue, the variability of the errors between different specimens of the same type, the distribution of measurement errors inside a bone, and the possible presence of preferential directions. To address these issues, five augmented and five natural porcine vertebrae were subjected to repeated zero-strain micro-CT scan (39μm voxel size). The acquired images were processed with two independent DVC approaches (a local and a global one), considering different computation sub-volume sizes, in order to assess the strain measurement uncertainties. The systematic errors generally ranged within ±100 microstrain and did not depend on the computational sub-volume. The random error was higher than 1000 microstrain for the smallest sub-volume and rapidly decreased: with a sub-volume of 48 voxels the random errors were typically within 200 microstrain for both DVC approaches. While these trends were rather consistent within the sample, two individual specimens had unpredictably larger errors. For this reason, a zero-strain check on each specimen should always be performed before any in-situ micro-CT testing campaign. This study clearly shows that, when sufficient care is dedicated to preliminary methodological work, different DVC computation approaches allow measuring the strain with a reduced overall error (approximately 200 microstrain). Therefore, DVC is a viable technique to investigate strain in the elastic regime in natural and augmented bones.

  3. The correlation between the Trendelenburg position and the stroke volume variation

    PubMed Central

    Lee, Sang Eun; Lee, Hong Sik; Chae, Young Keun; Lee, Yong Kyung; Kang, Yoo; Je, Ui Jin

    2014-01-01

    Background The stroke volume variation (SVV), based on lung-heart interaction during mechanical ventilation, is a useful dynamic parameter for fluid responsiveness. However, it is affected by many factors. The aim of this study was to evaluate the effects of SVV on Trendelenburg (T) and reverse Trendelenburg (RT) position and to further elaborate on the patterns of the SVV with position. Methods Forty-two patients undergoing elective surgery were enrolled in this study. Fifteen minutes after standardized induction of anesthesia with propofol, fentanyl, and rocuronium with volume controlled ventilation (tidal volume of 8 ml/kg of ideal body weight, inspiration : expiration ratio of 1 : 2, and respiratory rate of 10-13 breaths/min), the patients underwent posture changes as follows: supine, T position at slopes of operating table of -5°, -10°, and -15°, and RT position at slopes of operating table of 5°, 10°, and 15°. At each point, SVV, cardiac output (CO), peak airway pressure (PAP), mean blood pressure, and heart rate (HR) were recorded. Results The SVV was significant decreased with decreased slopes of operating table in T position, and increased with increased slopes of operating table in RT position (P = 0.000). Schematically, it was increased by 1% when the slope of operating table was increased by 5°. But, the CO and PAP were significant increased with decreased slopes of operating table in T position, and decreased with increased slopes of operating table in RT position (P = 0.045, 0.027). Conclusions SVV is subjected to the posture, and we should take these findings into account on reading SVV for fluid therapy. PMID:25558337

  4. Euclidean supersymmetric solutions with the self-dual Weyl tensor

    NASA Astrophysics Data System (ADS)

    Nozawa, Masato

    2017-07-01

    We explore the Euclidean supersymmetric solutions admitting the self-dual gauge field in the framework of N = 2 minimal gauged supergravity in four dimensions. According to the classification scheme utilizing the spinorial geometry or the bilinears of Killing spinors, the general solution preserves one quarter of supersymmetry and is described by the Przanowski-Tod class with the self-dual Weyl tensor. We demonstrate that there exists an additional Killing spinor, provided the Przanowski-Tod metric admits a Killing vector that commutes with the principal one. The proof proceeds by recasting the metric into another Przanowski-Tod form. This formalism enables us to show that the self-dual Reissner-Nordström-Taub-NUT-AdS metric possesses a second Killing spinor, which has been missed over many years. We also address the supersymmetry when the Przanowski-Tod space is conformal to each of the self-dual ambi-toric Kähler metrics. It turns out that three classes of solutions are all reduced to the self-dual Carter family, by virtue of the nondegenerate Killing-Yano tensor.

  5. Aspects of type IIB theory on asymptotically locally Euclidean spaces

    NASA Astrophysics Data System (ADS)

    Johnson, Clifford V.; Myers, Robert C.

    1997-05-01

    D-brane technology and strong/weak coupling duality supplement traditional orbifold techniques by making certain background geometries more accessible. In this spirit, we consider some of the geometric properties of the type IIB theory on R6×M, where M is an ``asymptotically locally Euclidean'' (ALE) gravitational instanton. Given the self-duality of the theory, we can extract the geometry (both singular and resolved) seen by the weakly coupled IIB string by studying the physics of a D1-brane probe. The construction is both amusing and instructive, as the physics of the probe completely captures the mathematics of the construction of ALE instantons via ``hyper-Kähler quotients,'' as presented by Kronheimer. This relation has been noted by Douglas and Moore for the A series. We extend the explicit construction to the case of the D and E series-uncovering a quite beautiful structure-and highlight how all of the elements of the mathematical construction find their counterparts in the physics of the type IIB D-string. We discuss the explicit ALE metrics which may be obtained using these techniques, and comment on the role duality plays in relating gauged linear σ models to conformal field theories.

  6. Heritability and genetic correlations for volume, foxtails, and other characteristics of Caribbean pine in Puerto Rico

    Treesearch

    F. Thomas Ledig; J.L. Whitmore

    1981-01-01

    Caribbean pine is an important exotic being bred throughout the tropics, but published estimates are lacking for heritability of economically important traits and the genetic correlations between them. Based on a Puerto Rican trial of 16 open-pollinated parents of var. hondurensis selected in Belize, heritabilities for a number of characteristics...

  7. Putamen Volume is Negatively Correlated with the Ability to Recognize Fearful Facial Expressions.

    PubMed

    Uono, Shota; Sato, Wataru; Kochiyama, Takanori; Kubota, Yasutaka; Sawada, Reiko; Yoshimura, Sayaka; Toichi, Motomi

    2017-07-26

    Findings of previous functional magnetic resonance imaging (MRI) and neuropsychological studies have suggested that specific aspects of the basal ganglia, particularly the putamen, are involved in the recognition of emotional facial expressions. However, it remains unknown whether variations in putamen structure reflect individual differences in the ability to recognize facial expressions. Thus, the present study assessed the putamen volumes and shapes of 50 healthy Japanese adults using structural MRI scans and evaluated the ability of participants to recognize facial expressions associated with six basic emotions: anger, disgust, fear, happiness, sadness, and surprise. The volume of the bilateral putamen was negatively associated with the recognition of fearful faces, and the local shapes of both the anterior and posterior subregions of the bilateral putamen, which are thought to support cognitive/affective and motor processing, respectively, exhibited similar negative relationships with the recognition of fearful expressions. These results suggest that individual differences in putamen structure can predict the ability to recognize fearful facial expressions in others. Additionally, these findings indicate that cognitive/affective and motor processing underlie this process.

  8. Correlation between bone marrow dose volumes and acute hematological toxicity in postoperative gynecological cancer patients

    PubMed Central

    Li, Qian; Jiang, Ming-Hua; Chen, Jing; Liu, Wei; Zhu, Bi-Qing; Lu, E-Mei

    2016-01-01

    Objective: To identify the association between radiation dose volume and acute hematological toxicity (HT) in postoperative gynecological cancer patients receiving whole pelvic radiotherapy (RT) or intensity-modulated RT (IMRT), a principal component regression model was used to calculate HT. Methods: Women (n=100) receiving with or without chemotherapy RT were retrospectively analyzed, 52 of whom received chemotherapy (paclitaxel and nedaplatin). The pelvis and lumbar vertebrae, defined as the prolong-pelvic bone marrow, were divided into the (1) combined ilium, ischium and pubis and the (2) lumbar vertebrae and the sacrum. The V5-V40 of subsides was calculated. The complete blood counts were recorded weekly. The principal component analysis was performed on volumes which generated the principal components (PCs), followed by using a logistic regression model. Results: Forty-seven patients presented with grade 2-3 HT during RT. Chemotherapy increased the incidence of HT compared with RT alone (70.21% vs. 29.79%; p=0.001). Fifty-three patients with persistent HT developed more serious HT at an earlier stage of RT. The chemotherapy cycles and three PCs associated with grade 2-3 HT was identified to form the resulting principal logistic regression model. Conclusion: A new method to calculate the NTCP was achieved by PCs logistic regression. PMID:28083062

  9. Alignment of 700 globin sequences: extent of amino acid substitution and its correlation with variation in volume.

    PubMed Central

    Kapp, O. H.; Moens, L.; Vanfleteren, J.; Trotman, C. N.; Suzuki, T.; Vinogradov, S. N.

    1995-01-01

    Seven-hundred globin sequences, including 146 nonvertebrate sequences, were aligned on the basis of conservation of secondary structure and the avoidance of gap penalties. Of the 182 positions needed to accommodate all the globin sequences, only 84 are common to all, including the absolutely conserved PheCD1 and HisF8. The mean number of amino acid substitutions per position ranges from 8 to 13 for all globins and 5 to 9 for internal positions. Although the total sequence volumes have a variation approximately 2-3%, the variation in volume per position ranges from approximately 13% for the internal to approximately 21% for the surface positions. Plausible correlations exist between amino acid substitution and the variation in volume per position for the 84 common and the internal but not the surface positions. The amino acid substitution matrix derived from the 84 common positions was used to evaluate sequence similarity within the globins and between the globins and phycocyanins C and colicins A, via calculation of pairwise similarity scores. The scores for globin-globin comparisons over the 84 common positions overlap the globin-phycocyanin and globin-colicin scores, with the former being intermediate. For the subset of internal positions, overlap is minimal between the three groups of scores. These results imply a continuum of amino acid sequences able to assume the common three-on-three alpha-helical structure and suggest that the determinants of the latter include sites other than those inaccessible to solvent. PMID:8535255

  10. Correlation of Electrolyte Volume and Electrochemical Performance in Lithium-Ion Pouch Cells with Graphite Anodes and NMC532 Cathodes

    DOE PAGES

    An, Seong Jin; Li, Jianlin; Mohanty, Debasish; ...

    2017-04-07

    The work herein reports on studies aimed at exploring the correlation between electrolyte volume and electrochemical performance of full cell, pouch-cells consisting of graphite/ Li1.02Ni0.50Mn0.29Co0.19O2 (NMC-532) as the electrodes and 1.2 M LiPF6 in ethylene carbonate:ethylmethyl carbonate (EC:EMC) as the electrolyte. In addition, it is demonstrated that a minimum electrolyte volume factor of 1.9 times the total pore volume of cell components (cathode, anode, and separator) is needed for long-term cyclability and low impedance. Less electrolyte results in an increase of the measured Ohmic resistances. Increased resistance ratios for charge transfer and passivation layers at cathode, relative to initial values,more » were 1.5 2.0 after 100 cycles. At the cathode, the resistance from charge transfer was 2-3 times higher than for passivation layers. Lastly, differential voltage analysis showed that anodes were less delithiated after discharging as the cells were cycled.« less

  11. The HIV Workforce in New York State: Does Patient Volume Correlate with Quality?

    PubMed

    O'Neill, Maeve; Karelas, Gregory D; Feller, Daniel J; Knudsen-Strong, Emily; Lajeunesse, Dawn; Tsui, Dennis; Gordon, Peter; Agins, Bruce D

    2015-12-15

    Knowledge of care practices among clinicians who annually treat <20 human immunodeficiency virus (HIV)-positive patients with antiretroviral therapy (ART) is insufficient, despite their number, which is likely to increase given shifting healthcare policies. We analyze the practices, distribution and quality of care provided by low-volume prescribers (LVPs) based on available data sources in New York State. We communicated with 1278 (66%) of the LVPs identified through a statewide claims database to determine the circumstances under which they prescribed ART in federal fiscal year 2009. We reviewed patient records from 84 LVPs who prescribed ART routinely and compared their performance with that of experienced clinicians practicing in established HIV programs. Of the surveyed LVPs, 368 (29%) provided routine ambulatory care for 2323 persons living with HIV/AIDS, and 910 LVPs cited other reasons for prescribing ART. Although the majority of LVPs (73%) practiced in New York City, patients living upstate were more likely to be cared for by a LVP (odds ratio, 1.7; 95% confidence interval, 1.4-1.9). Scores for basic HIV performance measures, including viral suppression, were significantly higher in established HIV programs than for providers who wrote prescriptions for <20 persons living with HIV/AIDS (P < .01). We estimate that 33% of New York State clinicians who provide ambulatory HIV care are LVPs. Our findings suggest that the quality of care associated with providers who prescribe ART for <20 patients is lower than that provided by more experienced providers. Access to experienced providers as defined by patient volume is an important determinant of delivering high-quality care and should guide HIV workforce policy decisions. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  12. Perfusion computed tomography of intracranial meningiomas: In vivo correlation of cerebral blood volume and vascular permeability.

    PubMed

    Granata, Francesca; Morabito, Rosa; Alafaci, Concetta; Barresi, Valeria; Tomasello, Francesco; Vinci, Sergio; Mormina, Enricomaria; Calamuneri, Alessandro; Grasso, Giovanni; Salpietro, Francesco Maria; Longo, Marcello

    2015-06-01

    A noninvasive method to predict the grade of a meningioma would be desirable since it would anticipate information about tumour nature, recurrence and improve tumour management and outcomes. The aim of the present study was to assess the ability of perfusion computed tomography (PCT) technique in predicting the meningioma grade before surgery. Data from PCT, such as cerebral blood volume (CBV) and permeability surface (PS), were correlated with immunohistolopathological information. Twenty-three patients with a diagnosis of intracranial meningioma underwent PCT for pre-surgical evaluation of CBV and PS. During surgery, samples from the centre and periphery of the tumour were obtained. Two correspondent regions of interest (ROIs) were drawn on CBV and PS maps. Central and peripheral CBV and PS mean values were calculated. PCT parameters were correlated to CD-34 and endoglin. There was a positive correlation between PS and CD-34. No correlation was found between PS values and endoglin, CBV values and CD-34 and endoglin values. Our findings suggest that PCT may support conventional morphological imaging in predicting meningioma grading before surgery. © The Author(s) 2015.

  13. Euclidean and fractal geometry of microvascular networks in normal and neoplastic pituitary tissue.

    PubMed

    Di Ieva, Antonio; Grizzi, Fabio; Gaetani, Paolo; Goglia, Umberto; Tschabitscher, Manfred; Mortini, Pietro; Rodriguez y Baena, Riccardo

    2008-07-01

    In geometrical terms, tumour vascularity is an exemplary anatomical system that irregularly fills a three-dimensional Euclidean space. This physical characteristic and the highly variable shapes of the vessels lead to considerable spatial and temporal heterogeneity in the delivery of oxygen, nutrients and drugs, and the removal of metabolites. Although these biological characteristics are well known, quantitative analyses of newly formed vessels in two-dimensional histological sections still fail to view their architecture as a non-Euclidean geometrical entity, thus leading to errors in visual interpretation and discordant results from different laboratories concerning the same tumour. We here review the literature concerning microvessel density estimates (a Euclidean-based approach quantifying vascularity in normal and neoplastic pituitary tissues) and compare the results. We also discuss the limitations of Euclidean quantitative analyses of vascularity and the helpfulness of a fractal geometry-based approach as a better means of quantifying normal and neoplastic pituitary microvasculature.

  14. Clinical Roles of Lung Volumes Detected by Body Plethysmography and Helium Dilution in Asthmatic Patients: A Correlation and Diagnosis Analysis

    PubMed Central

    Luo, Jian; Liu, Dan; Chen, Guo; Liang, Binmiao; Liu, Chuntao

    2017-01-01

    Roles of lung volumes in asthma remain controversial. We aimed to evaluate the efficacy of lung volumes in differentiating asthma severity levels. Consecutive outpatients with chronic persistent asthma were enrolled, and body plethysmography (BP) and helium dilution (HD) were performed simultaneously to extract RV%pred, TLC%pred, and RV/TLC. Significant negative correlations were found between FEV1%pred and RV%pred (r = −0.557, P < 0.001), TLC%pred (r = −0.387, P < 0.001), and RV/TLC (r = −0.485, P < 0.001) measured by BP, as well as difference in volumes between these two techniques (ΔRV%pred, ΔTLC%pred and ΔRV/TLC). In mild and moderate asthma, AUC of RV%pred detected by BP and ΔTLC%pred was 0.723 (95%CI 0.571–0.874, P = 0.005) and 0.739 (95%CI 0.607–0.872, P = 0.002) with sensitivity and specificity being 79.41% and 88.24%, and 65.22% and 56.52% at cut-off of 145.40% and 14.23%, respectively. In moderate and severe asthma, AUC of RV%pred detected by BP and ΔTLC%pred was 0.782 (95%CI 0.671–0.893, P < 0.001) and 0.788 (95%CI 0.681–0.894, P < 0.002) with sensitivity and specificity being 77.78% and 97.22%, and 73.53% and 52.94% at cut-off of 179.85% and 20.22%, respectively. In conclusion, lung volumes are reliable complement of FEV1 in identifying asthma severity levels. PMID:28098214

  15. Increased Urinary Cystatin-C Levels Correlate with Reduced Renal Volumes in Neonates with Intrauterine Growth Restriction.

    PubMed

    Barbati, Antonella; Cappuccini, Benito; Aisa, Maria Cristina; Grasselli, Chiara; Zamarra, Mariarosalba; Bini, Vittorio; Bellomo, Gianni; Orlacchio, Aldo; Di Renzo, Gian Carlo

    2016-01-01

    Exposure to intrauterine growth retardation (IUGR) can have a negative impact on nephrogenesis resulting in limited fetal kidney development and supporting the hypothesis that IUGR represents a risk for renal function and long-term renal disease. Cystatin-C (Cys-C), a strong inhibitor of cysteine proteinases, is freely filtered by the kidney glomerulus and is reabsorbed by the tubules, where it is almost totally catabolized; what remains is subsequently eliminated in urine. In tubular diseases and in hyperfiltration conditions, it seems reasonable to postulate that Cys-C degradation would decrease, and consequently an increase in its urinary elimination would be observed. The aim of this study was to investigate the urinary excretion of Cys-C simultaneously with the assessment of renal volumes in adequate for gestational age (AGA) and IUGR neonates in order to identify its clinical value in IUGR. Urinary Cys-C levels were measured using the enzyme immunoassay DetectX® Human Cystatin C kit in IUGR and AGA neonates. Whole renal and renal cortex volumes were assessed with ultrasounds (Vocal II; Software, GE). Urinary Cys-C levels in IUGR were significantly higher than those found in AGA and were negatively correlated to reduced whole renal and renal cortex volumes. The increased levels of Cys-C in the urine of neonates with IUGR were significantly associated with reduced renal/renal cortex volumes, suggesting that Cys-C could be taken as a surrogate of nephron mass. It also could be used as an early biochemical marker to identify IUGR neonates at high risk of developing long-term renal disease and to select patients for monitoring during childhood. © 2016 S. Karger AG, Basel.

  16. Right Anterior Cingulate Cortical Thickness and Bilateral Striatal Volume Correlate with CBCL Aggressive Behavior Scores in Healthy Children

    PubMed Central

    Ducharme, Simon; Hudziak, James J; Botteron, Kelly N; Ganjavi, Hooman; Lepage, Claude; Collins, D Louis; Albaugh, Matthew D.; Evans, Alan C; Karama, Sherif

    2011-01-01

    Background The anterior cingulate cortex (ACC), orbito-frontal cortex (OFC) and basal ganglia have been implicated in pathological aggression. This study aimed at identifying neuroanatomical correlates of impulsive aggression in healthy children. Methods Data from 193 representative 6–18 year-old healthy children were obtained from the NIH MRI Study of Normal Brain Development after a blinded quality control (1). Cortical thickness and subcortical volumes were obtained with automated software. Aggression levels were measured with the Aggressive Behavior scale (AGG) of the Child Behavior Checklist (CBCL). AGG scores were regressed against cortical thickness and basal ganglia volumes using first and second-order linear models while controlling for age, gender, scanner site and total brain volume. ‘Gender by AGG’ interactions were analyzed. Results There were positive associations between bilateral striatal volumes and AGG scores (right: r=0.238, p=0.001; left: r=0.188, p=0.01). A significant association was found with right ACC and subgenual ACC cortical thickness in a second-order linear model (p<0.05, corrected). High AGG scores were associated with a relatively thin right ACC cortex. An ‘AGG by gender’ interaction trend was found in bilateral OFC and ACC associations with AGG scores. Conclusion This study shows the existence of relationships between impulsive aggression in healthy children and the structure of the striatum and right ACC. It also suggests the existence of gender specific patterns of association in OFC/ACC grey matter. These results may guide research on oppositional-defiant and conduct disorders. PMID:21531391

  17. The cosmic X-ray background-IRAS galaxy correlation and the local X-ray volume emissivity

    NASA Technical Reports Server (NTRS)

    Miyaji, Takamitsu; Lahav, Ofer; Jahoda, Keith; Boldt, Elihu

    1994-01-01

    We have cross-correlated the galaxies from the IRAS 2 Jy redshift survey sample and the 0.7 Jy projected sample with the all-sky cosmic X-ray background (CXB) map obtained from the High Energy Astronomy Observatory (HEAO) 1 A-2 experiment. We have detected a significant correlation signal between surface density of IRAS galaxies and the X-ray background intensity, with W(sub xg) = (mean value of ((delta I)(delta N)))/(mean value of I)(mean value of N)) of several times 10(exp -3). While this correlation signal has a significant implication for the contribution of the local universe to the hard (E greater than 2 keV) X-ray background, its interpretation is model-dependent. We have developed a formulation to model the cross-correlation between CXB surface brightness and galaxy counts. This includes the effects of source clustering and the X-ray-far-infrared luminosity correlation. Using an X-ray flux-limited sample of active galactic nuclei (AGNs), which has IRAS 60 micrometer measurements, we have estimated the contribution of the AGN component to the observed CXB-IRAS galaxy count correlations in order to see whether there is an excess component, i.e., contribution from low X-ray luminosity sources. We have applied both the analytical approach and Monte Carlo simulations for the estimations. Our estimate of the local X-ray volume emissivity in the 2-10 keV band is rho(sub x) approximately = (4.3 +/- 1.2) x 10(exp 38) h(sub 50) ergs/s/cu Mpc, consistent with the value expected from the luminosity function of AGNs alone. This sets a limit to the local volume emissivity from lower luminosity sources (e.g., star-forming galaxies, low-ionization nuclear emission-line regions (LINERs)) to rho(sub x) less than or approximately = 2 x 10(exp 38) h(sub 50) ergs/s/cu Mpc.

  18. A Critical Examination of Relative Concentrations of Volume-correlated and Surface-correlated Submicron Globules of Pure Fe-0 in Lunar Soils

    NASA Technical Reports Server (NTRS)

    Basu, A.; McKay, D. S.; Wentworth, S. J.

    2003-01-01

    Impacts on lunar soils produce melt and vapor in an approximate proportion of 7:1. The melt scavenges soil grains of diverse size, quenches and forms agglutinates, thereby converting surface correlated components of soil grains as volume correlated components; simultaneously, parts of the vapor may condense or escape. Cumulative small impacts increase the maturity of the soils, increase the abundance of agglutinates, and increase the concentration of vapor condensated material. Since the discovery of vapor deposited crystalline Fe-0 in vugs of regolith breccias and the theoretical anticipation of amorphous vapor deposits of diverse composition coating lunar soils grains, empirical evidence is gathering in support of such deposits, now commonly called vapor deposited patina (VDP). In addition, submicron globules of Fe-0 are seen to be ubiquitous in VDP. The amorphous VDP lowers the albedo of lunar soils, affects magnetic properties of soils, changes the slopes of uv-vis-ir reflectance spectra, and potentially also alters the gamma and x-ray spectra of lunar soils, compromising compositional inferences from remote sensing.

  19. A Critical Examination of Relative Concentrations of Volume-correlated and Surface-correlated Submicron Globules of Pure Fe-0 in Lunar Soils

    NASA Technical Reports Server (NTRS)

    Basu, A.; McKay, D. S.; Wentworth, S. J.

    2003-01-01

    Impacts on lunar soils produce melt and vapor in an approximate proportion of 7:1. The melt scavenges soil grains of diverse size, quenches and forms agglutinates, thereby converting surface correlated components of soil grains as volume correlated components; simultaneously, parts of the vapor may condense or escape. Cumulative small impacts increase the maturity of the soils, increase the abundance of agglutinates, and increase the concentration of vapor condensated material. Since the discovery of vapor deposited crystalline Fe-0 in vugs of regolith breccias and the theoretical anticipation of amorphous vapor deposits of diverse composition coating lunar soils grains, empirical evidence is gathering in support of such deposits, now commonly called vapor deposited patina (VDP). In addition, submicron globules of Fe-0 are seen to be ubiquitous in VDP. The amorphous VDP lowers the albedo of lunar soils, affects magnetic properties of soils, changes the slopes of uv-vis-ir reflectance spectra, and potentially also alters the gamma and x-ray spectra of lunar soils, compromising compositional inferences from remote sensing.

  20. Euclidean sections of protein conformation space and their implications in dimensionality reduction.

    PubMed

    Duan, Mojie; Li, Minghai; Han, Li; Huo, Shuanghong

    2014-10-01

    Dimensionality reduction is widely used in searching for the intrinsic reaction coordinates for protein conformational changes. We find the dimensionality-reduction methods using the pairwise root-mean-square deviation (RMSD) as the local distance metric face a challenge. We use Isomap as an example to illustrate the problem. We believe that there is an implied assumption for the dimensionality-reduction approaches that aim to preserve the geometric relations between the objects: both the original space and the reduced space have the same kind of geometry, such as Euclidean geometry vs. Euclidean geometry or spherical geometry vs. spherical geometry. When the protein free energy landscape is mapped onto a 2D plane or 3D space, the reduced space is Euclidean, thus the original space should also be Euclidean. For a protein with N atoms, its conformation space is a subset of the 3N-dimensional Euclidean space R(3N). We formally define the protein conformation space as the quotient space of R(3N) by the equivalence relation of rigid motions. Whether the quotient space is Euclidean or not depends on how it is parameterized. When the pairwise RMSD is employed as the local distance metric, implicit representations are used for the protein conformation space, leading to no direct correspondence to a Euclidean set. We have demonstrated that an explicit Euclidean-based representation of protein conformation space and the local distance metric associated to it improve the quality of dimensionality reduction in the tetra-peptide and β-hairpin systems. © 2014 Wiley Periodicals, Inc.

  1. Euclidean wormhole solutions of Einstein-Yang-Mills theory in diverse dimensions

    SciTech Connect

    Yoshida, K.; Hirenzaki, S. ); Shiraishi, K. )

    1990-09-15

    We solve the Euclidean Einstein equations with non-Abelian gauge fields of sufficiently large symmetry in various dimensions. In higher-dimensional spaces, we find the solutions which are similar to so-called scalar wormholes. In four-dimensional space-time, we find singular wormhole solutions with infinite Euclidean action. Wormhole solutions in the three-dimensional Einstein-Yang-Mills theory with a Chern-Simons term are also constructed.

  2. Acoustic Treatment Design Scaling Methods. Volume 5; Analytical and Experimental Data Correlation

    NASA Technical Reports Server (NTRS)

    Chien, W. E.; Kraft, R. E.; Syed, A. A.

    1999-01-01

    The primary purpose of the study presented in this volume is to present the results and data analysis of in-duct transmission loss measurements. Transmission loss testing was performed on full-scale, 1/2-scale, and 115-scale treatment panel samples. The objective of the study was to compare predicted and measured transmission loss for full-scale and subscale panels in an attempt to evaluate the variations in suppression between full- and subscale panels which were ostensibly of equivalent design. Generally, the results indicated an unsatisfactory agreement between measurement and prediction, even for full-scale. This was attributable to difficulties encountered in obtaining sufficiently accurate test results, even with extraordinary care in calibrating the instrumentation and performing the test. Test difficulties precluded the ability to make measurements at frequencies high enough to be representative of subscale liners. It is concluded that transmission loss measurements without ducts and data acquisition facilities specifically designed to operate with the precision and complexity required for high subscale frequency ranges are inadequate for evaluation of subscale treatment effects.

  3. Visceral sensitivity correlates with decreased regional gray matter volume in healthy volunteers: a voxel-based morphometry study.

    PubMed

    Elsenbruch, Sigrid; Schmid, Julia; Kullmann, Jennifer S; Kattoor, Joswin; Theysohn, Nina; Forsting, Michael; Kotsis, Vassilios

    2014-02-01

    Regional changes in brain structure have been reported in patients with altered visceral sensitivity and chronic abdominal pain, such as in irritable bowel syndrome. It remains unknown whether structural brain changes are associated with visceral sensitivity. Therefore, we present the first study in healthy individuals to address whether interindividual variations in gray matter volume (GMV) in pain-relevant regions correlate with visceral sensitivity. In 92 healthy young adults (52 female), we assessed rectal sensory and pain thresholds and performed voxel-based morphometry (VBM) to compute linear regression models with visceral sensory and pain thresholds, respectively, as independent variable and GMV in a priori-defined regions of interest (ROIs) as dependent variable. All results were familywise error (FWE) corrected at a level of PFWE<.05 and covaried for age. The mean (±SEM) rectal thresholds were 14.78±0.46mm Hg for first sensation and 33.97±1.13mm Hg for pain, without evidence of sex differences. Lower rectal sensory threshold (ie, increased sensitivity) correlated significantly with reduced GMV in the thalamus, insula, posterior cingulate cortex, ventrolateral and orbitofrontal prefrontal cortices, amygdala, and basal ganglia (all PFWE<.05). Lower rectal pain threshold was associated with reduced GMV in the right thalamus (PFWE=.051). These are the first data supporting that increased visceral sensitivity correlates with decreased gray matter volume in pain-relevant brain regions. These findings support that alterations in brain morphology not only occur in clinical pain conditions but also occur according to normal interindividual variations in visceral sensitivity. Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  4. Power law correlations in galaxy distribution and finite volume effects from the Sloan Digital Sky Survey Data Release Four

    NASA Astrophysics Data System (ADS)

    Sylos Labini, F.; Vasilyev, N. L.; Baryshev, Y. V.

    2007-04-01

    We discuss the estimation of galaxy correlation properties in several volume limited samples, in different sky regions, obtained from the Fourth Data Release of the Sloan Digital Sky Survey. The small scale properties are characterized through the determination of the nearest neighbor probability distribution. By using a very conservative statistical analysis, in the range of scales [ 0.5, ~30] Mpc/h we detect power-law correlations in the conditional density in redshift space, with an exponent γ=1.0~± 0.1. This behavior is stable in all the different samples we considered; thus it does not depend on galaxy luminosity. In the range of scales [ ~30, ~100] Mpc/h we find evidence for systematic unaveraged fluctuations and we discuss in detail the problems induced by finite volume effects on the determination of the conditional density. We conclude that in such a range of scales there is evidence for a smaller power-law index of the conditional density. However we cannot distinguish between two possibilities: (i) that a crossover to homogeneity (corresponding to γ=0 in the conditional density) occurs before 100 Mpc/h; (ii) that correlations extend to scales of order 100 Mpc/h (with a smaller exponent 0< γ <1). We emphasize that galaxy distributions in these samples present large fluctuations at the largest scales probed, corresponding to the presence of large scale structures extending up to the boundaries of the present survey. We discuss several differences between the behavior of the conditional density in mock galaxy catalogs built from cosmological N-body simulations and real data. We discuss some theoretical implications of such differences considering also the super-homogeneous features of primordial density fields.

  5. The correlation between pulsatile intracranial pressure and indices of intracranial pressure-volume reserve capacity: results from ventricular infusion testing.

    PubMed

    Eide, Per Kristian

    2016-12-01

    OBJECTIVE The objective of this study was to examine how pulsatile and static intracranial pressure (ICP) scores correlate with indices of intracranial pressure-volume reserve capacity, i.e., intracranial elastance (ICE) and intracranial compliance (ICC), as determined during ventricular infusion testing. METHODS All patients undergoing ventricular infusion testing and overnight ICP monitoring during the 6-year period from 2007 to 2012 were included in the study. Clinical data were retrieved from a quality registry, and the ventricular infusion pressure data and ICP scores were retrieved from a pressure database. The ICE and ICC (= 1/ICE) were computed during the infusion phase of the infusion test. RESULTS During the period from 2007 to 2012, 82 patients with possible treatment-dependent hydrocephalus underwent ventricular infusion testing within the department of neurosurgery. The infusion tests revealed a highly significant positive correlation between ICE and the pulsatile ICP scores mean wave amplitude (MWA) and rise-time coefficient (RTC), and the static ICP score mean ICP. The ICE was negatively associated with linear measures of ventricular size. The overnight ICP recordings revealed significantly increased MWA (> 4 mm Hg) and RTC (> 20 mm Hg/sec) values in patients with impaired ICC (< 0.5 ml/mm Hg). CONCLUSIONS In this study cohort, there was a significant positive correlation between pulsatile ICP and ICE measured during ventricular infusion testing. In patients with impaired ICC during infusion testing (ICC < 0.5 ml/mm Hg), overnight ICP recordings showed increased pulsatile ICP (MWA > 4 mm Hg, RTC > 20 mm Hg/sec), but not increased mean ICP (< 10-15 mm Hg). The present data support the assumption that pulsatile ICP (MWA and RTC) may serve as substitute markers of pressure-volume reserve capacity, i.e., ICE and ICC.

  6. Tumor Volume Reduction Rate Measured by Magnetic Resonance Volumetry Correlated With Pathologic Tumor Response of Preoperative Chemoradiotherapy for Rectal Cancer

    SciTech Connect

    Yeo, Seung-Gu; Kim, Dae Yong; Kim, Tae Hyun; Jung, Kyung Hae; Hong, Yong Sang; Chang, Hee Jin; Park, Ji Won; Lim, Seok-Byung; Choi, Hyo Seong; Jeong, Seung-Yong

    2010-09-01

    Purpose: To determine whether the tumor volume reduction rate (TVRR) measured using three-dimensional region-of-interest magnetic resonance volumetry correlates with the pathologic tumor response after preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer. Methods and Materials: The study included 405 patients with locally advanced rectal cancer (cT3-T4) who had undergone preoperative CRT and radical proctectomy. The tumor volume was measured using three-dimensional region-of-interest magnetic resonance volumetry before and after CRT but before surgery. We analyzed the correlation between the TVRR and the pathologic tumor response in terms of downstaging and tumor regression grade (TRG). Downstaging was defined as ypStage 0-I (ypT0-T2N0M0), and the TRG proposed by Dworak et al. was used. Results: The mean TVRR was 65.0% {+-} 22.3%. Downstaging and complete regression occurred in 167 (41.2%) and 58 (14.3%) patients, respectively. The TVRRs according to ypT classification (ypT0-T2 vs. ypT3-T4), ypN classification (ypN0 vs. ypN1-N2), downstaging (ypStage 0-I vs. ypStage II-III), good regression (TRG 3-4 vs. TRG 1-2), and complete regression (TRG 4 vs. TRG 1-3) were all significantly different (p <.05). When the TVRR was categorized into three groups (<60%, 60-80%, and >80%), the rates of ypT0-T2, ypN0, downstaging, and good regression were all significantly greater for patients with a TVRR of {>=}60%, as was the complete regression rate for patients with a TVRR >80% (p <.05). Conclusion: The TVRR measured using three-dimensional region-of-interest magnetic resonance volumetry correlated significantly with the pathologic tumor response in terms of downstaging and TRG after preoperative CRT for locally advanced rectal cancer.

  7. Biological tumor volume in 18FET-PET before radiochemotherapy correlates with survival in GBM.

    PubMed

    Suchorska, Bogdana; Jansen, Nathalie L; Linn, Jennifer; Kretzschmar, Hans; Janssen, Hendrik; Eigenbrod, Sabina; Simon, Matthias; Pöpperl, Gabriele; Kreth, Friedrich W; la Fougere, Christian; Weller, Michael; Tonn, Joerg C

    2015-02-17

    The aim of this prospective longitudinal study was to identify static and dynamic O-(2-[(18)F]fluoroethyl)-L-tyrosine PET ((18)FET-PET)-derived imaging biomarkers in patients with glioblastoma (GBM). Seventy-nine patients with newly diagnosed GBM were included; 42 patients underwent stereotactic biopsy (unresectable tumors) and 37 patients microsurgical tumor resection. All patients were scheduled to receive radiotherapy plus concomitant and adjuvant temozolomide (RCx/TMZ). (18)FET-PET evaluation using static and dynamic analysis was done before biopsy/resection, after resection, 4 to 6 weeks following RCx, and after 3 cycles of TMZ. Endpoints were survival and progression-free-survival. Prognostic factors were obtained from proportional hazards models. Biological tumor volume before RCx (BTV(preRCx)) was the most important (18)FET-PET-derived imaging biomarker and was independent of MGMT promoter methylation and clinical prognostic factors: patients with smaller BTV(preRCx) had significantly longer progression-free and overall survival (OS). (18)FET time-activity curves (TACs) before treatment and their changes after RCx were also related to outcome; patients with initially increasing TACs experienced longer OS. BTV(preRCx) and TAC represent important (18)FET-PET-derived imaging biomarkers in GBM. Increasing TACs are associated with prolonged OS. The BTV(preRCx) is a strong prognostic factor for progression-free survival and OS independent of the mode of surgery. Our data furthermore suggest that patients harboring resectable GBM might benefit from maximal PET-guided tumor resection. © 2015 American Academy of Neurology.

  8. Left atrial minimum volume and reservoir function as correlates of left ventricular diastolic function: impact of left ventricular systolic function.

    PubMed

    Russo, Cesare; Jin, Zhezhen; Homma, Shunichi; Rundek, Tatjana; Elkind, Mitchell S V; Sacco, Ralph L; Di Tullio, Marco R

    2012-05-01

    Left atrial (LA) maximum volume (LAV(max)) is an indicator of left ventricular (LV) diastolic function. However, LAV(max) is also influenced by systolic events, whereas the LA minimum volume (LAV(min)) is directly exposed to LV pressure. The authors hypothesised that LAV(min) may be a better correlate of LV diastolic function than LAV(max). Cross-sectional. University hospital. 357 participants from a community-based cohort study. LA volumes and reservoir function, measured as total LA emptying volume (LAEV) and LA emptying fraction (LAEF), were assessed by real-time three-dimensional echocardiography. LV diastolic function was assessed by trans-mitral early (E) and late (A) Doppler velocities and mitral early diastolic velocity by tissue-Doppler (e'). LV systolic function was assessed by LV ejection fraction (LVEF) and global longitudinal strain (GLS) by speckle-tracking. LAV(min) significantly increased with worsening diastolic dysfunction (p<0.001), whereas the increase in LAV(max) was less pronounced (p=0.07). LAEV and LAEF decreased with worsening diastolic dysfunction (both p<0.001). In linear regressions, LAV(min) and LAV(max) were significant predictors of E/e', with higher parameter estimates for LAV(min). In multivariate models, LAV(min) resulted strongly associated with E/e' (β=0.45, p<0.001), whereas LAV(max) was not (β=-0.16, p=0.08). LA reservoir function was better associated with GLS than LVEF. In multivariate analyses, GLS was significantly associated with LAV(max) (β=-0.15, p=0.002), LAEV (β=-0.37, p<0.001) and LAEF (β=-0.28, p<0.001) but not with LAV(min). LAV(min) is a better correlate of LV diastolic function than LAV(max). The impact of LV longitudinal systolic function on LA reservoir function might explain the weaker relation between LAV(max) and LV diastolic function.

  9. Fast and Accurate Calculation of Protein Depth by Euclidean Distance Transform

    PubMed Central

    Xu, Dong; Li, Hua; Zhang, Yang

    2014-01-01

    The depth of each atom/residue in a protein structure is a key attribution that has been widely used in protein structure modeling and function annotation. However, the accurate calculation of depth is time consuming. Here, we propose to use the Euclidean distance transform (EDT) to calculate the depth, which conveniently converts the protein structure to a 3D gray-scale image with each pixel labeling the minimum distance of the pixel to the surface of the molecule (i.e. the depth). We tested the proposed EDT method on a set of 261 non-redundant protein structures. The data show that the EDT method is 2.6 times faster than the widely used method by Chakravarty and Varadarajan. The depth value by EDT method is also highly accurate, which is almost identical to the depth calculated by exhaustive search (Pearson’s correlation coefficient≈1). We believe the EDT-based depth calculation program can be used as an efficient tool to assist the studies of protein fold recognition and structure-based function annotation. PMID:25035865

  10. Quantifying uncertainty in soot volume fraction estimates using Bayesian inference of auto-correlated laser-induced incandescence measurements

    NASA Astrophysics Data System (ADS)

    Hadwin, Paul J.; Sipkens, T. A.; Thomson, K. A.; Liu, F.; Daun, K. J.

    2016-01-01

    Auto-correlated laser-induced incandescence (AC-LII) infers the soot volume fraction (SVF) of soot particles by comparing the spectral incandescence from laser-energized particles to the pyrometrically inferred peak soot temperature. This calculation requires detailed knowledge of model parameters such as the absorption function of soot, which may vary with combustion chemistry, soot age, and the internal structure of the soot. This work presents a Bayesian methodology to quantify such uncertainties. This technique treats the additional "nuisance" model parameters, including the soot absorption function, as stochastic variables and incorporates the current state of knowledge of these parameters into the inference process through maximum entropy priors. While standard AC-LII analysis provides a point estimate of the SVF, Bayesian techniques infer the posterior probability density, which will allow scientists and engineers to better assess the reliability of AC-LII inferred SVFs in the context of environmental regulations and competing diagnostics.

  11. MRI study of caudate nucleus volume and its cognitive correlates in neuroleptic-naive patients with schizotypal personality disorder.

    PubMed

    Levitt, James J; McCarley, Robert W; Dickey, Chandlee C; Voglmaier, Martina M; Niznikiewicz, Margaret A; Seidman, Larry J; Hirayasu, Yoshio; Ciszewski, Aleksandra A; Kikinis, Ron; Jolesz, Ferenc A; Shenton, Martha E

    2002-07-01

    "Cognitive" circuits anatomically link the frontal lobe to subcortical structures; therefore, pathology in any of the core components of these circuits, such as in the caudate nucleus, may result in neurobehavioral syndromes similar to those of the frontal lobe. Neuroleptic medication, however, affects the size of the caudate nucleus. For this reason, individuals diagnosed with schizotypal personality disorder offer an ideal group for the measurement of the caudate nucleus because they may be genetically related to individuals with schizophrenia but do not require neuroleptic treatment because of their less severe symptoms. Magnetic resonance imagining (MRI) scans obtained on a 1.5-T magnet with 1.5-mm contiguous slices were used to measure the caudate nucleus and lateral ventricles in 15 right-handed male subjects with schizotypal personality disorder who had no previous neuroleptic exposure and in 14 normal comparison subjects. Subjects were group matched for parental socioeconomic status, handedness, and gender. First, the authors found significantly lower left and right absolute (13.1%, 13.2%) and relative (9.1%, 9.2%) caudate nucleus volumes in never-medicated subjects with schizotypal personality disorder than in normal subjects. Second, they found significant, inverse correlations between caudate nucleus volume and the severity of perseveration in two distinct working memory tasks in these neuroleptic-naive subjects with schizotypal personality disorder. These data are consistent with the findings of reduced caudate nucleus volume reported in studies of neuroleptic-naive patients experiencing their first episode of schizophrenia and support the association of intrinsic pathology in the caudate nucleus with abnormalities in working memory in the schizophrenia spectrum.

  12. Multilayered poly(vinylidene fluoride) composite membranes with improved interfacial compatibility: correlating pervaporation performance with free volume properties.

    PubMed

    An, Quanfu; Chen, Jung-Tsai; De Guzman, Manuel; Hung, Wei-Song; Lee, Kueir-Rarn; Lai, Juin-Yih

    2011-09-06

    A spin-coating process integrated with an ozone-induced graft polymerization technique was applied in this study. The purpose was to improve the poor interfacial compatibility between a selective layer of poly(2-hydroxyethyl methacrylate) (PHEMA) and the surface of a poly(vinylidene fluoride) (PVDF) substrate. The composite membranes thus fabricated were tested for their pervaporation performance in dehydrating an ethyl acetate/water mixture. Furthermore, the composite membranes were characterized by field emission scanning electron microscopy (FE-SEM) for morphological change observation and by Fourier transform infrared spectroscopy equipped with attenuated total reflectance (ATR-FTIR) for surface chemical composition analysis. Effects of grafting density and spin-coating speed on pervaporation performance were examined. The composite membrane pervaporation performance was elucidated by means of free volume and depth profile data obtained with the use of a variable monoenergy slow positron beam (VMSPB). Results indicated that a smaller free volume was correlated with a higher pervaporation performance of a composite membrane consisting of a selective layer of spin-coated PHEMA on a PHEMA-grafted PVDF substrate (S-PHEMA/PHEMA-g-PVDF). The composite membrane depth profile illustrated that an S-PHEMA layer spin-coated at a higher revolutions per minute (rpm) was thinner and denser than that at a lower rpm.

  13. Direct observation of spatiotemporal dependence of anomalous diffusion in inhomogeneous fluid by sampling-volume-controlled fluorescence correlation spectroscopy

    NASA Astrophysics Data System (ADS)

    Masuda, Akiko; Ushida, Kiminori; Okamoto, Takayuki

    2005-12-01

    The direct observation of a spatiotemporal behavior of anomalous diffusion in aqueous polymer [hyaluronan (HA)] solution was achieved by fluorescence correlation spectroscopy (FCS) using a modified instrument, enabling continuous change of the confocal volume of a microscope, namely, sampling-volume-controlled (SVC) FCS (SVC-FCS). Since HA chains form a mesh structure with a pore size of about 10-40nm , the observed diffusion coefficient (Dobs) is markedly dependent on the diffusion distance (L) . By SVC-FCS, the curve of the distance dependence of diffusion coefficient was directly obtained as a continuous profile in L=245-600nm showing evidence of anomalous diffusion. On plotting Dobs against either of the sampling time (τobs) or the diffusion distance (L) , Dobs turnover was observed near the anomalous diffusion area. The appearance of this turnover is attributed to the nonuniform mesh structure that can be observed only by a fast observation and that should be dynamically averaged by polymer motions with large τobs . This behavior is similar to that revealed in glass, colloidal systems, and gel solutions using dynamic light scattering, neutron scattering, and other techniques.

  14. Grey matter volume correlates of cerebrospinal markers of Alzheimer-pathology in Parkinson's disease and related dementia.

    PubMed

    Compta, Yaroslau; Ibarretxe-Bilbao, Naroa; Pereira, Joana B; Junqué, Carme; Bargalló, Núria; Tolosa, Eduardo; Valldeoriola, Francesc; Muñoz, Esteban; Camara, Ana; Buongiorno, Mariateresa; Martí, Maria Jose

    2012-09-01

    Regional brain grey matter volume (GMV) reductions and abnormal cerebrospinal fluid (CSF) levels of τ and Aβ, extensively studied as biomarkers of Alzheimer's disease (AD), have also been reported in Parkinson's disease (PD) and related dementia (PDD). However, the relationship between these CSF and MRI biomarkers in PD and PDD remains unexplored. We studied these associations in 33 PD patients (18 with no dementia [PDND]; 15 fulfilling PDD criteria) and 12 neurologically unimpaired controls, with neuropsychological assessment, CSF ELISA studies, and voxel-based morphometry (VBM) analysis of high-field brain MRI. Neuropsychological assessment showed a gradation in cognitive performance from controls to PDND (significantly worse on visuospatial performance) and then to PDD (more impaired on memory, naming, fluency and visuospatial functions). No CSF-VBM correlations were found in controls or PDND patients. In contrast, in the analysis of both the PDD subgroup and the entire PD (PDND + PDD) sample, we found significant negative CSF-GMV correlations for τ and phospho-τ and significant positive CSF-GMV correlations for Aβ in mostly frontal and temporal structures. The correlations in the entire PD sample fitted with a linear model and were thus unlikely to have been driven solely by the PDD subgroup. Additionally, an association between both the CSF markers and the CSF-associated GMV reductions with several neuropsychological functions was found. We interpret that CSF markers of AD pathology are associated with VBM-measures of brain atrophy in PD-related dementia and within the PD cognitive continuum, and deserve further attention as putative biomarkers of cognitive impairment and dementia in PD. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. Stromal-Derived Factor-1α Correlates With Circulating Endothelial Progenitor Cells and With Acute Lesion Volume in Stroke Patients

    PubMed Central

    Bogoslovsky, Tanya; Spatz, Maria; Chaudhry, Aneeka; Maric, Dragan; Luby, Marie; Frank, Joseph; Warach, Steven

    2016-01-01

    Background and Purpose Endothelial progenitor cells (EPC) are important participants of neovascularization and are mobilized through signaling with stromal-derived factor (SDF-1α), vascular endothelial growth factor (VEGF), granulocyte colony-stimulating factor, and stem cell factor. The association between EPC levels and these growth factors (GF) in acute stroke has not been previously established. We aimed to determine the association between EPC and these GF, and to elucidate a relationship between these GF and stroke severity in acute stroke patients. Methods Seventeen patients were selected from 175 patients with imaging-confirmed acute ischemic stroke. EPC were quantified using CD34, CD133, and VEGF-R2 markers. Plasma VEGF, SDF-1α, granulocyte colony-stimulating factor, and stem cell factor were determined by enzyme-linked immunosorbent assay on days 1 and 3, and brain MRI was performed at baseline and on days 1 and 5 after the stroke onset. Results Levels of SDF-1α strongly (r=0.6) correlated with the numbers of EPC subsets CD133+VEFG-R2+ (P<0.004), CD34+VEGF-R2+ (P<0.01), and CD34+CD133+VEGF-R2+ (P<0.01) on day 1. Stem cell factor strongly (r=0.5) correlated with CD133+VEGF-R2+ (P<0.05). SDF-1α moderately inversely (r<−0.49) correlated with baseline diffusion-weighted imaging lesion volumes (P<0.04). Median levels of SDF-1α (1561 pg/mL) increased (P<0.04) on day 3 compared to day 1 (1379 pg/mL). Similarly, VEGF at day 3 (95 pg/mL) increased (P<0.03) compared to day 1 (64 pg/mL). Conclusions These results indicate that SDF-1α and stem cell factor correlate with an increase in EPC early in ischemic stroke patients. PMID:21257825

  16. 3D Volumetry and its Correlation Between Postoperative Gastric Volume and Excess Weight Loss After Sleeve Gastrectomy.

    PubMed

    Hanssen, Andrés; Plotnikov, Sergio; Acosta, Geylor; Nuñez, José Tomas; Haddad, José; Rodriguez, Carmen; Petrucci, Claudia; Hanssen, Diego; Hanssen, Rafael

    2017-09-15

    The volume of the postoperative gastric remnant is a key factor in excess weight loss (EWL) after sleeve gastrectomy (SG). Traditional methods to estimate gastric volume (GV) after bariatric procedures are often inaccurate; usually conventional biplanar contrast studies are used. Thirty patients who underwent SG were followed prospectively and evaluated at 6 months after the surgical procedure, performing 3D CT reconstruction and gastric volumetry, to establish its relationship with EWL. The gastric remnant was distended with effervescent sodium bicarbonate given orally. Helical CT images were acquired and reconstructed; GV was estimated with the software of the CT device. The relationship between GV and EWL was analyzed. The study allowed estimating the GV in all patients. A dispersion diagram showed an inverse relationship between GV and %EWL. 55.5% of patients with GV ≤ 100 ml had %EWL 25-75% and 38.8% had an %EWL above 75% and patients with GV ≥ 100 ml had an %EWL under 25% (50% of patients) or between 25 and 75% (50% of this group). The Pearson's correlation coefficient was R = 6.62, with bilateral significance (p ≤ .01). The Chi-square result correlating GV and EWL showed a significance of .005 (p ≤ .01). The 3D reconstructions showed accurately the shape and anatomic details of the gastric remnant. 3D volumetry CT scans accurately estimate GV after SG. A significant relationship between GV and EWL 6 months after SG was established, seeming that GV ≥ 100 ml at 6 months of SG is associated with poor EWL.

  17. Application of the digital volume correlation technique for the measurement of displacement and strain fields in bone: a literature review.

    PubMed

    Roberts, Bryant C; Perilli, Egon; Reynolds, Karen J

    2014-03-21

    Digital volume correlation (DVC) provides experimental measurements of displacements and strains throughout the interior of porous materials such as trabecular bone. It can provide full-field continuum- and tissue-level measurements, desirable for validation of finite element models, by comparing image volumes from subsequent µCT scans of a sample in unloaded and loaded states. Since the first application of DVC for measurement of strain in bone tissue, subsequent reports of its application to trabecular bone cores up to whole bones have appeared within the literature. An "optimal" set of procedures capable of precise and accurate measurements of strain, however, still remains unclear, and a systematic review focussing explicitly on the increasing number of DVC algorithms applied to bone or structurally similar materials is currently unavailable. This review investigates the effects of individual parameters reported within individual studies, allowing to make recommendations for suggesting algorithms capable of achieving high accuracy and precision in displacement and strain measurements. These recommendations suggest use of subsets that are sufficiently large to encompass unique datasets (e.g. subsets of 500 µm edge length when applied to human trabecular bone cores, such as cores 10mm in height and 5mm in diameter, scanned at 15 µm voxel size), a shape function that uses full affine transformations (translation, rotation, normal strain and shear strain), the robust normalized cross-correlation coefficient objective function, and high-order interpolation schemes. As these employ computationally burdensome algorithms, researchers need to determine whether they have the necessary computational resources or time to adopt such strategies. As each algorithm is suitable for parallel programming however, the adoption of high precision techniques may become more prevalent in the future.

  18. Measuring local volume fraction, long-wavelength correlations, and fractionation in a phase-separating polydisperse fluid

    SciTech Connect

    Williamson, J. J.; Evans, R. M. L.

    2014-10-28

    We dynamically simulate fractionation (partitioning of particle species) during spinodal gas-liquid separation of a size-polydisperse colloid, using polydispersity up to ∼40% and a skewed parent size distribution. We introduce a novel coarse-grained Voronoi method to minimise size bias in measuring local volume fraction, along with a variety of spatial correlation functions which detect fractionation without requiring a clear distinction between the phases. These can be applied whether or not a system is phase separated, to determine structural correlations in particle size, and generalise easily to other kinds of polydispersity (charge, shape, etc.). We measure fractionation in both mean size and polydispersity between the phases, its direction differing between model interaction potentials which are identical in the monodisperse case. These qualitative features are predicted by a perturbative theory requiring only a monodisperse reference as input. The results show that intricate fractionation takes place almost from the start of phase separation, so can play a role even in nonequilibrium arrested states. The methods for characterisation of inhomogeneous polydisperse systems could in principle be applied to experiment as well as modelling.

  19. Preterm neonatal lateral ventricle volume from three-dimensional ultrasound is not strongly correlated to two-dimensional ultrasound measurements.

    PubMed

    Kishimoto, Jessica; de Ribaupierre, Sandrine; Salehi, Fateme; Romano, Walter; Lee, David S C; Fenster, Aaron

    2016-10-01

    The aim of this study is to compare longitudinal two-dimensional (2-D) and three-dimensional (3-D) ultrasound (US) estimates of ventricle size in preterm neonates with posthemorrhagic ventricular dilatation (PHVD) using quantitative measurements of the lateral ventricles. Cranial 2-D US and 3-D US images were acquired from neonatal patients with diagnosed PHVD within 10 min of each other one to two times per week and analyzed offline. Ventricle index, anterior horn width, third ventricle width, and thalamo-occipital distance were measured on the 2-D images and ventricle volume (VV) was measured from 3-D US images. Changes in the measurements between successive image sets were also recorded. No strong correlations were found between VV and 2-D US measurements ([Formula: see text] between 0.69 and 0.36). Additionally, weak correlations were found between changes in 2-D US measurements and 3-D US VV ([Formula: see text] between 0.13 and 0.02). A trend was found between increasing 2-D US measurements and 3-D US-based VV, but this was not the case when comparing changes between 3-D US VV and 2-D US measurements. If 3-D US-based VV provides a more accurate estimate of ventricle size than 2-D US measurements, moderate-weak correlations with 3-D US suggest that monitoring preterm patients with PHVD using 2-D US measurements alone might not accurately represent whether the ventricles are progressively dilating. A volumetric measure (3-D US or MRI) could be used instead to more accurately represent changes.

  20. Log-Euclidean metrics for fast and simple calculus on diffusion tensors.

    PubMed

    Arsigny, Vincent; Fillard, Pierre; Pennec, Xavier; Ayache, Nicholas

    2006-08-01

    Diffusion tensor imaging (DT-MRI or DTI) is an emerging imaging modality whose importance has been growing considerably. However, the processing of this type of data (i.e., symmetric positive-definite matrices), called "tensors" here, has proved difficult in recent years. Usual Euclidean operations on matrices suffer from many defects on tensors, which have led to the use of many ad hoc methods. Recently, affine-invariant Riemannian metrics have been proposed as a rigorous and general framework in which these defects are corrected. These metrics have excellent theoretical properties and provide powerful processing tools, but also lead in practice to complex and slow algorithms. To remedy this limitation, a new family of Riemannian metrics called Log-Euclidean is proposed in this article. They also have excellent theoretical properties and yield similar results in practice, but with much simpler and faster computations. This new approach is based on a novel vector space structure for tensors. In this framework, Riemannian computations can be converted into Euclidean ones once tensors have been transformed into their matrix logarithms. Theoretical aspects are presented and the Euclidean, affine-invariant, and Log-Euclidean frameworks are compared experimentally. The comparison is carried out on interpolation and regularization tasks on synthetic and clinical 3D DTI data. Copyright 2006 Wiley-Liss, Inc.

  1. Epileptic Seizure Detection with Log-Euclidean Gaussian Kernel-Based Sparse Representation.

    PubMed

    Yuan, Shasha; Zhou, Weidong; Wu, Qi; Zhang, Yanli

    2016-05-01

    Epileptic seizure detection plays an important role in the diagnosis of epilepsy and reducing the massive workload of reviewing electroencephalography (EEG) recordings. In this work, a novel algorithm is developed to detect seizures employing log-Euclidean Gaussian kernel-based sparse representation (SR) in long-term EEG recordings. Unlike the traditional SR for vector data in Euclidean space, the log-Euclidean Gaussian kernel-based SR framework is proposed for seizure detection in the space of the symmetric positive definite (SPD) matrices, which form a Riemannian manifold. Since the Riemannian manifold is nonlinear, the log-Euclidean Gaussian kernel function is applied to embed it into a reproducing kernel Hilbert space (RKHS) for performing SR. The EEG signals of all channels are divided into epochs and the SPD matrices representing EEG epochs are generated by covariance descriptors. Then, the testing samples are sparsely coded over the dictionary composed by training samples utilizing log-Euclidean Gaussian kernel-based SR. The classification of testing samples is achieved by computing the minimal reconstructed residuals. The proposed method is evaluated on the Freiburg EEG dataset of 21 patients and shows its notable performance on both epoch-based and event-based assessments. Moreover, this method handles multiple channels of EEG recordings synchronously which is more speedy and efficient than traditional seizure detection methods.

  2. The Random Link Approximation for the Euclidean Traveling Salesman Problem

    NASA Astrophysics Data System (ADS)

    Cerf, N. J.; Boutet de Monvel, J.; Bohigas, O.; Martin, O. C.; Percus, A. G.

    1997-01-01

    The traveling salesman problem (TSP) consists of finding the length of the shortest closed tour visiting N “cities”. We consider the Euclidean TSP where the cities are distributed randomly and independently in a d-dimensional unit hypercube. Working with periodic boundary conditions and inspired by a remarkable universality in the kth nearest neighbor distribution, we find for the average optimum tour length <~ngle L_Erangle =β_E(d)N^{1-1/d}[1+O(1/N)] with β_E=0.7120± 0.0002 and β_E(3)=0.6979± 0.0002. We then derive analytical predictions for these quantities using the random link approximation, where the lengths between cities are taken as independent random variables. From the “cavity” equations developed by Krauth, Mézard and Parisi, we calculate the associated random link values β_RL(d). For d=1, 2, 3, numerical results show that the random link approximation is a good one, with a discrepancy of less than 2.1% between β_E(d) and β_RL(d). For large d, we argue that the approximation is exact up to O(1d^2) and give a conjecture for β_E(d), in terms of a power series in 1/d, specifying both leading and subleading coefficients. Le problème du voyageur de commerce (TSP) consiste à trouver le chemin fermé le plus court qui relie N “villes”. Nous étudions le TSP euclidien où les villes sont distribuées au hasard de manière décorrélée dans l'hypercube de côté 1, en dimension d. En imposant des conditions aux bords périodiques et guidés par une universalité remarquable de la distribution des kièmes voisins, nous trouvons la longueur moyenne du chemin optimal <~ngle L_Erangle = β_E(d)N^{1-1/d}[1+O(1/N)] , avec β_E= 0,7120 ± 0,0002 et β_E(3)= 0,6979 ± 0,0002. Nous établissons ensuite des prédictions analytiques sur ces quantités à l'aide de l'approximation de liens aléatoires, où les longueurs entre les villes sont des variables aléatoires indépendantes. Grâce aux équations “cavité” développées par Krauth, M

  3. Euclidean Complex Relativistic Mechanics: A New Special Relativity Theory

    NASA Astrophysics Data System (ADS)

    Vossos, Spyridon; Vossos, Elias

    2015-09-01

    Relativity Theory (RT) was fundamental for the development of Quantum Mechanics (QMs). Special Relativity (SR), as is applied until now, cancels the transitive attribute in parallelism, when three observers are related, because Lorentz Boost (LB) is not closed transformation. In this presentation, considering Linear Spacetime Transformation (LSTT), we demand the maintenance of Minkowski Spacetime Interval (S2). In addition, we demand this LSTT to be closed, so there is no need for axes rotation. The solution is the Vossos Matrix (ΛB) containing real and imaginary numbers. As a result, space becomes complex, but time remains real. Thus, the transitive attribute in parallelism, which is equivalent to the Euclidean Request (ER), is also valid for moving observers. Choosing real spacetime for the unmoved observer (O), all the natural sizes are real, too. Using Vossos Transformation (VT) for moving observers, the four-vectors’ zeroth component (such as energy) is real, in contrast with spatial components that are complex, but their norm is real. It is proved that moving (relative to O) human O' meter length, according to Lorentz Boost (LB). In addition, we find Rotation Matrix Vossos-Lorentz (RBL) that turns natural sizes’ complex components to real. We also prove that Speed of Light in Vacuum (c) is invariant, when complex components are used and VT is closed for three sequential observers. After, we find out the connection between two moving (relative to O) observers: X"= ΛLO"(o) ΛLO(O') X', using Lorentz Matrix (ΛL). We applied this theory, finding relations between natural sizes, that are the same as these extracted by Classic Relativity (CR), when two observers are related (i.e. relativistic Doppler shift is the same). But, the results are different, when more than two observers are related. VT of Electromagnetic Tensor (Fμv), leads to Complex Electromagnetic Fields (CEMFs) for a moving observer. When the unmoved observer O and a moving observer O' are

  4. Volume and planar gated cardiac magnetic resonance imaging: a correlative study of normal anatomy with Thallium-201 SPECT and cadaver sections

    SciTech Connect

    Go, R.T.; MacIntyre, W.J.; Yeung, H.N.

    1984-01-01

    Magnetic resonance (MR) gated cardiac imaging was performed in ten subjects using a prototype 0.15-T resistive magnet imaging system. Volume and planar imaging techniques utilizing saturation recovery, proton TI-weighted relaxation time pulse sequences produced images of the heart and great vessels with exquisite anatomic detail that showed excellent correlation with cadaver sections of the heart. The left ventricular myocardial segments also showed excellent correlation with cadaver sections of the heart. The left ventricular myocardial segments also showed excellent correlation with the thallium-201 cardiac single photon emission computed tomography images. Volume acquisition allowed postprocessing selection of tomographic sections in various orientations to optimize visualization of a particular structure of interest. The excellent spatial and contrast resolution afforded by MR volume imaging, which does not involve the use of ionizing radiation and iodinated contrast material, should assure it a significant role in the diagnostic assessment of the cardiovascular system.

  5. Approximability of the d-dimensional Euclidean capacitated vehicle routing problem

    NASA Astrophysics Data System (ADS)

    Khachay, Michael; Dubinin, Roman

    2016-10-01

    Capacitated Vehicle Routing Problem (CVRP) is the well known intractable combinatorial optimization problem, which remains NP-hard even in the Euclidean plane. Since the introduction of this problem in the middle of the 20th century, many researchers were involved into the study of its approximability. Most of the results obtained in this field are based on the well known Iterated Tour Partition heuristic proposed by M. Haimovich and A. Rinnoy Kan in their celebrated paper, where they construct the first Polynomial Time Approximation Scheme (PTAS) for the single depot CVRP in ℝ2. For decades, this result was extended by many authors to numerous useful modifications of the problem taking into account multiple depots, pick up and delivery options, time window restrictions, etc. But, to the best of our knowledge, almost none of these results go beyond the Euclidean plane. In this paper, we try to bridge this gap and propose a EPTAS for the Euclidean CVRP for any fixed dimension.

  6. Nonlinear bivariate dependency of price-volume relationships in agricultural commodity futures markets: A perspective from Multifractal Detrended Cross-Correlation Analysis

    NASA Astrophysics Data System (ADS)

    He, Ling-Yun; Chen, Shu-Peng

    2011-01-01

    Nonlinear dependency between characteristic financial and commodity market quantities (variables) is crucially important, especially between trading volume and market price. Studies on nonlinear dependency between price and volume can provide practical insights into market trading characteristics, as well as the theoretical understanding of market dynamics. Actually, nonlinear dependency and its underlying dynamical mechanisms between price and volume can help researchers and technical analysts in understanding the market dynamics by integrating the market variables, instead of investigating them in the current literature. Therefore, for investigating nonlinear dependency of price-volume relationships in agricultural commodity futures markets in China and the US, we perform a new statistical test to detect cross-correlations and apply a new methodology called Multifractal Detrended Cross-Correlation Analysis (MF-DCCA), which is an efficient algorithm to analyze two spatially or temporally correlated time series. We discuss theoretically the relationship between the bivariate cross-correlation exponent and the generalized Hurst exponents for time series of respective variables. We also perform an empirical study and find that there exists a power-law cross-correlation between them, and that multifractal features are significant in all the analyzed agricultural commodity futures markets.

  7. Extrinsic time formalism for the Euclidean black hole in a box

    NASA Astrophysics Data System (ADS)

    Oliveira-Neto, G.

    1996-02-01

    We return to the problem of Euclidean black holes in thermodynamical equilibrium with radiation, under the conditions of the statistical mechanical canonical ensemble. This time we use Kuchař's ``extrinsic time'' formalism in order to select the set of true dynamical variables. With this set of canonical variables, \\{R~,PR~,M,PM\\}, and York's proposal for the boundary and ``horizon'' terms, we compute a classically consistent total action for the Euclidean black hole. We show explicitly that the ``zero-loop'' partition function derived from this total action is identical to the one already in the literature of this area.

  8. Generalized Thomson problem in arbitrary dimensions and non-euclidean geometries

    NASA Astrophysics Data System (ADS)

    Batle, J.; Bagdasaryan, Armen; Abdel-Aty, M.; Abdalla, S.

    2016-06-01

    Systems of identical particles with equal charge are studied under a special type of confinement. These classical particles are free to move inside some convex region S and on the boundary of it Ω (the S d - 1 -sphere, in our case). We shall show how particles arrange themselves under the sole action of the Coulomb repulsion in many dimensions in the usual Euclidean space, therefore generalizing the so called Thomson problem to many dimensions. Also, we explore how the problem varies when non-Euclidean geometries are considered. We shall see that optimal configurations in all cases possess a high degree of symmetry, regardless of the concomitant dimension or geometry.

  9. Correlation between the 2-Dimensional Extent of Orbital Defects and the 3-Dimensional Volume of Herniated Orbital Content in Patients with Isolated Orbital Wall Fractures

    PubMed Central

    Cha, Jong Hyun; Moon, Myeong Ho; Lee, Yong Hae; Koh, In Chang; Kim, Kyu Nam; Kim, Chang Gyun

    2017-01-01

    Background The purpose of this study was to assess the correlation between the 2-dimensional (2D) extent of orbital defects and the 3-dimensional (3D) volume of herniated orbital content in patients with an orbital wall fracture. Methods This retrospective study was based on the medical records and radiologic data of 60 patients from January 2014 to June 2016 for a unilateral isolated orbital wall fracture. They were classified into 2 groups depending on whether the fracture involved the inferior wall (group I, n=30) or the medial wall (group M, n=30). The 2D area of the orbital defect was calculated using the conventional formula. The 2D extent of the orbital defect and the 3D volume of herniated orbital content were measured with 3D image processing software. Statistical analysis was performed to evaluate the correlations between the 2D and 3D parameters. Results Varying degrees of positive correlation were found between the 2D extent of the orbital defects and the 3D herniated orbital volume in both groups (Pearson correlation coefficient, 0.568−0.788; R2=32.2%−62.1%). Conclusions Both the calculated and measured 2D extent of the orbital defects showed a positive correlation with the 3D herniated orbital volume in orbital wall fractures. However, a relatively large volume of herniation (>0.9 cm3) occurred not infrequently despite the presence of a small orbital defect (<1.9 cm2). Therefore, estimating the 3D volume of the herniated content in addition to the 2D orbital defect would be helpful for determining whether surgery is indicated and ensuring adequate surgical outcomes. PMID:28194344

  10. Assessment of image correlation methods for the estimation of volume flow rates of subsea oil-gas plumes

    NASA Astrophysics Data System (ADS)

    Willert, Christian; Wereley, Steve

    2010-11-01

    The recent uncontrolled release of oil and gas from a failed well into the Gulf of Mexico in the wake of the Deep Water Horizons accident illustrated that the actual release rates are difficult to assess with established surface observation methods. To a large extent this has to with the great depth (˜1500m) at which the oil was released and its subsequent dispersal throughout the vertical water column. Streaming video of the failure site was provided by subsea remotely operated vehicles (ROV) and allow, in principle, the quantification of the release rate on the basis of motion analysis image processing methods. Several correlation based approaches, commonly used in particle image velocimetry (PIV), are investigated with regard to estimating the propagation velocity of large scale features in the visible interface between sea water and oil plume. Together with time scale (video frame rate) and length scale (pipe diameter) the interface velocity of the plume can be estimated. Assuming the plume to be a turbulent free jet the actual volume flow rate of the oil/gas mixture can be then be recovered with reasonable accuracy.

  11. Quantifying Bulk Electrode Strain and Material Displacement within Lithium Batteries via High‐Speed Operando Tomography and Digital Volume Correlation

    PubMed Central

    Finegan, Donal P.; Tudisco, Erika; Scheel, Mario; Robinson, James B.; Taiwo, Oluwadamilola O.; Eastwood, David S.; Lee, Peter D.; Di Michiel, Marco; Bay, Brian; Hall, Stephen A.; Hinds, Gareth; Brett, Dan J. L.

    2015-01-01

    Tracking the dynamic morphology of active materials during operation of lithium batteries is essential for identifying causes of performance loss. Digital volume correlation (DVC) is applied to high‐speed operando synchrotron X‐ray computed tomography of a commercial Li/MnO2 primary battery during discharge. Real‐time electrode material displacement is captured in 3D allowing degradation mechanisms such as delamination of the electrode from the current collector and electrode crack formation to be identified. Continuum DVC of consecutive images during discharge is used to quantify local displacements and strains in 3D throughout discharge, facilitating tracking of the progression of swelling due to lithiation within the electrode material in a commercial, spiral‐wound battery during normal operation. Displacement of the rigid current collector and cell materials contribute to severe electrode detachment and crack formation during discharge, which is monitored by a separate DVC approach. Use of time‐lapse X‐ray computed tomography coupled with DVC is thus demonstrated as an effective diagnostic technique to identify causes of performance loss within commercial lithium batteries; this novel approach is expected to guide the development of more effective commercial cell designs. PMID:27610334

  12. Excluded volume and ion-ion correlation effects on the ionic atmosphere around B-DNA: Theory, simulations, and experiments

    NASA Astrophysics Data System (ADS)

    Ovanesyan, Zaven; Medasani, Bharat; Fenley, Marcia O.; Guerrero-García, Guillermo Iván; Olvera de la Cruz, Mónica; Marucho, Marcelo

    2014-12-01

    The ionic atmosphere around a nucleic acid regulates its stability in aqueous salt solutions. One major source of complexity in biological activities involving nucleic acids arises from the strong influence of the surrounding ions and water molecules on their structural and thermodynamic properties. Here, we implement a classical density functional theory for cylindrical polyelectrolytes embedded in aqueous electrolytes containing explicit (neutral hard sphere) water molecules at experimental solvent concentrations. Our approach allows us to include ion correlations as well as solvent and ion excluded volume effects for studying the structural and thermodynamic properties of highly charged cylindrical polyelectrolytes. Several models of size and charge asymmetric mixtures of aqueous electrolytes at physiological concentrations are studied. Our results are in good agreement with Monte Carlo simulations. Our numerical calculations display significant differences in the ion density profiles for the different aqueous electrolyte models studied. However, similar results regarding the excess number of ions adsorbed to the B-DNA molecule are predicted by our theoretical approach for different aqueous electrolyte models. These findings suggest that ion counting experimental data should not be used alone to validate the performance of aqueous DNA-electrolyte models.

  13. Excluded volume and ion-ion correlation effects on the ionic atmosphere around B-DNA: Theory, simulations, and experiments

    SciTech Connect

    Ovanesyan, Zaven; Marucho, Marcelo; Medasani, Bharat; Fenley, Marcia O.; Guerrero-García, Guillermo Iván; Olvera de la Cruz, Mónica

    2014-12-14

    The ionic atmosphere around a nucleic acid regulates its stability in aqueous salt solutions. One major source of complexity in biological activities involving nucleic acids arises from the strong influence of the surrounding ions and water molecules on their structural and thermodynamic properties. Here, we implement a classical density functional theory for cylindrical polyelectrolytes embedded in aqueous electrolytes containing explicit (neutral hard sphere) water molecules at experimental solvent concentrations. Our approach allows us to include ion correlations as well as solvent and ion excluded volume effects for studying the structural and thermodynamic properties of highly charged cylindrical polyelectrolytes. Several models of size and charge asymmetric mixtures of aqueous electrolytes at physiological concentrations are studied. Our results are in good agreement with Monte Carlo simulations. Our numerical calculations display significant differences in the ion density profiles for the different aqueous electrolyte models studied. However, similar results regarding the excess number of ions adsorbed to the B-DNA molecule are predicted by our theoretical approach for different aqueous electrolyte models. These findings suggest that ion counting experimental data should not be used alone to validate the performance of aqueous DNA-electrolyte models.

  14. Excluded volume and ion-ion correlation effects on the ionic atmosphere around B-DNA: Theory, simulations, and experiments

    PubMed Central

    Ovanesyan, Zaven; Fenley, Marcia O.; Guerrero-García, Guillermo Iván; Olvera de la Cruz, Mónica

    2014-01-01

    The ionic atmosphere around a nucleic acid regulates its stability in aqueous salt solutions. One major source of complexity in biological activities involving nucleic acids arises from the strong influence of the surrounding ions and water molecules on their structural and thermodynamic properties. Here, we implement a classical density functional theory for cylindrical polyelectrolytes embedded in aqueous electrolytes containing explicit (neutral hard sphere) water molecules at experimental solvent concentrations. Our approach allows us to include ion correlations as well as solvent and ion excluded volume effects for studying the structural and thermodynamic properties of highly charged cylindrical polyelectrolytes. Several models of size and charge asymmetric mixtures of aqueous electrolytes at physiological concentrations are studied. Our results are in good agreement with Monte Carlo simulations. Our numerical calculations display significant differences in the ion density profiles for the different aqueous electrolyte models studied. However, similar results regarding the excess number of ions adsorbed to the B-DNA molecule are predicted by our theoretical approach for different aqueous electrolyte models. These findings suggest that ion counting experimental data should not be used alone to validate the performance of aqueous DNA-electrolyte models. PMID:25494770

  15. Volume and planar gated cardiac magnetic resonance imaging: a correlative study of normal anatomy with thallium-201 SPECT and cadaver sections

    SciTech Connect

    Go, R.T.; MacIntyre, W.J.; Yeung, H.N.; Kramer, D.M.; Geisinger, M.; Chilcote, W.; George, C.; O'Donnell, J.K.; Moodie, D.S.; Meaney, T.F.

    1984-01-01

    Magnetic resonance (MR) gated cardiac imaging was performed in ten subjects using a prototype 0.15-T resistive magnet imaging system. Volume and planar imaging techniques utilizing saturation recovery, proton Tl-weighted relaxation time pulse sequences produced images of the heart and great vessels with exquisite anatomic detail that showed excellent correlation with cadaver sections of the heart. The left ventricular myocardial segments also showed excellent correlation with the thallium-201 cardiac single photon emission computed tomography images. Volume acquisition allowed postprocessing selection of tomographic sections in various orientations to optimize visualization of a particular structure of interest. The excellent spatial and contrast resolution afforded by MR volume imaging, which does not involve the use of ionizing radiation and iodinated contrast material, should assure it a significant role in the diagnostic assessment of the cardiovascular system.

  16. DECREASES IN VENTRICULAR VOLUME CORRELATE WITH DECREASES IN VENTRICULAR PRESSURE IN IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS PATIENTS WHO EXPERIENCED CLINICAL IMPROVEMENT AFTER IMPLANTATION WITH ADJUSTABLE VALVE SHUNTS

    PubMed Central

    McConnell, Kathleen A.; Zou, Kelly H.; Chabrerie, Alexandra V.; Bailey, Nancy Olsen; Black, Peter McL.

    2005-01-01

    OBJECTIVE: This retrospective study examined whether changes in ventricular volume correspond with changes in adjustable valve pressure settings in a cohort of patients who received shunts to treat idiopathic normal pressure hydrocephalus. We also examined whether these pressure—volume curves and other patient variables would co-occur with a positive clinical response to shunting. METHODS: We selected 51 patients diagnosed with idiopathic normal pressure hydrocephalus who had undergone implantation of a Codman Hakim programmable valve (Medos S.A., Le Locle, Switzerland). Clinical data were gathered from the patients’ records and clinical notes by an investigator blinded to patients’ ventricular volumes. Ventricular volume was measured using 3D Slicer, an image analysis and interactive visualization software package developed and maintained at the Surgical Planning Laboratory at Brigham and Women’s Hospital. RESULTS: Eighty-six percent of patients with gait disturbance at presentation showed improvement of this symptom, 70% experienced improvement in incontinence, and 69% experienced improvement in dementia. For the group showing 100% clinical improvement, the correlation coefficient of average changes in valve pressure over time (ΔP/ΔT) and average changes in ventricular volume over time (ΔV/ΔT) were high at 0.843 (P < 0.05). For the group experiencing no or only partial improvement, the correlation coefficient was 0.257 (P = 0.32), indicating no correlation between average ΔV/ΔT and average ΔP/ΔT for each patient. CONCLUSION: This was a carefully analyzed modeling study of idiopathic normal pressure hydrocephalus treatment made possible only by adjustable valve technology. With careful volumetric analysis, we found that changes in ventricular volume correlated with adjustments in valve pressure settings for those patients who improved clinically after shunting. This suggests that positive clinical responders retained parenchymal elasticity

  17. Usability Evaluation of an Augmented Reality System for Teaching Euclidean Vectors

    ERIC Educational Resources Information Center

    Martin-Gonzalez, Anabel; Chi-Poot, Angel; Uc-Cetina, Victor

    2016-01-01

    Augmented reality (AR) is one of the emerging technologies that has demonstrated to be an efficient technological tool to enhance learning techniques. In this paper, we describe the development and evaluation of an AR system for teaching Euclidean vectors in physics and mathematics. The goal of this pedagogical tool is to facilitate user's…

  18. An orbit analysis approach to the study of superintegrable systems in the Euclidean plane

    SciTech Connect

    Adlam, C. M. McLenaghan, R. G. Smirnov, R. G.

    2007-03-15

    We classify the superintegrable potentials in the Euclidean plane by means of an orbit analysis of the space of valence two Killing tensors under the action of the group of rigid motions. Our approach generalizes the classical approach of Winternitz and collaborators by considering pairs of Killing tensors that are not both in canonical form.

  19. Perceptual or Analytical Processing? Evidence from Children's and Adult's Performance on the Euclidean Traveling Salesperson Problem

    ERIC Educational Resources Information Center

    van Rooij, Iris; Schactman, Alissa; Kadlec, Helena; Stege, Ulrike

    2006-01-01

    The Euclidean Traveling Salesperson Problem (E-TSP) is a useful task to study how humans optimize when faced with computational intractability. It has been found that humans are capable of finding high-quality solutions for E-TSP in a relatively short time and with seemingly little cognitive effort. This observation has led to two general…

  20. On the sequences ri, si, ti ∈ ℤ related to extended Euclidean algorithm and continued fractions

    NASA Astrophysics Data System (ADS)

    Muhammad, Khairun Nisak; Kamarulhaili, Hailiza

    2016-06-01

    The extended Euclidean Algorithm is a practical technique used in many cryptographic applications, where it computes the sequences ri, si, ti ∈ ℤ that always satisfy ri = si a+ tib. The integer ri is the remainder in the ith sequences. The sequences si and ti arising from the extended Euclidean algorithm are equal, up to sign, to the convergents of the continued fraction expansion of a/b. The values of (ri, si, ti) satisfy various properties which are used to solve the shortest vector problem in representing point multiplications in elliptic curves cryptography, namely the GLV (Gallant, Lambert & Vanstone) integer decomposition method and the ISD (integer sub decomposition) method. This paper is to extend the proof for each of the existing properties on (ri, si, ti). We also generate new properties which are relevant to the sequences ri, si, ti ∈ ℤ. The concepts of Euclidean algorithm, extended Euclidean algorithm and continued fractions are intertwined and the properties related to these concepts are proved. These properties together with the existing properties of the sequence (ri, si, ti) are regarded as part and parcel of the building blocks of a new generation of an efficient cryptographic protocol.

  1. Ab-initio reconstruction of complex Euclidean networks in two dimensions.

    PubMed

    Gujarathi, S R; Farrow, C L; Glosser, C; Granlund, L; Duxbury, P M

    2014-05-01

    Reconstruction of complex structures is an inverse problem arising in virtually all areas of science and technology, from protein structure determination to bulk heterostructure solar cells and the structure of nanoparticles. We cast this problem as a complex network problem where the edges in a network have weights equal to the Euclidean distance between their endpoints. We present a method for reconstruction of the locations of the nodes of the network given only the edge weights of the Euclidean network. The theoretical foundations of the method are based on rigidity theory, which enables derivation of a polynomial bound on its efficiency. An efficient implementation of the method is discussed and timing results indicate that the run time of the algorithm is polynomial in the number of nodes in the network. We have reconstructed Euclidean networks of about 1000 nodes in approximately 24 h on a desktop computer using this implementation. We also reconstruct Euclidean networks corresponding to polymer chains in two dimensions and planar graphene nanoparticles. We have also modified our base algorithm so that it can successfully solve random point sets when the input data are less precise.

  2. Thinking Outside the Euclidean Box: Riemannian Geometry and Inter-Temporal Decision-Making.

    PubMed

    Mishra, Himanshu; Mishra, Arul

    2016-01-01

    Inter-temporal decisions involves assigning values to various payoffs occurring at different temporal distances. Past research has used different approaches to study these decisions made by humans and animals. For instance, considering that people discount future payoffs at a constant rate (e.g., exponential discounting) or at variable rate (e.g., hyperbolic discounting). In this research, we question the widely assumed, but seldom questioned, notion across many of the existing approaches that the decision space, where the decision-maker perceives time and monetary payoffs, is a Euclidean space. By relaxing the rigid assumption of Euclidean space, we propose that the decision space is a more flexible Riemannian space of Constant Negative Curvature. We test our proposal by deriving a discount function, which uses the distance in the Negative Curvature space instead of Euclidean temporal distance. The distance function includes both perceived values of time as well as money, unlike past work which has considered just time. By doing so we are able to explain many of the empirical findings in inter-temporal decision-making literature. We provide converging evidence for our proposal by estimating the curvature of the decision space utilizing manifold learning algorithm and showing that the characteristics (i.e., metric properties) of the decision space resembles those of the Negative Curvature space rather than the Euclidean space. We conclude by presenting new theoretical predictions derived from our proposal and implications for how non-normative behavior is defined.

  3. Perceptual or Analytical Processing? Evidence from Children's and Adult's Performance on the Euclidean Traveling Salesperson Problem

    ERIC Educational Resources Information Center

    van Rooij, Iris; Schactman, Alissa; Kadlec, Helena; Stege, Ulrike

    2006-01-01

    The Euclidean Traveling Salesperson Problem (E-TSP) is a useful task to study how humans optimize when faced with computational intractability. It has been found that humans are capable of finding high-quality solutions for E-TSP in a relatively short time and with seemingly little cognitive effort. This observation has led to two general…

  4. Usability Evaluation of an Augmented Reality System for Teaching Euclidean Vectors

    ERIC Educational Resources Information Center

    Martin-Gonzalez, Anabel; Chi-Poot, Angel; Uc-Cetina, Victor

    2016-01-01

    Augmented reality (AR) is one of the emerging technologies that has demonstrated to be an efficient technological tool to enhance learning techniques. In this paper, we describe the development and evaluation of an AR system for teaching Euclidean vectors in physics and mathematics. The goal of this pedagogical tool is to facilitate user's…

  5. Thinking Outside the Euclidean Box: Riemannian Geometry and Inter-Temporal Decision-Making

    PubMed Central

    2016-01-01

    Inter-temporal decisions involves assigning values to various payoffs occurring at different temporal distances. Past research has used different approaches to study these decisions made by humans and animals. For instance, considering that people discount future payoffs at a constant rate (e.g., exponential discounting) or at variable rate (e.g., hyperbolic discounting). In this research, we question the widely assumed, but seldom questioned, notion across many of the existing approaches that the decision space, where the decision-maker perceives time and monetary payoffs, is a Euclidean space. By relaxing the rigid assumption of Euclidean space, we propose that the decision space is a more flexible Riemannian space of Constant Negative Curvature. We test our proposal by deriving a discount function, which uses the distance in the Negative Curvature space instead of Euclidean temporal distance. The distance function includes both perceived values of time as well as money, unlike past work which has considered just time. By doing so we are able to explain many of the empirical findings in inter-temporal decision-making literature. We provide converging evidence for our proposal by estimating the curvature of the decision space utilizing manifold learning algorithm and showing that the characteristics (i.e., metric properties) of the decision space resembles those of the Negative Curvature space rather than the Euclidean space. We conclude by presenting new theoretical predictions derived from our proposal and implications for how non-normative behavior is defined. PMID:27018787

  6. Correlation between Volume of Apical Periodontitis Determined by Cone-beam Computed Tomography Analysis and Endotoxin Levels Found in Primary Root Canal Infection.

    PubMed

    Cardoso, Flávia G R; Ferreira, Nádia S; Martinho, Frederico C; Nascimento, Gustavo G; Manhães, Luiz R C; Rocco, Marco A; Carvalho, Cláudio A T; Valera, Marcia C

    2015-07-01

    This clinical study was conducted to correlate the levels of endotoxins and bacterial counts found in primary endodontic infection with the volume of periapical bone destruction determined by cone-beam computed tomography (CBCT) analysis. Moreover, the levels of bacteria and endotoxins were correlated with the development of clinical features. Twenty-four root canals with primary endodontic disease and apical periodontitis were selected. Clinical features such as pain on palpation, pain on percussion, and previous episode of pain were recorded. The volume (cubic millimeters) of periapical bone destruction was determined by CBCT analysis. Endotoxins and bacterial samplings were collected by using sterile/apyrogenic paper points. Endotoxins were quantified by using limulus amebocyte lysate assay (KQCL test), and bacterial count (colony-forming units [CFU]/mL) was determined by using anaerobic culture techniques. Data were analyzed by Pearson correlation and multiple logistic regression (P < .05). Endotoxins and bacteria were detected in 100% of the root canal samples (24 of 24), with median values of 10.92 endotoxin units (EU)/mL (1.75-128 EU/mL) and 7.5 × 10(5) CFU/mL (3.20 × 10(5)-8.16 × 10(6) CFU/mL), respectively. The median volume of bone destruction determined by CBCT analysis was 100 mm(3) (10-450 mm(3)). The multiple regression analysis revealed a positive correlation between higher levels of endotoxins present in root canal infection and larger volume of bone destruction (P < .05). Moreover, higher levels of endotoxins were also correlated with the presence of previous pain (P < .05). Our findings revealed that the levels of endotoxins found in root canal infection are related to the volume of periapical bone destruction determined by CBCT analysis. Moreover, the levels of endotoxin are related to the presence of previous pain. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  7. Three-dimensional local measurements of bone strain and displacement: comparison of three digital volume correlation approaches.

    PubMed

    Palanca, Marco; Tozzi, Gianluca; Cristofolini, Luca; Viceconti, Marco; Dall'Ara, Enrico

    2015-07-01

    Different digital volume correlation (DVC) approaches are currently available or under development for bone tissue micromechanics. The aim of this study was to compare accuracy and precision errors of three DVC approaches for a particular three-dimensional (3D) zero-strain condition. Trabecular and cortical bone specimens were repeatedly scanned with a micro-computed tomography (CT). The errors affecting computed displacements and strains were extracted for a known virtual translation, as well as for repeated scans. Three DVC strategies were tested: two local approaches, based on fast-Fourier-transform (DaVis-FFT) or direct-correlation (DaVis-DC), and a global approach based on elastic registration and a finite element (FE) solver (ShIRT-FE). Different computation subvolume sizes were tested. Much larger errors were found for the repeated scans than for the virtual translation test. For each algorithm, errors decreased asymptotically for larger subvolume sizes in the range explored. Considering this particular set of images, ShIRT-FE showed an overall better accuracy and precision (a few hundreds microstrain for a subvolume of 50 voxels). When the largest subvolume (50-52 voxels) was applied to cortical bone, the accuracy error obtained for repeated scans with ShIRT-FE was approximately half of that for the best local approach (DaVis-DC). The difference was lower (250 microstrain) in the case of trabecular bone. In terms of precision, the errors shown by DaVis-DC were closer to the ones computed by ShIRT-FE (differences of 131 microstrain and 157 microstrain for cortical and trabecular bone, respectively). The multipass computation available for DaVis software improved the accuracy and precision only for the DaVis-FFT in the virtual translation, particularly for trabecular bone. The better accuracy and precision of ShIRT-FE, followed by DaVis-DC, were obtained with a higher computational cost when compared to DaVis-FFT. The results underline the importance of

  8. Characterization of the bone-metal implant interface by Digital Volume Correlation of in-situ loading using neutron tomography.

    PubMed

    Le Cann, Sophie; Tudisco, Erika; Perdikouri, Christina; Belfrage, Ola; Kaestner, Anders; Hall, Stephen; Tägil, Magnus; Isaksson, Hanna

    2017-07-01

    Metallic implants are commonly used as surgical treatments for many orthopedic conditions. The long-term stability of implants relies on an adequate integration with the surrounding bone. Unsuccessful integration could lead to implant loosening. By combining mechanical loading with high-resolution 3D imaging methods, followed by image analysis such as Digital Volume Correlation (DVC), we aim at evaluating ex vivo the mechanical resistance of newly formed bone at the interface. X-rays tomography is commonly used to image bone but induces artefacts close to metallic components. Utilizing a different interaction with matter, neutron tomography is a promising alternative but has not yet been used in studies of bone mechanics. This work demonstrates that neutron tomography during in situ loading is a feasible tool to characterize the mechanical response of bone-implant interfaces, especially when combined with DVC. Experiments were performed where metal screws were implanted in rat tibiae during 4 weeks. The screws were pulled-out while the samples were sequentially imaged in situ with neutron tomography. The images were analyzed to quantify bone ingrowth around the implants. DVC was used to track the internal displacements and calculate the strain fields in the bone during loading. The neutron images were free of metal-related artefacts, which enabled accurate quantification of bone ingrowth on the screw (ranging from 60% to 71%). DVC allowed successful identification of the deformation and cracks that occurred during mechanical loading and led to final failure of the bone-implant interface. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Water-soluble gases as partitioning tracers to investigate the pore volume?transmissivity correlation in a fracture

    NASA Astrophysics Data System (ADS)

    Lunati, Ivan; Kinzelbach, Wolfgang

    2004-11-01

    Hydraulically equivalent fractures may show striking differences when a gas-migration experiment is performed because of the different correlations between transmissivity, pore volume and entry pressure. We numerically simulate gas migration between injection and extraction boreholes in a parallel plate fracture with a heterogeneous fault gouge, in a rough-walled fracture filled with homogeneous material, and in a rough-walled empty fracture. The parallel plate model and the empty model clearly show the existence of preferential paths; for high variance of the transmissivity field, gas flow takes place only in few discrete channels separated by water-saturated regions. In contrast, in the fracture filled with homogeneous fault gouge, the gas saturation is continuous and more uniformly distributed. It appears a fundamental issue to be able to discriminate in situ among conceptual models that can yield such a different gas-saturation distribution. As in practice, the saturation distribution cannot be directly observed, tracer experiments are performed to characterize a fracture. For these reasons, we simulate the transport of tracers, which are added to the gas phase as soon as quasi-steady saturation distribution and extraction rate are achieved, and we compare the breakthrough curves obtained assuming different models. Our numerical simulations suggest that discrimination among the models on the basis of single-tracer tests is unlikely. A better tool to investigate fracture properties is provided by a gas-tracer test, in which a cocktail of gases with different water solubility is employed. These gases behave as partitioning tracers and allow us to estimate the gas saturation in the fracture. Indeed, by comparison of the residence-time distributions of different gases, we are able to compute a streamline effective saturation, which is an excellent estimate of fracture saturation. In addition, the streamline effective saturation curve contains information that is

  10. Periadolescent ethanol vapor exposure produces reductions in hippocampal volume that are correlated with deficits in prepulse inhibition of the startle

    PubMed Central

    Ehlers, Cindy L.; Oguz, Ipek; Budin, Francois; Wills, Derek N.; Crews, Fulton T.

    2013-01-01

    BACKGROUND Epidemiological studies suggest that excessive alcohol consumption is prevalent among adolescents and may have lasting neurobehavioral consequences. The use of animal models allows for the separation of the effects of adolescent ethanol exposure from genetic background and other environmental insults. In the present study the effects of moderate ethanol vapor exposure, during adolescence, on structural diffusion tensor imaging (DTI) and behavioral measures were evaluated in adulthood. METHODS A total of 53 Wistar rats were received at postnatal day (PD) 21, and were randomly assigned to ethanol vapor (14 hrs on/10 hrs off/day) or air exposure for 35 days from PD 23-PD 58 (average blood ethanol concentration (BEC): 169 mg%). Animals were received in two groups that were subsequently sacrificed at two time points following withdrawal from ethanol vapor: (1) at 72 days of age, 2 weeks following withdrawal or (2) at day 128, 10 weeks following withdrawal. In the second group, behavior in the light/dark box and prepulse inhibition of the startle (PPI) were also evaluated. Fifteen animals in each group were scanned, post mortem, for structural DTI. RESULTS There were no significant differences in body weight between ethanol and control animals. Volumetric data, demonstrated that total brain, hippocampal, corpus callosum but not ventricular volume was significantly larger in the 128 day sacrificed animals as compared to the 72 day animals. The hippocampus was smaller and the ventricles larger at 128 days as compared to 72 days, in the ethanol exposed animals, leading to a significant group × time effect. Ethanol exposed animals sacrificed at 128 days also had diminished PPI and more rears in the light box that were significantly correlated with hippocampal size. CONCLUSIONS These studies demonstrate that DTI volumetric measures of hippocampus are significantly impacted by age and periadolescent ethanol exposure and withdrawal in Wistar rats. PMID:23578102

  11. Multipolar radiofrequency ablation using internally cooled electrodes in ex vivo bovine liver: correlation between volume of coagulation and amount of applied energy.

    PubMed

    Clasen, Stephan; Rempp, Hansjörg; Schmidt, Diethard; Schraml, Christina; Hoffmann, Rüdiger; Claussen, Claus D; Pereira, Philippe L

    2012-01-01

    To evaluate the relationship between applied energy and volume of coagulation induced by multipolar radiofrequency (RF) ablation. Multipolar RF ablations (n=80) were performed in ex vivo bovine liver. Three bipolar applicators with two electrodes located on each applicator shaft were placed in a triangular array. The power-output (75-225 W) and the distance between the different applicators (2, 3, 4, 5 cm) were systematically varied. The volume of confluent white coagulation and the amount of applied energy were assessed. Based on our experimental data the relationship between the volume of coagulation and applied energy was assessed by nonlinear regression analysis. The variability explained by the model was determined by the parameter r(2). The volume of coagulation increases with higher amounts of applied energy. The maximum amount of energy was applied at a power-output of 75 W and an applicator distance of 5 cm. The corresponding maximum volume of coagulation was 324 cm(3) and required an application of 453 kJ. The relationship between amount of applied energy (E) and volume (V) of coagulation can be described by the function, V=4.39E(0.7) (r(2)=0.88). By approximation the volume of coagulation can be calculated by the linear function V=0.61E+40.7 (r(2)=0.87). Ex vivo the relationship between volume of coagulation and amount of applied energy can be described by mathematical modeling. The amount of applied energy correlates to the volume of coagulation and may be a useful parameter to monitor multipolar RF ablation. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  12. Differences in cognitive ability and hippocampal volume between Alzheimer's disease, amnestic mild cognitive impairment, and healthy control groups, and their correlation.

    PubMed

    Choi, Mi-Hyun; Kim, Hyung-Sik; Gim, Seon-Young; Kim, Woo-Ram; Mun, Kyung-Ryul; Tack, Gye-Rae; Lee, Bongsoo; Choi, Young Chil; Kim, Hyun-Jun; Hong, Seung Hwa; Lim, Dae-Woon; Chung, Soon-Cheol

    2016-05-04

    The study investigated differences in cognitive ability and hippocampal volume between groups of patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), and healthy control (HC) subjects, and explored the relationship between cognitive ability and hippocampal volume. Among the sub-tests of Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K), the Boston naming test score decreased in the order HC, aMCI, and AD. The hippocampal volumes of subjects with AD and aMCI were relatively smaller than those of HC individuals. There were strongly positive correlations between hippocampal volume and the scores for the Boston naming test. Discriminant analysis identified the Boston naming test as having the highest level of discrimination among the variables used to differentiate the three groups (89.9%). In conclusion, the Boston naming test accurately differentiated the three groups and was correlated with hippocampal volume. These results will be helpful for choosing an accurate and economically feasible test method that efficiently differentiates the three groups. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  13. Alterations in white matter volume and its correlation with neuropsychological scales in patients with Alzheimer's disease: a DARTEL-based voxel-based morphometry study.

    PubMed

    Moon, Chung-Man; Shin, Il-Seon; Jeong, Gwang-Woo

    2017-02-01

    Background Non-invasive imaging markers can be used to diagnose Alzheimer's disease (AD) in its early stages, but an optimized quantification analysis to measure the brain integrity has been less studied. Purpose To evaluate white matter volume change and its correlation with neuropsychological scales in patients with AD using a diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL)-based voxel-based morphometry (VBM). Material and Methods The 21 participants comprised 11 patients with AD and 10 age-matched healthy controls. High-resolution magnetic resonance imaging (MRI) data were processed by VBM analysis based on DARTEL algorithm. Results The patients showed significant white matter volume reductions in the posterior limb of the internal capsule, cerebral peduncle of the midbrain, and parahippocampal gyrus compared to healthy controls. In correlation analysis, the parahippocampal volume was positively correlated with the Korean-mini mental state examination score in AD. Conclusion This study provides an evidence for localized white matter volume deficits in conjunction with cognitive dysfunction in AD. These findings would be helpful to understand the neuroanatomical mechanisms in AD and to robust the diagnostic accuracy for AD.

  14. Linear and curvilinear correlations of brain gray matter volume and density with age using voxel-based morphometry with the Akaike information criterion in 291 healthy children.

    PubMed

    Taki, Yasuyuki; Hashizume, Hiroshi; Thyreau, Benjamin; Sassa, Yuko; Takeuchi, Hikaru; Wu, Kai; Kotozaki, Yuka; Nouchi, Rui; Asano, Michiko; Asano, Kohei; Fukuda, Hiroshi; Kawashima, Ryuta

    2013-08-01

    We examined linear and curvilinear correlations of gray matter volume and density in cortical and subcortical gray matter with age using magnetic resonance images (MRI) in a large number of healthy children. We applied voxel-based morphometry (VBM) and region-of-interest (ROI) analyses with the Akaike information criterion (AIC), which was used to determine the best-fit model by selecting which predictor terms should be included. We collected data on brain structural MRI in 291 healthy children aged 5-18 years. Structural MRI data were segmented and normalized using a custom template by applying the diffeomorphic anatomical registration using exponentiated lie algebra (DARTEL) procedure. Next, we analyzed the correlations of gray matter volume and density with age in VBM with AIC by estimating linear, quadratic, and cubic polynomial functions. Several regions such as the prefrontal cortex, the precentral gyrus, and cerebellum showed significant linear or curvilinear correlations between gray matter volume and age on an increasing trajectory, and between gray matter density and age on a decreasing trajectory in VBM and ROI analyses with AIC. Because the trajectory of gray matter volume and density with age suggests the progress of brain maturation, our results may contribute to clarifying brain maturation in healthy children from the viewpoint of brain structure.

  15. Strong Correlation of Upper-Extremity Blood-Flow Volume With Grip Strength While in a Provocative Shoulder Position in Baseball Pitchers.

    PubMed

    Laudner, Kevin; Vazquez, Jose; Selkow, Noelle; Meister, Keith

    2017-07-01

    Baseball players, specifically pitchers, with symptomatic neurovascular occlusion often initially complain of arm fatigue and loss of ball control and velocity. As the compression continues complaints may manifest in dull pain, paresthesia, and decreased grip strength. To determine the correlation between upper-extremity blood-flow volume and grip strength among baseball pitchers. Cross-sectional. Athletic training room. 66 professional baseball pitchers (age 21.6 ± 2.0 y, height 186.9 ± 5.7 cm, mass 91.3 ± 10.9 kg) before the start of spring training. Diagnostic ultrasound was used to measure upper-extremity blood-flow volume with the throwing shoulder in a resting position and in a provocative position. Grip strength was measured with participants seated and their throwing-arm elbow flexed to 90°. Pearson product-moment correlation coefficients were used to determine the strength of the relationships between blood-flow volume in the 2 arm positions and grip strength (P < .05). No significant relationship was found between blood-flow volume in the resting position and grip strength (r = .03, P = .81); however, a strong positive correlation was found in the 2nd provocative position (r = .67, P = .001). This relationship indicates that as blood-flow volume tested in a provocative shoulder position decreases, so does grip strength. A strong positive relationship was found in pitchers, demonstrating that as upper-extremity blood-flow volume while in the provocative shoulder position decreases, so does grip strength.

  16. Segmental bronchi collapsibility: computed tomography-based quantification in patients with chronic obstructive pulmonary disease and correlation with emphysema phenotype, corresponding lung volume changes and clinical parameters

    PubMed Central

    Thaiss, Wolfgang Maximilian; Ditt, Hendrik; Hetzel, Jürgen; Schülen, Eva; Nikolaou, Konstantin; Horger, Marius

    2016-01-01

    Background Global pulmonary function tests lack region specific differentiation that might influence therapy in severe chronic obstructive pulmonary disease (COPD) patients. Therefore, the aim of this work was to assess the degree of expiratory 3rd generation bronchial lumen collapsibility in patients with severe COPD using chest-computed tomography (CT), to evaluate emphysema-phenotype, lobar volumes and correlate results with pulmonary function tests. Methods Thin-slice chest-CTs acquired at end-inspiration & end-expiration in 42 COPD GOLD IV patients (19 females, median-age: 65.9 y) from November 2011 to July 2014 were re-evaluated. The cross-sectional area of all segmental bronchi was measured 5 mm below the bronchial origin in both examinations. Lung lobes were semi-automatically segmented, volumes calculated at end-inspiratory and end-expiratory phase and visually defined emphysema-phenotypes defined. Results of CT densitometry were compared with lung functional tests including forced expiratory volume at 1 s (FEV1), total lung capacity (TLC), vital capacity (VC), residual volume (RV), diffusion capacity parameters and the maximal expiratory flow rates (MEFs). Results Mean expiratory bronchial collapse was 31%, stronger in lobes with homogenous (38.5%) vs. heterogeneous emphysema-phenotype (27.8%, P=0.014). The mean lobar expiratory volume reduction was comparable in both emphysema-phenotypes (volume reduction 18.6%±8.3% in homogenous vs. 17.6%±16.5% in heterogeneous phenotype). The degree of bronchial lumen collapsibility, did not correlate with expiratory volume reduction. MEF25 correlated weakly with 3rd generation airway collapsibility (r=0.339, P=0.03). All patients showed a concentric expiratory reduction of bronchial cross-sectional area. Conclusions Changes in collapsibility of 3rd generation bronchi in COPD grade IV patients is significantly lower than that in the trachea and the main bronchi. Collapsibility did not correlate with the reduction in

  17. Distinct structural neural patterns of trait physical and social anhedonia: evidence from cortical thickness, subcortical volumes and inter-regional correlations.

    PubMed

    Wang, Yi; Deng, Yi; Fung, Germaine; Liu, Wen-hua; Wei, Xin-hua; Jiang, Xin-qing; Lui, Simon S Y; Cheung, Eric F C; Chan, Raymond C K

    2014-12-30

    Anhedonia is an enduring trait accounting for the reduced capacity to experience pleasure. Few studies have investigated the brain structural features associated with trait anhedonia. In this study, the relationships between cortical thickness, volume of subcortical structures and scores on the Chapman physical and social anhedonia scales were examined in a non-clinical sample (n=72, 35 males). FreeSurfer was used to examine the cortical thickness and the volume of six identified subcortical structures related to trait anhedonia. We found that the cortical thickness of the superior frontal gyrus and the volume of the pallidum in the left hemisphere were correlated with anhedonia scores in both physical and social aspects. Specifically, positive correlations were found between levels of social anhedonia and the thickness of the postcentral and the inferior parietal gyri. Cortico-subcortical inter-correlations between these clusters were also observed. Our findings revealed distinct correlation patterns of neural substrates with trait physical and social anhedonia in a non-clinical sample. These findings contribute to the understanding of the pathologies underlying the anhedonia phenotype in schizophrenia and other psychiatric disorders.

  18. Apoptotic markers in cultured fibroblasts correlate with brain metabolites and regional brain volume in antipsychotic-naive first-episode schizophrenia and healthy controls.

    PubMed

    Batalla, A; Bargalló, N; Gassó, P; Molina, O; Pareto, D; Mas, S; Roca, J M; Bernardo, M; Lafuente, A; Parellada, E

    2015-08-25

    Cultured fibroblasts from first-episode schizophrenia patients (FES) have shown increased susceptibility to apoptosis, which may be related to glutamate dysfunction and progressive neuroanatomical changes. Here we determine whether apoptotic markers obtained from cultured fibroblasts in FES and controls correlate with changes in brain glutamate and N-acetylaspartate (NAA) and regional brain volumes. Eleven antipsychotic-naive FES and seven age- and gender-matched controls underwent 3-Tesla magnetic resonance imaging scanning. Glutamate plus glutamine (Glx) and NAA levels were measured in the anterior cingulate (AC) and the left thalamus (LT). Hallmarks of apoptotic susceptibility (caspase-3-baseline activity, phosphatidylserine externalization and chromatin condensation) were measured in fibroblast cultures obtained from skin biopsies after inducing apoptosis with staurosporine (STS) at doses of 0.25 and 0.5 μM. Apoptotic biomarkers were correlated to brain metabolites and regional brain volume. FES and controls showed a negative correlation in the AC between Glx levels and percentages of cells with condensed chromatin (CC) after both apoptosis inductions (STS 0.5 μM: r = -0.90; P = 0.001; STS 0.25 μM: r = -0.73; P = 0.003), and between NAA and cells with CC (STS 0.5 μM induction r = -0.76; P = 0.002; STS 0.25 μM r = -0.62; P = 0.01). In addition, we found a negative correlation between percentages of cells with CC and regional brain volume in the right supratemporal cortex and post-central region (STS 0.25 and 0.5 μM; P < 0.05 family-wise error corrected (FWEc)). We reveal for the first time that peripheral markers of apoptotic susceptibility may correlate with brain metabolites, Glx and NAA, and regional brain volume in FES and controls, which is consistent with the neuroprogressive theories around the onset of the schizophrenia illness.

  19. Regional brain volumes distinguish PSP, MSA-P, and PD: MRI-based clinico-radiological correlations.

    PubMed

    Paviour, Dominic C; Price, Shona L; Jahanshahi, Marjan; Lees, Andrew J; Fox, Nick C

    2006-07-01

    Progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are neurodegenerative disorders, each with a prevalence of around 5 per 100,000. Regional brain atrophy patterns differ in the two disorders, however, and magnetic resonance imaging is sometimes helpful in distinguishing them in the later stages. We measured whole brain and regional volumes, including cerebellum, pons, midbrain, superior cerebellar peduncle (SCP), and ventricular volumes as well as frontal and posterior-inferior cerebral regions in 18 subjects with PSP, 9 with MSA-P (parkinsonian phenotype), 9 with Parkinson's disease (PD), and 18 healthy controls. Associations between these volumes, cognitive profiles, and clinical measures of disease severity and motor disability were assessed. Mean midbrain volume was 30% smaller in PSP than in PD or controls (P < 0.001) and 15% smaller than in MSA-P (P = 0.009). The mean SCP volume in PSP was 30% smaller than in MSA-P, PD, or controls (P < 0.001). Mean cerebellar volumes in MSA-P were 20% smaller than in controls and PD and 18% smaller than in PSP (P = 0.01). Mean pontine volume in MSA-P was 30% smaller than in PD or controls (P < 0.001) and 25% smaller than in PSP (P = 0.01). Motor disability was most strongly associated with midbrain volume, and more severe executive dysfunction was associated with reduced frontal volume. These distinct patterns of cortical and subcortical atrophy, when considered together rather than independently, better differentiate PSP and MSA-P from each other and also from healthy controls.

  20. NOTE Thyroid volume measurement in external beam radiotherapy patients using CT imaging: correlation with clinical and anthropometric characteristics

    NASA Astrophysics Data System (ADS)

    Veres, C.; Garsi, J. P.; Rubino, C.; Pouzoulet, F.; Bidault, F.; Chavaudra, J.; Bridier, A.; Ricard, M.; Ferreira, I.; Lefkopoulos, D.; de Vathaire, F.; Diallo, I.

    2010-11-01

    The aim of this study is to define criteria for accurate representation of the thyroid in human models used to represent external beam radiotherapy (EBRT) patients and evaluate the relationship between the volume of this organ and clinical and anthropometric characteristics. From CT images, we segmented the thyroid gland and calculated its volume for a population of 188 EBRT patients of both sexes, with ages ranging from 1 to 89 years. To evaluate uncertainties linked to measured volumes, experimental studies on the Livermore anthropomorphic phantom were performed. For our population of EBRT patients, we observed that in children, thyroid volume increased rapidly with age, from about 3 cm3 at 2 years to about 16 cm3 at 20. In adults, the mean thyroid gland volume was 23.5 ± 9 cm3 for males and 17.5 ± 8 cm3 for females. According to anthropometric parameters, the best fit for children was obtained by modeling the log of thyroid volume as a linear function of body surface area (BSA) (p < 0.0001) and age (p = 0.04) and for adults, as a linear function of BSA (p < 0.0001) and gender (p = 0.01). This work enabled us to demonstrate that BSA was the best indicator of thyroid volume for both males and females. These results should be taken into account when modeling the volume of the thyroid in human models used to represent EBRT patients for dosimetry in retrospective studies of the relationship between the estimated dose to the thyroid and long-term follow-up data on EBRT patients.

  1. Correlating 2D histological slice with 3D MRI image volume using smart phone as an interactive tool for muscle study.

    PubMed

    Eresen, Aydin; Li, Peng; Ji, Jim Xiuquan

    2014-01-01

    In muscle dystrophy studies, registration of histological image with MRI image volume enables cross validation of MRI biomarkers using pathological result. However, correlation of 2D histology slice with 3D MRI volume is technically challenging due to the potentially non-orthogonal slice plane and incomplete or distorted histological slice. This paper presents an efficient method to directly perform the 2D-3D registration. The method is unique in that it uses smart phone as a navigation tool for initial alignment followed by an overlap invariant mutual information-based refinement. Experimental results using animal muscle samples images from a 3T MRI and HE stained histological images show that the proposed method is capable of aligning the histological slice with an oblique slice in MR volume.

  2. Impact of the radiotherapy technique on the correlation between dose-volume histograms of the bladder wall defined on MRI imaging and dose-volume/surface histograms in prostate cancer patients

    NASA Astrophysics Data System (ADS)

    Maggio, Angelo; Carillo, Viviana; Cozzarini, Cesare; Perna, Lucia; Rancati, Tiziana; Valdagni, Riccardo; Gabriele, Pietro; Fiorino, Claudio

    2013-04-01

    The aim of this study was to evaluate the correlation between the ‘true’ absolute and relative dose-volume histograms (DVHs) of the bladder wall, dose-wall histogram (DWH) defined on MRI imaging and other surrogates of bladder dosimetry in prostate cancer patients, planned both with 3D-conformal and intensity-modulated radiation therapy (IMRT) techniques. For 17 prostate cancer patients, previously treated with radical intent, CT and MRI scans were acquired and matched. The contours of bladder walls were drawn by using MRI images. External bladder surfaces were then used to generate artificial bladder walls by performing automatic contractions of 5, 7 and 10 mm. For each patient a 3D conformal radiotherapy (3DCRT) and an IMRT treatment plan was generated with a prescription dose of 77.4 Gy (1.8 Gy/fr) and DVH of the whole bladder of the artificial walls (DVH-5/10) and dose-surface histograms (DSHs) were calculated and compared against the DWH in absolute and relative value, for both treatment planning techniques. A specific software (VODCA v. 4.4.0, MSS Inc.) was used for calculating the dose-volume/surface histogram. Correlation was quantified for selected dose-volume/surface parameters by the Spearman correlation coefficient. The agreement between %DWH and DVH5, DVH7 and DVH10 was found to be very good (maximum average deviations below 2%, SD < 5%): DVH5 showed the best agreement. The correlation was slightly better for absolute (R = 0.80-0.94) compared to relative (R = 0.66-0.92) histograms. The DSH was also found to be highly correlated with the DWH, although slightly higher deviations were generally found. The DVH was not a good surrogate of the DWH (R < 0.7 for most of parameters). When comparing the two treatment techniques, more pronounced differences between relative histograms were seen for IMRT with respect to 3DCRT (p < 0.0001).

  3. Identification of myocardial diffuse fibrosis by 11 heartbeat MOLLI T 1 mapping: averaging to improve precision and correlation with collagen volume fraction.

    PubMed

    Vassiliou, Vassilios S; Wassilew, Katharina; Cameron, Donnie; Heng, Ee Ling; Nyktari, Evangelia; Asimakopoulos, George; de Souza, Anthony; Giri, Shivraman; Pierce, Iain; Jabbour, Andrew; Firmin, David; Frenneaux, Michael; Gatehouse, Peter; Pennell, Dudley J; Prasad, Sanjay K

    2017-06-12

    Our objectives involved identifying whether repeated averaging in basal and mid left ventricular myocardial levels improves precision and correlation with collagen volume fraction for 11 heartbeat MOLLI T 1 mapping versus assessment at a single ventricular level. For assessment of T 1 mapping precision, a cohort of 15 healthy volunteers underwent two CMR scans on separate days using an 11 heartbeat MOLLI with a 5(3)3 beat scheme to measure native T 1 and a 4(1)3(1)2 beat post-contrast scheme to measure post-contrast T 1, allowing calculation of partition coefficient and ECV. To assess correlation of T 1 mapping with collagen volume fraction, a separate cohort of ten aortic stenosis patients scheduled to undergo surgery underwent one CMR scan with this 11 heartbeat MOLLI scheme, followed by intraoperative tru-cut myocardial biopsy. Six models of myocardial diffuse fibrosis assessment were established with incremental inclusion of imaging by averaging of the basal and mid-myocardial left ventricular levels, and each model was assessed for precision and correlation with collagen volume fraction. A model using 11 heart beat MOLLI imaging of two basal and two mid ventricular level averaged T 1 maps provided improved precision (Intraclass correlation 0.93 vs 0.84) and correlation with histology (R (2) = 0.83 vs 0.36) for diffuse fibrosis compared to a single mid-ventricular level alone. ECV was more precise and correlated better than native T 1 mapping. T 1 mapping sequences with repeated averaging could be considered for applications of 11 heartbeat MOLLI, especially when small changes in native T 1/ECV might affect clinical management.

  4. Retro-nasal aroma release is correlated with variations in the in-mouth air cavity volume after empty deglutition.

    PubMed

    Mishellany-Dutour, Anne; Woda, Alain; Labouré, Hélène; Bourdiol, Pierre; Lachaze, Pauline; Guichard, Elisabeth; Feron, Gilles

    2012-01-01

    We hypothesized that interindividual differences in motor activities during chewing and/or swallowing were determining factors for the transfer of volatile aroma from the in-mouth air cavity (IMAC) toward the olfactory mucosa. In our first experiment, we looked for changes in IMAC volume after saliva deglutition in 12 healthy subjects. The mean IMAC volume was measured after empty deglutition using an acoustic pharyngometer device. Based on the time course of the IMAC volume after swallowing, we discerned two groups of subjects. The first group displayed a small, constant IMAC volume (2.26 mL ±0.62) that corresponded to a high tongue position. The second group displayed a progressive increase in IMAC (from 6.82 mL ±2.37 to 22.82 mL ±3.04) that corresponded to a progressive lowering of the tongue to its resting position. In our second experiment, we investigated the relationship between IMAC volume changes after deglutition and the level of aroma release at the nostril. For this purpose, the release of menthone was measured at the nostril level in 25 subjects who consumed similar amounts of a mint tablet. The subjects were separated into two groups corresponding to two levels of menthone release: high (H) and low (L). The mean volume of IMAC was measured during and after empty deglutition. Group H displayed a small, constant amplitude of IMAC volume change after deglutition, while Group L displayed a progressive increase in IMAC. It is likely that Group H continuously released the aroma through the veloglossal isthmus as the mint was consumed, while Group L trapped the aroma in the oral cavity and then released it into the nasal cavity upon swallowing. These results show that the in vivo aroma release profile in humans depends closely on the different motor patterns at work during empty deglutition.

  5. Retro-Nasal Aroma Release Is Correlated with Variations in the In-Mouth Air Cavity Volume after Empty Deglutition

    PubMed Central

    Mishellany-Dutour, Anne; Woda, Alain; Labouré, Hélène; Bourdiol, Pierre; Lachaze, Pauline; Guichard, Elisabeth; Feron, Gilles

    2012-01-01

    We hypothesized that interindividual differences in motor activities during chewing and/or swallowing were determining factors for the transfer of volatile aroma from the in-mouth air cavity (IMAC) toward the olfactory mucosa. In our first experiment, we looked for changes in IMAC volume after saliva deglutition in 12 healthy subjects. The mean IMAC volume was measured after empty deglutition using an acoustic pharyngometer device. Based on the time course of the IMAC volume after swallowing, we discerned two groups of subjects. The first group displayed a small, constant IMAC volume (2.26 mL ±0.62) that corresponded to a high tongue position. The second group displayed a progressive increase in IMAC (from 6.82 mL ±2.37 to 22.82 mL ±3.04) that corresponded to a progressive lowering of the tongue to its resting position. In our second experiment, we investigated the relationship between IMAC volume changes after deglutition and the level of aroma release at the nostril. For this purpose, the release of menthone was measured at the nostril level in 25 subjects who consumed similar amounts of a mint tablet. The subjects were separated into two groups corresponding to two levels of menthone release: high (H) and low (L). The mean volume of IMAC was measured during and after empty deglutition. Group H displayed a small, constant amplitude of IMAC volume change after deglutition, while Group L displayed a progressive increase in IMAC. It is likely that Group H continuously released the aroma through the veloglossal isthmus as the mint was consumed, while Group L trapped the aroma in the oral cavity and then released it into the nasal cavity upon swallowing. These results show that the in vivo aroma release profile in humans depends closely on the different motor patterns at work during empty deglutition. PMID:22815986

  6. Tracking the roots of reading ability: white matter volume and integrity correlate with phonological awareness in prereading and early-reading kindergarten children.

    PubMed

    Saygin, Zeynep M; Norton, Elizabeth S; Osher, David E; Beach, Sara D; Cyr, Abigail B; Ozernov-Palchik, Ola; Yendiki, Anastasia; Fischl, Bruce; Gaab, Nadine; Gabrieli, John D E

    2013-08-14

    Developmental dyslexia, an unexplained difficulty in learning to read, has been associated with alterations in white matter organization as measured by diffusion-weighted imaging. It is unknown, however, whether these differences in structural connectivity are related to the cause of dyslexia or if they are consequences of reading difficulty (e.g., less reading experience or compensatory brain organization). Here, in 40 kindergartners who had received little or no reading instruction, we examined the relation between behavioral predictors of dyslexia and white matter organization in left arcuate fasciculus, inferior longitudinal fasciculus, and the parietal portion of the superior longitudinal fasciculus using probabilistic tractography. Higher composite phonological awareness scores were significantly and positively correlated with the volume of the arcuate fasciculus, but not with other tracts. Two other behavioral predictors of dyslexia, rapid naming and letter knowledge, did not correlate with volumes or diffusion values in these tracts. The volume and fractional anisotropy of the left arcuate showed a particularly strong positive correlation with a phoneme blending test. Whole-brain regressions of behavioral scores with diffusion measures confirmed the unique relation between phonological awareness and the left arcuate. These findings indicate that the left arcuate fasciculus, which connects anterior and posterior language regions of the human brain and which has been previously associated with reading ability in older individuals, is already smaller and has less integrity in kindergartners who are at risk for dyslexia because of poor phonological awareness. These findings suggest a structural basis of behavioral risk for dyslexia that predates reading instruction.

  7. A Low-Complexity Euclidean Orthogonal LDPC Architecture for Low Power Applications

    PubMed Central

    Revathy, M.; Saravanan, R.

    2015-01-01

    Low-density parity-check (LDPC) codes have been implemented in latest digital video broadcasting, broadband wireless access (WiMax), and fourth generation of wireless standards. In this paper, we have proposed a high efficient low-density parity-check code (LDPC) decoder architecture for low power applications. This study also considers the design and analysis of check node and variable node units and Euclidean orthogonal generator in LDPC decoder architecture. The Euclidean orthogonal generator is used to reduce the error rate of the proposed LDPC architecture, which can be incorporated between check and variable node architecture. This proposed decoder design is synthesized on Xilinx 9.2i platform and simulated using Modelsim, which is targeted to 45 nm devices. Synthesis report proves that the proposed architecture greatly reduces the power consumption and hardware utilizations on comparing with different conventional architectures. PMID:26065017

  8. Padé approximants and analytic continuation of Euclidean Φ -derivable approximations

    NASA Astrophysics Data System (ADS)

    Markó, Gergely; Reinosa, Urko; Szép, Zsolt

    2017-08-01

    We investigate the Padé approximation method for the analytic continuation of numerical data and its ability to access, from the Euclidean propagator, both the spectral function and part of the physical information hidden in the second Riemann sheet. We test this method using various benchmarks at zero temperature: a simple perturbative approximation as well as the two-loop Φ -derivable approximation. The analytic continuation method is then applied to Euclidean data previously obtained in the O (4 ) symmetric model (within a given renormalization scheme) to assess the difference between zero-momentum and pole masses, which is in general a difficult question to answer within nonperturbative approaches such as the Φ -derivable expansion scheme.

  9. A Low-Complexity Euclidean Orthogonal LDPC Architecture for Low Power Applications.

    PubMed

    Revathy, M; Saravanan, R

    2015-01-01

    Low-density parity-check (LDPC) codes have been implemented in latest digital video broadcasting, broadband wireless access (WiMax), and fourth generation of wireless standards. In this paper, we have proposed a high efficient low-density parity-check code (LDPC) decoder architecture for low power applications. This study also considers the design and analysis of check node and variable node units and Euclidean orthogonal generator in LDPC decoder architecture. The Euclidean orthogonal generator is used to reduce the error rate of the proposed LDPC architecture, which can be incorporated between check and variable node architecture. This proposed decoder design is synthesized on Xilinx 9.2i platform and simulated using Modelsim, which is targeted to 45 nm devices. Synthesis report proves that the proposed architecture greatly reduces the power consumption and hardware utilizations on comparing with different conventional architectures.

  10. Parameterized runtime analyses of evolutionary algorithms for the planar euclidean traveling salesperson problem.

    PubMed

    Sutton, Andrew M; Neumann, Frank; Nallaperuma, Samadhi

    2014-01-01

    Parameterized runtime analysis seeks to understand the influence of problem structure on algorithmic runtime. In this paper, we contribute to the theoretical understanding of evolutionary algorithms and carry out a parameterized analysis of evolutionary algorithms for the Euclidean traveling salesperson problem (Euclidean TSP). We investigate the structural properties in TSP instances that influence the optimization process of evolutionary algorithms and use this information to bound their runtime. We analyze the runtime in dependence of the number of inner points k. In the first part of the paper, we study a [Formula: see text] EA in a strictly black box setting and show that it can solve the Euclidean TSP in expected time [Formula: see text] where A is a function of the minimum angle [Formula: see text] between any three points. Based on insights provided by the analysis, we improve this upper bound by introducing a mixed mutation strategy that incorporates both 2-opt moves and permutation jumps. This strategy improves the upper bound to [Formula: see text]. In the second part of the paper, we use the information gained in the analysis to incorporate domain knowledge to design two fixed-parameter tractable (FPT) evolutionary algorithms for the planar Euclidean TSP. We first develop a [Formula: see text] EA based on an analysis by M. Theile, 2009, "Exact solutions to the traveling salesperson problem by a population-based evolutionary algorithm," Lecture notes in computer science, Vol. 5482 (pp. 145-155), that solves the TSP with k inner points in [Formula: see text] generations with probability [Formula: see text]. We then design a [Formula: see text] EA that incorporates a dynamic programming step into the fitness evaluation. We prove that a variant of this evolutionary algorithm using 2-opt mutation solves the problem after [Formula: see text] steps in expectation with a cost of [Formula: see text] for each fitness evaluation.

  11. Geometric properties of the magnetic Laplacian on the Euclidean 4-space

    SciTech Connect

    Kazmierowski, Dominique; Zinoun, Azzouz; Intissar, Ahmed

    2010-12-15

    When the four-dimensional Euclidean space is endowed with a covariant derivative that is either self-dual or antiself-dual and of constant curvature, the corresponding magnetic Laplacian is closely related to the sub-Laplacian of the quaternionic Heisenberg group. Some geometric properties of this operator are studied. In particular, it is proved that there exists a canonical orthogonal complex structure which provides a factorization in the sense of Schroedinger.

  12. ETEA: a Euclidean minimum spanning tree-based evolutionary algorithm for multi-objective optimization.

    PubMed

    Li, Miqing; Yang, Shengxiang; Zheng, Jinhua; Liu, Xiaohui

    2014-01-01

    The Euclidean minimum spanning tree (EMST), widely used in a variety of domains, is a minimum spanning tree of a set of points in space where the edge weight between each pair of points is their Euclidean distance. Since the generation of an EMST is entirely determined by the Euclidean distance between solutions (points), the properties of EMSTs have a close relation with the distribution and position information of solutions. This paper explores the properties of EMSTs and proposes an EMST-based evolutionary algorithm (ETEA) to solve multi-objective optimization problems (MOPs). Unlike most EMO algorithms that focus on the Pareto dominance relation, the proposed algorithm mainly considers distance-based measures to evaluate and compare individuals during the evolutionary search. Specifically, in ETEA, four strategies are introduced: (1) An EMST-based crowding distance (ETCD) is presented to estimate the density of individuals in the population; (2) A distance comparison approach incorporating ETCD is used to assign the fitness value for individuals; (3) A fitness adjustment technique is designed to avoid the partial overcrowding in environmental selection; (4) Three diversity indicators-the minimum edge, degree, and ETCD-with regard to EMSTs are applied to determine the survival of individuals in archive truncation. From a series of extensive experiments on 32 test instances with different characteristics, ETEA is found to be competitive against five state-of-the-art algorithms and its predecessor in providing a good balance among convergence, uniformity, and spread.

  13. Spectral asymptotics of Euclidean quantum gravity with diff-invariant boundary conditions

    NASA Astrophysics Data System (ADS)

    Esposito, Giampiero; Fucci, Guglielmo; Kamenshchik, Alexander Yu; Kirsten, Klaus

    2005-03-01

    A general method is known to exist for studying Abelian and non-Abelian gauge theories, as well as Euclidean quantum gravity, at 1-loop level on manifolds with boundary. In the latter case, boundary conditions on metric perturbations h can be chosen to be completely invariant under infinitesimal diffeomorphisms, to preserve the invariance group of the theory and BRST symmetry. In the de Donder gauge, however, the resulting boundary-value problem for the Laplace-type operator acting on h is known to be self-adjoint but not strongly elliptic. The latter is a technical condition ensuring that a unique smooth solution of the boundary-value problem exists, which implies, in turn, that the global heat-kernel asymptotics yielding 1-loop divergences and 1-loop effective action actually exists. The present paper shows that, on the Euclidean 4-ball, only the scalar part of perturbative modes for quantum gravity is affected by the lack of strong ellipticity. Further evidence for lack of strong ellipticity, from an analytic point of view, is therefore obtained. Interestingly, three sectors of the scalar-perturbation problem remain elliptic, while lack of strong ellipticity is 'confined' to the remaining fourth sector. The integral representation of the resulting ζ-function asymptotics on the Euclidean 4-ball is also obtained; this remains regular at the origin by virtue of a spectral identity here obtained for the first time.

  14. The Master Equations in the Euclidean Schwarzschild-Tangherlini Metric of a Small Static Perturbation

    NASA Astrophysics Data System (ADS)

    Martínez-Morales, José L.

    The master equations in the Euclidean Schwarzschild-Tangherlini space-time of a small static perturbation are studied. For each harmonic mode on the sphere there are two solutions that behave differently at infinity. One solution goes like the power 2-l-n of the radial variable, the other solution goes like the power l. These solutions occur in power series. The second main statement of the paper is that any eigentensor of the Lichnerowicz operator in a Euclidean Schwarzschild space-time with an eigenvalue different from zero is essentially singular at infinity. Possible applications of the stability of instantons are discussed. We present the analysis of a small static perturbation of the Euclidean Schwarzschild-Tangherlini metric tensor. The higher order perturbations will appear later. We determine independently the static perturbations of the Schwarzschild quantum black hole in dimension 1+n≥4, where the system of equations is reduced to master equations — ordinary differential equations. The solutions are hypergeometric functions which in some cases can be reduced to polynomials. In the same Schwarzschild background, we analyze static perturbations of the scalar mode and show that there does not exist any static perturbation that is regular everywhere outside the event horizon and is well-behaved at the spatial infinity. This confirms the uniqueness of the spherically symmetric static empty quantum black hole, within the perturbation framework. Our strategy for treating the stability problem is also applicable to other symmetric quantum black holes with a nonzero cosmological constant.

  15. Early post-operative weight loss after laparoscopic sleeve gastrectomy correlates with the volume of the excised stomach and not with that of the sleeve! Preliminary data from a multi-detector computed tomography-based study.

    PubMed

    Pawanindra, Lal; Vindal, Anubhav; Midha, Manoj; Nagpal, Prashant; Manchanda, Alpana; Chander, Jagdish

    2015-10-01

    Pre- and post-operative stomach volumes can be important determinants for effectiveness of laparoscopic sleeve gastrectomy (LSG) in causing weight loss. There is little existing data on the volumes of stomach preoperatively and that excised during LSG. This study was designed to evaluate the change in gastric volume after LSG using multi-detector CT and to correlate it with early post-operative weight loss. Twenty consecutive patients with BMI ≥ 40 kg/m(2) and medical comorbidities underwent LSG between October 2011 and October 2013 and were analysed prospectively. The pre-operative stomach volume was measured by MDCT done 1-3 days before the surgery. LSG was performed in the standard manner using a 36F bougie. The volume of excised stomach was measured by distending the specimen with saline. MDCT of the upper abdomen was repeated 3 months postoperatively to calculate the gastric sleeve volume. Weight loss and resolution of comorbidities were documented. The mean pre-operative weight of patients was 123.90 kg, and the mean pre-operative stomach volume on MDCT was 1,067 ml. The stomach volume on pre-operative MDCT correlated with pre-operative weight and BMI. The mean volume of the excised stomach was 859 ml when measured by distension of the specimen and 850 ml on MDCT. After 3 months post surgery, the mean volume of gastric sleeve on MDCT was 217 ml, and the mean weight of the patients was 101.22 kg. The volume of the excised stomach calculated by MDCT correlated with the weight loss achieved 3 months postoperatively. However, no correlation was seen between the gastric sleeve volume 3 months postoperatively and weight loss during this period. MDCT is a good method to measure gastric volume before and after LSG. Early post-operative weight loss (3 months) correlates well with the volume of the excised stomach but not with that of the gastric sleeve.

  16. Dyslexia and Voxel-Based Morphometry: Correlations between Five Behavioural Measures of Dyslexia and Gray and White Matter Volumes

    ERIC Educational Resources Information Center

    Tamboer, Peter; Scholte, H. Steven; Vorst, Harrie C. M.

    2015-01-01

    In voxel-based morphometry studies of dyslexia, the relation between causal theories of dyslexia and gray matter (GM) and white matter (WM) volume alterations is still under debate. Some alterations are consistently reported, but others failed to reach significance. We investigated GM alterations in a large sample of Dutch students (37 dyslexics…

  17. Dyslexia and Voxel-Based Morphometry: Correlations between Five Behavioural Measures of Dyslexia and Gray and White Matter Volumes

    ERIC Educational Resources Information Center

    Tamboer, Peter; Scholte, H. Steven; Vorst, Harrie C. M.

    2015-01-01

    In voxel-based morphometry studies of dyslexia, the relation between causal theories of dyslexia and gray matter (GM) and white matter (WM) volume alterations is still under debate. Some alterations are consistently reported, but others failed to reach significance. We investigated GM alterations in a large sample of Dutch students (37 dyslexics…

  18. Changes in Hippocampal Volume are Correlated with Cell Loss but Not with Seizure Frequency in Two Chronic Models of Temporal Lobe Epilepsy.

    PubMed

    Polli, Roberson S; Malheiros, Jackeline M; Dos Santos, Renan; Hamani, Clement; Longo, Beatriz M; Tannús, Alberto; Mello, Luiz E; Covolan, Luciene

    2014-01-01

    Kainic acid (KA) or pilocarpine (PILO) have been used in rats to model human temporal lobe epilepsy (TLE) but the distribution and severity of structural lesions between these two models may differ. Magnetic resonance imaging (MRI) studies have used quantitative measurements of hippocampal T2 (T2HP) relaxation time and volume, but simultaneous comparative results have not been reported yet. The aim of this study was to compare the MRI T2HP and volume with histological data and frequency of seizures in both models. KA- and PILO-treated rats were imaged with a 2 T MRI scanner. T2HP and volume values were correlated with the number of cells, mossy fiber sprouting, and spontaneous recurrent seizures (SRS) frequency over the 9 months following status epilepticus (SE). Compared to controls, KA-treated rats had unaltered T2HP, pronounced reduction in hippocampal volume and concomitant cell reduction in granule cell layer, CA1 and CA3 at 3 months post SE. In contrast, hippocampal volume was unchanged in PILO-treated animals despite detectable increased T2HP and cell loss in granule cell layer, CA1 and CA3. In the following 6 months, MRI hippocampal volume remained stable with increase of T2HP signal in the KA-treated group. The number of CA1 and CA3 cells was smaller than age-matched CTL group. In contrast, PILO group had MRI volumetric reduction accompanied by reduction in the number of CA1 and CA3 cells. In this group, T2HP signal was unaltered at 6 or 9 months after status. Reductions in the number of cells were not progressive in both models. Notably, the SRS frequency was higher in PILO than in the KA model. The volumetry data correlated well with tissue damage in the epileptic brain, suggesting that MRI may be useful for tracking longitudinal hippocampal changes, allowing the assessment of individual variability and disease progression. Our results indicate that the temporal changes in hippocampal morphology are distinct for both models of TLE and that

  19. Changes in Hippocampal Volume are Correlated with Cell Loss but Not with Seizure Frequency in Two Chronic Models of Temporal Lobe Epilepsy

    PubMed Central

    Polli, Roberson S.; Malheiros, Jackeline M.; dos Santos, Renan; Hamani, Clement; Longo, Beatriz M.; Tannús, Alberto; Mello, Luiz E.; Covolan, Luciene

    2014-01-01

    Kainic acid (KA) or pilocarpine (PILO) have been used in rats to model human temporal lobe epilepsy (TLE) but the distribution and severity of structural lesions between these two models may differ. Magnetic resonance imaging (MRI) studies have used quantitative measurements of hippocampal T2 (T2HP) relaxation time and volume, but simultaneous comparative results have not been reported yet. The aim of this study was to compare the MRI T2HP and volume with histological data and frequency of seizures in both models. KA- and PILO-treated rats were imaged with a 2 T MRI scanner. T2HP and volume values were correlated with the number of cells, mossy fiber sprouting, and spontaneous recurrent seizures (SRS) frequency over the 9 months following status epilepticus (SE). Compared to controls, KA-treated rats had unaltered T2HP, pronounced reduction in hippocampal volume and concomitant cell reduction in granule cell layer, CA1 and CA3 at 3 months post SE. In contrast, hippocampal volume was unchanged in PILO-treated animals despite detectable increased T2HP and cell loss in granule cell layer, CA1 and CA3. In the following 6 months, MRI hippocampal volume remained stable with increase of T2HP signal in the KA-treated group. The number of CA1 and CA3 cells was smaller than age-matched CTL group. In contrast, PILO group had MRI volumetric reduction accompanied by reduction in the number of CA1 and CA3 cells. In this group, T2HP signal was unaltered at 6 or 9 months after status. Reductions in the number of cells were not progressive in both models. Notably, the SRS frequency was higher in PILO than in the KA model. The volumetry data correlated well with tissue damage in the epileptic brain, suggesting that MRI may be useful for tracking longitudinal hippocampal changes, allowing the assessment of individual variability and disease progression. Our results indicate that the temporal changes in hippocampal morphology are distinct for both models of TLE and that

  20. Dose-Volume Parameters of the Corpora Cavernosa Do Not Correlate With Erectile Dysfunction After External Beam Radiotherapy for Prostate Cancer: Results From a Dose-Escalation Trial

    SciTech Connect

    Wielen, Gerard J. van der Hoogeman, Mischa S.; Dohle, Gert R.; Putten, Wim L.J. van; Incrocci, Luca

    2008-07-01

    Purpose: To analyze the correlation between dose-volume parameters of the corpora cavernosa and erectile dysfunction (ED) after external beam radiotherapy (EBRT) for prostate cancer. Methods and Materials: Between June 1997 and February 2003, a randomized dose-escalation trial comparing 68 Gy and 78 Gy was conducted. Patients at our institute were asked to participate in an additional part of the trial evaluating sexual function. After exclusion of patients with less than 2 years of follow-up, ED at baseline, or treatment with hormonal therapy, 96 patients were eligible. The proximal corpora cavernosa (crura), the superiormost 1-cm segment of the crura, and the penile bulb were contoured on the planning computed tomography scan and dose-volume parameters were calculated. Results: Two years after EBRT, 35 of the 96 patients had developed ED. No statistically significant correlations between ED 2 years after EBRT and dose-volume parameters of the crura, the superiormost 1-cm segment of the crura, or the penile bulb were found. The few patients using potency aids typically indicated to have ED. Conclusion: No correlation was found between ED after EBRT for prostate cancer and radiation dose to the crura or penile bulb. The present study is the largest study evaluating the correlation between ED and radiation dose to the corpora cavernosa after EBRT for prostate cancer. Until there is clear evidence that sparing the penile bulb or crura will reduce ED after EBRT, we advise to be careful in sparing these structures, especially when this involves reducing treatment margins.

  1. Correlation of choroidal thickness and volume measurements with axial length and age using swept source optical coherence tomography and optical low-coherence reflectometry.

    PubMed

    Michalewski, Janusz; Michalewska, Zofia; Nawrocka, Zofia; Bednarski, Maciej; Nawrocki, Jerzy

    2014-01-01

    To report choroidal thickness and volume in healthy eyes using swept source optical coherence tomography (SS-OCT). A prospective observational study of 122 patients examined with swept source OCT (DRI-OCT, Topcon, Japan). In each eye, we performed 256 horizontal scans, 12 mm in length and centered on the fovea. We calculated choroidal thickness manually with a built-in caliper and automatically using DRI-OCT mapping software. Choroidal volume was also automatically calculated. We measured axial length with optical low-coherence reflectometry (Lenstar LS 900, Haag-Streit, Switzerland). The choroid has focally increased thickness under the fovea. Choroid was thinnest in the outer nasal quadrant. In stepwise regression analysis, age was estimated as the most significant factor correlating with decreased choroidal thickness (F=23.146, P<0.001) followed by axial length (F=4.902, P=0.03). Refractive error was not statistically significant (F=1.16, P=0.28). SS-OCT is the first commercially available system that can automatically create choroidal thickness and volume maps. Choroidal thickness is increased at the fovea and is thinnest nasally. Age and axial length are critical for the estimation of choroidal thickness and volume. Choroidal measurements derived from SS-OCT images have potential value for objectively documenting disease-related choroidal thickness abnormalities and monitoring progressive changes over time.

  2. Apoptotic markers in cultured fibroblasts correlate with brain metabolites and regional brain volume in antipsychotic-naive first-episode schizophrenia and healthy controls

    PubMed Central

    Batalla, A; Bargalló, N; Gassó, P; Molina, O; Pareto, D; Mas, S; Roca, J M; Bernardo, M; Lafuente, A; Parellada, E

    2015-01-01

    Cultured fibroblasts from first-episode schizophrenia patients (FES) have shown increased susceptibility to apoptosis, which may be related to glutamate dysfunction and progressive neuroanatomical changes. Here we determine whether apoptotic markers obtained from cultured fibroblasts in FES and controls correlate with changes in brain glutamate and N-acetylaspartate (NAA) and regional brain volumes. Eleven antipsychotic-naive FES and seven age- and gender-matched controls underwent 3-Tesla magnetic resonance imaging scanning. Glutamate plus glutamine (Glx) and NAA levels were measured in the anterior cingulate (AC) and the left thalamus (LT). Hallmarks of apoptotic susceptibility (caspase-3-baseline activity, phosphatidylserine externalization and chromatin condensation) were measured in fibroblast cultures obtained from skin biopsies after inducing apoptosis with staurosporine (STS) at doses of 0.25 and 0.5 μM. Apoptotic biomarkers were correlated to brain metabolites and regional brain volume. FES and controls showed a negative correlation in the AC between Glx levels and percentages of cells with condensed chromatin (CC) after both apoptosis inductions (STS 0.5 μM: r=−0.90; P=0.001; STS 0.25 μM: r=−0.73; P=0.003), and between NAA and cells with CC (STS 0.5 μM induction r=−0.76; P=0.002; STS 0.25 μM r=−0.62; P=0.01). In addition, we found a negative correlation between percentages of cells with CC and regional brain volume in the right supratemporal cortex and post-central region (STS 0.25 and 0.5 μM; P<0.05 family-wise error corrected (FWEc)). We reveal for the first time that peripheral markers of apoptotic susceptibility may correlate with brain metabolites, Glx and NAA, and regional brain volume in FES and controls, which is consistent with the neuroprogressive theories around the onset of the schizophrenia illness. PMID:26305477

  3. Parametric study of CHF data. Volume 2. A generalized subchannel CHF correlation for PWR and BWR fuel assemblies. Final report

    SciTech Connect

    Reddy, D.G.; Fighetti, C.F.

    1983-01-01

    The primary objective of this research was to develop a generalized subchannel CHF correlation based on the local fluid conditions obtained with the COBRA-IIIC thermal hydraulic subchannel code and covering PWR and BWR normal operating conditions as well as hypothetical loss-of-coolant accident (LOCA) conditions. In view of the importance of the local conditions predicted by the COBRA-IIIC code in the development of CHR correlation, the secondary objective was to improve the predictive capability of the COBRA-IIIC subchannel code. In the first phase of this study, the sensitivity of local enthalpies and local mass fluxes predicted by the COBRA-IIIC subchannel code to subcooled void correlation, bulk void correlation, two-phase friction multiplier correlation and turbulent mixing parameter was determined. In the second phase, based on the local conditions obtained with the COBRA-IIIC subchannel code, an accurate generalized subchannel CHF correlation was developed utilizing 3607 CHF data points from 65 test sections simulating PWR and BWR fuel assemblies.

  4. Neural Correlates of Biased Responses: The Negative Method Effect in the Rosenberg Self-Esteem Scale Is Associated with Right Amygdala Volume.

    PubMed

    Wang, Yinan; Kong, Feng; Huang, Lijie; Liu, Jia

    2016-10-01

    Self-esteem is a widely studied construct in psychology that is typically measured by the Rosenberg Self-Esteem Scale (RSES). However, a series of cross-sectional and longitudinal studies have suggested that a simple and widely used unidimensional factor model does not provide an adequate explanation of RSES responses due to method effects. To identify the neural correlates of the method effect, we sought to determine whether and how method effects were associated with the RSES and investigate the neural basis of these effects. Two hundred and eighty Chinese college students (130 males; mean age = 22.64 years) completed the RSES and underwent magnetic resonance imaging (MRI). Behaviorally, method effects were linked to both positively and negatively worded items in the RSES. Neurally, the right amygdala volume negatively correlated with the negative method factor, while the hippocampal volume positively correlated with the general self-esteem factor in the RSES. The neural dissociation between the general self-esteem factor and negative method factor suggests that there are different neural mechanisms underlying them. The amygdala is involved in modulating negative affectivity; therefore, the current study sheds light on the nature of method effects that are related to self-report with a mix of positively and negatively worded items. © 2015 Wiley Periodicals, Inc.

  5. Three-dimensional placental volume and mean grey value: Normal ranges in a Turkish population and correlation with maternal serum biochemistry and Doppler parameters.

    PubMed

    Pala, H G; Artunc Ulkumen, B; Uyar, Y; Koyuncu, F M; Bulbul Baytur, Y

    2015-04-01

    The aim of this study is to evaluate the relationship between three-dimensional (3D) ultrasound measurements of placenta at 11-13(6) weeks' gestation and maternal serum levels of pregnancy associated plasma protein-A (PAPP-A), free beta human chorionic gonadotrophin (fβhCG), Doppler parameters in early pregnancy. This prospective study consisted of 334 singleton pregnancies at 11-13(6) weeks' gestation. Placental volume and placental volumetric mean grey values were evaluated. The placental volume (cm(3)) was analysed using the Virtual Organ Computer-aided AnaLysis (VOCAL) imaging program and 3D histogram was used to calculate the volumetric mean grey value (%). Mean maternal age was 28.35 ± 7.55. Mean gestational age was 12.29 ± 0.68 weeks. Placental volume was 77.04 ± 35.74 cm(3). Mean grey value of the placenta was 34.38 ± 8.02%. Correlation analysis revealed that placental volume was significantly correlated with the crown-rump length (r = 0.173, p = 0.002), gestational week (r = 0.116, p = 0.036), ductus venosus pulsatility index (r = -0.101, p = 0.04) and maternal weight (r = 0.099, p = 0.037). There was a significant relation between the mean grey value of the placenta and maternal age (r = 0.131, p = 0.02), nuchal translucency (r = -0.109, p = 0.048), PAPP-A (r = 0.108, p = 0.04) and fβhCG (r = 0.104, p = 0.042). Volumetry of the placenta can be carried out with a high percentage of 1st trimester pregnancies. Volumetry during the 1st trimester could be helpful because of the less advanced state of placentation. This examination is easy to perform and the measurements can be acquired correctly and quickly.

  6. The evaluation of carotid intima-media thickness and mean platelet volume values and correlation with cardiac functions in obese children.

    PubMed

    Özkan, Esra Akyüz; Khosroshahi, Hashem E; Serin, Halil İbrahim; Özdemir, Zeynep Tuba; Kılıç, Mahmut; Ekim, Meral; Geçit, U Aliye; Domur, Esra

    2015-01-01

    Obesity is associated with many risk factors, such as hyperlipidemia, hyperinsulinemia, hypertension and leads to early atherosclerosis. The aim of this study was to investigate the relation of the mean platelet volume (MPV) and the carotid intima media thickness (CIMT) on cardiac functions among obese children. Sixty obese children, with body mass index percentile were >95% and forty eight healthy controls were enrolled in the study. Triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), thyroid function tests, hemoglobin, white blood cell, MPV and insulin resistance were evaluated. CIMT was measured by using high-resolution ultrasound and echocardiography was performed to all individuals. MPV and CIMT values were found significantly higher in obese children than controls. There was positive correlation between CIMT and age, body surface area (BSA), systolic and diastolic blood pressure, left ventricular meridional end-systolic wall stress (ESWSm), myocardial fiber stress (MFS), stroke volume (SV) and insulin and negative correlation with left ventricle end-systolic elastance by single beat technique (Ees(sb)) and arterial elastance (Ea). There was no correlation between LVM, cardiac risk profiles and CIMT. Multiple stepwise regression analyses revealed that ESWSm (β=0.337, P=0.049) was only independent factor on CIMT. MPV values showed negative correlation with ALT, AST, Free T4, thyroid stimulating hormone and positive correlation with age and BSA. Current study showed that obesity has an independent impact on CIMT and MPV values in children. Increased CIMT in obese children leads significant increase in ESWSm and decrease in Ea and Ees(sb).

  7. Novel computational approach for studying ph effects, excluded volume and ion-ion correlations in electrical double layers around polyelectrolytes and nanoparticles

    NASA Astrophysics Data System (ADS)

    Ovanesyan, Zaven

    Highly charged cylindrical and spherical objects (macroions) are probably the simplest structures for modeling nucleic acids, proteins and nanoparticles. Their ubiquitous presence within biophysical systems ensures that Coulomb forces are among the most important interactions that regulate the behavior of these systems. In these systems, ions position themselves in a strongly correlated manner near the surface of a macroion and form electrical double layers (EDLs). These EDLs play an important role in many biophysical and biochemical processes. For instance, the macroion's net charge can change due to the binding of many multivalent ions to its surface. Thus, proper description of EDLs near the surface of a macroion may reveal a counter-intuitive charge inversion behavior, which can generate attraction between like-charged objects. This is relevant for the variety of fields such as self-assembly of DNA and RNA folding, as well as for protein aggregation and neurodegenerative diseases. Certainly, the key factors that contribute to these phenomena cannot be properly understood without an accurate solvation model. With recent advancements in computer technologies, the possibility to use computational tools for fundamental understanding of the role of EDLs around biomolecules and nanoparticles on their physical and chemical properties is becoming more feasible. Establishing the impact of the excluded volume and ion-ion correlations, ionic strength and pH of the electrolyte on the EDL around biomolecules and nanoparticles, and how changes in these properties consequently affect the Zeta potential and surface charge density are still not well understood. Thus, modeling and understanding the role of these properties on EDLs will provide more insights on the stability, adsorption, binding and function of biomolecules and nanoparticles. Existing mean-field theories such as Poisson Boltzmann (PB) often neglect the ion-ion correlations, solvent and ion excluded volume effects

  8. Strain uncertainties from two digital volume correlation approaches in prophylactically augmented vertebrae: Local analysis on bone and cement-bone microstructures.

    PubMed

    Tozzi, Gianluca; Dall'Ara, Enrico; Palanca, Marco; Curto, Marco; Innocente, Federica; Cristofolini, Luca

    2017-03-01

    Combination of micro-focus computed tomography (micro-CT) in conjunction with in situ mechanical testing and digital volume correlation (DVC) can be used to access the internal deformation of materials and structures. DVC has been exploited over the past decade to measure complex deformation fields within biological tissues and bone-biomaterial systems. However, before adopting it in a clinically-relevant context (i.e. bone augmentation in vertebroplasty), the research community should focus on understanding the reliability of such method in different orthopaedic applications involving the use of biomaterials. The aim of this study was to evaluate systematic and random errors affecting the strain computed with two different DVC approaches (a global one, "ShIRT-FE", and a local one, "DaVis-DC") in different microstructures within augmented vertebrae, such as trabecular bone, cortical bone and cement-bone interdigitation. The results showed that systematic error was insensitive to the size of the computation sub-volume used for the DVC correlation. Conversely, the random error (which was generally the largest component of error) was lower for a 48-voxel (1872micrometer) sub-volume (64-221 microstrain for ShIRT-FE, 88-274 microstrain for DaVis-DC), than for a 16-voxel (624micrometer) sub-volume (359-1203 microstrain for ShIRT-FE, 960-1771 microstrain for DaVis-DC) for the trabecular and cement regions. Overall, the local random error did not appear to be influenced by either bone microarchitecture or presence of biomaterial. For the 48-voxel sub-volume the global approach was less sensitive to the gradients in grey-values at the cortical surface (random error below 200 microstrain), while the local approach showed errors up to 770 microstrain. Mean absolute error (MAER) and standard deviation of error (SDER) were also calculated and substantially improved when compared to recent literature for the cement-bone interface. The multipass approach for DaVis-DC further

  9. Structure-function relationships in the stem cell's mechanical world B: emergent anisotropy of the cytoskeleton correlates to volume and shape changing stress exposure.

    PubMed

    Chang, Hana; Knothe Tate, Melissa L

    2011-12-01

    attributable to magnitude of the stress to which the cell is exposed globally (0.5 versus 1.0 dyne/cm2). Furthermore, changes in the actin cytoskeletal distribution correlate positively with one pre-mesenchymal condensation marker (Msx2) and negatively with early markers of chondrogenesis (ColIIaI alone, indicative of pre-hypertrophic chondrogenesis) and osteogenesis (Runx2). Changes in the tubulin cytoskeletal distribution correlate positively with a marker of pericondensation (Sox9 alone), negatively with chondrogenesis (ColIIaI) and positively with adipogenesis (Ppar-gamma 2). Taken as a whole, exposure of MSCs to volume and shape changing stresses results in emergent anisotropy of cytoskeletal architecture (structure), which relate to emergent cell fate (function).

  10. Character process model for semen volume in AI rams: evaluation of correlation structures for long and short-term environmental effects

    PubMed Central

    David, Ingrid; Bodin, Loys; Lagriffoul, Gilles; Manfredi, Eduardo; Robert-Granié, Christèle

    2007-01-01

    The objective of this study was to build a character process model taking into account serial correlations for the analysis of repeated measurements of semen volume in AI rams. For each ram, measurements were repeated within and across years. Therefore, we considered a model including three environmental effects: the long-term environmental effect, which is a random year* subject effect, the short-term environmental effect, which is a random within year subject* collection effect, and the classical measurement error. We used a four-step approach to build the model. The first step explored graphically the serial correlations. The second step compared four models with different correlation structures for the short-term environmental effect. We selected fixed effects in the third step. In the fourth step, we compared four correlation structures for the long-term environmental effect. The model, which fitted best the data, used a spatial power correlation structure for the short-term environmental effect and a first order autoregressive process for the long-term environmental effect. The heritability estimate was 0.27 (0.04), the within year repeatability decreased from 0.56 to 0.44 and the repeatability across years decreased from 0.43 to 0.37. PMID:17212948

  11. Correlation of physical properties with molecular structure for some dicyclic hydrocarbons having high thermal-energy release per unit volume

    NASA Technical Reports Server (NTRS)

    Wise, P H; Serijan, K T; Goodman, I A

    1951-01-01

    As part of a program to study the correlation between molecular structure and physical properties of high-density hydrocarbons, the net heats of combustion, melting points, boiling points, densities, and kinematic viscosities of some hydrocarbons in the 2-n-alkylbiphenyl, 1,1-diphenylalkane, diphenylalkane, 1,1-dicyclohexylalkane, and dicyclohexylalkane series are presented.

  12. PACER -- A fast running computer code for the calculation of short-term containment/confinement loads following coolant boundary failure. Volume 1: Code models and correlations

    SciTech Connect

    Sienicki, J.J.

    1997-06-01

    A fast running and simple computer code has been developed to calculate pressure loadings inside light water reactor containments/confinements under loss-of-coolant accident conditions. PACER was originally developed to calculate containment/confinement pressure and temperature time histories for loss-of-coolant accidents in Soviet-designed VVER reactors and is relevant to the activities of the US International Nuclear Safety Center. The code employs a multicompartment representation of the containment volume and is focused upon application to early time containment phenomena during and immediately following blowdown. Flashing from coolant release, condensation heat transfer, intercompartment transport, and engineered safety features are described using best estimate models and correlations often based upon experiment analyses. Two notable capabilities of PACER that differ from most other containment loads codes are the modeling of the rates of steam and water formation accompanying coolant release as well as the correlations for steam condensation upon structure.

  13. Volume fluctuation and auto-correlation effects in the moment analysis of net-proton multiplicity distributions in heavy-ion collisions

    NASA Astrophysics Data System (ADS)

    Luo, Xiaofeng; Xu, Ji; Mohanty, Bedangadas; Xu, Nu

    2013-10-01

    Moments (variance (σ2), skewness (S), kurtosis (κ)) of multiplicity distributions of conserved quantities, such as net-baryon, net-charge and net-strangeness, are predicted to be sensitive to the correlation length of the system and connected to the thermodynamic susceptibilities computed in the Lattice QCD and Hadron Resonance Gas model. In this paper, we present several measurement artifacts that could lead to volume fluctuation and auto-correlation effects in the moment analysis of net-proton multiplicity distributions in heavy-ion collisions using the ultra-relativistic quantum molecular dynamics model. We discuss methods to overcome these artifacts so that the extracted moments can be used to obtain physical conclusions. In addition, we present methods to properly estimate the statistical errors in moment analysis.

  14. Sexual dimorphism in the human face assessed by euclidean distance matrix analysis.

    PubMed Central

    Ferrario, V F; Sforza, C; Pizzini, G; Vogel, G; Miani, A

    1993-01-01

    The form of any object can be viewed as a combination of size and shape. A recently proposed method (euclidean distance matrix analysis) can differentiate between size and shape differences. It has been applied to analyse the sexual dimorphism in facial form in a sample of 108 healthy young adults (57 men, 51 women). The face was wider and longer in men than in women. A global shape difference was demonstrated, the male face being more rectangular and the female face more square. Gender variations involved especially the lower third of the face and, in particular, the position of the pogonion relative to the other structures. PMID:8300436

  15. Embedding compact surfaces into the 3-dimensional Euclidean space with maximum symmetry

    NASA Astrophysics Data System (ADS)

    Wang, Chao; Wang, ShiCheng; Zhang, YiMu; Zimmermann, Bruno

    2017-09-01

    The symmetries of surfaces which can be embedded into the symmetries of the 3-dimensional Euclidean space $\\mathbb{R}^3$ are easier to feel by human's intuition. We give the maximum order of finite group actions on $(\\mathbb{R}^3, \\Sigma)$ among all possible embedded closed/bordered surfaces with given geometric/algebraic genus $>1$ in $\\mathbb{R}^3$. We also identify the topological types of the bordered surfaces realizing the maximum order, and find simple representative embeddings for such surfaces.

  16. Relation between Darboux and type-2 Bishop frames in Euclidean space

    NASA Astrophysics Data System (ADS)

    Yilmaz, Amine; Özyilmaz, Emin

    2016-06-01

    In this work, we investigate relationships between Darboux and type-2 Bishop frames in Euclidean space. Then, we obtain the geodesic curvature of the spherical image curve of the Darboux vector of the type-2 Bishop frame. Also, we give transition matrix between the Darboux and type-2 Bishop frames of the type-2 Bishop frames of the spherical images of the edges N→1,N→2 and b→. Finally, we express some interesting relations and illustrate of the examples by the aid Maple programe.

  17. Convex hull and tour crossings in the Euclidean traveling salesperson problem: implications for human performance studies.

    PubMed

    Van Rooij, Iris; Stege, Ulrike; Schactman, Alissa

    2003-03-01

    Recently there has been growing interest among psychologists in human performance on the Euclidean traveling salesperson problem (E-TSP). A debate has been initiated on what strategy people use in solving visually presented E-TSP instances. The most prominent hypothesis is the convex-hull hypothesis, originally proposed by MacGregor and Ormerod (1996). We argue that, in the literature so far, there is no evidence for this hypothesis. Alternatively we propose and motivate the hypothesis that people aim at avoiding crossings.

  18. Brain Tissue Volumes and Perfusion Change with the Number of Optic Neuritis Attacks in Relapsing Neuromyelitis Optica: A Voxel-Based Correlation Study.

    PubMed

    Sánchez-Catasús, Carlos A; Cabrera-Gomez, José; Almaguer Melián, William; Giroud Benítez, José Luis; Rodríguez Rojas, Rafael; Bayard, Jorge Bosch; Galán, Lídice; Sánchez, Reinaldo Galvizu; Fuentes, Nancy Pavón; Valdes-Sosa, Pedro

    2013-01-01

    Recent neuroimaging studies show that brain abnormalities in neuromyelitis optica (NMO) are more frequent than earlier described. Yet, more research considering multiple aspects of NMO is necessary to better understand these abnormalities. A clinical feature of relapsing NMO (RNMO) is that the incremental disability is attack-related. Therefore, association between the attack-related process and neuroimaging might be expected. On the other hand, the immunopathological analysis of NMO lesions has suggested that CNS microvasculature could be an early disease target, which could alter brain perfusion. Brain tissue volume changes accompanying perfusion alteration could also be expected throughout the attack-related process. The aim of this study was to investigate in RNMO patients, by voxel-based correlation analysis, the assumed associations between regional brain white (WMV) and grey matter volumes (GMV) and/or perfusion on one side, and the number of optic neuritis (ON) attacks, myelitis attacks and/or total attacks on the other side. For this purpose, high resolution T1-weighted MRI and perfusion SPECT imaging were obtained in 15 RNMO patients. The results showed negative regional correlations of WMV, GMV and perfusion with the number of ON attacks, involving important components of the visual system, which could be relevant for the comprehension of incremental visual disability in RNMO. We also found positive regional correlation of perfusion with the number of ON attacks, mostly overlapping the brain area where the WMV showed negative correlation. This provides evidence that brain microvasculature is an early disease target and suggests that perfusion alteration could be important in the development of brain structural abnormalities in RNMO.

  19. Data correlation and analysis of arc tunnel and wind tunnel tests of RSI joints and gaps. Volume 1: Technical report

    NASA Technical Reports Server (NTRS)

    Christensen, H. E.; Kipp, H. W.

    1974-01-01

    Heat transfer data measured in gaps typical of those under consideration for joints in space shuttle reusable surface insulation protection systems have been assimilated, analyzed and correlated. The data were obtained in four NASA facilities. Several types of gaps were investigated with emphasis on simple butt joints. Gap widths ranged from 0.07 to 0.7 cm and depths ranged from 1 to 6 cm. Laminar, transitional and turbulent boundary layer flows over the gap opening were investigated. Three-dimensional heating variations were observed within gaps in the absence of external flow pressure gradients. Heat transfer correlation equations were obtained for several of the tests. Thermal protection system performance with and without gaps was compared for a representative shuttle entry trajectory.

  20. Spherical roller bearing analysis. SKF computer program SPHERBEAN. Volume 3: Program correlation with full scale hardware tests

    NASA Technical Reports Server (NTRS)

    Kleckner, R. J.; Rosenlieb, J. W.; Dyba, G.

    1980-01-01

    The results of a series of full scale hardware tests comparing predictions of the SPHERBEAN computer program with measured data are presented. The SPHERBEAN program predicts the thermomechanical performance characteristics of high speed lubricated double row spherical roller bearings. The degree of correlation between performance predicted by SPHERBEAN and measured data is demonstrated. Experimental and calculated performance data is compared over a range in speed up to 19,400 rpm (0.8 MDN) under pure radial, pure axial, and combined loads.

  1. Data correlation and analysis of arc tunnel and wind tunnel tests of RSI joints and gaps. Volume 2: Data base

    NASA Technical Reports Server (NTRS)

    Christensen, H. E.; Kipp, H. W.

    1974-01-01

    Wind tunnel tests were conducted to determine the aerodynamic heating created by gaps in the reusable surface insulation (RSI) thermal protection system (TPS) for the space shuttle. The effects of various parameters of the RSI on convective heating characteristics are described. The wind tunnel tests provided a data base for accurate assessment of gap heating. Analysis and correlation of the data provide methods for predicting heating in the RSI gaps on the space shuttle.

  2. Correlation of Stroke Volume Measurement between Sonosite Portable Echocardiogram and Edwards Flotrac Sensor-Vigileo Monitor in an Intensive Care Unit

    PubMed Central

    Behnia, Mehrdad; Powell, Sherry; Fallen, Linda; Tamaddon, Houman; Behnia, Masud

    2013-01-01

    Purpose Stroke volume (SV) is a parameter that is being recognized as an endpoint in fluid resuscitation algorithms. Its role is now being realized as an important variable in hemodynamic assessment in various clinical scenarios such as septic and cardiogenic shocks. Direct measurement of stroke volume (SV) and its novel corollary, stroke volume variation (SVV) derived by proprietary software, are preferred over mean cardiac output (CO) measurements because they render a more accurate reflection of hemodynamic status independent of heart rate. Flotrac-Vigileo monitor (FTV) (Edwards Lifesciences, Irvine, CA, USA) is a system that uses a complex algorithm analyzing arterial waveform to calculate SV, SVV, and CO. We assessed the feasibility of obtaining SV measurements with a portable echocardiogram and validated its accuracy with the FTV system in mechanically ventilated patients in our intensive care unit (ICU). Furthermore, we emphasized the importance of hemodynamic measurements and familiarity with critical care echocardiography for the intensivists. Methods Ten patients who were on mechanical ventilation were studied. A femoral arterial line was connected to the FTV system monitoring SV and CO. A portable echocardiogram (M-Turbo; Sonosite, Bothell, WA) was used to measure SV. CO was calculated by multiplying SV by heart rate. No patient had arrhythmia. We used biplane Simpson’s method of discs to calculate SV in which subtraction of end-systolic volume from end-diastolic volume yields the SV. Results The comparison of simultaneous SV and CO measurements by echocardiography with FTV showed a strong correlation between the 2. (For SV, y = 0.9545x + 3.3, R2 = 0.98 and for CO, y = 0.9104x + 7.7074, R2 = 0.97). Conclusions In our small cohort, the SV and CO measured by a portable echocardiogram (Sonosite M-Turbo) appears to be closely correlated with their respective values measured by FTV. Portable echocardiography is a reliable noninvasive tool for the

  3. Automated CT Perfusion Ischemic Core Volume and Noncontrast CT ASPECTS (Alberta Stroke Program Early CT Score): Correlation and Clinical Outcome Prediction in Large Vessel Stroke.

    PubMed

    Haussen, Diogo C; Dehkharghani, Seena; Rangaraju, Srikant; Rebello, Leticia C; Bouslama, Mehdi; Grossberg, Jonathan A; Anderson, Aaron; Belagaje, Samir; Frankel, Michael; Nogueira, Raul G

    2016-09-01

    The semiquantitative noncontrast CT Alberta Stroke Program Early CT Score (ASPECTS) and RAPID automated computed tomography (CT) perfusion (CTP) ischemic core volumetric measurements have been used to quantify infarct extent. We aim to determine the correlation between ASPECTS and CTP ischemic core, evaluate the variability of core volumes within ASPECTS strata, and assess the strength of their association with clinical outcomes. Review of a prospective, single-center database of consecutive thrombectomies of middle cerebral or intracranial internal carotid artery occlusions with pretreatment CTP between September 2010 and September 2015. CTP was processed with RAPID software to identify ischemic core (relative cerebral blood flow<30% of normal tissue). Three hundred and thirty-two patients fulfilled inclusion criteria. Median age was 66 years (55-75), median ASPECTS was 8 (7-9), whereas median CTP ischemic core was 11 cc (2-27). Median time from last normal to groin puncture was 5.8 hours (3.9-8.8), and 90-day modified Rankin scale score 0 to 2 was observed in 54%. The correlation between CTP ischemic core and ASPECTS was fair (R=-0.36; P<0.01). Twenty-six patients (8%) had ASPECTS <6 and CTP core ≤50 cc (37% had modified Rankin scale score 0-2, whereas 29% were deceased at 90 days). Conversely, 27 patients (8%) had CTP core >50 cc and ASPECTS ≥6 (29% had modified Rankin scale 0-2, whereas 21% were deceased at 90 days). Moderate correlations between ASPECTS and final infarct volume (R=-0.42; P<0.01) and between CTP ischemic core and final infarct volume (R=0.50; P<0.01) were observed; coefficients were not significantly influenced by the time from stroke onset to presentation. Multivariable regression indicated ASPECTS ≥6 (odds ratio 4.10; 95% confidence interval, 1.47-11.46; P=0.01) and CTP core ≤50 cc (odds ratio 3.86; 95% confidence interval, 1.22-12.15; P=0.02) independently and comparably predictive of good outcome. There is wide variability of CTP

  4. 3D micro-scale deformations of wood in bending: synchrotron radiation muCT data analyzed with digital volume correlation.

    PubMed

    Forsberg, F; Mooser, R; Arnold, M; Hack, E; Wyss, P

    2008-12-01

    A micro-scale three-point-bending experiment with a wood specimen was carried out and monitored by synchrotron radiation micro-computed tomography. The full three-dimensional wood structure of the 1.57x3.42x0.75mm(3) specimen was reconstructed at cellular level in different loading states. Furthermore, the full three-dimensional deformation field of the loaded wood specimen was determined by digital volume correlation, applied to the reconstructed data at successive loading states. Results from two selected regions within the wood specimen are presented as continuous displacement and strain fields in both 2D and 3D. The applied combination of synchrotron radiation micro-computed tomography and digital volume correlation for the deformation analysis of wood under bending stress is a novel application in wood material science. The method offers the potential for the simultaneous observation of structural changes and quantified deformations during in situ micro-mechanical experiments. Moreover, the high spatial resolution allows studying the influence of anatomical features on the fracture behaviour of wood. Possible applications of this method range from bio-mechanical observations in fresh plant tissue to fracture mechanics aspects in structural timber.

  5. Subregional Structural Alterations in Hippocampus and Nucleus Accumbens Correlate with the Clinical Impairment in Patients with Alzheimer's Disease Clinical Spectrum: Parallel Combining Volume and Vertex-Based Approach.

    PubMed

    Nie, Xiuling; Sun, Yu; Wan, Suiren; Zhao, Hui; Liu, Renyuan; Li, Xueping; Wu, Sichu; Nedelska, Zuzana; Hort, Jakub; Qing, Zhao; Xu, Yun; Zhang, Bing

    2017-01-01

    Deep gray matter structures are associated with memory and other important functions that are impaired in Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, systematic characterization of the subregional atrophy and deformations in these structures in AD and MCI still need more investigations. In this article, we combined complex volumetry- and vertex-based analysis to investigate the pattern of subregional structural alterations in deep gray matter structures and its association with global clinical scores in AD (n = 30) and MCI patients (n = 30), compared to normal controls (NCs, n = 30). Among all seven pairs of structures, the bilateral hippocampi and nucleus accumbens showed significant atrophy in AD compared with NCs (p < 0.05). But only the subregional atrophy in the dorsal-medial part of the left hippocampus, the ventral part of right hippocampus, and the left nucleus accumbens, the posterior part of the right nucleus accumbens correlated with the worse clinical scores of MMSE and MOCA (p < 0.05). Furthermore, the medial-ventral part of right thalamus significantly shrank and correlated with clinical scores without decreasing in its whole volume (p > 0.05). In conclusion, the atrophy of these four subregions in bilateral hippocampi and nucleus accumbens was associated with cognitive impairment of patients, which might be potential target regions of treatment in AD. The surface analysis could provide additional information to volume comparison in finding the early pathological progress in deep gray matter structures.

  6. Correlation of (18)F-FDG avid volumes on pre-radiation therapy and post-radiation therapy FDG PET scans in recurrent lung cancer.

    PubMed

    Shusharina, Nadya; Cho, Joseph; Sharp, Gregory C; Choi, Noah C

    2014-05-01

    To investigate the spatial correlation between high uptake regions of 2-deoxy-2-[(18)F]-fluoro-D-glucose positron emission tomography ((18)F-FDG PET) before and after therapy in recurrent lung cancer. We enrolled 106 patients with inoperable lung cancer into a prospective study whose primary objectives were to determine first, the earliest time point when the maximum decrease in FDG uptake representing the maximum metabolic response (MMR) is attainable and second, the optimum cutoff value of MMR based on its predicted tumor control probability, sensitivity, and specificity. Of those patients, 61 completed the required 4 serial (18)F-FDG PET examinations after therapy. Nineteen of 61 patients experienced local recurrence at the primary tumor and underwent analysis. The volumes of interest (VOI) on pretherapy FDG-PET were defined by use of an isocontour at ≥50% of maximum standard uptake value (SUVmax) (≥50% of SUVmax) with correction for heterogeneity. The VOI on posttherapy images were defined at ≥80% of SUVmax. The VOI of pretherapy and posttherapy (18)F-FDG PET images were correlated for the extent of overlap. The size of VOI at pretherapy images was on average 25.7% (range, 8.8%-56.3%) of the pretherapy primary gross tumor volume (GTV), and their overlap fractions were 0.8 (95% confidence interval [CI]: 0.7-0.9), 0.63 (95% CI: 0.49-0.77), and 0.38 (95% CI: 0.19-0.57) of VOI of posttherapy FDG PET images at 10 days, 3 months, and 6 months, respectively. The residual uptake originated from the pretherapy VOI in 15 of 17 cases. VOI defined by the SUVmax-≥50% isocontour may be a biological target volume for escalated radiation dose. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Correlation of 18F-FDG Avid Volumes on Pre–Radiation Therapy and Post–Radiation Therapy FDG PET Scans in Recurrent Lung Cancer

    PubMed Central

    Shusharina, Nadya; Cho, Joseph; Sharp, Gregory C.; Choi, Noah C.

    2014-01-01

    Purpose To investigate the spatial correlation between high uptake regions of 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography (18F-FDG PET) before and after therapy in recurrent lung cancer. Methods and Materials We enrolled 106 patients with inoperable lung cancer into a prospective study whose primary objectives were to determine first, the earliest time point when the maximum decrease in FDG uptake representing the maximum metabolic response (MMR) is attainable and second, the optimum cutoff value of MMR based on its predicted tumor control probability, sensitivity, and specificity. Of those patients, 61 completed the required 4 serial 18F-FDG PET examinations after therapy. Nineteen of 61 patients experienced local recurrence at the primary tumor and underwent analysis. The volumes of interest (VOI) on pretherapy FDG-PET were defined by use of an isocontour at ≥50% of maximum standard uptake value (SUVmax) (≥50% of SUVmax) with correction for heterogeneity. The VOI on posttherapy images were defined at ≥80% of SUVmax. The VOI of pretherapy and posttherapy 18F-FDG PET images were correlated for the extent of overlap. Results The size of VOI at pretherapy images was on average 25.7% (range, 8.8%-56.3%) of the pretherapy primary gross tumor volume (GTV), and their overlap fractions were 0.8 (95% confidence interval [CI]: 0.7-0.9), 0.63 (95% CI: 0.49-0.77), and 0.38 (95% CI: 0.19-0.57) of VOI of posttherapy FDG PET images at 10 days, 3 months, and 6 months, respectively. The residual uptake originated from the pretherapy VOI in 15 of 17 cases. Conclusions VOI defined by the SUVmax- ≥50% isocontour may be a biological target volume for escalated radiation dose. PMID:24725696

  8. Ultrasonographic evaluation of parathyroid hyperplasia in multiple endocrine neoplasia type 1: Positive correlation between parathyroid volume and circulating parathyroid hormone concentration.

    PubMed

    Tamiya, Hiroyuki; Miyakawa, Megumi; Takeshita, Akira; Miura, Daishu; Takeuchi, Yasuhiro

    2015-09-01

    There are few reports on parathyroid ultrasonography of multiple endocrine neoplasia type 1 (MEN1). This study investigated the ultrasonographic features of parathyroid glands in 10 patients with MEN1 who underwent preoperative neck ultrasonography and parathyroidectomy between 2006 and 2010 at Toranomon Hospital. We retrospectively analyzed clinical features, laboratory and ultrasonographic data, and pathological diagnosis. A total of 38 parathyroid glands were surgically removed (three to five glands from each patient). All removed parathyroids were pathologically diagnosed as hyperplasia. Seven cases (70.0 %) had adenomatous thyroid nodules. Twenty-five enlarged parathyroid glands (65.8 %) were detected by preoperative ultrasonography with a detection rate of 81.8 % (9/11) and 59.3 % (16/27) for patients without and with adenomatous nodules, respectively. Total parathyroid gland weight and potentially predictable total parathyroid volume by preoperative ultrasonography were significantly correlated with preoperative serum intact parathyroid hormone (iPTH) concentration (R = 0.97, P < 0.001 and R = 0.96, P < 0.001, respectively). The equation used for prediction of the total volume by ultrasonography was 15 × iPTH (pg/ml) - 1,000 and that for total weight was 20 × iPTH (pg/ml) - 1,400. Although adenomatous nodules often coexisted with MEN1 and made identification of enlarged parathyroid glands by ultrasonography difficult, the positive correlation between the predictable parathyroid volume by ultrasonography and serum iPTH suggests that their measurement is useful in the preoperative detection and localization of enlarged parathyroid glands in patients with MEN1. Furthermore, the presence of parathyroid glands that should be resected can be predicted before surgery using the equation proposed here.

  9. Correlation of {sup 18}F-FDG Avid Volumes on Pre–Radiation Therapy and Post–Radiation Therapy FDG PET Scans in Recurrent Lung Cancer

    SciTech Connect

    Shusharina, Nadya Cho, Joseph; Sharp, Gregory C.; Choi, Noah C.

    2014-05-01

    Purpose: To investigate the spatial correlation between high uptake regions of 2-deoxy-2-[{sup 18}F]-fluoro-D-glucose positron emission tomography ({sup 18}F-FDG PET) before and after therapy in recurrent lung cancer. Methods and Materials: We enrolled 106 patients with inoperable lung cancer into a prospective study whose primary objectives were to determine first, the earliest time point when the maximum decrease in FDG uptake representing the maximum metabolic response (MMR) is attainable and second, the optimum cutoff value of MMR based on its predicted tumor control probability, sensitivity, and specificity. Of those patients, 61 completed the required 4 serial {sup 18}F-FDG PET examinations after therapy. Nineteen of 61 patients experienced local recurrence at the primary tumor and underwent analysis. The volumes of interest (VOI) on pretherapy FDG-PET were defined by use of an isocontour at ≥50% of maximum standard uptake value (SUV{sub max}) (≥50% of SUV{sub max}) with correction for heterogeneity. The VOI on posttherapy images were defined at ≥80% of SUV{sub max}. The VOI of pretherapy and posttherapy {sup 18}F-FDG PET images were correlated for the extent of overlap. Results: The size of VOI at pretherapy images was on average 25.7% (range, 8.8%-56.3%) of the pretherapy primary gross tumor volume (GTV), and their overlap fractions were 0.8 (95% confidence interval [CI]: 0.7-0.9), 0.63 (95% CI: 0.49-0.77), and 0.38 (95% CI: 0.19-0.57) of VOI of posttherapy FDG PET images at 10 days, 3 months, and 6 months, respectively. The residual uptake originated from the pretherapy VOI in 15 of 17 cases. Conclusions: VOI defined by the SUV{sub max}-≥50% isocontour may be a biological target volume for escalated radiation dose.

  10. Single and multiple object tracking using log-euclidean Riemannian subspace and block-division appearance model.

    PubMed

    Hu, Weiming; Li, Xi; Luo, Wenhan; Zhang, Xiaoqin; Maybank, Stephen; Zhang, Zhongfei

    2012-12-01

    Object appearance modeling is crucial for tracking objects, especially in videos captured by nonstationary cameras and for reasoning about occlusions between multiple moving objects. Based on the log-euclidean Riemannian metric on symmetric positive definite matrices, we propose an incremental log-euclidean Riemannian subspace learning algorithm in which covariance matrices of image features are mapped into a vector space with the log-euclidean Riemannian metric. Based on the subspace learning algorithm, we develop a log-euclidean block-division appearance model which captures both the global and local spatial layout information about object appearances. Single object tracking and multi-object tracking with occlusion reasoning are then achieved by particle filtering-based Bayesian state inference. During tracking, incremental updating of the log-euclidean block-division appearance model captures changes in object appearance. For multi-object tracking, the appearance models of the objects can be updated even in the presence of occlusions. Experimental results demonstrate that the proposed tracking algorithm obtains more accurate results than six state-of-the-art tracking algorithms.

  11. Impact of FDG-PET/CT on Radiotherapy Volume Delineation in Non-Small-Cell Lung Cancer and Correlation of Imaging Stage With Pathologic Findings

    SciTech Connect

    Faria, Sergio L. Menard, Sonia; Devic, Slobodan; Sirois, Christian; Souhami, Luis; Lisbona, Robert; Freeman, Carolyn R.

    2008-03-15

    Purpose: Fluorodeoxyglucose-positron emission tomography (FDG-PET)/computed tomography (CT) is more accurate than CT in determining the extent of non-small-cell lung cancer. We performed a study to evaluate the impact of FDG-PET/CT on the radiotherapy volume delineation compared with CT without using any mathematical algorithm and to correlate the findings with the pathologic examination findings. Methods and Materials: A total of 32 patients with proven non-small-cell lung cancer, pathologic specimens from the mediastinum and lung primary, and pretreatment chest CT and FDG-PET/CT scans were studied. For each patient, two data sets of theoretical gross tumor volumes were contoured. One set was determined using the chest CT only, and the second, done separately, was based on the co-registered FDG-PET/CT data. The disease stage of each patient was determined using the TNM staging system for three data sets: the CT scan only, FDG-PET/CT scan, and pathologic findings. Results: Pathologic examination altered the CT-determined stage in 22 (69%) of 32 patients and the PET-determined stage in 16 (50%) of 32 patients. The most significant alterations were related to the N stage. PET altered the TNM stage in 15 (44%) of 32 patients compared with CT alone, but only 7 of these 15 alterations were confirmed by the pathologic findings. With respect to contouring the tumor volume for radiotherapy, PET altered the contour in 18 (56%) of 32 cases compared with CT alone. Conclusion: The contour of the tumor volume of non-small-cell lung cancer patients with co-registered FDG-PET/CT resulted in >50% alterations compared with CT targeting, findings similar to those of other publications. However, the significance of this change is unknown. Furthermore, pathologic examination showed that PET is not always accurate and histologic examination should be obtained to confirm the findings of PET whenever possible.

  12. Human dental arch shape evaluated by euclidean-distance matrix analysis.

    PubMed

    Ferrario, V F; Sforza, C; Miani, A; Tartaglia, G

    1993-04-01

    Form differences between biological structures can be evaluated using several approaches. When landmark data are available, a recently proposed method (euclidean-distance matrix analysis) seems to be able to differentiate between size and shape differences. This method also localizes those areas which differ most between the two structures. We have applied it to analyze the sexual dimorphism in dental arch form in a sample of 50 men and 45 women. Subjects ranged in age between 20 and 27 years, and had sound dentitions. Fourteen landmarks, corresponding to the centers of gravity (centroids) of the occlusal surfaces of all permanent teeth (right second molar to left second molar), were individualized on the dental casts of subjects. All the possible linear distances between pairs of teeth were computed, thus creating four mean form matrices (one for each arch within sex). Gender differences were tested by using euclidean-distance matrix analysis. No significant differences were demonstrated in the shape of arches, while male arches proved to be slightly bigger than female arches.

  13. Loop-erased random walk on a percolation cluster: crossover from Euclidean to fractal geometry.

    PubMed

    Daryaei, E; Rouhani, S

    2014-06-01

    We study loop-erased random walk (LERW) on the percolation cluster, with occupation probability p ≥ p_{c}, in two and three dimensions. We find that the fractal dimensions of LERW_{p} are close to normal LERW in a Euclidean lattice, for all p>p_{c}. However, our results reveal that LERW on critical incipient percolation clusters is fractal with d_{f}=1.217 ± 0.002 for d=2 and 1.43 ± 0.02 for d=3, independent of the coordination number of the lattice. These values are consistent with the known values for optimal path exponents in strongly disordered media. We investigate how the behavior of the LERW_{p} crosses over from Euclidean to fractal geometry by gradually decreasing the value of the parameter p from 1 to p_{c}. For finite systems, two crossover exponents and a scaling relation can be derived. This work opens up a theoretical window regarding the diffusion process on fractal and random landscapes.

  14. Two-stage sparse coding of region covariance via Log-Euclidean kernels to detect saliency.

    PubMed

    Zhang, Ying-Ying; Yang, Cai; Zhang, Ping

    2017-05-01

    In this paper, we present a novel bottom-up saliency detection algorithm from the perspective of covariance matrices on a Riemannian manifold. Each superpixel is described by a region covariance matrix on Riemannian Manifolds. We carry out a two-stage sparse coding scheme via Log-Euclidean kernels to extract salient objects efficiently. In the first stage, given background dictionary on image borders, sparse coding of each region covariance via Log-Euclidean kernels is performed. The reconstruction error on the background dictionary is regarded as the initial saliency of each superpixel. In the second stage, an improvement of the initial result is achieved by calculating reconstruction errors of the superpixels on foreground dictionary, which is extracted from the first stage saliency map. The sparse coding in the second stage is similar to the first stage, but is able to effectively highlight the salient objects uniformly from the background. Finally, three post-processing methods-highlight-inhibition function, context-based saliency weighting, and the graph cut-are adopted to further refine the saliency map. Experiments on four public benchmark datasets show that the proposed algorithm outperforms the state-of-the-art methods in terms of precision, recall and mean absolute error, and demonstrate the robustness and efficiency of the proposed method.

  15. Right ventricular infarction: identification by hemodynamic measurements before and after volume loading and correlation with noninvasive techniques

    SciTech Connect

    Dell'Italia, L.J.; Starling, M.R.; Crawford, M.H.; Boros, B.L.; Chaudhuri, T.K.; O'Rourke, R.A.

    1984-11-01

    To evaluate the potential occurrence of right ventricular infarction, 53 patients with acute inferior transmural myocardial infarction were studied within 36 hours of symptoms by right heart catheterization, equilibrium radionuclide angiography and two-dimensional echocardiography. Technetium-99m pyrophosphate myocardial scintigraphy was performed 3 days after the onset of symptoms. The hemodynamic standard for right ventricular infarction was defined as both a right atrial pressure of 10 mm Hg or more and a right atrial/pulmonary artery wedge pressure ratio of 0.8 or more. Eight (15%) of the 53 patients had hemodynamic measurements at rest characteristic of right ventricular infarction, and 6 (11%) additional patients met these criteria after volume loading. Nineteen (37%) of the 51 patients who had radionuclide angiography had right ventricular dysfunction manifested by both a reduced right ventricular ejection fraction (less than 40%) and right ventricular regional wall motion abnormalities (akinesia or dyskinesia). An abnormal radionuclide angiogram was observed in 12 of 13 patients with hemodynamic measurements indicating right ventricular infarction. In 12 patients with an abnormal radionuclide angiographic study, right ventricular ejection fraction improved 6 to 12 weeks after infarction. Twenty-two (49%) of the 45 patients with adequate two-dimensional echocardiograms had a right ventricular regional wall motion abnormality. An abnormal two-dimensional echocardiogram was seen in 9 of 11 patients with hemodynamic measurements characteristic of right ventricular infarction. Technetium-99m pyrophosphate scintigraphy was positive for right ventricular infarction in 3 of 12 patients who had hemodynamic measurements indicating right ventricular infarction.

  16. Serum levels of GFAP and EGFR in primary and recurrent high-grade gliomas: correlation to tumor volume, molecular markers, and progression-free survival.

    PubMed

    Kiviniemi, Aida; Gardberg, Maria; Frantzén, Janek; Parkkola, Riitta; Vuorinen, Ville; Pesola, Marko; Minn, Heikki

    2015-09-01

    Our aim was to study the association of two potential serum biomarkers glial fibrillary acidic protein (GFAP) and epidermal growth factor receptor (EGFR) with prognostic markers such as IDH1 mutation, tumor burden, and survival in patients with high-grade gliomas (HGG). Additionally, our objective was to evaluate the potential of serum EGFR as a surrogate marker for EGFR status in the tumor. Pre-operative serum samples were prospectively collected from patients with primary (n = 17) or recurrent (n = 10) HGG. Serum GFAP and EGFR levels were determined by ELISA and studied for correlation with molecular markers including EGFR amplification, tumor volume in contrast-enhanced T1-weighted MRI, and progression-free survival (PFS). Pre-operative serum GFAP level of ≥0.014 ng/ml was 86 % sensitive and 85 % specific for the diagnosis of glioblastoma. High GFAP was related to the lack of IDH1 mutation (P = 0.016), high Ki67 proliferation index (P < 0.001), and poor PFS (HR 5.9, CI 1.2-29.9, P = 0.032). Serum GFAP correlated with enhancing tumor volume in primary (r = 0.64 P = 0.005), but also in recurrent HGGs (r = 0.76 P = 0.011). In contrast, serum EGFR levels did not differ between HGG patients and 13 healthy controls, and were not related to EGFR status in the tumor. We conclude that high serum GFAP associates with IDH1 mutation-negative HGG, and poor PFS. Correlation with tumor burden in recurrent HGG implicates the potential of serum GFAP for detection of tumor recurrence. Our results suggest that circulating EGFR is not derived from glioma cells and cannot be used as a marker for EGFR status in the tumor.

  17. Tumour apparent diffusion coefficient is associated with depth of myometrial invasion and is negatively correlated to tumour volume in endometrial carcinomas.

    PubMed

    Husby, J A; Salvesen, Ø O; Magnussen, I J; Trovik, J; Bjørge, L; Salvesen, H B; Haldorsen, I S

    2015-05-01

    To explore possible correlations between tumour apparent diffusion coefficient (ADC), morphological tumour volume, and clinical and histological characteristics in endometrial carcinomas and to evaluate interobserver agreement for preoperative staging by MRI and for ADC measurements. Preoperative conventional MRI including diffusion-weighted imaging (DWI) was performed in 105 endometrial carcinoma patients. Three radiologists independently reviewed the images for the presence of deep myometrial invasion, cervical stromal invasion, and lymph node metastases, and measured tumour ADC in regions of interest (ROIs). ADC values were analysed in relation to histomorphological characteristics and tumour volume. Kappa coefficients (κ) and intraclass correlation coefficients (ICC) for interobserver agreement for MRI staging results and ADC measurements, respectively, were calculated, and receiver operating characteristic (ROC) curves for identification of deep of myometrial invasion were generated. Mean tumour ADC was significantly lower in tumours with deep myometrial invasion (ADC = 0.75 × 10(-3) mm(2)/s) compared to tumours with superficial or no myometrial invasion (ADC = 0.85 × 10(-3) mm(2)/s; p < 0.001). ADC was negatively correlated to tumour size (p = 0.007). The interobserver agreement was fair (κ = 0.32) for depth of myometrial invasion, good for cervical stromal invasion (κ = 0.66), and moderate for lymph node metastases (κ = 0.54), and the interobserver variability for ADC value measurements was low (ICC = 0.60). Tumour ADC measurements may in the future provide an adjunct tool, aiding in the preoperative identification of high-risk patients with deep myometrial infiltration. Copyright © 2015 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

  18. A simplified procedure for correcting both errors and erasures of a Reed-Solomon code using the Euclidean algorithm

    NASA Technical Reports Server (NTRS)

    Truong, T. K.; Hsu, I. S.; Eastman, W. L.; Reed, I. S.

    1987-01-01

    It is well known that the Euclidean algorithm or its equivalent, continued fractions, can be used to find the error locator polynomial and the error evaluator polynomial in Berlekamp's key equation needed to decode a Reed-Solomon (RS) code. A simplified procedure is developed and proved to correct erasures as well as errors by replacing the initial condition of the Euclidean algorithm by the erasure locator polynomial and the Forney syndrome polynomial. By this means, the errata locator polynomial and the errata evaluator polynomial can be obtained, simultaneously and simply, by the Euclidean algorithm only. With this improved technique the complexity of time domain RS decoders for correcting both errors and erasures is reduced substantially from previous approaches. As a consequence, decoders for correcting both errors and erasures of RS codes can be made more modular, regular, simple, and naturally suitable for both VLSI and software implementation. An example illustrating this modified decoding procedure is given for a (15, 9) RS code.

  19. White and Gray Matter Volume Changes and Correlation with Visual Evoked Potential in Patients with Optic Neuritis: A Voxel-Based Morphometry Study.

    PubMed

    Huang, Xin; Zhang, Qiang; Hu, Pei-Hong; Zhong, Yu-Lin; Zhang, Ying; Wei, Rong; Xu, Ting-Ting; Shao, Yi

    2016-04-05

    The aim of this study was to investigate potential morphological alterations of gray and white matter in patients with optic neuritis (ON) and their relationship with behavioral performance, using voxel-based morphometry (VBM). Twelve (4 males, 8 females) patients with ON and 12 (4 males, 8 females) age-, sex-, and education-matched healthy controls (HCs) underwent magnetic resonance imaging (MRI). Imaging data were analyzed using two-sample t tests to identify group differences in gray and white matter volume (GMV, WMV). Correlation analysis was used to explore relationships between observed GMV and WMV of different areas and visual evoked potential (VEP) in ON. Compared with HCs, ON patients had: significantly decreased GMV in the left postcentral gyrus, left inferior frontal gyrus, left anterior cingulate, left and right middle frontal gyrus, and right inferior parietal lobule; decreased WMV in the left middle frontal gyrus, right superior frontal gyrus, left precentral gyrus and right inferior parietal lobule; and increased WMV in the left fusiform gyrus and left inferior parietal lobule. VEP latency of the right eye in ON correlated positively with WMV signal value of the left fusiform gyrus (r=0.726, p=0.008), and negatively with GMV signal value of the right inferior parietal lobule (r=-0.611, p=0.035). Duration of ON correlated negatively with WMV signal value of the right superior frontal gyrus (r=-0.662, p=0.019), while best-corrected visual acuity (VA) of the right eye correlated negatively with WMV signal value of the left middle frontal gyrus (r=-0.704, p=0.011). These results suggest significant brain involvement in ON, which may reflect the underlying pathologic mechanism. Correlational results demonstrate that VEP in ON is closely associated with WMV and GMV atrophy in many brain regions.

  20. Correlations between renal function and the total kidney volume measured on imaging for autosomal dominant polycystic kidney disease: A systematic review and meta-analysis.

    PubMed

    Jo, Woo Ri; Kim, Seong Hee; Kim, Kyung Won; Suh, Chong Hyun; Kim, Jeong Kon; Kim, Hyosang; Lee, Jong Gu; Oh, Woo Yong; Choi, Seong Eun; Pyo, Junhee

    2017-10-01

    To provide a systematic summary of total kidney volume (TKV) as an imaging biomarker in clinical trials for autosomal dominant polycystic kidney disease (ADPKD), focusing on the correlation between TKV and renal function. A computerized literature search was performed using MEDLINE and EMBASE databases for studies that evaluated the correlation between TKV and the glomerular filtration rate (GFR) and between the TKV growth rate and GFR decline rate. A meta-analysis was performed to generate the summary correlation coefficient (r). A qualitative review was performed to evaluate the characteristics of TKV as an imaging biomarker. Eighteen articles including a total sample size of 2835 patients were retrieved. Meta-analysis revealed substantial correlations between TKV and GFR [r, -0.520; 95% confidence interval (CI), -0.60 to -0.43] and between the TKV growth rate and GFR decline rate [r, -0.320; 95% CI, -0.54 to -0.10]. The quantitative review revealed that baseline TKV can affect the TKV growth rate and GFR decline rate, such that patients with a higher baseline TKV showed faster TKV growth and GFR decline. There was significant variability in image acquisition and analysis methods. There were significant negative correlations between TKV and GFR as well as between TKV growth and GFR decline rates, suggesting that TKV imaging is a useful biomarker in clinical trials. However, standardization-or at least trial-specific standardization-of image acquisition and analysis techniques is required to use TKV as a reliable biomarker. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Correlations among residual multiparticle entropy, local atomic-level pressure, free volume and the phase-ordering rule in several liquids.

    PubMed

    Cao, Qi-Long; Wang, Wei-Lu; Li, Y D; Liu, C S

    2011-01-28

    A modified Wang-Landau density-of-states sampling approach has been performed to calculate the excess entropy of liquid metals, Lennard-Jones (LJ) system and liquid Si under NVT conditions; and it is then the residual multiparticle entropy (S(RMPE)) is obtained by subtraction of the pair correlation entropy. The temperature dependence of S(RMPE) has been investigated along with the temperature dependence of the local atomic-level pressure and the pair correlation functions. Our results suggest that the temperature dependence of the pair correlation entropy is well described by T(-1) scaling while T(-0.4) scaling well describes the relationship between the excess entropy and temperature. For liquid metals and LJ system, the -S(RMPE) versus temperature curves show positive correlations and the -S(RMPE) of liquid Si is shown to have a negative correlation with temperature, the phase-ordering criterion (based on the S(RMPE)) for predicting freezing transition works in liquid metals and LJ but fails in liquid Si. The local atomic-level pressure scaled with the virial pressure (σ(al)/σ(av)) exhibits the much similar temperature dependence as -S(RMPE) for all studied systems, even though simple liquid metals and liquid Si exhibit opposite temperature dependence in both σ(al)/σ(av) and -S(RMPE). The further analysis shows that the competing properties of the two effects due to localization and free volume on the S(RMPE) exist in simple liquid metals and LJ system but disappear in liquid Si, which may be the critical reason of the failure of the phase-ordering criterion in liquid Si.

  2. White and Gray Matter Volume Changes and Correlation with Visual Evoked Potential in Patients with Optic Neuritis: A Voxel-Based Morphometry Study

    PubMed Central

    Huang, Xin; Zhang, Qiang; Hu, Pei-Hong; Zhong, Yu-Lin; Zhang, Ying; Wei, Rong; Xu, Ting-Ting; Shao, Yi

    2016-01-01

    Background The aim of this study was to investigate potential morphological alterations of gray and white matter in patients with optic neuritis (ON) and their relationship with behavioral performance, using voxel-based morphometry (VBM). Material/Methods Twelve (4 males, 8 females) patients with ON and 12 (4 males, 8 females) age-, sex-, and education-matched healthy controls (HCs) underwent magnetic resonance imaging (MRI). Imaging data were analyzed using two-sample t tests to identify group differences in gray and white matter volume (GMV, WMV). Correlation analysis was used to explore relationships between observed GMV and WMV of different areas and visual evoked potential (VEP) in ON. Results Compared with HCs, ON patients had: significantly decreased GMV in the left postcentral gyrus, left inferior frontal gyrus, left anterior cingulate, left and right middle frontal gyrus, and right inferior parietal lobule; decreased WMV in the left middle frontal gyrus, right superior frontal gyrus, left precentral gyrus and right inferior parietal lobule; and increased WMV in the left fusiform gyrus and left inferior parietal lobule. VEP latency of the right eye in ON correlated positively with WMV signal value of the left fusiform gyrus (r=0.726, p=0.008), and negatively with GMV signal value of the right inferior parietal lobule (r=−0.611, p=0.035). Duration of ON correlated negatively with WMV signal value of the right superior frontal gyrus (r=−0.662, p=0.019), while best-corrected visual acuity (VA) of the right eye correlated negatively with WMV signal value of the left middle frontal gyrus (r=−0.704, p=0.011). Conclusions These results suggest significant brain involvement in ON, which may reflect the underlying pathologic mechanism. Correlational results demonstrate that VEP in ON is closely associated with WMV and GMV atrophy in many brain regions. PMID:27045330

  3. [Clopidogrel resistance of patients with coronary artery disease and its correlation with platelet count and mean platelet volume].

    PubMed

    Li, Lei; Han, Jiang-li; Li, Hai-yan; Qiao, Rui; Yu, Hai-yi; Zhang, Jie; Gao, Wei

    2013-03-26

    To explore the association between clopidogrel resistance (CR) as assessed by whole blood electrical impedance aggregometry (EIA) and platelet parameters. The prospective study comprised 152 patients with coronary artery disease (CAD) on the therapy of clopidogrel. EIA employed adenosine diphosphate (ADP) as an inductor to measure platelet aggregation. CR was defined by spontaneous aggregation (electrical impedance ≥ 10 Ω). The subjects were divided into 2 groups of CR and clopidogrel sensitive (CS). Platelet parameters were measured by routine blood test. And their clinical data and outcomes were analyzed. The prevalence of CR was 10.5% (n = 16). The ratio of patients with diabetes in CR group was higher than that in CS group (7/16 vs 29/136, P = 0.046). Platelet counts and mean platelet volume (MPV) were also higher in CR group than those in CS group ((241 ± 58) ×10(9)/L vs (185 ± 56)×10(9)/L, (8.0 ± 0.8) fl vs (7.4 ± 0.9) fl, both P < 0.05). Logistic regression indicated each 10×10(9)/L increase in platelet and each 1 fl increase in MVP were associated with 0.376 and 1.015 folds increase in CR onset respectively (OR = 1.376, 95%CI 1.097 - 1.725, P = 0.006;OR = 2.015, 95%CI 1.148 - 3.537, P = 0.015). The patients with CR had more cardiovascular events during an average follow-up of 53 months (6/16 vs 23/136, P = 0.047). CAD patients with CR had higher incidence of cardiovascular events. Increased platelet counts and MPV levels are independent predictors for CR in CAD patients.

  4. The Gray Matter Volume of the Amygdala Is Correlated with the Perception of Melodic Intervals: A Voxel-Based Morphometry Study

    PubMed Central

    Li, Xueting; Beuckelaer, Alain De; Guo, Jiahui; Ma, Feilong; Xu, Miao; Liu, Jia

    2014-01-01

    Music is not simply a series of organized pitches, rhythms, and timbres, it is capable of evoking emotions. In the present study, voxel-based morphometry (VBM) was employed to explore the neural basis that may link music to emotion. To do this, we identified the neuroanatomical correlates of the ability to extract pitch interval size in a music segment (i.e., interval perception) in a large population of healthy young adults (N = 264). Behaviorally, we found that interval perception was correlated with daily emotional experiences, indicating the intrinsic link between music and emotion. Neurally, and as expected, we found that interval perception was positively correlated with the gray matter volume (GMV) of the bilateral temporal cortex. More important, a larger GMV of the bilateral amygdala was associated with better interval perception, suggesting that the amygdala, which is the neural substrate of emotional processing, is also involved in music processing. In sum, our study provides one of first neuroanatomical evidence on the association between the amygdala and music, which contributes to our understanding of exactly how music evokes emotional responses. PMID:24923421

  5. Comparison of the linear finite element prediction of deformation and strain of human cancellous bone to 3D digital volume correlation measurements.

    PubMed

    Zauel, R; Yeni, Y N; Bay, B K; Dong, X N; Fyhrie, D P

    2006-02-01

    The mechanical properties of cancellous bone and the biological response of the tissue to mechanical loading are related to deformation and strain in the trabeculae during function. Due to the small size of trabeculae, their motion is difficult to measure. To avoid the need to measure trabecular motions during loading the finite element method has been used to estimate trabecular level mechanical deformation. This analytical approach has been empirically successful in that the analytical models are solvable and their results correlate with the macroscopically measured stiffness and strength of bones. The present work is a direct comparison of finite element predictions to measurements of the deformation and strain at near trabecular level. Using the method of digital volume correlation, we measured the deformation and calculated the strain at a resolution approaching the trabecular level for cancellous bone specimens loaded in uniaxial compression. Smoothed results from linearly elastic finite element models of the same mechanical tests were correlated to the empirical three-dimensional (3D) deformation in the direction of loading with a coefficient of determination as high as 97% and a slope of the prediction near one. However, real deformations in the directions perpendicular to the loading direction were not as well predicted by the analytical models. Our results show, that the finite element modeling of the internal deformation and strain in cancellous bone can be accurate in one direction but that this does not ensure accuracy for all deformations and strains.

  6. Importance of using physiologically relevant volume of dissolution medium to correlate the oral exposure of formulations of BMS-480188 mesylate.

    PubMed

    Gu, Chong-Hui; Gandhi, Rajesh B; Tay, Lee K; Zhou, Simon; Raghavan, Krishnaswamy

    2004-01-09

    BMS-480188 is a weak base. The aqueous solubility of BMS-480188 is 0.036 mg/ml at pH 6.5 at 37 degrees C. The mesylate salt of BMS-480188 was prepared to improve its solubility. Capsules containing mesylate salt alone (Formulation A) or mesylate salt with excipients, including lactose, croscarmellose sodium, sodium lauryl sulfate, syloid and magnesium stearate (Formulation B), were prepared. Both formulations show similar dissolution profiles in 1l 0.01N HCl at 37 degrees C. However, the bioavailability of Formulations A and B is 5.7 and 24%, respectively, in monkeys. Since very small amount of fluid is available in the stomach of monkeys in fasted state, 30 ml of 0.01N HCl was used as the dissolution medium to simulate the ratio of the drug to dissolution medium in vivo. The dissolution studies in 30 ml of 0.01N HCl show that the amount of drug dissolved from the Formulation B is 80% greater than the Formulation A after 2h. These results are consistent with the higher bioavailability of the formulated capsules. The pK(a) of the free base is 3.0 and the apparent solubility of the mesylate salt (>20mg/ml) is much greater than the equilibrium solubility of BMS-480188 (1.08 mg/ml) in 0.01N HCl at 37 degrees C. Therefore, the mesylate salt of BMS-480188 converts to the free base in 0.01N HCl. The presence of excipients delays the conversion of the mesylate salt to the free base in the dissolution test using 30 ml medium, leading to a greater percentage of the dissolved drugs. This inhibitory effect of excipients is masked during the dissolution using 1l medium because the concentration of the dissolved drug is below the solubility limit of BMS-480188. This study demonstrates the importance of the volume of the dissolution medium for the in vitro dissolution test to qualitatively predict the bioavailability of a salt of weak base with low intrinsic aqueous solubility.

  7. Euclidean Distances as measures of speaker similarity including identical twin pairs: A forensic investigation using source and filter voice characteristics.

    PubMed

    San Segundo, Eugenia; Tsanas, Athanasios; Gómez-Vilda, Pedro

    2017-01-01

    There is a growing consensus that hybrid approaches are necessary for successful speaker characterization in Forensic Speaker Comparison (FSC); hence this study explores the forensic potential of voice features combining source and filter characteristics. The former relate to the action of the vocal folds while the latter reflect the geometry of the speaker's vocal tract. This set of features have been extracted from pause fillers, which are long enough for robust feature estimation while spontaneous enough to be extracted from voice samples in real forensic casework. Speaker similarity was measured using standardized Euclidean Distances (ED) between pairs of speakers: 54 different-speaker (DS) comparisons, 54 same-speaker (SS) comparisons and 12 comparisons between monozygotic twins (MZ). Results revealed that the differences between DS and SS comparisons were significant in both high quality and telephone-filtered recordings, with no false rejections and limited false acceptances; this finding suggests that this set of voice features is highly speaker-dependent and therefore forensically useful. Mean ED for MZ pairs lies between the average ED for SS comparisons and DS comparisons, as expected according to the literature on twin voices. Specific cases of MZ speakers with very high ED (i.e. strong dissimilarity) are discussed in the context of sociophonetic and twin studies. A preliminary simplification of the Vocal Profile Analysis (VPA) Scheme is proposed, which enables the quantification of voice quality features in the perceptual assessment of speaker similarity, and allows for the calculation of perceptual-acoustic correlations. The adequacy of z-score normalization for this study is also discussed, as well as the relevance of heat maps for detecting the so-called phantoms in recent approaches to the biometric menagerie.

  8. Correlation between mesopore volume of carbon supports and the immobilization of laccase from Trametes versicolor for the decolorization of Acid Orange 7.

    PubMed

    Ramírez-Montoya, Luis A; Hernández-Montoya, Virginia; Montes-Morán, Miguel A; Cervantes, Francisco J

    2015-10-01

    Immobilization of laccase from Trametes versicolor was carried out using carbon supports prepared from different lignocellulosic wastes. Enzymes were immobilized by physical adsorption. Taguchi methodology was selected for the design of experiments regarding the preparation of the carbon materials, which included the use of activating agents for the promotion of mesoporosity. A good correlation between the mesopore volumes of the carbon supports and the corresponding laccase loadings attained was observed. Specifically, the chemical activation of pecan nut shell with FeCl3 led to a highly mesoporous material that also behaved as the most efficient support for the immobilization of laccase. This particular laccase/carbon support system was used as biocatalyst for the decolorization of aqueous solutions containing Acid Orange 7. Mass spectrometry coupled to a liquid chromatograph allowed us to identify the products of the dye degradation. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Correlation of the extent of tumor volume resection and patient survival in surgery of glioblastoma multiforme with high-field intraoperative MRI guidance.

    PubMed

    Kuhnt, Daniela; Becker, Andreas; Ganslandt, Oliver; Bauer, Miriam; Buchfelder, Michael; Nimsky, Christopher

    2011-12-01

    Extent of resection (EOR) still remains controversial in therapy of glioblastoma multiforme (GBM). However, an increasing number of studies favor maximum EOR as being associated with longer patient survival. One hundred thirty-five GBM patients underwent tumor resection aided by 1.5T intraoperative MRI (iMRI) and integrated multimodal navigation. Tumor volume was quantified by manual segmentation. The influences of EOR, patient age, recurrent tumor, tumor localization, and gender on survival time were examined. Intraoperative MRI detected residual tumor volume in 88 patients. In 19 patients surgery was continued; further resection resulted in final gross total resection (GTR) for 9 patients (GTR increased from 47 [34.80%] to 56 [41.49%] patients). Tumor volumes were significantly reduced from 34.25 ± 23.68% (first iMRI) to 1.22 ± 16.24% (final iMRI). According to Kaplan-Meier estimates, median survival was 14 months (95% confidence interval [CI]: 11.7-16.2) for EOR ≥ 98% and 9 months (95% CI: 7.4-10.5) for EOR <98% (P< .0001); it was 9 months (95% CI: 7.3-10.7) for patients ≥ 65 years and 12 months (95% CI: 8.4-15.6) for patients <65 years (P < .05). Multivariate analysis showed a hazard ratio of 0.39 (95% CI: 0.24-0.63; P = .001) for EOR ≥ 98% and 0.61 (95% CI: 0.38-0.97; P < .05) for patient age <65 years. To our knowledge, this is the largest study including correlation of iMRI, tumor volumetry, and survival time. We demonstrate that navigation guidance and iMRI significantly contribute to optimal EOR with low postoperative morbidity, where EOR ≥ 98% and patient age <65 years are associated with significant survival advantages. Thus, maximum EOR should be the surgical goal in GBM surgery while preserving neurological function.

  10. Dose-volume correlation of cumulative vaginal doses and late toxicity after adjuvant external radiation and brachytherapy for cervical cancer.

    PubMed

    Singh, Roshni; Chopra, Supriya; Engineer, Reena; Paul, Siji; Kannan, Sadhana; Mohanty, Sarthak; Swamidas, Jamema; Mahantshetty, Umesh; Ghosh, Jaya; Maheshwari, Amita; Shylasree, T Surappa; Kerkar, Rajendra; Gupta, Sudeep; Shrivastava, Shyam

    To investigate dose-response relationship between vaginal doses and long-term morbidity. Patients receiving adjuvant pelvic (chemo) radiation and brachytherapy for cervical cancer from January 2011 to December 2014 were included. Baseline vaginal length was determined clinically and from imaging at BT planning. Dose points were defined along mucosa and at 5 mm depth at 12, 3, 6, and 9 'o' clock positions at every 2 cm from apex to introitus. Cumulative equivalent doses in 2 Gy were calculated. Vaginal stenosis was reported in reference to baseline length according to CTCAE version 3.0. Receiver operator characteristics curve was used to identify dose thresholds for univariate and multivariate analysis. Overall, 78 women with median age of 49 (32-71) years were included. The median dose at vaginal apex mucosa and 5 mm depth was 118 Gy3 (78-198) and 81 Gy3 (70-149) respectively. At median follow-up of 36 (18-60) months, vaginal stenosis ≥25%, and grade ≥ II telangiectasia was observed in 33.3% and 45.7%, respectively. On receiver operator characteristics analysis, apical mucosal dose >142 Gy3 and recto-vaginal point dose >86 Gy3 predicted for stenosis on univariate (p = 0.02, p = 0.06) and multivariate analysis (p = 0.04). The probability of stenosis increased from 32% at 70 Gy3, 38% at 80 Gy3, and 45% at 90 Gy3 rectovaginal point dose. No correlation was observed between vaginal doses and telangiectasia and vaginal stenosis and sexual quality of life. Vaginal apex mucosal dose >142 Gy3 independently predicts for vaginal stenosis. Copyright © 2017 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

  11. Archaeal community structure in leachate and solid waste is correlated to methane generation and volume reduction during biodegradation of municipal solid waste.

    PubMed

    Fei, Xunchang; Zekkos, Dimitrios; Raskin, Lutgarde

    2015-02-01

    Duplicate carefully-characterized municipal solid waste (MSW) specimens were reconstituted with waste constituents obtained from a MSW landfill and biodegraded in large-scale landfill simulators for about a year. Repeatability and relationships between changes in physical, chemical, and microbial characteristics taking place during the biodegradation process were evaluated. Parameters such as rate of change of soluble chemical oxygen demand in the leachate (rsCOD), rate of methane generation (rCH4), rate of specimen volume reduction (rVt), DNA concentration in the leachate, and archaeal community structures in the leachate and solid waste were monitored during operation. The DNA concentration in the leachate was correlated to rCH4 and rVt. The rCH4 was related to rsCOD and rVt when waste biodegradation was intensive. The structures of archaeal communities in the leachate and solid waste of both simulators were very similar and Methanobacteriaceae were the dominant archaeal family throughout the testing period. Monitoring the chemical and microbial characteristics of the leachate was informative of the biodegradation process and volume reduction in the simulators, suggesting that leachate monitoring could be informative of the extent of biodegradation in a full-scale landfill.

  12. Noise exposure modulates cochlear inner hair cell ribbon volumes, correlating with changes in auditory measures in the FVB/nJ mouse

    PubMed Central

    Paquette, Stephen T.; Gilels, Felicia; White, Patricia M.

    2016-01-01

    Cochlear neuropathy resulting from unsafe noise exposure is a life altering condition that affects many people. This hearing dysfunction follows a conserved mechanism where inner hair cell synapses are lost, termed cochlear synaptopathy. Here we investigate cochlear synaptopathy in the FVB/nJ mouse strain as a prelude for the investigation of candidate genetic mutations for noise damage susceptibility. We used measurements of auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) to assess hearing recovery in FVB/nJ mice exposed to two different noise levels. We also utilized confocal fluorescence microscopy in mapped whole mount cochlear tissue, in conjunction with deconvolution and three-dimensional modeling, to analyze numbers, volumes and positions of paired synaptic components. We find evidence for significant synapse reorganization in response to both synaptopathic and sub-synaptopathic noise exposures in FVB/nJ. Specifically, we find that the modulation in volume of very small synaptic ribbons correlates with the presence of reduced ABR peak one amplitudes in both levels of noise exposures. These experiments define the use of FVB/nJ mice for further genetic investigations into the mechanisms of noise damage. They further suggest that in the cochlea, neuronal-inner hair cell connections may dynamically reshape as part of the noise response. PMID:27162161

  13. Noise exposure modulates cochlear inner hair cell ribbon volumes, correlating with changes in auditory measures in the FVB/nJ mouse.

    PubMed

    Paquette, Stephen T; Gilels, Felicia; White, Patricia M

    2016-05-10

    Cochlear neuropathy resulting from unsafe noise exposure is a life altering condition that affects many people. This hearing dysfunction follows a conserved mechanism where inner hair cell synapses are lost, termed cochlear synaptopathy. Here we investigate cochlear synaptopathy in the FVB/nJ mouse strain as a prelude for the investigation of candidate genetic mutations for noise damage susceptibility. We used measurements of auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) to assess hearing recovery in FVB/nJ mice exposed to two different noise levels. We also utilized confocal fluorescence microscopy in mapped whole mount cochlear tissue, in conjunction with deconvolution and three-dimensional modeling, to analyze numbers, volumes and positions of paired synaptic components. We find evidence for significant synapse reorganization in response to both synaptopathic and sub-synaptopathic noise exposures in FVB/nJ. Specifically, we find that the modulation in volume of very small synaptic ribbons correlates with the presence of reduced ABR peak one amplitudes in both levels of noise exposures. These experiments define the use of FVB/nJ mice for further genetic investigations into the mechanisms of noise damage. They further suggest that in the cochlea, neuronal-inner hair cell connections may dynamically reshape as part of the noise response.

  14. Existence and blowup results for asymptotically Euclidean initial data sets generated by the conformal method

    NASA Astrophysics Data System (ADS)

    Dilts, James; Isenberg, James

    2016-11-01

    For each set of (freely chosen) seed data, the conformal method reduces the Einstein constraint equations to a system of elliptic equations, the conformal constraint equations. We prove an admissibility criterion, based on a (conformal) prescribed scalar curvature problem, which provides a necessary condition on the seed data for the conformal constraint equations to (possibly) admit a solution. We then consider sets of asymptotically Euclidean (AE) seed data for which solutions of the conformal constraint equations exist, and examine the blowup properties of these solutions as the seed data sets approach sets for which no solutions exist. We also prove that there are AE seed data sets which include a Yamabe nonpositive metric and lead to solutions of the conformal constraints. These data sets allow the mean curvature function to have 0's.

  15. Application of Euclidean distance measurement and principal component analysis for gene identification.

    PubMed

    Ghosh, Antara; Barman, Soma

    2016-06-01

    Gene systems are extremely complex, heterogeneous, and noisy in nature. Many statistical tools which are used to extract relevant feature from genes provide fuzzy and ambiguous information. High-dimensional gene expression database available in public domain usually contains thousands of genes. Efficient prediction method is demanding nowadays for accurate identification of such database. Euclidean distance measurement and principal component analysis methods are applied on such databases to identify the genes. In both methods, prediction algorithm is based on homology search approach. Digital Signal Processing technique along with statistical method is used for analysis of genes in both cases. A two-level decision logic is used for gene classification as healthy or cancerous. This binary logic minimizes the prediction error and improves prediction accuracy. Superiority of the method is judged by receiver operating characteristic curve.

  16. A lower bound on the minimum Euclidean distance of trellis-coded modulation schemes

    NASA Technical Reports Server (NTRS)

    Rouanne, Marc; Costello, Daniel J., Jr.

    1988-01-01

    A lower bound on the minimum free Euclidean distance of trellis-coded modulation (TCM) is derived that guarantees the existence of good TCM codes of any complexity. The bound is used to compare trellis codes combined with phase-shift keying, pulse amplitude modulation, and quadrature amplitude-shift keying modulation. This random coding bound is the first lower bound on the free distance of trellis codes, is tighter than any upper bound for large constraint lengths, and predicts the asymptotic performance of TCM when the complexity of the code becomes large. The bound can be used with any code rate and any modulation scheme and shows that the free distance increases linearly with the constraint length for large values of the constraint length.

  17. Hadronic vacuum polarization in QCD and its evaluation in Euclidean spacetime

    NASA Astrophysics Data System (ADS)

    de Rafael, Eduardo

    2017-07-01

    We discuss a new technique to evaluate integrals of QCD Green's functions in the Euclidean based on their Mellin-Barnes representation. We present as a first application the evaluation of the lowest order hadronic vacuum polarization (HVP) contribution to the anomalous magnetic moment of the muon 1/2 (gμ-2 )HVP≡aμHVP . It is shown that with a precise determination of the slope and curvature of the HVP function at the origin from lattice QCD (LQCD), one can already obtain a result for aμHVP which may serve as a test of the determinations based on experimental measurements of the e+e- annihilation cross section into hadrons.

  18. Euclidean path integral formalism in deformed space with minimum measurable length

    NASA Astrophysics Data System (ADS)

    Bernardo, Reginald Christian S.; Esguerra, Jose Perico H.

    2017-04-01

    We study time-evolution at the quantum level by developing the Euclidean path-integral approach for the general case where there exists a minimum measurable length. We derive an expression for the momentum-space propagator which turns out to be consistent with recently developed β-canonical transformation. We also construct the propagator for maximal localization which corresponds to the amplitude that a state which is maximally localized at location ξ' propagates to a state which is maximally localized at location ξ″ in a given time. Our expression for the momentum-space propagator and the propagator for maximal localization is valid for any form of time-independent Hamiltonian. The nonrelativistic free particle, particle in a linear potential, and the harmonic oscillator are discussed as examples.

  19. Unstable spiral waves and local Euclidean symmetry in a model of cardiac tissue

    SciTech Connect

    Marcotte, Christopher D.; Grigoriev, Roman O.

    2015-06-15

    This paper investigates the properties of unstable single-spiral wave solutions arising in the Karma model of two-dimensional cardiac tissue. In particular, we discuss how such solutions can be computed numerically on domains of arbitrary shape and study how their stability, rotational frequency, and spatial drift depend on the size of the domain as well as the position of the spiral core with respect to the boundaries. We also discuss how the breaking of local Euclidean symmetry due to finite size effects as well as the spatial discretization of the model is reflected in the structure and dynamics of spiral waves. This analysis allows identification of a self-sustaining process responsible for maintaining the state of spiral chaos featuring multiple interacting spirals.

  20. Estimating the chromatic numbers of Euclidean space by convex minimization methods

    SciTech Connect

    Gorskaya, Elena S; Mitricheva, Irina M; Protasov, Vladimir Yu; Raigorodskii, Andrei M

    2009-06-30

    The chromatic numbers of the Euclidean space R{sup n} with k forbidden distances are investigated (that is, the minimum numbers of colours necessary to colour all points in R{sup n} so that no two points of the same colour lie at a forbidden distance from each other). Estimates for the growth exponents of the chromatic numbers as n{yields}{infinity} are obtained. The so-called linear algebra method which has been developed is used for this. It reduces the problem of estimating the chromatic numbers to an extremal problem. To solve this latter problem a fundamentally new approach is used, which is based on the theory of convex extremal problems and convex analysis. This allows the required estimates to be found for any k. For k{<=}20 these estimates are found explicitly; they are the best possible ones in the framework of the method mentioned above. Bibliography: 18 titles.

  1. Non-perturbative BRST quantization of Euclidean Yang-Mills theories in Curci-Ferrari gauges

    NASA Astrophysics Data System (ADS)

    Pereira, A. D.; Sobreiro, R. F.; Sorella, S. P.

    2016-10-01

    In this paper we address the issue of the non-perturbative quantization of Euclidean Yang-Mills theories in the Curci-Ferrari gauge. In particular, we construct a refined Gribov-Zwanziger action for this gauge, which takes into account the presence of gauge copies as well as the dynamical formation of dimension-two condensates. This action enjoys a non-perturbative BRST symmetry recently proposed in Capri et al. (Phys. Rev. D 92(4), 045039. doi: 10.1103/PhysRevD.92.045039 arXiv:1506.06995 [hep-th], 2015). Finally, we pay attention to the gluon propagator in different space-time dimensions.

  2. A Log-Euclidean polyaffine registration for articulated structures in medical images.

    PubMed

    Martín-Fernández, Miguel Angel; Martín-Fernández, Marcos; Alberola-López, Carlos

    2009-01-01

    In this paper we generalize the Log-Euclidean polyaffine registration framework of Arsigny et al. to deal with articulated structures. This framework has very useful properties as it guarantees the invertibility of smooth geometric transformations. In articulated registration a skeleton model is defined for rigid structures such as bones. The final transformation is affine for the bones and elastic for other tissues in the image. We extend the Arsigny el al.'s method to deal with locally-affine registration of pairs of wires. This enables the possibility of using this registration framework to deal with articulated structures. In this context, the design of the weighting functions, which merge the affine transformations defined for each pair of wires, has a great impact not only on the final result of the registration algorithm, but also on the invertibility of the global elastic transformation. Several experiments, using both synthetic images and hand radiographs, are also presented.

  3. Artificial immune system via Euclidean Distance Minimization for anomaly detection in bearings

    NASA Astrophysics Data System (ADS)

    Montechiesi, L.; Cocconcelli, M.; Rubini, R.

    2016-08-01

    In recent years new diagnostics methodologies have emerged, with particular interest into machinery operating in non-stationary conditions. In fact continuous speed changes and variable loads make non-trivial the spectrum analysis. A variable speed means a variable characteristic fault frequency related to the damage that is no more recognizable in the spectrum. To overcome this problem the scientific community proposed different approaches listed in two main categories: model-based approaches and expert systems. In this context the paper aims to present a simple expert system derived from the mechanisms of the immune system called Euclidean Distance Minimization, and its application in a real case of bearing faults recognition. The proposed method is a simplification of the original process, adapted by the class of Artificial Immune Systems, which proved to be useful and promising in different application fields. Comparative results are provided, with a complete explanation of the algorithm and its functioning aspects.

  4. ILP, the Blind, and the Elephant: Euclidean Embedding of Co-proven Queries

    NASA Astrophysics Data System (ADS)

    Schulz, Hannes; Kersting, Kristian; Karwath, Andreas

    Relational data is complex. This complexity makes one of the basic steps of ILP difficult: understanding the data and results. If the user cannot easily understand it, he draws incomplete conclusions. The situation is very much as in the parable of the blind men and the elephant that appears in many cultures. In this tale the blind work independently and with quite different pieces of information, thereby drawing very different conclusions about the nature of the beast. In contrast, visual representations make it easy to shift from one perspective to another while exploring and analyzing data. This paper describes a method for embedding interpretations and queries into a single, common Euclidean space based on their co-proven statistics. We demonstrate our method on real-world datasets showing that ILP results can indeed be captured at a glance.

  5. Unstable spiral waves and local Euclidean symmetry in a model of cardiac tissue

    NASA Astrophysics Data System (ADS)

    Marcotte, Christopher D.; Grigoriev, Roman O.

    2015-06-01

    This paper investigates the properties of unstable single-spiral wave solutions arising in the Karma model of two-dimensional cardiac tissue. In particular, we discuss how such solutions can be computed numerically on domains of arbitrary shape and study how their stability, rotational frequency, and spatial drift depend on the size of the domain as well as the position of the spiral core with respect to the boundaries. We also discuss how the breaking of local Euclidean symmetry due to finite size effects as well as the spatial discretization of the model is reflected in the structure and dynamics of spiral waves. This analysis allows identification of a self-sustaining process responsible for maintaining the state of spiral chaos featuring multiple interacting spirals.

  6. Distributed stochastic multi-vehicle routing in the Euclidean plane with no communications

    NASA Astrophysics Data System (ADS)

    Pietrabissa, Antonio

    2016-08-01

    This paper presents an algorithm for the multi-vehicle routing problem with no communications among the vehicles. The scenario consists in a convex Euclidean mission space, where targets are generated according to a Poisson distribution in time and to a generic continuous spatial distribution. The targets must be visited by the vehicles, which, therefore, must act in coordination. Even if no communications are required, the proposed routing strategy succeeds in effectively partitioning the mission space among the vehicles: at low target generation rates, the algorithm leads to the well-known centroidal Voronoi tessellation, whereas at high target generation rates, simulation results show that it has better performances with respect to a reference algorithm with no communications among vehicles.

  7. Emergence of Spontaneous Twist and Curvature in Non-Euclidean Rods: Application to Erodium Plant Cells

    NASA Astrophysics Data System (ADS)

    Aharoni, Hillel; Abraham, Yael; Elbaum, Rivka; Sharon, Eran; Kupferman, Raz

    2012-06-01

    We present a limiting model for thin non-Euclidean elastic rods. Originating from the three-dimensional (3D) reference metric of the rod, which is determined by its internal material structure, we derive a 1D reduced rod theory. Specifically, we show how the spontaneous twist and curvature of a rod emerge from the reference metric derivatives. Thus, the model allows calculating the unconstrained equilibrium configuration of a thin rod directly from its internal structure. The model is applied to the study of cells from members of the Geraniaceae plant family and their configurational response to dehydration. We show how the geometrical arrangement of cellulose fibrils on the cell walls determines the helical shapes of isolated cells.

  8. The Euclidean gravitational action as black hole entropy, singularities, and spacetime voids

    SciTech Connect

    Castro, Carlos

    2008-04-15

    We argue why the static spherically symmetric vacuum solutions of Einstein's equations described by the textbook Hilbert metric g{sub {mu}}{sub {nu}}(r) is not diffeomorphic to the metric g{sub {mu}}{sub {nu}}(|r|) corresponding to the gravitational field of a point mass delta function source at r=0. By choosing a judicious radial function R(r)=r+2G|M|{theta}(r) involving the Heaviside step function, one has the correct boundary condition R(r=0)=0, while displacing the horizon from r=2G|M| to a location arbitrarily close to r=0 as one desires, r{sub h}{yields}0, where stringy geometry and quantum gravitational effects begin to take place. We solve the field equations due to a delta function point mass source at r=0, and show that the Euclidean gravitational action (in ({Dirac_h}/2{pi}) units) is precisely equal to the black hole entropy (in Planck area units). This result holds in any dimensions D{>=}3. In the Reissner-Nordstrom (massive charged) and Kerr-Newman black hole case (massive rotating charged) we show that the Euclidean action in a bulk domain bounded by the inner and outer horizons is the same as the black hole entropy. When one smears out the point-mass and point-charge delta function distributions by a Gaussian distribution, the area-entropy relation is modified. We postulate why these modifications should furnish the logarithmic corrections (and higher inverse powers of the area) to the entropy of these smeared black holes. To finalize, we analyze the Bars-Witten stringy black hole in 1+1 dimension and its relation to the maximal acceleration principle in phase spaces and Finsler geometries.

  9. Preservice Mathematics Teachers' Perceptions of Using a Web 2.0 Technology as a Supportive Teaching-Learning Tool in a College Euclidean Geometry Course

    ERIC Educational Resources Information Center

    Hossain, Md. Mokter

    2012-01-01

    This mixed methods study examined preservice secondary mathematics teachers' perceptions of a blogging activity used as a supportive teaching-learning tool in a college Euclidean Geometry course. The effect of a 12-week blogging activity that was a standard component of a college Euclidean Geometry course offered for preservice secondary…

  10. A correlation between decreased parathyroid α-Klotho and fibroblast growth factor receptor 1 expression with pathological category and parathyroid gland volume in dialysis patients.

    PubMed

    Yan, Junfang; Jingbo, Chen; Wang, Deguang; Xie, Shengxue; Yuan, Liang; Zhong, Xing; Hao, Li

    2015-04-01

    The objective of this study was to investigate α-Klotho and fibroblast growth factor receptor 1 (FGFR1) expression in hyperplastic parathyroid glands, as well as their role in the development of renal hyperparathyroidism. Hyperplastic parathyroid glands (n = 90) were obtained from 24 patients who received parathyroidectomy due to secondary renal hyperparathyroidism. Normal parathyroid tissue was obtained from glands (n = 6) that were inadvertently removed, in conjunction with thyroidectomy, from patients with thyroid carcinoma. The expression of α-Klotho and FGFR1 in the parathyroid tissue was detected using immunohistochemical staining. The expression of α-Klotho and FGFR1 was significantly reduced in the hyperplastic parathyroid tissue compared to that in the normal parathyroid tissue. The expression of α-Klotho decreased further with increasing parathyroid pathology. A significant positive correlation was observed between α-Klotho and FGFR1 (r = 0.38, P < 0.01). FGFR1 (r = -0.21, P < 0.05) and α-Klotho (r = -0.42, P < 0.01) were negatively correlated with the volume of the hyperplastic parathyroid tissue. The expression of α-Klotho and FGFR1 decreases in the parathyroid glands of dialysis patients with secondary hyperparathyroidism, and this decrease may play an important role in the pathogenesis of secondary renal hyperparathyroidism.

  11. Vector correlators in lattice QCD: Methods and applications

    NASA Astrophysics Data System (ADS)

    Bernecker, David; Meyer, Harvey B.

    2011-11-01

    We discuss the calculation of the leading hadronic vacuum polarization in lattice QCD. Exploiting the excellent quality of the compiled experimental data for the e + e - → hadrons cross-section, we predict the outcome of large-volume lattice calculations at the physical pion mass, and design computational strategies for the lattice to have an impact on important phenomenological quantities such as the leading hadronic contribution to ( g - 2) μ and the running of the electromagnetic coupling constant. First, the R( s) ratio can be calculated directly on the lattice in the threshold region, and we provide the formulae to do so with twisted boundary conditions. Second, the current correlator projected onto zero spatial momentum, in a Euclidean time interval where it can be calculated accurately, provides a potentially critical test of the experimental R( s) ratio in the region that is most relevant for ( g - 2) μ . This observation can also be turned around: the vector correlator at intermediate distances can be used to determine the lattice spacing in fm, and we make a concrete proposal in this direction. Finally, we quantify the finite-size effects on the current correlator coming from low-energy two-pion states and provide a general parametrization of the vacuum polarization on the torus.

  12. Strain and strain rate by speckle-tracking echocardiography correlate with pressure-volume loop-derived contractility indices in a rat model of athlete's heart.

    PubMed

    Kovács, Attila; Oláh, Attila; Lux, Árpád; Mátyás, Csaba; Németh, Balázs Tamás; Kellermayer, Dalma; Ruppert, Mihály; Török, Marianna; Szabó, Lilla; Meltzer, Anna; Assabiny, Alexandra; Birtalan, Ede; Merkely, Béla; Radovits, Tamás

    2015-04-01

    Contractile function is considered to be precisely measurable only by invasive hemodynamics. We aimed to correlate strain values measured by speckle-tracking echocardiography (STE) with sensitive contractility parameters of pressure-volume (P-V) analysis in a rat model of exercise-induced left ventricular (LV) hypertrophy. LV hypertrophy was induced in rats by swim training and was compared with untrained controls. Echocardiography was performed using a 13-MHz linear transducer to obtain LV long- and short-axis recordings for STE analysis (GE EchoPAC). Global longitudinal (GLS) and circumferential strain (GCS) and longitudinal (LSr) and circumferential systolic strain rate (CSr) were measured. LV P-V analysis was performed using a pressure-conductance microcatheter, and load-independent contractility indices [slope of the end-systolic P-V relationship (ESPVR), preload recruitable stroke work (PRSW), and maximal dP/dt-end-diastolic volume relationship (dP/dtmax-EDV)] were calculated. Trained rats had increased LV mass index (trained vs. control; 2.76 ± 0.07 vs. 2.14 ± 0.05 g/kg, P < 0.001). P-V loop-derived contractility parameters were significantly improved in the trained group (ESPVR: 3.58 ± 0.22 vs. 2.51 ± 0.11 mmHg/μl; PRSW: 131 ± 4 vs. 104 ± 2 mmHg, P < 0.01). Strain and strain rate parameters were also supernormal in trained rats (GLS: -18.8 ± 0.3 vs. -15.8 ± 0.4%; LSr: -5.0 ± 0.2 vs. -4.1 ± 0.1 Hz; GCS: -18.9 ± 0.8 vs. -14.9 ± 0.6%; CSr: -4.9 ± 0.2 vs. -3.8 ± 0.2 Hz, P < 0.01). ESPVR correlated with GLS (r = -0.71) and LSr (r = -0.53) and robustly with GCS (r = -0.83) and CSr (r = -0.75, all P < 0.05). PRSW was strongly related to GLS (r = -0.64) and LSr (r = -0.71, both P < 0.01). STE can be a feasible and useful method for animal experiments. In our rat model, strain and strain rate parameters closely reflected the improvement in intrinsic contractile function induced by exercise training.

  13. Determination of lung segments in computed tomography images using the Euclidean distance to the pulmonary artery

    SciTech Connect

    Stoecker, Christina; Moltz, Jan H.; Lassen, Bianca; Kuhnigk, Jan-Martin; Krass, Stefan; Welter, Stefan; Peitgen, Heinz-Otto

    2013-09-15

    Purpose: Computed tomography (CT) imaging is the modality of choice for lung cancer diagnostics. With the increasing number of lung interventions on sublobar level in recent years, determining and visualizing pulmonary segments in CT images and, in oncological cases, reliable segment-related information about the location of tumors has become increasingly desirable. Computer-assisted identification of lung segments in CT images is subject of this work.Methods: The authors present a new interactive approach for the segmentation of lung segments that uses the Euclidean distance of each point in the lung to the segmental branches of the pulmonary artery. The aim is to analyze the potential of the method. Detailed manual pulmonary artery segmentations are used to achieve the best possible segment approximation results. A detailed description of the method and its evaluation on 11 CT scans from clinical routine are given.Results: An accuracy of 2–3 mm is measured for the segment boundaries computed by the pulmonary artery-based method. On average, maximum deviations of 8 mm are observed. 135 intersegmental pulmonary veins detected in the 11 test CT scans serve as reference data. Furthermore, a comparison of the presented pulmonary artery-based approach to a similar approach that uses the Euclidean distance to the segmental branches of the bronchial tree is presented. It shows a significantly higher accuracy for the pulmonary artery-based approach in lung regions at least 30 mm distal to the lung hilum.Conclusions: A pulmonary artery-based determination of lung segments in CT images is promising. In the tests, the pulmonary artery-based determination has been shown to be superior to the bronchial tree-based determination. The suitability of the segment approximation method for application in the planning of segment resections in clinical practice has already been verified in experimental cases. However, automation of the method accompanied by an evaluation on a larger

  14. Negative correlation between extent of physeal ablation after percutaneous permanent physiodesis and postoperative growth: volume computer tomography and radiostereometric analysis of 37 physes in 27 patients.

    PubMed

    Gunderson, Ragnhild B; Horn, Joachim; Kibsgård, Thomas; Kristiansen, Leif Pål; Pripp, Are Hugo; Steen, Harald

    2013-08-01

    Percutaneous physiodesis in the knee region is a well-established method for treating leg-length inequality. Longitudinal growth in the physis is believed to stop almost immediately after the operation. The extent of physis ablation required has never been investigated by any kind of tomography in humans. Using radiostereometric analysis (RSA), we determined when definite growth arrest occurred after surgery. We also studied the correlation between the extent of physis ablation and postoperative growth. Finally, we assessed any bone bridging across the physis. 6, 12, and 30 weeks after surgery, we used RSA to measure longitudinal growth in 27 patients (37 physes) with a mean age of 13 years. CT scanning of the knee region was performed 12 weeks after surgery to measure the percentage of the ablated physis and to determine the distribution of bone bridges across the physis. RSA showed that growth rate was reduced to less than half of the expected rate after 6 weeks. During the next 6 weeks, the growth ceased completely. CT scans revealed a large variation in the extent of ablated physes (17-69%). In the ablated areas, tissues of various densities were mixed with mature bone. Bridges were found both laterally and medially across the physes in all of the patients. There was a negative correlation between the extent of ablation and total postoperative growth (rho = -0.37, p = 0.03). Growth across the physis is effectively stopped by percutaneous physiodesis. RSA is well-suited for observation of this phenomenon. Volume CT scanning can be used to detect bone bridges that cross the physis and to calculate the extent of physis ablation.

  15. Analysis of ochratoxin A in dried blood spots - Correlation between venous and finger-prick blood, the influence of hematocrit and spotted volume.

    PubMed

    Osteresch, Bernd; Cramer, Benedikt; Humpf, Hans-Ulrich

    2016-05-01

    We report the improvement of a method for the detection of ochratoxin A (OTA) and its thermal degradation product 2'R-ochratoxin A in dried blood spots (DBS) by high performance liquid chromatographic (HPLC) tandem mass spectrometry (MS/MS). The DBS technique was advanced for the analysis of these two compounds in DBS with unknown amounts of blood as well as varying hematocrit values. Furthermore the comparability of venous vs. capillary blood was investigated. Human whole blood samples were spotted, dried, and extracted with a solvent consisting of acetone, acetonitrile and water for analysis by HPLC-MS/MS. Quantification was carried out by stable isotope labelled internal standards. Blood samples of volunteers (n=50) were used to further optimize and simplify the procedure. Ochratoxin A and 2'R-ochratoxin A concentrations found in the entire spots (approx. 100 μL blood) were compared with punched DBS discs of 8.8mm size containing approximately 20 μL blood. As a result the amounts of both toxins in a punched 8.8mm disc correlate well with the entire DBS. Also the use of capillary blood from finger-pricks versus venous blood was evaluated. The analyte levels correlate as well indicating that the less invasive finger-prick sampling gives also reliable results. The influence of hematocrit was investigated in a range of 25-55% according to the hematocrit in the used real blood samples (34-46% hematocrit). However no significant hematocrit effect was observed for the utilized real blood samples. Moreover different blood volumes were spotted and punched as a minimal spot size is usually recommended for accurate analysis. In this experiment finger-prick samples typically consist of about 90 μL blood. Therefore spots of 75, 100 and 125 μL blood were prepared and analyzed. Similar to the hematocrit effect, no considerable influence was observed.

  16. Systematic errors in digital volume correlation due to the self-heating effect of a laboratory x-ray CT scanner

    NASA Astrophysics Data System (ADS)

    Wang, B.; Pan, B.; Tao, R.; Lubineau, G.

    2017-04-01

    The use of digital volume correlation (DVC) in combination with a laboratory x-ray computed tomography (CT) for full-field internal 3D deformation measurement of opaque materials has flourished in recent years. During x-ray tomographic imaging, the heat generated by the x-ray tube changes the imaging geometry of x-ray scanner, and further introduces noticeable errors in DVC measurements. In this work, to provide practical guidance high-accuracy DVC measurement, the errors in displacements and strains measured by DVC due to the self-heating for effect of a commercially available x-ray scanner were experimentally investigated. The errors were characterized by performing simple rescan tests with different scan durations. The results indicate that the maximum strain errors associated with the self-heating of the x-ray scanner exceed 400 µε. Possible approaches for minimizing or correcting these displacement and strain errors are discussed. Finally, a series of translation and uniaxial compression tests were performed, in which strain errors were detected and then removed using pre-established artificial dilatational strain-time curve. Experimental results demonstrate the efficacy and accuracy of the proposed strain error correction approach.

  17. 3D mechanical analysis of aeronautical plain bearings: Validation of a finite element model from measurement of displacement fields by digital volume correlation and optical scanning tomography

    NASA Astrophysics Data System (ADS)

    Germaneau, A.; Peyruseigt, F.; Mistou, S.; Doumalin, P.; Dupré, J.-C.

    2010-06-01

    On Airbus aircraft, spherical plain bearings are used on many components; in particular to link engine to pylon or pylon to wing. Design of bearings is based on contact pressure distribution on spherical surfaces. To determine this distribution, a 3D analysis of the mechanical behaviour of aeronautical plain bearing is presented in this paper. A numerical model has been built and validated from a comparison with 3D experimental measurements of kinematic components. For that, digital volume correlation (DVC) coupled with optical scanning tomography (OST) is employed to study the mechanical response of a plain bearing model made in epoxy resin. Experimental results have been compared with the ones obtained from the simulated model. This comparison enables us to study the influence of various boundary conditions to build the FE model. Some factors have been highlighted like the fitting behaviour which can radically change contact pressure distribution. This work shows the contribution of a representative mechanical environment to study precisely mechanical response of aeronautical plain bearings.

  18. Inverse correlation between expression of the Wolfs Hirschhorn candidate gene Letm1 and mitochondrial volume in C. elegans and in mammalian cells.

    PubMed

    Hasegawa, Ayako; van der Bliek, Alexander M

    2007-09-01

    Deletion of the Letm1 gene correlates with the occurrence of epilepsy in patients with Wolf-Hirschhorn syndrome. The Letm1 gene encodes a mitochondrial protein that is homologous to yeast Mdm38. Yeast Mdm38 is localized to the mitochondrial inner membrane where it was proposed to act as a K+/H+ antiporter or alternatively as a chaperone for selected mitochondrial inner membrane proteins. Here, we present cellular and biochemical analysis of Letm1 in mammalian cells and an analysis of a C. elegans mutant that could serve as a model for Wolf-Hirschhorn syndrome. We localized the Letm1 protein to the mitochondrial inner membrane of mammalian cells, where it exists in a 550-kDa complex. We show that Letm1 can bind to itself in vitro, raising the possibility that it can form higher order multimers in vivo. Reduced levels of Letm1 in human cells and in C. elegans lead to swellings along the lengths of mitochondria, consistent with the phenotype observed in yeast. Electron micrographs show mitochondria with swollen matrices that are less electron-dense than matrices in normal mitochondria. The opposite effect is achieved by overexpression of Letm1. Overexpression increases the electron density of the mitochondrial matrix and swelling of cristae. Our results are therefore consistent with a protein that regulates the volume of the mitochondrial matrix.

  19. Aqueous Levels of Angiopoietin-like 4 and Semaphorin 3E Correlate with Nonperfusion Area and Macular Volume in Diabetic Retinopathy.

    PubMed

    Kwon, Soo Hyun; Shin, Jae Pil; Kim, In Taek; Park, Dong Ho

    2015-05-01

    To investigate the aqueous levels of angiopoietin-like 4 (ANGPTL4), semaphorin 3E (Sema3E), and vascular endothelial growth factor (VEGF) in patients with diabetic retinopathy and to ascertain their association with diabetic retinopathy phenotypes. Prospective, nonrandomized, comparative case series. Of all 104 consecutive patients (104 eyes) who had intravitreal anti-VEGF injections from April 2012 through April 2013 for diabetic macular edema (DME), 51 had severe nonproliferative diabetic retinopathy (NPDR) and 53 had proliferative diabetic retinopathy (PDR). The controls were 54 consecutive nondiabetic patients who had undergone cataract surgery (54 eyes) during the same period. The ANGPTL4, Sema3E, and VEGF levels in aqueous humor samples obtained before intravitreal injections were measured by enzyme-linked immunosorbent assay. Capillary nonperfusion area (NPA) was calculated from encircled angiography using the 7 standard field images described in the Early Treatment Diabetic Retinopathy Study protocol. Total macular volume (TMV) was measured by spectral-domain optical coherence tomography. Aqueous ANGPTL4, Sema3E, and VEGF levels in severe NPDR, PDR, and control groups and their correlations with each other, NPA, and TMV. The severe NPDR and PDR groups had higher aqueous levels of ANGPTL4 and VEGF than the control group (all P < 0.001). The PDR group had higher ANGPTL4 and VEGF levels than the severe NPDR group (both P < 0.001). The aqueous ANGPTL4 levels of all diabetic retinopathy patients correlated positively with NPA (r = 0.820, P = 0.003) and TMV (r = 0.824, P < 0.001). The control group had higher aqueous Sema3E levels than the NPDR and PDR groups (both P < 0.001). Aqueous Sema3E levels correlated negatively with VEGF levels in all subjects (r = -0.57, P = 0.025). The ANGPTL4 may be a candidate target in DME treatment and a biomarker of ischemic-induced retinopathy, including diabetic retinopathy. Copyright © 2015 American Academy of Ophthalmology

  20. The apparent diffusion coefficient is strongly correlated with extracellular volume, a measure of myocardial fibrosis, and subclinical cardiomyopathy in patients with systemic lupus erythematosus.

    PubMed

    Wu, Rui; An, Dong-Aolei; Hu, Jiani; Jiang, Meng; Guo, Qiang; Xu, Jian-Rong; Wu, Lian-Ming

    2017-01-01

    Background Extracellular volume (ECV) has been histologically validated as a non-invasive quantitative index of myocardial fibrosis that does not require the use of contrast, which is contraindicated in patients with renal insufficiency. Purpose To evaluate the correlation between the contrast-free apparent diffusion coefficient (ADC) and ECV, an index of fibrosis. Material and Methods Twenty-four patients with systemic lupus erythematosus (SLE), who were predominantly women (mean age = 36 ± 12 years) and 12 normal participants (mean age = 38 ± 10 years) underwent cardiac magnetic resonance (CMR) via 3.0 T MR with T1 mapping. Diffusion-weighted imaging (DWI) and late gadolinium-enhanced (LGE) imaging served as the reference standards with which CMR was compared. The mean ADC, native T1, and ECV were calculated for each patient, and the correlations among these parameters were analyzed. Results Both SLE LGE-positive (LGE+) and SLE LGE-negative (LGE-) participants had higher native T1 values, ECV, and ADC than normal controls ( P < 0.05). SLE LGE+ participants exhibited a higher ECV (0.31 ± 0.02) and ADC (2.44 ± 0.32 × 10(-3 )mm(2)/s) than SLE LGE- participants ( p < 0.05); however, SLE LGE+ and SLE LGE- participants had similar native T1 values (1227 ± 48.81 ms versus 1174.70 ± 95.80 ms, respectively; P > 0.05). ADC values were positively correlated with increased ECV (R(2 )= 0.62) and native T1 values (R(2 )= 0.28) in all participants. Conclusion ADC measurements are a suitable alternative to ECV that may be used to assess and quantify myocardial fibrosis in patients with SLE.

  1. Correlation of IVC Diameter and Collapsibility Index With Central Venous Pressure in the Assessment of Intravascular Volume in Critically Ill Patients

    PubMed Central

    Ilyas, Abid; Ishtiaq, Wasib; Assad, Salman; Mansoor, Salman; Haris, Muhammad; Qadeer, Aayesha; Akhtar, Aftab

    2017-01-01

    Objective The objective of our study is to assess the correlation between inferior vena cava (IVC) diameters, central venous pressure (CVP) and the IVC collapsibility index for estimating the volume status in critically ill patients. Methods This cross-sectional study used the convenient sampling of 100 adult medical intensive care unit (ICU) patients for a period of three months. Patients ≥ 18 years of age with an intrathoracic central venous catheter terminating in the distal superior vena cava connected to the transducer to produce a CVP waveform were included in the study. A Mindray diagnostic ultrasound system model Z6 ultrasound machine (Mindray, NJ, USA) was used for all examinations. An Ultrasonic Transducer model 3C5P (Mindray, NJ, USA) for IVC imaging was utilized. A paired sampled t-test was used to compute the p-values. Results A total of 32/100 (32%) females and 68/100 (68%) males were included in the study with a mean age of 50.4 ± 19.3 years. The mean central venous pressure maintained was 10.38 ± 4.14 cmH2O with an inferior vena cava collapsibility index of 30.68 ± 10.93. There was a statistically significant relation among the mean CVP pressure, the IVC collapsibility index, the mean maximum and minimum IVC between groups as determined by one-way analysis of variance (ANOVA) (p < 0.001). There was a strong negative correlation between CVP and IVC collapsibility index (%), which was statistically significant (r = -0.827, n = 100, p < 0.0005). A strong positive correlation between CVP and maximum IVC diameter (r = 0.371, n = 100, p < 0.0005) and minimum IVC diameter (r = 0.572, n = 100, p < 0.0005) was found. Conclusion There is a positive relationship of CVP with minimum and maximum IVC diameters but an inverse relationship with the IVC collapsibility index. PMID:28348943

  2. Topological charge correlators, spectral bounds, and contact terms

    SciTech Connect

    F.X. Lee; S.J. Dong; T. Draper; I. Horvath; K.F. Liu; H. Thacker; J.B. Zhang

    2003-05-01

    The structure of topological charge fluctuations in the QCD vacuum is strongly restricted by the spectral negativity of the Euclidean correlator for x = 0 and the presence of a positive contact term. Some examples are considered which illustrate the physical origin of these properties.

  3. Hierarchical clustering using correlation metric and spatial continuity constraint

    DOEpatents

    Stork, Christopher L.; Brewer, Luke N.

    2012-10-02

    Large data sets are analyzed by hierarchical clustering using correlation as a similarity measure. This provides results that are superior to those obtained using a Euclidean distance similarity measure. A spatial continuity constraint may be applied in hierarchical clustering analysis of images.

  4. Dental arch asymmetry in young healthy human subjects evaluated by Euclidean distance matrix analysis.

    PubMed

    Ferrario, V F; Sforza, C; Miani, A; Serrao, G

    1993-03-01

    Form differences between biological structures can be evaluated using several approaches. A recently proposed method (Euclidean distance matrix analysis; EDMA) seems to be able to differentiate between size and shape differences. Here it has been applied to study the asymmetry of mandibular and maxillary arches in 50 men and 45 women with sound dentitions. The centres of gravity (centroids) of the occlusal surfaces of all permanent teeth (right second molar to left second molar) were individualized on the dental casts of subjects. The form of the right and left maxillary and mandibular hemi-arches was separately assessed by calculating all the possible linear distances between pairs of teeth within arch and side. Side differences were tested by EDMA. In men, the maxillary and the mandibular arches were both symmetrical (i.e. there were no significant differences in size or shape between the left and right hemi-arches). In women, the mandibular arch was symmetrical, but in the maxillary arch the two antimeres had a significantly different shape. No size differences were found between the left and right female hemi-arches.

  5. Failure mode and effects analysis using intuitionistic fuzzy hybrid weighted Euclidean distance operator

    NASA Astrophysics Data System (ADS)

    Liu, Hu-Chen; Liu, Long; Li, Ping

    2014-10-01

    Failure mode and effects analysis (FMEA) has shown its effectiveness in examining potential failures in products, process, designs or services and has been extensively used for safety and reliability analysis in a wide range of industries. However, its approach to prioritise failure modes through a crisp risk priority number (RPN) has been criticised as having several shortcomings. The aim of this paper is to develop an efficient and comprehensive risk assessment methodology using intuitionistic fuzzy hybrid weighted Euclidean distance (IFHWED) operator to overcome the limitations and improve the effectiveness of the traditional FMEA. The diversified and uncertain assessments given by FMEA team members are treated as linguistic terms expressed in intuitionistic fuzzy numbers (IFNs). Intuitionistic fuzzy weighted averaging (IFWA) operator is used to aggregate the FMEA team members' individual assessments into a group assessment. IFHWED operator is applied thereafter to the prioritisation and selection of failure modes. Particularly, both subjective and objective weights of risk factors are considered during the risk evaluation process. A numerical example for risk assessment is given to illustrate the proposed method finally.

  6. Stratification approach for 3-D euclidean reconstruction of nonrigid objects from uncalibrated image sequences.

    PubMed

    Wang, Guanghui; Wu, Q M Jonathan

    2008-02-01

    This paper addresses the problem of 3-D reconstruction of nonrigid objects from uncalibrated image sequences. Under the assumption of affine camera and that the nonrigid object is composed of a rigid part and a deformation part, we propose a stratification approach to recover the structure of nonrigid objects by first reconstructing the structure in affine space and then upgrading it to the Euclidean space. The novelty and main features of the method lies in several aspects. First, we propose a deformation weight constraint to the problem and prove the invariability between the recovered structure and shape bases under this constraint. The constraint was not observed by previous studies. Second, we propose a constrained power factorization algorithm to recover the deformation structure in affine space. The algorithm overcomes some limitations of a previous singular-value-decomposition-based method. It can even work with missing data in the tracking matrix. Third, we propose to separate the rigid features from the deformation ones in 3-D affine space, which makes the detection more accurate and robust. The stratification matrix is estimated from the rigid features, which may relax the influence of large tracking errors in the deformation part. Extensive experiments on synthetic data and real sequences validate the proposed method and show improvements over existing solutions.

  7. A weighted Euclidean distance method for rural settlements traffic location evaluation

    NASA Astrophysics Data System (ADS)

    Wang, Tongkun; Chen, Zhenjie; Chen, Dong; Jia, Mingchao

    2007-06-01

    Traffic location is one of the most important factors which affect the development of rural settlements. However, there is no effective method to evaluation traffic location of rural settlements at present. Focusing on large numbers of scattered rural settlements with complicated and fragmentized traffic networks, a weighted euclidean distance method for rural settlements traffic location evaluation is put forward in this paper. In order to differentiate the affection that different levels of roads put on rural settlements, roads are sorted into two classes: the level-roads (such as national and provincial roads, county and town roads) and the village-roads. Then the total quantized value of traffic location of rural settlements, obtained by weighing traffic location quantized values on different road levels, was calculated by GIS spatial analysis module. This method was put into practice to analyze the traffic location of Tonglu County, Zhejiang Province, which showed that it has obtained a fairly good result on the evaluation of the traffic location of rural settlements.

  8. A new wide range Euclidean distance circuit for neural network hardware implementations.

    PubMed

    Gopalan, A; Titus, A H

    2003-01-01

    In this paper, we describe an analog very large-scale integration (VLSI) implementation of a wide range Euclidean distance computation circuit - the key element of many synapse circuits. This circuit is essentially a wide-range absolute value circuit that is designed to be as small as possible (80 /spl times/ 76 /spl mu/m) in order to achieve maximum synapse density while maintaining a wide range of operation (0.5 to 4.5 V) and low power consumption (less than 200 /spl mu/W). The circuit has been fabricated in 1.5-/spl mu/m technology through MOSIS. We present simulated and experimental results of the circuit, and compare these results. Ultimately, this circuit is intended for use as part of a high-density hardware implementation of a self-organizing map (SOM). We describe how this circuit can be used as part of the SOM and how the SOM is going to be used as part of a larger bio-inspired vision system based on the octopus visual system.

  9. Non-Abelian Ball-Chiu vertex for arbitrary Euclidean momenta

    NASA Astrophysics Data System (ADS)

    Aguilar, A. C.; Cardona, J. C.; Ferreira, M. N.; Papavassiliou, J.

    2017-07-01

    We determine the non-Abelian version of the four nontransverse form factors of the quark-gluon vertex, using exact expressions derived from the Slavnov-Taylor identity that this vertex satisfies. In addition to the quark and ghost propagators, a key ingredient of the present approach is the quark-ghost scattering kernel, which is computed within the one-loop dressed approximation. The vertex form factors obtained from this procedure are evaluated for arbitrary Euclidean momenta, and display features not captured by the well-known Ball-Chiu vertex, deduced from the Abelian (ghost-free) Ward identity. Particularly interesting in this analysis is the so-called soft-gluon limit, which, unlike other kinematic configurations considered, is especially sensitive to the approximations employed for the vertex entering in the quark-ghost scattering kernel, and may even be affected by a subtle numerical instability. As an elementary application of the results obtained, we evaluate and compare certain renormalization-point-independent combinations, which contribute to the interaction kernels appearing in the standard quark gap and Bethe-Salpeter equations. In doing so, even though all form factors of the quark-gluon vertex, and in particular the transverse ones which are unconstrained by our procedure, enter nontrivially in the aforementioned kernels, only the contribution of a single form factor, corresponding to the classical (tree-level) tensor, will be considered.

  10. Projectivity, affine, similarity and euclidean coordinates transformation parameters from ITRF to EUREF in Turkey

    NASA Astrophysics Data System (ADS)

    Ansari, Kutubuddin; Corumluoglu, Ozsen; Yetkin, Mevlut

    2017-03-01

    Today, in geodesy most practical applications is to use a datum to get three dimensional position of a particular point. The geodetic techniques generally provide time dependent coordinates in global datum. The difference between the global datum like international terrestrial reference frame (ITRF) to local datum like Europe fixed reference frame (EUREF) can be up to several centimeters due to different velocity rate of tectonic plates. To get high-precision measurements, there is an increasing need of time dependent transformations from the global level to local level. The present paper treats, this theoretical problem of geodesy by using mathematical dependency between two spatial coordinate systems whose common points are given in both systems. The paper describes four different (projective, affine, similarity and euclidean) modified methodologies for the transformation between global (ITRF) to local (EUREF) by using the Turkish permanent GPS network (TPGN) as an example. The time series from TPGN stations are used to review these transformations from ITRF 2008 to EUREF 2008. The transformation parameters in all cases shows that mostly transform coordinates depends on its counterparts (X to x and Y to y) and others coordinates have very less effect. Finally to show the validity of our model a comparative analysis with standard Bursa-Wolf and Molodensky-Badekas models has been presented. The test shows that our model error is equivalent to standard models, in this view the presented models are acceptable and can improve our understanding in coordinate transformation.

  11. Confidence Analysis of Standard Deviational Ellipse and Its Extension into Higher Dimensional Euclidean Space

    PubMed Central

    Wang, Bin; Shi, Wenzhong; Miao, Zelang

    2015-01-01

    Standard deviational ellipse (SDE) has long served as a versatile GIS tool for delineating the geographic distribution of concerned features. This paper firstly summarizes two existing models of calculating SDE, and then proposes a novel approach to constructing the same SDE based on spectral decomposition of the sample covariance, by which the SDE concept is naturally generalized into higher dimensional Euclidean space, named standard deviational hyper-ellipsoid (SDHE). Then, rigorous recursion formulas are derived for calculating the confidence levels of scaled SDHE with arbitrary magnification ratios in any dimensional space. Besides, an inexact-newton method based iterative algorithm is also proposed for solving the corresponding magnification ratio of a scaled SDHE when the confidence probability and space dimensionality are pre-specified. These results provide an efficient manner to supersede the traditional table lookup of tabulated chi-square distribution. Finally, synthetic data is employed to generate the 1-3 multiple SDEs and SDHEs. And exploratory analysis by means of SDEs and SDHEs are also conducted for measuring the spread concentrations of Hong Kong’s H1N1 in 2009. PMID:25769048

  12. Quantitative analysis of Euclidean distance to complement qualitative analysis of facial expression during deception

    PubMed Central

    Mondal, Ananya; Mukhopadhyay, Pritha; Basu, Nabanita; Bandyopadhyay, Samir Kumar; Chatterjee, Tanima

    2016-01-01

    Background: Accurate evaluation of an individuals' veracity is a fundamental aspect of social functioning that allows individuals to act in adaptive ways. The domain of deception detection ability is still young, and many components in this field are yet to be touched which demands more research in this field. Aims: The present study aims at deciphering the structural composition of face during felt, posed, and deceived emotions in facial expression unique to Indian culture, using Facial Action Coding System (FACS). Quantitative analysis of Euclidean distance has been done to complement qualitative FACS analysis. Methods: In this study, thirty female, young adults with age range of 23–27 years were chosen randomly for portraying their (felt, posed, and deceived) facial expression. All facial expressions were captured through instruction, and videos were converted into static images. The static images were coded on the basis of FACS to decipher the felt, posed, and deceived expressions. Quantitative analysis of the data has been done using MATLAB to meet the objectives of the study and to complement the qualitative analysis. Results: Felt and posed emotions differ in terms of intensity of the expression and subjective experience. Posed emotional and deceived expressions differ in intent. Facial asymmetry is an important indicator for detecting deception. PMID:28163412

  13. Efficient convex-elastic net algorithm to solve the Euclidean traveling salesman problem.

    PubMed

    Al-Mulhem, M; Al-Maghrabi, T

    1998-01-01

    This paper describes a hybrid algorithm that combines an adaptive-type neural network algorithm and a nondeterministic iterative algorithm to solve the Euclidean traveling salesman problem (E-TSP). It begins with a brief introduction to the TSP and the E-TSP. Then, it presents the proposed algorithm with its two major components: the convex-elastic net (CEN) algorithm and the nondeterministic iterative improvement (NII) algorithm. These two algorithms are combined into the efficient convex-elastic net (ECEN) algorithm. The CEN algorithm integrates the convex-hull property and elastic net algorithm to generate an initial tour for the E-TSP. The NII algorithm uses two rearrangement operators to improve the initial tour given by the CEN algorithm. The paper presents simulation results for two instances of E-TSP: randomly generated tours and tours for well-known problems in the literature. Experimental results are given to show that the proposed algorithm ran find the nearly optimal solution for the E-TSP that outperform many similar algorithms reported in the literature. The paper concludes with the advantages of the new algorithm and possible extensions.

  14. a Euclidean Formulation of Interior Orientation Costraints Imposed by the Fundamental Matrix

    NASA Astrophysics Data System (ADS)

    Kalisperakis, I.; Karras, G.; Petsa, E.

    2016-06-01

    Epipolar geometry of a stereopair can be expressed either in 3D, as the relative orientation (i.e. translation and rotation) of two bundles of optical rays in case of calibrated cameras or, in case of unclalibrated cameras, in 2D as the position of the epipoles on the image planes and a projective transformation that maps points in one image to corresponding epipolar lines on the other. The typical coplanarity equation describes the first case; the Fundamental matrix describes the second. It has also been proven in the Computer Vision literature that 2D epipolar geometry imposes two independent constraints on the parameters of camera interior orientation. In this contribution these constraints are expressed directly in 3D Euclidean space by imposing the equality of the dihedral angle of epipolar planes defined by the optical axes of the two cameras or by suitably chosen corresponding epipolar lines. By means of these constraints, new closed form algorithms are proposed for the estimation of a variable or common camera constant value given the fundamental matrix and the principal point position of a stereopair.

  15. a Robust Method for Stereo Visual Odometry Based on Multiple Euclidean Distance Constraint and Ransac Algorithm

    NASA Astrophysics Data System (ADS)

    Zhou, Q.; Tong, X.; Liu, S.; Lu, X.; Liu, S.; Chen, P.; Jin, Y.; Xie, H.

    2017-07-01

    Visual Odometry (VO) is a critical component for planetary robot navigation and safety. It estimates the ego-motion using stereo images frame by frame. Feature points extr