Sample records for eunice kennedy shriver
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-21
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(a) of the... Children's Study, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-22
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(a) of the... Study, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-09
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(a) of the..., Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-16
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(a) of the... Children's Study, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-20
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(a) of the... Children's Study, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-10-21
... National Institute of Child Health and Human Development Notice of Meeting Pursuant to section 10(d) of the... Eunice Kennedy Shriver National Institute of Child Health & Human Development, including consideration of... Director, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 9000...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-23
... National Institute of Child Health and Human Development; Notice of Meeting Pursuant to section 10(d) of... conducted by the Eunice Kennedy Shriver National Institute of Child Health & Human Development, including..., Scientific Director, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-25
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Meeting Pursuant to section 10(a) of..., Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-23
... National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(d) of the... Eunice Kennedy Shriver National Institute of Child Health & Human Development, including consideration of... Kennedy Shriver National Institute of Child Health and Human Development, NIH, 9000 Rockville Pike...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-01
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as [[Page 12600
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-07
.... Individuals planning to attend the teleconference may do so by calling the toll-free number, 866-692-3158 and...., Biological Sciences and Career Development, NCMRR, Eunice Kennedy Shriver National Institute of Child Health...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-09
... Institute of Child Health and Human Development; Special Emphasis Panel; Infertility Treatment, Child Growth... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-11-01
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Environmental and Biological...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-22
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel, ``RECOVERY'' The National Standard...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-03
... Committee: National Institute of Child Health and Human Development Special Emphasis Panel, Spinal Circuits... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-14
... Committee: National Institute of Child Health and Human Development Initial Review Group; Reproduction... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-05-30
... Institute of Child Health and Human Development Initial Review Group; Reproduction, Andrology, and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meetings Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-08
... Institute of Child Health and Human Development Initial Review Group; Reproduction, Andrology, and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-13
... Institute of Child Health and Human Development Initial Review Group; Reproduction, Andrology, and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-27
... Institute of Child Health and Human Development Initial Review Group, Reproduction, Andrology, and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-26
... Institute of Child Health and Human Development Initial Review Group, Reproduction, Andrology, and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-23
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Donald Compton: Connections Among...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-12
... Institute of Child Health and Human Development Special Emphasis Panel; Learning Disabilities Innovation... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-19
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development; Special Emphasis Panel. Folic Acid Supplementation and...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-04-12
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Folic Acid/Zinc Sulfate...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-19
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group; Health, Behavior, and Context... Health, Eunice Kennedy Shriver, National Institute For Child Health & Development, 6100 Executive...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-01
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group, Developmental Biology Subcommittee... Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-12
... Institute of Child Health and Human Development Special Emphasis Panel; Optimizing Social Communication in... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-27
... Institute of Child Health and Human Development Initial Review Group, Health, Behavior, and Context... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-11
... Institute of Child Health and Human Development Initial Review Group, Health, Behavior, and Context... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-12
... Institute of Child Health and Human Development Initial Review Group; Health, Behavior, and Context... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-13
... Institute of Child Health and Human Development Initial Review Group; Health, Behavior, and Context... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-16
... Institute of Child Health and Human Development Initial Review Group; Health, Behavior, and Context... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-05-19
... Institute of Child Health and Human Development Initial Review Group, Health, Behavior, and Context... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-15
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; First and Second Trimester...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-09
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group Function, Integration, and... Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-11-01
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...: National Institute of Child Health and Human Development Special Emphasis Panel; Neonatal Research Network...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-09
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Population Educational Training... Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-28
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel, Social-Cognitive Skill Intervention...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-14
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Risk Genes and Environment...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-21
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development; Special Emphasis Panel; Ob/Gyn Postdoctoral Training...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-11-20
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Committee: National Institute of Child Health and Human Development Special Emphasis Panel; Contraceptive...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-06
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Genomic Sequencing and Newborn...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-13
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Reproductive Scientist Development...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-02
... Institute of Child Health and Human Development Special Emphasis Panel Autism and Related Disorders Date... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-02
... Institute of Child Health and Human Development Special Emphasis Panel, Autism Centers of Excellence... National Institute of Child Health & Human Development; Notice of Closed Meetings Pursuant to section 10(d..., OD, Eunice Kennedy Shriver National Institute of Child Health And Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-09
... Institute of Child Health and Human Development Special Emphasis Panel, HIV Reproduction. Date: December 1... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meetings Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-20
... Institute of Child Health and Human Development Special Emphasis Panel, The Development of Infant Behavioral... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Officer, Division of Scientific Review, Eunice Kennedy Shriver National Institute of Child Health and...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-21
... National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(a) of the..., Eunice Kennedy Shriver, National Institute of Child Health & Human Development, NIH, DHHS, 6100 Executive... Initiatives. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-11
... National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(a) of the..., Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, 6100... presentation and various reports on Medical Research Initiatives. Place: Hilton Washington/Rockville 1750...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-12
... Institute of Child Health and Human Development Special Emphasis Panel; Natural History. Date: November 2... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-15
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Congenital Diaphragmatic Hernia..., Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-14
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel, National Children's Study-- Vanguard... Officer, Division of Scientific Review, Eunice Kennedy Shriver National Institute of Child Health and...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-01
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development, Special Emphasis Panel. Alpha-Endosulfine in Mamalian..., Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-02-19
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the National Institute of Child Health and Human Development Special...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-04
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Corpus Luteal Contribution to...., Scientific Review Officer, Division of Scientific Review, Eunice Kennedy Shriver National Institute of Child...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-10-05
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development, Special Emphasis Panel, Neuroplasticity and the Maternal... Scientific Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-04
... Institute of Child Health and Human Development Special Emphasis Panel; Race-Based Social Stress and Health... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-09
...: National Institute of Child Health and Human Development Special Emphasis Panel, Brain and Behavior. Date... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-10
... National Institute of Child Health & Human Development Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Topics in Development, Signaling... Review, OD, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-02
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Nature and Acquisition of Speech... Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-15
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Human Capital Interventions Across... Scientific Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-09
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group; Developmental Biology Subcommittee..., Eunice Kennedy Shriver National Institute of Child Health And Human Development, NIH, 6100 Executive Blvd...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-15
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Committee: National Institute of Child Health and Human Development Special Emphasis Panel; Rett Syndrome... Scientific Review, Eunice Kennedy Shriver National Institute of Child Health And Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-11
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group, Obstetrics and Maternal-Fetal Biology... of Scientific Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-11
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel, Children's Research, Institute For... Scientific Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-11
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel, Child Health Research Career..., Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-14
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group, Health, Behavior, and Context..., Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-11
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...: National Institute of Child Health and Human Development Special Emphasis Group, Asymmetric Robotic Gait... Scientific Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-09
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...: National Institute of Child Health and Human Development Special Emphasis Panel; Maternofetal Signaling and... Scientific Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-02
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... of Committee: National Institute of Child Health and Human Development Special Emphasis Panel, ZHD1... of Scientific Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-01
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel, Molecular and Cellular Controls of... Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-12-07
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel. NICHD T32 Teleconference Review... of Scientific Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-02-03
... Institute of Child Health and Human Development, Special Emphasis Panel, Maternal Fetal Medicine Units... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-04
... Institute of Child Health and Human Development Special Emphasis Panel, The Role of Human-Animal Interaction... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-24
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development, Special Emphasis Panel. The Role of Human-Animal...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-14
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(a) of the... National Advisory Child Health and Human Development Council. The meeting will be open to the public, with...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-10
... National Institute of Child Health & Human Development Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group; Pediatrics Subcommittee Date: June 14..., Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-02
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; ZHD1 RRG-K 52 1, Rehabilitation...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-05-10
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel Congenital Defects Topics. Date: May..., Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-17
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(a) of the... National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room 5C01, Bethesda...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-01-07
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(a) of the... National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room 5C01, Bethesda...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-01
... Institute of Child Health and Human Development Initial Review Group; Reproduction, Andrology, and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-11-08
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Prospective Analysis of...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-21
... National Institute of Child Health and Human Development; Notice of Meeting Pursuant to section 10(a) of..., Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of... presentation, NCMRR Director's Report presentation and various reports on Medical Research Initiatives. Place...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-09-12
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Meeting Pursuant to section 10(d) of... Committee: National Institute of Child Health and Human Development Special Emphasis Panel; Further...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-28
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel, ZHD1 DRG (RL). Date: April 12, 2013..., Eunice Kennedy Shriver National Institute of Child Health And Human Development, NIH, 6100 Executive Blvd...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-03-31
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Meeting Pursuant to section 10(a) of the... Child Health and Human Development, NIH, 6100 Executive Blvd., Room 3A01, Bethesda, MD 20892, (301) 451...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-21
... Institute of Child Health and Human Development Special Emphasis Panel; ZHD1 DSR-H (NJ) Date: April 8, 2013... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-10-17
... Institute of Child Health and Human Development, Special Emphasis Panel. ZHD1 DRG-H 40 1. Date: November 3... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-26
... Institute of Child Health and Human Development Special Emphasis Panel; ZHD1 DSR-H 54 1. Date: May 7, 2012... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-28
... Institute of Child Health and Human Development Special Emphasis Panel, ZHD1 DSR-H 40 1. Date: December 7... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-25
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel--Assays of Biological Specimens in...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-01
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; Neuroscience Blueprint: Tools for...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-11-14
... National Institute of Child Health and Human Development; Notice of Meeting Pursuant to section 10(a) of..., Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, 6100... Business Innovative Research (SBIR) Initiatives Place: Hyatt Regency Bethesda Hotel, One Bethesda Metro...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-21
... Institute of Child Health and Human Development Initial Review Group Health, Behavior, and Context... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-12-16
...: National Institute of Child Health and Human Development Initial Review Group; Health, Behavior, and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-03
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group; Obstetrics and Maternal-Fetal Biology...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-07
... National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel, Child Health Research Career... of Scientific Review, Eunice Kennedy Shriver National Institute of Child Health and Human Development...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-04-17
... National Institute of Child Health and Human Development; Notice of Meeting Pursuant to section 10(a) of..., such as sign language interpretation or other reasonable accommodations, should notify the Contact... Sciences and Career Development, NCMRR, Eunice Kennedy Shriver National Institute of Child Health and Human...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-07
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel, Risk Genes and Environmental...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-07-23
... Chemical Synthesis Facility. Date: July 26, 2012. Time: 1:00 p.m. to 3:30 p.m. Agenda: To review and... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-14
... National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; CBPR and Health Disparities. Date... Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-07-29
... Institute of Child Health and Human Development, Special Emphasis Panel, ZHD1 DSR-H 51. Date: August 3, 2011... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-11-25
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-01
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be closed to...
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Signore, Caroline; Freeman, Roger K; Spong, Catherine Y
2009-03-01
In August 2007, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institutes of Health Office of Rare Diseases, the American College of Obstetricians and Gynecologists, and the American Academy of Pediatrics cosponsored a 2-day workshop to reassess the body of evidence supporting antepartum assessment of fetal well-being, identify key gaps in the evidence, and formulate recommendations for further research. Participants included experts in obstetrics and fetal physiology and representatives from relevant stakeholder groups and organizations. This article is a summary of the discussions at the workshop, including synopses of oral presentations on the epidemiology of stillbirth and fetal neurological injury, fetal physiology, techniques for antenatal monitoring, and maternal and fetal indications for monitoring. Finally, a synthesis of recommendations for further research compiled from three breakout workgroups is presented.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-21
... Person: Peter Zelazowski, Ph.D., Scientific Review Officer, Division of Scientific Review, Eunice Kennedy..., Bethesda, MD 20892, 301-435-6902, peter[email protected] . (Catalogue of Federal Domestic Assistance...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-10-25
... Person: Peter Zelazowski, PhD, Scientific Review Officer, Division of Scientific Review, Eunice Kennedy... 5B01, Bethesda, MD 20892-7510, 301-435- 6902, peter[email protected] . (Catalogue of Federal Domestic...
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Giacoia, George P; Taylor-Zapata, Perdita; Zajicek, Anne
2012-11-01
The Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health (NIH) organized a workshop held in November 2011 to address knowledge gaps that limit the availability of adequate pediatric formulations. This workshop was used as a means to identify the types of research innovations needed and to stimulate research efforts designed to improve the availability of pediatric formulations and the technologies required to make these formulations. Information for this article was gathered from the proceedings of the Second US PFI Workshop sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development in Bethesda, Maryland, on November 1 and 2, 2011, as well as from post-workshop discussions. The workshop preparation began with formation of 4 working groups: Biopharmaceutics, Biopharmaceutics Classification System (BCS), New Technology and Drug Delivery Systems, and Taste and Flavor. The recommendations of the 4 working groups will form the basis for the development of a blueprint to guide future research efforts. The pediatric-specific problems identified include the heterogeneity of the population, the small size of the pediatric drug market, the limited number of new formulations for the large number of off-patent and unlabeled drugs, and the lack of universal agreement on how to define appropriate formulations for different ages and stages of development. There was consensus on the need to develop a universal technology platform for flexible pediatric dosage forms, transforming an empirical process into a science-based platform. A number of problems affect the availability of drugs in the developing world. Age-appropriate solid oral pediatric medicines for common diseases can have a global impact. Success on a global scale depends on the commitment of policy makers, regulators, scientists, pharmaceutical companies, sponsors, government, and research foundations to address gaps in
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-03
... Institute of Child Health and Human Development Special Emphasis Panel, Cognitive Development. Date... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-06
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel, Academic-Community Partnership... Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-01
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Health and Human Development Initial Review Group; Health, Behavior, and Context Subcommittee. Date... Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-02-25
... National Institute of Child Health & Human Development Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group; Pediatrics Subcommittee. Date: March... Kennedy Shriver National Institute of, Child Health and Human Development, NIH, 6100 Executive Blvd., Room...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-09
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group; Pediatrics Subcommittee. Date: October... Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-24
... Institute of Child Health and Human Development Special Emphasis Group; Rehabilitation Medicine Scientist... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-08
... Institute of Child Health and Human Development Special Emphasis Panel; Autism Center of Excellence: Network... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 executive blvd., Room...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-09
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special, Emphasis Panel, Global Health. Date: October 29... Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-01
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d...: National Institute of Child Health and Human Development Special Emphasis Panel; Safety and efficacy of... Kennedy Shriver National Institute of Child Health and Human Development, NIH 6100 Executive Blvd., Room...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-10-21
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development, Special Emphasis Panel, Topics In Female Reproduction. Date... Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-01
... Institute of Child Health and Human Development Special Emphasis Panel; Theory of Mind Intervention. Date... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Kennedy Shriver National Institute, of Child Health and Human Development, NIH, 6100 Executive Blvd., Room...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-23
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; ZHD1 DSR-Y 41 1. Date: November 15... Kennedy Shriver National Institute of Child Health And Human Development, NIH, 6100 Executive Blvd., Room...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-03-28
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; ZHD1 DSR-H MR 1. Date: April 23... Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-07
... Institute of Child Health and Human Development Special Emphasis Panel, Diabetes Risk Across Women's... National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d... Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room...
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Reddy, Uma M; Abuhamad, Alfred Z; Levine, Deborah; Saade, George R
2014-05-01
Given that practice variation exists in the frequency and performance of ultrasound and magnetic resonance imaging (MRI) in pregnancy, the Eunice Kennedy Shriver National Institute of Child Health and Human Development hosted a workshop to address indications for ultrasound and MRI in pregnancy, to discuss when and how often these studies should be performed, to consider recommendations for optimizing yield and cost effectiveness, and to identify research opportunities. This article is the executive summary of the workshop.
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Reddy, Uma M; Abuhamad, Alfred Z; Levine, Deborah; Saade, George R
2014-05-01
Given that practice variation exists in the frequency and performance of ultrasound and magnetic resonance imaging (MRI) in pregnancy, the Eunice Kennedy Shriver National Institute of Child Health and Human Development hosted a workshop to address indications for ultrasound and MRI in pregnancy, to discuss when and how often these studies should be performed, to consider recommendations for optimizing yield and cost effectiveness, and to identify research opportunities. This article is the executive summary of the workshop.
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Reddy, Uma M; Abuhamad, Alfred Z; Levine, Deborah; Saade, George R
2014-05-01
Given that practice variation exists in the frequency and performance of ultrasound and magnetic resonance imaging in pregnancy, the Eunice Kennedy Shriver National Institute of Child Health and Human Development hosted a workshop to address indications for ultrasound and magnetic resonance imaging in pregnancy, to discuss when and how often these studies should be performed, to consider recommendations for optimizing yield and cost-effectiveness and to identify research opportunities. This article is the executive summary of the workshop. Published by Mosby, Inc.
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-12-30
... National Institute for Child Health and Human Development SUMMARY: In compliance with the requirement of... proposed data collection projects, the Eunice Kennedy Shriver National Institute of Child Health and Human... Science Policy, Analysis and Communication, Eunice Kennedy Shriver National Institute of Child Health and...
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Giacoia, George P; Taylor-Zapata, Perdita; Mattison, Donald
2008-11-01
The Pediatric Formulation Initiative (PFI) is a project of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The PFI was established to address the issue of the lack of appropriate formulations in children and to use this activity as a means to improve pediatric formulations, as mandated by the Best Pharmaceuticals for Children Act of 2002 and 2007. The PFI began in 2005 with the formation of 3 working groups-Scientific, Economics, and Taste and Flavor. These groups began the process of identifying issues, gathering needed information, and considering possible ways to overcome barriers to the development of pediatric drug formulations. The purpose of this supplement was to provide details of the working groups' activities through presentation of full-length articles. Also presented is an article that discusses the 2007 European Union (EU) regulation on medicinal products for pediatric use. Information for this article was gathered from the proceedings of a PFI workshop, sponsored by the NICHD, that was held in Bethesda, Maryland, on December 6 and 7, 2005, as well as postworkshop discussions of the different working groups. The increased awareness that the majority of medications used today have not been labeled for use in children, and have not been tested to define safety, efficacy, and appropriate dosing, has led to the passage of legislation in the United States and in the EU to create incentives to stimulate the testing of drugs in this special population. It is imperative that the problems associated with the compounding and use of extemporaneous formulations as described in this supplement be addressed. Regulatory barriers to the availability of commercially developed pediatric formulations in different countries will need to be minimized or removed. New drug delivery systems will need to be tested and made available to pediatric patients. Further research in the mediators of bitter taste and study of taste blockers
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-04-01
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Initial Review Group; Biobehavioral and Behavioral Sciences... Shriver National Institute of Child Health And Human Development, NIH, 6100 Executive Blvd., Room 5B01...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-10-23
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; ZHD1 DSR-Z. Date: November 13, 2012... Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room 5B01...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-23
... National Institute of Child Health and Human Development (NICHD); Notice of Meeting Pursuant to the NIH... National Institute of Child Health and Human Development (NICHD) will host a meeting to enable public... Shriver National Institute of Child Health and Human Development. Dates and Times: March 7, 2012, at 3 p.m...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-21
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; ZHD1 DSR-Z 41 2. Date: July 19, 2012... Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Boulevard, Room 5B01...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-06
... National Institute of Child Health & Human Development; Notice of Closed Meeting Pursuant to section 10(d... Institute of Child Health and Human Development Special Emphasis Panel; ZHD1 DSR-W 90. Date: June 26, 2012... Shriver National Institute of Child Health And Human Development, NIH, 6100 Executive Boulevard, Room 5B01...
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Rep. Hoyer, Steny H. [D-MD-5
2010-05-05
Senate - 05/20/2010 Received in the Senate and Read twice and referred to the Committee on Health, Education, Labor, and Pensions. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:
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Sen. Harkin, Tom [D-IA
2011-05-26
Senate - 05/26/2011 Read twice and referred to the Committee on Health, Education, Labor, and Pensions. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:
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Sen. Harkin, Tom [D-IA
2010-04-29
Senate - 04/29/2010 Read twice and referred to the Committee on Health, Education, Labor, and Pensions. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:
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Rep. Hoyer, Steny H. [D-MD-5
2010-04-29
House - 05/27/2010 Referred to the Subcommittee on Early Childhood, Elementary, and Secondary Education. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:
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Sen. Harkin, Tom [D-IA
2013-03-06
Senate - 03/06/2013 Read twice and referred to the Committee on Health, Education, Labor, and Pensions. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-29
... Institute of Child Health and Human Development Special Emphasis Panel; The Ontogeny of Infant Detection of... National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d... Shriver National Institute of Child Health and Human Development, NIH, 6100 Executive Blvd., Room 5B01...
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Spong, Catherine Y; Berghella, Vincenzo; Wenstrom, Katharine D; Mercer, Brian M; Saade, George R
2012-11-01
With more than one third of pregnancies in the United States being delivered by cesarean and the growing knowledge of morbidities associated with repeat cesarean deliveries, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the Society for Maternal-Fetal Medicine, and the American College of Obstetricians and Gynecologists convened a workshop to address the concept of preventing the first cesarean delivery. The available information on maternal and fetal factors, labor management and induction, and nonmedical factors leading to the first cesarean delivery was reviewed as well as the implications of the first cesarean delivery on future reproductive health. Key points were identified to assist with reduction in cesarean delivery rates including that labor induction should be performed primarily for medical indication; if done for nonmedical indications, the gestational age should be at least 39 weeks or more and the cervix should be favorable, especially in the nulliparous patient. Review of the current literature demonstrates the importance of adhering to appropriate definitions for failed induction and arrest of labor progress. The diagnosis of "failed induction" should only be made after an adequate attempt. Adequate time for normal latent and active phases of the first stage, and for the second stage, should be allowed as long as the maternal and fetal conditions permit. The adequate time for each of these stages appears to be longer than traditionally estimated. Operative vaginal delivery is an acceptable birth method when indicated and can safely prevent cesarean delivery. Given the progressively declining use, it is critical that training and experience in operative vaginal delivery are facilitated and encouraged. When discussing the first cesarean delivery with a patient, counseling should include its effect on future reproductive health.
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Spong, Catherine Y.; Berghella, Vincenzo; Wenstrom, Katharine D.; Mercer, Brian M.; Saade, George R.
2012-01-01
With over one-third of pregnancies in the United States being delivered by cesarean and the growing knowledge of morbidities associated with repeat cesarean deliveries, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the Society for Maternal-Fetal Medicine, and the American College of Obstetricians and Gynecologists convened a workshop to address the concept of preventing the first cesarean. The available information on maternal and fetal factors, labor management and induction, and non-medical factors leading to the first cesarean were reviewed as well as the implications of the first cesarean on future reproductive health. Key points were identified to assist with reduction in cesarean rates including that labor induction should be performed primarily for medical indication; if done for non-medical indications, the gestational age should be at least 39 weeks or more and the cervix should be favorable, especially in the nulliparous patient. Review of the current literature demonstrates the importance of adhering to appropriate definitions for failed induction and arrest of labor progress. The diagnosis of “failed induction” should only be made after an adequate attempt. Adequate time for normal latent and active phases of the first stage, and for the second stage, should be allowed, as long as the maternal and fetal conditions permit. The adequate time for each of these stages appears to be longer than traditionally estimated. Operative vaginal delivery is an acceptable birth method when indicated, and can safely prevent cesarean delivery. Given the progressively declining use, it is critical that training and experience in operative vaginal delivery is facilitated and encouraged. When discussing the first cesarean with a patient, counseling should include its effect on future reproductive health. PMID:23090537
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Reddy, Uma M; Davis, Jonathan M; Ren, Zhaoxia; Greene, Michael F
2017-07-01
In April 2016, the Eunice Kennedy Shriver National Institute of Child Health and Human Development invited experts to a workshop to address numerous knowledge gaps and to review the evidence for the screening and management of opioid use in pregnancy and neonatal abstinence syndrome. The rising prevalence of opioid use in pregnancy has led to a concomitant dramatic fivefold increase in neonatal abstinence syndrome over the past decade. Experts from diverse disciplines addressed research gaps in the following areas: 1) optimal screening for opioid use in pregnancy; 2) complications of pregnancy associated with opioid use; 3) appropriate treatments for pregnant women with opioid use disorders; 4) the best approaches for detecting, treating, and managing newborns with neonatal abstinence syndrome; and 5) the long-term effects of prenatal opioid exposure on children. Workshop participants identified key scientific opportunities to advance the understanding of opioid use disorders in pregnancy and to improve outcomes for affected women, their children, and their families. This article provides a summary of the workshop presentations and discussions.
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Genetics Home Reference: proopiomelanocortin deficiency
... POMC deficiency, but they may have an increased risk of obesity. Related Information ... Eunice Kennedy Shriver National Institute of Child Health and Human Development: How are Obesity and Overweight ...
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What Are the Factors That Put a Pregnancy at Risk?
... www.healthychildren.org/English/ages-stages/teen/dating-sex/Pages/Teenage-Pregnancy.aspx Eunice Kennedy Shriver National Institute of Child Health & Human Development. (2007). Older Mothers More Likely Than Younger Mothers to Deliver by ...
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Genetics Home Reference: McCune-Albright syndrome
... while other cells have the mutated version. This phenomenon is called mosaicism . The severity of this disorder ... 1 link) Eunice Kennedy Shriver National Institute for Child Health and Human Development Educational Resources (3 links) ...
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Toilet Training: MedlinePlus Health Topic
... Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine) Article: Defecation-Specific Behavior in Children with Functional Defecation ... Eunice Kennedy Shriver National Institute of Child Health and Human Development (National Institute of Child Health and Human ...
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NIH Institutes and MLN MedlinePlus Advisory Board | NIH MedlinePlus the Magazine
... Collins-Lee, National Eye Institute Kathleen Cravedi, National Library of Medicine (ex-officio) Stephanie Dailey, National Institute on Aging Meredith Daly, Eunice Kennedy Shriver National Institute of Child Health and Human Development Marian Emr, National Institute of Neurological Disorders and ...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-07
... precision requirements or power calculations that justify the proposed sample size, the expected response... Qualitative Feedback on Agency Service Delivery AGENCY: National Institutes of Health, Eunice Kennedy Shriver...): ``Generic Clearance for the Collection of Qualitative Feedback on Agency Service Delivery '' to OMB for...
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Federal Register 2010, 2011, 2012, 2013, 2014
2013-08-14
... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001... American Society for Pediatric Gastroenterology, Hepatology, and Nutrition, and the Pediatric IBD... patients and representatives from the Eunice Kennedy Shriver National Institute of Child Health and Human...
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78 FR 64520 - Statement of Organization, Functions, and Delegations of Authority
Federal Register 2010, 2011, 2012, 2013, 2014
2013-10-29
... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Statement of Organization... Organization, Functions, and Delegations of Authority for the Department of Health and Human Services (40 FR... Development (NICHD). Section N-T, Organization and Functions, under the heading Eunice Kennedy Shriver...
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Ilekis, John V.; Tsilou, Ekaterini; Fisher, Susan; Abrahams, Vikki M.; Soares, Michael J.; Cross, James C.; Zamudio, Stacy; Illsley, Nicholas P.; Myatt, Leslie; Colvis, Christine; Costantine, Maged M.; Haas, David M.; Sadovsky, Yoel; Weiner, Carl; Rytting, Erik; Bidwell, Gene
2016-01-01
Although much progress is being made in understanding the molecular pathways in the placenta involved in the pathophysiology of pregnancy related disorders, a significant gap exists in utilizing this information for developing new drug therapies to improve pregnancy outcome. On March 5–6, 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health sponsored a two day workshop titled Placental Origins of Adverse Pregnancy Outcomes: Potential Molecular Targets to begin to address this gap. Particular emphasis was given in the identification of important molecular pathways that could serve as drug targets and the advantages and disadvantages of targeting these particular pathways. This article is a summary of the proceedings of this workshop. A broad number of topics were covered ranging from basic placental biology to clinical trials. This included research in the basic biology of placentation, such as trophoblast migration and spiral artery remodeling, and trophoblast sensing and response to infectious and non-infectious agents. Research findings in these areas will be critical for formulating developing future treatments and developing therapies for the prevention of a number of pregnancy disorders of placental origin including preeclampsia, fetal growth restriction, and uterine inflammation. Research was also presented summarizing ongoing clinical efforts in the U.S. and in Europe testing novel interventions for preeclampsia and fetal growth restriction, including agents such as oral arginine supplementation, sildenafil, pravastatin, gene therapy using virally-delivered vascular endothelial growth factor, and oxygen supplementation therapy. Strategies were also proposed to improve fetal growth by enhancing nutrient transport to the fetus by modulating their placental transporters, as well as targeting placental mitochondrial dysfunction and oxidative stress to improve placental health. The roles
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USDA-ARS?s Scientific Manuscript database
The Best Pharmaceuticals for Children Act of 2002 mandated that the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) carries out critical reviews of the gaps in knowledge and unmet needs regarding safe and effective pharmacologic treatment of infants, children,...
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ERIC Educational Resources Information Center
McElwain, Nancy L.; Booth-Laforce, Cathryn; Wu, Xiaoying
2011-01-01
Utilizing data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development's Study of Early Child Care and Youth Development, we investigated mothers' talk about mental states during play with their 24-month-old children as a mechanism though which infant-mother attachment was associated with children's later…
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ERIC Educational Resources Information Center
Institute of Education Sciences, 2013
2013-01-01
In August, IES worked with the National Science Foundation and the Eunice Kennedy Shriver National Institute of Child Health and Human Development to convene a technical working group to discuss research objectives related to college- and career-ready standards in English language arts and mathematics. Forty people (including researchers,…
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ERIC Educational Resources Information Center
Mott (C.S.) Foundation, Flint, MI.
Proceedings of a conference on adolescent pregnancy are presented in this document. Eunice Kennedy Shriver's opening address, in which she urged the building of "communities of caring" is summarized, as is the address by Gina C. Adams who discussed recent findings on the topic of adolescent pregnancy. Several programs developed to address the…
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Discover the NICHD. NIH Publication No. 13-7976
ERIC Educational Resources Information Center
National Institute of Child Health and Human Development (NICHD), 2013
2013-01-01
This four-page document provides an overview of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), a health research agency within the federal government. NICHD is a part of the National Institutes of Health in the U.S Department of Health and Human Services. This brief report describes the mission of…
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Diffusion MRI and the Detection of Alterations Following Traumatic Brain Injury
2017-06-13
Bioengineering, National Institutes of Health , Bethesda, Maryland 2Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National...Institute of Child Health and Human Development, National Institutes of Health , Bethesda, Maryland 3Henry M. Jackson Foundation for the Advancement of...Military Medicine, Inc, Bethesda, Maryland 4Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda
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Improved Antibodies Against ERBB4/HER4 | NCI Technology Transfer Center | TTC
The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Section on Molecular Neurobiology seeks parties interested in licensing or collaborative research to further evaluate or commercialize specific rabbit monoclonal antibodies generated against the ErbB4 receptor (also known as HER4) that have been validated for specificity using tissue sections and extracts from ErbB4 knockout mice.
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Shankaran, Seetha; Laptook, Abbot R.; McDonald, Scott A.; Hintz, Susan R; Barnes, Patrick D.; Das, Abhik; Higgins, Rosemary D.
2016-01-01
Infants with perinatal sentinel events in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Hypothermia for Encephalopathy Trial had more basal ganglia and thalamus lesions on brain magnetic resonance imaging but similar neurodevelopmental outcomes at 18 months of age than infants without perinatal sentinel events. Outcomes correlated with the neonatal magnetic resonance imaging findings. PMID:27776752
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2011-01-01
In its nearly 5 decades of existence, the Eunice Kennedy Shriver National Institute of Child Health and Human Development has expended $23 billion in conducting and supporting research and translating discoveries to practice. The resulting dramatic impact on peoples' lives and improved health for children and families, chronicled herein, are a testament to the benefits of having this institute at the National Institutes of Health. PMID:21199851
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Researchers at The Eunice Kennedy Shriver National Institute on Child Health and Human Development (NICHD) have discovered monoclonal antibodies that bind to matrilin-3, a protein specifically expressed in cartilage tissue, that could be used for treating or inhibiting growth plate disorders, such as a skeletal dysplasia or short stature. The monoclonal antibodies can also be used to target therapeutic agents, such as anti-arthritis agents, to cartilage tissue. NICHD seeks statements of capability or interest from parties interested in collaborative research to co-develop, evaluate, or commercialize treatment of skeletal disorders using targeting antibodies.
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Researchers at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (“NICHD”), seek CRADA partner or collaboration for development of agents to treat multiple sclerosis or other conditions associated with myelin remodeling by administering an agent that inhibits cleavage of Neurofascin 155 or Caspr1. The agent could be a thrombin inhibitor, an agent that inhibits thrombin expression, an anti-thrombin antibody that specifically inhibits thrombin mediated cleavage of Neurofascin 155, a mutated version or fragment of Neurofascin 155 or Caspr1, or antibodies to Neurofascin 155 or Caspr1.
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Labor management evidence update: potential to minimize risk of cesarean birth in healthy women.
Simpson, Kathleen Rice
2014-01-01
New evidence regarding normal parameters of labor progress for healthy women has the potential to minimize risk of cesarean birth and thereby enhance current and future maternal well-being if clinicians apply the research findings to obstetric practice. The economic and reproductive health consequences of the increasing cesarean birth rate in the United States are considerable; therefore, action on this issue by all stakeholders is necessary. Review and integration of the recent recommendations for labor management from experts convened by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the American College of Obstetricians and Gynecologists, and the Society for Maternal-Fetal Medicine are required to make maternity care in the United States as safe as possible.
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Wu, Xuwen; Sun, Ruiping; Liu, Ruiyu; Xu, Kuidong
2013-01-01
A taxonomic study of Eunice species based on material deposited in the Marine Biological Museum of the Chinese Academy of Sciences (MBMCAS) including recently collected specimens from coastal regions of Hainan Island, yielded two new species: Eunice hainanensis n. sp. and E. carrerai n. sp. Both species were collected from dead coral rocks in the reefs of the coastal region of Hainan Island, northern South China Sea. Eunice hainanensis has translucent bidentate subacicular hooks and branchiae present over an extensive region of the body. Within the Eunice group possessing these characters, the new species highly resembles E. schizobranchia Claparède, 1870 in having a numerous chaetigers and a very late start of branchiae (348-570 chaetigers with branchiae from chaetigers 69-72 vs. 731 chaetigers with branchiae from chaetiger 67). However, the two species differ by the presence of the maxillary plate VI (MxVI) in the new species (vs. absent in the latter). Besides, E. hainanensis is much smaller (1.7-1.9 mm vs. 5 mm in maximal width). Eunice carrerai belongs to the Eunice group that has dark bidentate subacicular hooks and branchiae present over an extensive region of the body. It can be distinguished from similar congeners that have the branchiae starting from chaetigers 3-4 and prostomial appendages with moniliform articulations by a combination of characters such as the presence of MxVI, notopodial articulations limited to anterior chaetigers, peristomial cirri articulated and extending to anterior edge of first peristomial ring. A key to 16 species of Eunice identified from China seas in the material examined with notes on their distribution is provided. The major characters of these species are briefly summarized.
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Antenatal Testing – A Reevaluation
Signore, Caroline; Freeman, Roger K.; Spong, Catherine Y.
2009-01-01
In August 2007, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institutes of Health Office of Rare Diseases, the American College of Obstetricians and Gynecologists, and the American Academy of Pediatrics cosponsored a 2-day workshop to reassess the body of evidence supporting antepartum assessment of fetal well-being, identify key gaps in the evidence, and formulate recommendations for further research. Participants included experts in obstetrics and fetal physiology, and representatives from relevant stakeholder groups and organizations. This article is a summary of the discussions at the workshop, including synopses of oral presentations on the epidemiology of stillbirth and fetal neurological injury, fetal physiology, techniques for antenatal monitoring, and maternal and fetal indications for monitoring. Finally, a synthesis of recommendations for further research compiled from three breakout workgroups is presented. PMID:19300336
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Das, Abhik; Tyson, Jon; Pedroza, Claudia; Schmidt, Barbara; Gantz, Marie; Wallace, Dennis; Truog, William E; Higgins, Rosemary D
2016-10-01
Impressive advances in neonatology have occurred over the 30 years of life of The Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN). However, substantial room for improvement remains in investigating and further developing the evidence base for improving outcomes among the extremely premature. We discuss some of the specific methodological challenges in the statistical design and analysis of randomized trials and observational studies in this population. Challenges faced by the NRN include designing trials for unusual or rare outcomes, accounting for and explaining center variations, identifying other subgroup differences, and balancing safety and efficacy concerns between short-term hospital outcomes and longer-term neurodevelopmental outcomes. In conclusion, the constellation of unique patient characteristics in neonates calls for broad understanding and careful consideration of the issues identified in this article for conducting rigorous studies in this population. Copyright © 2016 Elsevier Inc. All rights reserved.
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Inhaled Nitric Oxide Therapy for Pulmonary Disorders of the Term and Preterm Infant
Sokol, Gregory M.; Konduri, G. Ganesh; Van Meurs, Krisa P.
2016-01-01
The 21st century began with the FDA approval of inhaled nitric oxide therapy for the treatment of neonatal hypoxic respiratory failure associated with pulmonary hypertension in recognition of the two randomized clinical trials demostrating a significant reduction in the need for extracorporeal support in the term and near-term infant. Inhaled nitric oxide is one of only a few therapeutic agents approved for use through clinical investigations primarily in the neonate. This article provides an overview of the pertinent biology and chemistry of nitric oxide, discusses potential toxicities, and reviews the results of pertinent clinical investigations and large randomized clinical trials including neurodevelopmental follow-up in term and preterm neonates. The clinical investigations conducted by the Eunice Kennedy Shriver NICHD Neonatal Research Network will be discussed and placed in context with other pertinent clinical investigations exploring the efficacy of inhaled nitric oxide therapy in neonatal hypoxic respiratory failure. PMID:27480246
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A new species of Eunice (Polychaeta: Eunicidae) from Hainan Island, South China Sea
NASA Astrophysics Data System (ADS)
Wu, Xuwen; Sun, Ruiping; Liu, Ruiyu
2013-01-01
A taxonomic survey of benthic marine animals from coastal regions of Hainan Island, South China Sea, revealed specimens of a new species of Eunice (Polychaeta: Eunicida: Eunicidae), Eunice uschakovi n. sp., collected from the intertidal zone. The species belongs to the group of Eunice that has yellow tridentate subacicular hooks and branchiae scattered over an extensive region of the body. It resembles E. miurai and E. havaica in having both bidentate and tridentate falcigers, but can be readily distinguished by branchial features. Comparisons between E. uschakovi and the two related species are presented.
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Prenatal Imaging: Ultrasonography and Magnetic Resonance Imaging
Reddy, Uma M.; Filly, Roy A.; Copel, Joshua A.
2009-01-01
The Eunice Kennedy Shriver National Institute of Child Health and Human Development held a workshop on September 18–19, 2006, to summarize the available evidence on the role and performance of current fetal imaging technology and to establish a research agenda. Ultrasonography is the imaging modality of choice for pregnancy evaluation due to its relatively low cost, real-time capability, safety, and operator comfort and experience. First-trimester ultrasonography extends the available window for fetal observation and raises the possibility of performing an early anatomic survey. Three-dimensional ultrasonography has the potential to expand the clinical application of ultrasonography by permitting local acquisition of volumes and remote review and interpretation at specialized centers. New advances allow performance of fetal magnetic resonance imaging (MRI) without maternal or fetal sedation, with improved characterization and prediction of prognosis of certain fetal central nervous system anomalies such as ventriculomegaly when compared with ultrasonography. Fewer data exist on the usefulness of fetal MRI for non–central nervous system anomalies. PMID:18591320
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Astronauts Onizuka and Shriver pose in middeck
1985-01-25
51C-08-017 (24-27 Jan 1985) --- Astronaut Ellison S. Onizuka, mission specialist, (left) turns 180 degrees near airlock hatch, while Loren J. Shriver, pilot, records verbal mission - pertinent notes. For orientation hold the picture with lockers on right.
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2010-01-28
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2012-04-19
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2013-07-24
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2013-11-25
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2011-05-09
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2010-10-20
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2013-05-10
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2010-12-27
... Support for Human Embryonic Stem Cell Research Update. Place: National Institutes of Health, Building 31...; 93.865, Research for Mothers and Children; 93.929, Center for Medical Rehabilitation Research; 93.209...
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Astronauts Onizuka and Shriver pose in middeck
NASA Technical Reports Server (NTRS)
1985-01-01
Mission specialist Ellison S. Onizuka, wearing the Kamakze headband, appears to be keeping a sleeping Loren J. Shriver, pilot, from floating in his sleep restraints through the middeck of the Discovery during the 51-C mission. Behind them is a decal which reads 'Aim High, Air Force'.
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ERIC Educational Resources Information Center
Nelson, Elaine M.
2009-01-01
Eunice Woodhull Stabler. Eunice Stabler, or Thataweson , meaning "Pale Woman of the Bird Clan," was born in 1885 on the Omaha Reservation in northeastern Nebraska. During a period of continued transitions and federal assimilation efforts directed at the Omaha people--and Indigenous people throughout the United States--Stabler remained…
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2012-06-07
... Institute of Child Health and Human Development Special Emphasis Panel, Asthma Control During Pregnancy: Predictors of Variability in Maternal Impairment Due to Asthma and Associated Maternal and Pregnancy Outcomes...
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2013-02-27
... could disclose confidential trade secrets or commercial property such as patentable material, and... Institute of Child Health and Human Development Initial Review Group; Function, Integration, and...
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2013-11-21
... research opportunities and needs; Renewing research infrastructure network program. Place: Hyatt Regency...., Acting Director, National Center for Medical Rehabilitation Research (NCMRR), Director, Biological...
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-02-17
..., ``Male Reproduction.'' Date: March 14, 2012. Time: 2 p.m. to 4 p.m. Agenda: To review and evaluate grant..., Center for Medical Rehabilitation Research; 93.209, Contraception and Infertility Loan Repayment Program...
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2010-09-03
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Federal Register 2010, 2011, 2012, 2013, 2014
2012-03-08
... Institute of Child Health and Human Development Special Emphasis Panel; A Low Molecular Weight Thyroid- Stimulating Hormone Receptor Agonist for Thyroid Cancer (SBIR Contract) Date: March 28, 2012. Time: 3 p.m. to...
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2010-06-17
...: National Institute of Child Health and Human Development Special Emphasis Panel; Novel Technologies in... National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d... Scientific Review, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room...
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2010-05-18
... secrets or commercial property such as patentable material, and personal information concerning...; (3) a discussion on the planning of the NICHD Science Vision; and other business of the Council...
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2010-06-24
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2010-05-12
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2012-02-24
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2010-07-07
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2010-09-03
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2013-02-21
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2010-07-07
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2010-07-07
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2010-09-03
... National Institute of Child Health and Human Development; Notice of Closed Meeting Pursuant to section 10(d...: National Institute of Child Health and Human Development Special Emphasis Panel; Review of T32 Applications... Health and Human Development, NIH, 6100 Executive Blvd., Room 5B01, Bethesda, MD 20892, 301-435-6680...
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2012-01-04
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2012-03-20
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2012-02-01
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2012-07-24
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2010-06-25
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2010-01-08
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2010-06-17
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2010-06-29
... Institute of Child Health and Human Development Special Emphasis Panel ``STEM CELLS''. Date: July 20, 2010... Nos. 93.864, Population Research; 93.865, Research for Mothers and Children; 93.929, Center for...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-08
... Inhibitors for Down Syndrome. Date: July 26, 2010. Time: 2 p.m. to 5 p.m. Agenda: To review and evaluate...) of the Federal Advisory Committee Act, as amended (5 U.S.C. App.), notice is hereby given of the... sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions...
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STS-46 Commander Shriver eats candy (M&Ms) on OV-104's aft flight deck
1992-08-08
STS046-35-013 (31 July-8 Aug. 1992) --- Astronaut Loren J. Shriver, STS-46 commander, pursues several floating chocolate candies on the flight deck of the Space Shuttle Atlantis as it makes one of its 127 total orbits for the eight-day mission. Shriver, wearing a headset for communications with ground controllers, joined four other NASA astronauts and two European scientists for the mission.
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Instruction, Teacher–Student Relations, and Math Achievement Trajectories in Elementary School
Crosnoe, Robert; Morrison, Fred; Burchinal, Margaret; Pianta, Robert; Keating, Daniel; Friedman, Sarah L.; Clarke-Stewart, K. Alison
2010-01-01
Children enter elementary school with widely different skill levels in core subjects. Whether because of differences in aptitude or in preparedness, these initial skill differences often translate into systematic disparities in achievement over time. How can teachers reduce these disparities? Three possibilities are to offer basic skills training, to expose students to higher order instruction, or to provide socioemotional support. Repeated measures analyses of longitudinal data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Study of Early Child Care and Youth Development revealed that children with low, average, or high math skills prior to elementary school followed different but parallel trajectories of math achievement up through fifth grade. When enrolled in classes with inference-based instruction, however, the initially least skilled children narrowed the achievement gap as long as they did not have conflictual relations with their teachers. They did not make this kind of progress if they were in classes focused exclusively on basic skills instruction or if they were in inference-focused classes but had conflictual relations with teachers. PMID:20657743
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DASH, the data and specimen hub of the National Institute of Child Health and Human Development
Hazra, Rohan; Tenney, Susan; Shlionskaya, Alexandra; Samavedam, Rajni; Baxter, Kristin; Ilekis, John; Weck, Jennifer; Willinger, Marian; Grave, Gilman; Tsilou, Katerina; Songco, David
2018-01-01
The benefits of data sharing are well-established and an increasing number of policies require that data be shared upon publication of the main study findings. As data sharing becomes the new norm, there is a heightened need for additional resources to drive efficient data reuse. This article describes the development and implementation of the Data and Specimen Hub (DASH) by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to promote data sharing from NICHD-funded studies and enable researchers to comply with NIH data sharing policies. DASH’s flexible architecture is designed to archive diverse data types and formats from NICHD’s broad scientific portfolio in a manner that promotes FAIR data sharing principles. Performance of DASH over two years since launch is promising: the number of available studies and data requests are growing; three manuscripts have been published from data reanalysis, all within two years of access. Critical success factors included NICHD leadership commitment, stakeholder engagement and close coordination between the governance body and technical team. PMID:29557977
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STS-46 Commander Shriver eats candy (M and Ms) on OV-104's aft flight deck
NASA Technical Reports Server (NTRS)
1992-01-01
STS-46 Commander Loren J. Shriver, wearing a communications kit assembly headset and with his mouth open, pursues several floating chocolate-covered peanut candies (M and Ms) on the aft flight deck of Atlantis, Orbiter Vehicle (OV) 104. Shriver is positioned in front of overhead window W7. Outside the window the cloud-covered surface of the Earth and the Earth's limb are visible.
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Improving Safe and Effective Use of Drugs in Pregnancy and Lactation: Workshop Summary.
Riley, Laura E; Cahill, Alison G; Beigi, Richard; Savich, Renate; Saade, George
2017-07-01
In February 2015, given high rates of use of medications by pregnant women and the relative lack of data on safety and efficacy of many drugs utilized in pregnancy, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the Society for Maternal-Fetal Medicine (SMFM), the American College of Obstetricians and Gynecologists (ACOG), and the American Academy of Pediatrics (AAP) convened a group of experts to review the "current" state of the clinical care and science regarding medication use during the perinatal period. The expert panel chose select medications to demonstrate what existing safety and efficacy data may be available for clinicians and patients when making decisions about use in pregnancy or lactation. Furthermore, these example medications also provided opportunities to highlight where data are lacking, thus forming a list of research gaps. Last, after reviewing the existing vaccine safety surveillance system as well as the legislative history surrounding the use of drugs for pediatric diseases, the expert panel made specific recommendations concerning policy efforts to stimulate more research and regulatory attention on drugs for pregnant and lactating women. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
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Patient Safety in the Context of Neonatal Intensive Care: Research and Educational Opportunities
Raju, Tonse N. K.; Suresh, Gautham; Higgins, Rosemary D.
2012-01-01
Case reports and observational studies continue to report adverse events from medical errors. However, despite considerable attention to patient safety in the popular media, this topic is not a regular component of medical education, and much research needs to be carried out to understand the causes, consequences, and prevention of healthcare-related adverse events during neonatal intensive care. To address the knowledge gaps and to formulate a research and educational agenda in neonatology, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) invited a panel of experts to a workshop in August 2010. Patient safety issues discussed were: the reasons for errors, including systems design, working conditions, and worker fatigue; a need to develop a “culture” of patient safety; the role of electronic medical records, information technology, and simulators in reducing errors; error disclosure practices; medico-legal concerns; and educational needs. Specific neonatology-related topics discussed were: errors during resuscitation, mechanical ventilation, and performance of invasive procedures; medication errors including those associated with milk feedings; diagnostic errors; and misidentification of patients. This article provides an executive summary of the workshop. PMID:21386749
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Influence of Eunice norvegica on feeding and calcification in the coral Lophelia pertusa
NASA Astrophysics Data System (ADS)
Mueller, C. E.; van Oevelen, D.; Middelburg, J. J.; Lundälv, T.
2012-04-01
Lophelia pertusa is the main framework building cold-water coral in the North Atlantic. It forms complex reef structures, extending up to several km in length and several meters in hight. Many species are attracted by the coral frame work, forming a highly diverse community within the reef. Although most work has focused on the corals, the functioning of the system also depends on interactions between corals and associated species. A particular example is the Polychaete Eunice norvegica that lives in close association with the coral host. The Polychaete builds a thin texture-tube between living coral branches and stimulates the coral to calcify the tube. This process strengthens the reef framwork by thickening and connecting coral brances and thereby acts as a positive feedback on the development of large reef structures. This comes however at an metabolic cost for the coral due to the enhanced calcificationrates. Another negative feedback for cold-water coral may be food related, since aquaria observations have shown that Eunice occasionally steels food from its host coral. In this study we investigated the interactions between the coral and polychaete related to calcification and food partitioning for two food types (algae and Artemia). The uptake of 13C and 15N labeled food sources by the worm and the coral was studied in chambers with only corals, only the polychaete and both species present. After 7 days, corals and worms were analyzed for isotope incorporation in bulk tissue and skeleton samples and specific fatty acids (13C) using GC-c-IRMS (gas-chromatography-combustion-isotope ratio mass spectrometry). Corals that were kept in the presence of Eunice indeed showed a higher calcification rates of 7.4 ug C (day* g dw coral)-1, evidencing the stimulation of calcification by Eunice. Interestingly, food uptake of algae and Artemia was higher in the coral-worm treatment for both species as compared to the single species treatments. These results shed new light on
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Cahill, Alison G; Tuuli, Methodius G; Stout, Molly J; López, Julia D; Macones, George A
2018-05-01
Intrapartum electronic fetal monitoring is the most commonly used tool in obstetrics in the United States; however, which electronic fetal monitoring patterns predict acidemia remains unclear. This study was designed to describe the frequency of patterns seen in labor using modern nomenclature, and to test the hypothesis that visually interpreted patterns are associated with acidemia and morbidities in term infants. We further identified patterns prior to delivery, alone or in combination, predictive of acidemia and neonatal morbidity. This was a prospective cohort study of 8580 women from 2010 through 2015. Patients were all consecutive women laboring at ≥37 weeks' gestation with a singleton cephalic fetus. Electronic fetal monitoring patterns during the 120 minutes prior to delivery were interpreted in 10-minute epochs. Interpretation included the category system and individual electronic fetal monitoring patterns per the Eunice Kennedy Shriver National Institute of Child Health and Human Development criteria as well as novel patterns. The primary outcome was fetal acidemia (umbilical artery pH ≤7.10); neonatal morbidities were also assessed. Final regression models for acidemia adjusted for nulliparity, pregestational diabetes, and advanced maternal age. Area under the receiver operating characteristic curves were used to assess the test characteristics of individual models for acidemia and neonatal morbidity. Of 8580 women, 149 (1.7%) delivered acidemic infants. Composite neonatal morbidity was diagnosed in 757 (8.8%) neonates within the total cohort. Persistent category I, and 10-minute period of category III, were significantly associated with normal pH and acidemia, respectively. Total deceleration area was most discriminative of acidemia (area under the receiver operating characteristic curves, 0.76; 95% confidence interval, 0.72-0.80), and deceleration area with any 10 minutes of tachycardia had the greatest discriminative ability for neonatal
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2003-12-19
KENNEDY SPACE CENTER, FLA. -- From left, United Space Alliance (USA) Deputy Space Shuttle Program Manager of Operations Loren Shriver, USA Associate Program Manager of Ground Operations Andy Allen, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and USA Vice President and Space Shuttle Program Manager Howard DeCastro examine a tile used in the Shuttle's Thermal Protection System (TPS) in KSC's TPS Facility. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.
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Schetter, Christine Dunkel; Schafer, Peter; Lanzi, Robin Gaines; Clark-Kauffman, Elizabeth; Raju, Tonse N. K.; Hillemeier, Marianne M.
2015-01-01
Health disparities are large and persistent gaps in the rates of disease and death between racial/ethnic and socioeconomic status subgroups in the population. Stress is a major pathway hypothesized to explain such disparities. The Eunice Kennedy Shriver National Institute of Child Health and Human Development formed a community/research collaborative—the Community Child Health Network—to investigate disparities in maternal and child health in five high-risk communities. Using community participation methods, we enrolled a large cohort of African American/Black, Latino/Hispanic, and non-Hispanic/White mothers and fathers of newborns at the time of birth and followed them over 2 years. A majority had household incomes near or below the federal poverty level. Home interviews yielded detailed information regarding multiple types of stress such as major life events and many forms of chronic stress including racism. Several forms of stress varied markedly by racial/ethnic group and income, with decreasing stress as income increased among Caucasians but not among African Americans; other forms of stress varied by race/ethnicity or poverty alone. We conclude that greater sophistication in studying the many forms of stress and community partnership is necessary to uncover the mechanisms underlying health disparities in poor and ethnic-minority families and to implement community health interventions. PMID:26173227
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Oster-Granite, Mary Lou; Parisi, Melissa A.; Abbeduto, Leonard; Berlin, Dorit S.; Bodine, Cathy; Bynum, Dana; Capone, George; Collier, Elaine; Hall, Dan; Kaeser, Lisa; Kaufmann, Petra; Krischer, Jeffrey; Livingston, Michelle; McCabe, Linda L.; Pace, Jill; Pfenninger, Karl; Rasmussen, Sonja A.; Reeves, Roger H.; Rubinstein, Yaffa; Sherman, Stephanie; Terry, Sharon F.; Whitten, Michelle Sie; Williams, Stephen; McCabe, Edward R.B.; Maddox, Yvonne T.
2011-01-01
A December 2010 meeting, “Down Syndrome: National Conference on Patient Registries, Research Databases, and Biobanks,” was jointly sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) at the National Institutes of Health (NIH) in Bethesda, MD, and the Global Down Syndrome Foundation (GDSF)/Linda Crnic Institute for Down Syndrome based in Denver, CO. Approximately 70 attendees and organizers from various advocacy groups, federal agencies (Centers for Disease Control and Prevention, and various NIH Institutes, Centers, and Offices), members of industry, clinicians, and researchers from various academic institutions were greeted by Drs. Yvonne Maddox, Deputy Director of NICHD, and Edward McCabe, Executive Director of the Linda Crnic Institute for Down Syndrome. They charged the participants to focus on the separate issues of contact registries, research databases, and biobanks through both podium presentations and breakout session discussions. Among the breakout groups for each of the major sessions, participants were asked to generate responses to questions posed by the organizers concerning these three research resources as they related to Down syndrome and then to report back to the group at large with a summary of their discussions. This report represents a synthesis of the discussions and suggested approaches formulated by the group as a whole. PMID:21835664
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Power to the Pelvis: Strengthening Your Pelvic Floor Muscles
... to Anyone Battling a Bulging Hernia Keeping Your Gut in Check The Power of Your Pancreas Wise ... Kennedy Shriver National Institute of Child Health and Human Development Pelvic Floor Disorders Network. Am J Obstet ...
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Risk Factors for Post-NICU Discharge Mortality Among Extremely Low Birth Weight Infants
De Jesus, Lilia C.; Pappas, Athina; Shankaran, Seetha; Kendrick, Douglas; Das, Abhik; Higgins, Rosemary D.; Bell, Edward F.; Stoll, Barbara J.; Laptook, Abbot R.; Walsh, Michele C.
2012-01-01
Objective To evaluate maternal and neonatal risk factors associated with post-neonatal intensive care unit (NICU) discharge mortality among ELBW infants. Study design This is a retrospective analysis of extremely low birth weight (<1,000 g) and <27 weeks' gestational age infants born in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network sites from January 2000 to June 2007. Infants were tracked until death or 18–22 months corrected age. Infants who died between NICU discharge and the 18–22 month follow-up visit were classified as post-NICU discharge mortality. Association of maternal and infant risk factors with post-NICU discharge mortality was determined using logistic regression analysis. A prediction model with six significant predictors was developed and validated. Results 5,364 infants survived to NICU discharge. 557 (10%) infants were lost to follow-up, and 107 infants died following NICU discharge. Post-NICU discharge mortality rate was 22.3 per 1000 ELBW infants. In the prediction model, African-American race, unknown maternal health insurance, and hospital stay ≥120 days significantly increased risk, and maternal exposure to intra-partum antibiotics was associated with decreased risk of post-NICU discharge mortality. Conclusion We identified African-American race, unknown medical insurance and prolonged NICU stay as risk factors associated with post-NICU discharge mortality among ELBW infants. PMID:22325187
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Down syndrome: national conference on patient registries, research databases, and biobanks.
Oster-Granite, Mary Lou; Parisi, Melissa A; Abbeduto, Leonard; Berlin, Dorit S; Bodine, Cathy; Bynum, Dana; Capone, George; Collier, Elaine; Hall, Dan; Kaeser, Lisa; Kaufmann, Petra; Krischer, Jeffrey; Livingston, Michelle; McCabe, Linda L; Pace, Jill; Pfenninger, Karl; Rasmussen, Sonja A; Reeves, Roger H; Rubinstein, Yaffa; Sherman, Stephanie; Terry, Sharon F; Whitten, Michelle Sie; Williams, Stephen; McCabe, Edward R B; Maddox, Yvonne T
2011-01-01
A December 2010 meeting, "Down Syndrome: National Conference on Patient Registries, Research Databases, and Biobanks," was jointly sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) at the National Institutes of Health (NIH) in Bethesda, MD, and the Global Down Syndrome Foundation (GDSF)/Linda Crnic Institute for Down Syndrome based in Denver, CO. Approximately 70 attendees and organizers from various advocacy groups, federal agencies (Centers for Disease Control and Prevention, and various NIH Institutes, Centers, and Offices), members of industry, clinicians, and researchers from various academic institutions were greeted by Drs. Yvonne Maddox, Deputy Director of NICHD, and Edward McCabe, Executive Director of the Linda Crnic Institute for Down Syndrome. They charged the participants to focus on the separate issues of contact registries, research databases, and biobanks through both podium presentations and breakout session discussions. Among the breakout groups for each of the major sessions, participants were asked to generate responses to questions posed by the organizers concerning these three research resources as they related to Down syndrome and then to report back to the group at large with a summary of their discussions. This report represents a synthesis of the discussions and suggested approaches formulated by the group as a whole. Copyright © 2011. Published by Elsevier Inc. All rights reserved.
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Dunkel Schetter, Christine; Schafer, Peter; Lanzi, Robin Gaines; Clark-Kauffman, Elizabeth; Raju, Tonse N K; Hillemeier, Marianne M
2013-11-01
Health disparities are large and persistent gaps in the rates of disease and death between racial/ethnic and socioeconomic status subgroups in the population. Stress is a major pathway hypothesized to explain such disparities. The Eunice Kennedy Shriver National Institute of Child Health and Human Development formed a community/research collaborative-the Community Child Health Network-to investigate disparities in maternal and child health in five high-risk communities. Using community participation methods, we enrolled a large cohort of African American/Black, Latino/Hispanic, and non-Hispanic/White mothers and fathers of newborns at the time of birth and followed them over 2 years. A majority had household incomes near or below the federal poverty level. Home interviews yielded detailed information regarding multiple types of stress such as major life events and many forms of chronic stress including racism. Several forms of stress varied markedly by racial/ethnic group and income, with decreasing stress as income increased among Caucasians but not among African Americans; other forms of stress varied by race/ethnicity or poverty alone. We conclude that greater sophistication in studying the many forms of stress and community partnership is necessary to uncover the mechanisms underlying health disparities in poor and ethnic-minority families and to implement community health interventions. © The Author(s) 2013.
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Specific etiologies associated with the multiple organ dysfunction syndrome in children: Part 2
Upperman, Jeffrey S.; Bucuvalas, John C.; Williams, Felicia N.; Cairns, Bruce A.; Cox, Charles S.; Doctor, Allan; Tamburro, Robert F.
2016-01-01
Objective To describe a number of conditions and therapies associated with multiple organ dysfunction syndrome (MODS) presented as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development MODS Workshop (March 26–27, 2015). In addition, the relationship between burn injuries and MODS is also included although it was not discussed at the Workshop. Data Sources Literature review, research data, and expert opinion. Study Selection Not applicable. Data Extraction Moderated by an expert from the field, issues relevant to the association of MODS with a variety of conditions and therapies were presented, discussed and debated with a focus on identifying knowledge gaps and research priorities. Data Synthesis Summary of presentations and discussion supported and supplemented by relevant literature. Conclusions Sepsis and trauma are the two conditions most commonly associated with MODS both in children and adults. However, many other pathophysiologic processes may result in MODS. In this paper, we discuss conditions such as liver failure and pancreatitis, pathophysiologic processes such as ischemia and hypoxia, and injuries such as trauma and burns. Additionally, therapeutic interventions such as medications, blood transfusions, transplantation may also precipitate and contribute to MODS. The purpose of this manuscript is to describe the association of MODS with a variety of conditions and therapies in an attempt to identify similarities, differences and opportunities for therapeutic intervention. PMID:28248835
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Cognitive Development One Year After Infantile Critical Pertussis.
Berger, John T; Villalobos, Michele E; Clark, Amy E; Holubkov, Richard; Pollack, Murray M; Berg, Robert A; Carcillo, Joseph A; Dalton, Heidi; Harrison, Rick; Meert, Kathleen L; Newth, Christopher J L; Shanley, Thomas P; Wessel, David L; Anand, Kanwaljeet J S; Zimmerman, Jerry J; Sanders, Ronald C; Liu, Teresa; Burr, Jeri S; Willson, Douglas F; Doctor, Allan; Dean, J Michael; Jenkins, Tammara L; Nicholson, Carol E
2018-02-01
Pertussis can cause life-threatening illness in infants. Data regarding neurodevelopment after pertussis remain scant. The aim of this study was to assess cognitive development of infants with critical pertussis 1 year after PICU discharge. Prospective cohort study. Eight hospitals comprising the Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 18 additional sites across the United States. Eligible patients had laboratory confirmation of pertussis infection, were less than 1 year old, and were admitted to the PICU for at least 24 hours. The Mullen Scales of Early Learning was administered at a 1-year follow-up visit. Functional status was determined by examination and parental interview. Of 196 eligible patients, 111 (57%) completed the Mullen Scales of Early Learning. The mean scores for visual reception, receptive language, and expressive language domains were significantly lower than the norms (p < 0.001), but not fine and gross motor domains. Forty-one patients (37%) had abnormal scores in at least one domain and 10 (9%) had an Early Learning Composite score 2 or more SDs below the population norms. Older age (p < 0.003) and Hispanic ethnicity (p < 0.008) were associated with lower mean Early Learning Composite score, but presenting symptoms and PICU course were not. Infants who survive critical pertussis often have neurodevelopmental deficits. These infants may benefit from routine neurodevelopmental screening.
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Genetics Home Reference: Myhre syndrome
... features of autism spectrum disorder affecting communication and social interaction. Hearing loss occurs in most people with Myhre ... Kennedy Shriver National Institute of Child Health and Human Development: Intellectual and Developmental Disabilities Educational Resources (6 ...
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Genetics Home Reference: Partington syndrome
... of autism spectrum disorders that affect communication and social interaction. Recurrent seizures (epilepsy) may also occur in Partington ... Kennedy Shriver National Institute of Child Health and Human Development: Intellectual and Developmental Disabilities National Institute of ...
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Genetics Home Reference: Down syndrome
... called autism spectrum disorders, which affect communication and social interaction. People with Down syndrome often experience a gradual ... Kennedy Shriver National Institute of Child Health and Human Development GeneEd National Human Genome Research Institute National ...
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HealthLines The Pain Before the Fall | NIH MedlinePlus the Magazine
... the condition than those who drank less than one serving a month. Left untreated, gestational diabetes can cause complications during pregnancy. It also raises the risk of the mother and the baby developing type 2 diabetes later in life. The Eunice Kennedy ...
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. – NASA Kennedy Space Center Director Robert Cabana welcomes community leaders, business executives, educators, community organizers, and state and local government leaders to the Kennedy Space Center Visitor Complex Debus Center for the Kennedy Space Center Director Update. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. – NASA Kennedy Space Center Director Robert Cabana addresses the community leaders, business executives, educators, community organizers, and state and local government leaders attending the Kennedy Space Center Director in the Kennedy Space Center Visitor Complex Debus Center. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. – NASA Kennedy Space Center Director Robert Cabana briefs the community leaders, business executives, educators, community organizers, and state and local government leaders attending the Kennedy Space Center Director in the Kennedy Space Center Visitor Complex Debus Center. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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Survival and morbidity outcomes for very low birth weight infants with Down syndrome.
Boghossian, Nansi S; Hansen, Nellie I; Bell, Edward F; Stoll, Barbara J; Murray, Jeffrey C; Laptook, Abbot R; Shankaran, Seetha; Walsh, Michele C; Das, Abhik; Higgins, Rosemary D
2010-12-01
Our objective was to compare survival and neonatal morbidity rates between very low birth weight (VLBW) infants with Down syndrome (DS) and VLBW infants with non-DS chromosomal anomalies, nonchromosomal birth defects (BDs), and no chromosomal anomaly or major BD. Data were collected prospectively for infants weighing 401 to 1500 g who were born and/or cared for at one of the study centers participating in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network in 1994-2008. Risk of death and morbidities, including patent ductus arteriosus (PDA), necrotizing enterocolitis (NEC), late-onset sepsis (LOS), retinopathy of prematurity, and bronchopulmonary dysplasia (BPD), were compared between VLBW infants with DS and infants in the other groups. Infants with DS were at increased risk of death (adjusted relative risk: 2.47 [95% confidence interval: 2.00-3.07]), PDA, NEC, LOS, and BPD, relative to infants with no BDs. Decreased risk of death (relative risk: 0.40 [95% confidence interval: 0.31-0.52]) and increased risks of NEC and LOS were observed when infants with DS were compared with infants with other non-DS chromosomal anomalies. Relative to infants with nonchromosomal BDs, infants with DS were at increased risk of PDA and NEC. The increased risk of morbidities among VLBW infants with DS provides useful information for counseling parents and for anticipating the need for enhanced surveillance for prevention of these morbidities.
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Sudden Unexpected Death in Fetal Life Through Early Childhood
Kinney, Hannah C.; Willinger, Marian
2016-01-01
In March 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human Development held a workshop entitled “Sudden Unexpected Death in Fetal Life Through Early Childhood: New Opportunities.” Its objective was to advance efforts to understand and ultimately prevent sudden deaths in early life, by considering their pathogenesis as a potential continuum with some commonalities in biological origins or pathways. A second objective of this meeting was to highlight current issues surrounding the classification of sudden infant death syndrome (SIDS), and the implications of variations in the use of the term “SIDS” in forensic practice, and pediatric care and research. The proceedings reflected the most current knowledge and understanding of the origins and biology of vulnerability to sudden unexpected death, and its environmental triggers. Participants were encouraged to consider the application of new technologies and “omics” approaches to accelerate research. The major advances in delineating the intrinsic vulnerabilities to sudden death in early life have come from epidemiologic, neural, cardiac, metabolic, genetic, and physiologic research, with some commonalities among cases of unexplained stillbirth, SIDS, and sudden unexplained death in childhood observed. It was emphasized that investigations of sudden unexpected death are inconsistent, varying by jurisdiction, as are the education, certification practices, and experience of death certifiers. In addition, there is no practical consensus on the use of “SIDS” as a determination in cause of death. Major clinical, forensic, and scientific areas are identified for future research. PMID:27230764
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Specific Etiologies Associated With the Multiple Organ Dysfunction Syndrome in Children: Part 2.
Upperman, Jeffrey S; Bucuvalas, John C; Williams, Felicia N; Cairns, Bruce A; Cox, Charles S; Doctor, Allan; Tamburro, Robert F
2017-03-01
To describe a number of conditions and therapies associated with multiple organ dysfunction syndrome presented as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Multiple Organ Dysfunction Workshop (March 26-27, 2015). In addition, the relationship between burn injuries and multiple organ dysfunction syndrome is also included although it was not discussed at the workshop. Literature review, research data, and expert opinion. Not applicable. Moderated by an expert from the field, issues relevant to the association of multiple organ dysfunction syndrome with a variety of conditions and therapies were presented, discussed, and debated with a focus on identifying knowledge gaps and the research priorities. Summary of presentations and discussion supported and supplemented by relevant literature. Sepsis and trauma are the two conditions most commonly associated with multiple organ dysfunction syndrome both in children and adults. However, many other pathophysiologic processes may result in multiple organ dysfunction syndrome. In this article, we discuss conditions such as liver failure and pancreatitis, pathophysiologic processes such as ischemia and hypoxia, and injuries such as trauma and burns. Additionally, therapeutic interventions such as medications, blood transfusions, transplantation may also precipitate and contribute to multiple organ dysfunction syndrome. The purpose of this article is to describe the association of multiple organ dysfunction syndrome with a variety of conditions and therapies in an attempt to identify similarities, differences, and opportunities for therapeutic intervention.
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Pediatric Multiple Organ Dysfunction Syndrome: Promising Therapies.
Doctor, Allan; Zimmerman, Jerry; Agus, Michael; Rajasekaran, Surender; Bubeck Wardenburg, Juliane; Fortenberry, James; Zajicek, Anne; Mairson, Emma; Typpo, Katri
2017-03-01
To describe the state of the science, identify knowledge gaps, and offer potential future research questions regarding promising therapies for children with multiple organ dysfunction syndrome presented during the Eunice Kennedy Shriver National Institute of Child Health and Human Development Workshop on Pediatric Multiple Organ Dysfunction Syndrome (March 26-27, 2015). Literature review, research data, and expert opinion. Not applicable. Moderated by an expert from the field, issues relevant to the association of multiple organ dysfunction syndrome with a variety of conditions were presented, discussed, and debated with a focus on identifying knowledge gaps and research priorities. Summary of presentations and discussion supported and supplemented by relevant literature. Among critically ill children, multiple organ dysfunction syndrome is relatively common and associated with significant morbidity and mortality. For outcomes to improve, effective therapies aimed at preventing and treating this condition must be discovered and rigorously evaluated. In this article, a number of potential opportunities to enhance current care are highlighted including the need for a better understanding of the pharmacokinetics and pharmacodynamics of medications, the effect of early and optimized nutrition, and the impact of effective glucose control in the setting of multiple organ dysfunction syndrome. Additionally, a handful of the promising therapies either currently being implemented or developed are described. These include extracorporeal therapies, anticytokine therapies, antitoxin treatments, antioxidant approaches, and multiple forms of exogenous steroids. For the field to advance, promising therapies and other therapies must be assessed in rigorous manner and implemented accordingly.
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Development of a Pediatric Adverse Events Terminology
Gipson, Debbie S.; Kirkendall, Eric S.; Gumbs-Petty, Brenda; Quinn, Theresa; Steen, A.; Hicks, Amanda; McMahon, Ann; Nicholas, Savian; Zhao-Wong, Anna; Taylor-Zapata, Perdita; Turner, Mark; Herreshoff, Emily; Jones, Charlotte; Davis, Jonathan M.; Haber, Margaret; Hirschfeld, Steven
2017-01-01
In 2009, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) established the Pediatric Terminology Harmonization Initiative to establish a core library of terms to facilitate the acquisition and sharing of knowledge between pediatric clinical research, practice, and safety reporting. A coalition of partners established a Pediatric Terminology Adverse Event Working Group in 2013 to develop a specific terminology relevant to international pediatric adverse event (AE) reporting. Pediatric specialists with backgrounds in clinical care, research, safety reporting, or informatics, supported by biomedical terminology experts from the National Cancer Institute’s Enterprise Vocabulary Services participated. The multinational group developed a working definition of AEs and reviewed concepts (terms, synonyms, and definitions) from 16 pediatric clinical domains. The resulting AE terminology contains >1000 pediatric diseases, disorders, or clinical findings. The terms were tested for proof of concept use in 2 different settings: hospital readmissions and the NICU. The advantages of the AE terminology include ease of adoption due to integration with well-established and internationally accepted biomedical terminologies, a uniquely temporal focus on pediatric health and disease from conception through adolescence, and terms that could be used in both well- and underresourced environments. The AE terminology is available for use without restriction through the National Cancer Institute’s Enterprise Vocabulary Services and is fully compatible with, and represented in, the Medical Dictionary for Regulatory Activities. The terminology is intended to mature with use, user feedback, and optimization. PMID:28028203
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Development of a Pediatric Adverse Events Terminology.
Gipson, Debbie S; Kirkendall, Eric S; Gumbs-Petty, Brenda; Quinn, Theresa; Steen, A; Hicks, Amanda; McMahon, Ann; Nicholas, Savian; Zhao-Wong, Anna; Taylor-Zapata, Perdita; Turner, Mark; Herreshoff, Emily; Jones, Charlotte; Davis, Jonathan M; Haber, Margaret; Hirschfeld, Steven
2017-01-01
In 2009, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) established the Pediatric Terminology Harmonization Initiative to establish a core library of terms to facilitate the acquisition and sharing of knowledge between pediatric clinical research, practice, and safety reporting. A coalition of partners established a Pediatric Terminology Adverse Event Working Group in 2013 to develop a specific terminology relevant to international pediatric adverse event (AE) reporting. Pediatric specialists with backgrounds in clinical care, research, safety reporting, or informatics, supported by biomedical terminology experts from the National Cancer Institute's Enterprise Vocabulary Services participated. The multinational group developed a working definition of AEs and reviewed concepts (terms, synonyms, and definitions) from 16 pediatric clinical domains. The resulting AE terminology contains >1000 pediatric diseases, disorders, or clinical findings. The terms were tested for proof of concept use in 2 different settings: hospital readmissions and the NICU. The advantages of the AE terminology include ease of adoption due to integration with well-established and internationally accepted biomedical terminologies, a uniquely temporal focus on pediatric health and disease from conception through adolescence, and terms that could be used in both well- and underresourced environments. The AE terminology is available for use without restriction through the National Cancer Institute's Enterprise Vocabulary Services and is fully compatible with, and represented in, the Medical Dictionary for Regulatory Activities. The terminology is intended to mature with use, user feedback, and optimization. Copyright © 2017 by the American Academy of Pediatrics.
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. - NASA Kennedy Space Center Director Robert Cabana, second from right, welcomes community leaders, business executives, educators, community organizers, and state and local government leaders to the Kennedy Space Center Visitor Complex Debus Center for the Kennedy Space Center Director Update. At far right is Brevard County District 1 Commissioner Robin Fisher. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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2013-05-20
Journalist and former First Lady of California Maria Shriver reads the poem "The Summer Day" by Mary Oliver during the National Tribute to Sally Ride at the John F. Kennedy Center for the Performing Arts, Monday, May 20, 2013 in Washington. Photo Credit: (NASA/Bill Ingalls)
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. An attendee talks with Scott Thurston, Kennedy deputy of the spacecraft office at the Commercial Crew Program display. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. From left, Scott Thurston, Kennedy deputy of the spacecraft office of the Commercial Crew Program, talks with Scott Colloredo, director of the Center Planning and Development Directorate. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. Attendees talk with Trey Carlson, Kennedy Master Planner, at the Center Planning and Development Directorate, or CPDD, display. In the background is Mario Busacca, chief of CPDD’s Spaceport Planning Office. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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2013-05-20
Journalist and former First Lady of California Maria Shriver talks prior to reading the poem "The Summer Day" by Mary Oliver during the National Tribute to Sally Ride at the John F. Kennedy Center for the Performing Arts, Monday, May 20, 2013 in Washington. Photo Credit: (NASA/Bill Ingalls)
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during KSC Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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The Kennedy Myth and American Politics.
ERIC Educational Resources Information Center
Parmet, Herbert S.
1990-01-01
Examines the John F. Kennedy legend and his ability as an image maker. Characterizes Kennedy's presidency in terms of pragmatic idealism. Says Kennedy and Lyndon B. Johnson closed out the New and Fair Deal reforms but left no social or economic transformation. Claims Kennedy's disavowal of ideological rigidity ended the power of the Democratic…
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. Rob Mueller, senior technologist, talks with attendees at the Swamp Works display. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. Rob Mueller, a senior technologist, talks to an attendee about Kennedy’s Swamp Works Laboratory. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. At left, Susan Fernandez from the Office of Senator Marco Rubio talks with another attendee near the Education display. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. Attendees mingled and visited various displays, including Ground Systems Development and Operations Program and Education Office displays. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. An attendee talks with engineers Jason Hopkins and Lisa Lutz, at the Ground Systems Development and Operations display. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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Kennedy Space Center Director Update
2014-03-06
CAPE CANAVERAL, Fla. - Community leaders, business executives, educators, and state and local government leaders were updated on NASA Kennedy Space Center programs and accomplishments during Center Director Bob Cabana’s Center Director Update at the Debus Center at the Kennedy Space Center Visitor Complex in Florida. An attendee talks with Trent Smith, program manager, and Tammy Belk, a program specialist, at the ISS Ground Processing and Research Office display. Attendees talked with Cabana and other senior Kennedy managers and visited displays featuring updates on Kennedy programs and projects, including International Space Station, Commercial Crew, Ground System Development and Operations, Launch Services, Center Planning and Development, Technology, KSC Swamp Works and NASA Education. The morning concluded with a tour of the new Space Shuttle Atlantis exhibit at the visitor complex. For more information, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Daniel Casper
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Obama Kennedy Space Center Visit
2010-04-14
NASA Deputy Administrator Lori Garver shakes hands with President Barack Obama as she and NASA Kennedy Space Center Director Bob Cabana, left, welcome the President to Kennedy in Cape Canaveral, Fla. on Thursday, April 15, 2010. Obama visited Kennedy to deliver remarks on the bold new course the administration is charting to maintain U.S. leadership in human space flight. Photo Credit: (NASA/Bill Ingalls)
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Obama Kennedy Space Center Visit
2010-04-14
NASA Kennedy Space Center Director bob Cabana shakes hands with President Barack Obama as he and Gen. C. Robert Kehler, Commander, Air Force Space Command, left, welcome the President to Kennedy in Cape Canaveral, Fla. on Thursday, April 15, 2010. Obama visited Kennedy to deliver remarks on the bold new course the administration is charting to maintain U.S. leadership in human space flight. Photo Credit: (NASA/Bill Ingalls)
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Seungdamrong, Aimee; Steiner, Anne Z; Gracia, Clarisa R; Legro, Richard S; Diamond, Michael P; Coutifaris, Christos; Schlaff, William D; Casson, Peter; Christman, Gregory M; Robinson, Randal D; Huang, Hao; Alvero, Ruben; Hansen, Karl R; Jin, Susan; Eisenberg, Esther; Zhang, Heping; Santoro, Nanette
2017-10-25
To study whether preconceptual thyroid-stimulating hormone (TSH) and antithyroid peroxidase (TPO) antibodies are associated with poor reproductive outcomes in infertile women. Secondary analysis of data from two multicenter, randomized, controlled trials conducted by the Reproductive Medicine Network of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Multivariable logistic regression analyses were performed to assess the association between preconceptual TSH levels and anti-TPO antibodies. Not applicable. Serum samples from 1,468 infertile women were utilized. None. Cumulative conception, clinical pregnancy, miscarriage, and live birth rates were calculated. Conception, clinical pregnancy, miscarriage, and live birth rates did not differ between patients with TSH ≥2.5 mIU/L vs. TSH < 2.5 mIU/L. Women with anti-TPO antibodies had similar conception rates (33.3% vs. 36.3%) but higher miscarriage rates (43.9% vs. 25.3%) and lower live birth rates (17.1% vs. 25.4%) than those without anti-TPO antibodies. Adjusted, multivariable logistic regression models confirmed elevated odds of miscarriage (odds ratio 2.17, 95% confidence interval 1.12-4.22) and lower odds of live birth (oddr ratio 0.58, 95% confidence interval 0.35-0.96) in patients with anti-TPO antibodies. In infertile women, preconceptional TSH ≥2.5 mIU/L is not associated with adverse reproductive outcomes; however, anti-TPO antibodies are associated with increased risk of miscarriage and decreased probability of live birth. PPCOS II NCT00719186; AMIGOS NCT01044862. Copyright © 2017. Published by Elsevier Inc.
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Proposed diagnostic criteria for the case definition of amniotic fluid embolism in research studies
Clark, Steven L.; Romero, Roberto; Dildy, Gary A.; Callaghan, William M.; Smiley, Richard M.; Bracey, Arthur W.; Hankins, Gary D.; D’Alton, Mary E.; Foley, Mike; Pacheco, Luis D.; Vadhera, Rakesh B.; Herlihy, J. Patrick; Berkowitz, Richard L.; Belfort, Michael A.
2016-01-01
Amniotic fluid embolism is a leading cause of maternal mortality in developed countries. Our understanding of risk factors, diagnosis, treatment, and prognosis is hampered by a lack of uniform clinical case definition; neither histologic nor laboratory findings have been identified unique to this condition. Amniotic fluid embolism is often overdiagnosed in critically ill peripartum women, particularly when an element of coagulopathy is involved. Previously proposed case definitions for amniotic fluid embolism are nonspecific, and when viewed through the eyes of individuals with experience in critical care obstetrics, would include women with a number of medical conditions much more common than amniotic fluid embolism. We convened a working group under the auspices of a committee of the Society for Maternal-Fetal Medicine and the Amniotic Fluid Embolism Foundation whose task was to develop uniform diagnostic criteria for the research reporting of amniotic fluid embolism. These criteria rely on the presence of the classic triad of hemodynamic and respiratory compromise accompanied by strictly defined disseminated intravascular coagulopathy. It is anticipated that limiting research reports involving amniotic fluid embolism to women who meet these criteria will enhance the validity of published data and assist in the identification of risk factors, effective treatments, and possibly useful biomarkers for this condition. A registry has been established in conjunction with the Perinatal Research Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development to collect both clinical information and laboratory specimens of women with suspected amniotic fluid embolism in the hopes of identifying unique biomarkers of this condition. PMID:27372270
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Pathophysiology of the gut and the microbiome in the host response
Lyons, John D.; Coopersmith, Craig M.
2016-01-01
Objective To describe and summarize the data supporting the “gut” as the motor driving critical illness and multiple organ dysfunction syndrome (MODS) presented at the Eunice Kennedy Shriver National Institute of Child Health and Human Development MODS Workshop (March 26–27, 2015). Data Sources Summary of workshop keynote presentation. Study Selection Not applicable. Data Extraction Presented by an expert in the field, the data assessing the role of gastrointestinal dysfunction driving critical illness were described with a focus on identifying knowledge gaps and research priorities. Data Synthesis Summary of presentation and discussion supported and supplemented by relevant literature. Conclusions The understanding of gut dysfunction in critical illness has evolved greatly over time, and the gut is now often considered as the “motor” of critical illness. The association of the gut with critical illness is supported by both animal models and clinical studies. Initially, the association between gut dysfunction and critical illness focused primarily on bacterial translocation into the bloodstream. However, that work has evolved to include other gut-derived products causing distant injury via other routes (e.g. lymphatics). Additionally, alterations in the gut epithelium may be associated with critical illness and influence outcomes. Gut epithelial apoptosis, intestinal hyperpermeability and perturbations in the intestinal mucus layer have all been associated with critical illness. Finally, there is growing evidence that the intestinal microbiome plays a crucial role in mediating pathology in critical illness. Further research is needed to better understand the role of each of these mechanisms and their contribution to MODS in children. PMID:28248833
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Impact of timing of birth and resident duty-hour restrictions on outcomes for small preterm infants.
Bell, Edward F; Hansen, Nellie I; Morriss, Frank H; Stoll, Barbara J; Ambalavanan, Namasivayam; Gould, Jeffrey B; Laptook, Abbot R; Walsh, Michele C; Carlo, Waldemar A; Shankaran, Seetha; Das, Abhik; Higgins, Rosemary D
2010-08-01
The goal was to examine the impact of birth at night, on the weekend, and during July or August (the first months of the academic year) and the impact of resident duty-hour restrictions on mortality and morbidity rates for very low birth weight infants. Outcomes were analyzed for 11,137 infants with birth weights of 501 to 1250 g who were enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network registry in 2001-2005. Approximately one-half were born before the introduction of resident duty-hour restrictions in 2003. Follow-up assessments at 18 to 22 months were completed for 4508 infants. Mortality rate, short-term morbidities, and neurodevelopmental outcome were examined with respect to the timing of birth. There was no effect of the timing of birth on mortality rate and no impact on the risks of short-term morbidities except that the risk of retinopathy of prematurity (stage > or =2) was higher after the introduction of duty-hour restrictions and the risk of retinopathy of prematurity requiring operative treatment was lower for infants born during the late night than during the day. There was no impact of the timing of birth on neurodevelopmental outcome except that the risk of hearing impairment or death was slightly lower among infants born in July or August. In this network, the timing of birth had little effect on the risks of death and morbidity for very low birth weight infants, which suggests that staffing patterns were adequate to provide consistent care.
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Lowe, Jean R.; Duncan, Andrea Freeman; Bann, Carla M.; Fuller, Janell; Hintz, Susan R.; Das, Abhik; Higgins, Rosemary D.; Watterberg, Kristi L.
2013-01-01
Background Difficulties with executive function has been found in preterm children, resulting in difficulties with learning and school performance. Aim This study evaluated the relationship of early working memory as measured by object permanence items to the cognitive and language scores on the Bayley Scales-III in a cohort of children born extremely preterm. Study Design Logistic regression models were conducted to compare object permanence scores derived from the Bayley Scales-III by race/ethnicity and maternal education, controlling for medical covariates. Subjects Extremely preterm toddlers (526), who were part of a Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's multi-center study, were evaluated at 18-22 months corrected age. Outcome Measures Object permanence scores derived from the Bayley Developmental Scales were compared by race/ethnicity and maternal education, controlling for medical covariates. Results There were no significant differences in object permanence mastery and scores among the treatment groups after controlling for medical and social variables, including maternal education and race/ethnicity. Males and children with intraventricular hemorrhage, retinopathy of prematurity, and bronchopulmonary dysplasia were less likely to demonstrate object permanence mastery and had lower object permanence scores. Children who attained object permanence mastery had significantly higher Bayley Scales-III cognitive and language scores after controlling for medical and socio-economic factors. Conclusions Our measure of object permanence is free of influence from race, ethnic and socio-economic factors. Adding this simple task to current clinical practice could help detect early executive function difficulties in young children. PMID:23993309
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Lowe, Jean R; Duncan, Andrea Freeman; Bann, Carla M; Fuller, Janell; Hintz, Susan R; Das, Abhik; Higgins, Rosemary D; Watterberg, Kristi L
2013-12-01
Difficulties with executive function have been found in preterm children, resulting in difficulties with learning and school performance. This study evaluated the relationship of early working memory as measured by object permanence items to the cognitive and language scores on the Bayley Scales-III in a cohort of children born extremely preterm. Logistic regression models were conducted to compare object permanence scores derived from the Bayley Scales-III by race/ethnicity and maternal education, controlling for medical covariates. Extremely preterm toddlers (526), who were part of a Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's multi-center study, were evaluated at 18-22 months corrected age. Object permanence scores derived from the Bayley Developmental Scales were compared by race/ethnicity and maternal education, controlling for medical covariates. There were no significant differences in object permanence mastery and scores among the treatment groups after controlling for medical and social variables, including maternal education and race/ethnicity. Males and children with intraventricular hemorrhage, retinopathy of prematurity, and bronchopulmonary dysplasia were less likely to demonstrate object permanence mastery and had lower object permanence scores. Children who attained object permanence mastery had significantly higher Bayley Scales-III cognitive and language scores after controlling for medical and socio-economic factors. Our measure of object permanence is free of influence from race, ethnic and socio-economic factors. Adding this simple task to current clinical practice could help detect early executive function difficulties in young children. Published by Elsevier Ireland Ltd.
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Pipeline for Contraceptive Development
Blithe, Diana L.
2016-01-01
The high rates of unplanned pregnancy reflect unmet need for effective contraceptive methods for women, especially for individuals with health risks such as obesity, diabetes, hypertension, and other conditions that may contraindicate use of an estrogen-containing product. Improvements in safety, user convenience, acceptability and availability of products remain important goals of the contraceptive development program. Another important goal is to minimize the impact of the products on the environment. Development of new methods for male contraception has the potential to address many of these issues with regard to safety for women who have contraindications to effective contraceptive methods but want to protect against pregnancy. It also will address a huge unmet need for men who want to control their fertility. Products under development for men would not introduce eco-toxic hormones in the waste water. Investment in contraceptive research to identify new products for women has been limited in the pharmaceutical industry relative to investment in drug development for other indications. Pharmaceutical R&D for male contraception was active in the 1990’s but was abandoned over a decade ago. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) has supported a contraceptive development program since 1969. Through a variety of programs including research grants and contracts, NICHD has developed a pipeline of new targets/products for male and female contraception. A number of lead candidates are under evaluation in the NICHD Contraceptive Clinical Trials Network (CCTN) (1–3). PMID:27523300
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Pediatric Multiple Organ Dysfunction Syndrome: Promising Therapies
Doctor, Allan; Zimmerman, Jerry; Agus, Michael; Rajasekaran, Surender; Wardenburg, Juliane Bubeck; Fortenberry, James; Zajicek, Anne; Typpo, Katri
2016-01-01
Objective To describe the state of the science, identify knowledge gaps, and offer potential future research questions regarding promising therapies for children with multiple organ dysfunction syndrome (MODS) presented during the Eunice Kennedy Shriver National Institute of Child Health and Human Development Workshop on Pediatric Multiple Organ Dysfunction Syndrome (March 26-27, 2015). Data Sources Literature review, research data, and expert opinion. Study Selection Not applicable. Data Extraction Moderated by an expert from the field, issues relevant to the association of MODS with a variety of conditions were presented, discussed and debated with a focus on identifying knowledge gaps and research priorities. Data Synthesis Summary of presentations and discussion supported and supplemented by relevant literature. Conclusions Among critically ill children, MODS is relatively common and associated with significant morbidity and mortality. For outcomes to improve, effective therapies aimed at preventing and treating this condition must be discovered and rigorously evaluated. In this manuscript, a number of potential opportunities to enhance current care are highlighted including the need for a better understanding of the pharmacokinetics and pharmacodynamics of medications, the effect of early and optimized nutrition, and the impact of effective glucose control in the setting of MODS. Additionally, a handful of the promising therapies either currently being implemented or developed are described. These include extracorporeal therapies, anti-cytokine therapies, anti-toxin treatments, anti-oxidant approaches and multiple forms of exogenous steroids. For the field to advance, these and other therapies must be assessed in rigorous manner and implemented accordingly. PMID:28248836
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Child Intellectual Development in Relation to Cytokine Levels in Umbilical Cord Blood
von Ehrenstein, Ondine S.; Neta, Gila I.; Andrews, William; Goldenberg, Robert; Goepfert, Alice; Zhang, Jun
2012-01-01
Although cytokines play a dual role in the developing neurologic system and in prenatal immune reactions, relations between fetal cytokine levels and child intellectual development remain unknown. The authors investigated associations between umbilical cord serum cytokine concentrations and intellectual outcomes in 369 children within a prospective cohort study, the Eunice Kennedy Shriver National Institute of Child Health and Human Development-University of Alabama Infant Growth Study (1985–1988). Concentrations of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and interleukins 4, 10, and 12p70 were determined. The Wechsler Preschool and Primary Scale of Intelligence–Revised was administered at age 5 years, producing verbal and performance intelligence quotients (VIQ and PIQ); associations with each cytokine were evaluated using linear and logistic regression. Log-unit increases in IFN-γ (adjusted odds ratio (aOR) = 0.67, 95% confidence interval (CI): 0.46, 0.98) and interleukin-12p70 (aOR = 0.43, 95% CI: 0.21, 0.87) were inversely associated with low PIQ (score <70). One log-unit increase in TNF-α was associated with a reduced odds ratio for low VIQ (score <70) among preterm children (aOR = 0.11, 95% CI: 0.01, 0.94) and an elevated odds ratio for low VIQ among small-for-gestational-age children (aOR = 3.96, 95% CI: 0.99, 15.9). IFN-γ, which is involved in neurogenesis and perinatal adaptive immunity, may be related to fetal neurologic development overall, while TNF-α may be a marker of intellectual development in vulnerable subgroups. PMID:22508393
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Maume, David J
2017-08-01
The goal of this study was to assess the bi-directional effects of sleep and health (body mass index [BMI], depression, and substance use) among adolescents in the presence of comprehensive controls for social relationships and daily stressors and supports. Longitudinal survey. Data were obtained from the Study of Early Child Care and Youth Development, a longitudinal survey designed and administered by the Eunice Kennedy Shriver National Institute of Child Health and Human Development. At total of 974 adolescents ages 12-15; 50% girls. Total sleep time was derived from difference between usual bedtime and arise time; youths self-reported the frequency of using alcohol, tobacco, and marijuana, and most of the predictors of sleep-health (e.g., parental monitoring, school and peer attachment); youth's body mass index and physical development (i.e., Tanner stage score) were assessed in clinics. Teen sleep duration declined and health deteriorated from age 12-15, but results from a 2-stage least squares analysis showed and that sleep duration was among the strongest predictors of teen health; by contrast, BMI, depression, and substance use had no effect on sleep duration. Youth sleep and health were both determined by changes in family structure, income, parental monitoring, school and peer attachment, time spent in homework and on the computer, and physical development (health only). The constellation of teens' social ties and daily stressors affects the sleep-health nexus, and future studies should account for this complexity and diversity of teens' lives. Copyright © 2017 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.
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Human Spaceflight The Kennedy Legacy
2011-05-25
Musician Herbie Hancock bows to the audience after perfrorming during a program commemorating Human Spaceflight and the Kennedy Legacy, Wednesday, May 25, 2011, in the concert hall at the John F. Kennedy Center for the Performing Arts in Washington. The event marked the 50th Anniversary of President John F. Kennedy's Special Message to the Congress on Urgent National Needs in which he stated "landing a man on the moon and returning him safely to earth". Photo Credit: (NASA/Paul E. Alers)
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Human Spaceflight The Kennedy Legacy
2011-05-25
Musician Herbie Hancock plays a piece on the piano during a program commemorating Human Spaceflight and the Kennedy Legacy, Wednesday, May 25, 2011, in the concert hall at the John F. Kennedy Center for the Performing Arts in Washington. The event marked the 50th Anniversary of President John F. Kennedy's Special Message to the Congress on Urgent National Needs in which he stated "landing a man on the moon and returning him safely to earth". Photo Credit: (NASA/Paul E. Alers)
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Obama Kennedy Space Center Visit
2010-04-14
Gen. C. Robert Kehler, Commander, Air Force Space Command, left, NASA Deputy Administrator Lori Garver, 2nd from left, NASA Kennedy Space Center Director Bob Cabana, and Col. Burke E. Wilson is the Commander, 45th Space Wing, right, welcome the arrival of Air Force One and President Barack Obama to the NASA Kennedy Space Center in Cape Canaveral, Fla. on Thursday, April 15, 2010. Obama visited Kennedy to deliver remarks on the bold new course the administration is charting to maintain U.S. leadership in human space flight. Photo Credit: (NASA/Bill Ingalls)
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Obama Kennedy Space Center Visit
2010-04-14
President Barack Obama waves farewell after speaking at the NASA Kennedy Space Center in Cape Canaveral, Fla. on Thursday, April 15, 2010. Obama visited Kennedy to deliver remarks on the bold new course the administration is charting to maintain U.S. leadership in human space flight. Photo Credit: (NASA/Bill Ingalls)
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2003-10-15
KENNEDY SPACE CENTER, FLA. - Astronaut Barry E. Wilmore (left) and Center Director Jim Kennedy pose for a photo after Wilmore presented Kennedy with a special award for Spaceport Super Safety and Health Day.
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2008-05-03
CAPE CANAVERAL, Fla. -- The new inductees into the U.S. Astronaut Hall of Fame stand for an ovation during the ceremony May 3 at NASA's Kennedy Space Center. From left are Loren Shriver; Bryan O'Connor, NASA's chief of Safety and Mission Assurance at NASA Headquarters in Washington; John Blaha; and Robert Cabana, center director of NASA's Stennis Space Center in Mississippi. Other former astronauts attending included Scott Carpenter, John Young, Bob Crippen, and Walt Cunningham. The U.S. Astronaut Hall of Fame is operated by Kennedy Space Center Visitor Complex on behalf of NASA. CNN correspondent John Zarrella hosted the event.
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2009-05-02
CAPE CANAVERAL, Fla. –– Hall of Fame astronauts (from left) Gordon Fullerton, Henry W. "Hank" Hartsfield Jr., Rick Hauk, Dan Brandenstein, Brewster Shaw, Robert "Hoot" Gibson, Bruce McCandless, Steven Hawley, Loren Shriver, Jeff Hoffman, Fred Gregory, John Blaha and Bob Cabana watch the U.S. Astronaut Hall of Fame induction ceremony at NASA's Kennedy Space Center Visitor Complex in Florida. Cabana is the Kennedy Space Center director. The ceremony took place May 2. More than 20 hall of fame astronauts attended, including Scott Carpenter, Walt Cunningham, Jim Lovell and Bob Crippen. Photo credit: NASA/Jim Grossmann
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Obama Kennedy Space Center Visit
2010-04-14
President Barack Obama waves hello as he exits of Air Force One along with Senator Bill Nelson after landing at the NASA Kennedy Space Center in Cape Canaveral, Fla. on Thursday, April 15, 2010. Obama visited Kennedy to deliver remarks on the bold new course the administration is charting to maintain U.S. leadership in human space flight. Photo Credit: (NASA/Bill Ingalls)
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Obama Kennedy Space Center Visit
2010-04-14
President Barack Obama delivers a speech at the Operations and Checkout Building at NASA Kennedy Space Center in Cape Canaveral, Fla. on Thursday, April 15, 2010. Obama visited Kennedy Space Center to deliver remarks on the bold new course the Administration is charting for NASA and the future of U.S. leadership in human space flight. Photo Credit: (NASA/Bill Ingalls)
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Obama Kennedy Space Center Visit
2010-04-14
President Barack Obama delivers a speech at the Operations and Checkout Building at NASA Kennedy Space Center in Cape Canaveral, Fla. on Thursday, April 15, 2010. Obama visited Kennedy Space Center to deliver remarks on the bold new course the Administration is charting for NASA and the future of U.S. leadership in human space flight. Photo Credit: (NASA/Paul E. Alers)
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Postpartum weight retention risk factors and relationship to obesity at 1 year.
Endres, Loraine K; Straub, Heather; McKinney, Chelsea; Plunkett, Beth; Minkovitz, Cynthia S; Schetter, Chris D; Ramey, Sharon; Wang, Chi; Hobel, Calvin; Raju, Tonse; Shalowitz, Madeleine U
2015-01-01
To explore risk factors for postpartum weight retention at 1 year after delivery in predominantly low-income women. Data were collected from 774 women with complete height and weight information from participants in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Community Child Health Network, a national five-site, prospective cohort study. Participants were enrolled primarily in the hospitals immediately after delivery. Maternal interviews conducted at 1, 6, and 12 months postpartum identified risk factors for weight retention and included direct measurement of height and weight at 6 and 12 months. Logistic regression assessed the independent contribution of postpartum weight retention on obesity. Women had a mean prepregnancy weight of 161.5 lbs (body mass index [BMI] 27.7). Women gained a mean of 32 lbs while pregnant and had a 1-year mean postpartum weight of 172.6 lbs (BMI 29.4). Approximately 75% of women were heavier 1 year postpartum than they were prepregnancy, including 47.4% retaining more than 10 lbs and 24.2% more than 20 lbs. Women retaining at least 20 lbs were more often African American, younger, poor, less educated, or on pubic insurance. Race and socioeconomic disparities were associated with high prepregnancy BMI and excessive weight gain during pregnancy, associations that were attenuated by breastfeeding at 6 months and moderate exercise. Of the 39.8 with normal prepregnancy BMI, one third became overweight or obese 1 year postpartum. Postpartum weight retention is a significant contributor to the risk for obesity 1 year postpartum, including for women of normal weight prepregnancy. Postpartum, potentially modifiable behaviors may lower the risk. III.
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Executive summary—Biomarkers of Nutrition for Development: Building a Consensus123
Namasté, Sorrel; Brabin, Bernard; Combs, Gerald; L'Abbe, Mary R; Wasantwisut, Emorn; Darnton-Hill, Ian
2011-01-01
The ability to develop evidence-based clinical guidance and effective programs and policies to achieve global health promotion and disease prevention goals depends on the availability of valid and reliable data. With specific regard to the role of food and nutrition in achieving those goals, relevant data are developed with the use of biomarkers that reflect nutrient exposure, status, and functional effect. A need exists to promote the discovery, development, and use of biomarkers across a range of applications. In addition, a process is needed to harmonize the global health community's decision making about what biomarkers are best suited for a given use under specific conditions and settings. To address these needs, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, organized a conference entitled “Biomarkers of Nutrition for Development: Building a Consensus,” which was hosted by the International Atomic Energy Agency. Partners included key multilateral, US agencies and public and private organizations. The assembly endorsed the utility of this initiative and the need for the BOND (Biomarkers of Nutrition for Development) project to continue. A consensus was reached on the requirement to develop a process to inform the community about the relative strengths or weaknesses and specific applications of various biomarkers under defined conditions. The articles in this supplement summarize the deliberations of the 4 working groups: research, clinical, policy, and programmatic. Also described are content presentations on the harmonization processes, the evidence base for biomarkers for 5 case-study micronutrients, and new frontiers in science and technology. PMID:21733880
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Intranasal carbetocin reduces hyperphagia in individuals with Prader-Willi syndrome.
Dykens, Elisabeth M; Miller, Jennifer; Angulo, Moris; Roof, Elizabeth; Reidy, Michael; Hatoum, Hind T; Willey, Richard; Bolton, Guy; Korner, Paul
2018-06-21
Prader-Willi syndrome (PWS) is a genetic neurodevelopmental disorder of life-threatening hyperphagia, obesity, intellectual deficits, compulsivity, and other behavioral problems. The efficacy and safety of i.n. carbetocin, an oxytocin analog, was evaluated in a prospective, randomized, double-blinded trial in adolescents with PWS. Eligible patients aged 10-18 years with genetically confirmed PWS were randomized (1:1) to i.n. carbetocin or placebo 3 times daily for 14 days. The primary efficacy endpoint was change in parent/caregiver-rated Hyperphagia in PWS Questionnaire-Responsiveness (HPWSQ-R) total score. Secondary efficacy endpoints included HPWSQ-R behavior, drive, and severity domains; clinician-rated HPWSQ; Children's Yale-Brown Obsessive-Compulsive Severity Scale; food domain of the Reiss Profile; and Clinical Global Impression-Improvement scale. Endpoints were assessed using analysis of covariance. Relationship between primary and secondary endpoints was assessed using Pearson correlation coefficients. Safety was assessed throughout the study. Demographics and clinical characteristics were similar between treatment groups (carbetocin, n = 17; placebo, n = 20). Patients receiving carbetocin had statistically significant reductions in HPWSQ-R total score at study end (-15.6) versus patients receiving placebo (-8.9; P = 0.029); several secondary efficacy endpoints also demonstrated significant differences (P < 0.05). Treatment effects for the primary and secondary endpoints were highly correlated (P ≤ 0.0001). Incidence of adverse events (AEs) was similar between treatment groups. I.n. carbetocin was well tolerated and improved hyperphagia and behavioral symptoms of PWS. ClinicalTrials.gov: NCT01968187FUNDING. The study was funded by Ferring Pharmaceuticals. Recruitment was aided by ongoing work in PWS performed through Eunice Kennedy Shriver National Institute of Child Health and Human Development grant U54 HD083211.
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Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility.
Diamond, Michael P; Legro, Richard S; Coutifaris, Christos; Alvero, Ruben; Robinson, Randal D; Casson, Peter A; Christman, Gregory M; Huang, Hao; Hansen, Karl R; Baker, Valerie; Usadi, Rebecca; Seungdamrong, Aimee; Bates, G Wright; Rosen, R Mitchell; Schlaff, William; Haisenleder, Daniel; Krawetz, Stephen A; Barnhart, Kurt; Trussell, J C; Santoro, Nanette; Eisenberg, Esther; Zhang, Heping
2017-08-01
While female sexual dysfunction is a frequent occurrence, characteristics in infertile women are not well delineated. Furthermore, the impact of infertility etiology on the characteristics in women with differing androgen levels observed in women with polycystic ovary syndrome and unexplained infertility has not been assessed. The objective of the study was to determine the characteristics of sexual dysfunction in women with polycystic ovary syndrome and unexplained infertility. A secondary data analysis was performed on 2 of Eunice Kennedy Shriver National Institute of Child Health and Human Development Cooperative Reproductive Medicine Networks clinical trials: Pregnancy in Polycystic Ovary Syndrome Study II and Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation. Both protocols assessed female sexual function using the Female Sexual Function Inventory and the Female Sexual Distress Scale. Women with polycystic ovary syndrome had higher weight and body mass index than women with unexplained infertility (each P < .001), greater phenotypic (Ferriman-Gallwey hirsutism score, sebum score, and acne score; each P < .001), and hormonal (testosterone, free testosterone, and dehydroepiandrosterone; each P < .001) evidence of androgen excess. Sexual function scores, as assessed by the Female Sexual Function Inventory, were nearly identical. The Female Sexual Distress Scale total score was higher in women with polycystic ovary syndrome. The mean Female Sexual Function Inventory total score increased slightly as the free androgen index increased, mainly as a result of the desire subscore. This association was more pronounced in the women with unexplained infertility. Reproductive-age women with infertility associated with polycystic ovary syndrome and unexplained infertility, despite phenotypic and biochemical differences in androgenic manifestations, do not manifest clinically significant differences in sexual function. Copyright © 2017 Elsevier Inc
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Mortality and Morbidity of VLBW Infants With Trisomy 13 or Trisomy 18
Boghossian, Nansi S.; Hansen, Nellie I.; Stoll, Barbara J.; Murray, Jeffrey C.; Carey, John C.; Adams-Chapman, Ira; Shankaran, Seetha; Walsh, Michele C.; Laptook, Abbot R.; Faix, Roger G.; Newman, Nancy S.; Hale, Ellen C.; Das, Abhik; Wilson, Leslie D.; Hensman, Angelita M.; Grisby, Cathy; Collins, Monica V.; Vasil, Diana M.; Finkle, Joanne; Maffett, Deanna; Ball, M. Bethany; Lacy, Conra B.; Bara, Rebecca; Higgins, Rosemary D.
2014-01-01
OBJECTIVE: Little is known about how very low birth weight (VLBW) affects survival and morbidities among infants with trisomy 13 (T13) or trisomy 18 (T18). We examined the care plans for VLBW infants with T13 or T18 and compared their risks of mortality and neonatal morbidities with VLBW infants with trisomy 21 and VLBW infants without birth defects. METHODS: Infants with birth weight 401 to 1500 g born or cared for at a participating center of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network during the period 1994–2009 were studied. Poisson regression models were used to examine risk of death and neonatal morbidities among infants with T13 or T18. RESULTS: Of 52 262 VLBW infants, 38 (0.07%) had T13 and 128 (0.24%) had T18. Intensity of care in the delivery room varied depending on whether the trisomy was diagnosed before or after birth. The plan for subsequent care for the majority of the infants was to withdraw care or to provide comfort care. Eleven percent of infants with T13 and 9% of infants with T18 survived to hospital discharge. Survivors with T13 or T18 had significantly increased risk of patent ductus arteriosus and respiratory distress syndrome compared with infants without birth defects. No infant with T13 or T18 developed necrotizing enterocolitis. CONCLUSIONS: In this cohort of liveborn VLBW infants with T13 or T18, the timing of trisomy diagnosis affected the plan for care, survival was poor, and death usually occurred early. PMID:24446439
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Chromosomal Microarray versus Karyotyping for Prenatal Diagnosis
Wapner, Ronald J.; Martin, Christa Lese; Levy, Brynn; Ballif, Blake C.; Eng, Christine M.; Zachary, Julia M.; Savage, Melissa; Platt, Lawrence D.; Saltzman, Daniel; Grobman, William A.; Klugman, Susan; Scholl, Thomas; Simpson, Joe Leigh; McCall, Kimberly; Aggarwal, Vimla S.; Bunke, Brian; Nahum, Odelia; Patel, Ankita; Lamb, Allen N.; Thom, Elizabeth A.; Beaudet, Arthur L.; Ledbetter, David H.; Shaffer, Lisa G.; Jackson, Laird
2013-01-01
Background Chromosomal microarray analysis has emerged as a primary diagnostic tool for the evaluation of developmental delay and structural malformations in children. We aimed to evaluate the accuracy, efficacy, and incremental yield of chromosomal microarray analysis as compared with karyotyping for routine prenatal diagnosis. Methods Samples from women undergoing prenatal diagnosis at 29 centers were sent to a central karyotyping laboratory. Each sample was split in two; standard karyotyping was performed on one portion and the other was sent to one of four laboratories for chromosomal microarray. Results We enrolled a total of 4406 women. Indications for prenatal diagnosis were advanced maternal age (46.6%), abnormal result on Down’s syndrome screening (18.8%), structural anomalies on ultrasonography (25.2%), and other indications (9.4%). In 4340 (98.8%) of the fetal samples, microarray analysis was successful; 87.9% of samples could be used without tissue culture. Microarray analysis of the 4282 nonmosaic samples identified all the aneuploidies and unbalanced rearrangements identified on karyotyping but did not identify balanced translocations and fetal triploidy. In samples with a normal karyotype, microarray analysis revealed clinically relevant deletions or duplications in 6.0% with a structural anomaly and in 1.7% of those whose indications were advanced maternal age or positive screening results. Conclusions In the context of prenatal diagnostic testing, chromosomal microarray analysis identified additional, clinically significant cytogenetic information as compared with karyotyping and was equally efficacious in identifying aneuploidies and unbalanced rearrangements but did not identify balanced translocations and triploidies. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and others; ClinicalTrials.gov number, NCT01279733.) PMID:23215555
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Smith, P Brian; Ambalavanan, Namasivayam; Li, Lei; Cotten, C Michael; Laughon, Matthew; Walsh, Michele C; Das, Abhik; Bell, Edward F; Carlo, Waldemar A; Stoll, Barbara J; Shankaran, Seetha; Laptook, Abbot R; Higgins, Rosemary D; Goldberg, Ronald N
2012-06-01
We sought to determine if a center's approach to care of premature infants at the youngest gestational ages (22-24 weeks' gestation) is associated with clinical outcomes among infants of older gestational ages (25-27 weeks' gestation). Inborn infants of 401 to 1000 g birth weight and 22 0/7 to 27 6/7 weeks' gestation at birth from 2002 to 2008 were enrolled into a prospectively collected database at 20 centers participating in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Markers of an aggressive approach to care for 22- to 24-week infants included use of antenatal corticosteroids, cesarean delivery, and resuscitation. The primary outcome was death before postnatal day 120 for infants of 25 to 27 weeks' gestation. Secondary outcomes were the combined outcomes of death or a number of morbidities associated with prematurity. Our study included 3631 infants 22 to 24 weeks' gestation and 5227 infants 25 to 27 weeks' gestation. Among the 22- to 24-week infants, use of antenatal corticosteroids ranged from 28% to 100%, cesarean delivery from 13% to 65%, and resuscitation from 30% to 100% by center. Centers with higher rates of antenatal corticosteroid use in 22- to 24-week infants had reduced rates of death, death or retinopathy of prematurity, death or late-onset sepsis, death or necrotizing enterocolitis, and death or neurodevelopmental impairment in 25- to 27-week infants. This study suggests that physicians' willingness to provide care to extremely low gestation infants as measured by frequency of use of antenatal corticosteroids is associated with improved outcomes for more-mature infants.
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Proposed diagnostic criteria for the case definition of amniotic fluid embolism in research studies.
Clark, Steven L; Romero, Roberto; Dildy, Gary A; Callaghan, William M; Smiley, Richard M; Bracey, Arthur W; Hankins, Gary D; D'Alton, Mary E; Foley, Mike; Pacheco, Luis D; Vadhera, Rakesh B; Herlihy, J Patrick; Berkowitz, Richard L; Belfort, Michael A
2016-10-01
Amniotic fluid embolism is a leading cause of maternal mortality in developed countries. Our understanding of risk factors, diagnosis, treatment, and prognosis is hampered by a lack of uniform clinical case definition; neither histologic nor laboratory findings have been identified unique to this condition. Amniotic fluid embolism is often overdiagnosed in critically ill peripartum women, particularly when an element of coagulopathy is involved. Previously proposed case definitions for amniotic fluid embolism are nonspecific, and when viewed through the eyes of individuals with experience in critical care obstetrics, would include women with a number of medical conditions much more common than amniotic fluid embolism. We convened a working group under the auspices of a committee of the Society for Maternal-Fetal Medicine and the Amniotic Fluid Embolism Foundation whose task was to develop uniform diagnostic criteria for the research reporting of amniotic fluid embolism. These criteria rely on the presence of the classic triad of hemodynamic and respiratory compromise accompanied by strictly defined disseminated intravascular coagulopathy. It is anticipated that limiting research reports involving amniotic fluid embolism to women who meet these criteria will enhance the validity of published data and assist in the identification of risk factors, effective treatments, and possibly useful biomarkers for this condition. A registry has been established in conjunction with the Perinatal Research Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development to collect both clinical information and laboratory specimens of women with suspected amniotic fluid embolism in the hopes of identifying unique biomarkers of this condition. Copyright © 2016 Elsevier Inc. All rights reserved.
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Neonatal Outcomes of Extremely Preterm Infants From the NICHD Neonatal Research Network
Stoll, Barbara J.; Hansen, Nellie I.; Bell, Edward F.; Shankaran, Seetha; Laptook, Abbot R.; Walsh, Michele C.; Hale, Ellen C.; Newman, Nancy S.; Schibler, Kurt; Carlo, Waldemar A.; Kennedy, Kathleen A.; Poindexter, Brenda B.; Finer, Neil N.; Ehrenkranz, Richard A.; Duara, Shahnaz; Sánchez, Pablo J.; O’Shea, T. Michael; Goldberg, Ronald N.; Van Meurs, Krisa P.; Faix, Roger G.; Phelps, Dale L.; Frantz, Ivan D.; Watterberg, Kristi L.; Saha, Shampa; Das, Abhik; Higgins, Rosemary D.
2010-01-01
OBJECTIVE This report presents data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network on care of and morbidity and mortality rates for very low birth weight infants, according to gestational age (GA). METHODS Perinatal/neonatal data were collected for 9575 infants of extremely low GA (22–28 weeks) and very low birth weight (401–1500 g) who were born at network centers between January 1, 2003, and December 31, 2007. RESULTS Rates of survival to discharge increased with increasing GA (6% at 22 weeks and 92% at 28 weeks); 1060 infants died at ≤ 12 hours, with most early deaths occurring at 22 and 23 weeks (85% and 43%, respectively). Rates of prenatal steroid use (13% and 53%, respectively), cesarean section (7% and 24%, respectively), and delivery room intubation (19% and 68%, respectively) increased markedly between 22 and 23 weeks. Infants at the lowest GAs were at greatest risk for morbidities. Overall, 93% had respiratory distress syndrome, 46% patent ductus arteriosus, 16% severe intraventricular hemorrhage, 11% necrotizing enterocolitis, and 36% late-onset sepsis. The new severity-based definition of bronchopulmonary dysplasia classified more infants as having bronchopulmonary dysplasia than did the traditional definition of supplemental oxygen use at 36 weeks (68%, compared with 42%). More than one-half of infants with extremely low GAs had undetermined retinopathy status at the time of discharge. Center differences in management and outcomes were identified. CONCLUSION Although the majority of infants with GAs of ≥24 weeks survive, high rates of morbidity among survivors continue to be observed. PMID:20732945
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Batton, Beau; Li, Lei; Newman, Nancy S.; Das, Abhik; Watterberg, Kristi L.; Yoder, Bradley A.; Faix, Roger G.; Laughon, Matthew M.; Stoll, Barbara J.; Higgins, Rosemary D.; Walsh, Michele C.
2016-01-01
Objective Investigate relationships between early blood pressure (BP) changes, receipt of anti-hypotensive therapy, and 18 – 22 month corrected age (CA) outcomes for extremely preterm infants. Design Prospective observational study of infants 230/7 – 266/7 weeks gestational age (GA). Hourly BP values and anti-hypotensive therapy exposure in the first 24 hours were recorded. Four groups were defined: infants who did or did not receive anti-hypotensive therapy in whom BP did or did not rise at the expected rate (defined as an increase in the mean arterial BP of ≥5 mmHg/day). Random-intercept logistic modeling controlling for center clustering, GA, and illness severity was used to investigate the relationship between BP, anti-hypotensive therapies, and infant outcomes. Setting Sixteen academic centers of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Main Outcome Measures Death or neurodevelopmental impairment / developmental delay (NIDD) at 18 – 22 months CA. Results Of 367 infants, 203 (55%) received an anti-hypotensive therapy, 272 (74%) survived to discharge, and 331 (90%) had a known outcome at 18 – 22 months CA. With logistic regression, there was an increased risk of death/NIDD with anti-hypotensive therapy versus no treatment (odds ratio: 1.836, 95% confidence interval: 1.092 – 3.086), but not NIDD alone (odds ratio: 1.53, 95% confidence interval: 0.708 – 3.307). Conclusion Independent of early BP changes, anti-hypotensive therapy exposure was associated with an increased risk of death/NIDD at 18 to 22 months CA when controlling for risk factors known to affect survival and neurodevelopment. PMID:26567120
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Extemporaneous drug formulations.
Nahata, Milap C; Allen, Loyd V
2008-11-01
Access to a special dosage form of a medication is essential when administration to infants and children and selected other populations is required. Some drugs necessary for pediatric patients are not commercially available in dosage forms appropriate for use in this population. These drugs may be prepared extemporaneously for use in individual patients. Physical and chemical properties of drugs and excipients should be considered when preparing extemporaneous formulations. These formulations, however, may lack studies to document stability, bioavailability, pharmacokinetics, pharmacodynamics, efficacy, and tolerability. The goal of this article was to discuss factors involved in extemporaneous compounding of pediatric dosage forms. The proceedings from a Pediatric Formulation Initiative workshop sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, held December 6 and 7, 2005, in Bethesda, Maryland, were used as a source of information for this article. A literature search of PubMed/ MEDLINE (1966-October 2008) was also conducted, using the search terms extemporaneous, drug formulations, and pediatric. Access to age-appropriate drug formulations is critical to provide effective and well-tolerated medications to patients. There continues to be a need for extemporaneous formulations of brand and generic drugs for neonates, infants, and children. Potential solutions to current limitations include the need to develop a prioritized list of essential formulations, increased funding of research, dissemination of data, and monitoring of clinical effectiveness and tolerability during use in various age groups of pediatric patients and the sharing of these clinical experiences. To achieve desired therapeutic outcomes in pediatric patients, access to age-appropriate, stable, effective, and well-tolerated drug formulations is essential.
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Cuna, Alain; Liu, Cynthia; Govindarajan, Shree; Queen, Margaret; Dai, Hongying; Truog, William E
2018-06-01
To assess the usefulness of a bronchopulmonary dysplasia (BPD) outcome estimator developed by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) in identifying high-risk preterm infants treated with steroids. This was a single-center retrospective study of infants born ≤30 weeks of gestational age. The NICHD BPD outcome estimator was used to retrospectively calculate BPD risk at various postnatal ages. The best combination of risk estimates for identifying steroid treatment was identified using stepwise model selection. A cut-off value with the best combination of sensitivity and specificity was identified using receiver operating characteristic analysis. A total of 165 infants born preterm (mean gestational age 26 ± 1.6 weeks, mean birth weight 837 ± 171 g) were included. Of these, 61 were treated with steroids for BPD and 104 were not. Risk estimates for BPD or death were significantly greater in infants treated with steroids compared with controls. Both combined risk for severe BPD or death and single risk of no BPD were identified as factors with the best predictive power for identifying treatment with steroids, with accurate prediction possible as early as the second week of life. A greater than 37% risk for severe BPD or death or a less than 3% risk of no BPD on day of life 14 had 84%-92% sensitivity and 77%-80% specificity for predicting steroid treatment. The NICHD BPD outcome estimator can be a useful objective tool for identifying infants at high risk for BPD who may benefit from postnatal steroids. Copyright © 2018 Elsevier Inc. All rights reserved.
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Ambalavanan, Namasivayam; Li, Lei; Cotten, C. Michael; Laughon, Matthew; Walsh, Michele C.; Das, Abhik; Bell, Edward F.; Carlo, Waldemar A.; Stoll, Barbara J.; Shankaran, Seetha; Laptook, Abbot R.; Higgins, Rosemary D.; Goldberg, Ronald N.
2012-01-01
OBJECTIVE: We sought to determine if a center’s approach to care of premature infants at the youngest gestational ages (22–24 weeks’ gestation) is associated with clinical outcomes among infants of older gestational ages (25–27 weeks’ gestation). METHODS: Inborn infants of 401 to 1000 g birth weight and 22 0/7 to 27 6/7 weeks’ gestation at birth from 2002 to 2008 were enrolled into a prospectively collected database at 20 centers participating in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Markers of an aggressive approach to care for 22- to 24-week infants included use of antenatal corticosteroids, cesarean delivery, and resuscitation. The primary outcome was death before postnatal day 120 for infants of 25 to 27 weeks’ gestation. Secondary outcomes were the combined outcomes of death or a number of morbidities associated with prematurity. RESULTS: Our study included 3631 infants 22 to 24 weeks’ gestation and 5227 infants 25 to 27 weeks’ gestation. Among the 22- to 24-week infants, use of antenatal corticosteroids ranged from 28% to 100%, cesarean delivery from 13% to 65%, and resuscitation from 30% to 100% by center. Centers with higher rates of antenatal corticosteroid use in 22- to 24-week infants had reduced rates of death, death or retinopathy of prematurity, death or late-onset sepsis, death or necrotizing enterocolitis, and death or neurodevelopmental impairment in 25- to 27-week infants. CONCLUSIONS: This study suggests that physicians’ willingness to provide care to extremely low gestation infants as measured by frequency of use of antenatal corticosteroids is associated with improved outcomes for more-mature infants. PMID:22641761
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Intercenter Differences in Bronchopulmonary Dysplasia or Death Among Very Low Birth Weight Infants
Walsh, Michele; Bobashev, Georgiy; Das, Abhik; Levine, Burton; Carlo, Waldemar A.; Higgins, Rosemary D.
2011-01-01
OBJECTIVES: To determine (1) the magnitude of clustering of bronchopulmonary dysplasia (36 weeks) or death (the outcome) across centers of the Eunice Kennedy Shriver National Institute of Child and Human Development National Research Network, (2) the infant-level variables associated with the outcome and estimate their clustering, and (3) the center-specific practices associated with the differences and build predictive models. METHODS: Data on neonates with a birth weight of <1250 g from the cluster-randomized benchmarking trial were used to determine the magnitude of clustering of the outcome according to alternating logistic regression by using pairwise odds ratio and predictive modeling. Clinical variables associated with the outcome were identified by using multivariate analysis. The magnitude of clustering was then evaluated after correction for infant-level variables. Predictive models were developed by using center-specific and infant-level variables for data from 2001 2004 and projected to 2006. RESULTS: In 2001–2004, clustering of bronchopulmonary dysplasia/death was significant (pairwise odds ratio: 1.3; P < .001) and increased in 2006 (pairwise odds ratio: 1.6; overall incidence: 52%; range across centers: 32%–74%); center rates were relatively stable over time. Variables that varied according to center and were associated with increased risk of outcome included lower body temperature at NICU admission, use of prophylactic indomethacin, specific drug therapy on day 1, and lack of endotracheal intubation. Center differences remained significant even after correction for clustered variables. CONCLUSION: Bronchopulmonary dysplasia/death rates demonstrated moderate clustering according to center. Clinical variables associated with the outcome were also clustered. Center differences after correction of clustered variables indicate presence of as-yet unmeasured center variables. PMID:21149431
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Obama Kennedy Space Center Visit
2010-04-14
Members of the press watch on monitors as President Barack Obama delivers a speech at the Operations and Checkout Building at NASA Kennedy Space Center in Cape Canaveral, Fla. on Thursday, April 15, 2010. Obama visited Kennedy Space Center to deliver remarks on the bold new course the Administration is charting for NASA and the future of U.S. leadership in human space flight. Photo Credit: (NASA/Bill Ingalls)
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Obama Kennedy Space Center Visit
2010-04-14
Air Force One is seen as it prepares to depart from the NASA SHuttle Landing Facility (SLF) after President Barack Obama delivered a speech at the NASA Kennedy Space Center in Cape Canaveral, Fla. on Thursday, April 15, 2010. Obama visited Kennedy Space Center to deliver remarks on the bold new course the Administration is charting for NASA and the future of U.S. leadership in human space flight. Photo Credit: (NASA/Bill Ingalls)
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A new customized fetal growth standard for African American women: the PRB/NICHD Detroit Study
Tarca, Adi L.; Romero, Roberto; Gudicha, Dereje W.; Erez, Offer; Hernandez-Andrade, Edgar; Yeo, Lami; Bhatti, Gaurav; Pacora, Percy; Maymon, Eli; Hassan, Sonia S.
2018-01-01
Background The assessment of fetal growth disorders requires a standard. Current nomograms for the assessment of fetal growth in African American women have been derived either from neonatal (rather than fetal) biometry data or have not been customized for maternal ethnicity, weight, height, parity, and fetal sex. Objective We sought to 1) develop a new customized fetal growth standard for African American mothers; and 2) compare such a standard to three existing standards for the classification of fetuses as small (SGA) or large (LGA) for gestational age. Study Design A retrospective cohort study included 4,183 women (4,001 African American and 182 Caucasian) from the Detroit metropolitan area who underwent ultrasound examinations between 14 and 40 weeks of gestation (the median number of scans per pregnancy was 5, interquartile range 3-7) and for whom relevant covariate data were available. Longitudinal quantile regression was used to build models defining the “normal” estimated fetal weight (EFW) centiles for gestational age in African American women, adjusted for maternal height, weight, parity, and fetal sex, and excluding pathologic factors with a significant effect on fetal weight. The resulting Perinatology Research Branch/Eunice Kennedy Shriver National Institute of Child Health and Human Development (hereinafter, PRB/NICHD) growth standard was compared to 3 other existing standards—the customized gestation-related optimal weight (GROW) standard; the Eunice Kennedy Shriver National Institute of Child Health and Human Development (hereinafter, NICHD) African American standard; and the multinational World Health Organization (WHO) standard—utilized to screen fetuses for SGA (<10th centile) or LGA (>90th centile) based on the last available ultrasound examination for each pregnancy. Results 1) First, the mean birthweight at 40 weeks was 133g higher for neonates born to Caucasian than to African American mothers and 150g higher for male than female
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NASA Technical Reports Server (NTRS)
Simpkins, Patrick A.
2010-01-01
This slide presentation reviews the importance of the Kennedy Space Center both in terms to the economy of Florida and to spaceflight. It reviews the general NASA direction,the challenges of the coming year and the accomplishments.
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2008-05-03
CAPE CANAVERAL, Fla. -- The new inductees into the U.S. Astronaut Hall of Fame step forward on stage for photographs following their induction. From left are Loren Shriver; Bryan O'Connor, NASA's chief of Safety and Mission Assurance at NASA Headquarters in Washington; John Blaha; and Robert Cabana, center director of NASA's Stennis Space Center in Mississippi. The ceremony was held May 3 at NASA's Kennedy Space Center. Other former astronauts attending included Scott Carpenter, John Young, Bob Crippen, and Walt Cunningham. The U.S. Astronaut Hall of Fame is operated by Kennedy Space Center Visitor Complex on behalf of NASA. CNN correspondent John Zarrella hosted the event.
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2008-05-03
CAPE CANAVERAL, Fla. -- Members of the U.S. Astronaut Hall of Fame stand for an ovation following the induction of the newest members (at center): Loren Shriver; Bryan O'Connor, NASA's chief of Safety and Mission Assurance at NASA Headquarters in Washington; John Blaha; and Robert Cabana, center director of NASA's Stennis Space Center in Mississippi. The ceremony was held May 3 at NASA's Kennedy Space Center. Other former astronauts attending included Scott Carpenter, John Young, Bob Crippen, and Walt Cunningham. The U.S. Astronaut Hall of Fame is operated by Kennedy Space Center Visitor Complex on behalf of NASA. CNN correspondent John Zarrella hosted the event.
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2008-05-03
CAPE CANAVERAL, Fla. -- Former astronaut Loren Shriver (center) is inducted into the U.S. Astronaut Hall of Fame May 3 at NASA's Kennedy Space Center. Presenting the medal are former inductees Al Worden (left) and Charles Bolden (right). Other inductees were John Blaha; Bryan O'Connor, NASA's chief of Safety and Mission Assurance at NASA Headquarters in Washington; and Bob Cabana, center director of NASA's Stennis Space Center in Mississippi. Other former astronauts attending included Scott Carpenter, John Young, Bob Crippen, and Walt Cunningham. The U.S. Astronaut Hall of Fame is operated by Kennedy Space Center Visitor Complex on behalf of NASA. CNN correspondent John Zarrella hosted the event.
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2008-05-03
CAPE CANAVERAL, Fla. -- Former astronaut John Blaha (center) is inducted into the U.S. Astronaut Hall of Fame May 3 at NASA's Kennedy Space Center. Presenting the medal are former inductees Al Worden (left) and Fred Gregory (right). Other inductees were Loren Shriver; Bryan O'Connor, NASA's chief of Safety and Mission Assurance at NASA Headquarters in Washington; and Bob Cabana, center director of NASA's Stennis Space Center in Mississippi. Other former astronauts attending included Scott Carpenter, John Young, Bob Crippen, and Walt Cunningham. The U.S. Astronaut Hall of Fame is operated by Kennedy Space Center Visitor Complex on behalf of NASA. CNN correspondent John Zarrella hosted the event.
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2008-05-03
CAPE CANAVERAL, Fla. -- Former astronaut John Blaha (center) receives congratulations on his induction into the U.S. Astronaut Hall of Fame May 3 at NASA's Kennedy Space Center from former inductees Al Worden (left) and Fred Gregory (right). Other inductees were Loren Shriver; Bryan O'Connor, NASA's chief of Safety and Mission Assurance at NASA Headquarters in Washington; and Bob Cabana, center director of NASA's Stennis Space Center in Mississippi. Other former astronauts attending included Scott Carpenter, John Young, Bob Crippen, and Walt Cunningham. The U.S. Astronaut Hall of Fame is operated by Kennedy Space Center Visitor Complex on behalf of NASA. CNN correspondent John Zarrella hosted the event.
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2008-05-03
CAPE CANAVERAL, Fla. -- Former astronaut and NASA's chief of Safety and Mission Assurance at NASA Headquarters in Washington, Bryan O'Connor (center) is inducted into the U.S. Astronaut Hall of Fame May 3 at NASA's Kennedy Space Center. Presenting the medal are former inductees Al Worden (left) and Brewster Shaw (right). Other inductees were John Blaha, Loren Shriver; and Bob Cabana, center director of NASA's Stennis Space Center in Mississippi. Other former astronauts attending included Scott Carpenter, John Young, Bob Crippen, and Walt Cunningham. The U.S. Astronaut Hall of Fame is operated by Kennedy Space Center Visitor Complex on behalf of NASA. CNN correspondent John Zarrella hosted the event.
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
During his visit of NASA's Kennedy Space Center in Florida, Vice President Mike Pence signs a Kennedy Space Center guest book as the agency's Acting Administrator Robert Lightfoot, left, and Center Director Bob Cabana look on. During his visit to Kennedy, the Vice President spoke inside the iconic Vehicle Assembly Building, where he thanked employees for advancing American leadership in space.
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Vice President Mike Pence Arrival at Kennedy Space Center
2017-07-06
Accompanied by a White House staffer, left, NASA Kennedy Space Center Director Robert Cabana, Acting NASA Administrator Robert Lightfoot and Kennedy Space Center Deputy Director Janet Petro watch as Air Force Two, carrying Vice President Mike Pence, approaches on the Shuttle Landing Facility at NASA's Kennedy Space Center in Florida. During his visit to Kennedy, Pence spoke inside the iconic Vehicle Assembly Building, where he thanked employees for advancing American leadership in space.
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Obama Kennedy Space Center Visit
2010-04-14
President Barack Obama, left, exits of Air Force One with, from left, Representative US Representative Suzanne M. Kosmas (D - FL), U.S Senator Bill Nelson (D-FL), NASA Administrator Charles Bolden, and Apollo 11 Astronaut Buzz Aldrin after landing at the NASA Kennedy Space Center in Cape Canaveral, Fla. on Thursday, April 15, 2010. Obama visited Kennedy to deliver remarks on the bold new course the administration is charting to maintain U.S. leadership in human space flight. Photo Credit: (NASA/Bill Ingalls)
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Vice President Mike Pence visits Kennedy Space Center
2017-07-06
Vice President Mike Pence, second from right; NASA Acting Administrator Robert Lightfoot, left; Deputy Director, Kennedy Space Center, Janet Petro, second from left; NASA astronaut Reid Wiseman, center; and Director, Kennedy Space Center, Robert Cabana, right, look at the Orion capsule that will fly on the first integrated flight with the Space Launch System rocket in 2019, during a tour of the Kennedy Space Center's Operations and Checkout Building.
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Vice President Mike Pence Arrival at Kennedy Space Center
2017-07-06
Vice President Mike Pence greets NASA Kennedy Space Center Director Robert Cabana after arriving aboard Air Force Two at NASA's Kennedy Space Center in Florida. During his visit to Kennedy, Pence spoke inside the iconic Vehicle Assembly Building, where he thanked employees for advancing American leadership in space.
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Human Spaceflight The Kennedy Legacy
2011-05-25
Actress Nichelle Nichols, best known for her role as communications officer Lieutenant Uhura in the series "Star Trek", sings as she is escorted on stage, Wednesday, May 25, 2011, in the concert hall at the John F. Kennedy Center for the Performing Arts in Washington. The event marked the 50th Anniversary of President John F. Kennedy's Special Message to the Congress on Urgent National Needs in which he stated "landing a man on the moon and returning him safely to earth". Photo Credit: (NASA/Paul E. Alers)
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Antenatal magnesium sulfate exposure and acute cardiorespiratory events in preterm infants.
De Jesus, Lilia C; Sood, Beena G; Shankaran, Seetha; Kendrick, Douglas; Das, Abhik; Bell, Edward F; Stoll, Barbara J; Laptook, Abbot R; Walsh, Michele C; Carlo, Waldemar A; Sanchez, Pablo J; Van Meurs, Krisa P; Bara, Rebecca; Hale, Ellen C; Newman, Nancy S; Ball, M Bethany; Higgins, Rosemary D
2015-01-01
Antenatal magnesium (anteMg) is used for various obstetric indications including fetal neuroprotection. Infants exposed to anteMg may be at risk for respiratory depression and delivery room (DR) resuscitation. The study objective was to compare the risk of acute cardiorespiratory events among preterm infants who were and were not exposed to anteMg. This was a retrospective analysis of prospective data collected in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's Generic Database from April 1, 2011, through March 31, 2012. The primary outcome was DR intubation or respiratory support at birth or on day 1 of life. Secondary outcomes were invasive mechanical ventilation, hypotension treatment, neonatal morbidities, and mortality. Logistic regression analysis evaluated the risk of primary outcome after adjustment for covariates. We evaluated 1544 infants <29 weeks' gestational age (1091 in anteMg group and 453 in nonexposed group). Mothers in the anteMg group were more likely to have higher education, pregnancy-induced hypertension, and antenatal corticosteroids, while their infants were younger in gestation and weighed less (P < .05). The primary outcome (odds ratio [OR], 1.2; 95% confidence interval [CI], 0.88-1.65) was similar between groups. Hypotension treatment (OR, 0.70; 95% CI, 0.51-0.97) and invasive mechanical ventilation (OR, 0.54; 95% CI, 0.41-0.72) were significantly less in the anteMg group. Among preterm infants age <29 weeks' gestation, anteMg exposure was not associated with an increase in cardiorespiratory events in the early newborn period. The safety of anteMg as measured by the need for DR intubation or respiratory support on day 1 of life was comparable between groups. Copyright © 2015 Elsevier Inc. All rights reserved.
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Oliveira, Ricardo; Krauss, Margot; Essama-Bibi, Suzanne; Hofer, Cristina; Harris, D. Robert; Tiraboschi, Adriana; de Souza, Ricardo; Marques, Heloisa; Succi, Regina; Abreu, Thalita; Della Negra, Marinella; Hazra, Rohan; Mofenson, Lynne M.; Siberry, George K.
2010-01-01
Background. Many resource-limited countries rely on clinical and immunological monitoring without routine virological monitoring for human immunodeficiency virus (HIV)-infected children receiving highly active antiretroviral therapy (HAART). We assessed whether HIV load had independent predictive value in the presence of immunological and clinical data for the occurrence of new World Health Organization (WHO) stage 3 or 4 events (hereafter, WHO events) among HIV-infected children receiving HAART in Latin America. Methods. The NISDI (Eunice Kennedy Shriver National Institute of Child Health and Human Development International Site Development Initiative) Pediatric Protocol is an observational cohort study designed to describe HIV-related outcomes among infected children. Eligibility criteria for this analysis included perinatal infection, age <15 years, and continuous HAART for ≥6 months. Cox proportional hazards modeling was used to assess time to new WHO events as a function of immunological status, viral load, hemoglobin level, and potential confounding variables; laboratory tests repeated during the study were treated as time-varying predictors. Results. The mean duration of follow-up was 2.5 years; new WHO events occurred in 92 (15.8%) of 584 children. In proportional hazards modeling, most recent viral load >5000 copies/mL was associated with a nearly doubled risk of developing a WHO event (adjusted hazard ratio, 1.81; 95% confidence interval, 1.05–3.11; P = .033), even after adjustment for immunological status defined on the basis of CD4 T lymphocyte value, hemoglobin level, age, and body mass index. Conclusions. Routine virological monitoring using the WHO virological failure threshold of 5000 copies/mL adds independent predictive value to immunological and clinical assessments for identification of children receiving HAART who are at risk for significant HIV-related illness. To provide optimal care, periodic virological monitoring should be considered
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Induction of labor versus expectant management for women with a prior cesarean delivery.
Palatnik, Anna; Grobman, William A
2015-03-01
Previous studies of induction of labor in the setting of trial of labor after cesarean have compared women undergoing trial of labor after cesarean to those undergoing spontaneous labor. However, the clinically relevant comparison is to those undergoing expectant management. The objective of this study was to compare obstetric outcomes between women undergoing induction of labor and those undergoing expectant management ≥39 weeks of gestation. This was a secondary analysis of data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Cesarean Registry that included women with singleton gestations at a gestational age of ≥39 weeks and a history of 1 low transverse cesarean delivery. Outcomes of induction at 39, 40, and 41 weeks were compared to expectant management beyond each gestational age period using univariable and multivariable analyses. Women with scheduled repeat cesarean deliveries done for the indication of prior cesarean delivery were excluded from the analysis. In all, 12,676 women were eligible for analysis. The rate of vaginal birth after cesarean (VBAC) was higher among women undergoing induction of labor at 39 weeks compared to expectant management (73.8% vs 61.3%, P < .001). The risk of uterine rupture also was higher among women undergoing induction of labor at 39 weeks compared to expectant management (1.4% vs 0.5%, P = .006, respectively). In multivariable analysis, induction of labor at 39 weeks remained associated with a significantly higher chance of VBAC and uterine rupture (odds ratio, 1.31; 95% confidence interval, 1.03-1.67; and odds ratio, 2.73; 95% confidence interval, 1.22-6.12, respectively). Induction of labor at 39 weeks, when compared to expectant management, was associated with a higher chance of VBAC but also of uterine rupture. Copyright © 2015 Elsevier Inc. All rights reserved.
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Second-stage labor: how long is too long?
Leveno, Kenneth J; Nelson, David B; McIntire, Donald D
2016-04-01
The management of labor has come under increased scrutiny due to the rapid escalation of cesarean delivery in the United States. A workshop of the Society for Maternal-Fetal Medicine, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the American Congress of Obstetricians and Gynecologists was convened to address the rising cesarean delivery rates and one of their recommendations was that the accepted upper limit of the second stage of labor should be increased to ≥4 hours in nulliparous women with epidural analgesia and to ≥3 hours in parous women with epidural. This led to the inaugural Obstetric Care Consensus series document, "Safe Prevention of the Primary Cesarean Delivery," wherein the workshop recommendations on second-stage labor were promulgated nationally. The result is that the now acceptable maximum length of the second stage of labor exceeds the obstetric precepts that have been in use for >50 years. In this Clinical Opinion, we review the evidence on infant safety, vis-à-vis length of the second stage of labor. Our examination of the evidence begins at the outset of the 20th century and culminates in the very recent (2014) recommendation to abandon the long accepted obstetric paradigm that second-stage labor >3 hours in nulliparous women with labor epidural is unsafe for the unborn infant. We conclude that the currently available evidence fails to support the Obstetric Care Consensus position that longer second-stage labor is safe for the unborn infant. Indeed, the evidence suggests quite the opposite. We suggest that when infant safety is at stake the evidence should be robust before a new clinical road is taken. The evidence is not robust. Copyright © 2016 Elsevier Inc. All rights reserved.
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Estimating Gestational Age From Ultrasound Fetal Biometrics.
Skupski, Daniel W; Owen, John; Kim, Sungduk; Fuchs, Karin M; Albert, Paul S; Grantz, Katherine L
2017-08-01
To compare the accuracy of a new formula with one developed in 1984 (and still in common use) and to develop and compare racial and ethnic-specific and racial and ethnic-neutral formulas. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singletons was a prospective cohort study that recruited women in four self-reported racial-ethnic groups-non-Hispanic black, Hispanic, non-Hispanic white, and Asian-with singleton gestations from 12 U.S. centers (2009-2013). Women with a certain last menstrual period confirmed by first-trimester ultrasonogram had longitudinal fetal measurements by credentialed study ultrasonographers blinded to the gestational age at their five follow-up visits. Regression analyses were performed with linear mixed models to develop gestational age estimating formulas. Repeated cross-validation was used for validation. The estimation error was defined as the mean squared difference between the estimated and observed gestational age and was used to compare the formulas' accuracy. The new formula estimated the gestational age (±2 SD) within ±7 days from 14 to 20 weeks of gestation, ±10 days from 21 to 27 weeks of gestation, and ±17 days from 28 to 40 weeks of gestation. The new formula performed significantly better than a formula developed in 1984 with an estimation error of 10.4 compared with 11.2 days from 21 to 27 weeks of gestation and 17.0 compared with 19.8 days at 28-40 weeks of gestation, respectively. Racial and ethnic-specific formulas did not outperform the racial and ethnic-neutral formula. The NICHD gestational age estimation formula is associated with smaller errors than a well-established historical formula. Racial and ethnic-specific formulas are not superior to a racial-ethnic-neutral one.
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Association of Fetal Heart Rate Baseline Change and Neonatal Outcomes.
Yang, Michael; Stout, Molly J; López, Julia D; Colvin, Ryan; Macones, George A; Cahill, Alison G
2017-07-01
Objective The objective of this study was to describe the incidence of baseline change within normal range during labor and its prediction of neonatal outcomes. Materials and Methods This was a prospective cohort of singleton, nonanomalous, term neonates with continuous electronic fetal monitoring and normal baseline fetal heart rate throughout the last 2 hours of labor. We determined baseline in 10-minute segments using Eunice Kennedy Shriver National Institute of Child Health and Human Development criteria. We evaluated baseline changes of ≥ 20 and ≥ 30 bpm for association with acidemia (umbilical cord arterial pH ≤ 7.10) and neonatal intensive care unit (NICU) admission. Finally, we performed a sensitivity analysis of normal neonates, excluding those with acidemia, NICU admission, or 5-minute Apgar < 4. Results Among all neonates ( n = 3,021), 1,267 (41.9%) had change ≥ 20 bpm; 272 (9.0%) had ≥ 30 bpm. Among normal neonates ( n = 2,939), 1,221 (41.5%) had change ≥20 bpm. Acidemia was not associated with baseline change of any direction or magnitude. NICU admission was associated with decrease ≥ 20 bpm (adjusted odds ratio [aOR]: 2.93; 95% confidence interval [CI]: 1.19 - 7.21) or any direction ≥ 20 bpm (aOR: 4.06; 95% CI: 1.46-11.29). For decrease ≥ 20 bpm, sensitivity and specificity were 40.0 and 81.7%; for any direction ≥ 20 bpm, 75.0 and 58.3%. Conclusion Changes of normal baseline are common in term labor and poorly predict morbidity, regardless of direction or magnitude. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
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Outcomes of Extremely Preterm Infants Born to Insulin-Dependent Diabetic Mothers
Boghossian, Nansi S.; Hansen, Nellie I.; Brumbaugh, Jane E.; Stoll, Barbara J.; Laptook, Abbot R.; Shankaran, Seetha; Wyckoff, Myra H.; Colaizy, Tarah T.; Das, Abhik; Higgins, Rosemary D.
2016-01-01
BACKGROUND AND OBJECTIVE: Little is known about in-hospital morbidities and neurodevelopmental outcomes among extremely preterm infants born to women with insulin-dependent diabetes mellitus (IDDM). We examined risks of mortality, in-hospital morbidities, and neurodevelopmental outcomes at 18 to 22 months’ corrected age between extremely preterm infants of women with insulin use before pregnancy (IBP), with insulin use started during pregnancy (IDP), and without IDDM. METHODS: Infants 22 to 28 weeks’ gestation born or cared for at a Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network center (2006–2011) were studied. Regression models compared the association between maternal IDDM and timing of insulin use and the outcomes of the 3 groups. RESULTS: Of 10 781 infants, 536 (5%) were born to women with IDDM; 58% had IBP, and 36% had IDP. Infants of mothers with IBP had higher risks of necrotizing enterocolitis (adjusted relative risk [RR] = 1.55 [95% confidence interval (CI) 1.17–2.05]) and late-onset sepsis (adjusted RR = 1.26 [95% CI 1.07–1.48]) than infants of mothers without IDDM. There was some indication of higher in-hospital mortality risk among infants of mothers with IBP compared with those with IDP (adjusted RR = 1.33 [95% CI 1.00–1.79]). Among survivors evaluated at 18 to 22 months’ corrected age, average head circumference z score was lower for infants of mothers with IBP compared with those without IDDM, but there were no differences in risk of neurodevelopmental impairment. CONCLUSIONS: In this cohort of extremely preterm infants, infants of mothers with IBP had higher risks of necrotizing enterocolitis, sepsis, and small head circumference. PMID:27244849
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Ten-Year Review of Major Birth Defects in VLBW Infants
Hansen, Nellie I.; Shankaran, Seetha; Bell, Edward F.; Boghossian, Nansi S.; Murray, Jeffrey C.; Laptook, Abbot R.; Walsh, Michele C.; Carlo, Waldemar A.; Sánchez, Pablo J.; Van Meurs, Krisa P.; Das, Abhik; Hale, Ellen C.; Newman, Nancy S.; Ball, M. Bethany; Higgins, Rosemary D.; Stoll, Barbara J.
2013-01-01
OBJECTIVE: Birth defects (BDs) are an important cause of infant mortality and disproportionately occur among low birth weight infants. We determined the prevalence of BDs in a cohort of very low birth weight (VLBW) infants cared for at the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN) centers over a 10-year period and examined the relationship between anomalies, neonatal outcomes, and surgical care. METHODS: Infant and maternal data were collected prospectively for infants weighing 401 to 1500 g at NRN sites between January 1, 1998, and December 31, 2007. Poisson regression models were used to compare risk of outcomes for infants with versus without BDs while adjusting for gestational age and other characteristics. RESULTS: A BD was present in 1776 (4.8%) of the 37 262 infants in our VLBW cohort. Yearly prevalence of BDs increased from 4.0% of infants born in 1998 to 5.6% in 2007, P < .001. Mean gestational age overall was 28 weeks, and mean birth weight was 1007 g. Infants with BDs were more mature but more likely to be small for gestational age compared with infants without BDs. Chromosomal and cardiovascular anomalies were most frequent with each occurring in 20% of affected infants. Mortality was higher among infants with BDs (49% vs 18%; adjusted relative risk: 3.66 [95% confidence interval: 3.41–3.92]; P < .001) and varied by diagnosis. Among those surviving >3 days, more infants with BDs underwent major surgery (48% vs 13%, P < .001). CONCLUSIONS: Prevalence of BDs increased during the 10 years studied. BDs remain an important cause of neonatal morbidity and mortality among VLBW infants. PMID:23733791
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Hansen, Nellie I.; Stoll, Barbara J.; Bell, Edward F.; Sánchez, Pablo J.; Shankaran, Seetha; Laptook, Abbot R.; Das, Abhik; Walsh, Michele C.; Hale, Ellen C.; Newman, Nancy S.; Schrag, Stephanie J.; Higgins, Rosemary D.
2012-01-01
BACKGROUND: Data are limited on the impact of methicillin-resistant Staphylococcus aureus (MRSA) on morbidity and mortality among very low birth weight (VLBW) infants with S aureus (SA) bacteremia and/or meningitis (B/M). METHODS: Neonatal data for VLBW infants (birth weight 401–1500 g) born January 1, 2006, to December 31, 2008, who received care at centers of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network were collected prospectively. Early-onset (≤72 hours after birth) and late-onset (>72 hours) infections were defined by blood or cerebrospinal fluid cultures and antibiotic treatment of ≥5 days (or death <5 days with intent to treat). Outcomes were compared for infants with MRSA versus methicillin-susceptible S aureus (MSSA) B/M. RESULTS: Of 8444 infants who survived >3 days, 316 (3.7%) had SA B/M. Eighty-eight had MRSA (1% of all infants, 28% of infants with SA); 228 had MSSA (2.7% of all infants, 72% of infants with SA). No infant had both MRSA and MSSA B/M. Ninety-nine percent of MRSA infections were late-onset. The percent of infants with MRSA varied by center (P < .001) with 9 of 20 centers reporting no cases. Need for mechanical ventilation, diagnosis of respiratory distress syndrome, necrotizing enterocolitis, and other morbidities did not differ between infants with MRSA and MSSA. Mortality was high with both MRSA (23 of 88, 26%) and MSSA (55 of 228, 24%). CONCLUSIONS: Few VLBW infants had SA B/M. The 1% with MRSA had morbidity and mortality rates similar to infants with MSSA. Practices should provide equal focus on prevention and management of both MRSA and MSSA infections among VLBW infants. PMID:22412036
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Karyotype versus microarray testing for genetic abnormalities after stillbirth.
Reddy, Uma M; Page, Grier P; Saade, George R; Silver, Robert M; Thorsten, Vanessa R; Parker, Corette B; Pinar, Halit; Willinger, Marian; Stoll, Barbara J; Heim-Hall, Josefine; Varner, Michael W; Goldenberg, Robert L; Bukowski, Radek; Wapner, Ronald J; Drews-Botsch, Carolyn D; O'Brien, Barbara M; Dudley, Donald J; Levy, Brynn
2012-12-06
Genetic abnormalities have been associated with 6 to 13% of stillbirths, but the true prevalence may be higher. Unlike karyotype analysis, microarray analysis does not require live cells, and it detects small deletions and duplications called copy-number variants. The Stillbirth Collaborative Research Network conducted a population-based study of stillbirth in five geographic catchment areas. Standardized postmortem examinations and karyotype analyses were performed. A single-nucleotide polymorphism array was used to detect copy-number variants of at least 500 kb in placental or fetal tissue. Variants that were not identified in any of three databases of apparently unaffected persons were then classified into three groups: probably benign, clinical significance unknown, or pathogenic. We compared the results of karyotype and microarray analyses of samples obtained after delivery. In our analysis of samples from 532 stillbirths, microarray analysis yielded results more often than did karyotype analysis (87.4% vs. 70.5%, P<0.001) and provided better detection of genetic abnormalities (aneuploidy or pathogenic copy-number variants, 8.3% vs. 5.8%; P=0.007). Microarray analysis also identified more genetic abnormalities among 443 antepartum stillbirths (8.8% vs. 6.5%, P=0.02) and 67 stillbirths with congenital anomalies (29.9% vs. 19.4%, P=0.008). As compared with karyotype analysis, microarray analysis provided a relative increase in the diagnosis of genetic abnormalities of 41.9% in all stillbirths, 34.5% in antepartum stillbirths, and 53.8% in stillbirths with anomalies. Microarray analysis is more likely than karyotype analysis to provide a genetic diagnosis, primarily because of its success with nonviable tissue, and is especially valuable in analyses of stillbirths with congenital anomalies or in cases in which karyotype results cannot be obtained. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development.).
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Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.
Trivellin, Giampaolo; Daly, Adrian F; Faucz, Fabio R; Yuan, Bo; Rostomyan, Liliya; Larco, Darwin O; Schernthaner-Reiter, Marie Helene; Szarek, Eva; Leal, Letícia F; Caberg, Jean-Hubert; Castermans, Emilie; Villa, Chiara; Dimopoulos, Aggeliki; Chittiboina, Prashant; Xekouki, Paraskevi; Shah, Nalini; Metzger, Daniel; Lysy, Philippe A; Ferrante, Emanuele; Strebkova, Natalia; Mazerkina, Nadia; Zatelli, Maria Chiara; Lodish, Maya; Horvath, Anelia; de Alexandre, Rodrigo Bertollo; Manning, Allison D; Levy, Isaac; Keil, Margaret F; Sierra, Maria de la Luz; Palmeira, Leonor; Coppieters, Wouter; Georges, Michel; Naves, Luciana A; Jamar, Mauricette; Bours, Vincent; Wu, T John; Choong, Catherine S; Bertherat, Jerome; Chanson, Philippe; Kamenický, Peter; Farrell, William E; Barlier, Anne; Quezado, Martha; Bjelobaba, Ivana; Stojilkovic, Stanko S; Wess, Jurgen; Costanzi, Stefano; Liu, Pengfei; Lupski, James R; Beckers, Albert; Stratakis, Constantine A
2014-12-18
Increased secretion of growth hormone leads to gigantism in children and acromegaly in adults; the genetic causes of gigantism and acromegaly are poorly understood. We performed clinical and genetic studies of samples obtained from 43 patients with gigantism and then sequenced an implicated gene in samples from 248 patients with acromegaly. We observed microduplication on chromosome Xq26.3 in samples from 13 patients with gigantism; of these samples, 4 were obtained from members of two unrelated kindreds, and 9 were from patients with sporadic cases. All the patients had disease onset during early childhood. Of the patients with gigantism who did not carry an Xq26.3 microduplication, none presented before the age of 5 years. Genomic characterization of the Xq26.3 region suggests that the microduplications are generated during chromosome replication and that they contain four protein-coding genes. Only one of these genes, GPR101, which encodes a G-protein-coupled receptor, was overexpressed in patients' pituitary lesions. We identified a recurrent GPR101 mutation (p.E308D) in 11 of 248 patients with acromegaly, with the mutation found mostly in tumors. When the mutation was transfected into rat GH3 cells, it led to increased release of growth hormone and proliferation of growth hormone-producing cells. We describe a pediatric disorder (which we have termed X-linked acrogigantism [X-LAG]) that is caused by an Xq26.3 genomic duplication and is characterized by early-onset gigantism resulting from an excess of growth hormone. Duplication of GPR101 probably causes X-LAG. We also found a recurrent mutation in GPR101 in some adults with acromegaly. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and others.).
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Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation
Trivellin, G.; Daly, A.F.; Faucz, F.R.; Yuan, B.; Rostomyan, L.; Larco, D.O.; Schernthaner-Reiter, M.H.; Szarek, E.; Leal, L.F.; Caberg, J.-H.; Castermans, E.; Villa, C.; Dimopoulos, A.; Chittiboina, P.; Xekouki, P.; Shah, N.; Metzger, D.; Lysy, P.A.; Ferrante, E.; Strebkova, N.; Mazerkina, N.; Zatelli, M.C.; Lodish, M.; Horvath, A.; de Alexandre, R. Bertollo; Manning, A.D.; Levy, I.; Keil, M.F.; de la Luz Sierra, M.; Palmeira, L.; Coppieters, W.; Georges, M.; Naves, L.A.; Jamar, M.; Bours, V.; Wu, T.J.; Choong, C.S.; Bertherat, J.; Chanson, P.; Kamenický, P.; Farrell, W.E.; Barlier, A.; Quezado, M.; Bjelobaba, I.; Stojilkovic, S.S.; Wess, J.; Costanzi, S.; Liu, P.; Lupski, J.R.; Beckers, A.; Stratakis, C.A.
2015-01-01
BACKGROUND Increased secretion of growth hormone leads to gigantism in children and acromegaly in adults; the genetic causes of gigantism and acromegaly are poorly understood. METHODS We performed clinical and genetic studies of samples obtained from 43 patients with gigantism and then sequenced an implicated gene in samples from 248 patients with acromegaly. RESULTS We observed microduplication on chromosome Xq26.3 in samples from 13 patients with gigantism; of these samples, 4 were obtained from members of two unrelated kindreds, and 9 were from patients with sporadic cases. All the patients had disease onset during early childhood. Of the patients with gigantism who did not carry an Xq26.3 microduplication, none presented before the age of 5 years. Genomic characterization of the Xq26.3 region suggests that the microduplications are generated during chromosome replication and that they contain four protein-coding genes. Only one of these genes, GPR101, which encodes a G-protein–coupled receptor, was overexpressed in patients’ pituitary lesions. We identified a recurrent GPR101 mutation (p.E308D) in 11 of 248 patients with acromegaly, with the mutation found mostly in tumors. When the mutation was transfected into rat GH3 cells, it led to increased release of growth hormone and proliferation of growth hormone–producing cells. CONCLUSIONS We describe a pediatric disorder (which we have termed X-linked acrogigantism [X-LAG]) that is caused by an Xq26.3 genomic duplication and is characterized by early-onset gigantism resulting from an excess of growth hormone. Duplication of GPR101 probably causes X-LAG. We also found a recurrent mutation in GPR101 in some adults with acromegaly. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and others.) PMID:25470569
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A genetic basis for functional hypothalamic amenorrhea.
Caronia, Lisa M; Martin, Cecilia; Welt, Corrine K; Sykiotis, Gerasimos P; Quinton, Richard; Thambundit, Apisadaporn; Avbelj, Magdalena; Dhruvakumar, Sadhana; Plummer, Lacey; Hughes, Virginia A; Seminara, Stephanie B; Boepple, Paul A; Sidis, Yisrael; Crowley, William F; Martin, Kathryn A; Hall, Janet E; Pitteloud, Nelly
2011-01-20
Functional hypothalamic amenorrhea is a reversible form of gonadotropin-releasing hormone (GnRH) deficiency commonly triggered by stressors such as excessive exercise, nutritional deficits, or psychological distress. Women vary in their susceptibility to inhibition of the reproductive axis by such stressors, but it is unknown whether this variability reflects a genetic predisposition to hypothalamic amenorrhea. We hypothesized that mutations in genes involved in idiopathic hypogonadotropic hypogonadism, a congenital form of GnRH deficiency, are associated with hypothalamic amenorrhea. We analyzed the coding sequence of genes associated with idiopathic hypogonadotropic hypogonadism in 55 women with hypothalamic amenorrhea and performed in vitro studies of the identified mutations. Six heterozygous mutations were identified in 7 of the 55 patients with hypothalamic amenorrhea: two variants in the fibroblast growth factor receptor 1 gene FGFR1 (G260E and R756H), two in the prokineticin receptor 2 gene PROKR2 (R85H and L173R), one in the GnRH receptor gene GNRHR (R262Q), and one in the Kallmann syndrome 1 sequence gene KAL1 (V371I). No mutations were found in a cohort of 422 controls with normal menstrual cycles. In vitro studies showed that FGFR1 G260E, FGFR1 R756H, and PROKR2 R85H are loss-of-function mutations, as has been previously shown for PROKR2 L173R and GNRHR R262Q. Rare variants in genes associated with idiopathic hypogonadotropic hypogonadism are found in women with hypothalamic amenorrhea, suggesting that these mutations may contribute to the variable susceptibility of women to the functional changes in GnRH secretion that characterize hypothalamic amenorrhea. Our observations provide evidence for the role of rare variants in common multifactorial disease. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and others; ClinicalTrials.gov number, NCT00494169.).
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Strategic Planning for Research in Pediatric Critical Care.
Tamburro, Robert F; Jenkins, Tammara L; Kochanek, Patrick M
2016-11-01
To summarize the scientific priorities and potential future research directions for pediatric critical care research discussed by a panel of experts at the inaugural Strategic Planning Conference of the Pediatric Trauma and Critical Illness Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Expert opinion expressed during the Strategic Planning Conference. Not applicable. Chaired by an experienced expert from the field, issues relevant to the conduct of pediatric critical care research were discussed and debated by the invited participants. Common themes and suggested priorities were identified and coalesced. Of the many pathophysiologic conditions discussed, the multiple organ dysfunction syndrome emerged as a topic in need of more study that is most relevant to the field. Additionally, the experts offered that the interrelationship and impact of critical illness on child development and family functioning are important research priorities. Consequently, long-term outcomes research was encouraged. The expert group also suggested that multidisciplinary conferences are needed to help identify key knowledge gaps to advance and direct research in the field. The Pediatric Critical Care and Trauma Scientist Development National K12 Program and the Collaborative Pediatric Critical Care Research Network were recognized as successful and important programs supported by the branch. The development of core data resources including biorepositories with robust phenotypic data using common data elements was also suggested to foster data sharing among investigators and to enhance disease diagnosis and discovery. Multicenter clinical trials and innovative study designs to address understudied and poorly understood conditions were considered important for field advancement. Finally, the growth of the pediatric critical care research workforce was offered as a priority that could be spawned in many ways including by expanded
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Neonatal Glycemia and Neurodevelopmental Outcomes at 2 Years.
McKinlay, Christopher J D; Alsweiler, Jane M; Ansell, Judith M; Anstice, Nicola S; Chase, J Geoffrey; Gamble, Gregory D; Harris, Deborah L; Jacobs, Robert J; Jiang, Yannan; Paudel, Nabin; Signal, Matthew; Thompson, Benjamin; Wouldes, Trecia A; Yu, Tzu-Ying; Harding, Jane E
2015-10-15
Neonatal hypoglycemia is common and can cause neurologic impairment, but evidence supporting thresholds for intervention is limited. We performed a prospective cohort study involving 528 neonates with a gestational age of at least 35 weeks who were considered to be at risk for hypoglycemia; all were treated to maintain a blood glucose concentration of at least 47 mg per deciliter (2.6 mmol per liter). We intermittently measured blood glucose for up to 7 days. We continuously monitored interstitial glucose concentrations, which were masked to clinical staff. Assessment at 2 years included Bayley Scales of Infant Development III and tests of executive and visual function. Of 614 children, 528 were eligible, and 404 (77% of eligible children) were assessed; 216 children (53%) had neonatal hypoglycemia (blood glucose concentration, <47 mg per deciliter). Hypoglycemia, when treated to maintain a blood glucose concentration of at least 47 mg per deciliter, was not associated with an increased risk of the primary outcomes of neurosensory impairment (risk ratio, 0.95; 95% confidence interval [CI], 0.75 to 1.20; P=0.67) and processing difficulty, defined as an executive-function score or motion coherence threshold that was more than 1.5 SD from the mean (risk ratio, 0.92; 95% CI, 0.56 to 1.51; P=0.74). Risks were not increased among children with unrecognized hypoglycemia (a low interstitial glucose concentration only). The lowest blood glucose concentration, number of hypoglycemic episodes and events, and negative interstitial increment (area above the interstitial glucose concentration curve and below 47 mg per deciliter) also did not predict the outcome. In this cohort, neonatal hypoglycemia was not associated with an adverse neurologic outcome when treatment was provided to maintain a blood glucose concentration of at least 47 mg per deciliter. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and others.).
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Identification of extremely premature infants at high risk of rehospitalization.
Ambalavanan, Namasivayam; Carlo, Waldemar A; McDonald, Scott A; Yao, Qing; Das, Abhik; Higgins, Rosemary D
2011-11-01
Extremely low birth weight infants often require rehospitalization during infancy. Our objective was to identify at the time of discharge which extremely low birth weight infants are at higher risk for rehospitalization. Data from extremely low birth weight infants in Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network centers from 2002-2005 were analyzed. The primary outcome was rehospitalization by the 18- to 22-month follow-up, and secondary outcome was rehospitalization for respiratory causes in the first year. Using variables and odds ratios identified by stepwise logistic regression, scoring systems were developed with scores proportional to odds ratios. Classification and regression-tree analysis was performed by recursive partitioning and automatic selection of optimal cutoff points of variables. A total of 3787 infants were evaluated (mean ± SD birth weight: 787 ± 136 g; gestational age: 26 ± 2 weeks; 48% male, 42% black). Forty-five percent of the infants were rehospitalized by 18 to 22 months; 14.7% were rehospitalized for respiratory causes in the first year. Both regression models (area under the curve: 0.63) and classification and regression-tree models (mean misclassification rate: 40%-42%) were moderately accurate. Predictors for the primary outcome by regression were shunt surgery for hydrocephalus, hospital stay of >120 days for pulmonary reasons, necrotizing enterocolitis stage II or higher or spontaneous gastrointestinal perforation, higher fraction of inspired oxygen at 36 weeks, and male gender. By classification and regression-tree analysis, infants with hospital stays of >120 days for pulmonary reasons had a 66% rehospitalization rate compared with 42% without such a stay. The scoring systems and classification and regression-tree analysis models identified infants at higher risk of rehospitalization and might assist planning for care after discharge.
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Early Onset Neonatal Sepsis: The Burden of Group B Streptococcal and E. coli Disease Continues
Hansen, Nellie I.; Sánchez, Pablo J.; Faix, Roger G.; Poindexter, Brenda B.; Van Meurs, Krisa P.; Bizzarro, Matthew J.; Goldberg, Ronald N.; Frantz, Ivan D.; Hale, Ellen C.; Shankaran, Seetha; Kennedy, Kathleen; Carlo, Waldemar A.; Watterberg, Kristi L.; Bell, Edward F.; Walsh, Michele C.; Schibler, Kurt; Laptook, Abbot R.; Shane, Andi L.; Schrag, Stephanie J.; Das, Abhik; Higgins, Rosemary D.
2011-01-01
BACKGROUND: Guidelines for prevention of group B streptococcal (GBS) infection have successfully reduced early onset (EO) GBS disease. Study results suggest that Escherichia coli is an important EO pathogen. OBJECTIVE: To determine EO infection rates, pathogens, morbidity, and mortality in a national network of neonatal centers. METHODS: Infants with EO infection were identified by prospective surveillance at Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Network centers. Infection was defined by positive culture results for blood and cerebrospinal fluid obtained from infants aged ≤72 hours plus treatment with antibiotic therapy for ≥5 days. Mother and infant characteristics, treatments, and outcomes were studied. Numbers of cases and total live births (LBs) were used to calculate incidence. RESULTS: Among 396 586 LBs (2006–2009), 389 infants developed EO infection (0.98 cases per 1000 LBs). Infection rates increased with decreasing birth weight. GBS (43%, 0.41 per 1000 LBs) and E coli (29%, 0.28 per 1000 LBs) were most frequently isolated. Most infants with GBS were term (73%); 81% with E coli were preterm. Mothers of 67% of infected term and 58% of infected preterm infants were screened for GBS, and results were positive for 25% of those mothers. Only 76% of mothers with GBS colonization received intrapartum chemoprophylaxis. Although 77% of infected infants required intensive care, 20% of term infants were treated in the normal newborn nursery. Sixteen percent of infected infants died, most commonly with E coli infection (33%). CONCLUSION: In the era of intrapartum chemoprophylaxis to reduce GBS, rates of EO infection have declined but reflect a continued burden of disease. GBS remains the most frequent pathogen in term infants, and E coli the most significant pathogen in preterm infants. Missed opportunities for GBS prevention continue. Prevention of E coli sepsis, especially among preterm infants, remains a
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Strategic Planning for Research in Pediatric Critical Care
Tamburro, Robert F.; Jenkins, Tammara L.; Kochanek, Patrick M.
2016-01-01
Objective To summarize the scientific priorities and potential future research directions for pediatric critical care research discussed by a panel of experts at the inaugural Strategic Planning Conference of the Pediatric Trauma and Critical Illness Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Data Sources Expert opinion expressed during the Strategic Planning Conference. Study Selection Not applicable Data Extraction Chaired by an experienced expert from the field, issues relevant to the conduct of pediatric critical care research were discussed and debated by the invited participants. Data Synthesis Common themes and suggested priorities were identified and coalesced. Conclusions Of the many pathophysiological conditions discussed, the multiple organ dysfunction syndrome emerged as a topic in need of more study that is most relevant to the field. Additionally, the experts offered that the inter-relationship and impact of critical illness on child development and family functioning are important research priorities. Consequently, long-term outcomes research was encouraged. The expert group also suggested that multidisciplinary conferences are needed to help identify key knowledge gaps to advance and direct research in the field. The Pediatric Critical Care and Trauma Scientist Development National K12 Program and the Collaborative Pediatric Critical Care Research Network were recognized as successful and important programs supported by the branch. The development of core data resources including biorepositories with robust phenotypic data using common data elements was also suggested to foster data sharing among investigators and to enhance disease diagnosis and discovery. Multicenter clinical trials and innovative study designs to address understudied and poorly understood conditions were considered important for field advancement. Finally, the growth of the pediatric critical care research workforce was offered
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Identification of Extremely Premature Infants at High Risk of Rehospitalization
Carlo, Waldemar A.; McDonald, Scott A.; Yao, Qing; Das, Abhik; Higgins, Rosemary D.
2011-01-01
OBJECTIVE: Extremely low birth weight infants often require rehospitalization during infancy. Our objective was to identify at the time of discharge which extremely low birth weight infants are at higher risk for rehospitalization. METHODS: Data from extremely low birth weight infants in Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network centers from 2002–2005 were analyzed. The primary outcome was rehospitalization by the 18- to 22-month follow-up, and secondary outcome was rehospitalization for respiratory causes in the first year. Using variables and odds ratios identified by stepwise logistic regression, scoring systems were developed with scores proportional to odds ratios. Classification and regression-tree analysis was performed by recursive partitioning and automatic selection of optimal cutoff points of variables. RESULTS: A total of 3787 infants were evaluated (mean ± SD birth weight: 787 ± 136 g; gestational age: 26 ± 2 weeks; 48% male, 42% black). Forty-five percent of the infants were rehospitalized by 18 to 22 months; 14.7% were rehospitalized for respiratory causes in the first year. Both regression models (area under the curve: 0.63) and classification and regression-tree models (mean misclassification rate: 40%–42%) were moderately accurate. Predictors for the primary outcome by regression were shunt surgery for hydrocephalus, hospital stay of >120 days for pulmonary reasons, necrotizing enterocolitis stage II or higher or spontaneous gastrointestinal perforation, higher fraction of inspired oxygen at 36 weeks, and male gender. By classification and regression-tree analysis, infants with hospital stays of >120 days for pulmonary reasons had a 66% rehospitalization rate compared with 42% without such a stay. CONCLUSIONS: The scoring systems and classification and regression-tree analysis models identified infants at higher risk of rehospitalization and might assist planning for care after
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Zero Robotics at Kennedy Space Center Visitor Complex
2017-08-11
NASA Kennedy Space Center's Trent Smith conducts a quantum levitation demonstration, using liquid nitrogen, metal and a magnetic track, for students and their sponsors in the Center for Space Education at NASA’s Kennedy Space Center in Florida. Teams from across the state of Florida were gathered at Kennedy for the finals of the Zero Robotics Middle School Summer Program national championship. The five-week program allows rising sixth- through ninth-graders to write programs for small satellites called SPHERES (Synchronized, Position, Hold, Engage, Reorient, Experimental Satellites). Finalists saw their code tested aboard the International Space Station.
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50th anniversary of the inauguration of John F. Kennedy
2011-01-20
NASA Administrator Charles Bolden. 3rd from left, introduces Edward Moore Kennedy III, 4th from left, to NASA Astronaut Leland Melvin, left, and former NASA Astronaut Scott Altman, 2nd from left, as Edward's mother Kiki Kennedy, wife of Edward M Kennedy Jr. and NASA Deputy Administrator Lori Garver, right, look on at an event recognizing the 50th anniversary of the inauguration of John F. Kennedy as president of the United States, Thursday, Jan. 20, 2001 at the U.S. Capitol rotunda. Photo Credit: (NASA/Bill Ingalls)
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Kennedy Space Center Timing and Countdown Interface to Kennedy Ground Control Subsystem
NASA Technical Reports Server (NTRS)
Olsen, James C.
2015-01-01
Kennedy Ground Control System (KGCS) engineers at the National Aeronautics and Space Administration (NASA) Kennedy Space Center (KSC) are developing a time-tagging process to enable reconstruction of the events during a launch countdown. Such a process can be useful in the case of anomalies or other situations where it is necessary to know the exact time an event occurred. It is thus critical for the timing information to be accurate. KGCS will synchronize all items with Coordinated Universal Time (UTC) obtained from the Timing and Countdown (T&CD) organization. Network Time Protocol (NTP) is the protocol currently in place for synchronizing UTC. However, NTP has a peak error that is too high for today's standards. Precision Time Protocol (PTP) is a newer protocol with a much smaller peak error. The focus of this project has been to implement a PTP solution on the network to increase timing accuracy while introducing and configuring the implementation of a firewall between T&CD and the KGCS network.
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
Air Force Two, carrying Vice President Mike Pence, taxis on the Shuttle Landing Facility at NASA's Kennedy Space Center in Florida. During his visit to Kennedy, the Vice President spoke inside the iconic Vehicle Assembly Building, where he thanked employees for advancing American leadership in space.
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
NASA's Acting Administrator Robert Lightfoot, left, greets Vide President Mike Pence at the Shuttle Landing Facility at the agency's Kennedy Space Center in Florida. During his visit to Kennedy, the Vice President spoke inside the iconic Vehicle Assembly Building, where he thanked employees for advancing American leadership in space.
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Pugh, Sarah J; Albert, Paul S; Kim, Sungduk; Grobman, William; Hinkle, Stefanie N; Newman, Roger B; Wing, Deborah A; Grantz, Katherine L
2017-09-01
Inadequate or excessive total gestational weight gain is associated with increased risks of small- and large-for-gestational-age births, respectively, but evidence is sparse regarding overall and trimester-specific patterns of gestational weight gain in relation to these risks. Characterizing the interrelationship between patterns of gestational weight gain across trimesters can reveal whether the trajectory of gestational weight gain in the first trimester sets the path for gestational weight gain in subsequent trimesters, thereby serving as an early marker for at-risk pregnancies. We sought to describe overall trajectories of gestational weight gain across gestation and assess the risk of adverse birthweight outcomes associated with the overall trajectory and whether the timing of gestational weight gain (first vs second/third trimester) is differentially associated with adverse outcomes. We conducted a secondary analysis of a prospective cohort of 2802 singleton pregnancies from 12 US prenatal centers (2009 through 2013). Small and large for gestational age were calculated using sex-specific birthweight references <5th, <10th, or ≥90th percentiles, respectively. At each of the research visits, women's weight was measured following a standardized anthropometric protocol. Maternal weight at antenatal clinical visits was also abstracted from the prenatal records. Semiparametric, group-based, latent class, trajectory models estimated overall gestational weight gain and separate first- and second-/third-trimester trajectories to assess tracking. Robust Poisson regression was used to estimate the relative risk of small- and large-for-gestational-age outcomes by the probability of trajectory membership. We tested whether relationships were modified by prepregnancy body mass index. There were 2779 women with a mean of 15 (SD 5) weights measured across gestation. Four distinct gestational weight gain trajectories were identified based on the lowest Bayesian information criterion value, classifying 10.0%, 41.8%, 39.2%, and 9.0% of the population from lowest to highest weight gain trajectories, with an inflection at 14 weeks. The average rate in each trajectory group from lowest to highest for 0-<14 weeks was -0.20, 0.04, 0.21, and 0.52 kg/wk and for 14-39 weeks was 0.29, 0.48, 0.63, and 0.79 kg/wk, respectively; the second lowest gaining trajectory resembled the Institute of Medicine recommendations and was designated as the reference with the other trajectories classified as low, moderate-high, or high. Accuracy of assignment was assessed and found to be high (median posterior probability 0.99, interquartile range 0.99-1.00). Compared with the referent trajectory, a low overall trajectory, but not other trajectories, was associated with a 1.55-fold (95% confidence interval, 1.06-2.25) and 1.58-fold (95% confidence interval, 0.88-2.82) increased risk of small-for-gestational-age <10th and <5th, respectively, while a moderate-high and high trajectory were associated with a 1.78-fold (95% confidence interval, 1.31-2.41) and 2.45-fold (95% confidence interval, 1.66-3.61) increased risk of large for gestational age, respectively. In a separate analysis investigating whether early (<14 weeks) gestational weight gain tracked with later (≥14 weeks) gestational weight gain, only 49% (n = 127) of women in the low first-trimester trajectory group continued as low in the second/third trimester, and had a 1.59-fold increased risk of small for gestational age; for the other 51% (n = 129) of women without a subsequently low second-/third-trimester gestational weight gain trajectory, there was no increased risk of small for gestational age (relative risk, 0.75; 95% confidence interval, 0.47-1.38). Prepregnancy body mass index did not modify the association between gestational weight gain trajectory and small for gestational age (P = 0.52) or large for gestational age (P = .69). Our findings are reassuring for women who experience weight loss or excessive weight gain in the first trimester; however, the risk of small or large for gestational age is significantly increased if women gain weight below or above the reference trajectory in the second/third trimester. Published by Elsevier Inc.
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Ground winds for Kennedy Space Center, Florida, 1979 revision
NASA Technical Reports Server (NTRS)
Johnson, D. L.; Brown, S. C.
1979-01-01
Revised ground-level runway wind statistics for the Kennedy Space Center, Florida area are presented. Crosswind, headwind, tailwind, and headwind reversal percentage frequencies are given with respect to month and hour for the Kennedy Space Center Space Shuttle runway.
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Kennedy Marks 20th Anniversary of Cassini Arrival
2017-04-20
NASA's Cassini spacecraft arrived at Kennedy Space Center 20 years ago to begin processing for launch on a mission that would see it deliver spectacular images and data from the ringed planet Saturn. As the massive spacecraft begins its final chapter, engineers at Kennedy took a look back to how their contributions to the mission began.
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
Vice President Mike Pence, left, waves as he and Sen. Marco Rubio of Florida arrive aboard Air Force Two at the Shuttle Landing Facility at NASA's Kennedy Space Center in Florida. During his visit to Kennedy, the Vice President spoke inside the iconic Vehicle Assembly Building, where he thanked employees for advancing American leadership in space.
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WILDLIFE - ALLIGATOR BEGINS TO CROSS KENNEDY PARKWAY
NASA Technical Reports Server (NTRS)
1969-01-01
Harold O'Connor, manager of the Merritt Island Wildlife Refuge, watches a 10-foot-long alligator inch its way toward a busy highway at the Kennedy Space Center. O'Connor, aided by assistant Jerome Carroll, not shown, guided the large gator to safety in a nearby pond, several miles south of the Vehicle Assembly Building, in background. The Apollo 12 astronauts will be launched no earlier than November 14, 1969, from the Kennedy Space Center on the Nation's second manned lunar landing mission.
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
Vice President Mike Pence arrives at the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. During his visit, Pence spoke inside the iconic building, where he thanked employees for advancing American leadership in space. The Vice President also toured several facilities highlighting the public-private partnerships at Kennedy, as both NASA and commercial companies prepare to launch American astronauts from the multi-user spaceport.
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Changes of pituitary gland volume in Kennedy disease.
Pieper, C C; Teismann, I K; Konrad, C; Heindel, W L; Schiffbauer, H
2013-12-01
Kennedy disease is a rare X-linked neurodegenerative disorder caused by a CAG repeat expansion in the first exon of the androgen-receptor gene. Apart from neurologic signs, this mutation can cause a partial androgen insensitivity syndrome with typical alterations of gonadotropic hormones produced by the pituitary gland. The aim of the present study was therefore to evaluate the impact of Kennedy disease on pituitary gland volume under the hypothesis that endocrinologic changes caused by partial androgen insensitivity may lead to morphologic changes (ie, hypertrophy) of the pituitary gland. Pituitary gland volume was measured in sagittal sections of 3D T1-weighted 3T-MR imaging data of 8 patients with genetically proven Kennedy disease and compared with 16 healthy age-matched control subjects by use of Multitracer by a blinded, experienced radiologist. The results were analyzed by a univariant ANOVA with total brain volume as a covariant. Furthermore, correlation and linear regression analyses were performed for pituitary volume, patient age, disease duration, and CAG repeat expansion length. Intraobserver reliability was evaluated by means of the Pearson correlation coefficient. Pituitary volume was significantly larger in patients with Kennedy disease (636 [±90] mm(3)) than in healthy control subjects (534 [±91] mm(3)) (P = .041). There was no significant difference in total brain volume (P = .379). Control subjects showed a significant decrease in volume with age (r = -0.712, P = .002), whereas there was a trend to increasing gland volume in patients with Kennedy disease (r = 0.443, P = .272). Gland volume correlated with CAG repeat expansion length in patients (r = 0.630, P = .047). The correlation coefficient for intraobserver reliability was 0.94 (P < .001). Patients with Kennedy disease showed a significantly higher pituitary volume that correlated with the CAG repeat expansion length. This could reflect hypertrophy as the result of elevated gonadotropic
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Health services at the Kennedy Space Center
NASA Technical Reports Server (NTRS)
Ferguson, E. B.; Humbert, P.; Long, I. D.; Tipton, D. A.
1992-01-01
Comprehensive occupational health services are provided to approximately 17,000 workers at the Kennedy Space Center and an additional 6000 on Cape Canaveral Air Force Station. These areas cover about 120,000 acres encompassing part of the Merritt Island Wild Life Refuge and wetlands which are the habitat of numerous endangered and protected species of wildlife. The services provided at the Kennedy Space Center optimally assure a safe and healthy working environment for the employees engaged in the preparation and launching of this country's Space Shuttle and other important space exploration programs.
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Kennedy Space Center Payload Processing
NASA Technical Reports Server (NTRS)
Lawson, Ronnie; Engler, Tom; Colloredo, Scott; Zide, Alan
2011-01-01
This slide presentation reviews the payload processing functions at Kennedy Space Center. It details some of the payloads processed at KSC, the typical processing tasks, the facilities available for processing payloads, and the capabilities and customer services that are available.
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Ground winds for Kennedy Space Center, Florida (1978 version)
NASA Technical Reports Server (NTRS)
Johnson, D. L.; Brown, S. C.
1978-01-01
Ground level runway wind statistics are presented for the Kennedy Space Center, Florida area. Crosswind, headwind, tailwind, and headwind reversal percentage frequencies are given with respect to month and hour for the Kennedy Space Center Space Shuttle runway. This document supersedes NASA CR-128995 and should be used in place of it.
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Wind data from Kennedy Airport
DOT National Transportation Integrated Search
1997-06-01
A 700-foot array of horizontal and vertical single-axle anemometers was installed at New York's Kennedy Airport on 30-foot poles under the approach to Runway 31R. One-minute average measurements were recorded continuously, with a few breaks, from Sep...
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Kennedy Center Salute To Apollo
2009-07-17
The audience applauds during the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
NASA Kennedy Space Center Director Robert Cabana addresses agency leaders, U.S. and Florida government officials, and employees inside the Vehicle Assembly Building during a visit by Vice President Mike Pence. Pence thanked employees for advancing American leadership in space. During his visit to Kennedy, the Vice President also toured several facilities highlighting the public-private partnerships, as both NASA and commercial companies prepare to launch American astronauts from the multi-user spaceport.
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
Vice President Mike Pence speaks before an audience of NASA leaders, U.S. and Florida government officials, and employees inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. Pence thanked employees for advancing American leadership in space. During his visit to Kennedy, the Vice President also toured several facilities highlighting the public-private partnerships, as both NASA and commercial companies prepare to launch American astronauts from the multi-user spaceport.
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Kennedy Center Salute To Apollo
2009-07-17
Opera singer Denyce Graves sings during the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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Kennedy Center Salute To Apollo
2009-07-17
Singer Chaka Khan performs during the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
Vice President Mike Pence, back to the camera, is greeted by NASA officials at the Shuttle Landing Facility at NASA's Kennedy Space Center in Florida. From the left are, Deputy Center Director Janet Petro, Center Director Bob Cabana and Acting Administrator Robert Lightfoot. To the right of Lightfoot is Sen. Marco Rubio of Florida. During his visit to Kennedy, the Vice President spoke inside the iconic Vehicle Assembly Building, where he thanked employees for advancing American leadership in space.
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
Upon his arrival at NASA's Kennedy Space Center in Florida, Vice President Mike Pence, back to the camera, is greeted by Deputy Center Director Janet Petro. Behind the Vice President, Sen. Marco Rubio of Florida, shakes hands with Center Director Bob Cabana. To the right of Cabana is Acting NASA Administrator Robert Lightfoot. During his visit to Kennedy, the Vice President spoke inside the iconic Vehicle Assembly Building, where he thanked employees for advancing American leadership in space.
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Kennedy Center Salute To Apollo
2009-07-17
12 year old singer Jamia Nash performs during the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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Ackroyd, Dame Elizabeth
1981-01-01
I welcome Mr Kennedy's general approach, but query whether the concept of consumerism is so closely applicable to medical care as he maintains. However, in particular aspects, especially the handling of complaints, his criticisms echo those made by the Patients Association. Finally, I detect some ground for hope in the more enlightened attitude creeping in to the eduction of the medical student. PMID:7334491
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2008-05-03
CAPE CANAVERAL, Fla. -- Former astronaut Robert Cabana (center) receives congratulations on his induction into the U.S. Astronaut Hall of Fame from former inductees Al Worden (left) and Michael Coats (right). Other inductees were John Blaha, Loren Shriver; and Bryan O'Connor, NASA's chief of Safety and Mission Assurance at NASA Headquarters in Washington. Other former astronauts attending included Scott Carpenter, John Young, Bob Crippen, and Walt Cunningham. The U.S. Astronaut Hall of Fame is operated by Kennedy Space Center Visitor Complex on behalf of NASA. CNN correspondent John Zarrella hosted the event.
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
Kennedy Space Center Bob Cabana, left, and NASA's Acting Administrator Robert Lightfoot, right present Vice President Mike Pence with a framed plaque. On the back of the plaque are patches from each of Cabana's four space shuttle mission, STS-88, STS-53, STS-65, STS-41, and an inscription thanking the Vice President for his support of NASA. During his visit to Kennedy, the Vice President spoke inside the iconic Vehicle Assembly Building, where he thanked employees for advancing American leadership in space.
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Zero Robotics at Kennedy Space Center Visitor Complex
2017-08-11
NASA Kennedy Space Center Associate Director Kelvin Manning speaks to students and sponsors in the spaceport’s Center for Space Education. Teams from across the state of Florida were gathered at Kennedy for the finals of the Zero Robotics Middle School Summer Program national championship. The five-week program allows rising sixth- through ninth-graders to write programs for small satellites called SPHERES (Synchronized, Position, Hold, Engage, Reorient, Experimental Satellites). Finalists saw their code tested aboard the International Space Station.
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Kennedy Center Salute To Apollo
2009-07-17
Emil de Cou conducts the National Symphony Orchestra during the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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2003-10-15
KENNEDY SPACE CENTER, FLA. - Center Director Jim Kennedy (center) shares the kudos for Spaceport Super Safety and Health Day with members of the coordinating committee. Astronaut Barry E. Wilmore (at right) presented the award to Kennedy. Next to Wilmore at right is Dr. Woodrow Whitlow, KSC’s deputy director.
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Kennedy Center Salute To Apollo
2009-07-17
Members of the U.S. Army Chorus and Alumni sing during the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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Improved Kennedy-Thorndike experiment to test special relativity
NASA Technical Reports Server (NTRS)
Hils, Dieter; Hall, J. L.
1990-01-01
A modern version of the Kennedy-Thorndike experiment was carried out by searching for sidereal variations between the frequency of a laser locked to an I2 reference line and a laser locked to the resonance frequency of a highly stable cavity. No variations were found at the level of 2 x 10 to the -12th. This represents a 300-fold improvement over the original Kennedy-Thorndike experiment and allows the Lorentz transformations to be deduced entirely from experiment at an accuracy level of 70 ppm.
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Improved Kennedy-Thorndike experiment to test special relativity
NASA Astrophysics Data System (ADS)
Hils, Dieter; Hall, J. L.
1990-04-01
A modern version of the Kennedy-Thorndike experiment was carried out by searching for sidereal variations between the frequency of a laser locked to an I2 reference line and a laser locked to the resonance frequency of a highly stable cavity. No variations were found at the level of 2 x 10 to the -12th. This represents a 300-fold improvement over the original Kennedy-Thorndike experiment and allows the Lorentz transformations to be deduced entirely from experiment at an accuracy level of 70 ppm.
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Zero Robotics at Kennedy Space Center Visitor Complex
2017-08-11
Students and sponsors hear from astronauts aboard the International Space Station on a big screen in the Center for Space Education at NASA’s Kennedy Space Center in Florida. Teams from across the state of Florida were gathered at Kennedy for the finals of the Zero Robotics Middle School Summer Program national championship. The five-week program allows rising sixth- through ninth-graders to write programs for small satellites called SPHERES (Synchronized, Position, Hold, Engage, Reorient, Experimental Satellites). Finalists saw their code tested aboard the orbiting laboratory.
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50th anniversary of the inauguration of John F. Kennedy
2011-01-20
Caroline Kennedy speaks at an event recognizing the 50th anniversary of the inauguration of John F. Kennedy as President of the United States and where the website jfk50.org was unveiled, Thursday, Jan. 20, 2011 at the Russell Senate Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)
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President Kennedy's Speech at Rice University
NASA Technical Reports Server (NTRS)
1988-01-01
This video tape presents unedited film footage of President John F. Kennedy's speech at Rice University, Houston, Texas, September 12, 1962. The speech expresses the commitment of the United States to landing an astronaut on the Moon.
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Kennedy Center Salute To Apollo
2009-07-17
Emil de Cou, Conductor of the National Symphony Orchestra, talks to the audience during the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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Kennedy Center Salute To Apollo
2009-07-17
Members of the National Symphony Orchestra, under Conductor Emil de Cou, perform during the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
Vice President Mike Pence speaks before an audience of NASA leaders, U.S. and Florida government officials, and employees inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. Pence thanked employees for advancing American leadership in space. Behind the podium is the Orion spacecraft flown on Exploration Flight test-1 in 2014. During his visit to Kennedy, the Vice President also toured several facilities highlighting the public-private partnerships, as both NASA and commercial companies prepare to launch American astronauts from the multi-user spaceport.
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
Kennedy Space Center Bob Cabana, left, and NASA's Acting Administrator Robert Lightfoot, right present Vice President Mike Pence with a framed plaque. At the top is an illustration featuring NASA's efforts to explore Mars. Also included is the flag of the Vice President's home state of Indiana that was flown on the SpaceX Commercial Resupply Services-10 flight in February and March this year. During his visit to Kennedy, the Vice President spoke inside the iconic Vehicle Assembly Building, where he thanked employees for advancing American leadership in space.
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Zero Robotics at Kennedy Space Center Visitor Complex
2017-08-11
Darth Vader and other Star Wars characters from the 501st Legion address students and sponsors in the Center for Space Education at NASA’s Kennedy Space Center in Florida. Teams from across the state of Florida were gathered at Kennedy for the finals of the Zero Robotics Middle School Summer Program national championship. The five-week program allows rising sixth- through ninth-graders to write programs for small satellites called SPHERES (Synchronized, Position, Hold, Engage, Reorient, Experimental Satellites). Finalists saw their code tested aboard the International Space Station.
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Zero Robotics at Kennedy Space Center Visitor Complex
2017-08-11
A middle-school student high-fives a Star Wars character from the 501st Legion in the Center for Space Education at NASA’s Kennedy Space Center in Florida. Teams from across the state of Florida were gathered at Kennedy for the finals of the Zero Robotics Middle School Summer Program national championship. The five-week program allows rising sixth- through ninth-graders to write programs for small satellites called SPHERES (Synchronized, Position, Hold, Engage, Reorient, Experimental Satellites). Finalists saw their code tested aboard the International Space Station.
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Photocopy of drawing. VEHICLE ASSEMBLY BUILDING. NASA John F. Kennedy ...
Photocopy of drawing. VEHICLE ASSEMBLY BUILDING. NASA John F. Kennedy Space Center, Florida. File Number 79K06740, NASA, November 1975. SPACE & WEIGHT ALLOCATION, ORBITER PATH IN TRANSFER AISLE. Sheet 6 - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL
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Photocopy of drawing. LAUNCH COMPLEX 39. NASA, John F. Kennedy ...
Photocopy of drawing. LAUNCH COMPLEX 39. NASA, John F. Kennedy Space Center, Florida. File Number 203-100, Urbahn-Roberts-Seelye-Moran, October, 1963. LCC TRANSVERSE SECTIONS AA & BB. Sheet 29-45 - Cape Canaveral Air Force Station, Launch Complex 39, Launch Control Center, LCC Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL
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Kennedy Center Salute To Apollo
2009-07-17
Apollo 11 astronaut Buzz Aldrin reads an introduction to Gustav Holst: The Planets Suite during the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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Obama Kennedy Space Center Visit
2010-04-14
US Senator Bill Nelson (D-FL) gives introductory remarks during an event where President Barack Obama outlined a bold new course the administration is charting to maintain U.S. leadership in human space flight at the NASA Kennedy Space Center in Cape Canaveral, Fla. on Thursday, April 15, 2010. Photo Credit: (NASA/Bill Ingalls)
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Research and technology at Kennedy Space Center
NASA Technical Reports Server (NTRS)
1989-01-01
As the NASA Center responsible for assembly, checkout, servicing, launch, recovery, and operational support of Space Transportation System elements and payloads, Kennedy Space Center is placing increasing emphasis on the Center's research and technology program. In addition to strengthening those areas of engineering and operations technology that contribute to safer, more efficient, and more economical execution of current mission, the technical tools are developed needed to execute Center's mission relative to future programs. The Engineering Development Directorate encompasses most of the laboratories and other Center resources that are key elements of research and technology program implementation and is responsible for implementation of the majority of the projects in this Kennedy Space Center 1989 Annual Report.
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Photocopy of drawing. LAUNCH COMPLEX 39. NASA, John F. Kennedy ...
Photocopy of drawing. LAUNCH COMPLEX 39. NASA, John F. Kennedy Space Center, Florida. File Number 203-100, Urbahn-Roberts-Seelye-Moran, October, 1963. VOLUME 29, LAUNCH CONTROL CENTER (LCC) TITLE AND LOCATION SHEET. Sheet 29-01 - Cape Canaveral Air Force Station, Launch Complex 39, Launch Control Center, LCC Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL
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Kennedy Center Salute To Apollo
2009-07-17
Apollo 11 astronaut Buzz Aldrin, left, meets with Gene Kranz, retired NASA Flight Director and manager, back stage after the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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Kennedy Space Center Spaceport Analysis
NASA Technical Reports Server (NTRS)
Wary, Samantha A.
2013-01-01
Until the Shuttle Atlantis' final landing on July 21, 2011, Kennedy Space Center (KSC) served as NASA's main spaceport, which is a launch and landing facility for rockets and spacecraft that are attempting to enter orbit. Many of the facilities at KSC were created to assist the Shuttle Program. One of the most important and used facilities is the Shuttle Landing Facility (SLF), This was the main landing area for the return of the shuttle after her mission in space. · However, the SLF has also been used for a number of other projects including straight-line testing by Gibbs Racing, weather data collection by NOAA, and an airfield for the KSC helicopters. This runway is three miles long with control tower at midfield and a fire department located at the end in care of an emergency. This facility, which was part of the great space race, will continue to be used for historical events as Kennedy begins to commercialize its facilities. KSC continues to be an important spaceport to the government, and it will transform into an important spaceport for the commercial industry as well. During my internship at KSC's Center Planning and Development Directorate, I had the opportunity to be a part of the negotiation team working on the agreement for Space Florida to control the Shuttle Landing Facility. This gave me the opportunity to learn about all the changes that are occurring here at Kennedy Space Center. Through various meetings, I discovered the Master Plan and its focus is to transform the existing facilities that were primarily used for the Shuttle Program, to support government operations and commercial flights in the future. This. idea is also in a new strategic business plan and completion of a space industry market analysis. All of these different documentations were brought to my attention and I. saw how they came together in the discussions of transitioning the SLF to a commercial operator, Space Florida. After attending meetings and partaking in discussions for
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A Genetic Basis for Functional Hypothalamic Amenorrhea
Caronia, Lisa M.; Martin, Cecilia; Welt, Corrine K.; Sykiotis, Gerasimos P.; Quinton, Richard; Thambundit, Apisadaporn; Avbelj, Magdalena; Dhruvakumar, Sadhana; Plummer, Lacey; Hughes, Virginia A.; Seminara, Stephanie B.; Boepple, Paul A.; Sidis, Yisrael; Crowley, William F.; Martin, Kathryn A.; Hall, Janet E.; Pitteloud, Nelly
2011-01-01
BACKGROUND Functional hypothalamic amenorrhea is a reversible form of gonadotropin-releasing hormone (GnRH) deficiency commonly triggered by stressors such as excessive exercise, nutritional deficits, or psychological distress. Women vary in their susceptibility to inhibition of the reproductive axis by such stressors, but it is unknown whether this variability reflects a genetic predisposition to hypothalamic amenorrhea. We hypothesized that mutations in genes involved in idiopathic hypogonadotropic hypogonadism, a congenital form of GnRH deficiency, are associated with hypothalamic amenorrhea. METHODS We analyzed the coding sequence of genes associated with idiopathic hypogonadotropic hypogonadism in 55 women with hypothalamic amenorrhea and performed in vitro studies of the identified mutations. RESULTS Six heterozygous mutations were identified in 7 of the 55 patients with hypothalamic amenorrhea: two variants in the fibroblast growth factor receptor 1 gene FGFR1 (G260E and R756H), two in the prokineticin receptor 2 gene PROKR2 (R85H and L173R), one in the GnRH receptor gene GNRHR (R262Q), and one in the Kall-mann syndrome 1 sequence gene KAL1 (V371I). No mutations were found in a cohort of 422 controls with normal menstrual cycles. In vitro studies showed that FGFR1 G260E, FGFR1 R756H, and PROKR2 R85H are loss-of-function mutations, as has been previously shown for PROKR2 L173R and GNRHR R262Q. CONCLUSIONS Rare variants in genes associated with idiopathic hypogonadotropic hypogonadism are found in women with hypothalamic amenorrhea, suggesting that these mutations may contribute to the variable susceptibility of women to the functional changes in GnRH secretion that characterize hypothalamic amenorrhea. Our observations provide evidence for the role of rare variants in common multifactorial disease. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and others; ClinicalTrials.gov number, NCT00494169.) PMID:21247312
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Hartnett, M Elizabeth; Morrison, Margaux A; Smith, Silvia; Yanovitch, Tammy L; Young, Terri L; Colaizy, Tarah; Momany, Allison; Dagle, John; Carlo, Waldemar A; Clark, Erin A S; Page, Grier; Murray, Jeff; DeAngelis, Margaret M; Cotten, C Michael
2014-08-12
To determine genetic variants associated with severe retinopathy of prematurity (ROP) in a candidate gene cohort study of US preterm infants. Preterm infants in the discovery cohort were enrolled through the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, and those in the replication cohort were from the University of Iowa. All infants were phenotyped for ROP severity. Because of differences in the durations of enrollment between cohorts, severe ROP was defined as threshold disease in the discovery cohort and as threshold disease or type 1 ROP in the replication cohort. Whole genome amplified DNA from stored blood spot samples from the Neonatal Research Network biorepository was genotyped using an Illumina GoldenGate platform for candidate gene single nucleotide polymorphisms (SNPs) involving angiogenic, developmental, inflammatory, and oxidative pathways. Three analyses were performed to determine significant epidemiologic variables and SNPs associated with levels of ROP severity. Analyses controlled for multiple comparisons, ancestral eigenvalues, family relatedness, and significant epidemiologic variables. Single nucleotide polymorphisms significantly associated with ROP severity from the discovery cohort were analyzed in the replication cohort and in meta-analysis. Eight hundred seventeen infants in the discovery cohort and 543 in the replication cohort were analyzed. Severe ROP occurred in 126 infants in the discovery and in 14 in the replication cohort. In both cohorts, ventilation days and seizure occurrence were associated with severe ROP. After controlling for significant factors and multiple comparisons, two intronic SNPs in the gene BDNF (rs7934165 and rs2049046, P < 3.1 × 10(-5)) were associated with severe ROP in the discovery cohort and were not associated with severe ROP in the replication cohort. However, when the cohorts were analyzed together in an exploratory meta-analysis, rs7934165
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Neonatal Glycemia and Neurodevelopmental Outcomes at 2 Years
McKinlay, Christopher J.D.; Alsweiler, Jane M.; Ansell, Judith M.; Anstice, Nicola S.; Chase, J. Geoffrey; Gamble, Gregory D.; Harris, Deborah L.; Jacobs, Robert J.; Jiang, Yannan; Paudel, Nabin; Signal, Matthew; Thompson, Benjamin; Wouldes, Trecia A.; Yu, Tzu-Ying; Harding, Jane E.
2015-01-01
Background Neonatal hypoglycemia is common and can cause neurologic impairment, but evidence supporting thresholds for intervention is limited. Methods We performed a prospective cohort study involving 528 neonates with a gestational age of at least 35 weeks who were considered to be at risk for hypoglycemia; all were treated to maintain a blood glucose concentration of at least 47 mg per deciliter (2.6 mmol per liter). We intermittently measured blood glucose for up to 7 days. We continuously monitored interstitial glucose concentrations, which were masked to clinical staff. Assessment at 2 years included Bayley Scales of Infant Development III and tests of executive and visual function. Results Of 614 children, 528 were eligible, and 404 (77% of eligible children) were assessed; 216 children (53%) had neonatal hypoglycemia (blood glucose concentration, <47 mg per deciliter). Hypoglycemia, when treated to maintain a blood glucose concentration of at least 47 mg per deciliter, was not associated with an increased risk of the primary outcomes of neurosensory impairment (risk ratio, 0.95; 95% confidence interval [CI], 0.75 to 1.20; P = 0.67) and processing difficulty, defined as an executive-function score or motion coherence threshold that was more than 1.5 SD from the mean (risk ratio, 0.92; 95% CI, 0.56 to 1.51; P = 0.74). Risks were not increased among children with unrecognized hypoglycemia (a low interstitial glucose concentration only). The lowest blood glucose concentration, number of hypoglycemic episodes and events, and negative interstitial increment (area above the interstitial glucose concentration curve and below 47 mg per deciliter) also did not predict the outcome. Conclusions In this cohort, neonatal hypoglycemia was not associated with an adverse neurologic outcome when treatment was provided to maintain a blood glucose concentration of at least 47 mg per deciliter. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human
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Kendrick, Douglas E.; Wilson-Costello, Deanne E.; Das, Abhik; Bell, Edward F.; Vohr, Betty R.; Higgins, Rosemary D.
2011-01-01
OBJECTIVE: We compared neurodevelopmental outcomes at 18 to 22 months' corrected age of infants born with extremely low birth weight at an estimated gestational age of <25 weeks during 2 periods: 1999–2001 (epoch 1) and 2002–2004 (epoch 2). PATIENTS AND METHODS: We conducted a multicenter, retrospective analysis of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Perinatal and neonatal variables and outcomes were compared between epochs. Neurodevelopmental outcomes at 18 to 22 months' corrected age were evaluated with neurologic exams and Bayley Scales of Infant Development II. Logistic regression analyses determined the independent risk of epoch for adverse outcomes. RESULTS: Infant survival was similar between epochs (epoch 1, 35.4%, vs epoch 2, 32.3%; P = .09). A total of 411 of 452 surviving infants in epoch 1 and 405 of 438 surviving infants in epoch 2 were evaluated at 18 to 22 months' corrected age. Cesarean delivery (P = .03), surgery for patent ductus arteriosus (P = .004), and late sepsis (P = .01) were more common in epoch 2, but postnatal steroid use was dramatically reduced (63.5% vs 32.8%; P < .0001). Adverse outcomes at 18 to 22 months' corrected age were common in both epochs. Moderate-to-severe cerebral palsy was diagnosed in 11.1% of surviving infants in epoch 1 and 14.9% in epoch 2 (adjusted odds ratio [OR]: 1.52 [95% confidence interval (CI): 0.86–2.71]; P = .15), the Mental Developmental Index was <70 in 44.9% in epoch 1 and 51% in epoch 2 (OR: 1.30 [95% CI: 0.91–1.87]; P = .15), and neurodevelopmental impairment was diagnosed in 50.1% of surviving infants in epoch 1 and 58.7% in epoch 2 (OR: 1.4 [95% CI: 0.98–2.04]; P = .07). CONCLUSIONS: Early-childhood outcomes for infants born at <25 weeks' estimated gestational age were unchanged between the 2 periods. PMID:21187312
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Paganella, MP; Cohen, RA; Harris, DR; Kuchenbecker, RS; Sperhacke, RD; Kato, SK; Silva, CLO; Sturzbecher, FT; Oliveira, RHS; Pavía Ruz, N; Hazra, R
2016-01-01
Objective(s) To estimate the incidence of lipid and glucose abnormalities and assess their association with exposure to antiretroviral (ARV) regimens among perinatally HIV-infected Latin American children. Design Longitudinal cohort study. Methods Data were analyzed from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) International Site Development Initiative (NISDI) Pediatric Latin American Countries Epidemiologic Study (PLACES). The incidence of dyslipidemia (total cholesterol>200mg/dL, HDL<35mg/dL, LDL≥130mg/dL, triglycerides>110mg/dL [age<10 years] or >150mg/dL [≥10 years]) and fasting glucose abnormalities (homeostasis model assessment of insulin resistance >2.5 [Tanner Stage 1] or >4.0 [Tanner Stage>1]; impaired glucose: 110 to <126mg/dL; diabetes: ≥126 mg/dL) was estimated. Proportional hazards regression was used to evaluate the risk of abnormalities associated with ARV regimen, adjusted for covariates. Results There were 385 children eligible for analysis (mean age 6.6 years). Incident cholesterol abnormalities were reported in 18.1% of participants (95% confidence interval [CI] 14.1–22.8%), HDL and LDL cholesterol abnormalities in 19.6% (15.1–24.7%) and 15.0% (11.3–19.5%), respectively, and triglyceride abnormalities in 44.2% (37.7–50.8%). In multivariable analysis, ARV regimen was only associated with triglyceride abnormalities; participants receiving a protease inhibitor-containing (PI) regimen were 3.6 times as likely to experience a triglyceride abnormality as those receiving no ARVs (95% CI: 1.3–10.5; p=0.0167). The cumulative incidence of insulin resistance was 3.8% (1.8–7.1%); there were no incident cases of diabetes and only two of impaired fasting glucose. Conclusions Children receiving PI-containing regimens were at increased risk of developing triglyceride abnormalities. Continued monitoring of lipid levels in children receiving PI-containing regimens appears warranted. PMID:27570910
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Kapogiannis, Bill G; Chakhtoura, Nahida; Hazra, Rohan; Spong, Catherine Y
2017-05-01
The Zika virus (ZIKV) epidemic has profoundly affected the lives of children and families across the Americas. As the number of children born with ZIKV-related complications continues to grow, the long-term developmental trajectory for these children and the effect on their families remains largely unknown. In September 2016, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and partner National Institutes of Health institutes convened a workshop to develop a research agenda to improve the evaluation, monitoring, and management of neonates, infants, or children affected by ZIKV and its complications. The agenda also aims to optimally address the prospective effect of ZIKV exposure on the developing child. The full clinical spectrum of congenital ZIKV syndrome has yet to be elucidated. In addition to the well-described anatomic and neurologic manifestations, clinicians are now describing infants with exaggerated primitive reflexes, epilepsy, acquired hydrocephalus and microcephaly, neurodevelopmental delay, gastrointestinal motility problems, and respiratory complications, such as pneumonia. While we are still learning more about the myriad clinical presentations in these severely affected children, it is also paramount to address the larger proportion of ZIKV-exposed infants who are asymptomatic at birth but, we assume, may develop problems later in life. The available evidence for neurologic, neurodevelopmental, neurobehavioral, auditory, and vision assessments and management for infants with congenital ZIKV syndrome was critically evaluated. Lessons from other congenital infections provide valuable clues about the complexities of management and the optimal approaches for evaluating, treating, and caring for the children, which include engaging and involving parents and caregivers in their treatment. Rigorous research is key to improving the identification of ZIKV-infected mothers and babies. Research also is critical to
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Between-Hospital Variation in Treatment and Outcomes in Extremely Preterm Infants
Rysavy, Matthew A.; Li, Lei; Bell, Edward F.; Das, Abhik; Hintz, Susan R.; Stoll, Barbara J.; Vohr, Betty R.; Carlo, Waldemar A.; Shankaran, Seetha; Walsh, Michele C.; Tyson, Jon E.; Cotten, C. Michael; Smith, P. Brian; Murray, Jeffrey C.; Colaizy, Tarah T.; Brumbaugh, Jane E.; Higgins, Rosemary D.
2015-01-01
BACKGROUND Between-hospital variation in outcomes among extremely preterm infants is largely unexplained and may reflect differences in hospital practices regarding the initiation of active lifesaving treatment as compared with comfort care after birth. METHODS We studied infants born between April 2006 and March 2011 at 24 hospitals included in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Data were collected for 4987 infants born before 27 weeks of gestation without congenital anomalies. Active treatment was defined as any potentially lifesaving intervention administered after birth. Survival and neurodevelopmental impairment at 18 to 22 months of corrected age were assessed in 4704 children (94.3%). RESULTS Overall rates of active treatment ranged from 22.1% (interquartile range [IQR], 7.7 to 100) among infants born at 22 weeks of gestation to 99.8% (IQR, 100 to 100) among those born at 26 weeks of gestation. Overall rates of survival and survival without severe impairment ranged from 5.1% (IQR, 0 to 10.6) and 3.4% (IQR, 0 to 6.9), respectively, among children born at 22 weeks of gestation to 81.4% (IQR, 78.2 to 84.0) and 75.6% (IQR, 69.5 to 80.0), respectively, among those born at 26 weeks of gestation. Hospital rates of active treatment accounted for 78% and 75% of the between-hospital variation in survival and survival without severe impairment, respectively, among children born at 22 or 23 weeks of gestation, and accounted for 22% and 16%, respectively, among those born at 24 weeks of gestation, but the rates did not account for any of the variation in outcomes among those born at 25 or 26 weeks of gestation. CONCLUSIONS Differences in hospital practices regarding the initiation of active treatment in infants born at 22, 23, or 24 weeks of gestation explain some of the between-hospital variation in survival and survival without impairment among such patients. (Funded by the National Institutes
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Antenatal Betamethasone for Women at Risk for Late Preterm Delivery.
Gyamfi-Bannerman, Cynthia; Thom, Elizabeth A; Blackwell, Sean C; Tita, Alan T N; Reddy, Uma M; Saade, George R; Rouse, Dwight J; McKenna, David S; Clark, Erin A S; Thorp, John M; Chien, Edward K; Peaceman, Alan M; Gibbs, Ronald S; Swamy, Geeta K; Norton, Mary E; Casey, Brian M; Caritis, Steve N; Tolosa, Jorge E; Sorokin, Yoram; VanDorsten, J Peter; Jain, Lucky
2016-04-07
Infants who are born at 34 to 36 weeks of gestation (late preterm) are at greater risk for adverse respiratory and other outcomes than those born at 37 weeks of gestation or later. It is not known whether betamethasone administered to women at risk for late preterm delivery decreases the risks of neonatal morbidities. We conducted a multicenter, randomized trial involving women with a singleton pregnancy at 34 weeks 0 days to 36 weeks 5 days of gestation who were at high risk for delivery during the late preterm period (up to 36 weeks 6 days). The participants were assigned to receive two injections of betamethasone or matching placebo 24 hours apart. The primary outcome was a neonatal composite of treatment in the first 72 hours (the use of continuous positive airway pressure or high-flow nasal cannula for at least 2 hours, supplemental oxygen with a fraction of inspired oxygen of at least 0.30 for at least 4 hours, extracorporeal membrane oxygenation, or mechanical ventilation) or stillbirth or neonatal death within 72 hours after delivery. The primary outcome occurred in 165 of 1427 infants (11.6%) in the betamethasone group and 202 of 1400 (14.4%) in the placebo group (relative risk in the betamethasone group, 0.80; 95% confidence interval [CI], 0.66 to 0.97; P=0.02). Severe respiratory complications, transient tachypnea of the newborn, surfactant use, and bronchopulmonary dysplasia also occurred significantly less frequently in the betamethasone group. There were no significant between-group differences in the incidence of chorioamnionitis or neonatal sepsis. Neonatal hypoglycemia was more common in the betamethasone group than in the placebo group (24.0% vs. 15.0%; relative risk, 1.60; 95% CI, 1.37 to 1.87; P<0.001). Administration of betamethasone to women at risk for late preterm delivery significantly reduced the rate of neonatal respiratory complications. (Funded by the National Heart, Lung, and Blood Institute and the Eunice Kennedy Shriver National
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Distracted driving and risk of road crashes among novice and experienced drivers.
Klauer, Sheila G; Guo, Feng; Simons-Morton, Bruce G; Ouimet, Marie Claude; Lee, Suzanne E; Dingus, Thomas A
2014-01-02
Distracted driving attributable to the performance of secondary tasks is a major cause of motor vehicle crashes both among teenagers who are novice drivers and among adults who are experienced drivers. We conducted two studies on the relationship between the performance of secondary tasks, including cell-phone use, and the risk of crashes and near-crashes. To facilitate objective assessment, accelerometers, cameras, global positioning systems, and other sensors were installed in the vehicles of 42 newly licensed drivers (16.3 to 17.0 years of age) and 109 adults with more driving experience. During the study periods, 167 crashes and near-crashes among novice drivers and 518 crashes and near-crashes among experienced drivers were identified. The risk of a crash or near-crash among novice drivers increased significantly if they were dialing a cell phone (odds ratio, 8.32; 95% confidence interval [CI], 2.83 to 24.42), reaching for a cell phone (odds ratio, 7.05; 95% CI, 2.64 to 18.83), sending or receiving text messages (odds ratio, 3.87; 95% CI, 1.62 to 9.25), reaching for an object other than a cell phone (odds ratio, 8.00; 95% CI, 3.67 to 17.50), looking at a roadside object (odds ratio, 3.90; 95% CI, 1.72 to 8.81), or eating (odds ratio, 2.99; 95% CI, 1.30 to 6.91). Among experienced drivers, dialing a cell phone was associated with a significantly increased risk of a crash or near-crash (odds ratio, 2.49; 95% CI, 1.38 to 4.54); the risk associated with texting or accessing the Internet was not assessed in this population. The prevalence of high-risk attention to secondary tasks increased over time among novice drivers but not among experienced drivers. The risk of a crash or near-crash among novice drivers increased with the performance of many secondary tasks, including texting and dialing cell phones. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Highway Traffic Safety Administration.).
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Kennedy Center Director Opens NASA 2017 Robotic Mining Competition
2017-05-23
NASA’s Eighth Annual Robotic Mining Competition (RMC) officially kicked off at NASA’s Kennedy Space Center in Florida on Tuesday, May 23, with Kennedy Director, Bob Cabana, presiding at the annual event’s opening ceremony. Forty-five teams of college undergraduate and graduate students prepped the unique mining robots they designed and built, then conducted practice runs in their quest against the clock to collect and move the most simulated Martian soil. The actual competition is scheduled for Wednesday through Friday. Managed by, and held annually at Kennedy Space Center, RMC is a NASA Human Exploration and Operations Mission Directorate project designed to engage and retain students in science, technology, engineering and math (STEM) fields by expanding opportunities for student research and design. The project provides a competitive environment to foster innovative ideas and solutions with potential use on NASA’s deep space exploration missions, including to Mars.
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Photocopy of drawing. LAUNCH COMPLEX 39. NASA, John F. Kennedy ...
Photocopy of drawing. LAUNCH COMPLEX 39. NASA, John F. Kennedy Space Center, Florida. File Number 203-100, Urbahn-Roberts-Seelye-Moran, October, 1963. LCC FLOOR 3, LEVEL 38-0, AREA P. Sheet 29-39 - Cape Canaveral Air Force Station, Launch Complex 39, Launch Control Center, LCC Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL
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Photocopy of drawing. LAUNCH COMPLEX 39. NASA John F. Kennedy ...
Photocopy of drawing. LAUNCH COMPLEX 39. NASA John F. Kennedy Space Center, Florida. File Number 203-100, Urbahn-Roberts-Seelye-Moran, October 1963. VERTICAL ASSEMBLY BUILDING, LOW BAY, SECTIONS J-J, K-K, & L-L. Sheet 33-32 - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL
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Kennedy Center Salute To Apollo
2009-07-17
National Symphony Orchestra Conductor Emil de Cou, left, meets with Gene Kranz, retired NASA Flight Director and manager, back stage after the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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Kennedy Center Salute To Apollo
2009-07-17
Gene Kranz, retired NASA Flight Director and manager, thanks the audience after having guest conducted of the National Symphony Orchestra during the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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Kennedy Center Salute To Apollo
2009-07-17
Gene Kranz, retired NASA Flight Director and manager, conducts the National Symphony Orchestra, while the U.S. Army Chorus and Alumni sing during the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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Obama Kennedy Space Center Visit
2010-04-14
NASA Administrator Charles Bolden, right, gives introductory remarks as US Senator Bill Nelson (D-FL) listens on during an event where President Barack Obama outlined a bold new course the administration is charting to maintain U.S. leadership in human space flight at the NASA Kennedy Space Center in Cape Canaveral, Fla. on Thursday, April 15, 2010. Photo Credit: (NASA/Bill Ingalls)
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John F. Kennedy and Vietnam: The Historical Record Versus the Revisionists.
ERIC Educational Resources Information Center
Turner, Thomas R.
1995-01-01
Criticizes the current historical interpretation (promoted by Arthur Schlesinger, Jr. and Oliver Stone) that President John F. Kennedy intended to withdraw from Vietnam if elected to a second term. Maintains that the preponderance of historical evidence suggests that Kennedy intended to exit Vietnam only after a military victory. (MJP)
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
NASA Kennedy Space Center Deputy Director Janet Petro addresses agency leaders, U.S. and Florida government officials and employees inside the Vehicle Assembly Building during a visit by Vice President Mike Pence. Pence thanked employees for advancing American leadership in space. Behind the podium are, from the left, a flown SpaceX Dragon capsule, the Orion spacecraft flown on Exploration Flight test-1 in 2014, and a mockup of Boeing's CST-100 Starliner. During his visit to Kennedy, the Vice President also toured several facilities highlighting the public-private partnerships, as both NASA and commercial companies prepare to launch American astronauts from the multi-user spaceport.
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
Vice President Mike Pence speaks before an audience of NASA leaders, U.S. and Florida government officials, and employees inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. Pence thanked employees for advancing American leadership in space. Behind the podium are, from the left, a flown SpaceX Dragon capsule, the Orion spacecraft flown on Exploration Flight test-1 in 2014, and a mockup of Boeing's CST-100 Starliner. During his visit to Kennedy, the Vice President also toured several facilities highlighting the public-private partnerships, as both NASA and commercial companies prepare to launch American astronauts from the multi-user spaceport.
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Vice President Mike Pence Visits Kennedy Space Center
2017-07-06
Acting NASA Administrator Robert Lightfoot addresses agency leaders, U.S. and Florida government officials, and employees inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida during a visit by Vice President Mike Pence. Pence thanked employees for advancing American leadership in space. Behind the podium are, from the left, a flown SpaceX Dragon capsule, the Orion spacecraft flown on Exploration Flight test-1 in 2014, and a mockup of Boeing's CST-100 Starliner. During his visit to Kennedy, the Vice President also toured several facilities highlighting the public-private partnerships, as both NASA and commercial companies prepare to launch American astronauts from the multi-user spaceport.
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Zero Robotics at Kennedy Space Center Visitor Complex
2017-08-11
A trio of programmable off-the-shelf Sphero robots are shown at the Center for Space Education at NASA's Kennedy Space Center in Florida. The Spheros were available for students to practice their programming skills during "loss of signal" times when the connection to the International Space Station was temporarily unavailable. Teams from across the state of Florida were gathered at Kennedy for the finals of the Zero Robotics Middle School Summer Program national championship. The five-week program allows rising sixth- through ninth-graders to write programs for small satellites called SPHERES (Synchronized, Position, Hold, Engage, Reorient, Experimental Satellites). Finalists saw their code tested aboard the orbiting laboratory.
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Obama Kennedy Space Center Visit
2010-04-14
President Barack Obama takes the stage after being introduced by NASA Administrator Charles Bolden, right, and US Senator Bill Nelson (D-FL) during an event where Obama outlined a bold new course the administration is charting to maintain U.S. leadership in human space flight at the NASA Kennedy Space Center in Cape Canaveral, Fla. on Thursday, April 15, 2010. Photo Credit: (NASA/Bill Ingalls)
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Kennedy Center Salute To Apollo
2009-07-17
Conductor Emil de Cou and The U.S. Army Chorus and Alumni sing while Gene Kranz, retired NASA Flight Director and manager, acts as guest conductor of the National Symphony Orchestra, during the "Salute to Apollo" ceremony at the Kennedy Center for the Performing Arts, Saturday, July 18, 2009 in Washington. The event was part of NASA's week long celebration of the Apollo 40th Anniversary. Photo Credit: (NASA/Bill Ingalls)
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Obama Kennedy Space Center Visit
2010-04-14
President Barack Obama, center, back to camera, shakes hands with NASA Administrator Charles Bolden, right, as U.S. Sen. Bill Nelson, D-Fla., looks on prior to Obama's speech outlining the bold new course the administration is charting to maintain U.S. leadership in human space flight at the NASA Kennedy Space Center in Cape Canaveral, Fla. on Thursday, April 15, 2010. Photo Credit: (NASA/Paul E. Alers)
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Vice President Mike Pence Visits Kennedy Space Center
2018-02-20
Vice President Mike Pence, second from right, and his wife, Karen Pence, tour the Blue Origin Manufacturing Facility near NASA's Kennedy Space Center in Florida, on Feb. 20, 2018. Vice President Pence viewed the flown New Shepard Booster and Crew Capsule. The Crew Capsule, in view, flew seven times, including a pad abort test and an escape test at maximum dynamic pressure. During his visit, Pence will chair a meeting of the National Space Council on Feb. 21, 2018 in the high bay of NASA Kennedy Space Center's Space Station Processing Facility. The council's role is to advise the president regarding national space policy and strategy, and review the nation's long-range goals for space activities.
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Vice President Mike Pence Visits Kennedy Space Center
2018-02-20
Vice President Mike Pence, at left, tours the Blue Origin Manufacturing Facility near NASA's Kennedy Space Center in Florida, Feb. 20, 2018, with the company's CEO Robert Smith. Vice President Pence viewed the flown New Shepard Booster and Crew Capsule. The booster was the first launch vehicle with a successful vertical takeoff and vertical landing to demonstrate reusability. During his visit, Pence will chair a meeting of the National Space Council on Feb. 21, 2018 in the high bay of NASA Kennedy Space Center's Space Station Processing Facility. The council's role is to advise the president regarding national space policy and strategy, and review the nation's long-range goals for space activities.
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The Kennedy Report: Commission Evaluates High School Journalism
ERIC Educational Resources Information Center
Heintz, Ann
1974-01-01
Presents excerpts from the report of the Kennedy Commission of Inquiry into High School Journalism, concentrating on censorship, minority participation, journalism education, established media, and censorship issues.
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50th anniversary of the inauguration of John F. Kennedy
2011-01-20
Caroline Kennedy, center, is recognized by U.S. Vice President Joe Biden, left, Senate Majority Leader Harry Reid (D-NV), second from left, former U.S. Labor Secretary Elaine Chao, and U.S. Senator John Kerry (D-MA), right, at an event recognizing the 50th anniversary of the inauguration of John F. Kennedy as President of the United States, Thursday, Jan. 20, 2011 in the rotunda at the U.S. Capitol. Photo Credit: (NASA/Bill Ingalls)
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2003-08-26
KENNEDY SPACE CENTER, FLA. - KSC Director James W. Kennedy receives Consul General of Japan Ko Kodaira and his family in his office in Headquarters Building during their visit to Kennedy Space Center (KSC). From left are Kodaira's daughter Reiko, his wife Marie, Kodaira, and Kennedy. Kodaira is touring the facilities at KSC at the invitation of the local office of the National Space Development Agency of Japan (NASDA) to acquaint him with KSC's unique processing capabilities.
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2003-08-26
KENNEDY SPACE CENTER, FLA. - KSC Director James W. Kennedy receives Consul General of Japan Ko Kodaira and his family in his office in Headquarters Building during their visit to Kennedy Space Center (KSC). From left are Kennedy, Kodaira, his wife Marie (partially hidden), and his daughter Reiko. Kodaira is touring the facilities at KSC at the invitation of the local office of the National Space Development Agency of Japan (NASDA) to acquaint him with KSC's unique processing capabilities.
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KENNEDY, PRESIDENT JOHN F. - MSC VISIT
1962-09-11
S62-03991 (11 September 1962) --- Just before the arrival of President John F. Kennedy at the J. P. Cornelius grade school, on Westover, turned out for a look at the Chief Executive in person. Wearing sun hats they made themselves, 700 children lined the roadway opposite the side entrance to the Rich Building.
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Obama Kennedy Space Center Visit
2010-04-14
President Barack Obama tours the commercial rocket processing facility of Space Exploration Technologies, known as SpaceX, along with Elon Musk, SpaceX CEO at Cape Canaveral Air Force Station, Cape Canaveral, Fla. on Thursday, April 15, 2010. Obama also visited the NASA Kennedy Space Center to deliver remarks on the bold new course the administration is charting to maintain U.S. leadership in human space flight. Photo Credit: (NASA/Bill Ingalls)
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Kennedy Space Center exercise program
NASA Technical Reports Server (NTRS)
Hoffman, Cristy
1993-01-01
The Kennedy Space Center (KSC) Fitness Program began in Feb. 1993. The program is managed by the Biomedical Operations and Research Office and operated by the Bionetics Corporation. The facilities and programs are offered to civil servants, all contractors, temporary duty assignment (TDY) participants, and retirees. All users must first have a medical clearance. A computer-generated check-in system is used to monitor participant usage. Various aspects of the program are discussed.
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Composite Structures Repair Development at Kennedy Space Center
NASA Technical Reports Server (NTRS)
Cox, Sarah B.
2015-01-01
This presentation discusses the development and results of composite patch repair perfromed at Kennedy Space Center. This includes impact damage, patch repair methods, nondestructive evaluation, and edgewise compression testing.
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Kennedy Space Center Medical Operations and Medical Kit
NASA Technical Reports Server (NTRS)
Scarpa, Philip
2011-01-01
This slide presentation reviews the emergency medical operations at Kennedy Space center, the KSC launch and landing contingency modes, the triage site, the medical kit, and the medications available.
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Winners of the First 1960 Televised Presidential Debate between Kennedy and Nixon.
ERIC Educational Resources Information Center
Kraus, Sidney
1996-01-01
Reviews the events, studies, and comments (from 1960 to the present) regarding the controversial question of who won the first 1960 televised debate between John F. Kennedy and Richard M. Nixon. Supports the view that, for television viewers, Kennedy was the winner, whereas radio listeners gave Nixon the edge. (SR)