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Sample records for european clearinghouse contributing

  1. Catalog of ERIC Clearinghouse Publications.

    ERIC Educational Resources Information Center

    Bourbon, Terri, Ed.

    The "Catalog of ERIC Clearinghouse Publications" lists approximately 500 titles of publications prepared by the ERIC Clearinghouses and currently available in original copies from them. It is the equivalent of a "Books-in-Print" for the ERIC Clearinghouses. The titles listed range across the past several years. Titles are…

  2. ENERGY INFORMATION CLEARINGHOUSE

    SciTech Connect

    Ron Johnson

    2003-10-01

    Alaska has spent billions of dollars on various energy-related activities over the past several decades, with projects ranging from smaller utilities used to produce heat and power in rural Alaska to huge endeavors relating to exported resources. To help provide information for end users, utilities, decision makers, and the general public, the Institute of Northern Engineering at UAF established an Energy Information Clearinghouse accessible through the worldwide web in 2002. This clearinghouse contains information on energy resources, end use technologies, policies, related environmental issues, emerging technologies, efficiency, storage, demand side management, and developments in Alaska.

  3. Great Lakes Initiative (GLI) Clearinghouse

    EPA Pesticide Factsheets

    The Great Lakes Initiative Toxicity Clearinghouse is a central location for information on criteria, toxicity data, exposure parameters and other supporting documents used in developing water quality standards in the Great Lakes watershed.

  4. Egpm - The Proposed European Contribution To The Global Precipitation Mission

    NASA Astrophysics Data System (ADS)

    Mugnai, A.; Testud, J.; Egpm Science Team

    The U.S. and Japan space agencies (NASA and NASDA, respectively) are presently formulating a new joint mission, called the Global Precipitation Mission (GPM), aimed at measuring precipitation on a global basis with sufficient quality, Earth cover- age, and sampling to improve prediction of the Earth's climate, weather, and specific components of the global water cycle. GPM will consist of two components: a large "core" platform inclined at about 65 and equipped with both passive and active mi- crowave instruments, and a constellation of up to eight "drone" satellites (mostly in sun-synchronous orbits), carrying passive MW radiometers to provide global rain- fall coverage at 3-hour intervals (depending on latitude). The mission, which will be launched in the 2007-2008 time frame, is in fact a multinational satellite project. NASA and NASDA will provide the core satellite and two drones, but are expecting international cooperation for the other drones. Noteworthy, GPM would provide a sig- nificant contribution to the monitoring and the understanding of hazardous and flash- flood producing storms along the Mediterranean coasts, and would improve the fore- cast skill of global and regional Numerical Weather Prediction (NWP) models through data assimilation of precipitation measurements. Thus, a large part of the European scientific and operational community is strongly interested in GPM. Especially, the operational community related to NWP, nowcasting and hydrological hazards would take advantage of Europe being part of the constellation, because this would guar- antee direct access to real-time data. In this paper, we describe the characteristics of the European GPM (EGPM) constellation member, that has been recently proposed to the European Space Agency (ESA) in order to encourage it to directly engage in the international development of GPM.

  5. Mercury Information Clearinghouse

    SciTech Connect

    Chad A. Wocken; Michael J. Holmes; Dennis L. Laudal; Debra F. Pflughoeft-Hassett; Greg F. Weber; Nicholas V. C. Ralston; Stanley J. Miller; Grant E. Dunham; Edwin S. Olson; Laura J. Raymond; John H. Pavlish; Everett A. Sondreal; Steven A. Benson

    2006-03-31

    The Canadian Electricity Association (CEA) identified a need and contracted the Energy & Environmental Research Center (EERC) to create and maintain an information clearinghouse on global research and development activities related to mercury emissions from coal-fired electric utilities. With the support of CEA, the Center for Air Toxic Metals{reg_sign} (CATM{reg_sign}) Affiliates, and the U.S. Department of Energy (DOE), the EERC developed comprehensive quarterly information updates that provide a detailed assessment of developments in the various areas of mercury monitoring, control, policy, and research. A total of eight topical reports were completed and are summarized and updated in this final CEA quarterly report. The original quarterly reports can be viewed at the CEA Web site (www.ceamercuryprogram.ca). In addition to a comprehensive update of previous mercury-related topics, a review of results from the CEA Mercury Program is provided. Members of Canada's coal-fired electricity generation sector (ATCO Power, EPCOR, Manitoba Hydro, New Brunswick Power, Nova Scotia Power Inc., Ontario Power Generation, SaskPower, and TransAlta) and CEA, have compiled an extensive database of information from stack-, coal-, and ash-sampling activities. Data from this effort are also available at the CEA Web site and have provided critical information for establishing and reviewing a mercury standard for Canada that is protective of environment and public health and is cost-effective. Specific goals outlined for the CEA mercury program included the following: (1) Improve emission inventories and develop management options through an intensive 2-year coal-, ash-, and stack-sampling program; (2) Promote effective stack testing through the development of guidance material and the support of on-site training on the Ontario Hydro method for employees, government representatives, and contractors on an as-needed basis; (3) Strengthen laboratory analytical capabilities through

  6. Distance Education Clearinghouse Web Site.

    ERIC Educational Resources Information Center

    Adams, Kate; Martin, Sara

    A World Wide Web site, developed by University of Nebraska-Lincoln Information Services staff and funded by a NEB*SAT (Nebraska's multiple channel satellite and optical fiber educational telecommunications network) grant, provides a clearinghouse of distance education, Internet, and Web page development information that is useful to librarians and…

  7. LEMUR: Large European module for solar Ultraviolet Research. European contribution to JAXA's Solar-C mission

    NASA Astrophysics Data System (ADS)

    Teriaca, Luca; Andretta, Vincenzo; Auchère, Frédéric; Brown, Charles M.; Buchlin, Eric; Cauzzi, Gianna; Culhane, J. Len; Curdt, Werner; Davila, Joseph M.; Del Zanna, Giulio; Doschek, George A.; Fineschi, Silvano; Fludra, Andrzej; Gallagher, Peter T.; Green, Lucie; Harra, Louise K.; Imada, Shinsuke; Innes, Davina; Kliem, Bernhard; Korendyke, Clarence; Mariska, John T.; Martínez-Pillet, Valentin; Parenti, Susanna; Patsourakos, Spiros; Peter, Hardi; Poletto, Luca; Rutten, Robert J.; Schühle, Udo; Siemer, Martin; Shimizu, Toshifumi; Socas-Navarro, Hector; Solanki, Sami K.; Spadaro, Daniele; Trujillo-Bueno, Javier; Tsuneta, Saku; Dominguez, Santiago Vargas; Vial, Jean-Claude; Walsh, Robert; Warren, Harry P.; Wiegelmann, Thomas; Winter, Berend; Young, Peter

    2012-10-01

    The solar outer atmosphere is an extremely dynamic environment characterized by the continuous interplay between the plasma and the magnetic field that generates and permeates it. Such interactions play a fundamental role in hugely diverse astrophysical systems, but occur at scales that cannot be studied outside the solar system. Understanding this complex system requires concerted, simultaneous solar observations from the visible to the vacuum ultraviolet (VUV) and soft X-rays, at high spatial resolution (between 0.1'' and 0.3''), at high temporal resolution (on the order of 10 s, i.e., the time scale of chromospheric dynamics), with a wide temperature coverage (0.01 MK to 20 MK, from the chromosphere to the flaring corona), and the capability of measuring magnetic fields through spectropolarimetry at visible and near-infrared wavelengths. Simultaneous spectroscopic measurements sampling the entire temperature range are particularly important. These requirements are fulfilled by the Japanese Solar-C mission (Plan B), composed of a spacecraft in a geosynchronous orbit with a payload providing a significant improvement of imaging and spectropolarimetric capabilities in the UV, visible, and near-infrared with respect to what is available today and foreseen in the near future. The Large European Module for solar Ultraviolet Research (LEMUR), described in this paper, is a large VUV telescope feeding a scientific payload of high-resolution imaging spectrographs and cameras. LEMUR consists of two major components: a VUV solar telescope with a 30 cm diameter mirror and a focal length of 3.6 m, and a focal-plane package composed of VUV spectrometers covering six carefully chosen wavelength ranges between 170 Å and 1270 Å. The LEMUR slit covers 280'' on the Sun with 0.14'' per pixel sampling. In addition, LEMUR is capable of measuring mass flows velocities (line shifts) down to 2 km s - 1 or better. LEMUR has been proposed to ESA as the European contribution to the Solar

  8. Understanding the Position of Lesser Used Languages in European Educational Systems: The Contribution of Comparative Education.

    ERIC Educational Resources Information Center

    Renkema, Wim Jan T.

    This study looks at how the methodology of comparative education research has contributed, or not contributed, to understanding the role of minority languages in European education systems. An introductory chapter of the report is devoted to explanation of the work of Mercator-Education, a European center concerned with languages not commonly…

  9. National clearinghouse for Loma Prieta earthquake information catalog, November 1991

    SciTech Connect

    Not Available

    1991-01-01

    This catalog lists 440 new citations including recently completed work, abstracts of National Science Foundation research projects in progress, and contributions to the clearinghouse received after April, 1991. Section titles are: General topics and conference proceedings; Selected topics in seismology; Engineering seismology; Strong-motion seismometry; Dynamics of soils, rocks, and foundations; Dynamics of structures; Earthquake-resistant design and construction; Earthquake damage; and Earthquakes as natural disasters. Included are indexes by author, title, subject, and format.

  10. Ancestry of modern Europeans: contributions of ancient DNA.

    PubMed

    Lacan, Marie; Keyser, Christine; Crubézy, Eric; Ludes, Bertrand

    2013-07-01

    Understanding the peopling history of Europe is crucial to comprehend the origins of modern populations. Of course, the analysis of current genetic data offers several explanations about human migration patterns which occurred on this continent, but it fails to explain precisely the impact of each demographic event. In this context, direct access to the DNA of ancient specimens allows the overcoming of recent demographic phenomena, which probably highly modified the constitution of the current European gene pool. In recent years, several DNA studies have been successfully conducted from ancient human remains thanks to the improvement of molecular techniques. They have brought new fundamental information on the peopling of Europe and allowed us to refine our understanding of European prehistory. In this review, we will detail all the ancient DNA studies performed to date on ancient European DNA from the Middle Paleolithic to the beginning of the protohistoric period.

  11. 2 CFR 200.36 - Federal Audit Clearinghouse (FAC).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Federal Audit Clearinghouse (FAC). 200.36... Clearinghouse (FAC). FAC means the clearinghouse designated by OMB as the repository of record where non-Federal... part. The mailing address of the FAC is Federal Audit Clearinghouse, Bureau of the Census, 1201 E. 10th...

  12. Use of a technical clearinghouse during emergencies

    USGS Publications Warehouse

    Mortensen, Carl E.; Eisner, Richard K.; Davis, James F.; Reichle, Michael S.; ,

    1996-01-01

    A clearinghouse for managing and disseminating scientific and engineering information during emergency operations has been successfully used after several recent earthquakes in California. The clearinghouse has been used to coordinate the activities of geologists and engineers conducting reconnaissance for post-earthquake investigations. Observations that may be important for officials managing response and recovery operations are summarized and conveyed to them.

  13. 33 CFR 273.18 - Clearinghouse coordination.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Clearinghouse coordination. 273.18 Section 273.18 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE AQUATIC PLANT CONTROL § 273.18 Clearinghouse coordination. Procedures prescribed under...

  14. European meteorological data: contribution to research, development, and policy support

    NASA Astrophysics Data System (ADS)

    Biavetti, Irene; Karetsos, Sotiris; Ceglar, Andrej; Toreti, Andrea; Panagos, Panos

    2014-08-01

    The Joint Research Centre of the European Commission has developed Interpolated Meteorological Datasets available on a regular 25x25km grid both to the scientific community and the general public. Among others, the Interpolated Meteorological Datasets include daily maximum/minimum temperature, cumulated daily precipitation, evapotranspiration and wind speed. These datasets can be accessed through a web interface after a simple registration procedure. The Interpolated Meteorological Datasets also serve the Crop Growth Monitoring System (CGMS) at European level. The temporal coverage of the datasets is more than 30 years and the spatial coverage includes EU Member States, neighboring European countries, and the Mediterranean countries. The meteorological data are highly relevant for the development, implementation and assessment of a number of European Union (EU) policy areas: agriculture, soil protection, environment, agriculture, food security, energy, climate change. An online user survey has been carried out in order to assess the impact of the Interpolated Meteorological Datasets on research developments. More than 70% of the users have used the meteorological datasets for research purposes and more than 50% of the users have used those sources as main input for their models. The usefulness of the data scored more than 70% and it is interesting to note that around 25% of the users have published their scientific outputs based on the Interpolated Meteorological Datasets. Finally, the user feedback focuses mostly on improving the data distribution process as well as the visibility of the web platform.

  15. Establishing a State Alcohol Information Clearinghouse.

    ERIC Educational Resources Information Center

    Newman, Ian M.; And Others

    1982-01-01

    Describes the process the Nebraska Alcohol Information Clearinghouse (NAIC) used to establish its clientele and market area. Identifies valuable experiences for others planning to establish a similar information dissemination agency. (Author/RC)

  16. FFCAct Clearinghouse, Directory of abstracts. Revision 1

    SciTech Connect

    Harwood, T.

    1994-05-01

    The Federal Facility Compliance Act (FFCAct) Clearinghouse is a card catalog of information about the FFCAct and its requirements for developing Site Treatment Plans (STP). The information available in the clearinghouse includes abstracts describing computer applications, technical reports, and a list of technical experts. Information can be accessed for use in responding to FFCAct requirements, and the clearinghouse provides search capabilities on particular topics and issues related to STP development. Appendix A includes: contacts from each site, for which contact has been made, who are developing STPs; the FFCAct Clearinghouse Fact Sheet and; additional hard copy forms to be used to populate the database. This report contains 50 abstracts related to the Radioactive Waste Technical Support Program.

  17. [Gene geography of Chile: regional distribution of American, European and African genetic contributions].

    PubMed

    Fuentes, Macarena; Pulgar, Iván; Gallo, Carla; Bortolini, María-Cátira; Canizales-Quinteros, Samuel; Bedoya, Gabriel; González-José, Rolando; Ruiz-Linares, Andrés; Rothhammer, Francisco

    2014-03-01

    The geographical distribution of genes plays a key role in genetic epidemiology. The Chilean population has three major stem groups (Native American, European and African). To estimate the regional rate of American, European and African admixture of the Chilean population. Forty single nucleotide polymorphisms (SNP´s) which exhibit substantially different frequencies between Amerindian populations (ancestry-informative markers or AIM´s), were genotyped in a sample of 923 Chilean participants to estimate individual genetic ancestry. The American, European and African individual average admixture estimates for the 15 Chilean Regions were relatively homogeneous and not statistically different. However, higher American components were found in northern and southern Chile and higher European components were found in central Chile. A negative correlation between African admixture and latitude was observed. On the average, American and European genetic contributions were similar and significantly higher than the African contribution. Weighted mean American, European and African genetic contributions of 44.34% ± 3 9%, 51.85% ± 5.44% and 3.81% ± 0.45%, were estimated. Fifty two percent of subjects harbor African genes. Individuals with Aymara and Mapuche surnames have an American admixture of 58.64% and 68.33%, respectively. Half of the Chilean population harbors African genes. Participants with Aymara and Mapuche surnames had a higher American genetic contribution than the general Chilean population. These results confirm the usefulness of surnames as a first approximation to determine genetic ancestry.

  18. GEOSS Clearinghouse Quality Metadata Analysis

    NASA Astrophysics Data System (ADS)

    Masó, J.; Díaz, P.; Ninyerola, M.; Sevillano, E.; Pons, X.

    2012-04-01

    The proliferation of similar Earth observation digital data products increases the relevance of data quality information of those datasets. GEOSS is investing important efforts in promoting the acknowledgment of the data quality in Earth observation. Activities, such as the regular meeting of QA4EO and projects as GeoViQua have the aim to make the data quality available and visible in the GEOSS Common Infrastructure (GCI). The clearinghouse is one of the main components of the GCI, which catalogues all the known Earth observation resources and provide it via the GEO Portal. Actually, after several initiatives to stimulate that (such as AIP4) most of the relevant international data providers referenced their data in the GEOSS Component and Service Registry, therefore, the GEOSS clearinghouse can be considered a global catalogue of the main Earth observation products. However, there are some important catalogues still in the process of being integrated. We developed an exhaustive study of the data quality elements available on the metadata catalogue in the GEOSS clearinghouse, to elaborate a state-of-the-art report on data quality. The clearinghouse is harvested using the OGC CSW port. Metadata following the standard ISO 19115 is saved in XML-ISO 19139 files. The semi-automatic methodology, previously applied in regional SDIs studies, generates a big metadata database that can be further analyzed. The number of metadata records harvested was 97203 (October 2011). The two main metadata nodes studied are directly related with data quality information package (DQ_DataQuality) in ISO. These are the quality indicators (DQ_Element) and the lineage information (LI_Lineage). Moreover, we also considered the usage information (MD_Usage). The results reveal 19107 (19.66%) metadata records containing quality indicators; which include a total of 52187 quality indicators. The results show also a main representation of the positional accuracy, with 37.19% of the total

  19. The Multi-purpose Crew Vehicle European Service Module: a European Contribution to Human Exploration

    NASA Technical Reports Server (NTRS)

    Berthe, Philippe; Schubert, Kathleen; Grantier, Julie; Pietsch, Klaus; Angelillo, Philippe; Price, Laurence

    2013-01-01

    This paper provides an overview of the system and subsystem configuration of the MPCV European Service Module (ESM) at Preliminary Design Review (PDR) stage as well as its perspectives of utilisation within the global space exploration endeavour. The MPCV ESM is a cylindrical module with a diameter of 4500 mm and a total length – main engine excluded – of 2700 mm. It is fitted with four solar array wings with a span of 18.8 m. Its dry mass is 3.5 metric tons and it can carry 8.6 tons of propellant. The main functions of the European Service Module are to bring the structural continuity between the launcher and the crew module, to provide propulsion to the MPCV, to ensure its thermal control as well as electrical power and to store water, oxygen and nitrogen for the mission. The current agreement foresees the development and production by Europe of one flight model, with an option for a second one. This module will be assembled in Europe and delivered to NASA in 2016. It will be used for a flight of the MPCV Orion in December 2017.

  20. The Multi-purpose Crew Vehicle European Service Module: a European Contribution to Human Exploration

    NASA Technical Reports Server (NTRS)

    Schubert, Kathleen; Berthe, Philippe; Grantier, Julie; Pietsch, Klaus; Angelillo, Philippe; Price, Laurence

    2013-01-01

    This paper provides an overview of the system and subsystem configuration of the MPCV European Service Module (ESM) at Preliminary Design Review (PDR) stage as well as its perspectives of utilisation within the global space exploration endeavour. The MPCV ESM is a cylindrical module with a diameter of 4500 mm and a total length - main engine excluded - of 2700 mm. It is fitted with four solar array wings with a span of 18.8 m. Its dry mass is 3.5 metric tons and it can carry 8.6 tons of propellant. The main functions of the European Service Module are to bring the structural continuity between the launcher and the crew module, to provide propulsion to the MPCV, to ensure its thermal control as well as electrical power and to store water, oxygen and nitrogen for the mission. The current agreement foresees the development and production by Europe of one flight model, with an option for a second one. This module will be assembled in Europe and delivered to NASA in 2016. It will be used for a flight of the MPCV Orion in December 2017.

  1. The European Drought Observatory (EDO) - A European Contribution to a Global Drought Information System (GDIS)

    NASA Astrophysics Data System (ADS)

    Vogt, J.; Sepulcre, G.; De Jager, A.; Magni, D.; Valentini, L.; Russo, S.; Micale, F.; Barbosa, P.

    2013-12-01

    Europe has repeatedly been affected by droughts, resulting in considerable ecological and economic damage and climate change studies indicate a trend towards increasing climate variability most likely resulting in more frequent drought occurrences also in Europe. Against this background, the European Commission's Joint Research Centre (JRC) is developing methods and tools for assessing, monitoring and forecasting droughts in Europe and develops a European Drought Observatory (EDO) to complement and integrate national activities with a European view. At the core of EDO is a portal, including a map viewer, a metadata catalogue, a media-monitor and analysis tools. Underlying data stem from ground and satellite observations as well as from distributed hydrological models and are stored in a relational database. Through the map viewer Europe-wide up-to-date information on the occurrence and severity of droughts is presented, complemented by more detailed information from regional, national and local observatories through OGC compliant web-mapping services. The continent-wide meteorological, soil moisture-related and vegetation-related indicators are then integrated into a combined indicator showing different alert levels targeted specifically to decision makers in water and land management. Finally, time series of historical maps as well as graphs of the temporal evolution of drought indices for individual grid cells in Europe can be retrieved and analysed. On-going work is focusing on developing reliable medium and long-range probabilistic as well as seasonal drought forecasts, the analysis of climate change impacts on drought occurrence, duration and severity and the assessment of current and future drought hazard and risk. In addition, remote sensing-based water-stress indicators from geostationary satellite data (e.g., MSG SEVIRI) are developed in order to complement the available information. The further development of EDO as part of a Global Drought Information

  2. Clearinghouse.

    ERIC Educational Resources Information Center

    Joyce, Robert P., Ed.

    1992-01-01

    Summarizes court cases and opinions affecting North Carolina schools. Cases involve supervision of desegregating districts; sexual harassment charges; employee dismissal; constitutionality of a African-American-only scholarship program; contract renewals for community college employees; equal pay, sex, and racial discrimination lawsuits; air…

  3. 19 CFR 24.26 - Automated Clearinghouse credit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Automated Clearinghouse credit. 24.26 Section 24... THE TREASURY CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.26 Automated Clearinghouse credit. (a) Description. Automated Clearinghouse (ACH) credit is an optional payment method that allows a payer...

  4. 19 CFR 24.26 - Automated Clearinghouse credit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Automated Clearinghouse credit. 24.26 Section 24... THE TREASURY CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.26 Automated Clearinghouse credit. (a) Description. Automated Clearinghouse (ACH) credit is an optional payment method that allows a payer...

  5. 19 CFR 24.26 - Automated Clearinghouse credit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Automated Clearinghouse credit. 24.26 Section 24... THE TREASURY CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.26 Automated Clearinghouse credit. (a) Description. Automated Clearinghouse (ACH) credit is an optional payment method that allows a payer...

  6. 19 CFR 24.26 - Automated Clearinghouse credit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Automated Clearinghouse credit. 24.26 Section 24... THE TREASURY CUSTOMS FINANCIAL AND ACCOUNTING PROCEDURE § 24.26 Automated Clearinghouse credit. (a) Description. Automated Clearinghouse (ACH) credit is an optional payment method that allows a payer to...

  7. Global diversity and genetic contributions of chicken populations from African, Asian and European regions.

    PubMed

    Lyimo, C M; Weigend, A; Msoffe, P L; Eding, H; Simianer, H; Weigend, S

    2014-12-01

    Genetic diversity and population structure of 113 chicken populations from Africa, Asia and Europe were studied using 29 microsatellite markers. Among these, three populations of wild chickens and nine commercial purebreds were used as reference populations for comparison. Compared to commercial lines and chickens sampled from the European region, high mean numbers of alleles and a high degree of heterozygosity were found in Asian and African chickens as well as in Red Junglefowl. Population differentiation (FST ) was higher among European breeds and commercial lines than among African, Asian and Red Junglefowl populations. Neighbour-Net genetic clustering and structure analysis revealed two main groups of Asian and north-west European breeds, whereas African populations overlap with other breeds from Eastern Europe and the Mediterranean region. Broilers and brown egg layers were situated between the Asian and north-west European clusters. structure analysis confirmed a lower degree of population stratification in African and Asian chickens than in European breeds. High genetic differentiation and low genetic contributions to global diversity have been observed for single European breeds. Populations with low genetic variability have also shown a low genetic contribution to a core set of diversity in attaining maximum genetic variation present from the total populations. This may indicate that conservation measures in Europe should pay special attention to preserving as many single chicken breeds as possible to maintain maximum genetic diversity given that higher genetic variations come from differentiation between breeds. © 2014 Stichting International Foundation for Animal Genetics.

  8. Smart Grid Information Clearinghouse (SGIC)

    SciTech Connect

    Rahman, Saifur

    2014-08-31

    Since the Energy Independence and Security Act of 2007 was enacted, there has been a large number of websites that discusses smart grid and relevant information, including those from government, academia, industry, private sector and regulatory. These websites collect information independently. Therefore, smart grid information was quite scattered and dispersed. The objective of this work was to develop, populate, manage and maintain the public Smart Grid Information Clearinghouse (SGIC) web portal. The information in the SGIC website is comprehensive that includes smart grid information, research & development, demonstration projects, technical standards, costs & benefit analyses, business cases, legislation, policy & regulation, and other information on lesson learned and best practices. The content in the SGIC website is logically grouped to allow easily browse, search and sort. In addition to providing the browse and search feature, the SGIC web portal also allow users to share their smart grid information with others though our online content submission platform. The Clearinghouse web portal, therefore, serves as the first stop shop for smart grid information that collects smart grid information in a non-bias, non-promotional manner and can provide a missing link from information sources to end users and better serve users’ needs. The web portal is available at www.sgiclearinghouse.org. This report summarizes the work performed during the course of the project (September 2009 – August 2014). Section 2.0 lists SGIC Advisory Committee and User Group members. Section 3.0 discusses SGIC information architecture and web-based database application functionalities. Section 4.0 summarizes SGIC features and functionalities, including its search, browse and sort capabilities, web portal social networking, online content submission platform and security measures implemented. Section 5.0 discusses SGIC web portal contents, including smart grid 101, smart grid projects

  9. OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and Europeans.

    PubMed

    Quillen, Ellen E; Bauchet, Marc; Bigham, Abigail W; Delgado-Burbano, Miguel E; Faust, Franz X; Klimentidis, Yann C; Mao, Xianyun; Stoneking, Mark; Shriver, Mark D

    2012-07-01

    Contemporary variation in skin pigmentation is the result of hundreds of thousands years of human evolution in new and changing environments. Previous studies have identified several genes involved in skin pigmentation differences among African, Asian, and European populations. However, none have examined skin pigmentation variation among Indigenous American populations, creating a critical gap in our understanding of skin pigmentation variation. This study investigates signatures of selection at 76 pigmentation candidate genes that may contribute to skin pigmentation differences between Indigenous Americans and Europeans. Analysis was performed on two samples of Indigenous Americans genotyped on genome-wide SNP arrays. Using four tests for natural selection--locus-specific branch length (LSBL), ratio of heterozygosities (lnRH), Tajima's D difference, and extended haplotype homozygosity (EHH)--we identified 14 selection-nominated candidate genes (SNCGs). SNPs in each of the SNCGs were tested for association with skin pigmentation in 515 admixed Indigenous American and European individuals from regions of the Americas with high ground-level ultraviolet radiation. In addition to SLC24A5 and SLC45A2, genes previously associated with European/non-European differences in skin pigmentation, OPRM1 and EGFR were associated with variation in skin pigmentation in New World populations for the first time.

  10. Dropout Prevention. What Works Clearinghouse Topic Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2007

    2007-01-01

    Dropout prevention programs are school- and community-based initiatives that aim to keep students in school and encourage them to complete their high school education. To be included in the What Works Clearinghouse (WWC) review, programs have to operate within the United States and include dropout prevention as one of their primary objectives.…

  11. Oregon Intellectual Freedom Clearinghouse: Third Annual Report.

    ERIC Educational Resources Information Center

    Oregon State Library, Salem. Intellectual Freedom Clearinghouse.

    The Oregon Intellectual Freedom Clearinghouse received reports of formal challenges to 25 books and 1 recording during the time period between July 1, 1989, and June 30, 1990. It is noted that 17 of the challenged items were held by public libraries and 9 by school library media centers, with 21 items designated as children's and young adult…

  12. Synthesizing Evidence: Synthesis Methods for Evidence Clearinghouses

    ERIC Educational Resources Information Center

    Valentine, Jeff; Lau, Timothy

    2015-01-01

    Following the theme of the first two presentations, this presentation will focus on the choices available for research synthesis when summarizing research evidence. The presenters will describe the current research synthesis practice of the What Works Clearinghouse (WWC) as well as several alternative models, including inverse-variance weighted…

  13. European Perceptions of Plan Colombia: A Virtual Contribution to a Virtual War and Peace Plan?

    DTIC Science & Technology

    2001-05-01

    relations. His articles and reviews have been published in Revista Iberoamericana, Journal of Interamerican Studies, Revista Espanola de Derecho ...programs (not an exception in the overall European picture), the pitching of Plan Colombia becomes the selling of the contribution of real and virtual...table for real negotiations beyond ceasefires and neutral zones. The matter may look differently as events following the talks between President

  14. Expansion and Enhacement of the Wyoming Coalbed Methane Clearinghouse Website to the Wyoming Energy Resources Information Clearinghouse.

    SciTech Connect

    Hulme, Diana; Hamerlinck, Jeffrey; Bergman, Harold; Oakleaf, Jim

    2010-03-25

    Energy development is expanding across the United States, particularly in western states like Wyoming. Federal and state land management agencies, local governments, industry and non-governmental organizations have realized the need to access spatially-referenced data and other non-spatial information to determine the geographical extent and cumulative impacts of expanding energy development. The Wyoming Energy Resources Information Clearinghouse (WERIC) is a web-based portal which centralizes access to news, data, maps, reports and other information related to the development, management and conservation of Wyoming's diverse energy resources. WERIC was established in 2006 by the University of Wyoming's Ruckelshaus Institute of Environment and Natural Resources (ENR) and the Wyoming Geographic Information Science Center (WyGISC) with funding from the US Department of Energy (DOE) and the US Bureau of Land Management (BLM). The WERIC web portal originated in concept from a more specifically focused website, the Coalbed Methane (CBM) Clearinghouse. The CBM Clearinghouse effort focused only on coalbed methane production within the Powder River Basin of northeast Wyoming. The CBM Clearinghouse demonstrated a need to expand the effort statewide with a comprehensive energy focus, including fossil fuels and renewable and alternative energy resources produced and/or developed in Wyoming. WERIC serves spatial data to the greater Wyoming geospatial community through the Wyoming GeoLibrary, the WyGISC Data Server and the Wyoming Energy Map. These applications are critical components that support the Wyoming Energy Resources Information Clearinghouse (WERIC). The Wyoming GeoLibrary is a tool for searching and browsing a central repository for metadata. It provides the ability to publish and maintain metadata and geospatial data in a distributed environment. The WyGISC Data Server is an internet mapping application that provides traditional GIS mapping and analysis

  15. Contribution of anadromous fish to the diet of European catfish in a large river system

    NASA Astrophysics Data System (ADS)

    Syväranta, Jari; Cucherousset, Julien; Kopp, Dorothée; Martino, Aurélia; Céréghino, Régis; Santoul, Frédéric

    2009-05-01

    Many anadromous fish species, when migrating from the sea to spawn in fresh waters, can potentially be a valuable prey for larger predatory fish, thereby efficiently linking these two ecosystems. Here, we assess the contribution of anadromous fish to the diet of European catfish ( Silurus glanis) in a large river system (Garonne, southwestern France) using stable isotope analysis and allis shad ( Alosa alosa) as an example of anadromous fish. Allis shad caught in the Garonne had a very distinct marine δ13C value, over 8‰ higher after lipid extraction compared to the mean δ13C value of all other potential freshwater prey fish. The δ13C values of European catfish varied considerably between these two extremes and some individuals were clearly specializing on freshwater prey, whereas others specialized on anadromous fish. The mean contribution of anadromous fish to the entire European catfish population was estimated to be between 53% and 65%, depending on the fractionation factor used for δ13C.

  16. The Higher Education Clearinghouse for Space Sciences

    NASA Astrophysics Data System (ADS)

    Dalton, H.; Cobabe-Ammann, E. A.; Shipp, S. S.

    2011-12-01

    The Higher Education Clearinghouse (HECl) is a searchable database of undergraduate classroom materials for faculty teaching planetary sciences and solar and space physics at both the introductory and upper division levels. Modeled after the highly successful SERC clearinghouse for geosciences assets, HECl was designed for easy submission of classroom assets - from homeworks and computer interactives to laboratories and demonstrations. All materials are peer-reviewed before posting, and authors adhere to the Creative Commons Attribution (CC BY). HECl materials are automatically cross-posted to other digital libraries (e.g., ComPADRE) and virtual higher education communities (e.g., Connexions). In addition to classroom materials, HECl provides news and information about educational research and best practices, funding opportunities, and ongoing efforts and collaborations for undergraduate education.

  17. The Higher Education Clearinghouse for Space Sciences

    NASA Astrophysics Data System (ADS)

    Cobabe-Ammann, E. A.; Shipp, S. S.; Dalton, H.

    2011-12-01

    The Higher Education Clearinghouse (HECl) is a searchable database of undergraduate classroom materials for faculty teaching planetary sciences and solar and space physics at both the introductory and upper division levels. Modeled after the highly successful SERC clearinghouse for geosciences assets, HECl was designed for easy submission of classroom assets - from homeworks and computer interactives to laboratories and demonstrations. All materials are peer-reviewed before posting, and authors adhere to the Creative Commons Attribution (CC BY). HECl materials are automatically cross-posted to other digital libraries (e.g., ComPADRE) and virtual higher education communities (e.g., Connexions). In addition to classroom materials, HECl provides news and information about educational research and best practices, funding opportunities, and ongoing efforts and collaborations for undergraduate education.

  18. European contribution to the last glacial dust cycle: how loess sequences were built

    NASA Astrophysics Data System (ADS)

    Rousseau, D.; Chauvel, C.; Sima, A.

    2013-12-01

    When studying the past variations of the dust climate cycle, an important source of uncertainty are the emissions from sources which were active in glacial times (due to lower sea level, dryer and windier climate, reduced vegetation etc), but are not anymore in present day. A better agreement between results from numerical simulations and the available data for the Last Glacial Maximum has recently been obtained by taking into account the contribution of glaciogenic dust sources (i.e., areas following the continental ice-sheet margins, rich in easily deflatable material produced by glacier-related processes). The extent and relative contribution of the different types of dust sources (desert, glaciogenic) have varied during the past glacial cycles, and their relative impact on deposition also varied from one deposition area to another. Thus, when attempting to interpret dust deposition records in terms of climate change, the corresponding dust sources need to be well identified. Here we address the North Atlantic abrupt climate changes ("Greenland stadial-interstadial cycles"), which have largely impacted Europe especially during marine isotope stage (MIS) 3 and 2, from the perspective of European loess deposits. Using geochemical data analyses on loess sequences located along the 50°N latitude, and numerical dust emision simulations at an appropriately high spatial resolution, we identify the main emission sources relevant for the different deposition areas, and mechanisms contributing to the sedimentation rate variations in the European MIS 3 and 2 loess sequences.

  19. Bringing the environment in: early Central European contributions to an ecologically oriented psychology of perception.

    PubMed

    Radler, Jan

    2015-11-01

    This article explores the Central European philosophical roots of perceptual psychology from a historical perspective. It will be shown that Alexius Meinong's notion of a forum of perception is the point of departure for a beginning inclusion of external factors in explaining perception. This conclusion is mainly because of Fritz Heider's early contributions on perception and its influence on Egon Brunswik. In addition, the impact of Meinong and Edmund Husserl-both students of Franz Brentano-on Brunswik's teacher, Karl Bühler, is highlighted.

  20. EUROPEAN CONTRIBUTION TO RESEARCH ON AYURVEDA - WORK OF J.FILLIOZAT, G.J. MEULENBELD, R.E. EMMERICK

    PubMed Central

    Liyanaratne, Jinadasa

    1998-01-01

    This paper is the adaptation of a talk given by the author at the University of Kelaniya (Sri Lanka) on 29 September 1998 on three European scholars who have made a signal contribution to philological studies of Ayurveda. PMID:22556875

  1. Contribution of Meat Inspection to the surveillance of poultry health and welfare in the European Union.

    PubMed

    Huneau-Salaün, A; Stärk, K D C; Mateus, A; Lupo, C; Lindberg, A; LE Bouquin-Leneveu, S

    2015-08-01

    In the European Union, Meat Inspection (MI) aims to protect public health by ensuring that minimal hazardous material enters in the food chain. It also contributes to the detection and monitoring of animal diseases and welfare problems but its utility for animal surveillance has been assessed partially for some diseases only. Using the example of poultry production, we propose a complete assessment of MI as a health surveillance system. MI allows a long-term syndromic surveillance of poultry health but its contribution is lowered by a lack of data standardization, analysis and reporting. In addition, the probability of case detection for 20 diseases and welfare conditions was quantified using a scenario tree modelling approach, with input data based on literature and expert opinion. The sensitivity of MI appeared to be very high to detect most of the conditions studied because MI is performed at batch level and applied to a high number of birds per batch.

  2. 45 CFR 162.414 - Implementation specifications: Health care clearinghouses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Implementation specifications: Health care... for Health Care Providers § 162.414 Implementation specifications: Health care clearinghouses. A health care clearinghouse must use the NPI of any health care provider (or subpart(s), if...

  3. What Works Clearinghouse[TM] Reporting Guide for Study Authors

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2012

    2012-01-01

    This document provides guidance about how to describe studies and report their findings in a way that is clear, complete, and transparent. This document does not include information about how studies are judged against What Works Clearinghouse evidence standards. For information about What Works Clearinghouse evidence standards, please refer to…

  4. Computer Applications to ERIC Clearinghouse Document Collections: A Final Report.

    ERIC Educational Resources Information Center

    Magisos, Joel H.; Berkebile, Lonnie A.

    The purpose of this project was to develop computer techniques for the production of VT-ERIC publications and to report these techniques so that they might be used by other ERIC Clearinghouses for production of their publications. The Clearinghouse needed to: (1) generate bibliographies from its own collection upon which to base information…

  5. The ERIC Clearinghouse on Assessment and Evaluation, 1995 Annual Report.

    ERIC Educational Resources Information Center

    ERIC Clearinghouse on Assessment and Evaluation, Washington, DC.

    The Clearinghouse on Assessment and Evaluation of the Educational Resources Information Center (ERIC) is one of the 16 subject-oriented clearinghouses operated by the U.S. Department of Education, Office of Educational Research and Improvement. In its early years, ERIC was primarily an archive of education literature, but is has evolved into a…

  6. 45 CFR 162.414 - Implementation specifications: Health care clearinghouses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Implementation specifications: Health care... for Health Care Providers § 162.414 Implementation specifications: Health care clearinghouses. A health care clearinghouse must use the NPI of any health care provider (or subpart(s), if applicable...

  7. 45 CFR 162.414 - Implementation specifications: Health care clearinghouses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Implementation specifications: Health care... for Health Care Providers § 162.414 Implementation specifications: Health care clearinghouses. A health care clearinghouse must use the NPI of any health care provider (or subpart(s), if applicable...

  8. Outlook of possible European contributions to future exploration scenarios and architectures

    NASA Astrophysics Data System (ADS)

    Perino, M. A.; Fenoglio, F.; Pelle, S.; Couzin, P.; Thaeter, J.; Eilingsfeld, F.; Hufenbach, B.; Bergamasco, A.

    2013-07-01

    Building upon the important experience acquired with the development of the International Space Station, the major spacefaring countries are working within the International Space Exploration Coordination Group (ISECG) at the definition of a coordinated framework for expanding the human presence beyond the Low Earth Orbit, the Global Exploration Roadmap (GER). The GER defines a long-range strategy for global exploration and include three major elements. Common goals of ISECG participating agencies for space exploration. Notional mission scenarios which are technically feasible and programmatically implementable. Two mission scenarios were defined in the 1st iteration of the GER: the "Asteroid Next" and the "Moon Next" mission scenarios. Identification of near-term opportunities for coordination and cooperation related to e.g. the development of technologies, the implementation of robotic missions to destination of interest for closing strategic knowledge gaps which need to be addressed prior to human missions as well as the utilization of ISS for demonstration of exploration enabling capabilities. In 2009 two studies have been awarded by ESA to Industrial Teams led by Thales Alenia Space—Italy and by Astrium—Germany to define, analyze and assess optional European scenarios for future human spaceflight and exploration activities, and to derive the required capabilities for the investigated timeframe until the year 2033. Work on the European scenarios has been aligned with and informed by the international work on the GER. A conceptual design of different Building Block Elements, representing critical contributions to international Design Reference Missions (DRM's) included in the ISECG GER, has been performed and analyzed with respect to programmatic risks, budgets and required technologies. Key driving requirements for the analyzed Building Block elements have been derived from the international DRM's included in the GER. The interim outcomes of the human

  9. What contributes to disparities in the preterm birth rate in European countries?

    PubMed Central

    Delnord, Marie; Blondel, Béatrice; Zeitlin, Jennifer

    2015-01-01

    Purpose of review In countries with comparable levels of development and healthcare systems, preterm birth rates vary markedly – a range from 5 to 10% among live births in Europe. This review seeks to identify the most likely sources of heterogeneity in preterm birth rates, which could explain differences between European countries. Recent findings Multiple risk factors impact on preterm birth. Recent studies reported on measurement issues, population characteristics, reproductive health policies as well as medical practices, including those related to subfertility treatments and indicated deliveries, which affect preterm birth rates and trends in high-income countries. We showed wide variation in population characteristics, including multiple pregnancies, maternal age, BMI, smoking, and percentage of migrants in European countries. Summary Many potentially modifiable population factors (BMI, smoking, and environmental exposures) as well as health system factors (practices related to indicated preterm deliveries) play a role in determining preterm birth risk. More knowledge about how these factors contribute to low and stable preterm birth rates in some countries is needed for shaping future policy. It is also important to clarify the potential contribution of artifactual differences owing to measurement. PMID:25692506

  10. Euro-Argo: The European contribution to the global Argo ocean observations network

    NASA Astrophysics Data System (ADS)

    Gourcuff, Claire

    2017-04-01

    The international Argo programme is a major element of the global in-situ ocean observing system. More than 3900 floats are now globally measuring temperature and salinity throughout the global oceans, down to 2,000 meters depth and delivering data both in real time for operational users and after careful scientific quality control for climate change research and monitoring. Argo is the single most important in-situ observing system for the Copernicus Marine Service. The Euro-Argo research infrastructure organizes and federates European contribution to Argo. A legal and governance framework (Euro-Argo ERIC) was set up in May 2014; it allows European countries to consolidate and improve their contribution to Argo international. We will provide an overview of the development of Euro-Argo over the past years and present the now agreed Euro-Argo long term organization. The capability of the Euro-Argo infrastructure to organize Argo floats procurement, deployment and processing at European level and to conduct R&D driven by Copernicus needs will be highlighted. During the recent years, within the H2020 E-AIMS project, Euro-Argo carried R&D activities on new Argo floats, equipped with biogeochemical sensors or able to dive up to 4000m, from the floats design up to the analysis of their measurements. European Argo data centers were adapted so that they can handle the new data. Observing System Evaluations and Simulation Experiments were also conducted to provide robust recommendations for the next phase of Argo. One of the main challenges for Euro-Argo is now to implement the next phase of Argo with an extension towards biogeochemistry (e.g. oxygen, biology), the polar oceans, the marginal seas and the deep ocean. Meeting such challenges is essential for the long term sustainability and evolution of the Copernicus Marine Service. We will present Euro-Argo strategy and provide some highlights on the implementation-plan for the years to come and the Argo extensions for the

  11. Independent introductions and admixtures have contributed to adaptation of European maize and its American counterparts

    PubMed Central

    Brandenburg, Jean-Tristan; Mary-Huard, Tristan; Rigaill, Guillem; Corti, Hélène; Vitte, Clémentine; Charcosset, Alain; Tenaillon, Maud I.

    2017-01-01

    Through the local selection of landraces, humans have guided the adaptation of crops to a vast range of climatic and ecological conditions. This is particularly true of maize, which was domesticated in a restricted area of Mexico but now displays one of the broadest cultivated ranges worldwide. Here, we sequenced 67 genomes with an average sequencing depth of 18x to document routes of introduction, admixture and selective history of European maize and its American counterparts. To avoid the confounding effects of recent breeding, we targeted germplasm (lines) directly derived from landraces. Among our lines, we discovered 22,294,769 SNPs and between 0.9% to 4.1% residual heterozygosity. Using a segmentation method, we identified 6,978 segments of unexpectedly high rate of heterozygosity. These segments point to genes potentially involved in inbreeding depression, and to a lesser extent to the presence of structural variants. Genetic structuring and inferences of historical splits revealed 5 genetic groups and two independent European introductions, with modest bottleneck signatures. Our results further revealed admixtures between distinct sources that have contributed to the establishment of 3 groups at intermediate latitudes in North America and Europe. We combined differentiation- and diversity-based statistics to identify both genes and gene networks displaying strong signals of selection. These include genes/gene networks involved in flowering time, drought and cold tolerance, plant defense and starch properties. Overall, our results provide novel insights into the evolutionary history of European maize and highlight a major role of admixture in environmental adaptation, paralleling recent findings in humans. PMID:28301472

  12. Independent introductions and admixtures have contributed to adaptation of European maize and its American counterparts.

    PubMed

    Brandenburg, Jean-Tristan; Mary-Huard, Tristan; Rigaill, Guillem; Hearne, Sarah J; Corti, Hélène; Joets, Johann; Vitte, Clémentine; Charcosset, Alain; Nicolas, Stéphane D; Tenaillon, Maud I

    2017-03-01

    Through the local selection of landraces, humans have guided the adaptation of crops to a vast range of climatic and ecological conditions. This is particularly true of maize, which was domesticated in a restricted area of Mexico but now displays one of the broadest cultivated ranges worldwide. Here, we sequenced 67 genomes with an average sequencing depth of 18x to document routes of introduction, admixture and selective history of European maize and its American counterparts. To avoid the confounding effects of recent breeding, we targeted germplasm (lines) directly derived from landraces. Among our lines, we discovered 22,294,769 SNPs and between 0.9% to 4.1% residual heterozygosity. Using a segmentation method, we identified 6,978 segments of unexpectedly high rate of heterozygosity. These segments point to genes potentially involved in inbreeding depression, and to a lesser extent to the presence of structural variants. Genetic structuring and inferences of historical splits revealed 5 genetic groups and two independent European introductions, with modest bottleneck signatures. Our results further revealed admixtures between distinct sources that have contributed to the establishment of 3 groups at intermediate latitudes in North America and Europe. We combined differentiation- and diversity-based statistics to identify both genes and gene networks displaying strong signals of selection. These include genes/gene networks involved in flowering time, drought and cold tolerance, plant defense and starch properties. Overall, our results provide novel insights into the evolutionary history of European maize and highlight a major role of admixture in environmental adaptation, paralleling recent findings in humans.

  13. Contribution of higher risk genes and European admixture to Crohn's disease in African Americans

    PubMed Central

    Wang, Ming-Hsi; Okazaki, Toshihiko; Kugathasan, Subra; Cho, Judy H.; Isaacs, Kim L.; Lewis, James D.; Smoot, Duane T.; Valentine, John F.; Kader, Howard A.; Ford, Jean G.; Harris, Mary L.; Oliva-Hemker, Maria; Cuffari, Carmen; Torbenson, Michael S.; Duerr, Richard H.; Silverberg, Mark S.; Rioux, John D.; Taylor, Kent D.; Nguyen, Geoffrey C.; Wu, Yuqiong; Datta, Lisa W.; Hooker, Stanley; Dassopoulos, Themistocles; Kittles, Rick A.; Kao, Linda W.H.; Brant, Steven R.

    2012-01-01

    Background & Aims African Americans (AA) are an admixed population of West African (WA) and European ancestry (EA). Crohn's disease (CD) susceptibility genes have not been established. We therefore evaluated the contribution of European admixture and major established risk genes to AA CD. Methods Ninety-seven admixture informative markers were genotyped for ancestry estimates using STRUCTURE. 354 AA CD cases and 354 ethnicity-matched controls were genotyped for total 21 SNPs in ATG16L1, NOD2, IBD5, IL23R and IRGM by TaqMan or direct sequencing. Association was evaluated by logistic regression, adjusted for ancestry. Results Mean EA was similar among the CD cases and controls (20.9% and 20.4, respectively, p=0.58). No significant admixture differences were observed among cases (211 to 227) stratified by phenotypic sub-classifications including onset, surgery, site, and behavior. CD was associated with NOD2 carrier (6.93% CD, 2.15% Controls, p = 0.007), ATG16L1 Thr300Ala (36.1% CD, 29.3% Controls, p=0.003), SLC22A4 and SLC22A5 (IBD5 locus) functional SNPs (L503F [10.6% CD, 7.6% Controls, p=0.05] and g-207c [41.3% CD, 35.7% Controls, p=0.03], respectively) and IL23R rs2201841 (18.2% CD, 13.8% Controls, p=0.03), but not IRGM variants nor three African ancestral NOD2 nonsynonymous variants. IBD5 risk was recessive. An all-minor allele IBD5 haplotype from EA was associated (p=0.05), whereas a more common haplotype isolating g-207c was not. Conclusions Specific functional gene variations significantly contribute to AA CD risk. Established NOD2, SLC22A4-A5, and ATG16L1 variants show increased CD risk, with IBD5 in recessive. Although CD is more common in whites, European admixture is similar among AA cases and controls. PMID:22411504

  14. The Contribution of European Vocational Training Policy to Reforms in the Partner Countries of the European Union

    ERIC Educational Resources Information Center

    Masson, Jean-Raymond

    2007-01-01

    This article provides an overview of recent developments in EU vocational education and training (VET) policy, and of the issues and challenges faced by VET systems in the Western Balkans, Turkey, and other countries covered by the "wider European neighbourhood" policy. The purpose is to emphasise the relevance for these countries of the…

  15. Source-sector contributions to European ozone and fine PM in 2010 using AQMEII modeling data

    NASA Astrophysics Data System (ADS)

    Karamchandani, Prakash; Long, Yoann; Pirovano, Guido; Balzarini, Alessandra; Yarwood, Greg

    2017-05-01

    Source apportionment modeling provides valuable information on the contributions of different source sectors and/or source regions to ozone (O3) or fine particulate matter (PM2.5) concentrations. This information can be useful in designing air quality management strategies and in understanding the potential benefits of reducing emissions from a particular source category. The Comprehensive Air quality Model with Extensions (CAMx) offers unique source attribution tools, called the Ozone and Particulate Source Apportionment Technology (OSAT/PSAT), which track source contributions. We present results from a CAMx source attribution modeling study for a summer month and a winter month using a recently evaluated European CAMx modeling database developed for Phase 3 of the Air Quality Model Evaluation International Initiative (AQMEII). The contributions of several source sectors (including model boundary conditions of chemical species representing transport of emissions from outside the modeling domain as well as initial conditions of these species) to O3 or PM2.5 concentrations in Europe were calculated using OSAT and PSAT, respectively. A 1-week spin-up period was used to reduce the influence of initial conditions. Evaluation focused on 16 major cities and on identifying source sectors that contributed above 5 %. Boundary conditions have a large impact on summer and winter ozone in Europe and on summer PM2.5, but they are only a minor contributor to winter PM2.5. Biogenic emissions are important for summer ozone and PM2.5. The important anthropogenic sectors for summer ozone are transportation (both on-road and non-road), energy production and conversion, and industry. In two of the 16 cities, solvent and product also contributed above 5 % to summertime ozone. For summertime PM2.5, the important anthropogenic source sectors are energy, transportation, industry, and agriculture. Residential wood combustion is an important anthropogenic sector in winter for PM2.5 over

  16. Contribution of dietary starch to hepatic and systemic carbohydrate fluxes in European seabass (Dicentrarchus labrax L.).

    PubMed

    Viegas, Ivan; Rito, João; Jarak, Ivana; Leston, Sara; Caballero-Solares, Albert; Metón, Isidoro; Pardal, Miguel A; Baanante, Isabel V; Jones, John G

    2015-05-14

    In the present study, the effects of partial substitution of dietary protein by digestible starch on endogenous glucose production were evaluated in European seabass (Dicentrarchus labrax). The fractional contribution of dietary carbohydrates v. gluconeogenesis to blood glucose appearance and hepatic glycogen synthesis was quantified in two groups of seabass fed with a diet containing 30% digestible starch (DS) or without a carbohydrate supplement as the control (CTRL). Measurements were performed by transferring the fish to a tank containing water enriched with 5% (2)H2O over the last six feeding days, and quantifying the incorporation of (2)H into blood glucose and hepatic glycogen by (2)H NMR. For CTRL fish, gluconeogenesis accounted for the majority of circulating glucose while for the DS fish, this contribution was significantly lower (CTRL 85 (SEM 4) % v. DS 54 (SEM 2) %; P < 0.001). Hepatic glycogen synthesis via gluconeogenesis (indirect pathway) was also significantly reduced in the DS fish, in both relative (CTRL 100 (SEM 1) % v. DS 72 (SEM 1) %; P < 0.001) and absolute terms (CTRL 28 (SEM 1) v. DS 17 (sem 1) μmol/kg per h; P < 0.001). A major fraction of the dietary carbohydrates that contributed to blood glucose appearance (33 (sem 1) % of the total 47 (SEM 2) %) had undergone exchange with hepatic glucose 6-phosphate. This indicated the simultaneous activity of hepatic glucokinase and glucose 6-phosphatase. In conclusion, supplementation of digestible starch resulted in a significant reduction of gluconeogenic contributions to systemic glucose appearance and hepatic glycogen synthesis.

  17. Primary versus secondary contributions to particle number concentrations in the European boundary layer

    NASA Astrophysics Data System (ADS)

    Reddington, C. L.; Carslaw, K. S.; Spracklen, D. V.; Frontoso, M. G.; Collins, L.; Merikanto, J.; Minikin, A.; Hamburger, T.; Coe, H.; Kulmala, M.; Aalto, P.; Flentje, H.; Plass-Dülmer, C.; Birmili, W.; Wiedensohler, A.; Wehner, B.; Tuch, T.; Sonntag, A.; O'Dowd, C. D.; Jennings, S. G.; Dupuy, R.; Baltensperger, U.; Weingartner, E.; Hansson, H.-C.; Tunved, P.; Laj, P.; Sellegri, K.; Boulon, J.; Putaud, J.-P.; Gruening, C.; Swietlicki, E.; Roldin, P.; Henzing, J. S.; Moerman, M.; Mihalopoulos, N.; Kouvarakis, G.; Ždímal, V.; Zíková, N.; Marinoni, A.; Bonasoni, P.; Duchi, R.

    2011-06-01

    It is important to understand the relative contribution of primary and secondary particles to regional and global aerosol so that models can attribute aerosol radiative forcing to different sources. In large-scale models, there is considerable uncertainty associated with treatments of particle formation (nucleation) in the boundary layer (BL) and in the size distribution of emitted primary particles, leading to uncertainties in predicted cloud condensation nuclei (CCN) concentrations. Here we quantify how primary particle emissions and secondary particle formation influence size-resolved particle number concentrations in the BL using a global aerosol microphysics model and observations made during the May 2008 campaign of the European Integrated Project on Aerosol Cloud Climate Air Quality Interactions (EUCAARI). Observations are available from the DLR Falcon 20 aircraft and from 15 ground sites of the European Supersites for Atmospheric Aerosol Research (EUSAAR) and the German Ultrafine Aerosol Network (GUAN). Measurements include total and non-volatile particle number concentrations and the particle size distribution between ~3 nm and ~1 μm. We tested four different parameterisations for BL nucleation and two assumptions for the emission size distribution of anthropogenic and wildfire carbonaceous particles. When we emit small carbonaceous particles (recommended by the Aerosol Intercomparison project, AEROCOM), the spatial distributions of campaign-mean number concentrations >50 nm (N50) and >100 nm (N100) dry diameter were well captured by the model (R2~0.9) and the normalised mean bias (NMB) was also small (-5 % for N50 and 12 % for N100). Emission of larger particles, which we consider to be more realistic for global models, results in equally good correlation but larger bias (R2~0.8, NMB = -51 % and -21 %), which could be partly but not entirely compensated by BL nucleation. The model also predicts the particle concentration frequency distribution fairly

  18. Advanced reprocessing developments in Europe contribution of European projects ACSEPT and ACTINET-I3

    SciTech Connect

    Bourg, S.; Poinssot, C.; Geist, A.; Cassayre, L.; Rhodes, C.; Ekberg, C.

    2012-07-01

    Nuclear energy has more than ever to demonstrate that it can contribute safely and on a sustainable way to answer the international increase in energy needs. Actually, in addition to an increased safety of the reactors themselves, its acceptance is still closely associated to our capability to reduce the lifetime of the nuclear waste, to manage them safely and to propose options for a better use of the natural resources. Spent fuel reprocessing can help to reach these objectives. But this cannot be achieved only by optimizing industrial processes through engineering studies. It is of a primary importance to increase our fundamental knowledge in actinide sciences in order to build the future of nuclear energy on reliable and scientifically-founded results, and therefore meet the needs of the future fuel cycles in terms of fabrication and performance of fuels, reprocessing and waste management. At the European level, both the collaborative project ACSEPT and the Integrated Infrastructure Initiative ACTINET-I3 work together to improve our knowledge in actinides chemistry and therefore develop advanced separation processes. These tools are complementary and work in close connection on some specific issues such as the understanding of the selectivity of extracting organic ligands. By offering trans-national access to the main nuclear research facility in Europe, ACTINET-I3 aims at increasing the knowledge in actinide sciences by gathering all the expertise available in European nuclear research institutes or university and giving them the opportunity to come and work in hot-labs (ITU, Atalante...) or beamlines (ESFR, ANKA, PSI) ACSEPT is focused on the development of advanced separation processes, both aqueous and pyrochemical. Head-end steps, fuel re-fabrication, solvent treatment, waste management are also taken into account. In aqueous process development, the SANEX and innovative SANEX flowsheets demonstration were successfully achieved. Chemical systems were

  19. The contribution of the European Society for Soil Conservation (ESSC) to scientific knowledge, education and sustainability

    NASA Astrophysics Data System (ADS)

    Dazzi, Carmelo; Fullen, Michael A.; Costantini, Edoardo A. C.; Theocharopoulos, Sid; Rickson, Jane; Kasparinskis, Raimonds; Lo Papa, Giuseppe; Peres, Guenola; Sholten, Thomas; Kertész, Adam; Vasenev, Ivan; Dumitru, Mihail; Cornelis, Wim; Rubio, José L.

    2017-04-01

    Soil is an integral component of the global environmental system that supports the quality and diversity of terrestrial life on Earth. Therefore, it is vital to consider the processes and impacts of soil degradation on society, especially on the provision of environmental goods and services, including food security and climate change mitigation and adaptation. Scientific societies devoted to Soil Science play significant roles in promoting soil security by advancing scientific knowledge, education and environmental sustainability. The European Society for Soil Conservation (ESSC) was founded in Ghent (Belgium) on 4 November 1988 by a group of 23 researchers from several European countries. It is an interdisciplinary, non-political association with over 500 members in 56 countries. The ESSC produces and distributes a hardcopy Newsletter twice a year and maintains both a website and Facebook page: http://www.soilconservation.eu/ https://www.facebook.com/European-Society-for-Soil-Conservation-ESSC-100528363448094/ The ESSC aims to: • Support research on soil degradation, soil protection and soil and water conservation. • Provide a network for the exchange of knowledge about soil degradation processes and soil conservation research and practises. • Produce publications on major issues relating to soil degradation and soil and water conservation. • Advise regulators and policy-makers on soil issues, especially soil degradation, protection and conservation. The ESSC held its First International Congress in Silsoe (UK) in 1992. Further International Congresses were held in Munich (1996), Valencia (2000), Budapest (2004), Palermo (2007), Thessaloniki (2011) and Moscow (2015). The Eighth International Congress will be held in Lleida (Spain) in June 2017: http://www.consowalleida2017.com/ Interspersed between these international congresses, the ESSC organizes annual international conferences on specific topics. These include Imola, Italy (Biogeochemical Processes at

  20. Primary versus secondary contributions to particle number concentrations in the European boundary layer

    NASA Astrophysics Data System (ADS)

    Reddington, C. L.; Carslaw, K. S.; Spracklen, D. V.; Frontoso, M. G.; Collins, L.; Merikanto, J.; Minikin, A.; Hamburger, T.; Coe, H.; Kulmala, M.; Aalto, P.; Flentje, H.; Plass-Dülmer, C.; Birmili, W.; Wiedensohler, A.; Wehner, B.; Tuch, T.; Sonntag, A.; O'Dowd, C. D.; Jennings, S. G.; Dupuy, R.; Baltensperger, U.; Weingartner, E.; Hansson, H.-C.; Tunved, P.; Laj, P.; Sellegri, K.; Boulon, J.; Putaud, J.-P.; Gruening, C.; Swietlicki, E.; Roldin, P.; Henzing, J. S.; Moerman, M.; Mihalopoulos, N.; Kouvarakis, G.; Ždímal, V.; Zíková, N.; Marinoni, A.; Bonasoni, P.; Duchi, R.

    2011-12-01

    It is important to understand the relative contribution of primary and secondary particles to regional and global aerosol so that models can attribute aerosol radiative forcing to different sources. In large-scale models, there is considerable uncertainty associated with treatments of particle formation (nucleation) in the boundary layer (BL) and in the size distribution of emitted primary particles, leading to uncertainties in predicted cloud condensation nuclei (CCN) concentrations. Here we quantify how primary particle emissions and secondary particle formation influence size-resolved particle number concentrations in the BL using a global aerosol microphysics model and aircraft and ground site observations made during the May 2008 campaign of the European Integrated Project on Aerosol Cloud Climate Air Quality Interactions (EUCAARI). We tested four different parameterisations for BL nucleation and two assumptions for the emission size distribution of anthropogenic and wildfire carbonaceous particles. When we emit carbonaceous particles at small sizes (as recommended by the Aerosol Intercomparison project, AEROCOM), the spatial distributions of campaign-mean number concentrations of particles with diameter >50 nm (N50) and >100 nm (N100) were well captured by the model (R2≥0.8) and the normalised mean bias (NMB) was also small (-18% for N50 and -1% for N100). Emission of carbonaceous particles at larger sizes, which we consider to be more realistic for low spatial resolution global models, results in equally good correlation but larger bias (R2≥0.8, NMB = -52% and -29%), which could be partly but not entirely compensated by BL nucleation. Within the uncertainty of the observations and accounting for the uncertainty in the size of emitted primary particles, BL nucleation makes a statistically significant contribution to CCN-sized particles at less than a quarter of the ground sites. Our results show that a major source of uncertainty in CCN-sized particles in

  1. Instructional Conversations and Literature Logs. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2006

    2006-01-01

    This What Works Clearinghouse (WWC) report examines the effect of "Instructional Conversations and Literature Logs" used in combination. The goal of "Instructional Conversations" is to help English language learners develop reading comprehension ability along with English language proficiency. "Instructional…

  2. 78 FR 41694 - Final Priority and Requirements; Education Facilities Clearinghouse

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION 34 CFR Chapter II Final Priority and Requirements; Education Facilities Clearinghouse AGENCY: Office of Elementary and Secondary Education, Department of Education. ACTION: Final priority and requirements. SUMMARY...

  3. 19 CFR 24.25 - Statement processing and Automated Clearinghouse.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... cash. A mixing of payment methods for a single statement will not be accepted. ACH debit (see paragraph... with a single payment. The preferred method of payment is by Automated Clearinghouse (ACH) debit or ACH...

  4. The perspective of European researchers of national occupational safety and health institutes for contributing to a European research agenda: a modified Delphi study.

    PubMed

    Gagliardi, Diana; Rondinone, Bruna M; Mirabile, Marco; Buresti, Giuliana; Ellwood, Peter; Hery, Michel; Paszkiewicz, Peter; Valenti, Antonio; Iavicoli, Sergio

    2017-06-23

    This study, developed within the frame of the Partnership for European Research on Occupational Safety and Health joint research activities and based on the frame designed by the 2013 European Agency for Safety and Health at Work (EU-OSHA) study, is the first example of using the points of view of European occupational safety and health (OSH) researchers.The objective is to identify priorities for OSH research that may contribute to the achievement of present and future sustainable growth objectives set by the European strategies. The study was carried out using a modified Delphi method with a two-round survey. Each round involved a panel of about 110 researchers representing the network member institutes was selected according to specific criteria, including the ownership of research expertise in at least one of the four macroareas identified by the reference report developed by EU-OSHA in 2013. The study identified some innovative research topics (for example, 'Emerging technological devices' and 'OSH consequences of markets integration') and research priorities (ie, crowdsourcing, e-work, zero-hours contracts) that are not reflected in previous studies of this nature.The absence of any reference to violence and harassment at work among the researchers' proposals is a major difference from previous similar studies, while topics related to gender issues and electromagnetic fields show a lower importance. The innovative design of a research priorities identification process, which takes advantage of a large, representative and qualified panel of European researchers allowed the definition of a number of research priorities able to support the inclusion of innovative OSH research issues in the scope of the next European research agenda. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  5. The Contribution of Local and Regional Sources to Particulate Matter in European Megacities

    NASA Astrophysics Data System (ADS)

    Skyllakou, Ksakousti; Megaritis, Athanasios; Fountoukis, Christos; Murphy, Benjamin; Pandis, Spyros

    2013-04-01

    The ongoing urbanization over the past decade has led to an increasing number of Megacities around the world, now hosting more than half of the world's population (UN 2007). These large urban centers are substantial sources of anthropogenic pollutants having adverse effects on human health, visibility and ecosystems (Seinfeld and Pandis, 2006). In order to improve air quality in those urban areas we need to quantify the fraction of the pollution originating from local and regional sources and to determine the response of the system to emission controls. Three-dimensional chemical transport models (CTMs) are well suited to help address these source receptor questions since they model all the necessary processes that impact air pollution concentrations and transport in the domain. In this study we applied PMCAMx (Fountoukis et al., 2011) a three dimensional CTM over Europe to study the influence that emissions in large European urban areas (eg. Paris, London, etc.) might have on the concentration of the major PM2.5 components during a summer and a winter period. We combined PMCAMx with the Particulate Source Apportionment Technology (PSAT) (Wagstrom et al., 2011) which directly computes the contribution of different emission areas or source types. The contributions of local, short, medium, and long range transport and different source categories (e.g., transport, fires, etc.) were quantified. Local emission sources are predicted to have a significant effect on primary pollutant levels, like black carbon (BC) while secondary pollutants concentrations are dominated by sources outside the major urban areas. The PSAT results were compared with those of an "annihilation" scenario zeroing out all anthropogenic emissions over an urban area. The results of these simulations suggest that the two methods show a good agreement with each other, but PSAT is a lot more computationally efficient. References Fountoukis C., Racherla P. N., Denier van der Gon H. A. C., Polymeneas P

  6. Genetic and environmental contributions to initiation of cigarette smoking in young African-American and European-American women.

    PubMed

    Sartor, Carolyn E; Grant, Julia D; Agrawal, Arpana; Sadler, Brooke; Madden, Pamela A F; Heath, Andrew C; Bucholz, Kathleen K

    2015-12-01

    Distinctions in the relative contributions of genetic and environmental factors to initiation of cigarette smoking may explain, in part, the differences between African Americans and European Americans in the prevalence of smoking. The current investigation is the first to compare heritable and environmental influences on smoking initiation between African-American and European-American women. Data were drawn from Missouri Adolescent Female Twin Study participants and female Missouri Family Study participants (n=4498; 21% African-American, the remainder European-American). Mean ages at first and last assessments were 17.0 (SD=3.5) and 24.0 (SD=3.2), respectively. Twin-sibling modeling was conducted to estimate the proportion of variance in smoking initiation (i.e., ever trying a cigarette) attributable to additive genetic, shared environmental, special twin environmental, and unique environmental factors. Additive genetic influences accounted for approximately half of the variance in smoking initiation in both African-American and European-American women. In the African-American subsample, the remaining variance was attributable primarily to unique environmental factors (46%; 95% CI: 28-71%). In the European-American subsample, only 12% (95% CI: 8-16%) of the variance was attributable to unique environmental factors, with the remainder accounted for by shared environmental (13%; 95% CI: 0-41%) and special twin environmental (24%; 95% CI: 0-52%) factors. The estimated heritability of smoking initiation is substantial and nearly identical for African-American and European-American women, but the type of environmental factors that contribute to risk differ by race/ethnicity. Whereas the primary environmental influences on European-American women's smoking initiation are at the family level, those that impact African-American women's smoking initiation are primarily individual-specific. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  7. 45 CFR 162.930 - Additional rules for health care clearinghouses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Additional rules for health care clearinghouses... Additional rules for health care clearinghouses. When acting as a business associate for another covered entity, a health care clearinghouse may perform the following functions: (a) Receive a standard...

  8. 45 CFR 162.930 - Additional rules for health care clearinghouses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Additional rules for health care clearinghouses... Additional rules for health care clearinghouses. When acting as a business associate for another covered entity, a health care clearinghouse may perform the following functions: (a) Receive a standard...

  9. 45 CFR 162.930 - Additional rules for health care clearinghouses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Additional rules for health care clearinghouses... Additional rules for health care clearinghouses. When acting as a business associate for another covered entity, a health care clearinghouse may perform the following functions: (a) Receive a standard...

  10. 45 CFR 162.930 - Additional rules for health care clearinghouses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Additional rules for health care clearinghouses... Additional rules for health care clearinghouses. When acting as a business associate for another covered entity, a health care clearinghouse may perform the following functions: (a) Receive a standard...

  11. 45 CFR 162.930 - Additional rules for health care clearinghouses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Additional rules for health care clearinghouses... Additional rules for health care clearinghouses. When acting as a business associate for another covered entity, a health care clearinghouse may perform the following functions: (a) Receive a standard...

  12. EMANI, ERAM and Other European Activities Contributing to a Global Digital Library in Mathematics.

    NASA Astrophysics Data System (ADS)

    Wegner, Bernd

    capturing the content of a classical bibliographic service in mathematics in a database, and combining this with the retro-digitisation of selected mathematical publications. This is extended now by further projects which shall try to retro-digitise the national mathematical heritage in several countries world-wide. In particular ideas to cover the Russian publications in a digital repository called RusDLM are investigated at present, and they may contribute to a bigger programme for the Russian Federation, called "Electronic Russia", As further digitisation projects the French activity NUMDAM, pursued by Cellule MathDoc in Grenoble, and the European Cooperation in DIEPER have to be mentioned.

  13. Clearinghouse: a teleradiology platform emphasizing security of data and communication.

    PubMed

    Spitzer, Michael; Brinkmann, Lars; Ueckert, Frank

    2007-01-01

    The Clearinghouse application platform is a web based solution for secure digital exchange of radiological images and other clinical documents among authorized researchers and physicians. It implements a sophisticated security and role model to protect privacy and to minimize the risk of eavesdropping of patient data. The Clearinghouse serves as a centralized platform for distributed, distantly located medical research and health care. It is based on Open-Source software, thus ensuring continued support, maintenance, security and last but not least continuity of the platform. The use of the Clearinghouse minimizes turnaround times by superseding comparably slow and insecure conventional communication methods otherwise used for the exchange of radiological images and clinical documents, such as standard mail and courier services. Furthermore, it alleviates the integration of distantly located expert knowledge into diagnostic routines, culminating in an increased health care quality regardless of location of patients or physicians.

  14. The European Higher Education Area: An Interesting Opportunity to Contribute to Global Advancement

    ERIC Educational Resources Information Center

    Capa, Agueda Benito

    2012-01-01

    Universidad Europea de Madrid, along with other universities and the support of the Agency for Quality Assurance, Accreditation and Prospects for the Community of Madrid (ACAP--Agencia de Calidad, Acreditación y Prospectiva de las Universidades de Madrid), developed a tool to measure progress in the construction of the European Higher Education…

  15. Making sense of differing overdose mortality: contributions to improved understanding of European patterns.

    PubMed

    Waal, Helge; Gossop, Michael

    2014-01-01

    The European Monitoring Centre for Drugs and Drug Addiction, EMCDDA, publishes statistics for overdose deaths giving a European mean number, and ranking nations in a national 'league table' for overdose deaths. The interpretation of differing national levels of mortality is more problematic and more complex than is usually recognised. Different systems are used to compile mortality data and this causes problems for cross-national comparisons. Addiction behaviour can only be properly understood within its specific social and environmental ecology. Risk factors for overdose, such as the type of drug consumed, and the route of administration, are known to differ across countries. This paper describes problems associated with ranking and suggests how mortality data might be used in high-level countries aiming at reduction in the number of overdose deaths. Copyright © 2013 S. Karger AG, Basel.

  16. Unaccounted variability in NH3 agricultural sources detected by IASI contributing to European spring haze episode

    NASA Astrophysics Data System (ADS)

    Fortems-Cheiney, A.; Dufour, G.; Hamaoui-Laguel, L.; Foret, G.; Siour, G.; Van Damme, M.; Meleux, F.; Coheur, P.-F.; Clerbaux, C.; Clarisse, L.; Favez, O.; Wallasch, M.; Beekmann, M.

    2016-05-01

    Ammonia (NH3), whose main source in the troposphere is agriculture, is an important gaseous precursor of atmospheric particulate matter (PM). We derived daily ammonia emissions using NH3 total columns measured from the Infrared Atmospheric Sounding Interferometer (IASI) on board Metop-A, at a relatively high spatial resolution (grid cell of 0.5° × 0.5°). During the European spring haze episodes of 24-31 March 2012 and 8-15 March 2014, IASI reveals NH3 total column magnitudes highlighting higher NH3 emissions over central Europe (especially over Germany, Czech Republic, and eastern France) from the ones provided by the European reference European Monitoring and Evaluation Programme inventory. These ammonia emissions exhibit in addition a large day-to-day variability, certainly due to spreading practices. The increase of NH3 emissions in the model, that reaches +300% locally, leads to an increase of both NH3 and PM2.5 surface concentrations and allows for a better comparison with independent measurements (in terms of bias, root-mean-square error, and correlation). This study suggests that there are good prospects for better quantifying NH3 emissions by atmospheric inversions.

  17. 76 FR 34740 - Agency Information Collection Activities: Automated Clearinghouse

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Automated Clearinghouse AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION: 30-Day notice.... Customs and Border Protection (CBP) of the Department of Homeland Security will be submitting...

  18. Food and Agriculture Organization: A Clearinghouse for Agricultural Information.

    ERIC Educational Resources Information Center

    Joling, Carole

    1989-01-01

    Describes the functions of the United Nations Food and Agriculture Organization (FAO), which is an international clearinghouse for agricultural information. The discussion focuses on the information formats provided by the agency and the dissemination channels used for FAO information. Lists of finding aids for FAO materials and libraries…

  19. 36 CFR 72.51 - A-95 clearinghouse requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false A-95 clearinghouse requirements. 72.51 Section 72.51 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grant Selection, Approval and Administration §...

  20. 36 CFR 72.51 - A-95 clearinghouse requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false A-95 clearinghouse requirements. 72.51 Section 72.51 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grant Selection, Approval and Administration §...

  1. 36 CFR 72.51 - A-95 clearinghouse requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 1 2013-07-01 2013-07-01 false A-95 clearinghouse requirements. 72.51 Section 72.51 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grant Selection, Approval and Administration §...

  2. 36 CFR 72.51 - A-95 clearinghouse requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false A-95 clearinghouse requirements. 72.51 Section 72.51 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grant Selection, Approval and Administration §...

  3. 36 CFR 72.51 - A-95 clearinghouse requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false A-95 clearinghouse requirements. 72.51 Section 72.51 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR URBAN PARK AND RECREATION RECOVERY ACT OF 1978 Grant Selection, Approval and Administration §...

  4. Procedures and Version 2 Standards Handbook. What Works Clearinghouse

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2008

    2008-01-01

    This handbook describes the structure and processes that the What Works Clearinghouse (WWC) uses for its reviews, presenting in one place all the standards the WWC currently uses to assess research. The handbook will be revised as new standards are developed and major new features are finalized. A distinguishing feature of the WWC is that it does…

  5. Teach for America. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2016

    2016-01-01

    "Teach For America" ("TFA") is a highly selective route to teacher certification that aims to place non-traditionally trained teachers in high-need public schools. The What Works Clearinghouse (WWC) identified seven studies of teachers trained through "TFA" that both fall within the scope of the Teacher Training,…

  6. Methods of Quality Appraisal for Studies Reviewed by Evidence Clearinghouses

    ERIC Educational Resources Information Center

    Wilson, Sandra Jo; Tanner-Smith, Emily

    2015-01-01

    This presentation will discuss quality appraisal methods for assessing research studies used in systematic reviews, research syntheses, and evidence-based practice repositories such as the What Works Clearinghouse. The different ways that the methodological rigor and risk of bias of primary studies included in syntheses is assessed means that…

  7. Pivotal Response Training. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2016

    2016-01-01

    This intervention report presents findings from a systematic review of "pivotal response training" conducted using the What Works Clearinghouse Procedures and Standards Handbook (version 3.0) and the Children and Students with an Autism Spectrum Disorder review protocol (version 3.0). "Pivotal response training"…

  8. Academy of READING®. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2014

    2014-01-01

    "Academy of READING"® is an online program that aims to improve students' reading skills using a structured and sequential approach to learning in five core areas--phonemic awareness, phonics, fluency, vocabulary, and comprehension. The What Works Clearinghouse (WWC) identified 38 studies of "Academy of READING"® for adolescent…

  9. 45 CFR 162.414 - Implementation specifications: Health care clearinghouses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Implementation specifications: Health care clearinghouses. 162.414 Section 162.414 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS ADMINISTRATIVE REQUIREMENTS Standard Unique Health...

  10. Read Well[R]. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2010

    2010-01-01

    "Read Well"[R] is a reading curriculum for kindergarten and first-grade students whose goal is to increase students' literacy abilities. The program provides instruction in phonemic awareness, phonics, vocabulary, comprehension, and fluency. The What Works Clearinghouse (WWC) reviewed five studies on "Read Well"[R] for English…

  11. ERIC Clearinghouse on Adult Education; Publications, 1969-1970.

    ERIC Educational Resources Information Center

    Syracuse Univ., NY. ERIC Clearinghouse on Adult Education.

    Beginning with general information on the scope and subject coverage of the ERIC Clearinghouse on Adult Education (ERIC/AE) and on principal periodicals covering the literature, this annotated bibliography lists 74 literature reviews, research registers, ERIC/AE current and basic information sources, Central ERIC and Government Printing Office…

  12. Saxon Elementary School Math. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2006

    2006-01-01

    The What Works Clearinghouse (WWC) reviewed seven studies of the "Saxon Elementary School Math program." A distinguishing feature of "Saxon Elementary School Math" is its use of a distributed approach, as opposed to a chapter-based approach, for instruction and assessment. One of these studies met WWC standards with…

  13. Dream Box Learning. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2013

    2013-01-01

    "DreamBox Learning" is a supplemental online mathematics program that provides adaptive instruction for students in grades K-5 and focuses on number and operations, place value, and number sense. The What Works Clearinghouse (WWC) identified one study of "DreamBox Learning" that both falls within the scope of the Elementary…

  14. DreamBox Learning. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2013

    2013-01-01

    "DreamBox Learning" is a supplemental online mathematics program that provides adaptive instruction for students in grades K-5 and focuses on number and operations, place value, and number sense. The What Works Clearinghouse (WWC) identified one study of "DreamBox Learning" that both falls within the scope of the Elementary…

  15. First 3 years of the National AIDS Clearinghouse.

    PubMed

    Sinnock, P; Murphy, P E; Baker, T G; Bates, R

    1991-01-01

    The National AIDS Clearinghouse is an information service provided by the Centers for Disease Control. The Clearinghouse was established in 1987 to respond to increasing numbers of public and professional inquiries, to disseminate accurate information, and to make referrals to local sources of information and assistance. Four data bases--Resources and Services Database containing information about more than 16,000 organizations that provide counseling and testing for human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) and other education and prevention services; Educational Materials Database containing more than 8,000 individual, hard-to-find educational materials; Funding Database; and the AIDS Clinical Trial Information Service (ACTIS) Database--are searched by information specialists to respond to more than 45,000 requests annually for information from a variety of health professionals, organizations, and the general public. Between 1987 and 1991, the Clearinghouse disseminated more than 60 million copies of publications related to HIV and AIDS. Information and education remain the most critical tools for the prevention of HIV infection, and the National AIDS Clearinghouse provides an essential element for the dissemination of education and prevention information.

  16. 45 CFR 162.414 - Implementation specifications: Health care clearinghouses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Implementation specifications: Health care clearinghouses. 162.414 Section 162.414 Public Welfare Department of Health and Human Services ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS ADMINISTRATIVE REQUIREMENTS Standard Unique Health Identifier...

  17. 13 CFR 302.11 - Economic development information clearinghouse.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Economic development information clearinghouse. 302.11 Section 302.11 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL TERMS AND CONDITIONS FOR INVESTMENT ASSISTANCE § 302.11 Economic development...

  18. 13 CFR 302.11 - Economic development information clearinghouse.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Economic development information clearinghouse. 302.11 Section 302.11 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL TERMS AND CONDITIONS FOR INVESTMENT ASSISTANCE § 302.11 Economic development...

  19. 13 CFR 302.11 - Economic development information clearinghouse.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Economic development information clearinghouse. 302.11 Section 302.11 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL TERMS AND CONDITIONS FOR INVESTMENT ASSISTANCE § 302.11 Economic development...

  20. 13 CFR 302.11 - Economic development information clearinghouse.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Economic development information clearinghouse. 302.11 Section 302.11 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL TERMS AND CONDITIONS FOR INVESTMENT ASSISTANCE § 302.11 Economic development...

  1. 13 CFR 302.11 - Economic development information clearinghouse.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Economic development information clearinghouse. 302.11 Section 302.11 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE GENERAL TERMS AND CONDITIONS FOR INVESTMENT ASSISTANCE § 302.11 Economic development...

  2. Washington State's Corrections Clearinghouse: A Comprehensive Approach to Offender Employment.

    ERIC Educational Resources Information Center

    Finn, Peter

    Since 1976, the Correctional Clearinghouse (CCH), which is a unit of the Washington State Employment Security Department, has been committed to preparing offenders for the workplace and finding employment. The CCH's principal service delivery strategies are as follows: (1) providing direct services (teaching job readiness courses in prisons and…

  3. Building co-operative bibliographic databases in European bioethics: a contribution from EU New Member States.

    PubMed

    Dimec, Jure; Leskosek, Branimir

    2007-08-01

    The paper presents a web-based application, developed as a part of the Eurethnet database network, which is being used by project partners from EU New Member States to collect bibliographic records from bioethics domains. The application development was focused mainly on records compatibility with other Eurethnet databases, support for all European character sets, minimalisation of network traffic, and security issues. The time window available for the system development was very small and this problem was solved with our own software for automatic application generation.

  4. The History of Sounding Rockets and Their Contribution to European Space Research

    NASA Astrophysics Data System (ADS)

    Seibert, Günther

    2006-11-01

    The report describes the history of rocket development before and during the Second World War and their use as sounding rockets in Europe, the USA and the USSR, and outlines the technical, operational and scientific features of sounding rockets. The major European national sounding-rocket activities and those of ESRO from the early 1960s to the early 1970s are described, a period when sounding rockets represented an important part of space research. Over that time span, several hundred sounding rockets (up to 500 per year around 1970) were launched worldwide each year.

  5. Unaccounted variability in NH3 agricultutral sources detected by IASI contributing to European spring haze episode

    NASA Astrophysics Data System (ADS)

    Fortems-Cheiney, Audrey; Dufour, Gaelle; Hamaoui-Laguel, Lynda; Foret, Gilles; SIour, Guillaume; Van Damme, Martin; Meleux, Frederik; Coheur, Pierre; Clerbaux, Cathy; Clarisse, Lieven; Wallasch, Markus; Beekmann, Matthias

    2017-04-01

    Ammonia (NH3), which main source is agriculture, is an important precursor gas for particulate matter concentrations. For the first time, we derived ammonia emissions from space, using NH3 total columns from the IASI instrument onboard Metop-A, at a high resolution (grid-cell of 0.5° x 0.5°, at a daily scale), for the European spring haze episode of March 2014, 8th to 15th. During this period, IASI reveals higher NH3 emissions than in the European reference EMEP inventory over Central Europe (especially over Germany, Czech Republic and eastern France), exhibiting in addition a large day-to-day variability. This suggests emissions due to punctual spreading practices, that are difficult to anticipate with an inventory-based approach. The increase or NH3 emissions, that could reach +300% locally, leads both to an increase of NH3 and PM25 surface concentrations and conducts to a better comparison with independent measurements (in terms of bias, root mean square error and correlation). The robustness of this preliminary study is promising for future quantification of NH3 emission estimates by atmospheric inversions.

  6. The questionable contribution of the Neolithic and the Bronze Age to European craniofacial form

    PubMed Central

    Brace, C. Loring; Seguchi, Noriko; Quintyn, Conrad B.; Fox, Sherry C.; Nelson, A. Russell; Manolis, Sotiris K.; Qifeng, Pan

    2006-01-01

    Many human craniofacial dimensions are largely of neutral adaptive significance, and an analysis of their variation can serve as an indication of the extent to which any given population is genetically related to or differs from any other. When 24 craniofacial measurements of a series of human populations are used to generate neighbor-joining dendrograms, it is no surprise that all modern European groups, ranging all of the way from Scandinavia to eastern Europe and throughout the Mediterranean to the Middle East, show that they are closely related to each other. The surprise is that the Neolithic peoples of Europe and their Bronze Age successors are not closely related to the modern inhabitants, although the prehistoric/modern ties are somewhat more apparent in southern Europe. It is a further surprise that the Epipalaeolithic Natufian of Israel from whom the Neolithic realm was assumed to arise has a clear link to Sub-Saharan Africa. Basques and Canary Islanders are clearly associated with modern Europeans. When canonical variates are plotted, neither sample ties in with Cro-Magnon as was once suggested. The data treated here support the idea that the Neolithic moved out of the Near East into the circum-Mediterranean areas and Europe by a process of demic diffusion but that subsequently the in situ residents of those areas, derived from the Late Pleistocene inhabitants, absorbed both the agricultural life way and the people who had brought it. PMID:16371462

  7. Unaccounted variability in NH3 agricultural sources detected by IASI contributing to European spring haze episode

    NASA Astrophysics Data System (ADS)

    Fortems-Cheiney, A.

    2016-12-01

    Ammonia (NH3), whose main source is agriculture, is an important gaseous precursor of atmospheric particulate matter (PM). For the first time, we derived daily ammonia emissions using NH3 total columns from the Infrared Atmospheric Sounding Interferometer (IASI) onboard Metop-A, at a relatively high spatial resolution (grid-cell of 0.5° x 0.5°). During the European spring haze episode of March 2014 8th to 15th, IASI reveals NH3 total column magnitudes highlighting higher NH3 emissions over Central Europe (especially over Germany, Czech Republic and eastern France) from the ones provided by the European reference EMEP inventory (see figure). These ammonia emissions exhibit in addition a large day-to-day variability, certainly due to spreading practices. The increase of NH3 emissions derived by IASI (see NH3-SAT emissions in figure), that reaches +300% locally, leads to an increase of both NH3 and PM10 surface concentrations and allows for a better comparison with independent measurements (in terms of bias, root mean square error and correlation). This preliminary study suggest that there are good promises for i) better quantifying NH3 emissions by atmospheric inversions and ii) better forecast of spring haze episode.

  8. The GEOSS Clearinghouse based on the GeoNetwork opensource

    NASA Astrophysics Data System (ADS)

    Liu, K.; Yang, C.; Wu, H.; Huang, Q.

    2010-12-01

    The Global Earth Observation System of Systems (GEOSS) is established to support the study of the Earth system in a global community. It provides services for social management, quick response, academic research, and education. The purpose of GEOSS is to achieve comprehensive, coordinated and sustained observations of the Earth system, improve monitoring of the state of the Earth, increase understanding of Earth processes, and enhance prediction of the behavior of the Earth system. In 2009, GEO called for a competition for an official GEOSS clearinghouse to be selected as a source to consolidating catalogs for Earth observations. The Joint Center for Intelligent Spatial Computing at George Mason University worked with USGS to submit a solution based on the open-source platform - GeoNetwork. In the spring of 2010, the solution is selected as the product for GEOSS clearinghouse. The GEOSS Clearinghouse is a common search facility for the Intergovernmental Group on Ea rth Observation (GEO). By providing a list of harvesting functions in Business Logic, GEOSS clearinghouse can collect metadata from distributed catalogs including other GeoNetwork native nodes, webDAV/sitemap/WAF, catalog services for the web (CSW)2.0, GEOSS Component and Service Registry (http://geossregistries.info/), OGC Web Services (WCS, WFS, WMS and WPS), OAI Protocol for Metadata Harvesting 2.0, ArcSDE Server and Local File System. Metadata in GEOSS clearinghouse are managed in a database (MySQL, Postgresql, Oracle, or MckoiDB) and an index of the metadata is maintained through Lucene engine. Thus, EO data, services, and related resources can be discovered and accessed. It supports a variety of geospatial standards including CSW and SRU for search, FGDC and ISO metadata, and WMS related OGC standards for data access and visualization, as linked from the metadata.

  9. Divisible Atoms or None at All? Facing the European Contributions to Developments of Chemistry and Physics in China.

    PubMed

    Južnič, Stanislav

    2016-12-01

    One of the most important Mid-European professor with more than six thousand academic descendants was the leading Slovenian erudite Jurij Vega. In broader sense, Vega's and other applied sciences of the south of Holy Roman Empire of German Nationality were connected with the mercury mine of Idrija during the last half of millennia. The Idrija Mine used to be one of the two top European producers of mercury, the basic substance of atomistic alchemists. Idrija Mine contributions to the history of techniques, their examinations and approbations is comparable to the other Mid-European achievements. The peculiarities of Idrija mining environment where people valued mostly the applicative knowhow is put into the limelight. The applicative abilities of Idrija employers affected the broader surroundings including Vega's Jesuit teachers in nearby Ljubljana and the phenomena of comparatively many China-Based Jesuits connected with the area of modern Slovenia. The Jesuits' Mid-European education and networks are put into the limelight, as well as their adopted Chinese networks used for their bridging between Eastern and Western Sciences. The Western origin of the scientific-technologic-industrial revolution(s) with causes for their apparent nonexistence in Chinese frames is discussed as another Eurocentric rhetorical racist question which presumes the scientific-technologic-industrial revolution(s) as something good, positive, and therefore predominantly European. The Chinese ways into progress without those troublemaking revolutions is focused for the first time in historiography from combined scientific, moral, religious, and economic viewpoints. The Chinese contributions to particular areas of research in chemistry and physics is focused to find out the preferences and most frequent stages of (European) paradigms involved in the Chinese networks. Some predictions of future interests of Chinese chemistry and physics are provided. The Chinese Holistic Confucian distrust in

  10. CRONUS-EU Cosmic Ray Produced Nuclide Systematics - The European Contribution

    NASA Astrophysics Data System (ADS)

    Dunai, T. J.; Benedetti, L.; van der Borg, K.; von Blanckenburg, F.; Ivy-Ochs, S.; Korschinek, G.; Masarik, J.; Niedermann, S.; Pik, R.; Stuart, F.; Wieler, R.; Wijbrans, J.

    2005-12-01

    The main objective of the CRONUS-EU is to advance Terrestrial cosmogenic nuclide (TCN) techniques into a robust tool for Earth surface and environmental sciences. CRONUS-EU aims to achieve this goal via: (1) High quality calibration of TCN production rates at independently dated surfaces (2) High quality calibration of TCN production rates using artificial targets (3) Systematic cross calibration of production rates of different TCNs (4) Refinement of scaling factors that describe the spatial and temporal variation of the cosmic ray flux relevant for TCN production using calibration measurements and numerical modeling from physical principles (5) Reducing the uncertainty of decay constants (6) Establishing the use of additional mineral phases in exposure age dating (7) Improvement and standardization of chemical routines (8) Laboratory cross calibrations (9) Training of young researchers and the user community The effort necessary to achieve above goal is significant even for the strong network teams in CRONUS-EU. To strengthen our effort and to achieve international evaluation and acceptance, we are seeking close collaboration with CRONUS-Earth, the parallel-running northern American sister initiative that obtained funding through NSF. Formal links between the two initiatives are established and each consortium will address complementary aspects to achieve the common goal. CRONUS-EU is a Marie-Curie Research and Training program, supported by the European Community's Program: Improving the Human Research Potential and the Socio-economic Knowledge base. www.cronus-eu.net

  11. [Contribution of Aleksander Sapieha (1773-1812) into European galvanization therapy].

    PubMed

    Gorski, P; Goetz, W

    1996-01-01

    For the development of the therapy using electricity as agent two tracks can be identified. On the one side, the indication for applying this therapy was handled more careful, simultaneously the technical equipment was improved. The Polish noble man Alexander Sapieha (1773-1812), the leading natural scientist of the Granddukedom of Warsaw, cooperated with excellent European scientists in order to improve the galvanic battery technologically. Among these scientists were Alexander Volta (1745-1827), the inventor of the battery, and Johann Bartholomaeus Trommsdorff (1770-1837), who is considered as one of the founders of scientific pharmacy in Europe. A. Sapieha supported the publication of galvanic experiences, e.g. in the case of Alexander of Humboldt (1769-1859) by publishing his paper about electric fishes. Sapiehas connections with the scientific centers in Turin and Bologna, Erfurt, Warszaw and Paris accelerated the exchange of information about galvanism. Later the resulting mini-batteries were employed in diathermie, in defibrillators and pacemakers. Details about these connections are presented in the lecture resp. full paper.

  12. Conservation phylogeography: does historical diversity contribute to regional vulnerability in European tree frogs (Hyla arborea)?

    PubMed

    Dufresnes, Christophe; Wassef, Jérôme; Ghali, Karim; Brelsford, Alan; Stöck, Matthias; Lymberakis, Petros; Crnobrnja-Isailovic, Jelka; Perrin, Nicolas

    2013-11-01

    Documenting and preserving the genetic diversity of populations, which conditions their long-term survival, have become a major issue in conservation biology. The loss of diversity often documented in declining populations is usually assumed to result from human disturbances; however, historical biogeographic events, otherwise known to strongly impact diversity, are rarely considered in this context. We apply a multilocus phylogeographic study to investigate the late-Quaternary history of a tree frog (Hyla arborea) with declining populations in the northern and western part of its distribution range. Mitochondrial and nuclear polymorphisms reveal high genetic diversity in the Balkan Peninsula, with a spatial structure moulded by the last glaciations. While two of the main refugial lineages remained limited to the Balkans (Adriatic coast, southern Balkans), a third one expanded to recolonize Northern and Western Europe, loosing much of its diversity in the process. Our findings show that mobile and a priori homogeneous taxa may also display substructure within glacial refugia ('refugia within refugia') and emphasize the importance of the Balkans as a major European biodiversity centre. Moreover, the distribution of diversity roughly coincides with regional conservation situations, consistent with the idea that historically impoverished genetic diversity may interact with anthropogenic disturbances, and increase the vulnerability of populations. Phylogeographic models seem important to fully appreciate the risks of local declines and inform conservation strategies. © 2013 John Wiley & Sons Ltd.

  13. The europa initiative for esa's cosmic vision: a potential european contribution to nasa's Europa mission

    NASA Astrophysics Data System (ADS)

    Blanc, Michel; Jones, Geraint H.; Prieto-Ballesteros, Olga; Sterken, Veerle J.

    2016-04-01

    The assessment of the habitability of Jupiter's icy moons is considered of high priority in the roadmaps of the main space agencies, including the decadal survey and esa's cosmic vision plan. the voyager and galileo missions indicated that europa and ganymede may meet the requirements of habitability, including deep liquid aqueous reservoirs in their interiors. indeed, they constitute different end-terms of ocean worlds, which deserve further characterization in the next decade. esa and nasa are now both planning to explore these ice moons through exciting and ambitious missions. esa selected in 2012 the juice mission mainly focused on ganymede and the jupiter system, while nasa is currently studying and implementing the europa mission. in 2015, nasa invited esa to provide a junior spacecraft to be carried on board its europa mission, opening a collaboration scheme similar to the very successful cassini-huygens approach. in order to define the best contribution that can be made to nasa's europa mission, a europa initiative has emerged in europe. its objective is to elaborate a community-based strategy for the proposition of the best possible esa contribution(s) to nasa's europa mission, as a candidate for the upcoming selection of esa's 5th medium-class mission . the science returns of the different potential contributions are analysed by six international working groups covering complementary science themes: a) magnetospheric interactions; b) exosphere, including neutrals, dust and plumes; c) geochemistry; d) geology, including expressions of exchanges between layers; e) geophysics, including characterization of liquid water distribution; f) astrobiology. each group is considering different spacecraft options in the contexts of their main scientific merits and limitations, their technical feasibility, and of their interest for the development of esa-nasa collaborations. there are five options under consideration: (1) an augmented payload to the europa mission main

  14. The contribution of nitrogen deposition to the eutrophication signal in understorey plant communities of European forests.

    PubMed

    van Dobben, Han F; de Vries, Wim

    2017-01-01

    We evaluated effects of atmospheric deposition of nitrogen on the composition of forest understorey vegetation both in space and time, using repeated data from the European wide monitoring program ICP-Forests, which focuses on normally managed forest. Our aim was to assess whether both spatial and temporal effects of deposition can be detected by a multiple regression approach using data from managed forests over a relatively short time interval, in which changes in the tree layer are limited. To characterize the vegetation, we used indicators derived from cover percentages per species using multivariate statistics and indicators derived from the presence/absence, that is, species numbers and Ellenberg's indicator values. As explanatory variables, we used climate, altitude, tree species, stand age, and soil chemistry, besides deposition of nitrate, ammonia and sulfate. We analyzed the effects of abiotic conditions at a single point in time by canonical correspondence analysis and multiple regression. The relation between the change in vegetation and abiotic conditions was analyzed using redundancy analysis and multiple regression, for a subset of the plots that had both abiotic data and enough species to compute a mean Ellenberg N value per plot using a minimum of three species. Results showed that the spatial variation in the vegetation is mainly due to "traditional" factors such as soil type and climate, but a statistically significant part of the variation could be ascribed to atmospheric deposition of nitrate. The change in the vegetation over the past c. 10 years was also significantly correlated to nitrate deposition. Although the effect of deposition on the individual species could not be clearly defined, the effect on the vegetation as a whole was a shift toward nitrophytic species as witnessed by an increase in mean Ellenberg's indicator value.

  15. The contribution of the Volcano Observations Work Package to the implementation of the European Plate Observing System

    NASA Astrophysics Data System (ADS)

    Puglisi, Giuseppe

    2016-04-01

    The overall aim of the implementation phase of European Plate Observing System (EPOS) is to make the integrated platform operational in order to guarantee seamless access to the data provided by the European Solid Earth communities. The Volcano Observations Work Package (WP11) contributes to this objective by implementing a Thematic Core Service (TCS) which is planned to give access to the data and services provided by the European Volcano Observatories (VO) and some Volcanological Research Institutions (VRI; such as university departments, laboratories, etc.). Both types are considered as national research infrastructures (RI) which the TCS will integrate. Currently, monitoring networks on European volcanoes consist of thousands of stations or sites where volcanological parameters are continuously or periodically measured. These sites are equipped with instruments for geophysical (seismic, geodetic, gravimetric, electromagnetic), geochemical (volcanic plumes, fumaroles, groundwater, rivers, soils), environmental observations (e.g. meteorological and air quality parameters), as well as various prototypal monitoring systems (e.g. Doppler radars, ground based SAR). Across Europe several laboratories provide sample characterization (rocks, gases, isotopes, etc.), quasi-continuous analysis of space-borne data (SAR, thermal imagery, SO2 and ash), as well as high-performance computing facilities. All these RIs provide high-quality information (observations) on the current status of European volcanoes and the geodynamic background of the surrounding areas. The implementation of the Volcano Observations TCS will address technical as well as managerial issues, both considering the current heterogeneous state-of-the-art of the volcanological research infrastructures in Europe. Indeed, the current arrangement of individual VO and VRI is considered too fragmented to be considered as a unique distributed infrastructure. Therefore, the main effort in the framework of the EPOS

  16. Making Progress and Gaining Momentum in Global 3Rs Efforts: How the European Pharmaceutical Industry Is Contributing

    PubMed Central

    Fleetwood, Gill; Chlebus, Magda; Coenen, Joachim; Dudoignon, Nicolas; Lecerf, Catherine; Maisonneuve, Catherine; Robinson, Sally

    2015-01-01

    Animal research together with other investigational methods (computer modeling, in vitro tests, etc) remains an indispensable part of the pharmaceutical research and development process. The European pharmaceutical industry recognizes the responsibilities inherent in animal research and is committed to applying and enhancing 3Rs principles. New nonsentient, ex vivo, and in vitro methods are developed every day and contribute to reducing and, in some instances, replacing in vivo studies. Their utility is however limited by the extent of our current knowledge and understanding of complex biological systems. Until validated alternative ways to model these complex interactions become available, animals remain indispensable in research and safety testing. In the interim, scientists continue to look for ways to reduce the number of animals needed to obtain valid results, refine experimental techniques to enhance animal welfare, and replace animals with other research methods whenever feasible. As research goals foster increasing cross-sector and international collaboration, momentum is growing to enhance and coordinate scientific innovation globally—beyond a single company, stakeholder group, sector, region, or country. The implementation of 3Rs strategies can be viewed as an integral part of this continuously evolving science, demonstrating the link between science and welfare, benefiting both the development of new medicines and animal welfare. This goal is one of the key objectives of the Research and Animal Welfare working group of the European Federation of Pharmaceutical Industries and Associations. PMID:25836966

  17. The Contribution of The University of Padova To Central European Geodesy

    NASA Astrophysics Data System (ADS)

    Caporali, A.

    The definition and maintenance of a geodetic reference system by modern techniques requires systematic temporal changes of the position of the defining stations to be taken into account. Most of these drifts are accommodated by present day plate tec- tonics. If the lithospheric plate to which a given station belongs were perfectly rigid, then a simple plate model based upon rigid rotations about Eulerian poles would suf- fice to predict the horizontal coordinates of each station at any epoch, once the coor- dinates of that station are known at a reference epoch. In Europe, there are stations well located inside old, stable areas which may be considered rigid, but other sta- tions are at or near continental margins undergoing active deformation, or are within a relatively recent portion of a tectonic unit subject to intraplate stress or volcanism. Velocities of stations in the most recent ITRF solutions do, in fact, exhibit in some cases departures from the NUVEL1A NNR plate model in Europe and elsewhere, but the reasons for these discrepancies are not always well understood. For example, if a particular station of the network exhibits a velocity anomaly relative to a reference velocity model, then it is of interest to understand the reasons for the anomaly, and its spatial extent, that is if it is local to that station, or if nearby stations are also affected, and with which tapering as a function of distance. As part of the research activities in support of the CEI/CERGOP and EUREF, the time series of coordinates of European Permanent Network (EPN) stations in the Alpine U Mediterranean U Dinarides region are examined both in the time and space domains, and hypotheses are formulated on the reasons of systematic departures from linearity. The time domain analysis con- sists in the construction of the Power Spectral Density and autocorrelation function of the time series of each coordinate for each station, the assessment of the type(s) of noise and periodicities

  18. The Contribution of the University of Padova to Central European Geodesy

    NASA Astrophysics Data System (ADS)

    Caporali, A.

    2003-04-01

    The definition and maintenance of a geodetic reference system by modern techniques requires systematic temporal changes of the position of the defining stations to be taken into account. Most of these drifts are accommodated by present day plate tectonics. If the lithospheric plate to which a given station belongs were perfectly rigid, then a simple plate model based upon rigid rotations about Eulerian poles would suffice to predict the horizontal coordinates of each station at any epoch, once the coordinates of that station are known at a reference epoch. In Europe, there are stations well located inside old, stable areas which may be considered rigid, but other stations are at or near continental margins undergoing active deformation, or are within a relatively recent portion of a tectonic unit subject to intraplate stress or volcanism. Velocities of stations in the most recent ITRF solutions do, in fact, exhibit in some cases departures from the NUVEL1A NNR plate model in Europe and elsewhere, but the reasons for these discrepancies are not always well understood. For example, if a particular station of the network exhibits a velocity anomaly relative to a reference velocity model, then it is of interest to understand the reasons for the anomaly, and its spatial extent, that is if it is local to that station, or if nearby stations are also affected, and with which tapering as a function of distance. As part of the research activities in support of the CEI/CERGOP and EUREF, the time series of coordinates of European Permanent Network (EPN) stations in the Alpine Mediterranean Dinarides region are examined both in the time and space domains, and hypotheses are formulated on the reasons of systematic departures from linearity. The time domain analysis consists in the construction of the Power Spectral Density and autocorrelation function of the time series of each coordinate for each station, the assessment of the type(s) of noise and periodicities, and an estimate

  19. [Spanish contribution to the creation of a European analytical database of trans-fatty acids].

    PubMed

    Cuadrado, C; Carbajal, A; Núñez, C; Ruiz-Roso, B; Moreiras, O

    1998-01-01

    Within the AAIR Program of the EU titled Evaluation of the Ingestion of Trans Fatty Acids (FA) and its association with cardiovascular risk factors in European countries (TRANSFAIR), which is being carried out in 16 countries with different alimentary habits, among which is our country, we have developed the following study. Based on the information derived from the last National Nutrition and Feeding Study (ENNA-3), we have made up a list of foods which make up 95% of the total ingestion of lipids, and it also includes those which although they are not included within this percentage, may have an especially high trans isomer content as a result of their processing. The foods selected for the analysis belong to different food groups: cereals, milk products, oils and fats, meats, various, and pre-cooked foods, until making up a total of 100 foods for each country. The central analysis laboratory is that of the Department of Human Nutrition, TNO Nutrition and Food Research, Zeist (The Netherlands). In each sample, in addition to the total lipids, one determines the saturated and unsaturated fatty acids, including the cis and trans isomers. The trans FA's measured were: C14:1 T9, C16:1 T9, C18:1 T, C18:2 T, C18:3 T + C20:1 T, C20:2 T11,14, and C22:1 T13. Of the samples analyzed, the highest percentages of trans FA with respect to the total FA corresponded to the following foods: French fries, pre-cooked and frozen croquettes sliced bread, margarine, cakes, and frozen mille feuilles dough of different industrial brands. The lowest percentages of trans FA's were found in refined vegetable oils (sunflower and olive), those used for deep frying, and those discarded in catering, as well as in some commercial brands of cookies and ice creams. Pure chocolate, different brands of sweetened powdered cocoa, and ready to make chocolate, did not contain and trans FA.

  20. Patient representatives' contributions to the benefit-risk assessment tasks of the European Medicines Agency scientific committees.

    PubMed

    Bernabe, Rosemarie D L C; van Thiel, Ghislaine J M W; van Delden, Johannes

    2014-12-01

    In the European Medicines Agency (EMA), the involvement of patients has been increasingly recognized as valuable and necessary. Specifically in scientific committees, patients through patient representatives are actively involved in deliberations and decision making processes. These scientific committees are meant to ensure that licensed medicines have a positive benefit-risk ratio in favour of the patients and users. To investigate what the contributions are of patient representatives in benefit-risk assessment, we interviewed 15 scientific committee members, 10 of whom are/were EU-state regulatory representatives and five are/were patient representatives. We asked the participants questions related to the benefit-risk assessment tasks of their committees, the connection between patient representatives and the patient perspective, and the contribution of patient representatives in the various benefit-risk assessments tasks. We found that the contribution of patient representatives benefit-risk assessment may be a variable of the benefits and the risks involved in the drug such that the necessity of their contribution is strongly felt when both benefits and risks are high, when benefits are almost equal or are equal to risks and when both benefits and risks are low. In terms of the various benefit-risk tasks, patient representatives contribute to benefit-risk analysis by providing criteria that help define the benefit-risk picture. In benefit-risk evaluation, patient representatives aid in providing a specific basis for the values and weights given to specific benefits and risks and in decision making, they provide what may be a crucial patient perspective in terms of the acceptability of risks. Hence, patient representatives provide a specific expertise in these scientific committees. © 2014 The British Pharmacological Society.

  1. National water-information clearinghouse activities; ground-water perspective

    USGS Publications Warehouse

    Haupt, C.A.; Jensen, R.A.

    1988-01-01

    The US Geological Survey (USGS) has functioned for many years as an informal clearinghouse for water resources information, enabling users to access groundwater information effectively. Water resources clearinghouse activities of the USGS are conducted through several separate computerized water information programs that are involved in the collection, storage, retrieval, and distribution of different types of water information. The following USGS programs perform water information clearinghouse functions and provide the framework for a formalized National Water-Information Clearinghouse: (1) The National Water Data Exchange--a nationwide confederation of more than 300 Federal, State, local, government, academic, and private water-oriented organizations that work together to improve access to water data; (2) the Water Resources Scientific Information Center--acquires, abstracts, and indexes the major water-resources-related literature of the world, and provides this information to the water resources community; (3) the Information Transfer Program--develops innovative approaches to transfer information and technology developed within the USGS to audiences in the public and private sectors; (4) the Hydrologic Information Unit--provides responses to a variety of requests, both technical and lay-oriented, for water resources information , and helps efforts to conduct water resources research; (5) the Water Data Storage and Retrieval System--maintains accessible computerized files of hydrologic data collected nationwide, by the USGS and other governmental agencies, from stream gaging stations, groundwater observation wells, and surface- and groundwater quality sampling sites; (6) the Office of Water Data Coordination--coordinate the water data acquisition activities of all agencies of the Federal Government, and is responsible for the planning, design, and inter-agency coordination of a national water data and information network; and (7) the Water Resources Research

  2. California Earthquake Clearinghouse Activation for August 24, 2014, M6.0 South Napa Earthquake

    NASA Astrophysics Data System (ADS)

    Rosinski, A.; Parrish, J.; Mccrink, T. P.; Tremayne, H.; Ortiz, M.; Greene, M.; Berger, J.; Blair, J. L.; Johnson, M.; Miller, K.; Seigel, J.; Long, K.; Turner, F.

    2014-12-01

    The Clearinghouse's principal functions are to 1) coordinate field investigations of earth scientists, engineers, and other participating researchers; 2) facilitate sharing of observations through regular meetings and through the Clearinghouse website; and 3) notify disaster responders of crucial observations or results. Shortly after 3:20 a.m., on August 24, 2014, Clearinghouse management committee organizations, the California Geological Survey (CGS), the Earthquake Engineering Research Institute (EERI), the United States Geological Survey (USGS), the California Office of Emergency Services (CalOES), and the California Seismic Safety Commission (CSSC), authorized activation of a virtual Clearinghouse and a physical Clearinghouse location. The California Geological Survey, which serves as the permanent, lead coordination organization for the Clearinghouse, provided all coordination with the state for all resources required for Clearinghouse activation. The Clearinghouse physical location, including mobile satellite communications truck, was opened at a Caltrans maintenance facility located at 3161 Jefferson Street, in Napa. This location remained active through August 26, 2014, during which time it drew the participation of over 100 experts from more than 40 different organizations, and over 1730 remote visitors via the Virtual Clearinghouse and online data compilation map. The Clearinghouse conducted three briefing calls each day with the State Operations Center (SOC) and Clearinghouse partners, and also conducted nightly briefings, accessible to remote participants via webex, with field personnel. Data collected by field researchers was compiled into a map through the efforts of EERI and USGS volunteers in the Napa Clearinghouse. EERI personnel continued to provide updates to the compilation map over an extended period of time following de-activation of the Clearinghouse. In addition, EERI managed the Clearinghouse website. Two overflights were conducted, for

  3. Springtime Arctic haze contributions of submicron organic particles from European and Asian combustion sources

    NASA Astrophysics Data System (ADS)

    Frossard, Amanda A.; Shaw, Patrick M.; Russell, Lynn M.; Kroll, Jesse H.; Canagaratna, Manjula R.; Worsnop, Douglas R.; Quinn, Patricia K.; Bates, Timothy S.

    2011-03-01

    The composition of Arctic aerosol, especially during the springtime Arctic haze, may play an important role in the radiative balance of the Arctic. The contribution of organic components to Arctic haze has only recently been investigated. Because measurements in this region are sparse, little is known about organic particle composition, sources, and concentrations. This study compares springtime measurements in the Arctic regions north of the Atlantic (ICEALOT, 2008) and Pacific (Barrow, Alaska, 2008 and 2009) oceans. The aerosol organic functional group composition from Fourier transform infrared (FTIR) spectroscopy combined with positive matrix factorization (PMF) and elemental tracer analysis indicate that mixed combustion sources account for more than 60% (>0.3 μg m-3) of the submicron organic mass (OM1) for springtime haze conditions in both regions. Correlations with typical combustion tracers (S, Zn, K, Br, V) provide evidence for the contribution of combustion sources to the Arctic OM1. However, the two regions are influenced by different urban and industrial centers with different fuel usage. High-sulfur coal burning in northeastern Europe impacts the northern Atlantic Arctic region, while oil burning and forest fires in northeastern Asia and Alaska impact the northern Pacific Arctic region. Quadrupole and High Resolution Aerosol Mass Spectrometry measurements confirm the highly oxygenated nature of the OM1, with an oxygenated organic aerosol (OOA) spectrum from PMF. High co-emissions of sulfate and organics from coal-burning in northeastern Europe produce significant concentrations of organosulfate functional groups that account for 10% of OM1 measured by FTIR spectroscopy during ICEALOT. These observations provide preliminary support for a heterogeneous mechanism of organosulfate formation on acidic sulfate particles.

  4. Milutin Milanković (1879-1958) and his Contribution to the European Astronomy

    NASA Astrophysics Data System (ADS)

    Dimitrijević, Milan S.

    Milutin Milanković (Dalj, May 28, 1879 - Belgrade, December 12, 1958), former director of the Belgrade Astronomical observatory and vice president of the Serbian Academy of Sciences and Arts, is the most distinguished Serbian astronomer of the XX century. In honour to his scientific achievements in astronomy a crater on the far side of the Moon (coordinates +170o, +77o) was given his name at the 14th IAU General Assembly in Brighton in 1970. His name is given also to a crater on Mars (coordinates +147o, +55o) at the 15th IAU General Assembly in Sidney in 1973. In 1982 a small planet, provisorily designated 1936 GA, discovered in 1930 by M. Protić and P. Djurković, received its permanent name: 1605 Milanković. Milutin Milanković went down in the history of science as the man who explained the phenomenon of the Ice Ages by slow changes of the Earth insolation in consequence of changes of the Earth's axis inclination and of those of the parameters of the Earth's motion round the Sun. Milanković elucidated also the history of the Earth's climate as well as that of other planets, being in addition the author of the mathematical theory of climate and of the Earth's pole motion. His scientific results, life and activities will be discussed in this contribution.

  5. European and Mediterranean mercury modelling: Local and long-range contributions to the deposition flux

    NASA Astrophysics Data System (ADS)

    Gencarelli, Christian N.; De Simone, Francesco; Hedgecock, Ian M.; Sprovieri, Francesca; Yang, Xin; Pirrone, Nicola

    2015-09-01

    Mercury (Hg) is a global pollutant that is known to have adverse effects on human health, and most human exposure to toxic methylmercury is through fish consumption. Soluble Hg compounds in the marine environment can be methylated in the water column and enter the base of the food chain. Atmospheric deposition is the most important pathway by which Hg enters marine ecosystems. The atmospheric chemistry of Hg has been simulated over Europe and the Mediterranean for the year 2009, using the WRF/Chem model and employing two different gas phase Hg oxidation mechanisms. The contributions to the marine deposition flux from dry deposition, synoptic scale wet deposition and convective wet deposition have been determined. The Hg deposition fluxes resulting from transcontinental transport and local/regional emission sources has been determined using both Br/BrO and O3/OH atmospheric oxidation mechanisms. The two mechanisms give significantly different annual deposition fluxes (129 Mg and 266 Mg respectively) over the modelling domain. Dry deposition is more significant using the O3/OH mechanism, while proportionally convective wet deposition is enhanced using the Br/BrO mechanism. The simulations using the Br/BrO oxidation compared best with observed Hg fluxes in precipitation. Local/regional Hg emissions have the most impact within the model domain during the summer. A comparison of simulations using the 2005 and 2010 AMAP/UNEP Hg emission inventories show that although there is a decrease of 33% in anthropogenic emissions between the two reference years, the total simulated deposition in the regions diminishes by only 12%. Simulations using the 2010 inventory reproduce observations somewhat better than those using the 2005 inventory for 2009.

  6. 45 CFR 2518.100 - What is the purpose of a Service-Learning Clearinghouse?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false What is the purpose of a Service-Learning...) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SERVICE-LEARNING CLEARINGHOUSE § 2518.100 What is the purpose of a Service-Learning Clearinghouse? The Corporation will provide financial assistance, from...

  7. 45 CFR 2518.100 - What is the purpose of a Service-Learning Clearinghouse?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false What is the purpose of a Service-Learning...) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SERVICE-LEARNING CLEARINGHOUSE § 2518.100 What is the purpose of a Service-Learning Clearinghouse? The Corporation will provide financial assistance, from...

  8. 45 CFR 2518.100 - What is the purpose of a Service-Learning Clearinghouse?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false What is the purpose of a Service-Learning...) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SERVICE-LEARNING CLEARINGHOUSE § 2518.100 What is the purpose of a Service-Learning Clearinghouse? The Corporation will provide financial assistance, from...

  9. 45 CFR 2518.100 - What is the purpose of a Service-Learning Clearinghouse?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false What is the purpose of a Service-Learning...) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SERVICE-LEARNING CLEARINGHOUSE § 2518.100 What is the purpose of a Service-Learning Clearinghouse? The Corporation will provide financial assistance, from...

  10. 45 CFR 2518.100 - What is the purpose of a Service-Learning Clearinghouse?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false What is the purpose of a Service-Learning...) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SERVICE-LEARNING CLEARINGHOUSE § 2518.100 What is the purpose of a Service-Learning Clearinghouse? The Corporation will provide financial assistance, from...

  11. Procedures and Standards Handbook. Version 3.0. What Works Clearinghouse

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2014

    2014-01-01

    This "What Works Clearinghouse Procedures and Standards Handbook (Version 3.0)" provides a detailed description of the standards and procedures of the What Works Clearinghouse (WWC). The remaining chapters of this Handbook are organized to take the reader through the basic steps that the WWC uses to develop a review protocol, identify…

  12. Oregon Intellectual Freedom Clearinghouse: Fourth Annual Report. July 1, 1990-June 30, 1991.

    ERIC Educational Resources Information Center

    Oregon State Library, Salem. Library Development Services.

    This report on the activities of the Oregon Intellectual Freedom Clearinghouse during the time period between July 1, 1990, and June 30, 1991, begins with a summary of data on challenges against library materials reported to the clearinghouse during this time period. Details about each challenge reported by public libraries and school library…

  13. Oregon Intellectual Freedom Clearinghouse Annual Report. May 1987-June 30, 1988.

    ERIC Educational Resources Information Center

    Oregon State Library, Salem. Intellectual Freedom Clearinghouse.

    Established in May 1987 by the Oregon State Library to serve as a central clearinghouse for the collection of reports about challenges against library materials, the Oregon Intellectual Freedom Clearinghouse received a total of 17 formal challenges against library materials during its first year of operation. Of these, 10 challenges were received…

  14. ERIC Clearinghouse Scope of Interest Guide. ERIC Processing Manual, Appendix A.

    ERIC Educational Resources Information Center

    Brandhorst, Ted, Ed.; And Others

    This guide identifies and describes the subject areas covered by the ERIC Clearinghouses. Each Clearinghouse scope statement is provided in the following three-part format: (1) Formal Statement--A comprehensive and detailed description of the scope areas, mainly for use by the ERIC Facility in assigning documents (on the basis of their subject…

  15. Procedures and Standards Handbook. Version 3.0. What Works Clearinghouse

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2014

    2014-01-01

    This "What Works Clearinghouse Procedures and Standards Handbook (Version 3.0)" provides a detailed description of the standards and procedures of the What Works Clearinghouse (WWC). The remaining chapters of this Handbook are organized to take the reader through the basic steps that the WWC uses to develop a review protocol, identify…

  16. 77 FR 48506 - Notice of Submission for OMB Review; Institute of Education Sciences; What Works Clearinghouse

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... households. Information from the submissions will be used to further the work of the WWC in reviewing studies... Notice of Submission for OMB Review; Institute of Education Sciences; What Works Clearinghouse AGENCY... approved collection under OMB Control Number 1850-0788 for the What Works Clearinghouse (WWC) . The...

  17. The European Long-range Research Initiative (LRI): A decade of contributions to human health protection, exposure modelling and environmental integrity.

    PubMed

    de Boer, Jacob; Fritsche, Ellen; Schoeters, Greet; Kimber, Ian

    2015-11-04

    The European Long-range Research Initiative (LRI) was launched in 2000. The objective of this programme is to provide increased understanding of the potential impact of chemicals on human health and the environment. The aim has been to reduce uncertainty associated with innovation, and to promote evidence-based decision making. In pursuing these objectives the LRI has commissioned independent scientific research in institutions throughout Europe and beyond. The portfolio of research supported by the LRI has delivered significant contributions to risk assessment sciences. In addition, the LRI programme has benefited the broader scientific community. In this review article members of the Cefic European Scientific Advisory Panel (ESAP), the body charged with providing oversight of the LRI programme, illustrate some of those achievements by reference to specific areas of research (respiratory allergy, human biomonitoring, environment and wildlife), and also the contribution made to the development of European scientists through the annual LRI Award Programme.

  18. Contributions to Innovative Learning and Teaching? Effective Research-Based Pedagogy--A Response to TLRP's Principles from a European Perspective

    ERIC Educational Resources Information Center

    Dochy, Filip; Berghmans, Inneke; Kyndt, Eva; Baeten, Marlies

    2011-01-01

    Starting from the contribution on the "ten principles of effective pedagogy" by James and Pollard, we critically reflect on some of the principles and assess whether these principles can be grounded in the wider European research literature that has accumulated internationally. We conclude that these principles can be supported and…

  19. Contributions to Innovative Learning and Teaching? Effective Research-Based Pedagogy--A Response to TLRP's Principles from a European Perspective

    ERIC Educational Resources Information Center

    Dochy, Filip; Berghmans, Inneke; Kyndt, Eva; Baeten, Marlies

    2011-01-01

    Starting from the contribution on the "ten principles of effective pedagogy" by James and Pollard, we critically reflect on some of the principles and assess whether these principles can be grounded in the wider European research literature that has accumulated internationally. We conclude that these principles can be supported and…

  20. Classification of adults suffering from typical gastroesophageal reflux disease symptoms: contribution of latent class analysis in a European observational study.

    PubMed

    Bruley des Varannes, Stanislas; Cestari, Renzo; Usova, Liudmila; Triantafyllou, Konstantinos; Alvarez Sanchez, Angel; Keim, Sofia; Bergmans, Paul; Marelli, Silvia; Grahl, Esther; Ducrotté, Philippe

    2014-06-26

    As illustrated by the Montreal classification, gastroesophageal reflux disease (GERD) is much more than heartburn and patients constitute a heterogeneous group. Understanding if links exist between patients' characteristics and GERD symptoms, and classify subjects based on symptom-profile could help to better understand, diagnose, and treat GERD. The aim of this study was to identify distinct classes of GERD patients according to symptom profiles, using a specific statistical tool: Latent class analysis. An observational single-visit study was conducted in 5 European countries in 7700 adults with typical symptoms. A latent class analysis was performed to identify "latent classes" and was applied to 12 indicator symptoms. On 7434 subjects with non-missing indicators, latent class analysis yielded 5 latent classes. Class 1 grouped the highest severity of typical GERD symptoms during day and night, more digestive and non-digestive GERD symptoms, and bad sleep quality. Class 3 represented less frequent and less severe digestive and non-digestive GERD symptoms, and better sleep quality than in class 1. In class 2, only typical GERD symptoms at night occurred. Classes 4 and 5 represented daytime and nighttime regurgitation. In class 4, heartburn was also identified and more atypical digestive symptoms. Multinomial logistic regression showed that country, age, sex, smoking, alcohol use, low-fat diet, waist circumference, recent weight gain (>5 kg), elevated triglycerides, metabolic syndrome, and medical GERD treatment had a significant effect on latent classes. Latent class analysis classified GERD patients based on symptom profiles which related to patients' characteristics. Although further studies considering these proposed classes have to be conducted to determine the reproducibility of this classification, this new tool might contribute in better management and follow-up of patients with GERD.

  1. Contribution of 32 GWAS-Identified Common Variants to Severe Obesity in European Adults Referred for Bariatric Surgery

    PubMed Central

    Yousseif, Ahmed; Pucci, Andrea; Santini, Ferruccio; Karra, Efthimia; Querci, Giorgia; Pelosini, Caterina; McCarthy, Mark I.; Lindgren, Cecilia M.; Batterham, Rachel L.

    2013-01-01

    The prevalence of severe obesity, defined as body mass index (BMI) ≥35.0 kg/m2, is rising rapidly. Given the disproportionately high health burden and healthcare costs associated with this condition, understanding the underlying aetiology, including predisposing genetic factors, is a biomedical research priority. Previous studies have suggested that severe obesity represents an extreme tail of the population BMI variation, reflecting shared genetic factors operating across the spectrum. Here, we sought to determine whether a panel of 32 known common obesity-susceptibility variants contribute to severe obesity in patients (n = 1,003, mean BMI 48.4±8.1 kg/m2) attending bariatric surgery clinics in two European centres. We examined the effects of these 32 common variants on obesity risk and BMI, both as individual markers and in combination as a genetic risk score, in a comparison with normal-weight controls (n = 1,809, BMI 18.0–24.9 kg/m2); an approach which, to our knowledge, has not been previously undertaken in the setting of a bariatric clinic. We found strong associations with severe obesity for SNP rs9939609 within the FTO gene (P = 9.3×10−8) and SNP rs2815752 near the NEGR1 gene (P = 3.6×10−4), and directionally consistent nominal associations (P<0.05) for 12 other SNPs. The genetic risk score associated with severe obesity (P = 8.3×10−11) but, within the bariatric cohort, this score did not associate with BMI itself (P = 0.264). Our results show significant effects of individual BMI-associated common variants within a relatively small sample size of bariatric patients. Furthermore, the burden of such low-penetrant risk alleles contributes to severe obesity in this population. Our findings support that severe obesity observed in bariatric patients represents an extreme tail of the population BMI variation. Moreover, future genetic studies focused on bariatric patients may provide valuable insights into the pathogenesis of

  2. Factors Contributing to 50-ft Walking Speed and Observed Ethnic Differences in Older Community-Dwelling Mexican Americans and European Americans

    PubMed Central

    Hazuda, Helen P.

    2015-01-01

    Background Mexican Americans comprise the most rapidly growing segment of the older US population and are reported to have poorer functional health than European Americans, but few studies have examined factors contributing to ethnic differences in walking speed between Mexican Americans and European Americans. Objective The purpose of this study was to examine factors that contribute to walking speed and observed ethnic differences in walking speed in older Mexican Americans and European Americans using the disablement process model (DPM) as a guide. Design This was an observational, cross-sectional study. Methods Participants were 703 Mexican American and European American older adults (aged 65 years and older) who completed the baseline examination of the San Antonio Longitudinal Study of Aging (SALSA). Hierarchical regression models were performed to identify the contribution of contextual, lifestyle/anthropometric, disease, and impairment variables to walking speed and to ethnic differences in walking speed. Results The ethic difference in unadjusted mean walking speed (Mexican Americans=1.17 m/s, European Americans=1.29 m/s) was fully explained by adjustment for contextual (ie, age, sex, education, income) and lifestyle/anthropometric (ie, body mass index, height, physical activity) variables; adjusted mean walking speed in both ethnic groups was 1.23 m/s. Contextual variables explained 20.3% of the variance in walking speed, and lifestyle/anthropometric variables explained an additional 8.4%. Diseases (ie, diabetes, stroke, chronic obstructive pulmonary disease) explained an additional 1.9% of the variance in walking speed; impairments (ie, FEV1, upper leg pain, and lower extremity strength and range of motion) contributed an additional 5.5%. Thus, both nonmodifiable (ie, contextual, height) and modifiable (ie, impairments, body mass index, physical activity) factors contributed to walking speed in older Mexican Americans and European Americans. Limitations

  3. Factors Contributing to 50-ft Walking Speed and Observed Ethnic Differences in Older Community-Dwelling Mexican Americans and European Americans.

    PubMed

    Quiben, Myla U; Hazuda, Helen P

    2015-06-01

    Mexican Americans comprise the most rapidly growing segment of the older US population and are reported to have poorer functional health than European Americans, but few studies have examined factors contributing to ethnic differences in walking speed between Mexican Americans and European Americans. The purpose of this study was to examine factors that contribute to walking speed and observed ethnic differences in walking speed in older Mexican Americans and European Americans using the disablement process model (DPM) as a guide. This was an observational, cross-sectional study. Participants were 703 Mexican American and European American older adults (aged 65 years and older) who completed the baseline examination of the San Antonio Longitudinal Study of Aging (SALSA). Hierarchical regression models were performed to identify the contribution of contextual, lifestyle/anthropometric, disease, and impairment variables to walking speed and to ethnic differences in walking speed. The ethic difference in unadjusted mean walking speed (Mexican Americans=1.17 m/s, European Americans=1.29 m/s) was fully explained by adjustment for contextual (ie, age, sex, education, income) and lifestyle/anthropometric (ie, body mass index, height, physical activity) variables; adjusted mean walking speed in both ethnic groups was 1.23 m/s. Contextual variables explained 20.3% of the variance in walking speed, and lifestyle/anthropometric variables explained an additional 8.4%. Diseases (ie, diabetes, stroke, chronic obstructive pulmonary disease) explained an additional 1.9% of the variance in walking speed; impairments (ie, FEV1, upper leg pain, and lower extremity strength and range of motion) contributed an additional 5.5%. Thus, both nonmodifiable (ie, contextual, height) and modifiable (ie, impairments, body mass index, physical activity) factors contributed to walking speed in older Mexican Americans and European Americans. The study was conducted in a single geographic area and

  4. Introgression and isolation contributed to the development of Hungarian Mangalica pigs from a particular European ancient bloodline

    PubMed Central

    2013-01-01

    Background Mangalica breeds are indigenous to Hungary and their breeding history dates back to about 200–250 years ago. They are fat-type pigs and have a rare curly hair phenotype. The aim of our study was to establish the relationships between these unique breeds and other European breeds. Results Based on a core sequence of 382 bp present in 2713 mitochondrial D-loop sequences from pigs belonging to 38 local breeds from nine countries, five cosmopolitan breeds and wild boars from 14 countries, we identified 164 haplotypes. More than half of the 2713 sequences belonged to either four haplotypes characteristic of continental European breeds or two haplotypes characteristic of British/cosmopolitan breeds; each haplotype is present in more than 100 individuals. Most Mangalica individuals belonged either to one of these common continental European haplotypes or to two Mangalica-specific haplotypes that were absent in all other breeds. In addition, we identified the ancestral mitochondrial D-loop signature present in these 2713 sequences and found that ~ 80% carried the European ancient signatures, ANC-Aside and ANC-Cside or their closely related signatures, while most of the remaining sequences carried a modern Asian signature, ANC-Easia. Mangalica individuals carried the ANC-Aside signature, but not the ANC-Cside or ANC-Easia signatures. Conclusions In all the Mangalica individuals, a unique ancient European signature was found in the mitochondrial DNA D-loop region, but they belonged almost exclusively to either certain very abundant European or two Mangalica-specific D-loop haplotypes. This indicates that the present-day Mangalica population in Hungary evolved either by introgression of other European breeds and wild boars or via total isolation after the divergence of European ancient porcine bloodlines. PMID:23815680

  5. The Contribution of National Disparities to International Differences in Mortality Between the United States and 7 European Countries

    PubMed Central

    Avendano, Mauricio; Berkman, Lisa F.; Bopp, Matthias; Deboosere, Patrick; Lundberg, Olle; Martikainen, Pekka; Menvielle, Gwenn; van Lenthe, Frank J.; Mackenbach, Johan P.

    2015-01-01

    Objectives. This study examined to what extent the higher mortality in the United States compared to many European countries is explained by larger social disparities within the United States. We estimated the expected US mortality if educational disparities in the United States were similar to those in 7 European countries. Methods. Poisson models were used to quantify the association between education and mortality for men and women aged 30 to 74 years in the United States, Belgium, Denmark, Finland, France, Norway, Sweden, and Switzerland for the period 1989 to 2003. US data came from the National Health Interview Survey linked to the National Death Index and the European data came from censuses linked to national mortality registries. Results. If people in the United States had the same distribution of education as their European counterparts, the US mortality disadvantage would be larger. However, if educational disparities in mortality within the United States equaled those within Europe, mortality differences between the United States and Europe would be reduced by 20% to 100%. Conclusions. Larger educational disparities in mortality in the United States than in Europe partly explain why US adults have higher mortality than their European counterparts. Policies to reduce mortality among the lower educated will be necessary to bridge the mortality gap between the United States and European countries. PMID:25713947

  6. The contribution of national disparities to international differences in mortality between the United States and 7 European countries.

    PubMed

    van Hedel, Karen; Avendano, Mauricio; Berkman, Lisa F; Bopp, Matthias; Deboosere, Patrick; Lundberg, Olle; Martikainen, Pekka; Menvielle, Gwenn; van Lenthe, Frank J; Mackenbach, Johan P

    2015-04-01

    This study examined to what extent the higher mortality in the United States compared to many European countries is explained by larger social disparities within the United States. We estimated the expected US mortality if educational disparities in the United States were similar to those in 7 European countries. Poisson models were used to quantify the association between education and mortality for men and women aged 30 to 74 years in the United States, Belgium, Denmark, Finland, France, Norway, Sweden, and Switzerland for the period 1989 to 2003. US data came from the National Health Interview Survey linked to the National Death Index and the European data came from censuses linked to national mortality registries. If people in the United States had the same distribution of education as their European counterparts, the US mortality disadvantage would be larger. However, if educational disparities in mortality within the United States equaled those within Europe, mortality differences between the United States and Europe would be reduced by 20% to 100%. Larger educational disparities in mortality in the United States than in Europe partly explain why US adults have higher mortality than their European counterparts. Policies to reduce mortality among the lower educated will be necessary to bridge the mortality gap between the United States and European countries.

  7. Notification: Audit of EPA Customer Service Help Desks, Hotlines, and Clearinghouses

    EPA Pesticide Factsheets

    Project #OA-FY12-0570, November 29, 2012. The EPA Office of Inspector General (OIG) plans to begin the fieldwork phase of our audit of EPA’s customer service help desks, hotlines, and clearinghouses (customer service lines).

  8. Notification: Audit of EPA Customer Service Help Desks, Hotlines, and Clearinghouses

    EPA Pesticide Factsheets

    Project #OA-FY12-0570, July 12, 2012. The EPA Office of Inspector General (OIG) plans to begin preliminary research on EPA’s customer service help desks, hotlines, and clearinghouses (contact centers).

  9. 78 FR 27129 - Proposed Priority and Requirements-Education Facilities Clearinghouse

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF EDUCATION 34 CFR Chapter II Proposed Priority and Requirements--Education Facilities Clearinghouse AGENCY: Office of Elementary and Secondary Education, Department of Education. ACTION: Proposed priority and...

  10. The clearinghouse concept: a model for geospatial data centralization and dissemination in a disaster.

    PubMed

    Mills, Jacqueline Warren; Curtis, Andrew; Pine, John C; Kennedy, Barrett; Jones, Farrell; Ramani, Ramesh; Bausch, Douglas

    2008-09-01

    The disaster clearinghouse concept originates with the earthquake community as an effort to coordinate research and data collection activities. Though prior earthquake clearinghouses are small in comparison to what was needed in response to Hurricane Katrina, these seminal structures are germane to the establishment of our current model. On 3 September 2005, five days after Katrina wrought cataclysmic destruction along the Gulf Coast, FEMA and Louisiana State University personnel met to establish the LSU GIS Clearinghouse Cooperative (LGCC), a resource for centralization and dissemination of geospatial information related to Hurricane Katrina. Since its inception, the LGCC has developed into a working model for organization, dissemination, archiving and research regarding geospatial information in a disaster. This article outlines the formation of the LGCC, issues of data organization, and methods of data dissemination and archiving with an eye towards implementing the clearinghouse model as a standard resource for addressing geospatial data needs in disaster research and management.

  11. Five Dimensions of European Identity: A Contribution to the Italian Adaptation and Validation of the In-Group Identification Scale

    PubMed Central

    La Barbera, Francesco; Capone, Vincenza

    2016-01-01

    Recent approaches define collective identity as a multi-component construct. Nonetheless, there is a lack of research about the dimensionality of in-group identification in relation to European Identity. Leach and colleagues (2008) proposed a framework of in-group identification, in which they distinguish five main components integrated into two higher-order dimensions. In two studies we examined the validity of the Italian version of the In-Group Identification Scale by Leach et al., with a focus on European identity. Confirmatory factor analyses revealed that the hierarchical model of in-group identification fitted the data well (Study 1); the measure was shown to have satisfactory convergent and divergent validity. In Study 2, the relations between European identification and several possible antecedents and outcomes were examined. PMID:27298637

  12. NASA's Eos ClearingHOuse: Integrating Access to Data Services

    NASA Astrophysics Data System (ADS)

    Burnett, M. T.; Pfister, R.; Wichman, K.

    2002-12-01

    ECHO (The Earth Observing System (EOS) ClearingHOuse) is being developed to provide flexibility to NASA's EOS to better meet the needs of the science community. ECHO is a clearinghouse of metadata, representing the data offerings of participating data providers. ECHO is being built with the goal of being an enabling system: Enabling a variety of Data Providers to participate. Enabling access to an ever-changing variety of Earth Science Data. Enabling access to an ever-growing suite of services, provided by the Science Community, which improves the usefulness of this data, including the binding of those services to the data represented in the clearinghouse. The purpose of this enabling philosophy is to support current Science efforts, but also to give the opportunity for creative organizations and individuals to break the traditional paradigm for discovering and leveraging Earth Science Data and Services in completely new ways. This presentation will focus on ECHO's approach to integrating Data Services from varied Service Providers, and facilitating access to those services by the user community. ECHO can be viewed as a typical Service oriented architecture. The fundamental interactions that it supports are (abstractly) Publish, Find and Bind. ECHO provides interfaces and mechanisms that allow organizations to publish their services. Using these interfaces, Service Providers can effectively "plug-in" their capabilities. There are mechanisms that allow the correlation of their service to the data types in the clearinghouse. ECHO's user community can find, or discover, services through a separate set of interfaces. Bindings are the mechanisms that support the invocation of services by ECHO's user community. ECHO supports binding either directly between the user and the service provider, or indirectly by using ECHO as a Service Broker. ECHO is supporting all of these Service capabilities by leveraging the contemporary (and evolving) "standards" of Web Services. Web

  13. Mitochondrial DNA D-loop haplogroup contributions to the genetic diversity of East European domestic chickens from Russia.

    PubMed

    Dyomin, A G; Danilova, M I; Mwacharo, J M; Masharsky, A E; Panteleev, A V; Druzhkova, A S; Trifonov, V A; Galkina, S A

    2017-04-01

    To elucidate geographical and historical aspects of chicken dispersal across Eastern Europe, we analysed the complete mitochondrial DNA D-loop sequence of 86 representatives from chicken breeds traditionally raised in the territory of the East European Plain (Orloff, Pavlov, Russian White, Yurlov Crower, Uzbek Game and Naked Neck). From the 1231-1232 bp D-loop sequence, 35 variable sites that defined 22 haplotypes were identified in modern chicken. All populations, except Uzbek Game, exhibited high values of haplotype and nucleotide diversity suggesting a wide variation in maternal diversity. Inclusion of mtDNA sequences from other European and Asian countries revealed representatives from this study belonging to haplogroups A, E1 and C1. We also assessed fossil chicken material dated to the 9th-18th century from archaeological sites in Northern and Eastern Europe. Three haplotypes found in the fossil specimens belonged to haplogroup E1, while one sample dated to the 18th century was assigned to the C1 haplogroup. This is the first report of the occurrence of the C1 haplogroup in European chicken populations prior to the 20th century based on the fossil material. These results provide evidence for a relatively recent introduction of all haplotypes other than E1 into the East European chicken gene pool with the significant impact of the C1 haplogroup mainly distributed in Southern China. © 2016 Blackwell Verlag GmbH.

  14. CD33 rs3865444 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese, European, and North American Populations.

    PubMed

    Li, Xingwang; Shen, Ning; Zhang, Shuyan; Liu, Jiafeng; Jiang, Qinghua; Liao, Mingzhi; Feng, Rennan; Zhang, Liangcai; Wang, Guangyu; Ma, Guoda; Zhou, Haihong; Chen, Zugen; Jiang, Yongshuai; Zhao, Bin; Li, Keshen; Liu, Guiyou

    2015-08-01

    The CD33 rs3865444 polymorphism was first identified to be associated with Alzheimer's disease (AD) in European population. However, the following studies reported weak or no significant association in Chinese, Japanese, Korean, American, and Canadian populations. We think that these negative results may have been caused by either relatively small sample sizes compared with those used for the previous GWAS in European ancestry or the genetic heterogeneity of the rs3865444 polymorphism in different populations. Here, we reevaluated this association using the relatively large-scale samples from previous 27 studies (N = 86,759; 31,106 cases and 55,653 controls) by searching the PubMed, AlzGene, and Google Scholar databases. We identified significant heterogeneity and observed no significant association between the rs3865444 polymorphism and AD in pooled populations (P = 0.264, odds ratio (OR) = 0.97, 95% confidence interval (CI) 0.93-1.02). In subgroup analysis, we identified significant heterogeneity only in East Asian population and observed no significant association between the rs3865444 polymorphism and AD. We further identified significant heterogeneity and observed significant association between the rs3865444 polymorphism and AD in Chinese population. We identified no significant heterogeneity and significant association in North American and European populations. Collectively, our analysis shows that the CD33 rs3865444 polymorphism is associated with AD susceptibility in Chinese, European, and North American populations. We believe that our findings will be very useful for future genetic studies on AD.

  15. Contribution of the spanish agency for medicines and healthcare products to the European committee for the evaluation of medicinal products for human use.

    PubMed

    Alonso-Gutiérrez, A; Díaz-Ramos, P; Sulleiro-Avendaño, E; de Miguel-Marañón, M; Padilla-Gallego, M E; Sancho-López, A; Ruiz-Antúnez, S; Prieto-Yerro, C

    2015-05-01

    The centralized procedure for registering medicinal products involves a joint assessment by all regulatory agencies of European Union member states, which are coordinated by the European Medicines Agency. Since its implementation in 1995, the Spanish Agency for Medicines and Healthcare Products (AEMPS) has actively contributed to the committee on medicinal products for human use. The therapeutic areas in which AEMPS has the greatest presence are cardiovascular, sensory organs (mainly ophthalmology) and genitourinary/sexual hormones. The technical staff of AEMPS contributes their expertise and extensive experience to this task, as do the practitioners of the Spanish healthcare system who act as external experts, providing their clinical vision and bringing the daily clinical practice to the evaluation of medicinal products. As with other European decision spaces, the joint participation of the member states is not homogeneous, with a minority of countries still heading the majority of assessments for the committee on medicinal products for human use, although all member countries take part in the final decision. Copyright © 2015 Elsevier España, S.L.U. y Sociedad Española de Medicina Interna (SEMI). All rights reserved.

  16. Mapping and converting essential Federal Geographic Data Committee (FGDC) metadata into MARC21 and Dublin Core: towards an alternative to the FGDC Clearinghouse

    USGS Publications Warehouse

    Chandler, A.; Foley, D.; Hafez, A.M.

    2000-01-01

    The purpose of this article is to raise and address a number of issues related to the conversion of Federal Geographic Data Committee metadata into MARC21 and Dublin Core. We present an analysis of 466 FGDC metadata records housed in the National Biological Information Infrastructure (NBII) node of the FGDC Clearinghouse, with special emphasis on the length of fields and the total length of records in this set. One of our contributions is a 34 element crosswalk, a proposal that takes into consideration the constraints of the MARC21 standard as implemented in OCLC's World Cat and the realities of user behavior.

  17. Rare, low frequency, and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans

    PubMed Central

    Olfson, Emily; Saccone, Nancy L.; Johnson, Eric O.; Chen, Li-Shiun; Culverhouse, Robert; Doheny, Kimberly; Foltz, Steven M.; Fox, Louis; Gogarten, Stephanie M.; Hartz, Sarah; Hetrick, Kurt; Laurie, Cathy C.; Marosy, Beth; Amin, Najaf; Arnett, Donna; Barr, R. Graham; Bartz, Traci M.; Bertelsen, Sarah; Borecki, Ingrid B.; Brown, Michael R.; Chasman, Daniel I.; van Duijn, Cornelia M.; Feitosa, Mary F.; Fox, Ervin R.; Franceschini, Nora; Franco, Oscar H.; Grove, Megan L.; Guo, Xiuqing; Hofman, Albert; Kardia, Sharon L.R.; Morrison, Alanna C.; Musani, Solomon K.; Psaty, Bruce M.; Rao, D.C.; Reiner, Alex P.; Rice, Kenneth; Ridker, Paul M.; Rose, Lynda M.; Schick, Ursula M.; Schwander, Karen; Uitterlinden, Andre G.; Vojinovic, Dina; Wang, Jen-Chyong; Ware, Erin B.; Wilson, Gregory; Yao, Jie; Zhao, Wei; Breslau, Naomi; Hatsukami, Dorothy; Stitzel, Jerry A.; Rice, John; Goate, Alison; Bierut, Laura J.

    2015-01-01

    The common nonsynonymous variant rs16969968 in the α5 nicotinic receptor subunit gene (CHRNA5) is the strongest genetic risk factor for nicotine dependence in European Americans and contributes to risk in African Americans. To comprehensively examine whether other CHRNA5 coding variation influences nicotine dependence risk, we performed targeted sequencing on 1582 nicotine dependent cases (Fagerström Test for Nicotine Dependence score≥4) and 1238 non-dependent controls, with independent replication of common and low frequency variants using 12 studies with exome chip data. Nicotine dependence was examined using logistic regression with individual common variants (MAF≥0.05), aggregate low frequency variants (0.05>MAF≥0.005), and aggregate rare variants (MAF<0.005). Meta-analysis of primary results was performed with replication studies containing 12 174 heavy and 11 290 light smokers. Next-generation sequencing with 180X coverage identified 24 nonsynonymous variants and 2 frameshift deletions in CHRNA5, including 9 novel variants in the 2820 subjects. Meta-analysis confirmed the risk effect of the only common variant (rs16969968, European ancestry: OR=1.3, p=3.5×10−11; African ancestry: OR=1.3, p=0.01) and demonstrated that 3 low frequency variants contributed an independent risk (aggregate term, European ancestry: OR=1.3, p=0.005; African ancestry: OR=1.4, p=0.0006). The remaining 22 rare coding variants were associated with increased risk of nicotine dependence in the European American primary sample (OR=12.9, p=0.01) and in the same risk direction in African Americans (OR=1.5, p=0.37). Our results indicate that common, low frequency and rare CHRNA5 coding variants are independently associated with nicotine dependence risk. These newly identified variants likely influence risk for smoking-related diseases such as lung cancer. PMID:26239294

  18. Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans.

    PubMed

    Olfson, E; Saccone, N L; Johnson, E O; Chen, L-S; Culverhouse, R; Doheny, K; Foltz, S M; Fox, L; Gogarten, S M; Hartz, S; Hetrick, K; Laurie, C C; Marosy, B; Amin, N; Arnett, D; Barr, R G; Bartz, T M; Bertelsen, S; Borecki, I B; Brown, M R; Chasman, D I; van Duijn, C M; Feitosa, M F; Fox, E R; Franceschini, N; Franco, O H; Grove, M L; Guo, X; Hofman, A; Kardia, S L R; Morrison, A C; Musani, S K; Psaty, B M; Rao, D C; Reiner, A P; Rice, K; Ridker, P M; Rose, L M; Schick, U M; Schwander, K; Uitterlinden, A G; Vojinovic, D; Wang, J-C; Ware, E B; Wilson, G; Yao, J; Zhao, W; Breslau, N; Hatsukami, D; Stitzel, J A; Rice, J; Goate, A; Bierut, L J

    2016-05-01

    The common nonsynonymous variant rs16969968 in the α5 nicotinic receptor subunit gene (CHRNA5) is the strongest genetic risk factor for nicotine dependence in European Americans and contributes to risk in African Americans. To comprehensively examine whether other CHRNA5 coding variation influences nicotine dependence risk, we performed targeted sequencing on 1582 nicotine-dependent cases (Fagerström Test for Nicotine Dependence score⩾4) and 1238 non-dependent controls, with independent replication of common and low frequency variants using 12 studies with exome chip data. Nicotine dependence was examined using logistic regression with individual common variants (minor allele frequency (MAF)⩾0.05), aggregate low frequency variants (0.05>MAF⩾0.005) and aggregate rare variants (MAF<0.005). Meta-analysis of primary results was performed with replication studies containing 12 174 heavy and 11 290 light smokers. Next-generation sequencing with 180 × coverage identified 24 nonsynonymous variants and 2 frameshift deletions in CHRNA5, including 9 novel variants in the 2820 subjects. Meta-analysis confirmed the risk effect of the only common variant (rs16969968, European ancestry: odds ratio (OR)=1.3, P=3.5 × 10(-11); African ancestry: OR=1.3, P=0.01) and demonstrated that three low frequency variants contributed an independent risk (aggregate term, European ancestry: OR=1.3, P=0.005; African ancestry: OR=1.4, P=0.0006). The remaining 22 rare coding variants were associated with increased risk of nicotine dependence in the European American primary sample (OR=12.9, P=0.01) and in the same risk direction in African Americans (OR=1.5, P=0.37). Our results indicate that common, low frequency and rare CHRNA5 coding variants are independently associated with nicotine dependence risk. These newly identified variants likely influence the risk for smoking-related diseases such as lung cancer.

  19. What Works to Overcome Indigenous Disadvantage: Key Learnings and Gaps in the Evidence. Closing the Gap Clearinghouse. 2009-10

    ERIC Educational Resources Information Center

    Al-Yaman, Fadwa; Higgins, Daryl

    2011-01-01

    The Closing the Gap Clearinghouse was established by the Council of Australian Governments (COAG) to bring together evidence-based research on overcoming disadvantage for Indigenous Australians. The Clearinghouse provides access to a collection of information on what works to improve Indigenous people's lives across the building blocks identified…

  20. The Retriever, Volume 2, Nos. 1 & 2, 1967. ERIC Clearinghouse on Rural Education and Small Schools (CRESS) Newsletter.

    ERIC Educational Resources Information Center

    ERIC Clearinghouse on Rural Education and Small Schools, Las Cruces, NM.

    Volume 2, Numbers 1 and 2 of the ERIC/CRESS (Educational Research Information Center/Clearinghouse on Rural education and Small Schools) newsletter focus on the status of CRESS and innovations in the small rural school. Issue Number 1 discusses the status of the Clearinghouse at the end of 3 months into the second year of operation. A 14-item…

  1. The Retriever, Volume 1, Number 1, Fall 1966. ERIC Clearinghouse on Rural Education and Small Schools (CRESS) Newsletter.

    ERIC Educational Resources Information Center

    ERIC Clearinghouse on Rural Education and Small Schools, Las Cruces, NM.

    The Educational Research Information Center (ERIC) is an educational information retrieval system. ERIC represents a decentralized, nationwide network of information Clearinghouses. Each Clearinghouse has its own area of subject specialization and retrieval responsibility, and is committed to acquiring, abstracting, indexing, storing, retrieving,…

  2. New insight into the history of domesticated apple: secondary contribution of the European wild apple to the genome of cultivated varieties.

    PubMed

    Cornille, Amandine; Gladieux, Pierre; Smulders, Marinus J M; Roldán-Ruiz, Isabel; Laurens, François; Le Cam, Bruno; Nersesyan, Anush; Clavel, Joanne; Olonova, Marina; Feugey, Laurence; Gabrielyan, Ivan; Zhang, Xiu-Guo; Tenaillon, Maud I; Giraud, Tatiana

    2012-01-01

    The apple is the most common and culturally important fruit crop of temperate areas. The elucidation of its origin and domestication history is therefore of great interest. The wild Central Asian species Malus sieversii has previously been identified as the main contributor to the genome of the cultivated apple (Malus domestica), on the basis of morphological, molecular, and historical evidence. The possible contribution of other wild species present along the Silk Route running from Asia to Western Europe remains a matter of debate, particularly with respect to the contribution of the European wild apple. We used microsatellite markers and an unprecedented large sampling of five Malus species throughout Eurasia (839 accessions from China to Spain) to show that multiple species have contributed to the genetic makeup of domesticated apples. The wild European crabapple M. sylvestris, in particular, was a major secondary contributor. Bidirectional gene flow between the domesticated apple and the European crabapple resulted in the current M. domestica being genetically more closely related to this species than to its Central Asian progenitor, M. sieversii. We found no evidence of a domestication bottleneck or clonal population structure in apples, despite the use of vegetative propagation by grafting. We show that the evolution of domesticated apples occurred over a long time period and involved more than one wild species. Our results support the view that self-incompatibility, a long lifespan, and cultural practices such as selection from open-pollinated seeds have facilitated introgression from wild relatives and the maintenance of genetic variation during domestication. This combination of processes may account for the diversification of several long-lived perennial crops, yielding domestication patterns different from those observed for annual species.

  3. New Insight into the History of Domesticated Apple: Secondary Contribution of the European Wild Apple to the Genome of Cultivated Varieties

    PubMed Central

    Cornille, Amandine; Gladieux, Pierre; Smulders, Marinus J. M.; Roldán-Ruiz, Isabel; Laurens, François; Le Cam, Bruno; Nersesyan, Anush; Clavel, Joanne; Olonova, Marina; Feugey, Laurence; Gabrielyan, Ivan; Zhang, Xiu-Guo; Tenaillon, Maud I.; Giraud, Tatiana

    2012-01-01

    The apple is the most common and culturally important fruit crop of temperate areas. The elucidation of its origin and domestication history is therefore of great interest. The wild Central Asian species Malus sieversii has previously been identified as the main contributor to the genome of the cultivated apple (Malus domestica), on the basis of morphological, molecular, and historical evidence. The possible contribution of other wild species present along the Silk Route running from Asia to Western Europe remains a matter of debate, particularly with respect to the contribution of the European wild apple. We used microsatellite markers and an unprecedented large sampling of five Malus species throughout Eurasia (839 accessions from China to Spain) to show that multiple species have contributed to the genetic makeup of domesticated apples. The wild European crabapple M. sylvestris, in particular, was a major secondary contributor. Bidirectional gene flow between the domesticated apple and the European crabapple resulted in the current M. domestica being genetically more closely related to this species than to its Central Asian progenitor, M. sieversii. We found no evidence of a domestication bottleneck or clonal population structure in apples, despite the use of vegetative propagation by grafting. We show that the evolution of domesticated apples occurred over a long time period and involved more than one wild species. Our results support the view that self-incompatibility, a long lifespan, and cultural practices such as selection from open-pollinated seeds have facilitated introgression from wild relatives and the maintenance of genetic variation during domestication. This combination of processes may account for the diversification of several long-lived perennial crops, yielding domestication patterns different from those observed for annual species. PMID:22589740

  4. Contribution of smoking-related and alcohol-related deaths to the gender gap in mortality: evidence from 30 European countries.

    PubMed

    McCartney, Gerry; Mahmood, Lamia; Leyland, Alastair H; Batty, G David; Hunt, Kate

    2011-03-01

    Women now outlive men throughout the globe, a mortality advantage that is very established in developed European countries. Debate continues about the causes of the gender gap, although smoking is known to have been a major contributor to the difference in the past. To compare the magnitude of the gender gap in all-cause mortality in 30 European countries and assess the contribution of smoking-related and alcohol-related deaths. Data on all-cause mortality, smoking-related mortality and alcohol-related mortality for 30 European countries were extracted from the World Health Organization Health for All database for the year closest to 2005. Rates were standardised by the direct method using the European population standard and were for all age groups. The proportion of the gender gap in all-cause mortality attributable to smoking-related and alcohol-related deaths was then calculated. There was considerable variation in the magnitude of the male 'excess' of all-cause mortality across Europe, ranging from 188 per 100, 000 per year in Iceland to 942 per 100, 000 per year in Ukraine. Smoking-related deaths accounted for around 40% to 60% of the gender gap, while alcohol-related mortality typically accounted for 20% to 30% of the gender gap in Eastern Europe and 10% to 20% elsewhere in Europe. Smoking continues to be the most important cause of gender differences in mortality across Europe, but its importance as an explanation for this difference is often overshadowed by presumptions about other explanations. Changes in smoking patterns by gender suggest that the gender gap in mortality will diminish in the coming decades.

  5. DOE`s Pollution Prevention Information Clearinghouse (EPIC)

    SciTech Connect

    Otis, P.T.

    1994-05-01

    The US Department of Energy`s (DOE`s) Pollution Prevention Information Clearinghouse (EPIC) is a computer system intended for the exchange of pollution prevention information DOE-wide. EPIC is being developed as a distributed system that will allow access to other databases and applications. The first prototype of EPIC (Prototype I) was put on-line in January 1994. Prototype I contains information on EM-funded pollution prevention projects; relevant laws, regulations, guidance, and policy; facility and DOE contacts; and meetings and conferences. Prototype I also gives users access to the INEL Hazardous Solvent Substitution Data System (HSSDS) and to information contained on the US Environmental Protection Agency`s (EPNS) Pollution Prevention Infbrmation Exchange System (PIES) as a test of the distributed system concept. An initial user group of about 35 is testing and providing feedback on Prototype I. Prototype II, with a Graphical User Interface (GUI), is planned for the end of CY94. This paper describes the current state of EPIC in terms of architecture, user interface, and information content. Plans for Prototype II and the final system are then discussed. The EPIC development effort is being coordinated with EPA and US Department of Defense (DoD) efforts to develop or upgrade their pollution prevention information exchange systems.

  6. The contributions of the European Medicines Agency and its pediatric committee to the fight against childhood leukemia

    PubMed Central

    Rose, Klaus; Walson, Philip D

    2015-01-01

    Background Although the diagnosis of childhood leukemia is no longer a death sentence, too many patients still die, more with acute myeloid leukemia than with acute lymphoblastic leukemia. The European Union pediatric legislation was introduced to improve pharmaceutical treatment of children, but some question whether the European Medicines Agency (EMA) approach is helping children with leukemia. Some have even suggested that the decisions of EMA pediatric committee (PDCO) are counterproductive. This study was designed to investigate the impact of PDCO-issued pediatric investigation plans (PIPs) for leukemia drugs. Methods All PIPs listed under “oncology” were downloaded from the EMA website. Non-leukemia decisions including misclassifications, waivers (no PIP), and solid tumors were discarded. The leukemia decisions were analyzed, compared to pediatric leukemia trials in the database http://www.clinicaltrials.gov, and discussed in the light of current literature. Results The PDCO leukemia decisions demand clinical trials in pediatric leukemia for all new adult drugs without prioritization. However, because leukemia in children is different and much rarer than in adults, these decisions have resulted in proposed studies that are scientifically and ethically questionable. They are also unnecessary, since once promising new compounds are approved for adults, more appropriate, prioritized pediatric leukemia trials are initiated worldwide without PDCO involvement. Conclusion EMA/PDCO leukemia PIPs do little to advance the treatment of childhood leukemia. The unintended negative effects of the flawed EMA/PDCO’s standardized requesting of non-prioritized testing of every new adult leukemia drug in children with relapsed or refractory disease expose these children to questionable trials, and could undermine public trust in pediatric clinical research. Institutions, investigators, and ethics committees/institutional review boards need to be skeptical of trials

  7. The contribution of educational class in improving accuracy of cardiovascular risk prediction across European regions: The MORGAM Project Cohort Component.

    PubMed

    Ferrario, Marco M; Veronesi, Giovanni; Chambless, Lloyd E; Tunstall-Pedoe, Hugh; Kuulasmaa, Kari; Salomaa, Veikko; Borglykke, Anders; Hart, Nigel; Söderberg, Stefan; Cesana, Giancarlo

    2014-08-01

    To assess whether educational class, an index of socioeconomic position, improves the accuracy of the SCORE cardiovascular disease (CVD) risk prediction equation. In a pooled analysis of 68 455 40-64-year-old men and women, free from coronary heart disease at baseline, from 47 prospective population-based cohorts from Nordic countries (Finland, Denmark, Sweden), the UK (Northern Ireland, Scotland), Central Europe (France, Germany, Italy) and Eastern Europe (Lithuania, Poland) and Russia, we assessed improvements in discrimination and in risk classification (net reclassification improvement (NRI)) when education was added to models including the SCORE risk equation. The lowest educational class was associated with higher CVD mortality in men (pooled age-adjusted HR=1.64, 95% CI 1.42 to 1.90) and women (HR=1.31, 1.02 to 1.68). In men, the HRs ranged from 1.3 (Central Europe) to 2.1 (Eastern Europe and Russia). After adjustment for the SCORE risk, the association remained statistically significant overall, in the UK and Eastern Europe and Russia. Education significantly improved discrimination in all European regions and classification in Nordic countries (clinical NRI=5.3%) and in Eastern Europe and Russia (NRI=24.7%). In women, after SCORE risk adjustment, the association was not statistically significant, but the reduced number of deaths plays a major role, and the addition of education led to improvements in discrimination and classification in the Nordic countries only. We recommend the inclusion of education in SCORE CVD risk equation in men, particularly in Nordic and East European countries, to improve social equity in primary prevention. Weaker evidence for women warrants the need for further investigations. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  8. Molecular genetic studies of natives on Easter Island: evidence of an early European and Amerindian contribution to the Polynesian gene pool.

    PubMed

    Lie, B A; Dupuy, B M; Spurkland, A; Fernández-Viña, M A; Hagelberg, E; Thorsby, E

    2007-01-01

    Most archaeological and linguistic evidence suggest a Polynesian origin of the population of Easter Island (Rapanui), and this view has been supported by the identification of Polynesian mitochondrial DNA (mtDNA) polymorphisms in prehistoric skeletal remains. However, some evidence of an early South American contact also exists (the sweet potato, bottle gourd etc.), but genetic studies have so far failed to show an early Amerindian contribution to the gene pool on Easter Island. To address this issue, we analyzed mtDNA and Y chromosome markers and performed high-resolution human leukocyte antigen (HLA) genotyping of DNA harvested from previously collected sera of 48 reputedly nonadmixed native Easter Islanders. All individuals carried mtDNA types and HLA alleles previously found in Polynesia, and most men carried Y chromosome markers of Polynesian origin, providing further evidence of a Polynesian origin of the population of Easter Island. A few individuals carried HLA alleles and/or Y chromosome markers of European origin. More interestingly, some individuals carried the HLA alleles A*0212 and B*3905, which are of typical Amerindian origin. The genealogy of some of the individuals carrying these non-Polynesian HLA alleles and their haplotypic backgrounds suggest an introduction into Easter Island in the early 1800s, or earlier. Thus, there may have been an early European and Amerindian contribution to the Polynesian gene pool of Easter Island.

  9. Contribution of ambient ozone to Scots pine defoliation and reduced growth in the Central European forests: a Lithuanian case study.

    PubMed

    Augustaitis, Algirdas; Bytnerowicz, Andrzej

    2008-10-01

    The study aimed to explore if changes in crown defoliation and stem growth of Scots pines (Pinus sylvestris L.) could be related to changes in ambient ozone (O(3)) concentration in central Europe. To meet this objective the study was performed in 3 Lithuanian national parks, close to the ICP integrated monitoring stations from which data on meteorology and pollution were provided. Contribution of peak O(3) concentrations to the integrated impact of acidifying compounds and meteorological parameters on pine stem growth was found to be more significant than its contribution to the integrated impact of acidifying compounds and meteorological parameters on pine defoliation. Findings of the study provide statistical evidence that peak concentrations of ambient O(3) can have a negative impact on pine tree crown defoliation and stem growth reduction under field conditions in central and northeastern Europe where the AOT40 values for forests are commonly below their phytotoxic levels.

  10. EarthSpace: The Higher Education Clearinghouse for Earth and Space Sciences

    NASA Astrophysics Data System (ADS)

    Dalton, H.; Cobabe-Ammann, E. A.; Shipp, S. S.

    2012-12-01

    EarthSpace is a searchable database of undergraduate classroom materials designed specifically for faculty teaching planetary sciences, Earth sciences, astrophysics, and solar and space physics at the introductory and upper division levels. Modeled after the highly successful SERC clearinghouse for geosciences assets, EarthSpace was designed for easy submission of classroom assets, from homework and computer interactives to laboratory exercises, lectures, and demonstrations. The site capabilities are being expanded to allow assignment of a unique Digital Object Identifier (DOI) to submitted materials, which will provide material developers a way to identify their submitted materials as publications on their CVs. EarthSpace materials are automatically cross-posted to other digital libraries (e.g., ComPADRE) and virtual higher education communities (e.g., Connexions), providing a wider distribution of the resources. In addition to classroom materials, EarthSpace provides the latest news and information about educational research and best practices, funding opportunities, and ongoing efforts and collaborations for undergraduate education. This information is emailed monthly in a newsletter to faculty members via the community mailing list, HENews. HENews is a place for the higher education community to share and receive news and information about higher education, teaching, and Earth and space science. EarthSpace also has an RSS feed to notify members when items are added. EarthSpace is a community-driven effort; higher education faculty members contribute and review materials and thus influence the content provided on the site. All materials are peer-reviewed before posting, and authors adhere to the Creative Commons Attribution (CC BY 3.0). You are invited to visit EarthSpace to search for teaching resources, submit your materials, or volunteer to review submitted resources in your discipline with a frequency designed to fit your schedule.

  11. Desert dust contribution to PM10 loads in Italy: Methods and recommendations addressing the relevant European Commission Guidelines in support to the Air Quality Directive 2008/50

    NASA Astrophysics Data System (ADS)

    Barnaba, Francesca; Bolignano, Andrea; Di Liberto, Luca; Morelli, Matteo; Lucarelli, Franco; Nava, Silvia; Perrino, Cinzia; Canepari, Silvia; Basart, Sara; Costabile, Francesca; Dionisi, Davide; Ciampichetti, Spartaco; Sozzi, Roberto; Gobbi, Gian Paolo

    2017-07-01

    In 2011 the European Commission (EC) released specific 'Guidelines' describing the methods to quantify and subtract the contribution of natural sources from the PM10 values regulated by the European Air Quality Directive (2008/50/EC). This work investigates the applicability to Italy of the EC-Methodology suggested for desert-dust, describes main limitations encountered and proposes specific modifications embedded within a 'revised-Methodology' to extend/improve its use. The revised-Methodology capabilities are evaluated using original, chemically-resolved mineral-dust mass concentration measurements, showing better performances in predicting timing and absolute values of the desert-dust contribution to the daily-PM10 with respect to the current EC-approach. The revised-Methodology is then translated into an automatic (user-independent) tool tailored to the expected final-users. This tool is applied over Central Italy across a 3-year long period (2012-2014), and over the whole Italian country for a calendar year (2012). The derived results confirm and extend to Italian regions never addressed before some previously observed features of the desert-dust impact over the country, such as a clear latitudinal dependence of the desert-dust impact on the yearly average PM10 (from more than 5 μg/m3 to less than 0.5 μg/m3, going from south to north Italy). The modifications introduced within the revised-Methodology also suggest a non-negligible role of desert-dust resuspension in areas characterized by both high traffic levels and soil sealing (urban areas and along the major Italian routes). In the Rome area, such an effect is found to add a contribution of about 2 μg/m3 (i.e., of 20%) to the mean desert-dust load per dust day (about 10 μg/m3). At the national level, this effect contributes increasing the total number of desert-dust-driven exceedances of the PM10 daily limit value even in the northern regions, where the desert-dust impact on the PM10 yearly average is

  12. The contribution of european projects in the cross-border management of drinking water: between hydrodynamics and vulnerability

    NASA Astrophysics Data System (ADS)

    Calligaris, Chiara; Cucchi, Franco; Turpaud, Philippe; Ravbar, Nataša; Petrič, Metka; Urbanc, Janko; Zini, Luca

    2017-04-01

    The Classical Karst Region represents an evolved binary karst hydrostructure located across NE Italy and SW Slovenia. Its deeply karstified limestones and dolomitic limestones swallow rainfall in a network of caves and fractures through the epikarst and vadose zones. In the phreatic zone, horizontal or sub-horizontal conduits quickly convey water to the springs. The aquifer is also recharged by the input of three rivers. Along its SE edge in Slovenia, the Reka River sinks entirely into the Škocjan caves. Along its NW edge, the Isonzo/Soča and Vipacco/Vipava rivers recharge the aquifer in a more diffuse manner as the input is supplied by porous aquifers alimented by riverbed leakages. The hydrostructure is drained by numerous springs situated NW of the plateau along its SE facing edge, between Monfalcone and Duino. The common average discharge of the Timavo spring is about 35.5 m3/s. The Reka-Timavo aquifer has attracted the attention of researchers for the last 200 years due to the increasing need for good quality drinking water. Water withdrawn in this area is guaranteed drinking water for the inhabitants of the Classical Karst. This water is supplied by AcegasApsAmga and Kra\\vski Vodovod delivering to more than 250.000 inhabitants. Since World War II, the Classical Karst Region has been politically divided. Consequently this area has been studied and managed separately for almost 70 years. Only recently has a collaboration between researchers of both countries begun. Within this framework is the 3-year Hydrokarst Project funded by the European Union which focussed on the joint protection and management of the cross border aquifer through the analysis of groundwater dynamics. The structuring and implementation of a shared geodatabase has allowed for the hydrochemical, hydrogeological and hydrodynamic characterisation of the aquifer. A second step consisted of the elaboration of a joint hydrogeological map. Thirdly, vulnerability mapping has allowed for the

  13. 45 CFR 2518.110 - What are the functions of a Service-Learning Clearinghouse?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... service-learning programs and participants in such programs; (e) Provide information, curriculum materials... 45 Public Welfare 4 2011-10-01 2011-10-01 false What are the functions of a Service-Learning...) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SERVICE-LEARNING CLEARINGHOUSE § 2518.110 What are...

  14. National Collegiate Software Clearinghouse Software for the Humanities and Social Sciences. Summer 1989 Catalog.

    ERIC Educational Resources Information Center

    National Collegiate Software Clearinghouse, Durham, NC.

    Over 250 microcomputer software packages, intended for use on MS-DOS machines by scholars and teachers in the humanities and social sciences, are included in this catalog. The clearinghouse's first Macintosh listing is included, with many more Macintosh programs and data sets being planned and tested for future inclusion. Most programs were…

  15. National Clearinghouse for Drug Abuse Information Report Series, Series 12, No. 1.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    Concerned with clarifying some of the more complex issues in drug abuse, the National Clearinghouse for Drug Abuse Information has prepared this special report on methadone. Background information is provided through a summary of its history, legal status, and the opinions of authorities in the field. Significant research on the subject is…

  16. National Clearinghouse for Drug Abuse Information Report Series, Series 25, No. 1.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    Concerned with clarifying some of the more complex issues in drug abuse, the National Clearinghouse for Drug Abuse Information has prepared this special report on methylenedioxyamphetamine (MDA), commonly called Mellow Drug of America. Background information is provided through a summary of its history, legal status, and the opinions of…

  17. National Clearinghouse for Drug Abuse Information Report Series, Series 15, No. 1.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    Concerned with clarifying some of the more complex issues in drug abuse, the National Clearinghouse for Drug Abuse Information has prepared this special report on mescaline. Background information is provided through a summary of its history, legal status, and the opinions of authorities in the field. Significant research on the subject is…

  18. Updated Design Standards and Guidance from the What Works Clearinghouse: Regression Discontinuity Designs and Cluster Designs

    ERIC Educational Resources Information Center

    Cole, Russell; Deke, John; Seftor, Neil

    2016-01-01

    The What Works Clearinghouse (WWC) maintains design standards to identify rigorous, internally valid education research. As education researchers advance new methodologies, the WWC must revise its standards to include an assessment of the new designs. Recently, the WWC has revised standards for two emerging study designs: regression discontinuity…

  19. Scott Foresman-Addison Wesley Elementary Mathematics. What Works Clearinghouse Intervention Report

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2010

    2010-01-01

    "Scott Foresman-Addison Wesley Elementary Mathematics" is a core curriculum for students at all ability levels in prekindergarten through grade 6. The program supports students' understanding of key math concepts and skills and covers a range of mathematical content across grades. The What Works Clearinghouse (WWC) reviewed 12 studies on…

  20. National Clearinghouse for Drug Abuse Information Report Series, Series 14, No. 1.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    Concerned with clarifying some of the more complex issues in drug abuse, the National Clearinghouse for Drug Abuse Information has prepared this special report on phencyclidine (PCP). Background information is provided through a summary of its history, legal status, and the opinions of authorities in the field. Significant research on the subject…

  1. The Missing Manual: Using National Student Clearinghouse Data to Track Postsecondary Outcomes

    ERIC Educational Resources Information Center

    Dynarski, Susan M.; Hemelt, Steven W.; Hyman, Joshua M.

    2015-01-01

    This article explores the promises and pitfalls of using National Student Clearinghouse (NSC) data to measure a variety of postsecondary outcomes. We first describe the history of the NSC, the basic structure of its data, and recent research interest in using NSC data. Second, using information from the Integrated Postsecondary Education Data…

  2. Procedures and Standards Handbook. Version 2.1. What Works Clearinghouse

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2011

    2011-01-01

    With its critical assessments of scientific evidence on the effectiveness of education programs, policies, and practices (referred to as "interventions"), and a range of products summarizing this evidence, the What Works Clearinghouse (WWC) is an important part of the Institute of Education Sciences' strategy to use rigorous and relevant…

  3. The Missing Manual: Using National Student Clearinghouse Data to Track Postsecondary Outcomes

    ERIC Educational Resources Information Center

    Dynarski, Susan M.; Hemelt, Steven W.; Hyman, Joshua M.

    2015-01-01

    This article explores the promises and pitfalls of using National Student Clearinghouse (NSC) data to measure a variety of postsecondary outcomes. We first describe the history of the NSC, the basic structure of its data, and recent research interest in using NSC data. Second, using information from the Integrated Postsecondary Education Data…

  4. News from International Clearinghouse on Children and Violence on the Screen (ICCVOS), 2002.

    ERIC Educational Resources Information Center

    von Feilitzen, Cecilia, Ed.

    2002-01-01

    This document is comprised of the two issues of the UNESCO International Clearinghouse on Children and Violence on the Screen's newsletter published in 2002, describing research findings concerning children and media violence, children's media use, and activities aimed at limiting gratuitous media violence. The first is a double issue that begins…

  5. News from International Clearinghouse on Children and Violence on the Screen (ICCVOS), 2001.

    ERIC Educational Resources Information Center

    von Feilitzen, Cecilia, Ed.

    2001-01-01

    This document represents the only issue of UNESCO International Clearinghouse on Children and Violence on the Screen's newsletter published in 2001. The report describes research findings concerning children and media violence, children's media use, and activities aimed at limiting gratuitous media violence. One article summarizes three workshops…

  6. News from the International Clearinghouse on Children and Violence on the Screen (ICCVOS), 2000.

    ERIC Educational Resources Information Center

    von Feilitzen, Cecilia, Ed.

    2000-01-01

    This document is comprised of the year 2000 reports from the UNESCO International Clearinghouse on Children and Violence on the Screen. The two issues describe research findings concerning children and media violence, children's media use, and activities aimed at limiting gratuitous media violence. The first issue includes articles addressing…

  7. Databases and Clearinghouses: Information Resources for Education. Information Series No. 167.

    ERIC Educational Resources Information Center

    Feaster, Thelma J.; And Others

    Databases and clearinghouses useful in education are described in this publication. Section one, "Databases," contains one-page summaries of 54 databases of interest to educators, covering a variety of subjects, such as energy and environmental education, psychology, funding sources, language, special education, art, child abuse and neglect, and…

  8. Oregon Intellectual Freedom Clearinghouse. Second Annual Report, July 1, 1988-June 30, 1989.

    ERIC Educational Resources Information Center

    Oregon State Library, Salem. Intellectual Freedom Clearinghouse.

    Challenges against library materials that were reported to the Oregon Intellectual Freedom Clearinghouse by Oregon libraries during its second full year of operation totalled 34 books, 13 of which were owned by public libraries and 21 by school libraries. The first challenge against an art exhibit in a public library was also reported. In 25 of…

  9. ERIC Clearinghouse for Science, Mathematics and Environmental Education, Information Bulletins, Nos. 1, 2, 3, 4, 1980.

    ERIC Educational Resources Information Center

    Blosser, Patricia E., Ed.

    Included are the four information bulletins produced by the ERIC Clearinghouse for Science, Mathematics and Environmental Education for the calendar year 1980. The first issue contains an interpretative summary from the National Council of Teachers of Mathematics project "Priorities in School Mathematics" as well as announcements of…

  10. What Works Clearinghouse Evidence Standards for Reviewing Studies, Version 1.0. Revised

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2008

    2008-01-01

    The Institute of Education Sciences (IES) and the What Works Clearinghouse (WWC) have identified topic areas that present a wide range of this nation's most pressing issues in education (e.g., middle school math, beginning reading, and character education). Within each selected topic area, the WWC collects studies of interventions (i.e., programs,…

  11. 45 CFR 2518.110 - What are the functions of a Service-Learning Clearinghouse?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false What are the functions of a Service-Learning... functions of a Service-Learning Clearinghouse? An organization that receives assistance from funds...-learning coordinators; and (j) Carry out such other activities as the Chief Executive Officer determines...

  12. 45 CFR 2518.110 - What are the functions of a Service-Learning Clearinghouse?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false What are the functions of a Service-Learning... functions of a Service-Learning Clearinghouse? An organization that receives assistance from funds...-learning coordinators; and (j) Carry out such other activities as the Chief Executive Officer determines...

  13. National Clearinghouse for Drug Abuse Information Report Series, Series 26, No. 1.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    Concerned with clarifying some of the more complex issues in drug abuse, the National Clearinghouse for Drug Abuse Information has prepared this special report on narcotic antagonists, particularly nalorphine, naloxone, cyclazocine, levallorphan, and pentazocine. Background information is provided through a summary of their history, legal status,…

  14. National Clearinghouse for Drug Abuse Information Report Series, Series 13, No. 1.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    Concerned with clarifying some of the more complex issues in drug abuse, the National Clearinghouse for Drug Abuse Information has prepared this special report on the British narcotics system. Underlying the British approach is the belief that narcotic dependence is a medical problem to be treated by medical professionals rather than a criminal…

  15. The Central Registry/Clearinghouse: A Tool for Improving the Child Support Enforcement Program.

    ERIC Educational Resources Information Center

    Cooper, Dennis C.; And Others

    Potential uses of a central registry/clearinghouse approach in the Child Support Enforcement Program (CSEP) are described in this publication. The CSEP was established in 1975 under Title IV-D of the Social Security Act in an effort to reduce federal monies spent supporting dependent children not receiving financial assistance from absent parents.…

  16. National Clearinghouse for Drug Abuse Information Report Series, Series 26, No. 1.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    Concerned with clarifying some of the more complex issues in drug abuse, the National Clearinghouse for Drug Abuse Information has prepared this special report on narcotic antagonists, particularly nalorphine, naloxone, cyclazocine, levallorphan, and pentazocine. Background information is provided through a summary of their history, legal status,…

  17. Tracking Community College Transfers Using National Student Clearinghouse Data. Professional File. Number 94, Winter 2005

    ERIC Educational Resources Information Center

    Romano, Richard M.; Wisniewski, Martin

    2005-01-01

    Accurate measures of transfer are important to the assessment of community college outcomes. This article uses a relatively new database from the National Student Clearinghouse to assess transfer rates at the State University of New York community colleges. Past studies only tracked students within the public sector of a given state. Once…

  18. National Clearinghouse for Drug Abuse Information Report Series, Series 16, No. 1.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    Concerned with clarifying some of the more complex issues in drug abuse, the National Clearinghouse for Drug Abuse Information has prepared this special report on psilocybin. Background information is provided through a summary of its history, legal status, and the opinions of authorities in the field. Significant research on the subject is…

  19. FFCAct Clearinghouse, directory of abstracts: Radioactive waste technical support program. Revision 2

    SciTech Connect

    1994-10-01

    The Federal Facility Compliance Act (FFCAct) Clearinghouse is a card catalog of information about the FFCAct and its requirements for developing Site Treatment Plans (STP). The information available in the clearinghouse includes abstracts describing computer applications, technical reports, and a list of technical experts. This report contains 61 abstracts from the database relating to radioactive waste management. The clearinghouse includes information on characterization, retrieval, treatment, storage, and disposal elements of waste management as they relate to the FFCAct and the treatment of mixed wastes. Subject areas of information being compiled include: commercial treatment capabilities; listings of technical experts for assistance in selecting and evaluating treatment options and technologies; mixed waste data and treatability groups; guidance on STP development; life-cycle costs planning estimates for facilities; references to documentation on available technologies and technology development activities; Waste Acceptance Criteria (WAC) for treatment facilities; regulatory, health and safety issues associated with treatment facilities and technologies; and computer databases, applications, and models for identifying and evaluating treatment facilities and technologies. Access to the FFCAct clearinghouse is available to the DOE and its DOE contractors involved in STP development and other FFCAct activities.

  20. National Collegiate Software Clearinghouse Software for the Humanities and Social Sciences. Summer 1989 Catalog.

    ERIC Educational Resources Information Center

    National Collegiate Software Clearinghouse, Durham, NC.

    Over 250 microcomputer software packages, intended for use on MS-DOS machines by scholars and teachers in the humanities and social sciences, are included in this catalog. The clearinghouse's first Macintosh listing is included, with many more Macintosh programs and data sets being planned and tested for future inclusion. Most programs were…

  1. The What Works Clearinghouse Single-Case Design Pilot Standards: Who Will Guard the Guards?

    ERIC Educational Resources Information Center

    Hitchcock, John H.; Horner, Robert H.; Kratochwill, Thomas R.; Levin, Joel R.; Odom, Samuel L.; Rindskopf, David M.; Shadish, William R.

    2014-01-01

    In this article, we respond to Wolery's critique of the What Works Clearinghouse (WWC) pilot "Standards," which were developed by the current authors. We do so to provide additional information and clarify some points previously summarized in this journal. We also respond to several concerns raised by Maggin, Briesch, and Chafouleas…

  2. National Clearinghouse for Drug Abuse Information Report Series, Series 16, No. 1.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    Concerned with clarifying some of the more complex issues in drug abuse, the National Clearinghouse for Drug Abuse Information has prepared this special report on psilocybin. Background information is provided through a summary of its history, legal status, and the opinions of authorities in the field. Significant research on the subject is…

  3. National Clearinghouse for Drug Abuse Information Report Series, Series 18, No. 1.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    Concerned with clarifying some of the more complex issues in drug abuse, the National Clearinghouse for Drug Abuse Information has prepared this special report on methaqualone. Background information is provided through a summary of its history, legal status, and the opinions of authorities in the field. Significant research on the subject is…

  4. The Potential for Development of a Clearinghouse for Emergency Information in the Public Library.

    ERIC Educational Resources Information Center

    Magrath, Lynn L.; Dowlin, Kenneth E.

    1987-01-01

    Presents the role of the Pikes Peak Library District's services in the creation and dissemination of an online clearinghouse in all four phases of emergency management: mitigation, preparedness, response, and recovery. Seven agencies and organizations involved in the network of community information that has been created are briefly described.…

  5. Successmaker®. What Works Clearinghouse Intervention Report. Updated November 2015

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2015

    2015-01-01

    The What Works Clearinghouse (WWC) has updated its 2009 intervention report for SuccessMaker®, a set of computer-based courses designed to supplement regular K-8 reading instruction. The program is designed to improve skills in areas such as concepts of print, phonological awareness, phonics, fluency, vocabulary, comprehension, grammar, and…

  6. Evidence Clearinghouses and Registries: Methods for Locating and Including Studies in Evidence Syntheses

    ERIC Educational Resources Information Center

    Foster, Lisa; LaSota, Robin; Yeide, Martha

    2015-01-01

    The purpose of this investigation is to report about study identification practices across evidence-based registries and clearinghouses in social policy fields, which serve as a resource for scientific, evidence-based decision-making about practices about desired outcomes in these social policy fields. The information retrieval procedures of the…

  7. National Clearinghouse for Drug Abuse Information Report Series, Series 11, No. 1.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    Concerned with clarifying some of the more complex issues in drug abuse, the National Clearinghouse for Drug Abuse Information has prepared this special report on cocaine. Background information is provided through a summary of its history, legal status, and the opinions of authorities in the field. Significant research on the subject is presented…

  8. 45 CFR 2518.110 - What are the functions of a Service-Learning Clearinghouse?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) Conduct research and evaluations concerning service-learning; (c)(1) Provide leadership development and... 45 Public Welfare 4 2012-10-01 2012-10-01 false What are the functions of a Service-Learning...) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SERVICE-LEARNING CLEARINGHOUSE § 2518.110 What are the...

  9. What Works Clearinghouse (WWC) Standards for Evaluating Single Case Designs (SCDs)

    ERIC Educational Resources Information Center

    Monahan, Shannon; Kratochwill, Thomas; Lipscomb, Stephen

    2011-01-01

    The What Works Clearinghouse (WWC) seeks to provide educators, policymakers, researchers, and the public with a central and trusted source of scientific evidence for what works in education. The WWC was established in 2002 by the U.S. Department of Education's Institute of Education Sciences (IES). It serves as a decision-making resource by…

  10. Overcoming Risk: An Annotated Bibliography of Publications Developed by ERIC Clearinghouses.

    ERIC Educational Resources Information Center

    Schwartz, Wendy, Ed.; Howley, Craig, Ed.

    This publication contains two essays and an annotated bibliography of publications about risk. The entries in the bibliography were produced by the various clearinghouses in the ERIC system. The first essay, "Who Is at Risk? Definitions, Demographics, and Decisions," by Aaron M. Pallas, categorizes personal, family, and environmental factors that…

  11. Melting pot of tick-borne zoonoses: the European hedgehog contributes to the maintenance of various tick-borne diseases in natural cycles urban and suburban areas.

    PubMed

    Jahfari, Setareh; Ruyts, Sanne C; Frazer-Mendelewska, Ewa; Jaarsma, Ryanne; Verheyen, Kris; Sprong, Hein

    2017-03-07

    European hedgehogs (Erinaceus europaeus) are urban dwellers and host both Ixodes ricinus and Ixodes hexagonus. These ticks transmit several zoonotic pathogens like Borrelia burgdorferi (sensu lato), Anaplasma phagocytophilum, Rickettsia helvetica, Borrelia miyamotoi and "Candidatus Neoehrlichia mikurensis". It is unclear to what extent hedgehogs in (sub) urban areas contribute to the presence of infected ticks in these areas, which subsequently pose a risk for acquiring a tick-borne disease. Therefore, it is important to investigate to what extent hedgehogs contribute to the enzootic cycle of these tick-borne pathogens, and to shed more light at the mechanisms of the transmission cycles involving hedgehogs and both ixodid tick species. Engorged ticks from hedgehogs were collected from (sub) urban areas via rehabilitating centres in Belgium. Ticks were screened individually for presence of Borrelia burgdorferi (sensu lato), Borrelia miyamotoi, Anaplasma phagocytophilum, Rickettsia helvetica and "Candidatus Neoehrlichia mikurensis" using PCR-based methods. Infection rates of the different pathogens in ticks were calculated and compared to infection rates in questing ticks. Both Ixodes hexagonus (n = 1132) and Ixodes ricinus (n = 73) of all life stages were found on the 54 investigated hedgehogs. Only a few hedgehogs carried most of the ticks, with 6 of the 54 hedgehogs carrying more than half of all ticks (624/1205). Borrelia miyamotoi, A. phagocytophilum, R. helvetica and B. burgdorferi genospecies (Borrelia afzelii, Borrelia bavariensis and Borrelia spielmanii) were detected in both I. hexagonus and I. ricinus. Anaplasma phagocytophilum, R. helvetica, B. afzelii, B. bavariensis and B. spielmanii were found significantly more in engorged ticks in comparison to questing I. ricinus. European hedgehogs seem to contribute to the spread and transmission of tick-borne pathogens in urban areas. The relatively high prevalence of B. bavariensis, B. spielmanii, B

  12. All part of the job? The contribution of the psychosocial and physical work environment to health inequalities in Europe and the European health divide.

    PubMed

    Toch, Marlen; Bambra, Clare; Lunau, Thorsten; van der Wel, Kjetil A; Witvliet, Margot I; Dragano, Nico; Eikemo, Terje A

    2014-01-01

    This study is the first to examine the contribution of both psychosocial and physical risk factors to occupational inequalities in self-assessed health in Europe. Data from 27 countries were obtained from the 2010 European Working Conditions Survey for men and women aged 16 to 60 (n = 21,803). Multilevel logistic regression analyses (random intercept) were applied, estimating odds ratios of reporting less than good health. Analyses indicate that physical working conditions account for a substantial proportion of occupational inequalities in health in both Central/Eastern and Western Europe. Physical, rather than psychosocial, working conditions seem to have the largest effect on self-assessed health in manual classes. For example, controlling for physical working conditions reduced the inequalities in the prevalence of"less than good health" between the lowest (semi- and unskilled manual workers) and highest (higher controllers) occupational groups in Europe by almost 50 percent (Odds Ratio 1.87, 95% Confidence Interval 1.62-2.16 to 1.42, 1.23-1.65). Physical working conditions contribute substantially to health inequalities across "post-industrial" Europe, with women in manual occupations being particularly vulnerable, especially those living in Central/Eastern Europe. An increased political and academic focus on physical working conditions is needed to explain and potentially reduce occupational inequalities in health.

  13. PCDD/Fs, DL-PCBs and NDL-PCBs in European catfish from a northern Italian lake: the contribution of an alien species to human exposure.

    PubMed

    Squadrone, S; Prearo, M; Nespoli, R; Scanzio, T; Abete, M C

    2016-03-01

    PCDDs/Fs, DL-PCBs and NDL-PCBs are environmentally persistent substances that have been associated with adverse effects on human health. Humans are mainly exposed to these pollutants through ingestion of contaminated fish and fishery products; the consumption of fatty fish such as European catfish can contribute considerably to the intake of dioxins and PCBs. Samples of fish muscle of the top-of-the-food-chain predator Silurus glanis from the northern Italian Lake Varese were analyzed to detect the levels of 17 PCDD/F and 18 PCB congeners. All samples presented detectable levels of PCDD/Fs and PCBs, with concentrations ranging from 0.001 to 1.310pgg(-1) wet weight (w.w.) for Σ PCDD/Fs, 0.031 to 21.000pgg(-1) w. w. for Σ DL-PCBs, and 0.397 to 117.910ngg(-1) w. w. for Σ NDL-PCBs. One sample exceeded the maximum levels of 6.5pgg(-1) w. w. for the sum of PCDD/Fs and DL-PCBs set by European regulations for fish (1259/2011 EU), while other samples exceeded the action levels of 0.75pgg(-1) w. w. for the sum of PCDD/Fs, and 2pgg(-1) w. w. for the sum of DL-PCBs (277/2012 EU). Consuming contaminated catfish may pose a risk for human health, especially for the subpopulation traditionally accustomed to eating this fish, as well as sensitive individuals, such as children and pregnant women.

  14. The Contribution of Common UGT2B10 and CYP2A6 Alleles to Variation in Nicotine Glucuronidation among European Americans

    PubMed Central

    Bloom, A. Joseph; von Weymarn, Linda B.; Martinez, Maribel; Bierut, Laura J.; Goate, Alison; Murphy, Sharon E.

    2014-01-01

    UDP-glucuronosytransferase-2B10 (UGT2B10) is the primary catalyst of nicotine glucuronidation. To develop a predictive genetic model of nicotine metabolism, the conversion of deuterated (D2)-nicotine to D2-nicotine-glucuronide, D2-cotinine, D2-cotinine-glucuronide, and D2-trans-3'-hydroxycotinine were quantified in 188 European Americans, and the contribution of UGT2B10 genotype to variability in first-pass nicotine glucuronidation assessed, following a procedure previously applied to nicotine C-oxidation. The proportion of total nicotine converted to nicotine-glucuronide (D2-nicotine-glucuronide/ (D2-nicotine +D2-nicotine-glucuronide +D2-cotinine +D2-cotinine-glucuronide +D2-trans-3'-hydroxycotinine)) was the primary phenotype. The variant, rs61750900T (D67Y) (minor allele frequency (MAF) = 10%), is confirmed to abolish nicotine glucuronidation activity. Another variant, rs112561475G (N397D) (MAF = 2%), is significantly associated with enhanced glucuronidation. rs112561475G is the ancestral allele of a well-conserved amino acid, indicating that the majority of human UGT2B10 alleles are derived hypomorphic alleles. CYP2A6 and UGT2B10 genotype explain 53% of the variance in oral nicotine glucuronidation in this sample. CYP2A6 and UGT2B10 genetic variants are also significantly associated with un-deuterated (D0) nicotine glucuronidation in subjects smoking ad libitum. We find no evidence for further common variation markedly influencing hepatic UGT2B10 expression in European Americans. PMID:24192532

  15. Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort

    PubMed Central

    2013-01-01

    Background Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential route to drug resistance, we developed a bioinformatics pipeline to detect superinfection from routinely collected genotyping data, and assessed whether superinfection contributed to increased drug resistance in a large European cohort of viremic, drug treated patients. Methods We used sequence data from routine genotypic tests spanning the protease and partial reverse transcriptase regions in the Virolab and EuResist databases that collated data from five European countries. Superinfection was indicated when sequences of a patient failed to cluster together in phylogenetic trees constructed with selected sets of control sequences. A subset of the indicated cases was validated by re-sequencing pol and env regions from the original samples. Results 4425 patients had at least two sequences in the database, with a total of 13816 distinct sequence entries (of which 86% belonged to subtype B). We identified 107 patients with phylogenetic evidence for superinfection. In 14 of these cases, we analyzed newly amplified sequences from the original samples for validation purposes: only 2 cases were verified as superinfections in the repeated analyses, the other 12 cases turned out to involve sample or sequence misidentification. Resistance to drugs used at the time of strain replacement did not change in these two patients. A third case could not be validated by re-sequencing, but was supported as superinfection by an intermediate sequence with high degenerate base pair count within the time frame of strain switching. Drug resistance increased in this single patient. Conclusions Routine genotyping data are informative for the detection of HIV superinfection; however, most cases of non-monophyletic clustering in patient

  16. Disaster Response and Decision Support in Partnership with the California Earthquake Clearinghouse

    NASA Astrophysics Data System (ADS)

    Glasscoe, M. T.; Rosinski, A.; Vaughan, D.; Morentz, J.

    2014-12-01

    Getting the right information to the right people at the right time is critical during a natural disaster. E-DECIDER (Emergency Data Enhanced Cyber-Infrastructure for Disaster Evaluation and Response) is a NASA decision support system designed to produce remote sensing and geophysical modeling data products that are relevant to the emergency preparedness and response communities and serve as a gateway to enable the delivery of NASA decision support products to these communities. The E-DECIDER decision support system has several tools, services, and products that have been used to support end-user exercises in partnership with the California Earthquake Clearinghouse since 2012, including near real-time deformation modeling results and on-demand maps of critical infrastructure that may have been potentially exposed to damage by a disaster. E-DECIDER's underlying service architecture allows the system to facilitate delivery of NASA decision support products to the Clearinghouse through XchangeCore Web Service Data Orchestration that allows trusted information exchange among partner agencies. This in turn allows Clearinghouse partners to visualize data products produced by E-DECIDER and other NASA projects through incident command software such as SpotOnResponse or ArcGIS Online.

  17. Quality Convergence Study: A Contribution to the Debates on Quality and Convergence in the European Higher Education Area. ENQA Occasional Papers 7

    ERIC Educational Resources Information Center

    Crozier, Fiona; Curvale, Bruno; Henard, Fabrice

    2005-01-01

    The Quality Convergence Study (QCS) project, a follow-up to a 2002 ENQA (European Association for Quality Assurance in Higher Education) survey of quality assurance practices in European countries, was carried out between September 2003 and October 2004. The project was coordinated by a project team consisting of representatives of ENQA member…

  18. Organizing and Making Sense of the Literature: Arthur M. Cohen as Director of the ERIC Clearinghouse for Community Colleges, 1966-2003

    ERIC Educational Resources Information Center

    Palmer, James C.

    2007-01-01

    A major part of Arthur M. Cohen's scholarly legacy is the archive of documents and journal articles catalogued by the ERIC Clearinghouse for Community Colleges, which he led throughout its entire 37-year history (1966-2003). As Clearinghouse director, Cohen oversaw its document acquisition and cataloguing operations, as well as its extensive…

  19. Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations.

    PubMed

    Org, Elin; Eyheramendy, Susana; Juhanson, Peeter; Gieger, Christian; Lichtner, Peter; Klopp, Norman; Veldre, Gudrun; Döring, Angela; Viigimaa, Margus; Sõber, Siim; Tomberg, Kärt; Eckstein, Gertrud; Kelgo, Piret; Rebane, Tiina; Shaw-Hawkins, Sue; Howard, Philip; Onipinla, Abiodun; Dobson, Richard J; Newhouse, Stephen J; Brown, Morris; Dominiczak, Anna; Connell, John; Samani, Nilesh; Farrall, Martin; Caulfield, Mark J; Munroe, Patricia B; Illig, Thomas; Wichmann, H-Erich; Meitinger, Thomas; Laan, Maris

    2009-06-15

    Hypertension is a complex disease that affects a large proportion of adult population. Although approximately half of the inter-individual variance in blood pressure (BP) level is heritable, identification of genes responsible for its regulation has remained challenging. Genome-wide association study (GWAS) is a novel approach to search for genetic variants contributing to complex diseases. We conducted GWAS for three BP traits [systolic and diastolic blood pressure (SBP and DBP); hypertension (HYP)] in the Kooperative Gesundheitsforschung in der Region Augsburg (KORA) S3 cohort (n = 1644) recruited from general population in Southern Germany. GWAS with 395,912 single nucleotide polymorphisms (SNPs) identified an association between BP traits and a common variant rs11646213 (T/A) upstream of the CDH13 gene at 16q23.3. The initial associations with HYP and DBP were confirmed in two other European population-based cohorts: KORA S4 (Germans) and HYPEST (Estonians). The associations between rs11646213 and three BP traits were replicated in combined analyses (dominant model: DBP, P = 5.55 x 10(-5), effect -1.40 mmHg; SBP, P = 0.007, effect -1.56 mmHg; HYP, P = 5.30 x 10(-8), OR = 0.67). Carriers of the minor allele A had a decreased risk of hypertension. A non-significant trend for association was also detected with severe family based hypertension in the BRIGHT sample (British). The novel susceptibility locus, CDH13, encodes for an adhesion glycoprotein T-cadherin, a regulator of vascular wall remodeling and angiogenesis. Its function is compatible with the BP biology and may improve the understanding of the pathogenesis of hypertension.

  20. The Early Contribution of Adult Education to the European Unification Process: The Genesis of the European Bureau of Adult Education and "Meeting Europe" Courses, 1950-1970. Research Bulletin 88.

    ERIC Educational Resources Information Center

    Toiviainen, Timo

    The beginning of organized European cooperation in adult education was the focus of a research study. A brief review of earlier research was conducted. Study findings indicated that, after World War II, Europe was less influential in issues of real significance in the world, with the Soviet Union dominating Eastern Europe and the center of power…

  1. Lower cardiorespiratory fitness contributes to increased insulin resistance and fasting glycaemia in middle-aged South Asian compared with European men living in the UK.

    PubMed

    Ghouri, N; Purves, D; McConnachie, A; Wilson, J; Gill, J M R; Sattar, N

    2013-10-01

    This study aimed to determine the extent to which increased insulin resistance and fasting glycaemia in South Asian men, compared with white European men, living in the UK, was due to lower cardiorespiratory fitness (maximal oxygen uptake [VO(2max)]) and physical activity. One hundred South Asian and 100 age- and BMI-matched European men without diagnosed diabetes, aged 40-70 years, had fasted blood taken for measurement of glucose concentration, HOMA-estimated insulin resistance (HOMA(IR)), plus other risk factors, and underwent assessment of physical activity (using accelerometry), VO(2max), body size and composition, and demographic and other lifestyle factors. For 13 South Asian and one European man, HbA1c levels were >6.5% (>48 mmol/mol), indicating potential undiagnosed diabetes; these men were excluded from the analyses. Linear regression models were used to determine the extent to which body size and composition, fitness and physical activity variables explained differences in HOMA(IR) and fasting glucose between South Asian and European men. HOMA(IR) and fasting glucose were 67% (p < 0.001) and 3% (p < 0.018) higher, respectively, in South Asians than Europeans. Lower VO(2max), lower physical activity and greater total adiposity in South Asians individually explained 68% (95% CI 45%, 91%), 29% (11%, 46%) and 52% (30%, 80%), respectively, and together explained 83% (50%, 119%) (all p < 0.001) of the ethnic difference in HOMA(IR). Lower VO(2max) and greater total adiposity, respectively, explained 61% (9%, 111%) and 39% (9%, 76%) (combined effect 63% [8%, 115%]; all p < 0.05) of the ethnic difference in fasting glucose. Lower cardiorespiratory fitness is a key factor associated with the excess insulin resistance and fasting glycaemia in middle-aged South Asian, compared with European, men living in the UK.

  2. The contributions of the European cosmetics industry to the development of alternatives to animal testing: dialogue with ECVAM and future challenges.

    PubMed

    de Silva, Odile

    2002-12-01

    COLIPA (the European Federation of the Cosmetics Industry) represents 24 international companies and 2000 small and medium-sized enterprises. Together with ECVAM, COLIPA has been involved in the development and validation of alternative methods since the beginning of the validation efforts. The work of the Steering Committee on Alternatives to Animal Testing (SCAAT) is based on collaboration between companies, but also with academia, trade associations, the Scientific Committee on Cosmetics and Non-Food Products (SCCNFP), European Commission Directorates General, and ECVAM. Some success has been achieved, but some validation efforts have failed. One lesson is that the search for alternatives requires a lot of humility.

  3. Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers.

    PubMed

    Court, Michael H; Zhu, Zhaohui; Masse, Gina; Duan, Su X; James, Laura P; Harmatz, Jerold S; Greenblatt, David J

    2017-09-01

    Over 30 years ago, black Africans from Kenya and Ghana were shown to metabolize acetaminophen faster by glucuronidation and slower by oxidation compared with white Scottish Europeans. The objectives of this study were to determine whether similar differences exist between African-Americans and European-Americans, and to identify genetic polymorphisms that could explain these potential differences. Acetaminophen plasma pharmacokinetics and partial urinary metabolite clearances via glucuronidation, sulfation, and oxidation were determined in healthy African-Americans (18 men, 23 women) and European-Americans (34 men, 20 women) following a 1-g oral dose. There were no differences in acetaminophen total plasma, glucuronidation, or sulfation clearance values between African-Americans and European-Americans. However, median oxidation clearance was 37% lower in African-Americans versus European-Americans (0.57 versus 0.90 ml/min per kilogram; P = 0.0001). Although acetaminophen total or metabolite clearance values were not different between genders, shorter plasma half-life values (by 11-14%; P < 0.01) were observed for acetaminophen, acetaminophen glucuronide, and acetaminophen sulfate in women versus men. The UGT2B15*2 polymorphism was associated with variant-allele-number proportional reductions in acetaminophen total clearance (by 15-27%; P < 0.001) and glucuronidation partial clearance (by 23-48%; P < 0.001). UGT2B15 *2/*2 genotype subjects also showed higher acetaminophen protein-adduct concentrations than *1/*2 (by 42%; P = 0.003) and *1/*1 (by 41%; P = 0.003) individuals. Finally, CYP2E1 *1D/*1D genotype African-Americans had lower oxidation clearance than *1C/*1D (by 42%; P = 0.041) and *1C/*1C (by 44%; P = 0.048) African-Americans. Consequently, African-Americans oxidize acetaminophen more slowly than European-Americans, which may be partially explained by the CYP2E1*1D polymorphism. UGT2B15*2 influences acetaminophen pharmacokinetics in both African

  4. New Directions in Library and Information Science Education. Final Report. Volume 2.7: Information Center/Clearinghouse Professional Competencies.

    ERIC Educational Resources Information Center

    Griffiths, Jose-Marie; And Others

    This document contains validated activities and competencies needed by information professionals working in an information center/clearinghouse. The activities and competencies are organized according to the functions which information center professionals perform: acquisitions; thesaurus development and control; indexing/abstracting;…

  5. An Overview of the ERIC Clearinghouse on Reading and Communication Skills. ERIC/RCS White Paper No. 1 (1990).

    ERIC Educational Resources Information Center

    Smith, Carl B.

    The Educational Resources Information Center (ERIC) is a national network of 16 specialized clearinghouses and several central ERIC service facilities, each of which is charged with enhancing the ERIC database of educational resources by identifying hard-to-find materials including research reports, curriculum guides, conference papers,…

  6. The What Works Clearinghouse: New Strategies to Support Non-Researchers in Using Rigorous Research in Education Decision-Making

    ERIC Educational Resources Information Center

    Seftor, Neil; Monahan, Shannon; McCutcheon, AnnaMaria

    2016-01-01

    The What Works Clearinghouse (WWC) is a central and trusted source of information of scientific evidence for what works in education. Towards that end, the WWC summarizes research on a range of practices, programs, and policies (interventions) and disseminates that research in a variety of forms on the free public website. In recent years, the WWC…

  7. Why "What Works" Still Doesn't Work: How to Improve Research Syntheses at the What Works Clearinghouse

    ERIC Educational Resources Information Center

    Lykins, Chad

    2012-01-01

    The What Works Clearinghouse (WWC) aims to synthesize and disseminate the results of high-quality education research on areas of significant public interest. The WWC has come to serve as a concrete example of the growing willingness of the federal government to shape both the topic and methods chosen by researchers. However, the scope of research…

  8. Drug Abuse Prevention: A Guide to Speakers. National Clearinghouse for Drug Abuse Information Report Series 19, No. 1.

    ERIC Educational Resources Information Center

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD. National Clearinghouse for Drug Abuse Information.

    This directory is intended as a resource for persons requiring knowledge about speaker's bureaus concerned with drug abuse prevention throughout the country. Information is derived from the National Clearinghouse for Drug Abuse Information National Inventory of Drug Abuse Programs, part of a comprehensive computerized information-retrieval system…

  9. State-based Marketplaces using 'clearinghouse' plan management models are associated with lower premiums.

    PubMed

    Krinn, Kelly; Karaca-Mandic, Pinar; Blewett, Lynn A

    2015-01-01

    The state-based and federally facilitated health insurance Marketplaces, or exchanges, enrolled more than eight million people during the first open enrollment period, which ended March 31, 2014. There is significant variation in how states have designed and implemented their Marketplaces. We examined how premiums varied with states' involvement in the Marketplaces through governance, plan management authority, and strategy during the first year that the exchanges have been open. State-based Marketplaces using "clearinghouse" plan management models had significantly lower adjusted average premiums for all plans within each metal level compared to state-based Marketplaces using "active purchaser" models and the federally facilitated and partnership Marketplaces. Clearinghouse management models are those in which all health plans that meet published criteria are accepted. Active purchaser models are those in which states negotiate premiums, provider networks, number of plans, and benefits. Our baseline estimates provide valuable benchmarks for evaluating future performance of states' involvement in governance, plan management, and regulatory authority of the insurance Marketplaces. Project HOPE—The People-to-People Health Foundation, Inc.

  10. Time, place, and people: composition of the EPIET Alumni Network and its contribution to the European public health resource in 2013.

    PubMed

    Pezzoli, L; Keramarou, M; Ladbury, G; Jaramillo-Gutierrez, G; Williams, C J; Le Menach, A

    2015-09-01

    The EPIET Alumni Network (EAN) is an association of professionals who have completed field epidemiology or public health microbiology training programmes in the European Union. In 2013, we conducted a survey of EAN members to investigate this network's role within European public health. We distributed an online questionnaire to members registered at the time, collecting data on demographics, professional background, and attitudes towards EAN. Out of 362 registered members, 189 (52%) responded; 97% were from Europe; 65% were female. Their mean age was 39 years. The highest academic qualification was PhD for 44% and Master's degree for 55%. The majority (60%) worked in public health institutes. They were especially satisfied with having access to job offers and professional networking via EAN, but requested more learning opportunities and knowledge-sharing between members. EAN is a unique platform where highly skilled professionals can connect to control infectious diseases locally and internationally. Having a network of professionals that know each other, speak the same 'language', and can easily access each other's expertise, represents an important resource for European and global public health, which should be nurtured by encouraging more collaborations devoted to professional development.

  11. California Earthquake Clearinghouse: Advocating for, and Advancing, Collaboration and Technology Interoperability, Between the Scientific and Emergency Response Communities, to Produce Actionable Intelligence for Situational Awareness, and Decision Support

    NASA Astrophysics Data System (ADS)

    Rosinski, A.; Beilin, P.; Colwell, J.; Hornick, M.; Glasscoe, M. T.; Morentz, J.; Smorodinsky, S.; Millington, A.; Hudnut, K. W.; Penn, P.; Ortiz, M.; Kennedy, M.; Long, K.; Miller, K.; Stromberg, M.

    2015-12-01

    The Clearinghouse provides emergency management and response professionals, scientific and engineering communities with prompt information on ground failure, structural damage, and other consequences from significant seismic events such as earthquakes or tsunamis. Clearinghouse activations include participation from Federal, State and local government, law enforcement, fire, EMS, emergency management, public health, environmental protection, the military, public and non-governmental organizations, and private sector. For the August 24, 2014 S. Napa earthquake, over 100 people from 40 different organizations participated during the 3-day Clearinghouse activation. Every organization has its own role and responsibility in disaster response; however all require authoritative data about the disaster for rapid hazard assessment and situational awareness. The Clearinghouse has been proactive in fostering collaboration and sharing Essential Elements of Information across disciplines. The Clearinghouse-led collaborative promotes the use of standard formats and protocols to allow existing technology to transform data into meaningful incident-related content and to enable data to be used by the largest number of participating Clearinghouse partners, thus providing responding personnel with enhanced real-time situational awareness, rapid hazard assessment, and more informed decision-making in support of response and recovery. The Clearinghouse efforts address national priorities outlined in USGS Circular 1242, Plan to Coordinate NEHRP post-earthquake investigations and S. 740-Geospatial Data Act of 2015, Sen. Orrin Hatch (R-UT), to streamline and coordinate geospatial data infrastructure, maximizing geospatial data in support of the Robert T. Stafford Act. Finally, the US Dept. of Homeland Security, Geospatial Management Office, recognized Clearinghouse's data sharing efforts as a Best Practice to be included in the forthcoming 2015 HLS Geospatial Concept of Operations.

  12. Contributions of the German Research Center for Geosciences (GFZ) to the EPOS Implementation Phase 2015-18 (European Plate Observing System)

    NASA Astrophysics Data System (ADS)

    Hoffmann, T. L.; Lauterjung, J.

    2016-12-01

    The European Plate Observing System project is currently approaching the end of year one of its four-year Implementation Phase 2015-18 (EPOS-IP). Established under the Horizon 2020 Programme INFRADEV-3, the EPOS cyberinfrastructure is being established as an ERIC (European Research Infrastructure Consortium) and encompasses the implementation of both the EPOS Integrated Core Services (ICS) for solid Earth Science and a multitude of EPOS Thematic Core Services (TCS). The TCS-Elements themselves will integrate a number of Service Providers that deliver Data, Data Products, Services and Software (DDSS) to their specific scientific community. As one of the 29 awardees of the EC grant, the German Research Center for Geosciences (GFZ) plays an important role in the implementation of EPOS and its Thematic and Integrated Core Services. The presented poster will give an overview of GFZ's participation in nine technical EPOS Work Packages (WP7 ICS Development, WP8 Seismology, WP11 Volcano Observations, WP12 Satellite Data, WP13 Geomagnetic Observations, WP14 Anthropogenic Hazards, WP15 Geological Information and Modelling, WP16 Multi-Scale Laboratories and WP17 Geo Energy Test Beds) as well as in four administrative EPOS Work Packages (WP2 Communication, WP3 Harmonization, WP4 Legal & Governance, and WP5 Financial).

  13. Characteristics of foodborne outbreaks in which use of analytical epidemiological studies contributed to identification of suspected vehicles, European Union, 2007 to 2011.

    PubMed

    Schlinkmann, K M; Razum, O; Werber, D

    2017-04-01

    Foodborne disease outbreaks (FBDOs) occur frequently in Europe. Employing analytical epidemiological study designs increases the likelihood of identifying the suspected vehicle(s), but these studies are rarely applied in FBDO investigations. We used multivariable binary logistic regression analysis to identify characteristics of investigated FBDOs reported to the European Food Safety Authority (2007-2011) that were associated with analytical epidemiological evidence (compared to evidence from microbiological investigations/descriptive epidemiology only). The analysis was restricted to FBDO investigations, where the evidence for the suspected vehicle was considered 'strong', i.e. convincing. The presence of analytical epidemiological evidence was reported in 2012 (50%) of these 4038 outbreaks. In multivariable analysis, increasing outbreak size, number of hospitalizations, causative (i.e. aetiological) agent (whether identified and, if so, which one), and the setting in which these outbreaks occurred (e.g. geographically dispersed outbreaks) were independently associated with presence of analytical evidence. The number of investigations with reported analytical epidemiological evidence was unexpectedly high, likely indicating the need for quality assurance within the European Union foodborne outbreak reporting system, and warranting cautious interpretation of our findings. This first analysis of evidence implicating a food vehicle in FBDOs may help to inform public health authorities on when to use analytical epidemiological study designs.

  14. The Inter-American Geospatial Data Network— developing a Western Hemisphere geospatial data clearinghouse

    USGS Publications Warehouse

    Anthony, Michelle L.; Klaver, Jacqueline M.; Quenzer, Robert

    1998-01-01

    The US Geological Survey and US Agency for International Development are enhancing the geographic information infrastructure of the Western Hemisphere by establishing the Inter-American Geospatial Data Network (IGDN). In its efforts to strengthen the Western Hemisphere's information infrastructure, the IGDN is consistent with the goals of the Plan of Action that emerged from the 1994 Summit of the Americas. The IGDN is an on-line cooperative, or clearinghouse, of geospatial data. Internet technology is used to facilitate the discovery and access of Western Hemisphere geospatial data. It was established by using the standards and guidelines of the Federal Geographic Data Committee to provide a consistent data discovery mechanism that will help minimize geospatial data duplication, promote data availability, and coordinate data collection and research activities.

  15. Contribution of prolonged-release melatonin and anti-benzodiazepine campaigns to the reduction of benzodiazepine and Z-drugs consumption in nine European countries.

    PubMed

    Clay, Emilie; Falissard, Bruno; Moore, Nicholas; Toumi, Mondher

    2013-04-01

    Benzodiazepines (BZD) and benzodiazepine receptor agonists (zolpidem, zaleplon, zopiclone, altogether Z-drugs) are most commonly prescribed for the treatment of insomnia. However, long-term use of BZD/Z-drugs is associated with major adverse events including, but not limited to, falls and fractures, domestic and traffic accidents, confusion, cognitive impairment, Alzheimer's disease and cancer. The prolonged use of these drugs is thought to be related to severe withdrawal symptoms and potential dependency. The chronic and extensive use of BZD/Z drugs has become a public health issue and has led to multiple campaigns to reduce both prescription and consumption of BZD/Z-drugs. Prolonged-release (PR) melatonin is the first of a new class of melatonin receptor agonist drugs that has demonstrated clinically relevant efficacy on improving quality of sleep and morning alertness, with a good safety profile. This study aimed to analyze and evaluate the impact of anti-BZD/Z-drugs campaigns and the availability of alternative pharmacotherapy (PR-melatonin) on the consumption of BZD and Z-drugs in several European countries. Annual sales data from nine European countries were extracted from the IMS sales database and analyzed to determine whether trends in use of these treatment options were attributed to campaigns and/or availability and affordability of safer alternatives on the market. Campaigns aiming to reduce the use of BZD/Z-drugs failed when they were not associated with the availability and market uptake of PR-melatonin. The reimbursement of PR-melatonin supports better penetration rates and a higher reduction in sales for BZD/Z-drugs.

  16. RACT/BACT/LAER Clearinghouse: A compilation of control technology determinations. Second supplement to the 1990 edition. Final report

    SciTech Connect

    Steigerwald, J.E.

    1992-07-01

    The Clean Air Act as amended in 1977 prescribes several technology-based limitations affecting new or modified air pollution sources: (1) new source performance stds. (NSPS); (2) best available control technology (BACT); and (3) lowest achievable emission rate (LAER). The basic purposes of the RACT/BACT/LAER Clearinghouse are to: (1) provide State and local air pollution control agencies with current information on case-by-case control technology determinations that are made nationwide and (2) promote communication, cooperation, and sharing of control technology information among the permitting agencies. The information presented in the compilation was abstracted from preconstruction permits and submitted voluntarily by the State and local air pollution control agencies. The Clearinghouse is intended as a reference for State and local agencies in making RACT/BACT/LAER decisions. Since the 1985 BLC document was published in June of that year, annual supplements containing only those determinations inserted or revised during the previous 12 months were published.

  17. A SensorML-based Metadata Model and Registry for Ocean Observatories: a Contribution from European Projects NeXOS and FixO3

    NASA Astrophysics Data System (ADS)

    Delory, E.; Jirka, S.

    2016-02-01

    Discovering sensors and observation data is important when enabling the exchange of oceanographic data between observatories and scientists that need the data sets for their work. To better support this discovery process, one task of the European project FixO3 (Fixed-point Open Ocean Observatories) is dealing with the question which elements are needed for developing a better registry for sensors. This has resulted in four items which are addressed by the FixO3 project in cooperation with further European projects such as NeXOS (http://www.nexosproject.eu/). 1.) Metadata description format: To store and retrieve information about sensors and platforms it is necessary to have a common approach how to provide and encode the metadata. For this purpose, the OGC Sensor Model Language (SensorML) 2.0 standard was selected. Especially the opportunity to distinguish between sensor types and instances offers new chances for a more efficient provision and maintenance of sensor metadata. 2.) Conversion of existing metadata into a SensorML 2.0 representation: In order to ensure a sustainable re-use of already provided metadata content (e.g. from ESONET-FixO3 yellow pages), it is important to provide a mechanism which is capable of transforming these already available metadata sets into the new SensorML 2.0 structure. 3.) Metadata editor: To create descriptions of sensors and platforms, it is not possible to expect users to manually edit XML-based description files. Thus, a visual interface is necessary to help during the metadata creation. We will outline a prototype of this editor, building upon the development of the ESONET sensor registry interface. 4.) Sensor Metadata Store: A server is needed that for storing and querying the created sensor descriptions. For this purpose different options exist which will be discussed. In summary, we will present a set of different elements enabling sensor discovery ranging from metadata formats, metadata conversion and editing to metadata

  18. Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.

    PubMed

    Hancock, D B; Guo, Y; Reginsson, G W; Gaddis, N C; Lutz, S M; Sherva, R; Loukola, A; Minica, C C; Markunas, C A; Han, Y; Young, K A; Gudbjartsson, D F; Gu, F; McNeil, D W; Qaiser, B; Glasheen, C; Olson, S; Landi, M T; Madden, P A F; Farrer, L A; Vink, J; Saccone, N L; Neale, M C; Kranzler, H R; McKay, J; Hung, R J; Amos, C I; Marazita, M L; Boomsma, D I; Baker, T B; Gelernter, J; Kaprio, J; Caporaso, N E; Thorgeirsson, T E; Hokanson, J E; Bierut, L J; Stefansson, K; Johnson, E O

    2017-10-03

    Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with sequence variants in nicotine acetylcholine receptor genes and at other loci. To search for additional loci, we conducted a genome-wide association study (GWAS) meta-analysis of nicotine dependence, totaling 38,602 smokers (28,677 Europeans/European Americans and 9925 African Americans) across 15 studies. In this largest-ever GWAS meta-analysis for nicotine dependence and the largest-ever cross-ancestry GWAS meta-analysis for any smoking phenotype, we reconfirmed the well-known CHRNA5-CHRNA3-CHRNB4 genes and further yielded a novel association in the DNA methyltransferase gene DNMT3B. The intronic DNMT3B rs910083-C allele (frequency=44-77%) was associated with increased risk of nicotine dependence at P=3.7 × 10(-8) (odds ratio (OR)=1.06 and 95% confidence interval (CI)=1.04-1.07 for severe vs mild dependence). The association was independently confirmed in the UK Biobank (N=48,931) using heavy vs never smoking as a proxy phenotype (P=3.6 × 10(-4), OR=1.05, and 95% CI=1.02-1.08). Rs910083-C is also associated with increased risk of squamous cell lung carcinoma in the International Lung Cancer Consortium (N=60,586, meta-analysis P=0.0095, OR=1.05, and 95% CI=1.01-1.09). Moreover, rs910083-C was implicated as a cis-methylation quantitative trait locus (QTL) variant associated with higher DNMT3B methylation in fetal brain (N=166, P=2.3 × 10(-26)) and a cis-expression QTL variant associated with higher DNMT3B expression in adult cerebellum from the Genotype-Tissue Expression project (N=103, P=3.0 × 10(-6)) and the independent Brain eQTL Almanac (N=134, P=0.028). This novel DNMT3B cis-acting QTL variant highlights the importance of genetically influenced regulation in brain on the risks of nicotine dependence, heavy smoking and consequent lung cancer

  19. Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American.

    PubMed

    Zhang, Tian-Xiao; Saccone, Nancy L; Bierut, Laura J; Rice, John P

    2017-04-01

    Smoking is a leading cause of preventable death. Early studies based on samples of twins have linked the lifetime smoking practices to genetic predisposition. The flavin-containing monooxygenase (FMO) protein family consists of a group of enzymes that metabolize drugs and xenobiotics. Both FMO1 and FMO3 were potentially susceptible genes for nicotine metabolism process. In this study, we investigated the potential of FMO genes to confer risk of nicotine dependence via deep targeted sequencing in 2,820 study subjects comprising 1,583 nicotine dependents and 1,237 controls from European American and African American. Specifically, we focused on the two genomic segments including FMO1,FMO3, and pseudo gene FMO6P, and aimed to investigate the potential association between FMO genes and nicotine dependence. Both common and low-frequency/rare variants were analyzed using different algorithms. The potential functional significance of SNPs with association signal was investigated with relevant bioinformatics tools. We identified different clusters of significant common variants in European (with most significant SNP rs6674596, p = .0004, OR = 0.67, MAF_EA = 0.14, FMO1) and African Americans (with the most significant SNP rs6608453, p = .001, OR = 0.64, MAF_AA = 0.1, FMO6P). No significant signals were identified through haplotype-based analyses. Gene network investigation indicated that both FMO1 and FMO3 have a strong relation with a variety of genes belonging to CYP gene families (with combined score greater than 0.9). Most of the significant variants identified were SNPs located within intron regions or with unknown functional significance, indicating a need for future work to understand the underlying functional significance of these signals. Our findings indicated significant association between FMO genes and nicotine dependence. Replications of our findings in other ethnic groups were needed in the future. Most of the significant variants identified were

  20. Contribution of hepatic cytochrome CYP1A and metallothionein mRNA abundance to biomonitoring-A case study with European flounder (Platichthys flesus) from the Gulf of Gdańsk.

    PubMed

    Kopecka-Pilarczyk, Justyna; Schirmer, Kristin

    2016-10-01

    The aim of the research was to explore the contribution of hepatic cytochrome CYP1A and metallothionein (MT) mRNA expression to biological effect monitoring. The study was conducted in the European flounder (Platichthys flesus) from the Gulf of Gdańsk. mRNA abundance was measured using reverse transcriptase polymerase chain reaction (RT-PCR) in liver RNA of fish sampled from three coastal stations and from one offshore station in the inner Gulf. The contribution of the mRNA-based biomarkers to the assessment of the environment was determined in conjunction with a selection of commonly applied biochemical markers: 7-ethoxyresorufin-O-deethylase (EROD), glutathione-S-transferase (GST), catalase (CAT), metallothioneins (MT), fluorescent aromatic compounds (FACs), all measured in the same individual fish. The mRNA biomarkers contributed to the separation between the sampling sites, but no correlations between CYP1A mRNA and EROD nor between MT mRNA and MT proteins were found, which should be attributed to the different levels these biomarkers correspond to and to the differences in factors that may affect them. One case of strong correlation between CYP1A mRNA and FACs was encountered. The overall results of this study suggest that biomarkers measured at the mRNA abundance level constitute a valuable addition to biomonitoring studies by providing additional information and contributing to the differentiation of results.

  1. Historic, pre-European settlement, and present-day contribution of wild ruminants to enteric methane emissions in the United States.

    PubMed

    Hristov, A N

    2012-04-01

    The objectives of this analysis were to estimate historic (pre-European settlement) enteric CH(4) emissions from wild ruminants in the contiguous United States and compare these with present-day CH(4) emissions from farmed ruminants. The analysis included bison, elk (wapiti), and deer (white-tailed and mule). Wild ruminants such as moose, antelope (pronghorn), caribou, and mountain sheep and goat were not included in the analysis because their natural range is mostly outside the contiguous United States or because they have relatively small population sizes. Data for presettlement and present-day population sizes, animal BW, feed intake, and CH(4) emission factors were adopted from various sources. Present-day CH(4) emissions from livestock were from recent United States Environmental Protection Agency estimates. The most important factor determining CH(4) emissions from wild ruminants in the presettlement period was the size of the bison population. Overall, enteric CH(4) emissions from bison, elk, and deer in the presettlement period were about 86% (assuming bison population size of 50 million) of the current CH(4) emissions from farmed ruminants in the United States. Present-day CH(4) emissions from wild ruminants (bison, elk, and deer) were estimated at 0.28 Tg/yr, or 4.3% of the emissions from domestic ruminants. Due to its population size (estimated at 25 million), the white-tailed deer is the most significant present-day wild ruminant contributor to enteric CH(4) emissions in the contiguous United States.

  2. European information on climate change impacts, vulnerability and adaptation

    NASA Astrophysics Data System (ADS)

    Jol, A.; Isoard, S.

    2010-09-01

    Vulnerability to natural and technological disasters is increasing due to a combination of intensifying land use, increasing industrial development, further urban expansion and expanding infrastructure and also climate change. At EU level the European Commission's White Paper on adaptation to climate change (published in 2009) highlights that adaptation actions should be focused on the most vulnerable areas and communities in Europe (e.g. mountains, coastal areas, river flood prone areas, Mediterranean, Arctic). Mainstreaming of climate change into existing EU policies will be a key policy, including within the Water Framework Directive, Marine Strategy Framework Directive, Nature protection and biodiversity policies, integrated coastal zone management, other (sectoral) policies (agriculture, forestry, energy, transport, health) and disaster risk prevention. 2010 is the international year on biodiversity and the Conference of Parties of the biodiversity convention will meet in autumn 2010 (Japan) to discuss amongst other post-2010 strategies, objectives and indicators. Both within the Biodiversity Convention (CBD) and the Climate Change Convention (UNFCCC) there is increasing recognition of the need for integration of biodiversity conservation into climate change mitigation and adaptation activities. Furthermore a number of European countries and also some regions have started to prepare and/or have adopted national adaptation plans or frameworks. Sharing of good practices on climate change vulnerability methods and adaptation actions is so far limited, but is essential to improve such plans, at national, sub national and local level where much of the adaptation action is already taking place and will be expanding in future, also involving increasingly the business community. The EU Clearinghouse on CC impacts, vulnerability and adaptation should address these needs and it is planned to be operational end of 2011. The EEA is expected to have a role in its

  3. Contributions of testosterone and territory ownership to sexually-motivated behaviors and mRNA expression in the medial preoptic area of male European starlings.

    PubMed

    Spool, Jeremy A; Stevenson, Sharon A; Angyal, Caroline S; Riters, Lauren V

    2016-11-01

    Animals integrate social information with their internal endocrine state to control the timing of behavior, but how these signals are integrated in the brain is not understood. The medial preoptic area (mPOA) may play an integrative role in the control of courtship behavior, as it receives projections from multiple sensory systems, and is central to the hormonal control of courtship behavior across vertebrates. Additionally, data from many species implicate opioid and dopaminergic systems in the mPOA in the control of male courtship behavior. We used European starlings to test the hypothesis that testosterone (T) and social status (in the form of territory possession) interact to control the timing of courtship behavior by modulating steroid hormone-, opioid- and dopaminergic-related gene expression in the mPOA. We found that only males given both T and a nesting territory produced high rates of courtship behavior in response to a female. T treatment altered patterns of gene expression in the mPOA by increasing androgen receptor, aromatase, mu-opioid receptor and preproenkephalin mRNA and decreasing tyrosine hydroxylase mRNA expression. Territory possession did not alter mRNA expression in the mPOA, despite the finding that only birds with both T and a nesting territory produced courtship behavior. We propose that T prepares the mPOA to respond to the presence of a female with high rates of courtship song by altering gene expression, but that activity in the mPOA is under a continuous (i.e. tonic) inhibition until a male starling obtains a nesting territory. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

    PubMed

    Egea, Javier; Fabregat, Isabel; Frapart, Yves M; Ghezzi, Pietro; Görlach, Agnes; Kietzmann, Thomas; Kubaichuk, Kateryna; Knaus, Ulla G; Lopez, Manuela G; Olaso-Gonzalez, Gloria; Petry, Andreas; Schulz, Rainer; Vina, Jose; Winyard, Paul; Abbas, Kahina; Ademowo, Opeyemi S; Afonso, Catarina B; Andreadou, Ioanna; Antelmann, Haike; Antunes, Fernando; Aslan, Mutay; Bachschmid, Markus M; Barbosa, Rui M; Belousov, Vsevolod; Berndt, Carsten; Bernlohr, David; Bertrán, Esther; Bindoli, Alberto; Bottari, Serge P; Brito, Paula M; Carrara, Guia; Casas, Ana I; Chatzi, Afroditi; Chondrogianni, Niki; Conrad, Marcus; Cooke, Marcus S; Costa, João G; Cuadrado, Antonio; My-Chan Dang, Pham; De Smet, Barbara; Debelec-Butuner, Bilge; Dias, Irundika H K; Dunn, Joe Dan; Edson, Amanda J; El Assar, Mariam; El-Benna, Jamel; Ferdinandy, Péter; Fernandes, Ana S; Fladmark, Kari E; Förstermann, Ulrich; Giniatullin, Rashid; Giricz, Zoltán; Görbe, Anikó; Griffiths, Helen; Hampl, Vaclav; Hanf, Alina; Herget, Jan; Hernansanz-Agustín, Pablo; Hillion, Melanie; Huang, Jingjing; Ilikay, Serap; Jansen-Dürr, Pidder; Jaquet, Vincent; Joles, Jaap A; Kalyanaraman, Balaraman; Kaminskyy, Danylo; Karbaschi, Mahsa; Kleanthous, Marina; Klotz, Lars-Oliver; Korac, Bato; Korkmaz, Kemal Sami; Koziel, Rafal; Kračun, Damir; Krause, Karl-Heinz; Křen, Vladimír; Krieg, Thomas; Laranjinha, João; Lazou, Antigone; Li, Huige; Martínez-Ruiz, Antonio; Matsui, Reiko; McBean, Gethin J; Meredith, Stuart P; Messens, Joris; Miguel, Verónica; Mikhed, Yuliya; Milisav, Irina; Milković, Lidija; Miranda-Vizuete, Antonio; Mojović, Miloš; Monsalve, María; Mouthuy, Pierre-Alexis; Mulvey, John; Münzel, Thomas; Muzykantov, Vladimir; Nguyen, Isabel T N; Oelze, Matthias; Oliveira, Nuno G; Palmeira, Carlos M; Papaevgeniou, Nikoletta; Pavićević, Aleksandra; Pedre, Brandán; Peyrot, Fabienne; Phylactides, Marios; Pircalabioru, Gratiela G; Pitt, Andrew R; Poulsen, Henrik E; Prieto, Ignacio; Rigobello, Maria Pia; Robledinos-Antón, Natalia; Rodríguez-Mañas, Leocadio; Rolo, Anabela P; Rousset, Francis; Ruskovska, Tatjana; Saraiva, Nuno; Sasson, Shlomo; Schröder, Katrin; Semen, Khrystyna; Seredenina, Tamara; Shakirzyanova, Anastasia; Smith, Geoffrey L; Soldati, Thierry; Sousa, Bebiana C; Spickett, Corinne M; Stancic, Ana; Stasia, Marie José; Steinbrenner, Holger; Stepanić, Višnja; Steven, Sebastian; Tokatlidis, Kostas; Tuncay, Erkan; Turan, Belma; Ursini, Fulvio; Vacek, Jan; Vajnerova, Olga; Valentová, Kateřina; Van Breusegem, Frank; Varisli, Lokman; Veal, Elizabeth A; Yalçın, A Suha; Yelisyeyeva, Olha; Žarković, Neven; Zatloukalová, Martina; Zielonka, Jacek; Touyz, Rhian M; Papapetropoulos, Andreas; Grune, Tilman; Lamas, Santiago; Schmidt, Harald H H W; Di Lisa, Fabio; Daiber, Andreas

    2017-10-01

    The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  5. European Contribution to Human Aspect Investigations for Future Planetary Habitat Definition Studies: Field Tests at MDRS on Crew Time Utilisation and Habitat Interfaces

    NASA Astrophysics Data System (ADS)

    Pletser, Vladimir; Foing, Bernard

    2011-02-01

    Human factors are a dominant aspect in space missions, which may strongly influence work results and efficiency. To assess their impact on future long term space missions and to attempt a general quantification, the environmental and technical conditions to which astronauts may be confronted need to be reproduced as closely as possible. Among the stressors that occur during space missions, limited resources, limited social interactions, long term living and working in confined and isolated areas are among the most important for future planetary exploration. The European Space Agency (ESA) has a strong interest in obtaining data and insights in human aspects to prepare for future studies on the definition of future Lunar and Martian planetary habitats. In this frame, ESA's Directorate of Human Space Flight was associated to the EuroGeoMars campaign conducted by the Crews 76 and 77 in February 2009 in The Mars Society's `Mars Desert Research Station' (MDRS) in the Desert of Utah. The EuroGeoMars Campaign lasted 5 weeks and encompassed two groups of experiments, on human crew related aspects and field experiments in geology, biology and astronomy/astrophysics. The human crew related aspects covered (1) crew time organization in a planetary habitat, (2) an evaluation of the different functions and interfaces of this habitat, (3) an evaluation of man-machine interfaces of science and technical equipment. Several forms and questionnaires were filled in by all crew members: time and location evaluation sheets and two series of questionnaires. In addition, the crew participated in another on-going food study where the type of food was imposed and crew impressions were collected via questionnaires. The paper recalls the objectives of the human crew related experiments of the EuroGeoMars project and presents the first results of these field investigations. Some recommendations and lessons learnt will be presented and used as first inputs for future planetary habitat

  6. Quantitatively probing water and its isotopomers: from theory to experiments; the contribution of a chemical and astrophysical European network 'Our Astrochemical History'

    NASA Astrophysics Data System (ADS)

    Wiesenfeld, Laurent

    2015-08-01

    In order to retrieve actual molecular abundances from astrophysical observations of molecular spectral lines, knowledge of the rotational levels excitation schemes is essential to go beyond Local Thermodynamical Equilibrium. These rates are almost always obtained from theoretical investigations, by computing classical or quantum dynamics of the interaction of molecules with these colliders (roueff2013).Our laboratories have recently calculated a set of collision coefficients characterizing the efficiency of energy transfer between molecular hydrogen of helium and a large variety of interstellar molecules. One of the main goal has been water and its isotopomers, computingrates for H2O, HDO and D2O in collision with H2 (valiron2008,faure2012,daniel2011).We felt it necessary to have a multidisciplinary approach: theoretical on the one hand, experimental on the second. Indeed, excitation coefficient computation is a process involving many codes and approximations. Hence we compared our theoretical results to several experiments: spectroscopy of the H2O-H2 van der Waals complex (vanderavoird 2012), differential cross sections (yang 2010, 2011), pressure broadening (drouin 2012).Thanks to these precise determinations, many water abundances could be quantitatively measured, like the HDO/H2O ratio (coutens 2012).While the excitation of water is by now well understood, much remains to be done for heavier molecules, paving the way to quantitative measures of complex organic molecules . A multi disciplinary approach is necessary, that keeps in mind the necessities of actual astrophysical observations. To do so, we describe the European COST network ‘Our Astrochemical History’ (http://prague2015astrohistory.vscht.cz/) , which brings together specialists of many areas of chemistry together with astronomy, in order to address this kind of problem. It focussses on the molecular evolution towards higher complexity and aim sat delivering new schemes for physical chemistry at

  7. European physics impact - to a first approximation

    NASA Astrophysics Data System (ADS)

    Starckx, Senne

    2013-05-01

    Physics-based industries contributed around 14%, or €3800bn, to the total value of the European economy in 2010 - exceeding that of the construction and retail sectors combined - according to a report by the European Physical Society (EPS).

  8. Mining User spatiotemporal Behavior in Geospatial Cyberinfrastructure --using GEOSS Clearinghouse as an example

    NASA Astrophysics Data System (ADS)

    XIA, J.; Yang, C.; Liu, K.; Huang, Q.; Li, Z.

    2013-12-01

    Big Data becomes increasingly important in almost all scientific domains, especially in geoscience where hundreds to millions of sensors are collecting data of the Earth continuously (Whitehouse News 2012). With the explosive growth of data, various Geospatial Cyberinfrastructure (GCI) (Yang et al. 2010) components are developed to manage geospatial resources and provide data access for the public. These GCIs are accessed by different users intensively on a daily basis. However, little research has been done to analyze the spatiotemporal patterns of user behavior, which could be critical to the management of Big Data and the operation of GCIs (Yang et al. 2011). For example, the spatiotemporal distribution of end users helps us better arrange and locate GCI computing facilities. A better indexing and caching mechanism could be developed based on the spatiotemporal pattern of user queries. In this paper, we use GEOSS Clearinghouse as an example to investigate spatiotemporal patterns of user behavior in GCIs. The investigation results show that user behaviors are heterogeneous but with patterns across space and time. Identified patterns include (1) the high access frequency regions; (2) local interests; (3) periodical accesses and rush hours; (4) spiking access. Based on identified patterns, this presentation reports several solutions to better support the operation of the GEOSS Clearinghouse and other GCIs. Keywords: Big Data, EarthCube, CyberGIS, Spatiotemporal Thinking and Computing, Data Mining, User Behavior Reference: Fayyad, U. M., Piatetsky-Shapiro, G., Smyth, P., & Uthurusamy, R. 1996. Advances in knowledge discovery and data mining. Whitehouse. 2012. Obama administration unveils 'BIG DATA' initiative: announces $200 million in new R&D investments. Whitehouse. Retrieved from http://www.whitehouse.gov/sites/default/files/microsites/ostp/big_data_press_release_final_2.pdf [Accessed 14 June 2013] Yang, C., Wu, H., Huang, Q., Li, Z., & Li, J. 2011. Using spatial

  9. Contributing Data to the Fleet DNA Project (Brochure)

    SciTech Connect

    Not Available

    2014-09-01

    The Fleet DNA clearinghouse of commercial fleet transportation data helps vehicle manufacturers and developers optimize vehicle designs and helps fleet managers choose advanced technologies for their fleets. This online tool - available at www.nrel.gov/fleetdna - provides data summaries and visualizations similar to real-world 'genetics' for medium- and heavy-duty commercial fleet vehicles operating within a variety of vocations. To contribute your fleet data, please contact Adam Duran of the U.S. Department of Energy's National Renewable Energy Laboratory (NREL) at adam.duran@nrel.gov or 303-275-4586.

  10. Earthspace: A National Clearinghouse For Higher Education In Space And Earth Sciences

    NASA Astrophysics Data System (ADS)

    CoBabe-Ammann, Emily; Shipp, S.; Dalton, H.

    2012-10-01

    The EarthSpace is a searchable database of undergraduate classroom materials for undergraduate faculty teaching earth and space sciences at both the introductory and upper division levels. Modeled after the highly successful SERC clearinghouse for geosciences assets, EarthSpace was designed for easy submission of classroom assets - from homeworks and computerinteractives to laboratories and demonstrations. All materials are reviewedbefore posting, and authors adhere to the Creative Commons Non-Commercial Attribution (CC-BY NC 3.0). If authors wish, their EarthSpace materials are automatically cross-posted to other digital libraries (e.g., ComPADRE) and virtual higher education communities(e.g., Connexions). As new electronic repositories come online, EarthSpace materials will automatically be sent. So faculty submit their materials only once and EarthSpace ensures continual distribution as time goes on and new opportunities arise. In addition to classroom materials, EarthSpace provides news and information about educational research and best practices, funding opportunities, and ongoing efforts and collaborations for undergraduate education. http://www.lpi.usra.edu/earthspace

  11. Spatial distribution of trace elements in the surface sediments of a major European estuary (Loire Estuary, France): Source identification and evaluation of anthropogenic contribution

    NASA Astrophysics Data System (ADS)

    Coynel, Alexandra; Gorse, Laureline; Curti, Cécile; Schafer, Jörg; Grosbois, Cécile; Morelli, Guia; Ducassou, Emmanuelle; Blanc, Gérard; Maillet, Grégoire M.; Mojtahid, Meryem

    2016-12-01

    Assessing the extent of metal contamination in estuarine surface sediments is hampered by the high heterogeneity of sediment characteristics, the spatial variability of trace element sources, sedimentary dynamics and geochemical processes in addition to the need of accurate reference values for deciphering natural to anthropogenic contribution. Based on 285 surface sediment samples from the Loire Estuary, the first high-resolution spatial distributions are presented for grain-size, particulate organic carbon (POC) and the eight metals/metalloids identified as priority contaminants (Cd, Zn, Pb, Cu, As, Cr, Ni, Hg) plus Ag (an urban tracer). Grain-size and/or POC are major factors controlling the spatial distribution of trace element concentrations. The V-normalized trace metal concentrations divided by the V-normalized concentrations in the basin geochemical background showed the highest Enrichment Factors for Ag and Hg (EF; up to 34 and 140, respectively). These results suggest a severe contamination in the Loire Estuary for both elements. Intra-estuarine Ag and Hg anomalies were identified by comparison between respective normalized concentrations in the Loire Estuary surface sediments and those measured in the surface sediments at the outlet of the Loire River System (watershed-derived). Anthropogenic intra-estuarine Ag and Hg stocks in the uppermost centimetre of the sediment compared with rough annual fluvial flux estimates suggest that the overall strong Enrichment Factors for Ag (EFAg) and and Hg (EFHg) in the Loire Estuary sediments are mainly due to watershed-derived inputs, highlighting the need of high temporal hydro-geochemical monitoring to establish reliable incoming fluxes. Significant correlations obtained between EFCd and EFAg, EFCu and POC and EFHg and POC revealed common behavior and/or sources. Comparison of trace element concentrations with ecotoxicological indices (Sediment Quality Guidelines) provides first standardized information on the

  12. The contribution of risk factors to the higher incidence of invasive and in situ breast cancers in women with higher levels of education in the European prospective investigation into cancer and nutrition

    PubMed Central

    Menvielle, Gwenn; Kunst, Anton E.; Van Gils, Carla H.; Peeters, Petra H. M.; Boshuizen, Hendriek; Overvad, Kim; Olsen, Anja; Tjonneland, Anne; Hermann, Silke; Kaaks, Rudolf; Bergmann, Manuela M.; Illner, Anne-Kathrin; Lagiou, Pagona; Trichopoulos, Dimitrios; Trichopoulou, Antonia; Palli, Domenico; Berrino, Franco; Mattiello, Amelia; Tumino, Rosario; Sacerdote, Carlotta; May, Anne; Monninkhof, Evelyn; Braaten, Tonje; Lund, Eiliv; Quirós, José Ramón; Duell, Eric J.; Sánchez, Maria-José; Navarro, Carmen; Ardanaz, Eva; Borgquist, Signe; Manjer, Jonas; Khaw, Kay Tee; Allen, Naomi E.; Reeves, Gillian K.; Chajes, Véronique; Rinaldi, Sabina; Slimani, Nadia; Gallo, Valentina; Vineis, Paolo; Riboli, Elio; Bueno-de-Mesquita, H Bas

    2011-01-01

    This paper aims to investigate the role of known risk factors in explaining educational differences in breast cancer incidence. Analyses were based on the European Prospective Investigation into Cancer and Nutrition, and included 242,095 women, 433 in situ and 4,469 invasive breast cancers. Reproductive history (age at first full term pregnancy and parity), exposure to endogenous and exogenous hormones, height, and health behaviours were accounted for in the analyses. Relative indices of inequality (RII) for education were estimated using Cox regression models. Higher invasive breast cancer risk was found among women with higher education (RII=1.22: 1.09,1.37). This association was not observed among nulliparous women (RII=1.13: 0.84,1.52). Inequalities in breast cancer incidence decreased substantially after adjusting for reproductive history (RII=1.11: 0.98,1.25), most of the association being explained by age at first full term pregnancy. Each other risk factor explained a small additional part of inequalities in breast cancer incidence. Height contributed most of these factors. When all known risk factors were adjusted for, no association remained between education and invasive breast cancer risk. Inequalities in incidence were more pronounced for in situ breast cancers and remained after adjustment for all known risk factors (RII=1.61: 1.07,2.41), especially among nulliparous women. PMID:21084553

  13. Assessing the Feasibility of a Test Item Bank and Assessment Clearinghouse: Strategies to Measure Technical Skill Attainment of Career and Technical Education Participants

    ERIC Educational Resources Information Center

    Derner, Seth; Klein, Steve; Hilber, Don

    2008-01-01

    This report documents strategies that can be used to initiate development of a technical skill test item bank and/or assessment clearinghouse and quantifies the cost of creating and maintaining such a system. It is intended to inform state administrators on the potential uses and benefits of system participation, test developers on the needs and…

  14. Teaching Strategies for Improving Algebra Knowledge in Middle and High School Students. Educator's Practice Guide. What Works Clearinghouse.™ NCEE 2015-4010

    ERIC Educational Resources Information Center

    Star, Jon R.; Foegen, Anne; Larson, Matthew R.; McCallum, William G.; Porath, Jane; Zbiek, Rose Mary; Caronongan, Pia; Furgeson, Joshua,; Keating, Betsy; Lyskawa, Julia

    2015-01-01

    Mastering algebra is important for future math and postsecondary success. Educators will find practical recommendations for how to improve algebra instruction in the What Works Clearinghouse (WWC) practice guide, "Teaching Strategies for Improving Algebra Knowledge in Middle and High School Students". The methods and examples included in…

  15. Alignment of Single-Case Design (SCD) Research with Individuals Who Are Deaf or Hard of Hearing with the What Works Clearinghouse Standards for SCD Research

    ERIC Educational Resources Information Center

    Wendel, Erica; Cawthon, Stephanie W.; Ge, Jin Jin; Beretvas, S. Natasha

    2015-01-01

    The authors assessed the quality of single-case design (SCD) studies that assess the impact of interventions on outcomes for individuals who are deaf or hard-of-hearing (DHH). More specifically, the What Works Clearinghouse (WWC) standards for SCD research were used to assess design quality and the strength of evidence of peer-reviewed studies…

  16. Alignment of Single-Case Design (SCD) Research with Individuals Who Are Deaf or Hard of Hearing with the What Works Clearinghouse Standards for SCD Research

    ERIC Educational Resources Information Center

    Wendel, Erica; Cawthon, Stephanie W.; Ge, Jin Jin; Beretvas, S. Natasha

    2015-01-01

    The authors assessed the quality of single-case design (SCD) studies that assess the impact of interventions on outcomes for individuals who are deaf or hard-of-hearing (DHH). More specifically, the What Works Clearinghouse (WWC) standards for SCD research were used to assess design quality and strength of evidence of peer-reviewed studies…

  17. Department of Education: Improved Dissemination and Timely Product Release Would Enhance the Usefulness of the What Works Clearinghouse. Report to Congressional Committees. GAO-10-644

    ERIC Educational Resources Information Center

    Ashby, Cornelia M.

    2010-01-01

    In connection with the Omnibus Appropriations Act, 2009, GAO (Government Accountability Office) was required to study the What Works Clearinghouse (WWC), a federal source of evidence about effective education practices. Operating through a 5-year contract awarded by the U.S. Department of Education's Institute of Education Sciences (IES), the WWC…

  18. Lifelong Learning and Its Impact on Social and Regional Development. Contributions to the European Conference on Lifelong Learning (1st, Bremen, Germany, October 3-5, 1996). Collected Papers.

    ERIC Educational Resources Information Center

    Alheit, Peter, Ed.; Kammler, Eva, Ed.

    This book contains 56 papers from a European conference. Representative papers include the following: "Adult Education, European Citizenship and the Role of the Regions" (Sussmuth); "Can Lifelong Learning Prevent the Breakdown of Society?" (Young); "Two Challenges to a Modern Concept of Lifelong Learning" (Alheit);…

  19. Lifelong Learning and Its Impact on Social and Regional Development. Contributions to the European Conference on Lifelong Learning (1st, Bremen, Germany, October 3-5, 1996). Collected Papers.

    ERIC Educational Resources Information Center

    Alheit, Peter, Ed.; Kammler, Eva, Ed.

    This book contains 56 papers from a European conference. Representative papers include the following: "Adult Education, European Citizenship and the Role of the Regions" (Sussmuth); "Can Lifelong Learning Prevent the Breakdown of Society?" (Young); "Two Challenges to a Modern Concept of Lifelong Learning" (Alheit);…

  20. ISO 19115 Experiences in NASA's Earth Observing System (EOS) ClearingHOuse (ECHO)

    NASA Astrophysics Data System (ADS)

    Cechini, M. F.; Mitchell, A.

    2011-12-01

    Metadata is an important entity in the process of cataloging, discovering, and describing earth science data. As science research and the gathered data increases in complexity, so does the complexity and importance of descriptive metadata. To meet these growing needs, the metadata models required utilize richer and more mature metadata attributes. Categorizing, standardizing, and promulgating these metadata models to a politically, geographically, and scientifically diverse community is a difficult process. An integral component of metadata management within NASA's Earth Observing System Data and Information System (EOSDIS) is the Earth Observing System (EOS) ClearingHOuse (ECHO). ECHO is the core metadata repository for the EOSDIS data centers providing a centralized mechanism for metadata and data discovery and retrieval. ECHO has undertaken an internal restructuring to meet the changing needs of scientists, the consistent advancement in technology, and the advent of new standards such as ISO 19115. These improvements were based on the following tenets for data discovery and retrieval: + There exists a set of 'core' metadata fields recommended for data discovery. + There exists a set of users who will require the entire metadata record for advanced analysis. + There exists a set of users who will require a 'core' set metadata fields for discovery only. + There will never be a cessation of new formats or a total retirement of all old formats. + Users should be presented metadata in a consistent format of their choosing. In order to address the previously listed items, ECHO's new metadata processing paradigm utilizes the following approach: + Identify a cross-format set of 'core' metadata fields necessary for discovery. + Implement format-specific indexers to extract the 'core' metadata fields into an optimized query capability. + Archive the original metadata in its entirety for presentation to users requiring the full record. + Provide on-demand translation of

  1. RACT/BACT/LAER clearinghouse: A compilation of control technology determinations. Third supplement to the 1990 edition. Volume 1

    SciTech Connect

    Steigerwald, J.E.

    1993-08-01

    The Clean Air Act as amended in 1977 prescribes several technology based limitations affecting new or modified air pollution sources: (1) new source performance stds. (NSPS); (2) best available control technology (BACT); and (3) lowest achievable emission rates (LAER). The basic purposes of the RACT/BACT/LAER Clearinghouse are to: (1) provide State and local air pollution control agencies with current information on case-by-case control technology determinations that are made nationwide and (2) promote communication, cooperation, and sharing of control technology information among the permitting agencies. The information presented in the compilation was abstracted from preconstruction permits and submitted voluntarily by the State and local agencies in making RACT/BACT/LAER decisions.

  2. Conjoined Twins: A Worldwide Collaborative Epidemiological Study of the International Clearinghouse for Birth Defects Surveillance and Research

    PubMed Central

    MUTCHINICK, OSVALDO M.; LUNA-MUÑOZ, LEONORA; AMAR, EMMANUELLE; BAKKER, MARIAN K.; CLEMENTI, MAURIZIO; COCCHI, GUIDO; DUTRA, MARIA DA GRAÇA; FELDKAMP, MARCIA L.; LANDAU, DANIELLE; LEONCINI, EMANUELE; LI, ZHU; LOWRY, BRIAN; MARENGO, LISA K.; MARTÍNEZ-FRÍAS, MARÍA-LUISA; MASTROIACOVO, PIERPAOLO; MÉTNEKI, JULIA; MORGAN, MARGERY; PIERINI, ANNA; RISSMAN, ANKE; RITVANEN, ANNUKKA; SCARANO, GIOACCHINO; SIFFEL, CSABA; SZABOVA, ELENA; ARTEAGA-VÁZQUEZ, JAZMÍN

    2015-01-01

    Conjoined twins (CT) are a very rare developmental accident of uncertain etiology. Prevalence has been previously estimated to be 1 in 50,000 to 1 in 100,000 births. The process by which monozygotic twins do not fully separate but form CT is not well understood. The purpose of the present study was to analyze diverse epidemiological aspects of CT, including the different variables listed in the Introduction Section of this issue of the Journal. The study was made possible using the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR) structure. This multicenter worldwide research includes the largest sample of CT ever studied. A total of 383 carefully reviewed sets of CT obtained from 26,138,837 births reported by 21 Clearinghouse Surveillance Programs (SP) were included in the analysis. Total prevalence was 1.47 per 100,000 births (95% CI: 1.32–1.62). Salient findings including an evident variation in prevalence among SPs: a marked variation in the type of pregnancy outcome, a similarity in the proportion of CT types among programs: a significant female predominance in CT: particularly of the thoracopagus type and a significant male predominance in parapagus and parasitic types: significant differences in prevalence by ethnicity and an apparent increasing prevalence trend in South American countries. No genetic, environmental or demographic significant associated factors were identified. Further work in epidemiology and molecular research is necessary to understand the etiology and pathogenesis involved in the development of this fascinating phenomenon of nature. PMID:22002822

  3. A European perspective--the European clinical research infrastructures network.

    PubMed

    Demotes-Mainard, J; Kubiak, C

    2011-11-01

    Evaluating research outcomes requires multinational cooperation in clinical research for optimization of treatment strategies and comparative effectiveness research, leading to evidence-based practice and healthcare cost containment. The European Clinical Research Infrastructures Network (ECRIN) is a distributed ESFRI (European Strategy Forum on Research Infrastructures) roadmap pan-European infrastructure designed to support multinational clinical research, making Europe a single area for clinical studies, taking advantage of its population size to access patients, and unlocking latent scientific potential. Servicing multinational trials started during its preparatory phase, and ECRIN will now apply for an ERIC (European Research Infrastructures Consortium) status by 2011. By creating a single area for clinical research in Europe, this achievement will contribute to the implementation of the Europe flagship initiative 2020 'Innovation Union', whose objectives include defragmentation of the research and education capacity, tackling the major societal challenges starting with the area of healthy ageing, and removing barriers to bring ideas to the market.

  4. The Danish contribution to the European DEMOCOPHES project: A description of cadmium, cotinine and mercury levels in Danish mother-child pairs and the perspectives of supplementary sampling and measurements.

    PubMed

    Mørck, Thit A; Nielsen, Flemming; Nielsen, Jeanette K S; Jensen, Janne F; Hansen, Pernille W; Hansen, Anne K; Christoffersen, Lea N; Siersma, Volkert D; Larsen, Ida H; Hohlmann, Linette K; Skaanild, Mette T; Frederiksen, Hanne; Biot, Pierre; Casteleyn, Ludwine; Kolossa-Gehring, Marike; Schwedler, Gerda; Castaño, Argelia; Angerer, Jürgen; Koch, Holger M; Esteban, Marta; Schoeters, Greet; Den Hond, Elly; Exley, Karen; Sepai, Ovnair; Bloemen, Louis; Joas, Reinhard; Joas, Anke; Fiddicke, Ulrike; Lopez, Ana; Cañas, Ana; Aerts, Dominique; Knudsen, Lisbeth E

    2015-08-01

    Human biomonitoring (HBM) is an important tool, increasingly used for measuring true levels of the body burdens of environmental chemicals in the general population. In Europe, a harmonized HBM program was needed to open the possibility to compare levels across borders. To explore the prospect of a harmonized European HBM project, DEMOCOPHES (DEMOnstration of a study to COordinate and Perform Human biomonitoring on a European Scale) was completed in 17 European countries. The basic measurements performed in all implemented countries of DEMOCOPHES included cadmium, cotinine and phthalate metabolites in urine and mercury in hair. In the Danish participants, significant correlations between mothers and children for mercury in hair and cotinine in urine were found. Mercury in hair was further significantly associated with intake of fish and area of residence. Cadmium was positively associated with BMI in mothers and an association between cadmium and cotinine was also found. As expected high cotinine levels were found in smoking mothers. For both mercury and cadmium significantly higher concentrations were found in the mothers compared to their children. In Denmark, the DEMOCOPHES project was co-financed by the Danish ministries of health, environment and food safety. The co-financing ministries agreed to finance a number of supplementary measurements of substances of current toxicological, public and regulatory interest. This also included blood sampling from the participants. The collected urine and blood samples were analyzed for a range of other persistent and non-persistent environmental chemicals as well as two biomarkers of effect. The variety of supplementary measurements gives the researchers further information on the exposure status of the participants and creates a basis for valuable knowledge on the pattern of exposure to various chemicals.

  5. The Danish contribution to the European DEMOCOPHES project: A description of cadmium, cotinine and mercury levels in Danish mother-child pairs and the perspectives of supplementary sampling and measurements

    SciTech Connect

    Mørck, Thit A.; Nielsen, Flemming; Nielsen, Jeanette K.S.; Jensen, Janne F.; Hansen, Pernille W.; Hansen, Anne K.; Christoffersen, Lea N.; Siersma, Volkert D.; Larsen, Ida H.; Hohlmann, Linette K.; Skaanild, Mette T.; Frederiksen, Hanne; Biot, Pierre; Casteleyn, Ludwine; Kolossa-Gehring, Marike; Schwedler, Gerda; Castaño, Argelia; Angerer, Jürgen; Koch, Holger M.; Esteban, Marta; and others

    2015-08-15

    Human biomonitoring (HBM) is an important tool, increasingly used for measuring true levels of the body burdens of environmental chemicals in the general population. In Europe, a harmonized HBM program was needed to open the possibility to compare levels across borders. To explore the prospect of a harmonized European HBM project, DEMOCOPHES (DEMOnstration of a study to COordinate and Perform Human biomonitoring on a European Scale) was completed in 17 European countries. The basic measurements performed in all implemented countries of DEMOCOPHES included cadmium, cotinine and phthalate metabolites in urine and mercury in hair. In the Danish participants, significant correlations between mothers and children for mercury in hair and cotinine in urine were found. Mercury in hair was further significantly associated with intake of fish and area of residence. Cadmium was positively associated with BMI in mothers and an association between cadmium and cotinine was also found. As expected high cotinine levels were found in smoking mothers. For both mercury and cadmium significantly higher concentrations were found in the mothers compared to their children. In Denmark, the DEMOCOPHES project was co-financed by the Danish ministries of health, environment and food safety. The co-financing ministries agreed to finance a number of supplementary measurements of substances of current toxicological, public and regulatory interest. This also included blood sampling from the participants. The collected urine and blood samples were analyzed for a range of other persistent and non-persistent environmental chemicals as well as two biomarkers of effect. The variety of supplementary measurements gives the researchers further information on the exposure status of the participants and creates a basis for valuable knowledge on the pattern of exposure to various chemicals. - Highlights: • Levels of cadmium, mercury and cotinine in the Danish subpopulation are comparable to levels in the

  6. The European NEO Coordination Centre

    NASA Astrophysics Data System (ADS)

    Perozzi, E.; Borgia, B.; Micheli, M.

    An operational approach to NEO (Near-Earth Object) hazard monitoring has been developed at European level within the framework of the Space Situational Awareness Program (SSA) of the European Space Agency (ESA). Through federating European assets and profiting of the expertise developed in European Universities and Research Centers, it has been possible to start the deployment of the so-called SSA NEO Segment. This initiative aims to provide a significant contribution to the worldwide effort to the discovery, follow-up and characterization of the near-Earth object population. A major achievement has been the inauguration in May 2013 of the ESA NEO Coordination Centre located at ESRIN (Frascati, Italy). The goal of the NEOCC Precursor Service operations is twofold: to make available updated information on the NEO population and the associated hazard and to contribute to optimize the NEO observational efforts. This is done by maintaining and improving a Web Portal publicly available at http://neo.ssa.esa.int and by performing follow-up observations through a network of collaborating telescopes and facilities. An overview of the SSA-NEO System and a summary of the first two years of NEOCC operations is presented.

  7. The Imprimatur of Europe: Turkey, Europeanization, and the European Union

    DTIC Science & Technology

    1994-08-01

    barriers to Turkey’s admission to the ED, the EU’s position on Turkey’s accession, bilateral views of key EU members, and assessment of the likelihood of...circumstances found in the international system. Our purpose is to look carefully at each view with an eye towards assessing its relative ability to contribute...intergovernmental organizations like OPEC, the United Nations, and the European Union, as well as multinational corporations like IBM, Shell or Ford, and

  8. Trends in Technology Transfer at Universities. Report of the Clearinghouse on University-Industry Relations.

    ERIC Educational Resources Information Center

    Association of American Universities, Washington, DC.

    Trends in university technology transfer activities and the commercialization of research results are discussed, based on a 1985 survey. Responses revealed widespread changes in internal patent and licensing activities and increased disclosure of inventions by faculty to the university. Factors contributing to this trend include: changes in…

  9. Recent Activities against Citizens and Residents of Asian Descent. Clearinghouse Publication No. 88.

    ERIC Educational Resources Information Center

    Commission on Civil Rights, Washington, DC.

    This report describes some recent examples of racially motivated conduct directed against Asian Americans, and identifies factors that contribute to them. The report reviews the following sources of information: (1) literature on the topic; (2) hearings by local human rights agencies; (3) data from the Bureau of the Census, the Office of Refugee…

  10. Pursuing the Clearinghouse Goal: Report of the National Indian Policy Center for Program Year 1995.

    ERIC Educational Resources Information Center

    National Indian Policy Center, Washington, DC.

    The National Indian Policy Center was established by Congress in 1990 to determine whether an Indian policy research institution could provide Indian tribes, Congress, and federal agencies with information that would contribute to the development of sound Indian policies. The Center is governed by a planning committee of tribal leaders,…

  11. Cyclopia: an epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research.

    PubMed

    Orioli, Iêda M; Amar, Emmanuelle; Bakker, Marian K; Bermejo-Sánchez, Eva; Bianchi, Fabrizio; Canfield, Mark A; Clementi, Maurizio; Correa, Adolfo; Csáky-Szunyogh, Melinda; Feldkamp, Marcia L; Landau, Danielle; Leoncini, Emanuele; Li, Zhu; Lowry, R Brian; Mastroiacovo, Pierpaolo; Morgan, Margery; Mutchinick, Osvaldo M; Rissmann, Anke; Ritvanen, Annukka; Scarano, Gioacchino; Szabova, Elena; Castilla, Eduardo E

    2011-11-15

    Cyclopia is characterized by the presence of a single eye, with varying degrees of doubling of the intrinsic ocular structures, located in the middle of the face. It is the severest facial expression of the holoprosencephaly (HPE) spectrum. This study describes the prevalence, associated malformations, and maternal characteristics among cases with cyclopia. Data originated in 20 Clearinghouse (ICBDSR) affiliated birth defect surveillance systems, reported according to a single pre-established protocol. A total of 257 infants with cyclopia were identified. Overall prevalence was 1 in 100,000 births (95%CI: 0.89-1.14), with only one program being out of range. Across sites, there was no correlation between cyclopia prevalence and number of births (r = 0.08; P = 0.75) or proportion of elective termination of pregnancy (r = -0.01; P = 0.97). The higher prevalence of cyclopia among older mothers (older than 34) was not statistically significant. The majority of cases were liveborn (122/200; 61%) and females predominated (male/total: 42%). A substantial proportion of cyclopias (31%) were caused by chromosomal anomalies, mainly trisomy 13. Another 31% of the cases of cyclopias were associated with defects not typically related to HPE, with more hydrocephalus, heterotaxia defects, neural tube defects, and preaxial reduction defects than the chromosomal group, suggesting the presence of ciliopathies or other unrecognized syndromes. Cyclopia is a very rare defect without much variability in prevalence by geographic location. The heterogeneous etiology with a high prevalence of chromosomal abnormalities, and female predominance in HPE, were confirmed, but no effect of increased maternal age or association with twinning was observed.

  12. Cyclopia: An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research

    PubMed Central

    Orioli, Iêda M.; Amar, Emmanuelle; Bakker, Marian K.; Bermejo-Sánchez, Eva; Bianchi, Fabrizio; Canfield, Mark A.; Clementi, Maurizio; Correa, Adolfo; Csáky-Szunyogh, Melinda; Feldkamp, Marcia L.; Landau, Danielle; Leoncini, Emanuele; Li, Zhu; Lowry, R. Brian; Mastroiacovo, Pierpaolo; Morgan, Margery; Mutchinick, Osvaldo M.; Rissmann, Anke; Ritvanen, Annukka; Scarano, Gioacchino; Szabova, Elena; Castilla, Eduardo E.

    2015-01-01

    Cyclopia is characterized by the presence of a single eye, with varying degrees of doubling of the intrinsic ocular structures, located in the middle of the face. It is the severest facial expression of the holoprosencephaly (HPE) spectrum. This study describes the prevalence, associated malformations, and maternal characteristics among cases with cyclopia. Data originated in 20 Clearinghouse (ICBDSR) affiliated birth defect surveillance systems, reported according to a single pre-established protocol. A total of 257 infants with cyclopia were identified. Overall prevalence was 1 in 100,000 births (95%CI: 0.89–1.14), with only one program being out of range. Across sites, there was no correlation between cyclopia prevalence and number of births (r = 0.08; P=0.75) or proportion of elective termination of pregnancy (r= −0.01; P=0.97). The higher prevalence of cyclopia among older mothers (older than 34) was not statistically significant. The majority of cases were liveborn (122/200; 61%) and females predominated (male/total: 42%). A substantial proportion of cyclopias (31%) were caused by chromosomal anomalies, mainly trisomy 13. Another 31% of the cases of cyclopias were associated with defects not typically related to HPE, with more hydrocephalus, heterotaxia defects, neural tube defects, and preaxial reduction defects than the chromosomal group, suggesting the presence of ciliopathies or other unrecognized syndromes. Cyclopia is a very rare defect without much variability in prevalence by geographic location. The heterogeneous etiology with a high prevalence of chromosomal abnormalities, and female predominance in HPE, were confirmed, but no effect of increased maternal age or association with twinning was observed. PMID:22006661

  13. Professional Learning Communities Participant's Activities for the What Works Clearinghouse Practice Guide: Foundational Skills to Support Reading for Understanding in Kindergarten through 3rd Grade. REL 2016-277a

    ERIC Educational Resources Information Center

    Kosanovich, Marcia; Foorman, Barbara

    2016-01-01

    The Regional Educational Laboratory (REL) Southeast developed a Professional Learning Community (PLC) Facilitators Guide to support educators in the implementation of recommendations from the What Works Clearinghouse's. The practice guide focuses on the foundational reading skills that enable students to read words, relate those words to their…

  14. Professional Learning Communities Facilitator's Guide for the What Works Clearinghouse Practice Guide: Foundational Skills to Support Reading for Understanding in Kindergarten through 3rd Grade. REL 2016-277

    ERIC Educational Resources Information Center

    Kosanovich, Marcia; Foorman, Barbara

    2016-01-01

    The Regional Educational Laboratory (REL) Southeast developed a Professional Learning Community (PLC) Facilitators Guide to support educators in the implementation of recommendations from the What Works Clearinghouse's. The practice guide focuses on the foundational reading skills that enable students to read words, relate those words to their…

  15. An overview on European SPS activities

    NASA Technical Reports Server (NTRS)

    Reinhartz, K. K.

    1980-01-01

    The organization of space and energy research in Europe is discussed. The European situation is highlighted with emphasis on the dependency of energy imports and on the energy requirements of Europe. The status of SPS research in the countries that form the European Space Agency was reviewed. It is concluded that in view of the unfavorable geographical and climatic situation of large parts of Europe, terrestrial solar energy conversion is unlikely to make a significant contribution to Europe's future energy supply. Thus, SPS development is of special interest to the European community.

  16. Recycling policy in the european union

    NASA Astrophysics Data System (ADS)

    Gaballah, I.; Kanari, N.

    2001-11-01

    Recycling in the European Union (EU) has benefited from R&D efforts and strict environmental regulations of the EU’s members. Thanks to the adoption of sustainable development policies by the EU’s European Institutions, economic incentives are expected to further strengthen the recycling industry. Moreover, the historical accumulation of non-ferrous metals in Europe will likely enhance secondary metal production. Also contributing to EU recycling is mining in East European countries and the resulting industrial waste. The rate of growth of the recycling industry is expected to approach double digits for at least this decade.

  17. European biofuel plan snagged

    SciTech Connect

    Chynoweth, E.

    1992-12-16

    European Commission proposals for a directive aimed at boosting production of biofuels have been set back by the European Parliament and will not be implemented on the January 1, 1993 deadline. Furthermore, the commission has agreed to carry out an environmental impact study on biofuels. European industrial ethanol, fatty acid, and glycerin producers oppose the directive proposals fearing distortions in their markets.

  18. European Elder (Elderberry)

    MedlinePlus

    ... Common Names: European elder, black elder, elderberry, elder flower, sambucus Latin Name: Sambucus nigra Background European elder ... Saxon word “aeld,” meaning fire. The terms “elder flower” and “elderberry” may refer to either European elder ...

  19. The Development of Standards-Based Services Oriented Architectures at EDAC, Lessons Learned From Three Applications Contexts: Environmental Public Health, Hydrologic Modeling and ET Measurement, and a Geospatial Data Clearinghouse

    NASA Astrophysics Data System (ADS)

    Benedict, K. K.

    2008-05-01

    has been developed as a distributed system with separate public health or environmental parameter data providers contributing to the system through a standardized SOAP interface. These data are integrated into a component-based system that uses a collection of SOAP services for functions including authentication, data discovery, tabular data extraction, data fusion for common geographic features, A master workflow SOAP service handles all incoming requests to the system and executes pre-defined processing chains to accomplish the required service calls. In addition to SOAP, the system uses WMS as the standard mapping service interface for the delivery of background data into the mapping client provided as part of the web-based user interface. This component-based SOAP architecture has proven very flexible and robust and represents a useful model for the development of an end-to-end data management, processing, and presentation solution. EDAC maintains the NM Resource Geographic Information System, a clearinghouse for geospatial data for the state of New Mexico. As RGIS evolves towards the next version of the online clearinghouse, SOAP and WMS are key standards that enable data discovery, delivery, and visualization functions. These services have proven quite robust in supporting a system that delivers approximately 1.5-2 TB of data per year to end users.

  20. The European standards of Haemophilia Centres

    PubMed Central

    Giangrande, Paul; Calizzani, Gabriele; Menichini, Ivana; Candura, Fabio; Mannucci, Pier Mannuccio; Makris, Michael

    2014-01-01

    Introduction The European haemophilia community of professionals and patients has agreed on the principles of haemophilia care to address comprehensive optimal delivery of care which is nowadays scattered throughout Europe. Many of the health facilities call themselves Haemophilia Centres despite their variation in size, expertise and services provided. Only a small number of countries have Haemophilia Centre accreditation systems in place. Methods In the framework of the European Haemophilia Network project, following an inclusive process of stakeholder involvement, the European Guidelines for the certification of haemophilia centres have been developed in order to set quality standards for European Haemophilia Centres and criteria for their certification. Results The Guidelines define the standards and criteria for the designation of two levels of care delivery: European Haemophilia Treatment Centres, providing local routine care, and European Haemophilia Comprehensive Care Centres, providing specialised and multi-disciplinary care and functioning as tertiary referral centres. Additionally, they define standards about general requirements, patient care, provision of an advisory service and establishment of network of clinical and specialised services. Conclusions The implementation of the European Guidelines for the certification of Haemophilia Centres will contribute to the reduction of health inequalities through the standardisation of quality of care in European Union Member States and could represent a model to be taken into consideration for other rare disease groups. PMID:24922293

  1. The contribution of risk factors to the higher incidence of invasive and in situ breast cancers in women with higher levels of education in the European prospective investigation into cancer and nutrition.

    PubMed

    Menvielle, Gwenn; Kunst, Anton E; van Gils, Carla H; Peeters, Petra H; Boshuizen, Hendriek; Overvad, Kim; Olsen, Anja; Tjonneland, Anne; Hermann, Silke; Kaaks, Rudolf; Bergmann, Manuela M; Illner, Anne-Kathrin; Lagiou, Pagona; Trichopoulos, Dimitrios; Trichopoulou, Antonia; Palli, Domenico; Berrino, Franco; Mattiello, Amelia; Tumino, Rosario; Sacerdote, Carlotta; May, Anne; Monninkhof, Evelyn; Braaten, Tonje; Lund, Eiliv; Quirós, José Ramón; Duell, Eric J; Sánchez, Maria-José; Navarro, Carmen; Ardanaz, Eva; Borgquist, Signe; Manjer, Jonas; Khaw, Kay Tee; Allen, Naomi E; Reeves, Gillian K; Chajes, Véronique; Rinaldi, Sabina; Slimani, Nadia; Gallo, Valentina; Vineis, Paolo; Riboli, Elio; Bueno-de-Mesquita, H Bas

    2011-01-01

    The authors investigated the role of known risk factors in educational differences in breast cancer incidence. Analyses were based on the European Prospective Investigation Into Cancer and Nutrition and included 242,095 women, 433 cases of in situ breast cancer, and 4,469 cases of invasive breast cancer. Reproductive history (age at first full-term pregnancy and parity), exposure to endogenous and exogenous hormones, height, and health behaviors were accounted for in the analyses. Relative indices of inequality (RII) for education were estimated using Cox regression models. A higher risk of invasive breast cancer was found among women with higher levels of education (RII = 1.22, 95% confidence interval (CI): 1.09, 1.37). This association was not observed among nulliparous women (RII = 1.13, 95% CI: 0.84, 1.52). Inequalities in breast cancer incidence decreased substantially after adjusting for reproductive history (RII = 1.11, 95% CI: 0.98, 1.25), with most of the association being explained by age at first full-term pregnancy. Each other risk factor explained a small additional part of the inequalities in breast cancer incidence. Height accounted for most of the remaining differences in incidence. After adjusting for all known risk factors, the authors found no association between education level and risk of invasive breast cancer. Inequalities in incidence were more pronounced for in situ breast cancer, and those inequalities remained after adjustment for all known risk factors (RII = 1.61, 95% CI: 1.07, 2.41), especially among nulliparous women.

  2. Cost-benefit assessment of using electronic health records data for clinical research versus current practices: Contribution of the Electronic Health Records for Clinical Research (EHR4CR) European Project.

    PubMed

    Beresniak, Ariel; Schmidt, Andreas; Proeve, Johann; Bolanos, Elena; Patel, Neelam; Ammour, Nadir; Sundgren, Mats; Ericson, Mats; Karakoyun, Töresin; Coorevits, Pascal; Kalra, Dipak; De Moor, Georges; Dupont, Danielle

    2016-01-01

    The widespread adoption of electronic health records (EHR) provides a new opportunity to improve the efficiency of clinical research. The European EHR4CR (Electronic Health Records for Clinical Research) 4-year project has developed an innovative technological platform to enable the re-use of EHR data for clinical research. The objective of this cost-benefit assessment (CBA) is to assess the value of EHR4CR solutions compared to current practices, from the perspective of sponsors of clinical trials. A CBA model was developed using an advanced modeling approach. The costs of performing three clinical research scenarios (S) applied to a hypothetical Phase II or III oncology clinical trial workflow (reference case) were estimated under current and EHR4CR conditions, namely protocol feasibility assessment (S1), patient identification for recruitment (S2), and clinical study execution (S3). The potential benefits were calculated considering that the estimated reduction in actual person-time and costs for performing EHR4CR S1, S2, and S3 would accelerate time to market (TTM). Probabilistic sensitivity analyses using Monte Carlo simulations were conducted to manage uncertainty. Should the estimated efficiency gains achieved with the EHR4CR platform translate into faster TTM, the expected benefits for the global pharmaceutical oncology sector were estimated at €161.5m (S1), €45.7m (S2), €204.5m (S1+S2), €1906m (S3), and up to €2121.8m (S1+S2+S3) when the scenarios were used sequentially. The results suggest that optimizing clinical trial design and execution with the EHR4CR platform would generate substantial added value for pharmaceutical industry, as main sponsors of clinical trials in Europe, and beyond. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Supporting Enterprise. A College Contribution.

    ERIC Educational Resources Information Center

    Bolton, John F.; Cook, David

    This report describes the experience of one college--Percival Whitley College in Calderdale, England--in contributing to the strategy for economic regeneration of the surrounding metropolitan district. It charts the success of the borough and the college working together to attract national and European funding. A checklist for implementing…

  4. Supporting Enterprise. A College Contribution.

    ERIC Educational Resources Information Center

    Bolton, John F.; Cook, David

    This report describes the experience of one college--Percival Whitley College in Calderdale, England--in contributing to the strategy for economic regeneration of the surrounding metropolitan district. It charts the success of the borough and the college working together to attract national and European funding. A checklist for implementing…

  5. The European Location Framework - from National to European

    NASA Astrophysics Data System (ADS)

    Pauknerova, E.; Sidlichovsky, P.; Urbanas, S.; Med, M.

    2016-06-01

    EuroGeographics - their pan-European umbrella association, contribute to the ELF through an enrichment of data coverage. As a result, over 20 European countries will be covered with the ELF topo Base Map in 2016. Most countries will contribute also with other harmonized thematic data for viewing or down-loading. To overcome the heterogeneity of data resources and diversity of languages in tens of European countries, ELF builds on the existing INSPIRE rules and its own coordination and interoperability measures. ELF realisation empowers the implementation of INSPIRE in Europe and it complements related activities of European NMCAs, e.g. Czech Office for Surveying, Mapping and Cadastre (CUZK), which provides a large portfolio of spatial data/services and contributes significantly to the NSDI of Czech Republic. CUZK is also responsible for the Base Register of Territorial Identification, Addresses and Real Estates (RUIAN) - an important pillar of Czech e-Government. CUZK became an early-bird in implementing INSPIRE and it provides to the ELF a number of compliant datasets and web services. CUZK and the Polish NMCA (GUGiK) collaborate in the Central-European ELF Pilot (cluster) and test various cross-border prototypes. The presentation combines the national and crossborder view and experiences of CUZK and the European perspective of EuroGeographics.

  6. Training and mobility: a priority for the Organisation of the European Cancer Institutes. How a national mobility initiative could enhance EU cooperation in cancer research contributing to the development of an European Research Area: the example of The Italian Comprehensive Cancer Centers' Network "Alleanza Contro il Cancro".

    PubMed

    Lombardo, Claudio; Albanese, Daniela; Belardelli, Filippo; d'Alessandro, Francesca; Giacomini, Mauro; Rondanina, Tania; Spagnoli, Luigi G

    2008-01-01

    It is widely recognized that productivity gains, sustained economic growth and employment are largely determined by technological progress, innovation and human capital. The 2000 Lisbon strategy to make Europe a competitive knowledge-based economy by 2010 and, more specifically, the Barcelona objectives agreed upon in 2002 to increase R&D investment in the EU to approach 3% of GDP, ensuring that there are sufficient human resources for research, are a preliminary step in this direction. If we want to reach this goal we have to succeed in retaining the best researchers, creating the right environment where they can perform their activities and develop their careers. To this aim the Organization of European Cancer Institutes (OECI) has set up a working group on Education and Training with the mandate to encourage continuing education in cancer research and applications and to verify the feasibility to promote mobility programs inside the network and in association with industries. Until now only few OECI training programs have been launched and a full mobility program has not been developed yet due to limited budget resources. The Italian Network of Comprehensive Cancer Centers, Alleanza Contro il Cancro, has planned the launch of a mobility program awarding 70 annual fellowships over a period of 36 months. This program, which will be open to the world research community, could represent a first interaction through mobility among the members of the OECI network also involving industries. The program is a tangible approach to sustain the translational process needed for the development of an European Research Area in the field of cancer and its related biomedical disciplines, thus providing a practical answer to the 2005 renewed Lisbon Strategy.

  7. VIROTHERAPY RESEARCH IN GERMANY - FROM ENGINEERING TO TRANSLATION A Review as contribution to the Combined Annual Meeting of the German and European Societies of Gene (and Cell) Therapy 2017.

    PubMed

    Ungerechts, Guy; Engeland, Christine E; Buchholz, Christian J; Eberle, Jürgen; Fechner, Henry; Geletneky, Karsten; Holm, Per Sonne; Kreppel, Florian; Kühnel, Florian; Lang, Karl Sebastian; Leber, Mathias F; Marchini, Antonio; Moehler, Markus; Mühlebach, Michael D; Rommelaere, Jean; Springfeld, Christoph; Lauer, Ulrich M; Nettelbeck, Dirk M

    2017-09-04

    Virotherapy is a unique modality for treatment of cancer with oncolytic viruses (OVs) that selectively infect and lyse tumor cells, spread within tumors, and activate anti-tumor immunity. Different viruses are being developed as OVs preclinically and clinically, several of them engineered to encode therapeutic proteins for tumor-targeted gene therapy. Scientists and clinicians in Germany have made significant contributions to OV research and development, which are highlighted in this review article. Innovative strategies for "shielding", entry- or post-entry targeting, and "arming" of OVs have been established focusing on adeno-, measles, parvo-, and vaccinia virus platforms. Thereby, new generation virotherapeutics have been derived. Moreover, immunotherapeutic properties of OVs and combination therapies with pharmaco-, radio- and especially immunotherapy have been investigated and optimized. German investigators are increasingly assessing their OV innovations in investigator-initiated and sponsored clinical trials. As prototype, parvovirus has been tested as OV from preclinical proof-of-concept up to first-in-man clinical studies. The approval of the first OV in the western world, T-VEC (Imlygic TM), has further spurred involvement of investigators in Germany in international multicenter studies. With the recent encouraging developments in funding, commercialization and regulatory procedures, more German engineering will be translated into OV clinical trials in the near future.

  8. [Biobanks European infrastructure].

    PubMed

    Kinkorová, Judita; Topolčan, Ondřej

    2016-01-01

    Biobanks are structured repositories of human tissue samples connected with specific information. They became an integral part of personalized medicine in the new millennium. At the European research area biobanks are isolated not well coordinated and connected to the network. European commission supports European infrastructure BBMRI-ERIC (Biobanks and Biomolecular Resources Research Infrastructure European Research Infrastructure Consortium), consortium of 54 members with more than 225 associated organizations, largely biobanks from over 30 countries. The aim is to support biomedical research using stored samples. Czech Republic is a member of the consortium as a national node BBMRI_CZ, consisting of five partners.

  9. Discerning the Ancestry of European Americans in Genetic Association Studies

    PubMed Central

    Price, Alkes L; Butler, Johannah; Patterson, Nick; Capelli, Cristian; Pascali, Vincenzo L; Scarnicci, Francesca; Ruiz-Linares, Andres; Groop, Leif; Saetta, Angelica A; Korkolopoulou, Penelope; Seligsohn, Uri; Waliszewska, Alicja; Schirmer, Christine; Ardlie, Kristin; Ramos, Alexis; Nemesh, James; Arbeitman, Lori; Goldstein, David B

    2008-01-01

    European Americans are often treated as a homogeneous group, but in fact form a structured population due to historical immigration of diverse source populations. Discerning the ancestry of European Americans genotyped in association studies is important in order to prevent false-positive or false-negative associations due to population stratification and to identify genetic variants whose contribution to disease risk differs across European ancestries. Here, we investigate empirical patterns of population structure in European Americans, analyzing 4,198 samples from four genome-wide association studies to show that components roughly corresponding to northwest European, southeast European, and Ashkenazi Jewish ancestry are the main sources of European American population structure. Building on this insight, we constructed a panel of 300 validated markers that are highly informative for distinguishing these ancestries. We demonstrate that this panel of markers can be used to correct for stratification in association studies that do not generate dense genotype data. PMID:18208327

  10. Alignment of single-case design (SCD) research with individuals who are deaf or hard of hearing with the what Works Clearinghouse standards for SCD research.

    PubMed

    Wendel, Erica; Cawthon, Stephanie W; Ge, Jin Jin; Beretvas, S Natasha

    2015-04-01

    The authors assessed the quality of single-case design (SCD) studies that assess the impact of interventions on outcomes for individuals who are deaf or hard-of-hearing (DHH). More specifically, the What Works Clearinghouse (WWC) standards for SCD research were used to assess design quality and the strength of evidence of peer-reviewed studies available in the peer-reviewed, published literature. The analysis yielded four studies that met the WWC standards for design quality, of which two demonstrated moderate to strong evidence for efficacy of the studied intervention. Results of this review are discussed in light of the benefits and the challenges to applying the WWC design standards to research with DHH individuals and other diverse, low-incidence populations.

  11. European Scientific Notes. Volume 28, Number 12,

    DTIC Science & Technology

    The monthly publication presents articles about recent developments in European scientific research. Although this information is not a contribution to the scientific literature, it is intended to aid American scientists by reporting events and results well in advance of most of the scientific publications and the trade journals.

  12. European Flagship Universities: Autonomy and Change

    ERIC Educational Resources Information Center

    Gornitzka, Åse; Maassen, Peter

    2017-01-01

    The article introduces this special issue of Higher Education Quarterly in which results of a research project on "European Flagship Universities: Balancing Academic Excellence and Socio-economic Relevance" are presented and discussed. The Flagship project aimed at contributing to a better understanding of the relationship between…

  13. Orchestrating French Music Conservatories: European Political Interventions and Local Governance

    ERIC Educational Resources Information Center

    Raevskikh, Elena

    2017-01-01

    Supported by the omnipresent State in the past, French music education leans increasingly towards a more liberal and competitive model. In the current context of a decentralized economy and European integration, music conservatories are called upon to contribute to regional and municipal development and enhance European student mobility. How do…

  14. European perspective of ecosystem services and related policies.

    PubMed

    Dunbar, Martha Bonnet; Panagos, Panos; Montanarella, Luca

    2013-04-01

    In this article, we focus on the importance of terrestrial ecosystems and the services they provide. European Union policies, contributing to the conservation and maintenance of ecosystem services in Europe are discussed and their current impacts briefly reviewed in the light of the main challenges that European ecosystems might face in the near future.

  15. Barriers Impact U.S. Marketing to the European Community.

    ERIC Educational Resources Information Center

    Metzger, Leila

    For a quarter of a century, the United States has been gradually losing market share in the European Community, which accounts for about one-fifth of world trade. The European Community consumes about one-fourth of United States exports, but this represents only about eight percent of its total imports. Three of the barriers contributing to…

  16. European auxiliary propulsion, 1972

    NASA Technical Reports Server (NTRS)

    Holcomb, L. B.

    1972-01-01

    The chemical and electric auxiliary propulsion technology of the United Kingdom, France, and West Germany is discussed in detail, and the propulsion technology achievements of Italy, India, Japan, and Russia are reviewed. A comparison is presented of Shell 405 catalyst and a European spontaneous hydrazine catalyst called CNESRO I. Finally, conclusions are drawn regarding future trends in European auxiliary propulsion technology development.

  17. Regional Development and the European Consortium of Innovative Universities.

    ERIC Educational Resources Information Center

    Hansen, Saskia Loer; Kokkeler, Ben; van der Sijde, P. C.

    2002-01-01

    The European Consortium of Innovative Universities is a network that shares information not just among universities but with affiliated incubators, research parks, and other regional entities. The learning network contributes to regional development.(JOW)

  18. Acid rain information clearinghouse

    SciTech Connect

    Not Available

    1986-11-01

    Twenty-one research institutions, environmental organizations, trade associations and government agencies from the United States and Canada are co-sponsoring Acid Rain: The Relationship Between Sources and Receptors, a conference to be held December 3-4, 1986 at the Sheraton National Hotel in Arlington, Virginia. The conference, designed for a nontechnical audience as well as specialists in acid rain research, will cover the nature and scope of scientific understanding and research programs, identify areas of consensus and disagreement, and assess policy options in the light of current understanding. A special session on December 3 will address the legal aspects of source-receptor relationships.

  19. SUPERFUND TREATABILITY CLEARINGHOUSE ...

    EPA Pesticide Factsheets

    This newsletter reports on the Huber Technology Groups (HTG) high temperature advanced hazardous waste treatment technology capable of very high destruction and removal efficiencies of various hazardous wastes. This newsletter addresses the destruction of PCBs in an EPA certification test of the HTG Advanced Electric Reactor. provide information

  20. Bed Bug Information Clearinghouse

    EPA Pesticide Factsheets

    Its purpose is to help states, communities, and consumers in efforts to prevent and control bed bug infestations. Currently includes only reviewed material from federal/state/local government agencies, extension services, and universities.

  1. SUPERFUND TREATABILITY CLEARINGHOUSE: FINAL ...

    EPA Pesticide Factsheets

    During the period of July 8 - July 12, 1985, the Shirco Infrared Systems Portable Pilot Test Unit was in operation at the Times Beach Dioxin Research Facility to demonstrate the capability of Shirco's infrared technology to decontaminate silty soil laden with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at a concentration range of 156 to 306 ppb. Emissions sampling and final analysis was performed by Environmental Research & Technology, Inc. (ERT), while laboratory analysis of the emissions and soil samples was performed by Roy F. Weston Inc. Shirco Infrared Systems prepared the testing procedure protocol and operated the furnace system. publish information

  2. SUPERFUND TREATABILITY CLEARINGHOUSE: FULL ...

    EPA Pesticide Factsheets

    This treatability study reports on the results of one of a series of field trials using various remedial action technologies that may be capable of restoring Herbicide Orange (HO)XDioxin contaminated sites. A full-scale field trial using a rotary kiln incinerator capable of processing up to 6 tons per hour of dioxin contaminated soil was conducted at the Naval Construction Battalion Center, Gulfport, MS. publish information

  3. The European Spallation Source

    SciTech Connect

    Lindroos M.; Calaga R.; Bousson S.; Danared H.; Devanz G. et al

    2011-04-20

    In 2003 the joint European effort to design a European Spallation Source (ESS) resulted in a set of reports, and in May 2009 Lund was agreed to be the ESS site. The ESS Scandinavia office has since then worked on setting all the necessary legal and organizational matters in place so that the Design Update and construction can be started in January 2011, in collaboration with European partners. The Design Update phase is expected to end in 2012, to be followed by a construction phase, with first neutrons expected in 2018-2019.

  4. European journals on microbiology.

    PubMed

    Ronda, C; Vázquez, M

    1997-12-01

    A survey on the scientific journals dealing with microbiology published in Europe has been carried out. Eighteen European countries publish microbiological journals with the United Kingdom. Netherlands and Germany leading in number of journals on this specialty. Most of the European journals on microbiology are published bimonthly (27%), and English is the most common language used (54%). Most of these journals (86%) are included in some database, but only 36 (25%) are indexed in the six databases studied. Out of the 146 journals registered, 71 (49%), published in 11 European countries, are included in the 1995 Journal Citation Reports (ISI, Philadelphia).

  5. The European experience.

    PubMed

    Roels, Leo; Rahmel, Axel

    2011-04-01

    This mini-review on European experiences with tackling the problem of organ shortage for transplantation was based on a literature review of predominantly European publications dealing with the issue of organ donation from deceased donors. The authors tried to identify the most significant factors that have demonstrated to impact on donation rates from deceased donors and subsequent transplant successes. These factors include legislative measures (national laws and European Directives), optimization of the donation process, use of expanded criteria donors, innovative preservation and surgical techniques, organizational efforts, and improved allocation algorithms.

  6. European scientific notes. Volume 34, Number 9

    SciTech Connect

    Burt, W.V.; Peters, D.J.

    1980-09-30

    This is a monthly publication presenting brief articles concerning recent developments in European Scientific Research. It is hoped that these articles (which do not constitute part of the scientific literature) may prove of value to American scientists by calling attention to current development and to institutions and individuals engaged in these scientific efforts. The articles are written primarily by members of the staff of ORNL and occasionally articles are prepared by, or in cooperation with, members of the scientific staffs of the United States Air Force's European Office of Aerospace Research and Development and the United States ARmy Research and Standardization Group. Articles are also contributed by visiting Stateside scientists.

  7. Status of German European exhaust emission legislation

    SciTech Connect

    Seiffert, U.

    1985-01-01

    Recent legislative initiatives in West Germany and other European countries are leading to more stringent automobile exhaust emission standards. A review of the emission inventory on a global and West German basis and other factors, such as acid rain and forest damage, indicate that the contribution of automobile exhaust to the emission problem may be less than the European public assumes. As an interim step while new standards are being considered, the West German government is promoting the purchase of low-pollution vehicles through a vehicle tax reduction program.

  8. Astro-H: science goals, development status, and European contribution

    NASA Astrophysics Data System (ADS)

    Sanchez-Fernandez, C.

    2015-07-01

    The joint JAXA/NASA ASTRO-H mission is the sixth X-ray mission initiated by the Institute of Space and Astronautical Science (ISAS). ASTRO-H allows a combination of wide band X-ray spectroscopy (5-80 keV) provided by multilayer coating, focusing hard X-ray mirrors and hard X-ray imaging detectors, and high energy-resolution soft X-ray spectroscopy (0.3-12 keV) provided by thin-foil X-ray optics and a micro-calorimeter array. The mission will also carry a X-ray CCD camera as a focal plane detector for a soft X-ray telescope (0.4-12 keV) and a non-focusing soft gamma-ray detector (40-600 keV). ASTRO-H is expected to provide breakthrough results in the studies of the large-scale structure of the Universe and its evolution, the behaviour of matter in the strong gravitational field regime, providing time-resolved spectra from material approaching the event horizon of a black hole, the physical conditions in sites of cosmic-ray acceleration, and the distribution of dark matter in galaxy clusters at different redshifts. ASTRO-H will be launched into low-Earth orbit from the Tanegashima Space Center, Japan, by a JAXA H-IIA rocket.

  9. European Stroke Science Workshop

    PubMed Central

    Mattle, Heinrich P.; Brainin, Michael; Chamorro, Angel; Diener, Hans Christoph; Hacke, Werner; Leys, Didier; Norrving, Bo; Ward, Nick

    2012-01-01

    The European Stroke Organisation (ESO) held its first European Stroke Science Workshop in Garmisch-Partenkirchen, Germany (15-17 December 2011). Stroke experts based in Europe were invited to present and discuss their current research. The scope of the workshop was to review the most recent findings of selected topics in stroke, to exchange ideas, to stimulate new research and to enhance collaboration between European stroke research groups. Seven scientific sessions were held, each starting with a keynote lecture to review the state of the art of the given topic, followed by 4 or 5 short presentations by experts. They were asked to limit their presentations to 10 slides containing only recent information. The meeting was organized by the executive committee of the ESO (Heinrich Mattle, chairman, Michael Brainin, Angel Chamorro, Werner Hacke, Didier Leys) and supported by the European Stroke Conference (Michael Hennerici). In this article we summarize the main contents of this successful workshop. PMID:22836350

  10. European PTTI report

    NASA Technical Reports Server (NTRS)

    Cordara, Franco; Grimaldi, Sabrina; Leschiutta, Sigfrido

    1994-01-01

    Time and frequency metrology in Europe presents some peculiar features in its three main components: research on clocks, comparisons and dissemination methods, and dissemination services. Apart from the usual activities of the national metrological laboratories, an increasing number of cooperation between the European countries are promoted inside some European organizations, such as the ECC, EFTA, EUROMET, and WECC. Cooperation between these organizations is covered. The present, evolving situation will be further influenced by the recent political changes in Eastern Europe.

  11. European Flood Awareness System - now operational

    NASA Astrophysics Data System (ADS)

    Alionte Eklund, Cristina.; Hazlinger, Michal; Sprokkereef, Eric; Garcia Padilla, Mercedes; Garcia, Rafael J.; Thielen, Jutta; Salamon, Peter; Pappenberger, Florian

    2013-04-01

    The European Commission's Communication "Towards a Stronger European Union Disaster Response" adopted and endorsed by the Council in 2010, underpins the importance of strengthening concerted actions for natural disasters including floods, which are amongst the costliest natural disasters in the EU. The European Flood Awareness System (EFAS) contributes in the case of major flood events. to better protection of the European Citizen, the environment, property and cultural heritage. The disastrous floods in Elbe and Danube rivers in 2002 confronted the European Commission with non-coherent flood warning information from different sources and of variable quality, complicating planning and organisation of aid. Thus, the Commission initiated the development of a European Flood Awareness System (EFAS) which is now going operational. EFAS has been developed and tested at the Joint Research Centre, the Commission's in house science service, in close collaboration with the National hydrological and meteorological services, European Civil Protection through the Monitoring and Information Centre (MIC) and other research institutes. EFAS provides Pan-European overview maps of flood probabilities up to 10 days in advance as well as detailed forecasts at stations where the National services are providing real time data. More than 30 hydrological services and civil protection services in Europe are part of the EFAS network. Since 2011, EFAS is part of the COPERNICUS Emergency Management Service, (EMS) and is now an operational service since 2012. The Operational EFAS is being executed by several consortia dealing with different operational aspects: • EFAS Hydrological data collection centre —REDIAM and ELIMCO- will be collecting historic and realtime discharge and water levels data in support to EFAS • EFAS Meteorological data collection centre —outsourced but running onsite of JRC Ispra. Will be collecting historic and realtime meteorological data in support to EFAS

  12. Joint Efforts Towards European HF Radar Integration

    NASA Astrophysics Data System (ADS)

    Rubio, A.; Mader, J.; Griffa, A.; Mantovani, C.; Corgnati, L.; Novellino, A.; Schulz-Stellenfleth, J.; Quentin, C.; Wyatt, L.; Ruiz, M. I.; Lorente, P.; Hartnett, M.; Gorringe, P.

    2016-12-01

    During the past two years, significant steps have been made in Europe for achieving the needed accessibility to High Frequency Radar (HFR) data for a pan-European use. Since 2015, EuroGOOS Ocean Observing Task Teams (TT), such as HFR TT, are operational networks of observing platforms. The main goal is on the harmonization of systems requirements, systems design, data quality, improvement and proof of the readiness and standardization of HFR data access and tools. Particular attention is being paid by HFR TT to converge from different projects and programs toward those common objectives. First, JERICO-NEXT (Joint European Research Infrastructure network for Coastal Observatory - Novel European eXpertise for coastal observaTories, H2020 2015 Programme) will contribute on describing the status of the European network, on seeking harmonization through exchange of best practices and standardization, on developing and giving access to quality control procedures and new products, and finally on demonstrating the use of such technology in the general scientific strategy focused by the Coastal Observatory. Then, EMODnet (European Marine Observation and Data Network) Physics started to assemble HF radar metadata and data products within Europe in a uniform way. This long term program is providing a combined array of services and functionalities to users for obtaining free of charge data, meta-data and data products on the physical conditions of European sea basins and oceans. Additionally, the Copernicus Marine Environment Monitoring Service (CMEMS) delivers from 2015 a core information service to any user related to 4 areas of benefits: Maritime Safety, Coastal and Marine Environment, Marine Resources, and Weather, Seasonal Forecasting and Climate activities. INCREASE (Innovation and Networking for the integration of Coastal Radars into EuropeAn marine SErvices - CMEMS Service Evolution 2016) will set the necessary developments towards the integration of existing European

  13. European initiatives to develop information systems in oceanography

    NASA Astrophysics Data System (ADS)

    Le Grand, P.

    2009-04-01

    Various initiatives are currently in preparation or ongoing at the European level to improve information systems in Earth Sciences and oceanographic systems are at the forefront of these efforts. Europe is playing a leading role in the Group on Earth Observation (GEO) that aims to implement the Global Earth Observation System of Systems (GEOSS). The GEO Architecture and Data Committee, oversees the development of the GEOSS Common Infrastructure (GCI) which consists of a web-based portal, a clearinghouse for searching data, information and services, registries containing information about GEOSS components and associated standards and best practices. This development is detailed in the various tasks of the GEO Work Plan . Several European projects in the marine domain funded under the research framework program participate in the development of the GEOSS. EMODNET is another initiative to develop a system that will allow a better identification and access to marine data that are being collected, that will permit the identification of data gaps and that will shape a data collection and monitoring infrastructure directly suited to multiple applications. A number of measures have already been taken at EU level - the INSPIRE Directive obliges Member States to facilitate discovery of data holdings, the Environmental Information Directive requires them to release the data when asked, the Public Sector Information Directive facilitates the re-use of public data and the revised Data Collection Regulation has improved the availability of fisheries data. Moreover, prototype marine data catalogues and quality procedures for measurement laboratories have been developed through successive EU research programmes. EMODNET is complementary to other EU initiatives in the marine domain. Parameters made available through EMODNET will facilitate the GMES marine core service which aims to deliver both short term and seasonal forecasts, hindcasts, nowcasts, and time series and climate

  14. European Education, European Citizenship? On the Role of Education in Constructing Europeanness.

    ERIC Educational Resources Information Center

    Ollikainen, Aaro

    2000-01-01

    Focuses on the role of the European Union (EU) education programs in fostering a sense of European citizenship. Addresses the five meanings given to the concept of European citizenship: (1) recognition of European heritage; (2) EU loyalty; (3) right of free movement; (4) political participation; and (5) active citizenship. (CMK)

  15. European Universe Awareness

    NASA Astrophysics Data System (ADS)

    Russo, P.; Miley, G.; Westra van Holthe, F.; Schrier, W.; Reed, S.

    2011-10-01

    The European Universe Awareness (EU-UNAWE) programme uses the beauty and grandeur of the cosmos to encourage young children, particularly those from underprivileged backgrounds, to develop an interest in science and technology and to foster a sense of global citizenship. EU-UNAWE is already active in 40 countries and comprises a global network of almost 500 astronomers, teachers and other educators. The programme was recently awarded a grant of 1.9 million euros by the European Union so that it can be further developed in five European countries and South Africa. The grant will be used to organise teacher training workshops and to develop educational materials, such as an astronomy news service for children and games. During this presentation we will outline some of the biggest achievements of EU-UNAWE to date and discuss future plans for the programme.

  16. Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature

    PubMed Central

    SIFFEL, CSABA; CORREA, ADOLFO; AMAR, EMMANUELLE; BAKKER, MARIAN K.; BERMEJO-SÁNCHEZ, EVA; BIANCA, SEBASTIANO; CASTILLA, EDUARDO E.; CLEMENTI, MAURIZIO; COCCHI, GUIDO; CSÁKY-SZUNYOGH, MELINDA; FELDKAMP, MARCIA L.; LANDAU, DANIELLE; LEONCINI, EMANUELE; LI, ZHU; LOWRY, R. BRIAN; MARENGO, LISA K.; MASTROIACOVO, PIERPAOLO; MORGAN, MARGERY; MUTCHINICK, OSVALDO M.; PIERINI, ANNA; RISSMANN, ANKE; RITVANEN, ANNUKKA; SCARANO, GIOACCHINO; SZABOVA, ELENA; OLNEY, RICHARD S.

    2015-01-01

    Bladder exstrophy (BE) is a complex congenital anomaly characterized by a defect in the closure of the lower abdominal wall and bladder. We aimed to provide an overview of the literature and conduct an epidemiologic study to describe the prevalence, and maternal and case characteristics of BE. We used data from 22 participating member programs of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). All cases were reviewed and classified as isolated, syndrome, and multiple congenital anomalies. We estimated the total prevalence of BE and calculated the frequency and odds ratios for various maternal and case characteristics. A total of 546 cases with BE were identified among 26,355,094 births. The total prevalence of BE was 2.07 per 100,000 births (95% CI: 1.90–2.25) and varied between 0.52 and 4.63 among surveillance programs participating in the study. BE was nearly twice as common among male as among female cases. The proportion of isolated cases was 71%. Prevalence appeared to increase with increasing categories of maternal age, particularly among isolated cases. The total prevalence of BE showed some variations by geographical region, which is most likely attributable to differences in registration of cases. The higher total prevalence among male cases and older mothers, especially among isolated cases, warrants further attention. PMID:22002949

  17. European Composite Honeycomb Material

    NASA Astrophysics Data System (ADS)

    Tschepe, Christoph; Sauerbrey, Martin; Klebor, Maximillian; Henriksen, Torben

    2014-06-01

    A European CFRP honeycomb material for high demanding structure applications like antenna reflectors and optical benches was developed in the frame of an ESA GSTP project.The composite honeycomb was designed according to requirements defined by the European space industry. A developed manufacturing technique based on prepreg moulding enables the production of homogeneous CFRP honeycomb blocks. All characteristic material properties, including compression, tension and shear strength and CTE, were determined in a comprehensive verification test campaign. Competitiveness to comparable products was further verified by a representative breadboard.

  18. European security and France

    SciTech Connect

    deRose, A.

    1985-01-01

    A French authority on security argues for new European initiatives in the face of the ''danger represented by Soviet military power deployed in support of an imperialistic ideology.'' His proposals, including the strengthening of conventional forces without abandoning the option of the first use of nuclear weapons, are meant to give substance to President Mitterrand's declaration in 1983: ''The European nations now need to realize that their defense is also their responsibility....'' A part of the increasingly important debate in France over defense policy in Europe.

  19. The New European Wind Atlas

    NASA Astrophysics Data System (ADS)

    Lundtang Petersen, Erik

    2013-04-01

    The New European Wind Atlas 1. European wind resource assessment through a ERA-NET Plus project 1.1 The new EU Atlas The Commission decided earlier this year to issue an ERA-NET Plus call for the creation and publication of a new EU wind atlas. The atlas will cover Member states as well as Member states' exclusive economic zones, both onshore and offshore. It involved the launch of a single joint call for proposals by promoters of national and/or regional programmes, thereby allowing a more efficient use of existing financial resources. Therefore the funding scheme is that of ERA-NET Plus which implies that at least 5 MS shall commit at least 1 million Euros each and the Commission tops up with on third of the MS contribution. Basically it is the MS research programmes that will execute the project but an important part of the project is to create "open project development platforms" with associated protocols allowing a wider range of scientists worldwide to contribute. The project has a duration of 5 years. The decision on the new wind atlas was taken after several years of work by the European Wind Energy Technology Platform and the European Energy Research Alliances' Joint programme for Wind Energy. 2. Structure of the project The project will be structured around three areas of work, to be implemented in parallel: 2.1 Creation and publication of a European wind atlas in electronic form, which will include the underlying data and a new EU wind climate database. The database will at a minimum include: Wind resources and their associated uncertainty; Extreme wind; Turbulence characteristics; Adverse weather conditions; Predictability for short term prediction; Guidelines. 2.2 Development of dynamical downscaling methodologies and open-source models. The developed downscaling methodologies and models will be fully documented and made public available and will be used to produce overview maps of wind resources and relevant data at several heights and a horizontal

  20. Concluding Comments: When International, European and Domestic Influences Collide

    ERIC Educational Resources Information Center

    Vukasovic, Martina

    2015-01-01

    The concluding commentary summarizes the contributions to the special issue, identifies a number of transversal themes and specifies their empirical and theoretical contributions. The interplay between international, European and domestic influences on national policy changes and university adaptation is highlighted. This is used as the basis for…

  1. Concluding Comments: When International, European and Domestic Influences Collide

    ERIC Educational Resources Information Center

    Vukasovic, Martina

    2015-01-01

    The concluding commentary summarizes the contributions to the special issue, identifies a number of transversal themes and specifies their empirical and theoretical contributions. The interplay between international, European and domestic influences on national policy changes and university adaptation is highlighted. This is used as the basis for…

  2. European Music Year 1985.

    ERIC Educational Resources Information Center

    Alexanderson, Thomas; And Others

    1984-01-01

    Articles concerning music are included in this newsletter dedicated to cultural venture to be jointly carried out by the Council of Europe and the European communities. Many events will mark Music Year 1985, including concerts, dance performances, operas, publications, recordings, festivals, exhibitions, competitions, and conferences on musical…

  3. The European VLBI network

    NASA Technical Reports Server (NTRS)

    Schilizzi, R. T.

    1980-01-01

    The capabilities of the European very long baseline interferometry (VLBI) network are summarized. The range of baseline parameters, sensitivities, and recording and other equipment available are included. Plans for upgrading the recording facilities and the use of geostationary satellites for signal transfer and clock synchronization are discussed.

  4. Multilingualism in European Workplaces

    ERIC Educational Resources Information Center

    Gunnarsson, Britt-Louise

    2014-01-01

    This state-of-the-art article includes a review of past and recent studies on multilingualism at work in European environments. One aim is to provide the reader with a cross-cultural picture of workplace studies on various languages in Europe, another to discuss both positive and problem-based accounts of multilingualism at work. The overview…

  5. Teaching European Identities

    ERIC Educational Resources Information Center

    Raento, Pauliina

    2008-01-01

    The political, cultural and social make-up of Europe is changing fast. A new European identity is under construction, but old contradictions and diversity challenge its contents, forms and boundaries. Migration, the changing role of the nation-state and Europe's regions, the reshaping of politico-administrative and perceptional boundaries, the…

  6. European Pine Shoot Moth

    Treesearch

    William E. Miller; Arthur R. Hastings; John F. Wootten

    1961-01-01

    In the United States, the European pine shoot moth has caused much damage in young, plantations of red pine. It has been responsible for reduced planting of red pine in many areas. Although attacked trees rarely if ever die, their growth is inhibited and many are, deformed. Scotch pine and Austrian pine (Pinus nigra Arnold) are usually not so badly damaged. Swiss...

  7. European Civilization. Teacher's Manual.

    ERIC Educational Resources Information Center

    Leppert, Ella C.; Halac, Dennis

    The instructional materials in this teaching guide for Course II, Unit IV, follow and build upon a previous sequential course described in SO 003 169 offering ninth grade students a study on the development of Western European Civilization. Focus is upon four periods of high development: The High Middle Ages (12th Century), The Renaissance (15th…

  8. Trends in European English.

    ERIC Educational Resources Information Center

    Wilkinson, Robert

    It is proposed that a European variety of English without native speakers is emerging as a language of international communication in Europe. This is a consequence of many factors, including the strength of the American economy, the breadth and depth of American research in science and technology, the pervasive influence of American-style popular…

  9. European Civilization. Teacher's Manual.

    ERIC Educational Resources Information Center

    Leppert, Ella C.; Halac, Dennis

    The instructional materials in this teaching guide for Course II, Unit IV, follow and build upon a previous sequential course described in SO 003 169 offering ninth grade students a study on the development of Western European Civilization. Focus is upon four periods of high development: The High Middle Ages (12th Century), The Renaissance (15th…

  10. Teaching European Identities

    ERIC Educational Resources Information Center

    Raento, Pauliina

    2008-01-01

    The political, cultural and social make-up of Europe is changing fast. A new European identity is under construction, but old contradictions and diversity challenge its contents, forms and boundaries. Migration, the changing role of the nation-state and Europe's regions, the reshaping of politico-administrative and perceptional boundaries, the…

  11. Multilingualism in European Workplaces

    ERIC Educational Resources Information Center

    Gunnarsson, Britt-Louise

    2014-01-01

    This state-of-the-art article includes a review of past and recent studies on multilingualism at work in European environments. One aim is to provide the reader with a cross-cultural picture of workplace studies on various languages in Europe, another to discuss both positive and problem-based accounts of multilingualism at work. The overview…

  12. European Study Tour Guidelines.

    ERIC Educational Resources Information Center

    Mitchell, Vicki L.; Mitchell, Kenneth E.

    Guidelines are presented for planning and financing European study tours at the community college level. First, a rationale for incorporating study tours of Europe within the community college curriculum is presented and the benefits of such tours in providing students with experiences they could not normally have are outlined. Next, the paper…

  13. Working towards a European Geological Data Infrastructure

    NASA Astrophysics Data System (ADS)

    van der Krogt, Rob; Hughes, Richard; Pedersen, Mikael; Serrano, Jean-Jacques; Lee, Kathryn A.; Tulstrup, Jørgen; Robida, François

    2013-04-01

    The increasing importance of geological information for policy, regulation and business needs at European and international level has been recognized by the European Parliament and the European Commission, who have called for the development of a common European geological knowledge base. The societal relevance of geoscience data/information is clear from many current issues such as shale gas exploration (including environmental impacts), the availability of critical mineral resources in a global economy, management and security with regard to geohazards (seismic, droughts, floods, ground stability), quality of (ground-)water and soil and societal responses to the impacts of climate change. The EGDI-Scope project responds to this, aiming to prepare an implementation plan for a pan-European Geological Data Infrastructure (EGDI), under the umbrella of the FP7 e- Infrastructures program. It is envisaged that the EGDI will build on geological datasets and models currently held by the European Geological Surveys at national and regional levels, and will also provide a platform for datasets generated by the large number of relevant past, ongoing and future European projects which have geological components. With European policy makers and decision makers from (international) industry as the main target groups (followed by research communities and the general public) stakeholder involvement is imperative to the successful realization and continuity of the EGDI. With these ambitions in mind, the presentation will focus on the following issues, also based on the first results and experiences of the EGDI-Scope project that started mid-2012: • The organization of stakeholder input and commitment connected to relevant 'use cases' within different thematic domains; a number of stakeholder representatives is currently involved, but the project is open to more extensive participation; • A large number of European projects relevant for data delivery to EGDI has been reviewed

  14. Ancient human genomes suggest three ancestral populations for present-day Europeans.

    PubMed

    Lazaridis, Iosif; Patterson, Nick; Mittnik, Alissa; Renaud, Gabriel; Mallick, Swapan; Kirsanow, Karola; Sudmant, Peter H; Schraiber, Joshua G; Castellano, Sergi; Lipson, Mark; Berger, Bonnie; Economou, Christos; Bollongino, Ruth; Fu, Qiaomei; Bos, Kirsten I; Nordenfelt, Susanne; Li, Heng; de Filippo, Cesare; Prüfer, Kay; Sawyer, Susanna; Posth, Cosimo; Haak, Wolfgang; Hallgren, Fredrik; Fornander, Elin; Rohland, Nadin; Delsate, Dominique; Francken, Michael; Guinet, Jean-Michel; Wahl, Joachim; Ayodo, George; Babiker, Hamza A; Bailliet, Graciela; Balanovska, Elena; Balanovsky, Oleg; Barrantes, Ramiro; Bedoya, Gabriel; Ben-Ami, Haim; Bene, Judit; Berrada, Fouad; Bravi, Claudio M; Brisighelli, Francesca; Busby, George B J; Cali, Francesco; Churnosov, Mikhail; Cole, David E C; Corach, Daniel; Damba, Larissa; van Driem, George; Dryomov, Stanislav; Dugoujon, Jean-Michel; Fedorova, Sardana A; Gallego Romero, Irene; Gubina, Marina; Hammer, Michael; Henn, Brenna M; Hervig, Tor; Hodoglugil, Ugur; Jha, Aashish R; Karachanak-Yankova, Sena; Khusainova, Rita; Khusnutdinova, Elza; Kittles, Rick; Kivisild, Toomas; Klitz, William; Kučinskas, Vaidutis; Kushniarevich, Alena; Laredj, Leila; Litvinov, Sergey; Loukidis, Theologos; Mahley, Robert W; Melegh, Béla; Metspalu, Ene; Molina, Julio; Mountain, Joanna; Näkkäläjärvi, Klemetti; Nesheva, Desislava; Nyambo, Thomas; Osipova, Ludmila; Parik, Jüri; Platonov, Fedor; Posukh, Olga; Romano, Valentino; Rothhammer, Francisco; Rudan, Igor; Ruizbakiev, Ruslan; Sahakyan, Hovhannes; Sajantila, Antti; Salas, Antonio; Starikovskaya, Elena B; Tarekegn, Ayele; Toncheva, Draga; Turdikulova, Shahlo; Uktveryte, Ingrida; Utevska, Olga; Vasquez, René; Villena, Mercedes; Voevoda, Mikhail; Winkler, Cheryl A; Yepiskoposyan, Levon; Zalloua, Pierre; Zemunik, Tatijana; Cooper, Alan; Capelli, Cristian; Thomas, Mark G; Ruiz-Linares, Andres; Tishkoff, Sarah A; Singh, Lalji; Thangaraj, Kumarasamy; Villems, Richard; Comas, David; Sukernik, Rem; Metspalu, Mait; Meyer, Matthias; Eichler, Evan E; Burger, Joachim; Slatkin, Montgomery; Pääbo, Svante; Kelso, Janet; Reich, David; Krause, Johannes

    2014-09-18

    We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ∼44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.

  15. Intergenerational Practice: Contributing to a Conceptual Framework

    ERIC Educational Resources Information Center

    Vieira, Sacha; Sousa, Liliana

    2016-01-01

    The ageing of the European population is creating a new demographic mix, increasing the relevance of intergenerational practice (IGP). To date, however, this field lacks an appropriate conceptual framework. This study aims to contribute to such a framework through an integrative review of peer-reviewed papers reporting on IGPs. Fifteen papers were…

  16. Intergenerational Practice: Contributing to a Conceptual Framework

    ERIC Educational Resources Information Center

    Vieira, Sacha; Sousa, Liliana

    2016-01-01

    The ageing of the European population is creating a new demographic mix, increasing the relevance of intergenerational practice (IGP). To date, however, this field lacks an appropriate conceptual framework. This study aims to contribute to such a framework through an integrative review of peer-reviewed papers reporting on IGPs. Fifteen papers were…

  17. Chemists Creating a European Identity through Conferences and Journals.

    PubMed

    Oro, Luis A

    2016-09-05

    " … The 6th EuCheMS Chemistry Congress will take place in Seville in September 2016. EuCheMS represents more than 160 000 chemists from more than 40 member societies. ChemPubSoc Europe is an organization of 16 European chemical societies from 15 countries. These initiatives have contributed significantly to the creation of a European identity for chemistry …" Read more in the Editorial by Luis A. Oro.

  18. The European Mobile System (EMS)

    NASA Technical Reports Server (NTRS)

    Jongejans, A.; Rogard, R.; Mistretta, I.; Ananasso, F.

    1993-01-01

    The European Space Agency is presently procuring an L band payload in order to promote a regional European L band system coping with the specific needs of the European market. The payload, and the two communications systems to be supported, are described below. The potential market for EMS in Europe is discussed.

  19. Brazil to Join the European Southern Observatory

    NASA Astrophysics Data System (ADS)

    2010-12-01

    The Federative Republic of Brazil has yesterday signed the formal accession agreement paving the way for it to become a Member State of the European Southern Observatory (ESO). Following government ratification Brazil will become the fifteenth Member State and the first from outside Europe. On 29 December 2010, at a ceremony in Brasilia, the Brazilian Minister of Science and Technology, Sergio Machado Rezende and the ESO Director General, Tim de Zeeuw signed the formal accession agreement aiming to make Brazil a Member State of the European Southern Observatory. Brazil will become the fifteen Member State and the first from outside Europe. Since the agreement means accession to an international convention, the agreement must now be submitted to the Brazilian Parliament for ratification [1]. The signing of the agreement followed the unanimous approval by the ESO Council during an extraordinary meeting on 21 December 2010. "Joining ESO will give new impetus to the development of science, technology and innovation in Brazil as part of the considerable efforts our government is making to keep the country advancing in these strategic areas," says Rezende. The European Southern Observatory has a long history of successful involvement with South America, ever since Chile was selected as the best site for its observatories in 1963. Until now, however, no non-European country has joined ESO as a Member State. "The membership of Brazil will give the vibrant Brazilian astronomical community full access to the most productive observatory in the world and open up opportunities for Brazilian high-tech industry to contribute to the European Extremely Large Telescope project. It will also bring new resources and skills to the organisation at the right time for them to make a major contribution to this exciting project," adds ESO Director General, Tim de Zeeuw. The European Extremely Large Telescope (E-ELT) telescope design phase was recently completed and a major review was

  20. Education and European integration

    NASA Astrophysics Data System (ADS)

    Lowe, John

    1992-11-01

    The main purpose of this article is to discuss the implications for education and training of the movement towards integration in Europe in the historic context of the creation of a single market within the European Community (EC) and the end of the Communist regimes in Central and Eastern Europe. The experience of the EC is used to illustrate trends and problems in the development of international cooperation in education and training. Common concerns and priorities throughout the new Europe are then identified and discussed. These include the pursuit of quality in schooling, efforts to serve the interests of disadvantaged learners, and the treatment of European Studies in the curriculum, including the improvement of the teaching of foreign languages.

  1. Chestnut, European (Castanea sativa).

    PubMed

    Corredoira, Elena; Valladares, Silvia; Vieitez, Ana M; Ballester, Antonio

    2015-01-01

    Development of a system for direct transfer of antifungal candidate genes into European chestnut (Castanea sativa) would provide an alternative approach to conventional breeding for production of chestnut trees that are tolerant to ink disease caused by Phytophthora spp. Overexpression of genes encoding PR proteins (such as thaumatin-like proteins), which display antifungal activity, may represent an important advance in control of the disease. We have used a chestnut thaumatin-like protein gene (CsTL1) isolated from European chestnut cotyledons and have achieved overexpression of the gene in chestnut somatic embryogenic lines used as target material. We have also acclimatized the transgenic plants and grown them on in the greenhouse. Here, we describe the various steps of the process, from the induction of somatic embryogenesis to the production of transgenic plants.

  2. Investigating European genetic history through computer simulations.

    PubMed

    Currat, Mathias; Silva, Nuno M

    2013-01-01

    The genetic diversity of Europeans has been shaped by various evolutionary forces including their demographic history. Genetic data can thus be used to draw inferences on the population history of Europe using appropriate statistical methods such as computer simulation, which constitutes a powerful tool to study complex models. Here, we focus on spatially explicit simulation, a method which takes population movements over space and time into account. We present its main principles and then describe a series of studies using this approach that we consider as particularly significant in the context of European prehistory. All simulation studies agree that ancient demographic events played a significant role in the establishment of the European gene pool; but while earlier works support a major genetic input from the Near East during the Neolithic transition, the most recent ones revalue positively the contribution of pre-Neolithic hunter-gatherers and suggest a possible impact of very ancient demographic events. This result of a substantial genetic continuity from pre-Neolithic times to the present challenges some recent studies analyzing ancient DNA. We discuss the possible reasons for this discrepancy and identify future lines of investigation in order to get a better understanding of European evolution.

  3. PRACE - The European HPC Infrastructure

    NASA Astrophysics Data System (ADS)

    Stadelmeyer, Peter

    2014-05-01

    The mission of PRACE (Partnership for Advanced Computing in Europe) is to enable high impact scientific discovery and engineering research and development across all disciplines to enhance European competitiveness for the benefit of society. PRACE seeks to realize this mission by offering world class computing and data management resources and services through a peer review process. This talk gives a general overview about PRACE and the PRACE research infrastructure (RI). PRACE is established as an international not-for-profit association and the PRACE RI is a pan-European supercomputing infrastructure which offers access to computing and data management resources at partner sites distributed throughout Europe. Besides a short summary about the organization, history, and activities of PRACE, it is explained how scientists and researchers from academia and industry from around the world can access PRACE systems and which education and training activities are offered by PRACE. The overview also contains a selection of PRACE contributions to societal challenges and ongoing activities. Examples of the latter are beside others petascaling, application benchmark suite, best practice guides for efficient use of key architectures, application enabling / scaling, new programming models, and industrial applications. The Partnership for Advanced Computing in Europe (PRACE) is an international non-profit association with its seat in Brussels. The PRACE Research Infrastructure provides a persistent world-class high performance computing service for scientists and researchers from academia and industry in Europe. The computer systems and their operations accessible through PRACE are provided by 4 PRACE members (BSC representing Spain, CINECA representing Italy, GCS representing Germany and GENCI representing France). The Implementation Phase of PRACE receives funding from the EU's Seventh Framework Programme (FP7/2007-2013) under grant agreements RI-261557, RI-283493 and RI

  4. Telemedicine and European law.

    PubMed

    Callens, Stefaan

    2003-01-01

    A Directive of the European Union was first published in 2000, which dealt with telemedicine as part of its provisions. This E-Commerce Directive, as it became known, was subjected to further study which revealed some problems relative to the practice of telemedicine. Among the subjects discussed in this paper are those of privacy, data protection, free movement of services, the impact of electronic communication and ethical issues.

  5. The European Spallation Source

    SciTech Connect

    Peggs, S; Eshraqi, M; Hahn, H; Jansson, A; Lindroos, M; Ponton, A; Rathsman, K; Trahern, G; Bousso, S; Calaga, R; Devanz, G; Duperrier, R D; Eguia, J; Gammino, S; Moller, S P; Oyon, C; Ruber, R.J.M.Y.; Satogata, T

    2011-03-01

    The European Spallation Source (ESS) is a 5 MW, 2.5 GeV long pulse proton linac, to be built and commissioned in Lund, Sweden. The Accelerator Design Update (ADU) project phase is under way, to be completed at the end of 2012 by the delivery of a Technical Design Report. Improvements to the 2003 ESS design will be summarised, and the latest design activities will be presented.

  6. Trans-Nationalization of Educational Policy Making: From European Innovation Projects in Adult Education to an Emerging European Space for Lifelong Learning: What Model for the European Vocational Education and Training Policy?

    ERIC Educational Resources Information Center

    Bonnafous, Laurence

    2014-01-01

    This article is drawn from broader qualitative research on innovation in the field of professional adult training within the framework of European pilot projects such as the LEONARDO projects. This research aims at contributing to a general understanding of the phenomenon of innovation, in the context of European calls for projects, as an…

  7. Trans-Nationalization of Educational Policy Making: From European Innovation Projects in Adult Education to an Emerging European Space for Lifelong Learning: What Model for the European Vocational Education and Training Policy?

    ERIC Educational Resources Information Center

    Bonnafous, Laurence

    2014-01-01

    This article is drawn from broader qualitative research on innovation in the field of professional adult training within the framework of European pilot projects such as the LEONARDO projects. This research aims at contributing to a general understanding of the phenomenon of innovation, in the context of European calls for projects, as an…

  8. The Organization of European Cancer Institute Pathobiology Working Group and its support of European biobanking infrastructures for translational cancer research.

    PubMed

    Riegman, Peter H J; de Jong, Bas W D; Llombart-Bosch, Antonio

    2010-04-01

    Today's translational cancer research increasingly depends on international multi-center studies. Biobanking infrastructure or comprehensive sample exchange platforms to enable networking of clinical cancer biobanks are instrumental to facilitate communication, uniform sample quality, and rules for exchange. The Organization of European Cancer Institutes (OECI) Pathobiology Working Group supports European biobanking infrastructure by maintaining the OECI-TuBaFrost exchange platform and organizing regular meetings. This platform originated from a European Commission project and is updated with knowledge from ongoing and new biobanking projects. This overview describes how European biobanking projects that have a large impact on clinical biobanking, including EuroBoNeT, SPIDIA, and BBMRI, contribute to the update of the OECI-TuBaFrost exchange platform. Combining the results of these European projects enabled the creation of an open (upon valid registration only) catalogue view of cancer biobanks and their available samples to initiate research projects. In addition, closed environments supporting active projects could be developed together with the latest views on quality, access rules, ethics, and law. With these contributions, the OECI Pathobiology Working Group contributes to and stimulates a professional attitude within biobanks at the European comprehensive cancer centers. Improving the fundamentals of cancer sample exchange in Europe stimulates the performance of large multi-center studies, resulting in experiments with the desired statistical significance outcome. With this approach, future innovation in cancer patient care can be realized faster and more reliably.

  9. Sirenomelia: an epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research, and literature review.

    PubMed

    Orioli, Iêda M; Amar, Emmanuelle; Arteaga-Vazquez, Jazmin; Bakker, Marian K; Bianca, Sebastiano; Botto, Lorenzo D; Clementi, Maurizio; Correa, Adolfo; Csaky-Szunyogh, Melinda; Leoncini, Emanuele; Li, Zhu; López-Camelo, Jorge S; Lowry, R Brian; Marengo, Lisa; Martínez-Frías, María-Luisa; Mastroiacovo, Pierpaolo; Morgan, Margery; Pierini, Anna; Ritvanen, Annukka; Scarano, Gioacchino; Szabova, Elena; Castilla, Eduardo E

    2011-11-15

    Sirenomelia is a very rare limb anomaly in which the normally paired lower limbs are replaced by a single midline limb. This study describes the prevalence, associated malformations, and maternal characteristics among cases with sirenomelia. Data originated from 19 birth defect surveillance system members of the International Clearinghouse for Birth Defects Surveillance and Research, and were reported according to a single pre-established protocol. Cases were clinically evaluated locally and reviewed centrally. A total of 249 cases with sirenomelia were identified among 25,290,172 births, for a prevalence of 0.98 per 100,000, with higher prevalence in the Mexican registry. An increase of sirenomelia prevalence with maternal age less than 20 years was statistically significant. The proportion of twinning was 9%, higher than the 1% expected. Sex was ambiguous in 47% of cases, and no different from expectation in the rest. The proportion of cases born alive, premature, and weighting less than 2,500 g were 47%, 71.2%, and 88.2%, respectively. Half of the cases with sirenomelia also presented with genital, large bowel, and urinary defects. About 10-15% of the cases had lower spinal column defects, single or anomalous umbilical artery, upper limb, cardiac, and central nervous system defects. There was a greater than expected association of sirenomelia with other very rare defects such as bladder exstrophy, cyclopia/holoprosencephaly, and acardia-acephalus. The application of the new biological network analysis approach, including molecular results, to these associated very rare diseases is suggested for future studies.

  10. Sirenomelia: An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research, and Literature Review

    PubMed Central

    ORIOLI, IÊDA M.; AMAR, EMMANUELLE; ARTEAGA-VAZQUEZ, JAZMIN; BAKKER, MARIAN K.; BIANCA, SEBASTIANO; BOTTO, LORENZO D.; CLEMENTI, MAURIZIO; CORREA, ADOLFO; CSAKY-SZUNYOGH, MELINDA; LEONCINI, EMANUELE; LI, ZHU; LÓPEZ-CAMELO, JORGE S.; LOWRY, R. BRIAN; MARENGO, LISA; MARTÍNEZ-FRÍAS, MARÍA-LUISA; MASTROIACOVO, PIERPAOLO; MORGAN, MARGERY; PIERINI, ANNA; RITVANEN, ANNUKKA; SCARANO, GIOACCHINO; SZABOVA, ELENA; CASTILLA, EDUARDO E.

    2015-01-01

    Sirenomelia is a very rare limb anomaly in which the normally paired lower limbs are replaced by a single midline limb. This study describes the prevalence, associated malformations, and maternal characteristics among cases with sirenomelia. Data originated from 19 birth defect surveillance system members of the International Clearinghouse for Birth Defects Surveillance and Research, and were reported according to a single pre-established protocol. Cases were clinically evaluated locally and reviewed centrally. A total of 249 cases with sirenomelia were identified among 25,290,172 births, for a prevalence of 0.98 per 100,000, with higher prevalence in the Mexican registry. An increase of sirenomelia prevalence with maternal age less than 20 years was statistically significant. The proportion of twinning was 9%, higher than the 1% expected. Sex was ambiguous in 47% of cases, and no different from expectation in the rest. The proportion of cases born alive, premature, and weighting less than 2,500 g were 47%, 71.2%, and 88.2%, respectively. Half of the cases with sirenomelia also presented with genital, large bowel, and urinary defects. About 10–15% of the cases had lower spinal column defects, single or anomalous umbilical artery, upper limb, cardiac, and central nervous system defects. There was a greater than expected association of sirenomelia with other very rare defects such as bladder exstrophy, cyclopia/holoprosencephaly, and acardia-acephalus. The application of the new biological network analysis approach, including molecular results, to these associated very rare diseases is suggested for future studies. PMID:22002878

  11. Amelia: A Multi-Center Descriptive Epidemiologic Study in a Large Dataset from the International Clearinghouse for Birth Defects Surveillance and Research, and Overview of the Literature

    PubMed Central

    BERMEJO-SÁNCHEZ, EVA; CUEVAS, LOURDES; AMAR, EMMANUELLE; BAKKER, MARIAN K.; BIANCA, SEBASTIANO; BIANCHI, FABRIZIO; CANFIELD, MARK A.; CASTILLA, EDUARDO E.; CLEMENTI, MAURIZIO; COCCHI, GUIDO; FELDKAMP, MARCIA L.; LANDAU, DANIELLE; LEONCINI, EMANUELE; LI, ZHU; LOWRY, R. BRIAN; MASTROIACOVO, PIERPAOLO; MUTCHINICK, OSVALDO M.; RISSMANN, ANKE; RITVANEN, ANNUKKA; SCARANO, GIOACCHINO; SIFFEL, CSABA; SZABOVA, ELENA; MARTÍNEZ-FRÍAS, MARÍA-LUISA

    2015-01-01

    This study describes the epidemiology of congenital amelia (absence of limb/s), using the largest series of cases known to date. Data were gathered by 20 surveillance programs on congenital anomalies, all International Clearinghouse for Birth Defects Surveillance and Research members, from all continents but Africa, from 1968 to 2006, depending on the program. Reported clinical information on cases was thoroughly reviewed to identify those strictly meeting the definition of amelia. Those with amniotic bands or limb-body wall complex were excluded. The primary epidemiological analyses focused on isolated cases and those with multiple congenital anomalies (MCA). A total of 326 amelia cases were ascertained among 23,110,591 live births, stillbirths and (for some programs) elective terminations of pregnancy for fetal anomalies. The overall total prevalence was 1.41 per 100,000 (95% confidence interval: 1.26–1.57). Only China Beijing and Mexico RYVEMCE had total prevalences, which were significantly higher than this overall total prevalence. Some under-registration could influence the total prevalence in some programs. Liveborn cases represented 54.6% of total. Among monomelic cases (representing 65.2% of nonsyndromic amelia cases), both sides were equally involved, and the upper limbs (53.9%) were slightly more frequently affected. One of the most interesting findings was a higher prevalence of amelia among offspring of mothers younger than 20 years. Sixty-nine percent of the cases had MCA or syndromes. The most frequent defects associated with amelia were other types of musculoskeletal defects, intestinal, some renal and genital defects, oral clefts, defects of cardiac septa, and anencephaly. PMID:22002956

  12. Phocomelia: A Worldwide Descriptive Epidemiologic Study in a Large Series of Cases From the International Clearinghouse for Birth Defects Surveillance and Research, and Overview of the Literature

    PubMed Central

    Bermejo-Sánchez, Eva; Cuevas, Lourdes; Amar, Emmanuelle; Bianca, Sebastiano; Bianchi, Fabrizio; Botto, Lorenzo D.; Canfield, Mark A.; Castilla, Eduardo E.; Clementi, Maurizio; Cocchi, Guido; Landau, Danielle; Leoncini, Emanuele; Li, Zhu; Lowry, R. Brian; Mastroiacovo, Pierpaolo; Mutchinick, Osvaldo M.; Rissmann, Anke; Ritvanen, Annukka; Scarano, Gioacchino; Siffel, Csaba; Szabova, Elena; Martínez-Frías, María-Luisa

    2015-01-01

    Epidemiologic data on phocomelia are scarce. This study presents an epidemiologic analysis of the largest series of phocomelia cases known to date. Data were provided by 19 birth defect surveillance programs, all members of the International Clearinghouse for Birth Defects Surveillance and Research. Depending on the program, data corresponded to a period from 1968 through 2006. A total of 22,740,933 live births, stillbirths and, for some programs, elective terminations of pregnancy for fetal anomaly (ETOPFA) were monitored. After a detailed review of clinical data, only true phocomelia cases were included. Descriptive data are presented and additional analyses compared isolated cases with those with multiple congenital anomalies (MCA), excluding syndromes. We also briefly compared congenital anomalies associated with nonsyndromic phocomelia with those presented with amelia, another rare severe congenital limb defect. A total of 141 phocomelia cases registered gave an overall total prevalence of 0.62 per 100,000 births (95% confidence interval: 0.52–0.73). Three programs (Australia Victoria, South America ECLAMC, Italy North East) had significantly different prevalence estimates. Most cases (53.2%) had isolated phocomelia, while 9.9% had syndromes. Most nonsyndromic cases were monomelic (55.9%), with an excess of left (64.9%) and upper limb (64.9%) involvement. Most nonsyndromic cases (66.9%) were live births; most isolated cases (57.9%) weighed more than 2,499 g; most MCA (60.7%) weighed less than 2,500 g, and were more likely stillbirths (30.8%) or ETOPFA (15.4%) than isolated cases. The most common associated defects were musculoskeletal, cardiac, and intestinal. Epidemiological differences between phocomelia and amelia highlighted possible differences in their causes. PMID:22002800

  13. A Report of Progress. Annual Report of the NFE Network Project: Operating a Clearinghouse on NFE Information (September 1981-August 1982) and Semi-Annual Reports of the NFE Network Project: Providing Technical Assistance in Creating LDC National/Regional Information Centers (September 1981-February 1982; March 1982-August 1982).

    ERIC Educational Resources Information Center

    Pigozzi, Mary Joy

    This report describes the clearinghouse activities of the Non-Formal Education (NFE) Information Center from September 1981 through August 1982 and details efforts to strengthen the capacity of selected NFE resource centers in Africa, Asia, and Latin America. It first addresses the decision to extend the NFE Network Project, and then turns to the…

  14. Nobel prizes: contributions to cardiology.

    PubMed

    Mesquita, Evandro Tinoco; Marchese, Luana de Decco; Dias, Danielle Warol; Barbeito, Andressa Brasil; Gomes, Jonathan Costa; Muradas, Maria Clara Soares; Lanzieri, Pedro Gemal; Gismondi, Ronaldo Altenburg

    2015-08-01

    The Nobel Prize was created by Alfred Nobel. The first prize was awarded in 1901 and Emil Adolf von Behring was the first laureate in medicine due to his research in diphtheria serum. Regarding cardiology, Nobel Prize's history permits a global comprehension of progress in pathophysiology, diagnosis and therapeutics of various cardiac diseases in last 120 years. The objective of this study was to review the major scientific discoveries contemplated by Nobel Prizes that contributed to cardiology. In addition, we also hypothesized why Carlos Chagas, one of our most important scientists, did not win the prize in two occasions. We carried out a non-systematic review of Nobel Prize winners, selecting the main studies relevant to heart diseaseamong the laureates. In the period between 1901 and 2013, 204 researches and 104 prizes were awarded in Nobel Prize, of which 16 (15%) studies were important for cardiovascular area. There were 33 (16%) laureates, and two (6%) were women. Fourteen (42%) were American, 15 (45%) Europeans and four (13%) were from other countries. There was only one winner born in Brazil, Peter Medawar, whose career was all in England. Reviewing the history of the Nobel Prize in physiology or medicine area made possible to identify which researchers and studies had contributed to advances in the diagnosis, prevention and treatment of cardiovascular diseases. Most winners were North Americans and Europeans, and male.

  15. Nobel Prizes: Contributions to Cardiology

    PubMed Central

    Mesquita, Evandro Tinoco; Marchese, Luana de Decco; Dias, Danielle Warol; Barbeito, Andressa Brasil; Gomes, Jonathan Costa; Muradas, Maria Clara Soares; Lanzieri, Pedro Gemal; Gismondi, Ronaldo Altenburg

    2015-01-01

    The Nobel Prize was created by Alfred Nobel. The first prize was awarded in 1901 and Emil Adolf von Behring was the first laureate in medicine due to his research in diphtheria serum. Regarding cardiology, Nobel Prize’s history permits a global comprehension of progress in pathophysiology, diagnosis and therapeutics of various cardiac diseases in last 120 years. The objective of this study was to review the major scientific discoveries contemplated by Nobel Prizes that contributed to cardiology. In addition, we also hypothesized why Carlos Chagas, one of our most important scientists, did not win the prize in two occasions. We carried out a non-systematic review of Nobel Prize winners, selecting the main studies relevant to heart diseaseamong the laureates. In the period between 1901 and 2013, 204 researches and 104 prizes were awarded in Nobel Prize, of which 16 (15%) studies were important for cardiovascular area. There were 33 (16%) laureates, and two (6%) were women. Fourteen (42%) were American, 15 (45%) Europeans and four (13%) were from other countries. There was only one winner born in Brazil, Peter Medawar, whose career was all in England. Reviewing the history of the Nobel Prize in physiology or medicine area made possible to identify which researchers and studies had contributed to advances in the diagnosis, prevention and treatment of cardiovascular diseases. Most winners were North Americans and Europeans, and male. PMID:25945466

  16. Supernovae and cosmology with future European facilities.

    PubMed

    Hook, I M

    2013-06-13

    Prospects for future supernova surveys are discussed, focusing on the European Space Agency's Euclid mission and the European Extremely Large Telescope (E-ELT), both expected to be in operation around the turn of the decade. Euclid is a 1.2 m space survey telescope that will operate at visible and near-infrared wavelengths, and has the potential to find and obtain multi-band lightcurves for thousands of distant supernovae. The E-ELT is a planned, general-purpose ground-based, 40-m-class optical-infrared telescope with adaptive optics built in, which will be capable of obtaining spectra of type Ia supernovae to redshifts of at least four. The contribution to supernova cosmology with these facilities will be discussed in the context of other future supernova programmes such as those proposed for DES, JWST, LSST and WFIRST.

  17. The ESA Initiatives towards European Technical Universities

    NASA Astrophysics Data System (ADS)

    Messina, P.

    2002-01-01

    Education is one of the ESA mandatory activities and a renewed commitment has been shown by the reinforcement of the ESA Education Office and by the launching new initiatives in addition to those already in place. The new structure of the Office includes, next to units dealing with primary and secondary schools and with other Educational projects, a service dedicated to, among other things, foster the relations with European Universities and their students. In line with the overall objectives and strategy of Education policy at ESA, the fostering of co- operation between ESA and European Universities is aimed at creating a coherent and effective framework for the two parties to mutually benefit from an enhanced collaboration. ESA has a long and successful tradition of working together Academia, especially in the field of research and development. This new initiative wants to leverage on the past and present collaboration and reinforce the links from an educational point of view. The paper will give on overview how these links are being created, the impact on the ESA offer in terms of traineeship and opportunities for young people and will draw the first conclusions from the initial experiences gathered. Also it will address the impact of the on-going europeanisation process of higher education on the relations with European Universities and on the ESA programmes offered to them. Examples of on-going co-operation will be given (e.g. Aurora Programme) with an analysis of the lesson learned. The wider European context and how ESA's efforts contribute to the creation of a European Research Area (ERA) and to the achievement of the objectives set forth by the Lisbon summit will also be touched upon. The conclusions will address the next steps in this initiative and the feedback from the various partners and how this is being taken into account to steer the it to respond to the real needs of higher education.

  18. European Commission activities in eHealth.

    PubMed

    Olsson, Silas; Lymberis, Andreas; Whitehouse, Diane

    2004-12-01

    Health-care is an information-intensive and knowledge-demanding sector, which is why eHealth solutions are so important in this field. The European Commission (EC) has been initiating and funding research and development activities regarding Information and Communication Technologies (ICT) for health, or "eHealth", since 1988. These programmes covered priority topics like electronic health-care records, regional and national health networks, telemedicine in homecare and care-at-the-point-of-need to support continuity of care concepts, systems to support people to stay healthy, and systems and tools to support health professionals to work more efficiently and safely on patients. During the 15-year span of the programmes, the European Union (EU) has contributed about 500 million Euro to approximately 400 R&D projects, support activities, best practice and studies covering technical, clinical, ethical, legal, organisational and market issues. eHealth has shown proven benefits in application fields like improved access to care, care at the point-of-need, citizen-centred care, improved quality and cost containment. Such applications were on show at the EU High Level eHealth Conferences in Brussels, Belgium, in 2003, and in Cork, Ireland, in 2004. eHealth is now on the governmental agenda of EU Member States to be implemented on a broader scale. In line with this development, the Commission has taken a number of policy initiatives. A European Union Action Plan for a European eHealth Area was published by the Commission in April 2004 and endorsed by the EU health ministers in June 2004. This means that, for the first time, Europe has a coherent agenda for the implementation of eHealth. This report will concentrate on eHealth activities initiated by the Information Society Directorate-General of the European Commission.

  19. Eastern European risk management

    SciTech Connect

    Honey, J.A. )

    1992-01-01

    Here the authors assess Eastern European risk management practices through the evaluation of the nuclear power plants in the region. This evaluation is limited to the Soviet-designed and -built VVER-440 pressurized water reactors (PWRs) that are currently operating in Bulgaria, Czechoslovakia, Hungary, Russia, and the Ukraine and until recently operated at Greifswald in the former East Germany. This evaluation is based on the basic design of the plants, a safety evaluation of the Greifswald facility by representatives from the Federal Republic of Germany and personal visits by the author to Greifswald and Loviisa.

  20. Biophotonics: a European perspective

    NASA Astrophysics Data System (ADS)

    Robin, Thierry; Cochard, Jacques; Breussin, Frédéric

    2013-03-01

    The objective of the present work is to determine the opportunities and challenges for Biophotonics business development in Europe for the next five years with a focus on sensors and systems: for health diagnostics and monitoring; for air, water and food safety and quality control. The development of this roadmap was initiated and supported by EPIC (The European Photonics Industry Consortium). We summarize the final roadmap data: market application segments and trends, analysis of the market access criteria, analysis of the technology trends and major bottlenecks and challenges per application.

  1. Small area detectors at the European XFEL

    NASA Astrophysics Data System (ADS)

    Turcato, M.; Gessler, P.; Hauf, S.; Kuster, M.; Meyer, M.; Nordgren, J.; Sztuk-Dambietz, J.; Youngman, C.

    2014-05-01

    The detectors to be used at the European XFEL have to deal with the unique time structure of the machine, delivering up to 2700 pulses, with a repetition rate of 4.5 MHz, ten times per second, the very high photon flux and the need to combine single-photon sensitivity and a large dynamic range. This represents a challenge not only for the large-area 2D imaging detectors but also for the smaller-area detectors and makes the use of standard commercial devices impossible. Dedicated solutions are therefore envisaged for small imaging- or strip-detectors. In this contribution the focus is put on two particular small-area detector solutions which are planned to be used at the European XFEL, a strip detector for hard X-rays (with energy 3 < E < 25 keV) and an imaging detector for soft X-rays (0.25 < E < 3 keV). Hard X-rays photon-beam diagnostics as well as hard X-ray absorption and emission spectroscopy at the European XFEL make use of strip detectors as detectors for beam spectrometers or as energy-dispersive detectors in combination with an energy-dispersive element. The European XFEL is establishing cooperation with the Paul Scherrer Institute in Villigen to develop a new version of the Gotthard detector best suited to the European XFEL needs. The use case and the required detector specifications are illustrated. Starting from the present detector version, the modifications planned to adapt it to the European XFEL running conditions are described. These include the capability of running at an increased rate and to provide a veto signal to the large 2D imaging detectors, in order to be able to remove non-interesting images already at early stages of the DAQ system. In another particular application, resonant inelastic X-ray scattering, a Micro-Channel Plate detector matched to a delay-line readout is foreseen to be used. In this case the European XFEL is aiming for a highly customized solution provided by the German company Surface Concept. The use case is described

  2. The European Infrasound Bulletin

    NASA Astrophysics Data System (ADS)

    Pilger, Christoph; Ceranna, Lars; Ross, J. Ole; Vergoz, Julien; Le Pichon, Alexis; Mialle, Pierrick

    2017-04-01

    The European Infrasound Bulletin highlights infrasound activity produced by mostly anthropogenic sources, recorded all over Europe and collected in the course of the ARISE project (Atmospheric dynamics Research InfraStructure in Europe). Data includes high frequency (>0.7 Hz) infrasound detections of 24 European infrasound arrays from 9 different national institutions (BGR, CEA, IRF, NORSAR, KNMI, UNIFI, IAP-Prague, NIEP, SOREQ) complemented with CTBT IMS infrasound stations. Data was acquired during 16 years of operation (from 2000 to 2015), and processed to identify and localize about 48.000 infrasound events within Europe (20°W-40°E, 30°N-72°N). The source location of these events was derived by combining at least two corresponding station detections per event. Comparisons to ground-truth sources, as e.g. Scandinavian mining activity, are provided. Relocation is performed using ray-tracing methods to estimate celerity and back-azimuth corrections based on either HWM-07/MSISE-00 climatologies or actual ECMWF wind and temperature values for each event. This study focuses on repeating infrasound events (e.g. mining blasts and supersonic flights) and on the seasonal, weekly and diurnal variation of the infrasonic activity of sources in Europe. Estimations of the detection and location capability and accuracy will be given in the course of this study to achieve a comprehensive picture of the activity of infrasound sources and capability of infrasound station in Europe.

  3. A Predominantly Neolithic Origin for European Paternal Lineages

    PubMed Central

    Balaresque, Patricia; Bowden, Georgina R.; Adams, Susan M.; Leung, Ho-Yee; King, Turi E.; Rosser, Zoë H.; Goodwin, Jane; Moisan, Jean-Paul; Richard, Christelle; Millward, Ann; Demaine, Andrew G.; Barbujani, Guido; Previderè, Carlo; Wilson, Ian J.; Tyler-Smith, Chris; Jobling, Mark A.

    2010-01-01

    The relative contributions to modern European populations of Paleolithic hunter-gatherers and Neolithic farmers from the Near East have been intensely debated. Haplogroup R1b1b2 (R-M269) is the commonest European Y-chromosomal lineage, increasing in frequency from east to west, and carried by 110 million European men. Previous studies suggested a Paleolithic origin, but here we show that the geographical distribution of its microsatellite diversity is best explained by spread from a single source in the Near East via Anatolia during the Neolithic. Taken with evidence on the origins of other haplogroups, this indicates that most European Y chromosomes originate in the Neolithic expansion. This reinterpretation makes Europe a prime example of how technological and cultural change is linked with the expansion of a Y-chromosomal lineage, and the contrast of this pattern with that shown by maternally inherited mitochondrial DNA suggests a unique role for males in the transition. PMID:20087410

  4. A predominantly neolithic origin for European paternal lineages.

    PubMed

    Balaresque, Patricia; Bowden, Georgina R; Adams, Susan M; Leung, Ho-Yee; King, Turi E; Rosser, Zoë H; Goodwin, Jane; Moisan, Jean-Paul; Richard, Christelle; Millward, Ann; Demaine, Andrew G; Barbujani, Guido; Previderè, Carlo; Wilson, Ian J; Tyler-Smith, Chris; Jobling, Mark A

    2010-01-19

    The relative contributions to modern European populations of Paleolithic hunter-gatherers and Neolithic farmers from the Near East have been intensely debated. Haplogroup R1b1b2 (R-M269) is the commonest European Y-chromosomal lineage, increasing in frequency from east to west, and carried by 110 million European men. Previous studies suggested a Paleolithic origin, but here we show that the geographical distribution of its microsatellite diversity is best explained by spread from a single source in the Near East via Anatolia during the Neolithic. Taken with evidence on the origins of other haplogroups, this indicates that most European Y chromosomes originate in the Neolithic expansion. This reinterpretation makes Europe a prime example of how technological and cultural change is linked with the expansion of a Y-chromosomal lineage, and the contrast of this pattern with that shown by maternally inherited mitochondrial DNA suggests a unique role for males in the transition.

  5. The European Hematology Association Roadmap for European Hematology Research: a consensus document.

    PubMed

    Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

    2016-02-01

    The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap.The EHA Roadmap identifies nine 'sections' in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders.The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.

  6. The European Hematology Association Roadmap for European Hematology Research: a consensus document

    PubMed Central

    Engert, Andreas; Balduini, Carlo; Brand, Anneke; Coiffier, Bertrand; Cordonnier, Catherine; Döhner, Hartmut; de Wit, Thom Duyvené; Eichinger, Sabine; Fibbe, Willem; Green, Tony; de Haas, Fleur; Iolascon, Achille; Jaffredo, Thierry; Rodeghiero, Francesco; Salles, Gilles; Schuringa, Jan Jacob

    2016-01-01

    The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients. PMID:26819058

  7. European Conference on Health Economics.

    PubMed

    Malmivaara, Antti

    2010-12-01

    The biennial European Conference on Health Economics was held in Finland this year, at the Finlandia Hall in the centre of Helsinki. The European conferences rotate among European countries and fall between the biennial world congresses organized by the International Health Economics Association (iHEA). A record attendance of approximately 800 delegates from 50 countries around the world were present at the Helsinki conference. The theme of the conference was 'Connecting Health and Economics'. All major topics of health economics were covered in the sessions. For the first time, social care economics was included in the agenda of the European Conference as a session of its own.

  8. A New Impetus for European Youth. European Commission White Paper.

    ERIC Educational Resources Information Center

    Commission of the European Communities, Brussels (Belgium).

    Despite their highly divergent situations, young people largely share the same values, ambitions, and difficulties. Despite the more complex social and economic context in which young Europeans are currently living, they are well equipped to adapt. National and European policymakers must facilitate this process of change by making young people…

  9. European Cenozoic rift system

    NASA Astrophysics Data System (ADS)

    Ziegler, Peter A.

    1992-07-01

    The European Cenozoic rift system extends from the coast of the North Sea to the Mediterranean over a distance of some 1100 km; it finds its southern prolongation in the Valencia Trough and a Plio-Pleistocene volcanic chain crossing the Atlas ranges. Development of this mega-rift was paralleled by orogenic activity in the Alps and Pyrenees. Major rift domes, accompanied by subsidence reversal of their axial grabens, developed 20-40 Ma after beginning of rifting. Uplift of the Rhenish Shield is related to progressive thermal lithospheric thinning; the Vosges-Black Forest and the Massif Central domes are probably underlain by asthenoliths emplaced at the crust/mantle boundary. Evolution of this rift system, is thought to be governed by the interaction of the Eurasian and African plates and by early phases of a plate-boundary reorganization that may lead to the break-up of the present continent assembly.

  10. Optranet: a European project

    NASA Astrophysics Data System (ADS)

    Jeanjean, Marie

    2003-10-01

    In a situation where curricula did not adjust at the required pace and many students are getting attracted out of science and technology, the shortage of skilled workers at the technician and engineer level is known to be a threat to development. In spite of a serious crisis in 2001, the trend of an increased presence of optical technologies remains unchanged and is bound to remain part of the landscape for decades. The level of investment required and the markets make Europe the best scale to plan for unified curricula and a global analysis of the human resources needs. There is no agreement on the definition of a trained optician, and European countries differ in the way they educate opticians, source of a lack of clarity and visibility which is detrimental to attracting good students and to the job market. Through its closely work with companies, OPTRANET will propose measures to enhance the adequacy and the visibility of the training offer.

  11. The European Register of Microform Masters--Supporting International Cooperation.

    ERIC Educational Resources Information Center

    Schwartz, Werner

    With almost every country in the world doing costly microfilming to preserve the world's printed heritage, it is essential to find a way by which these vast stores of information are not knowingly duplicated. A significant contribution to this effort has been the establishment of the European Register of Microform Masters (EROMM), a shared…

  12. Income and Well-Being across European Provinces

    ERIC Educational Resources Information Center

    Okulicz-Kozaryn, Adam

    2012-01-01

    The majority of studies investigate the effect of income on life satisfaction at either individual or country level. This study contributes with analysis at the (sub-national) province level across West European countries. I use a unique dataset Eurobarometer 44.2 Bis that is representative of province populations in a multilevel model. Provinces…

  13. Erasmus Student Mobility and the Construction of European Citizenship

    ERIC Educational Resources Information Center

    Llurda, Enric; Gallego-Balsà, Lídia; Barahona, Clàudia; Martin-Rubió, Xavier

    2016-01-01

    The Erasmus student mobility programme allocates three explicit objectives to the experience of spending a few months studying in another European country: (1) to benefit students educationally, linguistically and culturally; (2) to promote co-operation between institutions and (3) to contribute to the development of a pool of well-qualified,…

  14. A Case of Cooperation in the European OR Education

    ERIC Educational Resources Information Center

    Miranda, Joao; Nagy, Mariana

    2011-01-01

    European cooperation is a relevant subject that contributes to building a competitive network of high education institutions. A case of teacher mobility on behalf of the Erasmus programme is presented: it considers some Operations Research topics and the development of the Lego on My Decision module. The module considers eight lecture hours in…

  15. Educating European Citizenship: Elucidating Assumptions about Teaching Civic Competence

    ERIC Educational Resources Information Center

    Bengtsson, Anki

    2015-01-01

    In recent years, the idea of the contribution of education to citizenship has been reinitiated. The purpose of this paper is to investigate constructions of citizenship as they are articulated in European policy documents on teacher education. It is indicated that the normative form of active citizenship is put into play through the individual and…

  16. Fifty Years of the European Convention on Human Rights.

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France).

    This booklet is intended as the nongovernmental organization's (NGO's) contribution to the celebration of the 50th anniversary of the European Convention on Human Rights (ECHR). Its aim is to bear witness to the commitment of the NGOs having consultative status with the Council of Europe, and to all that they have done to make known, put into…

  17. The European Register of Microform Masters--Supporting International Cooperation.

    ERIC Educational Resources Information Center

    Schwartz, Werner

    With almost every country in the world doing costly microfilming to preserve the world's printed heritage, it is essential to find a way by which these vast stores of information are not knowingly duplicated. A significant contribution to this effort has been the establishment of the European Register of Microform Masters (EROMM), a shared…

  18. The European Entrepreneurial University: An Alternative to the US Model.

    ERIC Educational Resources Information Center

    Etzkowitz, Henry

    2003-01-01

    The European entrepreneurial university is typically based on the teaching mission, the U.S. on the research mission. Given similar goals of contributing to regional development and return on research investment, each may adopt the other's style over time. (Contains 21 references.) (SK)

  19. Fifty Years of the European Convention on Human Rights.

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France).

    This booklet is intended as the nongovernmental organization's (NGO's) contribution to the celebration of the 50th anniversary of the European Convention on Human Rights (ECHR). Its aim is to bear witness to the commitment of the NGOs having consultative status with the Council of Europe, and to all that they have done to make known, put into…

  20. Erasmus Student Mobility and the Construction of European Citizenship

    ERIC Educational Resources Information Center

    Llurda, Enric; Gallego-Balsà, Lídia; Barahona, Clàudia; Martin-Rubió, Xavier

    2016-01-01

    The Erasmus student mobility programme allocates three explicit objectives to the experience of spending a few months studying in another European country: (1) to benefit students educationally, linguistically and culturally; (2) to promote co-operation between institutions and (3) to contribute to the development of a pool of well-qualified,…

  1. A European Perspective on Kinesiology in the 21st Century

    ERIC Educational Resources Information Center

    Bardy, Benoit G.

    2008-01-01

    A collection of information about kinesiology around the world is given in this article. Institutions, societies, and journals that have contributed to the emergence of the field are indicated to illustrate the richness of current places where research on movement is conducted. The particular case of kinesiology in the European Union is detailed.…

  2. A Case of Cooperation in the European OR Education

    ERIC Educational Resources Information Center

    Miranda, Joao; Nagy, Mariana

    2011-01-01

    European cooperation is a relevant subject that contributes to building a competitive network of high education institutions. A case of teacher mobility on behalf of the Erasmus programme is presented: it considers some Operations Research topics and the development of the Lego on My Decision module. The module considers eight lecture hours in…

  3. Income and Well-Being across European Provinces

    ERIC Educational Resources Information Center

    Okulicz-Kozaryn, Adam

    2012-01-01

    The majority of studies investigate the effect of income on life satisfaction at either individual or country level. This study contributes with analysis at the (sub-national) province level across West European countries. I use a unique dataset Eurobarometer 44.2 Bis that is representative of province populations in a multilevel model. Provinces…

  4. Satisfaction with Job and Income among Older Individuals across European Countries

    ERIC Educational Resources Information Center

    Bonsang, Eric; van Soest, Arthur

    2012-01-01

    Using data on individuals of age 50 and older from 11 European countries, we analyze two economic aspects of subjective well-being of older Europeans: satisfaction with household income, and job satisfaction. Both have been shown to contribute substantially to overall well-being (satisfaction with life or happiness). We use anchoring vignettes to…

  5. The Changing Frontiers of Comparative Education: A Forty-Year Retrospective on "European Education"

    ERIC Educational Resources Information Center

    Silova, Iveta

    2009-01-01

    "European Education" (originally known as "Western European Education") may no longer be directly associated with the field of comparative and international education, yet its establishment in 1969 was an attempt to make a direct contribution to the academic debates about the future of comparative education. The journal emerged…

  6. Educational Research: What Strategies for Development in the European Research Area?

    ERIC Educational Resources Information Center

    Brown, Alan

    2004-01-01

    This is a report of the "European Educational Research Journal" (EERJ) Roundtable that sought to describe what national educational research programmes are doing, how they are working together, and how they might contribute to the developing European Educational Research Space. The Roundtable was an opportunity for one large consortium…

  7. The European Teacher: Transnational Perspectives in Teacher Education Policy and Practice

    ERIC Educational Resources Information Center

    Schratz, Michael

    2014-01-01

    The future role of teachers in Europe will contribute to raising the awareness of a new expectation of what it means to be a "European Teacher". If there is unity in diversity through national identities, the question remains: what makes a teacher "European"? Answering this unusual question, one encounters several aspects that…

  8. Satisfaction with Job and Income among Older Individuals across European Countries

    ERIC Educational Resources Information Center

    Bonsang, Eric; van Soest, Arthur

    2012-01-01

    Using data on individuals of age 50 and older from 11 European countries, we analyze two economic aspects of subjective well-being of older Europeans: satisfaction with household income, and job satisfaction. Both have been shown to contribute substantially to overall well-being (satisfaction with life or happiness). We use anchoring vignettes to…

  9. The Changing Frontiers of Comparative Education: A Forty-Year Retrospective on "European Education"

    ERIC Educational Resources Information Center

    Silova, Iveta

    2009-01-01

    "European Education" (originally known as "Western European Education") may no longer be directly associated with the field of comparative and international education, yet its establishment in 1969 was an attempt to make a direct contribution to the academic debates about the future of comparative education. The journal emerged…

  10. The European Dimension in Education.

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France). Directorate of Education, Culture and Sport, Documentation Section.

    This paper addresses concerns about a European dimension in education that has been created by the enlargement of the European Union (EU) (the inclusion of Austria, Finland, and Sweden) and the gradual transformations of institutions into a future federal state. Sections of the paper include: (1) "Introduction"; (2) "Defining the…

  11. European urology: quality, impact, online.

    PubMed

    Catto, James W F; Montorsi, Francesco; Schulman, Claude

    2013-10-01

    European Urology provides contemporary, cutting-edge urologic research, guidance, and discussion. The journal continues to invite collaborative reviews, to invest in rapid but fair peer review, to seek the best research, and to serve the needs of readers and patients. Copyright © 2013 European Association of Urology. Published by Elsevier B.V. All rights reserved.

  12. The European Dimension in Education.

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France). Directorate of Education, Culture and Sport, Documentation Section.

    This paper addresses concerns about a European dimension in education that has been created by the enlargement of the European Union (EU) (the inclusion of Austria, Finland, and Sweden) and the gradual transformations of institutions into a future federal state. Sections of the paper include: (1) "Introduction"; (2) "Defining the…

  13. What Audience for European Television?

    ERIC Educational Resources Information Center

    Wendelbo, Harald Arni

    This discussion of the audience for European television argues that satellite television has taken an upside-down approach, i.e., it has begun by focusing on the hardware, and then the software, before checking to see if there would be a user at the end of the line willing to pay for the whole operation. "European television" is then…

  14. Brazilian Portuguese Ethnonymy and Europeanisms.

    ERIC Educational Resources Information Center

    Stephens, Thomas M.

    1994-01-01

    Delineates the incorporation and analyzes the impact of European borrowings in Brazilian racio-ethnic terminology. This overview covers French, Italian, Spanish, and English influences. Borrowings from European languages have had a small impact on the calculus of Brazilian racio-ethnic terms. (43 references) (Author/CK)

  15. A European Humus Forms Reference Base

    NASA Astrophysics Data System (ADS)

    Zanella, A.; Englisch, M.; Ponge, J.-F.; Jabiol, B.; Sartori, G.; Gardi, C.

    2012-04-01

    From 2003 on, a panel of experts in humus and humus dynamics (Humus group) has been working about a standardisation and improvement of existing national humus classifications. Some important goals have been reached, in order to share data and experiences: a) definition of specific terms; b) description of 15 types of diagnostic horizons; c) of 10 basic humus forms references; d) subdivision of each main reference in 2-4 sub-unities; e) elaboration of a general European Humus Form Reference Base (http://hal-agroparistech.archives-ouvertes.fr/docs/00/56/17/95/PDF/Humus_Forms_ERB_31_01_2011.pdf); f) publication of the scientific significance of this base of classification as an article [A European morpho-functional classification of humus forms. Geoderma, 164 (3-4), 138-145]. The classification will be updated every 2 years and presently the Humus group is assessing biological (general: soil, vegetation, biome; specific: fungi, bacteria, pedofauna), physical (air temperature, rainfall) and chemical (pH, mineral elements, organic matter, quality and quantity of humic components…) factors which characterize basic humus forms and their varieties. The content of the new version of the classification is planned to be more "practical", like an ecological manual which lists associated humus forms and environmental data in the aim to contribute to a more precise environmental diagnosis of every analysed terrestrial and semiterrestrial European ecosystem. The Humus group is also involved in an endeavour to include humus forms in the World Reference Base for Soils (WRB-FAO) according to nomenclatural principles erected for soil profiles. Thirty basic references have been defined, complemented by a set of qualifiers (prefixes and suffixes), allowing to classify European humus forms and probably a large majority of humus forms known worldwide. The principles of the classification, the diagnostic horizons and humus forms main references are presented at the General Assembly of

  16. An American Construction of European Education Space

    ERIC Educational Resources Information Center

    Silova, Iveta; Brehm, William C.

    2010-01-01

    The construction of the European education space has typically been attributed to European education policy makers, institutions, and networks. Rarely do scholars consider the role of outside, non-European actors in shaping the terrain of European education thought and practice. This article considers the construction of the European education…

  17. An American Construction of European Education Space

    ERIC Educational Resources Information Center

    Silova, Iveta; Brehm, William C.

    2010-01-01

    The construction of the European education space has typically been attributed to European education policy makers, institutions, and networks. Rarely do scholars consider the role of outside, non-European actors in shaping the terrain of European education thought and practice. This article considers the construction of the European education…

  18. Vascular surgery: the European perspective.

    PubMed

    Harris, P

    1999-09-01

    Isaac Newton, among others, observed that 'we see so far because we are standing upon the shoulders of giants'. In vascular surgery most of the giants have been European, and this is a heritage which we as Europeans can take pride in and build upon if we chose to do so. As in other areas of life, commitment is essential in order to influence the future. For vascular surgeons in Europe this means active participation in the European scientific societies for vascular surgery and in the UEMS. The main value of the EBSQ.VASC assessments to date has been to expose the uneven standards of training in vascular surgery within the European Union. Only if action follows to address these inequalities will the tactics of the European Board of Vascular Surgery be vindicated.

  19. The European seismological waveform framework EIDA

    NASA Astrophysics Data System (ADS)

    Trani, Luca; Koymans, Mathijs; Quinteros, Javier; Heinloo, Andres; Euchner, Fabian; Strollo, Angelo; Sleeman, Reinoud; Clinton, John; Stammler, Klaus; Danecek, Peter; Pedersen, Helle; Ionescu, Constantin; Pinar, Ali; Evangelidis, Christos

    2017-04-01

    The ORFEUS1 European Integrated Data Archive (EIDA2) federates (currently) 11 major European seismological data centres into a common organisational and operational framework which offers: (a) transparent and uniform access tools, advanced services and products for seismological waveform data; (b) a platform for establishing common policies for the curation of seismological waveform data and the description of waveform data by standardised quality metrics; (c) proper attribution and citation (e.g. data ownership). After its establishment in 2013, EIDA has been collecting and distributing seamlessly large amounts of seismological data and products to the research community and beyond. A major task of EIDA is the on-going improvement of the services, tools and products portfolio in order to meet the increasingly demanding users' requirements. At present EIDA is entering a new operational phase and will become the reference infrastructure for seismological waveform data in the pan-European infrastructure for solid-Earth science: EPOS (European Plate Observing System)3. The EIDA Next Generation developments, initiated within the H2020 project EPOS-IP, will provide a new infrastructure that will support the seismological and multidisciplinary EPOS community facilitating interoperability in a broader context. EIDA NG comprises a number of new services and products e.g.: Routing Service, Authentication Service, WFCatalog, Mediator, Station Book and more in the near future. In this contribution we present the current status of the EIDA NG developments and provide an overview of the usage of the new services and their impact on the user community. 1 www.orfeus-eu.org/ 2 www.orfeus-eu.org/eida/eida.html 3 www.epos-ip.org

  20. European Citizenship and European Union Expansion: Perspectives on Europeanness and Citizenship Education from Britain and Turkey

    ERIC Educational Resources Information Center

    Wilkins, Chris; Busher, Hugh; Lawson, Tony; Acun, Ismail; Goz, Nur Leman

    2010-01-01

    This article discusses some perspectives on citizenship education in Turkey and Britain in the context of current contested discourses on the nature of European identity and of the European Union (EU). It is based on data collected during an EU-funded student teacher exchange programme between three universities in Turkey and Leicester University…

  1. The European Narcolepsy Network (EU-NN) database.

    PubMed

    Khatami, Ramin; Luca, Gianina; Baumann, Christian R; Bassetti, Claudio L; Bruni, Oliviero; Canellas, Francesca; Dauvilliers, Yves; Del Rio-Villegas, Rafael; Feketeova, Eva; Ferri, Raffaele; Geisler, Peter; Högl, Birgit; Jennum, Poul; Kornum, Birgitte R; Lecendreux, Michel; Martins-da-Silva, Antonio; Mathis, Johannes; Mayer, Geert; Paiva, Teresa; Partinen, Markku; Peraita-Adrados, Rosa; Plazzi, Guiseppe; Santamaria, Joan; Sonka, Karel; Riha, Renata; Tafti, Mehdi; Wierzbicka, Aleksandra; Young, Peter; Lammers, Gert Jan; Overeem, Sebastiaan

    2016-06-01

    Narcolepsy with cataplexy is a rare disease with an estimated prevalence of 0.02% in European populations. Narcolepsy shares many features of rare disorders, in particular the lack of awareness of the disease with serious consequences for healthcare supply. Similar to other rare diseases, only a few European countries have registered narcolepsy cases in databases of the International Classification of Diseases or in registries of the European health authorities. A promising approach to identify disease-specific adverse health effects and needs in healthcare delivery in the field of rare diseases is to establish a distributed expert network. A first and important step is to create a database that allows collection, storage and dissemination of data on narcolepsy in a comprehensive and systematic way. Here, the first prospective web-based European narcolepsy database hosted by the European Narcolepsy Network is introduced. The database structure, standardization of data acquisition and quality control procedures are described, and an overview provided of the first 1079 patients from 18 European specialized centres. Due to its standardization this continuously increasing data pool is most promising to provide a better insight into many unsolved aspects of narcolepsy and related disorders, including clear phenotype characterization of subtypes of narcolepsy, more precise epidemiological data and knowledge on the natural history of narcolepsy, expectations about treatment effects, identification of post-marketing medication side-effects, and will contribute to improve clinical trial designs and provide facilities to further develop phase III trials.

  2. The European mesothelioma epidemic

    PubMed Central

    Peto, J; Decarli, A; Vecchia, C La; Levi, F; Negri, E

    1999-01-01

    Projections for the period 1995–2029 suggest that the number of men dying from mesothelioma in Western Europe each year will almost double over the next 20 years, from 5000 in 1998 to about 9000 around 2018, and then decline, with a total of about a quarter of a million deaths over the next 35 years. The highest risk will be suffered by men born around 1945–50, of whom about 1 in 150 will die of mesothelioma. Asbestos use in Western Europe remained high until 1980, and substantial quantities are still used in several European countries. These projections are based on the fit of a simple age and birth cohort model to male pleural cancer mortality from 1970 to 1989 for six countries (Britain, France, Germany, Italy, The Netherlands and Switzerland) which together account for three-quarters of the population of Western Europe. The model was tested by comparing observed and predicted numbers of deaths for the period 1990–94. The ratio of mesothelioma to recorded pleural cancer mortality has been 1.6:1 in Britain but was assumed to be 1:1 in other countries. © 1999 Cancer Research Campaign PMID:10027347

  3. European Union energy policy integration: A case of European Commission policy entrepreneurship and increasing supranationalism.

    PubMed

    Maltby, Tomas

    2013-04-01

    Focusing on gas, this article explores the role of the European Commission in the process of European Union energy security policy development, and the extent to which the policy area is becoming increasingly supranational. Situating the article within the literature on agenda-setting and framing, it is argued that a policy window was opened as a result of: enlargement to include more energy import dependent states, a trend of increasing energy imports and prices, and gas supply disruptions. From the mid-2000s, the Commission contributed to a shift in political norms, successfully framing import dependency as a problem requiring an EU-level solution, based on the institution's pre-existing preferences for a diversified energy supply and internal energy market. Whilst Member States retain significant sovereignty, the Commission has achieved since 2006 creeping competencies in the internal, and to a lesser extent external, dimensions of EU energy policy.

  4. European Union energy policy integration: A case of European Commission policy entrepreneurship and increasing supranationalism

    PubMed Central

    Maltby, Tomas

    2013-01-01

    Focusing on gas, this article explores the role of the European Commission in the process of European Union energy security policy development, and the extent to which the policy area is becoming increasingly supranational. Situating the article within the literature on agenda-setting and framing, it is argued that a policy window was opened as a result of: enlargement to include more energy import dependent states, a trend of increasing energy imports and prices, and gas supply disruptions. From the mid-2000s, the Commission contributed to a shift in political norms, successfully framing import dependency as a problem requiring an EU-level solution, based on the institution’s pre-existing preferences for a diversified energy supply and internal energy market. Whilst Member States retain significant sovereignty, the Commission has achieved since 2006 creeping competencies in the internal, and to a lesser extent external, dimensions of EU energy policy. PMID:24926115

  5. Intellectual property and biotechnology: the European debate.

    PubMed

    Brody, Baruch

    2007-06-01

    The European patent system allows for the introduction of moral issues into decisions about the granting of patents. This feature has greatly impacted European debates about the patenting of biotechnology. This essay explores the European experience, in both the European Union and the European Patent Organization. It argues that there has been great confusion surrounding these issues primarily because the Europeans have not developed a general theory about when exclusion from patentability is the best social mechanism for dealing with morally offensive technologies.

  6. Special Issue: European Conference on Surface Science 2014

    NASA Astrophysics Data System (ADS)

    Opila, Robert L.; Ertas, Gulay

    2015-11-01

    The present Special Issue of Applied Surface Science is intended to provide a collection of peer-reviewed contributions presented at the Symposium "European Conference on Surface Science" held in Antalya (Turkey), August 31-September 5, 2014. This conference is organized annually through the joint efforts of the Surface Science Division of IUVSTA and the Surface and Interface Section of the European Physical Society (EPS). The ECOSS conference series started in 1978 in Amsterdam, Netherlands, and has been held in various cities throughout Europe during the past years. This is the first time that an ECOSS conference was held in Turkey, with the chairmanship of Prof. Sefik Suzer of Bilkent University, Ankara.

  7. North European Transect

    NASA Astrophysics Data System (ADS)

    Korja, Annakaisa; Heikkinen, Pekka J.; Roslov, Yuri; Ivanova, Nina; Verba, Marc; Sakoulina, Tamara

    2010-05-01

    A nearly continuous, 3600 km long, NE-running North European Transect (NET) is combined from the existing deep seismic reflection data sets in the Baltic Sea (BABEL, 1600 km), Northern Finland (FIRE 4-4A, 580 km) and Barents Sea (1-AR, 1440 km;). The reflective image of the deep crust is highly dependent on the thickness of the sedimentary cover. The cover is few hundred meters in the Baltic sea, few tens of meters in the land areas and few kilometers in the Barents Sea area. In the Barents Sea area, the seismic image is dominated by the layered structure of the sedimentary basins and the middle and lower crust are poorly imaged. Therefore the Moho boundary in the Barents Sea has been determined from wide-angle reflections. Geologically the transect covers the transition from Phanerozoic Europe to Precambrian Europe and back to the Phanerozoic Barents Sea Shelf. It displays how Northern Europe grew around Baltica in several tectonic episodes involving the formation and destruction of Columbia/Hudsonland, Rodinia and Pangea supercontinents. The paleo plateboundaries are traversed by subvertical transparent zones suggesting transpressional and trantensional environments. The BABEL lines image how the core of Baltica was formed by sequential accretion of microcontinents and arc terranes at the old continental margin during the Svecofennian Orogeny ~1.9-1.8 Ga .When Baltica joined the Columbia supercontinent, new terranes were added to its southern edge in the Sveocbaltic Orogeny (~1.8 Ga). During the dispersal of the Columbia, the Baltic Sea failed rift was formed, rapakivi granitoids were intruded and sedimentary basins were developed. An extended plate margin structure has been imposed on the Rodinian (Sveconorwegian) and Pangean additions (Variscan-Caledonian). Major crustal thinning takes place along a series of subvertical faults across the Trans-European Suture Zone marking the transition from Phanerozoic to Proterozoic Europe. The FIRE lines in Northen Finland

  8. European MEMS foundries

    NASA Astrophysics Data System (ADS)

    Salomon, Patric R.

    2003-01-01

    According to the latest release of the NEXUS market study, the market for MEMS or Microsystems Technology (MST) is predicted to grow to $68B by the year 2005, with systems containing these components generating even higher revenues and growth. The latest advances in MST/MEMS technology have enabled the design of a new generation of microsystems that are smaller, cheaper, more reliable, and consume less power. These integrated systems bring together numerous analog/mixed signal microelectronics blocks and MEMS functions on a single chip or on two or more chips assembled within an integrated package. In spite of all these advances in technology and manufacturing, a system manufacturer either faces a substantial up-front R&D investment to create his own infrastructure and expertise, or he can use design and foundry services to get the initial product into the marketplace fast and with an affordable investment. Once he has a viable product, he can still think about his own manufacturing efforts and investments to obtain an optimized high volume manufacturing for the specific product. One of the barriers to successful exploitation of MEMS/MST technology has been the lack of access to industrial foundries capable of producing certified microsystems devices in commercial quantities, including packaging and test. This paper discusses Multi-project wafer (MPW) runs, requirements for foundries and gives some examples of foundry business models. Furthermore, this paper will give an overview on MST/MEMS services that are available in Europe, including pure commercial activities, European project activities (e.g. Europractice), and some academic services.

  9. European eye bank association.

    PubMed

    Jones, Gary L A; Ponzin, Diego; Pels, Elisabeth; Maas, Hanneke; Tullo, Andrew B; Claerhout, Ilse

    2009-01-01

    The European Eye Bank Association (EEBA) is a technical-scientific organization for eye banks. Founded in 1989 with the simple objective of sharing information on eye banking, the Association is today the leading pan-national association in Europe dedicated to the advancement of eye banking and an authoritative reference point for eye banks which work according to quality standards. The Association establishes and maintains an agreed set of medical and technical standards, promotes the collection of data on eye bank activities and processes, provides opportunities for the discussion of all aspects of eye banking practice, including eye donor selection and procurement, relevant research and development, education and training in eye banking, and maintains linkage with national and international corneal transplant communities and relevant bodies. The recent introduction of a more structured and focused committee, a permanent secretariat, the development of a website has enabled the Association to establish closer links and collaborative activities with key regulatory bodies and to provide a more constant exchange of clinical, scientific and technical ideas and best practice with fellow professionals by means of its annual meetings, the EEBA directory and website, and a regular newsletter. The EEBA is a scientific organization committed to defining minimum standards and to encouraging eye banks to maintain the highest possible standards for quality and safety. Through its annual meetings, and the collection and exchange of detailed information from member eye banks, the Association can rightly claim to speak with a confident and representative voice on eye banking in Europe. Copyright 2009 S. Karger AG, Basel.

  10. Gender differences in ancestral contribution and admixture in Venezuelan populations.

    PubMed

    Guerra, D Castro De; Pérez, C Figuera; Izaguirre, M H; Barahona, E Arroyo; Larralde, A Rodríguez; Lugo, M Vívenes De

    2011-06-01

    The origin of the contribution of uniparental heritage were analyzed in 615 samples of individuals proceeding from 13 towns classified according to historic differences in their emergence and development as African-derived, European-derived, and admixed/urban. Mitochondrial and Y-chromosome haplogroups were identified by PCR-restriction fragment length polymorphism. The results were compared with previous estimates of admixture made with autosomal markers and with historic aspects. The results show a predominantly indigenous genetic contribution through the female, being more prevalent in urban populations; the African contribution, although dispersed, presents a larger concentration in the African-derived towns, whereas the European contribution is limited to populations with this origin, reflecting isolation and the conservation of the distribution pattern of genes of the Colonial era. With regard to admixture through males, it is almost exclusively of European origin, whereas the African contribution is basically concentrated in the African-derived towns, and the Amerindian lineages are almost nonexistent. The genome of paternal heredity, as opposed to the autosomal and the mitochondrial, shows a homogeneous pattern of admixture that is independent of the origin of the population studied, suggesting that European genes have been introduced into the Venezuelan population through male immigrations, whereas the indigenous contribution has been preserved in the Venezuelan genetic pool through the women. These results provide evidence of the heterogeneity in the genetic origin of the Venezuelan population, which should be taken into account in forensic and epidemiologic genetic studies.

  11. Ancient human genomes suggest three ancestral populations for present-day Europeans

    PubMed Central

    Lazaridis, Iosif; Patterson, Nick; Mittnik, Alissa; Renaud, Gabriel; Mallick, Swapan; Kirsanow, Karola; Sudmant, Peter H.; Schraiber, Joshua G.; Castellano, Sergi; Lipson, Mark; Berger, Bonnie; Economou, Christos; Bollongino, Ruth; Fu, Qiaomei; Bos, Kirsten I.; Nordenfelt, Susanne; Li, Heng; de Filippo, Cesare; Prüfer, Kay; Sawyer, Susanna; Posth, Cosimo; Haak, Wolfgang; Hallgren, Fredrik; Fornander, Elin; Rohland, Nadin; Delsate, Dominique; Francken, Michael; Guinet, Jean-Michel; Wahl, Joachim; Ayodo, George; Babiker, Hamza A.; Bailliet, Graciela; Balanovska, Elena; Balanovsky, Oleg; Barrantes, Ramiro; Bedoya, Gabriel; Ben-Ami, Haim; Bene, Judit; Berrada, Fouad; Bravi, Claudio M.; Brisighelli, Francesca; Busby, George B. J.; Cali, Francesco; Churnosov, Mikhail; Cole, David E. C.; Corach, Daniel; Damba, Larissa; van Driem, George; Dryomov, Stanislav; Dugoujon, Jean-Michel; Fedorova, Sardana A.; Romero, Irene Gallego; Gubina, Marina; Hammer, Michael; Henn, Brenna M.; Hervig, Tor; Hodoglugil, Ugur; Jha, Aashish R.; Karachanak-Yankova, Sena; Khusainova, Rita; Khusnutdinova, Elza; Kittles, Rick; Kivisild, Toomas; Klitz, William; Kučinskas, Vaidutis; Kushniarevich, Alena; Laredj, Leila; Litvinov, Sergey; Loukidis, Theologos; Mahley, Robert W.; Melegh, Béla; Metspalu, Ene; Molina, Julio; Mountain, Joanna; Näkkäläjärvi, Klemetti; Nesheva, Desislava; Nyambo, Thomas; Osipova, Ludmila; Parik, Jüri; Platonov, Fedor; Posukh, Olga; Romano, Valentino; Rothhammer, Francisco; Rudan, Igor; Ruizbakiev, Ruslan; Sahakyan, Hovhannes; Sajantila, Antti; Salas, Antonio; Starikovskaya, Elena B.; Tarekegn, Ayele; Toncheva, Draga; Turdikulova, Shahlo; Uktveryte, Ingrida; Utevska, Olga; Vasquez, René; Villena, Mercedes; Voevoda, Mikhail; Winkler, Cheryl; Yepiskoposyan, Levon; Zalloua, Pierre; Zemunik, Tatijana; Cooper, Alan; Capelli, Cristian; Thomas, Mark G.; Ruiz-Linares, Andres; Tishkoff, Sarah A.; Singh, Lalji; Thangaraj, Kumarasamy; Villems, Richard; Comas, David; Sukernik, Rem; Metspalu, Mait; Meyer, Matthias; Eichler, Evan E.; Burger, Joachim; Slatkin, Montgomery; Pääbo, Svante; Kelso, Janet; Reich, David; Krause, Johannes

    2014-01-01

    We sequenced the genomes of a ~7,000 year old farmer from Germany and eight ~8,000 year old hunter-gatherers from Luxembourg and Sweden. We analyzed these and other ancient genomes1–4 with 2,345 contemporary humans to show that most present Europeans derive from at least three highly differentiated populations: West European Hunter-Gatherers (WHG), who contributed ancestry to all Europeans but not to Near Easterners; Ancient North Eurasians (ANE) related to Upper Paleolithic Siberians3, who contributed to both Europeans and Near Easterners; and Early European Farmers (EEF), who were mainly of Near Eastern origin but also harbored WHG-related ancestry. We model these populations’ deep relationships and show that EEF had ~44% ancestry from a “Basal Eurasian” population that split prior to the diversification of other non-African lineages. PMID:25230663

  12. [Establishing ophthalmology in the research framework programs of the European Union].

    PubMed

    Scholl, H P N; Wheeler-Schilling, T H; Zrenner, E; Holz, F G

    2006-02-01

    The framework programmes (FP) of the European Commission have substantially contributed to the funding of research within the European countries. The contribution of the funding provided by the EU relative to the funding available on the national level has steadily increased. European ophthalmology and vision research has benefited from this support provided by the EU. This review introduces the European funding policies and the European Research Area (ERA) and provides a list of all projects in ophthalmology and vision research that have been funded within FP1 to FP6. As an example for new instruments within FP6, Integrated Projects, the EVI-GENORET project is introduced. Finally an outlook for FP7 is provided.

  13. European strategies for mental health.

    PubMed

    Di Fiandra, Teresa

    2009-01-01

    The most recent developments of strategies and policies in the mental health field in Europe are related to the World Health Organization (WHO) Declaration and Action Plan on Mental Health signed by all the Ministers of Health of all Member States in the European Region (2005). The Action Plan proposes ways and means of developing comprehensive mental health policies, listing 12 areas in which challenges are indicated and detailed actions are required. Afterwards the Green Paper on Mental Health has been launched by the European Commission for the definition of an European strategy. The more precise European Pact for Mental Health and Well-being has been presented in 2008. Many other international bodies (OECD, Council of Europe, etc.) have actively worked to stress the mental health issue. All are clearly referring to the Italian model, started 30 years ago.

  14. Commissioning for the European XFEL facility

    NASA Astrophysics Data System (ADS)

    Nölle, D.

    2017-06-01

    The European XFEL is a 4th generation light source based on the Self Amplified Spontaneous Emission (SASE) FreeElectron-Laser concept. It is currently being commissioned in North- Germany. The core installation is a 17.5 GeV superconducting accelerator driving 3 SASE lines with photon energies from 1 to beyond 20 keV range with a maximum of 27.000 pulses per second. The international facility is organized as a limited liability company with shareholders from the contributing countries. DESY has taken over the leadership of the accelerator construction consortium, and will be in charge of the operation of the accelerator complex. The facility was set up with contributions from the 11 shareholder countries, either being hardware systems and/or staff or cash contributions. The construction is almost complete, and the commissioning phase has started by the end of 2015. This contribution will report the status of the accelerator complex with emphasis on the commissioning of the accelerator and an outlook to the commissioning of the SASE 1 FEL line.

  15. PREFACE: 5th European Conference on Neutron Scattering

    NASA Astrophysics Data System (ADS)

    Mikula, Pavel; Hlinka, Jiří; Prokeš, Karel; Dohnálek, Jan; Šittner, Petr; Javorský, Pavel

    2012-02-01

    This volume contains proceedings of ECNS 2011, held in Prague, Czech Republic, 17-22 July 2011. ECNS 2011 was the fifth Conference in a series of meetings organized in various European cities under patronage of the European Neutron Scattering Association, and was preceded by the European Neutron Scattering Conferences in Interlaken (1996), Budapest (1999), Montpellier (2003) and Lund (2007). The positive atmosphere of the Prague meeting of the neutron community can certainly be attributed to recent progress in the extension of the European neutron experimental base, in particular the completion of the ISIS second target station and considerable progress in the European Spallation Source project in Lund. The success of ECNS 2011 has been manifested by the participation of 698 scientists from 36 countries, who presented 231 talks and 534 posters. This proceedings contains 112 papers from authors who wished to have the written versions of their contributions published. The contributions illustrate the broad scale of scientific problems investigated by neutron scattering methods and give a picture of growing activities in the field. The conference chairmen wish to express their thanks to all colleagues who contributed to the organization and preparation of ECNS 2011, in particular the members of the International Advisory Committee, the International Program Committee and the Local Organizing Committee. We very much appreciate the role of Professor Michael Steiner, the President of ENSA, and all ENSA representatives who contributed valuable conceptual input and advice in the preparatory phase of the conference organization. Special thanks go to the editors and all the referees who helped us to publish the ECNS 2011 Proceedings in such a short time. Vladimír SechovskýPetr Lukáš Conference chairmen The PDF contains photographs from the conference and a full list of participants.

  16. KENNEDY SPACE CENTER, FLA. - International Space Station elements being processed for launch on upcoming Space Shuttle flights, including the Japanese Experiment Module (JEM) pressurized module (Kibo or Hope) and the U.S. Node 2, line the walls of the high bay in the Space Station Processing Facility. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The JEM pressurized module arrived at KSC on June 4. It is Japan's primary contribution to the Station.

    NASA Image and Video Library

    2003-06-19

    KENNEDY SPACE CENTER, FLA. - International Space Station elements being processed for launch on upcoming Space Shuttle flights, including the Japanese Experiment Module (JEM) pressurized module (Kibo or Hope) and the U.S. Node 2, line the walls of the high bay in the Space Station Processing Facility. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The JEM pressurized module arrived at KSC on June 4. It is Japan's primary contribution to the Station.

  17. KENNEDY SPACE CENTER, FLA. - International Space Station elements being processed for launch on upcoming Space Shuttle flights line the walls of the high bay in the Space Station Processing Facility. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station.

    NASA Image and Video Library

    2003-06-19

    KENNEDY SPACE CENTER, FLA. - International Space Station elements being processed for launch on upcoming Space Shuttle flights line the walls of the high bay in the Space Station Processing Facility. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The pressurized module of the Japanese Experiment Module (JEM), named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station.

  18. KENNEDY SPACE CENTER, FLA. - International Space Station elements being processed for launch on upcoming Space Shuttle flights, including the U.S. Node 2 and the Japanese Experiment Module (JEM) pressurized module, line the walls of the high bay in the Space Station Processing Facility. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The JEM pressurized module, named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station.

    NASA Image and Video Library

    2003-06-19

    KENNEDY SPACE CENTER, FLA. - International Space Station elements being processed for launch on upcoming Space Shuttle flights, including the U.S. Node 2 and the Japanese Experiment Module (JEM) pressurized module, line the walls of the high bay in the Space Station Processing Facility. NASA's Node 2, built by the European Space Agency (ESA) in Italy, arrived at KSC on June 1. It will be the next pressurized module installed on the Station. The JEM pressurized module, named "Kibo" (Hope), arrived at KSC on June 4. It is Japan's primary contribution to the Station.

  19. [European general practice research agenda].

    PubMed

    Mäntyselkä, Pekka; Koskela, Tuomas

    2014-01-01

    The EGPRN (European General Practice Research Network) research agenda is a review compiling the strengths and areas of development of European general practice, based on a systematic literature survey and its versatile analysis. The research agenda is a framework paper sharpening the definition and functions of general practice as well as its significance for researchers and decisionmakers. The agenda is useful in structuring the research, evaluation of research needs, strengthening of infrastructure and strategic planning of new research.

  20. European MEDIA Programme: the role of 'language' and 'visual images' in the processes of constructing European culture and identity.

    PubMed

    Bozić-Vrbancić, Senka; Vrbancić, Mario; Orlić, Olga

    2008-12-01

    Questions of diversity and multiculturalism are at the heart of many discussions on European supranational identity within contemporary anthropology, sociology, cultural studies, linguistics and so on. Since we are living in a period marked by the economic and political changes which emerged after European unification, a call for a new analysis of heterogeneity, cultural difference and issues of belonging is not surprising. This call has been fuelled by the European Union's concern with "culture" as one of the main driving forces for constructing "European identity". While the official European policy describes European culture as common to all Europeans, Europe is also-seen as representing "unity in diversity". By analysing contemporary European MEDIA policies and programs this article attempts to contribute to a small but growing body of work that explores what role "language" and "visual images" play in the process of constructing European culture and supranational European identity. More specifically, the article explores the complex articulation of language and culture in order to analyse supranational imaginary of European identity as it is expressed through the simple slogan "Europe: unity in diversity". We initially grounded our interest in the politics of identity within the European Union within theoretical frameworks of "power and knowledge" and "identity and subjectivity". We consider contemporary debates in social sciences and humanities over the concepts of language", "culture" and "identity" as inseparable from each other (Ahmed 2000; Brah 1996, 2000; Butler 1993, Derrida 1981; Gilroy 2004; Laclau 1990). Cultural and postcolonial studies theorists (e.g. Brah 1996; Bhabha 1994; Hall 1992, 1996, among others) argue that concepts of "culture" and "identity" signify a historically variable nexus of social meanings. That is to say, "culture" and "identity" are discursive articulations. According to this view, "culture" and "identity" are not separate

  1. Investing in European market real property through reits

    NASA Astrophysics Data System (ADS)

    Adamuscin, A.

    2010-03-01

    For institutional and private investors, investing in real estate represents an attractive form of the consignment of their money. Real estate provides a regular source of income in the form of the rent from or interest on the credit provided. At the same time, real estate is a good investment instrument, because it provides diversified contributions and security against inflation for investors. In their efforts to diversify risk, investors are expressing growing interest in investing in the whole European Union. The success of Real Estate Investment Trusts (REITs) in the U.S. also opened the door for investing in this market for small investors, which is the reason for the development of this type of investment company in the European arena. One problem concerning the development of European real estate investment funds is the unsolved issue of the harmonization of the legislation and regulatory safety measures, which would enable the creation of a common market for new investment products in Europe.

  2. What Works Clearinghouse Quick Review of the Article "Recursive Processes in Self-Affirmation: Intervening to Close the Minority Achievement Gap"

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2010

    2010-01-01

    This study examined whether having African-American middle school students write essays affirming their personal values improved their academic performance. The study analyzed data on about 175 African-American and 190 European-American students (the study's term for white students who are non-Latino and non-Asian) at a suburban middle school who…

  3. Bed Bug Clearinghouse by Audience

    EPA Pesticide Factsheets

    This information is intended to help states, communities, and consumers prevent and control bed bug infestations. Find materials for emergency and health facilities, hotels, housing authorities, landlords, schools, pest management professionals, and more.

  4. Bed Bug Clearinghouse by Topic

    EPA Pesticide Factsheets

    This information is intended to help states, communities, and consumers prevent and control bed bug infestations. Topics include bed bug biology and behavior, detection and monitoring, non-chemical techniques such as heat treatment, and pesticides.

  5. Patenting and licensing in genetic testing: recommendations of the European Society of Human Genetics.

    PubMed

    Aymé, S; Matthijs, Gert; Soini, S

    2008-05-01

    Patents for inventions can be beneficial for society, if they drive innovation and promote progress. In most areas, the patenting system works satisfactorily. However, it must be recognized that in some instances it can also be problematic; this is the case in the field of genetics, and particularly in the area of genetic testing. As patents should serve their original purpose (promoting innovation through a fair reward system for the inventors), the European Society of Human Genetics (ESHG) suggests ways to improve the mechanisms that already form part of the patents system as a whole. In brief, the ESHG recommends limiting the breadth of the claims in genetic patents and, more practically, to reduce the number of patents by limiting the patentable subject matter, thereby improving the quality of the patents that will eventually be granted. There is also a suggestion to redefine the concept of utility in patent law, by taking account of downstream clinical experience. The ESHG sees no harm in the patenting of novel technical tools for genetic testing (eg PCR or chip technologies), as they can promote investment and still allow for invention around them. Many disputes between supporters of the patenting system and the public revolve around ethical issues. The European Patent Office should consider the benefit of having an ethics committee to consider issues of major interest, such as patents applied to genes. The problem of licensing should also be addressed. Practically, this means supporting the Organisation for Economic Co-operation and Development guidelines, which prescribe that licences should be non-exclusive and easily obtainable, both in practical and in financial terms. To promote this, the practical exploration of alternative models for licensing, like patent pools and clearinghouses, is a prerequisite. To better track developments in this field, the establishment of a voluntary reporting system, whereby geneticists could report on any issues related to

  6. Argentine Population Genetic Structure: Large Variance in Amerindian Contribution

    PubMed Central

    Seldin, Michael F.; Tian, Chao; Shigeta, Russell; Scherbarth, Hugo R.; Silva, Gabriel; Belmont, John W.; Kittles, Rick; Gamron, Susana; Allevi, Alberto; Palatnik, Simon A.; Alvarellos, Alejandro; Paira, Sergio; Caprarulo, Cesar; Guillerón, Carolina; Catoggio, Luis J.; Prigione, Cristina; Berbotto, Guillermo A.; García, Mercedes A.; Perandones, Carlos E.; Pons-Estel, Bernardo A.; Alarcon-Riquelme, Marta E.

    2011-01-01

    Argentine population genetic structure was examined using a set of 78 ancestry informative markers (AIMs) to assess the contributions of European, Amerindian, and African ancestry in 94 individuals members of this population. Using the Bayesian clustering algorithm STRUCTURE, the mean European contribution was 78%, the Amerindian contribution was 19.4%, and the African contribution was 2.5%. Similar results were found using weighted least mean square method: European, 80.2%; Amerindian, 18.1%; and African, 1.7%. Consistent with previous studies the current results showed very few individuals (four of 94) with greater than 10% African admixture. Notably, when individual admixture was examined, the Amerindian and European admixture showed a very large variance and individual Amerindian contribution ranged from 1.5 to 84.5% in the 94 individual Argentine subjects. These results indicate that admixture must be considered when clinical epidemiology or case control genetic analyses are studied in this population. Moreover, the current study provides a set of informative SNPs that can be used to ascertain or control for this potentially hidden stratification. In addition, the large variance in admixture proportions in individual Argentine subjects shown by this study suggests that this population is appropriate for future admixture mapping studies. PMID:17177183

  7. Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18.

    PubMed

    Melidou, Angeliki; Broberg, Eeva

    2017-09-05

    During the European 2016/17 influenza season, A(H3N2) viruses have predominated and the majority clustered in genetic subclade 3C.2a1. Genetic analyses showed that circulating viruses have undergone considerable genetic diversification of the haemagglutinin gene from the current vaccine virus A/Hong Kong/4801/2014 (clade 3C.2a), but the antigenic data that is limited by the challenges with the antigenic characterisation of currently circulating A(H3N2) viruses, showed no clear evidence of antigenic change. The recommended A(H3N2) vaccine component for the northern hemisphere 2017/18 influenza season remained unchanged. However, early and mid-season vaccine effectiveness (VE) estimates were suggestive of reduced VE against A(H3N2) viruses. Copyright © 2017. Published by Elsevier Ltd.

  8. Developing a European Drought Observatory for Monitoring, Assessing and Forecasting Droughts across the European Continent

    NASA Astrophysics Data System (ADS)

    Vogt, J.; Barbosa, P.; Hofer, B.; Magni, D.; Jager, A. D.; Singleton, A.; Horion, S.; Sepulcre, G.; Micale, F.; Sokolova, E.; Calcagni, L.; Marioni, M.; Antofie, T. E.

    2011-12-01

    Europe, visualizing the temporal evolution over several years. Current research work is focusing on validating the available products, extending the linkage of EDO to additional national and regional drought information systems and testing medium to long-range probabilistic drought forecasting products. Probabilistic forecasts are attractive in that they provide an estimate of the range of uncertainty in a particular forecast. Longer-term goals include the development of long-range drought forecasting products, the monitoring of drought impact and the integration of EDO in a global drought monitoring system. The talk will provide an overview on the development and state of EDO, the different products, and the mechanisms and difficulties to include the different stakeholders (i.e. European, national river basin, and local authorities) in the development of the system. Finally, potential contributions to the development of a global drought early warning system will be discussed.

  9. European Spallation Source and Neutron Science

    NASA Astrophysics Data System (ADS)

    Yeck, James

    2014-03-01

    International collaborations in large-scale scientific projects can link Sciences and Society. Following this goal, the European Spallation Source (ESS) is a multi-disciplinary research centre under design and construction in Lund, Sweden. This new facility is funded by a collaboration of 17 European countries. Scandinavia is providing 50 percent of the construction cost whilst the other member states are providing financial support mainly via in-kind contribution from institutes, laboratories or industries of the given countries. Scientists and engineers from 35 different countries are members of the workforce in Lund who participate in its design and construction. The ESS will enable new opportunities for researchers in fields of life sciences, energy, environmental technology, cultural heritage and fundamental physics by producing very high flux neutrons to study condensed matter physics, chemistry, biology, nuclear physics and materials science. The ESS will be up to 30 times brighter than today's leading facilities and neutron sources. A tungsten target and a 5 MW long pulse proton accelerator, composed mainly of superconducting Radio-Frequency components, are used to achieve these goals.

  10. European Association of Echocardiography: Research Grant Programme.

    PubMed

    Gargani, Luna; Muraru, Denisa; Badano, Luigi P; Lancellotti, Patrizio; Sicari, Rosa

    2012-01-01

    The European Society of Cardiology (ESC) offers a variety of grants/fellowships to help young professionals in the field of cardiological training or research activities throughout Europe. The number of grants has significantly increased in recent years with contributions from the Associations, Working Groups and Councils of the ESC. The European Association of Echocardiography (EAE) is a registered branch of the ESC and actively takes part in this initiative. One of the aims of EAE is to promote excellence in research in cardiovascular ultrasound and other imaging modalities in Europe. Therefore, since 2008, the EAE offers a Research Grant Programme to help young doctors to obtain research experience in a high standard academic centre (or similar institution oriented to clinical or pre-clinical research) in an ESC member country other than their own. This programme can be considered as a valorization of the geographical mobility as well as cultural exchanges and professional practice in the field of cardiovascular imaging. The programme has been very successful so far, therefore in 2012 the EAE has increased its offer to two grants of 25,000 euros per annum each.

  11. European near-Earth object radar

    NASA Astrophysics Data System (ADS)

    Zaitsev, Alexander L.

    2002-11-01

    Radar astronomy paradox (RAP): practically everybody agree with essential contributions of active radar observations to Solar System and especially to near-Earth object (NEO) explorations, but despite everything prefer to develop new and new passive telescopes and disposable space missions, only, and nobody want to build at least one dedicated multipurpose radar telescope (neither Arecibo nor Goldstone and Evpatoria radars were created as dedicated radar astronomy instruments). Also, as of June 2002, among of 188 radar detected asteroids and comets there are only 3 NEOs, which were investigated in Europe, with single European radar facility, sited in Evpatoria. The main reason of such deep gap is a low sensitivity of Evpatoria radar, which is in 10 and 300 times less powerful than Goldstone and Arecibo. Therefore, I guess the first dedicated European NEO Radar (ENEOR) is earnestly needful now. From time to time we discuss this problem, but it is not solve for the present moment, perhaps because of above formulated RAP. Origin and concept of the ENEOR, as well as the ENEOR project, based on the being under construction 64-m Sardinia Radio Telescope, will be presented below.

  12. Perspectives for food research and European collaboration in the European Research Area and the new Framework Programme.

    PubMed

    Breslin, L

    2001-08-01

    Since 1987, successive framework programmes have contributed to strengthen European food research through the establishment of networks between research institutions, universities and companies from various European countries. In the FAIR programme (1994-1998), 118 research projects comprising nearly 1,000 participants from the European Union and Associated States have been supported in the food area with a European funding of about [symbol: see text] 108 million. Within the Quality of Life and Management of Living Resources programme (1998-2002), food research is mostly supported within the key action 'food, nutrition and health' with a budget of [symbol: see text] 290 million. After the first four deadlines, 735 eligible research proposals have already been received. Further to their evaluation by a panel of independent experts, 108 proposals have been funded or selected for funding representing a total contribution of about [symbol: see text] 168 million. Among those, several clusters of projects are now running on important topics such as probiotics, coeliac diseases, mycotoxins, GMO, safety and food for the elderly. In addition, technology stimulation measures are largely benefiting SMEs to foster their innovation potential. In January 2000, the European Commission adopted a Communication entitled "Towards the European Research Area (ERA)" with the objective to contribute to developing better framework conditions for research in Europe. On 21 February 2001, the Commission adopted proposals to be submitted to the European Parliament and Council for the next framework programme for research and innovation (2002-2006). The new framework programme that is becoming one of the financial instruments of the ERA aims at catalysing the integration of European research by: strengthening of links between the Community research effort and national and regional research policies; concentrating on a limited number of priority fields or research to which activities at the

  13. European guidance: a project of the European Psychiatric Association.

    PubMed

    Gaebel, W; Möller, H-J

    2012-02-01

    Evidence based medicine is a cornerstone of modern medicine including psychiatry. Treatment practice guidelines are nowadays available for guiding mental health care mainly with a focus on specific disorders. Many important clinical situations or problems beyond treatment, however, are lacking proper guidance. It is in this scope that a European Psychiatry Association (EPA) has developed its own program, the European Guidance Project. The present special issue presents six topics out of these series of guidance documents. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  14. [Contribution of the US Army Nurse Corps to the First World War].

    PubMed

    Vane, Elizabeth A P; Marble, Sanders

    2014-06-01

    A number of American nurses, on an individual basis, gave their assistance to European countries as soon as war was declared, in 1914. In 1917, when the United States entered the war, nurses from the American army arrived on the European continent before the troops. They made a major contribution to the conflict, as testified by the numerous medals they were awarded.

  15. Human vaccine research in the European Union.

    PubMed

    Olesen, Ole F; Lonnroth, Anna; Mulligan, Bernard

    2009-01-29

    The use of vaccines is saving millions of lives every year across the globe, but a number of important diseases such as HIV/AIDS, malaria, TB and hepatitis C continue to frustrate attempts to produce effective vaccines against them. Confronting these challenges will require new approaches and increased research efforts by the scientific community. The Sixth Framework Programme (FP6; 2002-2006) of the European Commission (EC) has been an important catalyst in this direction by allocating a financial contribution of more than EUR 210 million to a wide variety of vaccine research activities, ranging from basic vaccinology, translational research to clinical application of vaccines. Taken together, around 581 research groups from 52 countries are participating in the vaccine activities of FP6. This impressive number signals a new spirit of collaborative research, which will facilitate the exploitation of the immense possibilities in modern vaccinology.

  16. European courts and old people.

    PubMed

    Mulley, Graham P

    2013-09-01

    There are two major European Courts, the European Court of Justice (ECJ) and the European Court of Human Rights (ECHR). The ECJ deals with legal matters, mainly involving the interpretation of EU law and ensuring that the law is applied evenly across all 27 EU member states. The ECHR aims to make certain that civil and political rights of citizens in the 46 member states of the Council of Europe are observed. Most cases involving older citizens are about social policy (such as pension arrangements, equality, age discrimination and mandatory retirement). There have been few cases dealing with patients' rights, long-term care or housing. Referrals of selected cases involving old people should be considered if their rights are not being protected. In this Commentary, there is an account of how these Courts have evolved, together with guidance on whom to refer, to which Court, and when and how referrals should be made.

  17. European core curriculum in neurorehabilitation

    PubMed Central

    Sandrini, Giorgio; Binder, Heinrich; Hömberg, Volker; Saltuari, Leopold; Tarkka, Ina; Smania, Nicola; Corradini, Claudio; Giustini, Alessandro; Kätterer, Christian; Picari, Ledina; Diserens, Karin; Koenig, Eberhard; Geurts, Alexander; Anghelescu, Aurelian; Opara, Józef; Tonin, Paolo; Kwakkel, Gert; Golyk, Volodymyr; Onose, Gelu; Pérennou, Dominique; Picelli, Alessandro

    2017-01-01

    Summary To date, medical education lacks Europe-wide standards on neurorehabilitation. To address this, the European Federation of NeuroRehabilitation Societies (EFNR) here proposes a postgraduate neurorehabilitation training scheme. In particular, the European medical core curriculum in neurorehabilitation should include a two-year residency in a neurorehabilitation setting where trainees can gain practical experience. Furthermore, it should comprise six modules of classroom training organized as weekend seminars or summer/winter schools. In conclusion, after defining the European medical core curriculum in neurorehabilitation, the next activities of the EFNR will be to try and reach the largest possible consensus on its content among all national societies across Europe in order to further validate it and try to extend it to the other, non-medical, professionals on the neurorehabilitation team in line with their core curricula defined by each professional association. PMID:28676138

  18. European Environmental Test Facility Inventory

    NASA Astrophysics Data System (ADS)

    Popovitch, A.

    2004-08-01

    For providing the European industry with a tool enabling to identify and locate suitable test facilities, the ESA will establish and maintain a Web-based European inventory of environmental test facilities. The European Space Agency is operating a Test Centre at ESTEC Noordwijk. It is the unique place in Europe, which is geared to verify very large spacecraft. Environmental testing of systems, subsystems and components can be performed at many places all over Europe. Therefore, the inventory aims at identifying all companies/organizations active in environmental testing and inventorying their facilities as well as their main technical features and capabilities. A questionnaire will be submitted to all companies and organizations active in environmental testing in Europe and willing to appear in this inventory.

  19. European Union a New Babylon?

    NASA Astrophysics Data System (ADS)

    Mesch, F.

    2010-07-01

    The growing European Union faces growing problems in personal communication. These problems cannot be overcome only by more language courses in school. As important is a better mutual knowledge of the culture of other countries, a knowledge that can be gained only by a personal, professional stay in foreign countries. On university level, such stays are best organized by networks connecting European universities. In the broad field of measurement, this IMEKO symposium might offer a unique forum to thoroughly discuss structure and realization of such a network with all interested colleagues.

  20. Interactions between European Citizenship and Language Learning among Adolescent Europeans

    ERIC Educational Resources Information Center

    Hennebry, Mairin

    2011-01-01

    Recent enlargement of the European Union (EU) has created debate as to the suitability of current structures and policies for effectively engaging citizens and developing social cohesion. Education and specifically modern foreign language (MFL) teaching are argued by the literature to play a key role in equipping young people to interact and…

  1. Diagrams of Europeanization: European Education Governance in the Digital Age

    ERIC Educational Resources Information Center

    Decuypere, Mathias

    2016-01-01

    European education governance is increasingly affected by and effectuated through digital means. This article presents an analysis of the way in which Europe is increasingly deploying digital technologies, and more specifically websites, in order to shape and communicate its education policies. Drawing on the notion of the diagram as the…

  2. Interactions between European Citizenship and Language Learning among Adolescent Europeans

    ERIC Educational Resources Information Center

    Hennebry, Mairin

    2011-01-01

    Recent enlargement of the European Union (EU) has created debate as to the suitability of current structures and policies for effectively engaging citizens and developing social cohesion. Education and specifically modern foreign language (MFL) teaching are argued by the literature to play a key role in equipping young people to interact and…

  3. Diagrams of Europeanization: European Education Governance in the Digital Age

    ERIC Educational Resources Information Center

    Decuypere, Mathias

    2016-01-01

    European education governance is increasingly affected by and effectuated through digital means. This article presents an analysis of the way in which Europe is increasingly deploying digital technologies, and more specifically websites, in order to shape and communicate its education policies. Drawing on the notion of the diagram as the…

  4. European opportunities for fuel cell commercialisation

    NASA Astrophysics Data System (ADS)

    Gibbs, C. E.; Steel, M. C. F.

    1992-01-01

    The European electricity market is changing. This paper will look at the background to power generation in Europe and highlight the recent factors which have entered the market to promote change. The 1990s seem to offer great possibilities for fuel cell commercialisation. Awareness of environmental problems has never been greater and there is growing belief that fuel cell technology can contribute to solving some of these problems. Issues which have caused the power industry in Europe to re-think its methods of generation include: concern over increasing carbon dioxide emissions and their contribution to the greenhouse effect; increasing SO x and NO x emissions and the damage cause by acid rain; the possibility of adverse effects on health caused by high voltage transmission lines; environmental restrictions to the expansion of hydroelectric schemes; public disenchantment with nuclear power following the Chernobyl accident; avoidance of dependence on imported oil following the Gulf crisis and a desire for fuel flexibility. All these factors are hastening the search for clean, efficient, modular power generators which can be easily sited close to the electricity consumer and operated using a variety of fuels. It is not only the power industry which is changing. A tightening of the legislation concerning emissions from cars is encouraging European auto companies to develop electric vehicles, some of which may be powered by fuel cells. Political changes, such as the opening up of Eastern Europe will also expand the market for low-emission, efficient power plants as attempts are made to develop and clean up that region. Many Europeans organisations are re-awakening their interest, or strengthening their activities, in the area of fuel cells because of the increasing opportunities offered by the European market. While some companies have chosen to buy, test and demonstrate Japanese or American fuel cell stacks with the aim of gaining operational experience and

  5. The exodus of German dermatologists and their contributions to their adopted countries.

    PubMed

    Scholz, Albrecht; Burgdorf, Walter

    2005-01-01

    This study reviews the establishment of dermatology in Germany, the exodus of German dermatologists during the Third Reich, and their contribution to dermatology in the United States and European countries.

  6. Integration through Europeanization: Ukraine’s Policy Towards the European Union

    DTIC Science & Technology

    2012-06-08

    Europeanization . The Orange Revolution of late 2004, and the implementation of the European Neighbourhood Policy , significantly improved Ukraine’s European ...of the European Neighbourhood Policy , significantly improved Ukraine’s European prospects. This thesis examines Ukraine’s efforts to undertake the... Neighbourhood Policy and Ukraine is one of six post-Soviet states invited to cooperate with the European Union within the multilateral

  7. A Grand Vision for European Astronomy

    NASA Astrophysics Data System (ADS)

    2007-09-01

    Today, and for the first time, astronomers share their global Science Vision for European Astronomy in the next two decades. This two-year long effort by the ASTRONET network of funding agencies, sponsored by the European Commission and coordinated by INSU-CNRS, underscores Europe's ascension to world leadership in astronomy and its will to maintain that position. It will be followed in just over a year by a prioritised roadmap for the observational facilities needed to implement the Vision. Implementation of these plans will ensure that Europe fully contributes to Mankind's ever deeper understanding of the wonders of our Universe. astronet logo "This is a great opportunity to help create a vibrant long-term future for astronomy and science" says Tim de Zeeuw (Leiden Observatory, The Netherlands) who led this community-wide effort. The ASTRONET Science Vision provides a comprehensive overview of the most important scientific questions that European astronomy should address in the next twenty years. The four key questions are the extremes of the Universe, from the nature of the dark matter and dark energy that comprise over 95% of the Universe to the physics of extreme objects such as black holes, neutron stars, and gamma-ray bursts; the formation of galaxies from the first seeds to our Milky Way; the formation of stars and planets and the origin of life; and the crucial question of how do we (and our Solar System) fit in the global picture. These themes reach well beyond the realm of traditional astronomy into the frontiers of physics and biology. The Vision identifies the major new facilities that will be needed to achieve these goals, but also stresses the need for parallel developments in theory and numerical simulations, high-performance computing resources, efficient astronomical data archiving and the European Virtual Observatory, as well as in laboratory astrophysics. "This report is a key input for the even more challenging task of developing a prioritised

  8. Samuel Dyer and His Contributions to Chinese Typography.

    ERIC Educational Resources Information Center

    Ismail, Ibrahim bin

    1984-01-01

    This history of a London Missionary Society member's contributions to typography development in China highlights selection of 3,000 Chinese characters needed for purpose of printing Christian books, production of temporary font from wooden blocks, and use of European methods of punches and matrices to produce permanent metal font. (Twenty-seven…

  9. Does the EUA Institutional Evaluation Programme Contribute to Quality Improvement?

    ERIC Educational Resources Information Center

    Tavares, Diana Amado; Rosa, Maria Joao; Amaral, Alberto

    2010-01-01

    Purpose: This paper aims to reflect on the relevance of the Institutional Evaluation Programme (IEP) of the European University Association (EUA) to universities' quality improvement. It aims to analyse IEP follow-up reports to determine whether the programme contributes to the development of a quality improvement culture.…

  10. Does the EUA Institutional Evaluation Programme Contribute to Quality Improvement?

    ERIC Educational Resources Information Center

    Tavares, Diana Amado; Rosa, Maria Joao; Amaral, Alberto

    2010-01-01

    Purpose: This paper aims to reflect on the relevance of the Institutional Evaluation Programme (IEP) of the European University Association (EUA) to universities' quality improvement. It aims to analyse IEP follow-up reports to determine whether the programme contributes to the development of a quality improvement culture.…

  11. Samuel Dyer and His Contributions to Chinese Typography.

    ERIC Educational Resources Information Center

    Ismail, Ibrahim bin

    1984-01-01

    This history of a London Missionary Society member's contributions to typography development in China highlights selection of 3,000 Chinese characters needed for purpose of printing Christian books, production of temporary font from wooden blocks, and use of European methods of punches and matrices to produce permanent metal font. (Twenty-seven…

  12. Modelling the dispersion of particle numbers in five European cities

    NASA Astrophysics Data System (ADS)

    Kukkonen, J.; Karl, M.; Keuken, M. P.; Denier van der Gon, H. A. C.; Denby, B. R.; Singh, V.; Douros, J.; Manders, A.; Samaras, Z.; Moussiopoulos, N.; Jonkers, S.; Aarnio, M.; Karppinen, A.; Kangas, L.; Lützenkirchen, S.; Petäjä, T.; Vouitsis, I.; Sokhi, R. S.

    2016-02-01

    We present an overview of the modelling of particle number concentrations (PNCs) in five major European cities, namely Helsinki, Oslo, London, Rotterdam, and Athens, in 2008. Novel emission inventories of particle numbers have been compiled both on urban and European scales. We used atmospheric dispersion modelling for PNCs in the five target cities and on a European scale, and evaluated the predicted results against available measured concentrations. In all the target cities, the concentrations of particle numbers (PNs) were mostly influenced by the emissions originating from local vehicular traffic. The influence of shipping and harbours was also significant for Helsinki, Oslo, Rotterdam, and Athens, but not for London. The influence of the aviation emissions in Athens was also notable. The regional background concentrations were clearly lower than the contributions originating from urban sources in Helsinki, Oslo, and Athens. The regional background was also lower than urban contributions in traffic environments in London, but higher or approximately equal to urban contributions in Rotterdam. It was numerically evaluated that the influence of coagulation and dry deposition on the predicted PNCs was substantial for the urban background in Oslo. The predicted and measured annual average PNCs in four cities agreed within approximately ≤ 26 % (measured as fractional biases), except for one traffic station in London. This study indicates that it is feasible to model PNCs in major cities within a reasonable accuracy, although major challenges remain in the evaluation of both the emissions and atmospheric transformation of PNCs.

  13. A Space for the European Higher Education Area: The Guidance from the EU Court of Justice to Member States

    ERIC Educational Resources Information Center

    Kwikkers, Peter; van Wageningen, Anne

    2012-01-01

    The European Court of Justice has developed a body of jurisprudence that regulates issues such as access, capacity, quality, student allowances and labour market needs, and that should be considered at least an even more important contribution to the European Higher Education Area (EHEA) than the Bologna process. The Bressol and Chaverot cases…

  14. "Governmentality" in the Origins of European Female PE and Sport: The Spanish Case Study (1883-1936)

    ERIC Educational Resources Information Center

    Garcia, Raul Sanchez; Herraiz, Antonio Rivero

    2013-01-01

    The purpose of the paper is twofold: (1) to contribute to the analysis of the origins of modern European female PE and sports from a power perspective, inspired by Foucault's work; and (2) to present a detailed analysis of female PE and sport in Spain (1883-1936) as a specific European case study. It is argued that these physical activities could…

  15. E-Learning in European Higher Education Institutions: Results of a Mapping Survey Conducted in October-December 2013

    ERIC Educational Resources Information Center

    Gaebel, Michael; Kupriyanova, Veronika; Morais, Rita; Colucci, Elizabeth

    2014-01-01

    The present study on e-learning intends to contribute to closing a data gap and to stimulate the discussion on the further development of national and European policies on the issue and to support its systematic institutional take-up. It draws upon a survey conducted by the European University Association between October and December 2013. 249…

  16. E-Learning in European Higher Education Institutions: Results of a Mapping Survey Conducted in October-December 2013

    ERIC Educational Resources Information Center

    Gaebel, Michael; Kupriyanova, Veronika; Morais, Rita; Colucci, Elizabeth

    2014-01-01

    The present study on e-learning intends to contribute to closing a data gap and to stimulate the discussion on the further development of national and European policies on the issue and to support its systematic institutional take-up. It draws upon a survey conducted by the European University Association between October and December 2013. 249…

  17. European tests on materials outgassing

    NASA Technical Reports Server (NTRS)

    Zwaal, A.

    1977-01-01

    With a view to international coordination of spacecraft materials, a number of European firms and institutes performed outgassing tests on identical materials at 125 C in high vacuum. The outgassing data obtained with the different types of equipment is presented and both the results and the critical parameters are discussed.

  18. New Superpower, The European Union

    DTIC Science & Technology

    1994-05-01

    196 from Japan and 210 from the EC; in the Super Fifty non-American 27 are from the common market. It is clear that the European Union will be one of...C687e). (page 31, bottom)4 Mastrivh treaty, articulo 6Mastrich treaty, articulo 6Janes 1994, pag 31. 8ii JRATOM and Nuclear Safeguards. Darryl A

  19. European Curricula, Xenophobia and Warfare.

    ERIC Educational Resources Information Center

    Coulby, David

    1997-01-01

    Examines school and university curricula in Europe and the extent of their influence on xenophobia. Considers the pluralistic nature of the European population. Discusses the role of curriculum selection and language policy in state efforts to promote nationalism. Assesses the role of curricular systems in the actual encouragement of warfare,…

  20. Scholarships for European vet students.

    PubMed

    Egan, Jordon; Takacs, Daniella

    2017-02-25

    Every year, students from European vet schools can apply for $5000 scholarships, which aim to 'enhance the academic experience of students'. Among last year's recipients were Jordon Egan, from the Royal Veterinary College, and Daniella Takács, from the University of Veterinary Medicine in Budapest. British Veterinary Association.

  1. Mathematical Modelling in European Education

    ERIC Educational Resources Information Center

    Ferri, Rita Borromeo

    2013-01-01

    Teaching and learning of mathematical modelling has become a key competence within school curricula and educational standards in many countries of the world. The term mathematical modelling, its meaning, and how it can be implemented in mathematics lessons have been intensively discussed during several Conferences of the European Society for…

  2. Reconstructing Indo-European Syllabification

    ERIC Educational Resources Information Center

    Byrd, Andrew Miles

    2010-01-01

    The chief concern of this dissertation is to investigate a fundamental, yet unsolved problem within the phonology of Proto-Indo-European (PIE): the process of syllabification. I show that by analyzing the much more easily reconstructable word-edge clusters we may predict which types of consonant clusters can occur word-medially, provided that we…

  3. Mathematical Modelling in European Education

    ERIC Educational Resources Information Center

    Ferri, Rita Borromeo

    2013-01-01

    Teaching and learning of mathematical modelling has become a key competence within school curricula and educational standards in many countries of the world. The term mathematical modelling, its meaning, and how it can be implemented in mathematics lessons have been intensively discussed during several Conferences of the European Society for…

  4. European perspectives in thoracic surgery

    PubMed Central

    2014-01-01

    Europe, the old Continent, has been the cradle of thoracic surgery from the beginning of the last century. The structure and the activities of the European Society of Thoracic Surgeons (ESTS) activities are directed to enlighten the path, provide the tools and set the standards for a quality inspired practice in thoracic surgery. PMID:24868436

  5. Beyond "Ability": Some European Alternatives

    ERIC Educational Resources Information Center

    Wrigley, Terry

    2013-01-01

    This article draws on European approaches to differentiation that do not entail fatalistic determinism. It describes two challenging initiatives in Denmark, where democratic learning and learning for democracy are enshrined in law. Other examples come from Germany, from the Bielefeld laboratory school and a sixth form college, where planning for…

  6. Attitudes of Europeans toward Age.

    ERIC Educational Resources Information Center

    Ageing International, 1993

    1993-01-01

    Two Commission of European Communities surveys of people over age 15 and of those over 60 demonstrated a widespread belief that older people deserve public support and services and face employment discrimination. Socioeconomic factors influenced older people's sense of security and life satisfaction. Positive intergenerational attitudes appeared.…

  7. European Year of Languages, 2001.

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France). Directorate of Education, Culture and Sport, Documentation Section.

    This document is a folder full of brochures describing the activities of Council of Europe and the European Union to celebrate 2001 as a year of languages in order to celebrate the linguistic diversity of Europe and promote the many opportunities available for lifelong language learning. A number of facts and figures about the languages of Europe…

  8. OER: A European Policy Perspective

    ERIC Educational Resources Information Center

    Alquézar Sabadie, Jesús Maria; Castaño Muñoz, Jonatan; Puni, Yves; Redecker, Christine; Vuorikari, Riina

    2014-01-01

    The potential benefits of OER have led many European governments to implement policies supporting their creation and use. This chapter aims to put these OER policies in context, discussing their focus and scope and highlighting challenges and bottlenecks. On the basis of the analysis of the current state of the art, it is argued that one of main…

  9. Reconstructing Indo-European Syllabification

    ERIC Educational Resources Information Center

    Byrd, Andrew Miles

    2010-01-01

    The chief concern of this dissertation is to investigate a fundamental, yet unsolved problem within the phonology of Proto-Indo-European (PIE): the process of syllabification. I show that by analyzing the much more easily reconstructable word-edge clusters we may predict which types of consonant clusters can occur word-medially, provided that we…

  10. Appendix: Additional Contributions

    NASA Astrophysics Data System (ADS)

    2011-12-01

    The number of contributions to the Symposium was so high that only the review and invited talks have found place, in the form of articles, in this volume. This Appendix lists all these additional contributions (oral and posters) which are not present as articles. The abstracts of all contributions were published in a booklet produced by the Local Organizing Committee and are available at the SAO/NASA Astrophysics Data System (ADS). More information on these contributions (PowerPoint presentations and/or articles) have been made public in the Internet web site of the conference (http://cab.inta-csic.es/molecular_universe/).

  11. A time transect of exomes from a Native American population before and after European contact

    PubMed Central

    Lindo, John; Huerta-Sánchez, Emilia; Nakagome, Shigeki; Rasmussen, Morten; Petzelt, Barbara; Mitchell, Joycelynn; Cybulski, Jerome S.; Willerslev, Eske; DeGiorgio, Michael; Malhi, Ripan S.

    2016-01-01

    A major factor for the population decline of Native Americans after European contact has been attributed to infectious disease susceptibility. To investigate whether a pre-existing genetic component contributed to this phenomenon, here we analyse 50 exomes of a continuous population from the Northwest Coast of North America, dating from before and after European contact. We model the population collapse after European contact, inferring a 57% reduction in effective population size. We also identify signatures of positive selection on immune-related genes in the ancient but not the modern group, with the strongest signal deriving from the human leucocyte antigen (HLA) gene HLA-DQA1. The modern individuals show a marked frequency decrease in the same alleles, likely due to the environmental change associated with European colonization, whereby negative selection may have acted on the same gene after contact. The evident shift in selection pressures correlates to the regional European-borne epidemics of the 1800s. PMID:27845766

  12. Georgius Agricola's contributions to hydrology

    NASA Astrophysics Data System (ADS)

    Barton, Isabel F.

    2015-04-01

    Georgius Agricola's 1546 book De Ortu et Causis Subterraneorum (On the Source and Causes of What is Underground) was the first European work since antiquity to focus on hydrology and helped to shape the thought of Nicolaus Steno, Pierre Perrault, A.G. Werner, and other important figures in the history of hydrology and geology. De Ortu contains the first known expressions of numerous concepts important in modern hydrology: erosion as an active process, groundwater movement through pores and fissures, hydrofracturing, water-rock reaction, and others. The concepts of groundwater origins, movement, and nature in De Ortu were also the foundation for the theories of ore deposit formation for which Agricola is better known. In spite of their importance, most of Agricola's contributions to the study of groundwater are unrecognized today because De Ortu, alone of his major works, has never been translated out of Latin and no existing vernacular summary of it is longer than two pages. This article presents the first detailed description of Agricola's work on hydrology and discusses the derivation and impact of his ideas.

  13. Possible Russian Contribution to the ERNP

    NASA Astrophysics Data System (ADS)

    Denisov, Vladimir; Kent, Peter

    1998-09-01

    This paper, and the following five papers, were presented during the NAV 97 Conference held at Church House, Westminster, London on 11th and 12th November 1997. A full listing of the Conference, and how to obtain a copy of the proceedings, is shown on Page 279.The Government of the Russian Federation has made available, subject to certain conditions, the GLONASS satellite radionavigation system for civil use. Useof the system is free and there is no intention to introduce coding or to cause any deterioration to the accuracy of the signals. Discussions are currently taking place between the European Commission and the Russian Federation on cooperation concerning the implementation of a navigation satellite system for civil purposes. Discussions are also taking place between interested European Governments and the Russian Federation into the possibility of developing joint Chayka/Loran-C chains wherever this is feasible, and in particular, to cover the Barents Sea, the Baltic Sea and the Black Sea. The development of a concept on integration of radionavigation systems would probably be a significant contribution to the European Radionavigation Plan.

  14. Towards drought risk mapping on a pan-European scale

    NASA Astrophysics Data System (ADS)

    Blauhut, Veit; Gudmundsson, Lukas; Stahl, Kerstin; Seneviratne, Sonia

    2014-05-01

    Drought is a very complex and multifarious natural hazard, which causes a variety of direct and indirect environmental and socio-economic impacts. For the last 30 years, droughts in Europe caused over 100 billion Euros of losses from impacts in various sectors e.g. agriculture, water quality or energy production. Despite the apparent importance of this hazard observed pan-European drought impacts have not yet been quantitatively related to the most important climatological drivers. Fundamentally, a common approach to describe drought risk on a pan-European scale is still missing. This contribution presents an approach for linking climatological drought indices with observed drought impacts at the European scale. Standardized precipitation index (SPI) and standardized precipitation and evapotranspiration index (SPEI) for different time scales were calculated based on E-OBS data and are used to describe the drought hazard. Data from the European Drought Impact Inventory (EDII) compiled by the EU FP7 Drought R&SPI (Fostering European Drought Research and Science-Policy Interfacing) project are used as a proxy for multi-sectorial (impact categories) vulnerability following the assumption that a reported impact reflects a region's vulnerability to the hazard. Drought risk is then modelled statistically by applying logistic regression to estimate the probability of impact report occurrence as a function of SPI and SPEI. This approach finally allows to map the probability of drought impact occurrence on a year by year basis. The emerging patterns compare well to many known European drought events. Such maps may become an essential component of Drought Risk Management to foster resilience for this hazard at the large scale.

  15. European Centre for Disease Prevention and Control.

    PubMed

    Evans, Roger

    2014-11-04

    The European Centre for Disease Prevention and Control was set up in 2005 to strengthen Europe's defences against infectious diseases. The centre is an independent agency of the European Union and is based in Stockholm, Sweden.

  16. New head picked for European Spallation Source

    NASA Astrophysics Data System (ADS)

    Banks, Michael

    2016-06-01

    The UK physicist John Womersley is to become the next director-general of the €1.8bn European Spallation Source (ESS), which is currently being built in Lund, Sweden, by a 17-member consortium of European countries.

  17. European Cargo Ship Launches to Station

    NASA Image and Video Library

    The European Space Agency's third Automated Transfer Vehicle (ATV-3) launched atop an Ariane 5 rocket from the European space port in Kourou, French Guiana, at 12:34 a.m. EDT Friday, beginning a si...

  18. Meeting US and European supplier control requirements.

    PubMed

    Donawa, Maria

    2009-01-01

    Medical device manufacturers operating under European quality system requirements are sometimes surprised to learn that their supplier control procedures do not fully meet United States (US) requirements. This article discusses important differences between US and European requirements for controlling suppliers.

  19. European Security: Chances for a European Defense Entity

    DTIC Science & Technology

    1991-04-12

    terms of a (military) balance between Russia , Germany, Great Britain, France and Austria-Hungary. The balance was not stable as diplomacy...defensie tegen een nieuwe achtergrond," Nederlands instituut voor internationale betrekkingen ’Clingendael,’ November 1990, p. 6, ("The image of threat...implications for Europe as a consequence of the Gulf crisis; o How to cooperate with the East European Nations. See Jan Gerritsen, " Nederland

  20. European psychotraumatology – alongside the recent European history

    PubMed Central

    Lueger-Schuster, Brigitte

    2013-01-01

    This article outlines a personal reflection of experiences within the field of traumatic stress, especially in relation to specific events, which affected the author's professional life. Conclusions for further challenges for European Society for Traumatic Stress Studies (ESTSS) are delineated. ESTSS's role in the global network of traumatic stress societies is discussed. This is a personal view of Brigitte Lueger-Schuster, president of ESTSS on behalf of the 20th birthday of ESTSS. PMID:23755321

  1. Twenty-First Century Europe: Emergence of Baltic States into European Alliances

    DTIC Science & Technology

    2003-04-07

    sources of power supply. Estonia is the only country in the world where oil shale is the primary source of energy, supplying over 75 percent of its total...Unclassified The contributions of Estonia , Latvia, and Lithuania ("the Baltic States") to the North Atlantic Treaty Organization (NATO), the European...23 vi TWENTY-FIRST CENTURY EUROPE: EMERGENCE OF THE BALTIC STATES INTO EUROPEAN ALLIANCES BACKGROUND Estonia , Latvia, and Lithuania are often

  2. The Independent European Force: Costs of Independence

    DTIC Science & Technology

    1993-01-01

    Western European Union (WEU). Advocates of this approach see the European effort as complementary to NATO and oriented toward coalitional activities...Board Spot) Seaport ofdebarkation USAF United States Air Force WEU Western European Union 1.Introduction Background Th amunceoMentAS I in May 1991...Europe-has sparked criticism within Europe. Speaking at a miseting of the Western European Union (WEU), French Foreign Minister Roland Dumnas argued that

  3. ETUDE - European Trade Union Distance Education.

    ERIC Educational Resources Information Center

    Creanor, Linda; Walker, Steve

    2000-01-01

    Describes transnational distance learning activities among European trade union educators carried out as part of the European Trade Union Distance Education (ETUDE) project, supported by the European Commission. Highlights include the context of international trade union distance education; tutor training course; tutors' experiences; and…

  4. Our European Neighbours. Vocational Training No. 2.

    ERIC Educational Resources Information Center

    Vocational Training, 1989

    1989-01-01

    This document addresses vocational training in European countries. The document contains the following articles: (1) "Dear Readers" (Ernst Piehl and Georges Dupont); (2) "Interview with Lord Plumb, President of the European Parliament" (Georges Dupont); "The European Community's 'Ostpolitik'" (Horst G. Krenzler);…

  5. Europeanizing Education: Governing a New Policy Space

    ERIC Educational Resources Information Center

    Lawn, Martin; Grek, Sotiria

    2012-01-01

    The study of common and diverse effects in the field of education across Europe is a growing field of inquiry and research. It is the result of many actions, networks and programmes over the last few decades and the development of common European education policies. "Europeanizing Education" describes the origins of European education…

  6. How Is European Governance Configuring the EHEA?

    ERIC Educational Resources Information Center

    Magalhães, António; Veiga, Amélia; Sousa, Sofia; Ribeiro, Filipa

    2012-01-01

    This article focuses on the interaction between the European dimension driven by the creation of the European Higher Education Area (EHEA) and the development of national reforms to fulfil that objective. On the basis of data gathered in eight countries involved in EuroHESC project TRUE (Transforming European Universities), the curricular and the…

  7. Europeanizing Education: Governing a New Policy Space

    ERIC Educational Resources Information Center

    Lawn, Martin; Grek, Sotiria

    2012-01-01

    The study of common and diverse effects in the field of education across Europe is a growing field of inquiry and research. It is the result of many actions, networks and programmes over the last few decades and the development of common European education policies. "Europeanizing Education" describes the origins of European education…

  8. European Initiatives in Postgraduate Education in Gerontology

    ERIC Educational Resources Information Center

    van Rijsselt, Rene J. T.; Parkatti, Terttu; Troisi, Joseph

    2007-01-01

    This paper describes three innovative European initiatives in postgraduate education in gerontology. The first is the European Masters Program in Gerontology (EuMaG), developed as an interdisciplinary joint program, supported and delivered by 22 European universities. Second, the Nordplus initiative to increase mobility of students and staff in…

  9. European Initiatives in Postgraduate Education in Gerontology

    ERIC Educational Resources Information Center

    van Rijsselt, Rene J. T.; Parkatti, Terttu; Troisi, Joseph

    2007-01-01

    This paper describes three innovative European initiatives in postgraduate education in gerontology. The first is the European Masters Program in Gerontology (EuMaG), developed as an interdisciplinary joint program, supported and delivered by 22 European universities. Second, the Nordplus initiative to increase mobility of students and staff in…

  10. How Is European Governance Configuring the EHEA?

    ERIC Educational Resources Information Center

    Magalhães, António; Veiga, Amélia; Sousa, Sofia; Ribeiro, Filipa

    2012-01-01

    This article focuses on the interaction between the European dimension driven by the creation of the European Higher Education Area (EHEA) and the development of national reforms to fulfil that objective. On the basis of data gathered in eight countries involved in EuroHESC project TRUE (Transforming European Universities), the curricular and the…

  11. First-Ever European Space Weather Week

    NASA Astrophysics Data System (ADS)

    Simpson, Sarah

    2004-07-01

    Europe's first Space Weather Week is scheduled to take place at the European Space Agency's European Space Research and Technology Centre (ESTEC) in Noordwijk, The Netherlands, for five days beginning 29 November. Modeled after the U.S. Space Weather Week, the European agenda will highlight not only services and applications but also the crucial activity of transitioning scientific discoveries into forecasting capabilities.

  12. IDS contribution to ITRF2008

    NASA Astrophysics Data System (ADS)

    Valette, J.; Lemoine, F.; Ferrage, P.; Altamimi, Z.; Willis, P.; Stepanek, P.; Otten, M.; Govind, R.; Kuzin, S.; Le Bail, K.; Moore, P.; Yaya, P.; Soudarin, L.

    2009-12-01

    The International DORIS Service (IDS), in operation since 2003, submitted three sets of solutions to ITRF2005 from the IGN/JPL, LEGOS/CLS, and INASAN analysis centers, but no DORIS technique combination. Since that time new analysis centers have become operational including the Geodetic Observatory Pecny (GOP), the European Space Operations Center (ESOC), Geoscience Australia (GAU), the NASA Goddard Space Flight Center (GSC), and the University of Newcastle (NCL). These analysis centers run different software, including Gypsy (IGN & INASAN), GINS (LCA), Bernese (GOP), NAPEOS (ESOC), GEODYN (Geoscience Australia and NASA GSFC) and FAUST (NCL). In order to contribute to ITRF2008, seven analysis centers processed DORIS data from TOPEX/Poseidon, SPOT2, SPOT3, SPOT4, SPOT5, and ENVISAT from 1992 to 2008, producing weekly SINEX solutions or normal equations. The weekly SINEX files from seven AC’s were processed with the CATREF software. Three iterations of an IDS weekly combined time series were completed. The IDS-1, and IDS-2 combinations were preliminary station-only solutions. In the final combination, IDS-3, both stations and the Earth Orientation Paramters (EOP’s) were adjusted. Between each of the IDS combinations, the combination strategy (station filtering, outliers, weighting, scale or geocenter contributions) was improved and the AC’s SINEX series were refined. Some series were extended in data span while others were recomputed to correct anomalies or to improve the quality of the submissions, based on feedback from the combination analyses and intercenter comparisons. For example in IDS-1, both the GAU and GSC solutions were affected by a 20 mm scale offset that was removed in IDS-2 and IDS-3 after the application of improved troposphere modelling in the GEODYN software. The analysis for IDS-1 showed a higher station position WRMS in the vicinity of the high solar flux periods (late 2001-2002). Consequently for IDS-2, several AC’s (LCA, GAU, GSC

  13. Making Citizens, Being European? European Symbolism in Slovenian Citizenship Education Textbooks

    ERIC Educational Resources Information Center

    Banjac, Marinko; Pušnik, Tomaž

    2015-01-01

    Citizenship education has been an important part of the European Union's (EU) agenda to integrate a European dimension into schools' curricula. The usage of European symbolism in citizenship education curriculum material has been an especially important (yet understudied) means not only to promote a distinct European identity and increase…

  14. Making Citizens, Being European? European Symbolism in Slovenian Citizenship Education Textbooks

    ERIC Educational Resources Information Center

    Banjac, Marinko; Pušnik, Tomaž

    2015-01-01

    Citizenship education has been an important part of the European Union's (EU) agenda to integrate a European dimension into schools' curricula. The usage of European symbolism in citizenship education curriculum material has been an especially important (yet understudied) means not only to promote a distinct European identity and increase…

  15. Traceability from a European perspective.

    PubMed

    Schwägele, F

    2005-09-01

    At pan-European level there is a need for traceability systems giving information on origin, processing, retailing and final destination of foodstuffs. Such systems shall enhance consumer confidence in food; enable the regulatory authorities to identify and to withdraw health hazardous and non-consumable foodstuffs from the market. Animal feeds are an element in this "food-to-farm" approach to public health. Such feedstuffs are preliminary elements of some foods for human consumption, and hence are an inherent element of the food chain. A harmonised pan-European food traceability protocol would greatly assist authorities in detecting fraud as well as dangerous substances. The food chain comprises a range of sequential and parallel stages bridging the full spectrum from agricultural production to the consumable foodstuffs by consumers. EU legislation on traceability and the technologies needed to implement this system for meat and meat products are the focus of this paper.

  16. Integrating the European Securities Settlement

    NASA Astrophysics Data System (ADS)

    Schaper, Torsten

    The cross-border securities settlement in Europe is still said to be highly inefficient. One main reason can be seen in technical barriers between the different domestic settlement systems. Beside efforts to implement industry-specific communication standards an integration of the different settlement systems is necessary. The CSD-link model, the hub and spokes model, and the European CSD model aim to integrate European securities settlement. They have in common that they address the problem of interlinkage of national Central Securities Depositories and differ essentially in the way of achieving integration. These models are evaluated from a macro-economic perspective considering transaction costs, risks, and the integration of the cross-border securities settlement process.

  17. Carbon accumulation in European forests

    NASA Astrophysics Data System (ADS)

    Ciais, P.; Schelhaas, M. J.; Zaehle, S.; Piao, S. L.; Cescatti, A.; Liski, J.; Luyssaert, S.; Le-Maire, G.; Schulze, E.-D.; Bouriaud, O.; Freibauer, A.; Valentini, R.; Nabuurs, G. J.

    2008-07-01

    European forests are intensively exploited for wood products, yet they also form a sink for carbon. European forest inventories, available for the past 50 years, can be combined with timber harvest statistics to assess changes in this carbon sink. Analysis of these data sets between 1950 and 2000 from the EU-15 countries excluding Luxembourg, plus Norway and Switzerland, reveals that there is a tight relationship between increases in forest biomass and forest ecosystem productivity but timber harvests grew more slowly. Encouragingly, the environmental conditions in combination with the type of silviculture that has been developed over the past 50 years can efficiently sequester carbon on timescales of decades, while maintaining forests that meet the demand for wood. However, a return to using wood as biofuel and hence shorter rotations in forestry could cancel out the benefits of carbon storage over the past five decades.

  18. Proposal for the creation of a European healthcare identifier.

    PubMed

    Quantin, Catherine; Allaert, François-André; Gouyon, Béatrice; Cohen, Olivier

    2005-01-01

    In France, the European health card was created in June 2004 to increase the quality of healthcare granted to european citizen anywhere in europe and to facilitate the reimbursement of the healthcare costs. The patient identifier included in this card is essentially based on the healthcare insurance number of the patient and does not allow any linkage with his (her) previous health care data if he (she) is affiliated to another national healthcare insurance system when working for a long duration outside France. The purpose of this paper is to present the concept of a personal identifier based on familial components which has been validated by the French authority for personal data protection in the framework of a genetic study. Results issued from the Burgundy perinatal network demonstrate the interest and the faisability of adding a maternal component to the individual component of the new-born to allow Mother/new-born healthcare data linkage after anonymization. The advantage of adding a familial component to the healthcare insurance number is debated. This proposal will permit to link the data of a patient even when residing outside his country in Europe. It will also contribute to establish european public health statistics by matching healthcare data of the patients' records with other administrative data (mortality, social information ..) after anonymisation of these data in accordance with the European directive on data protection.

  19. A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics

    PubMed Central

    Mizzi, Clint; Dalabira, Eleni; Kumuthini, Judit; Dzimiri, Nduna; Balogh, Istvan; Başak, Nazli; Böhm, Ruwen; Borg, Joseph; Borgiani, Paola; Bozina, Nada; Bruckmueller, Henrike; Burzynska, Beata; Carracedo, Angel; Cascorbi, Ingolf; Deltas, Constantinos; Dolzan, Vita; Fenech, Anthony; Grech, Godfrey; Kasiulevicius, Vytautas; Kádaši, Ľudevít; Kučinskas, Vaidutis; Khusnutdinova, Elza; Loukas, Yiannis L.; Macek, Milan; Makukh, Halyna; Mathijssen, Ron; Mitropoulos, Konstantinos; Mitropoulou, Christina; Novelli, Giuseppe; Papantoni, Ioanna; Pavlovic, Sonja; Saglio, Giuseppe; Setric, Jadranka; Stojiljkovic, Maja; Stubbs, Andrew P.; Squassina, Alessio; Torres, Maria; Turnovec, Marek; van Schaik, Ron H.; Voskarides, Konstantinos; Wakil, Salma M.; Werk, Anneke; del Zompo, Maria; Zukic, Branka; Katsila, Theodora; Lee, Ming Ta Michael; Motsinger-Rief, Alison; Mc Leod, Howard L.; van der Spek, Peter J.; Patrinos, George P.

    2016-01-01

    Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism and transport. In several European populations, particularly in countries with lower income, information related to the prevalence of pharmacogenomic biomarkers is incomplete or lacking. Here, we have implemented the microattribution approach to assess the pharmacogenomic biomarkers allelic spectrum in 18 European populations, mostly from developing European countries, by analyzing 1,931 pharmacogenomics biomarkers in 231 genes. Our data show significant inter-population pharmacogenomic biomarker allele frequency differences, particularly in 7 clinically actionable pharmacogenomic biomarkers in 7 European populations, affecting drug efficacy and/or toxicity of 51 medication treatment modalities. These data also reflect on the differences observed in the prevalence of high-risk genotypes in these populations, as far as common markers in the CYP2C9, CYP2C19, CYP3A5, VKORC1, SLCO1B1 and TPMT pharmacogenes are concerned. Also, our data demonstrate notable differences in predicted genotype-based warfarin dosing among these populations. Our findings can be exploited not only to develop guidelines for medical prioritization, but most importantly to facilitate integration of pharmacogenomics and to support pre-emptive pharmacogenomic testing. This may subsequently contribute towards significant cost-savings in the overall healthcare expenditure in the participating countries, where pharmacogenomics implementation proves to be cost-effective. PMID:27636550

  20. Emerging fungal pathogen Ophidiomyces ophiodiicola in wild European snakes

    USGS Publications Warehouse

    Franklinos, Lydia H. V.; Lorch, Jeffrey M.; Bohuski, Elizabeth A.; Rodriguez-Ramos Fernandez, Julia; Wright, Owen; Fitzpatrick, Liam; Petrovan, Silviu; Durrant, Chris; Linton, Chris; Baláž, Vojtech; Cunningham, Andrew A; Lawson, Becki

    2017-01-01

    Snake fungal disease (SFD) is an emerging disease of conservation concern in eastern North America. Ophidiomyces ophiodiicola, the causative agent of SFD, has been isolated from over 30 species of wild snakes from six families in North America. Whilst O. ophiodiicola has been isolated from captive snakes outside North America, the pathogen has not been reported from wild snakes elsewhere. We screened 33 carcasses and 303 moulted skins from wild snakes collected from 2010–2016 in Great Britain and the Czech Republic for the presence of macroscopic skin lesions and O. ophiodiicola. The fungus was detected using real-time PCR in 26 (8.6%) specimens across the period of collection. Follow up culture and histopathologic analyses confirmed that both O. ophiodiicola and SFD occur in wild European snakes. Although skin lesions were mild in most cases, in some snakes they were severe and were considered likely to have contributed to mortality. Culture characterisations demonstrated that European isolates grew more slowly than those from the United States, and phylogenetic analyses indicated that isolates from European wild snakes reside in a clade distinct from the North American isolates examined. These genetic and phenotypic differences indicate that the European isolates represent novel strains of O. ophiodiicola. Further work is required to understand the individual and population level impact of this pathogen in Europe.