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Sample records for european commission dg

  1. Preparing Teachers for Diversity: The Role of Initial Teacher Education. Annex 1 to the Final Report to DG Education, Youth, Sport and Culture of the European Commission

    ERIC Educational Resources Information Center

    European Commission, 2017

    2017-01-01

    This document, "Annex 1 to the Final Report to DG Education, Youth, Sport and Culture of the European Commission" is intended as a companion piece to European Commission report "Preparing Teachers for Diversity: The Role of Initial Teacher Education. Final Report". It contains country fiches which are overviews of available…

  2. Preparing Teachers for Diversity: The Role of Initial Teacher Education. Annex 2 To the Final Report to DG Education, Youth, Sport and Culture of the European Commission. Case Study Summaries

    ERIC Educational Resources Information Center

    European Commission, 2017

    2017-01-01

    "Preparing Teachers for Diversity: The Role of Initial Teacher Education. Annex 2 To the Final Report to DG Education, Youth, Sport and Culture of the European Commission. Case Study Summaries" is designed as a companion document to the final report "Preparing Teachers for Diversity: The Role of Initial Teacher Education. Final…

  3. Preparing Teachers for Diversity: The Role of Initial Teacher Education. Executive Summary of the Final Report to DG Education, Youth, Sport and Culture of the European Commission

    ERIC Educational Resources Information Center

    European Commission, 2017

    2017-01-01

    Although the cultural, linguistic and religious diversity found in European societies is not a new phenomenon, its nature is rapidly changing. Europe is becoming increasingly diverse due to intra-European mobility, international migration, including recently an increased influx of refugees and asylum-seekers. These societal changes create both…

  4. Impact assessment and policy learning in the European Commission

    SciTech Connect

    Ruddy, Thomas F. Hilty, Lorenz M.

    2008-02-15

    Governance for sustainable development requires policy coherence and Environmental Policy Integration, which are being hindered by difficulties coordinating the two separate impact assessment processes being conducted in the European Commission. One of them, the Commission-wide Impact Assessment process, looks primarily at EU-internal impacts, whereas the other one, Sustainability Impact Assessment (SIA) in DG Trade, looks outward to other countries and intergovernmental organizations. Ideally, the two processes should complement one another, especially as the two are set to continue being done in parallel. The paper uses a case study of the reform of the European sugar regime under a World Trade Organization ruling to demonstrate how the two impact assessment processes could better complement one another. Feedback from the experience had with existing trade agreements could then promote policy learning and inform the negotiations on new agreements. The number of new bilateral and Regional Trade Agreements is expected to continue rising, thus increasing the importance of the Commission-wide Impact Assessment process required for them.

  5. European Commission activities in eHealth.

    PubMed

    Olsson, Silas; Lymberis, Andreas; Whitehouse, Diane

    2004-12-01

    Health-care is an information-intensive and knowledge-demanding sector, which is why eHealth solutions are so important in this field. The European Commission (EC) has been initiating and funding research and development activities regarding Information and Communication Technologies (ICT) for health, or "eHealth", since 1988. These programmes covered priority topics like electronic health-care records, regional and national health networks, telemedicine in homecare and care-at-the-point-of-need to support continuity of care concepts, systems to support people to stay healthy, and systems and tools to support health professionals to work more efficiently and safely on patients. During the 15-year span of the programmes, the European Union (EU) has contributed about 500 million Euro to approximately 400 R&D projects, support activities, best practice and studies covering technical, clinical, ethical, legal, organisational and market issues. eHealth has shown proven benefits in application fields like improved access to care, care at the point-of-need, citizen-centred care, improved quality and cost containment. Such applications were on show at the EU High Level eHealth Conferences in Brussels, Belgium, in 2003, and in Cork, Ireland, in 2004. eHealth is now on the governmental agenda of EU Member States to be implemented on a broader scale. In line with this development, the Commission has taken a number of policy initiatives. A European Union Action Plan for a European eHealth Area was published by the Commission in April 2004 and endorsed by the EU health ministers in June 2004. This means that, for the first time, Europe has a coherent agenda for the implementation of eHealth. This report will concentrate on eHealth activities initiated by the Information Society Directorate-General of the European Commission.

  6. Commissioning for the European XFEL facility

    NASA Astrophysics Data System (ADS)

    Nölle, D.

    2017-06-01

    The European XFEL is a 4th generation light source based on the Self Amplified Spontaneous Emission (SASE) FreeElectron-Laser concept. It is currently being commissioned in North- Germany. The core installation is a 17.5 GeV superconducting accelerator driving 3 SASE lines with photon energies from 1 to beyond 20 keV range with a maximum of 27.000 pulses per second. The international facility is organized as a limited liability company with shareholders from the contributing countries. DESY has taken over the leadership of the accelerator construction consortium, and will be in charge of the operation of the accelerator complex. The facility was set up with contributions from the 11 shareholder countries, either being hardware systems and/or staff or cash contributions. The construction is almost complete, and the commissioning phase has started by the end of 2015. This contribution will report the status of the accelerator complex with emphasis on the commissioning of the accelerator and an outlook to the commissioning of the SASE 1 FEL line.

  7. Life cycle thinking in waste management: summary of European Commission's Malta 2005 workshop and pilot studies.

    PubMed

    Koneczny, Karol; Pennington, David W

    2007-01-01

    Life cycle thinking is essential to consider the implications of different waste management systems beyond their traditional regional boundaries. Building on data provided by representatives of Bulgaria, Cyprus, Czech Republic, Hungary, Lithuania, Malta, Poland, Romania, and Slovakia, the European Commission's DG JRC conducted a series of life cycle pilot studies in the context of municipal waste management. The results were presented in a JRC workshop in Malta, where the government representatives also outlined their national strategies focusing on the main related achievements. Proposed follow-up activities include a close interaction with the Commission's project, the European Platform on Life Cycle Assessment, to develop straightforward European life cycle guidelines for the management of various wastes.

  8. Meeting DG's

    ScienceCinema

    None

    2016-07-12

    Le DG J.Adams commente les 3 thèmes de la réunion: 1.) le prochain DG du Cern (qui sera H.Schopper) 2.) le LEP 3.) les conclusions du comité des finances concernant salaires, allocations etc. Discussion entre le DG J.Adams, Mons.Ullmann, chef du personel et l'auditoire

  9. A New Impetus for European Youth. European Commission White Paper.

    ERIC Educational Resources Information Center

    Commission of the European Communities, Brussels (Belgium).

    Despite their highly divergent situations, young people largely share the same values, ambitions, and difficulties. Despite the more complex social and economic context in which young Europeans are currently living, they are well equipped to adapt. National and European policymakers must facilitate this process of change by making young people…

  10. Research on photonic components: the perspective of the European Commission

    NASA Astrophysics Data System (ADS)

    Kalbe, Gustav

    2008-11-01

    The importance of photonic technologies for the European economy is recognized by the European Union and enjoys continued support. The mechanisms of the European Union to support research and development by introducing the "7th European Framework Program for Collaborative Research" are outlined. The topical content of the Framework Program is presented, as well as its implementation and in particular the support of photonic components related research and development. We will highlight the importance of the collaborative European effort and give examples of its impact. We will then provide an overview of the current topics supported by the European Commission. We will conclude by presenting the long term vision and giving indications on the likely research priorities for Photonic Components in the ICT Workprogram 2009-2010 of the 7th Framework Program (FP7).

  11. The INQUA Loess Commission as a Central European Enterprise

    NASA Astrophysics Data System (ADS)

    Smalley, Ian; Markovic, Slobodan; O'Hara-Dhand, Ken

    2010-03-01

    The International Union of Quaternary Research (INQUA) organized the study and consideration of the Quaternary Period (the last 2.6 million years in Earth's history) via a set of commissions, sub-commissions, working groups, projects and programmes. One of the most successful and best records was the Loess Commission (LC) which functioned assub-commission and then commission from 1961 to 2003, resulting in 40 years of useful activity. The history of the LC can be divided into three phases: 1, from 1961-1977 when the President was Julius Fink; 2, from 1977-1991, with President Marton Pecsi; 3, from 1991-2003 with Presidents An Zhi-Sheng and Ian Smalley. Fink, from Vienna, and Pecsi, from Budapest, gave the LC a distinctly Central European aspect. The nature of loess in Central Europe influenced the nature of the LC but the settings for phases 1 and 2 were quite distinct. Phase 1 was a small scale academic operation, carried out in German. As phase 2 began in 1977 the scope expanded and Central Europe became a base for worldwide loess studies. where the LC language changed to English. Phase 2 was run from a National Geographical Institute and demonstrated a different approach to loess research, although the basic programmes of continent-wide mapping and stratigraphy remained the same. The Commission benefited from this change of style and emphasis. In phase 3 the administration moved away from Central Europe but the Finkian ethos remained solid.

  12. The European Commission proposal for a marine strategy: lacking substance.

    PubMed

    Salomon, Markus

    2006-11-01

    The European Commission's proposed Marine Strategy constitutes a highly inadequate approach to long-term protection of the European Seas. The main problem with the strategy is the restriction to a proposed directive in which only EU Member States are placed under obligation to develop their own environmental objectives and marine protection activity programmes. This 'renationalisation' results in the exclusion of key policy areas like Common Agricultural Policy (CAP) and Common Fishery Policy in which the EU has centralised powers. Furthermore, there is no plan to refine EU environmental law relevant to marine protection and nor are there any provisions for the linking of EU-level action with the international conventions for the protection of the oceans.

  13. European Union energy policy integration: A case of European Commission policy entrepreneurship and increasing supranationalism.

    PubMed

    Maltby, Tomas

    2013-04-01

    Focusing on gas, this article explores the role of the European Commission in the process of European Union energy security policy development, and the extent to which the policy area is becoming increasingly supranational. Situating the article within the literature on agenda-setting and framing, it is argued that a policy window was opened as a result of: enlargement to include more energy import dependent states, a trend of increasing energy imports and prices, and gas supply disruptions. From the mid-2000s, the Commission contributed to a shift in political norms, successfully framing import dependency as a problem requiring an EU-level solution, based on the institution's pre-existing preferences for a diversified energy supply and internal energy market. Whilst Member States retain significant sovereignty, the Commission has achieved since 2006 creeping competencies in the internal, and to a lesser extent external, dimensions of EU energy policy.

  14. European Union energy policy integration: A case of European Commission policy entrepreneurship and increasing supranationalism

    PubMed Central

    Maltby, Tomas

    2013-01-01

    Focusing on gas, this article explores the role of the European Commission in the process of European Union energy security policy development, and the extent to which the policy area is becoming increasingly supranational. Situating the article within the literature on agenda-setting and framing, it is argued that a policy window was opened as a result of: enlargement to include more energy import dependent states, a trend of increasing energy imports and prices, and gas supply disruptions. From the mid-2000s, the Commission contributed to a shift in political norms, successfully framing import dependency as a problem requiring an EU-level solution, based on the institution’s pre-existing preferences for a diversified energy supply and internal energy market. Whilst Member States retain significant sovereignty, the Commission has achieved since 2006 creeping competencies in the internal, and to a lesser extent external, dimensions of EU energy policy. PMID:24926115

  15. European Commission project: European Guideline for Target Group-Oriented Psychosocial Aftercare-Implementation.

    PubMed

    Vymetal, Stepan; Deistler, Albert; Bering, Robert; Schedlich, Claudia; Rooze, Magda; Orengo, Francisco; Zurek, Gisela; Krtickova, Michaela

    2011-06-01

    After disasters, the individual health and well-being of first responders and affected population are affected for years. Therefore, psychosocial help is needed. Although most victims recover on their own, a minority of survivors, members of rescue teams, or relatives develop long-term, disaster-related psychic disorders, such as post-traumatic stress disorder (PTSD). This subgroup especially should receive timely and appropriate psychosocial help. Many European countries offer post-disaster psychosocial care from a variety of caregivers (i.e., professionals and volunteers, non-governmental organizations, church or commercial organizations). Therefore, European standards for providing post-disaster psychosocial support currently is required. This article describes the project European Guideline for Target Group-Oriented Psychosocial Aftercare-Implementation, supported by the European Commission.

  16. Mobility as a Continuum: European Commission Mobility Policies for Schools and Higher Education

    ERIC Educational Resources Information Center

    Dvir, Yuval; Yemini, Miri

    2017-01-01

    This study explores the rationale and aims of European Commission (EC) mobility programmes for schools and higher education systems, namely the Comenius and the European Action Scheme for the Mobility of University Students (ERASMUS) funding schemes. Our findings indicate that the aims, rationales and means of mobility programmes for the school…

  17. Mobility as a Continuum: European Commission Mobility Policies for Schools and Higher Education

    ERIC Educational Resources Information Center

    Dvir, Yuval; Yemini, Miri

    2017-01-01

    This study explores the rationale and aims of European Commission (EC) mobility programmes for schools and higher education systems, namely the Comenius and the European Action Scheme for the Mobility of University Students (ERASMUS) funding schemes. Our findings indicate that the aims, rationales and means of mobility programmes for the school…

  18. Commission Work Programme Relating to the Promotion of Innovation in Secondary Education in the European Community.

    ERIC Educational Resources Information Center

    Commission of the European Communities, Brussels (Belgium).

    The Commission of the European Communities (CEC) has proposed a program for practical cooperation among Member States in secondary education. The strategies and methods of cooperation developed in two previous action programs must be adapted to the evolving situation of the 1990s. Factors of particular importance are continuing structural change…

  19. [Environmental and occupational exposure to vitreous fibers: the initiatives of the European Commission].

    PubMed

    Aresini, G A

    1999-01-01

    The recent classification of a certain number of glass fibres by the European Commission within the framework of the Council Directive 67/548/CEE has reopened the debate on the carcinogenicity of these fibres at the level of the European Union. There is the risk of a law suit being field before the Court of Justice in Luxembourg against Germany, "guilty" of not having observed Community regulations. As regards worker protection, the recent Council Directive on chemical agents reviews the legal aspects concerning both preventive measures and the setting of limit values of occupational exposure.

  20. [The ethics review process in the Seventh Framework Programme of the European Commission].

    PubMed

    Pérez Blanco, V; Hirsch, F; González Pantaleón, P; Kritikos, M; Karatzas, I

    2010-01-01

    The Seventh Framework Programme of the European Commission (EC) is one of the most important instruments for public funding of research and technological development. Besides the scientific assessment of each proposal, the ethical issues raised in them are evaluated in accordance with the current European legislation and the ethical principles laid down in the international declarations supported by Member States. Such ethical review is organized by the "Governance and Ethics" Unit (Directorate-General for Research), although it is done by professionals from different sectors and backgrounds who register themselves voluntary in a database.

  1. Direct-to-consumer advertising of prescription drugs: European Commission persists in putting industry's interests first.

    PubMed

    2013-01-01

    In late September 2010, Members of the European Parliament (MEPs) issued their verdict on European Commission proposals aimed at lifting the ban on pharmaceutical companies communicating directly with the general public about prescription drugs. The MEPs were able to limit the scope of some of the more harmful aspects of these proposals, in particular by proposing that drug regulatory agencies should pre-screen the "information" produced by drug companies before it is made available to the public. In December 2010, faced with ongoing opposition from European Member States, the Commission appeared to back down, announcing that it was drawing up "amended proposals". They were publicly released in February 2012 but still leave the door open to direct-to-consumer advertising of prescription drugs, particularly "reminder advertising". As of 4 July 2012, the amended proposals had not yet been examined by Member States, thus obstructing the legislative process. Public health and management of the costs of social services for Member States are at stake. The Medicines in Europe Forum (MiEF) and the International Society of Drug Bulletins (ISDB) urge Member States to continue to refuse to examine the Commission's proposals, and have drawn up concrete counterproposals that would enable the general public to obtain relevant health information.

  2. Feedback from European Social Partners as Part of the Consultation on the Commission's Memorandum on Lifelong Learning. Supporting Document to the Communication from the Commission Making a European Area of Lifelong Learning a Reality.

    ERIC Educational Resources Information Center

    Commission of the European Communities, Brussels (Belgium). Directorate-General for Education and Culture.

    This document provides European social partners' responses to the Commission's memorandum on lifelong learning. Part 1, Opinion of the European Center of Enterprises, makes comments and proposals related to the memorandum's six key messages, which are new basic skills for all; more investment in human resources; innovation in teaching and…

  3. Comparative decline in funding of European Commission malaria vaccine projects: what next for the European scientists working in this field?

    PubMed

    Thøgersen, Regitze L; Holder, Anthony A; Hill, Adrian V S; Arnot, David E; Imoukhuede, Egeruan B; Leroy, Odile

    2011-09-01

    Since 2000, under the Fifth and subsequent Framework Programmes, the European Commission has funded research to spur the development of a malaria vaccine. This funding has contributed to the promotion of an integrated infrastructure consisting of European basic, applied and clinical scientists in academia and small and medium enterprises, together with partners in Africa. Research has added basic understanding of what is required of a malaria vaccine, allowing selected candidates to be prioritized and some to be moved forward into clinical trials. To end the health burden of malaria, and its economic and social impact on development, the international community has now essentially committed itself to the eventual eradication of malaria. Given the current tentative advances towards elimination or eradication of malaria in many endemic areas, malaria vaccines constitute an additional and almost certainly essential component of any strategic plan to interrupt transmission of malaria. However, funding for malaria vaccines has been substantially reduced in the Seventh Framework Programme compared with earlier Framework Programmes, and without further support the gains made by earlier European investment will be lost.

  4. The History of Soil Mapping and Classification in Europe: The role of the European Commission

    NASA Astrophysics Data System (ADS)

    Montanarella, Luca

    2014-05-01

    Early systematic soil mapping in Europe dates back to the early times of soil science in the 19th Century and was developed at National scales mostly for taxation purposes. National soil classification systems emerged out of the various scientific communities active at that time in leading countries like Germany, Austria, France, Belgium, United Kingdom and many others. Different scientific communities were leading in the various countries, in some cases stemming from geological sciences, in others as a branch of agricultural sciences. Soil classification for the purpose of ranking soils for their capacity to be agriculturally productive emerged as the main priority, allowing in some countries for very detailed and accurate soil maps at 1:5,000 scale and larger. Detailed mapping was mainly driven by taxation purposes in the early times but evolved in several countries also as a planning and management tool for farms and local administrations. The need for pan-European soil mapping and classification efforts emerged only after World War II in the early 1950's under the auspices of FAO with the aim to compile a common European soil map as a contribution to the global soil mapping efforts of FAO at that time. These efforts evolved over the next decades, with the support of the European Commission, towards the establishment of a permanent network of National soil survey institutions (the European Soil Bureau Network). With the introduction of digital soil mapping technologies, the new European Soil Information System (EUSIS) was established, incorporating data at multiple scales for the EU member states and bordering countries. In more recent years, the formal establishment of the European Soil Data Centre (ESDAC) hosted by the European Commission, together with a formal legal framework for soil mapping and soil classification provided by the INSPIRE directive and the related standardization and harmonization efforts, has led to the operational development of advanced

  5. Consultation Process on the European Commission's "Memorandum on Lifelong Learning": Analysis of National Reports. CEDEFOP Panorama Series.

    ERIC Educational Resources Information Center

    Ni Cheallaigh, Martina, Ed.

    This document presents outcomes of a review of the Memorandum on Lifelong Learning (LL) consultation reports from member states of the European Commission and EEA (European Economic Area) countries that collected all views on how best to make progress in implementing LL at local, regional, and national levels. Section 1 provides an overview of…

  6. Old wine in new bottles: Tobacco industry's submission to European Commission tobacco product directive public consultation

    PubMed Central

    Hiilamo, Heikki; Glantz, Stanton A.

    2015-01-01

    Between September and December 2010 the European Commission Health & Consumer Protection Directorate-General (DGSANCO) held a public consultation on a possible revision of the European Union Tobacco Products Directive (2001/37/EC). We used content analysis of the tobacco industry's and related parties' 300 submissions to the public consultation to determine if tobacco industry and its allies in Europe are prepared to reduce harm of the tobacco products as their public statements assert. The industry submission resorted to traditional tobacco industry arguments where illicit trade and freedom of choice were emphasized and misrepresented the conclusions of a DGSANCO-commissioned scientific report on smokeless tobacco products. Retailers and wholesalers referred to employment and economic growth more often than respondents from other categories. The pattern of responses in the submission differed dramatically from independent public opinion polls of EU citizens' support for tobacco control policies. None of the major tobacco manufacturers or their lobbying organizations supported any of the DGSANCO's proposed evidence based interventions (pictorial health warnings, plain packaging or point-of-sale display bans) to reduce harms caused by cigarette smoking. PMID:25467283

  7. Old wine in new bottles: tobacco industry's submission to European Commission tobacco product directive public consultation.

    PubMed

    Hiilamo, Heikki; Glantz, Stanton A

    2015-01-01

    Between September and December 2010 the European Commission Health & Consumer Protection Directorate-General (DGSANCO) held a public consultation on a possible revision of the European Union Tobacco Products Directive (2001/37/EC). We used content analysis of the tobacco industry's and related parties' 300 submissions to the public consultation to determine if tobacco industry and its allies in Europe are prepared to reduce harm of the tobacco products as their public statements assert. The industry submission resorted to traditional tobacco industry arguments where illicit trade and freedom of choice were emphasized and misrepresented the conclusions of a DGSANCO-commissioned scientific report on smokeless tobacco products. Retailers and wholesalers referred to employment and economic growth more often than respondents from other categories. The pattern of responses in the submission differed dramatically from independent public opinion polls of EU citizens' support for tobacco control policies. None of the major tobacco manufacturers or their lobbying organizations supported any of the DGSANCO's proposed evidence based interventions (pictorial health warnings, plain packaging or point-of-sale display bans) to reduce harms caused by cigarette smoking. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  8. Status and commissioning results of the helium refrigerator plant for the European XFEL

    NASA Astrophysics Data System (ADS)

    Blum, L.; Wilhelm, H.; Petersen, B.; Schnautz, T.

    2015-12-01

    The European XFEL project is under construction at DESY in Germany. The superconducting XFEL linac is supplied by the XFEL helium refrigerator plant. This plant consists of two existing refrigerators, which were in service for the HERA storage ring until 2007. Since the XFEL linear accelerator requires cryogenic cooling at 2K, the existing cryogenic infrastructure had to be modified. Two of the three existing HERA helium refrigerators were required to cover the design heat load of the XFEL-linac. The refrigerator infrastructure was extended by a 2 K cooling loop, whose main component consists of a string of four cold compressors generating approximately 1.7 kW isothermal cooling capacity at 2K. The step by step commissioning and extension of the accelerator as well as the future upgrade option of the heat load demanded an extremely high turn down ability, a particular challenge for 2K cold compressor strings. The commissioning of the helium refrigerator infrastructure is underway and should be completed soon. The current status of this project, commissioning results and particular challenges are presented.

  9. 75 FR 54918 - Draft Regulatory Guide, DG-1247, “Design-Basis Hurricane and Hurricane Missiles for Nuclear Power...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... COMMISSION Draft Regulatory Guide, DG-1247, ``Design-Basis Hurricane and Hurricane Missiles for Nuclear Power... issuance and availability of Draft Regulatory Guide (DG)--1247, ``Design-Basis Hurricane and Hurricane... permits and licenses. The draft regulatory guide (DG), entitled, ``Design-Basis Hurricane and...

  10. Is "Better Regulation" Possible? Formal and Substantive Quality in the Impact Assessments in Education and Culture of the European Commission

    ERIC Educational Resources Information Center

    Souto-Otero, Manuel

    2013-01-01

    This article explores the initial results produced by the European Commission's "better regulation agenda", which aims to stimulate productivity and employment, on the use of evidence and its potential to enhance democratic governance. The article finds that implausible rational models of policy making dictate the ways in which the…

  11. The Institutional vs. the Academic Definition of the Quality of Work Life. What Is the Focus of the European Commission?

    ERIC Educational Resources Information Center

    Royuela, Vicente; Lopez-Tamayo, Jordi; Surinach, Jordi

    2008-01-01

    In recent years, we have seen how the quality of work life has been focused and defined by the European Commission (EC). In our study we compare the EC definition with the academic one and try to see how close they are. We also analyse the possibility of applying the institutional definition to the Spanish case through the development of specific…

  12. Good laboratory practice in the European Community. Role of the commission and the member states: external aspects.

    PubMed

    Berend, Klaus

    2002-01-01

    The paper recalls the history of the development of the OECD principles of good laboratory practice (GLP) and explains why the European Community has a role to play in the area of GLP. It presents briefly the current legal framework in the European Community (Directives 87/18/EEC and 88/320/EEC) and describes the role of the Commission and the member states in the practical implementation of the GLP principles within the European Community. Impacts of GLP on the relations of the European Community with third countries, both within the framework of the OECD and through bilateral trade agreements (mutual recognition agreements, MRA) based on article 133 of the treaty establishing the European Community, are then examined in greater detail.

  13. Testing patients during seizures: A European consensus procedure developed by a joint taskforce of the ILAE - Commission on European Affairs and the European Epilepsy Monitoring Unit Association.

    PubMed

    Beniczky, Sándor; Neufeld, Miri; Diehl, Beate; Dobesberger, Judith; Trinka, Eugen; Mameniskiene, Ruta; Rheims, Sylvain; Gil-Nagel, Antonio; Craiu, Dana; Pressler, Ronit; Krysl, David; Lebedinsky, Angelina; Tassi, Laura; Rubboli, Guido; Ryvlin, Philippe

    2016-09-01

    There is currently no international consensus procedure for performing comprehensive periictal testing of patients in the epilepsy monitoring units (EMUs). Our primary goal was to develop a standardized procedure for managing and testing patients during and after seizures in EMUs. The secondary goal was to assess whether it could be implemented in clinical practice (feasibility). A taskforce was appointed by the International League Against Epilepsy (ILAE)-Commission on European Affairs and the European Epilepsy Monitoring Unit Association, to develop a standardized ictal testing battery (ITB) based on expert opinion and experience with various local testing protocols. ITB contains a comprehensive set of 10 items that evidence the clinically relevant semiologic features, and it is adaptive to the dynamics of the individual seizures. The feasibility of the ITB was prospectively evaluated on 250 seizures from 152 consecutive patients in 10 centers. ITB was successfully implemented in clinical practice in all 10 participating centers and was considered feasible in 93% of the tested seizures. ITB was not feasible for testing seizures of very short duration.

  14. Public health ethical perspectives on the values of the European Commission's White Paper "Together for Health".

    PubMed

    Schröder-Bäck, Peter; Clemens, Timo; Michelsen, Kai; Schulte in den Bäumen, Tobias; Sørensen, Kristine; Borrett, Glenn; Brand, Helmut

    2012-06-01

    In 2007 the European Commission issued the White Paper: "Together for Health". Considered the EU Health Strategy for the years 2008-2013, it offers the cornerstones for setting priorities in EU health actions. The public health framework offered in this strategy is explicitly built on shared values--including the overarching values of universality, access to good quality care, equity and solidarity that reacted to certain health care challenges within the EU. This article analyses the Health Strategy via its ethical scope and considers implications for future health policy making. The Health Strategy and related documents are scrutinised to explore how the mentioned values are defined and enfolded. Additionally, scientific databases are searched for critical discussions of the value base of the Health Strategy. The results are discussed and reasoned from a public health ethical perspective. The Health Strategy is barely documented and discussed in the scientific literature. Furthermore, no attention was given to the value base of the Health Strategy. Our analysis shows that the mentioned values are particularly focussed on health care in general rather than on public health in particular. Besides this, the given values of the Health Strategy are redundant. An additional consideration of consequentialist public health ethics values would normatively strengthen a population-based health approach of EU health policy making.

  15. Environmental risk assessment of medicinal products for human use according to European Commission recommendations.

    PubMed

    Huschek, Gerd; Hansen, Peter D; Maurer, Hans H; Krengel, Dietmar; Kayser, Anja

    2004-06-01

    Presented here, based on new recommendations of the European Commission, is an environmental risk assessment (ERA) of a selected group of pharmaceuticals for Phase I, environmental exposure assessment, and Phase II Tier A, initial environmental fate and effect analysis. This pharmaceutical group is composed of the 111 highest-selling human drug substances that have annual sales in Germany of more than 5,000 kg. The data required for this ERA came from analyzing: (1) sales annually (in kg or IU) of the 2671 active pharmaceutical drug substances (2001) on the German market in all medicinal products sold by pharmacies (with and without prescriptions) and used in hospitals in 1996-2001; (2) the use pattern of drug substances as categorized according to Anatomical Therapeutic Chemical (ATC) classification indexes ATC3 and ATC7; (3) data for excretion, toxicity, and metabolites of the 111 selected human drug substances; (4) the physicochemical properties of these substances; and (5) the degradability of selected drug substances in sewage treatment plants (STPs) by using a validated and accredited liquid chromatography-electrospray ionization tandem mass spectrometry method. A correction factor for the pharmaceutical therapeutic (PT) activity of metabolites, the PT(Index) (excretion rate/100) for drug substances and PT active metabolites was established to refine the predicted environmental concentration (PEC(SURFACEWATER)). A refinement of the PEC(SURFACEWATER) was carried out with the market penetration factor of the human drug substances in Germany. In addition, for effect analysis the predicted no-effects concentration (PNEC) was calculated using assessment factors. The estimated PEC results were validated with the exposure results of effluents of the STPs. All results on ERA of drug substances have been documented in a Microsoft Access 2000 database.

  16. LCT for the European data relay system: in orbit commissioning of the Alphasat and Sentinel 1A LCTs

    NASA Astrophysics Data System (ADS)

    Heine, F.; Mühlnikel, G.; Zech, H.; Tröndle, D.; Seel, S.; Motzigemba, M.; Meyer, R.; Philipp-May, S.; Benzi, E.

    2015-03-01

    The European Data Relay System (EDRS) relies on optical communication links between Low Earth Orbit (LEO) and geostationary (GEO) spacecrafts. Data transmission at 1.8 Gbps between the S/Cs will be applied. EDRS is foreseen to go into operation in 2015. As a precursor to the EDRS GEO Laser Communication Terminals (LCT), an LCT is embarked on the Alphasat GEO S/C. Sentinel 1A is a LEO earth observation satellite as part of ESAs Copernicus program and carries an LCT on board. Both the Alphasat and the Sentinel 1A LCT have completed their individual in orbit commissioning and a joint link commissioning phase, with first LEO to GEO optical communication links in 2014. In this presentation, the design principle of the LCT applied for EDRS will be investigated. The most recent results of the in-orbit link commissioning phase of the LCTs on board of Alphasat and Sentinel 1A will be presented.

  17. The European Social Fund: The Commission, the Member State and Levels of Governance

    ERIC Educational Resources Information Center

    Brine, Jacqueline

    2004-01-01

    The European Social Fund (ESF) is the European Union structural fund that redistributes funds to facilitate vocational education and training (VET). With the exception of the Common Agricultural Policy it is the EU's largest instrument for redistribution. Currently linked to the European Employment Strategy it match-funds, and through its…

  18. The European Social Fund: The Commission, the Member State and Levels of Governance

    ERIC Educational Resources Information Center

    Brine, Jacqueline

    2004-01-01

    The European Social Fund (ESF) is the European Union structural fund that redistributes funds to facilitate vocational education and training (VET). With the exception of the Common Agricultural Policy it is the EU's largest instrument for redistribution. Currently linked to the European Employment Strategy it match-funds, and through its…

  19. Beam commission of the high intensity proton source developed at INFN-LNS for the European Spallation Source

    NASA Astrophysics Data System (ADS)

    Neri, L.; Celona, L.; Gammino, S.; Miraglia, A.; Leonardi, O.; Castro, G.; Torrisi, G.; Mascali, D.; Mazzaglia, M.; Allegra, L.; Amato, A.; Calabrese, G.; Caruso, A.; Chines, F.; Gallo, G.; Longhitano, A.; Manno, G.; Marletta, S.; Maugeri, A.; Passarello, S.; Pastore, G.; Seminara, A.; Spartà, A.; Vinciguerra, S.

    2017-07-01

    At the Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud (INFN-LNS) the beam commissioning of the high intensity Proton Source for the European Spallation Source (PS-ESS) started in November 2016. Beam stability at high current intensity is one of the most important parameter for the first steps of the ongoing commissioning. Promising results were obtained since the first source start with a 6 mm diameter extraction hole. The increase of the extraction hole to 8 mm allowed improving PS-ESS performances and obtaining the values required by the ESS accelerator. In this work, extracted beam current characteristics together with Doppler shift and emittance measurements are presented, as well as the description of the next phases before the installation at ESS in Lund.

  20. Educational Innovations in Finnish and European Contexts: An Analysis of the Aims and Outcomes of "The European Observatory" of the European Commission (1994-1998). Research Report 200.

    ERIC Educational Resources Information Center

    Tella, Seppo; Tirri, Kirsi

    The purpose of this document is to analyze some of the major developments and research findings of the European Observatory of Innovations in Education and Training (1994-1998). The Observatory was a consortium of 13 member countries of the European Union serving as a European network of researchers and educators in the field of comparative…

  1. Electromagnetic fields: activities in the European Commission with a focus on research projects and the Scientific Committee of Emerging and Newly Identified Health Risks (SCENIHR).

    PubMed

    Meroni, Donata; Schreck, Stefan

    2015-09-01

    The article summarizes the main activities of the European Commission concerning electromagnetic fields. It explains also the regulatory context, with a special focus on past and current research projects funded by the European Union and the role of the SCENIHR in assessing risks related to EMF. Main conclusions of the SCENIHR opinion adopted in 2015 on EMF are reported.

  2. 75 FR 36445 - Draft Regulatory Guide, DG-4018, “Constraint on Releases of Airborne Radioactive Materials To the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-25

    ... COMMISSION Draft Regulatory Guide, DG-4018, ``Constraint on Releases of Airborne Radioactive Materials To the... of Airborne Radioactive Materials to the Environment for Licensees Other than Power Reactors.'' This....resource@nrc.gov . The Draft Regulatory Guide, DG-4018, ``Constraint on Releases of Airborne Radioactive...

  3. Assessing the Impacts of Revising the Tobacco Products Directive: Study to Support a DG SANCO Impact Assessment.

    PubMed

    Tiessen, Jan; Hunt, Priscillia; Celia, Claire; Fazekas, Mihaly; de Vries, Han; Staetsky, Laura; Diepeveen, Stephanie; Rabinovich, Lila; Ridsdale, Helen; Ling, Tom

    2011-01-01

    Tobacco use is one of the largest avoidable causes of morbidity and premature death in the EU. Whilst smoking prevalence in the EU has been declining over the past 30 years, smoking has remained more prevalent among men than women in the EU-27, with some of the new Member States reporting the widest gaps between male and female smokers. For young smokers (13 to 15 years old) this situation is somewhat reversed, with slightly more girls than boys smoking. Against this background, the European Commission Directorate-General for Health and Consumer Protection (DG SANCO) considered a revision of the Tobacco Products Directive 2001/37/EC across five general areas: scope of the directive, labelling requirements, registration and market control fees, ingredients, and sales arrangements. More specifically, the types of policy options under consideration included (but were not limited to): an increase of warning label sizes on the back of packaging to 100%, a restriction for the display of products at retail outlets and an introduction of additional measurement method for TNCO (the modified ISO method) with maximum limits set accordingly. DG SANCO commissioned RAND Europe to provide support in assessing the potential health, macroeconomic, and compliance cost and administrative burden impacts of revising the Tobacco Products Directive. In addition to assessing impacts, the study provides an up-to-date overview of the evidence and basis for current tobacco product regulation that may be of interest to a wider audience interested in tobacco control policies.

  4. [The EU law on genetically modified organisms: the European Commission changes the strategy in order to allow, restrict, or prohibit its culture].

    PubMed

    González Vaqué, Luis

    2010-01-01

    On July 13 2010, the European Commission adopted a series of measures which outline a new approach on Genetically Modified Organisms (GMOs) cultivation in the Member States. This proposal, which still retains the basis of the existing science-based GMO authorisation system, will be implemented through: a Communication from the Commission, explaining the new approach on the freedom for Member States to decide on the cultivation of genetically modified crops; the "Proposal for a Regulation of the European Parliament and of the Council amending Directive 2001/18/EC as regards the possibility for the Member States to restrict or prohibit the cultivation of GMOs in their territory"; and a new "European Commission Recommendation (2010/C 200/01) of 13 July 2010 on guidelines for the development of national co-existence measures to avoid the unintended presence of GMOs in conventional and organic crops".

  5. Astrobiology Road Mapping (AstRoMap) - A project within FP7 of the European Commission: First results

    NASA Astrophysics Data System (ADS)

    Gomez-Gomez, Felipe; Capria, Maria Teresa; Palomba, Ernesto; Walter, Nicolas; Rettberg, Petra; Muller, Christian; Horneck, Gerda

    AstRoMap (Astrobiology and Planetary Exploration Road Mapping) is a funded project formulated in the 5th Call of the European Commission FP7 framework. The main objectives of the AstRoMap are: 1. Identify the main astrobiology issues to be addressed by Europe in the next decades in relation with space exploration 2. Identify potential mission concepts that would allow addressing these issues 3. Identify the technology developments required to enable these missions 4. Provide a prioritized roadmap integrating science and technology activities as well as ground-based approach 5. Map scientific knowledge related to astrobiology in Europe To reach those objectives, AstRoMap is executed within the following steps: 1. Community consultation. In order to map the European astrobiology landscape and to provide a collaborative networking platform for this community, the AstRoMap project hosts a database of scientists (European and beyond) interested in astrobiology and planetary exploration (see: http://www.astromap.eu/database.html). It reflects the demography and the research and teaching activities of the astrobiology community, as well as their professional profiles and involvement in astrobiology projects. Considering future aspects of astrobiology in Europe, the need for more astrobiology-dedicated funding programmes at the EU level, especially for cross-disciplinary groups, was stressed. This might eventually lead to the creation of a European laboratory of Astrobiology, or even of a European Astrobiology Institute. 2. Workshops organisation. On the basis of the feedbacks from the community consultation, the potential participants and interesting topics are being identified to take part in the following workshops: 1-. Origin of organic compounds, steps to life; 2. Physico-chemical boundary conditions for habitability 3. Biosignatures as facilitating life detection 4. Origin of the Solar system 3. Astrobiology road-mapping. Based on the results and major conclusions

  6. Combining ISO/IEC 17025:2005 and European Commission Decision 2002/657 audit requirements: a practical way forward.

    PubMed

    Kay, Jack F

    2012-08-01

    Laboratories involved in the analyses of veterinary drug residues are under increasing pressure to demonstrate that they produce meaningful and reliable data. Quality assurance and quality control systems are implemented in laboratories to provide evidence of this and these are subject to external assessment to ensure that they are effective. Audits to ISO/IEC 17025:2005, an internationally accepted standard, and subsequent accreditation provide laboratories and their customers with a degree of assurance that the laboratories are operating in control and the data they report can be relied on. However, national or regional authorities may place additional requirements on laboratories to ensure quality data are reported. For example, in the European Union, all official control laboratories involved in veterinary drug residue analyses must also meet the requirements of European Commission Decision 2002/657/EC which sets performance criteria for analytical methods used in this area and these are subject to additional audits by national or regional authorities. All audits place considerable time and resource demands on laboratories and this paper discusses the burden audits place on laboratories and describes a UK initiative to combine these audits to the benefit of both the regulatory authority and the laboratory.

  7. DEVELOPMENT OF HFE SECTIONS OF DG-1145.

    SciTech Connect

    HIGGINS,J.C.; OHARA, J.M.; BONGARRA, J.

    2007-03-26

    For the licensing of the current fleet of commercial nuclear power plants (NPPs), the Nuclear Regulatory Commission (NRC) used two key documents, NUREG-0800 and Regulatory Guide (RG) 1.70. RG 1.70 provided guidance to applicants on the contents needed in their Safety Analysis Reports (SARs) submitted as part of their application to construct or operate an NPP. NUREG-0800, the NRC Standard Review Plan (SRP), provides guidance to the NRR staff reviewers on performing their safety reviews of these applications. As part of the preparation for a new wave of improved NPP designs the NRC is in the process of updating the SRP and is also developing a new RG designated as draft RG or DG-1145, ''Combined License Applications for Nuclear Power Plants (LWR Edition).'' This will eventually become RG 1.206 and will take the place of RG 1.70. This will provide guidance for combined license (COL) applicants, as well as for other 10CFR Part 52 variations that are permitted.

  8. Is dental amalgam safe for humans? The opinion of the scientific committee of the European Commission

    PubMed Central

    2011-01-01

    It was claimed by the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR)) in a report to the EU-Commission that "....no risks of adverse systemic effects exist and the current use of dental amalgam does not pose a risk of systemic disease..." [1, available from: http://ec.europa.eu/health/ph_risk/committees/04_scenihr/docs/scenihr_o_016.pdf]. SCENIHR disregarded the toxicology of mercury and did not include most important scientific studies in their review. But the real scientific data show that: (a) Dental amalgam is by far the main source of human total mercury body burden. This is proven by autopsy studies which found 2-12 times more mercury in body tissues of individuals with dental amalgam. Autopsy studies are the most valuable and most important studies for examining the amalgam-caused mercury body burden. (b) These autopsy studies have shown consistently that many individuals with amalgam have toxic levels of mercury in their brains or kidneys. (c) There is no correlation between mercury levels in blood or urine, and the levels in body tissues or the severity of clinical symptoms. SCENIHR only relied on levels in urine or blood. (d) The half-life of mercury in the brain can last from several years to decades, thus mercury accumulates over time of amalgam exposure in body tissues to toxic levels. However, SCENIHR state that the half-life of mercury in the body is only "20-90 days". (e) Mercury vapor is about ten times more toxic than lead on human neurons and with synergistic toxicity to other metals. (f) Most studies cited by SCENIHR which conclude that amalgam fillings are safe have severe methodical flaws. PMID:21232090

  9. Opportunities for Information Technology-Based Advanced Educational Technologies. Final Report for the Commission of European Communities. Volume 1: Executive Summary; Volume 2: Main Report; Volume 3: Annexes.

    ERIC Educational Resources Information Center

    Zorkoczy, Peter; And Others

    This three volume report describes a study that addressed the potential impact of information technology (IT)-based educational technology on the challenges facing the continuing education and vocational, industrial, and professional training sector of the Commission of European Communities member countries, and appropriate leading-edge…

  10. Development status of the X-ray beam diagnostics devices for the commissioning and user operation of the European XFEL

    NASA Astrophysics Data System (ADS)

    Grünert, Jan; Buck, Jens; Freund, Wolfgang; Ozkan, Cigdem; Molodtsov, Serguei

    2013-03-01

    X-ray Free-Electron-Lasers (XFEL) as the Linac Coherent Light Source (LCLS) in the USA, SACLA in Japan, and the European XFEL under construction in Germany are 4th generation light sources which allow research of at the same time extremely small structures (Ångström resolution) and extremely fast phenomena (femtosecond resolution). Unlike the pulses from a conventional optical laser, the radiation in these sources is created by the Self-Amplified Spontaneous Emission (SASE) process when electron bunches pass through very long segmented undulators. The shot noise at the origin of this process leads to significant pulse-to-pulse variations of pulse intensity, spectrum, wavefront, temporal properties etc. so that for user experiments an online monitoring of these properties is mandatory. Also, the adjustment of the long segmented undulators requires dedicated diagnostics such as an undulator commissioning spectrometer and spontaneous radiation analysis. The extremely high brilliance and resulting single-shot damage issue are difficult to handle for any XFEL diagnostics. Apart from the large energy range of operation of the facility from 280 eV to 25 keV in FEL fundamental, the particular challenge for the European XFEL diagnostics is the high intra bunch train photon pulse repetition rate of 4.5 MHz, potentially causing additional damage by high heat loads and making shot-to-shot diagnostics very demanding. This contribution reports on the facility concepts, recent progress in instrumentation development, and the optimization of diagnostics performance with respect to resolution/accuracy, shot-to-shot capabilities and energy range.

  11. Bayesian Inference for Time Trends in Parameter Values: Case Study for the Ageing PSA Network of the European Commission

    SciTech Connect

    Dana L. Kelly; Albert Malkhasyan

    2010-06-01

    There is a nearly ubiquitous assumption in PSA that parameter values are at least piecewise-constant in time. As a result, Bayesian inference tends to incorporate many years of plant operation, over which there have been significant changes in plant operational and maintenance practices, plant management, etc. These changes can cause significant changes in parameter values over time; however, failure to perform Bayesian inference in the proper time-dependent framework can mask these changes. Failure to question the assumption of constant parameter values, and failure to perform Bayesian inference in the proper time-dependent framework were noted as important issues in NUREG/CR-6813, performed for the U. S. Nuclear Regulatory Commission’s Advisory Committee on Reactor Safeguards in 2003. That report noted that “industry lacks tools to perform time-trend analysis with Bayesian updating.” This paper describes an application of time-dependent Bayesian inference methods developed for the European Commission Ageing PSA Network. These methods utilize open-source software, implementing Markov chain Monte Carlo sampling. The paper also illustrates the development of a generic prior distribution, which incorporates multiple sources of generic data via weighting factors that address differences in key influences, such as vendor, component boundaries, conditions of the operating environment, etc.

  12. Patients' understanding of risk associated with medication use: impact of European Commission guidelines and other risk scales.

    PubMed

    Berry, Dianne C; Raynor, D K; Knapp, Peter; Bersellini, Elisabetta

    2003-01-01

    Patients want and need comprehensive and accurate information about their medicines so that they can participate in decisions about their healthcare. In particular, they require information about the likely risks and benefits that are associated with the different treatment options. However, to provide this information in a form that people can readily understand and use is a considerable challenge to healthcare professionals. One recent attempt to standardise the language of risk has been to produce sets of verbal descriptors that correspond to specific probability ranges, such as those outlined in the European Commission (EC) Pharmaceutical Committee guidelines in 1998 for describing the incidence of adverse effects. This paper provides an overview of a number of studies involving members of the general public, patients, and hospital doctors, that evaluated the utility of the EC guideline descriptors (very common, common, uncommon, rare, very rare). In all studies it was found that people significantly over-estimated the likelihood of adverse effects occurring, given specific verbal descriptors. This in turn resulted in significantly higher ratings of their perceived risks to health and significantly lower ratings of their likelihood of taking the medicine. Such problems of interpretation are not restricted to the EC guideline descriptors. Similar levels of misinterpretation have also been demonstrated with two other recently advocated risk scales (Calman's verbal descriptor scale and Barclay, Costigan and Davies' lottery scale). In conclusion, the challenge for risk communicators and for future research will be to produce a language of risk that is sufficiently flexible to take into account different perspectives, as well as changing circumstances and contexts of illness and its treatments. In the meantime, we urge the EC and other legislative bodies to stop recommending the use of specific verbal labels or phrases until there is a stronger evidence base to

  13. 75 FR 45677 - Draft Regulatory Guide, DG-1216,”Plant-Specific Applicability of Transition Break Size Specified...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-03

    ... COMMISSION Draft Regulatory Guide, DG-1216,''Plant-Specific Applicability of Transition Break Size Specified in 10 CFR 50.46a.'' Issuance, Availability; Extension of Comment Period AGENCY: Nuclear Regulatory Commission. ACTION: Extension of comment period. FOR FURTHER INFORMATION CONTACT: Robert Tregoning, U.S...

  14. Public funding for research on antibacterial resistance in the JPIAMR countries, the European Commission, and related European Union agencies: a systematic observational analysis.

    PubMed

    Kelly, Ruth; Zoubiane, Ghada; Walsh, Desmond; Ward, Rebecca; Goossens, Herman

    2016-04-01

    %) of 1208 projects funded at national level were within the area of therapeutics, versus 185 (15%) in transmission, 131 (11%) in diagnostics, 53 (4%) in interventions, and only 37 (3%) in environment and 39 (3%) in surveillance. This was the first systematic analysis of research funding of antibacterial resistance of this scale and scope, which relied on the availability and accuracy of data from organisations included. Large variation was seen between countries both in terms of number of projects and associated investment and across the six priority topics. To determine the future direction of JPIAMR countries a clear picture of the funding landscape across Europe and Canada is needed. Countries should work together to increase the effect of research funding by strengthening national and international coordination and collaborations, harmonising research activities, and collectively pooling resources to fund multidisciplinary projects. The JPIAMR have developed a publicly available database to document the antibacterial resistance research collected and can be used as a baseline to analyse funding from 2014 onwards. JPIAMR and the European Commission. Copyright © 2016 Kelly et al. Open Access article distributed under the terms of CC BY. Published by Elsevier Ltd.. All rights reserved.

  15. Public funding for research on antibacterial resistance in the JPIAMR countries, the European Commission, and related European Union agencies: a systematic observational analysis

    PubMed Central

    Kelly, Ruth; Zoubiane, Ghada; Walsh, Desmond; Ward, Rebecca; Goossens, Herman

    2016-01-01

    priority topics we found that 763 (63%) of 1208 projects funded at national level were within the area of therapeutics, versus 185 (15%) in transmission, 131 (11%) in diagnostics, 53 (4%) in interventions, and only 37 (3%) in environment and 39 (3%) in surveillance. Interpretation This was the first systematic analysis of research funding of antibacterial resistance of this scale and scope, which relied on the availability and accuracy of data from organisations included. Large variation was seen between countries both in terms of number of projects and associated investment and across the six priority topics. To determine the future direction of JPIAMR countries a clear picture of the funding landscape across Europe and Canada is needed. Countries should work together to increase the effect of research funding by strengthening national and international coordination and collaborations, harmonising research activities, and collectively pooling resources to fund multidisciplinary projects. The JPIAMR have developed a publicly available database to document the antibacterial resistance research collected and can be used as a baseline to analyse funding from 2014 onwards. Funding JPIAMR and the European Commission. PMID:26708524

  16. The prospects for using (Q)SARs in a changing political environment--high expectations and a key role for the European Commission's joint research centre.

    PubMed

    Worth, A P; Van Leeuwen, C J; Hartung, T

    2004-01-01

    Recent policy developments in the European union (EU) and within the Organisation for Economic Cooperation and Development (OECD) have placed increased emphasis on the use of structure-activity relationships (SARs) and quantitative structure-activity relationships (QSARs), collectively referred to as (Q)SARs, within various regulatory programmes for the assessment of chemicals and products. The most significant example within the EU is the European commission's proposal (of 29 October 2003) to introduce a new system for managing chemicals (called REACH), which calls for an increased use of (Q)SARs and other non-animal methods, especially for the assessment of low production volume chemicals. Another development within the EU is the Seventh Amendment to the Cosmetics Directive, which foresees the phasing out of animal testing on cosmetics, combined with the imposition of marketing bans on cosmetics that have been tested on animals after certain deadlines. At the same time, the Existing Chemicals programme within the OECD is investigating ways of increasing the use of chemical category approaches, which depend heavily on the use of (Q)SARs, activity-activity relationships and read-across. Such developments are placing an enormous challenge on industry, regulatory bodies, and on the European commission's Joint Research Centre (JRC), which is responsible for providing independent scientific advice to policy makers in the European Commission and the Member States. This paper reviews the different scientific and regulatory purposes for which reliable (Q)SARs could be used, and describes the current work of the JRC in providing scientific support for the development, validation and implementation of (Q)SARs.

  17. Preparing Teachers for Diversity: The Role of Initial Teacher Education. Annexes 3-6 to the Final Report to DG Education, Youth, Sport and Culture of the European Commission

    ERIC Educational Resources Information Center

    European Commission, 2017

    2017-01-01

    Research in initial teacher education (ITE) usually focuses on the policies and practices that shape the professional preparation of candidate teachers. There is a wide range of such policies and practices in Europe. One of the main reasons for such heterogeneity is that there is no agreement on what ITE curricula should particularly emphasise…

  18. The Commission of the European Communities and the Evolution of Common Policies: A Bibliographical Survey (1958-1974)

    ERIC Educational Resources Information Center

    Hopkins, M.

    1976-01-01

    Highlights those often fugitive documents that stand out as important landmarks in the evolution of common policies above the mass of technical and ephemeral documentation generated by the Commission. (Author)

  19. NoiseChem: an European Commission research project on the effects of exposure to noise and industrial chemicals on hearing and balance.

    PubMed

    Prasher, Deepak; Morata, Thais; Campo, Pierre; Fechter, Lawrence; Johnson, Ann-Christin; Lund, Soren Peter; Pawlas, Krystyna; Starck, Jukka; Sułkowski, Wiesław; Sliwinska-Kowalska, Mariola

    2002-01-01

    Exposure to multiple physical and chemical agents is common in occupational environments but workplace hazards and occupational safety criteria for combined exposures are lacking. NoiseChem is an European Commission research project examining the effects of exposure to noise and chemicals on hearing and balance. Partners in Sweden, Finland, France, Denmark, UK and Poland with expert guidance from partners in the USA will examine workers and study the mechanisms of action in animals to determine the levels of risk associated with joint exposure to noise and solvents. This paper briefly outlines the project details.

  20. Combined effect of CVR and penetration of DG in the voltage profile and losses of lowvoltage secondary distribution networks

    NASA Astrophysics Data System (ADS)

    Bokhari, Abdullah

    Demarcations between traditional distribution power systems and distributed generation (DG) architectures are increasingly evolving as higher DG penetration is introduced in the system. The concerns in existing electric power systems (EPSs) to accommodate less restrictive interconnection policies while maintaining reliability and performance of power delivery have been the major challenge for DG growth. In this dissertation, the work is aimed to study power quality, energy saving and losses in a low voltage distributed network under various DG penetration cases. Simulation platform suite that includes electric power system, distributed generation and ZIP load models is implemented to determine the impact of DGs on power system steady state performance and the voltage profile of the customers/loads in the network under the voltage reduction events. The investigation designed to test the DG impact on power system starting with one type of DG, then moves on multiple DG types distributed in a random case and realistic/balanced case. The functionality of the proposed DG interconnection is designed to meet the basic requirements imposed by the various interconnection standards, most notably IEEE 1547, public service commission, and local utility regulation. It is found that implementation of DGs on the low voltage secondary network would improve customer's voltage profile, system losses and significantly provide energy savings and economics for utilities. In a network populated with DGs, utility would have a uniform voltage profile at the customers end as the voltage profile becomes more concentrated around targeted voltage level. The study further reinforced the concept that the behavior of DG in distributed network would improve voltage regulation as certain percentage reduction on utility side would ensure uniform percentage reduction seen by all customers and reduce number of voltage violations.

  1. Investigating the Discourse on Social Cohesion in Relation to Innovation through the Vocabulary of European Commission Communications

    ERIC Educational Resources Information Center

    Villalba, Ernesto

    2008-01-01

    After the relaunch of the Lisbon Strategy, innovation has become one of the main areas of interest in the European Union (EU). In general terms, innovation is always seen as a driver of economic growth and a necessary element to achieve the strategic goal set by the EU in 2000 of becoming the most competitive knowledge-based economy. The strategic…

  2. Investigating the Discourse on Social Cohesion in Relation to Innovation through the Vocabulary of European Commission Communications

    ERIC Educational Resources Information Center

    Villalba, Ernesto

    2008-01-01

    After the relaunch of the Lisbon Strategy, innovation has become one of the main areas of interest in the European Union (EU). In general terms, innovation is always seen as a driver of economic growth and a necessary element to achieve the strategic goal set by the EU in 2000 of becoming the most competitive knowledge-based economy. The strategic…

  3. 77 FR 2236 - Airworthiness Directives; DG Flugzeugbau GmbH Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; DG Flugzeugbau GmbH... earlier NPRM for DG Flugzeugbau GmbH DG-500 Elan series sailplanes and Models DG-500M and DG-500MB powered... information identified in this proposed AD, DG Flugzeugbau GmbH, Otto-Lilienthal-Weg 2, 76646 Bruchsal...

  4. The fast-spectrum transmutation experimental facility FASTEF: Main design achievements (Part 1: Core and primary system) within the FP7-CDT collaborative project of the European Commission

    SciTech Connect

    De Bruyn, D.; Fernandez, R.; Mansani, L.; Woaye-Hune, A.; Sarotto, M.; Bubelis, E.

    2012-07-01

    MYRRHA (Multi-purpose hybrid Research Reactor for High-tech Applications) is the flexible experimental accelerator-driven system (ADS) in development at SCK CEN in replacement of its material testing reactor BR2. SCK CEN in association with 17 European partners from industry, research centres and academia, responded to the FP7 (Seventh Framework Programme) call from the European Commission to establish a Central Design Team (CDT) for the design of a Fast Spectrum Transmutation Experimental Facility (FASTEF) able to demonstrate efficient transmutation and associated technology through a system working in subcritical and/or critical mode. The project has started on April 01, 2009 for a period of three years. In this paper, we present the latest configuration of the reactor core and primary system. The FASTEF facility has evolved quite a lot since the intermediate reporting done at the ICAPP'10 and ICAPP'11 conferences 1 2. If it remains a small-scale facility, the core power amounts now up to 100 MWth in critical mode. In a companion paper 3, we present the concept of the reactor building and the plant layout. (authors)

  5. The Commission White Paper on a Strategy for a Future EU Chemicals Policy: the view of European companies of American parentage.

    PubMed

    Montfort, Jean-Philippe

    2003-04-01

    After years of good service, EU legislation on chemicals is currently subject to a major review. This process, initiated by the Council of Ministers at Chester in April 1998, will soon lead to new legislative proposals. In the meantime, a review of the Commission's White Paper on "Strategy for a Future Chemicals Policy," published in February 2001, clearly shows that the regulatory landscape in this area will be significantly reshaped and that a new burden will be imposed on industry to demonstrate that the production and use of chemicals indeed conform to high standards of protection of human health and the environment. In the view of industry, on both sides of the Atlantic, while the objectives of the proposed reform can be supported, the measures proposed in the White Paper to implement these objectives are not properly balanced and will lead to substantial societal and economic drawbacks, unless significant adjustments are made. The purpose of this article is to present the pitfalls and difficulties of the reform as they are perceived by the EU Committee of the American Chamber of Commerce in Brussels, an organization that regroups about 150 European companies of American parentage, belonging to a broad range of European business sectors, including producers and users of chemicals. In view of the transatlantic and cross-business character of its membership, the EU Committee offers a different perspective on the debate.

  6. e-Infrastructures for e-Sciences 2013 A CHAIN-REDS Workshop organised under the aegis of the European Commission

    NASA Astrophysics Data System (ADS)

    The CHAIN-REDS Project is organising a workshop on "e-Infrastructures for e-Sciences" focusing on Cloud Computing and Data Repositories under the aegis of the European Commission and in co-location with the International Conference on e-Science 2013 (IEEE2013) that will be held in Beijing, P.R. of China on October 17-22, 2013. The core objective of the CHAIN-REDS project is to promote, coordinate and support the effort of a critical mass of non-European e-Infrastructures for Research and Education to collaborate with Europe addressing interoperability and interoperation of Grids and other Distributed Computing Infrastructures (DCI). From this perspective, CHAIN-REDS will optimise the interoperation of European infrastructures with those present in 6 other regions of the world, both from a development and use point of view, and catering to different communities. Overall, CHAIN-REDS will provide input for future strategies and decision-making regarding collaboration with other regions on e-Infrastructure deployment and availability of related data; it will raise the visibility of e-Infrastructures towards intercontinental audiences, covering most of the world and will provide support to establish globally connected and interoperable infrastructures, in particular between the EU and the developing regions. Organised by IHEP, INFN and Sigma Orionis with the support of all project partners, this workshop will aim at: - Presenting the state of the art of Cloud computing in Europe and in China and discussing the opportunities offered by having interoperable and federated e-Infrastructures; - Exploring the existing initiatives of Data Infrastructures in Europe and China, and highlighting the Data Repositories of interest for the Virtual Research Communities in several domains such as Health, Agriculture, Climate, etc.

  7. FOREWORD: Workshop on Large Amplitude Waves and Fields in Plasmas, sponsored by the Commission of the European Communities

    NASA Astrophysics Data System (ADS)

    Bingham, R.; De Angelis, U.; Shukla, P. K.; Stenflo, L.

    1990-01-01

    cavities and their burn-out resulting in very strong turbulence. Remarkable agreement between the simulations and ionospheric modification experiments have been demonstrated. The articles presented also attempted to correlate the theories of parametric instabilities with experimental observations. The properties of plasma lenses used for focusing of high energy particle beams is also presented as part of the uses of the nonlinear plasmas. Self-organisation of plasmas resulting in coherent nonlinear structures and particle diffusion processes are reported. On the experimental side the nonlinear optics of plasmas as a new area of research has been reviewed. This is becoming an important area for research since it treats the plasma from the outset as a nonlinear medium. Experimental observations of phase conjugation of electromagnetic signals demonstrate once again the importance of the nonlinearities inherent in the interaction of large amplitude waves with plasmas. Finally the importance of turbulence in space plasmas is emphasized in a discussion of the auroral phenomenon, presenting the plasma physicists point of view on this topic. The workshop, attended by scientists from all over the world, stimulated a great deal of lively discussions about the theoretical foundations, experimental observations and interpretations together with computer simulation results on the physics of nonlinear plasma wave phenomena. The workshop was made possible by the kind support of Professors A Salam, L Bertocchi and M Hassan. We are grateful to them for giving us the opportunity to organize the workshop within the activities of the Spring College on Plasma Physics. Thanks are also due to the ICTP and the European Economic Community (EEC) for providing partial financial support. Finally, our most cordial thanks are extended to the invited speakers for coming to Trieste delivering excellent talks and enhancing the activity of the Spring College.

  8. The Degradation of dG Phosphoramidites in Solution.

    PubMed

    Hargreaves, John S; Kaiser, Robert; Wolber, Paul K

    2015-01-01

    The reaction of 2'-deoxynucleoside phosphoramidites with water is an important degradation reaction that limits the lifetimes of reagents used for chemical deoxyoligonucleotide synthesis. The hydrolysis of nucleoside phosphoramidites in solution has therefore been investigated. The degree of degradation depends not only on the presence of water but also on the specific nucleoside, 2'-deoxyguanosine (dG) being especially susceptible. Additionally, the nature of the group protecting the exocyclic amine on the nucleoside base strongly influences the rate of hydrolysis. For dG, the degradation is second order in phosphoramidite concentration, indicating autocatalysis of the hydrolysis reaction. Comparison of the degradation rates of dG phosphoramidites with different protecting groups as well as with phosphoramidites containing bases that are structurally similar to dG affords clues to the nature of how dG catalyzes its own destruction and indicates a direct correlation between ease of protecting group removal and propensity to undergo autocatalytic degradation.

  9. Waste Isolation Pilot Plant Materials Interface Interactions Test: Papers presented at the Commission of European Communities workshop on in situ testing of radioactive waste forms and engineered barriers

    SciTech Connect

    Molecke, M.A.; Sorensen, N.R.; Wicks, G.G.

    1993-08-01

    The three papers in this report were presented at the second international workshop to feature the Waste Isolation Pilot Plant (WIPP) Materials Interface Interactions Test (MIIT). This Workshop on In Situ Tests on Radioactive Waste Forms and Engineered Barriers was held in Corsendonk, Belgium, on October 13--16, 1992, and was sponsored by the Commission of the European Communities (CEC). The Studiecentrum voor Kernenergie/Centre D`Energie Nucleaire (SCK/CEN, Belgium), and the US Department of Energy (via Savannah River) also cosponsored this workshop. Workshop participants from Belgium, France, Germany, Sweden, and the United States gathered to discuss the status, results and overviews of the MIIT program. Nine of the twenty-five total workshop papers were presented on the status and results from the WIPP MIIT program after the five-year in situ conclusion of the program. The total number of published MIIT papers is now up to almost forty. Posttest laboratory analyses are still in progress at multiple participating laboratories. The first MIIT paper in this document, by Wicks and Molecke, provides an overview of the entire test program and focuses on the waste form samples. The second paper, by Molecke and Wicks, concentrates on technical details and repository relevant observations on the in situ conduct, sampling, and termination operations of the MIIT. The third paper, by Sorensen and Molecke, presents and summarizes the available laboratory, posttest corrosion data and results for all of the candidate waste container or overpack metal specimens included in the MIIT program.

  10. POLARIMETRY OF DG TAU AT 350 mum

    SciTech Connect

    Krejny, M.; Matthews, T. G.; Novak, G.; Cho, J.; Li, H.; Shinnaga, H.; Vaillancourt, J. E.

    2009-11-01

    We present the first 350 mum polarization measurement for the disk of the T Tauri star (TTS) DG Tau. The data were obtained using the SHARP polarimeter at the Caltech Submillimeter Observatory. We measured normalized Stokes parameters q= -0.0086 +- 0.0060 and u = -0.0012 +- 0.0061, which gives a 2sigma upper limit for the percent polarization of 1.7%. We obtain information about the polarization spectrum by comparing our 350 mum measurement with an 850 mum polarization detection previously published for this source. Comparing the two measurements in Stokes space (not in percent polarization) shows that the two data points are not consistent, i.e., either the degree of polarization or the angle of polarization (or both) must change significantly as one moves from 850 mum to 350 mum. This conclusion concerning the polarization spectrum disagrees with the predictions of a recent model for TTS disk polarization. We show that this discrepancy can be explained by optical depth effects. Specifically, we demonstrate that if one were to add more mass to the model disk, one would expect to obtain a model polarization spectrum in which the polarization degree falls sharply with increasing frequency, consistent with the observations at the two wavelengths. We suggest that multiwavelength polarimetry of TTS disk emission may provide a promising method for probing the opacity of TTS disks.

  11. 76 FR 76330 - Airworthiness Directives; DG Flugzeugbau GmbH Sailplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; DG Flugzeugbau GmbH... ] Flugzeugbau GmbH Models DG-500 Elan Orion sailplanes and DG-500M and DG-500MB powered sailplanes. This... identified in this proposed AD, contact DG Flugzeugbau GmbH, Otto-Lilienthal-Weg 2, 76646 Bruchsal, Federal...

  12. Declaration of the European Ministers of Vocational Education and Training, and the European Commission, Convened in Copenhagen on 29 and 30 November 2002, on Enhanced European Cooperation in Vocational Education and Training. "The Copenhagen Declaration."

    ERIC Educational Resources Information Center

    European Commission, Brussels (Belgium).

    Enhanced cooperation in vocational education and training (VET) will be an important contribution toward ensuring a successful enlargement of the European Union. The social partners play an indispensable role in development, validation, and recognition of vocational competencies and qualifications at all levels and are partners in promotion of…

  13. Desert dust contribution to PM10 loads in Italy: Methods and recommendations addressing the relevant European Commission Guidelines in support to the Air Quality Directive 2008/50

    NASA Astrophysics Data System (ADS)

    Barnaba, Francesca; Bolignano, Andrea; Di Liberto, Luca; Morelli, Matteo; Lucarelli, Franco; Nava, Silvia; Perrino, Cinzia; Canepari, Silvia; Basart, Sara; Costabile, Francesca; Dionisi, Davide; Ciampichetti, Spartaco; Sozzi, Roberto; Gobbi, Gian Paolo

    2017-07-01

    In 2011 the European Commission (EC) released specific 'Guidelines' describing the methods to quantify and subtract the contribution of natural sources from the PM10 values regulated by the European Air Quality Directive (2008/50/EC). This work investigates the applicability to Italy of the EC-Methodology suggested for desert-dust, describes main limitations encountered and proposes specific modifications embedded within a 'revised-Methodology' to extend/improve its use. The revised-Methodology capabilities are evaluated using original, chemically-resolved mineral-dust mass concentration measurements, showing better performances in predicting timing and absolute values of the desert-dust contribution to the daily-PM10 with respect to the current EC-approach. The revised-Methodology is then translated into an automatic (user-independent) tool tailored to the expected final-users. This tool is applied over Central Italy across a 3-year long period (2012-2014), and over the whole Italian country for a calendar year (2012). The derived results confirm and extend to Italian regions never addressed before some previously observed features of the desert-dust impact over the country, such as a clear latitudinal dependence of the desert-dust impact on the yearly average PM10 (from more than 5 μg/m3 to less than 0.5 μg/m3, going from south to north Italy). The modifications introduced within the revised-Methodology also suggest a non-negligible role of desert-dust resuspension in areas characterized by both high traffic levels and soil sealing (urban areas and along the major Italian routes). In the Rome area, such an effect is found to add a contribution of about 2 μg/m3 (i.e., of 20%) to the mean desert-dust load per dust day (about 10 μg/m3). At the national level, this effect contributes increasing the total number of desert-dust-driven exceedances of the PM10 daily limit value even in the northern regions, where the desert-dust impact on the PM10 yearly average is

  14. Large aperture Fizeau interferometer commissioning and preliminary measurements of a long x-ray mirror at European X-ray Free Electron Laser

    SciTech Connect

    Vannoni, M. Freijo Martín, I.

    2016-05-15

    The European XFEL (X-ray Free Electron Laser) is a large facility under construction in Hamburg, Germany. It will provide a transversally fully coherent x-ray radiation with outstanding characteristics: high repetition rate (up to 2700 pulses with a 0.6 ms long pulse train at 10 Hz), short wavelength (down to 0.05 nm), short pulse (in the femtoseconds scale), and high average brilliance (1.6 ⋅ 10{sup 25} (photons s{sup −1} mm{sup −2} mrad{sup −2})/0.1% bandwidth). The beam has very high pulse energy; therefore, it has to be spread out on a relatively long mirror (about 1 m). Due to the very short wavelength, the mirrors need to have a high quality surface on their entire length, and this is considered very challenging even with the most advanced polishing methods. In order to measure the mirrors and to characterize their interaction with the mechanical mount, we equipped a metrology laboratory with a large aperture Fizeau interferometer. The system is a classical 100 mm diameter commercial Fizeau, with an additional expander providing a 300 mm diameter beam. Despite the commercial nature of the system, special care has been taken in the polishing of the reference flats and in the expander quality. We report the first commissioning of the instrument, its calibration, and performance characterization, together with some preliminary results with the measurement of a 950 mm silicon substrate. The intended application is to characterize the final XFEL mirrors with nanometer accuracy.

  15. "FACILS 2014: Microbially-driven facilitation systems in environmental biotechnology" (hereafter "FACILS") presented here by the European Commission (EC)-United States (US) Task Force on Biotechnology Research

    SciTech Connect

    Methe, Barbara

    2016-02-03

    As we enter the 21st century, the sustainability of the biosphere is a global challenge that can best be met with a global response. This includes how we train and promote our next generation of research scientists in the emerging arenas of genome-enabled biology and a bio-based economy. It is this fundamental issue that formed the motivation for designing and conducting a shortcourse entitled “FACILIS 2014: Microbially-driven facilitation systems in environmental biotechnology” (hereafter “FACILIS”) presented here by the European Commission (EC)-United States (US) Task Force on Biotechnology Research. This WG was established in 1994 under the umbrella of the US-EC Task Force on Biotechnology Research, a transatlantic collaborative group overseen by the US Office of Science and Technology Policy (OSTP) and the EC. The Environmental Biotechnology Working Group maintains several goals, including establishing research links between scientists in EU countries and the US and fostering the careers of junior scientists from both sides of the Atlantic to the global nature of scientific cooperation. To that end, a shortcourse was held at the University of Milan in Italy on July 12-25 2014 organized around cross-cutting themes of genomic science and designed to attract a stellar group of interdisciplinary early carrier researchers. A total of 22 students, 10 from the US and 12 from the EU participated. The course provided them with hands-on experience with the latest scientific methods in genomics and bioinformatics; using a format that combines lectures, laboratory research and field work with the final goal to enable researchers to finally turn data into knowledge.

  16. CASAM: a European R&T project for the protection of commercial aircrafts in flight

    NASA Astrophysics Data System (ADS)

    Tholl, Hans Dieter; Vergnolle, Jean-Francois

    2008-10-01

    CASAM (Civil Aircraft Security Against Manpads) is a Framework Program 6 (FP 6) Project launched by the European Commission, DG Research-Aeronautics, binding together a group of 18 companies and research institutions from majors to SMEs. The global objective of the CASAM Project is to design, build, test and validate on ground a closed-loop laser-based DIRCM (Directed IR Countermeasure) equipment for jamming an infrared guided missile fired against a commercial airliner. The broad expertise of the CASAM team allows to address all technical, financial and legal matters dealing with the challenging topic of protecting civilian aircrafts against MANPADS. This paper reviews the main aspects of the projects.

  17. ACCUMULATION OF M1DG DNA ADDUCTS AFTER ...

    EPA Pesticide Factsheets

    ABSTRACT: Oxidative DNA damage is one of the key events leading to mutation and cancer. The present study examined the accumulation of M1dG DNA adducts, 3-(2’-deoxy-β-D-erythro-pentofuranosyl)-pyrimido[1,2-a]-purin-10(3H)-one, after single or yearly exposure to polyhalogenated aromatic hydrocarbons (PHAH) in order to test the role of oxidative DNA damage in PHAH carcinogenicity. The effect of PHAH exposure on the number of M1dG adducts was explored initially in female mice exposed to a single dose of either TCDD or a PHAH mixture. This study demonstrated that a single exposure to PHAH had no significant effect on the number of M1dG adducts compared to the corn oil control group. The role of M1dG adducts in PCB-induced carcinogenicity was further investigated in rats exposed for a year to PCB 153, PCB 126, or a mixture of the two. PCB 153 had no significant effect on M1dG adducts number in liver and brain tissues from the exposed rats compared to controls. However, high dose PCB 126 exposure resulted in M1dG adducts accumulation in the liver. More importantly, starting at low doses, co-administration of equal proportions of PCB 153 and PCB 126 resulted in dose-dependent increases in M1dG adducts accumulation in the liver. Interestingly, the result from co-administration of different amounts of PCB 153 with fixed amounts of PCB 126 demonstrated more M1dG adducts accumulation with higher doses of PCB 153. These results are consistent with the results from canc

  18. European biofuel plan snagged

    SciTech Connect

    Chynoweth, E.

    1992-12-16

    European Commission proposals for a directive aimed at boosting production of biofuels have been set back by the European Parliament and will not be implemented on the January 1, 1993 deadline. Furthermore, the commission has agreed to carry out an environmental impact study on biofuels. European industrial ethanol, fatty acid, and glycerin producers oppose the directive proposals fearing distortions in their markets.

  19. Beyond Commissioning

    SciTech Connect

    Brambley, Michael R.; Katipamula, Srinivas

    2004-08-31

    The emerging practice of building commissioning generally provides energy savings of 10% to, in some cases, more than 60% of a building's energy consumption. Moreover, commissioning ensures that equipment and systems are installed and operate properly, providing occupants with the conditions expected. Without commissioning, new buildings can have incorrect equipment installed, devices like fans installed backwards, and unimplemented control algorithms to mention a few deficiencies sometimes found. Existing buildings can have faulty and failed equipment such as clogged filters and coils, stuck dampers, leaky valves, and imbalanced air distribution, as well as overridden controls, improper set points, and incorrect schedules. Commissioning of new and existing buildings helps prevent and alleviate such problems. Yet only a small fraction of commercial buildings has ever been commissioned, and many buildings that have been commissioned have only a fraction of the recommended actions implemented. Time may change this situation or maybe other changes can accelerate the progress of commissioning. Will commissioning continue in the future as it is performed today or must it change? The authors share a vision for how the functions provided by commissioning could change in the future. The paper delves into the roles of automation technology for functional testing, diagnostics, prognostics, data management, asset tracking, and project management in building commissioning. Methods of delivery explored for these capabilities include laptop-, desktop-, and pda-based tools, web-based services, and ubiquitous embedded networked processing. The authors present a vision for how these technologies could change the practice of commissioning and the impacts this could bring for commercial buildings in the U.S. and throughout the world. Potential impacts on building performance, energy consumption, peak power, and occupant satisfaction are examined.

  20. ATF2 Commissioning

    SciTech Connect

    Seryi, A.; Christian, G.; Parker, B.; Schulte, D.; Delahaye, J.-P.; Tomas, R.; Zimmermann, F.; Wolski, A.; Elsen, E.; Sanuki, T.; Gianfelice-Wendt, E.; Ross, M.; Wendt, M.; Takahashi, T.; Bai, S.; Gao, J.; Bolzon, B.; Geffroy, N.; Jeremie, A.; Apsimon, R.; Burrows, P.; /Oxford U., JAI /Kyoto U., Inst. Chem. Res. /Kyungpook Natl. U. /Orsay, LAL /Phang Accelerator Lab /Royal Holloway, U. of London /SLAC /Daresbury /University Coll. London /Manchester U. /Univ. of Tokyo U.

    2009-10-30

    ATF2 is a final-focus test beam line that aims to focus the low-emittance beam from the ATF damping ring to a beam size of about 37 nm, and at the same time to demonstrate nm beam stability, using numerous advanced beam diagnostics and feedback tools. The construction has been finished at the end of 2008 and the beam commissioning of ATF2 has started in December of 2008. ATF2 is constructed and commissioned by ATF international collaborations with strong US, Asian and European participation.

  1. Commissioning MMS

    NASA Technical Reports Server (NTRS)

    Wood, Paul; Gramling, Cheryl; Stone, John; Smith, Patrick; Reiter, Jenifer

    2016-01-01

    This paper discusses commissioning of NASAs Magnetospheric MultiScale (MMS) Mission. The mission includes four identical spacecraft with a large, complex set of instrumentation. The planning for and execution of commissioning for this mission is described. The paper concludes by discussing lessons learned.

  2. Classification of skin sensitizing substances: a comparison between approaches used by the DFG-MAK Commission and the European Union legislation.

    PubMed

    Lessmann, H; Uter, W; Diepgen, T L; Drexler, H; Fartasch, M; Greim, H; Hartwig, A; Kreis, P; Löser, E; Merget, R; Merk, H; Nowak, D; Rothe, A; Stropp, G; Schnuch, A

    2011-10-01

    A systematic classification of substances (or mixtures of substances) with regard to various toxicological endpoints is a prerequisite for the implementation of occupational safety strategies. As its principal task the "Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area" of the "Deutsche Forschungsgemeinschaft" (DFG-MAK Commission) derives and recommends maximum workplace concentrations and biological tolerance values (MAK and BAT values) based exclusively on scientific arguments. Several endpoints are evaluated separately in detail, e.g. carcinogenicity, risks during pregnancy, germ cell mutagenicity or contribution to systemic toxicity after cutaneous absorption. Skin- and airway sensitization is also considered; the present paper focuses on these two endpoints.

  3. Joint Commission

    MedlinePlus

    Skip to main content The Joint Commission Log In | Request Guest Access Forgot password? | Log In Help Contact Us | Careers | JCR Web Store | Press Room Search Home Accreditation Accreditation Ambulatory Health ...

  4. The Impact on Education for Librarianship and Information Studies of the Bologna Process and Related European Commission Programmes--and Some Outstanding Issues in Europe and Beyond

    ERIC Educational Resources Information Center

    Johnson, Ian M.

    2013-01-01

    The Bologna Declaration of 1999 is the basis for continuing reforms in higher education intended to support international mobility in employment within the European Union. This paper describes the standardised structure and nomenclature for courses that have been implemented, together with a credit transfer system, a quality assurance regime, and…

  5. The Impact on Education for Librarianship and Information Studies of the Bologna Process and Related European Commission Programmes--and Some Outstanding Issues in Europe and Beyond

    ERIC Educational Resources Information Center

    Johnson, Ian M.

    2013-01-01

    The Bologna Declaration of 1999 is the basis for continuing reforms in higher education intended to support international mobility in employment within the European Union. This paper describes the standardised structure and nomenclature for courses that have been implemented, together with a credit transfer system, a quality assurance regime, and…

  6. 78 FR 65869 - Airworthiness Directives; DG Flugzeugbau GmbH Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ...-17646; AD 2013-22-14] RIN 2120-AA64 Airworthiness Directives; DG Flugzeugbau GmbH Gliders AGENCY... adopting a new airworthiness directive (AD) for any DG Flugzeugbau GmbH Model DG-1000T glider equipped with... information about the technical content of the requirements in this AD, contact Solo Kleinmotoren GmbH...

  7. The challenge of challenge testing to monitor Listeria monocytogenes growth on ready-to-eat foods in Europe by following the European Commission (2014) Technical Guidance document.

    PubMed

    Álvarez-Ordóñez, Avelino; Leong, Dara; Hickey, Bernadette; Beaufort, Annie; Jordan, Kieran

    2015-09-01

    European Regulation (EC) No. 2073/2005 lays down the microbiological criteria for certain microorganisms in foods and the implementing rules to be complied with by food business operators (FBOs) in Europe when implementing general and specific hygiene measures. In relation to Listeria monocytogenes, this regulation covers primarily ready-to-eat (RTE) food products, and requires different microbiological criteria depending on the ability of the food product to support growth of L. monocytogenes. In addition, this regulation establishes that food safety is the responsibility of the FBO. The FBO can conduct studies to evaluate the growth of L. monocytogenes that may be present in the product during the shelf-life under reasonably foreseeable storage conditions of distribution, storage and use in order to investigate compliance with the criteria throughout the shelf-life of the product. The European Union Community Reference Laboratory for L. monocytogenes published a revised technical guidance document in June 2014 for conducting shelf-life studies on L. monocytogenes in RTE foods. This review article describes the recently published European guidance document, with special focus on the design of challenge studies to determine the growth potential of L. monocytogenes on foods. Information is given particularly on what a challenge test is and when one is advisable. The factors to be considered and the laboratory methodology to be applied when performing a challenge test to determine the growth potential of L. monocytogenes in a defined food matrix are also described. Results of recent research articles applying challenge tests to determine the growth of L. monocytogenes in a range of foodstuffs are summarized and discussed. Finally, recommendations for obtaining data that can contribute to any further revision of the guidance document and for addressing the main challenges of challenge testing for FBOs are presented. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Maternal obesity in Europe: where do we stand and how to move forward?: A scientific paper commissioned by the European Board and College of Obstetrics and Gynaecology (EBCOG).

    PubMed

    Devlieger, Roland; Benhalima, Katrien; Damm, Peter; Van Assche, André; Mathieu, Chantal; Mahmood, Tahir; Dunne, Fidelma; Bogaerts, Annick

    2016-06-01

    Paralleling the global epidemic of obesity figures in the general population, the incidence of maternal obesity (BMI>30kg/m(2) at the start of pregnancy) has been rising over the last world. While most European countries do not systematically report obesity figures in their pregnant population, the prevalence of maternal obesity varies from 7 to 25% and seems strongly related to social and educational inequalities. Obesity during pregnancy represents an important preventable risk factor for adverse pregnancy outcomes and is associated with negative long-term health outcomes for both mothers and offspring. These effects are often aggravated by the high incidence of abnormal glucose tolerance and excessive gestational weight gain found in this group. The main controversies around the management of the obese pregnant women are related to (1) the value of repeated weighing during pregnancy, (2) the optimal gestational weight gain to advise and the lifestyle messages to deliver in order to achieve this, (3) the optimal strategy and timing of screening for gestational diabetes (GDM) and (4) the optimal timing and mode of delivery. These controversies are reviewed in this review, with the exception of screening for gestational diabetes that is discussed extensively elsewhere in this issue (Benhalima et al.). An agenda for research is proposed with the hope that it will catch the attention of policy-makers and funders and ultimately lead to the development of European-wide evidence-based guidelines for clinicians.

  9. WATER VAPOR IN THE PROTOPLANETARY DISK OF DG Tau

    SciTech Connect

    Podio, L.; Dougados, C.; Thi, W.-F.; Menard, F.; Pinte, C.; Codella, C.; Cabrit, S.; Nisini, B.; Sandell, G.; Williams, J. P.; Testi, L.; Woitke, P.

    2013-03-20

    Water is key in the evolution of protoplanetary disks and the formation of comets and icy/water planets. While high-excitation water lines originating in the hot inner disk have been detected in several T Tauri stars (TTSs), water vapor from the outer disk, where most water ice reservoirs are stored, was only reported in the nearby TTS TW Hya. We present spectrally resolved Herschel/HIFI observations of the young TTS DG Tau in the ortho- and para-water ground-state transitions at 557 and 1113 GHz. The lines show a narrow double-peaked profile, consistent with an origin in the outer disk, and are {approx}19-26 times brighter than in TW Hya. In contrast, CO and [C II] lines are dominated by emission from the envelope/outflow, which makes H{sub 2}O lines a unique tracer of the disk of DG Tau. Disk modeling with the thermo-chemical code ProDiMo indicates that the strong UV field, due to the young age and strong accretion of DG Tau, irradiates a disk upper layer at 10-90 AU from the star, heating it up to temperatures of 600 K and producing the observed bright water lines. The models suggest a disk mass of 0.015-0.1 M{sub Sun }, consistent with the estimated minimum mass of the solar nebula before planet formation, and a water reservoir of {approx}10{sup 2}-10{sup 3} Earth oceans in vapor and {approx}100 times larger in the form of ice. Hence, this detection supports the scenario of ocean delivery on terrestrial planets by the impact of icy bodies forming in the outer disk.

  10. Dynamic Rupture Benchmarking of the ADER-DG Method

    NASA Astrophysics Data System (ADS)

    Pelties, C.; Gabriel, A.

    2012-12-01

    We will verify the arbitrary high-order derivative Discontinuous Galerkin (ADER-DG) method in various test cases of the 'SCEC/USGS Dynamic Earthquake Rupture Code Verification Exercise' benchmark suite (Harris et al. 2009). The ADER-DG scheme is able to solve the spontaneous rupture problem with high-order accuracy in space and time on three-dimensional unstructured tetrahedral meshes. Strong mesh coarsening or refinement at areas of interest can be applied to keep the computational costs feasible. Moreover, the method does not generate spurious high-frequency contributions in the slip rate spectra and therefore does not require any artificial damping as demonstrated in previous presentations and publications (Pelties et al. 2010 and 2012). We will show that the mentioned features hold also for more advanced setups as e.g. a branching fault system, heterogeneous background stresses and bimaterial faults. The advanced geometrical flexibility combined with an enhanced accuracy will make the ADER-DG method a useful tool to study earthquake dynamics on complex fault systems in realistic rheologies. References: Harris, R.A., M. Barall, R. Archuleta, B. Aagaard, J.-P. Ampuero, H. Bhat, V. Cruz-Atienza, L. Dalguer, P. Dawson, S. Day, B. Duan, E. Dunham, G. Ely, Y. Kaneko, Y. Kase, N. Lapusta, Y. Liu, S. Ma, D. Oglesby, K. Olsen, A. Pitarka, S. Song, and E. Templeton, The SCEC/USGS Dynamic Earthquake Rupture Code Verification Exercise, Seismological Research Letters, vol. 80, no. 1, pages 119-126, 2009 Pelties, C., J. de la Puente, and M. Kaeser, Dynamic Rupture Modeling in Three Dimensions on Unstructured Meshes Using a Discontinuous Galerkin Method, AGU 2010 Fall Meeting, abstract #S21C-2068 Pelties, C., J. de la Puente, J.-P. Ampuero, G. Brietzke, and M. Kaeser, Three-Dimensional Dynamic Rupture Simulation with a High-order Discontinuous Galerkin Method on Unstructured Tetrahedral Meshes, JGR. - Solid Earth, VOL. 117, B02309, 2012

  11. Dynamic Rupture Benchmarking of the ADER-DG Method

    NASA Astrophysics Data System (ADS)

    Gabriel, Alice; Pelties, Christian

    2013-04-01

    We will verify the arbitrary high-order derivative Discontinuous Galerkin (ADER-DG) method in various test cases of the 'SCEC/USGS Dynamic Earthquake Rupture Code Verification Exercise' benchmark suite (Harris et al. 2009). The ADER-DG scheme is able to solve the spontaneous rupture problem with high-order accuracy in space and time on three-dimensional unstructured tetrahedral meshes. Strong mesh coarsening or refinement at areas of interest can be applied to keep the computational costs feasible. Moreover, the method does not generate spurious high-frequency contributions in the slip rate spectra and therefore does not require any artificial damping as demonstrated in previous presentations and publications (Pelties et al. 2010 and 2012). We will show that the mentioned features hold also for more advanced setups as e.g. a branching fault system, heterogeneous background stresses and bimaterial faults. The advanced geometrical flexibility combined with an enhanced accuracy will make the ADER-DG method a useful tool to study earthquake dynamics on complex fault systems in realistic rheologies. References: Harris, R.A., M. Barall, R. Archuleta, B. Aagaard, J.-P. Ampuero, H. Bhat, V. Cruz-Atienza, L. Dalguer, P. Dawson, S. Day, B. Duan, E. Dunham, G. Ely, Y. Kaneko, Y. Kase, N. Lapusta, Y. Liu, S. Ma, D. Oglesby, K. Olsen, A. Pitarka, S. Song, and E. Templeton, The SCEC/USGS Dynamic Earthquake Rupture Code Verification Exercise, Seismological Research Letters, vol. 80, no. 1, pages 119-126, 2009 Pelties, C., J. de la Puente, and M. Kaeser, Dynamic Rupture Modeling in Three Dimensions on Unstructured Meshes Using a Discontinuous Galerkin Method, AGU 2010 Fall Meeting, abstract #S21C-2068 Pelties, C., J. de la Puente, J.-P. Ampuero, G. Brietzke, and M. Kaeser, Three-Dimensional Dynamic Rupture Simulation with a High-order Discontinuous Galerkin Method on Unstructured Tetrahedral Meshes, JGR. - Solid Earth, VOL. 117, B02309, 2012

  12. DG Planning with Amalgamation of Operational and Reliability Considerations

    NASA Astrophysics Data System (ADS)

    Battu, Neelakanteshwar Rao; Abhyankar, A. R.; Senroy, Nilanjan

    2016-04-01

    Distributed Generation has been playing a vital role in dealing issues related to distribution systems. This paper presents an approach which provides policy maker with a set of solutions for DG placement to optimize reliability and real power loss of the system. Optimal location of a Distributed Generator is evaluated based on performance indices derived for reliability index and real power loss. The proposed approach is applied on a 15-bus radial distribution system and a 18-bus radial distribution system with conventional and wind distributed generators individually.

  13. Meeting the European Commission performance criteria for the use of triple quadrupole GC-MS/MS as a confirmatory method for PCDD/Fs and dl-PCBs in food and feed samples.

    PubMed

    Ábalos, Manuela; Cojocariu, Cristian I; Silcock, Paul; Roberts, Dominic; Pemberthy, Diana M; Sauló, Jordi; Abad, Esteban

    2016-05-01

    Until recently, European Union (EU) legislation required the use of high-resolution gas chromatography coupled to high-resolution mass spectrometry (HRGC-HRMS) based on magnetic sector analyzers as a standard approach for confirmatory analysis of dioxins (PCDDs) and furans (PCDFs) in feed and food. However, recent technological advances in MS instruments enabled other alternative analytical techniques to meet the same analytical criteria as those requested for HRGC-HRMS. In this sense, triple quadrupoles (GC-MS/MS) can be a realistic alternative for the analysis of dioxins. In this work, the performance of GC-MS/MS technology was evaluated against the criteria demanded by the EU for confirmatory analysis of dioxins and PCBs in food and feed. Thus, the study comprises a number of parameters including chromatographic separation, limit of quantification, linearity, repeatability, and ion ratio precision. Analyses of solvent standards as well as sample extracts (inter-calibration extracts and certified reference materials) were also considered within the scope of this study. Additionally, direct comparisons of the results obtained by GC-MS/MS with those from GC-HRMS were made. The results of this work suggested that GC-MS/MS was highly sensitive and selective for confirmatory analysis of PCDD/Fs and related compounds in food and feed samples and meets all the criteria requested by the European Commission.

  14. Ham Video Commissioning in Columbus

    NASA Image and Video Library

    2014-04-13

    Documentation of the Ham Video unit installed in the Columbus European Laboratory. Part number (P/N) is HAM-11000-0F, serial number (S/N) is 01, barcode is HAMV0001E. Image was taken during Expedition 39 Ham Video commissioning activities and released by astronaut on Twitter.

  15. Evaluation of modified dichloran 18% glycerol (DG18) agar for enumerating fungi in wheat flour: a collaborative study.

    PubMed

    Beuchat, L R; Hwang, C A

    1996-04-01

    Dichloran 18% glycerol agar base supplemented with 100 micrograms of chloramphenicol ml-1 (DG18 agar) was compared to DG18 agar supplemented with 100 micrograms of Triton X-301 ml-1 (DG18T) and DG18 agar supplemented with 1 microgram of iprodione [3-(3,5-dichlorophenyl)-N-(1-methyl-ethyl)-2,4-dioxo-1-imidazolidine- carboxamide] ml-1 (DG18I agar) for enumeration of fungi in ten brands of wheat flour. As the flours contained low fungal populations, all were inoculated with two to four strains of xerophilic fungi (Aspergillus candidus, A. penicillioides, Eurotium amstelodami, E. intermedium, E. repens, E. rubrum, E. tonophilum, E. umbrosum and Wallemia sebi), after which counts ranged from 3.87 to 6.37 log10 CFU g-1. Significantly higher populations (p < 0.05) were detected in four flours: three were on DG18T compared to DG18 and DG18I agar. A. candidus had been inoculated into all three flours. E. amstelodami, E. intermedium, E. repens or E. tonophilum had also been inoculated into at least one of the three flours showing significantly higher numbers of CFU on DG18T agar. Analysis of collapsed data from all samples showed that DG18T agar was significantly better than DG18 or DG18I agars at p < 0.10 but not at p < 0.05. Coefficients of variation for reproducibility (among-laboratory variation) were 8.4%, 7.5% and 8.6%, respectively, for DG18, DG18T and DG18I agars. DG18I agar restricted colony development most, especially for Eurotium species. Naturally occurring Penicillium species grew equally well on DG18 and DG18T agars, whereas W. sebi grew well on all three media. DG18T agar was judged to be superior to DG18 and DG18I agars for enumerating fungi in wheat flours.

  16. The evaluation of technical models used for major-accident hazard installations. Report to Commission of the European Communities Directorate General 12

    NASA Astrophysics Data System (ADS)

    Britter, R. E.

    1991-08-01

    Models are used in many ways by individuals and organizations within the European Community. Within the context of major technological hazards decisions of considerable importance are based wholly, or partly, on these models. The quality, that is the fitness-for-purpose, of these models will differ and there is obviously an interest in both the relative quality of one model against another and the absolute quality of any particular model. This leads to the evaluation of model quality and to methods by which model quality might be improved. It is noted that models are a principal method for the transfer of technology but also that the nature, role, and limitations of models is frequently misunderstood. There is a widespread demand for guidance on model quality and consequently on the development of evaluation techniques. The CEC is an appropriate body to have a role in the study of the quality and the management of quality of technical models. The evaluation of the quality of technical models entails: (1) an assurance of correct coding of algorithms is required and this is probably straightforward; (2) a statistical model validation is required and this entails comparison with experimental data sets (considerable care is required in performing such a validation, in particular in determination of an appropriate protocol to ensure unambiguous conclusions to be drawn from the validation); and (3) a model assessment including a scientific review and other less objective aspects is also required and should be given equal weight to a statistical model validation. Actions which may lead to an improvement in model quality are presented.

  17. Genomewide identification of target genes of histone methyltransferase dG9a during Drosophila embryogenesis.

    PubMed

    Shimaji, Kouhei; Konishi, Takahiro; Tanaka, Shintaro; Yoshida, Hideki; Kato, Yasuko; Ohkawa, Yasuyuki; Sato, Tetsuya; Suyama, Mikita; Kimura, Hiroshi; Yamaguchi, Masamitsu

    2015-11-01

    Post-translational modification of the histone plays important roles in epigenetic regulation of various biological processes. Among the identified histone methyltransferases (HMTases), G9a is a histone H3 Lys 9 (H3K9)-specific example active in euchromatic regions. Drosophila G9a (dG9a) has been reported to feature H3K9 dimethylation activity in vivo. Here, we show that the time required for hatching of a homozygous dG9a null mutant and heteroallelic combination of dG9a null mutants is delayed, suggesting that dG9a is at least partially responsible for progression of embryogenesis. Immunocytochemical analyses of the wild-type and the dG9a null mutant flies indicated that dG9a localizes in cytoplasm up to nuclear division cycle 7 where it is likely responsible for di-methylation of nucleosome-free H3K9. From cycles 8-11, dG9a moves into the nucleus and is responsible for di-methylating H3K9 in nucleosomes. RNA-sequence analysis utilizing early wild-type and dG9a mutant embryos showed that dG9a down-regulates expression of genes responsible for embryogenesis. RNA fluorescent in situ hybridization analysis further showed temporal and spatial expression patterns of these mRNAs did not significantly change in the dG9a mutant. These results indicate that dG9a controls transcription levels of some zygotic genes without changing temporal and spatial expression patterns of the transcripts of these genes.

  18. The role of competitive learning in the generation of DG fields from EC inputs.

    PubMed

    Si, Bailu; Treves, Alessandro

    2009-06-01

    We follow up on a suggestion by Rolls and co-workers, that the effects of competitive learning should be assessed on the shape and number of spatial fields that dentate gyrus (DG) granule cells may form when receiving input from medial entorhinal cortex (mEC) grid units. We consider a simple non-dynamical model where DG units are described by a threshold-linear transfer function, and receive feedforward inputs from 1,000 mEC model grid units of various spacing, orientation and spatial phase. Feedforward weights are updated according to a Hebbian rule as the virtual rodent follows a long simulated trajectory through a single environment. Dentate activity is constrained to be very sparse. We find that indeed competitive Hebbian learning tends to result in a few active DG units with a single place field each, rounded in shape and made larger by iterative weight changes. These effects are more pronounced when produced with thousands of DG units and inputs per DG unit, which the realistic system has available, than with fewer units and inputs, in which case several DG units persists with multiple fields. The emergence of single-field units with learning is in contrast, however, to recent data indicating that most active DG units do have multiple fields. We show how multiple irregularly arranged fields can be produced by the addition of non-space selective lateral entorhinal cortex (lEC) units, which are modelled as simply providing an additional effective input specific to each DG unit. The mean number of such multiple DG fields is enhanced, in particular, when lEC and mEC inputs have overall similar variance across DG units. Finally, we show that in a restricted environment the mean size of the fields is unaltered, while their mean number is scaled down with the area of the environment.

  19. Radioactive 2-DG incorporation patterns in the mesial frontal cortex of task-performing monkeys.

    PubMed

    Matsunami, K; Kawashima, T

    1995-11-01

    The pattern of radioactive 2-deoxy-D-glucose (2-DG) uptake in the rostral mesial cortex was investigated in seven hemispheres of four task-performing monkeys (a delayed-response task performed with a forelimb). A two-dimensional 2-DG map was constructed from frontal sections. Blob-like 2-DG incorporation sites (2-DG active sites) were observed in single frontal sections, e.g., in the anterior cingulate gyrus (CiG) and supplementary and primary motor cortices in the mesial surface, and around the superior precentral sulcus in the premotor area. Blob-like 2-DG incorporation sites were also observed in the medial part of the dorsal frontal cortex near the midline. However, most of these blob-like 2-DG active sites were revealed in fact not to be blobs. They formed rostrocaudally continuous streaks when they were constructed in a two-dimensional map. Streaks fused with one another in some areas, and gave off branches in other areas. These 2-DG uptake patterns were similar between the paired left and right hemispheres of three brains. It is highly probable that these 2-DG active streaks (or blobs) reflected neuronal activity related to somatomotor and/or eye movements, because the 2-DG-labeled areas included motor, premotor, supplementary motor, and possibly part of the supplementary eye fields. It is also probable that this 2-DG incorporation was related to cognitive or memory functions, because neuronal activity related to performance of a delayed-response was reported in the rostral mesial cortex and in the CiG.

  20. Coronal Emission from dG Halo Stars

    NASA Technical Reports Server (NTRS)

    Mushotzky, Richard (Technical Monitor); Harnden, F. R.

    2005-01-01

    The halo dG star HD 114762 was observed with the XMM-Newton satellite on 28-29 June 2004, during orbit 834, and the data were processed using the XMM-Newton Science Analysis System (SAS), version 6.0.0. Somewhat surprisingly, the target was NOT detected during this approx.30 ks exposure, which yielded instead a count rate upper limit of less than 0.0041 cts/s. We computed an X-ray flux upper limit by assuming a Raymond-Smith thermal spectrum of coronal temperature 1 million degrees K, typical of quiet old stars, a hydrogen column density of 2-10$^{19)$ cm$^{-2)$ and sub-solar abundances of 0.2. Our calculated X-ray luminosity upper limit in the 0.25-7.8 keV band is L$_x < 4.95 $\\time$10$^{26)$ erg/s, where we have assumed a stellar distance of 28 pc. This relatively low upper limit has implications for the capability of metal poor stars to host solar-like dynamos, as we will report in a forthcoming paper (now in preparation).

  1. Coronal Emission from dG Halo Stars

    NASA Technical Reports Server (NTRS)

    Mushotzky, Richard (Technical Monitor); Harnden, F. R.

    2005-01-01

    The halo dG star HD 114762 was observed with the XMM-Newton satellite on 28-29 June 2004, during orbit 834, and the data were processed using the XMM-Newton Science Analysis System (SAS), version 6.0.0. Somewhat surprisingly, the target was NOT detected during this approx.30 ks exposure, which yielded instead a count rate upper limit of less than 0.0041 cts/s. We computed an X-ray flux upper limit by assuming a Raymond-Smith thermal spectrum of coronal temperature 1 million degrees K, typical of quiet old stars, a hydrogen column density of 2-10$^{19)$ cm$^{-2)$ and sub-solar abundances of 0.2. Our calculated X-ray luminosity upper limit in the 0.25-7.8 keV band is L$_x < 4.95 $\\time$10$^{26)$ erg/s, where we have assumed a stellar distance of 28 pc. This relatively low upper limit has implications for the capability of metal poor stars to host solar-like dynamos, as we will report in a forthcoming paper (now in preparation).

  2. [open quotes]Power for World[close quote]: European proposal for a global photovoltaic action plan

    SciTech Connect

    Not Available

    1994-06-01

    A global action to supply electricity to the more than 1 billion people without electricity today has been proposed by Wolfgang Palz of DG XVII of the Commission of the European Communities, and initial studies are now under way. In this proposal, the key value to Europe and other donor nations is the benefit that would be achieved from the industrialization of solar cell production and the scale effect for PV applications in Europe. At the same time the many benefits to developing countries include the improvement of living conditions in rural areas and the reduction of migration to the cities. Of global value is the environmental benefits of this action. This article describes the strategy and implementation of the program.

  3. 2DG suppresses the in vivo anti-tumor efficacy of erlotinib in HNSCC cells

    PubMed Central

    Sobhakumari, Arya; Orcutt, Kevin; Love-Homan, Laurie; Kowalski, Christopher; Parsons, Arlene; Knudson, C. Michael; Simons, Andrean L.

    2017-01-01

    Poor tumor response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is a significant challenge for effective treatment of head and neck squamous cell carcinoma (HNSCC). Therefore, strategies that may increase tumor response to EGFR TKIs are warranted in order to improve HNSCC patient treatment and overall survival. HNSCC tumors are highly glycolytic and increased EGFR signaling has been found to promote glucose metabolism through various mechanisms. We have previously shown that inhibition of glycolysis with 2-deoxy-D-glucose (2DG) significantly enhanced the antitumor effects of cisplatin and radiation which are commonly used to treat HNSCC. The goal of the current studies is to determine if 2DG will enhance the anti-tumor activity of the EGFR TKI erlotinib in HNSCC. Erlotinib transiently suppressed glucose consumption accompanied by alterations in pyruvate kinase M2 (PKM2) expression. 2DG enhanced the cytotoxic effect of erlotinib in vitro but reversed the anti-tumor effect of erlotinib in vivo. 2DG altered the N-glycosylation status of EGFR and induced the endoplasmic reticulum (ER) stress markers CHOP and BiP in vitro. Additionally, the effects of 2DG+erlotinib on cytotoxicity and ER stress in vitro were reversed by mannose but not glucose or antioxidant enzymes. Lastly, the protective effect of 2DG on erlotinib-induced cytotoxicity in vivo was reversed by chloroquine. Altogether, 2DG suppressed the anti-tumor efficacy of erlotinib in a HNSCC xenograft mouse model which may be due to increased cytoprotective autophagy mediated by ER stress activation. PMID:27178822

  4. Micronutrient recommendation stakeholders' beliefs on dietary guidelines: a qualitative study across six European countries/regions.

    PubMed

    Brown, K A; Timotijevic, L; Barnett, J; Ruprich, J; Řehůřková, I; Hermoso, M; Andersen, L-F; Lillegaard, I T L; Fernández-Celemín, L; Larrañaga, A; Lončarevič-Srmič, A; Raats, M M

    2011-07-01

    A range of stakeholders have been involved in the development and implementation of dietary guidelines (DG) across Europe. Seventy-seven semi-structured qualitative interviews explored stakeholders' beliefs of DG in six European countries/regions. A main theme, variation in the interpretation of the term dietary guideline, was identified using thematic analysis. Descriptions of DG varied across stakeholder groups and countries. Reference was made to both food-based and nutrient-based guidelines, including the terms food-based DG and food guides (for example, pyramids), nutrient recommendations, dietary recommendations, dietary reference values and guideline daily amounts. The terminology surrounding DG requires greater clarity. Until that time, stakeholders would benefit from increased awareness of potential misinterpretations and the implications of this on multi-stakeholder, multi-national policy development and implementation.

  5. [Biobanks European infrastructure].

    PubMed

    Kinkorová, Judita; Topolčan, Ondřej

    2016-01-01

    Biobanks are structured repositories of human tissue samples connected with specific information. They became an integral part of personalized medicine in the new millennium. At the European research area biobanks are isolated not well coordinated and connected to the network. European commission supports European infrastructure BBMRI-ERIC (Biobanks and Biomolecular Resources Research Infrastructure European Research Infrastructure Consortium), consortium of 54 members with more than 225 associated organizations, largely biobanks from over 30 countries. The aim is to support biomedical research using stored samples. Czech Republic is a member of the consortium as a national node BBMRI_CZ, consisting of five partners.

  6. Toward a self-wired active reconstruction of the hippocampal trisynaptic loop: DG-CA3

    PubMed Central

    Brewer, Gregory J.; Boehler, Michael D.; Leondopulos, Stathis; Pan, Liangbin; Alagapan, Sankaraleengam; DeMarse, Thomas B.; Wheeler, Bruce C.

    2013-01-01

    The mammalian hippocampus functions to encode and retrieve memories by transiently changing synaptic strengths, yet encoding in individual subregions for transmission between regions remains poorly understood. Toward the goal of better understanding the coding in the trisynaptic pathway from the dentate gyrus (DG) to the CA3 and CA1, we report a novel microfabricated device that divides a micro-electrode array into two compartments of separate hippocampal network subregions connected by axons that grow through 3 × 10 × 400 μm tunnels. Gene expression by qPCR demonstrated selective enrichment of separate DG, CA3, and CA1 subregions. Reconnection of DG to CA3 altered burst dynamics associated with marked enrichment of GAD67 in DG and GFAP in CA3. Surprisingly, DG axon spike propagation was preferentially unidirectional to the CA3 region at 0.5 m/s with little reverse transmission. Therefore, select hippocampal subregions intrinsically self-wire in anatomically appropriate patterns and maintain their distinct subregion phenotype without external inputs. PMID:24155693

  7. Toward a self-wired active reconstruction of the hippocampal trisynaptic loop: DG-CA3.

    PubMed

    Brewer, Gregory J; Boehler, Michael D; Leondopulos, Stathis; Pan, Liangbin; Alagapan, Sankaraleengam; DeMarse, Thomas B; Wheeler, Bruce C

    2013-01-01

    The mammalian hippocampus functions to encode and retrieve memories by transiently changing synaptic strengths, yet encoding in individual subregions for transmission between regions remains poorly understood. Toward the goal of better understanding the coding in the trisynaptic pathway from the dentate gyrus (DG) to the CA3 and CA1, we report a novel microfabricated device that divides a micro-electrode array into two compartments of separate hippocampal network subregions connected by axons that grow through 3 × 10 × 400 μm tunnels. Gene expression by qPCR demonstrated selective enrichment of separate DG, CA3, and CA1 subregions. Reconnection of DG to CA3 altered burst dynamics associated with marked enrichment of GAD67 in DG and GFAP in CA3. Surprisingly, DG axon spike propagation was preferentially unidirectional to the CA3 region at 0.5 m/s with little reverse transmission. Therefore, select hippocampal subregions intrinsically self-wire in anatomically appropriate patterns and maintain their distinct subregion phenotype without external inputs.

  8. A New Discontinuous Galerkin Method for Convection-Diffusion Problems: The Gradient-Recovery DG Method

    NASA Astrophysics Data System (ADS)

    Johnson, Philip; Johnsen, Eric

    2016-11-01

    The Discontinuous Galerkin (DG) numerical method, while well-suited for hyperbolic PDE systems such as the Euler equations, is not naturally competitive for convection-diffusion systems, such as the Navier-Stokes equations. Where the DG weak form of the Euler equations depends only on the field variables for calculation of numerical fluxes, the traditional form of the Navier-Stokes equations requires calculation of the gradients of field variables for flux calculations. It is this latter task for which the standard DG discretization is ill-suited, and several approaches have been proposed to treat the issue. The most popular strategy for handling diffusion is the "mixed" approach, where the solution gradient is constructed from the primal as an auxiliary. We designed a new mixed approach, called Gradient-Recovery DG; it uses the Recovery concept of Van Leer & Nomura with the mixed approach to produce a scheme with excellent stability, high accuracy, and unambiguous implementation when compared to typical mixed approach concepts. In addition to describing the scheme, we will perform analysis with comparison to other DG approaches for diffusion. Gas dynamics examples will be presented to demonstrate the scheme's capabilities.

  9. Commission 28: Galaxies

    NASA Astrophysics Data System (ADS)

    Sadler, Elaine M.; Combes, Françoise; Okamura, Sadanori; Binney, James J.; Fairall, Anthony P.; Heckman, Timothy M.; Lilly, Simon J.; Karachentseva, Valentina; Kraan-Korteweg, Renée C.; Knapp, Gillian R.; Leibundgut, Bruno; Narlikar, Jayant V.

    2007-12-01

    The members of Commission 28 on Galaxies were very busy during this General Assembly, with the Commission involved in two Symposia (IAU Symposium No. 235 Galaxy Evolution across the Hubble Time, IAU Symposium No. 238 Black Holes: from Stars to Galaxies), and two Joint Discussions (JD07 The Universe at z > 6, JD15 New Cosmology Results from the Spitzer Space Telescope). Therefore, the Business Meeting was combined with the Division VIII Business Meeting, which included a short information session on the new Commission 28 Organizing Committee. The triennial report of the Commission for 2003-2005 was also distributed, and is available on the Commission 28 web site.

  10. Commissioning HVAC systems

    SciTech Connect

    Schiess, K.

    1995-12-01

    In recent years, commissioning has been viewed as a separate process that had to be specified and implemented by a specialized entity. This article discusses commissioning in the HVAC field and looks at it from an international perspective. The author has worked in Europe, South Africa (British system) and the USA. The differences between the British and the American methods of commissioning are discussed, with examples given where the American way was unsuccessful. It is the design engineer`s job to test and accept (commission) an installation after the contractor has demonstrated the performance to the satisfaction of the design engineer. Once the plant is commissioned, it is put into service.

  11. [Effects of intergenic interaction of the high pigmentation gene hp-2(dg) (high pigment-2 dark green) with the gene B (beta-carotene) in tomato].

    PubMed

    Kuzemenskiĭ, A V

    2008-01-01

    It was shown that during intergenic interaction of genes hp-2(dg) and B in dihomozygote an additive factor is formed activating biogenesis of beta-carotene in tomato fruits. In the genotype B/B//hp-2(dg)/hp-2(dg) there is preserved the positive effects of the gene hp-2(dg) on the content of ascorbic acid and the negative one on the content of titrated acids. With this stabilization of the gene hp-2(dg) genetic depression is observed, which is manifested in the increased productivity of B/B//hp-2(dg)/hp-2(dg)-genotypes.

  12. Impacts on the Voltage Profile of DC Distribution Network with DG Access

    NASA Astrophysics Data System (ADS)

    Tu, J. J.; Yin, Z. D.

    2017-07-01

    With the development of electronic, more and more distributed generations (DGs) access into grid and cause the research fever of direct current (DC) distribution network. Considering distributed generation (DG) location and capacity have great impacts on voltage profile, so use IEEE9 and IEEE33 typical circuit as examples, with DGs access in centralized and decentralized mode, to compare voltage profile in alternating and direct current (AC/DC) distribution network. Introducing the voltage change ratio as an evaluation index, so gets the general results on voltage profile of DC distributed network with DG access. Simulation shows that, in the premise of reasonable location and capacity, DC distribution network is more suitable for DG access.

  13. Accurate treatment of interface roughness in nanoscale DG MOSFETs using non-equilibrium Green's functions

    NASA Astrophysics Data System (ADS)

    Fonseca, James; Kaya, Savas

    2004-11-01

    In the sub-50-nm scale, the aggressive scaling of MOSFETs is expected to culminate in dual-gate (DG) architectures on SOI substrates. DG MOSFETs are widely accepted to be the ultimate design that silicon can deliver in terms of on and off currents. So far, the design efforts on these novel structures have concentrated on ideal geometries and doping profiles. However, at nanometer scale, devices fabricated with lithography and etching techniques cannot deliver perfect reproductions of the ideal design and suffer significantly from fluctuation effects associated with random doping and interfaces. While the former is less important in undoped, thin-body architecture, the interface roughness is a crucial factor in DG MOSFET performance, as indicated by the International Technology Roadmap for Semiconductors.

  14. Early optical follow-up of the nearby active star DG CVn during its 2014 superflare

    NASA Astrophysics Data System (ADS)

    Caballero-García, M. D.; Šimon, V.; Jelínek, M.; Castro-Tirado, A. J.; Cwiek, A.; Claret, A.; Opiela, R.; Żarnecki, A. F.; Gorosabel, J.; Oates, S. R.; Cunniffe, R.; Jeong, S.; Hudec, R.; Sokolov, V. V.; Makarov, D. I.; Tello, J. C.; Lara-Gil, O.; Kubánek, P.; Guziy, S.; Bai, J.; Fan, Y.; Wang, C.; Park, I. H.

    2015-10-01

    DG Canum Venaticorum (DG CVn) is a binary system in which one of the components is an M-type dwarf ultrafast rotator, only three of which are known in the solar neighbourhood. Observations of DG CVn by the Swift satellite and several ground-based observatories during its superflare event on 2014 allowed us to perform a complete hard X-ray-optical follow-up of a superflare from the red-dwarf star. The observations support the fact that the superflare can be explained by the presence of (a) large active region(s) on the surface of the star. Such activity is similar to the most extreme solar flaring events. This points towards a plausible extrapolation between the behaviour from the most active red-dwarf stars and the processes occurring in the Sun.

  15. Active and Reactive Power Optimal Dispatch Associated with Load and DG Uncertainties in Active Distribution Network

    NASA Astrophysics Data System (ADS)

    Gao, F.; Song, X. H.; Zhang, Y.; Li, J. F.; Zhao, S. S.; Ma, W. Q.; Jia, Z. Y.

    2017-05-01

    In order to reduce the adverse effects of uncertainty on optimal dispatch in active distribution network, an optimal dispatch model based on chance-constrained programming is proposed in this paper. In this model, the active and reactive power of DG can be dispatched at the aim of reducing the operating cost. The effect of operation strategy on the cost can be reflected in the objective which contains the cost of network loss, DG curtailment, DG reactive power ancillary service, and power quality compensation. At the same time, the probabilistic constraints can reflect the operation risk degree. Then the optimal dispatch model is simplified as a series of single stage model which can avoid large variable dimension and improve the convergence speed. And the single stage model is solved using a combination of particle swarm optimization (PSO) and point estimate method (PEM). Finally, the proposed optimal dispatch model and method is verified by the IEEE33 test system.

  16. DG-FDF solver for large eddy simulation of compressible flows

    NASA Astrophysics Data System (ADS)

    Sammak, Shervin; Brazell, Michael; Mavriplis, Dimitri; Givi, Peyman

    2016-11-01

    A new computational scheme is developed for large eddy simulation (LES) of compressible turbulent flows with the filtered density function (FDF) subgrid scale closure. This is a hybrid scheme, combining the discontinuous Galerkin (DG) Eulerian solver with a Lagrangian Monte Carlo FDF simulator. The methodology is shown to be suitable for LES, as a larger portion of the resolved energy is captured as the order of spectral approximation increases. Simulations are conducted of both subsonic and supersonic flows. The consistency and the overall performance of the DG-FDF solver are demonstrated, together with its shock capturing capabilities.

  17. A robust SN-DG-approximation for radiation transport in optically thick and diffusive regimes

    NASA Astrophysics Data System (ADS)

    Ragusa, J. C.; Guermond, J.-L.; Kanschat, G.

    2012-02-01

    We introduce a new discontinuous Galerkin (DG) method with reduced upwind stabilization for the linear Boltzmann equation applied to particle transport. The asymptotic analysis demonstrates that the new formulation does not suffer from the limitations of standard upwind methods in the thick diffusive regime; in particular, the new method yields the correct diffusion limit for any approximation order, including piecewise constant discontinuous finite elements. Numerical tests on well-established benchmark problems demonstrate the superiority of the new method. The improvement is particularly significant when employing piecewise constant DG approximation for which standard upwinding is known to perform poorly in the thick diffusion limit.

  18. Guidelines for residential commissioning

    SciTech Connect

    Wray, Craig P.; Walker, Iain S.; Sherman, Max H.

    2003-01-31

    Currently, houses do not perform optimally or even as many codes and forecasts predict, largely because they are field assembled and there is no consistent process to identify problems or to correct them. Residential commissioning is a solution to this problem. This guide is the culmination of a 30-month project that began in September 1999. The ultimate objective of the project is to increase the number of houses that undergo commissioning, which will improve the quality, comfort, and safety of homes for California citizens. The project goal is to lay the groundwork for a residential commissioning industry in California focused on end-use energy and non-energy issues. As such, we intend this guide to be a beginning and not an end. Our intent is that the guide will lead to the programmatic integration of commissioning with other building industry processes, which in turn will provide more value to a single site visit for people such as home energy auditors and raters, home inspectors, and building performance contractors. Project work to support the development of this guide includes: a literature review and annotated bibliography, which facilitates access to 469 documents related to residential commissioning published over the past 20 years (Wray et al. 2000), an analysis of the potential benefits one can realistically expect from commissioning new and existing California houses (Matson et al. 2002), and an assessment of 107 diagnostic tools for evaluating residential commissioning metrics (Wray et al. 2002). In this guide, we describe the issues that non-experts should consider in developing a commissioning program to achieve the benefits we have identified. We do this by providing specific recommendations about: how to structure the commissioning process, which diagnostics to use, and how to use them to commission new and existing houses. Using examples, we also demonstrate the potential benefits of applying the recommended whole-house commissioning approach to

  19. Benchmarking in European Higher Education: A Step beyond Current Quality Models

    ERIC Educational Resources Information Center

    Burquel, Nadine; van Vught, Frans

    2010-01-01

    This paper presents the findings of a two-year EU-funded project (DG Education and Culture) "Benchmarking in European Higher Education", carried out from 2006 to 2008 by a consortium led by the European Centre for Strategic Management of Universities (ESMU), with the Centre for Higher Education Development, UNESCO-CEPES, and the…

  20. Benchmarking in European Higher Education: A Step beyond Current Quality Models

    ERIC Educational Resources Information Center

    Burquel, Nadine; van Vught, Frans

    2010-01-01

    This paper presents the findings of a two-year EU-funded project (DG Education and Culture) "Benchmarking in European Higher Education", carried out from 2006 to 2008 by a consortium led by the European Centre for Strategic Management of Universities (ESMU), with the Centre for Higher Education Development, UNESCO-CEPES, and the…

  1. e-Learning--Designing Tomorrow's Education. Communication from the Commission.

    ERIC Educational Resources Information Center

    Commission of the European Communities, Brussels (Belgium).

    At the Lisbon European Council held on March 23 and 24, 2000, a goal was set for the European Union "to become the most competitive and dynamic knowledge-driven economy in the world, capable of sustainable economic growth with more and better jobs and greater social cohesion." The eLearning initiative proposed by the Commission of the…

  2. Hypercohones D-G, New Polycyclic Polyprenylated Acylphloroglucinol Type Natural Products from Hypericum cohaerens.

    PubMed

    Zhang, Jing-Jing; Yang, Xing-Wei; Ma, Jun-Zeng; Liu, Xia; Yang, Li-Xin; Yang, Sheng-Chao; Xu, Gang

    2014-04-01

    Four new polycyclic polyprenylated acylphloroglucinol type metabolites, hypercohones D-G (1-4), along with four known analogues (5-8), were isolated from the aerial parts of Hypericum cohaerens. The structures of these isolates were elucidated by extensive spectroscopic methods. The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.

  3. 77 FR 71359 - Airworthiness Directives; DG Flugzeugbau GmbH Gliders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... aviation product. The MCAI describes the unsafe condition as a material defect within the propeller shaft... Federal Aviation Administration 14 CFR Part 39 RIN 2120-AA64 Airworthiness Directives; DG Flugzeugbau GmbH Gliders AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Notice...

  4. Design optimization of a fuzzy distributed generation (DG) system with multiple renewable energy sources

    NASA Astrophysics Data System (ADS)

    Ganesan, T.; Elamvazuthi, I.; Shaari, Ku Zilati Ku; Vasant, P.

    2012-09-01

    The global rise in energy demands brings major obstacles to many energy organizations in providing adequate energy supply. Hence, many techniques to generate cost effective, reliable and environmentally friendly alternative energy source are being explored. One such method is the integration of photovoltaic cells, wind turbine generators and fuel-based generators, included with storage batteries. This sort of power systems are known as distributed generation (DG) power system. However, the application of DG power systems raise certain issues such as cost effectiveness, environmental impact and reliability. The modelling as well as the optimization of this DG power system was successfully performed in the previous work using Particle Swarm Optimization (PSO). The central idea of that work was to minimize cost, minimize emissions and maximize reliability (multi-objective (MO) setting) with respect to the power balance and design requirements. In this work, we introduce a fuzzy model that takes into account the uncertain nature of certain variables in the DG system which are dependent on the weather conditions (such as; the insolation and wind speed profiles). The MO optimization in a fuzzy environment was performed by applying the Hopfield Recurrent Neural Network (HNN). Analysis on the optimized results was then carried out.

  5. CosmosDG: An hp-adaptive Discontinuous Galerkin Code for Hyper-resolved Relativistic MHD

    NASA Astrophysics Data System (ADS)

    Anninos, Peter; Bryant, Colton; Fragile, P. Chris; Holgado, A. Miguel; Lau, Cheuk; Nemergut, Daniel

    2017-08-01

    We have extended Cosmos++, a multidimensional unstructured adaptive mesh code for solving the covariant Newtonian and general relativistic radiation magnetohydrodynamic (MHD) equations, to accommodate both discrete finite volume and arbitrarily high-order finite element structures. The new finite element implementation, called CosmosDG, is based on a discontinuous Galerkin (DG) formulation, using both entropy-based artificial viscosity and slope limiting procedures for the regularization of shocks. High-order multistage forward Euler and strong-stability preserving Runge-Kutta time integration options complement high-order spatial discretization. We have also added flexibility in the code infrastructure allowing for both adaptive mesh and adaptive basis order refinement to be performed separately or simultaneously in a local (cell-by-cell) manner. We discuss in this report the DG formulation and present tests demonstrating the robustness, accuracy, and convergence of our numerical methods applied to special and general relativistic MHD, although we note that an equivalent capability currently also exists in CosmosDG for Newtonian systems.

  6. 18F-DG PET/CT in detection of recurrence and metastasis of colorectal cancer

    PubMed Central

    Chen, Long-Bang; Tong, Jin-Long; Song, Hai-Zhu; Zhu, Hong; Wang, Yu-Cai

    2007-01-01

    AIM: To evaluate the value of 18F-DG PET/CT in detecting recurrence and/or metastasis of colorectal cancer (CRC). METHODS: Combined visual analysis with semiquantitative analysis, the 18F-DG PET/CT whole-body imaging results and the corresponding clinical data of 68 postoperative CRC patients including 48 male and 20 female with average age of 58.1 were analyzed retrospectively. RESULTS: Recurrence and/or metastasis were confirmed in 56 patients in the clinical follow-up after the PET/CT imaging. The sensitivity of PET/CT diagnosis of CRC recurrence and/or metastasis was 94.6%, and the specificity was 83.3%. The positive predictive value (PPV) was 96.4% and the negative predictive value (NPV) was 76.9%. PET/CT imaging detected one or more occult malignant lesions in 8 cases where abdominal/pelvic CT and/or ultrasonography showed negative findings, and also detected more lesions than CT or ultrasonography did in 30.4% (17/56) cases. Recurrence and/or metastasis was detected in 91.7% (22/24) cases with elevated serum CEA levels by 18F-DG PET/CT imaging. CONCLUSION: 18F-DG PET/CT could detect the recurrence and/or metastasis of CRC with high sensitivity and specificity. PMID:17854148

  7. Long-term Optical Activity of the Hard X-ray Flaring Star DG CVn

    NASA Astrophysics Data System (ADS)

    Šimon, V.

    2017-04-01

    DG CVn is a young late-type star which displayed an X-ray and optical superflare in 2014. This paper presents an analysis of the long-term activity of this object in the optical band. I used the photographic data from DASCH (Digital Access to a Sky Century @ Harvard). These measurements from the years 1895-1989 cover the blue spectral region. CCD V-band ASAS data were used for several UV Cet-type stars to place the activity of DG CVn in the context of flaring stars. I show that three large brightenings (flares) of DG CVn by more than 1 mag were detected on the DASCH plates. The character of the long-term activity (regarding the histogram of brightness) of DG CVn is compatible with those of flaring stars UV Cet and V371 Ori. The flares brighter than ˜ 0.4 mag represent less than 1 percent of the observed data in all three objects

  8. THE COLLEGE COMMISSIONS.

    ERIC Educational Resources Information Center

    FOOKS, JOYCE LANE

    THE HISTORIES, ORGANIZATIONAL STRUCTURES, MODES OF OPERATION, GOALS, AND SPECIFIC ACTIVITIES OF EIGHT COLLEGE SCIENCE COMMISSIONS ARE PRESENTED. THE GOAL OF THE EIGHT COLLEGE SCIENCE COMMISSIONS IS TO BRING UNDERGRADUATE SCIENCE INSTRUCTION CLOSER TO THE RESEARCH FRONTIER, UPDATE COURSES, AND FOSTER THE SPIRIT OF INQUIRY. INTERCOMMISSION…

  9. The Building Commissioning Handbook.

    ERIC Educational Resources Information Center

    Heinz, John A.; Casault, Rick

    This book discusses building commissioning, which is the process of certifying that a new facility meets the required specifications. As buildings have become more complex, the traditional methods for building start-up and final acceptance have been proven inadequate, and building commissioning has been developed, which often necessitates the use…

  10. Get into Commission

    ERIC Educational Resources Information Center

    Limback, Derek

    2012-01-01

    Teachers may be apprehensive about commissioning, and frequently directors do not see it as realistic for their programs. It took the author a while to commission a piece, even though he is often on the composer side. The author asserts that there's already plenty of high-quality literature out there to keep teachers busy, but a bigger factor is…

  11. Commissioning of HVAC systems

    SciTech Connect

    Schiess, K.

    1995-06-01

    In recent years various presentation and discussions have taken place which looked at commissioning as a separate process that had to be specified and implemented by a specialized entity in a project. This presentation discusses commissioning in the HVAC field and looks at it from an international perspective. The author has worked in Europe, South Africa (British system) and in the USA. The differences are discussed between the British and the American methods with some examples where the American way of commissioning was unsuccessful. The conclusion is that it is the design engineer`s job to test and accept (commission) an installation after the contractor has demonstrated the performance to the satisfaction of the design engineer. Once the plant is commissioned, it is put into service.

  12. Putting Dreyfus into Action: The European Credit Transfer System

    ERIC Educational Resources Information Center

    Markowitsch, Jorg; Luomi-Messerer, Karin; Becker, Matthias; Spottl, Georg

    2008-01-01

    Purpose: The purpose of this article is to look closely at the development of a European Credit Transfer System for Vocational Education and Training (ECVET). The European Commission, together with the member States, are working on it and several pilot projects have been initiated within the Leonardo da Vinci Programme of the European Commission.…

  13. Putting Dreyfus into Action: The European Credit Transfer System

    ERIC Educational Resources Information Center

    Markowitsch, Jorg; Luomi-Messerer, Karin; Becker, Matthias; Spottl, Georg

    2008-01-01

    Purpose: The purpose of this article is to look closely at the development of a European Credit Transfer System for Vocational Education and Training (ECVET). The European Commission, together with the member States, are working on it and several pilot projects have been initiated within the Leonardo da Vinci Programme of the European Commission.…

  14. Overexpression of two chrysanthemum DgDREB1 group genes causing delayed flowering or dwarfism in Arabidopsis.

    PubMed

    Tong, Zheng; Hong, Bo; Yang, Yingjie; Li, Qiuhua; Ma, Nan; Ma, Chao; Gao, Junping

    2009-09-01

    We isolated 13 DREB1 (dehydration responsive element binding factor 1) genes from chrysanthemum and further divided them into three groups, DgDREB1A, DgDREB1B and DgDREB1C, based on the phylogenetic analysis. Each group showed their unique expression patterns under cold, dehydration and salt stress conditions. Arabidopsis plants overexpressing DgDREB1A (1A plants) exhibited significantly stronger tolerance to freezing and drought than those overexpressing DgDREB1B (1B plants) and the control plants. In addition, 1A plants showed delayed flowering, but not dwarfism; while 1B plants showed dwarfism, but not delayed flowering. In 1A plants, the expression of three stress-related DREB1-downstream genes, COR47, COR15A, and RD29A, was strongly induced while the expression of CO and FT, two photoperiod responsive flowering-time genes, was inhibited. In 1B plants, the expression of GA2ox7, a GA-deactivation enzyme gene, was dramatically enhanced. The results above strongly suggest that members from different DgDREB1 groups may have distinct effects on plant development: DgDREB1A may be involved in photoperiod-related flowering-time determination and DgDREB1B in GA-mediated plant development.

  15. Disconnection Analysis of CA3 and DG in Mediating Encoding but Not Retrieval in a Spatial Maze Learning Task

    ERIC Educational Resources Information Center

    Jerman, Taylor; Kesner, Raymond P.; Hunsaker, Michael R.

    2006-01-01

    The dentate gyrus (DG) subregion of the hippocampus has been shown to be involved in encoding but not retrieval in a spatial maze task (modified Hebb-Williams maze). The first experiment in this study examined whether a lesion to the CA3 would contribute to a similar encoding deficit. A DG group was included in order to replicate previous results.…

  16. HiCoDG: a hierarchical data-gathering scheme using cooperative multiple mobile elements.

    PubMed

    Van Le, Duc; Oh, Hoon; Yoon, Seokhoon

    2014-12-17

    In this paper, we study mobile element (ME)-based data-gathering schemes in wireless sensor networks. Due to the physical speed limits of mobile elements, the existing data-gathering schemes that use mobile elements can suffer from high data-gathering latency. In order to address this problem, this paper proposes a new hierarchical and cooperative data-gathering (HiCoDG) scheme that enables multiple mobile elements to cooperate with each other to collect and relay data. In HiCoDG, two types of mobile elements are used: the mobile collector (MC) and the mobile relay (MR). MCs collect data from sensors and forward them to the MR, which will deliver them to the sink. In this work, we also formulated an integer linear programming (ILP) optimization problem to find the optimal trajectories for MCs and the MR, such that the traveling distance of MEs is minimized. Two variants of HiCoDG, intermediate station (IS)-based and cooperative movement scheduling (CMS)-based, are proposed to facilitate cooperative data forwarding from MCs to the MR. An analytical model for estimating the average data-gathering latency in HiCoDG was also designed. Simulations were performed to compare the performance of the IS and CMS variants, as well as a multiple traveling salesman problem (mTSP)-based approach. The simulation results show that HiCoDG outperforms mTSP in terms of latency. The results also show that CMS can achieve the lowest latency with low energy consumption.

  17. HiCoDG: A Hierarchical Data-Gathering Scheme Using Cooperative Multiple Mobile Elements †

    PubMed Central

    Van Le, Duc; Oh, Hoon; Yoon, Seokhoon

    2014-01-01

    In this paper, we study mobile element (ME)-based data-gathering schemes in wireless sensor networks. Due to the physical speed limits of mobile elements, the existing data-gathering schemes that use mobile elements can suffer from high data-gathering latency. In order to address this problem, this paper proposes a new hierarchical and cooperative data-gathering (HiCoDG) scheme that enables multiple mobile elements to cooperate with each other to collect and relay data. In HiCoDG, two types of mobile elements are used: the mobile collector (MC) and the mobile relay (MR). MCs collect data from sensors and forward them to the MR, which will deliver them to the sink. In this work, we also formulated an integer linear programming (ILP) optimization problem to find the optimal trajectories for MCs and the MR, such that the traveling distance of MEs is minimized. Two variants of HiCoDG, intermediate station (IS)-based and cooperative movement scheduling (CMS)-based, are proposed to facilitate cooperative data forwarding from MCs to the MR. An analytical model for estimating the average data-gathering latency in HiCoDG was also designed. Simulations were performed to compare the performance of the IS and CMS variants, as well as a multiple traveling salesman problem (mTSP)-based approach. The simulation results show that HiCoDG outperforms mTSP in terms of latency. The results also show that CMS can achieve the lowest latency with low energy consumption. PMID:25526356

  18. ETUDE - European Trade Union Distance Education.

    ERIC Educational Resources Information Center

    Creanor, Linda; Walker, Steve

    2000-01-01

    Describes transnational distance learning activities among European trade union educators carried out as part of the European Trade Union Distance Education (ETUDE) project, supported by the European Commission. Highlights include the context of international trade union distance education; tutor training course; tutors' experiences; and…

  19. Nuclear Regulatory Commission issuances

    SciTech Connect

    Not Available

    1994-03-01

    This report includes the issuances received during the specified period from Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors` Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM).

  20. Nuclear Regulatory Commission Issuances

    SciTech Connect

    1996-12-01

    This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM).

  1. State Emergency Response Commissions

    EPA Pesticide Factsheets

    The Governor of each state has designated a State Emergency Response Commission (SERC) that is responsible for implementing the Emergency Planning and Community Right-to-Know Act (EPCRA) provisions within its state.

  2. Commissioning the LCLS Injector

    SciTech Connect

    Akre, R.; Dowell, D.; Emma, P.; Frisch, J.; Gilevich, S.; Hays, G.; Hering, Ph.; Iverson, R.; Limborg-Deprey, C.; Loos, H.; Miahnahri, A.; Schmerge, J.; Turner, J.; Welch, J.; White, W.; Wu, J.; /SLAC

    2007-11-28

    The Linac Coherent Light Source (LCLS) is a SASE x-ray Free-Electron Laser (FEL) project presently under construction at SLAC. The injector section, from drive laser and RF photocathode gun through first bunch compressor chicane, was installed in fall 2006. Initial system commissioning with an electron beam was completed in August 2007, with the goal of a 1.2-micron emittance in a 1-nC bunch clearly demonstrated. The second phase of commissioning, including second bunch compressor and full linac, is planned for 2008, with FEL commissioning in 2009. We report experimental results and experience gained in the first phase of commissioning, including the photo-cathode drive laser, RF gun, photocathode, S-band and X-band RF systems, first bunch compressor, and the various beam diagnostics.

  3. SPEAR3 Commissioning

    SciTech Connect

    Harkay, K.; Sajaev, V.; Boland, M.J.; Tan, Y.E.; Krinsky, S.; Podobedov, B.; Decking, W.; Ropert, A.; Byrd, J.M.; Robin, D.; Scarvie, T.; Steier, C.; Fedurin, M.G.; Jines, P.; Chang, H.-P.; Kuo, C.-C.; Tsai, H.-J.; Yoon, M.H.; Boge, M.; Allison, S.; Bellomo, P.; /SLAC, SSRL /SOLEIL, Saint-Aubin

    2005-05-09

    The successful commissioning of the new SPEAR3 light source at the Stanford Synchrotron Radiation Laboratory (SSRL) will be reviewed. Orbit control, beam-based alignment, and an orbit interlock were commissioned. Orbit motion was characterized as a function of frequency. The linear optics was corrected for ID focusing and coupling errors. The nonlinear optics were investigated with dynamic aperture measurements as a function of energy and tune.

  4. Commission 51: Bioastronomy

    NASA Astrophysics Data System (ADS)

    Irvine, William; Ehrenfreund, Pascale; Boss, Alan; Cosmovici, Cristiano; Kwok, Sun; Levasseur-Regourd, Anny-Chantal; Morrison, David; Udry, Stephane

    2010-05-01

    Commission 51 met on August 12, 2009. Outgoing President Alan Boss chaired the meeting, and there were several dozen members present, including incoming President William Irvine, incoming Vice President Pascale Ehrenfreund, and outgoing Past President Karen Meech. Commission 51 (C51) was re-authorized for a term of six more years at the 2006 Prague General Assembly of the IAU, and hence comes up for renewal at the 2012 IAU General Assembly in Beijing, China.

  5. [Effect of 5-HT1A receptors in the hippocampal DG on active avoidance learning in rats].

    PubMed

    Jiang, Feng-ze; Lv, Jing; Wang, Dan; Jiang, Hai-ying; Li, Ying-shun; Jin, Qing-hua

    2015-01-01

    To investigate the effects of serotonin (5-HTIA) receptors in the hippocampal dentate gyrus (DG) on active avoidance learning in rats. Totally 36 SD rats were randomly divided into control group, antagonist group and agonist group(n = 12). Active avoidance learning ability of rats was assessed by the shuttle box. The extracellular concentrations of 5-HT in the DG during active avoidance conditioned reflex were measured by microdialysis and high performance liquid chromatography (HPLC) techniques. Then the antagonist (WAY-100635) or agonist (8-OH-DPAT) of the 5-HT1A receptors were microinjected into the DG region, and the active avoidance learning was measured. (1) During the active avoidance learning, the concentration of 5-HT in the hippocampal DG was significantly increased in the extinction but not establishment in the conditioned reflex, which reached 164.90% ± 26.07% (P <0.05) of basal level. (2) The microinjection of WAY-100635 (an antagonist of 5-HT1A receptor) into the DG did not significantly affect the active avoidance learning. (3) The microinjection of 8-OH-DPAT(an agonist of 5-HT1A receptor) into the DG significantly facilitated the establishment process and inhibited the extinction process during active avoidance conditioned reflex. The data suggest that activation of 5-HT1A receptors in hipocampal DG may facilitate active avoidance learning and memory in rats.

  6. A Functional Iron Oxide Nanoparticles Modified with PLA-PEG-DG as Tumor-Targeted MRI Contrast Agent.

    PubMed

    Xiong, Fei; Hu, Ke; Yu, Haoli; Zhou, Lijun; Song, Lina; Zhang, Yu; Shan, Xiuhong; Liu, Jianping; Gu, Ning

    2017-08-01

    Tumor targeting could greatly promote the performance of magnetic nanomaterials as MRI (Magnetic Resonance Imaging) agent for tumor diagnosis. Herein, we reported a novel magnetic nanoparticle modified with PLA (poly lactic acid)-PEG (polyethylene glycol)-DG (D-glucosamine) as Tumor-targeted MRI Contrast Agent. In this work, we took use of the D-glucose passive targeting on tumor cells, combining it on PLA-PEG through amide reaction, and then wrapped the PLA-PEG-DG up to the Fe3O4@OA NPs. The stability and anti phagocytosis of Fe3O4@OA@PLA-PEG-DG was tested in vitro; the MRI efficiency and toxicity was also detected in vivo. These functional magnetic nanoparticles demonstrated good biocompatibility and stability both in vitro and in vivo. Cell experiments showed that Fe3O4@OA@PLA-PEG-DG nanoparticles exist good anti phagocytosis and high targetability. In vivo MRI images showed that the contrast effect of Fe3O4@OA@PLA-PEG-DG nanoparticles prevailed over the commercial non tumor-targeting magnetic nanomaterials MRI agent at a relatively low dose. The DG can validly enhance the tumor-targetting effect of Fe3O4@OA@PLA-PEG nanoparticle. Maybe MRI agents with DG can hold promise as tumor-targetting development in the future.

  7. A combined ADER-DG and PML approach for simulating wave propagation in unbounded domains

    NASA Astrophysics Data System (ADS)

    Amler, Thomas G.; Hoteit, Ibrahim; Alkhalifah, Tariq A.

    2012-09-01

    In this work, we present a numerical approach for simulating wave propagation in unbounded domains which combines discontinuous Galerkin methods with arbitrary high order time integration (ADER-DG) and a stabilized modification of perfectly matched layers (PML). Here, the ADER-DG method is applied to Bérenger's formulation of PML. The instabilities caused by the original PML formulation are treated by a fractional step method that allows to monitor whether waves are damped in PML region. In grid cells where waves are amplified by the PML, the contribution of damping terms is neglected and auxiliary variables are reset. Results of 2D simulations in acoustic media with constant and discontinuous material parameters are presented to illustrate the performance of the method.

  8. Optimal placement and sizing of wind / solar based DG sources in distribution system

    NASA Astrophysics Data System (ADS)

    Guan, Wanlin; Guo, Niao; Yu, Chunlai; Chen, Xiaoguang; Yu, Haiyang; Liu, Zhipeng; Cui, Jiapeng

    2017-06-01

    Proper placement and sizing of Distributed Generation (DG) in distribution system can obtain maximum potential benefits. This paper proposes quantum particle swarm algorithm (QPSO) based wind turbine generation unit (WTGU) and photovoltaic (PV) array placement and sizing approach for real power loss reduction and voltage stability improvement of distribution system. Performance modeling of wind and solar generation system are described and classified into PQ\\PQ (V)\\PI type models in power flow. Considering the WTGU and PV based DGs in distribution system is geographical restrictive, the optimal area and DG capacity limits of each bus in the setting area need to be set before optimization, the area optimization method is proposed . The method has been tested on IEEE 33-bus radial distribution systems to demonstrate the performance and effectiveness of the proposed method.

  9. Short-channel drain current model for asymmetric heavily / lightly doped DG MOSFETs

    NASA Astrophysics Data System (ADS)

    Dutta, Pradipta; Syamal, Binit; Koley, Kalyan; Dutta, Arka; Sarkar, C. K.

    2017-08-01

    The paper presents a drain current model for double gate metal oxide semiconductor field effect transistors (DG MOSFETs) based on a new velocity saturation model that accounts for short-channel velocity saturation effect independently in the front and the back gate controlled channels under asymmetric front and back gate bias and oxide thickness. To determine the front and the back-channel velocity saturation, drain-induced barrier lowering is evaluated by effective gate voltages at the front and back gates obtained from surface potential at the threshold condition after considering symmetric and asymmetric front and back oxide thickness. The model also incorporates surface roughness scattering and ionized impurity scattering to estimate drain current for heavily / lightly doped channel for short-channel asymmetric DG MOSFET and a good agreement has been achieved with TCAD simulations, with a relative error of around 3-7%.

  10. Path Searching Based Fault Automated Recovery Scheme for Distribution Grid with DG

    NASA Astrophysics Data System (ADS)

    Xia, Lin; Qun, Wang; Hui, Xue; Simeng, Zhu

    2016-12-01

    Applying the method of path searching based on distribution network topology in setting software has a good effect, and the path searching method containing DG power source is also applicable to the automatic generation and division of planned islands after the fault. This paper applies path searching algorithm in the automatic division of planned islands after faults: starting from the switch of fault isolation, ending in each power source, and according to the line load that the searching path traverses and the load integrated by important optimized searching path, forming optimized division scheme of planned islands that uses each DG as power source and is balanced to local important load. Finally, COBASE software and distribution network automation software applied are used to illustrate the effectiveness of the realization of such automatic restoration program.

  11. Manufacturing Cost/Design Guide (MC/DG) for Aerospace Applications.

    DTIC Science & Technology

    1988-05-02

    temperature, operating environment, galvanic compatibility, available space, material allowables, heat-treatment, fracture mechanics , and fatigue...company team members and participating staff in this program to extend the MC/DG for composite materials and mechanically - fastened assemblies and to...Welding....... ...... ....... ..... 3-5 3.9 Mechanically Fastened Assembly ...... ..... 3-6 3.10 Sheet-Metal Discrete Parts. . 3-6 3.11 Superplastic

  12. DG-FTLE: Lagrangian coherent structures with high-order discontinuous-Galerkin methods

    NASA Astrophysics Data System (ADS)

    Nelson, Daniel A.; Jacobs, Gustaaf B.

    2015-08-01

    We present an algorithm for the computation of finite-time Lyapunov exponent (FTLE) fields using discontinuous-Galerkin (dG) methods in two dimensions. The algorithm is designed to compute FTLE fields simultaneously with the time integration of dG-based flow solvers of conservation laws. Fluid tracers are initialized at Gauss-Lobatto quadrature nodes within an element. The deformation gradient tensor, defined by the deformation of the Lagrangian flow map in finite time, is determined per element with high-order dG operators. Multiple flow maps are constructed from a particle trace that is released at a single initial time by mapping and interpolating the flow map formed by the locations of the fluid tracers after finite time integration to a unit square master element and to the quadrature nodes within the element, respectively. The interpolated flow maps are used to compute forward-time and backward-time FTLE fields at several times using dG operators. For a large finite integration time, the interpolation is increasingly poorly conditioned because of the excessive subdomain deformation. The conditioning can be used in addition to the FTLE to quantify the deformation of the flow field and identify subdomains with material lines that define Lagrangian coherent structures. The algorithm is tested on three benchmarks: an analytical spatially periodic gyre flow, a vortex advected by a uniform inviscid flow, and the viscous flow around a square cylinder. In these cases, the algorithm is shown to have spectral convergence.

  13. A new approach to extracting the RF parameters of asymmetric DG MOSFETs with the NQS effect

    NASA Astrophysics Data System (ADS)

    Pati, Sudhansu Kumar; Koley, Kalyan; Dutta, Arka; Mohankumar, N.; Sarkar, Chandan Kumar

    2013-11-01

    In analog circuit design an important parameter, from the perspective of superior device performance, is linearity. The DG MOSFET in asymmetric mode operation has been found to present a better linearity. In addition to that it provides, at the discretion of analog circuit designer, an additional degree of freedom, by providing independent bias control for the front and the back gates. Here a non-quasi-static (NQS) small signal model for DGMOSFET with asymmetric gate bias is proposed for extracting the parameters of the device using TCAD simulations. The parameters extracted here for analysis are the intrinsic front and back gate to drain capacitance, Cgd1 and Cgd2, the intrinsic front and back distributed channel resistance, Rgd1 and Rgd2 respectively, the transport delay, τm, and the inductance, Lsd. The parameter extraction model for an asymmetric DG MOSFET is validated with pre-established extracted parameter data, for symmetric DG MOSFET devices, from the available literature. The device simulation is performed with respect to frequency up to 100 GHz.

  14. Optimization of a stand-alone Solar PV-Wind-DG Hybrid System for Distributed Power Generation at Sagar Island

    NASA Astrophysics Data System (ADS)

    Roy, P. C.; Majumder, A.; Chakraborty, N.

    2010-10-01

    An estimation of a stand-alone solar PV and wind hybrid system for distributed power generation has been made based on the resources available at Sagar island, a remote area distant to grid operation. Optimization and sensitivity analysis has been made to evaluate the feasibility and size of the power generation unit. A comparison of the different modes of hybrid system has been studied. It has been estimated that Solar PV-Wind-DG hybrid system provides lesser per unit electricity cost. Capital investment is observed to be lesser when the system run with Wind-DG compared to Solar PV-DG.

  15. Struggle for Diversity of Languages in a Harmonising European Context: New Tasks for Teacher Education.

    ERIC Educational Resources Information Center

    Buchberger, Irina

    Education policies of the European Commission and the Council of Europe stress the importance of cultural and language diversity. A white book by the European Commission on education and training recommends that every European citizen be able to communicate in at least 3 of the 12 officially recognized languages of the European Union by the end of…

  16. Commissioning Experience of SNS

    SciTech Connect

    Plum, Michael A

    2007-07-01

    The Spallation Neutron Source accelerator complex consists of a 2.5 MeV H{sup -} front-end injector system, a 186 MeV normal-conducting linear accelerator, a 1 GeV superconducting linear accelerator, an accumulator ring, and associated beam transport lines. The linac was commissioned in five discrete runs, starting in 2002 and completed in 2005. The accumulator ring and associated beam transport lines were commissioned in two runs in January-February and April 2006. With the completed commissioning of the SNS accelerator, the facility has begun initial low-power operations. In the course of beam commissioning, most beam performance parameters and beam intensity goals have been achieved at low duty factor. A number of beam dynamics measurements have been performed, including emittance evolution, transverse coupling in the ring, beam instability thresholds, and beam distributions on the target. The commissioning results, achieved beam performance and initial operating experience of the SNS linac will be presented.

  17. Screening for gestational diabetes in Europe: where do we stand and how to move forward?: A scientific paper commissioned by the European Board & College of Obstetrics and Gynaecology (EBCOG).

    PubMed

    Benhalima, Katrien; Damm, Peter; Van Assche, André; Mathieu, Chantal; Devlieger, Roland; Mahmood, Tahir; Dunne, Fidelma

    2016-06-01

    The incidence of gestational diabetes (GDM) is rising globally and it represents an important modifiable risk factor for adverse pregnancy outcomes. GDM is also associated with negative long-term health outcomes for both mothers and offspring. Acceptance and implementation of the 2013 World Health Organization (WHO) criteria varies globally and within Europe. There is at present no consensus on the optimal approach to GDM screening in Europe. More uniformity in GDM screening across Europe will lead to an opportunity for more timely diagnosis and treatment for GDM in a greater number of women. More targeted research is necessary to evaluate optimal screening strategies based on the 2013 WHO criteria across different European populations with a focus on implementation strategy. Future research should address these important questions so that solid recommendations for GDM screening can be made to European health organizations based on screening uptake rates, maternal well-being, maternal and neonatal health outcomes, equity and cost-effectiveness. Here we describe the ongoing controversy on GDM screening and diagnosis, and provide an overview of important topics for future research concerning GDM screening in Europe.

  18. Commissioning of CEBAF

    SciTech Connect

    Andrew Hutton

    1994-06-01

    Construction of the CEBAF accelerator, a 4 GeV CW recirculating linac, is virtually complete. The 338 power sources and superconducting RF cavities, which have all run above nominal operating gradient in vertical tests (average 10.7 MeV/m), are installed. All the major components of the nine recirculation arcs are installed and aligned. Pre-commissioning was performed in parallel with construction. Ninety-nine superconducting cavities were operated simultaneously at the nominal gradient of 5 MeV/m. A maximum beam current of 110 PA CW (ZOO PA design) was reached. A cryomodule with eight cavities has operated at 8 MeV/m. Commissioning of the entire machine began in May 94. Results obtained during commissioning of the two linacs and the first arc are presented. 600 MeV beam is ready to be brought to the first experimental hall meeting a DOE milestone established in 1988.

  19. A Novel Rhamnose-Rich Hetero-exopolysaccharide Isolated from Lactobacillus paracasei DG Activates THP-1 Human Monocytic Cells

    PubMed Central

    Balzaretti, Silvia; Taverniti, Valentina; Fiore, Walter; Minuzzo, Mario; Ngo, Hansel N.; Ngere, Judith B.; Sadiq, Sohaib; Humphreys, Paul N.

    2016-01-01

    ABSTRACT Lactobacillus paracasei DG is a bacterial strain with recognized probiotic properties and is used in commercial probiotic products. However, the mechanisms underlying its probiotic properties are mainly unknown. In this study, we tested the hypothesis that the ability of strain DG to interact with the host is at least partly associated with its ability to synthesize a surface-associated exopolysaccharide (EPS). Comparative genomics revealed the presence of putative EPS gene clusters in the DG genome; accordingly, EPS was isolated from the surface of the bacterium. A sample of the pure EPS from strain DG (DG-EPS), upon nuclear magnetic resonance (NMR) and chemical analyses, was shown to be a novel branched hetero-EPS with a repeat unit composed of l-rhamnose, d-galactose, and N-acetyl-d-galactosamine in a ratio of 4:1:1. Subsequently, we demonstrated that DG-EPS displays immunostimulating properties by enhancing the gene expression of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), and particularly that of the chemokines IL-8 and CCL20, in the human monocytic cell line THP-1. In contrast, the expression of the cyclooxygenase enzyme COX-2 was not affected. In conclusion, DG-EPS is a bacterial macromolecule with the ability to boost the immune system either as a secreted molecule released from the bacterium or as a capsular envelope on the bacterial cell wall. This study provides additional information about the mechanisms supporting the cross talk between L. paracasei DG and the host. IMPORTANCE The consumption of food products and supplements called probiotics (i.e., containing live microbial cells) to potentially prevent or treat specific diseases is constantly gaining popularity. The lack of knowledge on the precise mechanisms supporting their potential health-promoting properties, however, greatly limits a more appropriate use of each single probiotic strain. In this context, we studied a well-known probiotic

  20. A Novel Rhamnose-Rich Hetero-exopolysaccharide Isolated from Lactobacillus paracasei DG Activates THP-1 Human Monocytic Cells.

    PubMed

    Balzaretti, Silvia; Taverniti, Valentina; Guglielmetti, Simone; Fiore, Walter; Minuzzo, Mario; Ngo, Hansel N; Ngere, Judith B; Sadiq, Sohaib; Humphreys, Paul N; Laws, Andrew P

    2017-02-01

    Lactobacillus paracasei DG is a bacterial strain with recognized probiotic properties and is used in commercial probiotic products. However, the mechanisms underlying its probiotic properties are mainly unknown. In this study, we tested the hypothesis that the ability of strain DG to interact with the host is at least partly associated with its ability to synthesize a surface-associated exopolysaccharide (EPS). Comparative genomics revealed the presence of putative EPS gene clusters in the DG genome; accordingly, EPS was isolated from the surface of the bacterium. A sample of the pure EPS from strain DG (DG-EPS), upon nuclear magnetic resonance (NMR) and chemical analyses, was shown to be a novel branched hetero-EPS with a repeat unit composed of l-rhamnose, d-galactose, and N-acetyl-d-galactosamine in a ratio of 4:1:1. Subsequently, we demonstrated that DG-EPS displays immunostimulating properties by enhancing the gene expression of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), and particularly that of the chemokines IL-8 and CCL20, in the human monocytic cell line THP-1. In contrast, the expression of the cyclooxygenase enzyme COX-2 was not affected. In conclusion, DG-EPS is a bacterial macromolecule with the ability to boost the immune system either as a secreted molecule released from the bacterium or as a capsular envelope on the bacterial cell wall. This study provides additional information about the mechanisms supporting the cross talk between L. paracasei DG and the host. The consumption of food products and supplements called probiotics (i.e., containing live microbial cells) to potentially prevent or treat specific diseases is constantly gaining popularity. The lack of knowledge on the precise mechanisms supporting their potential health-promoting properties, however, greatly limits a more appropriate use of each single probiotic strain. In this context, we studied a well-known probiotic, Lactobacillus

  1. MSRR-1 Commissioning

    NASA Image and Video Library

    2009-11-02

    ISS021-E-018978 (2 Nov. 2009) --- European Space Agency astronaut Frank De Winne, Expedition 21 commander, works with Materials Science Laboratory (MSL) hardware in the Destiny laboratory of the International Space Station.

  2. 78 FR 12412 - Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-22

    ... From the Federal Register Online via the Government Publishing Office ] SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on March 21, 2013, in Harrisburg...

  3. 77 FR 28420 - Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... From the Federal Register Online via the Government Publishing Office SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on June 7, 2012, in Binghamton, New...

  4. 77 FR 70204 - Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-23

    ... From the Federal Register Online via the Government Publishing Office SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on December 14, 2012, in Annapolis...

  5. 78 FR 52601 - Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on September 19, 2013, in Binghamton, New York. Details concerning the matters to be addressed at the business meeting are contained in the...

  6. High Efficiency Apoptosis Induction in Breast Cancer Cell Lines by MLN4924/2DG Co-Treatment.

    PubMed

    Oladghaffari, Maryam; Islamian, Jalil Pirayesh; Baradaran, Behzad; Monfared, Ali Shabestani; Farajollahi, Alireza; Shanehbandi, Dariush; Mohammadi, Mohsen

    2015-01-01

    2-deoxy-D-Glucose (2DG) causes cytotoxicity in cancer cells by disrupting thiol metabolism. It is an effective component in therapeutic strategies. It targets the metabolism of cancer cells with glycolysis inhibitory activity. On the other hand, MLN4924, a newly discovered investigational small molecule inhibitor of NAE (NEDD8 activating enzyme), inactivates SCF E3 ligase and causes accumulation of its substrates which triggers apoptosis. Combination of these components might provide a more efficient approach to treatment. In this research, 2DG and MLN4924 were co-applied to breast cancer cells (MCF-7 and SKBR-3) and cytotoxic and apoptotic activity were evaluated the by Micro culture tetrazolium test (MTT), TUNEL and ELISA methods. Caspase3 and Bcl2 genes expression were evaluated by real time Q-PCR methods. The results showed that MLN4924 and MLN4924/2DG dose-dependently suppressed the proliferation of MCF7 and SKBR-3 cells. Cell survival of breast cancer cells exposed to the combination of 2DG/MLN4924 was decreased significantly compared to controls (p<0.05), while 2DG and MLN4924 alone had less pronounced effects on the cells. The obtained results suggest that 2DG/MLN4924 is much more efficient in breast cancer cell lines with enhanced cytotoxicity via inducing a apoptosis cell signaling gene, caspase-3.

  7. Commissioning dose computation models for spot scanning proton beams in water for a commercially available treatment planning system

    PubMed Central

    Zhu, X. R.; Poenisch, F.; Lii, M.; Sawakuchi, G. O.; Titt, U.; Bues, M.; Song, X.; Zhang, X.; Li, Y.; Ciangaru, G.; Li, H.; Taylor, M. B.; Suzuki, K.; Mohan, R.; Gillin, M. T.; Sahoo, N.

    2013-01-01

    Purpose: To present our method and experience in commissioning dose models in water for spot scanning proton therapy in a commercial treatment planning system (TPS). Methods: The input data required by the TPS included in-air transverse profiles and integral depth doses (IDDs). All input data were obtained from Monte Carlo (MC) simulations that had been validated by measurements. MC-generated IDDs were converted to units of Gy mm2/MU using the measured IDDs at a depth of 2 cm employing the largest commercially available parallel-plate ionization chamber. The sensitive area of the chamber was insufficient to fully encompass the entire lateral dose deposited at depth by a pencil beam (spot). To correct for the detector size, correction factors as a function of proton energy were defined and determined using MC. The fluence of individual spots was initially modeled as a single Gaussian (SG) function and later as a double Gaussian (DG) function. The DG fluence model was introduced to account for the spot fluence due to contributions of large angle scattering from the devices within the scanning nozzle, especially from the spot profile monitor. To validate the DG fluence model, we compared calculations and measurements, including doses at the center of spread out Bragg peaks (SOBPs) as a function of nominal field size, range, and SOBP width, lateral dose profiles, and depth doses for different widths of SOBP. Dose models were validated extensively with patient treatment field-specific measurements. Results: We demonstrated that the DG fluence model is necessary for predicting the field size dependence of dose distributions. With this model, the calculated doses at the center of SOBPs as a function of nominal field size, range, and SOBP width, lateral dose profiles and depth doses for rectangular target volumes agreed well with respective measured values. With the DG fluence model for our scanning proton beam line, we successfully treated more than 500 patients from

  8. Nuclear Regulatory Commission issuances

    SciTech Connect

    1997-09-01

    This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors` Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM). The summaries and headnotes preceding the opinions reported herein are not to be deemed a part of those opinions or have any independent legal significance.

  9. Conservation Commissions in Massachusetts.

    ERIC Educational Resources Information Center

    Scheffey, Andrew J. W.

    The Conservation Foundation reported on the experience of a resource development specialist in the state of Massachusetts on the public's growing concern for environmental quality. After tracing the origins of the Massachusetts movement, the report draws upon a variety of specific state experiences to illustrate the commission's growing pains and…

  10. Legal Commission Report

    ERIC Educational Resources Information Center

    American Indian Journal, 1977

    1977-01-01

    The Legal Commission of the International Non-Governmental Organizations Conference on Discrimination Against Indigenous Populations adopted the following agenda: legal status of indigenous populations; the land question; indigenous laws and courts; discrimination against indigenous peoples in existing laws and their application; and creation of…

  11. Ethics Commission Member's Comment.

    ERIC Educational Resources Information Center

    Riley, Sue Spayth

    1988-01-01

    Presents a National Association for the Education of Young Children (NAEYC) Ethics Commission member's comments and suggestions about how early childhood educators can best make sound decisions about the ethical dilemma of the welfare of the child and the confidentiality of its divorced parents. (BB)

  12. Expedition 29 State Commission

    NASA Image and Video Library

    2011-11-12

    Expedition 29 Soyuz Commander Anton Shkaplerov speaks during the State Commission meeting to approve the Soyuz launch of Expedition 29 to the International Space Station, Saturday, Nov. 12, 2011 at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch November 14 from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  13. Expedition 29 State Commission

    NASA Image and Video Library

    2011-11-12

    Expedition 29 Russian Flight Engineer Anatoly Ivanishin speaks during the State Commission meeting to approve the Soyuz launch of Expedition 29 to the International Space Station, Saturday, Nov. 12, 2011 at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch November 14 from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  14. Expedition 29 State Commission

    NASA Image and Video Library

    2011-11-12

    NASA Expedition 29 backup crew member Joseph Acaba speaks during the State Commission meeting to approve the Soyuz launch of Expedition 29 to the International Space Station, Saturday, Nov. 12, 2011 at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch November 14 from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  15. Expedition 28 State Commission

    NASA Image and Video Library

    2011-06-06

    Expedition 28 NASA Flight Engineer Mike Fossum stands during the State Commission meeting to approve the Soyuz launch of Expedition 28 to the International Space Station, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on Tuesday, June 8, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  16. Expedition 29 State Commission

    NASA Image and Video Library

    2011-11-12

    Michael Suffredini, Manager, International Space Station (ISS) Program speaks during the State Commission meeting to approve the Soyuz launch of Expedition 29 to the International Space Station, Saturday, Nov. 12, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch November 14 from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  17. Expedition 28 State Commission

    NASA Image and Video Library

    2011-06-06

    Expedition 28 Russian backup Flight Engineer Oleg Kononenko is seen seated during the State Commission meeting to approve the Soyuz launch of Expedition 28 to the International Space Station, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on Tuesday, June 8, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  18. Expedition 33 State Commission

    NASA Image and Video Library

    2012-10-22

    Members of the State Commission meet at the Cosmosnaut hotel to approve the Soyuz launch of Expedition 33/34 Flight Engineer Kevin Ford of NASA, Soyuz Commander Oleg Novitskiy and Flight Engineer Evgeny Tarelkin of ROSCOSMOS on Monday, Oct. 22, 2012 in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  19. Expedition 28 State Commission

    NASA Image and Video Library

    2011-06-06

    Michael Suffredini, Manager, International Space Station (ISS) Program, center, speaks during the State Commission meeting to approve the Soyuz launch of Expedition 28 to the International Space Station, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on on Tuesday, June 8, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  20. Expedition 29 State Commission

    NASA Image and Video Library

    2011-11-12

    Vladimir Popovkin, Head of the Russian Federal Space Agency (ROSCOSMOS) speaks during the State Commission meeting to approve the Soyuz launch of Expedition 29 to the International Space Station, Saturday, Nov. 12, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch November 14 from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  1. Expedition 41 State Commission

    NASA Image and Video Library

    2014-09-24

    Michael Suffredini, NASA International Space Station Program Manager, speaks during the State Commission meeting to approve the Soyuz launch of Expedition 41 to the International Space Station, Wednesday, Sept. 24, 2014, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch Sept. 26 from the Baikonur Cosmodrome. Photo Credit: (NASA/Aubrey Gemignani)

  2. Expedition 29 State Commission

    NASA Image and Video Library

    2011-11-12

    Expedition 29 backup crew member Sergei Revin speaks during the State Commission meeting to approve the Soyuz launch of Expedition 29 to the International Space Station, Saturday, Nov. 12, 2011 at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch November 14 from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  3. Expedition 28 State Commission

    NASA Image and Video Library

    2011-06-06

    Vladimir Popovkin, Head of the Russian Federal Space Agency (ROSCOSMOS) speaks during the State Commission meeting to approve the Soyuz launch of Expedition 28 to the International Space Station, Monday, June 6, 2011, at the Cosmonaut Hotel in Baikonur, Kazakhstan. The mission is set to launch on Tuesday, June 8, from the Baikonur Cosmodrome. Photo Credit: (NASA/Carla Cioffi)

  4. Nuclear Regulatory Commission issuances

    SciTech Connect

    1997-11-01

    This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors` Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM). The summaries and headnotes preceding the opinions reported herein are not to be deemed a part of those opinions or have any independent legal significance.

  5. Commission on Liberal Learning

    ERIC Educational Resources Information Center

    Hazzard, George W.

    1976-01-01

    Study emphasis within the Commission on Liberal Learning during the year was on the role of liberal education in the society of the future. The relationship of undergraduate liberal education to the world macro-problem--population growth, industrial production, food, materials and energy scarcities, pollution and environmental degradation--was…

  6. Federal Election Commission.

    ERIC Educational Resources Information Center

    Elliot, Lee Ann

    1996-01-01

    Presents a concise overview of the responsibilities, membership, structure, and requirements of the Federal Election Commission (FEC). Created in 1974, the FEC oversees the financial activities of candidates and political parties. Discusses corporate and union political action committees (PACs) as well as contribution limits and prohibitions. (MJP)

  7. Nuclear Regulatory Commission Issuances

    SciTech Connect

    Not Available

    1994-10-01

    This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM). The summaries and headnotes preceding the opinions reported herein are not to be deemed a part of those opinions or have any independent legal significance.

  8. The European Spallation Source

    SciTech Connect

    Peggs, S; Eshraqi, M; Hahn, H; Jansson, A; Lindroos, M; Ponton, A; Rathsman, K; Trahern, G; Bousso, S; Calaga, R; Devanz, G; Duperrier, R D; Eguia, J; Gammino, S; Moller, S P; Oyon, C; Ruber, R.J.M.Y.; Satogata, T

    2011-03-01

    The European Spallation Source (ESS) is a 5 MW, 2.5 GeV long pulse proton linac, to be built and commissioned in Lund, Sweden. The Accelerator Design Update (ADU) project phase is under way, to be completed at the end of 2012 by the delivery of a Technical Design Report. Improvements to the 2003 ESS design will be summarised, and the latest design activities will be presented.

  9. A comparison of Fuel Cell Testing protocols - A case study: Protocols used by the U.S. Department of Energy, European Union, International Electrotechnical Commission/Fuel Cell Testing and Standardization Network, and Fuel Cell Technical Team

    NASA Astrophysics Data System (ADS)

    Bloom, Ira; Walker, Lee K.; Basco, John K.; Malkow, Thomas; Saturnio, Antonio; De Marco, Giancarlo; Tsotridis, Georgios

    2013-12-01

    Argonne National Laboratory (Argonne) and the Joint Research Centre-Institute for Energy and Transport (JRC-IET) collaborated to understand the aging behavior of polymer-electrolyte membrane stacks when operated under different duty cycles. The duty cycles were that used by the U.S. Department of Energy (DST) and the US Fuel Cell Council; the New European Drive Cycle (ECE R15); that used in IEC-TS62282-7-1 (IEC) and Fuel Cell Testing and Standardization Network; and the one proposed by the US Driving Research and Innovation for Vehicle Efficiency and Energy Sustainability Fuel Cell Technical Team (FCTT). The stacks were cycled using the duty profile in each protocol for 200 h; stack performance was measured every 100 h. Analysis of the relative changes in the average cell potentials at 180 A showed that the rate of performance decline could be ordered as IEC > ECE R15, the latter being slightly greater than or approximately equal to DST and FCTT. Comparing this ordering to the length of time at full power in the duty cycle with the degradation rates shows that they are related. Most likely, the underlying cause of performance decline can be attributed to the manner in which the product water interacts with the stack components.

  10. A quality assessment of the MARS crop yield forecasting system for the European Union

    NASA Astrophysics Data System (ADS)

    van der Velde, Marijn; Bareuth, Bettina

    2015-04-01

    Timely information on crop production forecasts can become of increasing importance as commodity markets are more and more interconnected. Impacts across large crop production areas due to (e.g.) extreme weather and pest outbreaks can create ripple effects that may affect food prices and availability elsewhere. The MARS Unit (Monitoring Agricultural ResourceS), DG Joint Research Centre, European Commission, has been providing forecasts of European crop production levels since 1993. The operational crop production forecasting is carried out with the MARS Crop Yield Forecasting System (M-CYFS). The M-CYFS is used to monitor crop growth development, evaluate short-term effects of anomalous meteorological events, and provide monthly forecasts of crop yield at national and European Union level. The crop production forecasts are published in the so-called MARS bulletins. Forecasting crop yield over large areas in the operational context requires quality benchmarks. Here we present an analysis of the accuracy and skill of past crop yield forecasts of the main crops (e.g. soft wheat, grain maize), throughout the growing season, and specifically for the final forecast before harvest. Two simple benchmarks to assess the skill of the forecasts were defined as comparing the forecasts to 1) a forecast equal to the average yield and 2) a forecast using a linear trend established through the crop yield time-series. These reveal a variability in performance as a function of crop and Member State. In terms of production, the yield forecasts of 67% of the EU-28 soft wheat production and 80% of the EU-28 maize production have been forecast superior to both benchmarks during the 1993-2013 period. In a changing and increasingly variable climate crop yield forecasts can become increasingly valuable - provided they are used wisely. We end our presentation by discussing research activities that could contribute to this goal.

  11. Commissioning the Majorana Demonstrator

    NASA Astrophysics Data System (ADS)

    Xu, Wenqin; Majorana Collaboration

    2016-03-01

    The Majorana Demonstrator deploys high purity germanium (HPGe) detector modules to search for neutrinoless double beta (0 νββ) decay in 76Ge. The experiment is aimed at demonstrating the technical feasibility and low backgrounds for a next generation Ge-based BBz experiment. The program of testing and commissioning the Demonstrator modules is a critical step to debug and improve the experimental apparatus, to establish and refine operational procedures, and to develop data analysis tools. In this talk, we will discuss our experience commissioning the Demonstrator modules and show how this program leads to successful data-taking. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics, the Particle Astrophysics and Nuclear Physics Programs of the National Science Foundation, and the Sanford Underground Research Facility.

  12. Commission 42: Close Binaries

    NASA Astrophysics Data System (ADS)

    Rucinski, Slavek M.; Ribas, Ignasi; Giménez, Alvaro; Harmanec, Petr; Hilditch, Ronald W.; Kaluzny, Janusz; Niarchos, Panayiotis; Nordström, Birgitta; Oláh, Katalin; Richards, Mercedes T.; Scarfe, Colin D.; Sion, Edward M.; Torres, Guillermo; Vrielmann, Sonja

    2010-05-01

    During the commission business session, the past President presented the new Organizing Committee which was selected by the OC through a e-mail vote conducted during the months before the Rio de Janeiro General Assembly. The new OC will consist of Ignasi Ribas (President), Mercedes Richards (Vice President), and Slavek Rucinski (Past President) with the members: David Bradstreet, Petr Harmanec, Janusz Kaluzny, Joanna Mikolajewska, Ulisse Munari, Panos Niarchos, Katalin Olah, Theo Pribulla, Colin Scarfe and Guillermo Torres.

  13. Nuclear Regulatory Commission issuances

    SciTech Connect

    1996-04-01

    This report includes the issuances received during the April 1996 reporting period from the Commission, the Atomic Safety and Licensing Boards, the Administrative Law Judges, the Directors` Decisions, and the Decisions on Petitions for Rulemaking. Included are issuances pertaining to: (1) Yankee Nuclear Power Station, (2) Georgia Tech Research Reactor, (3) River Bend Station, (4) Millstone Unit 1, (5) Thermo-Lag fire barrier material, and (6) Louisiana Energy Services.

  14. Expedition 39 State Commission

    NASA Image and Video Library

    2014-03-24

    General Director of the Russian Federal Space Agency, Roscosmos, Oleg Ostapenko, as seen during the State Commission meeting to approve the Soyuz rocket launch of Expedition 39 Soyuz Commander Alexander Skvortsov of the Russian Federal Space Agency, Flight Engineer Steve Swanson of NASA, and Flight Engineer Oleg Artemyev of Roscosmos on a six month mission aboard the International Space Station, Monday, March 24, 2014 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  15. Expedition 38 State Commission

    NASA Image and Video Library

    2013-11-06

    Members of the State Commission meet to approve the Soyuz rocket launch of Expedition 38 Soyuz Commander Mikhail Tyurin of Roscosmos, Flight Engineer Koichi Wakata of the Japan Aerospace Exploration Agency, and, Flight Engineer Rick Mastracchio of NASA for a six month mission aboard the International Space Station, Wednesday, Nov. 6, 2013 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  16. Expedition 38 State Commission

    NASA Image and Video Library

    2013-11-06

    President of RSC Energia, Designer General V.A. Lopota, talks during the State Commission meeting to approve the Soyuz rocket launch of Expedition 38 Soyuz Commander Mikhail Tyurin of Roscosmos, Flight Engineer Koichi Wakata of the Japan Aerospace Exploration Agency, and, Flight Engineer Rick Mastracchio of NASA for a six month mission aboard the International Space Station, Wednesday, Nov. 6, 2013 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  17. Expedition 38 State Commission

    NASA Image and Video Library

    2013-11-06

    JAXA (Japan Aerospace Exploration Agency) President Naoki Okumura talks during the State Commission meeting to approve the Soyuz rocket launch of Expedition 38 Soyuz Commander Mikhail Tyurin of Roscosmos, Flight Engineer Koichi Wakata of the Japan Aerospace Exploration Agency, and, Flight Engineer Rick Mastracchio of NASA for a six month mission aboard the International Space Station, Wednesday, Nov. 6, 2013 at the Cosmonaut Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Bill Ingalls)

  18. Duarte (DG) galactosemia: a pilot study of biochemical and neurodevelopmental assessment in children detected by newborn screening.

    PubMed

    Ficicioglu, Can; Thomas, Nina; Yager, Claire; Gallagher, Paul R; Hussa, Christie; Mattie, Andrea; Day-Salvatore, Debra L; Forbes, Brian J

    2008-12-01

    Newborn screening for galactosemia has shown a high prevalence of partial galactose uridyl transferase deficiencies such as Duarte (DG) galactosemia. To determine whether (a) there is any clinical impact of DG galactosemia on development (b) there is a relationship between outcome and biochemical parameters in patients who receive no treatment. Twenty-eight children with DG galactosemia. Group-I-17 children had a lactose restricted diet in the first year of life. Group-II-11 children had a regular diet since birth. Developmental, physical, and ophthalmologic assessments were completed on both DG groups. RBC gal-1-p and urine galactitol were monitored during the follow-up visits in every child with DG galactosemia. Gal-1-p, urine galactitol, liver function tests, and FSH were tested at the time of study visit. The groups had statistically significant differences on RBC gal-1-p and urine galactitol at the 2 week, 1 month, 6 month, and 1 year time points. There was no statistical difference of gal-1-p or urine galactitol in group-I and -II at the time of study. The groups had statistically significant differences on adaptive scores, but not on language or IQ. None of the DG subjects had abnormal liver function at the time of diagnosis or the study visit. The FSH levels were normal. There were no statistically significant relationships between the first year metabolic values and developmental outcomes. The data presented here indicate that clinical and developmental outcomes in DG galactosemics are good regardless of any diet changes.

  19. Division XII / Commission 5 / Working Group Libraries

    NASA Astrophysics Data System (ADS)

    Grothkopf, Uta; Murtagh, Fionn; Birdie, Christina; Bishop, Marsha; Bobis, Laurence; Coletti, Donna J.; Corbin, Brenda G.; Gomez, Monique; Naimova, Halima

    The IAU Working Group on Libraries was officially recognized for the first time in the Transactions of the IAU XXIA Reports on Astronomy (McNally 1991), but librarians were involved in Commission 5 activities before that (largely due to the efforts of George A. Wilkins, president of the Commission from 1982 to 1988, see Transactions of the IAU XXA Reports on Astronomy, Swings 1988). Wayne Warren (NASA GSFC, MD, USA) and Helen Knudsen (Calech, CA, USA) were the group's first chairpersons, Brenda Corbin (U.S. Naval Observatory) became Helen Knudsen's successor in 1990. Since 1996, Fionn Murtagh (School of Computer Science, Queen's University of Belfast, Northern Ireland) and Uta Grothkopf (European Southern Observatory, Germany) have been co-chairs.

  20. DG Connect Funded Projects on Information and Communication Technologies (ICT) for Old Age People: Beyond Silos, CareWell and SmartCare.

    PubMed

    Keijser, W; de Manuel-Keenoy, E; d'Angelantonio, M; Stafylas, P; Hobson, P; Apuzzo, G; Hurtado, M; Oates, J; Bousquet, J; Senn, A

    2016-01-01

    Information and communication technologies (ICT) are promising for the long-term care of older and frequently frail people. These innovations can improve health outcomes, quality of life and efficiency of care processes, while supporting independent living. However, they may be disruptive innovations. As all European member states are facing an increasing complexity of health and social care, good practices in ICT should be identified and evaluated. Three projects funded by DG CNECT are related to Active and Healthy Ageing (AHA) and frailty: (i) BeyondSilos, dealing with independent living and integrated services, (ii) CareWell, providing integrated care coordination, patient empowerment and home support and (iii) SmartCare, proposing a common set of standard functional specifications for an ICT platform enabling the delivery of integrated care to older patients. The three projects described in this paper provide a unique pan-European research field to further study implementation efforts and outcomes of new technologies. Below, based on a description of the projects, the authors display four domains that are in their views fundamental for in-depth exploration of heterogeneity in the European context: 1. Definition of easily transferable, high level pathways with solid evidence-base; 2. Change management in implementing ICT enabled integrated care; 3. Evaluation and data collection methodologies based on existing experience with MAST and MEDAL methodologies; and 4. Construction of new models for delivery of health and social care. Understanding complementarity, synergies and differences between the three unique projects can help to identify a more effective roll out of best practices within a varying European context.

  1. Evaluation of Superimposed Sequence Components of Currents based Islanding Detection Scheme during DG Interconnections

    NASA Astrophysics Data System (ADS)

    Sareen, Karan; Bhalja, Bhavesh R.; Maheshwari, Rudra Prakash

    2016-02-01

    A new islanding detection scheme for distribution network containing different types of distributed generations (DGs) is presented in this paper. The proposed scheme is based on acquiring three phase current samples for full cycle duration of each simulation case of islanding/non-islanding conditions at the point of common coupling (PCC) of the targeted DG. Afterwards, superimposed positive & negative sequence components of current are calculated and continuously compared with pre-determined threshold values. Performance of the proposed scheme has been evaluated on diversified islanding and non-islanding events which were generated by modeling standard IEEE 34-bus system using PSCAD/EMTDC software package. The proposed scheme is capable to detect islanding condition rapidly even for perfect power balance situation for both synchronous and inverter based DGs. Furthermore, it remains stable during non-islanding events such as tripping of multiple DGs and different DG interconnection operating conditions. Therefore, the proposed scheme avoids nuisance tripping during diversified non-islanding events. At the end, comparison of the proposed scheme with the existing scheme clearly indicates its advantage over the existing scheme.

  2. Pseudosolubilized n-alkanes analysis and optimization of biosurfactants production by Pseudomonas sp. DG17.

    PubMed

    Hua, Fei; Wang, Hong Qi; Zhao, Yi Cun; Yang, Yan

    2015-05-01

    The pseudosolubilized medium-chain-length n-alkanes during biodegradation process, and optimization of medium composition and culture conditions for rhamnolipid production by Pseudomonas sp. DG17 using Plackett-Burman design and Box-Behnken design, were examined in this study. The results showed that pseudosolubilized concentration of C14 to C20 n-alkanes was higher than that of C24 to C26. After incubation for 120 h, pseudosolubilized C16H34 increased to 2.63 ± 0.21 mg. Meanwhile, biodegradation rates of n-alkanes decreased along with the increase of carbon chain length. Carbon-14 assay suggested that nonlabeled C14H30, C16H34, and C20H42 inhibited the biodegradation of (14)C n-octadecane, and Pseudomonas sp. DG17 utilized different alkanes simultaneously. Three significant variables (substrate concentration, salinity, and C/N) that could influence rhamnolipid production were screened by Plackett-Burman design. Results of Box-Behnken design suggested that rhamnolipid concentration could be achieved at 91.24 mg L(-1) (observed value) or 87.92 mg L(-1) (predicted value) with the optimal levels of concentration, salinity, and C/N of 400 mg L(-1), 1.5 %, and 45, respectively.

  3. Novel 2DG-based harmine derivatives for targeted cancer therapy

    NASA Astrophysics Data System (ADS)

    Wang, Aqin; Chen, Yuqi; Chen, Wei R.; Gu, Yueqing

    2013-02-01

    Harmine is a beta-carboline alkaloid from the plant Peganum harmala. These alkaloids were stimulated by their promising antitumor activities in the recent years. In this study, we designed and synthesized two harmine derivatives #1and #2 modified at position-9 of harmine with ethyl and phenylpropyl, respectively. To improve the tumor targeting capability, #1' and #2' were synthesized by conjugating 2-amino-2-deoxy-D-glucose (2DG) to the derivatives #1 and #2, respectively. The MTT assays of all these compounds in vitro against L02, HepG2 showed all compounds had low toxicity to normal cells (L02) and significantly enhanced carcinoma cell inhibitory rate compared to harmine. Cytotoxicity against liver cancer cell lines of compound #1' #2' is higher than #1 #2, and even the compound #2' is better than positive drug 5-FU. The compound #2', a novel 2DG-based harmine derivatives, could become a promising drug for targeted cancer therapy and combination therapy with other antitumor drugs.

  4. Application of the DG-1199 methodology to the ESBWR and ABWR.

    SciTech Connect

    Kalinich, Donald A.; Gauntt, Randall O.; Walton, Fotini

    2010-09-01

    Appendix A-5 of Draft Regulatory Guide DG-1199 'Alternative Radiological Source Term for Evaluating Design Basis Accidents at Nuclear Power Reactors' provides guidance - applicable to RADTRAD MSIV leakage models - for scaling containment aerosol concentration to the expected steam dome concentration in order to preserve the simplified use of the Accident Source Term (AST) in assessing containment performance under assumed design basis accident (DBA) conditions. In this study Economic and Safe Boiling Water Reactor (ESBWR) and Advanced Boiling Water Reactor (ABWR) RADTRAD models are developed using the DG-1199, Appendix A-5 guidance. The models were run using RADTRAD v3.03. Low Population Zone (LPZ), control room (CR), and worst-case 2-hr Exclusion Area Boundary (EAB) doses were calculated and compared to the relevant accident dose criteria in 10 CFR 50.67. For the ESBWR, the dose results were all lower than the MSIV leakage doses calculated by General Electric/Hitachi (GEH) in their licensing technical report. There are no comparable ABWR MSIV leakage doses, however, it should be noted that the ABWR doses are lower than the ESBWR doses. In addition, sensitivity cases were evaluated to ascertain the influence/importance of key input parameters/features of the models.

  5. Evidence for an X-Ray Jet in DG Tauri A?

    NASA Astrophysics Data System (ADS)

    Güdel, M.; Skinner, S. L.; Briggs, K. R.; Audard, M.; Arzner, K.; Telleschi, A.

    2005-06-01

    We present evidence for an X-ray jet in the T Tauri star DG Tau A based on Chandra ACIS data. DG Tau A, a jet-driving classical T Tauri star with a flat infrared spectrum, reveals an unusual X-ray spectrum that requires two thermal components with different intervening absorption column densities. The softer component shows a low temperature of T~2.9 MK, and its absorption is compatible with the stellar optical extinction (hydrogen column density NH~5×1021 cm-2). In contrast, the harder component reveals a temperature (22 MK) characteristic of active T Tauri stars, but its emission is more strongly absorbed (NH~2.8×1022 cm-2). Furthermore, the high-resolution ACIS-S image reveals a weak excess of soft (0.5-2 keV) counts at distances of 2"-4" from the star precisely along the optical jet, with a suggestive concentration at 4", where a bow shock-like structure has previously been identified in optical line observations. The energy distribution of these photons is similar to those of the stellar soft component. We interpret the soft spectral component as originating from shocks at the base of the jet, with shock-heating continuing out to a distance of at least 500 AU along the jet, whereas the hard component is most likely coronal or magnetospheric as in other young stellar systems.

  6. 3-D elastic wave propagation on regional to global scales using an ADER-DG method

    NASA Astrophysics Data System (ADS)

    Wenk, S.; Pelties, C.; Igel, H.

    2012-04-01

    The complex 3-D material property distributions inside the Earth and detailed information on the physical dynamics of an earthquake require robust numerical methods to generate accurate results in form of seismograms. Furthermore, these simulations must be highly scalable on HPC infrastructures for realistic simulations. Possible applications are regional forward modeling studies for hazard assessment or seismic tomography on a global scale to illuminate the deep Earth's interior. The Arbitrary high-order DERivative Discontinuous Galerkin (ADER-DG) method is well suited to simulate 3-D elastic wave propagation to capture the high frequency content of the wavefield over long propagation distances. It is able to incorporate fine-scale Earth structures on a regional to global scale using flexible tetrahedral meshing and features like h-p adaptivity and local time stepping (Dumbser et al. 2007). We were able to successfully benchmark seismograms originating from simpler 1-D layered Earth models with synthetics of the well-tested spectral-element method. The verification towards 3-D models is carried out on a regional model of Europe taking the topography of the Earth's surface and Mohorovicic discontinuity into account using the EPcrust model of Molinari et al. (2011) on top of the AK135 model of Kennett et al. (1995). For the L'Aquila earthquake (Italy) in 2009 we compare synthetic seismograms of our ADER-DG solver with real data up to 20s period and can show a very good fit between the signals.

  7. Enhanced electrochemical performance from 3DG/LiFePO4/G sandwich cathode material

    NASA Astrophysics Data System (ADS)

    Du, Yahui; Tang, Yufeng; Chang, Chengkang

    2017-08-01

    In this paper, we have successfully synthesized a three dimensional graphene/LiFePO4/graphene (3DG/LFP/G) sandwich composite by an in-situ hydrothermal method, in which chemical vapor deposited 3D graphene acts as the high conductivity supporting framework, while the LiFePO4 nanoparticles are anchored onto the 3D graphene framework covered by graphene sheets. XRD and SEM results confirmed the formation of the 3DG/LFP/G sandwich composite. Cyclic Voltammetry curve of the sandwich composite shows sharper redox peaks and reduced voltage separation when compared to the reference electrodes, suggesting high specific capacity and good rate performance. Further charge/discharge measurements presented high capacity of 164 mAh g-1 at 0.2 C and 124 mAh g-1 at 10 C (75.7% of its initial capacity) for the sandwich composite, with capacity retention of 95.7% after 100 cycles, implying potential application in lithium ion battery at high rates. The EIS investigation suggests that both the electronic conductivity and the Li ion diffusion are promoted by the underlined 3D graphene framework, which is regarded as the reason for the enhanced electrochemical performance.

  8. Analysis of waste hierarchy in the European waste directive 2008/98/EC.

    PubMed

    Gharfalkar, Mangesh; Court, Richard; Campbell, Callum; Ali, Zulfiqur; Hillier, Graham

    2015-05-01

    Loss of recoverable resources in linear resource flow systems is likely to contribute to the depletion of natural resources and environmental degradation. The 'waste hierarchy' in the European Commission's latest Waste Framework Directive 2008/98/EC (WFD2008) makes recommendations on how to address this issue. The WFD2008 is analysed in this work for its adequacy in ensuring return of 'recoverable waste' as a 'resource' into the productive system. Despite the release of guidance documents by the DG Environment, DEFRA and WRAP UK on the interpretation of key provisions of the WFD2008, lack of clarity still exists around the WFD2008 'waste hierarchy'. There is also an overlap between measures such as 'prevention' and 'reduction', 'preparing for reuse' and 'reuse' and lack of clarity on why the measure of 'reuse' is included in the WFD2008 definition of 'prevention'. Finally, absence of the measures of 'recovery' and 'reuse' from the WFD2008 'waste hierarchy' reduces its effectiveness as a resource efficiency tool. Without clarity on the WFD2008 'waste hierarchy', it is challenging for decision makers to take direct action to address inefficiencies existing within their operations or supply chains. This paper proposes the development of an alternative 'hierarchy of resource use' and alternative 'definitions' that attempt to fill identified gaps in the WFD2008 and bring clarity to the key measures of waste prevention, reduction and recovery. This would help the key stakeholders in driving resource effectiveness, which in turn would assist in conservation of natural resources and prevention of environmental degradation.

  9. 78 FR 78923 - Comparability Determination for the European Union: Certain Entity-Level Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... request by the European Commission (``EC'') and the European Securities and Markets Authority (``ESMA..., the EC and ESMA (collectively, the ``applicant'') submitted a request that the Commission determine... the EU On May 7, 2013, the EC and ESMA submitted a request that the Commission assess...

  10. A Monte Carlo study of monoenergetic and polyenergetic normalized glandular dose (DgN) coefficients in mammography

    NASA Astrophysics Data System (ADS)

    Sarno, Antonio; Mettivier, Giovanni; Di Lillo, Francesca; Russo, Paolo

    2017-01-01

    We investigated the influence of model assumptions in GEANT4 Monte Carlo (MC) simulations for the calculation of monoenergetic and polyenergetic normalized glandular dose coefficients (DgN) in mammography, focussing on the effect of the skin thickness and composition, of the role of compression paddles and of the bremsstrahlung processes. We showed that selecting a skin thickness of 4 mm instead of 1.45 mm produced DgN values with deviations from 9% to 32% for x-ray spectra routinely adopted in mammography. Consideration of the bremsstrahlung radiation had a weak influence on monoenergetic DgN. Simulations (in the range 8-40 kVp) which included consideration of bremsstrahlung radiation, a skin thickness of 1.45 mm and a 2 mm thick compression paddles produced polyenergetic DgN coefficients up to 19% higher than corresponding literature data. Adding a 2 mm thick adipose layer between the skin layer and the radiosensitive portion of the breast produces polyenergetic DgN values up to 15% higher than those routinely adopted. These findings provide a quantitative estimate of the influence of model parameters on the calculation of the mean glandular dose in mammography.

  11. NEARTOWARN: A new EU-DG ECHO-supported project for the near-field tsunami early warning

    NASA Astrophysics Data System (ADS)

    Papadopoulos, G. A.

    2012-04-01

    The early warning for near-field (local) tsunamis, with travel times of no more than about 30 min. from the tsunami source to the closest coastal zones, is today a hot topic of great importance in the international effort to reduce the loss of human lives and to mitigate other tsunami risks. Particularly, in the Mediterranean region earthquakes, and more rarely volcanic eruptions and landslides, produce near-field tsunamis threatening nearly all the coastal zones but mainly those in the Hellenic Arc and Trench (South Peloponnese, Cyclades, Crete, Rhodes, SW Turkey), in the Corinth Gulf (Central Greece), in the Messina strait and the east Sicily (Italy) in the Ligurian Sea, the Algeria and the Balearic islands, in the west Mediterranean basin, and the Cyprus-Lebanon area in the easternmost Mediterranean. The North East Atlantic and Mediterranean Tsunami Warning System (NEAMTWS), which is under construction with the supervision of the Intergovernmental Oceanographic Commission, is oriented to issue warnings only in regional scales, that is for about 1 hour of tsunami propagation time. For near-field warning it is unrealistic to rely on a unique system for the entire basin. Instead, several local systems working on the basis of some joint principles but with local adjustements is the most promising solution. This is exactly the aim of the new project NEARToWARN (Near-field Tsunami Warning) which is supported by the EU DG-ECHO. Partnership includes the National Observatory of Athens (Coordinator, Greece), the University of Bologna (Italy), the University of Cyprus, the ACRI-ST (Sophia-Antipolis, France), the University of Cantabria (Spain) and the Municipility of Rhodes. The main concept is to develop a prototype local early tsunami warning system. To minimize the time for emergency in less than 30 sec, seismic alert devices (SED's) make the core component of the system. SED's are activated and send alerting signals as soon as a P-phase of seismic wave is detected in

  12. A Guide to Building Commissioning

    SciTech Connect

    Baechler, Michael C.

    2011-09-01

    Commissioning is the process of verifying that a building's heating, ventilation, and air conditioning (HVAC) and lighting systems perform correctly and efficiently. Without commissioning, system and equipment problems can result in higher than necessary utility bills and unexpected and costly equipment repairs. This report reviews the benefits of commissioning, why it is a requirement for Leadership in Energy and Environmental Design (LEED) certification, and why building codes are gradually adopting commissioning activities into code.

  13. Nuclear Regulatory Commission information digest

    SciTech Connect

    None,

    1990-03-01

    The Nuclear Regulatory Commission information digest provides summary information regarding the US Nuclear Regulatory Commission, its regulatory responsibilities, and areas licensed by the commission. This is an annual publication for the general use of the NRC Staff and is available to the public. The digest is divided into two parts: the first presents an overview of the US Nuclear Regulatory Commission and the second provides data on NRC commercial nuclear reactor licensees and commercial nuclear power reactors worldwide.

  14. Expedition 18 State Commission

    NASA Image and Video Library

    2008-10-10

    The State Commission gives the approval for launch of the Soyuz TMA-13 spacecraft carrying Expedition 18 Commander Michael Fincke, Flight Engineer Yuri V. Lonchakov and American spaceflight participant Richard Garriott to the International Space Station, Saturday, Oct. 11, 2008, in Baikonur, Kazakhstan. The three crew members are scheduled to launch Oct. 12 for a docking with the International Space Station on Oct. 14. Fincke and Lonchakov will spend six months on the station, while Garriott will return to Earth Oct. 24 with two of the Expedition 17 crew members currently on the International Space Station. Photo Credit: (NASA/Bill Ingalls)

  15. Expedition 18 State Commission

    NASA Image and Video Library

    2008-10-10

    Expedition 18 Flight Engineer Yuri V. Lonchakov, left, and Expedition 18 Commander Michael Fincke listen to the State Commission give the approval for launch of the Soyuz TMA-13 spacecraft, Saturday, Oct. 11, 2008, in Baikonur, Kazakhstan. Lonchakov, Fincke and American spaceflight participant Richard Garriott are scheduled to launch Oct. 12 and then to dock with the International Space Station on Oct. 14. Fincke and Lonchakov will spend six months on the station, while Garriott will return to Earth Oct. 24 with two of the Expedition 17 crew members currently on the International Space Station. Photo Credit: (NASA/Bill Ingalls)

  16. Expedition 18 State Commission

    NASA Image and Video Library

    2008-10-10

    A Russian flight surgeon, right, along with the quarantined prime and backup crews listen to the State Commission give the final approval for the launch of the Soyuz TMA-13 spacecraft, Saturday, Oct. 11, 2008 in Baikonur, Kazakhstan. Expedition 18 Commander Michael Fincke, Flight Engineer Yuri V. Lonchakov and American spaceflight participant Richard Garriott are scheduled to launch Oct. 12 and dock with the International Space Station on Oct. 14. Fincke and Lonchakov will spend six months on the station, while Garriott will return to Earth Oct. 24 with two of the Expedition 17 crew members currently on the International Space Station. Photo Credit: (NASA/Bill Ingalls)

  17. The SNS RFQ Commissioning

    SciTech Connect

    Ratti, A.; Ayers, J.; Doolittle, L.; DiGennaro, R.; Gough, R.A.; Hoff, M.; Keller, R.; MacGill, J.; Staples, J.; Thomae, R.; Virostek, S.; Yourd, R.; Aleksandrov, A.

    2002-08-16

    LBNL has built for the Spallation Neutron Source (SNS) project a 402.5 MHz RFQ that is designed to accelerate up to 60 mA H{sup -} from 65 keV to 2.5 MeV [1]. A one millisecond pulse length at 60 Hz provides a 6% duty factor. The RFQ has now been built, conditioned at full duty factor and tested with beam. This paper will present results from the final installation, tuning and beam commissioning. Beam measurements include acceleration and transport efficiencies and transverse emittances. The LEBT optics were tuned for best results. Performance testing of the RF power distribution is also discussed here.

  18. SNS Cryogenic Systems Commissioning

    NASA Astrophysics Data System (ADS)

    Hatfield, D.; Casagrande, F.; Campisi, I.; Gurd, P.; Howell, M.; Stout, D.; Strong, H.; Arenius, D.; Creel, J.; Dixon, K.; Ganni, V.; Knudsen, P.

    2006-04-01

    The Spallation Neutron Source (SNS) is under construction at Oak Ridge National Laboratory. The cold section of the Linac consists of 81 superconducting radio frequency cavities cooled to 2.1K by a 2400 watt cryogenic refrigeration system. The major cryogenic system components include warm helium compressors with associated oil removal and gas management, 4.5K cold box, 7000L liquid helium dewar, 2.1K cold box (consisting of 4 stages of cold compressors), gaseous helium storage, helium purification and gas impurity monitoring system, liquid nitrogen storage and the cryogenic distribution transfer line system. The overall system commissioning and future plans will be presented.

  19. Commission 31: Time

    NASA Astrophysics Data System (ADS)

    Defraigne, Pascale; Manchester, Richard; Matsakis, Demetrios; Petit, Gerard; Hosokawa, Mizuhiko; Leschiutta, Sigfrid; Zhai, Zao-Cheng

    2010-05-01

    Dr R. N. Manchester and Dr M. Hosokawa have been elected as, respectively, the new President and Vice-President of the Commission for the next term, 2009-2012. Concerning the Organizing Committee (OC) Members, we welcome as new members: Felicitas Aris (BIPM, France), Philip Tuckey (LNE-SYRTE, France), Vladimir Zharov (MSU, Russia), and Shougang Zhang (NTSC, China) and we acknowledge the outgoing members: Demetrios Matsakis, Gerard Petit, Mizuhiko Hosokawa, Sigfrid Leschiutta and Zao-Cheng Zhai. P. Defraigne remains on the OC as immediate Past-President.

  20. SNS Cryogenic Systems Commissioning

    SciTech Connect

    D. Hatfield; F. Casagrande; I. Campisi; P. Gurd; M. Howell; D. Stout; H. Strong; D. Arenius; J. Creel; K. Dixon; V. Ganni; and P. Knudsen

    2005-08-29

    The Spallation Neutron Source (SNS) is under construction at Oak Ridge National Laboratory. The cold section of the Linac consists of 81 superconducting radio frequency cavities cooled to 2.1K by a 2400 watt cryogenic refrigeration system. The major cryogenic system components include warm helium compressors with associated oil removal and gas management, 4.5K cold box, 7000L liquid helium dewar, 2.1K cold box (consisting of 4 stages of cold compressors), gaseous helium storage, helium purification and gas impurity monitoring system, liquid nitrogen storage and the cryogenic distribution transfer line system. The overall system commissioning and future plans will be presented.

  1. Attitudes of Europeans toward Age.

    ERIC Educational Resources Information Center

    Ageing International, 1993

    1993-01-01

    Two Commission of European Communities surveys of people over age 15 and of those over 60 demonstrated a widespread belief that older people deserve public support and services and face employment discrimination. Socioeconomic factors influenced older people's sense of security and life satisfaction. Positive intergenerational attitudes appeared.…

  2. Implications of 1992 for European Telecommunications.

    ERIC Educational Resources Information Center

    Muller, Jurgen

    This paper analyzes the effect of the unified single market of 1992 on European telecommunications. The major policy aspects of the European Economic Commission's Green Paper on "The Development of the Common Market for Telecommunications Services and Equipment" are highlighted, and the effects of these policies in the equipment market…

  3. Implications of 1992 for European Telecommunications.

    ERIC Educational Resources Information Center

    Muller, Jurgen

    This paper analyzes the effect of the unified single market of 1992 on European telecommunications. The major policy aspects of the European Economic Commission's Green Paper on "The Development of the Common Market for Telecommunications Services and Equipment" are highlighted, and the effects of these policies in the equipment market…

  4. INVESTIGATING PLANET FORMATION IN CIRCUMSTELLAR DISKS: CARMA OBSERVATIONS OF RY Tau AND DG Tau

    SciTech Connect

    Isella, Andrea; Carpenter, John M.; Sargent, Anneila I.

    2010-05-10

    We present CARMA observations of the thermal dust emission from the circumstellar disks around the young stars RY Tau and DG Tau at wavelengths of 1.3 mm and 2.8 mm. The angular resolution of the maps is as high as 0.''15, or 20 AU at the distance of the Taurus cloud, which is a factor of 2 higher than has been achieved to date at these wavelengths. The unprecedented detail of the resulting disk images enables us to address three important questions related to the formation of planets. (1) What is the radial distribution of the circumstellar dust? (2) Does the dust emission show any indication of gaps that might signify the presence of (proto-)planets? (3) Do the dust properties depend on the orbital radius? We find that modeling the disk surface density in terms of either a classical power law or the similarity solution for viscous disk evolution reproduces the observations well. Both models constrain the surface density between 15 and 50 AU to within 30% for a given dust opacity. Outside this range, the densities inferred from the two models differ by almost an order of magnitude. The 1.3 mm image from RY Tau shows two peaks separated by 0.''2 with a decline in the dust emission toward the stellar position, which is significant at about 2{sigma}-4{sigma}. For both RY Tau and DG Tau, the dust emission at radii larger than 15 AU displays no significant deviation from an unperturbed viscous disk model. In particular, no radial gaps in the dust distribution are detected. Under reasonable assumptions, we exclude the presence of planets more massive than 5 M{sub J} orbiting either star at distances between about 10 and 60 AU, unless such a planet is so young that there has been insufficient time to open a gap in the disk surface density. The radial variation of the dust opacity slope, {beta}, was investigated by comparing the 1.3 mm and 2.8 mm observations. We find mean values of {beta} of 0.5 and 0.7 for DG Tau and RY Tau, respectively. Variations in {beta} are

  5. Reduced Cerebral Oxygen Content in the DG and SVZ In Situ Promotes Neurogenesis in the Adult Rat Brain In Vivo.

    PubMed

    Zhang, Kuan; Zhou, Yanzhao; Zhao, Tong; Wu, Liying; Huang, Xin; Wu, Kuiwu; Xu, Lun; Li, Dahu; Liu, Shuhong; Zhao, Yongqi; Fan, Ming; Zhu, Lingling

    2015-01-01

    Neurogenesis in the adult brain occurs mainly within two neurogenic structures, the dentate gyrus (DG) of the hippocampus and the sub-ventricular zone (SVZ) of the forebrain. It has been reported that mild hypoxia promoted the proliferation of Neural Stem Cells (NSCs)in vitro. Our previous study further demonstrated that an external hypoxic environment stimulated neurogenesis in the adult rat brain in vivo. However, it remains unknown how external hypoxic environments affect the oxygen content in the brain and result in neurogenesis. Here we use an optical fiber luminescent oxygen sensor to detect the oxygen content in the adult rat brain in situ under normoxia and hypoxia. We found that the distribution of oxygen in cerebral regions is spatiotemporally heterogeneous. The Po2 values in the ventricles (45∼50 Torr) and DG (approximately 10 Torr) were much higher than those of other parts of the brain, such as the cortex and thalamus (approximately 2 Torr). Interestingly, our in vivo studies showed that an external hypoxic environment could change the intrinsic oxygen content in brain tissues, notably reducing oxygen levels in both the DG and SVZ, the major sites of adult neurogenesis. Furthermore, the hypoxic environment also increased the expression of HIF-1α and VEGF, two factors that have been reported to regulate neurogenesis, within the DG and SVZ. Thus, we have demonstrated that reducing the oxygen content of the external environment decreased Po2 levels in the DG and SVZ. This reduced oxygen level in the DG and SVZ might be the main mechanism triggering neurogenesis in the adult brain. More importantly, we speculate that varying oxygen levels may be the physiological basis of the regionally restricted neurogenesis in the adult brain.

  6. Genome-wide genetic screen identified the link between dG9a and epidermal growth factor receptor signaling pathway in vivo.

    PubMed

    Shimaji, Kouhei; Konishi, Takahiro; Yoshida, Hideki; Kimura, Hiroshi; Yamaguchi, Masamitsu

    2016-08-01

    G9a is one of the histone H3 Lys 9 (H3K9) specific methyltransferases first identified in mammals. Drosophila G9a (dG9a) has been reported to induce H3K9 dimethylation in vivo, and the target genes of dG9a were identified during embryonic and larval stages. Although dG9a is important for a variety of developmental processes, the link between dG9a and signaling pathways are not addressed yet. Here, by genome-wide genetic screen, taking advantage of the rough eye phenotype of flies that over-express dG9a in eye discs, we identified 16 genes that enhanced the rough eye phenotype induced by dG9a over-expression. These 16 genes included Star, anterior open, bereft and F-box and leucine-rich repeat protein 6 which are components of epidermal growth factor receptor (EGFR) signaling pathway. When dG9a over-expression was combined with mutation of Star, differentiation of R7 photoreceptors in eye imaginal discs as well as cone cells and pigment cells in pupal retinae was severely inhibited. Furthermore, the dG9a over-expression reduced the activated ERK signals in eye discs. These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Physical properties of the DG Tau jet on sub-arcsecond scales with HST/STIS

    NASA Astrophysics Data System (ADS)

    Bacciotti, Francesca; Maurri, Lorenzo; Podio, Linda; Eisloeffel, Jochen; Ray, Tom; Mundt, Reinhard; Locatelli, Ugo; Coffey, Deirdre

    2013-07-01

    Stellar jets are believed to play a key role in the formation of a new star, but the question of how they originate is still under debate. To get a better understanding of the launch process we derive the physical properties at the base of the blue-shifted jet from the Classical T Tauri star (CTTS) DG TAU, from spectra taken with the Hubble Space Telescope Imaging Spectrograph (HST/STIS) at optical wavelengths. The analysis provides information on the jet physics (kinematics, density, excitation) at 0.''1 angular resolution in two dimensions (along and across the jet), and as a function of velocity. Mass outflow and angular momentum rates can be estimated for different velocity components, giving indications on the validity of the proposed models for the jet generation.

  8. Thermal conductivity of diethylene glycol based magnesium-aluminum spinel (MgAl2O4-DG) nanofluids

    NASA Astrophysics Data System (ADS)

    Żyła, Gaweł; Fal, Jacek; Gizowska, Magdalena; Perkowski, Krzysztof

    2016-12-01

    The paper presents the results of measurements of the thermal conductivity of MgAl_2O_4 -DG nanofluids. The dependence of the thermal conductivity on concentration of nanoparticles in various temperatures from 293.15 to 338.15 K with 15 K step was examined. Experimental data was modeled with existing theoretical models describing the effects of the concentration of particles on the thermal conductivity of the suspension. It was presented that thermal conductivity of MgAl_2O_4 -DG nanofluids increases proportional to volume concentration of nanoparticles.

  9. Thermal conductivity of diethylene glycol based magnesium-aluminum spinel (MgAl2O4-DG) nanofluids

    NASA Astrophysics Data System (ADS)

    Żyła, Gaweł; Fal, Jacek; Gizowska, Magdalena; Perkowski, Krzysztof

    2017-06-01

    The paper presents the results of measurements of the thermal conductivity of MgAl_2O_4-DG nanofluids. The dependence of the thermal conductivity on concentration of nanoparticles in various temperatures from 293.15 to 338.15 K with 15 K step was examined. Experimental data was modeled with existing theoretical models describing the effects of the concentration of particles on the thermal conductivity of the suspension. It was presented that thermal conductivity of MgAl_2O_4-DG nanofluids increases proportional to volume concentration of nanoparticles.

  10. The OH rotational population and photodissociation of H{sub 2}O in DG Tauri

    SciTech Connect

    Carr, John S.; Najita, Joan R.

    2014-06-10

    We analyze the OH rotational emission in the Spitzer Space Telescope mid-infrared spectrum of the T Tauri star DG Tau. OH is observed in emission from upper level energies of 1900 K to 28,000 K. The rotational diagram cannot be fit with any single combination of temperature and column density and has slopes that correspond to excitation temperatures ranging from 200 K to 6000 K. The relative Λ-doublet population within each rotational level is not equal, showing that the OH population is not in thermal equilibrium. The symmetric Λ-doublet state is preferred in all rotational states, with an average of 0.5 for the population ratio of the anti-symmetric to symmetric state. We show that the population distribution of the high rotational lines and the Λ-doublet ratio are consistent with the formation of OH following the photo-dissociation of H{sub 2}O by FUV photons in the second absorption band of water (∼1150-1400 Å), which includes Lyα. Other processes, OH formation from either photo-dissociation of water in the first absorption band (1450-1900 Å) or the reaction O({sup 1} D) + H{sub 2}, or collisional excitation, cannot explain the observed emission in the high rotational states but could potentially contribute to the population of lower rotational levels. These results demonstrate that the photodissociation of water is active in DG Tau and support the idea that the hot rotational OH emission commonly observed in Classical T Tauri stars is due to the dissociation of H{sub 2}O by FUV radiation.

  11. DG TO FT - AUTOMATIC TRANSLATION OF DIGRAPH TO FAULT TREE MODELS

    NASA Technical Reports Server (NTRS)

    Iverson, D. L.

    1994-01-01

    Fault tree and digraph models are frequently used for system failure analysis. Both types of models represent a failure space view of the system using AND and OR nodes in a directed graph structure. Each model has its advantages. While digraphs can be derived in a fairly straightforward manner from system schematics and knowledge about component failure modes and system design, fault tree structure allows for fast processing using efficient techniques developed for tree data structures. The similarities between digraphs and fault trees permits the information encoded in the digraph to be translated into a logically equivalent fault tree. The DG TO FT translation tool will automatically translate digraph models, including those with loops or cycles, into fault tree models that have the same minimum cut set solutions as the input digraph. This tool could be useful, for example, if some parts of a system have been modeled using digraphs and others using fault trees. The digraphs could be translated and incorporated into the fault trees, allowing them to be analyzed using a number of powerful fault tree processing codes, such as cut set and quantitative solution codes. A cut set for a given node is a group of failure events that will cause the failure of the node. A minimum cut set for a node is any cut set that, if any of the failures in the set were to be removed, the occurrence of the other failures in the set will not cause the failure of the event represented by the node. Cut sets calculations can be used to find dependencies, weak links, and vital system components whose failures would cause serious systems failure. The DG TO FT translation system reads in a digraph with each node listed as a separate object in the input file. The user specifies a terminal node for the digraph that will be used as the top node of the resulting fault tree. A fault tree basic event node representing the failure of that digraph node is created and becomes a child of the terminal

  12. DG TO FT - AUTOMATIC TRANSLATION OF DIGRAPH TO FAULT TREE MODELS

    NASA Technical Reports Server (NTRS)

    Iverson, D. L.

    1994-01-01

    Fault tree and digraph models are frequently used for system failure analysis. Both types of models represent a failure space view of the system using AND and OR nodes in a directed graph structure. Each model has its advantages. While digraphs can be derived in a fairly straightforward manner from system schematics and knowledge about component failure modes and system design, fault tree structure allows for fast processing using efficient techniques developed for tree data structures. The similarities between digraphs and fault trees permits the information encoded in the digraph to be translated into a logically equivalent fault tree. The DG TO FT translation tool will automatically translate digraph models, including those with loops or cycles, into fault tree models that have the same minimum cut set solutions as the input digraph. This tool could be useful, for example, if some parts of a system have been modeled using digraphs and others using fault trees. The digraphs could be translated and incorporated into the fault trees, allowing them to be analyzed using a number of powerful fault tree processing codes, such as cut set and quantitative solution codes. A cut set for a given node is a group of failure events that will cause the failure of the node. A minimum cut set for a node is any cut set that, if any of the failures in the set were to be removed, the occurrence of the other failures in the set will not cause the failure of the event represented by the node. Cut sets calculations can be used to find dependencies, weak links, and vital system components whose failures would cause serious systems failure. The DG TO FT translation system reads in a digraph with each node listed as a separate object in the input file. The user specifies a terminal node for the digraph that will be used as the top node of the resulting fault tree. A fault tree basic event node representing the failure of that digraph node is created and becomes a child of the terminal

  13. Commission 10: Solar Activity

    NASA Astrophysics Data System (ADS)

    van Driel-Gesztelyi, Lidia; Schrijver, Carolus J.; Klimchuk, James A.; Charbonneau, Paul; Fletcher, Lyndsay; Hasan, S. Sirajul; Hudson, Hugh S.; Kusano, Kanya; Mandrini, Cristina H.; Peter, Hardi; Vršnak, Bojan; Yan, Yihua

    2012-04-01

    Commission 10 of the International Astronomical Union has more than 650 members who study a wide range of activity phenomena produced by our nearest star, the Sun. Solar activity is intrinsically related to solar magnetic fields and encompasses events from the smallest energy releases (nano- or even picoflares) to the largest eruptions in the Solar System, coronal mass ejections (CMEs), which propagate into the Heliosphere reaching the Earth and beyond. Solar activity is manifested in the appearance of sunspot groups or active regions, which are the principal sources of activity phenomena from the emergence of their magnetic flux through their dispersion and decay. The period 2008-2009 saw an unanticipated extended solar cycle minimum and unprecedentedly weak polar-cap and heliospheric field. Associated with that was the 2009 historical maximum in galactic cosmic rays flux since measurements begun in the middle of the 20th Century. Since then Cycle 24 has re-started solar activity producing some spectacular eruptions observed with a fleet of spacecraft and ground-based facilities. In the last triennium major advances in our knowledge and understanding of solar activity were due to continuing success of space missions as SOHO, Hinode, RHESSI and the twin STEREO spacecraft, further enriched by the breathtaking images of the solar atmosphere produced by the Solar Dynamic Observatory (SDO) launched on 11 February 2010 in the framework of NASA's Living with a Star program. In August 2012, at the time of the IAU General Assembly in Beijing when the mandate of this Commission ends, we will be in the unique position to have for the first time a full 3-D view of the Sun and solar activity phenomena provided by the twin STEREO missions about 120 degrees behind and ahead of Earth and other spacecraft around the Earth and ground-based observatories. These new observational insights are continuously posing new questions, inspiring and advancing theoretical analysis and

  14. Commission 45: Spectral Classification

    NASA Astrophysics Data System (ADS)

    Giridhar, Sunetra; Gray, Richard O.; Corbally, Christopher J.; Bailer-Jones, Coryn A. L.; Eyer, Laurent; Irwin, Michael J.; Kirkpatrick, J. Davy; Majewski, Steven; Minniti, Dante; Nordström, Birgitta

    This report gives an update of developments (since the last General Assembly at Prague) in the areas that are of relevance to the commission. In addition to numerous papers, a new monograph entitled Stellar Spectral Classification with Richard Gray and Chris Corbally as leading authors will be published by Princeton University Press as part of their Princeton Series in Astrophysics in April 2009. This book is an up-to-date and encyclopedic review of stellar spectral classification across the H-R diagram, including the traditional MK system in the blue-violet, recent extensions into the ultraviolet and infrared, the newly defined L-type and T-type spectral classes, as well as spectral classification of carbon stars, S-type stars, white dwarfs, novae, supernovae and Wolf-Rayet stars.

  15. Expedition 38 State Commission

    NASA Image and Video Library

    2013-11-06

    Expedition 38 Flight Engineer Koichi Wakata of the Japan Aerospace Exploration Agency, left, Soyuz Commander Mikhail Tyurin of Roscosmos, and, Flight Engineer Rick Mastracchio of NASA, right, are seen behind glass, while in quarantine, during the State Commission meeting held to approve the Soyuz launch of the crew for a six month mission aboard the International Space Station, Wednesday, Nov. 6, 2013 at the Cosmonaut Hotel in Baikonur, Kazakhstan. An Olympic torch that will be launched with the crew for a four-day visit to the station is seen on the left. The torch will return to Earth with another trio of station residents on Nov. 11 and will be part of the torch relay that ends with the lighting of the flame at the Fisht Stadium in Sochi, Russia Feb. 7 to mark the opening of the 2014 Winter Olympics. Photo Credit: (NASA/Bill Ingalls)

  16. Politics and Policies of Promoting Multilingualism in the European Union

    ERIC Educational Resources Information Center

    Romaine, Suzanne

    2013-01-01

    This article examines the politics of policies promoting multilingualism in the European Union (EU), specifically in light of the recently released European Union Civil Society Platform on Multilingualism. As the most far-reaching and ambitious policy document issued by the European Commission, the Platform warrants close scrutiny at a significant…

  17. Expert Groups in the Building of European Public Policy

    ERIC Educational Resources Information Center

    Robert, Cecile

    2012-01-01

    When it comes to building European public action, expertise is ubiquitous and polymorphic. This article intends to study the ways expertise is being used in the European Commission and the logics underlying its use. The massive use of expertise also has consequences for the practices and identities of actors with whom European institutions…

  18. Expert Groups in the Building of European Public Policy

    ERIC Educational Resources Information Center

    Robert, Cecile

    2012-01-01

    When it comes to building European public action, expertise is ubiquitous and polymorphic. This article intends to study the ways expertise is being used in the European Commission and the logics underlying its use. The massive use of expertise also has consequences for the practices and identities of actors with whom European institutions…

  19. The Organisation and Management of a European Educational Satellite System.

    ERIC Educational Resources Information Center

    Bates, A. W.

    This paper looks at the possible roles that the European Economic Community (EEC), as a pan-European quasi-governmental institution, might play in the management and organization of a European educational satellite system. The argument is made that there is a need for the EEC Commission to play an ongoing, regulatory role in this area. An…

  20. Politics and Policies of Promoting Multilingualism in the European Union

    ERIC Educational Resources Information Center

    Romaine, Suzanne

    2013-01-01

    This article examines the politics of policies promoting multilingualism in the European Union (EU), specifically in light of the recently released European Union Civil Society Platform on Multilingualism. As the most far-reaching and ambitious policy document issued by the European Commission, the Platform warrants close scrutiny at a significant…

  1. Model Commissioning Plan and Guide Specifications

    SciTech Connect

    1997-03-01

    The objectives of Model Commissioning Plan and Guide Specifications are to ensure that the design team applies commissioning concepts to the design and prepares commissioning specifications and a commission plan for inclusion in the bid construction documents.

  2. Developing a Method for Operative Diagnostics and Appraisal of Working Capacity of a Combustion Chamber DG-90

    NASA Astrophysics Data System (ADS)

    Razboinikov, A. A.; Vashchilin, V. V.

    2016-10-01

    In the paper the problematics of gas transport system, main factors of an urgency of the development are described. Stages of a proposed reconstruction of combustion chamber DG-90 are introduced. Basic elements of the elaborated method for appraisal of risks of an emergency situation occurrence are given. The expected efficiency from implementation of the produced method is described.

  3. Fermi/LAT detection of a transient gamma-ray flare in the vicinity of the binary star DG CVn

    NASA Astrophysics Data System (ADS)

    Loh, Alan; Corbel, Stéphane; Dubus, Guillaume

    2017-06-01

    Solar flares are regularly detected by the Large Area Telescope (LAT) on board the Fermi satellite, however no γ-ray emission from other stellar eruptions has ever been captured. The Swift detection in 2014 April of a powerful outburst originating from DG CVn, with associated optical and radio emissions, enticed us to search for possible 0.1-100 GeV emission from this flaring nearby binary star using the Fermi/LAT. No γ-ray emission is detected from DG CVn in 2014, but we report a significant γ-ray excess in 2012 November, at a position consistent with that of the binary. There are no reports of contemporary flaring at other wavelengths from DG CVn or any other source within the error circle of the γ-ray source. We argue that the γ-ray flare is more likely to have been associated with a background blazar than with DG CVn and identify a candidate for follow-up study.

  4. ZipperCream-CG and WhiteAcre-DG: Two Newly-released, Cream-type Southernpea Cultivars

    USDA-ARS?s Scientific Manuscript database

    Efforts to incorporate genes conditioning a persistent green seed phenotype into Zipper Cream and White Acre type backgrounds were completed with the official release of the new southernpea cultivars ZipperCream-CG and WhiteAcre-DG on 29 January 2008. ZipperCream-CG is a high yielding, large-seeded...

  5. Fermi/LAT detection of a transient gamma-ray flare in the vicinity of the binary star DG CVn

    DOE PAGES

    Loh, Alan; Corbel, Stéphane; Dubus, Guillaume

    2017-02-16

    Solar flares are regularly detected by the Large Area Telescope (LAT) on board the Fermi satellite, however no γ-ray emission from other stellar eruptions has ever been captured. The Swift detection in 2014 April of a powerful outburst originating from DG CVn, with associated optical and radio emissions, enticed us to search for possible 0.1–100 GeV emission from this flaring nearby binary star using the Fermi/LAT. No γ-ray emission is detected from DG CVn in 2014, but we report a significant γ-ray excess in 2012 November, at a position consistent with that of the binary. There are no reports ofmore » contemporary flaring at other wavelengths from DG CVn or any other source within the error circle of the γ-ray source. As a result, we argue that the γ-ray flare is more likely to have been associated with a background blazar than with DG CVn and identify a candidate for follow-up study.« less

  6. Q3DG: A computer program for strain-energy-release rates for delamination growth in composite laminates

    NASA Technical Reports Server (NTRS)

    Raju, I. S.

    1986-01-01

    The Q3DG is a computer program developed to perform a quasi-three-dimensional stress analysis for composite laminates which may contain delaminations. The laminates may be subjected to mechanical, thermal, and hygroscopic loads. The program uses the finite element method and models the laminates with eight-noded parabolic isoparametric elements. The program computes the strain-energy-release components and the total strain-energy release in all three modes for delamination growth. A rectangular mesh and data file generator, DATGEN, is included. The DATGEN program can be executed interactively and is user friendly. The documentation includes sections dealing with the Q3D analysis theory, derivation of element stiffness matrices and consistent load vectors for the parabolic element. Several sample problems with the input for Q3DG and output from the program are included. The capabilities of the DATGEN program are illustrated with examples of interactive sessions. A microfiche of all the examples is included. The Q3DG and DATGEN programs have been implemented on CYBER 170 class computers. Q3DG and DATGEN were developed at the Langley Research Center during the early eighties and documented in 1984 to 1985.

  7. Advances in soil erosion modelling through remote sensing data availability at European scale

    NASA Astrophysics Data System (ADS)

    Panagos, Panos; Karydas, Christos; Borrelli, Pasqualle; Ballabio, Cristiano; Meusburger, Katrin

    2014-08-01

    Under the European Union's Thematic Strategy for Soil Protection, the European Commission's Directorate-General for the Environment (DG Environment) has identified the mitigation of soil losses by erosion as a priority area. Policy makers call for an overall assessment of soil erosion in their geographical area of interest. They have asked that risk areas for soil erosion be mapped under present land use and climate conditions, and that appropriate measures be taken to control erosion within the legal and social context of natural resource management. Remote sensing data help to better assessment of factors that control erosion, such as vegetation coverage, slope length and slope angle. In this context, the data availability of remote sensing data during the past decade facilitates the more precise estimation of soil erosion risk. Following the principles of the Universal Soil Loss Equation (USLE), various options to calculate vegetative cover management (C-factor) have been investigated. The use of the CORINE Land Cover dataset in combination with lookup table values taken from the literature is presented as an option that has the advantage of a coherent input dataset but with the drawback of static input. Recent developments in the Copernicus programme have made detailed datasets available on land cover, leaf area index and base soil characteristics. These dynamic datasets allow for seasonal estimates of vegetation coverage, and their application in the G2 soil erosion model which represents a recent approach to the seasonal monitoring of soil erosion. The use of phenological datasets and the LUCAS land use/cover survey are proposed as auxiliary information in the selection of the best methodology.

  8. European Surveillance of Antimicrobial Consumption (ESAC): outpatient macrolide, lincosamide and streptogramin (MLS) use in Europe.

    PubMed

    Coenen, Samuel; Ferech, Matus; Malhotra-Kumar, Surbhi; Hendrickx, Erik; Suetens, Carl; Goossens, Herman

    2006-08-01

    Data on outpatient macrolide, lincosamide and streptogramin (MLS) use in Europe were collected from 25 countries within the ESAC project, funded by DG SANCO of the European Commission, using the WHO ATC/DDD methodology. For the period 1997-2003, data on outpatient use of systemic MLS aggregated at the level of the active substance were collected and expressed in DDD (WHO, version 2004) per 1000 inhabitants per day (DID). Macrolide use was analysed in detail, using a classification based on their mean plasma elimination half-life. Total outpatient MLS use in 2003 varied by a factor of 11 between the country with the highest (9.36 DID in Greece) and lowest (0.85 DID in Sweden) use. MLS use showed high seasonal variation. Short-, intermediate- and long-acting macrolides were used most in 6, 18 and 1 countries, respectively (mainly erythromycin, clarithromyin and azithromycin, respectively). Lincosamide use was observed in all countries (mainly clindamycin) and substantial streptogramin use only in France (pristinamycin). From 1997 to 2003, MLS use increased in 14 countries and was most pronounced in Greece (increase of >5 DID). Except for Sweden, a relative increase of intermediate- (mainly clarithromycin) and/or long-acting (mainly azithromycin) macrolide use was observed, at the expense of short-acting macrolide (mainly erythromycin) use. The observed differences between European countries in the levels of MLS use and the extreme seasonal variations in their use suggest that this class of antibiotics is prescribed inappropriately in many countries. The MLS classification developed here facilitates a more comprehensive description of macrolide use in Europe. These data (collected as part of ESAC) could promote investigations that lead to a deeper understanding of the link between macrolide use and resistance.

  9. DG TO FT - AUTOMATIC TRANSLATION OF DIGRAPH TO FAULT TREE MODELS

    NASA Technical Reports Server (NTRS)

    Iverson, D. L.

    1994-01-01

    Fault tree and digraph models are frequently used for system failure analysis. Both types of models represent a failure space view of the system using AND and OR nodes in a directed graph structure. Each model has its advantages. While digraphs can be derived in a fairly straightforward manner from system schematics and knowledge about component failure modes and system design, fault tree structure allows for fast processing using efficient techniques developed for tree data structures. The similarities between digraphs and fault trees permits the information encoded in the digraph to be translated into a logically equivalent fault tree. The DG TO FT translation tool will automatically translate digraph models, including those with loops or cycles, into fault tree models that have the same minimum cut set solutions as the input digraph. This tool could be useful, for example, if some parts of a system have been modeled using digraphs and others using fault trees. The digraphs could be translated and incorporated into the fault trees, allowing them to be analyzed using a number of powerful fault tree processing codes, such as cut set and quantitative solution codes. A cut set for a given node is a group of failure events that will cause the failure of the node. A minimum cut set for a node is any cut set that, if any of the failures in the set were to be removed, the occurrence of the other failures in the set will not cause the failure of the event represented by the node. Cut sets calculations can be used to find dependencies, weak links, and vital system components whose failures would cause serious systems failure. The DG TO FT translation system reads in a digraph with each node listed as a separate object in the input file. The user specifies a terminal node for the digraph that will be used as the top node of the resulting fault tree. A fault tree basic event node representing the failure of that digraph node is created and becomes a child of the terminal

  10. Commissioning of NSLS-II

    SciTech Connect

    Willeke, F.

    2015-05-03

    NSLS-II, the new 3rd generation light source at BNL was designed for a brightness of 1022 photons s-1mm-2mrad-2 (0.1%BW)-1. It was constructed between 2009 and 2014. The storage ring was commissioned in April 2014 which was followed by insertion device and beamline commissioning in the fall of 2014. All ambitious design parameters of the facility have already been achieved except for commissioning the full beam intensity of 500mA which requires more RF installation. This paper reports on the results of commissioning.

  11. Mean Glandular dose coefficients (DgN) for x-ray spectra used in contemporary breast imaging systems

    PubMed Central

    Nosratieh, Anita; Hernandez, Andrew; Shen, Sam Z.; Yaffe, Martin J.; Seibert, J. Anthony; Boone, John M.

    2015-01-01

    Purpose To develop tables of normalized glandular dose coefficients DgN for a range of anode–filter combinations and tube voltages used in contemporary breast imaging systems. Methods Previously published mono-energetic DgN values were used with various spectra to mathematically compute DgN coefficients. The tungsten anode spectra from TASMICS were used; Molybdenum and Rhodium anode-spectra were generated using MCNPx Monte Carlo code. The spectra were filtered with various thicknesses of Al, Rh, Mo or Cu. An initial HVL calculation was made using the anode and filter material. A range of the HVL values was produced with the addition of small thicknesses of polymethyl methacrylate (PMMA) as a surrogate for the breast compression paddle, to produce a range of HVL values at each tube voltage. Using a spectral weighting method, DgN coefficients for the generated spectra were calculated for breast glandular densities of 0%, 12.5%, 25%, 37.5%, 50% and 100% for a range of compressed breast thicknesses from 3 to 8 cm. Results Eleven tables of normalized glandular dose (DgN) coefficients were produced for the following anode/filter combinations: W + 50 μm Ag, W + 500 μm Al, W + 700 μm Al, W + 200 μm Cu, W + 300 μm Cu, W + 50 μm Rh, Mo + 400 μm Cu, Mo + 30 μm Mo, Mo + 25 μm Rh, Rh + 400 μm Cu and Rh + 25 μm Rh. Where possible, these results were compared to previously published DgN values and were found to be on average less than 2% different than previously reported values. Conclusion Over 200-pages of DgN coefficients were computed for modeled x-ray system spectra that are used in a number of new breast imaging applications. The reported values were found to be in excellent agreement when compared to published values. PMID:26348995

  12. European college of orthodontics: commission of affiliation and titularisation.

    PubMed

    Muller, Christine

    2012-06-01

    Date of birth: 28/4/1977; sex: female. A. (4/2006; 29 years). Tooth-arch discrepancy with bi-maxillary protrusion. Correction of bi-maxillary protrusion; avulsion of 15, 25, 35 and 45; fixed multi-bracket Incognito bi-maxillary appliance; mini-screw anchorage. B. POST-TREATMENT RECORDS DOCUMENTS: (9/2009; 32 years and 6 months). Permanent retainers using fixed upper and lower bonded wires. C. POST-RETENTION RECORDS: (7/2010; 33 years and 3 months). D. Reason for consultation: correction of crooked and "jutting" teeth. Extraoral examination: balanced facial levels; lateral view: predominant lower third; closed nasolabial angle; labial asymmetry with predominant lower lips. Endooral examination: young adult dentition; average dental status; large number of fillings; panorex confirms four devitalized teeth; good periodontal status; V-shaped upper arch with lingually ectopic 12 and 22; lower arch with slight incisor crowding; bi-lateral molar and canine Class I; crossbite of 12 and 22; 2-mm deepbite and 1-mm overjet. Copyright © 2012. Published by Elsevier Masson SAS.

  13. European College of Orthodontics: Commission on Membership and Tenure.

    PubMed

    Mujagic, Magali

    2012-09-01

    A. PRE-TREATMENT RECORDS: 1/6/2007; 11 year and 6 months. Class II, division 1 malocclusion associated with severe overbite; skeletal hypodivergency; complete set of teeth. Customized Incognito(®) bi-maxillary multi-bracket appliance with a series of ribbonwise archwires (dimension: .025 ×.018''); levelling; correction of the anteroposterior dimension using a Herbst appliance; finishings with .0182 ×.0182 βtitanium; retention. B. END OF TREATMENT RECORDS: 2/1/2010; 14 years and 11 months. Wires bonded from 13 to 23 and from 33 to 43 combined with an Andreasen activator at night; monitoring of possible evolution of third molars. C. END OF RETENTION RECORDS: 18/5/2011; 15 years and 4 months. Extra-oral examination: frontal view: slight predominance of the mid third, thin upper lip; lateral view: convexity, open nasolabial angle, retrusive chin and pronounced naso-labial fold. Patient consulted for the position of her anterior teeth which she thought to be "sticking out". Endo-oral examination: no crowding on either arch; Angle Class II relationships; pronounced anteroposterior overjet; pronounced overbite. Dental panorex: complete set of teeth; second molars unerupted. Copyright © 2012. Published by Elsevier Masson SAS.

  14. Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics: study protocol for a randomized controlled trial.

    PubMed

    Rosso-Fernández, Clara; Garnacho-Montero, José; Antonelli, Massimo; Dimopoulos, George; Cisneros, José Miguel

    2015-03-20

    Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries. Inappropriate empiric antimicrobial treatment is associated with increased mortality. In this context, the empirical treatment of choice for VAP is unknown. Colistin, is now the antimicrobial with greatest in vitro activity against MDR-GNB. The MagicBullet clinical trial is an investigator-driven clinical study, funded by the Seventh Framework Program of the European Commission. This is designed as a phase IV, randomized, controlled, open label, non-inferiority and international trial to assess the safety and efficacy of colistin versus meropenem in late onset VAP. The study is conducted in a total of 32 centers in three European countries (Spain, Italy and Greece) with specific high incidences of infections caused by MDR-GNB. Patients older than 18 years who develop VAP with both clinical and radiological signs, and are on mechanical ventilation for more than 96 hours, or less than 96 hours but with previous antibiotic treatment plus one week of hospitalization, are candidates for inclusion in the study. A total sample size of 496 patients will be randomized according to a severity clinical score (at the time of VAP diagnosis in a 1:1 ratio to receive either colistin 4.5 MU as a loading dose, followed by 3 MU every eight hours (experimental arm), or meropenem 2 g every eight hours (control arm), both combined with levofloxacin. Mortality from any cause at 28 days will be considered as the main outcome. Clinical and microbiological cure will be evaluated at 72 hours, eight days, the finalization of antibiotic treatment, and 28 days of follow-up. The efficacy evaluation will be performed in every patient who receives at least one study treatment drug, and with etiologic diagnosis of VAP, intention-to-treat population and per protocol analysis will be performed

  15. Multi-centre evaluation of pre-transfusional routine tests using 8-column format gel cards (DG Gel®).

    PubMed

    Taylor, J; Hyare, J; Stelfox, P; Williams, M; Lees, R; Maley, M

    2011-04-01

    Advances in immunohaematology laboratory practice to improve performance, cost-effectiveness and patient safety are desirable. To perform a multi-centre evaluation of the 8-column Grifols DG Gel(®) cards and reagent system to assess its performance, suitability and adaptability to the daily blood transfusion laboratory routine in the United Kingdom. A total of 4281 immunohematological analyses {1825 ABO/D grouping, 1921 antibody screening, 75 Rh phenotyping and K antigen determination, 361 antibody identification and 99 neonates [ABO/D and DAT (direct anti-globulin test)]} were performed on 2255 specimens. All cases were run in parallel with the reference method of each laboratory (DiaMed-ID(®) cards or conventional tube technique in some cases). Concordant results between Grifols DG Gel(®) system and the reference method were obtained in 97·7% of tests. For ABO grouping by the Grifols DG Gel(®) system, sensitivity was 99·95%, specificity was 99·96%, predictive positive value (PPV) was 99·89% and predictive negative value (PNV) was 99·98%. For D grouping, sensitivity was 99·78%, specificity was 100%, PPV was 100% and PNV was 99·78%. For antibody screening, sensitivity was 90·63%, specificity was 99·94%, PPV was 99·32% and PNV was 99·15%. Of the Rh subgroups and K types, results were 100% concordant. For antibody specificity detection, accuracy was 96·95% for Grifols DG Gel(®) system and 95·29% for DiaMed-ID(®) system. For the newborn tests, concordant results were obtained in 100% of ABO/D grouping and in 89·9% of DAT. The Grifols DG Gel(®) 8-column system is reliable and safe for routine tests performed in the immunohaematology laboratory. © 2010 The Authors. Transfusion Medicine © 2010 British Blood Transfusion Society.

  16. Commissioning a Hodoscope Detector

    NASA Astrophysics Data System (ADS)

    Lulis, Andrew; Merhi, Abdul; Frank, Nathan; Bazin, Daniel; Smith, Jenna; Thoennessen, Michael; MoNA Collaboration

    2013-10-01

    Experiments on neutron-rich nuclei are interesting since they test the limits of current nuclear theory. One method to populate neutron-rich nuclei is to utilize the (d,p) reaction in which the beam nucleus picks up a neutron from the target. This heavier nucleus immediately emits a neutron resulting in the same nucleus as the beam but with lower energy. One challenge is to discriminate decay products from unreacted beam particles by their difference in energy. A hodoscope was recently installed at the National Superconducting Cyclotron Laboratory (NSCL) as part of the MoNA-LISA-Sweeper setup to make experiments using a (d,p) reaction possible. The hodoscope is a 5 × 5 scintillator array consisting of CsI(Na) crystals with a resolution of better than 1%. This presentation will describe the recently commissioned detector and the results of the first data analysis using this device. Work supported by Augustana College and the National Science Foundation grant #0969173.

  17. Commissioning the SNO+ detector

    NASA Astrophysics Data System (ADS)

    Descamps, Freija; SNO+ Collaboration

    2016-09-01

    The SNO+ experiment is the successor to the Sudbury Neutrino Observatory (SNO), in which SNO's heavy water is replaced by approximately 780T of liquid scintillator (LAB). The combination of the 2km underground location, the use of ultra-clean materials and the high light-yield of the liquid scintillator means that a low background level and a low energy threshold can be achieved. This creates a new multipurpose neutrino detector with the potential to address a diverse set of physics goals, including the detection of reactor, solar, geo- and supernova neutrinos. A main physics goal of SNO+ is the search for neutrinoless double beta decay. By loading the liquid scintillator with 0.5% of natural Tellurium, resulting in about 1300kg of 130Te (isotopic abundance is slightly over 34%), a competitive sensitivity to the effective neutrino mass can be reached. This talk will present the status of the SNO+ detector, specifically the results and status of the detector commissioning with water.

  18. ALICE TPC commissioning results

    NASA Astrophysics Data System (ADS)

    Larsen, D. T.; Alice Tpc Collaboration

    2010-05-01

    ALICE is a dedicated heavy-ion experiment at CERN LHC aiming to study the properties of the quark-gluon plasma. A lead-lead collision might produce several 10 00 new particles. Detailed study of the event requires precise measurements of the particle tracks. A 90 m3 Time Projection Chamber (TPC) with more than 500 000 read-out pads was built as the main central barrel tracker. Collisions can be recorded at a rate of up to about 1 kHz. The front-end electronics, designed from FPGAs and custom ASICs, performs shaping, amplification, digitisation and digital filtering of the signals. The data are forwarded to DAQ via 216 1.25 Gb/s fibre-optical links. Configuration, control and monitoring is done by an embedded Linux system on the front-end electronics. Before production runs with beam, extensive commissioning using tracks from cosmics and from the laser system as well as clusters from radioactive krypton gas is needed. Extensive results have been obtained with respect to the performance of the TPC including its sub-systems.

  19. National Knowledge Commission

    NASA Astrophysics Data System (ADS)

    Pitroda, Sam

    2007-04-01

    India's National Knowledge Commission (NKC) established by the prime minister is focused on building institutions and infrastructure in Education, Science and Technology, Innovation etc. to meet the challenges of the knowledge economy in the 21st century and increase India's competitive advantage in the global market. India today stands poised to reap the benefits of a rapidly growing economy and a major demographic advantage, with 550 million young people below the age of 25 years, the largest in the world. The NKC is focused on five critical areas of knowledge related to access, concepts, creation, applications and services. This includes a variety of subject areas such as language, translations, libraries, networks, portals, affirmative action, distance learning, intellectual property, Entrepreneurship, application in Agriculture, health, small and medium scale industries, e-governance etc. One of the keys to this effort is to build a national broadband gigabit of networks of 500 nodes to connect universities, Libraries, Laboratories, Hospitals, Agriculture institutions etc. to share resources and collaborate on multidisciplinary activities. This presentation will introduce the NKC, discuss methodology, subject areas, specific recommendation and outline a plan to build knowledge networks and specifics on network architecture, applications, and utilities.

  20. Commissioning the SNO+ Detector

    NASA Astrophysics Data System (ADS)

    Caden, E.; Coulter, I.; SNO+ Collaboration

    2017-09-01

    SNO+ is a multipurpose liquid scintillator neutrino experiment based at SNOLAB in Sudbury, Ontario, Canada. The experiment’s main physics goal is a search for neutrinoless double beta decay in Tellurium-130, but SNO+ will also study low energy solar neutrinos, geo- and reactor-antineutrinos, among other topics. We are reusing much of the hardware from the original SNO experiment, but significant work has taken place to transform the heavy water detector into a liquid scintillator detector. We present upgrades and improvements to the read-out electronics and trigger system to handle the higher data rates expected by a scintillator experiment. We show the successful installation and testing of a hold-down rope net for the acrylic vessel to counter-act the buoyancy of organic liquid scintillator. We also describe the new scintillator process plant and cover gas systems that have been constructed to achieve the purification necessary to meet our physics goals. We are currently commissioning the experiment with ultra-pure water in preparation for filling with scintillator in early 2017 and present the current status of this work.

  1. LIGO Detector Commissioning

    NASA Astrophysics Data System (ADS)

    Raab, Frederick

    2003-04-01

    The initial LIGO interferometer design was based on more than 20 years of experience with test interferometers, but the increase in scale, new operating environments and extreme technical requirements presented challenges for commissioning. Detector installation began in 1998 with injection optics at Hanford, WA. By 1999, light was resonating in a single 2-km Fabry-Perot arm cavity. Subsequent engineering runs tested stability and analyzed environmental influences, particularly the earth tides and the microseism. By October 2000, the first lock of a kilometer-scale, power recycled Fabry-Perot-Michelson interferometer was obtained, using an automated system to analyze optical signals and reconfigure control loops as the mirrors are drawn into position. The many control loops that minimize length and angle fluctuations of the mirrors relative to the laser light were tuned and noise sources were identified and reduced iteratively as sensitivity improved by several orders of magnitude. Following installation of the last LIGO mirror in 2001, engineering run 7 provided the first triple-coincidence operation of LIGO's interferometers at Hanford and Livingston, LA in early 2002. Clear signals of mirrors recoiling from the Brownian motion of the suspension-wire violin modes first emerged from the noise during science run 1 in September 2002, at approximately the expected amplitude. Detector robustness has steadily improved and uninterrupted locking on a dark fringe for more than a day has been achieved. The support of the US National Science Foundation under Cooperative Agreement No. PHY-0107417 is gratefully acknowledged.

  2. Reflections on the Gordon Commission

    ERIC Educational Resources Information Center

    Haertel, Edward

    2014-01-01

    Background:This brief reflection on the work of the Gordon Commission calls out significant themes and implications found in the various papers authored by the commissioners and other scholars, especially those included in this special issue of Teachers College Record. Purpose: The forward-looking vision of the Gordon Commission is contrasted with…

  3. Vermont Technical Education Commission Report.

    ERIC Educational Resources Information Center

    Vermont State Technical Education Commission, Montpelier.

    A 1968 New England Regional Commission grant to the Vermont Department of Administration financed a feasibility study for a technical college at the postsecondary level. The commission undertook two specific studies: an examination of ultimate career destinations of Vermont secondary students and a survey of Vermont industry to determine immediate…

  4. Molecular dynamics studies of axis bending in d(G5-(GA4T4C)2-C5) and d(G5-(GT4A4C)2-C5): effects of sequence polarity on DNA curvature.

    PubMed

    Sprous, D; Young, M A; Beveridge, D L

    1999-01-29

    Gel retardation studies and other experiments indicate that DNA sequences containing the d(GA4T4C)n motif are curved, whereas those of identical composition but with a reverse sequence polarity, the d(GT4A4C)n motif, are straight. Hydroxyl radical cleavage experiments show that d(GA4T4C)n shows a unique signature, whereas d(GT4A4C)n behaves normally. To explain these results at a molecular level, molecular dynamics (MD) simulations were performed on the DNA duplexes d(G5-(GA4T4C)2-C5) and d(G5-(GT4A4C)2-C5) to 3.0 and 2.5 ns, respectively. The MD simulations are based on the Cornell force field implemented in the AMBER 4.1 modeling package and performed in a neutral solution of anionic DNA with K+, Cl- and Mg2+ at concentrations roughly comparable to a ligase buffer. Long range interactions were treated by the particle mesh Ewald method. Analysis of the results shows that the calculated dynamical structure of d(G5-(GA4T4C)2-C5) exhibits strong gross curvature, consistent with the observed behavior. The most significant locus of curvature in the MD structure is found at the central C15-G16 step, with an average roll angle of 12.8(+/-6.40)deg. The d(G5-(GT4A4C)2-C5) MD structure exhibited significantly less gross curvature. Analysis of results indicates that the reduction in gross curvature in the d(G5-(GT4A4C)2-C5) trajectory originates from the effect of the T10-A11 and T20-A21 steps, which showed average roll angles of 12.5(+/-5)deg. These three steps, T10-A11, C15-G16 and T20-A21, are half-helix turns away from one another, and their contributions to concerted bending cancel out. The A-tracts in the MD structure are essentially straight. The dynamical structure of d(G5-(GA4T4C)2-C5) exhibited minor groove deformation comprised of expansion at the 5' end of A-tracts and progressive narrowing towards the 3' end, consistent with and elaborating the interpretation of hydroxyl radical chemical probing results. Copyright 1999 Academic Press.

  5. Purification and characterization of chitinases from Paecilomyces variotii DG-3 parasitizing on Meloidogyne incognita eggs.

    PubMed

    Nguyen, Van-Nam; Oh, In-Jae; Kim, Young-Ju; Kim, Kil-Yong; Kim, Young-Cheol; Park, Ro-Dong

    2009-02-01

    Two extracellular chitinases were purified from Paecilomyces variotii DG-3, a chitinase producer and a nematode egg-parasitic fungus, to homogeneity by DEAE Sephadex A-50 and Sephadex G-100 chromatography. The purified enzymes were a monomer with an apparent molecular mass of 32 kDa (Chi32) and 46 kDa (Chi46), respectively, and showed chitinase activity bands with 0.01% glycol chitin as a substrate after SDS-PAGE. The first 20 and 15 N-terminal amino acid sequences of Chi32 and Chi46 were determined to be Asp-Pro-Typ-Gln-Thr-Asn-Val-Val-Tyr-Thr-Gly-Gln-Asp-Phe-Val-Ser-Pro-Asp-Leu-Phe and Asp-Ala-X-X-Tyr-Arg-Ser-Val-Ala-Tyr-Phe-Val-Asn-Trp-Ala, respectively. Optimal temperature and pH of the Chi32 and Chi46 were found to be both 60 degrees C, and 2.5 and 3.0, respectively. Chi32 was almost inhibited by metal ions Ag(+) and Hg(2+) while Chi46 by Hg(2+) and Pb(2+) at a 10 mM concentration but both enzymes were enhanced by 1 mM concentration of Co(2+). On analyzing the hydrolyzates of chitin oligomers [(GlcNAc)( n ), n = 2-6)], it was considered that Chi32 degraded chitin oligomers as an exo-type chitinase while Chi46 as an endo-type chitinase.

  6. Analysis of high-k spacer on symmetric underlap DG-MOSFET with Gate Stack architecture

    NASA Astrophysics Data System (ADS)

    Das, Rahul; Chakraborty, Shramana; Dasgupta, Arpan; Dutta, Arka; Kundu, Atanu; Sarkar, Chandan K.

    2016-09-01

    This paper shows the systematic study of underlap double gate (U-DG) NMOSFETs with Gate Stack (GS) under the influence of high-k spacers. In highly scaled devices, underlap is used at the Source and Drain side so as to reduce the short channel effects (SCE's), however, it significantly reduces the on current due to the increased channel resistance. To overcome these drawbacks, the use of high-k spacers is projected as one of the remedies. In this paper, the analog performance of the devices is studied on the basis of parameters like transconductance (gm), transconductance generation factor (gm/Id) and intrinsic gain (gmro). The RF performance is analyzed on the merits of intrinsic capacitance (Cgd, Cgs), resistance (Rgd, Rgs), transport delay (τm), inductance (Lsd), cutoff frequency (fT), and the maximum frequency of oscillation (fmax). The circuit performance of the devices are studied by implementing the device as the driver MOSFET in a Single Stage Common Source Amplifier. The Gain Bandwidth Product (GBW) has been analyzed from the frequency response of the circuit.

  7. Effects of hexagonal boron nitride on dry compression mixture of Avicel DG and Starch 1500.

    PubMed

    Uğurlu, Timuçin; Halaçoğlu, Mekin Doğa

    2016-01-01

    The objective of this study was to investigate the lubrication properties of hexagonal boron nitride (HBN) on a (1:1) binary mixture of Avicel DG and Starch 1500 after using the dry granulation-slugging method and compare it with conventional lubricants, such as magnesium stearate (MGST), glyceryl behenate (COMP) and stearic acid (STAC). MGST is one of the most commonly used lubricants in the pharmaceutical industry. However, it has several adverse effects on tablet properties. In our current study, we employed various methods to eradicate the work hardening phenomenon in dry granulation, and used HBN as a new lubricant to overcome the adverse effects of other lubricants on tablet properties. HBN was found to be as effective as MGST and did not show any significant adverse effects on the crushing strength or work hardening. From the scanning electron microscope (SEM) images, it was concluded that HBN distributed better than MGST. As well as showing better distribution, HBN's effect on disintegration was the least pronounced. Semi-quantitative weight percent distribution of B and N elements in the tablets was obtained using EDS (energy dispersive spectroscopy). Based on atomic force microscope (AFM) surface roughness images, formulations prepared with 1% HBN showed better plastic character than those prepared with MGST.

  8. Regulation of iron transport related genes by boron in the marine bacterium Marinobacter algicola DG893.

    PubMed

    Romano, Ariel; Trimble, Lyndsay; Hobusch, Ashtian R; Schroeder, Kristine J; Amin, Shady A; Hartnett, Andrej D; Barker, Ryan A; Crumbliss, Alvin L; Carrano, Carl J

    2013-08-01

    While there has been extensive interest in the use of boron isotope ratios as a surrogate of pH in paleoclimate studies in the context of climate change-related questions, the high (0.4 mM) concentration and the depth-independent (conservative or non-nutrient-like) concentration profile of this element have led to boron being neglected as a potentially biologically relevant element in the modern ocean. Here we report that boron affects the expression of a number of protein and genes in the "algal-associated" Gram-negative marine bacterium Marinobacter algicola DG893. Most intriguingly, a number of these proteins and genes are related to iron uptake. In a recent separate publication we have shown that boron regulates one such iron transport related protein, i.e. the periplasmic iron binding protein FbpA via a direct interaction of the metalloid with this protein. Here we show that a number of other iron uptake related genes are also affected by boron but in the opposite way i.e. they are up-regulated. We propose that the differential effect of boron on FbpA expression relative to other iron transport related genes is a result of an interaction between boron and the global iron regulatory protein Fur.

  9. A hierarchical uniformly high order DG-IMEX scheme for the 1D BGK equation

    NASA Astrophysics Data System (ADS)

    Xiong, Tao; Qiu, Jing-Mei

    2017-05-01

    A class of high order nodal discontinuous Galerkin implicit-explicit (DG-IMEX) schemes with asymptotic preserving (AP) property has been developed for the one-dimensional (1D) BGK equation in Xiong et al. (2015) [40], based on a micro-macro reformulation. The schemes are globally stiffly accurate and asymptotically consistent, and as the Knudsen number becomes small or goes to zero, they recover first the compressible Navier-Stokes (CNS) and then the Euler limit. Motivated by the recent work of Filbet and Rey (2015) [27] and the references therein, in this paper, we propose a hierarchical high order AP method, namely kinetic, CNS and Euler solvers are automatically applied in regions where their corresponding models are appropriate. The numerical solvers for different regimes are coupled naturally by interface conditions. To the best of our knowledge, the resulting scheme is the very first hierarchical one being proposed in the literature, that enjoys AP property as well as uniform high order accuracy. Numerical experiments demonstrate the efficiency and effectiveness of the proposed approach. As time evolves, three different regimes are dynamically identified and naturally coupled, leading to significant CPU time savings (more than 80% for some of our test problems).

  10. Results and limits in the 1-D analytical modeling for the asymmetric DG SOI MOSFET

    NASA Astrophysics Data System (ADS)

    Cobianu, O.; Glesner, M.

    2008-05-01

    This paper presents the results and the limits of 1-D analytical modeling of electrostatic potential in the low-doped p type silicon body of the asymmetric n-channel DG SOI MOSFET, where the contribution to the asymmetry comes only from p- and n-type doping of polysilicon used as the gate electrodes. Solving Poisson's equation with boundary conditions based on the continuity of normal electrical displacement at interfaces and the presence of a minimum electrostatic potential by using the Matlab code we have obtained a minimum potential with a slow variation in the central zone of silicon with the value pinned around 0.46 V, where the applied VGS voltage varies from 0.45 V to 0.95 V. The paper states clearly the validity domain of the analytical solution and the important effect of the localization of the minimum electrostatic potential value on the potential variation at interfaces as a function of the applied VGS voltage.

  11. Cool, warm and hot outflows from CTTS: The FUV view of DG Tau

    NASA Astrophysics Data System (ADS)

    Schneider, P. C.; Eislöffel, J.; Güdel, M.; Günther, H. M.; Herczeg, G.; Robrade, J.; Schmitt, J. H. M. M.

    2014-01-01

    Classical T Tauri stars (CTTSs) drive strong outflows with temperatures from about 103 K up to a few 106 K. These outflows regulate the angular momentum balance and are therefore tightly related to the accretion process. However, the outflow driving and heating mechanisms are not well understood. We present new HST data of the "prototypical" jet-driving CTTS DG Tau tracing the low-temperature outflow with fluorescently excited far-UV molecular hydrogen emission and the high-temperature part with C IV emission. We find that the spatial distribution of the low-temperature plasma is V-shaped consistent with molecular disk-wind models. Low-velocity shocks (vshock ~ 30 km s-1) are probably the pumping source for the FUV H2 lines. The hot plasma (T > 105 K) is located close to the jet axis at a distance of 40 AU from the driving source and spatially offset from standard (optical) jet-tracers like [S II] or [O I]. It does not show any hints for proper-motion contrasting typical jet properties. The high-temperature plasma is unlikely caused by a hot stellar wind and we propose that the stationary heating is caused by internal shocks or magnetic reconnection.

  12. Cool, warm and hot outflows from CTTS: The FUV view of DG Tau

    NASA Astrophysics Data System (ADS)

    Schneider, Christian; Eisloeffel, Jochen; Guedel, Manuel; Guenther, Moritz; Herczeg, Greg; Robrade, Jan; Schmitt, Juergen

    2013-07-01

    Classical T Tauri stars drive strong outflows with temperatures from about 1e3 K up to a few 1e6 K. These outflows regulate the angular momentum balance and are therefore tightly related to the accretion process. However, the outflow driving and heating mechanisms are not well understood. We present new HST data of the prototypical jet-driving CTTS DG Tau tracing the low-temperature outflow with far-UV molecular hydrogen emission and the high-temperature part with C IV emission. We find that the low-temperature part shows a pronounced V-shape consistent with molecular disk-wind models. Low-velocity shocks are probably the pumping source for the FUV H2 lines. The hot plasma (T>1e5 K) is located close to the jet axis at a distance of 40 AU from the driving source and spatially offset from usual (optical) jet-tracers like [S II] or [O I]. It does not show any hints for proper-motion contrasting typical jet properties. The high-temperature plasma is unlikely to be caused by a hot stellar wind and we propose that the stationary heating is due to internal shocks or magnetic reconnection.

  13. European strategies for mental health.

    PubMed

    Di Fiandra, Teresa

    2009-01-01

    The most recent developments of strategies and policies in the mental health field in Europe are related to the World Health Organization (WHO) Declaration and Action Plan on Mental Health signed by all the Ministers of Health of all Member States in the European Region (2005). The Action Plan proposes ways and means of developing comprehensive mental health policies, listing 12 areas in which challenges are indicated and detailed actions are required. Afterwards the Green Paper on Mental Health has been launched by the European Commission for the definition of an European strategy. The more precise European Pact for Mental Health and Well-being has been presented in 2008. Many other international bodies (OECD, Council of Europe, etc.) have actively worked to stress the mental health issue. All are clearly referring to the Italian model, started 30 years ago.

  14. Application of USNRC NUREG/CR-6661 and draft DG-1108 to evolutionary and advanced reactor designs

    SciTech Connect

    Chang 'Apollo', Chen

    2006-07-01

    For the seismic design of evolutionary and advanced nuclear reactor power plants, there are definite financial advantages in the application of USNRC NUREG/CR-6661 and draft Regulatory Guide DG-1108. NUREG/CR-6661, 'Benchmark Program for the Evaluation of Methods to Analyze Non-Classically Damped Coupled Systems', was by Brookhaven National Laboratory (BNL) for the USNRC, and Draft Regulatory Guide DG-1108 is the proposed revision to the current Regulatory Guide (RG) 1.92, Revision 1, 'Combining Modal Responses and Spatial Components in Seismic Response Analysis'. The draft Regulatory Guide DG-1108 is available at http://members.cox.net/apolloconsulting, which also provides a link to the USNRC ADAMS site to search for NUREG/CR-6661 in text file or image file. The draft Regulatory Guide DG-1108 removes unnecessary conservatism in the modal combinations for closely spaced modes in seismic response spectrum analysis. Its application will be very helpful in coupled seismic analysis for structures and heavy equipment to reduce seismic responses and in piping system seismic design. In the NUREG/CR-6661 benchmark program, which investigated coupled seismic analysis of structures and equipment or piping systems with different damping values, three of the four participants applied the complex mode solution method to handle different damping values for structures, equipment, and piping systems. The fourth participant applied the classical normal mode method with equivalent weighted damping values to handle differences in structural, equipment, and piping system damping values. Coupled analysis will reduce the equipment responses when equipment, or piping system and structure are in or close to resonance. However, this reduction in responses occurs only if the realistic DG-1108 modal response combination method is applied, because closely spaced modes will be produced when structure and equipment or piping systems are in or close to resonance. Otherwise, the conservatism in

  15. Commission 31: Time

    NASA Astrophysics Data System (ADS)

    Matsakis, Demetrios; Defraigne, Pascale; Hosokawa, M.; Leschiutta, S.; Petit, G.; Zhai, Z.-C.

    2007-03-01

    The most intensely discussed and controversial issue in time keeping has been the proposal before the International Telecommunications Union (ITU) to redefine Coordinated Universal Time (UTC) so as to replace leap seconds by leap hours. Should this proposal be adopted, the practice of inserting leap seconds would cease after a specific date. Should the Earth's rotation continue to de-accelerate at its historical rate, the next discontinuity in UTC would be an hour inserted several centuries from now. Advocates of this proposal cite the need to synchronize satellite and other systems, such as GPS, Galileo, and GLONASS, which did not exist and were not envisioned when the current system was adopted. They note that leap second insertions can be and have been incorrectly implemented or accounted for. Such errors have to date had localized impact, but they could cause serious mishaps involving loss of life. For example, some GPS receivers have been known to fail simply because there was no leap second after a long enough interval, other GPS receivers failed because the leap second information was broadcast more than three months in advance, and some commercial software used for internet time-transfer Network Time Protocol (NTP) could either discard all data received after a leap second or interpret it as a frequency change. The ambiguity associated with the extra second could also disrupt financial accounting and certain forms of encryption. Those opposed to the proposal question the need for a change, and also point out the costs of adjusting to the proposed change and its inconvenience to amateur astronomers and others who rely upon astronomical calculations published in advance. Reports have been circulated that the cost of checking and correcting software to accommodate the new definition of UTC would be many millions of dollars for some systems. In October 2005 American Astronomical Society asked the ITU for a year's time to study the issue. This commission has

  16. Twentieth anniversary of the European Union health mandate: taking stock of perceived achievements, failures and missed opportunities – a qualitative study

    PubMed Central

    2013-01-01

    Background The European Union (EU) health mandate was initially defined in the Maastricht Treaty in 1992. The twentieth anniversary of the Treaty offers a unique opportunity to take stock of EU health actions by giving an overview of influential public health related EU-level policy outputs and a summary of policy outputs or actions perceived as an achievement, a failure or a missed opportunity. Methods Semi-structured expert interviews (N = 20) were conducted focusing on EU-level actions that were relevant for health. Respondents were asked to name EU policies or actions that they perceived as an achievement, a failure or a missed opportunity. A directed content analysis approach was used to identify expert perceptions on achievements, failures and missed opportunities in the interviews. Additionally, a nominal group technique was applied to identify influential and public health relevant EU-level policy outputs. Results The ranking of influential policy outputs resulted in top positions of adjudications and legislations, agencies, European Commission (EC) programmes and strategies, official networks, cooperative structures and exchange efforts, the work on health determinants and uptake of scientific knowledge. The assessment of EU health policies as being an achievement, a failure or a missed opportunity was often characterized by diverging respondent views. Recurring topics that emerged were the Directorate General for Health and Consumers (DG SANCO), EU agencies, life style factors, internal market provisions as well as the EU Directive on patients’ rights in cross-border healthcare. Among these recurring topics, expert perceptions on the establishment of DG SANCO, EU public health agencies, and successes in tobacco control were dominated by aspects of achievements. The implementation status of the Health in All Policy approach was perceived as a missed opportunity. Conclusions When comparing the emerging themes from the interviews conducted with the

  17. Nanoscale T-shaped Double Gate DG MOSFET: Numerical Investigation for Analog/RF and Digital Performance

    NASA Astrophysics Data System (ADS)

    Kumari, Vandana; Ilango, Aravindan; Saxena, Manoj; Gupta, Mridula

    2016-01-01

    The present work demonstrates the investigation of T-shaped Double Gate MOSFET for analog and digital performance. The 2D analytical modeling scheme is presented using Evanescent Mode Analysis (EMA). The applicability of the proposed model has been verified using ATLAS 3D device simulation. The device exploits peaks in the electric field inside the channel (due to T-shaped gate) for better carrier transport efficiency and subsequently higher drain current and trans-conductance. The impact of dielectric constant of the void layer (due to T-shaped gate) on the electrostatic of the device has been investigated using basic electrical parameters such as: sub-threshold slope, Drain Induced Barrier Lowering DIBL, device gain and Ion/Ioff ratio. The comparative study between T-shaped DG with the conventional DG MOSFET is also presented.

  18. 18 CFR 375.101 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false The Commission. 375.101... OF ENERGY REVISED GENERAL RULES THE COMMISSION General Provisions § 375.101 The Commission. (a) Establishment. The Federal Energy Regulatory Commission is an independent regulatory commission within the...

  19. 47 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false The Commission. 0.1 Section 0.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Organization General § 0.1 The Commission. The Federal Communications Commission is composed of five (5) members who are appointed by the...

  20. 47 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false The Commission. 0.1 Section 0.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Organization General § 0.1 The Commission. The Federal Communications Commission is composed of five (5) members who are appointed by the...

  1. 18 CFR 375.101 - The Commission.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false The Commission. 375.101... OF ENERGY REVISED GENERAL RULES THE COMMISSION General Provisions § 375.101 The Commission. (a) Establishment. The Federal Energy Regulatory Commission is an independent regulatory commission within the...

  2. 47 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false The Commission. 0.1 Section 0.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Organization General § 0.1 The Commission. The Federal Communications Commission is composed of five (5) members who are appointed by the...

  3. 11 CFR 9002.3 - Commission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Commission. 9002.3 Section 9002.3 Federal Elections FEDERAL ELECTION COMMISSION PRESIDENTIAL ELECTION CAMPAIGN FUND: GENERAL ELECTION FINANCING DEFINITIONS § 9002.3 Commission. Commission means the Federal Election Commission, 999 E Street, NW...

  4. 11 CFR 9032.3 - Commission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Commission. 9032.3 Section 9032.3 Federal Elections FEDERAL ELECTION COMMISSION PRESIDENTIAL ELECTION CAMPAIGN FUND: PRESIDENTIAL PRIMARY MATCHING FUND DEFINITIONS § 9032.3 Commission. Commission means the Federal Election Commission, 999 E Street NW...

  5. 47 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false The Commission. 0.1 Section 0.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Organization General § 0.1 The Commission. The Federal Communications Commission is composed of five (5) members who are appointed by the...

  6. 18 CFR 375.101 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false The Commission. 375.101... OF ENERGY REVISED GENERAL RULES THE COMMISSION General Provisions § 375.101 The Commission. (a) Establishment. The Federal Energy Regulatory Commission is an independent regulatory commission within the...

  7. 18 CFR 375.101 - The Commission.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Section 375.101 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REVISED GENERAL RULES THE COMMISSION General Provisions § 375.101 The Commission. (a) Establishment. The Federal Energy Regulatory Commission is an independent regulatory commission within the...

  8. Fenpropathrin biodegradation pathway in Bacillus sp. DG-02 and its potential for bioremediation of pyrethroid-contaminated soils.

    PubMed

    Chen, Shaohua; Chang, Changqing; Deng, Yinyue; An, Shuwen; Dong, Yi Hu; Zhou, Jianuan; Hu, Meiying; Zhong, Guohua; Zhang, Lian-Hui

    2014-03-12

    The widely used insecticide fenpropathrin in agriculture has become a public concern because of its heavy environmental contamination and toxic effects on mammals, yet little is known about the kinetic and metabolic behaviors of this pesticide. This study reports the degradation kinetics and metabolic pathway of fenpropathrin in Bacillus sp. DG-02, previously isolated from the pyrethroid-manufacturing wastewater treatment system. Up to 93.3% of 50 mg L(-1) fenpropathrin was degraded by Bacillus sp. DG-02 within 72 h, and the degradation rate parameters qmax, Ks, and Ki were determined to be 0.05 h(-1), 9.0 mg L(-1), and 694.8 mg L(-1), respectively. Analysis of the degradation products by gas chromatography-mass spectrometry led to identification of seven metabolites of fenpropathrin, which suggest that fenpropathrin could be degraded first by cleavage of its carboxylester linkage and diaryl bond, followed by degradation of the aromatic ring and subsequent metabolism. In addition to degradation of fenpropathrin, this strain was also found to be capable of degrading a wide range of synthetic pyrethroids including deltamethrin, λ-cyhalothrin, β-cypermethrin, β-cyfluthrin, bifenthrin, and permethrin, which are also widely used insecticides with environmental contamination problems with the degradation process following the first-order kinetic model. Bioaugmentation of fenpropathrin-contaminated soils with strain DG-02 significantly enhanced the disappearance rate of fenpropathrin, and its half-life was sharply reduced in the soils. Taken together, these results depict the biodegradation mechanisms of fenpropathrin and also highlight the promising potentials of Bacillus sp. DG-02 in bioremediation of pyrethroid-contaminated soils.

  9. The [Ne III] Jet of DG Tau and its Ionization Scenarios

    NASA Astrophysics Data System (ADS)

    Liu, Chun-Fan; Shang, Hsien; Herczeg, Gregory J.; Walter, Frederick M.

    2016-12-01

    Forbidden neon emission from jets of low-mass young stars can be used to probe the underlying high-energy processes in these systems. We analyze spectra of the jet of DG Tau obtained with the Very Large Telescope/X-Shooter spectrograph in 2010. [Ne iii] λ 3869 is clearly detected in the innermost 3″ microjet and the outer knot located at ˜ 6\\buildrel{\\prime\\prime}\\over{.} 5. The velocity structure of the inner microjet can be decomposed into the low-velocity component at ˜ -70 km s-1 and the high-velocity component (HVC) at ˜ -180 km s-1. Based on the observed [Ne iii] flux and its spatial extent, we suggest the origins of the [Ne iii] emission regions and their relation with known X-ray sources along the jet. The flares from the hard X-ray source close to the star may be the main ionization source of the innermost microjet. The fainter soft X-ray source at 0\\buildrel{\\prime\\prime}\\over{.} 2 from the star may provide sufficient heating to help to sustain the ionization fraction against recombination in the flow. The outer knot may be reionized by shocks faster than 100 km s-1 such that [Ne iii] emission reappears and the soft X-ray emission at 5\\buildrel{\\prime\\prime}\\over{.} 5 is produced. Velocity decomposition of the archival Hubble Space Telescope spectra obtained in 1999 shows that the HVC had been faster, with a velocity centroid of ˜ -260 km s-1. Such a decrease in velocity may potentially be explained by the expansion of the stellar magnetosphere, changing the truncation radius and thus the launching speed of the jet. The energy released by magnetic reconnections during relaxation of the transition can heat the gas up to several tens of megakelvin and provide the explanation for on-source keV X-ray flares that ionize the neon microjet.

  10. 78 FR 32295 - Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ... presentations on the following items: (1) Presentation on upgrades to the Commission's Susquehanna Early Warning System program; (2) election of officers for FY-2014; (3) the proposed Water Resources Program; (4...

  11. TENTATIVE EVIDENCE FOR RELATIVISTIC ELECTRONS GENERATED BY THE JET OF THE YOUNG SUN-LIKE STAR DG Tau

    SciTech Connect

    Ainsworth, Rachael E.; Ray, Tom P.; Taylor, Andrew M.; Scaife, Anna M. M.; Green, David A.; Buckle, Jane V.

    2014-09-01

    Synchrotron emission has recently been detected in the jet of a massive protostar, providing further evidence that certain jet formation characteristics for young stars are similar to those found for highly relativistic jets from active galactic nuclei. We present data at 325 and 610 MHz taken with the Giant Metrewave Radio Telescope of the young, low-mass star DG Tau, an analog of the Sun soon after its birth. This is the first investigation of a low-mass young stellar object at such low frequencies. We detect emission with a synchrotron spectral index in the proximity of the DG Tau jet and interpret this emission as a prominent bow shock associated with this outflow. This result provides tentative evidence for the acceleration of particles to relativistic energies due to the shock impact of this otherwise very low-power jet against the ambient medium. We calculate the equipartition magnetic field strength B {sub min} ≈ 0.11 mG and particle energy E {sub min} ≈ 4 × 10{sup 40} erg, which are the minimum requirements to account for the synchrotron emission of the DG Tau bow shock. These results suggest the possibility of low energy cosmic rays being generated by young Sun-like stars.

  12. A Simultaneous Biogeography based Optimal Placement of DG Units and Capacitor Banks in Distribution Systems with Nonlinear Loads

    NASA Astrophysics Data System (ADS)

    Sadeghi, Hassan; Ghaffarzadeh, Navid

    2016-09-01

    This paper uses a new algorithm namely biogeography based optimization (BBO) intended for the simultaneous placement of the distributed generation (DG) units and the capacitor banks in the distribution network. The procedure of optimization has been conducted in the presence of nonlinear loads (a cause of harmonic injection). The purpose of simultaneous optimal placement of the DG and the capacitor is the reduction of active and reactive losses. The difference in the values of loss reduction at different levels of the load have been included in the objective function and the considered objective function includes the constraints of voltage, size and the number of DG units and capacitor banks and the allowable range of the total harmonic distortion (THD) of the total voltage in accordance with the IEEE 519 standards. In this paper the placement has been performed on two load types ie constant and mixed power, moreover the effects of load models on the results and the effects of optimal placement on reduction of the THD levels have also been analyzed. The mentioned cases have been studied on a 33 bus radial distribution system.

  13. Urinary C3dg and C5b-9 indicate active immune disease in human membranous nephropathy.

    PubMed

    Brenchley, P E; Coupes, B; Short, C D; O'Donoghue, D J; Ballardie, F W; Mallick, N P

    1992-04-01

    We have measured complement activation markers, C3dg and C5b-9 in plasma and urine from patients with idiopathic membranous nephropathy and IgA nephropathy. There was no significant difference in levels of plasma C5b-9 between the patient groups. However, high plasma concentrations of C3dg were associated significantly with IgA nephropathy with 45% of patients having levels over 25 U/ml (P less than 0.001). High concentrations of urinary C3dg and C5b-9 were associated significantly with membranous nephropathy (43% and 43% of the patient group, respectively) compared to patients with IgA nephropathy (10% and 0%, respectively, P less than 0.001). In a retrospective analysis of 31 patients with membranous nephropathy, 66% of patients with high initial urinary C5b-9 showed an unstable clinical course compared to 18% of patients with initially absent or low C5b-9 (P less than 0.001). We suggest that high urinary C5b-9 identifies those patients with a membranous lesion which retains an active immunological component contributing to the pathology of progressive glomerular damage.

  14. Influence of Underlap on Gate Stack DG-MOSFET for analytical study of Analog/RF performance

    NASA Astrophysics Data System (ADS)

    Kundu, Atanu; Dasgupta, Arpan; Das, Rahul; Chakraborty, Shramana; Dutta, Arka; Sarkar, Chandan K.

    2016-06-01

    In this paper, the characteristics of 18 nm Underlap Double Gate (U-DG) NMOSFET with gate stack, (GS) are presented. The high-k dielectric as gate insulator under consideration is Hafnium Dioxide (HfO2). The SiO2 padding reduces the effect of scattering at the silicon and oxide interface. The ratio of on current to off current is used for optimizing the underlap length. The Analog and RF performance comparison are shown in this paper considering the drain current (Id), the transconductance (gm), the intrinsic gain (gmRo), the intrinsic capacitances (Cgs, Cgd), the intrinsic resistances (Rgs, Rgd), the transport delay (τm), the intrinsic inductance (Hsd), the unity current gain cut-off frequency (fT) and the maximum frequency of oscillation (fmax). RF parameters are extracted using the Non Quasi Static (NQS) model of the U-DG MOSFET. The performance of single stage amplifiers using the devices is also analyzed. The sharpest transition is shown in case of U-DG-GS MOSFET with optimized underlap length and enhancement in the intrinsic capacitances and resistances, and unity Gain Bandwidth product in case of devices with GS.

  15. KINEMATICS OF THE OUTFLOW FROM THE YOUNG STAR DG TAU B: ROTATION IN THE VICINITIES OF AN OPTICAL JET

    SciTech Connect

    Zapata, Luis A.; Lizano, Susana; Rodríguez, Luis F.; Loinard, Laurent; Tafoya, Daniel; Ho, Paul T. P.; Fernández-López, Manuel

    2015-01-10

    We present {sup 12}CO(2-1) line and 1300 μm continuum observations made with the Submillimeter Array of the young star DG Tau B. We find, in the continuum observations, emission arising from the circumstellar disk surrounding DG Tau B. The {sup 12}CO(2-1) line observations, on the other hand, revealed emission associated with the disk and the asymmetric outflow related with this source. Velocity asymmetries about the flow axis are found over the entire length of the flow. The amplitude of the velocity differences is of the order of 1-2 km s{sup –1} over distances of about 300-400 AU. We interpret them as a result of outflow rotation. The sense of the outflow and disk rotation is the same. Infalling gas from a rotating molecular core cannot explain the observed velocity gradient within the flow. Magneto-centrifugal disk winds or photoevaporated disk winds can produce the observed rotational speeds if they are ejected from a Keplerian disk at radii of several tens of AU. Nevertheless, these slow winds ejected from large radii are not very massive, and cannot account for the observed linear momentum and angular momentum rates of the molecular flow. Thus, the observed flow is probably entrained material from the parent cloud. DG Tau B is a good laboratory to model in detail the entrainment process and see if it can account for the observed angular momentum.

  16. Differential responses of tumors and normal brain to the combined treatment of 2-DG and radiation in glioablastoma.

    PubMed

    Prasanna, Venkatesh K; Venkataramana, Neelam K; Dwarakanath, B S; Santhosh, Vani

    2009-09-01

    2-Deoxy-D-glucose (2-DG), an inhibitor of glucose transport and glycolysis, enhances radiation damage selectively in tumor cells by modulating damage response pathways resulting in cell death in vitro and local tumor control. Phase I and II clinical trials in patients with malignant glioma have shown excellent tolerance to a combined treatment of orally administered 2-DG and hypofractionated radiotherapy without any acute toxicity and late radiation damage. Phase III efficacy trials are currently at an advanced stage. Re-exploratory surgery performed in 13 patients due to persistent symptoms of elevated ICP and mass effect at different follow-up periods revealed extensive tumor necrosis with well-preserved normal brain tissue adjoining the tumor included in the treatment volume as revealed by a histological examination. These observations are perhaps the first clinical evidences for differential effects of 2-DG on tumors and normal tissues in conformity with earlier in vitro and in vivo studies in normal and tumor-bearing mice.

  17. DgSMC-B code: A robust and autonomous direct simulation Monte Carlo code for arbitrary geometries

    NASA Astrophysics Data System (ADS)

    Kargaran, H.; Minuchehr, A.; Zolfaghari, A.

    2016-07-01

    In this paper, we describe the structure of a new Direct Simulation Monte Carlo (DSMC) code that takes advantage of combinatorial geometry (CG) to simulate any rarefied gas flows Medias. The developed code, called DgSMC-B, has been written in FORTRAN90 language with capability of parallel processing using OpenMP framework. The DgSMC-B is capable of handling 3-dimensional (3D) geometries, which is created with first-and second-order surfaces. It performs independent particle tracking for the complex geometry without the intervention of mesh. In addition, it resolves the computational domain boundary and volume computing in border grids using hexahedral mesh. The developed code is robust and self-governing code, which does not use any separate code such as mesh generators. The results of six test cases have been presented to indicate its ability to deal with wide range of benchmark problems with sophisticated geometries such as airfoil NACA 0012. The DgSMC-B code demonstrates its performance and accuracy in a variety of problems. The results are found to be in good agreement with references and experimental data.

  18. Wisconsin SRF Electron Gun Commissioning

    SciTech Connect

    Bisognano, Joseph J.; Bissen, M.; Bosch, R.; Efremov, M.; Eisert, D.; Fisher, M.; Green, M.; Jacobs, K.; Keil, R.; Kleman, K.; Rogers, G.; Severson, M.; Yavuz, D. D.; Legg, Robert A.; Bachimanchi, Ramakrishna; Hovater, J. Curtis; Plawski, Tomasz; Powers, Thomas J.

    2013-12-01

    The University of Wisconsin has completed fabrication and commissioning of a low frequency (199.6 MHz) superconducting electron gun based on a quarter wave resonator (QWR) cavity. Its concept was optimized to be the source for a CW free electron laser facility. The gun design includes active tuning and a high temperature superconducting solenoid. We will report on the status of the Wisconsin SRF electron gun program, including commissioning experience and first beam measurements.

  19. NSF commission holds first meeting

    NASA Astrophysics Data System (ADS)

    Jones, Richard M.

    There has been considerable discussion in Washington science policy circles over the past few weeks about the newly established National Science Board Commission on the Future of the National Science Foundation. The commission, chaired by William Danforth, chancellor of Washington University, and Robert Galvin, former chief executive officer of Motorola, held its first meeting on September 17. Unfortunately, this meeting offered few indications of what changes might result from this exercise.

  20. Formation of a N2-dG:N2-dG Carbinolamine DNA Cross-link by the trans-4-Hydroxynonenal-Derived (6S,8R,11S) 1,N2-dG Adduct

    PubMed Central

    2011-01-01

    Michael addition of trans-4-hydroxynonenal (HNE) to deoxyguanosine yields diastereomeric 1,N2-dG adducts in DNA. When placed opposite dC in the 5′-CpG-3′ sequence, the (6S,8R,11S) diastereomer forms a N2-dG:N2-dG interstrand cross-link [Wang, H.; Kozekov, I. D.; Harris, T. M.; Rizzo, C. J. J. Am. Chem. Soc.2003, 125, 5687–5700]. We refined its structure in 5′-d(G1C2T3A4G5C6X7A8G9T10C11C12)-3′·5′-d(G13G14A15C16T17C18Y19C20T21A22G23C24)-3′ [X7 is the dG adjacent to the C6 carbon of the cross-link or the α-carbon of the (6S,8R,11S) 1,N2-dG adduct, and Y19 is the dG adjacent to the C8 carbon of the cross-link or the γ-carbon of the HNE-derived (6S,8R,11S) 1,N2-dG adduct; the cross-link is in the 5′-CpG-3′ sequence]. Introduction of 13C at the C8 carbon of the cross-link revealed one 13C8→H8 correlation, indicating that the cross-link existed predominantly as a carbinolamine linkage. The H8 proton exhibited NOEs to Y19 H1′, C20 H1′, and C20 H4′, orienting it toward the complementary strand, consistent with the (6S,8R,11S) configuration. An NOE was also observed between the HNE H11 proton and Y19 H1′, orienting the former toward the complementary strand. Imine and pyrimidopurinone linkages were excluded by observation of the Y19N2H and X7 N1H protons, respectively. A strong H8→H11 NOE and no 3J(13C→H) coupling for the 13C8–O–C11–H11 eliminated the tetrahydrofuran species derived from the (6S,8R,11S) 1,N2-dG adduct. The (6S,8R,11S) carbinolamine linkage and the HNE side chain were located in the minor groove. The X7N2 and Y19N2 atoms were in the gauche conformation with respect to the linkage, maintaining Watson–Crick hydrogen bonds at the cross-linked base pairs. A solvated molecular dynamics simulation indicated that the anti conformation of the hydroxyl group with respect to C6 of the tether minimized steric interaction and predicted hydrogen bonds involving O8H with C20O2 of the 5′-neighbor base pair G5·C20 and O11H with C

  1. Commission 16: Physical Study of Planets & Satellites

    NASA Astrophysics Data System (ADS)

    McGrath, Melissa A.; Lemmon, Mark T.; Courtin, Regis; Lara, Luisa M.; Kim, Sang Joon; Ksanfomality, Leonid V.; Morrison, David; Tejfel, Viktor G.; Yanamandra-Fisher, Padma A.

    2010-05-01

    The Business Meeting of IAU Commission 16 was held at the General Assembly in Rio de Janeiro on August 13, 2009. The meeting was called to order at 9:15am by Commission President, Régis Courtin, with 12 members present. Commission 16 now has 312 members, up from 271 at the last General Assembly. It is now the third largest Commission in Division III, after Commission 15 and Commission 51.

  2. Photonics21 and the perspectives from the European photonics industry

    NASA Astrophysics Data System (ADS)

    Mertin, Michael

    2014-03-01

    Photonics provide indispensable technology buildings bricks that enable a wide range of products as well as driving the development of entirely new industries. The European Commission recognized the potential of photonics to strengthen Europe's industrial and innovation capacity and consequently declared photonics as a Key Enabling Technology. Photonics21 as partner of the European Commission developed a Multiannual Strategic Roadmap which aims at boosting European photonics along the whole innovation chain with special focus on the gap between generating knowledge and products. The roadmap will be realized in a Public Private Partnership between the European photonics industry and the European Commission until 2020. In this PPP it is intended that the industry commits to leverage the public funds by the factor of 4.

  3. Mid-infrared interferometric variability of DG Tauri: Implications for the inner-disk structure

    NASA Astrophysics Data System (ADS)

    Varga, J.; Gabányi, K. É.; Ábrahám, P.; Chen, L.; Kóspál, Á.; Menu, J.; Ratzka, Th.; van Boekel, R.; Dullemond, C. P.; Henning, Th.; Jaffe, W.; Juhász, A.; Moór, A.; Mosoni, L.; Sipos, N.

    2017-08-01

    Context. DG Tau is a low-mass pre-main sequence star, whose strongly accreting protoplanetary disk exhibits a so-far enigmatic behavior: its mid-infrared thermal emission is strongly time-variable, even turning the 10 μm silicate feature from emission to absorption temporarily. Aims: We look for the reason for the spectral variability at high spatial resolution and at multiple epochs. Methods: Infrared interferometry can spatially resolve the thermal emission of the circumstellar disk, also giving information about dust processing. We study the temporal variability of the mid-infrared interferometric signal, observed with the VLTI/MIDI instrument at six epochs between 2011 and 2014. We fit a geometric disk model to the observed interferometric signal to obtain spatial information about the disk. We also model the mid-infrared spectra by template fitting to characterize the profile and time dependence of the silicate emission. We use physically motivated radiative transfer modeling to interpret the mid-infrared interferometric spectra. Results: The inner disk (r < 1-3 au) spectra exhibit a 10 μm absorption feature related to amorphous silicate grains. The outer disk (r > 1-3 au) spectra show a crystalline silicate feature in emission, similar to the spectra of comet Hale-Bopp. The striking difference between the inner and outer disk spectral feature is highly unusual among T Tauri stars. The mid-infrared variability is dominated by the outer disk. The strength of the silicate feature changed by more than a factor of two. Between 2011 and 2014 the half-light radius of the mid-infrared-emitting region decreased from 1.15 to 0.7 au. Conclusions: For the origin of the absorption we discuss four possible explanations: a cold obscuring envelope, an accretion heated inner disk, a temperature inversion on the disk surface and a misaligned inner geometry. The silicate emission in the outer disk can be explained by dusty material high above the disk plane, whose mass can

  4. Chronic Dietary Administration of the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG) Inhibits the Growth of Implanted Ehrlich’s Ascites Tumor in Mice

    PubMed Central

    Singh, Saurabh; Pandey, Sanjay; Bhatt, Anant Narayan; Chaudhary, Richa; Bhuria, Vikas; Kalra, Namita; Soni, Ravi; Roy, Bal Gangadhar; Saluja, Daman; Dwarakanath, Bilikere S.

    2015-01-01

    Background Dietary energy restriction (DER) has been well established as a potent anticancer strategy. Non-adoption of restricted diet for an extended period has limited its practical implementation in humans with a compelling need to develop agents that mimic effects similar to DER, without reduction in actual dietary intake. Glycolytic inhibitor, 2-deoxy-D-glucose (2-DG), has recently been shown to possess potential as an energy restriction mimetic agent (ERMA). In the present study we evaluated the effect of dietary 2-DG administration on a mouse tumor model, with a focus on several potential mechanisms that may account for the inhibition of tumorigenesis. Methodology/Principal Findings Swiss albino strain ‘A’ mice were administered with 0.2% and 0.4% w/v 2-DG in drinking water for 3 months prior to tumor implantation (Ehrlich’s ascites carcinoma; EAC) and continued till the termination of the study with no adverse effects on general physiology and animal growth. Dietary 2-DG significantly reduced the tumor incidence, delayed the onset, and compromised the tumor growth along with enhanced survival. We observed reduced blood glucose and serum insulin levels along with decreased proliferating cell nuclear antigen (PCNA) and bromodeoxyuridine positive (BrdU+) tumor cells in 2-DG fed mice. Also, reduced levels of certain key players of metabolic pathways such as phosphatidylinositol 3-kinase (PI3K), phosphorylated-Akt and hypoxia inducible factor-1 alpha (HIF-1α) were also noted in tumors of 2-DG fed mice. Further, decrease in CD4+/CD8+ ratio and T-regulatory cells observed in 2-DG fed mice suggested enhanced antitumor immunity and T cell effector function. Conclusion/Significance These results strongly suggest that dietary 2-DG administration in mice, at doses easily achievable in humans, suitably modulates several pleotrophic factors mimicking DER and inhibits tumorigenesis, emphasizing the use of ERMAs as a promising cancer preventive strategy. PMID

  5. Experimental evaluation of the glucose antimetabolite, 2-deoxy-D-glucose (2-DG) as a possible adjuvant to radiotherapy of tumors: I. Kinetics of growth and survival of ehrlich ascites tumor cells (EATC) in vitro and of growth of solid tumors after 2-DG and x-irradiation

    SciTech Connect

    Purohit, S.C.; Pohlit, W.

    1982-03-01

    Modifications of cell proliferation and survival induced by 2-DG and X-irradiation alone or in combination were studied under both aerobic and hypoxic conditions and for cells both in exponential and plateau phase. The degree of inhibition of cell proliferation was found to be dependent on absorbed dose of X rays and on the 2-DG/Glucose Molar ratio in the medium. At an equimolar ratio (2-DG/Glucose = 1) in nutrient medium the growth of euoxic EATC was ihibited by 80% relative to the control (without 2-DG). This inhibition was fully reversible up to 48 hours of the culture inoculation if 2-DG was removed from the medium, demonstrating the importance of glucose and glycolysis for tumor growth. The inhibitory effects of 2-DG on the viability of cultured cells when applied alone or in combination with radiation was found to be more pronounced in hypoxic cells than in euoxic cells. The combined effect of both noxae (2-DG and X-irradiation) on the growth inhibition of euoxic EATC in cultures was slightly more than additive, while they were clearly snyergistic on the growth inhibition of solid tumors in vivo. As tumors are known to have a fraction of hypoxic cells, it seems likely that synergistic action of 2-DG results from the stronger effect of 2-DG on these cells. The reason for the stronger effect may be a result of inhibition of their glycolytic energy supply limiting repair processes. Our results suggest that 2-DG could be used to advantage as an adjuvant in radiotherapy of human tumors.

  6. European Flood Awareness System - now operational

    NASA Astrophysics Data System (ADS)

    Alionte Eklund, Cristina.; Hazlinger, Michal; Sprokkereef, Eric; Garcia Padilla, Mercedes; Garcia, Rafael J.; Thielen, Jutta; Salamon, Peter; Pappenberger, Florian

    2013-04-01

    The European Commission's Communication "Towards a Stronger European Union Disaster Response" adopted and endorsed by the Council in 2010, underpins the importance of strengthening concerted actions for natural disasters including floods, which are amongst the costliest natural disasters in the EU. The European Flood Awareness System (EFAS) contributes in the case of major flood events. to better protection of the European Citizen, the environment, property and cultural heritage. The disastrous floods in Elbe and Danube rivers in 2002 confronted the European Commission with non-coherent flood warning information from different sources and of variable quality, complicating planning and organisation of aid. Thus, the Commission initiated the development of a European Flood Awareness System (EFAS) which is now going operational. EFAS has been developed and tested at the Joint Research Centre, the Commission's in house science service, in close collaboration with the National hydrological and meteorological services, European Civil Protection through the Monitoring and Information Centre (MIC) and other research institutes. EFAS provides Pan-European overview maps of flood probabilities up to 10 days in advance as well as detailed forecasts at stations where the National services are providing real time data. More than 30 hydrological services and civil protection services in Europe are part of the EFAS network. Since 2011, EFAS is part of the COPERNICUS Emergency Management Service, (EMS) and is now an operational service since 2012. The Operational EFAS is being executed by several consortia dealing with different operational aspects: • EFAS Hydrological data collection centre —REDIAM and ELIMCO- will be collecting historic and realtime discharge and water levels data in support to EFAS • EFAS Meteorological data collection centre —outsourced but running onsite of JRC Ispra. Will be collecting historic and realtime meteorological data in support to EFAS

  7. Commission 41: History of Astronomy

    NASA Astrophysics Data System (ADS)

    Gurshtein, Alexander A.; Nha, Il-Seong; Ruggles, Clive L. N.; DeVorkin, David H.; Dick, Wolfgang R.; Kochhar, Rajesh; Nakamura, Tsuko; Pigatto, Luisa; Stephenson, F. Richard; Warner, Brian

    2007-12-01

    On Tuesday 22 August 2006 approximately 40 people attended the Commission 41 History of Astronomy Business Meeting at the IAU XXVI General Assembly in Prague. Commission president Alex Gurshtein opened the meeting, welcoming the commission members and calling for a moment of silence for those members who passed away in the last triennium. David DeVorkin was appointed recording secretary for the meeting, with Steven Dick as the scruitineer of the ballot. A moment of silence was then observed in the memory of members departed over the last triennium, including: Jerzy Dobrzycki (Poland), Robert Duncan (Australia), Mohammad Edalati (Iran), Philip Morrison (USA), John Perdix (Australia), Neil Porter (Ireland), Gibson Reaves (USA), Brian Robinson (Australia), and Raymond E. White (USA).

  8. Commission 41: History of Astronomy

    NASA Astrophysics Data System (ADS)

    Ruggles, Clive; Kochhar, Rajesh; Il-Seong, Nha; Belmonte, Juan; Corbin, Brenda; de Jong, Teije; Norris, Ray; Pigatto, Luisa; Soma, Mitsuru; Sterken, Chris; Xiaochun, Sun

    2012-04-01

    Commission 41 was created at the VIIth IAU General Assembly in Zürich in 1948. From an inauspicious start-Otto Neugebauer was appointed the first President in his absence, but proceeded to express his conviction that ``an international organization in the history of astronomy has no positive function. . .my only activity during my term of service consisted in iterated attempts to resign''-the Commission quickly assumed a key role in the international development of the history of astronomy as an academic discipline.

  9. 10 CFR 1.11 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false The Commission. 1.11 Section 1.11 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters § 1.11 The Commission. (a) The Nuclear Regulatory Commission, composed of five members, one of whom is designated by the...

  10. 17 CFR 140.10 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false The Commission. 140.10 Section..., AND PROCEDURES OF THE COMMISSION Functions § 140.10 The Commission. The Commission is composed of a Chairman and four other Commissioners, not more than three of whom may be members of the same political...

  11. 17 CFR 140.10 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 2 2014-04-01 2014-04-01 false The Commission. 140.10 Section...) ORGANIZATION, FUNCTIONS, AND PROCEDURES OF THE COMMISSION Functions § 140.10 The Commission. The Commission is composed of a Chairman and four other Commissioners, not more than three of whom may be members of the same...

  12. 17 CFR 140.10 - The Commission.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false The Commission. 140.10 Section..., AND PROCEDURES OF THE COMMISSION Functions § 140.10 The Commission. The Commission is composed of a Chairman and four other Commissioners, not more than three of whom may be members of the same political...

  13. 17 CFR 140.10 - The Commission.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false The Commission. 140.10 Section..., AND PROCEDURES OF THE COMMISSION Functions § 140.10 The Commission. The Commission is composed of a Chairman and four other Commissioners, not more than three of whom may be members of the same political...

  14. 16 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false The Commission. 0.1 Section 0.1 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ORGANIZATION § 0.1 The Commission. The Federal Trade Commission is an independent administrative agency which was organized in 1915...

  15. 10 CFR 1.11 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false The Commission. 1.11 Section 1.11 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters § 1.11 The Commission. (a) The Nuclear Regulatory Commission, composed of five members, one of whom is designated by the...

  16. 16 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false The Commission. 0.1 Section 0.1 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ORGANIZATION § 0.1 The Commission. The Federal Trade Commission is an independent administrative agency which was organized in 1915...

  17. 10 CFR 1.11 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false The Commission. 1.11 Section 1.11 Energy NUCLEAR REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters § 1.11 The Commission. (a) The Nuclear Regulatory Commission, composed of five members, one of whom is designated by the...

  18. 17 CFR 140.10 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false The Commission. 140.10 Section..., AND PROCEDURES OF THE COMMISSION Functions § 140.10 The Commission. The Commission is composed of a Chairman and four other Commissioners, not more than three of whom may be members of the same political...

  19. 16 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false The Commission. 0.1 Section 0.1 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ORGANIZATION § 0.1 The Commission. The Federal Trade Commission is an independent administrative agency which was organized in 1915...

  20. 16 CFR 4.15 - Commission meetings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Commission meetings. 4.15 Section 4.15... RULES § 4.15 Commission meetings. (a) In general. (1) Meetings of the Commission, as defined in 5 U.S.C... announcements of meetings. For each meeting, the Commission shall announce: (i) The time, place and subject...

  1. Federal Communications Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... Part XVIII Federal Communications Commission Semiannual Regulatory Agenda ] FEDERAL COMMUNICATIONS COMMISSION (FCC) FEDERAL COMMUNICATIONS COMMISSION 47 CFR Ch. I Unified Agenda of Federal Regulatory and Deregulatory Actions AGENCY: Federal Communications Commission. ACTION: Semiannual regulatory agenda. SUMMARY: Twice a year, in spring and fall...

  2. 10 CFR 110.91 - Commission consultations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Commission consultations. 110.91 Section 110.91 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Public Participation Procedures Concerning License Applications § 110.91 Commission consultations. The Commission...

  3. Quantifying Metabolic Heterogeneity in Head and Neck Tumors in Real Time: 2-DG Uptake Is Highest in Hypoxic Tumor Regions

    PubMed Central

    Nakajima, Erica C.; Laymon, Charles; Oborski, Matthew; Hou, Weizhou; Wang, Lin; Grandis, Jennifer R.; Ferris, Robert L.; Mountz, James M.; Van Houten, Bennett

    2014-01-01

    Purpose Intratumoral metabolic heterogeneity may increase the likelihood of treatment failure due to the presence of a subset of resistant tumor cells. Using a head and neck squamous cell carcinoma (HNSCC) xenograft model and a real-time fluorescence imaging approach, we tested the hypothesis that tumors are metabolically heterogeneous, and that tumor hypoxia alters patterns of glucose uptake within the tumor. Experimental Design Cal33 cells were grown as xenograft tumors (n = 16) in nude mice after identification of this cell line's metabolic response to hypoxia. Tumor uptake of fluorescent markers identifying hypoxia, glucose import, or vascularity was imaged simultaneously using fluorescent molecular tomography. The variability of intratumoral 2-deoxyglucose (IR800-2-DG) concentration was used to assess tumor metabolic heterogeneity, which was further investigated using immunohistochemistry for expression of key metabolic enzymes. HNSCC tumors in patients were assessed for intratumoral variability of 18F-fluorodeoxyglucose (18F-FDG) uptake in clinical PET scans. Results IR800-2-DG uptake in hypoxic regions of Cal33 tumors was 2.04 times higher compared to the whole tumor (p = 0.0001). IR800-2-DG uptake in tumors containing hypoxic regions was more heterogeneous as compared to tumors lacking a hypoxic signal. Immunohistochemistry staining for HIF-1α, carbonic anhydrase 9, and ATP synthase subunit 5β confirmed xenograft metabolic heterogeneity. We detected heterogeneous 18F-FDG uptake within patient HNSCC tumors, and the degree of heterogeneity varied amongst tumors. Conclusion Hypoxia is associated with increased intratumoral metabolic heterogeneity. 18F-FDG PET scans may be used to stratify patients according to the metabolic heterogeneity within their tumors, which could be an indicator of prognosis. PMID:25127378

  4. Roles of DgBRC1 in Regulation of Lateral Branching in Chrysanthemum (Dendranthema ×grandiflora cv. Jinba)

    PubMed Central

    Chen, Xiaoli; Zhou, Xiaoyang; Xi, Lin; Li, Junxiang; Zhao, Ruiyan; Ma, Nan; Zhao, Liangjun

    2013-01-01

    The diverse plasticity of plant architecture is largely determined by shoot branching. Shoot branching is an event regulated by multiple environmental, developmental and hormonal stimuli through triggering lateral bud response. After perceiving these signals, the lateral buds will respond and make a decision on whether to grow out. TCP transcriptional factors, BRC1/TB1/FC1, were previously proven to be involved in local inhibition of shoot branching in Arabidopsis, pea, tomato, maize and rice. To investigate the function of BRC1, we isolated the BRC1 homolog from chrysanthemum. There were two transcripts of DgBRC1 coming from two alleles in one locus, both of which complemented the multiple branches phenotype of Arabidopsis brc1-1, indicating that both are functionally conserved. DgBRC1 was mainly expressed in dormant axillary buds, and down-regulated at the bud activation stage, and up-regulated by higher planting densities. DgBRC1 transcripts could respond to apical auxin supply and polar auxin transport. Moreover, we found that the acropetal cytokinin stream promoted branch outgrowth whether or not apical auxin was present. Basipetal cytokinin promoted outgrowth of branches in the absence of apical auxin, while strengthening the inhibitory effects on lower buds in the presence of apical auxin. The influence of auxin and strigolactons (SLs) on the production of cytokinin was investigated, we found that auxin locally down-regulated biosynthesis of cytokinin in nodes, SLs also down-regulated the biosynthesis of cytokinin, the interactions among these phytohormones need further investigation. PMID:23613914

  5. Willingness for Mobility amongst European Fishermen

    ERIC Educational Resources Information Center

    Pita, Cristina; Dickey, Heather; Pierce, Graham J.; Mente, Elena; Theodossiou, Ioannis

    2010-01-01

    The global trend of fisheries overexploitation and collapse has resulted in the need to reduce fishing effort, and providing alternative employment for fishermen is a frequently mentioned policy option in order to achieve this goal. Reducing fishing effort is central to the European Commission Common Fisheries Policy and over the years, the…

  6. Willingness for Mobility amongst European Fishermen

    ERIC Educational Resources Information Center

    Pita, Cristina; Dickey, Heather; Pierce, Graham J.; Mente, Elena; Theodossiou, Ioannis

    2010-01-01

    The global trend of fisheries overexploitation and collapse has resulted in the need to reduce fishing effort, and providing alternative employment for fishermen is a frequently mentioned policy option in order to achieve this goal. Reducing fishing effort is central to the European Commission Common Fisheries Policy and over the years, the…

  7. The Rise of the Information Society amongst European Academics

    ERIC Educational Resources Information Center

    Salajan, Florin D.

    2008-01-01

    This study investigates the information society discourse in the European Union in relation to the European Commission's eLearning programmes, based on selected academics' conceptualisation of the term. It reveals a mixed picture of the perceptions that academics have of the information society in their respective countries. The findings indicate…

  8. TELRI: Trans European Language Resources Infrastructure Newsletter, 1995-1997.

    ERIC Educational Resources Information Center

    TELRI: Trans European Language Resources Infrastructure Newsletter, 1997

    1997-01-01

    The first seven issues of the Trans European Language Resources Infrastructure (TELRI) newsletter, a publication of the COPERNICUS project funded by the Commission of the European Communities, date from September 1995 to October 1997. The first three issues contain articles in the origins of TELRI, its members, working groups, and events. TELRI's…

  9. The Rise of the Information Society amongst European Academics

    ERIC Educational Resources Information Center

    Salajan, Florin D.

    2008-01-01

    This study investigates the information society discourse in the European Union in relation to the European Commission's eLearning programmes, based on selected academics' conceptualisation of the term. It reveals a mixed picture of the perceptions that academics have of the information society in their respective countries. The findings indicate…

  10. Houston READ Commission Success Stories.

    ERIC Educational Resources Information Center

    Houston READ Commission, TX.

    This document highlights some of the success stories resulting from the activities of the Houston READ Commission (HRC), a nonprofit urban literacy coalition created by the Mayor and City Council of the Greater Houston area. It relates the stories of "those who are the future," lists gifts which support HRC programs, and donors and…

  11. Commission 12: Solar Radiation & Structure

    NASA Astrophysics Data System (ADS)

    Bogdan, Thomas. J.; Martínez Pillet, Valentin; Asplund, M.; Christensen-Dalsgaard, J.; Cauzzi, G.; Cram, L. E.; Dravins, D.; Gan, W.; Henzl, P.; Kosovichev, A.; Mariska, J. T.; Rovira, M. G.; Venkatakrishnan, P.

    2007-03-01

    Commission 12 covers research on the internal structure and dynamics of the Sun, the "quiet" solar atmosphere, solar radiation and its variability, and the nature of relatively stable magnetic structures like sunspots, faculae and the magnetic network. There is considerable productive overlap with the other Commissions of Division II as investigations move progressively toward the fertile intellectual boundaries between traditional research disciplines. In large part, the solar magnetic field provides the linkage that connects these diverse themes. The same magnetic field that produces the more subtle variations of solar structure and radiative output over the 11 yr activity cycle is also implicated in rapid and often violent phenomena such as flares, coronal mass ejections, prominence eruptions, and episodes of sporadic magnetic reconnection.The last three years have again brought significant progress in nearly all the research endeavors touched upon by the interests of Commission 12. The underlying causes for this success remain the same: sustained advances in computing capabilities coupled with diverse observations with increasing levels of spatial, temporal and spectral resolution. It is all but impossible to deal with these many advances here in anything except a cursory and selective fashion. Thankfully, the Living Reviews in Solar Physics; has published several extensive reviews over the last two years that deal explicitly with issues relevant to the purview of Commission 12. The reader who is eager for a deeper and more complete understanding of some of these advances is directed to http://www.livingreviews.org for access to these articles.

  12. DG-CST (Disease Gene Conserved Sequence Tags), a database of human–mouse conserved elements associated to disease genes

    PubMed Central

    Boccia, Angelo; Petrillo, Mauro; di Bernardo, Diego; Guffanti, Alessandro; Mignone, Flavio; Confalonieri, Stefano; Luzi, Lucilla; Pesole, Graziano; Paolella, Giovanni; Ballabio, Andrea; Banfi, Sandro

    2005-01-01

    The identification and study of evolutionarily conserved genomic sequences that surround disease-related genes is a valuable tool to gain insight into the functional role of these genes and to better elucidate the pathogenetic mechanisms of disease. We created the DG-CST (Disease Gene Conserved Sequence Tags) database for the identification and detailed annotation of human–mouse conserved genomic sequences that are localized within or in the vicinity of human disease-related genes. CSTs are defined as sequences that show at least 70% identity between human and mouse over a length of at least 100 bp. The database contains CST data relative to over 1088 genes responsible for monogenetic human genetic diseases or involved in the susceptibility to multifactorial/polygenic diseases. DG-CST is accessible via the internet at http://dgcst.ceinge.unina.it/ and may be searched using both simple and complex queries. A graphic browser allows direct visualization of the CSTs and related annotations within the context of the relative gene and its transcripts. PMID:15608249

  13. VARIATIONS OF THE 10 mum SILICATE FEATURES IN THE ACTIVELY ACCRETING T TAURI STARS: DG Tau AND XZ Tau

    SciTech Connect

    Bary, Jeffrey S.; Leisenring, Jarron M.; Skrutskie, Michael F. E-mail: jml2u@virginia.ed

    2009-11-20

    Using the Infrared Spectrograph aboard the Spitzer Space Telescope, we observed multiple epochs of 11 actively accreting T Tauri stars in the nearby Taurus-Auriga star-forming region. In total, 88 low-resolution mid-infrared spectra were collected over 1.5 years in Cycles 2 and 3. The results of this multi-epoch survey show that the 10 mum silicate complex in the spectra of two sources-DG Tau and XZ Tau-undergoes significant variations with the silicate feature growing both weaker and stronger over month- and year-long timescales. Shorter timescale variations on day- to week-long timescales were not detected within the measured flux errors. The time resolution coverage of this data set is inadequate for determining if the variations are periodic. Pure emission compositional models of the silicate complex in each epoch of the DG Tau and XZ Tau spectra provide poor fits to the observed silicate features. These results agree with those of previous groups that attempted to fit only single-epoch observations of these sources. Simple two-temperature, two-slab models with similar compositions successfully reproduce the observed variations in the silicate features. These models hint at a self-absorption origin of the diminution of the silicate complex instead of a compositional change in the population of emitting dust grains. We discuss several scenarios for producing such variability including disk shadowing, vertical mixing, variations in disk heating, and disk wind events associated with accretion outbursts.

  14. EMODNet Bathymetry - building and providing a high resolution digital bathymetry for European seas

    NASA Astrophysics Data System (ADS)

    Schaap, Dick M. A.

    2015-04-01

    Access to marine data is a key issue for the implementation of the EU Marine Strategy Framework Directive (MSFD). The EU communication 'Marine Knowledge 2020' underpins the importance of data availability and harmonising access to marine data from different sources. The European Marine Observation and Data Network (EMODnet) is a long term marine data initiative from the European Commission Directorate-General for Maritime Affairs and Fisheries (DG MARE) underpinning the Marine Knowledge 2020 strategy. EMODnet is a consortium of organisations assembling European marine data, data products and metadata from diverse sources in a uniform way. The main purpose of EMODnet is to unlock fragmented and hidden marine data resources and to make these available to individuals and organisations (public and private), and to facilitate investment in sustainable coastal and offshore activities through improved access to quality-assured, standardised and harmonised marine data which are interoperable and free of restrictions on use. The EMODnet data infrastructure is developed through a stepwise approach in three major phases. Currently EMODnet is in the 2nd phase of development with seven sub-portals in operation that provide access to marine data from the following themes: bathymetry, geology, physics, chemistry, biology, seabed habitats and human activities. EMODnet development is a dynamic process so new data, products and functionality are added regularly while portals are continuesly improved to make the service more fit for purpose and user friendly with the help of users and stakeholders. The EMODnet Bathymetry project develops and publishes Digital Terrain Models (DTM) for the European seas. These are produced from survey and aggregated data sets, that are indexed with metadata by adopting the SeaDataNet Common Data Index (CDI) data discovery and access service and the SeaDataNet Sextant data products catalogue service. The new EMODnet DTM will have a resolution of 1

  15. Commissioning of the LCLS LINAC

    SciTech Connect

    Loos, H.; Akre, R.; Brachmann, A.; Decker, F.-J.; Ding, Y.; Dowell, D.; Emma, P.; Frisch, J.; Gilevich, S.; Hays, G.; Hering, Ph.; Huang, Z.; Iverson, R.; Limborg-Deprey, C.; Miahnahri, A.; Molloy, S.; Nuhn, H.-D.; Turner, J.; Welch, J.; White, W.; Wu, J.; /SLAC /Stanford U., Appl. Phys. Dept.

    2010-06-11

    The Linac Coherent Light Source (LCLS) X-ray free electron laser project is currently under construction at the Stanford Linear Accelerator Center (SLAC). A new injector and upgrades to the existing accelerator were installed in two phases in 2006 and 2007. We report on the commissioning of the injector, the two new bunch compressors at 250MeV and 4.3 GeV, and transverse and longitudinal beam diagnostics up to the end of the existing linac at 13.6 GeV. The commissioning of the new transfer line from the end of the linac to the undulator is scheduled to start in November 2008 and for the undulator in March 2009 with first light to be expected in July 2009.

  16. Surrogacy commissioning fathers and HIV.

    PubMed

    Jordaan, Donrich W

    2013-10-11

    Surrogacy is not regulated by a single legal instrument only, nor is confirmation of a surrogacy agreement by the High Court an unqualified green light for the surrogacy process to proceed. In the context of the HIV status of the commissioning father, whose gametes are to be used for the conception of the child in pursuance of a surrogacy agreement, the intended in vitro fertilisation of the surrogate mother may only take place on condition that the commissioning father, and his semen, have been tested for HIV; that he has consented to his HIV status being made available to the surrogate mother, and if he is HIV-positive, that sperm washing will be used to minimise the risk of infection and that the surrogate mother has been informed of his HIV status, and given her informed consent. 

  17. Protective role of CYP2E1 inhibitor diallyl disulfide (DADS) on alcohol-induced malondialdehyde-deoxyguanosine (M1dG) adduct formation.

    PubMed

    Sapkota, Muna; Hottor, Tete K; DeVasure, Jane M; Wyatt, Todd A; McCaskill, Michael L

    2014-06-01

    Alcohol use disorders are often associated with lung disease. Alcohol exposure leads to the production of reactive oxygen species, lipid peroxidation, and formation of malondialdehyde (MDA) as well as to induce the expression of cytochrome p450 2E1 (CYP2E1). Likewise, cigarette smoking can lead to lung lipid peroxidation and formation of MDA. MDA can bind to DNA forming MDA-deoxyguanosine (M1dG) adducts, which have been implicated in alcohol-related cancers and cardiovascular disease. Because CYP2E1 regulates MDA production, and our previous studies have shown that alcohol and cigarette smoke can lead to MDA formation, we hypothesized that CYP2E1 would modulate M1dG adduct formation and single-strand DNA damage in alcohol- and cigarette smoke-exposed lung cells and tissue. Normal human bronchial epithelial cells (HBECs) were pretreated with 10 μM diallyl disulfide (DADS) for 1 hour and treated with 80 mM ethanol (EtOH) ± 5% cigarette smoke extract (CSE) for 3 hours for comet assay and 6 hours for CYP2E1, MDA, and M1dG adduct assays. C57BL/6 mice were administered 20% EtOH ad libitum in drinking water for 8 weeks and exposed to whole-body cigarette smoke for 5 weeks. Mice were also fed a CYP2E1 inhibitor, DADS, at 1 μM/g of feed in their daily diet for 7 weeks. Whole lung tissue homogenate was used for CYP2E1, MDA, and M1dG adduct assays. EtOH exposure significantly increased HBEC olive tail moment. DADS pretreatment of HBECs attenuated this EtOH effect. EtOH also induced MDA and M1dG adduct formation, which was also significantly reduced by DADS treatment. CSE ± EtOH did not enhance these effects. In lung tissue homogenate of 8-week alcohol-fed mice, MDA and M1dG adduct levels were significantly elevated in comparison with control mice and mice fed DADS while consuming alcohol. No increase in MDA and M1dG adduct formation was observed in 5-week cigarette smoke-exposed mice. These findings suggest that CYP2E1 plays a pivotal role in alcohol-induced M1dG adducts

  18. Protective Role of CYP2E1 Inhibitor Diallyl Disulfide (DADS) on Alcohol Induced Malondialdehyde-Deoxyguanosine (M1dG) Adduct Formation

    PubMed Central

    Sapkota, M.; Hottor, T. K.; DeVasure, J. M.; Wyatt, T. A.; McCaskill, M. L.

    2014-01-01

    Background Alcohol use disorders are often associated with lung disease. Alcohol exposure leads to the production of reactive oxygen species, lipid peroxidation, and formation of malondialdehyde (MDA) as well as induce the expression of cytochrome p450 2E1 (CYP2E1). Likewise, cigarette smoking can lead to lung lipid peroxidation and formation of MDA. MDA can bind to DNA forming MDA deoxyguanosine (M1dG) adducts, which have been implicated in alcohol-related cancers and cardiovascular disease. Because CYP2E1 regulates MDA production, and our previous studies have shown that alcohol and cigarette smoke can lead to MDA formation, we hypothesized that CYP2E1 would modulate M1dG adduct formation and single strand DNA damage in alcohol- and cigarette smoke-exposed lung cells and tissue. Methods Normal human bronchial epithelial cells (HBEC) were pre-treated with 10 μM DADS for 1h, and treated with 80 mM ethanol +/− 5% cigarette smoke extract (CSE) for 3 hrs for comet assay and 6 hrs for CYP2E1, MDA, and M1dG adduct assays. C57BL/6 mice were administered 20% ethanol ad libitum in drinking water for 8 wk and exposed to whole body cigarette smoke for 5 wk. Mice were also fed a CYP2E1 inhibitor, diallyl disulfide (DADS), at 1 μM/g of feed in their daily diet for 7 wk. Whole lung tissue homogenate was used for CYP2E1, MDA, and M1dG adduct assays. Results Ethanol exposure significantly increased HBEC olive tail moment. DADS pretreatment of HBEC attenuated this ethanol effect. Ethanol also induced MDA and M1dG adduct formation, which was also significantly reduced by DADS treatment. CSE +/− ethanol did not enhance these effects. In lung tissue homogenate of 8 wk alcohol-fed mice, MDA and M1dG adduct levels were significantly elevated in comparison to control mice and mice fed DADS while consuming alcohol. No increase in MDA and M1dG adduct formation was observed in 5 wk cigarette smoke-exposed mice. Conclusions These findings suggest that CYP2E1 plays a pivotal role in

  19. Population commission discusses international migration.

    PubMed

    1997-01-01

    At the 30th session of the Commission on Population and Development during February 24-28, 1997, international migration was the main topic, with special linkages between migration and development and on gender issues and the family. New and emerging issues were also considered. Members stressed the need for more reliable data on migration, the direction of migrants flows, and the characteristics of migrants. The Commission requested a task force on basic social services to hold a technical symposium of experts on international migration in 1998. Its chair, Dr. Nafis Sadik, said that migration issues should based on the reality of choice not on coercive measures or quotas. Almost half of the migrants globally are women. The Commission was given a new impetus by the International Conference on Population and Development held at Cairo in 1994. Migration pressures intensified in the second half of the 1980s and in the early 1990s, creating areas of concern: the negative impact of short-term migration on working conditions in host countries; migration pressures emanating from climatic change; the protection of migrant women and their children; the right of receiving countries to regulate access to their territory; the adverse consequences of forced migration; the situation of persons whose asylum claims have been rejected; the trafficking in women and children, prostitution and coercive adoption; and the sudden and massive arrival of refugees in need of international protection. The 1998 session of the Commission will feature the theme of health and mortality, with special emphasis on the linkages between health and development and on gender and age.

  20. Sentinel-3A: first commissioning results of its optical payload

    NASA Astrophysics Data System (ADS)

    Nieke, J.; Mavrocordatos, C.; Berruti, B.

    2016-10-01

    The Sentinel-3A satellite, the first of a series of four satellites from the European Commission's Copernicus Programme, was launched on the 16th of February 2016. Sentinel-3 is a multi-instrument mission to measure sea-surface topography, sea- and land-surface temperature, ocean colour and land colour to support ocean forecasting systems, as well as environmental and climate monitoring. The presentation will focus on Sentinel-3 optical instruments, namely the Ocean Land Colour Imager (OLCI) and the Sea and Land Surface Temperature Radiometer (SLSTR). The results of the five-month commissioning phase (concluded in July 2016) are presented. The Level-1 product quality is presented as well as preliminary verification and validation results of the Level-2 ocean products.

  1. 78 FR 57818 - Commission Participation and Commission Employee Involvement in Voluntary Standards Activities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-20

    ... From the Federal Register Online via the Government Publishing Office CONSUMER PRODUCT SAFETY... Standards Activities AGENCY: Consumer Product Safety Commission. ACTION: Notice of proposed rulemaking. SUMMARY: The United States Consumer Product Safety Commission (Commission or CPSC) is issuing a...

  2. 2-Amino-2-deoxy-glucose conjugated cobalt ferrite magnetic nanoparticle (2DG-MNP) as a targeting agent for breast cancer cells.

    PubMed

    Aşık, Elif; Aslan, Tuğba Nur; Volkan, Mürvet; Güray, N Tülin

    2016-01-01

    In this study, 2-amino-2-deoxy-glucose (2DG) was conjugated to COOH modified cobalt ferrite magnetic nanoparticles (COOH-MNPs), which were designed to target tumor cells as a potential targetable drug/gene delivery agent for cancer treatment. According to our results, it is apparent that, 2DG labeled MNPs were internalized more efficiently than COOH-MNPs under the same conditions in all cell types (MDA-MB-231 and MCF-7 cancer and MCF-10A normal breast cells) (p<0.001). Moreover, the highest amount of uptake was observed in MDA-MB-231, followed by MCF-7 and normal MCF-10A cells for both MNPs. The apoptotic effects of 2DG-MNPs were further evaluated, and it was found that apoptosis was not induced at low concentrations of 2DG-MNPs in all cell types, whereas dramatic cell death was observed at higher concentrations. In addition, the gene expression levels of four drug-metabolizing enzymes, two Phase I (CYP1A1, CYP1B1) and two Phase II (GSTM3, GSTZ1) were also increased with the high concentrations of 2DG-MNPs. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. The Politics of the Economics of Education in the European Union

    ERIC Educational Resources Information Center

    Jones, Peter

    2010-01-01

    This article critically examines the work of the European Commission-sponsored network, the European Expert Network on Economics of Education (EENEE). The aim is to develop understanding of the context and significance of the mobilization of the economics of education research and policy paradigm within the European Union's Education and Training…

  4. The Politics of the Economics of Education in the European Union

    ERIC Educational Resources Information Center

    Jones, Peter

    2010-01-01

    This article critically examines the work of the European Commission-sponsored network, the European Expert Network on Economics of Education (EENEE). The aim is to develop understanding of the context and significance of the mobilization of the economics of education research and policy paradigm within the European Union's Education and Training…

  5. Employment and Status of Teachers in State Schools in the European Community. Analysis.

    ERIC Educational Resources Information Center

    EURYDICE Central Unit, Brussels (Belgium).

    The educational systems of the European Community Member States vary considerably and comprise a wealth of information about innovations in these nations. Tables on the employment and status of teachers in state schools in the European Community were compiled at the request of the Commission of the European Communities. The information collected…

  6. Working on European Social Policy. A Report on the Forum (Brussels, Belgium, March 27-30, 1996).

    ERIC Educational Resources Information Center

    Commission of the European Communities, Brussels (Belgium). Directorate-General for Employment, Industrial Relations and Social Affairs.

    This report contains summaries of papers and discussions from a conference at which about 1,000 people representing Nongovernmental Organizations (NGOs), the social partners, and the European Commission gathered to debate and broaden the scope of the interaction between the commission and other European Union institutions and those involved at the…

  7. 47 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Commission. The Federal Communications Commission is composed of five (5) members who are appointed by the president subject to confirmation by the Senate. Normally, one Commissioner is appointed or reappointed each...

  8. Blue Ribbon Commission Tour of Hanford Site

    SciTech Connect

    Paul Saueressig

    2010-07-14

    The Blue Ribbon Commission on America's Nuclear Future toured the Department of Energy's Hanford Site on July 14, 2010. Commission members, invited guests, and members of the public visited facilities that store high-level, radioactive waste.

  9. Blue Ribbon Commission Tour of Hanford Site

    ScienceCinema

    Paul Saueressig

    2016-07-12

    The Blue Ribbon Commission on America's Nuclear Future toured the Department of Energy's Hanford Site on July 14, 2010. Commission members, invited guests, and members of the public visited facilities that store high-level, radioactive waste.

  10. High order WENO and DG methods for time-dependent convection-dominated PDEs: A brief survey of several recent developments

    NASA Astrophysics Data System (ADS)

    Shu, Chi-Wang

    2016-07-01

    For solving time-dependent convection-dominated partial differential equations (PDEs), which arise frequently in computational physics, high order numerical methods, including finite difference, finite volume, finite element and spectral methods, have been undergoing rapid developments over the past decades. In this article we give a brief survey of two selected classes of high order methods, namely the weighted essentially non-oscillatory (WENO) finite difference and finite volume schemes and discontinuous Galerkin (DG) finite element methods, emphasizing several of their recent developments: bound-preserving limiters for DG, finite volume and finite difference schemes, which address issues in robustness and accuracy; WENO limiters for DG methods, which address issues in non-oscillatory performance when there are strong shocks, and inverse Lax-Wendroff type boundary treatments for finite difference schemes, which address issues in solving complex geometry problems using Cartesian meshes.

  11. Bioethics commission to review gene patenting

    SciTech Connect

    Rothenburg, L.

    1995-12-01

    In October, in an unexpected development, U.S. President Bill Clinton created a national ethics advisory board, the National Bioethics Advisory Commission (NBAC, Washington, DC), to study both research ethics and the management and use of genetic information. Of particular interest to biotechnology companies and researchers is the fact that the commission`s brief encompasses issues about human gene patenting, a subject not contained in earlier proposals for the commission.

  12. Nuclear Regulatory Commission 1989 Information Digest

    SciTech Connect

    None,

    1989-03-01

    The Nuclear Regulatory Commission 1989 Information Digest provides summary information regarding the US Nuclear Regulatory Commission, its regulatory responsibilities, and areas licensed by the Commission. This is the first of an annual publication for the general use of the NRC staff and is available to the public. The Digest is divided into two parts: the first presents an overview of the US Nuclear Regulatory Commission and the second provides data on NRC commercial nuclear reactor licensees and commercial nuclear power reactors worldwide.

  13. Lactobacillus casei DG and its postbiotic reduce the inflammatory mucosal response: an ex-vivo organ culture model of post-infectious irritable bowel syndrome.

    PubMed

    Compare, Debora; Rocco, Alba; Coccoli, Pietro; Angrisani, Debora; Sgamato, Costantino; Iovine, Barbara; Salvatore, Umberto; Nardone, Gerardo

    2017-04-14

    The evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (PI-IBS) is convincing. Lactobacillus spp. positively affect IBS symptoms, although the mechanisms through which probiotics exert their beneficial effects are largely unknown. The aim of the study is to evaluate the role of Lactobacillus casei DG (LC-DG) and its postbiotic (PB) in modulating the inflammatory/immune-response in PI-IBS in an ex-vivo organ culture model. Ex vivo cultures of ileal and colonic mucosa from 10 PI-IBS, diarrhea predominant subtype (D) patients, and 10 healthy controls (HC) were treated with LPS, LC-DG and PB. Interleukin (IL)-1α, IL-6, IL-8 and IL-10 mRNA levels were assessed by real-time PCR and Toll like receptor 4 (TLR-4) protein expression by Western blotting. At baseline, IL-1α, IL-6 and IL-8 mRNA levels as well as TLR-4 protein expression were significantly higher while IL-10 mRNA levels were lower in PI-IBS D than in HC in both ileum and colon. LC-DG and PB significantly reduced the mRNA levels of pro-inflammatory cytokines and TLR-4 while increased that of IL-10 after LPS stimulation. The protective effect was more pronounced for PB than LC-DG treatment. LC-DG and its PB attenuate the inflammatory mucosal response in an ex-vivo organ culture model of PI-IBS D.

  14. Candidatus Frankia Datiscae Dg1, the Actinobacterial Microsymbiont of Datisca glomerata, Expresses the Canonical nod Genes nodABC in Symbiosis with Its Host Plant.

    PubMed

    Persson, Tomas; Battenberg, Kai; Demina, Irina V; Vigil-Stenman, Theoden; Vanden Heuvel, Brian; Pujic, Petar; Facciotti, Marc T; Wilbanks, Elizabeth G; O'Brien, Anna; Fournier, Pascale; Cruz Hernandez, Maria Antonia; Mendoza Herrera, Alberto; Médigue, Claudine; Normand, Philippe; Pawlowski, Katharina; Berry, Alison M

    2015-01-01

    Frankia strains are nitrogen-fixing soil actinobacteria that can form root symbioses with actinorhizal plants. Phylogenetically, symbiotic frankiae can be divided into three clusters, and this division also corresponds to host specificity groups. The strains of cluster II which form symbioses with actinorhizal Rosales and Cucurbitales, thus displaying a broad host range, show suprisingly low genetic diversity and to date can not be cultured. The genome of the first representative of this cluster, Candidatus Frankia datiscae Dg1 (Dg1), a microsymbiont of Datisca glomerata, was recently sequenced. A phylogenetic analysis of 50 different housekeeping genes of Dg1 and three published Frankia genomes showed that cluster II is basal among the symbiotic Frankia clusters. Detailed analysis showed that nodules of D. glomerata, independent of the origin of the inoculum, contain several closely related cluster II Frankia operational taxonomic units. Actinorhizal plants and legumes both belong to the nitrogen-fixing plant clade, and bacterial signaling in both groups involves the common symbiotic pathway also used by arbuscular mycorrhizal fungi. However, so far, no molecules resembling rhizobial Nod factors could be isolated from Frankia cultures. Alone among Frankia genomes available to date, the genome of Dg1 contains the canonical nod genes nodA, nodB and nodC known from rhizobia, and these genes are arranged in two operons which are expressed in D. glomerata nodules. Furthermore, Frankia Dg1 nodC was able to partially complement a Rhizobium leguminosarum A34 nodC::Tn5 mutant. Phylogenetic analysis showed that Dg1 Nod proteins are positioned at the root of both α- and β-rhizobial NodABC proteins. NodA-like acyl transferases were found across the phylum Actinobacteria, but among Proteobacteria only in nodulators. Taken together, our evidence indicates an Actinobacterial origin of rhizobial Nod factors.

  15. Candidatus Frankia Datiscae Dg1, the Actinobacterial Microsymbiont of Datisca glomerata, Expresses the Canonical nod Genes nodABC in Symbiosis with Its Host Plant

    PubMed Central

    Persson, Tomas; Battenberg, Kai; Demina, Irina V.; Vigil-Stenman, Theoden; Vanden Heuvel, Brian; Pujic, Petar; Facciotti, Marc T.; Wilbanks, Elizabeth G.; O'Brien, Anna; Fournier, Pascale; Cruz Hernandez, Maria Antonia; Mendoza Herrera, Alberto; Médigue, Claudine; Normand, Philippe; Pawlowski, Katharina; Berry, Alison M.

    2015-01-01

    Frankia strains are nitrogen-fixing soil actinobacteria that can form root symbioses with actinorhizal plants. Phylogenetically, symbiotic frankiae can be divided into three clusters, and this division also corresponds to host specificity groups. The strains of cluster II which form symbioses with actinorhizal Rosales and Cucurbitales, thus displaying a broad host range, show suprisingly low genetic diversity and to date can not be cultured. The genome of the first representative of this cluster, Candidatus Frankia datiscae Dg1 (Dg1), a microsymbiont of Datisca glomerata, was recently sequenced. A phylogenetic analysis of 50 different housekeeping genes of Dg1 and three published Frankia genomes showed that cluster II is basal among the symbiotic Frankia clusters. Detailed analysis showed that nodules of D. glomerata, independent of the origin of the inoculum, contain several closely related cluster II Frankia operational taxonomic units. Actinorhizal plants and legumes both belong to the nitrogen-fixing plant clade, and bacterial signaling in both groups involves the common symbiotic pathway also used by arbuscular mycorrhizal fungi. However, so far, no molecules resembling rhizobial Nod factors could be isolated from Frankia cultures. Alone among Frankia genomes available to date, the genome of Dg1 contains the canonical nod genes nodA, nodB and nodC known from rhizobia, and these genes are arranged in two operons which are expressed in D. glomerata nodules. Furthermore, Frankia Dg1 nodC was able to partially complement a Rhizobium leguminosarum A34 nodC::Tn5 mutant. Phylogenetic analysis showed that Dg1 Nod proteins are positioned at the root of both α- and β-rhizobial NodABC proteins. NodA-like acyl transferases were found across the phylum Actinobacteria, but among Proteobacteria only in nodulators. Taken together, our evidence indicates an Actinobacterial origin of rhizobial Nod factors. PMID:26020781

  16. European Cosmic Ray Symposium

    SciTech Connect

    2008-04-01

    13me Symposium qui se déroule du 27 au 31 juillet pour la première fois au Cern. Brian Pattison ouvre la cérémonie et donne la parole à Dr.Ugland (qui représente le DG C.Rubbia excusé) et d'autres intervenants

  17. Commissions, Reports, Reforms, and Educational Policy.

    ERIC Educational Resources Information Center

    Ginsberg, Rick, Ed.; Plank, David N., Ed.

    "Blue-ribbon" commissions are an increasingly common feature of the American political landscape. This book examines the roles that blue-ribbon commissions and their reports have played in educational policymaking. The book begins with a foreword by Paul E. Peterson and an introductory chapter, "Commissions and Change" by Rick Ginsberg and David…

  18. 17 CFR 200.10 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false The Commission. 200.10 Section... The Commission. The Commission is composed of five members, not more than three of whom may be members of the same political party. The members are appointed by the President, with the advice and consent...

  19. 17 CFR 200.10 - The Commission.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false The Commission. 200.10 Section... The Commission. The Commission is composed of five members, not more than three of whom may be members of the same political party. The members are appointed by the President, with the advice and consent...

  20. 16 CFR 1000.1 - The Commission.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false The Commission. 1000.1 Section 1000.1....1 The Commission. (a) The Consumer Product Safety Commission is an independent regulatory agency formed on May 14, 1973, under the provisions of the Consumer Product Safety Act (Pub. L. 92-573, 86 Stat...

  1. 17 CFR 200.10 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false The Commission. 200.10 Section... The Commission. The Commission is composed of five members, not more than three of whom may be members of the same political party. The members are appointed by the President, with the advice and consent...

  2. 45 CFR 2101.10 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false The Commission. 2101.10 Section 2101.10 Public... ORGANIZATION General Organization § 2101.10 The Commission. The Commission is composed of seven members, each of whom is appointed by the President and serves for a period of four years or until his or her...

  3. 16 CFR 1000.1 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false The Commission. 1000.1 Section 1000.1....1 The Commission. (a) The Consumer Product Safety Commission is an independent regulatory agency formed on May 14, 1973, under the provisions of the Consumer Product Safety Act (Pub. L. 92-573, 86 Stat...

  4. 45 CFR 2101.10 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false The Commission. 2101.10 Section 2101.10 Public... ORGANIZATION General Organization § 2101.10 The Commission. The Commission is composed of seven members, each of whom is appointed by the President and serves for a period of four years or until his or her...

  5. 16 CFR 1000.1 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false The Commission. 1000.1 Section 1000.1....1 The Commission. (a) The Consumer Product Safety Commission is an independent regulatory agency formed on May 14, 1973, under the provisions of the Consumer Product Safety Act (Pub. L. 92-573, 86 Stat...

  6. 17 CFR 200.10 - The Commission.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false The Commission. 200.10 Section... The Commission. The Commission is composed of five members, not more than three of whom may be members of the same political party. The members are appointed by the President, with the advice and consent...

  7. 78 FR 44927 - 101st Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-25

    ... From the Federal Register Online via the Government Publishing Office ARCTIC RESEARCH COMMISSION 101st Commission Meeting Notice is hereby given that the U.S. Arctic Research Commission will hold its... presentations concerning Arctic research activities The focus of the meeting will be Arctic research activities...

  8. 32 CFR 9.4 - Commission personnel.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Commission personnel. 9.4 Section 9.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM §...

  9. 32 CFR 9.4 - Commission personnel.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Commission personnel. 9.4 Section 9.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM §...

  10. 32 CFR 9.4 - Commission personnel.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Commission personnel. 9.4 Section 9.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM §...

  11. 32 CFR 9.4 - Commission personnel.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Commission personnel. 9.4 Section 9.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM §...

  12. 32 CFR 9.4 - Commission personnel.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Commission personnel. 9.4 Section 9.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM §...

  13. 77 FR 10004 - CFC-50 Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... MANAGEMENT CFC-50 Commission AGENCY: Office of Personnel Management. ACTION: Establishment of advisory committee. SUMMARY: The CFC-50 Advisory Commission will hold its third and final meeting on March 2, 2012... Federal Campaign (CFC) to ensure its continued growth and success. The Commission is an advisory committee...

  14. 46 CFR 502.161 - Commission's files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Commission's files. 502.161 Section 502.161 Shipping...; Presiding Officers; Evidence § 502.161 Commission's files. Where any matter contained in a tariff, report, or other document on file with the Commission is offered in evidence, such document need not...

  15. 10 CFR 9.105 - Commission procedures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REGULATORY COMMISSION PUBLIC RECORDS Government in the Sunshine Act Regulations § 9.105 Commission procedures... each Commission meeting a portion or portions of which are proposed to be closed to the public pursuant... proposed to be closed to the public, or with respect to any information concerning such series of meetings...

  16. 10 CFR 9.105 - Commission procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGULATORY COMMISSION PUBLIC RECORDS Government in the Sunshine Act Regulations § 9.105 Commission procedures... each Commission meeting a portion or portions of which are proposed to be closed to the public pursuant... proposed to be closed to the public, or with respect to any information concerning such series of meetings...

  17. 10 CFR 9.105 - Commission procedures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGULATORY COMMISSION PUBLIC RECORDS Government in the Sunshine Act Regulations § 9.105 Commission procedures... each Commission meeting a portion or portions of which are proposed to be closed to the public pursuant... proposed to be closed to the public, or with respect to any information concerning such series of meetings...

  18. 10 CFR 9.105 - Commission procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGULATORY COMMISSION PUBLIC RECORDS Government in the Sunshine Act Regulations § 9.105 Commission procedures... each Commission meeting a portion or portions of which are proposed to be closed to the public pursuant... proposed to be closed to the public, or with respect to any information concerning such series of meetings...

  19. 77 FR 39560 - International Joint Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ... International Joint Commission International Joint Commission Invites Public Comment on Upper Great Lakes Report The International Joint Commission (IJC) announced today that it is inviting public comment on the final report of its International Upper Great Lakes Study Board, Lake Superior Regulation:...

  20. 75 FR 18469 - April 2010 Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ...; ] EXECUTIVE OFFICE OF THE PRESIDENT National Commission on Fiscal Responsibility and Reform April 2010...), the National Commission on Fiscal Responsibility and Reform announces the following meeting: Name: National Commission on Fiscal Responsibility and Reform April 2010 Meeting. Time and Date: Tuesday,...

  1. 17 CFR 200.10 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false The Commission. 200.10 Section... The Commission. The Commission is composed of five members, not more than three of whom may be members of the same political party. The members are appointed by the President, with the advice and consent...

  2. 45 CFR 2101.10 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false The Commission. 2101.10 Section 2101.10 Public... ORGANIZATION General Organization § 2101.10 The Commission. The Commission is composed of seven members, each of whom is appointed by the President and serves for a period of four years or until his or her...

  3. 16 CFR 1000.1 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false The Commission. 1000.1 Section 1000.1....1 The Commission. (a) The Consumer Product Safety Commission is an independent regulatory agency formed on May 14, 1973, under the provisions of the Consumer Product Safety Act (Pub. L. 92-573, 86 Stat...

  4. Iowa College Student Aid Commission Case Study

    ERIC Educational Resources Information Center

    Leigh, Rachel A.

    2007-01-01

    The purpose of this descriptive case study was to trace the policy production process of a state agency, the Iowa College Student Aid Commission (Commission), to its function today. This case study relied on a review of federal and state statutes, a news article search, biennium reports of the Commission, and information obtained from the…

  5. 46 CFR 502.161 - Commission's files.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 9 2013-10-01 2013-10-01 false Commission's files. 502.161 Section 502.161 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Hearings; Presiding Officers; Evidence § 502.161 Commission's files. Where any matter contained in a tariff, report...

  6. 29 CFR 1626.15 - Commission enforcement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Commission enforcement. 1626.15 Section 1626.15 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION PROCEDURES-AGE DISCRIMINATION IN EMPLOYMENT ACT § 1626.15 Commission enforcement. (a) As provided in sections 9, 11, 16 and 17 of the Fair Labor Standards Act of 1938, as...

  7. Commissions, Reports, Reforms, and Educational Policy.

    ERIC Educational Resources Information Center

    Ginsberg, Rick, Ed.; Plank, David N., Ed.

    "Blue-ribbon" commissions are an increasingly common feature of the American political landscape. This book examines the roles that blue-ribbon commissions and their reports have played in educational policymaking. The book begins with a foreword by Paul E. Peterson and an introductory chapter, "Commissions and Change" by Rick Ginsberg and David…

  8. 43 CFR 10010.41 - Commission responsibility.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... environmental document may be prepared by the Commission, a joint-lead agency, a contractor selected or approved... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Commission responsibility. 10010.41... MITIGATION AND CONSERVATION COMMISSION POLICIES AND PROCEDURES FOR IMPLEMENTING THE NATIONAL...

  9. Commissioning services and Primary Health Networks.

    PubMed

    Booth, Mark; Boxall, Anne-Marie

    2016-01-01

    Commissioning is set to become a stronger feature in the Australian health system as Primary Health Networks embrace it as a tool for improving population health outcomes. International experience shows that developing into a commissioning organisation is not always easy. Drawing on international experiences of commissioning, as well as those from the Australian hospital sector, will help smooth the path for Primary Health Networks.

  10. 17 CFR 201.57 - Commission review.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Commission review. 201.57... Regulations Pertaining to the Equal Access to Justice Act § 201.57 Commission review. In accordance with the... Division of the Commission may seek review of the initial decision on the fee application, or the...

  11. 39 CFR 3060.42 - Commission review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Commission review. 3060.42 Section 3060.42 Postal... COMPETITIVE PRODUCTS ENTERPRISE § 3060.42 Commission review. (a) Interested persons shall be provided an... documentation. (b) The Commission will review the calculation of the assumed Federal income tax submitted...

  12. 16 CFR 1101.51 - Commission interpretation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Commission interpretation. 1101.51 Section 1101.51 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT Retraction § 1101.51 Commission interpretation. (a)...

  13. 10 CFR 2.1331 - Commission action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Commission action. 2.1331 Section 2.1331 Energy NUCLEAR... for Hearings on License Transfer Applications § 2.1331 Commission action. (a) Upon completion of a hearing, the Commission will issue a written opinion including its decision on the license transfer...

  14. 76 FR 55424 - CFC-50 Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... MANAGEMENT CFC-50 Commission AGENCY: Office of Personnel Management. ACTION: Establishment of advisory committee. SUMMARY: The U.S. Office of Personnel Management announces the establishment of the CFC-50 Advisory Commission. The Commission shall advise the Director of the U.S. Office of Personnel...

  15. Federal Communications Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... [The Regulatory Plan and Unified Agenda of Federal Regulatory and Deregulatory Actions] Part XIX Federal Communications Commission Semiannual Regulatory Agenda ] FEDERAL COMMUNICATIONS COMMISSION (FCC) FEDERAL COMMUNICATIONS COMMISSION 47 CFR Ch. I Unified Agenda of Federal Regulatory and Deregulatory Actions-Fall 2010 AGENCY: Federal...

  16. Safety assessment of food-contact paper and board using a battery of short-term toxicity tests: European union BIOSAFEPAPER project.

    PubMed

    Severin, I; Dahbi, L; Lhuguenot, J-C; Andersson, M A; Hoornstra, D; Salkinoja-Salonen, M; Turco, L; Zucco, F; Stammati, A; Dahlman, O; Castle, L; Savolainen, M; Weber, A; Honkalampi-Hämäläinen, U; Von Wright, A

    2005-10-01

    An European Union (EU)-funded project QLK1-CT-2001-00930 (BIOSAFEPAPER) involves the development, validation and intercalibration of a short-term battery of toxicological tests for the safety assessment of food-contact paper and board. Dissemination of the results to industry, legislators (e.g. DG Consumer Protection, DG Enterprises, DG Research), standardization bodies such as CEN, and consumers will create an agreed risk evaluation procedure. The project involves pre-normative research in order to establish a set of in-vitro cytotoxicity and genotoxicity tests that will be easily adaptable to food-contact fibre-based materials and have endpoints relevant to consumer safety, including sub-lethal cellular events. These tests will be performed on samples representing actual migration conditions from food-contact paper and board with respect to different foodstuffs, and should form an experimental basis for scientifically sound recommendations for a harmonized system of risk evaluation and product testing.

  17. Commissioning Instrument for the GTC

    NASA Astrophysics Data System (ADS)

    Cuevas, S.; Sánchez, B.; Bringas, V.; Espejo, C.; Flores, R.; Chapa, O.; Lara, G.; Chavolla, A.; Anguiano, G.; Arciniega, S.; Dorantes, A.; González, J. L.; Montoya, J. M.; Toral, R.; Hernández, H.; Nava, R.; Devaney, N.; Castro, J.; Cavaller-Marqués, L.

    2005-12-01

    During the GTC integration phase, the Commissioning Instrument (CI) will be a diagnostic tool for performance verification. The CI features four operation modes: imaging, pupil imaging, Curvature WFS, and high resolution Shack-Hartmann WFS. This instrument was built by the Instituto de Astronomía UNAM and the Centro de Ingeniería y Desarrollo Industrial (CIDESI) under GRANTECAN contract after a public bid. In this paper we made a general instrument overview and we show some of the performance final results obtained when the Factory Acceptance tests previous to its transport to La Palma.

  18. Photometric commissioning results from MINERVA

    NASA Astrophysics Data System (ADS)

    Eastman, Jason D.; Swift, Jonathan; Beatty, Thomas G.; Bottom, Michael; Johnson, John; Wright, Jason; McCrady, Nate; Wittenmyer, Robert A.; Riddle, Reed L.; Plavchan, Peter; Muirhead, Philip Steven; Blake, Cullen; Zhao, Ming

    2015-01-01

    MINERVA is a robotic observatory with four 0.7 meter telescopes at Mt. Hopkins, Arizona, dedicated to precise photometry and radial velocity observations of bright, nearby stars for the discovery and characterization of small exoplanets. Here we present the first photometric results from MINERVA during commissioning at our test facility in Pasadena, California, demonstrating sub-millimag precision on 3-5 minute timescales over several hours. These results show that MINERVA is well-equipped to address its secondary science goal of searching for transits of known and newly discovered super-Earth exoplanets detected by radial velocity, including potential detections from the MINERVA spectrograph.

  19. Division J Commission 28: Galaxies

    NASA Astrophysics Data System (ADS)

    Gallagher, John S.; Davies, Roger L.; Courteau, Stéphane; Dekel, Avishai; Franx, Marijn; Jog, Chanda J.; Jogee, Sardha; Nakai, Naomasa; Rubio, Monica; Tacconi, Linda; Terlevich, Elena

    2016-04-01

    IAU Commission 28 (IAU C28: Galaxies) was founded in the late 1930s at which time it had only a small membership (see the historical notes by Sadler et al. 2007). When C28 ended its existence in 2015 there were well over 1000 members on its books. The membership had grown to the point where the effort to keep track of active participants had become a major task. During the C28s tenure 27 IAU Symposia have been devoted to galaxies, the third highest number (Mickaelian 2014)

  20. Spectroscopic commissioning results from MINERVA

    NASA Astrophysics Data System (ADS)

    Eastman, Jason D.; Johnson, Samson; Wang, Sharon; Sliski, David; Wilson, Maurice; Johnson, John A.; McCrady, Nate; Wittenmyer, Robert A.; Wright, Jason; Plavchan, Peter; Blake, Cullen; Beatty, Thomas G.

    2017-01-01

    MINERVA is a robotic observatory with four 0.7 meter telescopes at Mt. Hopkins, Arizona, dedicated to precise photometry and radial velocity observations of bright, nearby stars for the discovery and characterization of small exoplanets. Here we present the first radial velocity results from MINERVA during commissioning at the Fred Lawrence Whipple Observatory in Arizona, demonstrating m/s precision over month-long timescales. These results show that MINERVA is capable of achieving its primary science goal of finding super-Earths around the nearest, brightest stars.

  1. High Quality Power Supply Method for Islanding Microgrid by use of Several Types of DG Systems including Rotating Machines

    NASA Astrophysics Data System (ADS)

    Kikuchi, Takuro; Baba, Jumpei; Kawachi, Shunsuke; Shimoda, Eisuke; Numata, Shigeo; Yamane, Toshihiro; Masada, Eisuke; Nitta, Tanzo

    When a microgrid is operated in the islanding mode, the operator must satisfy the power quality demand by compensating the active and reactive power using several types of distributed power generation (DG) systems. In this paper, a method to stabilize the system frequency fluctuations and voltage fluctuations of the islanding microgrid is suggested. Extending the suggested “combined cascade control method” which can realize the power compensation without interferences between several types of DGs, “hybrid control” strucuture is proposed and negative effects of control and measurement signal delays on a control are reduced. Moreover, a control of the state of charge (SoC) of energy storage devices is added. For the stabilization of the system voltage, the energy storage is driven by “STATCOM model control”. Experiments have been carried out to confirm the effects of these methods by use of the model microgrid system, and satisfying results were received.

  2. Complete genome sequence of Hymenobacter sp. DG25B, a novel bacterium with gamma-radiation resistance isolated from soil in South Korea.

    PubMed

    Kim, Myung Kyum; Joo, Eun Sun; Lee, Seung-Yeol; Lee, Dae Sung; Srinivasan, Sathiyaraj; Jung, Hee-Young

    2016-01-10

    A Gram-negative, rod-shaped, non-motile, gamma and UV radiation resistant bacterium Hymenobacter radioresistens DG25B was isolated from a soil sample collected in South Korea. The complete genome sequence of H. radioresistens DG25B consists of one circular chromosome (3,874,646 bp). The bacterium was isolated from gamma ray irradiated soil and contains the genomic features of enzymes involved in the nucleotide excision repair (NER) pathway that protect the damaged DNA. The genome also contains other genes involved in the efficient removal of double-strand breaks (DSB) caused by the ionizing radiations. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. E-ELT assembly, integration, and technical commissioning plans

    NASA Astrophysics Data System (ADS)

    Gray, P.; Ciattaglia, E.; Dupuy, C.; Gago, F.; Guisard, S.; Marrero, J.; Ridings, R.; Wright, A.

    2016-07-01

    EELT AIV is the activity of assembly, integration and verification of EELT (European Extremely Large Telescope) subsystems to deliver a telescope capable of fulfilling its top-level requirements and ready to start science commissioning, leading to operations. The AIV (Assembly Integration Verification) phase covers all technical activities on Armazones and nearby Paranal Observatory from the moment the sub-systems and components are delivered or accepted on-site (from the responsible sub-system project manager). AIV includes final system tests of the completed telescope (known as "Technical Commissioning") and the installation, alignment and telescope integration of the science instruments. The AIV phase ends with the handover of the completed telescope with installed instruments, to the start of Science Commissioning. Responsibility then passes to the Commissioning team, however the technical resources for debugging and tuning the telescope and instrument will come from a combination of the AIV team working together with the Paranal operations staff. AIV is one of the major technical challenge of E-ELT. The sheer scale and complexity of the telescope involves challenging logistics and scheduling i.e. 798 mirror segments with a staged delivery over four years, including 9,048 edge sensor and 2,394 position actuators. More than ten major sub-systems e.g. M2-3-4-5, PreFocal Station (PFS) and instruments will be integrated and tested in parallel. Finally, the technical commissioning phase will be a significant challenge. E-ELT is a highly complex active telescope system with a fully-integrated adaptive optics (AO) system. During early testing nothing will be straightforward and there will be many system-level problems to overcome. It will take a dedicated team of the "best of the best" people to troubleshoot, debug, tune, and hand over as an operational facility.

  4. Enhanced plasmid DNA utilization in transiently transfected CHO-DG44 cells in the presence of polar solvents.

    PubMed

    Rajendra, Yashas; Balasubramanian, Sowmya; Kiseljak, Divor; Baldi, Lucia; Wurm, Florian M; Hacker, David L

    2015-01-01

    Although the protein yields from transient gene expression (TGE) with Chinese hamster ovary (CHO) cells have recently improved, the amount of plasmid DNA (pDNA) needed for transfection remains relatively high. We describe a strategy to reduce the pDNA amount by transfecting CHO-DG44 cells with 0.06 μg pDNA/10(6) cells (10% of the optimal amount) in the presence of nonspecific (filler) DNA and various polar solvents including dimethylsufoxide, dimethyl formamide, acetonitrile, dimethyl acetamide (DMA), and hexamethyl phosphoramide (HMP). All of the polar solvents with the exception of HMP increased the production of a recombinant antibody in comparison to the untreated control transfection. In the presence of 0.25% DMA, the antibody yield in a 7-day batch culture was 500 mg/L. This was fourfold higher than the yield from the untreated control transfection. Mechanistic studies revealed that the polar solvents did not affect polyethylenimine-mediated pDNA delivery into cells or nuclei. The steady-state transgene mRNA level was elevated in the presence of each of the polar solvents tested, while the transgene mRNA half-life remained the same. These results indicated that the polar solvents enhanced transgene transcription. When screening a panel of recombinant antibodies and Fc-fusion proteins for production in the presence of the polar solvents, the highest increase in yield was observed following DMA addition for 11 of the 12 proteins. These results are expected to enhance the applicability of high-yielding TGE processes with CHO-DG44 cells by decreasing the amount of pDNA required for transfection.

  5. Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence.

    PubMed

    Tilly, Peggy; Charles, Anne-Laure; Ludwig, Sophie; Slimani, Farid; Gross, Sabrina; Meilhac, Olivier; Geny, Bernard; Stefansson, Kari; Gurney, Mark E; Fabre, Jean-Etienne

    2014-03-01

    Haemostasis interrupts bleeding from disrupted blood vessels by activating platelet aggregation and coagulation. A similar mechanism termed thrombosis generates obstructive thrombi inside diseased arteries. As a consequence of this similarity, current anti-thrombotic agents increase the risk of bleeding. Atherosclerotic plaques produce significant amounts of prostaglandin E2 (PGE2), which activates its receptor EP3 on platelets and aggravates atherothrombosis. We investigated whether blocking EP3 could dissociate atherothrombosis from haemostasis. Inhibiting in vivo the receptor EP3 for PGE2 with the blocking agent DG-041 reduced murine thrombosis triggered by local delivery of arachidonic acid or ferric chloride on healthy arteries. Importantly, it also reduced thrombosis triggered by scratching murine atherosclerotic plaques. PGE2 was not produced at the bleeding site after tail clipping. Consistently, blocking EP3 did not alter murine tail, liver, or cerebral haemostasis. Furthermore, blocking EP3 reduced murine pulmonary embolism and intensified platelet inhibition by clopidogrel leaving tail bleeding times unchanged. Human atherosclerotic plaques produced PGE2, which facilitated platelet aggregation in human blood and rescued the function of P2Y12-blocked platelets. Finally, in healthy patients, DG-041 reduced platelet aggregation, but did not significantly alter the cutaneous bleeding time at doses up to eight times the dose that inhibited the facilitating effect of PGE2 on platelets. In mice, blocking EP3 inhibited atherothrombosis without affecting haemostasis and intensified efficiency of conventional anti-platelet treatment without aggravating the bleeding risk. In patients, blocking EP3 should improve the prevention of cardiovascular diseases, which is currently limited by the risk of bleeding.

  6. Beyond Commissioning: The Role of Automation

    SciTech Connect

    Brambley, Michael R.; Katipamula, Srinivas

    2005-02-01

    This article takes a brief look at the benefits of commissioning and describes a vision of the future where most of the objectives of commissioning will be accomplished automatically by capabilities built into the building systems themselves. Commissioning will become an activity that's performed continuously rather than periodically, and only repairs requiring replacement or overhaul of equipment will require manual intervention. The article then identifies some of the technologies that will be needed to realize this vision and ends with a call for all involved in the enterprise of building commissioning and automation to embrace and dedicate themselves to a future of automated commissioning.

  7. 75 FR 11166 - Joint Meeting of the Nuclear Regulatory Commission and the Federal Energy Regulatory Commission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Joint Meeting of the Nuclear Regulatory Commission and the Federal Energy Regulatory Commission; Notice of Joint Meeting of the Nuclear Regulatory Commission and the...

  8. 47 CFR 51.803 - Procedures for Commission notification of a state commission's failure to act.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the state commission and the other parties to the proceeding or matter for which preemption is sought... commission and the parties to a proceeding or matter in which the Commission has taken notice of the state... determining whether it is required to preempt the state commission's jurisdiction of a proceeding or matter...

  9. Division A Commission 31: Time

    NASA Astrophysics Data System (ADS)

    Hosokawa, Mizuhiko; Arias, Elisa Felicitas; Manchester, Richard; Tuckey, Philip; Matsakis, Demetrios; Zhang, Shougang; Zharov, Vladimir

    2016-04-01

    Time is an essential element of fundamental astronomy. In recent years there have been many time-related issues, in scientific and technological aspects as well as in conventions and definitions. At the Commission 31 (Time) business meeting at the XXIX General Assembly, recent progress and many topics, including Pulsar Time Scales WG and Future UTC WG activities, were reviewed and discussed. In this report, we will review the progress of these topics in the past three years. There are many remarkable topics, such as Time scales, Atomic clock development, Time transfer, Future UTC and future redefinition of the second. Among them, scientific highlights are the progress of pulsar time scales and the optical frequency standards. On the other hand, as the social convention, change in the definition of UTC and the second is important.

  10. Automated Demand Response and Commissioning

    SciTech Connect

    Piette, Mary Ann; Watson, David S.; Motegi, Naoya; Bourassa, Norman

    2005-04-01

    This paper describes the results from the second season of research to develop and evaluate the performance of new Automated Demand Response (Auto-DR) hardware and software technology in large facilities. Demand Response (DR) is a set of activities to reduce or shift electricity use to improve the electric grid reliability and manage electricity costs. Fully-Automated Demand Response does not involve human intervention, but is initiated at a home, building, or facility through receipt of an external communications signal. We refer to this as Auto-DR. The evaluation of the control and communications must be properly configured and pass through a set of test stages: Readiness, Approval, Price Client/Price Server Communication, Internet Gateway/Internet Relay Communication, Control of Equipment, and DR Shed Effectiveness. New commissioning tests are needed for such systems to improve connecting demand responsive building systems to the electric grid demand response systems.

  11. ACCUMULATION OF M1DG DNA ADDUCTS AFTER CHRONIC EXPOSURE TO PCBS, BUT NOT FROM ACUTE EXPOSURE TO DIOXIN-LIKE COMPOUNDS

    EPA Science Inventory

    ABSTRACT: Oxidative DNA damage is one of the key events leading to mutation and cancer. The present study examined the accumulation of M1dG DNA adducts, 3-(2’-deoxy-β-D-erythro-pentofuranosyl)-pyrimido[1,2-a]-purin-10(3H)-one, after single or yearly exposur...

  12. ACCUMULATION OF M1DG DNA ADDUCTS AFTER CHRONIC EXPOSURE TO PCBS, BUT NOT FROM ACUTE EXPOSURE TO DIOXIN-LIKE COMPOUNDS

    EPA Science Inventory

    ABSTRACT: Oxidative DNA damage is one of the key events leading to mutation and cancer. The present study examined the accumulation of M1dG DNA adducts, 3-(2’-deoxy-β-D-erythro-pentofuranosyl)-pyrimido[1,2-a]-purin-10(3H)-one, after single or yearly exposur...

  13. A multi-dimensional high-order DG-ALE method based on gas-kinetic theory with application to oscillating bodies

    NASA Astrophysics Data System (ADS)

    Ren, Xiaodong; Xu, Kun; Shyy, Wei

    2016-07-01

    This paper presents a multi-dimensional high-order discontinuous Galerkin (DG) method in an arbitrary Lagrangian-Eulerian (ALE) formulation to simulate flows over variable domains with moving and deforming meshes. It is an extension of the gas-kinetic DG method proposed by the authors for static domains (X. Ren et al., 2015 [22]). A moving mesh gas kinetic DG method is proposed for both inviscid and viscous flow computations. A flux integration method across a translating and deforming cell interface has been constructed. Differently from the previous ALE-type gas kinetic method with piecewise constant mesh velocity at each cell interface within each time step, the mesh velocity variation inside a cell and the mesh moving and rotating at a cell interface have been accounted for in the finite element framework. As a result, the current scheme is applicable for any kind of mesh movement, such as translation, rotation, and deformation. The accuracy and robustness of the scheme have been improved significantly in the oscillating airfoil calculations. All computations are conducted in a physical domain rather than in a reference domain, and the basis functions move with the grid movement. Therefore, the numerical scheme can preserve the uniform flow automatically, and satisfy the geometric conservation law (GCL). The numerical accuracy can be maintained even for a largely moving and deforming mesh. Several test cases are presented to demonstrate the performance of the gas-kinetic DG-ALE method.

  14. Jacobian-Free Newton-Krylov Discontinuous Galerkin (JFNK-DG) Method and Its Physics-Based Preconditioning for All-Speed Flows

    NASA Astrophysics Data System (ADS)

    Park, Hyeongkae; Nourgaliev, Robert; Knoll, Dana

    2007-11-01

    The Discontinuous Galerkin (DG) method for compressible fluid flows is incorporated into the Jacobian-Free Newton-Krylov (JFNK) framework. Advantages of combining the DG with the JFNK are two-fold: a) enabling robust and efficient high-order-accurate modeling of all-speed flows on unstructured grids, opening the possibility for high-fidelity simulation of nuclear-power-industry-relevant flows; and b) ability to tightly, robustly and high-order-accurately couple with other relevant physics (neutronics, thermal-structural response of solids, etc.). In the present study, we focus on the physics-based preconditioning (PBP) of the Krylov method (GMRES), used as the linear solver in our implicit higher-order-accurate Runge-Kutta (ESDIRK) time discretization scheme; exploiting the compactness of the spatial discretization of the DG family. In particular, we utilize the Implicit Continuous-fluid Eulerian (ICE) method and investigate its efficacy as the PBP within the JFNK-DG method. Using the eigenvalue analysis, it is found that the ICE collapses the complex components of the all eigenvalues of the Jacobian matrix (associated with pressure waves) onto the real axis, and thereby enabling at least an order of magnitude faster simulations in nearly-incompressible/weakly-compressible regimes with a significant storage saving.

  15. Notice of Release of WhiteAcre-DG, a Small-seeded, Cream-type Southernpea with an Enhanced Persistent Green Seed Phenotype

    USDA-ARS?s Scientific Manuscript database

    The USDA has developed a high yielding, small-seeded, cream-type southernpea cultivar that has a persistent green seed phenotype conditioned by both the green cotyledon gene (gc) and the green testa gene (gt). The new cultivar, named WhiteAcre-DG, can be harvested at the dry-pod stage of maturity w...

  16. Overexpression of a novel chrysanthemum Cys2/His2-type zinc finger protein gene DgZFP3 confers drought tolerance in tobacco.

    PubMed

    Liu, Qing-Lin; Xu, Ke-Dong; Zhong, Ming; Pan, Yuan-Zhi; Jiang, Bei-Bei; Liu, Guang-Li; Jia, Yin; Zhang, Hai-Qing

    2013-11-01

    A drought stress-responsive Cys2/His2-type zinc finger protein gene DgZFP3 was previously isolated (Liu et al., Afr J Biotechnol 11:7781-7788, 2012b) from chrysanthemum. To assess roles of DgZFP3 in plant drought stress responses, we performed gain-of-function experiment. The DgZFP3-overexpression tobacco plants showed significant drought tolerance over the wild type (WT). The transgenic lines exhibited less accumulation of H2O2 under drought stress, more accumulation of proline and greater activities of peroxidase (POD) and superoxide dismutase than the WT under both control conditions and drought stress. In addition, there was greater up-regulation of the ROS-related enzyme genes (NtSOD and NtPOD) and stress-related genes (NtLEA5 and NtDREB) in transgenic lines under normal or drought conditons. Thus DgZFP3 probably plays a positive regulatory role in drought stress response and has the potential to be utilized in transgenic breeding to improve drought stress tolerance in plants.

  17. Orion: a commissioned user facility

    NASA Astrophysics Data System (ADS)

    Treadwell, P. A.; Allan, P.; Cann, N.; Danson, C.; Duffield, S.; Elsmere, S.; Edwards, R.; Egan, D.; Girling, M.; Gumbrell, E.; Harvey, E.; Hill, M.; Hillier, D.; Hoarty, D.; Hobbs, L.; Hopps, N.; Hussey, D.; Oades, K.; James, S.; Norman, M.; Palmer, J.; Parker, S.; Winter, D.; Bett, T.

    2013-05-01

    The Orion Laser Facility at AWE in the UK consists of ten nanosecond beamlines and two sub-picosecond beamlines. The nanosecond beamlines each nominally deliver 500 J at 351 nm in a 1 ns square temporal profile, but can also deliver a user-definable temporal profile with durations between 0.1 ns and 5 ns. The sub-picosecond beamlines each nominally deliver 500 J at 1053 nm in a 500 fs pulse, with a peak irradiance of greater than 1021 W/cm2. One of the sub-picosecond beamlines can also be frequency-converted to deliver 100 J at 527 nm in a 500 fs pulse, although this is at half the aperture of the 1053 nm beam. Commissioning of all twelve beamlines has been completed, including the 527 nm sub-picosecond option. An overview of the design of the Orion beamlines will be presented, along with a summary of the commissioning and subsequent performance data. The design of Orion was underwritten by running various computer simulations of the beamlines. Work is now underway to validate these simulations against real system data, with the aim of creating predictive models of beamline performance. These predictive models will enable the user's experimental requirements to be critically assessed ahead of time, and will ultimately be used to determine key system settings and parameters. The facility is now conducting high energy density physics experiments. A capability experiment has already been conducted that demonstrates that Orion can generate plasmas at several million Kelvin and several times solid density. From March 2013 15% of the facility operating time will be given over to external academic users in addition to collaborative experiments with AWE scientists.

  18. Transcriptional analysis of degenerate strain Clostridium beijerinckii DG-8052 reveals a pleiotropic response to CaCO3-associated recovery of solvent production

    PubMed Central

    Jiao, Shengyin; Zhang, Yan; Wan, Caixia; Lv, Jia; Du, Renjia; Zhang, Ruijuan; Han, Bei

    2016-01-01

    Degenerate Clostridium beijerinckii strain (DG-8052) can be partially recovered by supplementing CaCO3 to fermentation media. Genome resequencing of DG-8052 showed no general regulator mutated. This study focused on transcriptional analysis of DG-8052 and its response to CaCO3 treatment via microarray. The expressions of 5168 genes capturing 98.6% of C. beijerinckii NCIMB 8052 genome were examed. The results revealed that with addition of CaCO3 565 and 916 genes were significantly up-regulated, and 704 and 1044 genes significantly down-regulated at acidogenic and solventogenic phase of DG-8052, respectively. These genes are primarily responsible for glycolysis to solvent/acid production (poR, pfo), solventogensis (buk, ctf, aldh, adh, bcd) and sporulation (spo0A, sigE, sigma-70, bofA), cell motility and division (ftsA, ftsK, ftsY, ftsH, ftsE, mreB, mreC, mreD, rodA), and molecular chaperones (grpE, dnaK, dnaJ, hsp20, hsp90), etc. The functions of some altered genes in DG-8052, totalling 5.7% at acidogenisis and 8.0% at sovlentogenisis, remain unknown. The response of the degenerate strain to CaCO3 was suggested significantly pleiotropic. This study reveals the multitude of regulatory function that CaCO3 has in clostridia and provides detailed insights into degeneration mechanisms at gene regulation level. It also enables us to develop effective strategies to prevent strain degeneration in future. PMID:27966599

  19. Physical properties of the jet from DG Tauri on sub-arcsecond scales with HST/STIS

    NASA Astrophysics Data System (ADS)

    Maurri, L.; Bacciotti, F.; Podio, L.; Eislöffel, J.; Ray, T. P.; Mundt, R.; Locatelli, U.; Coffey, D.

    2014-05-01

    Context. Stellar jets are believed to play a key role in star formation, but the question of how they originate is still being debated. Aims: We derive the physical properties at the base of the jet from DG Tau both along and across the flow and as a function of velocity. Methods: We analysed seven optical spectra of the DG Tau jet, taken with the Hubble Space Telescope Imaging Spectrograph. The spectra were obtained by placing a long-slit parallel to the jet axis and stepping it across the jet width. The resulting position-velocity diagrams in optical forbidden emission lines allowed access to plasma conditions via calculation of emission line ratios. In this way, we produced a 3D map (2D in space and 1D in velocity) of the jet's physical parameters i.e. electron density ne, hydrogen ionisation fraction xe, and total hydrogen density nH. The method used is a new version of the BE-technique. Results: A fundamental improvement is that the new diagnostic method allows us to overcome the upper density limit of the standard [S ii] diagnostics. As a result, we find at the base of the jet high electron density, ne ~ 105, and very low ionisation, xe ~ 0.02-0.05, which combine to give a total density up to nH ~ 3 × 106. This analysis confirms previous reports of variations in plasma parameters along the jet, (i.e. decrease in density by several orders of magnitude, increase of xe from 0.05 to a plateau at 0.7 downstream at 2'' from the star). Furthermore, a spatial coincidence is revealed between sharp gradients in the total density and supersonic velocity jumps. This strongly suggests that the emission is caused by shock excitation. No evidence was found of variations in the parameters across the jet, within a given velocity interval. The position-velocity diagrams indicate the presence of both fast accelerating gas and slower, less collimated material. We derive the mass outflow rate, Ṁj, in the blue-shifted lobe in different velocity channels, that contribute to a

  20. 78 FR 44165 - Nuclear Regulatory Commission Enforcement Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Nuclear Regulatory Commission Enforcement Policy AGENCY: Nuclear Regulatory Commission. ACTION: Enforcement policy; request for comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is...

  1. VLT Commissioning Data Now Publicly Available

    NASA Astrophysics Data System (ADS)

    1999-11-01

    "First Light" was achieved in May 1998 for VLT ANTU , the first 8.2-m Unit Telescope at the Paranal Observatory ( ESO PR 06/98 ). Since then, thousands of detailed images and spectra of a great variety of celestial objects have been recorded with this major new research facility. While some of these were obtained for scientific programmes and were therefore directed towards specific research needs, others were made during the "Commissioning Phases" in 1998/99 for the two major astronomical instruments, FORS1 ( FO cal R educer and S pectrograph) and ISAAC ( I nfrared S pectrometer A nd A rray C amera). They were carried out in order to test thoroughly the performance of the telescope and its instruments before the new facility was handed over to the astronomers on April 1, 1999. The Commissioning data are accordingly of variable quality and, contrarily to the science data, normally not intensity calibrated. However, while some of these frames are short test exposures that mainly served to ascertain the image quality under various observing conditions, a substantial fraction still contains scientifically valuable data. 10 Gigabytes released As planned, and in order to facilitate the exploitation of this useful material, ESO has today released over 10 Gigabytes of ANTU Commissioning data (and some additional test data from before April 1, 1999), obtained in the various observing modes of FORS1 and ISAAC . They encompass a total of 2235 files and are now available to astronomers and other interested parties in the ESO Member States. Information about this release and on how to obtain the data on CD-ROM or in electronic form is now available via the Science Archive Facility website. A special page with the list of raw science data frames included in this release has been set up. Searches for specific data (e.g., by object, sky field, filter, time of observation; calibration files, etc.) can be made from the ESO Science Archive Data Products page. These Commissioning

  2. Commissioning Results on the JWST Testbed Telescope

    NASA Technical Reports Server (NTRS)

    Dean, Bruce H.; Acton, D. Scott

    2006-01-01

    The one-meter 18 segment JWST Testbed Telescope (TBT) has been developed at Ball Aerospace to facilitate commissioning operations for the JWST Observatory. Eight different commissioning activities were tested on the TBT: telescope focus sweep, segment ID and Search, image array, global alignment, image stacking, coarse phasing, fine phasing, and multi-field phasing. This paper describes recent commissioning results from experiments performed on the TBT.

  3. SNS BEAM COMMISSIONING TOOLS AND EXPERIENCE

    SciTech Connect

    Shishlo, Andrei P; Galambos, John D

    2008-01-01

    The Spallation Neutron Source (SNS) successfully met the primary construction project completion milestones in April 2006. An important ingredient of this successful commissioning was the development and use of software tools. With the increasing digitalization of beam diagnostics and increasing complexity of Integrated Control Systems of large accelerators, the need for high level software tools is critical for smooth commissioning. At SNS a special Java based infrastructure called XAL was prepared for beam commissioning. XAL provides a hierarchal view of the accelerator, is data base configured, and includes a physics model of the beam. This infrastructure and individual applications development along with a historical time line of the SNS commissioning will be discussed.

  4. European Cosmic Ray Symposium

    ScienceCinema

    None

    2016-07-12

    13me Symposium qui se déroule du 27 au 31 juillet pour la première fois au Cern. Brian Pattison ouvre la cérémonie et donne la parole à Dr.Ugland (qui représente le DG C.Rubbia excusé) et d'autres intervenants

  5. VIRUS early installation and commissioning

    NASA Astrophysics Data System (ADS)

    Tuttle, Sarah E.; Hill, Gary J.; Vattiat, Brian L.; Lee, Hanshin; Drory, Niv; Kelz, Andreas; Ramsey, Jason; Peterson, Trent; Noyola, Eva; DePoy, Darren L.; Marshall, Jennifer L.; Chonis, Taylor S.; Dalton, Gavin; Fabricius, Maximilian; Farrow, Daniel; Good, John M.; Haynes, Dionne M.; Indahl, Briana; Jahn, Thomas; Kriel, Hermanus; Nicklas, Harald; Montesano, Francesco; Prochaska, Travis; Allen, Richard D.; Landriau, Martin; MacQueen, Phillip J.; Roth, Martin M.; Savage, Richard; Snigula, Jan M.

    2016-08-01

    VIRUS is a massively replicated spectrograph built for HETDEX, the Hobby Eberly Telescope Dark Energy Experiment. It consists of 156 channels within 78 units fed by 34944 fibers over the 22 arcminute field of the upgraded HET. VIRUS covers a relatively narrow bandpass (350-550nm) at low resolution (R 700) to target the emission of Lyman-alpha emitters (LAEs) for HETDEX. VIRUS is a first demonstration of industrial style assembly line replication in optical astronomy. Installation and testing of VIRUS units began in November of 2015. This winter we celebrated the first on sky instrument activity of the upgraded HET, using a VIRUS unit and LRS2-R (the upgraded facility Low Resolution Spectrograph for the HET). Here we describe progress in VIRUS installation and commissioning through June 2016. We include early sky data obtained to characterize spectrograph performance and on sky performance of the newly upgraded HET. As part of the instrumentation for first science light at the HET, the IFU fed spectrographs were used to test a full range of telescope system functionality including the field calibration unit (FCU).We also use placement of strategic IFUs to map the new HET field to the fiber placement, and demonstrate actuation of the dithering mechanism key to HETDEX observations.

  6. Commission 42: Close Binary Stars

    NASA Astrophysics Data System (ADS)

    Ribas, Ignasi; Richards, Mercedes T.; Rucinski, Slavek; Bradstreet, David H.; Harmanec, Petr; Kaluzny, Janusz; Mikolajewska, Joanna; Munari, Ulisse; Niarchos, Panagiotis; Olah, Katalin; Pribulla, Theodor; Scarfe, Colin D.; Torres, Guillermo

    2012-04-01

    The present report covers the main developments in the field of close binaries during the triennium 2009-2012. In addition to scientific publications, there have been several opportunities for direct interaction of researchers working on close binaries. A number of meetings focused on more or less specific topics have taken place during this past years but the highlight for Commission 42 is arguably IAU Symposium 282 held in 2011 in Slovakia. The meeting exploited a strong connection in the methodology and tools used by close binary studies and the rapidly advancing field of exoplanet research. After all, exoplanetary systems are mostly discovered and studied using techniques employed by analyses of close binaries for decades. Modelling of exoplanet radial velocity curves and transiting planet light curves are just particular cases of single-lined and eclipsing binary systems, respectively, with very unequal component properties. As shown by IAU Symposium 282, the synergies between the two fields are strong and potentially very useful. Found below is a summary of the main scientific topics and conclusions from this very successful Symposium.

  7. Drain Current Model for Double Gate (DG) p-n-i-n TFET: Accumulation to Inversion Region of Operation

    NASA Astrophysics Data System (ADS)

    Upasana; Narang, Rakhi; Saxena, Manoj; Gupta, Mridula

    2017-04-01

    In this paper, drain current model has been formulated for Double Gate (DG) p-n-i-n Tunnel FET (TFET) using Lambert-W function. The model includes the impact of mobile charges, gate dielectric thickness (tox) and channel thickness (tsi) on quasi fermi level, gate threshold voltage (VTG), onset voltage (VGonset) and Tunneling Barrier Width (TBW) over the entire operating range i.e. accumulation to inversion state. Important electrostatic and electrical parameters such as the effective potential (φeffective) at the center of the channel, 2-D channel potential, electric field, energy band profile and Tunneling Barrier Width (TBW) dependent drain current have been modeled. Moreover, gate and drain bias controllability in different operating regimes has also been investigated by varying oxide thickness (tox), channel thickness (tsi), intrinsic channel length (Lint) and at different temperatures. Important FOMs required for analog circuit performance such as transconductance (gm), drain conductance (gd), output resistance (Rout), early voltage (VEA) have also been evaluated and verified using ATLAS device simulation software.

  8. Simulating Large-Scale Earthquake Dynamic Rupture Scenarios On Natural Fault Zones Using the ADER-DG Method

    NASA Astrophysics Data System (ADS)

    Gabriel, Alice; Pelties, Christian

    2014-05-01

    In this presentation we will demonstrate the benefits of using modern numerical methods to support physic-based ground motion modeling and research. For this purpose, we utilize SeisSol an arbitrary high-order derivative Discontinuous Galerkin (ADER-DG) scheme to solve the spontaneous rupture problem with high-order accuracy in space and time using three-dimensional unstructured tetrahedral meshes. We recently verified the method in various advanced test cases of the 'SCEC/USGS Dynamic Earthquake Rupture Code Verification Exercise' benchmark suite, including branching and dipping fault systems, heterogeneous background stresses, bi-material faults and rate-and-state friction constitutive formulations. Now, we study the dynamic rupture process using 3D meshes of fault systems constructed from geological and geophysical constraints, such as high-resolution topography, 3D velocity models and fault geometries. Our starting point is a large scale earthquake dynamic rupture scenario based on the 1994 Northridge blind thrust event in Southern California. Starting from this well documented and extensively studied event, we intend to understand the ground-motion, including the relevant high frequency content, generated from complex fault systems and its variation arising from various physical constraints. For example, our results imply that the Northridge fault geometry favors a pulse-like rupture behavior.

  9. Energy Shortage Contingency Plan. (California Energy Commission)

    SciTech Connect

    Not Available

    1994-03-01

    The California Energy Commission's 1993 Energy Shortage Contingency Plan is prepared in response to state legislative requirements. The statute directs the California Energy Commission to prepare and submit to the Governor and Legislature contingency plans to deal with possible shortages of electrical energy or fuel supplies to protect public health, safety and welfare.

  10. Commissioning MMS: Challenges and Lessons Learned

    NASA Technical Reports Server (NTRS)

    Wood, Paul; Gramling, Cheryl; Reiter, Jennifer; Smith, Patrick; Stone, John

    2016-01-01

    This paper discusses commissioning of NASA's Magnetospheric MultiScale (MMS) Mission. The mission includes four identical spacecraft with a large, complex set of instrumentation. The planning for and execution of commissioning for this mission is described. The paper concludes by discussing lessons learned.

  11. The Commission on Rural Colleges: A Beginning.

    ERIC Educational Resources Information Center

    McCoy, William H.

    1979-01-01

    Describes the establishment by the American Association of Community and Junior Colleges of the Task Force on Rural Community Colleges and the subsequent establishment of the more permanent Commission on Rural Colleges. Delineates its membership, activities, and areas which need to be acted upon by the Commission. (MB)

  12. 2005 Base Closure and Realignment Commission Report

    EPA Pesticide Factsheets

    The 2005 Defense Base Closure and Realignment Commission is proud to present its Final Report for your consideration. As required by law, the Commission thoroughly and objectively reviewed the domestic installation closure and realignment recommendations proposed by the Secretary of Defense on May 13, 2005.

  13. 10 CFR 2.1331 - Commission action.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Commission action. 2.1331 Section 2.1331 Energy NUCLEAR REGULATORY COMMISSION AGENCY RULES OF PRACTICE AND PROCEDURE Procedures for Hearings on License Transfer... opinion including its decision on the license transfer application and the reasons for the decision....

  14. 10 CFR 2.1331 - Commission action.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Commission action. 2.1331 Section 2.1331 Energy NUCLEAR REGULATORY COMMISSION AGENCY RULES OF PRACTICE AND PROCEDURE Procedures for Hearings on License Transfer... opinion including its decision on the license transfer application and the reasons for the decision....

  15. 44 CFR 62.6 - Minimum commissions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADJUSTMENT OF CLAIMS Issuance of Policies § 62.6 Minimum commissions. (a) The earned commission which shall be paid to any property or casualty insurance agent or broker duly licensed by a state insurance regulatory authority, with respect to each policy or renewal the agent duly procures on behalf of the...

  16. MCCONE COMMISSION EDUCATION RECOMMENDATIONS. PROGRESS REPORT.

    ERIC Educational Resources Information Center

    MARTYN, KENNETH A.

    THIS FOLLOWUP STUDY EXAMINES THE PROGRESS OF THE LOS ANGELES CITY AND COUNTY SCHOOLS IN IMPLEMENTING THE EDUCATIONAL RECOMMENDATIONS IN THE REPORT OF THE MCCONE COMMISSION, THE GOVERNOR'S COMMISSION ON THE LOS ANGELES RIOTS. IT PRESENTS DATA, SUPPLIED BY THE ADMINISTRATIVE STAFF OF THE SCHOOL DISTRICTS, ON DOUBLE SESSIONS AND UNUSED CLASSROOMS,…

  17. 38 CFR 13.64 - Fiduciary commissions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Fiduciary commissions. 13.64 Section 13.64 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS VETERANS BENEFITS ADMINISTRATION, FIDUCIARY ACTIVITIES § 13.64 Fiduciary commissions. Generally, a VA appointed...

  18. 38 CFR 13.64 - Fiduciary commissions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Fiduciary commissions. 13.64 Section 13.64 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS VETERANS BENEFITS ADMINISTRATION, FIDUCIARY ACTIVITIES § 13.64 Fiduciary commissions. Generally, a VA appointed...

  19. Wyoming Community College Commission Annual Report, 2010

    ERIC Educational Resources Information Center

    Wyoming Community College Commission, 2010

    2010-01-01

    The Wyoming Community College Commission (WCCC) serves the system of Wyoming's seven community colleges. Wyoming's seven community colleges provide affordable, accessible and lifelong education. The Wyoming Community College Commission supports the colleges through advocacy, coordination and collaboration. In partnership with the colleges, the…

  20. 18 CFR 35.31 - Commission review.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... determine whether the ASC set by BPA for the applicable exchange period was determined in accordance with... Commission will order that BPA amend the ASC to conform with the methodology. If the ASC is in accord with... by the Commission will be at the rate charged to BPA by the U.S. Treasury during that period,...

  1. 18 CFR 35.31 - Commission review.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... determine whether the ASC set by BPA for the applicable exchange period was determined in accordance with... Commission will order that BPA amend the ASC to conform with the methodology. If the ASC is in accord with... by the Commission will be at the rate charged to BPA by the U.S. Treasury during that period,...

  2. 18 CFR 35.31 - Commission review.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... determine whether the ASC set by BPA for the applicable exchange period was determined in accordance with... Commission will order that BPA amend the ASC to conform with the methodology. If the ASC is in accord with... by the Commission will be at the rate charged to BPA by the U.S. Treasury during that period,...

  3. 18 CFR 35.31 - Commission review.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... determine whether the ASC set by BPA for the applicable exchange period was determined in accordance with... Commission will order that BPA amend the ASC to conform with the methodology. If the ASC is in accord with... by the Commission will be at the rate charged to BPA by the U.S. Treasury during that period,...

  4. 18 CFR 35.31 - Commission review.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... determine whether the ASC set by BPA for the applicable exchange period was determined in accordance with... Commission will order that BPA amend the ASC to conform with the methodology. If the ASC is in accord with... by the Commission will be at the rate charged to BPA by the U.S. Treasury during that period,...

  5. 18 CFR 375.101 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Commission is at 888 First Street, NE., Washington, DC 20426. Regional offices are maintained at Atlanta, GA... the United States. The time and place of meetings of the Commission are announced in advance as... members or by such agents as it may designate, conduct any hearing, or other inquiry necessary...

  6. Alaska Women's Commission Regional Conferences 1986.

    ERIC Educational Resources Information Center

    Callahan, Christine

    This booklet describes the work of the Alaska Women's Commission, a state agency dedicated to the achievement of equal legal, economic, social, and political status for women in Alaska. Since its inception, the Alaska Women's Commission has provided funding for regional women's conferences in rural parts of the state. The document describes four…

  7. Commission on Preservation and Access Newsletter, 1995.

    ERIC Educational Resources Information Center

    Commission on Preservation and Access Newsletter, 1995

    1995-01-01

    The Commission on Preservation and Access was established to foster and support collaboration among libraries and allied organizations in order to ensure the preservation of the published and documentary records in all formats and to provide enhanced access to scholarly information. The Commission's newsletter keeps preservation and access…

  8. CCRIS: Carnegie Commission Reports Information System.

    ERIC Educational Resources Information Center

    Lavin, Mary Jo

    The Carnegie Commission Reports Information System (CCRIS) attempts to make the findings of the 22 Commission reports (published by McGraw Hill Book Company) more readily available to the academic community. CCRIS consists of an explanatory text of 16 pages introducing the reader to a set of 1500 edge-notched McBee cards. Each card contains a…

  9. The Civil Rights Commission Must Persist

    ERIC Educational Resources Information Center

    Reynolds, Gerald A.

    2007-01-01

    Columnist George Will and others have questioned the continuing need for a federal civil rights commission, because civil rights protections have been on the books since 1964. The chairman of the Commission, Gerald Reynolds, here responds that practitioners of critical legal theory, advocates of the Akaka-Secession bill, some proponents of…

  10. Commission on Preservation and Access Newsletter, 1996.

    ERIC Educational Resources Information Center

    Commission on Preservation and Access Newsletter, 1996

    1996-01-01

    The Commission on Preservation and Access was established to foster and support collaboration among libraries and allied organizations in order to ensure the preservation of the published and documentary record in all formats and to provide enhanced access to scholarly information. The Commission's newsletter keeps preservation and access…

  11. 16 CFR 1101.51 - Commission interpretation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Commission interpretation. 1101.51 Section 1101.51 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT Retraction § 1101.51...

  12. 76 FR 53159 - CFC-50 Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ..., 2011, at the time and location shown below. The Commission shall advise the Director of the U.S. Office... committee composed of Federal employees, private campaign administrators, charitable organizations and... to present material to the Commission at the meeting. The manner and time prescribed for...

  13. Alaska Women's Commission Regional Conferences 1986.

    ERIC Educational Resources Information Center

    Callahan, Christine

    This booklet describes the work of the Alaska Women's Commission, a state agency dedicated to the achievement of equal legal, economic, social, and political status for women in Alaska. Since its inception, the Alaska Women's Commission has provided funding for regional women's conferences in rural parts of the state. The document describes four…

  14. 47 CFR 1.1528 - Commission review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Commission review. 1.1528 Section 1.1528 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Implementation of the Equal Access to Justice Act (EAJA) in Agency Proceedings Procedures for Considering Applications § 1.1528...

  15. Women Appointed to State Boards and Commissions.

    ERIC Educational Resources Information Center

    Rutgers, The State Univ., New Brunswick, NJ. Center for the American Woman and Politics.

    The report analyzed the average proportions of women on 2,134 state boards and commissions in ten areas of state government. Data were collected in 1975 at the request of the Women in Power Committee of the National Commission on the Observance of International Women's Year. The ten functional areas of government were business regulation, economic…

  16. 29 CFR 1603.304 - Commission decision.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... EXEMPT STATE AND LOCAL GOVERNMENT EMPLOYEE COMPLAINTS OF EMPLOYMENT DISCRIMINATION UNDER SECTION 304 OF... consideration by the Commission. (b) When an administrative law judge certifies a matter for interlocutory review under § 1603.213, the Commission may, in its discretion, issue a decision on the matter or send...

  17. 76 FR 63325 - National Indian Gaming Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ...--management fee The NOI asked whether the Commission should consider whether the definition of net revenues.... Management Contracts--Collateral Agreements The NOI asked whether the Commission should consider promulgating a regulation requiring the review and approval of collateral agreements to a management contract. A...

  18. Commission 22: Meteors, Meteorites and Interplanetary Dust

    NASA Astrophysics Data System (ADS)

    Spurný, Pavel; Watanabe, Jun-ichi; Mann, Ingrid; Borovička, Jiří; Baggaley, William J.; Brown, Peter G.; Consolmagno, Guy J.; Jenniskens, Peter M. M.; Pellinen-Wannberg, Asta K.; Porubčan, Vladimír; Williams, Iwan P.; Yano, Hajime

    Commission 22 is part of Division III on Planetary System Sciences of the International Astronomical Union. Members of Commission 22 are professional scientists studying bodies in the Solar System smaller than asteroids and comets, and their interactions with planets. The main subjects of interest are meteors, meteoroids, meteoroid streams, interplanetary dust particles, and also zodiacal cloud, meteor trains, meteorites, tektites, etc.

  19. Appalachian Regional Commission Annual Report, 2001.

    ERIC Educational Resources Information Center

    Appalachian Regional Commission, Washington, DC.

    In fiscal year 2001, the Appalachian Regional Commission invested $63.6 million in 469 economic and human development (nonhighway) projects and $389.6 million in highway projects in Appalachia. The Commission launched a new initiative to promote the development of telecommunications infrastructure, especially in distressed counties. The Commission…

  20. 10 CFR 1.11 - The Commission.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false The Commission. 1.11 Section 1.11 Energy NUCLEAR.... (a) The Nuclear Regulatory Commission, composed of five members, one of whom is designated by the... for licensing and regulating nuclear facilities and materials and for conducting research in support...

  1. 10 CFR 1.11 - The Commission.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false The Commission. 1.11 Section 1.11 Energy NUCLEAR.... (a) The Nuclear Regulatory Commission, composed of five members, one of whom is designated by the... for licensing and regulating nuclear facilities and materials and for conducting research in support...

  2. The Civil Rights Commission Must Persist

    ERIC Educational Resources Information Center

    Reynolds, Gerald A.

    2007-01-01

    Columnist George Will and others have questioned the continuing need for a federal civil rights commission, because civil rights protections have been on the books since 1964. The chairman of the Commission, Gerald Reynolds, here responds that practitioners of critical legal theory, advocates of the Akaka-Secession bill, some proponents of…

  3. 76 FR 24081 - Notice of Commission Determination

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ..., or Rhinestreet shale formations. DATES: April 21, 2011. ADDRESSES: Susquehanna River Basin Commission... the Antes, Burket, Geneseo, Mandata, Middlesex, Needmore, or Rhinestreet shale formations shall be... Marcellus or Utica shale formations that the Commission has already determined to be subject to review...

  4. Faculty Mentoring: What the Boyer Commission Forgot

    ERIC Educational Resources Information Center

    Wasburn, Mara H.

    2005-01-01

    In 1998, a Carnegie Foundation Commission Report criticized America's 123 research universities for failing our educational system by ignoring undergraduate education. Notably absent from the Commission's list of recommendations was mentoring research university faculty as a strategy to improve their teaching. This article discusses strategic …

  5. 33 CFR 209.50 - Mississippi River Commission: Public observation of Commission meetings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Mississippi River Commission... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.50 Mississippi River... of the Mississippi River Commission and to open all meetings of the Mississippi River Commission...

  6. 33 CFR 209.50 - Mississippi River Commission: Public observation of Commission meetings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Mississippi River Commission... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.50 Mississippi River... of the Mississippi River Commission and to open all meetings of the Mississippi River Commission...

  7. 33 CFR 209.50 - Mississippi River Commission: Public observation of Commission meetings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Mississippi River Commission... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.50 Mississippi River... of the Mississippi River Commission and to open all meetings of the Mississippi River Commission...

  8. 33 CFR 209.50 - Mississippi River Commission: Public observation of Commission meetings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Mississippi River Commission... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.50 Mississippi River... of the Mississippi River Commission and to open all meetings of the Mississippi River Commission...

  9. Commission 5: Documentation and Astronomical Data

    NASA Astrophysics Data System (ADS)

    Genova, Françoise; Norris, Raymond P.; Dluzhnevskaya, Olga B.; Bessel, Michael S.; Jenker, H.; Malkov, Oleg Yu.; Murtagh, Fionn; Nakajima, Koichi; Ochsenbein, François; Pence, William D.; Schmitz, Marion; Wielen, Roland; Zhao, Yong Heng

    2007-12-01

    Commission 5 has been very active during the IAU XXVI General Assembly in Prague: the Commission, its Working Groups and its Task Force held business meetings. In addition, Commission 5 sponsored two Special Sessions: Special Session 3 on The Virtual Observatory in Action: New Science, New Technology, and Next Generation Facilities which was held for three days 17 22 August, and Special Session 6 on Astronomical Data Management, which was held on 22 August. Commission 5 also participated in the organisation of Joint Discussion 16 on Nomenclature, Precession and New Models in Fundamental Astronomy, which was held 22-23 August. The General Assembly and Commission 5 web sites provides links to detailed information about all these meetings.

  10. A Practical Guide for Commissioning Existing Buildings

    SciTech Connect

    Haasl, T.; Sharp, T.

    1999-04-01

    Although this guide focuses on the retrocommissioning process and its advantages, all three types of commissioning--retrocommissioning, commissioning, and recommissioning--play an equally important role in ensuring that buildings perform efficiently and provide comfortable, safe, and productive work environments for owners and occupants. For new construction and retrofit projects, commissioning should be incorporated early, during design, and last throughout the length of the project. For buildings that were never commissioned, the retrocommissioning process can yield a wealth of cost-saving opportunities while enhancing a building's environment. Finally, once a building is commissioned or retrocommissioned, incorporating recommissioning into the organization's O and M program (by periodically reapplying the original diagnostic testing and checklist procedures) helps ensure that cost savings and other benefits gained from the original process persist over time.

  11. A Practical Guide for Commissioning Existing Buildings

    SciTech Connect

    Haasl, T.

    1999-05-11

    Although this guide focuses on the retrocommissioning process and its advantages, all three types of commissioning--retrocommissioning, commissioning, and recommissioning--play an equally important role in ensuring that buildings perform efficiently and provide comfortable, safe, and productive work environments for owners and occupants. For new construction and retrofit projects, commissioning should be incorporated early, during design, and last throughout the length of the project. For buildings that were never commissioned, the retrocommissioning process can yield a wealth of cost-saving opportunities while enhancing a building's environment. Finally, once a building is commissioned or retrocommissioned, incorporating recommissioning into the organization's O and M program (by periodically reapplying the original diagnostic testing and checklist procedures) helps ensure that cost savings and other benefits gained from the original process persist over time.

  12. Commissioning a museum and archival storage facility

    SciTech Connect

    Ellis, R.T.

    1996-11-01

    The post-construction heating, ventilating, and air-conditioning (HVAC) system commissioning process undertaken at a new 425,000-ft{sup 2} historical museum and archival storage facility is described. The commissioning agent was not brought into the process until construction was complete, the building was occupied, and the HVAC systems were found to be functioning improperly. The author, who served as the third-party commissioning agent, describes the process of identifying the causes of system problems, performing verification tests, correcting problems, and working to re-create a team approach to problem solving following a year of finger-pointing. The paper concludes with a discussion of how involving a commissioning agent throughout the design and construction process, as recommended in ASHRAE`s Guideline 1, Commissioning of HVAC Systems, instead of just for post-construction troubleshooting, would have benefited all parties involved in the project.

  13. The Integration Role of European Defense Procurement in Achieving a More Competitive and Stronger European Defense Equipment Market

    DTIC Science & Technology

    2015-06-01

    problems for the interpretation and implementation of European law in this market segment ” (Schmitt, 2005, p. 3) and even a defense directive would...Community instruments and pursue the same objective in a different segment of the defense market (European Commission, 2005). In December 2006... segments , but it would cover also non- military security segments . In an ideal situation, it was expected both the supply and demand sides of the market

  14. Dynamic rupture simulations on complex fault zone structures with off-fault plasticity using the ADER-DG method

    NASA Astrophysics Data System (ADS)

    Wollherr, Stephanie; Gabriel, Alice-Agnes; Igel, Heiner

    2015-04-01

    In dynamic rupture models, high stress concentrations at rupture fronts have to to be accommodated by off-fault inelastic processes such as plastic deformation. As presented in (Roten et al., 2014), incorporating plastic yielding can significantly reduce earlier predictions of ground motions in the Los Angeles Basin. Further, an inelastic response of materials surrounding a fault potentially has a strong impact on surface displacement and is therefore a key aspect in understanding the triggering of tsunamis through floor uplifting. We present an implementation of off-fault-plasticity and its verification for the software package SeisSol, an arbitrary high-order derivative discontinuous Galerkin (ADER-DG) method. The software recently reached multi-petaflop/s performance on some of the largest supercomputers worldwide and was a Gordon Bell prize finalist application in 2014 (Heinecke et al., 2014). For the nonelastic calculations we impose a Drucker-Prager yield criterion in shear stress with a viscous regularization following (Andrews, 2005). It permits the smooth relaxation of high stress concentrations induced in the dynamic rupture process. We verify the implementation by comparison to the SCEC/USGS Spontaneous Rupture Code Verification Benchmarks. The results of test problem TPV13 with a 60-degree dipping normal fault show that SeisSol is in good accordance with other codes. Additionally we aim to explore the numerical characteristics of the off-fault plasticity implementation by performing convergence tests for the 2D code. The ADER-DG method is especially suited for complex geometries by using unstructured tetrahedral meshes. Local adaptation of the mesh resolution enables a fine sampling of the cohesive zone on the fault while simultaneously satisfying the dispersion requirements of wave propagation away from the fault. In this context we will investigate the influence of off-fault-plasticity on geometrically complex fault zone structures like subduction

  15. “NEPP” Peritoneal Dialysis Regimen Has Beneficial Effects on Plasma CEL and 3-DG, But Not Pentosidine, CML, and MGO

    PubMed Central

    le Poole, Caatje Y.; van Ittersum, Frans J.; Valentijn, Rob M.; Teerlink, Tom; Lindholm, Bengt; Wee, Piet M. Ter; Schalkwijk, Casper G.

    2012-01-01

    ♦ Background: Standard peritoneal dialysis (PD) solutions contain high levels of glucose and glucose degradation products (GDPs), both contributing to the formation of advanced glycation end products (AGEs). We studied the contribution to plasma GDP and AGE levels of 2 PD regimens that differ in glucose and GDP loads: high load [standard PD (sPD) using 4 glucose–lactate exchanges] and low load [1 amino acid exchange, 1 icodextrin exchange, and 2 glucose–bicarbonate/lactate exchanges (“NEPP”)]. ♦ Methods: In a prospective crossover study (2 periods of 24 weeks), new continuous ambulatory PD patients were randomized to NEPP–sPD (n = 23) or to sPD–NEPP (n = 27). ♦ Results: After the start of PD, absolute increases were observed in plasma levels of 3-deoxyglucosone (3-DG, 220.4 nmol/L, p < 0.0001) and in Nε-(carboxymethyl) lysine (CML) in plasma proteins (0.02 μmol/L CML per 1 mol/L lysine, p < 0.0001). During the first 6 weeks, 3-DG tended to increase more with sPD treatment (p = 0.08), and CML, with NEPP treatment (p = 0.002). In both groups, Nε-(carboxyethyl)lysine (CEL) in plasma proteins declined significantly with the start of PD. Treatment with NEPP resulted in higher levels of methylglyoxal (MGO) and lower levels of 3-DG and CEL. Pentosidine in the albumin fraction tended to increase less during NEPP treatment. ♦ Conclusions: A low glucose and GDP PD regimen (NEPP) resulted in plasma levels of 3-DG and CEL that were lower than those with a glucose-based sPD regimen. Starting PD with NEPP was associated with a steeper increase in CML, and continuing treatment with NEPP resulted in higher MGO levels. PMID:21632443

  16. A Very Bright, Very Hot, and Very Long Flaring Event from the M Dwarf Binary System DG CVn

    NASA Astrophysics Data System (ADS)

    Osten, Rachel A.; Kowalski, Adam; Drake, Stephen A.; Krimm, Hans; Page, Kim; Gazeas, Kosmas; Kennea, Jamie; Oates, Samantha; Page, Mathew; de Miguel, Enrique; Novák, Rudolf; Apeltauer, Tomas; Gehrels, Neil

    2016-12-01

    On 2014 April 23, the Swift satellite responded to a hard X-ray transient detected by its Burst Alert Telescope, which turned out to be a stellar flare from a nearby, young M dwarf binary DG CVn. We utilize observations at X-ray, UV, optical, and radio wavelengths to infer the properties of two large flares. The X-ray spectrum of the primary outburst can be described over the 0.3-100 keV bandpass by either a single very high-temperature plasma or a nonthermal thick-target bremsstrahlung model, and we rule out the nonthermal model based on energetic grounds. The temperatures were the highest seen spectroscopically in a stellar flare, at T X of 290 MK. The first event was followed by a comparably energetic event almost a day later. We constrain the photospheric area involved in each of the two flares to be >1020 cm2, and find evidence from flux ratios in the second event of contributions to the white light flare emission in addition to the usual hot, T ˜ 104 K blackbody emission seen in the impulsive phase of flares. The radiated energy in X-rays and white light reveal these events to be the two most energetic X-ray flares observed from an M dwarf, with X-ray radiated energies in the 0.3-10 keV bandpass of 4 × 1035 and 9 × 1035 erg, and optical flare energies at E V of 2.8 × 1034 and 5.2 × 1034 erg, respectively. The results presented here should be integrated into updated modeling of the astrophysical impact of large stellar flares on close-in exoplanetary atmospheres.

  17. Very Bright, Very Hot and Very Long: Swift Observations of the DG CVn "Superflare" of April 23rd, 2014

    NASA Astrophysics Data System (ADS)

    Drake, Stephen Alan; Osten, Rachel A.; Page, Kim L; Kennea, Jamie A; Oates, Samantha R; Krimm, Hans A; Gehrels, Neil; Page, Mathew J; Kowalski, Adam

    2014-08-01

    On April 23rd this year, one of the 2 stars in the close visual binary dM4e system DG CVn flared to a level bright enough 300 milliCrab in the 15-150 keV band) that it triggered the Swift Burst Alert Telescope. Two minutes later, after Swift had slewed to the direction of this source, the Swift X-ray Telescope (XRT) and the Ultraviolet Optical Telescope (UVOT) commenced observing this flare. These observations continued (intermittently) for about 20 days and yielded a fascinating case history of this colossal event, the decay of which took more than a week in the UV and soft X-ray regions, and included several smaller superimposed secondary flares. The peak 0.3-10 keV luminosity observed by the XRT of 1.9e32 erg/s at the 18 pc distance of this system is 1.5 times the 'normal' combined systemic bolometric luminosity of 1.3e32 erg/s, making this event a super-bolometric flare similar to the 2008 flare of EV Lac (also detected by Swift). The BAT and XRT spectra of this flare in the first 6 minutes indicate that the emission was dominated by very hot (>>10 keV) plasma and/or a non-thermal power-law emission. This flare is arguably the longest, most X-ray luminous and hottest flare ever seen for an M dwarf in the solar neighborhood, and is reminiscent of the 9 days long flare of the RS CVn binary CF Tuc detected by ROSAT. We discuss how these exceptional characteristics may be related to the known properties of this system, specifically to its youth (30 Myr) and rapid rotation (55 km/s).

  18. Molecular characterization of a homolog of the ferric-uptake regulator, Fur, from the marine bacterium Marinobacter algicola DG893.

    PubMed

    Barker, Ryan A; Tisnado, Jerrell; Lambert, Lisa A; Gärdes, Astrid; Carrano, Mary W; Carrano, Paul N; Gillian, Christopher; Carrano, Carl J

    2015-02-01

    Full length recombinant iron regulatory protein, Fur, has been isolated and characterized from the algal-associated marine bacterium Marinobacter algicola DG893. Under nondenaturing conditions the Fur protein behaves on size exclusion chromatography as a dimer while it is monomeric under SDS PAGE conditions. ICP-MS and fluorescence quenching experiments show that Mb-Fur binds a single metal ion (Zn, Mn, or Co) per monomer. Electrophoretic mobility shift assays were used to probe the interaction of Mb-Fur with the purported Fur box in the promoter region upstream of the vibrioferrin biosynthetic operon. Interaction of Mb-Fur with a 100 bp DNA fragment containing the Fur box in the presence of 10 µM Mn, Co or Zn(II) resulted in decreased migration of DNA on a 7.5% polyacrylamide gel. In the absence of the Fur protein or the metal, no interaction is seen. The presence of EDTA in the binding, loading or running buffers also abolished all activity demonstrating the importance of the metal in formation of the promoter-repressor complex. Based on a high degree of similarity between Mb-Fur and its homolog from Pseudomonas aeruginosa (PA) whose X-ray structure is known we developed a structural model for the former which suggested that only one of the several metal binding sites found in other Fur's would be functional. This is consistent with the single metal binding stoichiometry we observed. Since the purported metal binding site was one that has been described as "structural" rather than "functional" in PA and yet the monometallic Mb-Fur retains DNA Fur box binding ability it reopens the question of which site is which, or if different species have adapted the sites for different purposes.

  19. Molecular characterization of a homolog of the ferric-uptake regulator, Fur, from the marine bacterium Marinobacter algicola DG893

    PubMed Central

    Barker, Ryan A.; Tisnado, Jerrell; Lambert, Lisa A.; Gärdes, Astrid; Carrano, Mary W.; Carrano, Paul N.; Gillian, Christopher

    2016-01-01

    Full length recombinant iron regulatory protein, Fur, has been isolated and characterized from the algal-associated marine bacterium Marinobacter algicola DG893. Under nondenaturing conditions the Fur protein behaves on size exclusion chromatography as a dimer while it is monomeric under SDS PAGE conditions. ICP-MS and fluorescence quenching experiments show that Mb-Fur binds a single metal ion (Zn, Mn, or Co) per monomer. Electrophoretic mobility shift assays were used to probe the interaction of Mb-Fur with the purported Fur box in the promoter region upstream of the vibrioferrin biosynthetic operon. Interaction of Mb-Fur with a 100 bp DNA fragment containing the Fur box in the presence of 10 μM Mn, Co or Zn(II) resulted in decreased migration of DNA on a 7.5 % polyacrylamide gel. In the absence of the Fur protein or the metal, no interaction is seen. The presence of EDTA in the binding, loading or running buffers also abolished all activity demonstrating the importance of the metal in formation of the promoter-repressor complex. Based on a high degree of similarity between Mb-Fur and its homolog from Pseudomonas aeruginosa (PA) whose X-ray structure is known we developed a structural model for the former which suggested that only one of the several metal binding sites found in other Fur’s would be functional. This is consistent with the single metal binding stoichiometry we observed. Since the purported metal binding site was one that has been described as “structural” rather than “functional” in PA and yet the monometallic Mb-Fur retains DNA Fur box binding ability it reopens the question of which site is which, or if different species have adapted the sites for different purposes. PMID:25528647

  20. Instrumented home energy rating and commissioning

    SciTech Connect

    Wray, Craig P.; Walker, Iain S.; Sherman, Max H.

    2003-05-01

    Currently, houses do not perform optimally or even as many codes and forecasts predict, largely because they are field assembled and there is no consistent process to identify deficiencies or to correct them. Solving this problem requires field performance evaluations using appropriate and agreed upon procedures in the form of a new process called residential commissioning. The purpose of this project is to develop and document these procedures and to demonstrate the value that applying them could provide in both new and existing California houses. This project has four specific objectives: to develop metrics and diagnostics for assessing house performance, to provide information on the potential benefits of commissioning using a whole-house approach, to develop programmatic guidelines for commissioning, and to conduct outreach efforts to transfer project results to industry stakeholders. The primary outcomes from this project are the development of residential commissioning guidelines and the analytical confirmation that there are significant potential benefits associated with commissioning California houses, particularly existing ones. In addition, we have made substantial advances in understanding the accuracy and usability of diagnostics for commissioning houses. In some cases, we have been able to work with equipment manufacturers to improve these aspects of their diagnostic tools. These outcomes provide a solid foundation on which to build a residential commissioning program in California. We expect that a concerted effort will be necessary to integrate such a program with existing building industry efforts and to demonstrate its use in the field.

  1. Electroluminescent TCC, C3dg and fB/Bb epitope assays for profiling complement cascade activation in vitro using an activated complement serum calibration standard.

    PubMed

    van Vuuren, B Jansen; Bergseth, G; Mollnes, T E; Shaw, A M

    2014-01-15

    Electroluminescent assays for epitopes on the complement components C3dg, terminal complement complex (TCC) and factor B/Bb (fB/Bb) have been developed with capture and detection antibodies to produce detection limits C3dg=91±9ng/mL, TCC=3±0.1ng/mL and fB=55.7±0.1ng/mL. The assay performance was assessed against a series of zymosan and heat aggregated IgG (HAIgG) in vitro activations of complement using a calibrated activated complement serum (ACS) as calibration standard. The ACS standard was stable within 20% accuracy over a 6-month period with freeze-thaw cycles as required. Differential activation of the complement cascade was observed for TCC showing a pseudo-first order formation half-life of 3.5h after activation with zymosan. The C3dg activation fragment indicates a 10% total activation for both activation agents. The kinetic-epitope analysis for fB indicates that the capture epitope is on the fB/Bb protein fragment which can then become covered by the formation of C3bBb or C3bBbP complexes during the time course of the cascade.

  2. High zinc ion supplementation of more than 30 μM can increase monoclonal antibody production in recombinant Chinese hamster ovary DG44 cell culture.

    PubMed

    Kim, Bong Gyun; Park, Hong Woo

    2016-03-01

    Effects of high ZnSO4·7H2O supplementation on cell growth and monoclonal antibody (mAb) production in chemically defined suspension cultures of recombinant Chinese hamster ovary (rCHO) DG44 cells were examined. The supplementation of ZnSO4·7H2O up to 120 μM gradually increased specific mAb production rate of rCHO DG44 cells in the early growth phase (0-4 days of culture). The ZnSO4·7H2O concentration for enhancing mAb production without any cytotoxic effects on cell growth was 30-60 μM. In addition of 60 μM ZnSO4·7H2O to in-house protein-free medium and in-house chemically defined medium, mAb production was increased 2.0-fold and 6.5-fold, respectively. Moreover, addition of ZnSO4·7H2O to three kinds of commercial chemically defined media yielded a greater than 1.2-fold enhancement of mAb production. These data indicate that simple supplementation of a relatively high zinc ion concentration to cell culture media without significant changes of rCHO DG44 cell culture process can be useful for achieving high production of mAb.

  3. Nuclear Regulatory Commission: more aggressive leadership needed

    SciTech Connect

    Staats, E.B.

    1980-01-15

    The Energy Reorganization Act of 1974 which established the Nuclear Regulatory Commission required GAO to evaluate the Commission's performance by January 18, 1980. This report responds to that requirement. GAO concluded that, although improvements have been made, the Commission's nuclear regulatory performance can be characterized best as slow, indecisive, cautious - in a word, complacent. This has largely resulted from a lack of aggressive leadership as evidenced by the Commissioners' failure to establish regulatory goals, control policymaking, and most importantly, clearly define their roles in nuclear regulation.

  4. Division G Commission 42: Close Binary Stars

    NASA Astrophysics Data System (ADS)

    Richards, Mercedes T.; Pribulla, Theodor; Ribas, Ignasi; Bradstreet, David H.; Dreschsel, Horst; Maceroni, Carla; Mikolajewska, Joanna; Munari, Ulisse; Prsa, Andrej; Scharfe, Colin; Southworth, John; Trimble, Virginia

    2016-04-01

    Commission 42 began life as Photometric Double Stars in 1948 at the 7th General Assembly in Zurich, under the presidency of Zdenek Kopal. As early as 1961, then General Secretary Lukas Plaut recommended a merger between C42 and C26, Double Stars, one of the original 32 commissions going back to 1919-22 (first president Aitken, assistant director at Lick). C42 became Close Binary Stars in 1970, at the 14th GA in Brighton (the first one I attended). Table 1 shows the presidents of C42, and vice presidents, from when the office started, through the history of the Commission.

  5. Presidential commission investigating Challenger accident at KSC

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Views of the Presidential commission investigating the Challenger accident at Kennedy Space Center (KSC). Photos include NASA Astronaut Robert Crippen pointing out Discovery tile work in the Vehicle Assembly Building (28888); KSC Director Richard Smith points out a portion of a solid rocket booster segment to Astronaut Sally Ride and to the chairman of the Presidential Commission, William P. Rogers (28889); Rogers and other members of the Pressidential commission examines the propellent contained in a solid rocket booster segment stored at one of the KSC ordinance facilities (28890).

  6. Presidential commission investigating Challenger accident at KSC

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Views of the Presidential commission investigating the Challenger accident at Kennedy Space Center (KSC). Photos include NASA Astronaut Robert Crippen pointing out Discovery tile work in the Vehicle Assembly Building (28888); KSC Director Richard Smith points out a portion of a solid rocket booster segment to Astronaut Sally Ride and to the chairman of the Presidential Commission, William P. Rogers (28889); Rogers and other members of the Pressidential commission examines the propellent contained in a solid rocket booster segment stored at one of the KSC ordinance facilities (28890).

  7. Joint Commission suspends 'auto' adverse decision.

    PubMed

    2010-08-01

    The Joint Commission's revision of its policy on root cause analysis puts greater attention of something that, quite frankly, some ED managers might not have been aware of. The ED manager plays an important role when events occur in the department, such as: knowing who the main Joint Commission contact is in the hospital, and making them aware of a potential adverse or sentinel event that has occurred; participating in the root cause analysis to identify what ED processes might need improvement; making sure the remedial activities recommended can be measured, so The Joint Commission can see an active attempt is being made to improve.

  8. Status of European appliance standards

    SciTech Connect

    Turiel, I.; Lebot, B.

    1992-05-01

    The European Community (EC) recently commissioned a study of the impact of potential appliance standards on electricity consumption in the twelve EC nations. This study looks at refrigerators, freezers, dishwashers, clothes washers, and clothes dryers. The impact of minimum efficiency standards on electricity use over the time period from 1995--2010 is estimated. The results of this study were presented to the EC in September of 1991. Revisions were made to the draft report and final copies sent to all interested parties. The member nations of the EC will soon consider whether they wish to implement uniform energy efficiency standards that would take effect in 1995. The results of the study described above will be presented and the political considerations will be discussed. In addition, data describing the appliance market in Europe will be presented.

  9. NUMERIC: Statistics for the Digitisation of European Cultural Heritage

    ERIC Educational Resources Information Center

    Poll, Roswitha

    2010-01-01

    Purpose: The purpose of this paper is to present results of NUMERIC, a project of the European Commission that started out to define measures and methods for assessing the current state of digitisation in Europe's cultural institutions (archives, libraries and museums). The central task of the NUMERIC project was to develop a framework for the…

  10. NUMERIC: Statistics for the Digitisation of European Cultural Heritage

    ERIC Educational Resources Information Center

    Poll, Roswitha

    2010-01-01

    Purpose: The purpose of this paper is to present results of NUMERIC, a project of the European Commission that started out to define measures and methods for assessing the current state of digitisation in Europe's cultural institutions (archives, libraries and museums). The central task of the NUMERIC project was to develop a framework for the…

  11. Inclusive Education in Progress: Policy Evolution in Four European Countries

    ERIC Educational Resources Information Center

    Smyth, Fiona; Shevlin, Michael; Buchner, Tobias; Biewer, Gottfried; Flynn, Paula; Latimier, Camille; Šiška, Jan; Toboso-Martín, Mario; Rodríguez Díaz, Susana; Ferreira, Miguel A. V.

    2014-01-01

    This paper seeks to compare the evolution of inclusive education policy in the four countries of an EU-funded research project (QualiTYDES) operating under the shared policy environment of the UN, EU and European Commission. A shared policy cannot of course be assumed to result in common legislative or provisional outcomes at national level. The…

  12. Developing Telecommunications within European Teacher Education: Progress, Plans, and Policy.

    ERIC Educational Resources Information Center

    Davis, Niki

    Teacher training is high on the priorities of the European Commission. One action has been to fund three Telematics projects that focus on telematics and teacher training within the Telematics Application Program. This paper is part of the work of the T3 (Telematics for Teacher Training) project which is coordinated from the University of Exeter.…

  13. The ECO European Project: A New MOOC Dimension Based on an Intercreativity Environment

    ERIC Educational Resources Information Center

    Acedo, Sara Osuna; Cano, Lucía Camarero

    2016-01-01

    The ECO European Project funded by the European Commission is dedicated to bringing MOOCs to a new dimension by taking advantage of the new possibilities offered by the Social Web (O'Reilly, 2005). This paper focuses on the intercreative aspects of MOOCs. It takes a look at the characteristics of the new ECO MOOCs to see if they are designed and…

  14. European Master's Program in Gerontology (EuMaG): Goals, Curriculum, and Students

    ERIC Educational Resources Information Center

    Aartsen, Marja

    2011-01-01

    The European Master's Program in Gerontology (EuMaG) started in September 2003 with support from the European Commission. The EuMaG is a modular, 2-year, part-time international training program about the aging process and its societal implications. The multidisciplinary curriculum comprises four domains of gerontology (i.e., social gerontology,…

  15. Conducting Research into European Union Education and Training Policy: Some Theoretical and Methodological Considerations.

    ERIC Educational Resources Information Center

    Phillips, David; Economou, Anastasia

    1999-01-01

    Discusses PRESTIGE, the project funded by the European Commission within its Training and Mobility Researchers program, describing the research design of the Oxford part of the project. Describes a comparative study of the implementation of the 'European Dimension' in education in England, Scotland, and Wales. Considers the methodological and…

  16. Proposal for National Targets in the Framework of the European Reduction Goal for Early School Leaving

    ERIC Educational Resources Information Center

    Lastra-Bravo, Xavier B.; Tolón-Becerra, Alfredo; Salinas-Andújar, José A.

    2013-01-01

    According to the European Commission's "Europe 2020" strategy, the early school leaving (ESL) rate in European Union (EU) Member States must be reduced to a maximum of 10 per cent by 2020. This paper proposes a nonlinear distribution method based on dynamic targets for reducing the percentage of early school leavers. The aim of this…

  17. European Master's Program in Gerontology (EuMaG): Goals, Curriculum, and Students

    ERIC Educational Resources Information Center

    Aartsen, Marja

    2011-01-01

    The European Master's Program in Gerontology (EuMaG) started in September 2003 with support from the European Commission. The EuMaG is a modular, 2-year, part-time international training program about the aging process and its societal implications. The multidisciplinary curriculum comprises four domains of gerontology (i.e., social gerontology,…

  18. Proposal for National Targets in the Framework of the European Reduction Goal for Early School Leaving

    ERIC Educational Resources Information Center

    Lastra-Bravo, Xavier B.; Tolón-Becerra, Alfredo; Salinas-Andújar, José A.

    2013-01-01

    According to the European Commission's "Europe 2020" strategy, the early school leaving (ESL) rate in European Union (EU) Member States must be reduced to a maximum of 10 per cent by 2020. This paper proposes a nonlinear distribution method based on dynamic targets for reducing the percentage of early school leavers. The aim of this…

  19. Flexibility as a Key Construct in European Training: Experiences from the TeleScopia Project.

    ERIC Educational Resources Information Center

    Collis, Betty; And Others

    1997-01-01

    Discusses the paradigm shift toward more open and flexible learning and training options through telematics, based on experiences of the TeleScopia (Trans-European Learning System for Crossborder Open and Interactive Applications) Project, sponsored by the Commission of the European Community. (LRW)

  20. The Practice of Media Education: International Research on Six European Countries

    ERIC Educational Resources Information Center

    Parola, Alberto; Ranieri, Maria

    2011-01-01

    This paper presents and discusses the results of OnAir, a European project on Media Education funded by the European Commission. This two-year project aimed at collecting, documenting, and developing media education practices across Europe, especially in Belgium, Bulgaria, Italy, Lithuania, Poland, and Romania. In particular, the paper focuses on…