Molecular Pathogenesis of NASH

PubMed Central

Caligiuri, Alessandra; Gentilini, Alessandra; Marra, Fabio

2016-01-01

Nonalcoholic steatohepatitis (NASH) is the main cause of chronic liver disease in the Western world and a major health problem, owing to its close association with obesity, diabetes, and the metabolic syndrome. NASH progression results from numerous events originating within the liver, as well as from signals derived from the adipose tissue and the gastrointestinal tract. In a fraction of NASH patients, disease may progress, eventually leading to advanced fibrosis, cirrhosis and hepatocellular carcinoma. Understanding the mechanisms leading to NASH and its evolution to cirrhosis is critical to identifying effective approaches for the treatment of this condition. In this review, we focus on some of the most recent data reported on the pathogenesis of NASH and its fibrogenic progression, highlighting potential targets for treatment or identification of biomarkers of disease progression. PMID:27657051

Magnetospheric Convection Electric Field Dynamics and Stormtime Particle Energization: Case Study of the Magnetic Storm of May 4,1998

NASA Technical Reports Server (NTRS)

Khazanov, George V.; Liemohn, Michael W.; Newman, Tim S.; Fok, Mei-Ching; Ridley, Aaron

2003-01-01

It is shown that narrow channels of high electric field are an effective mechanism for injecting plasma into the inner magnetosphere. Analytical expressions for the electric field cannot produce these channels of intense plasma flow, and thus result in less entry and energization of the plasma sheet into near-Earth space. For the ions, omission of these channels leads to an underprediction of the strength of the stormtime ring current and therefore an underestimation of the geoeffectiveness of the storm event. For the electrons, omission of these channels leads to the inability to create a seed population of 10-100 keV electrons deep in the inner magnetosphere. These electrons can eventually be accelerated into MeV radiation belt particles.

Impact of Atmospheric Blocking on South America in Austral Summer

NASA Astrophysics Data System (ADS)

Rodrigues, Regina; Woollings, Tim

2017-04-01

In this study, we investigate atmospheric blocking over east South America in austral summer for the period of 1979-2014. Our results show that blocking over this area is a consequence of propagating Rossby waves that grow to large amplitudes and eventually break anticyclonically over subtropical South America (SSA). The SSA blocking can prevent the establishment of the South Atlantic Convergence Zone (SACZ). As such, years with more blocking days coincide with years with fewer SACZ days and reduced precipitation. Convection mainly over the Indian Ocean associated with Madden-Julian Oscillation (MJO) phases 1 and 2 can trigger the wave train that leads to SSA blocking whereas convection over the western/central Pacific associated with phases 6 and 7 is more likely to lead to SACZ events. We find that MJO is a key source of long-term variability in SSA blocking frequency. The wave packets associated with SSA blocking and SACZ episodes differ not only in their origin but also in their phase and refraction pattern. The tropopause-based methodology used here is proven to reliably identify events that lead to extremes of surface temperature and precipitation over SSA. Up to 80% of warm surface air temperature extremes occur simultaneously with SSA blocking events. They are also responsible for the warming of western South Atlantic. The frequency of SSA blocking days is highly anti-correlated with the rainfall over southeast Brazil. The worst droughts in this area, during the summers of 1984, 2001 and 2014, are linked to record high numbers of SSA blocking days. The persistence of these events is also important in generating the extreme impacts.

Discovering the route from inflammation to pancreatic cancer

PubMed Central

MOMI, N.; KAUR, S.; KRISHN, S. R.; BATRA, S. K.

2013-01-01

Pancreatic cancer (PC) remains a complex malignancy with the worst prognosis, lack of early diagnostic symptoms and resistance to conventional chemo- and radiotherapies. A better understanding of the etiology and early developmental events of PC requires profound attention. The evolution of fully blown PC from initial pancreatic injury is a multi-factorial phenomenon with a series of sequential events. The initial acute infection or tissue damage triggers inflammation that, in conjunction with innate immunity, establishes a state of homeostasis to limit harm to the body. Recurrent pancreatic injuries due to genetic susceptibility, smoking, unhealthy diet, and alcohol abuse induces a pro-inflammatory milieu, consisting of various types of immune cells, cytokines, chemokines, growth factors and restructured extracellular matrix, leading to prolonged inflammatory/chronic conditions. Cells having sustained DNA damage and/or mutagenic assault take advantage of this prolonged inflammatory response and aid in the initiation and development of neoplastic/fibrotic events. Eventually, many tumor-stromal interactions result in a chaotic environment accompanied by a loss of immune surveillance and repair response, thereby leading to PC. A better understanding of the inflammatory markers defining this “injury-inflammation-cancer” pathway would help to identify novel molecular targets for early screening and therapeutic intervention for this lethal malignancy. PMID:23207606

Emerging Role of Ubiquitination in Antiviral RIG-I Signaling

PubMed Central

Maelfait, Jonathan

2012-01-01

Summary: Detection of viruses by the innate immune system involves the action of specialized pattern recognition receptors. Intracellular RIG-I receptors sense the presence of viral nucleic acids in infected cells and trigger signaling pathways that lead to the production of proinflammatory and antiviral proteins. Over the past few years, posttranslational modification of RIG-I and downstream signaling proteins by different types of ubiquitination has been found to be a key event in the regulation of RIG-I-induced NF-κB and interferon regulatory factor 3 (IRF3) activation. Multiple ubiquitin ligases, deubiquitinases, and ubiquitin binding scaffold proteins contribute to both positive and negative regulation of the RIG-I-induced antiviral immune response. A better understanding of the function and activity of these proteins might eventually lead to the development of novel therapeutic approaches for management of viral diseases. PMID:22390971

Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens.

PubMed

Luan, Xiaojie; Belev, George; Tam, Julian S; Jagadeeshan, Santosh; Hassan, Noman; Gioino, Paula; Grishchenko, Nikolay; Huang, Yanyun; Carmalt, James L; Duke, Tanya; Jones, Teela; Monson, Bev; Burmester, Monique; Simovich, Tomer; Yilmaz, Orhan; Campanucci, Veronica A; Machen, Terry E; Chapman, L Dean; Ianowski, Juan P

2017-10-05

Cystic fibrosis is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) channel, which can result in chronic lung disease. The sequence of events leading to lung disease is not fully understood but recent data show that the critical pathogenic event is the loss of the ability to clear bacteria due to abnormal airway surface liquid secretion (ASL). However, whether the inhalation of bacteria triggers ASL secretion and whether this is abnormal in cystic fibrosis has never been tested. Here we show, using a novel synchrotron-based in vivo imaging technique, that wild-type pigs display both a basal and a Toll-like receptor-mediated ASL secretory response to the inhalation of cystic fibrosis relevant bacteria. Both mechanisms fail in CFTR -/- swine, suggesting that cystic fibrosis airways do not respond to inhaled pathogens, thus favoring infection and inflammation that may eventually lead to tissue remodeling and respiratory disease.Cystic fibrosis is caused by mutations in the CFTR chloride channel, leading to reduced airway surface liquid secretion. Here the authors show that exposure to bacteria triggers secretion in wild-type but not in pig models of cystic fibrosis, suggesting an impaired response to pathogens contributes to infection.

Neural Indices of Semantic Processing in Early Childhood Distinguish Eventual Stuttering Persistence and Recovery

ERIC Educational Resources Information Center

Kreidler, Kathryn; Wray, Amanda Hampton; Usler, Evan; Weber, Christine

2017-01-01

Purpose: Maturation of neural processes for language may lag in some children who stutter (CWS), and event-related potentials (ERPs) distinguish CWS who have recovered from those who have persisted. The current study explores whether ERPs indexing semantic processing may distinguish children who will eventually persist in stuttering…

The roles of impact and inertia in the failure of a shoelace knot

NASA Astrophysics Data System (ADS)

Daily-Diamond, Christopher A.; Gregg, Christine E.; O'Reilly, Oliver M.

2017-04-01

The accidental untying of a shoelace while walking often occurs without warning. In this paper, we discuss the series of events that lead to a shoelace knot becoming untied. First, the repeated impact of the shoe on the floor during walking serves to loosen the knot. Then, the whipping motions of the free ends of the laces caused by the leg swing produce slipping of the laces. This leads to eventual runaway untangling of the knot. As demonstrated using slow-motion video footage and a series of experiments, the failure of the knot happens in a matter of seconds, often without warning, and is catastrophic. The controlled experiments showed that increasing inertial effects of the swinging laces leads to increased rate of knot untying, that the directions of the impact and swing influence the rate of failure, and that the knot structure has a profound influence on a knot's tendency to untie under cyclic impact loading.

DNA reactivity as a mode of action and its relevance to cancer risk assessment.

PubMed

Preston, R Julian

2013-02-01

The ability of a chemical to induce mutations has long been a driver in the cancer risk assessment process. The default strategy has been that mutagenic chemicals demonstrate linear cancer dose responses, especially at low exposure levels. In the absence of additional confounding information, this is a reasonable approach, because risk assessment is appropriately considered as being protective of human health. The concept of mode of action has allowed for an opportunity to move off this default position; mutagenicity is now not considered as the driver but rather the mode of action is. In a more precise way, it is the set of key events that define a mode of action that is fundamental in defining the shape of a cancer dose response. A key event is an informative bioindicator of the cancer response and as such should be predictive of the tumor response, at least in a qualitative way. A clear example of the use of key events in cancer risk assessment is for DNA reactive chemicals. A series of such key events is initiated by the production of DNA damage in target cells from direct interaction of the chemical with DNA leading to the production of mutations by misreplication that results in enhanced cell replication. This enhanced cell replication eventually leads to the development of preneoplastic cells and ultimately overt neoplasms. The response of each of these key events to dose of the chemical can inform the cancer dose-response curve shape. Thus, the dose-response curve for any DNA-reactive chemical can be predicted from knowledge of its mode of action and the behavior of the induced key events.

Negative Life Events and Antenatal Depression among Pregnant Women in Rural China: The Role of Negative Automatic Thoughts.

PubMed

Wang, Yang; Wang, Xiaohua; Liu, Fangnan; Jiang, Xiaoning; Xiao, Yun; Dong, Xuehan; Kong, Xianglei; Yang, Xuemei; Tian, Donghua; Qu, Zhiyong

2016-01-01

Few studies have looked at the relationship between psychological and the mental health status of pregnant women in rural China. The current study aims to explore the potential mediating effect of negative automatic thoughts between negative life events and antenatal depression. Data were collected in June 2012 and October 2012. 495 rural pregnant women were interviewed. Depressive symptoms were measured by the Edinburgh postnatal depression scale, stresses of pregnancy were measured by the pregnancy pressure scale, negative automatic thoughts were measured by the automatic thoughts questionnaire, and negative life events were measured by the life events scale for pregnant women. We used logistic regression and path analysis to test the mediating effect. The prevalence of antenatal depression was 13.7%. In the logistic regression, the only socio-demographic and health behavior factor significantly related to antenatal depression was sleep quality. Negative life events were not associated with depression in the fully adjusted model. Path analysis showed that the eventual direct and general effects of negative automatic thoughts were 0.39 and 0.51, which were larger than the effects of negative life events. This study suggested that there was a potentially significant mediating effect of negative automatic thoughts. Pregnant women who had lower scores of negative automatic thoughts were more likely to suffer less from negative life events which might lead to antenatal depression.

Single-Trial Normalization for Event-Related Spectral Decomposition Reduces Sensitivity to Noisy Trials

PubMed Central

Grandchamp, Romain; Delorme, Arnaud

2011-01-01

In electroencephalography, the classical event-related potential model often proves to be a limited method to study complex brain dynamics. For this reason, spectral techniques adapted from signal processing such as event-related spectral perturbation (ERSP) – and its variant event-related synchronization and event-related desynchronization – have been used over the past 20 years. They represent average spectral changes in response to a stimulus. These spectral methods do not have strong consensus for comparing pre- and post-stimulus activity. When computing ERSP, pre-stimulus baseline removal is usually performed after averaging the spectral estimate of multiple trials. Correcting the baseline of each single-trial prior to averaging spectral estimates is an alternative baseline correction method. However, we show that this method leads to positively skewed post-stimulus ERSP values. We eventually present new single-trial-based ERSP baseline correction methods that perform trial normalization or centering prior to applying classical baseline correction methods. We show that single-trial correction methods minimize the contribution of artifactual data trials with high-amplitude spectral estimates and are robust to outliers when performing statistical inference testing. We then characterize these methods in terms of their time–frequency responses and behavior compared to classical ERSP methods. PMID:21994498

KNOWING CHEMISTRY CAN HELP GET THE LEAD OUT

EPA Science Inventory

Lead in tap water comes from the materials used in plumbing such as from leaded solder, lead pipe, and lead-containing brass found in fittings and faucets. Fortunately, the surface of brass eventually becomes passivated when in contact with most waters. Oxidants in water (usually...

Symbiotic theory of the origin of eukaryotic organelles; criteria for proof.

PubMed

Margulis, L

1975-01-01

The purpose of a scientific theory is to unite apparently disparate observations into a coherent set of generalizations with predictive power. Historical theories, which necessarily treat complex irreversible events, can never be directly tested. However they certainly can lead to predictions. The 'extreme' version of the serial endosymbiotic theory argues that three classes of eukaryotic organelles had free-living ancestors: mitochondria, basal bodies/flagella/cilia [(9 + 2) homologues] and photosynthetic plastids. Many lines of evidence support this theory and can be interpreted in relation to one another on the basis of this theory. Even if this theory should eventually be proved wrong it has the real advantage of generating a large number of unique experimentally verifiable hypotheses.

TNF-induced necroptosis requires the plasma membrane localization of the MLKL protein | Center for Cancer Research

Cancer.gov

The cell signaling protein tumor necrosis factor (TNF), produced by white blood cells, promotes inflammation and immunity processes such as fever and is involved in tumorigenesis and apoptosis (programmed cell death). However, dysregulation of TNF can also lead to another form of programmed cell death called necroptosis, which is characterized by a rise in intracellular Ca2+, generation of reactive oxygen species (ROS), intracellular acidity, depletion of ATP, and, eventually, plasma membrane rupture. TNF-induced necroptosis has been associated with a wide variety of diseases including neurodegenerative diseases, major depression, rheumatoid arthritis, and cancer. Whereas the signaling mechanisms underlying TNF-induced apoptosis have largely been determined, the events precipitating in TNF-initiated necroptosis are still unknown.

Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: Therapeutic implications.

PubMed

Olloquequi, Jordi; Cornejo-Córdova, Elizabeth; Verdaguer, Ester; Soriano, Francesc X; Binvignat, Octavio; Auladell, Carme; Camins, Antoni

2018-03-01

Neurological and psychiatric disorders are leading contributors to the global disease burden, having a serious impact on the quality of life of both patients and their relatives. Although the molecular events underlying these heterogeneous diseases remain poorly understood, some studies have raised the idea of common mechanisms involved. In excitotoxicity, there is an excessive activation of glutamate receptors by excitatory amino acids, leading to neuronal damage. Thus, the excessive release of glutamate can lead to a dysregulation of Ca 2+ homeostasis, triggering the production of free radicals and oxidative stress, mitochondrial dysfunction and eventually cell death. Although there is a consensus in considering excitotoxicity as a hallmark in most neurodegenerative diseases, increasing evidence points to the relevant role of this pathological mechanism in other illnesses affecting the central nervous system. Consequently, antagonists of glutamate receptors are used in current treatments or in clinical trials in both neurological and psychiatric disorders. However, drugs modulating other aspects of the excitotoxic mechanism could be more beneficial. This review discusses how excitotoxicity is involved in the pathogenesis of different neurological and psychiatric disorders and the promising strategies targeting the excitotoxic insult.

[The cognitive-behavioral aspects of the personality of politicians].

PubMed

Resch, Mária; Bella, Tamás

2010-01-17

At the research of the personality of politicians, the task is not psychopathology and thereby the diagnose of a certain illness, but the identification of those features, characteristic marks and the examination of those cognitive functions, attitudes that might affect the ability to lead, might influence the managerial and negotiating style as well as the decisions made during an eventual crisis. Basically, there are two approaches considering the role of personality in politics. The first one regards political events as a projection of the personality of the leading politician; the other one denies entirely the significance of the personality. With reference to the first school, the aim of the present essay is, from among the examinations of the personality of the politician by indirect and direct methods, the determination of the cognitive and behavioral marks connected to the last method. Among the indirect examinations are the analysis of speeches and interviews (psycholinguistics), the reflection of the metacommunicative marks and the psychological elaboration of biographical data (psychobiography). The character of the leading politician is important with respect to image building, campaign work and party competition, "survival".

Gain-of-function somatic mutations contribute to inflammation and blood vessel damage that lead to Alzheimer dementia: a hypothesis.

PubMed

Marchesi, Vincent T

2016-02-01

Amyloid deposits are a characteristic feature of advanced Alzheimer dementia (AD), but whether they initiate the disease or are a consequence of it remains an unsettled question. To explore an alternative pathogenic mechanism, I propose that the triggering events that begin the pathogenic cascade are not amyloid deposits but damaged blood vessels caused by inflammatory reactions that lead to ischemia, amyloid accumulation, axonal degeneration, synaptic loss, and eventually irreversible neuronal cell death. Inflammation and blood vessel damage are well recognized complications of AD, but what causes them and why the cerebral microvasculature is affected have never been adequately addressed. Because heritable autosomal dominant mutations of NLRP3, APP, TREX1, NOTCH3, and Col4A1 are known to provoke inflammatory reactions and damage the brain in a wide variety of diseases, I propose that one or more low abundant, gain-of-function somatic mutations of the same 5 gene families damage the microvasculature of the brain that leads to dementia. This implies that the pathogenic triggers that lead to AD are derived not from external invaders or amyloid but from oxidative damage of our own genes. © FASEB.

Analysis of strong scintillation events by using GPS data at low latitudes

NASA Astrophysics Data System (ADS)

Forte, Biagio; Jakowski, Norbert; Wilken, Volker

2010-05-01

Drifting structures charaterised by inhomogeneities in the spatial electron density distribution at ionospheric heights originate scintillation of radio waves propagating through. The fractional electron density fluctuations and the corresponding scintillation levels may reach extreme values at low latitudes during high solar activity. Strong scintillation events have disruptive effects on a number of technological applications. In particular, operations and services based on GPS signals and receivers may experience severe disruption due to a significant degradation of the signal-to-noise ratio, eventually leading to signal loss of lock. Experimental scintillation data collected in the Asian sector at low latitudes by means of a GPS dual frequency receiver under moderate solar activity (2006) have been analysed. The GPS receiver is particularly modified in firmware in order to record power estimates on the C/A code as well as on the carriers L1 and L2. Strong scintillation activity is recorded in the post-sunset period (saturating S4 and SI as high as 20 dB). An overview of these events is presented, by taking into account scintillation impact on the signal intensity, phase, and dynamics. In particular, the interpretation of these events based on a refined scattering theory is provided with possible consequences for standard scintillation models.

Reliability Design for Neutron Induced Single-Event Burnout of IGBT

NASA Astrophysics Data System (ADS)

Shoji, Tomoyuki; Nishida, Shuichi; Ohnishi, Toyokazu; Fujikawa, Touma; Nose, Noboru; Hamada, Kimimori; Ishiko, Masayasu

Single-event burnout (SEB) caused by cosmic ray neutrons leads to catastrophic failures in insulated gate bipolar transistors (IGBTs). It was found experimentally that the incident neutron induced SEB failure rate increases as a function of the applied collector voltage. Moreover, the failure rate increased sharply with an increase in the applied collector voltage when the voltage exceeded a certain threshold value (SEB cutoff voltage). In this paper, transient device simulation results indicate that impact ionization at the n-drift/n+ buffer boundary is a crucially important factor in the turning-on of the parasitic pnp transistor, and eventually latch-up of the parasitic thyristor causes SEB. In addition, the device parameter dependency of the SEB cutoff voltage was analytically derived from the latch-up condition of the parasitic thyristor. As a result, it was confirmed that reducing the current gain of the parasitic transistor, such as by increasing the n-drift region thickness d was effective in increasing the SEB cutoff voltage. Furthermore, `white' neutron-irradiation experiments demonstrated that suppressing the inherent parasitic thyristor action leads to an improvement of the SEB cutoff voltage. It was confirmed that current gain optimization of the parasitic transistor is a crucial factor for establishing highly reliable design against chance failures.

Building a Database for a Quantitative Model

NASA Technical Reports Server (NTRS)

Kahn, C. Joseph; Kleinhammer, Roger

2014-01-01

A database can greatly benefit a quantitative analysis. The defining characteristic of a quantitative risk, or reliability, model is the use of failure estimate data. Models can easily contain a thousand Basic Events, relying on hundreds of individual data sources. Obviously, entering so much data by hand will eventually lead to errors. Not so obviously entering data this way does not aid linking the Basic Events to the data sources. The best way to organize large amounts of data on a computer is with a database. But a model does not require a large, enterprise-level database with dedicated developers and administrators. A database built in Excel can be quite sufficient. A simple spreadsheet database can link every Basic Event to the individual data source selected for them. This database can also contain the manipulations appropriate for how the data is used in the model. These manipulations include stressing factors based on use and maintenance cycles, dormancy, unique failure modes, the modeling of multiple items as a single "Super component" Basic Event, and Bayesian Updating based on flight and testing experience. A simple, unique metadata field in both the model and database provides a link from any Basic Event in the model to its data source and all relevant calculations. The credibility for the entire model often rests on the credibility and traceability of the data.

Minimum datasets to establish a CAR-mediated mode of action for rodent liver tumors.

PubMed

Peffer, Richard C; LeBaron, Matthew J; Battalora, Michael; Bomann, Werner H; Werner, Christoph; Aggarwal, Manoj; Rowe, Rocky R; Tinwell, Helen

2018-04-16

Methods for investigating the Mode of Action (MoA) for rodent liver tumors via constitutive androstane receptor (CAR) activation are outlined here, based on current scientific knowledge about CAR and feedback from regulatory agencies globally. The key events (i.e., CAR activation, altered gene expression, cell proliferation, altered foci and increased adenomas/carcinomas) can be demonstrated by measuring a combination of key events and associative events that are markers for the key events. For crop protection products, a primary dataset typically should include a short-term study in the species/strain that showed the tumor response at dose levels that bracket the tumorigenic and non-tumorigenic dose levels. The dataset may vary depending on the species and the test compound. As examples, Case Studies with nitrapyrin (in mice) and metofluthrin (in rats) are described. Based on qualitative differences between the species, the key events leading to tumors in mice or rats by this MoA are not operative in humans. In the future, newer approaches such as a CAR biomarker signature approach and/or in vitro CAR3 reporter assays for mouse, rat and human CAR may eventually be used to demonstrate a CAR MoA is operative, without the need for extensive additional studies in laboratory animals. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

High fat programming of beta cell compensation, exhaustion, death and dysfunction.

PubMed

Cerf, Marlon E

2015-03-01

Programming refers to events during critical developmental windows that shape progeny health outcomes. Fetal programming refers to the effects of intrauterine (in utero) events. Lactational programming refers to the effects of events during suckling (weaning). Developmental programming refers to the effects of events during both fetal and lactational life. Postnatal programming refers to the effects of events either from birth (lactational life) to adolescence or from weaning (end of lactation) to adolescence. Islets are most plastic during the early life course; hence programming during fetal and lactational life is most potent. High fat (HF) programming is the maintenance on a HF diet (HFD) during critical developmental life stages that alters progeny metabolism and physiology. HF programming induces variable diabetogenic phenotypes dependent on the timing and duration of the dietary insult. Maternal obesity reinforces HF programming effects in progeny. HF programming, through acute hyperglycemia, initiates beta cell compensation. However, HF programming eventually leads to chronic hyperglycemia that triggers beta cell exhaustion, death and dysfunction. In HF programming, beta cell dysfunction often co-presents with insulin resistance. Balanced, healthy nutrition during developmental windows is critical for preserving beta cell structure and function. Thus early positive nutritional interventions that coincide with the development of beta cells may reduce the overwhelming burden of diabetes and metabolic disease. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

What happened to Larsen C?

NASA Astrophysics Data System (ADS)

Rignot, E. J.; Larour, E. Y.; Scheuchl, B.; Khazendar, A.; Bamber, J. L.; Mouginot, J.

2017-12-01

In 2017, Larsen C experienced one of the largest calving events in the past century, retreating the ice front by 40 km. The rift that led to this calving event originated decades ago along the flank of Hollick-Kenyon Peninsula and stopped along a suture zone, but started progressing again in 2011 and especially 2014-2015, to eventually lead to the calving of A68. The retreat changed the ice front shape between Bawden Ice Rise and Gibbs Ice Rise from convex to concave, similar to what happened to Larsen B in the late 1990s and Larsen A in the 1980s. Following that retreat, Larsen B eventually collapsed in 2002. The calving is not driven by the traditional processes of viscous bending, hydrofracture, calving cliff failure, longitudinal stress stretching, necking of bottom crevasses joining with surface crevasses, but instead by fracture mechanics. Fracture would be facilitated by the melting of the ice mélange filling the rift, a thinning of the ice shelf, a melting of the heterogeneous marine ice column, or changes in the firn/ice column associated with warming. The ice shelf thinned from the top and below over the last decades; altimetry data from 1994 to 2014 suggesting a decrease in ice shelf thickness of 40-50 m near the zone of rupture. Changes in ocean temperature are relatively undocumented in this part of Antarctica. Air temperature has warmed by 2.4 degrees C over the last 3 decades with a return to colder conditions in recent years yet still much warmer than 30 years ago. We detect no significant change in ice shelf velocity from 2006 to 2017, including after the calving event. The calving front has now retreated within 20-30 km of the compressive arch. We analyze the ice mélange in between the rift with Operation IceBridge laser data from 2009 to 2016 and radio echo sounding data from OIB CreSIS sounder since 2009 to detect changes in ice mélange and marine ice composition. We conclude on how the loss of structural rigidity has lead - or not - to the propagation of the rift beyond its natural range in the mid 2010s and what magnitude ocean warming would have been necessary to explain this change. This work was performed under a contract with NASA Cryosphere Program.

Eventual sport performance level: What about the role of type of sport, perception of critical life events, and practice quality?

PubMed

Toering, Tynke

2017-01-01

The target article describes an interesting study, which provides some challenging findings regarding athletes' pathway to excellence. The suggested links between critical life events, need for success, personal characteristics, and eventual performance level make sense from a psychodynamic perspective. This commentary will discuss some critical points related to the application of the findings in talent identification and -development programs. These are (1) the possible effect of the selection of participants on the results (including the impact of dependence on others for team sport athletes and the opportunity for multiple medal attainment), (2) a lack of detail in the description of how the athletes approached the critical life events (the perception of an event may contribute more to development than the event itself), and (3) a lack of detail in the description of the practice process throughout development. Some interesting differences were found in the motivation for and approach to practice, but little detail was given about what the athletes exactly were doing at the time. The concept of self-regulated learning may be useful in explaining how super-elite athletes action their goals through quality practice. © 2017 Elsevier B.V. All rights reserved.

HIP collapse. Don't blame doctors & patients.

PubMed

Sinagra, J

1999-11-01

While HIP's eventual insolvency was the culmination of several years of financial deterioration, certain events caused this to accelerate. This event is a long overdue impetus for change. The state has learned some hard lessons from the HIP/PHP debacle. The authors proposes a package of bills that will avoid a repeat of this issue.

Recapitulating Human Gastric Cancer Pathogenesis: Experimental Models of Gastric Cancer

PubMed Central

Ding, Lin; El Zaatari, Mohamad

2017-01-01

Overview Gastric cancer has been traditionally defined by the Correa paradigm as a progression of sequential pathological events that begins with chronic inflammation [1]. Infection with Helicobacter pylori (H. pylori) is the typical explanation for why the stomach becomes chronically inflamed. Acute gastric inflammation then leads to chronic gastritis, atrophy particularly of acid-secreting parietal cells, metaplasia due to mucous neck cell expansion from trans-differentiation of zymogenic cells to dysplasia and eventually carcinoma [2]. The chapter contains an overview of gastric anatomy and physiology to set the stage for signaling pathways that play a role in gastric tumorigenesis. Finally, the major known mouse models of gastric transformation are critiqued in terms of the rationale behind their generation and contribution to our understanding of human cancer subtypes. PMID:27573785

GLUT4 trafficking in insulin-sensitive cells. A morphological review.

PubMed

Martin, S; Slot, J W; James, D E

1999-01-01

In recent years, there have been major advances in the understanding of both the cell biology of vesicle trafficking between intracellular compartments and the molecular targeting signals intrinsic to the trafficking proteins themselves. One system to which these advances have been profitably applied is the regulation of the trafficking of a glucose transporter, GLUT4, from intracellular compartment(s) to the cell surface in response to insulin. The unique nature of the trafficking of GLUT4 and its expression in highly differentiated cells makes this a question of considerable interest to cell biologists. Unraveling the tangled web of molecular events coordinating GLUT4 trafficking will eventually lead to a greater understanding of mammalian glucose metabolism, as well as fundamental cell biological principles related to organelle biogenesis and protein trafficking.

Th2 and Th1 Responses: Clear and Hidden Sides of Immunity Against Intestinal Helminths.

PubMed

Cortés, Alba; Muñoz-Antoli, Carla; Esteban, J Guillermo; Toledo, Rafael

2017-09-01

Intestinal helminthiases affect millions of people worldwide, mainly in developing regions, where they cause a significant negative impact on human health and socioeconomic growth of affected populations. However, intestinal helminthiases are still among the most neglected tropical diseases. Protective immunity against intestinal helminths is associated with development of type 2 responses. Nevertheless, in some host-intestinal helminth combinations, local Th1 responses are initiated, inducing chronicity. The usage of helminth-mouse models is useful for elucidating the mechanisms behind the initiation of each type of response. Herein, the current knowledge on these topics is reviewed, paying particular attention to the earliest events of the immune cascade which eventually lead to either susceptibility or resistance to infection. Copyright © 2017 Elsevier Ltd. All rights reserved.

VIGILANCE POISON: Illegal poisoning and lead intoxication are the main factors affecting avian scavenger survival in the Pyrenees (France).

PubMed

Berny, Philippe; Vilagines, Lydia; Cugnasse, Jean-Marc; Mastain, Olivier; Chollet, Jean-Yves; Joncour, Guy; Razin, Martine

2015-08-01

A specific surveillance program has been set up to monitor avian scavenger populations in the French Pyrenean Mountains, hosting a high proportion of the French populations. The two main purposes of the study were to identify all causes of death and to investigate poisoning cases. All 170 birds found dead during the 7-year program were submitted to full necropsy, X-Ray, parasitological investigations and consistent analytical toxicology screenings (Cholinesterase inhibitors, anticoagulant rodenticides, organochlorine insecticides, Pb, Cd). Over the study period, 8 Bearded Vultures, 120 Griffon Vultures, 8 Egyptian Vultures and 34 Red kites were eventually collected. Mortality events were often multifactorial, but poisoning was by far the most common cause of death (24.1%), followed by trauma/fall (12%), bacterial diseases and starvation (8%) and electrocution (6%). Illicit use of banned pesticides was identified as a common cause of poisoning (53% of all poisoning cases) and lead poisoning was also identified as a significant toxicant issue (17% of all poisoning cases). Lead isotopic signature could be associated primarily with ammunition. Last, a positive association between trauma and lead contamination was detected, indicating that lead could be a significant contributor to different causes of death. These results urge for severe restrictions on the use of lead ammunition to prevent scavengers from detrimental exposure. Copyright © 2015 Elsevier Inc. All rights reserved.

Optimal management of immune-related adverse events resulting from treatment with immune checkpoint inhibitors: a review and update.

PubMed

Nagai, Hiroki; Muto, Manabu

2018-06-01

Over the last two decades, molecular-targeted agents have become mainstream treatment for many types of malignancies and have improved the overall survival of patients. However, most patients eventually develop resistance to these targeted therapies. Recently, immunotherapies such as immune checkpoint inhibitors have revolutionized the treatment paradigm for many types of malignancies. Immune checkpoint inhibitors have been approved for treatment of melanoma, non-small cell lung cancer, renal cell carcinoma, head and neck squamous cell carcinoma, Hodgkin's lymphoma, bladder cancer and gastric cancer. However, oncologists have been faced with immune-related adverse events caused by immune checkpoint inhibitors; these are generally mild but can be fatal in some cases. Because immune checkpoint inhibitors have distinct toxicity profiles from those of chemotherapy or targeted therapy, many oncologists are not familiar with the principles for optimal management of immune-related adverse events, which require early recognition and appropriate treatment without delay. To achieve this, oncologists must educate patients and health-care workers, develop checklists of appropriate tests for immune-related adverse events and collaborate closely with organ specialists. Clinical questions that remain include whether immune checkpoint inhibitors should be administered to patients with autoimmune disease and whether patients for whom immune-related adverse events lead to delays in immunotherapy should be retreated. In addition, the predicted use of combination immunotherapies in the near future means that oncologists will face a higher incidence and severity of immune-related adverse events. This review provides an overview of the optimal management of immune-related adverse events attributed to immune checkpoint inhibitors.

Effects of Cognitive-Behavioral-Theory-Based Skill-Training on University Students' Future Anxiety and Trait Anxiety

ERIC Educational Resources Information Center

Kaya, Sinem; Avci, Rasit

2016-01-01

Problem Statement: Future Anxiety (FA) and Trait Anxiety (TA) have negative effects on individuals' productivity, which can lead them to feelings of insecurity and eventually depression. Knowing more about future anxiety helps people feel more secure and produce more effectively for themselves, and eventually for society. This research examined…

Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury

PubMed Central

Fakhruddin, Selim; Alanazi, Wael

2017-01-01

Diabetes induces the onset and progression of renal injury through causing hemodynamic dysregulation along with abnormal morphological and functional nephron changes. The most important event that precedes renal injury is an increase in permeability of plasma proteins such as albumin through a damaged glomerular filtration barrier resulting in excessive urinary albumin excretion (UAE). Moreover, once enhanced UAE begins, it may advance renal injury from progression of abnormal renal hemodynamics, increased glomerular basement membrane (GBM) thickness, mesangial expansion, extracellular matrix accumulation, and glomerulosclerosis to eventual end-stage renal damage. Interestingly, all these pathological changes are predominantly driven by diabetes-induced reactive oxygen species (ROS) and abnormal downstream signaling molecules. In diabetic kidney, NADPH oxidase (enzymatic) and mitochondrial electron transport chain (nonenzymatic) are the prominent sources of ROS, which are believed to cause the onset of albuminuria followed by progression to renal damage through podocyte depletion. Chronic hyperglycemia and consequent ROS production can trigger abnormal signaling pathways involving diverse signaling mediators such as transcription factors, inflammatory cytokines, chemokines, and vasoactive substances. Persistently, increased expression and activation of these signaling molecules contribute to the irreversible functional and structural changes in the kidney resulting in critically decreased glomerular filtration rate leading to eventual renal failure. PMID:28164134

Initiation of sleep-dependent cortical-hippocampal correlations at wakefulness-sleep transition.

PubMed

Haggerty, Daniel C; Ji, Daoyun

2014-10-01

Sleep is involved in memory consolidation. Current theories propose that sleep-dependent memory consolidation requires active communication between the hippocampus and neocortex. Indeed, it is known that neuronal activities in the hippocampus and various neocortical areas are correlated during slow-wave sleep. However, transitioning from wakefulness to slow-wave sleep is a gradual process. How the hippocampal-cortical correlation is established during the wakefulness-sleep transition is unknown. By examining local field potentials and multiunit activities in the rat hippocampus and visual cortex, we show that the wakefulness-sleep transition is characterized by sharp-wave ripple events in the hippocampus and high-voltage spike-wave events in the cortex, both of which are accompanied by highly synchronized multiunit activities in the corresponding area. Hippocampal ripple events occur earlier than the cortical high-voltage spike-wave events, and hippocampal ripple incidence is attenuated by the onset of cortical high-voltage spike waves. This attenuation leads to a temporary weak correlation in the hippocampal-cortical multiunit activities, which eventually evolves to a strong correlation as the brain enters slow-wave sleep. The results suggest that the hippocampal-cortical correlation is established through a concerted, two-step state change that first synchronizes the neuronal firing within each brain area and then couples the synchronized activities between the two regions. Copyright © 2014 the American Physiological Society.

Dilatancy of Shear Transformations in a Colloidal Glass

NASA Astrophysics Data System (ADS)

Lu, Y. Z.; Jiang, M. Q.; Lu, X.; Qin, Z. X.; Huang, Y. J.; Shen, J.

2018-01-01

Shear transformations, as fundamental rearrangement events operating in local regions, hold the key of plastic flow of amorphous solids. Despite their importance, the dynamic features of shear transformations are far from clear, which is the focus of the present study. Here, we use a colloidal glass under shear as the prototype to directly observe the shear-transformation events in real space. By tracing the colloidal-particle rearrangements, we quantitatively determine two basic properties of shear transformations: local shear strain and dilatation (or free volume). It is revealed that the local free volume undergoes a significantly temporary increase prior to shear transformations, eventually leading to a jump of local shear strain. We clearly demonstrate that shear transformations have no memory of the initial free volume of local regions. Instead, their emergence strongly depends on the dilatancy ability of these local regions, i.e., the dynamic creation of free volume. More specifically, the particles processing the high dilatancy ability directly participate in subsequent shear transformations. These results experimentally enrich Argon's statement about the dilatancy nature of shear transformations and also shed insight into the structural origin of amorphous plasticity.

Methodology for Collision Risk Assessment of an Airspace Flow Corridor Concept

NASA Astrophysics Data System (ADS)

Zhang, Yimin

This dissertation presents a methodology to estimate the collision risk associated with a future air-transportation concept called the flow corridor. The flow corridor is a Next Generation Air Transportation System (NextGen) concept to reduce congestion and increase throughput in en-route airspace. The flow corridor has the potential to increase throughput by reducing the controller workload required to manage aircraft outside the corridor and by reducing separation of aircraft within corridor. The analysis in this dissertation is a starting point for the safety analysis required by the Federal Aviation Administration (FAA) to eventually approve and implement the corridor concept. This dissertation develops a hybrid risk analysis methodology that combines Monte Carlo simulation with dynamic event tree analysis. The analysis captures the unique characteristics of the flow corridor concept, including self-separation within the corridor, lane change maneuvers, speed adjustments, and the automated separation assurance system. Monte Carlo simulation is used to model the movement of aircraft in the flow corridor and to identify precursor events that might lead to a collision. Since these precursor events are not rare, standard Monte Carlo simulation can be used to estimate these occurrence rates. Dynamic event trees are then used to model the subsequent series of events that may lead to collision. When two aircraft are on course for a near-mid-air collision (NMAC), the on-board automated separation assurance system provides a series of safety layers to prevent the impending NNAC or collision. Dynamic event trees are used to evaluate the potential failures of these layers in order to estimate the rare-event collision probabilities. The results show that the throughput can be increased by reducing separation to 2 nautical miles while maintaining the current level of safety. A sensitivity analysis shows that the most critical parameters in the model related to the overall collision probability are the minimum separation, the probability that both flights fail to respond to traffic collision avoidance system, the probability that an NMAC results in a collision, the failure probability of the automatic dependent surveillance broadcast in receiver, and the conflict detection probability.

Constraining the trigger for an ancient warming episode

NASA Astrophysics Data System (ADS)

Schultz, Colin

2011-08-01

The Paleocene epoch (˜66-56 million years ago) was sandwiched between sudden climate shifts and mass extinctions. The boundary between the end of the Paleocene and the beginning of the Eocene (the P-E boundary) saw the global average temperature soar by 5°C over a few thousand years, leading to a pronounced reorganization of both terrestrial and oceanic plant and animal communities. The P-E boundary warming was triggered by an influx of atmospheric carbon dioxide, but the influx's ultimate trigger is still being debated. Other prominent warming events within the Paleogene (˜66-23 million years ago), the broad time span that encompasses the Paleocene and Eocene, have been linked to regularly recurring changes in the eccentricity of the Earth's orbit that take place on 100,000- and 405,000-year cycles. Proponents of this view suggest that an alignment of the two cycles could lead to the warming of deep ocean waters, melting frozen methane and triggering an increase in atmospheric carbon dioxide. However, some studies have suggested that the P-E boundary warming was instead the product of geological processes, where carbon-rich rocks were baked by injected magma, which eventually liberated the carbon to the atmosphere. Deciding between proposed explanations for the cause of the P-E warming, whether they are astronomical or geological, depends on accurately pinning the event in time. (Geochemistry, Geophysics, Geosystems, doi:10.1029/2010GC003426, 2011)

Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stress.

PubMed

Choi, Dong-Hee; Kim, Ji-Hye; Seo, Joo-Ha; Lee, Jongmin; Choi, Wahn Soo; Kim, Yoon-Seong

2014-01-01

In the present study we investigated the interplay between matrix metalloproteinase 3 (MMP3) and NADPH oxidase 1 (Nox1) in the process of dopamine (DA) neuronal death. We found that MMP3 activation causes the induction of Nox1 via mitochondrial reactive oxygen species (ROS) production and subsequently Rac1 activation, eventually leading to Nox1-derived superoxide generation in a rat DA neuronal N27 cells exposed to 6-OHDA. While a MMP3 inhibitor, NNGH, largely attenuated mitochondrial ROS and subsequent Nox1 induction, both apocynin, a putative Nox inhibitor and GKT137831, a Nox1 selective inhibitor failed to reduce 6-OHDA-induced mitochondrial ROS. However, both inhibitors for MMP3 and Nox1 similarly attenuated 6-OHDA-induced N27 cell death. RNAi-mediated selective inhibition of MMP3 or Nox1 showed that knockdown of either MMP3 or Nox1 significantly reduced 6-OHDA-induced ROS generation in N27 cells. While 6-OHDA-induced Nox1 was abolished by MMP3 knockdown, Nox1 knockdown did not alter MMP3 expression. Direct overexpression of autoactivated MMP3 (actMMP3) in N27 cells or in rat substantia nigra (SN) increased expression of Nox1. Selective knockdown of Nox1 in the SN achieved by adeno-associated virus-mediated overexpression of Nox1-specific shRNA largely attenuated the actMMP3-mediated dopaminergic neuronal loss. Furthermore, Nox1 expression was significantly attenuated in Mmp3 null mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Together we established novel molecular mechanisms underlying oxidative stress-mediated dopaminergic neuronal death in which MMP3 activation is a key upstream event that leads to mitochondrial ROS, Nox1 induction and eventual dopaminergic neuronal death. Our findings may lead to the development of novel therapeutic approach.

Pathophysiology of primary open-angle glaucoma from a neuroinflammatory and neurotoxicity perspective: a review of the literature.

PubMed

Evangelho, Karine; Mogilevskaya, Maria; Losada-Barragan, Monica; Vargas-Sanchez, Jeinny Karina

2017-12-30

Glaucoma is the leading cause of blindness in humans, affecting 2% of the population. This disorder can be classified into various types including primary, secondary, glaucoma with angle closure and with open angle. The prevalence of distinct types of glaucoma differs for each particular region of the world. One of the most common types of this disease is primary open-angle glaucoma (POAG), which is a complex inherited disorder characterized by progressive retinal ganglion cell death, optic nerve head excavation and visual field loss. Nowadays, POAG is considered an optic neuropathy, while intraocular pressure is proposed to play a fundamental role in its pathophysiology and especially in optic disk damage. However, the exact mechanism of optic nerve head damage remains a topic of debate. This literature review aims to bring together the information on the pathophysiology of primary open-angle glaucoma, particularly focusing on neuroinflammatory mechanisms leading to the death of the retinal ganglion cell. A literature search was done on PubMed using key words including primary open-angle glaucoma, retinal ganglion cells, Müller cells, glutamate, glial cells, ischemia, hypoxia, exitotoxicity, neuroinflammation, axotomy and neurotrophic factors. The literature was reviewed to collect the information published about the pathophysiologic mechanisms of RGC death in the POAG, from a neuroinflammatory and neurotoxicity perspective. Proposed mechanisms for glaucomatous damage are a result of pressure in RGC followed by ischemia, hypoxia of the ONH, and consequently death due to glutamate-induced excitotoxicity, deprivation of energy and oxygen, increase in levels of inflammatory mediators and alteration of trophic factors flow. These events lead to blockage of anterograde and retrograde axonal transport with ensuing axotomy and eventually blindness. The damage to ganglion cells and eventually glaucomatous injury can occur via various mechanisms including baric trauma, ischemia and impact of metabolic toxins, which triggers an inflammatory process and secondary degeneration in the ONH.

Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer

PubMed Central

Schietinger, Andrea; Arina, Ainhoa; Liu, Rebecca B; Wells, Sam; Huang, Jianhua; Engels, Boris; Bindokas, Vytas; Bartkowiak, Todd; Lee, David; Herrmann, Andreas; Piston, David W; Pittet, Mikael J; Lin, P Charles; Zal, Tomasz; Schreiber, Hans

2013-01-01

A fluorescence-based, high-resolution imaging approach was used to visualize longitudinally the cellular events unfolding during T cell-mediated tumor destruction. The dynamic interplay of T cells, cancer cells, cancer antigen loss variants, and stromal cells—all color-coded in vivo—was analyzed in established, solid tumors that had developed behind windows implanted on the backs of mice. Events could be followed repeatedly within precisely the same tumor region—before, during and after adoptive T cell therapy—thereby enabling for the first time a longitudinal in vivo evaluation of protracted events, an analysis not possible with terminal imaging of surgically exposed tumors. T cell infiltration, stromal interactions, and vessel destruction, as well as the functional consequences thereof, including the elimination of cancer cells and cancer cell variants were studied. Minimal perivascular T cell infiltrates initiated vascular destruction inside the tumor mass eventually leading to macroscopic central tumor necrosis. Prolonged engagement of T cells with tumor antigen-crosspresenting stromal cells correlated with high IFNγ cytokine release and bystander elimination of antigen-negative cancer cells. The high-resolution, longitudinal, in vivo imaging approach described here will help to further a better mechanistic understanding of tumor eradication by T cells and other anti-cancer therapies. PMID:24482750

AMOS Galaxy 15 Satellite Observations and Analysis

NASA Astrophysics Data System (ADS)

Hall, D.

2011-09-01

In early April 2010, the Galaxy 15 geosynchronous satellite experienced an on-orbit anomaly. Even though the satellite's transmitters and articulating solar panel were still functioning, ground controllers lost the ability to command and maneuver the satellite. With its orbital position no longer maintained, Galaxy 15 began to drift eastward. This forced several other satellites to make collision avoidance maneuvers during the following months. Soon after the initial anomaly, Galaxy 15's operators predicted that the satellite’s reaction wheels would eventually become saturated, causing a loss of both spacecraft attitude and proper sunward orientation of the solar panels. This "off-pointing" event finally occurred in late December, ultimately leading to a depletion of Galaxy 15's batteries. This near-death experience had a fortunate side effect, however, in that it forced the satellite’s command unit to reboot and once again be able to both receive and execute ground commands. The satellite operators have since recovered control of the satellite. AMOS conducted non-resolved photometric observations of Galaxy 15 before, during and after these events. Similar observations were conducted of Galaxy 12, the nearly-identical replacement satellite. This presentation presents and discusses these temporal brightness signatures in detail, comparing the changing patterns in the observations to the known sequence of events.

Using Seismic and Infrasonic Data to Identify Persistent Sources

NASA Astrophysics Data System (ADS)

Nava, S.; Brogan, R.

2014-12-01

Data from seismic and infrasound sensors were combined to aid in the identification of persistent sources such as mining-related explosions. It is of interest to operators of seismic networks to identify these signals in their event catalogs. Acoustic signals below the threshold of human hearing, in the frequency range of ~0.01 to 20 Hz are classified as infrasound. Persistent signal sources are useful as ground truth data for the study of atmospheric infrasound signal propagation, identification of manmade versus naturally occurring seismic sources, and other studies. By using signals emanating from the same location, propagation studies, for example, can be conducted using a variety of atmospheric conditions, leading to improvements to the modeling process for eventual use where the source is not known. We present results from several studies to identify ground truth sources using both seismic and infrasound data.

Libyan nationalizations: TOPCO/CALASIATIC vs Libya arbitration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Von Mehren, R.B.; Kourides, P.N.

1979-01-01

Nine international oil companies operating in Libya were informed in 1973 and early 1974 that their interests and properties would be nationalized. This event followed four years after a military takeover of the Libyan government by Colonel Muammar el-Qadhafi, whose actions led to a major international arbitration. This article describes the background of the Libyan nationalization, the steps toward arbitration, the arbitration proceeding, the awards of the Sole Arbitrator, and the significance of those awards. The TOPCO/CALASIATIC vs Libya arbitration not only provides an excellent example of the process of arbitration, but also it confirms the effectiveness of the processmore » in leading to eventual settlement of the dispute. Basic fundamental principles of law were considered, articulated, and reaffirmed throughout the process, adding percedent to the small body of international case law. 38 references.« less

FDA's proposed rules on patent listing requirements for new drug and 30-month stays on ANDA approval (proposed Oct. 24, 2002).

PubMed

Hui, Yuk Fung

2003-01-01

In order to close the loophole in the generic drug approval process that allows a brand name drug patent holder to delay or defeat generic drug application merely by technicality, the FDA recently proposed to modify its regulations. Those proposals affect the patent listing requirements of a new drug application, and the duration of time that a generic drug application could be put on hold in the event of a patent infringement suit. With the modified rules, the FDA expects to see an increase in the availability of generic drugs, which eventually will lead to lower drug costs. Ms. Hui discusses the contents of the proposed regulations and provides an analysis of the proposed rule's legal authority, implications on patent rights, and impact on the pharmaceutical industry.

CONSOLIDATING AND CRUSHING EXOPLANETS: DID IT HAPPEN HERE?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Volk, Kathryn; Gladman, Brett

2015-06-20

The Kepler mission results indicate that systems of tightly packed inner planets (STIPs) are present around of order 5% of FGK field stars (whose median age is ∼5 Gyr). We propose that STIPs initially surrounded nearly all such stars, and those observed are the final survivors of a process in which long-term metastability eventually ceases and the systems proceed to collisional consolidation or destruction, losing roughly equal fractions of systems every decade in time. In this context, we also propose that our solar system initially contained additional large planets interior to the current orbit of Venus, which survived in amore » metastable dynamical configuration for 1%–10% of the solar system’s age. Long-term gravitational perturbations caused the system orbits to cross, leading to a cataclysmic event that left Mercury as the sole surviving relic.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andrew, S.E.; Goldberg, Y.P.; Squitieri, F.

Huntington disease (HD) is one of 7 disorders now known to be caused by expansion of a trinucleotide repeat. The HD mutation is a polymorphic trinucleotide (CAG) repeat in the 5{prime} region of a novel gene that expands beyond the normal range of 10-35 repeats in persons destined to develop the disease. Haplotype analysis of other dynamic mutation disorders such as myotonic dystrophy and Fragil X have suggested that a rare ancestral expansion event on a normal chromosome is followed by subsequent expansion events, resulting in a pool of chromosomes in the premutation range, which is inherently unstable and pronemore » to further multiple expansion events leading to disease range chromosomes. Haplotype analysis of 67 HD and 84 control chromosomes using 5 polymorphic markers, both intragenic and 5{prime} to the disease mutation, demonstrate that multiple haplotypes underlie HD. However, 94% of the chromosomes can be grouped under two major haplotypes. These two haplotypes are also present in the normal population. A third major haplotype is seen on 38% of normal chromosomes but rarely on HD chromosomes (6%). CAG lengths on the normal chromosomes with the two haplotypes seen in the HD population are higher than those seen on the normal chromosomes with the haplotype rarely seen on HD chromosomes. Furthermore, in populations with a diminished frequency of HD, CAG length on normal chromosomes is significantly less than other populations with higher prevalence rates for HD. These data suggest that CAG length on normal chromosomes may be a significant factor contributing to repeat instability that eventually leads to chromosomes with CAG repeat lengths in the HD range. Haplotypes on the HD chromosomes are identical to those normal chromosomes which have CAG lengths in the high range of normal, suggesting that further expansions of this pool of chromosomes leads to chromosomes with CAG repeat sizes within the disease range, consistent with a multistep model.« less

Supercontinental warming of the mantle at the origin of gigantic flood basalts

NASA Astrophysics Data System (ADS)

Coltice, N.; Phillips, B. R.; Bertrand, H.; Ricard, Y.; Rey, P.

2006-12-01

Continents episodically cluster together into a supercontinent, eventually breaking up with intense magmatic activity supposedly causedby mantle plumes. The break-up of Pangea, the last supercontinent, was accompanied by the emplacement of the largest known continental flood basalt, the Central Atlantic Magmatic Province, causing massive extinctions at the Triassic/Jurassic boundary. However, there is little support for a plume origin for this catastrophic event. On the basis of 2D and 3D spherical convection modelling in a internally heated mantle, we show that continental aggregation leads to large-scale melting without requiring the involvement of plumes. When only internal heat sources in the mantle are considered, the formationof a supercontinent causes the enlargement of the wavelength of the flow and a subcontinental warming as large as 100^{\\mboxo}C. This temperature increase may lead to large- scale melting without the involvment of plumes. Our results suggest the existence of two distinct types of continental flood basalts, caused by plume or by supercontinental warming. We review some potential candidates for our proposed model.

BEAMING NEUTRINOS AND ANTI-NEUTRINOS ACROSS THE EARTH TO DISENTANGLE NEUTRINO MIXING PARAMETERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fargion, Daniele; D'Armiento, Daniele; Paggi, Paolo

2012-10-10

A result from MINOS seemed to indicate that the mass splitting and mixing angle of anti-neutrinos is different from that of neutrinos, suggesting a charge-parity-time (CPT) violation in the lepton sector. However, more recent MINOS data reduced the {nu}{sub {mu}}-{nu}-bar{sub {mu}} differences leading to a narrow discrepancy nearly compatible with no CPT violation. However, the last few years of OPERA activity on the appearance of a tau lepton (one unique event) still has not been probed and more tools may be required to disentangle a list of parameters ({mu}-{tau} flavor mixing, tau appearance, any eventual CPT violation, {theta}{sub 13} anglemore » value, and any hierarchy neutrino mass). Atmospheric anisotropy in muon neutrino spectra in the DeepCore, at ten to tens of GeV (unpublished), can hardly reveal asymmetry in the eventual {nu}{sub {mu}}-{nu}-bar{sub {mu}} oscillation parameters. Here we considered how the longest baseline neutrino oscillation available, crossing most of Earth's diameter, may improve the measurement and at best disentangle any hypothetical CPT violation occurring between the earliest (2010) and the present (2012) MINOS bounds (with 6{sigma} a year), while testing {tau} and even the appearance of {tau}-bar at the highest rate. The {nu}{sub {mu}} and {nu}-bar{sub {mu}} disappearance correlated with the tau appearance is considered for those events at the largest distances. We thus propose a beam of {nu}{sub {mu}} and {nu}-bar{sub {mu}} crossing through the Earth, within an OPERA-like experiment from CERN (or Fermilab), in the direction of the IceCube-DeepCore {nu} detector at the South Pole. The ideal energy lies at 21 GeV to test the disappearance or (for any tiny CPT violation) the partial {nu}-bar{sub {mu}} appearance. Such a tuned detection experiment may lead to a strong signature of {tau} or {tau}-bar generation even within its neutral current noise background events: nearly one {tau}-bar or two {tau} a day. The tau appearance signal is above (or within) 10{sigma} a year, even for a 1% OPERA-like experiment. Peculiar configurations for {theta}{sub 13} and the hierarchy neutrino mass test may also be better addressed by a DeepCore-PINGU array detector beaming {nu}{sub {mu}} and observing {nu}{sub e} at 6 GeV neutrino energy windows.« less

Nurses hold the key to purchasing reforms in the NHS.

PubMed

Canning, S

1994-07-13

JUST over a year ago health minster Brian Mawhinney, speaking to the Royal College of Physicians, sowed a seed which could eventually lead to the nation's nurses branching out and playing the lead role in health care purchasing.

Modal interaction in linear dynamic systems near degenerate modes

NASA Technical Reports Server (NTRS)

Afolabi, D.

1991-01-01

In various problems in structural dynamics, the eigenvalues of a linear system depend on a characteristic parameter of the system. Under certain conditions, two eigenvalues of the system approach each other as the characteristic parameter is varied, leading to modal interaction. In a system with conservative coupling, the two eigenvalues eventually repel each other, leading to the curve veering effect. In a system with nonconservative coupling, the eigenvalues continue to attract each other, eventually colliding, leading to eigenvalue degeneracy. Modal interaction is studied in linear systems with conservative and nonconservative coupling using singularity theory, sometimes known as catastrophe theory. The main result is this: eigenvalue degeneracy is a cause of instability; in systems with conservative coupling, it induces only geometric instability, whereas in systems with nonconservative coupling, eigenvalue degeneracy induces both geometric and elastic instability. Illustrative examples of mechanical systems are given.

An Old Problem: Aging and Skeletal-Muscle-Strain Injury.

PubMed

Baker, Brent A

2017-04-01

Clinical Scenario: Even though chronological aging is an inevitable phenomenological consequence occurring in every living organism, it is biological aging that may be the most significant factor challenging our quality of life. Development of functional limitations, resulting from improper maintenance and restoration of various organ systems, ultimately leads to reduced health and independence. Skeletal muscle is an organ system that, when challenged, is often injured in response to varying stimuli. Overt muscle-strain injury can be traumatic, clinically diagnosable, properly managed, and a remarkably common event, yet our contemporary understanding of how age and environmental stressors affect the initial and subsequent induction of injury and how the biological processes resulting from this event are modifiable and, eventually, lead to functional restoration and healing of skeletal muscle and adjacent tissues is presently unclear. Even though the secondary injury response to and recovery from "contraction-induced" skeletal-muscle injury are impaired with aging, there is no scientific consensus as to the exact mechanism responsible for this event. Given the multitude of investigative approaches, particular consideration given to the appropriateness of the muscle-injury model, or research paradigm, is critical so that outcomes may be physiologically relevant and translational. In this case, methods implementing stretch-shortening contractions, the most common form of muscle movements used by all mammals during physical movement, work, and activity, are highlighted. Understanding the fundamental evidence regarding how aging influences the responsivity of skeletal muscle to strain injury is vital for informing how clinicians approach and implement preventive strategies, as well as therapeutic interventions. From a practical perspective, maintaining or improving the overall health and tissue quality of skeletal muscle as one ages will positively affect skeletal muscle's safety threshold and responsivity, which may reduce incidence of injury, improve recovery time, and lessen overall fiscal burdens.

The physiology of boredom, depression and senile dementia.

PubMed

Saunders, M N

1996-05-01

Mental stimulation ensures the flow of blood, oxygen and nutrients to the brain. The stimulation can be either generated internally from thought and rumination or externally from our environment via the senses. Without this stimulation, neuron shrinkage and atrophy eventually may lead to depression and senile dementia. This paper explains why mental stimulation may be prevented from realizing its beneficial effects of increasing the blood flow to the brain. The hypothesis is based on feedback biological mechanisms that prevent overload of the neural circuitry due to excessive mental stimulation. However, if overstimulation is maintained over a long period and, with it, the overload protection process, it may eventually lead to permanent depletion of neuron connections and also neural communications.

Delayed and reduced carbon uptake in a subarctic peatland following an extreme winter event

NASA Astrophysics Data System (ADS)

Parmentier, F. J. W.; Rasse, D. P.; Lund, M.; Bjerke, J. W.; Drake, B. G.; Weldon, S.; Tømmervik, H. A.; Hansen, G.

2017-12-01

An increase in the frequency of extreme winter events in the Arctic may lead to more widespread damage to shrub-dominated ecosystems, including peatlands. In principle, such damage should reduce carbon uptake in the following summer, but the resilience of northern ecosystems to extreme winter events remains unclear due to a dearth of flux measurements from affected areas. In this talk, therefore, we report CO2 fluxes measured with eddy covariance from a peatland in northern Norway and show that vegetation productivity was delayed and reduced during the summer of 2014, following an extreme winter event. Strong frost and the absence of a protective snow cover in January of that year - its combined intensity unprecedented in the local climate record - led to severe dieback of the shrub species Calluna vulgaris and Empetrum nigrum. Similar vegetation damage was reported at the time along 1000 km of coastal Norway, indicating the widespread impact of this frost drought event. Consequently, gross primary production (GPP) showed a strong delayed response to temperature, from snowmelt up to the peak of summer, potentially reducing carbon uptake by 15 (0-24) g C m-2 ( 13% of GPP in that period). The delayed response of the vegetation was also exhibited in remotely-sensed NDVI values, with a maximum two weeks later than normal and at the lowest level in more than a decade. Photosynthesis was eventually stimulated by the warm and sunny summer, but ecosystem respiration increased as well - which limited net carbon uptake. This study shows that damage from a single extreme winter event can have a profound impact on ecosystem CO2 uptake, and it highlights the importance of including winter-induced shrub damage in terrestrial ecosystem models to accurately predict vegetation and carbon sequestration trends in the arctic and boreal region.

Comparison of the key mechanisms leading to rollovers in Liquefied Natural Gas using Computational Fluid Dynamics

NASA Astrophysics Data System (ADS)

Hubert, Antoine; Dadonau, Maksim; Dembele, Siaka; Denissenko, Petr; Wen, Jennifer

2017-11-01

Growing demand for the LNG fosters growth of the number of production sites with varying composition and density. Combining different sources of LNG may result in a stably stratified system, in which heat and mass transfer between the layers is limited. Heating of the LNG due to wall thermal conductivity leads to formation of convection cells confined within the layers. While the upper layer can release the extra energy via preferential methane boil-off, the bottom layer cannot and hence becomes superheated. Gradual density equilibration reduces stratification and may eventually lead to a sudden mixing event called ``rollover'', accompanied by violent evaporation of the superheated LNG. Three phenomena are potentially responsible for density equilibration. The first is the growing difference in thermal expansion of the layers due to the reduced ability of the bottom layer to reject heat. The second is the penetration of the heated near-wall boundary layer into the upper layer. The third is the ``entrainment mixing'' occurring at the contact surface between the two layers. The present study uses CFD to compare these mechanisms. Boussinesq approximation and an extended version of the k- ɛ model is used. The code is validated by comparison with a large-scale LNG rollover experiment.

Kissing molars: report of three cases and new prospective on aetiopathogenetic theories

PubMed Central

Menditti, Dardo; Laino, Luigi; Cicciù, Marco; Mezzogiorno, Antonio; Perillo, Letizia; Menditti, Marco; Cervino, Gabriele; Muzio, Lorenzo Lo; Baldi, Alfonso

2015-01-01

Kissing molars (KMs) is an extremely rare condition of impacted third molars, pointed in the opposite direction in a single follicular space; it consists exactly in a full impacted of permanent molars which occurs only in the lower jaw. Actually, about less than thirty cases have been reported in scientific literatures. The aetiology and pathogenesis of this pathological double dental inclusion remain unknown; above all events that lead two molars to appear, as KMs remain mysterious. The association to metabolic connective diseases such as mucopolysaccharidosis was emphasized. KMs considered as an isolated event, may be associated to an abnormal position of the tooth-bud from lower permanent molars, or fourth supernumerary tooth (distomolar). Recently, hyperplastic dental follicle (HDF), with a down regulation of matrix metal-proteinases and up regulation of several genes of collagens, has been mentioned in association with KMs. In this paper, after having analyzed three new cases of KMs that have been treated, we report a new hypothesis. This last is based on the failure in the dental follicle’s ability to initiate or continue properly resorption of the overlying alveolar bone, by many exogenous factors which may act on eruptive phase that would lead to its rotation with its contents coming out a pathological situation of KMs. The therapy of choice is related to the surgical removal of KMs through a double odontectomy with transalveolar method. Other treatments can be, eventually, orthodontic therapy of the impacted teeth and a radiological follow-up without surgery. PMID:26884840

Endocrinology of recurrent pregnancy loss.

PubMed

Arredondo, Francisco; Noble, Luis S

2006-02-01

Following implantation, the maintenance of the pregnancy is dependent on a multitude of endocrinological events that will eventually aid in the successful growth and development of the fetus. Although the great majority of pregnant women have no pre-existing endocrine abnormalities, a small number of women can have certain endocrine alterations that could potentially lead to recurrent pregnancy losses. It is estimated that approximately 8 to 12% of all pregnancy losses are the result of endocrine factors. During the preimplantation period, the uterus undergoes important developmental changes stimulated by estrogen, and more importantly, progesterone. Progesterone is essential for the successful implantation and maintenance of pregnancy. Therefore, disorders related to inadequate progesterone secretion by the corpus luteum are likely to affect the outcome of the pregnancy. Luteal phase deficiency, hyperprolactinemia, and polycystic ovarian syndrome are some examples. Several other endocrinological abnormalities such as thyroid disease, hypoparathyroidism, uncontrolled diabetes, and decreased ovarian reserve have been implicated as etiologic factors for recurrent pregnancy loss.

Michael Gottlieb Hansch (1683-1749), Ulrich Junius (1670-1726) and the attempt to edit the works and letters of Johannes Kepler. (German Title: Michael Gottlieb Hansch (1683-1749), Ulrich Junius (1670-1726) und der Versuch einer Edition der Werke und Briefe Johannes Keplers)

NASA Astrophysics Data System (ADS)

Döring, Detlef

Johannes Kepler's manuscripts which remained after his death suffered a troubled fate. It was not possible to collect them in Germany and to work with them systematically, because their importance was strikingly underestimated. Only at the beginning of the 18th century U. Junius in Leipzig tried unsuccessfully to collect and to publish the most important manuscripts. Afterwards M.G. Hansch took up this plan and pursued it until the end of his life. However, the only result was one volume with unpublished letters which appeared in 1718. The hoped-for collected works could not be realized. These events are described in detail, especially the efforts of Junius and Hansch as well as the opposition which eventually lead to a failure of both attempts.

Summary of events and geotechnical factors leading to decommissioning of the Strategic Petroleum Reserve (SPR) facility at Weeks Island, Louisiana

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neal, J.T.; Bauer, S.J.; Ehgartner, B.L.

1996-10-01

A sinkhole discovered over the edge of the Strategic Petroleum Reserve storage facility at Weeks Island salt dome, Louisiana, led to decommissioning the site during 1995--1998, following extensive diagnostics in 1994. The sinkhole resulted from mine-induced fractures in the salt which took may years to develop, eventually causing fresh water to leak into the storage chamber and dissolve the overlying salt, thus causing overburden collapse into the void. Prior to initiating the oil removal, a freeze wall was constructed at depth around the sinkhole in 1995 to prevent water inflow; a freeze plug will remain in place until the minemore » is backfilled with brine in 1997--8, and stability is reached. Residual oil will be removed; environmental monitoring has been initiated and will continue until the facility is completely plugged and abandoned, and environmental surety is achieved.« less

Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment.

PubMed

Bayer, T A; Wirths, O

2008-02-01

Accumulating evidence points to an important role of intraneuronal Abeta as a trigger of the pathological cascade of events leading to neurodegeneration and eventually to Alzheimer's disease (AD) with its typical clinical symptoms, like memory impairment and change in personality. As a new concept, intraneuronal accumulation of Abeta instead of extracellular Abeta deposition has been introduced to be the disease-triggering event in AD. The present review compiles current knowledge on the amyloid precursor protein (APP)/PS1KI mouse model with early and massive intraneuronal Abeta42 accumulation: (1) The APP/PS1KI mouse model exhibits early robust brain and spinal cord axonal degeneration and hippocampal CA1 neuron loss. (2) At the same time-point, a dramatic, age-dependent reduced ability to perform working memory and motor tasks is observed. (3) The APP/PS1KI mice are smaller and show development of a thoracolumbar kyphosis, together with an incremental loss of body weight. (4) Onset of the observed behavioral alterations correlates well with robust axonal degeneration in brain and spinal cord and with abundant hippocampal CA1 neuron loss.

High level of microsynteny and purifying selection affect the evolution of WRKY family in Gramineae.

PubMed

Jin, Jing; Kong, Jingjing; Qiu, Jianle; Zhu, Huasheng; Peng, Yuancheng; Jiang, Haiyang

2016-01-01

The WRKY gene family, which encodes proteins in the regulation processes of diverse developmental stages, is one of the largest families of transcription factors in higher plants. In this study, by searching for interspecies gene colinearity (microsynteny) and dating the age distributions of duplicated genes, we found 35 chromosomal segments of subgroup I genes of WRKY family (WRKY I) in four Gramineae species (Brachypodium, rice, sorghum, and maize) formed eight orthologous groups. After a stepwise gene-by-gene reciprocal comparison of all the protein sequences in the WRKY I gene flanking areas, highly conserved regions of microsynteny were found in the four Gramineae species. Most gene pairs showed conserved orientation within syntenic genome regions. Furthermore, tandem duplication events played the leading role in gene expansion. Eventually, environmental selection pressure analysis indicated strong purifying selection for the WRKY I genes in Gramineae, which may have been followed by gene loss and rearrangement. The results presented in this study provide basic information of Gramineae WRKY I genes and form the foundation for future functional studies of these genes. High level of microsynteny in the four grass species provides further evidence that a large-scale genome duplication event predated speciation.

Alterations in tendon microenvironment in response to mechanical load: potential molecular targets for treatment strategies

PubMed Central

Fouda, Mohamed B; Thankam, Finosh G; Dilisio, Matthew F; Agrawal, Devendra K

2017-01-01

Rotator cuff (RC) tendons could beinflicted in many ways with an eventual outcome of pain, weakness and disability, which represent a large burden on health care cost. However, optimal healing, either conservatively or with surgical intervention, remains an issue that needs further investigation. Disorders of the RC tendons may result from external factors like trauma, or internal factors through physiologic and metabolic derangement. Most RC tendon disorders may be asymptomatic and may result from an over-activity of the inflicted shoulder and its tendons. Such tendon disorders are poorly diagnosed since patients do not seek medical attention until pain or weakness ensue. Immunological and biochemical events in RC disorders due to mechanical intolerance have not been investigated. Generally, the mechanical load drives normal physiological properties of the tendon. But, mechanical overload/burden exerts stress on tenocytes, and disrupts the tendon microenvironment by triggering a multitude of signaling pathways leading to extracellular matrix remodeling, disorganization, alteration in collagen composition and apoptosis. These events result in weak tendon which is highly susceptible to rupture or tear. In this article, we critically reviewed the intrinsic signaling pathways that are excessively triggered by continuous mechanical load and the counteracting physiological responses and associated derangements. The elucidation of the molecular events underlying mechanical stress-induced symptomatic/asymptomatic tendinopathy could provide information on potential target sites for translational application in the management of rotator cuff disorders. PMID:29118899

To the Right of Constructive Engagement: An Alternative Approach toward South Africa.

DTIC Science & Technology

1986-03-05

northward or intermarried with the Europeans. As those forebears of today’s Afrikaner moved to the Northeast, they eventually came into contact with Bantu...now South Africa consisted of two independent Afrikaner republics, the Orange Free 4..| State and the Transvaal, the British-ruled Cape Colony and...all over the world. Britain attempted to establish authority over the Afrikaner Republics eventually leading to the Boer War. In 1910 the Union of South

HFT events - Shallow moonquakes. [High-Frequency Teleseismic

NASA Technical Reports Server (NTRS)

Nakamura, Y.

1977-01-01

A few large distant seismic events of distinctly high signal frequency, designated HFT (high-frequency teleseismic) events, are observed yearly by the Apollo lunar seismic network. Their sources are located on or near the surface of the moon, leaving a large gap in seismic activity between the zones of HFT sources and deep moonquakes. No strong regularities are found in either their spatial or temporal distributions. Several working hypotheses for the identity of these sources have advanced, but many characteristics of the events seem to favor a hypothesis that they are shallow moonquakes. Simultaneous observations of other lunar phenomena may eventually enable the determination of their true identity.

An Overview of Recent Advances in Event-Triggered Consensus of Multiagent Systems.

PubMed

Ding, Lei; Han, Qing-Long; Ge, Xiaohua; Zhang, Xian-Ming

2018-04-01

Event-triggered consensus of multiagent systems (MASs) has attracted tremendous attention from both theoretical and practical perspectives due to the fact that it enables all agents eventually to reach an agreement upon a common quantity of interest while significantly alleviating utilization of communication and computation resources. This paper aims to provide an overview of recent advances in event-triggered consensus of MASs. First, a basic framework of multiagent event-triggered operational mechanisms is established. Second, representative results and methodologies reported in the literature are reviewed and some in-depth analysis is made on several event-triggered schemes, including event-based sampling schemes, model-based event-triggered schemes, sampled-data-based event-triggered schemes, and self-triggered sampling schemes. Third, two examples are outlined to show applicability of event-triggered consensus in power sharing of microgrids and formation control of multirobot systems, respectively. Finally, some challenging issues on event-triggered consensus are proposed for future research.

U-Pb dating and emplacement history of granitoid plutons in the northern Sanandaj-Sirjan Zone, Iran

NASA Astrophysics Data System (ADS)

Mahmoudi, Shahryar; Corfu, Fernando; Masoudi, Fariborz; Mehrabi, Behzad; Mohajjel, Mohammad

2011-05-01

The Sanandaj-Sirjan Zone (SSZ), which runs parallel to the Zagros fold and thrust belt of Iran, underwent a multistage evolution starting with Neotethys initiation, its subsequent subduction below the Iranian continental crust, and eventual closure during convergence of Arabia towards central Iran. Plutonic complexes are well developed in the northern part of the SSZ and we have dated a number of them by ID-TIMS U-Pb on zircon. The new data record the following events: a Mid Jurassic period that formed the Boroujerd Plutonic Complex (169 Ma), the Astaneh Pluton (168 Ma) and the Alvand Pluton (165 Ma); Late Jurassic emplacement of the Gorveh Pluton (157-149 Ma); Mid Cretaceous (109 Ma) formation of a I-type phase in the Hasan Salary Pluton near Saqqez, followed by Early Paleocene (60 Ma) intrusion of A-type granite in the same pluton; and the youngest intrusive event recorded so far in the SSZ with the intrusion of granite in the Gosheh-Tavandasht Complex near Boroujerd at 34.9 Ma. These different events reflect specific stages of subduction-related magmatism prior to the eventual Miocene collision between the two continental blocks.

Domestic Event Support Operations (DESO)

DTIC Science & Technology

2012-02-01

Examples include EOD Technicians, doctors, nurses , and signalers. The capability also needed dedicated support from DSTO, which eventually became...attacks led to the postponement of CHOGM 2001 and the suspension of Operation GUARDIAN. The activity was rescheduled for March 2002 to be held in the

The Moon as a 100% Isolation Barrier for Earth During Exobiological Examination of Solar System Sample Return Missions

NASA Astrophysics Data System (ADS)

DiGregorio, B. E.

2018-04-01

The only 100% guarantee of protecting Earth's biosphere from a hazardous back contamination event is to use the Moon as a sample return examination facility to qualify samples for eventual return to Earth.

The Moon: A 100% Isolation Barrier for Earth During Exobiological Examination of Solar System Sample Return Missions

NASA Astrophysics Data System (ADS)

DiGregorio, B. E.

2018-02-01

The only 100% guarantee of protecting our planet's biosphere from a back contamination event is to use the Moon as a sample return examination facility to qualify samples for eventual return to Earth.

Molecular mechanisms of aging and immune system regulation in Drosophila.

PubMed

Eleftherianos, Ioannis; Castillo, Julio Cesar

2012-01-01

Aging is a complex process that involves the accumulation of deleterious changes resulting in overall decline in several vital functions, leading to the progressive deterioration in physiological condition of the organism and eventually causing disease and death. The immune system is the most important host-defense mechanism in humans and is also highly conserved in insects. Extensive research in vertebrates has concluded that aging of the immune function results in increased susceptibility to infectious disease and chronic inflammation. Over the years, interest has grown in studying the molecular interaction between aging and the immune response to pathogenic infections. The fruit fly Drosophila melanogaster is an excellent model system for dissecting the genetic and genomic basis of important biological processes, such as aging and the innate immune system, and deciphering parallel mechanisms in vertebrate animals. Here, we review the recent advances in the identification of key players modulating the relationship between molecular aging networks and immune signal transduction pathways in the fly. Understanding the details of the molecular events involved in aging and immune system regulation will potentially lead to the development of strategies for decreasing the impact of age-related diseases, thus improving human health and life span.

Molecular Mechanisms of Aging and Immune System Regulation in Drosophila

PubMed Central

Eleftherianos, Ioannis; Castillo, Julio Cesar

2012-01-01

Aging is a complex process that involves the accumulation of deleterious changes resulting in overall decline in several vital functions, leading to the progressive deterioration in physiological condition of the organism and eventually causing disease and death. The immune system is the most important host-defense mechanism in humans and is also highly conserved in insects. Extensive research in vertebrates has concluded that aging of the immune function results in increased susceptibility to infectious disease and chronic inflammation. Over the years, interest has grown in studying the molecular interaction between aging and the immune response to pathogenic infections. The fruit fly Drosophila melanogaster is an excellent model system for dissecting the genetic and genomic basis of important biological processes, such as aging and the innate immune system, and deciphering parallel mechanisms in vertebrate animals. Here, we review the recent advances in the identification of key players modulating the relationship between molecular aging networks and immune signal transduction pathways in the fly. Understanding the details of the molecular events involved in aging and immune system regulation will potentially lead to the development of strategies for decreasing the impact of age-related diseases, thus improving human health and life span. PMID:22949833

Cardiovascular involvement in systemic rheumatic diseases: An integrated view for the treating physicians.

PubMed

Lee, Kwang Seob; Kronbichler, Andreas; Eisenhut, Michael; Lee, Keum Hwa; Shin, Jae Il

2018-03-01

Systemic autoimmune diseases can affect various kinds of organs including the kidney, the skin, soft tissue and the bone. Among others, cardiovascular involvement in rheumatic diseases has been shown to affect myocardium, pericardium, cardiac vessels, conduction system and valves, eventually leading to increased mortality. In general, underlying chronic inflammation leads to premature atherosclerosis, but also other manifestations such as arrhythmia and heart failure may have a 'silent' progress. Traditional cardiovascular risk factors play a secondary role, while disease-specific factors (i.e. disease duration, severity, antibody positivity, persistent disease activity) can directly influence the cardiovascular system. Therefore, early diagnosis is critical to optimize management and to control inflammatory activity and recent data suggest that risk factors (i.e. hypercholesterolemia and hypertension) need intensive treatment as well. With the advent of immunosuppressive agents, most rheumatic diseases are well controlled on treatment, but information related to their cardioprotective efficacy is not well-defined. In this review, we focus on cardiovascular involvement in rheumatic diseases and highlight current evidence which should be of help for the treating physicians. Moreover, cardiotoxicity of immunosuppressive drugs is a rare issue and such potential adverse events will be briefly discussed. Copyright © 2018. Published by Elsevier B.V.

Human Resources: Solving Work and Life Challenges

ERIC Educational Resources Information Center

Bartley, Sharon Jeffcoat

2003-01-01

Work-life issues are those problems employees have that impact their ability to perform their work and may lead to increasing levels of stress. Stress over time can lead to low employee morale, lower productivity, decreased job satisfaction and eventually to sickness and absenteeism. In extreme cases, stress can result in substance abuse or…

The G-Portal Digital Repository as a Potentially Disruptive Pedagogical Innovation

ERIC Educational Resources Information Center

Hedberg, John G.; Chang, Chew-Hung

2007-01-01

Christensen defined a disruptive innovation or technology as one that eventually takes over the existing dominant technology in the market, despite the fact that the disruptive technology is both radically different to the leading technology and often initially performs worse than the leading technology according to existing measures of…

Glaucoma (image)

MedlinePlus

Glaucoma is a condition of increased fluid pressure inside the eye. The increased pressure causes compression of ... nerve which can eventually lead to nerve damage. Glaucoma can cause partial vision loss, with blindness as ...

Evaporation-Triggered Segregation of Sessile Binary Droplets.

PubMed

Li, Yaxing; Lv, Pengyu; Diddens, Christian; Tan, Huanshu; Wijshoff, Herman; Versluis, Michel; Lohse, Detlef

2018-06-01

Droplet evaporation of multicomponent droplets is essential for various physiochemical applications, e.g., in inkjet printing, spray cooling, and microfabrication. In this work, we observe and study the phase segregation of an evaporating sessile binary droplet, consisting of a miscible mixture of water and a surfactantlike liquid (1,2-hexanediol). The phase segregation (i.e., demixing) leads to a reduced water evaporation rate of the droplet, and eventually the evaporation process ceases due to shielding of the water by the nonvolatile 1,2-hexanediol. Visualizations of the flow field by particle image velocimetry and numerical simulations reveal that the timescale of water evaporation at the droplet rim is faster than that of the Marangoni flow, which originates from the surface tension difference between water and 1,2-hexanediol, eventually leading to segregation.

AR Sco as a possible seed of highly magnetized white dwarf

NASA Astrophysics Data System (ADS)

Mukhopadhyay, Banibrata; Rao, A. R.; Bhatia, Tanayveer Singh

2017-12-01

We explore the possibility that the recently discovered white dwarf pulsar AR Sco acquired its high spin and magnetic field due to repeated episodes of accretion and spin-down. An accreting white dwarf can lead to a larger mass and consequently a smaller radius thus causing an enhanced rotation period and a magnetic field. This spinning magnetic white dwarf temporarily can inhibit accretion, spin down and eventually, the accretion can start again due to the shrinking of the binary period by gravitational radiation. A repetition of the above cycle can eventually lead to a high magnetic field white dwarf, recently postulated to be the reason for overluminous type Ia supernovae. We also point out that these high magnetic field spinning white dwarfs are attractive sites for gravitational radiation.

Changing the threshold-Signals and mechanisms of mast cell priming.

PubMed

Halova, Ivana; Rönnberg, Elin; Draberova, Lubica; Vliagoftis, Harissios; Nilsson, Gunnar P; Draber, Petr

2018-03-01

Mast cells play a key role in allergy and other inflammatory diseases involving engagement of multivalent antigen with IgE bound to high-affinity IgE receptors (FcεRIs). Aggregation of FcεRIs on mast cells initiates a cascade of signaling events that eventually lead to degranulation, secretion of leukotrienes and prostaglandins, and cytokine and chemokine production contributing to the inflammatory response. Exposure to pro-inflammatory cytokines, chemokines, bacterial and viral products, as well as some other biological products and drugs, induces mast cell transition from the basal state into a primed one, which leads to enhanced response to IgE-antigen complexes. Mast cell priming changes the threshold for antigen-mediated activation by various mechanisms, depending on the priming agent used, which alone usually do not induce mast cell degranulation. In this review, we describe the priming processes induced in mast cells by various cytokines (stem cell factor, interleukins-4, -6 and -33), chemokines, other agents acting through G protein-coupled receptors (adenosine, prostaglandin E 2 , sphingosine-1-phosphate, and β-2-adrenergic receptor agonists), toll-like receptors, and various drugs affecting the cytoskeleton. We will review the current knowledge about the molecular mechanisms behind priming of mast cells leading to degranulation and cytokine production and discuss the biological effects of mast cell priming induced by several cytokines. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

When in Doubt, Put Them Out: Principal Perspectives on Suspension as a Disciplinary Practice

ERIC Educational Resources Information Center

Herrera, Leisa A.

2017-01-01

The subject of school discipline is one of the most critical issues facing our educational system. Disruptive student behavior interrupts teaching and learning processes and if not effectively addressed, it can manifest itself in other areas in a child's life, leading to more serious behaviors which may eventually lead to criminal involvement,…

Challenges in understanding, modelling, and mitigating Lake Outburst Flood Hazard: experiences from Central Asia

NASA Astrophysics Data System (ADS)

Mergili, Martin; Schneider, Demian; Andres, Norina; Worni, Raphael; Gruber, Fabian; Schneider, Jean F.

2010-05-01

Lake Outburst Floods can evolve from complex process chains like avalanches of rock or ice that produce flood waves in a lake which may overtop and eventually breach glacial, morainic, landslide, or artificial dams. Rising lake levels can lead to progressive incision and destabilization of a dam, to enhanced ground water flow (piping), or even to hydrostatic failure of ice dams which can cause sudden outflow of accumulated water. These events often have a highly destructive potential because a large amount of water is released in a short time, with a high capacity to erode loose debris, leading to a powerful debris flow with a long travel distance. The best-known example of a lake outburst flood is the Vajont event (Northern Italy, 1963), where a landslide rushed into an artificial lake which spilled over and caused a flood leading to almost 2000 fatalities. Hazards from the failure of landslide dams are often (not always) fairly manageable: most breaches occur in the first few days or weeks after the landslide event and the rapid construction of a spillway - though problematic - has solved some hazardous situations (e.g. in the case of Hattian landslide in 2005 in Pakistan). Older dams, like Usoi dam (Lake Sarez) in Tajikistan, are usually fairly stable, though landsildes into the lakes may create floodwaves overtopping and eventually weakening the dams. The analysis and the mitigation of glacial lake outburst flood (GLOF) hazard remains a challenge. A number of GLOFs resulting in fatalities and severe damage have occurred during the previous decades, particularly in the Himalayas and in the mountains of Central Asia (Pamir, Tien Shan). The source area is usually far away from the area of impact and events occur at very long intervals or as singularities, so that the population at risk is usually not prepared. Even though potentially hazardous lakes can be identified relatively easily with remote sensing and field work, modeling and predicting of GLOFs (and also the outburst of landslide-dammed lakes) remains a challenge: • The knowledge about the onset of the process is often limited (bathymetry of the lakes, subsurface water, properties of dam (content of ice), type of dam breach, understanding of process chains and interactions). • The size of glacial lakes may change rapidly but continuously, and many lakes break out within a short time after their development. Continuous monitoring is therefore required to keep updated on the existing hazards. • Also the outburst of small glacial lakes may lead to significant debris floods or even debris flows if there is plenty of erodible material available. • The available modeling software packages are of limited suitability for lake outburst floods: e.g. software developed by the hydrological community is specialized to simulate (debris) floods with input hydrographs on moderately steep flow channels and with lower sediment loads. In contrast to this, programs for rapid mass movements are better suited on steeper slopes and sudden onset of the movement. The typical characteristics of GLOFs are in between and vary for different channel sections. In summary, the major bottlenecks remain in deriving realistic or worst case scenarios and predicting their magnitude and area of impact. This mainly concerns uncertainties in the dam break process, involved volumes, erosion rates, changing rheologies, and the limited capabilities of available software packages to simulate process interactions and transformations such as the development of a hyperconcentrated flow into a debris flow. In addition, many areas prone to lake outburst floods are located in developing countries with a limited scope of the threatened population for decision-making and limited resources for mitigation.

Competition from below for light and nutrients shifts productivity among tropical species

Treesearch

J. J. Ewel; M. J. Mazzarino

2008-01-01

Chance events such as seed dispersal determine the potential composition of plant communities, but the eventual assemblage is determined in large part by subsequent interactions among species. Postcolonization sorting also affects the ultimate composition of communities assembled by people for restoration, horticulture, or conservation. Thus,...

Quantifying Discrete Fracture Network Connectivity in Hydraulic Fracturing Stimulation

NASA Astrophysics Data System (ADS)

Urbancic, T.; Ardakani, E. P.; Baig, A.

2017-12-01

Hydraulic fracture stimulations generally result in microseismicity that is associated with the activation or extension of pre-existing microfractures and discontinuities. Microseismic events acquired under 3D downhole sensor coverage provide accurate event locations outlining hydraulic fracture growth. Combined with source characteristics, these events provide a high quality input for seismic moment tensor inversion and eventually constructing the representative discrete fracture network (DFN). In this study, we investigate the strain and stress state, identified fracture orientation, and DFN connectivity and performance for example stages in a multistage perf and plug completion in a North American shale play. We use topology, the familiar concept in many areas of structural geology, to further describe the relationships between the activated fractures and their effectiveness in enhancing permeability. We explore how local perturbations of stress state lead to the activation of different fractures sets and how that effects the DFN interaction and complexity. In particular, we observe that a more heterogeneous stress state shows a higher percentage of sub-horizontal fractures or bedding plane slips. Based on topology, the fractures are evenly distributed from the injection point, with decreasing numbers of connections by distance. The dimensionless measure of connection per branch and connection per line are used for quantifying the DFN connectivity. In order to connect the concept of connectivity back to productive volume and stimulation efficiency, the connectivity is compared with the character of deformation in the reservoir as deduced from the collective behavior of microseismicity using robustly determined source parameters.

Very large release of mostly volcanic carbon during the Palaeocene-Eocene Thermal Maximum

NASA Astrophysics Data System (ADS)

Gutjahr, Marcus; Ridgwell, Andy; Sexton, Philip F.; Anagnostou, Eleni; Pearson, Paul N.; Pälike, Heiko; Norris, Richard D.; Thomas, Ellen; Foster, Gavin L.

2017-08-01

The Palaeocene-Eocene Thermal Maximum (PETM) was a global warming event that occurred about 56 million years ago, and is commonly thought to have been driven primarily by the destabilization of carbon from surface sedimentary reservoirs such as methane hydrates. However, it remains controversial whether such reservoirs were indeed the source of the carbon that drove the warming. Resolving this issue is key to understanding the proximal cause of the warming, and to quantifying the roles of triggers versus feedbacks. Here we present boron isotope data—a proxy for seawater pH—that show that the ocean surface pH was persistently low during the PETM. We combine our pH data with a paired carbon isotope record in an Earth system model in order to reconstruct the unfolding carbon-cycle dynamics during the event. We find strong evidence for a much larger (more than 10,000 petagrams)—and, on average, isotopically heavier—carbon source than considered previously. This leads us to identify volcanism associated with the North Atlantic Igneous Province, rather than carbon from a surface reservoir, as the main driver of the PETM. This finding implies that climate-driven amplification of organic carbon feedbacks probably played only a minor part in driving the event. However, we find that enhanced burial of organic matter seems to have been important in eventually sequestering the released carbon and accelerating the recovery of the Earth system.

Microseismicity of an Unstable Rock Mass: From Field Monitoring to Laboratory Testing

NASA Astrophysics Data System (ADS)

Colombero, C.; Comina, C.; Vinciguerra, S.; Benson, P. M.

2018-02-01

The field-scale microseismic (MS) activity of an unstable rock mass is known to be an important tool to assess damage and cracking processes eventually leading to macroscopic failures. However, MS-event rates alone may not be enough for a complete understanding of the trigger mechanisms of mechanical instabilities. Acoustic Emission (AE) techniques at the laboratory scale can be used to provide complementary information. In this study, we report a MS/AE comparison to assess the stability of a granitic rock mass in the northwestern Italian Alps (Madonna del Sasso). An attempt to bridge the gap between the two different scales of observation, and the different site and laboratory conditions, is undertaken to gain insights on the rock mass behavior as a function of external governing factors. Time- and frequency-domain parameters of the MS/AE waveforms are compared and discussed with this aim. At the field scale, special attention is devoted to the correlation of the MS-event rate with meteorological parameters (air temperature and rainfalls). At the laboratory scale, AE rates, waveforms, and spectral content, recorded under controlled temperature and fluid conditions, are analyzed in order to better constrain the physical mechanisms responsible for the observed field patterns. The factors potentially governing the mechanical instability at the site were retrieved from the integration of the results. Abrupt thermal variations were identified as the main cause of the site microsesimicity, without highlighting irreversible acceleration in the MS-event rate potentially anticipating the rock mass collapse.

SAGE 2D and 3D Simulations of the Explosive Venting of Supercritical Fluids Through Porous Media

NASA Astrophysics Data System (ADS)

Weaver, R.; Gisler, G.; Svensen, H.; Mazzini, A.

2008-12-01

Magmatic intrusive events in large igneous provinces heat sedimentary country rock leading to the eventual release of volatiles. This has been proposed as a contributor to climate change and other environmental impacts. By means of numerical simulations, we examine ways in which these volatiles can be released explosively from depth. Gases and fluids cooked out of country rock by metamorphic heating may be confined for a time by impermeable clays or other barriers, developing high pressures and supercritical fluids. If confinement is suddenly breached (by an earthquake for example) in such a way that the fluid has access to porous sediments, a violent eruption of a non-magmatic mixture of fluid and sediment may result. Surface manifestations of these events could be hydrothermal vent complexes, kimberlite pipes, pockmarks, or mud volcanoes. These are widespread on Earth, especially in large igneous provinces, as in the Karoo Basin of South Africa, the North Sea off the Norwegian margin, and the Siberian Traps. We have performed 2D and 3D simulations with the Sage hydrocode (from Los Alamos and Science Applications International) of supercritical venting in a variety of geometries and configurations. The simulations show several different patterns of propagation and fracturing in porous or otherwise weakened overburden, dependent on depth, source conditions (fluid availability, temperature, and pressure), and manner of confinement breach. Results will be given for a variety of 2D and 3D simulations of these events exploring the release of volatiles into the atmosphere.

A Wireless Intracranial Brain Deformation Sensing System for Blast-Induced Traumatic Brain Injury

PubMed Central

Song, S.; Race, N. S.; Kim, A.; Zhang, T.; Shi, R.; Ziaie, B.

2015-01-01

Blast-induced traumatic brain injury (bTBI) has been linked to a multitude of delayed-onset neurodegenerative and neuropsychiatric disorders, but complete understanding of their pathogenesis remains elusive. To develop mechanistic relationships between bTBI and post-blast neurological sequelae, it is imperative to characterize the initiating traumatic mechanical events leading to eventual alterations of cell, tissue, and organ structure and function. This paper presents a wireless sensing system capable of monitoring the intracranial brain deformation in real-time during the event of a bTBI. The system consists of an implantable soft magnet and an external head-mounted magnetic sensor that is able to measure the field in three dimensions. The change in the relative position of the soft magnet WITH respect to the external sensor as the result of the blast wave induces changes in the magnetic field. The magnetic field data in turn is used to extract the temporal and spatial motion of the brain under the blast wave in real-time. The system has temporal and spatial resolutions of 5 μs and 10 μm. Following the characterization and validation of the sensor system, we measured brain deformations in a live rodent during a bTBI. PMID:26586273

Comparison of emergency department crowding scores: a discrete-event simulation approach.

PubMed

Ahalt, Virginia; Argon, Nilay Tanık; Ziya, Serhan; Strickler, Jeff; Mehrotra, Abhi

2018-03-01

According to American College of Emergency Physicians, emergency department (ED) crowding occurs when the identified need for emergency services exceeds available resources for patient care in the ED, hospital, or both. ED crowding is a widely reported problem and several crowding scores are proposed to quantify crowding using hospital and patient data as inputs for assisting healthcare professionals in anticipating imminent crowding problems. Using data from a large academic hospital in North Carolina, we evaluate three crowding scores, namely, EDWIN, NEDOCS, and READI by assessing strengths and weaknesses of each score, particularly their predictive power. We perform these evaluations by first building a discrete-event simulation model of the ED, validating the results of the simulation model against observations at the ED under consideration, and utilizing the model results to investigate each of the three ED crowding scores under normal operating conditions and under two simulated outbreak scenarios in the ED. We conclude that, for this hospital, both EDWIN and NEDOCS prove to be helpful measures of current ED crowdedness, and both scores demonstrate the ability to anticipate impending crowdedness. Utilizing both EDWIN and NEDOCS scores in combination with the threshold values proposed in this work could provide a real-time alert for clinicians to anticipate impending crowding, which could lead to better preparation and eventually better patient care outcomes.

Real-Time Analysis of Magnetic Hyperthermia Experiments on Living Cells under a Confocal Microscope.

PubMed

Connord, Vincent; Clerc, Pascal; Hallali, Nicolas; El Hajj Diab, Darine; Fourmy, Daniel; Gigoux, Véronique; Carrey, Julian

2015-05-01

Combining high-frequency alternating magnetic fields (AMF) and magnetic nanoparticles (MNPs) is an efficient way to induce biological responses through several approaches: magnetic hyperthermia, drug release, controls of gene expression and neurons, or activation of chemical reactions. So far, these experiments cannot be analyzed in real-time during the AMF application. A miniaturized electromagnet fitting under a confocal microscope is built, which produces an AMF of frequency and amplitude similar to the ones used in magnetic hyperthermia. AMF application induces massive damages to tumoral cells having incorporated nanoparticles into their lysosomes without affecting the others. Using this setup, real-time analyses of molecular events occurring during AMF application are performed. Lysosome membrane permeabilization and reactive oxygen species production are detected after only 30 min of AMF application, demonstrating they occur at an early stage in the cascade of events leading eventually to cell death. Additionally, lysosomes self-assembling into needle-shaped organization under the influence of AMF is observed in real-time. This experimental approach will permit to get a deeper insight into the physical, molecular, and biological process occurring in several innovative techniques used in nanomedecine based on the combined use of MNPs and high-frequency magnetic fields. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Dome-like behaviour at Mt. Etna: The case of the 28 December 2014 South East Crater paroxysm.

PubMed

Ferlito, C; Bruno, V; Salerno, G; Caltabiano, T; Scandura, D; Mattia, M; Coltorti, M

2017-07-13

On the 28 December 2014, a violent and short paroxysmal eruption occurred at the South East Crater (SEC) of Mount Etna that led to the formation of huge niches on the SW and NE flanks of the SEC edifice from which a volume of ~3 × 10 6  m 3 of lava was erupted. Two basaltic lava flows discharged at a rate of ~370 m 3 /s, reaching a maximum distance of ~5 km. The seismicity during the event was scarce and the eruption was not preceded by any notable ground deformation, which instead was dramatic during and immediately after the event. The SO 2 flux associated with the eruption was relatively low and even decreased few days before. Observations suggest that the paroxysm was not related to the ascent of volatile-rich fresh magma from a deep reservoir (dyke intrusion), but instead to a collapse of a portion of SEC, similar to what happens on exogenous andesitic domes. The sudden and fast discharge eventually triggered a depressurization in the shallow volcano plumbing system that drew up fresh magma from depth. Integration of data and observations has allowed to formulate a novel interpretation of mechanism leading volcanic activity at Mt. Etna and on basaltic volcanoes worldwide.

Optimal infrastructure maintenance scheduling problem under budget uncertainty.

DOT National Transportation Integrated Search

2010-05-01

This research addresses a general class of infrastructure asset management problems. Infrastructure : agencies usually face budget uncertainties that will eventually lead to suboptimal planning if : maintenance decisions are made without taking the u...

Fingernails Yield Clues to Limb Regeneration

MedlinePlus

... in mice. The findings, published in the journal Nature, could eventually lead to the development of novel ... Nail Epithelium Couples Nail Growth to Digit Regeneration. Nature 2013 Jul 11;499(7457):228-32. doi: ...

Can the Solid State Greenhouse Effect Produce ~100 Year Cycles in the Mars South Polar Residual CO2 Ice Cap?

NASA Astrophysics Data System (ADS)

Line, M. R.; Ingersoll, A. P.

2010-12-01

Malin et al. (2001) reported that the south perennial cap consists of quasi-circular pits ~8 meters deep, with a flat surface in between. The walls of the pits are retreating at a rate of 1 to 3 meters per year. Byrne and Ingersoll (2003a, 2003b) showed evidence that the floors of the pits are water ice and the upper layer is CO2. This layer will be gone in a few Martian centuries, if the observations are taken at face value. This raises some difficult questions: How likely is it that mankind would be witnessing the final few hundred years of the residual CO2 frost on Mars? Can one imagine extreme weather events that could recharge the residual CO2 frost once it is gone? Both seem unlikely, and we propose a different mechanism. Kieffer et al. (2000) showed that sunlight can penetrate several meters through the seasonal CO2 frost, where it warms the surface below. We have observational evidence that the same is happening in the perennial CO2 frost. Further, we have a model that shows how this "solid-state greenhouse" can lead to cyclic behavior, in which layers of CO2 build up on a water ice substrate, are heated internally by sunlight and lose mass from within. Eventually the layer becomes too weak to support itself, and it collapses to form pits. Then a new CO2 layer accumulates and the process repeats. Our study addresses fundamental questions of long-term stability of the Martian polar caps and how the caps control the atmospheric pressure. Instead of invoking extreme climate events to explain the data, we propose that processes within the frost itself can lead to cyclic growth and collapse of the pits. Our model implies that there is no long-term change in the ~8 meter layer of CO2 and no extreme weather events to make it change.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ibarra, Luis; Sanders, David; Yang, Haori

The main goal of this study is to evaluate the long-term seismic performance of freestanding and anchored Dry Storage Casks (DSCs) using experimental tests on a shaking table, as well as comprehensive numerical evaluations that include the cask-pad-soil system. The study focuses on the dynamic performance of vertical DSCs, which can be designed as free-standing structures resting on a reinforced concrete foundation pad, or casks anchored to a foundation pad. The spent nuclear fuel (SNF) at nuclear power plants (NPPs) is initially stored in fuel-storage pools to control the fuel temperature. After several years, the fuel assemblies are transferred tomore » DSCs at sites contiguous to the plant, known as Interim Spent Fuel Storage Installations (ISFSIs). The regulations for these storage systems (10 CFR 72) ensure adequate passive heat removal and radiation shielding during normal operations, off-normal events, and accident scenarios. The integrity of the DSCs is important, even if the overpack does not breach, because eventually the spent fuel-rods need to be shipped either to a reprocessing plant or a repository. DSCs have been considered as a temporary storage solution, and usually are licensed for 20 years, although they can be relicensed for operating periods of up to 60 years. In recent years, DSCs have been reevaluated as a potential mid-term solution, in which the operating period may be extended for up to 300 years. At the same time, recent seismic events have underlined the significant risks DSCs are exposed. The consideration of DCSs for storing spent fuel for hundreds of years has created new challenges. In the case of seismic hazard, longer-term operating periods not only lead to larger horizontal accelerations, but also increase the relative effect of vertical accelerations that usually are disregarded for smaller seismic events. These larger seismic demands could lead to casks sliding and tipping over, impacting the concrete pad or adjacent casks. The casks may also slide and collide with other casks or structural components. Also, the different DSC components may impact each other during these events. This study provides a comprehensive evaluation of DSCs subjected to these extreme demands, including the effect of vertical accelerations, and soilstructure interaction.« less

Redox signaling in acute pancreatitis

PubMed Central

Pérez, Salvador; Pereda, Javier; Sabater, Luis; Sastre, Juan

2015-01-01

Acute pancreatitis is an inflammatory process of the pancreatic gland that eventually may lead to a severe systemic inflammatory response. A key event in pancreatic damage is the intracellular activation of NF-κB and zymogens, involving also calcium, cathepsins, pH disorders, autophagy, and cell death, particularly necrosis. This review focuses on the new role of redox signaling in acute pancreatitis. Oxidative stress and redox status are involved in the onset of acute pancreatitis and also in the development of the systemic inflammatory response, being glutathione depletion, xanthine oxidase activation, and thiol oxidation in proteins critical features of the disease in the pancreas. On the other hand, the release of extracellular hemoglobin into the circulation from the ascitic fluid in severe necrotizing pancreatitis enhances lipid peroxidation in plasma and the inflammatory infiltrate into the lung and up-regulates the HIF–VEGF pathway, contributing to the systemic inflammatory response. Therefore, redox signaling and oxidative stress contribute to the local and systemic inflammatory response during acute pancreatitis. PMID:25778551

Mosaic Graphs and Comparative Genomics in Phage Communities

PubMed Central

Belcaid, Mahdi; Bergeron, Anne

2010-01-01

Abstract Comparing the genomes of two closely related viruses often produces mosaics where nearly identical sequences alternate with sequences that are unique to each genome. When several closely related genomes are compared, the unique sequences are likely to be shared with third genomes, leading to virus mosaic communities. Here we present comparative analysis of sets of Staphylococcus aureus phages that share large identical sequences with up to three other genomes, and with different partners along their genomes. We introduce mosaic graphs to represent these complex recombination events, and use them to illustrate the breath and depth of sequence sharing: some genomes are almost completely made up of shared sequences, while genomes that share very large identical sequences can adopt alternate functional modules. Mosaic graphs also allow us to identify breakpoints that could eventually be used for the construction of recombination networks. These findings have several implications on phage metagenomics assembly, on the horizontal gene transfer paradigm, and more generally on the understanding of the composition and evolutionary dynamics of virus communities. PMID:20874413

Activation of the hypothalamic-pituitary-adrenal axis by addictive drugs: different pathways, common outcome.

PubMed

Armario, Antonio

2010-07-01

Addictive drugs (opiates, ethanol, cannabinoids (CBs), nicotine, cocaine, amphetamines) induce activation of the hypothalamic-pituitary-adrenal (HPA) axis, with the subsequent release of adrenocorticotropic hormone and glucocorticoids. The sequence of events leading to HPA activation appears to start within the brain, suggesting that activation is not secondary to peripheral homeostatic alterations. The precise neurochemical mechanisms and brain pathways involved are markedly dependent on the particular drug, although it is assumed that information eventually converges into the hypothalamic paraventricular nucleus (PVN). Whereas some drugs may act on the hypothalamus or directly within PVN neurons (i.e. ethanol), others exert their primary action outside the PVN (i.e. CBs, nicotine, cocaine). Corticotropin-releasing hormone (CRH) has a critical role in most cases, but the changes in c-fos and CRH gene expression in the PVN also reveal differences among drugs. More studies are needed to understand how addictive drugs act on this important neuroendocrine system and their functional consequences. Copyright 2010 Elsevier Ltd. All rights reserved.

Systemic lupus erythematosus presenting with Kikuchi-Fujimoto's disease as a long-term sequela of drug-induced hypersensitivity syndrome. A possible role of Epstein-Barr virus reactivation.

PubMed

Aota, N; Hirahara, K; Kano, Y; Fukuoka, T; Yamada, A; Shiohara, T

2009-01-01

Drug-induced hypersensitivity syndrome (DIHS) is a severe form of drug eruptions associated with viral reactivations. Autoimmune diseases have been reported to develop several months or years after the resolution of DIHS. We describe a 36-year-old man with cervical lymphadenopathy and an erythematous eruption affecting the face and neck, which evolved into clinically evident systemic lupus erythematosus. He had had an episode of DIHS 4 years previously, in which human herpesvirus-6 and Epstein-Barr virus (EBV) were reactivated. Expression of EBV-encoded RNA was detected in the lymph node. On the basis of findings in this patient, we suggest that EBV is pathogenically important in the sequence of events leading to the onset of systemic lupus erythematosus and that patients with a history of DIHS may be at a risk of eventually developing autoimmune diseases. 2008 S. Karger AG, Basel

Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2.

PubMed

Mendez-Bermudez, Aaron; Lototska, Liudmyla; Bauwens, Serge; Giraud-Panis, Marie-Josèphe; Croce, Olivier; Jamet, Karine; Irizar, Agurtzane; Mowinckel, Macarena; Koundrioukoff, Stephane; Nottet, Nicolas; Almouzni, Genevieve; Teulade-Fichou, Mare-Paule; Schertzer, Michael; Perderiset, Mylène; Londoño-Vallejo, Arturo; Debatisse, Michelle; Gilson, Eric; Ye, Jing

2018-05-03

Hard-to-replicate regions of chromosomes (e.g., pericentromeres, centromeres, and telomeres) impede replication fork progression, eventually leading, in the event of replication stress, to chromosome fragility, aging, and cancer. Our knowledge of the mechanisms controlling the stability of these regions is essentially limited to telomeres, where fragility is counteracted by the shelterin proteins. Here we show that the shelterin subunit TRF2 ensures progression of the replication fork through pericentromeric heterochromatin, but not centromeric chromatin. In a process involving its N-terminal basic domain, TRF2 binds to pericentromeric Satellite III sequences during S phase, allowing the recruitment of the G-quadruplex-resolving helicase RTEL1 to facilitate fork progression. We also show that TRF2 is required for the stability of other heterochromatic regions localized throughout the genome, paving the way for future research on heterochromatic replication and its relationship with aging and cancer. Copyright © 2018 Elsevier Inc. All rights reserved.

Ice damage to concrete

DOT National Transportation Integrated Search

1998-04-01

Concrete is a porous material. When saturated with water and then cooled to below 00C, it cracks internally. Upon repeated freezing and thawing, the cracks grow, interact, and lead eventually to macroscopic degradation, termed ice damage. This report...

Bridge deck resurfacing using Rosphalt 50.

DOT National Transportation Integrated Search

2006-10-01

Most bridge decks in Maine are comprised of Reinforced Portland Cement Concrete (RPCC). Although a : durable product, RPCC is permeable and susceptible to chloride penetration leading to corrosion of the : steel reinforcement and eventual cracking of...

Is Hyperinsulinemia a Form of Diabetes?

MedlinePlus

... underlying problem. Hyperinsulinemia is most often caused by insulin resistance — a condition in which your body doesn't ... pancreas tries to compensate by making more insulin. Insulin resistance may eventually lead to the development of type ...

Aryl Trifluoromethyl Iximes: potential new mosquito insecticides

USDA-ARS?s Scientific Manuscript database

Fluorinated methylketones have been identified as potential mosquitocides, suspected of acting as reaction coordinate analogues that inhibit acetylcholinesterase (AChE) thereby leading to paralysis and eventual death. Previous work has explored trifluoro-, difluoro-, and fluoromethylketone analogues...

Impact of Channel-like Erosion Patterns on the Frequency-Magnitude Distribution of Earthquakes

NASA Astrophysics Data System (ADS)

Rohmer, J.; Aochi, H.

2015-12-01

Reactive flow at depth (either related to underground activities like enhancement of hydrocarbon recovery, CO2 storage or to natural flow like in hydrothermal zones) can alter fractures' topography, which might in turn change their seismic responses. Depending on the flow and reaction rates, instability of the dissolution front can lead to a wormhole-like pronounced erosion pattern (Szymczak & Ladd, JGR, 2009). In a fractal structure of rupture process (Ide & Aochi, JGR, 2005), we question how the perturbation related to well-spaced long channels alters rupture propagation initiated on a weak plane and eventually the statistical feature of rupture appearance in Frequency-Magnitude Distribution FMD (Rohmer & Aochi, GJI, 2015). Contrary to intuition, a spatially uniform dissolution is not the most remarkable case, since it affects all the events proportionally to their sizes leading to a downwards translation of FMD: the slope of FMD (b-value) remains unchanged. An in-depth parametric study was carried out by considering different pattern characteristics: spacing S varying from 0 to 100 and length L from 50 to 800 and fixing the width w=1. The figure shows that there is a region of optimum channels' characteristics for which the b-value of the Gutenberg Richter law is significantly modified with p-value ~10% (corresponding to area with red-coloured boundaries) given spacing to length ratio of the order of ~1/40: large magnitude events are more significantly affected leading to an imbalanced distribution in the magnitude bins of the FMD. The larger the spacing, the lower the channel's influence. The decrease of the b-value between intact and altered fractures can reach values down to -0.08. Besides, a spatial analysis shows that the local seismicity anomaly concentrates in a limited zone around the channels: this opens perspective for detecting these eroded regions through high-resolution imaging surveys.

Discovering Geography: Teacher Created Activities for High School and Middle School.

ERIC Educational Resources Information Center

Petersen, James F., Ed.

This guide contains 20 classroom activities designed by teachers to study topics in geography with the eventual goal of aiding in the development of geographic literacy in students. The various activities involve map reading skills, climatology, current events, urban development, and community planning. Each activity presentation includes an event…

Protect-your-prostate message delivered on Parliament Hill

PubMed Central

Gray, C

1998-01-01

In March Charlotte Gray attended a luncheon on Parliament Hill where a message on prostate cancer was served along with the meatballs. Thirty MPs attended the event, and organizer Ted White hopes the prevention message delivered by Dr. Martin Gleave will eventually trickle down to politicians in other levels of government. PMID:9614828

Implementing Meeting Agendas into a Health Management Course

ERIC Educational Resources Information Center

VanderMolen, Julia

2017-01-01

Purpose: The purpose of this article is to share methods of teaching health education management students on the importance of time management and learn how to conduct a meeting within a health education management course and eventually in a professional setting. Methods: The assignments used in the course are current-event relevant and…

An operational hydrological ensemble prediction system for the city of Zurich (Switzerland): skill, case studies and scenarios

NASA Astrophysics Data System (ADS)

Addor, N.; Jaun, S.; Fundel, F.; Zappa, M.

2011-07-01

The Sihl River flows through Zurich, Switzerland's most populated city, for which it represents the largest flood threat. To anticipate extreme discharge events and provide decision support in case of flood risk, a hydrometeorological ensemble prediction system (HEPS) was launched operationally in 2008. This model chain relies on limited-area atmospheric forecasts provided by the deterministic model COSMO-7 and the probabilistic model COSMO-LEPS. These atmospheric forecasts are used to force a semi-distributed hydrological model (PREVAH), coupled to a hydraulic model (FLORIS). The resulting hydrological forecasts are eventually communicated to the stakeholders involved in the Sihl discharge management. This fully operational setting provides a real framework with which to compare the potential of deterministic and probabilistic discharge forecasts for flood mitigation. To study the suitability of HEPS for small-scale basins and to quantify the added-value conveyed by the probability information, a reforecast was made for the period June 2007 to December 2009 for the Sihl catchment (336 km2). Several metrics support the conclusion that the performance gain can be of up to 2 days lead time for the catchment considered. Brier skill scores show that overall COSMO-LEPS-based hydrological forecasts outperforms their COSMO-7-based counterparts for all the lead times and event intensities considered. The small size of the Sihl catchment does not prevent skillful discharge forecasts, but makes them particularly dependent on correct precipitation forecasts, as shown by comparisons with a reference run driven by observed meteorological parameters. Our evaluation stresses that the capacity of the model to provide confident and reliable mid-term probability forecasts for high discharges is limited. The two most intense events of the study period are investigated utilising a novel graphical representation of probability forecasts, and are used to generate high discharge scenarios. They highlight challenges for making decisions on the basis of hydrological predictions, and indicate the need for a tool to be used in addition to forecasts to compare the different mitigation actions possible in the Sihl catchment. No definitive conclusion on the model chain capacity to forecast flooding events endangering the city of Zurich could be drawn because of the under-sampling of extreme events. Further research on the form of the reforecasts needed to infer on floods associated to return periods of several decades, centuries, is encouraged.

Tobacco smoking.

PubMed

Charles, Janice; Valenti, Lisa; Britt, Helena

2014-06-01

Worldwide, 22% of adults aged ≥15 years currently smoke tobacco. Up to half of current smokers will eventually die of a tobacco-related disease, and smoking is the leading cause of ill health, drug-related death and hospital separations in Australia.

Putting a New Filter On Cancer Screening.

PubMed

Huff, Charlotte

2016-10-01

Experts are rethinking routine cancer screening. Genetic tests could be the answer. They may add upfront expense, but might eventually lead to savings by winnowing out unnecessary screening. Concern about false positives helps push this movement along.

Genetics Home Reference: congenital nephrotic syndrome

MedlinePlus

... eventually leading to end-stage renal disease. NPHS1 gene mutations cause all cases of congenital nephrotic syndrome of ... is found in people of Finnish ancestry. NPHS1 gene mutations can cause congenital nephrotic syndrome in non-Finnish ...

Bridge deck resurfacing using Rosphalt 50 : construction report.

DOT National Transportation Integrated Search

2003-01-01

Most bridge decks in Maine are comprised of Reinforced Portland Cement Concrete (RPCC). Although a : durable product, RPCC is permeable and susceptible to chloride penetration leading to corrosion of the : steel reinforcement and eventual cracking of...

On Corporate Accountability: Lead, Asbestos, and Fossil Fuel Lawsuits.

PubMed

Shearer, Christine

2015-08-01

This paper examines the use of lawsuits against three industries that were eventually found to be selling products damaging to human heath and the environment: lead paint, asbestos, and fossil fuels. These industries are similar in that some companies tried to hide or distort information showing their products were harmful. Common law claims were eventually filed to hold the corporations accountable and compensate the injured. This paper considers the important role the lawsuits played in helping establish some accountability for the industries while also noting the limitations of the lawsuits. It will be argued that the lawsuits helped create pressure for government regulation of the industries' products but were less successful at securing compensation for the injured. Thus, the common law claims strengthened and supported administrative regulation and the adoption of industry alternatives more than they provided a means of legal redress. © The Author(s) 2015.

Event Display for the Visualization of CMS Events

NASA Astrophysics Data System (ADS)

Bauerdick, L. A. T.; Eulisse, G.; Jones, C. D.; Kovalskyi, D.; McCauley, T.; Mrak Tadel, A.; Muelmenstaedt, J.; Osborne, I.; Tadel, M.; Tu, Y.; Yagil, A.

2011-12-01

During the last year the CMS experiment engaged in consolidation of its existing event display programs. The core of the new system is based on the Fireworks event display program which was by-design directly integrated with the CMS Event Data Model (EDM) and the light version of the software framework (FWLite). The Event Visualization Environment (EVE) of the ROOT framework is used to manage a consistent set of 3D and 2D views, selection, user-feedback and user-interaction with the graphics windows; several EVE components were developed by CMS in collaboration with the ROOT project. In event display operation simple plugins are registered into the system to perform conversion from EDM collections into their visual representations which are then managed by the application. Full event navigation and filtering as well as collection-level filtering is supported. The same data-extraction principle can also be applied when Fireworks will eventually operate as a service within the full software framework.

Do local meteorological conditions influence skin irritation caused by transdermal rivastigmine? A retroprospective, pilot study.

PubMed

Segers, Kurt; Cytryn, Ephraim; Surquin, Murielle

2012-06-01

This retrospective study aimed to evaluate the incidence of transdermal rivastigmine treatment withdrawal secondary to adverse skin reactions among the patients from our Memory Clinic. In addition, we tested whether climatic conditions might have an influence on skin irritations leading to eventual treatment disruption. We performed a retrospective review of patients from the Brugmann University Hospital Memory Clinic having started transdermal rivastigmine between June 2008 and December 2010. Local meteorological data were provided by the Royal Meteorological Institute of Belgium. A total of 26.9% of the patients experienced adverse skin reactions at the rivastigmine application site, leading to treatment discontinuation in 19.2% of the cases. Rivastigmine cutaneous tolerability was not found to be related to demographic parameters, Mini Mental Status Examination score, or type of dementia. High temperature and low air humidity during the first month of treatment were found to be associated with a higher incidence of skin reactions and secondary treatment disruption. Transdermal rivastigmine induced a higher incidence of cutaneous adverse events than previously reported in a prospective clinical trial. Moreover, it seems that meteorological conditions favoring skin perspiration (high temperature and low air humidity) during the first month of treatment might have an influence on transdermal rivastigmine skin tolerability.

Plant Insecticidal Toxins in Ecological Networks

PubMed Central

Ibanez, Sébastien; Gallet, Christiane; Després, Laurence

2012-01-01

Plant secondary metabolites play a key role in plant-insect interactions, whether constitutive or induced, C- or N-based. Anti-herbivore defences against insects can act as repellents, deterrents, growth inhibitors or cause direct mortality. In turn, insects have evolved a variety of strategies to act against plant toxins, e.g., avoidance, excretion, sequestration and degradation of the toxin, eventually leading to a co-evolutionary arms race between insects and plants and to co-diversification. Anti-herbivore defences also negatively impact mutualistic partners, possibly leading to an ecological cost of toxin production. However, in other cases toxins can also be used by plants involved in mutualistic interactions to exclude inadequate partners and to modify the cost/benefit ratio of mutualism to their advantage. When considering the whole community, toxins have an effect at many trophic levels. Aposematic insects sequester toxins to defend themselves against predators. Depending on the ecological context, toxins can either increase insects’ vulnerability to parasitoids and entomopathogens or protect them, eventually leading to self-medication. We conclude that studying the community-level impacts of plant toxins can provide new insights into the synthesis between community and evolutionary ecology. PMID:22606374

An operational hydrological ensemble prediction system for the city of Zurich (Switzerland): assessing the added value of probabilistic forecasts

NASA Astrophysics Data System (ADS)

Addor, N.; Jaun, S.; Fundel, F.; Zappa, M.

2012-04-01

The Sihl River flows through Zurich, Switzerland's most populated city, for which it represents the largest flood threat. To anticipate extreme discharge events and provide decision support in case of flood risk, a hydrometeorological ensemble prediction system (HEPS) was launched operationally in 2008. This model chain relies on deterministic (COSMO-7) and probabilistic (COSMO-LEPS) atmospheric forecasts, which are used to force a semi-distributed hydrological model (PREVAH) coupled to a hydraulic model (FLORIS). The resulting hydrological forecasts are eventually communicated to the stakeholders involved in the Sihl discharge management. This fully operational setting provides a real framework with which we assessed the potential of deterministic and probabilistic discharge forecasts for flood mitigation. To study the suitability of HEPS for small-scale basins and to quantify the added value conveyed by the probability information, a 31-month reforecast was produced for the Sihl catchment (336 km2). Several metrics support the conclusion that the performance gain is of up to 2 days lead time for the catchment considered. Brier skill scores show that probabilistic hydrological forecasts outperform their deterministic counterparts for all the lead times and event intensities considered. The small size of the Sihl catchment does not prevent skillful discharge forecasts, but makes them particularly dependent on correct precipitation forecasts. Our evaluation stresses that the capacity of the model to provide confident and reliable mid-term probability forecasts for high discharges is limited. We finally highlight challenges for making decisions on the basis of hydrological predictions, and discuss the need for a tool to be used in addition to forecasts to compare the different mitigation actions possible in the Sihl catchment.

A viscoplastic shear-zone model for deep (15-50 km) slow-slip events at plate convergent margins

NASA Astrophysics Data System (ADS)

Yin, An; Xie, Zhoumin; Meng, Lingsen

2018-06-01

A key issue in understanding the physics of deep (15-50 km) slow-slip events (D-SSE) at plate convergent margins is how their initially unstable motion becomes stabilized. Here we address this issue by quantifying a rate-strengthening mechanism using a viscoplastic shear-zone model inspired by recent advances in field observations and laboratory experiments. The well-established segmentation of slip modes in the downdip direction of a subduction shear zone allows discretization of an interseismic forearc system into the (1) frontal segment bounded by an interseismically locked megathrust, (2) middle segment bounded by episodically locked and unlocked viscoplastic shear zone, and (3) interior segment that slips freely. The three segments are assumed to be linked laterally by two springs that tighten with time, and the increasing elastic stress due to spring tightening eventually leads to plastic failure and initial viscous shear. This simplification leads to seven key model parameters that dictate a wide range of mechanical behaviors of an idealized convergent margin. Specifically, the viscoplastic rheology requires the initially unstable sliding to be terminated nearly instantaneously at a characteristic velocity, which is followed by stable sliding (i.e., slow-slip). The characteristic velocity, which is on the order of <10-7 m/s for the convergent margins examined in this study, depends on the (1) effective coefficient of friction, (2) thickness, (3) depth, and (4) viscosity of the viscoplastic shear zone. As viscosity decreases exponentially with temperature, our model predicts faster slow-slip rates, shorter slow-slip durations, more frequent slow-slip occurrences, and larger slow-slip magnitudes at warmer convergent margins.

Percutaneous tricuspid valvotomy for pacemaker lead-induced tricuspid stenosis

PubMed Central

Patil, Devendra V.; Nabar, Ashish A.; Sabnis, Girish R.; Phadke, Milind S.; Lanjewar, Charan P.; Kerkar, Prafulla G.

2015-01-01

Permanent pacemaker lead-induced tricuspid regurgitation is extremely uncommon. We report a patient with severe tricuspid stenosis detected 10 years after permanent single chamber pacemaker implantation in surgically corrected congenital heart disease. The loop at the level of the tricuspid valve may have caused endothelial injury and eventually led to stenosis. Percutaneous balloon valvotomy for such stenosis has not been reported from India. PMID:26995417

Long-term persistence of spent lead shot in tundra wetlands

USGS Publications Warehouse

Flint, Paul L.; Schamber, Jason L.

2010-01-01

We seeded experimental plots with number 4 lead pellets and sampled these plots for 10 years to assess the settlement rate of pellets in tundra wetland types commonly used by foraging waterfowl. After 10 years, about 10% of pellets remained within 6 cm of the surface, but >50% remained within 10 cm. We predict that spent lead pellets will eventually become unavailable to waterfowl; however, it will likely require >25 years for all pellets to exceed depths at which waterfowl species may forage.

Analysis of arrhythmic events is useful to detect lead failure earlier in patients followed by remote monitoring.

PubMed

Nishii, Nobuhiro; Miyoshi, Akihito; Kubo, Motoki; Miyamoto, Masakazu; Morimoto, Yoshimasa; Kawada, Satoshi; Nakagawa, Koji; Watanabe, Atsuyuki; Nakamura, Kazufumi; Morita, Hiroshi; Ito, Hiroshi

2018-03-01

Remote monitoring (RM) has been advocated as the new standard of care for patients with cardiovascular implantable electronic devices (CIEDs). RM has allowed the early detection of adverse clinical events, such as arrhythmia, lead failure, and battery depletion. However, lead failure was often identified only by arrhythmic events, but not impedance abnormalities. To compare the usefulness of arrhythmic events with conventional impedance abnormalities for identifying lead failure in CIED patients followed by RM. CIED patients in 12 hospitals have been followed by the RM center in Okayama University Hospital. All transmitted data have been analyzed and summarized. From April 2009 to March 2016, 1,873 patients have been followed by the RM center. During the mean follow-up period of 775 days, 42 lead failure events (atrial lead 22, right ventricular pacemaker lead 5, implantable cardioverter defibrillator [ICD] lead 15) were detected. The proportion of lead failures detected only by arrhythmic events, which were not detected by conventional impedance abnormalities, was significantly higher than that detected by impedance abnormalities (arrhythmic event 76.2%, 95% CI: 60.5-87.9%; impedance abnormalities 23.8%, 95% CI: 12.1-39.5%). Twenty-seven events (64.7%) were detected without any alert. Of 15 patients with ICD lead failure, none has experienced inappropriate therapy. RM can detect lead failure earlier, before clinical adverse events. However, CIEDs often diagnose lead failure as just arrhythmic events without any warning. Thus, to detect lead failure earlier, careful human analysis of arrhythmic events is useful. © 2017 Wiley Periodicals, Inc.

Dynamics of nitrate and chloride during storm events in agricultural catchments with different subsurface drainage intensity (Indiana, USA)

USDA-ARS?s Scientific Manuscript database

Grids of perforated pipe buried beneath many poorly drained agricultural fields in the Midwestern U.S. are believed to “short circuit” pools of nitrate-laden soil water and shallow groundwater directly into streams that eventually discharge to the Mississippi River. Although much is known about the ...

Iranian EFL Teachers' Voices on the Pedagogy of Word and World

ERIC Educational Resources Information Center

Safari, Parvin; Rashidi, Nasser

2015-01-01

Critical pedagogy (CP) with the eventual aim of creating changes in society towards the socially just world rests upon the premise that language learning is understood as a sociopolitical event. Schools and classrooms are not merely seen as the neutral and apolitical sites or oxymoron of transmitting taken-for-granted knowledge and common sense to…

Shadowed by War: Building Community Capacity to Support Military Families

ERIC Educational Resources Information Center

Huebner, Angela J.; Mancini, Jay A.; Bowen, Gary L.; Orthner, Dennis K.

2009-01-01

The context of military service has changed greatly since the events of 9/11. The forward deployment of service members to active war zones, which involves the issues of separation, time away from home, and eventual reunion, increases the vulnerability of their families to multiple, negative short-term and long-term effects. This article explores…

Nonlinear attenuation of S-waves and Love waves within ambient rock

NASA Astrophysics Data System (ADS)

Sleep, Norman H.; Erickson, Brittany A.

2014-04-01

obtain scaling relationships for nonlinear attenuation of S-waves and Love waves within sedimentary basins to assist numerical modeling. These relationships constrain the past peak ground velocity (PGV) of strong 3-4 s Love waves from San Andreas events within Greater Los Angeles, as well as the maximum PGV of future waves that can propagate without strong nonlinear attenuation. During each event, the shaking episode cracks the stiff, shallow rock. Over multiple events, this repeated damage in the upper few hundred meters leads to self-organization of the shear modulus. Dynamic strain is PGV divided by phase velocity, and dynamic stress is strain times the shear modulus. The frictional yield stress is proportional to depth times the effective coefficient of friction. At the eventual quasi-steady self-organized state, the shear modulus increases linearly with depth allowing inference of past typical PGV where rock over the damaged depth range barely reaches frictional failure. Still greater future PGV would cause frictional failure throughout the damaged zone, nonlinearly attenuating the wave. Assuming self-organization has taken place, estimated maximum past PGV within Greater Los Angeles Basins is 0.4-2.6 m s-1. The upper part of this range includes regions of accumulating sediments with low S-wave velocity that may have not yet compacted, rather than having been damaged by strong shaking. Published numerical models indicate that strong Love waves from the San Andreas Fault pass through Whittier Narrows. Within this corridor, deep drawdown of the water table from its currently shallow and preindustrial levels would nearly double PGV of Love waves reaching Downtown Los Angeles.

Prospective Coding by Spiking Neurons

PubMed Central

Brea, Johanni; Gaál, Alexisz Tamás; Senn, Walter

2016-01-01

Animals learn to make predictions, such as associating the sound of a bell with upcoming feeding or predicting a movement that a motor command is eliciting. How predictions are realized on the neuronal level and what plasticity rule underlies their learning is not well understood. Here we propose a biologically plausible synaptic plasticity rule to learn predictions on a single neuron level on a timescale of seconds. The learning rule allows a spiking two-compartment neuron to match its current firing rate to its own expected future discounted firing rate. For instance, if an originally neutral event is repeatedly followed by an event that elevates the firing rate of a neuron, the originally neutral event will eventually also elevate the neuron’s firing rate. The plasticity rule is a form of spike timing dependent plasticity in which a presynaptic spike followed by a postsynaptic spike leads to potentiation. Even if the plasticity window has a width of 20 milliseconds, associations on the time scale of seconds can be learned. We illustrate prospective coding with three examples: learning to predict a time varying input, learning to predict the next stimulus in a delayed paired-associate task and learning with a recurrent network to reproduce a temporally compressed version of a sequence. We discuss the potential role of the learning mechanism in classical trace conditioning. In the special case that the signal to be predicted encodes reward, the neuron learns to predict the discounted future reward and learning is closely related to the temporal difference learning algorithm TD(λ). PMID:27341100

An experimental overview of the seismic cycle

NASA Astrophysics Data System (ADS)

Spagnuolo, E.; Violay, M.; Passelegue, F. X.; Nielsen, S. B.; Di Toro, G.

2017-12-01

Earthquake nucleation is the last stage of the inter-seismic cycle where the fault surface evolves through the interplay of friction, healing, stress perturbations and strain events. Slip stability under rate-and state friction has been extensively discussed in terms of loading point velocity and equivalent fault stiffness, but fault evolution towards seismic runaway under complex loading histories (e.g. slow variations of tectonic stress, stress transfer from impulsive nearby seismic events) is not yet fully investigated. Nevertheless, the short term earthquake forecasting is based precisely on a relation between seismic productivity and loading history which remains up to date still largely unresolved. To this end we propose a novel experimental approach which avails of a closed loop control of the shear stress, a nominally infinite equivalent slip and transducers for continuous monitoring of acoustic emissions. This experimental simulation allows us to study the stress dependency and temporal evolution of spontaneous slip events occurring on a pre-existing fault subjected to different loading histories. The experimental fault has an initial roughness which mimic a population of randomly distributed asperities, which here are used as a proxy for patches which are either far or close to failure on an extended fault. Our observations suggest that the increase of shear stress may trigger either spontaneous slow slip (creep) or short-lived stick-slip bursts, eventually leading to a fast slip instability (seismic runaway) when slip rates are larger than a few cm/s. The event type and the slip rate are regulated at first order by the background shear stress whereas the ultimate strength of the entire fault is dominated by the number of asperities close to failure under a stress step. The extrapolation of these results to natural conditions might explain the plethora of events that often characterize seismic sequences. Nonetheless this experimental approach helps the definition of a scaling relation between the loading rate and cumulated slip which is relevant to the definition of a recurrence model for the seismic cycle.

Genetics Home Reference: blepharophimosis, ptosis, and epicanthus inversus syndrome

MedlinePlus

... features. Type I is also associated with an early loss of ovarian function (primary ovarian insufficiency) in women, which causes their menstrual periods to become less frequent and eventually stop before age 40. Primary ovarian insufficiency can lead to difficulty ...

Batten's Disease: Determining Educational Interventions.

ERIC Educational Resources Information Center

Johnson, Barbara; Jochum, Julie

1996-01-01

This article presents basic information on the causes, physical and emotional characteristics, diagnosis and treatment, and educational implications of Batten's Disease, a degenerative neurological disorder which strikes children and adults, causes progressive loss of neurological function, and leads to eventual premature death. Discussion also…

Yoga as a Burnout Preventative for Psychology Graduate Students

ERIC Educational Resources Information Center

Marquez, Genevive

2011-01-01

Psychology graduate students experience unique stressors resulting from academic tasks and regular exposure to emotional distress (Stratton, Kellaway, & Rottini, 2007). Pervasive stress may eventually lead to burnout: emotional exhaustion, depersonalization, and reduced personal accomplishment (Maslach, 1986). Burnout impinges on academic…

Tellurium: providing a bright future for solar energy

USGS Publications Warehouse

Goldfarb, Richard J.

2015-01-01

Because of its low abundance, little is known about environmental baseline concentrations for tellurium or its toxic effect on humans and ecosystems. Human exposure to tellurium can lead to a garlic odor on the breath, nausea, and eventual respiratory problems.

Grower price effects of Innate™ potato

USDA-ARS?s Scientific Manuscript database

The revival of biotechnology applications for potato raises interesting economic questions that we examine here. Technologies of this sort increase supply by decreasing waste and reducing percentage of off-grade product. Increased supply leads, eventually, to reductions in the market price, so that ...

Bridge deck resurfacing using Rosphalt 50 : interim report - first year, December 2004.

DOT National Transportation Integrated Search

2004-12-01

Most bridge decks in Maine are comprised of Reinforced Portland Cement Concrete (RPCC). Although a : durable product, RPCC is permeable and susceptible to chloride penetration leading to corrosion of the : steel reinforcement and eventual cracking of...

Infection of Retained Defibrillator Lead Fragment after Heart Transplant

PubMed Central

Durante-Mangoni, Emanuele; Vitrone, Martina; Mattucci, Irene; Caprioli, Vincenzo; Maiello, Ciro

2017-01-01

A 59-year old heart transplant recipient was admitted due to continuous pain in her left axilla. A purulent collection was found at the site of prior defibrillator placement, where a remnant proximal segment of an electric lead was found. Two years before, the patient had had pocket infection treated with revision, but without device extraction. The remnant lead was eventually removed transvenously without complications. This is the first description of infection complicating retention of lead fragments after heart transplant. The role of biofilm and net immune state on the persistence and late recurrence of infection is discussed. PMID:28458812

Temporal Genetic Modifications after Controlled Cortical Impact—Understanding Traumatic Brain Injury through a Systematic Network Approach

PubMed Central

Wong, Yung-Hao; Wu, Chia-Chou; Wu, John Chung-Che; Lai, Hsien-Yong; Chen, Kai-Yun; Jheng, Bo-Ren; Chen, Mien-Cheng; Chang, Tzu-Hao; Chen, Bor-Sen

2016-01-01

Traumatic brain injury (TBI) is a primary injury caused by external physical force and also a secondary injury caused by biological processes such as metabolic, cellular, and other molecular events that eventually lead to brain cell death, tissue and nerve damage, and atrophy. It is a common disease process (as opposed to an event) that causes disabilities and high death rates. In order to treat all the repercussions of this injury, treatment becomes increasingly complex and difficult throughout the evolution of a TBI. Using high-throughput microarray data, we developed a systems biology approach to explore potential molecular mechanisms at four time points post-TBI (4, 8, 24, and 72 h), using a controlled cortical impact (CCI) model. We identified 27, 50, 48, and 59 significant proteins as network biomarkers at these four time points, respectively. We present their network structures to illustrate the protein–protein interactions (PPIs). We also identified UBC (Ubiquitin C), SUMO1, CDKN1A (cyclindependent kinase inhibitor 1A), and MYC as the core network biomarkers at the four time points, respectively. Using the functional analytical tool MetaCore™, we explored regulatory mechanisms and biological processes and conducted a statistical analysis of the four networks. The analytical results support some recent findings regarding TBI and provide additional guidance and directions for future research. PMID:26861311

Does pressure cause liver cirrhosis? The sinusoidal pressure hypothesis.

PubMed

Mueller, Sebastian

2016-12-28

Independent of their etiology, all chronic liver diseases ultimately lead to liver cirrhosis, which is a major health problem worldwide. The underlying molecular mechanisms are still poorly understood and no efficient treatment strategies are available. This paper introduces the sinusoidal pressure hypothesis (SPH), which identifies an elevated sinusoidal pressure (SP) as cause of fibrosis. SPH has been mainly derived from recent studies on liver stiffness. So far, pressure changes have been exclusively seen as a consequence of cirrhosis. According to the SPH, however, an elevated SP is the major upstream event that initiates fibrosis via biomechanic signaling by stretching of perisinusoidal cells such as hepatic stellate cells or fibroblasts (SPH part I: initiation). Fibrosis progression is determined by the degree and time of elevated SP. The SPH predicts that the degree of extracellular matrix eventually matches SP with critical thresholds > 12 mmHg and > 4 wk. Elevated arterial flow and final arterialization of the cirrhotic liver represents the self-perpetuating key event exposing the low-pressure-organ to pathologically high pressures (SPH part II: perpetuation). It also defines the "point of no return" where fibrosis progression becomes irreversible. The SPH is able to explain the macroscopic changes of cirrhotic livers and the uniform fibrotic response to various etiologies. It also opens up new views on the role of fat and disease mechanisms in other organs. The novel concept will hopefully stimulate the search for new treatment strategies.

Formation of Magnetic Flux Ropes during a Confined Flaring Well before the Onset of a Pair of Major Coronal Mass Ejections

NASA Astrophysics Data System (ADS)

Chintzoglou, Georgios; Patsourakos, Spiros; Vourlidas, Angelos

2015-08-01

NOAA active region (AR) 11429 was the source of twin super-fast coronal mass ejections (CMEs). The CMEs took place within an hour from each other, with the onset of the first taking place in the beginning of 2012 March 7. This AR fulfills all the requirements for a “super active region” namely, Hale's law incompatibility and a δ-spot magnetic configuration. One of the biggest storms of Solar Cycle 24 to date ({D}{st}=-143 nT) was associated with one of these events. Magnetic flux ropes (MFRs) are twisted magnetic structures in the corona, best seen in ˜10 MK hot plasma emission and are often considered the core of erupting structures. However, their “dormant” existence in the solar atmosphere (i.e., prior to eruptions), is an open question. Aided by multi-wavelength observations by the Solar Dynamics Observatory (SDO) and by the Solar Terrestrial Relations Observatory (STEREO) and a nonlinear force-free model for the coronal magnetic field, our work uncovers two separate, weakly twisted magnetic flux systems which suggest the existence of pre-eruption MFRs that eventually became the seeds of the two CMEs. The MFRs could have been formed during confined (i.e., not leading to major CMEs) flaring and sub-flaring events which took place the day before the two CMEs in the host AR 11429.

Renal amyloidosis: current views on pathogenesis and impact on diagnosis.

PubMed

Herrera, Guillermo A; Teng, Jiamin; Turbat-Herrera, Elba A

2011-01-01

The amyloidoses constitute a group of diseases in which misfolding of extracellular proteins plays a fundamental role. The aggregation of normally soluble proteins into insoluble unbranching fibrils is the basic underlying pathology in amyloidosis. The process of amyloid formation generates toxic insoluble (in saline) protein aggregates that are deposited in tissues in the form of β- pleated sheets of fibrillary material. The amyloidoses are considered to be part of the so-called protein storage diseases (protein thesauroses). In addition, due to the unusual protein folding associated with amyloid, this group of diseases has been referred to as conformational and protein folding disorders. For many years amyloidosis was considered an extremely rare, somewhat mysterious disease. However, in recent years its pathogenesis, particularly that of renal amyloidosis, has been carefully dissected in the research laboratory using in vitro and, to a lesser extent, in vivo models. These have provided a molecular understanding of sequential events that take place in the renal mesangium leading to the formation of amyloid fibrils and eventual extrusion into the mesangial matrix, which itself becomes seriously damaged and, in due time, replaced by the fibrillary material. Amyloid, once considered to be an 'inert' substance, has been proven to be involved in crucial biological processes that result in the destruction and eventual replacement of normal renal constituents. Although there are more than two dozen recognized amyloid precursor proteins (and new ones being added to the list) that can be involved in the genesis of amyloid fibrils, the pathophysiologic mechanisms that occur in the renal mesangium are likely to be very similar, if not the same, regardless of the type of amyloidosis. Likewise, the same is true of amyloid formation in the renal vasculature. Mesangial cells are essentially smooth muscle cells and the events that take place in the mesangium and vasculature (where smooth muscle cells and/or pericytes are present) in the entire body responsible for the formation of amyloid are the same. In the renal interstitium, fibroblasts likely participate in the formation of amyloid, following a similar sequence of events as smooth muscle cells. Although much of the information gathered has been from in vitro systems, an in vivo model of renal amyloidosis has recently been designed to study renal amyloidogenesis. Crucial steps in the cascade of events that result in the formation of amyloid fibrils have been elucidated in the laboratory. The information that has been gathered regarding the pathogenesis of amyloidosis has been translated to the clinical arena where implementation of new therapeutic approaches is beginning to occur. Additional molecular-based therapies will be implemented in the near future. Copyright © 2011 S. Karger AG, Basel.

Entropy Production of Emerging Turbulent Scales in a Temporal Supercritical N-Neptane/Nitrogen Three-Dimensional Mixing Layer

NASA Technical Reports Server (NTRS)

Bellan, J.; Okongo, N.

2000-01-01

A study of emerging turbulent scales entropy production is conducted for a supercritical shear layer as a precursor to the eventual modeling of Subgrid Scales (from a turbulent state) leading to Large Eddy Simulations.

20 CFR 633.102 - Scope and purpose of title IV, section 402 programs.

Code of Federal Regulations, 2010 CFR

2010-04-01

... substantially aggravated by continual advancements in technology and mechanization resulting in displacement and... eventual placement in unsubsidized agricultural or nonagricultural employment; (3) Allow activities leading to stabilization in agricultural employment; and (4) Include related assistance and supportive...

Formal analysis of imprecise system requirements with Event-B.

PubMed

Le, Hong Anh; Nakajima, Shin; Truong, Ninh Thuan

2016-01-01

Formal analysis of functional properties of system requirements needs precise descriptions. However, the stakeholders sometimes describe the system with ambiguous, vague or fuzzy terms, hence formal frameworks for modeling and verifying such requirements are desirable. The Fuzzy If-Then rules have been used for imprecise requirements representation, but verifying their functional properties still needs new methods. In this paper, we propose a refinement-based modeling approach for specification and verification of such requirements. First, we introduce a representation of imprecise requirements in the set theory. Then we make use of Event-B refinement providing a set of translation rules from Fuzzy If-Then rules to Event-B notations. After that, we show how to verify both safety and eventuality properties with RODIN/Event-B. Finally, we illustrate the proposed method on the example of Crane Controller.

Subliminal (latent) processing of pain and its evolution to conscious awareness

PubMed Central

Borsook, David; Youssef, Andrew M.; Barakat, Nadia; Sieberg, Christine B.; Elman, Igor

2018-01-01

By unconscious or covert processing of pain we refer to nascent interactions that affect the eventual deliverance of pain awareness. Thus, internal processes (viz., repeated nociceptive events, inflammatory kindling, re-organization of brain networks, genetic) or external processes (viz., environment, socioeconomic levels, modulation of epigenetic status) contribute to enhancing or inhibiting the presentation of pain awareness. Here we put forward the notion that for many patients, ongoing sub-conscious changes in brain function are significant players in the eventual manifestation of chronic pain. In this review, we provide clinical examples of nascent or what we term pre-pain processes and the neurobiological mechanisms of how these changes may contribute to pain, but also potential opportunities to define the process for early therapeutic interventions. PMID:29476771

Subliminal (latent) processing of pain and its evolution to conscious awareness.

PubMed

Borsook, David; Youssef, Andrew M; Barakat, Nadia; Sieberg, Christine B; Elman, Igor

2018-05-01

By unconscious or covert processing of pain we refer to nascent interactions that affect the eventual deliverance of pain awareness. Thus, internal processes (viz., repeated nociceptive events, inflammatory kindling, reorganization of brain networks, genetic) or external processes (viz., environment, socioeconomic levels, modulation of epigenetic status) contribute to enhancing or inhibiting the presentation of pain awareness. Here we put forward the notion that for many patients, ongoing sub-conscious changes in brain function are significant players in the eventual manifestation of chronic pain. In this review, we provide clinical examples of nascent or what we term pre-pain processes and the neurobiological mechanisms of how these changes may contribute to pain, but also potential opportunities to define the process for early therapeutic interventions. Copyright © 2018. Published by Elsevier Ltd.

Analysis of causes of the eventual increment in climatic episodies in the period 2004-2014 and the consequences on the coast of Galicia (NW Spain)

NASA Astrophysics Data System (ADS)

Rodriguez Lopez, Fernando; Diez, Javier; Veiga, Efren

2015-04-01

In recent years has observed an increase in atmospheric and marine events on the coast of Galicia (Spain) which have caused economic losses and human lives; and also an alarm in the population. This work analyse the consequences in order temporal and geographical; and the possible causes and influences which can motivate the presence of these events and their consequences. This work also proposes a strategy to prevent such events and to limit their effects. The generating criteria proposed is a rating system of security, in such way that the society by itself generates the trends for improvement. Keywords: Security, Civil engineering, Marine constructions, Realibility, Insurance, Prevention forensic engineering

Quantitative Authorship Attribution of Users of Mexican Drug Dealing Related Online Forums

ERIC Educational Resources Information Center

Rico Sulayes, Antonio

2012-01-01

As the violence in the Mexican drug war escalates, a proliferation of social media sites about drug trafficking in Mexico was followed by the murder of some of their users, and the eventual disappearance of many of those sites. Despite these events, there still exist a number of drug-dealing related social media outlets in this country with a…

The Effects of False Physiological Feedback on Sexual Arousal in Sexually Dysfunctional and Functional Males

DTIC Science & Technology

1999-01-01

might increase their arousal or lead to orgasm , such as direct clitoral 10 stimulation . Poor sexual skills might also lead to frequent sexual failure and... orgasm . However, cessation of stimulation during the plateau or excitement phases results in eventual return to pre- stimulation levels. The orgasmic ...access to the physical and psychological stimulation that would normally produce heightened sexual arousal and "spontaneous" erection. This interference

Electricity storage: Friend or foe of the networks?

NASA Astrophysics Data System (ADS)

Jamasb, Tooraj

2017-06-01

As storage technology progresses it offers a range of solutions and services to users and the electricity industry. A new study explores whether or not this will eventually lead to self-sufficient consumers and spell the end of the networks as we know them.

Inspection and evaluation of a bridge deck reinforced with carbon fiber reinforced polymer (CFRP) bars.

DOT National Transportation Integrated Search

2006-03-01

Cracking in reinforced concrete decks is inevitable. It leads to the corrosion and eventual deterioration of the deck system. The use of non-corrosive reinforcement is one alternative to steel in reinforced concrete construction. : This report deals ...

CALS Baseline Architecture Analysis of Weapons System. Technical Information: Army, Draft. Volume 8

DOT National Transportation Integrated Search

1989-09-01

This effort was performed to provide a common framework for analysis and planning of CALS initiatives across the military services, leading eventually to the development of a common DoD-wide architecture for CALS. This study addresses Army technical ...

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, Stephanie Stilson, NASA vehicle manager for Discovery, stands in front of a leading edge on the wing of Discovery. She is being filmed for a special feature on the KSC Web about the recent Orbiter Major Modification period on Discovery, which included inspection, modifications and reservicing of most systems onboard, plus installation of a Multifunction Electronic Display Subsystem (MEDS) - a state-of-the-art “glass cockpit.” The orbiter is now being prepared for eventual launch on a future mission.

NASA Image and Video Library

2004-01-22

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, Stephanie Stilson, NASA vehicle manager for Discovery, stands in front of a leading edge on the wing of Discovery. She is being filmed for a special feature on the KSC Web about the recent Orbiter Major Modification period on Discovery, which included inspection, modifications and reservicing of most systems onboard, plus installation of a Multifunction Electronic Display Subsystem (MEDS) - a state-of-the-art “glass cockpit.” The orbiter is now being prepared for eventual launch on a future mission.

Air cushioning in drop impact

NASA Astrophysics Data System (ADS)

de Ruiter, Jolet; Oh, Jung; van den Ende, Dirk; Mugele, Frieder

2011-11-01

Liquid drops impacting on solid surfaces deform under the influence of the ambient gas that needs to be squeezed out before a true solid-liquid contact can be established. We demonstrate experimentally the existence of this theoretically predicted air layer and follow its evolution with time for moderate impact speeds (We ~ 1 ... 10) using reflection interference microscopy with a thickness resolution of approximately 10nm. For a wide range of fluid properties (ρ, γ, η) we find a very robust generic behavior that includes the predicted formation of a dimple in the center of the drop with a local minimum of the air film thickness at its boundary. Depending on We as well as the fluid properties, a skating layer of more or less constant thickness as well as a second local minimum of the air film thickness farther away from the drop center develop in time. Eventually, solid-liquid contact is generated via random nucleation event. The nucleation spot spreads across the drop-substrate interface within a few milliseconds. This process can lead to the entrapment of an air bubble.

Adverse events, toxicity and post-mortem data on duloxetine: case reports and literature survey.

PubMed

Vey, Eric L; Kovelman, Inna

2010-05-01

Duloxetine, a dual acting norepinephrine serotonin reuptake inhibitor, is a relatively new pharmacologic agent utilized in the treatment of depression, as well as diabetic neuropathic pain, fibromyalgia, and female stress urinary incontinence. This expanding scope of usage will inevitably lead to its eventual appearance during routine post-mortem toxicologic assays. Currently there is a paucity of post-mortem toxicologic data concerning duloxetine. The current report provides six additional case reports of post-mortem duloxetine levels, along with a review of duloxetine's pharmacokinetics, and the toxicologic manifestations which have been reported in the literature. The post-mortem levels reported, including the highest level recorded to date, are integrated with previously published reports to generate a foundation for a nascent guide to the interpretation of post-mortem duloxetine levels that could be encountered during routine post-mortem toxicologic analyses, and establish a basis upon which the establishment of toxic and lethal thresholds for this compound can be further elucidated with greater clarity. Copyright (c) 2010 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

Type I interferon enhances necroptosis of Salmonella Typhimurium–infected macrophages by impairing antioxidative stress responses

PubMed Central

Hos, Nina Judith; Hos, Deniz; Klimek, Jennifer; Abdullah, Zeinab; Krönke, Martin

2017-01-01

Salmonella enterica serovar Typhimurium exploits the host’s type I interferon (IFN-I) response to induce receptor-interacting protein (RIP) kinase–mediated necroptosis in macrophages. However, the events that drive necroptosis execution downstream of IFN-I and RIP signaling remain elusive. In this study, we demonstrate that S. Typhimurium infection causes IFN-I–mediated up-regulation of the mitochondrial phosphatase Pgam5 through RIP3. Pgam5 subsequently interacts with Nrf2, which sequesters Nrf2 in the cytosol, thereby repressing the transcription of Nrf2-dependent antioxidative genes. The impaired ability to respond to S. Typhimurium–induced oxidative stress results in reactive oxygen species–mediated mitochondrial damage, energy depletion, transient induction of autophagy, and autophagic degradation of p62. Reduced p62 levels impair interaction of p62 with Keap1, which further decreases Nrf2 function and antioxidative responses to S. Typhimurium infection, eventually leading to cell death. Collectively, we identify impaired Nrf2-dependent redox homeostasis as an important mechanism that promotes cell death downstream of IFN-I and RIP3 signaling in S. Typhimurium–infected macrophages. PMID:29055012

Global warming of the mantle at the origin of flood basalts over supercontinents

NASA Astrophysics Data System (ADS)

Coltice, N.; Phillips, B. R.; Bertrand, H.; Ricard, Y.; Rey, P.

2007-05-01

Continents episodically cluster together into a supercontinent, eventually breaking up with intense magmatic activity supposedly caused by mantle plumes (Morgan, 1983; Richards et al., 1989; Condie, 2004). The breakup of Pangea, the last supercontinent, was accompanied by the emplacement of the largest known continental flood basalt, the Central Atlantic Magmatic Province, which caused massive extinctions at the Triassic-Jurassic boundary (Marzoli et al., 1999). However, there is little support for a plume origin for this catastrophic event (McHone, 2000). On the basis of convection modeling in an internally heated mantle, this paper shows that continental aggregation promotes large-scale melting without requiring the involvement of plumes. When only internal heat sources in the mantle are considered, the formation of a supercontinent causes the enlargement of flow wavelength and a subcontinental increase in temperature as large as 100 °C. This temperature increase may lead to large-scale melting without the involvement of plumes. Our results suggest the existence of two distinct types of continental flood basalts, caused by plume or by mantle global warming.

Acoustic emission of fire damaged fiber reinforced concrete

NASA Astrophysics Data System (ADS)

Mpalaskas, A. C.; Matikas, T. E.; Aggelis, D. G.

2016-04-01

The mechanical behavior of a fiber-reinforced concrete after extensive thermal damage is studied in this paper. Undulated steel fibers have been used for reinforcement. After being exposed to direct fire action at the temperature of 850°C, specimens were subjected to bending and compression in order to determine the loss of strength and stiffness in comparison to intact specimens and between the two types. The fire damage was assessed using nondestructive evaluation techniques, specifically ultrasonic pulse velocity (UPV) and acoustic emission (AE). Apart from the strong, well known, correlation of UPV to strength (both bending and compressive), AE parameters based mainly on the frequency and duration of the emitted signals after cracking events showed a similar or, in certain cases, better correlation with the mechanical parameters and temperature. This demonstrates the sensitivity of AE to the fracture incidents which eventually lead to failure of the material and it is encouraging for potential in-situ use of the technique, where it could provide indices with additional characterization capability concerning the mechanical performance of concrete after it subjected to fire.

Variability Studies of Two Prunus-Infecting Fabaviruses with the Aid of High-Throughput Sequencing

PubMed Central

Sarkisova, Tatiana; Lenz, Ondřej; Přibylová, Jaroslava; Špak, Josef; Lotos, Leonidas; Beta, Christina; Katsiani, Asimina; Candresse, Thierry

2018-01-01

During their lifetime, perennial woody plants are expected to face multiple infection events. Furthermore, multiple genotypes of individual virus species may co-infect the same host. This may eventually lead to a situation where plants harbor complex communities of viral species/strains. Using high-throughput sequencing, we describe co-infection of sweet and sour cherry trees with diverse genomic variants of two closely related viruses, namely prunus virus F (PrVF) and cherry virus F (CVF). Both viruses are most homologous to members of the Fabavirus genus (Secoviridae family). The comparison of CVF and PrVF RNA2 genomic sequences suggests that the two viruses may significantly differ in their expression strategy. Indeed, similar to comoviruses, the smaller genomic segment of PrVF, RNA2, may be translated in two collinear proteins while CVF likely expresses only the shorter of these two proteins. Linked with the observation that identity levels between the coat proteins of these two viruses are significantly below the family species demarcation cut-off, these findings support the idea that CVF and PrVF represent two separate Fabavirus species. PMID:29670059

Etiopathology of chronic tubular, glomerular and renovascular nephropathies: Clinical implications

PubMed Central

2011-01-01

Chronic kidney disease (CKD) comprises a group of pathologies in which the renal excretory function is chronically compromised. Most, but not all, forms of CKD are progressive and irreversible, pathological syndromes that start silently (i.e. no functional alterations are evident), continue through renal dysfunction and ends up in renal failure. At this point, kidney transplant or dialysis (renal replacement therapy, RRT) becomes necessary to prevent death derived from the inability of the kidneys to cleanse the blood and achieve hydroelectrolytic balance. Worldwide, nearly 1.5 million people need RRT, and the incidence of CKD has increased significantly over the last decades. Diabetes and hypertension are among the leading causes of end stage renal disease, although autoimmunity, renal atherosclerosis, certain infections, drugs and toxins, obstruction of the urinary tract, genetic alterations, and other insults may initiate the disease by damaging the glomerular, tubular, vascular or interstitial compartments of the kidneys. In all cases, CKD eventually compromises all these structures and gives rise to a similar phenotype regardless of etiology. This review describes with an integrative approach the pathophysiological process of tubulointerstitial, glomerular and renovascular diseases, and makes emphasis on the key cellular and molecular events involved. It further analyses the key mechanisms leading to a merging phenotype and pathophysiological scenario as etiologically distinct diseases progress. Finally clinical implications and future experimental and therapeutic perspectives are discussed. PMID:21251296

Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria.

PubMed

Xiao, Mengqing; Zhong, Huiqin; Xia, Lin; Tao, Yongzhen; Yin, Huiyong

2017-10-01

Mitochondrial lipids are essential for maintaining the integrity of mitochondrial membranes and the proper functions of mitochondria. As the "powerhouse" of a cell, mitochondria are also the major cellular source of reactive oxygen species (ROS). Oxidative stress occurs when the antioxidant system is overwhelmed by overproduction of ROS. Polyunsaturated fatty acids in mitochondrial membranes are primary targets for ROS attack, which may lead to lipid peroxidation (LPO) and generation of reactive lipids, such as 4-hydroxynonenal. When mitochondrial lipids are oxidized, the integrity and function of mitochondria may be compromised and this may eventually lead to mitochondrial dysfunction, which has been associated with many human diseases including cancer, cardiovascular diseases, diabetes, and neurodegenerative diseases. How mitochondrial lipids are oxidized and the underlying molecular mechanisms and pathophysiological consequences associated with mitochondrial LPO remain poorly defined. Oxidation of the mitochondria-specific phospholipid cardiolipin and generation of bioactive lipids through mitochondrial LPO has been increasingly recognized as an important event orchestrating apoptosis, metabolic reprogramming of energy production, mitophagy, and immune responses. In this review, we focus on the current understanding of how mitochondrial LPO and generation of bioactive lipid mediators in mitochondria are involved in the modulation of mitochondrial functions in the context of relevant human diseases associated with oxidative stress. Copyright © 2017 Elsevier Inc. All rights reserved.

Atmospheric Pressure Room Temperature Plasma Jets Facilitate Oxidative and Nitrative Stress and Lead to Endoplasmic Reticulum Stress Dependent Apoptosis in HepG2 Cells

PubMed Central

Meng, Dandan; Lei, Qian; Li, Yin; Deng, Pengyi; Chen, Mingjie; Tu, Min; Lu, Xinpei; Yang, Guangxiao; He, Guangyuan

2013-01-01

Atmospheric pressure room temperature plasma jets (APRTP-Js) that can emit a mixture of different active species have recently found entry in various medical applications. Apoptosis is a key event in APRTP-Js-induced cellular toxicity, but the exact biological mechanisms underlying remain elusive. Here, we explored the role of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in APRTP-Js-induced apoptosis using in vitro model of HepG2 cells. We found that APRTP-Js facilitated the accumulation of ROS and RNS in cells, which resulted in the compromised cellular antioxidant defense system, as evidenced by the inactivation of cellular antioxidants including glutathione (GSH), superoxide dismutase (SOD) and catalase. Nitrotyrosine and protein carbonyl content analysis indicated that APRTP-Js treatment caused nitrative and oxidative injury of cells. Meanwhile, intracellular calcium homeostasis was disturbed along with the alteration in the expressions of GRP78, CHOP and pro-caspase12. These effects accumulated and eventually culminated into the cellular dysfunction and endoplasmic reticulum stress (ER stress)-mediated apoptosis. The apoptosis could be markedly attenuated by N-acetylcysteine (NAC, a free radical scavenger), which confirmed the involvement of oxidative and nitrative stress in the process leading to HepG2 cell apoptosis by APRTP-Js treatment. PMID:24013954

Pathophysiology of NASH: perspectives for a targeted treatment

PubMed Central

Marra, Fabio; Lotersztajn, Sophie

2013-01-01

Non alcoholic steatohepatitis (NASH) is the more severe form of nonalcoholic fatty liver disease. In NASH, fatty liver, hepatic inflammation, hepatocyte injury and fibrogenesis are associated, and thi condition may eventually lead to cirrhosis. Current treatment of NASH relies on the reduction of body weight and increase in physical activity, but there is no pharmacologic treatment approved as yet. Emerging data indicate that NASH progression results from parallel events originating from the liver as well as from the adipose tissue, the gut and the gastrointestinal tract. Thus, dysfunction of the adipose tissue through enhanced flow of free fatty acids and release of adipocytokines, and alterations in the gut microbiome generate proinflammatory signals that underly NASH progression. Additional ‘extrahepatic hits’ include dietary factors and gastrointestinal hormones. Within the liver, hepatocyte apoptosis, ER stress and oxidative stress are key contributors to hepatocellular injury. In addition, lipotoxic mediators and danger signals activate Kupffer cells which initiate and perpetuate the inflammatory response by releasing inflammatory mediators that contribute to inflammatory cell recruitment and development of fibrosis. Inflammatory and fibrogenic mediators include chemokines, the cannabinoid system, the inflammasome and activation of pattern-recognition receptors. Here we review the major mechanisms leading to appearance and progression of NASH, focusing on both extrahepatic signals and local inflammatory mechanisms, in an effort to identify the most promising molecular targets for the treatment of this condition. PMID:23394092

A Freshwater Starvation Mechanism for Dansgaard-Oeschger Cycles

NASA Astrophysics Data System (ADS)

Wolff, E. W.; Hewitt, I.; Fowler, A.; Clark, C.; Evatt, G. W.; Munday, D. R.; Stokes, C.

2014-12-01

Many northern hemisphere climate records, particularly those from around the North Atlantic, show a series of rapid climate changes that recurred on centennial to millennial timescales throughout most of the last glacial period. These Dansgaard-Oeschger (D-O) sequences are observed most prominently in Greenland ice cores, although they have a global signature, including an out of phase Antarctic signal. They consist of warming jumps of order 10°C, occurring in typically 40 years, followed generally by a slow cooling (Greenland Interstadial, GI) lasting between a few centuries and a few millennia, and then a final rapid temperature drop into a cold Greenland Stadial (GS) that lasts for a similar period. The most distinctive feature of D-O cycles is the rapid warming event, often attributed to a sudden change in the strength of the Atlantic meridional overturning circulation (AMOC). Recent work has suggested that AMOC is most easily disrupted by freshwater delivered through the Arctic. We suggest that the proposed AMOC changes may have occurred as part of a natural oscillation, in which runoff from the Laurentide ice sheet into the Arctic is controlled by temperature around the North Atlantic. The Arctic buffers the salinity changes, but under warm conditions, high runoff eventually leads to water entering the North Atlantic with low enough salinity to switch AMOC into its weaker state. Under the colder conditions now prevailing, the Arctic is starved of runoff, and the salinity rises until a further switch occurs. Contrary to many previous studies, this mechanism does not require large freshwater pulses to the North Atlantic. Instead, steady changes in ice-sheet runoff, driven by the AMOC, lead to a naturally arising oscillator, in which the rapid warmings come about because the Arctic Ocean is starved of freshwater. The changing size of the ice sheets would have affected the magnitude and extent of runoff, and we suggest that this may provide a simple explanation for the absence of the events during interglacials and around the time of glacial maxima. Heinrich events, delivering additional freshwater into the Atlantic during a Greenland stadial, play no direct role in this mechanism, but would serve to delay the switch to faster AMOC.

An operational hydrological ensemble prediction system for the city of Zurich (Switzerland): skill, case studies and scenarios

NASA Astrophysics Data System (ADS)

Addor, N.; Jaun, S.; Zappa, M.

2011-01-01

The Sihl River flows through Zurich, Switzerland's most populated city, for which it represents the largest flood threat. To anticipate extreme discharge events and provide decision support in case of flood risk, a hydrometeorological ensemble prediction system (HEPS) was launched operationally in 2008. This models chain relies on limited-area atmospheric forecasts provided by the deterministic model COSMO-7 and the probabilistic model COSMO-LEPS. These atmospheric forecasts are used to force a semi-distributed hydrological model (PREVAH), coupled to a hydraulic model (FLORIS). The resulting hydrological forecasts are eventually communicated to the stakeholders involved in the Sihl discharge management. This fully operational setting provides a real framework to compare the potential of deterministic and probabilistic discharge forecasts for flood mitigation. To study the suitability of HEPS for small-scale basins and to quantify the added-value conveyed by the probability information, a reforecast was made for the period June 2007 to December 2009 for the Sihl catchment (336 km2). Several metrics support the conclusion that the performance gain can be of up to 2 days lead time for the catchment considered. Brier skill scores show that COSMO-LEPS-based hydrological forecasts overall outperform their COSMO-7 based counterparts for all the lead times and event intensities considered. The small size of the Sihl catchment does not prevent skillful discharge forecasts, but makes them particularly dependent on correct precipitation forecasts, as shown by comparisons with a reference run driven by observed meteorological parameters. Our evaluation stresses that the capacity of the model to provide confident and reliable mid-term probability forecasts for high discharges is limited. The two most intense events of the study period are investigated utilising a novel graphical representation of probability forecasts and used to generate high discharge scenarios. They highlight challenges for making decisions on the basis of hydrological predictions, and indicate the need for a tool to be used in addition to forecasts to compare the different mitigation actions possible in the Sihl catchment.

Mycobacterium avium subsp. paratuberculosis infection, immunology and pathology of livestock

USDA-ARS?s Scientific Manuscript database

Mycobacterium avium subsp. paratuberculosis (MAP) infection in ruminants leads to a chronic and progressive enteric disease (Johne’s disease) that results in loss of intestinal function, poor body condition, and eventual death. Transmission is primarily through a fecal-oral route in neonates but con...

A simple test procedure for evaluating low temperature crack resistance of asphalt concrete : executive summary report.

DOT National Transportation Integrated Search

2009-03-01

Low temperature cracking is one of the major : distress modes in asphalt pavement and is : disastrous to pavement performance and service : life. A poor riding surface leads to an increase in : maintenance and eventual early replacement of : the pave...

Exploring Trilingual Code-Switching: The Case of "Hokaglish"

ERIC Educational Resources Information Center

Gonzales, Wilkinson Daniel Wong

2016-01-01

This paper presents findings of an initial study on a trilingual code-switching (CS) phenomenon called "Hokaglish" in Binondo, Manila, The Philippines. Beginning with descriptions of multiculturalism and multilingualism in the Philippines, the discussion eventually leads to the description and survey of the code-switching phenomenon…

Polish Foreign and Security Policy: Dilemmas of Multi-National Integration and Alliance Cohesion, 1989-2005

DTIC Science & Technology

2005-06-01

Administration into providing guarantees leading toward eventual NATO membership. Polish-Americans lobbied Congress; Zbigniew Brzezinski applied...Minister, Admiral Piotr Kolodziejczyk, at the Drawsko military training ground. At a dinner in which all of the participants listed above were present

The Founding Fathers: Choosing to Be the Romans.

ERIC Educational Resources Information Center

Venables, Robert W.

1989-01-01

Reviews Iroquois influences on historical processes leading to the U.S. Constitution and on its philosophical intent and content. Argues that the Founding Fathers drew parallels between native confederacies and ancestral European tribes, and eventually rejected confederated government because the more unified Romans conquered the tribes. Contains…

Neglected child with substance abuse leading to child abuse: a case report.

PubMed

Subramanian, E M G; Subhagya, B; Muthu, M S; Sivakumar, N

2005-06-01

Child abuse and neglect is any interaction or lack of interaction between a caregiver and a child resulting in nonaccidental harm to the child's physical and developmental state. Substance abuse is ingestion of any drug, which is capable of altering the mental functioning eventually leading to addiction. This paper presents a case report of a 12-year-old neglected girl with substance abuse for which she was physically abused by her mother.

The role of pore fluids on deforming volcanic rocks: an experimental study

NASA Astrophysics Data System (ADS)

Fazio, Marco; Benson, Philip; Vinciguerra, Sergio; Meredith, Philip

2015-04-01

Pore fluids play an important role on the process of the deformation of rocks. Not only it affects the mechanical properties and the elastic velocities of the material, but it is also responsible in the generation of a whole kind of seismicity, characterized by lower frequency and longer tail (i.e. Long Period, LP, and Hybrid events) than the Volcano-Tectonic (VT) signals, generated by simple shear. While great progress has been made in understanding VT events, LPs, Hybrid signals and the transition between these types of activity are not fully understood yet. This study, aiming in particular on the transition between VT and Hybrid events, shows the results of triaxial experiments on a volcanic rock, run both in dry and wet conditions, to better understand the role of the pore fluids on the final stage of the deformation tests, when the sample is approaching failure. This is achieved through a servo-controlled triaxial testing machine and a state-of the-art acoustic emissions (AEs) kit, composed by an array of 12 piezoelectric sensors surrounding the sample and by both a "triggered" unit, where the events are recorded only if a certain threshold is reached, and a "continuous" unit, where the data is recorded from the beginning to the end of the acquisition, fundamental when the AEs grow exponentially and the triggered unit cannot store at the same rate. The use of sensors of different dominant frequency allows us to better investigate the events occurring as the sample is approaching failure. In both conditions we observe a decrease of the dominant frequency of the seismic activity, due to two different processes: in dry conditions the coalescence of fractures, eventually leading to the major shear zone, creates relatively low-frequency VT events; the same occurs in wet conditions, but the movement of fluids, eased by the merging of the cracks, generates hybrid events. These two type of seismicity are then distinguished in terms of their source mechanism components, where the low-frequency VTs are characterized by a higher DC component, while hybrid events show a greater CLVD one. These results may have a great impacts in the failure forecasting models, not only in volcanic settings, but wherever the pore fluids play an important role on the stability of the rock mass.

The Importance of First Impressions: Early Events in Mycobacterium tuberculosis Infection Influence Outcome.

PubMed

Cadena, Anthony M; Flynn, JoAnne L; Fortune, Sarah M

2016-04-05

Tuberculosis remains a major health threat in much of the world. New vaccines against Mycobacterium tuberculosis are essential for preventing infection, disease, and transmission. However, the host immune responses that need to be induced by an effective vaccine remain unclear. Increasingly, it has become clear that early events in infection are of major importance in the eventual outcome of the infection. Studying such events in humans is challenging, as they occur within the lung and thoracic lymph nodes, and any clinical signs of early infection are relatively nonspecific. Nonetheless, clinical studies and animal models of tuberculosis have provided new insights into the local events that occur in the first few weeks of tuberculosis. Development of an effective vaccine requires a clear understanding of the successful (and detrimental) early host responses against M. tuberculosis, with the goal to improve upon natural immune responses and prevent infection or disease. Copyright © 2016 Cadena et al.

Attrition and Retention of Apprentices: An Exploration of Event History Data Using a Multi-State Modelling Framework

ERIC Educational Resources Information Center

Mangan, John; Trendle, Bernard

2017-01-01

There is widespread public concern at the high drop-out rates among apprentices in Australia. This paper argues that this concern may be misplaced as it fails to allow for eventual completion over time. We argue that a methodology that concentrates on a single training episode only is less appropriate to evaluating training outcomes in a regime…

Effects of Temperature and Drought Stress on Physiological Processes Associated With Oak Decline

Treesearch

Theodor D. Leininger

1998-01-01

Oak decline is a term used to describe a sequence of events (decline syndrome) which is typically triggered by anabioticstress and subsequently involves other biotic and abiotic factors that cause the progressive deterioration and eventual death of a tree. Decline diseases lack a single causal agent, and in that way are different from diseases caused by one pathogen or...

Late Quaternary environmental and human events at En Gedi, reflected by the geology and archaeology of the Moringa Cave (Dead Sea area, Israel)

NASA Astrophysics Data System (ADS)

Lisker, Sorin; Porat, Roi; Davidovich, Uri; Eshel, Hanan; Lauritzen, Stein-Erik; Frumkin, Amos

2007-09-01

The Moringa Cave within Pleistocene sediments in the En Gedi area of the Dead Sea Fault Escarpment contains a sequence of various Pleistocene lacustrine deposits associated with higher-than-today lake levels at the Dead Sea basin. In addition it contains Chalcolithic remains and 5th century BC burials attributed to the Persian period, cemented and covered by Late Holocene travertine flowstone. These deposits represent a chain of Late Pleistocene and Holocene interconnected environmental and human events, echoing broader scale regional and global climate events. A major shift between depositional environments is associated with the rapid fall of Lake Lisan level during the latest Pleistocene. This exposed the sediments, providing for cave formation processes sometime between the latest Pleistocene (ca. 15 ka) and the Middle Holocene (ca. 4500 BC), eventually leading to human use of the cave. The Chalcolithic use of the cave can be related to a relatively moist desert environment, probably related to a shift in the location of the northern boundary of the Saharo-Arabian desert belt. The travertine layer was U-Th dated 2.46 ± 0.10 to 2.10 ± 0.04 ka, in agreement with the archaeological finds from the Persian period. Together with the inner consistency of the dating results, this strongly supports the reliability of the radiometric ages. The 2.46-2.10 ka travertine deposition within the presently dry cave suggests a higher recharge of the Judean Desert aquifer, correlative to a rising Dead Sea towards the end of the 1st millennium BC. This suggests a relatively moist local and regional climate facilitating human habitation of the desert.

The stereotypical molecular cascade in neovascular age-related macular degeneration: the role of dynamic reciprocity.

PubMed

Kent, D

2015-11-01

This review summarises our current understanding of the molecular basis of subretinal neovascularisation (SRNV) in age-related macular degeneration (AMD). The term neovascular AMD (NVAMD) is derived from the dominant early clinical features of haemorrhage, fluid, and lipid in the subretinal space (SRS) and the historical role of fluorescein angiography in detecting the presence of NV tissue. However, at the cellular level, SRNV resembles an aberrant but stereotypical tissue repair response that incorporates both an early inflammatory phase and a late fibrotic phase in addition to the neovascular (NV) component that dominates the early clinical presentation. This review will seek not only to highlight the important molecules involved in each of these components but to demonstrate that the development of SRNV has its origins in the earliest events in non-NV AMD pathogenesis. Current evidence suggests that this early-stage pathogenesis is characterised by complement-mediated immune dysregulation, leading to a state of chronic inflammation in the retinal pigment epithelium/Bruch's membrane/choriocapillaris complex. These initial events can be seamlessly and inextricably linked to late-stage development of SRNV in AMD by the process of dynamic reciprocity (DyR), the ongoing bidirectional communication between cells, and their surrounding matrix. Moreover, this correlation between disease onset and eventual outcome is reflected in the temporal and spatial correlation between chronic inflammation, NV, and fibrosis within the reparative microenvironment of the SRS. In summary, the downstream consequences of the earliest dysfunctional molecular events in AMD can result in the late-stage entity we recognize clinically as SRNV and is characterized by a spectrum of predictable, related, and stereotypical processes referred to as DyR.

Breakdown of the conservative potential equation

NASA Technical Reports Server (NTRS)

Salas, M. D.; Gumbert, C. R.

1986-01-01

The conservative full-potential equation is used to study transonic flow over five airfoil sections. The results of the study indicate that once shock are present in the flow, the qualitative approximation is different from that observed with the Euler equations. The difference in behavior of the potential eventually leads to multiple solutions.

Long-term nitrogen fertilization increases winter injury in montane red spruce foliage (Picea rubens) foliage

Treesearch

T.D. Perkins; G.T. Adams; S.T. Lawson; P.G. Schaberg; S.G. McNulty

2000-01-01

Current-year red spruce (Picea rubens Sarg.) foliage is predisposed to winter injury by one or more types of anthropogenic pollutants, particularly acidic deposition. The resultant defoliation, when severe and repeated, leads to dieback and eventual mortality of affected red spruce individuals

Development of a two-step, non-probed multiplex real-time PCR for surveilling Vibrio anguillarum in seawater

USDA-ARS?s Scientific Manuscript database

Vibrio anguillarum is an aggressive and halophilic bacterial pathogen commonly found in seawater. Its presence in aquaculture facilities causes significant morbidity and mortality among aquaculture species primarily from hemorrhaging of the body and skin of the infected fish that eventually leads t...

Math and Mind Mapping: Origami Construction

ERIC Educational Resources Information Center

Sze, Susan

2005-01-01

Students with or without disabilities often experience difficulties with abstract math concepts. This paper is intended to help solve the mystery of math concepts through origami construction, a hands-on activity. Students are involved in constructing and deconstructing concepts by folding and unfolding a piece of paper which eventually leads to a…

Practical application of cure mixture model for long-term censored survivor data from a withdrawal clinical trial of patients with major depressive disorder.

PubMed

Arano, Ichiro; Sugimoto, Tomoyuki; Hamasaki, Toshimitsu; Ohno, Yuko

2010-04-23

Survival analysis methods such as the Kaplan-Meier method, log-rank test, and Cox proportional hazards regression (Cox regression) are commonly used to analyze data from randomized withdrawal studies in patients with major depressive disorder. However, unfortunately, such common methods may be inappropriate when a long-term censored relapse-free time appears in data as the methods assume that if complete follow-up were possible for all individuals, each would eventually experience the event of interest. In this paper, to analyse data including such a long-term censored relapse-free time, we discuss a semi-parametric cure regression (Cox cure regression), which combines a logistic formulation for the probability of occurrence of an event with a Cox proportional hazards specification for the time of occurrence of the event. In specifying the treatment's effect on disease-free survival, we consider the fraction of long-term survivors and the risks associated with a relapse of the disease. In addition, we develop a tree-based method for the time to event data to identify groups of patients with differing prognoses (cure survival CART). Although analysis methods typically adapt the log-rank statistic for recursive partitioning procedures, the method applied here used a likelihood ratio (LR) test statistic from a fitting of cure survival regression assuming exponential and Weibull distributions for the latency time of relapse. The method is illustrated using data from a sertraline randomized withdrawal study in patients with major depressive disorder. We concluded that Cox cure regression reveals facts on who may be cured, and how the treatment and other factors effect on the cured incidence and on the relapse time of uncured patients, and that cure survival CART output provides easily understandable and interpretable information, useful both in identifying groups of patients with differing prognoses and in utilizing Cox cure regression models leading to meaningful interpretations.

Mantle-crust interaction at the Blanco Ridge segment of the Blanco Transform Fault Zone: Results from the Blanco Transform Fault OBS Experiment

NASA Astrophysics Data System (ADS)

Kuna, V. M.; Nabelek, J.; Braunmiller, J.

2016-12-01

We present results of the Blanco Transform OBS Experiment, which consists of the deployment of 55 three-component broadband and short-period ocean bottom seismometers in the vicinity of the Blanco Fault Zone for the period between September 2012 and October 2013. Our research concentrates on the Blanco Ridge, a purely transform segment of the Blanco Fault Zone, that spans over 130 km between the Cascadia and the Gorda pull-apart depressions. Almost 3,000 well-constrained earthquakes were detected and located along the Blanco Ridge by an automatic procedure (using BRTT Antelope) and relocated using a relative location algorithm (hypoDD). The catalog magnitude of completeness is M=2.2 with an overall b value of 1. Earthquakes extend from 0 km to 20 km depth, but cluster predominantly at two depth levels: in the crust (5-7 km) and in the uppermost mantle (12-17 km). Statistical analysis reveals striking differences between crustal and mantle seismicity. The temporal distribution of crustal events follows common patterns given by Omori's law, while most mantle seismicity occurs in spatially tight sequences of unusually short durations lasting 30 minutes or less. These sequences cannot be described by known empirical laws. Moreover, we observe increased seismic activity in the uppermost mantle about 30 days before the largest (M=5.4) earthquake. Two mantle sequences occurred in a small area of 3x3 km about 4 and 2 weeks before the M=5.4 event. In the week leading up to the M=5.4 event we observe a significant downward migration of crustal seismicity, which results in the subsequent nucleation of the main event at the base of the crust. We hypothesize that the highly localized uppermost mantle seismicity is triggered by aseismic slow-slip of the surrounding ductile mantle. We also suggest that the mantle slip loads the crust eventually resulting in relatively large crustal earthquakes.

Compression of self-assembled nano-objects: 2D/3D transitions in films of (perfluoroalkyl)alkanes--persistence of an organized array of surface micelles.

PubMed

de Gracia Lux, Caroline; Gallani, Jean-Louis; Waton, Gilles; Krafft, Marie Pierre

2010-06-25

Understanding and controlling the molecular organization of amphiphilic molecules at interfaces is essential for materials and biological sciences. When spread on water, the model amphiphiles constituted by C(n)F(2n+1)C(m)H(2m+1) (FnHm) diblocks spontaneously self-assemble into surface hemimicelles. Therefore, compression of monolayers of FnHm diblocks is actually a compression of nanometric objects. Langmuir films of F8H16, F8H18, F8H20, and F10H16 can actually be compressed far beyond the "collapse" of their monolayers at approximately 30 A(2). For molecular areas A between 30 and 10 A(2), a partially reversible, 2D/3D transition occurs between a monolayer of surface micelles and a multilayer that coexist on a large plateau. For A<10 A(2), surface pressure increases again, reaching up to approximately 48 mN m(-1) before the film eventually collapses. Brewster angle microscopy and AFM indicate a several-fold increase in film thickness when scanning through the 2D/3D coexistence plateau. Compression beyond the plateau leads to a further increase in film thickness and, eventually, to film disruption. Reversibility was assessed by using compression-expansion cycles. AFM of F8H20 films shows that the initial monolayer of micelles is progressively covered by one (and eventually two) bilayers, which leads to a hitherto unknown organized composite arrangement. Compression of films of the more rigid F10H16 results in crystalline-like inflorescences. For both diblocks, a hexagonal array of surface micelles is consistently seen, even when the 3D structures eventually disrupt, which means that this monolayer persists throughout the compression experiments. Two examples of pressure-driven transformations of films of self-assembled objects are thus provided. These observations further illustrate the powerful self-assembling capacity of perfluoroalkyl chains.

The Photoevaporation of a Neutral Structure by an EUV+FUV Radiation Field

NASA Astrophysics Data System (ADS)

Lora, Veronica; Vasconcelos, M. J.; Raga, A. C.; Cerqueira, A. H.; Esquivel, A.

The expansion of an HII region into a surrounding inhomogeneous molecular cloud, leads to the formation of elongated "elephant trunk" structures. The EUV photo-ionising radiation and FUV dissociating radiation from newly born stars photo-evaporate their parental neutral cloud, leading to the formation of dense clumps in the tips of elephant trunks, that could in principle eventually form stars. We study th effects of including a photo-dissociating FUV flux in models of fragmentation of a photo-evaporating, self-gravitating molecular cloud.

Patient satisfaction is a best practice.

PubMed

2009-10-01

There are several best practices ED physicians and nurses can adopt to minimize the likelihood of a lawsuit, but perhaps none is more important than ensuring high patient satisfaction scores. Research shows a definite correlation between increasing patient satisfaction and decreasing the medical malpractice frequency. Bad outcomes are more likely to lead to lawsuits if the patient doesn't like their doctor or nurse. Being attuned to patients and their perspective is one of the best ways to prevent complaints, which eventually can lead to lawsuits.

Lead toxicity masquerading as sickle cell crisis.

PubMed

Nelson, M S; Chisolm, J J

1986-06-01

We recently saw a 12-year-old black boy with known sickle cell disease who had been seen many times for abdominal pain thought to be secondary to a vasoocclusive crisis. The patient eventually was admitted, after a seizure and the onset of obtundation. The etiology of his acute encephalopathy remained unclear until bone films of his knees fortuitously revealed "lead lines." The patient was treated and did well subsequently. This case emphasizes the importance of considering other diagnoses when a sickle cell patient presents with a crisis.

Serine/Threonine Protein Phosphatase PstP of Mycobacterium tuberculosis Is Necessary for Accurate Cell Division and Survival of Pathogen*

PubMed Central

Sharma, Aditya K.; Arora, Divya; Singh, Lalit K.; Gangwal, Aakriti; Sajid, Andaleeb; Molle, Virginie; Singh, Yogendra; Nandicoori, Vinay Kumar

2016-01-01

Protein phosphatases play vital roles in phosphorylation-mediated cellular signaling. Although there are 11 serine/threonine protein kinases in Mycobacterium tuberculosis, only one serine/threonine phosphatase, PstP, has been identified. Although PstP has been biochemically characterized and multiple in vitro substrates have been identified, its physiological role has not yet been elucidated. In this study, we have investigated the impact of PstP on cell growth and survival of the pathogen in the host. Overexpression of PstP led to elongated cells and partially compromised survival. We find that depletion of PstP is detrimental to cell survival, eventually leading to cell death. PstP depletion results in elongated multiseptate cells, suggesting a role for PstP in regulating cell division events. Complementation experiments performed with PstP deletion mutants revealed marginally compromised survival, suggesting that all of the domains, including the extracellular domain, are necessary for complete rescue. On the other hand, the catalytic activity of PstP is absolutely essential for the in vitro growth. Mice infection experiments establish a definitive role for PstP in pathogen survival within the host. Depletion of PstP from established infections causes pathogen clearance, indicating that the continued presence of PstP is necessary for pathogen survival. Taken together, our data suggest an important role for PstP in establishing and maintaining infection, possibly via the modulation of cell division events. PMID:27758870

Does pressure cause liver cirrhosis? The sinusoidal pressure hypothesis

PubMed Central

Mueller, Sebastian

2016-01-01

Independent of their etiology, all chronic liver diseases ultimately lead to liver cirrhosis, which is a major health problem worldwide. The underlying molecular mechanisms are still poorly understood and no efficient treatment strategies are available. This paper introduces the sinusoidal pressure hypothesis (SPH), which identifies an elevated sinusoidal pressure (SP) as cause of fibrosis. SPH has been mainly derived from recent studies on liver stiffness. So far, pressure changes have been exclusively seen as a consequence of cirrhosis. According to the SPH, however, an elevated SP is the major upstream event that initiates fibrosis via biomechanic signaling by stretching of perisinusoidal cells such as hepatic stellate cells or fibroblasts (SPH part I: initiation). Fibrosis progression is determined by the degree and time of elevated SP. The SPH predicts that the degree of extracellular matrix eventually matches SP with critical thresholds > 12 mmHg and > 4 wk. Elevated arterial flow and final arterialization of the cirrhotic liver represents the self-perpetuating key event exposing the low-pressure-organ to pathologically high pressures (SPH part II: perpetuation). It also defines the “point of no return” where fibrosis progression becomes irreversible. The SPH is able to explain the macroscopic changes of cirrhotic livers and the uniform fibrotic response to various etiologies. It also opens up new views on the role of fat and disease mechanisms in other organs. The novel concept will hopefully stimulate the search for new treatment strategies. PMID:28082801

Discovery of Novel Virulence Factors of Biothreat Agents: Validation of the Phosphoproteome-Based Approach

DTIC Science & Technology

2007-06-01

minutes of infection these pathways focus on the production proteins that will regulate pro- inflammatory cytokines, chemotaxis cytokines, apoptosis, and...cytoskeleton rearrangement. The production of these proteins and events will eventually elicit a total innate immune system response. However...decreases the innate immune system response (16). The lack of proper cytokine Figure 7 - 14 - production might be caused by Francisella’s ability to

Considerations For Distributed Short Takeoff Vertical Landing (STOVL) Operations

DTIC Science & Technology

2015-05-18

intended to confuse the enemy through non-linear operations by creating a network of highly-capable battalion to squad sized units spread across the...the next iteration was named Enhanced Company Operations ( ECO ). Here, the infantry Company became the focus of the distributed concept... friendly battlefield against the MAGTF commander’s idea. As events progress over time, the enemy can eventually target the remaining defended M-FARPs and

Final Report for DUSEL R&D: BetaCage: A Screener of Ultra-Low-Level Radioactive Surface Contamination

DOE Office of Scientific and Technical Information (OSTI.GOV)

Golwala, Sunil R.

2013-12-20

The eventual full-size, radiopure BetaCage will be a low-background, atmospheric-pressure neon drift chamber with unprecedented sensitivity to emitters of low-energy electrons and alpha particles. We expect that the prototype BetaCage already developed will be an excellent screener of alpha particles. Both the prototype and final BetaCage will provide new infrastructure for rare-event science.

Proteomics goes forensic: Detection and mapping of blood signatures in fingermarks.

PubMed

Deininger, Lisa; Patel, Ekta; Clench, Malcolm R; Sears, Vaughn; Sammon, Chris; Francese, Simona

2016-06-01

A bottom up in situ proteomic method has been developed enabling the mapping of multiple blood signatures on the intact ridges of blood fingermarks by Matrix Assisted Laser Desorption Mass Spectrometry Imaging (MALDI-MSI). This method, at a proof of concept stage, builds upon recently published work demonstrating the opportunity to profile and identify multiple blood signatures in bloodstains via a bottom up proteomic approach. The present protocol addresses the limitation of the previously developed profiling method with respect to destructivity; destructivity should be avoided for evidence such as blood fingermarks, where the ridge detail must be preserved in order to provide the associative link between the biometric information and the events of bloodshed. Using a blood mark reference model, trypsin concentration and spraying conditions have been optimised within the technical constraints of the depositor eventually employed; the application of MALDI-MSI and Ion Mobility MS have enabled the detection, confirmation and visualisation of blood signatures directly onto the ridge pattern. These results are to be considered a first insight into a method eventually informing investigations (and judicial debates) of violent crimes in which the reliable and non-destructive detection and mapping of blood in fingermarks is paramount to reconstruct the events of bloodshed. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Impacts of extreme weather events on transport infrastructure in Norway

NASA Astrophysics Data System (ADS)

Frauenfelder, Regula; Solheim, Anders; Isaksen, Ketil; Romstad, Bård; Dyrrdal, Anita V.; Ekseth, Kristine H. H.; Gangstø Skaland, Reidun; Harbitz, Alf; Harbitz, Carl B.; Haugen, Jan E.; Hygen, Hans O.; Haakenstad, Hilde; Jaedicke, Christian; Jónsson, Árni; Klæboe, Ronny; Ludvigsen, Johanna; Meyer, Nele K.; Rauken, Trude; Sverdrup-Thygeson, Kjetil

2016-04-01

With the latest results on expected future increase in air temperature and precipitation changes reported by the Intergovernmental Panel on Climate Change (IPCC), the climate robustness of important infrastructure is of raising concern in Norway, as well as in the rest of Europe. Economic consequences of natural disasters have increased considerably since 1950. In addition to the effect of demographic changes such as population growth, urbanization and more and more concentration of valuable assets, this increase is also related to an augmenting frequency of extreme events, such as storms, flooding, drought, and landslides. This change is also observable in Norway, where the increased frequency of strong precipitation has led to frequent flooding and landslide events during the last 20 years. A number of studies show that climate change causes an increase in both frequency and intensity of several types of extreme weather, especially when it comes to precipitation. Such extreme weather events greatly affect the transport infrastructure, with numerous and long closures of roads and railroads, in addition to damage and repair costs. Frequent closures of railroad and roads lead to delay or failure in delivery of goods, which again may lead to a loss of customers and/or - eventually - markets. Much of the Norwegian transport infrastructure is more than 50 years old and therefore not adequately dimensioned, even for present climatic conditions. In order to assess these problems and challenges posed to the Norwegian transport infrastructure from present-day and future extreme weather events, the project "Impacts of extreme weather events on infrastructure in Norway (InfraRisk)" was performed under the research Council of Norway program 'NORKLIMA', between 2009 and 2013. The main results of the project are: - Moderate to strong precipitation events have become more frequent and more intense in Norway over the last 50 years, and this trend continues throughout the 21st century. The increase, both in total precipitation, and in the frequency and intensity of extreme events, is greatest in the west and southwest, and in parts of northern Norway, areas with the highest present precipitation. - Snowfall will increase due to increased precipitation in cold areas inland and at high elevations. In lower lying parts of the country, and along the coast, more precipitation as rain will replace snowfall. - The frequency of near-zero events, with freeze-thaw cycles, which can trigger rock falls, will decrease due to the generally increased temperatures. - The greatest uncertainties in the weather trends are linked to uncertainties in climate and emission scenarios, and to the downscaling. - More than 30% of the total length of road and railroads in Norway is exposed to snow avalanche and rock fall/slide hazard. As an example, one of the most exposed railroads, Raumabanen, has an annual probability of 1/3 to be hit by snow avalanches. - Total costs of geohazard impact on the road infrastructure (major roads only) were estimated to be roughly 100 mill. NOK per year, of which the costs of road closures comprise 70%. The numbers are unevenly distributed throughout the country, reflecting the topographic and climatic variability in Norway.

Frailty and sarcopenia - newly emerging and high impact complications of diabetes.

PubMed

Sinclair, Alan J; Abdelhafiz, Ahmed H; Rodríguez-Mañas, Leocadio

2017-09-01

Diabetes increases the risk of physical dysfunction and disability. Diabetes-related complications and coexisting morbidities partially explain the deterioration in physical function. The decline in muscle mass, strength and function associated with diabetes leads to sarcopenia, frailty and eventually disability. Frailty acts as a mediator in the pathogenesis of disability in older people with diabetes and its measurement in routine daily practice is recommended. Frailty is a dynamic process which progresses from a robust condition to a pre-frail stage then frailty and eventually disability. Therefore, a multimodal intervention which includes adequate nutrition, exercise training, good glycaemic control and the use of appropriate hypoglycemic medications may help delay or prevent the progression to disability. Copyright © 2017 Elsevier Inc. All rights reserved.

The Serendipity of Principalship: Meaning-Making of a Filipino Secondary School Principal

ERIC Educational Resources Information Center

De Guzman, Allan B.; Guillermo, Maria Lirio Tan Lagrimas

2007-01-01

Meaning-making is vital in the realm of principalship. It serves as the fulcrum of one's practice which eventually leads to seeing the light and appreciating the serendipity of principalship. While explicit knowledge abounds in the literature and is communicated in professional development programs, the role of the principals' tacit knowledge…

THE EFFECT OF PHOSPHATE ON THE MORPHOLOGICAL AND SPECTROSCOPIC PROPERTIES OF COPPER DRINKING WATER PIPES EXPERIENCING LOCALIZED CORROSION

EPA Science Inventory

Extensive localized or pitting corrosion of copper pipes used in household drinking-water plumbing can eventually lead to pinhole water leaks that may result in water damage, mold growth, and costly repairs. A large water system in Florida has been addressing a widespread pinhole...

The Effect of Phosphate on the Morphological and Spectroscopic Properties of Copper Pipes Experiencing Localized Corrosion

EPA Science Inventory

Extensive localized or pitting corrosion of copper pipes used in household drinking-water plumbing can eventually lead to pinhole water leaks that may result in water damage, mold growth, and costly repairs. A growing number of problems have been associated with high pH and low ...

The Psychophysiological Impact of Burnout in Special and General Education Teachers

ERIC Educational Resources Information Center

Sacco, Matthew D. F.

2011-01-01

Teaching is considered to be a stressful occupation. Many teachers experience ongoing stress from a variety of sources, which eventually leads to burnout, and ultimately is reflected in what has become an alarming rate of attrition. The present study examined the relationship between teachers' experiences of stress, burnout, and salivary cortisol…

The Juvenile and Adolescent Substance Abuse Prevention Program: An Evaluation

ERIC Educational Resources Information Center

Talpade, Medha; Lynch, Diane; Lattimore, Barbara; Graham, Ashlee

2008-01-01

The Juvenile and Adolescent Substance Abuse Prevention Program (JASAP) is a curriculum-based prevention and health promotion program for youth between the ages of 13 to 18 years in Fulton County, Georgia. The program was established in 2007 to promote healthy decision-making skills that would eventually lead to informed choices and decisions…

Using Situational Interest to Enhance Individual Interest and Science-Related Behaviours

ERIC Educational Resources Information Center

Palmer, David; Dixon, Jeanette; Archer, Jennifer

2017-01-01

Situational interest is a relatively transient reaction to highly stimulating factors in the immediate environment, whereas individual interest is a relatively long-term preference for a particular subject or activity. It has been proposed that regular experiences of situational interest in a subject may eventually lead to the development of…

Displaced Worker Transition Programs: Leading the Workforce Back to Community Colleges.

ERIC Educational Resources Information Center

Walters, Greg; And Others

In response to the increasing numbers of displaced workers due to corporate downsizing, Pellissippi State Technical Community College, in Tennessee, has initiated the Workplace Innovation (WIN) Project to help adults gain prerequisite academic and personal skills to re-enter the workforce or enter college for eventual placement in higher-paying…

Factors That Impact Teacher Power in Decision-Making in U.S. Public Schools: A Multilevel Analysis

ERIC Educational Resources Information Center

Wang, Yuling

2015-01-01

The teacher empowerment process emphasizes professional development and participation (i.e., increasing professional status, skills, knowledge and providing the opportunity to participate in decision-making); however, whether these efforts eventually lead to the realization of teacher power remains a critical concern, especially considering that…

The Causes and Effects of English Teachers' Turnover: A Case from Afghanistan

ERIC Educational Resources Information Center

Khawary, Omidullah; Ali, Sajid

2015-01-01

One of the challenging issues that educational organizations in developing countries face in staffing classrooms with qualified teachers is the high rate of teachers' turnover. It creates problems for schools, which eventually leads to substandard instruction and low student achievement. This research explores the causes of English teachers'…

75 FR 58372 - Notice of Intent To Prepare an Environmental Impact Statement for Skokomish General Investigation...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-24

... sediment load, reduced flows, and encroachment of the floodplain by man-made structures are leading to... frequent flooding of local roads, two state highways, agricultural fields, residences, and other structures... approximate 240 square mile drainage basin, and eventually flows into southern Hood Canal, an arm of Puget...

Educational Biotechnology and a Search for Moral Opposition to It.

ERIC Educational Resources Information Center

Nichols, Randall G.

This paper argues that several aspects of educational technology, especially educational biotechnology (EBT), are harmful to people and the environment, and will eventually lead to harms that far out-weigh any purported advantages of the technology, and that this is morally unacceptable. (EBT is characterized as the study and application of…

Early Boost and Slow Consolidation in Motor Skill Learning

ERIC Educational Resources Information Center

Hotermans, Christophe; Peigneux, Philippe; de Noordhout, Alain Maertens; Moonen, Gustave; Maquet, Pierre

2006-01-01

Motor skill learning is a dynamic process that continues covertly after training has ended and eventually leads to delayed increments in performance. Current theories suggest that this off-line improvement takes time and appears only after several hours. Here we show an early transient and short-lived boost in performance, emerging as early as…

Reconsidering the Relationship between Air Pollution and Deprivation

PubMed Central

Bailey, Nick; Dong, Guanpeng; Minton, Jon; Pryce, Gwilym

2018-01-01

This paper critically examines the relationship between air pollution and deprivation. We argue that focusing on a particular economic or social model of urban development might lead one to erroneously expect all cities to converge towards a particular universal norm. A naive market sorting model, for example, would predict that poor households will eventually be sorted into high pollution areas, leading to a positive relationship between air pollution and deprivation. If, however, one considers a wider set of theoretical perspectives, the anticipated relationship between air pollution and deprivation becomes more complex and idiosyncratic. Specifically, we argue the relationship between pollution and deprivation can only be made sense of by considering processes of risk perception, path dependency, gentrification and urbanization. Rather than expecting all areas to eventually converge to some universal norm, we should expect the differences in the relationship between air pollution and deprivation across localities to persist. Mindful of these insights, we propose an approach to modeling which does not impose a geographically fixed relationship. Results for Scotland reveal substantial variations in the observed relationships over space and time, supporting our argument. PMID:29596380

Reconsidering the Relationship between Air Pollution and Deprivation.

PubMed

Bailey, Nick; Dong, Guanpeng; Minton, Jon; Pryce, Gwilym

2018-03-29

This paper critically examines the relationship between air pollution and deprivation. We argue that focusing on a particular economic or social model of urban development might lead one to erroneously expect all cities to converge towards a particular universal norm. A naive market sorting model, for example, would predict that poor households will eventually be sorted into high pollution areas, leading to a positive relationship between air pollution and deprivation. If, however, one considers a wider set of theoretical perspectives, the anticipated relationship between air pollution and deprivation becomes more complex and idiosyncratic. Specifically, we argue the relationship between pollution and deprivation can only be made sense of by considering processes of risk perception, path dependency, gentrification and urbanization. Rather than expecting all areas to eventually converge to some universal norm, we should expect the differences in the relationship between air pollution and deprivation across localities to persist. Mindful of these insights, we propose an approach to modeling which does not impose a geographically fixed relationship. Results for Scotland reveal substantial variations in the observed relationships over space and time, supporting our argument.

A viscoplastic shear-zone model for episodic slow slip events in oceanic subduction zones

NASA Astrophysics Data System (ADS)

Yin, A.; Meng, L.

2016-12-01

Episodic slow slip events occur widely along oceanic subduction zones at the brittle-ductile transition depths ( 20-50 km). Although efforts have been devoted to unravel their mechanical origins, it remains unclear about the physical controls on the wide range of their recurrence intervals and slip durations. In this study we present a simple mechanical model that attempts to account for the observed temporal evolution of slow slip events. In our model we assume that slow slip events occur in a viscoplastic shear zone (i.e., Bingham material), which has an upper static and a lower dynamic plastic yield strength. We further assume that the hanging wall deformation is approximated as an elastic spring. We envision the shear zone to be initially locked during forward/landward motion but is subsequently unlocked when the elastic and gravity-induced stress exceeds the static yield strength of the shear zone. This leads to backward/trenchward motion damped by viscous shear-zone deformation. As the elastic spring progressively loosens, the hanging wall velocity evolves with time and the viscous shear stress eventually reaches the dynamic yield strength. This is followed by the termination of the trenchward motion when the elastic stress is balanced by the dynamic yield strength of the shear zone and the gravity. In order to account for the zig-saw slip-history pattern of typical repeated slow slip events, we assume that the shear zone progressively strengthens after each slow slip cycle, possibly caused by dilatancy as commonly assumed or by progressive fault healing through solution-transport mechanisms. We quantify our conceptual model by obtaining simple analytical solutions. Our model results suggest that the duration of the landward motion increases with the down-dip length and the static yield strength of the shear zone, but decreases with the ambient loading velocity and the elastic modulus of the hanging wall. The duration of the backward/trenchward motion depends on the thickness, viscosity, and dynamic yield strength of the shear zone. Our model predicts a linear increase in slip with time during the landward motion and an exponential decrease in slip magnitude during the trenchward motion.

Smokeless tobacco (paan and gutkha) consumption, prevalence, and contribution to oral cancer

PubMed Central

2017-01-01

Smokeless tobacco consumption, which is widespread throughout the world, leads to oral submucous fibrosis (OSMF), which is a long-lasting and devastating condition of the oral cavity with the potential for malignancy. In this review, we mainly focus on the consumption of smokeless tobacco, such as paan and gutkha, and the role of these substances in the induction of OSMF and ultimately oral cancer. The list of articles to be examined was established using citation discovery tools provided by PubMed, Scopus, and Google Scholar. The continuous chewing of paan and swallowing of gutkha trigger progressive fibrosis in submucosal tissue. Generally, OSMF occurs due to multiple risk factors, especially smokeless tobacco and its components, such as betel quid, areca nuts, and slaked lime, which are used in paan and gutkha. The incidence of oral cancer is higher in women than in men in South Asian countries. Human oral epithelium cells experience carcinogenic and genotoxic effects from the slaked lime present in the betel quid, with or without areca nut. Products such as 3-(methylnitrosamino)-proprionitrile, nitrosamines, and nicotine initiate the production of reactive oxygen species in smokeless tobacco, eventually leading to fibroblast, DNA, and RNA damage with carcinogenic effects in the mouth of tobacco consumers. The metabolic activation of nitrosamine in tobacco by cytochrome P450 enzymes may lead to the formation of N-nitrosonornicotine, a major carcinogen, and micronuclei, which are an indicator of genotoxicity. These effects lead to further DNA damage and, eventually, oral cancer. PMID:28292008

A qualitative study of medical students in a rural track: views on eventual rural practice.

PubMed

Roseamelia, Carrie; Greenwald, James L; Bush, Tiffany; Pratte, Morgan; Wilcox, Jessica; Morley, Christopher P

2014-04-01

Rural tracks (RTs) exist within medical schools across the United States. These programs often target those students from rural areas and those with primary care career interests, given that these factors are robust predictors of eventual rural practice. However, only 26% to 64% of graduates from RTs enter eventual rural practice. We conducted a qualitative, exploratory study of medical students enrolled in one school's RT, examining their interests in rural training, specialization, and eventual rural practice, via open coding of transcripts from focus groups and in-depth individual interviews, leading to identification of emerging themes. A total of 16 out of 54 eligible first- and second-year preclinical medical students participated in focus group sessions, and a total of seven out of 17 eligible third- and fourth-year medical students participated in individual interviews. Analyses revealed the recognition of a "Rural Identity," typical characteristics, and the importance of "Program Fit" and "Intentions for Practice" that trended toward family medicine specialization and rural practice. However, nuances within the comments reveal incomplete commitment to rural practice. In many cases, student preference for rural practice was driven largely by a disinterest in urban practice. Students with rural and primary care practice interests are often not perfectly committed to rural practice. However, RTs may provide a haven for such students within medical school.

Negative life events have detrimental effects on in-vitro fertlization outcome.

PubMed

Yilmaz, Nafiye; Kahyaoglu, İnci; İnal, Hasan Ali; Görkem, Ümit; Devran, Aysun; Mollamahmutoglu, Leyla

2015-09-01

The aim of this study was to investigate the effect of negative life events on in-vitro-fertilization (IVF) outcome. Depression and negative life events were measured using Beck Depression Inventory (BDI) and List of Recent Events in 83 women attending the IVF clinic of a tertiary research and education hospital with the diagnosis of unexplained infertility between January 2013 and August 2013. Demographic features, stimulation parameters, depression scores, and negative life events of pregnant and non-pregnant participants were compared and the relation between negative life events, depression scores, and IVF outcome was investigated. Women who did not achieve a pregnancy experienced more negative life events than women who became pregnant (77.2% vs. 23.1%) (p > 0.001). The number of patients with moderate-to-severe depression (BDI scores > 16) was higher in the non-pregnant group than pregnant group (49.1% vs. 26.9%), however the difference was not statistically significant (p = 0.057). Clinical pregnancy showed a significant moderate negative correlation with the number of negative life events (r = -0.513, p = 0.001), but the correlation between clinical pregnancy and BDI scores was not statistically significant (r = -0.209, p = 0.059). Stressful life events have a negative influence on the quality of life, which eventually affects in IVF outcome, possibly through maladaptive lifestyle behavior.

An unusual cause of post-operative orbital edema in a child after general anesthesia

PubMed Central

Tobias, Joseph D.; Jagannathan, Narasimhan; Sawardekar, Amod; Bhalla, Tarun

2011-01-01

We present an unusual ocular complication during the perioperative period, bilateral orbital edema in an otherwise healthy child after an outpatient surgical procedure. Ocular complications under general anesthesia remain a rare event. When periorbital edema is present, the appropriate work-up includes ruling out the potential for an allergic event by reviewing the medications administered and serum tryptase testing. Ophthalmology consultation should be considered to exclude pathology native to the eye itself. An allergist may assist in confirming a diagnosis and for allergic testing, if indicated. In our patient, the eventual diagnosis of exclusion was that of a localized reaction to the cellophane-based eye tape. PMID:21655032

An unusual cause of post-operative orbital edema in a child after general anesthesia.

PubMed

Tobias, Joseph D; Jagannathan, Narasimhan; Sawardekar, Amod; Bhalla, Tarun

2011-01-01

We present an unusual ocular complication during the perioperative period, bilateral orbital edema in an otherwise healthy child after an outpatient surgical procedure. Ocular complications under general anesthesia remain a rare event. When periorbital edema is present, the appropriate work-up includes ruling out the potential for an allergic event by reviewing the medications administered and serum tryptase testing. Ophthalmology consultation should be considered to exclude pathology native to the eye itself. An allergist may assist in confirming a diagnosis and for allergic testing, if indicated. In our patient, the eventual diagnosis of exclusion was that of a localized reaction to the cellophane-based eye tape.

Spontaneous rupture of ovarian cystadenocarcinoma: pre- and post-rupture computed tomography evaluation*

PubMed Central

Salvadori, Priscila Silveira; Bomfim, Lucas Novais; von Atzingen, Augusto Castelli; D’Ippolito, Giuseppe

2015-01-01

Epithelial ovarian tumors are the most common malignant ovarian neoplasms and, in most cases, eventual rupture of such tumors is associated with a surgical procedure. The authors report the case of a 54-year-old woman who presented with spontaneous rupture of ovarian cystadenocarcinoma documented by computed tomography, both before and after the event. In such cases, a post-rupture staging tends to be less favorable, compromising the prognosis. PMID:26543286

High-resolution Hydrodynamic Simulation of Tidal Detonation of a Helium White Dwarf by an Intermediate Mass Black Hole

NASA Astrophysics Data System (ADS)

Tanikawa, Ataru

2018-05-01

We demonstrate tidal detonation during a tidal disruption event (TDE) of a helium (He) white dwarf (WD) with 0.45 M ⊙ by an intermediate mass black hole using extremely high-resolution simulations. Tanikawa et al. have shown tidal detonation in results of previous studies from unphysical heating due to low-resolution simulations, and such unphysical heating occurs in three-dimensional (3D) smoothed particle hydrodynamics (SPH) simulations even with 10 million SPH particles. In order to avoid such unphysical heating, we perform 3D SPH simulations up to 300 million SPH particles, and 1D mesh simulations using flow structure in the 3D SPH simulations for 1D initial conditions. The 1D mesh simulations have higher resolutions than the 3D SPH simulations. We show that tidal detonation occurs and confirm that this result is perfectly converged with different space resolution in both 3D SPH and 1D mesh simulations. We find that detonation waves independently arise in leading parts of the WD, and yield large amounts of 56Ni. Although detonation waves are not generated in trailing parts of the WD, the trailing parts would receive detonation waves generated in the leading parts and would leave large amounts of Si group elements. Eventually, this He WD TDE would synthesize 56Ni of 0.30 M ⊙ and Si group elements of 0.08 M ⊙, and could be observed as a luminous thermonuclear transient comparable to SNe Ia.

Megasporogenesis and programmed cell death in Tillandsia (Bromeliaceae).

PubMed

Papini, Alessio; Mosti, Stefano; Milocani, Eva; Tani, Gabriele; Di Falco, Pietro; Brighigna, Luigi

2011-10-01

The degeneration of three of four meiotic products is a very common process in the female gender of oogamous eukaryotes. In Tillandsia (and many other angiosperms), the surviving megaspore has a callose-free wall in chalazal position while the other three megaspores are completely embedded in callose. Therefore, nutrients and signals can reach more easily the functional megaspore from the nucellus through the chalazal pole with respect to the other megaspores. The abortion of three of four megaspores was already recognized as the result of a programmed cell death (PCD) process. We investigated the process to understand the modality of this specific type of PCD and its relationship to the asymmetric callose deposition around the tetrad. The decision on which of the four megaspores will be the supernumerary megaspores in angiosperms, and hence destined to undergo programmed cell death, appears to be linked to the callose layer deposition around the tetrad. During supernumerary megaspores degeneration, events leading to the deletion of the cells do not appear to belong to a single type of cell death. The first morphological signs are typical of autophagy, including the formation of autophagosomes. The TUNEL positivity and a change in morphology of mitochondria and chloroplasts indicate the passage to an apoptotic-like PCD phase, while the cellular remnants undergo a final process resembling at least partially (ER swelling) necrotic morphological syndromes, eventually leading to a mainly lipidic cell corpse still separated from the functional megaspore by a callose layer.

Time to foster a rational approach to preventing cardiovascular morbid events.

PubMed

Cohn, Jay N; Duprez, Daniel A

2008-07-29

Efforts to prevent atherosclerotic morbid events have focused primarily on risk factor prevention and intervention. These approaches, based on the statistical association of risk factors with events, have dominated clinical practice in the last generation. Because the cardiovascular abnormalities eventuating in morbid events are detectable in the arteries and heart before the development of symptomatic disease, recent efforts have focused on identifying the presence of these abnormalities as a more sensitive and specific guide to the need for therapy. Advances in noninvasive techniques for studying the vasculature and the left ventricle now provide the opportunity to use early disease rather than risk factors as the tool for clinical decision making. A disease scoring system has been developed using 10 tests of vascular and cardiac function and structure. More extensive data to confirm the sensitivity and specificity of this scoring system and to demonstrate its utility in tracking the response to therapy are needed to justify widespread application in clinical practice.

The emergence of different polarity photospheric flux as the cause of CMEs and interplanetary shocks

NASA Technical Reports Server (NTRS)

Bravo, S.

1995-01-01

Here we discuss the effect that the emergence of flux with a polarity opposed to that previously established in a certain photospheric region. can have on the magnetic structure of the solar atmosphere. We show that such a flux emergence may lead to the ejection of coronal material into the interplanetary medium (a CME) and also to a rapid change in the velocity of the solar wind from the region, which may eventually lead to the formation of an interplanetary shock.

Importance of Pipe Deposits to Lead and Copper Rule Compliance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schock, Michael R.; Cantor, Abigail F.; Triantafyllidou, Simoni

When Madison, Wis., exceeded the lead action level in 1992, residential and off-line tests suggested that lead release into the water was more complex than a lead solubility mechanism. Scale analyses (color and texture as well as mineralogical and elemental composition) of five excavated lead service lines (LSLs) revealed that accumulation of manganese (and iron) onto pipe walls had implications for lead corrosion by providing a high-capacity sink for lead. Manganese that accumulated from source well water onto pipe scales (up to 10% by weight of scale composition) served to capture and eventually transport lead to consumer taps. In addition,more » manganese sometimes obstructed the predominance of an insoluble (and thus potentially protective) plattnerite [Pb(IV) solid] scale layer. Full LSL replacement in Madison achieved Lead and Copper Rule compliance and a major reduction in lead contamination and exposure, supplemented by unidirectional flushing of water mains and manganese control in the source well water.« less

Formation of Cosmic Carbon Dust Analogues in Plasma Reactors

NASA Technical Reports Server (NTRS)

Salama, Farid

2016-01-01

Cosmic carbon dust analogs are produced, processed and analyzed in the laboratory using NASA's COSmIC (COSmIC Simulation Chamber) Facility. These experiments can be used to derive information on the most efficient molecular precursors in the chemical pathways that eventually lead to the formation of carbonaceous grains in the stellar envelopes of carbon stars.

Climatic variability of near-surface turbulent kinetic energy over the United States: implications for fire-weather predications

Treesearch

Warren E. Heilman; Xindi Bain

2013-01-01

Recent research suggests that high levels of ambient near-surface atmospheric turbulence are often associated with rapid and sometimes erratic wildland fire spread that may eventually lead to large burn areas. Previous research has also examined the feasibility of using near-surface atmospheric turbulent kinetic energy (TKEs) alone or in...

Modernizing the State Education Agency: Different Paths toward Performance Management

ERIC Educational Resources Information Center

Murphy, Patrick; Rainey, Lydia

2012-01-01

This project examines how eight state education agencies engaged the charge of improving their lowest-performing schools. The states examined are among the most active and intentional in this regard. In many ways, they are at the leading edge of what could eventually become 50 different experiments in performance management. By focusing on states…

Stepping into America: An Educator's Journey to the Intersection of Special Education and the Arts

ERIC Educational Resources Information Center

Cruz, Jesl Xena Rae

2009-01-01

The author came to America to learn more, not just about special education, but about the importance of nurturing one's love for the quest of discoveries that constantly lead to other revelations, which eventually give rise to more inquiry questions that bring about reflections generated interpersonally or intrapersonally. In this article, the…

Good or Bad, What Teachers Expect from Students They Generally Get! ERIC Digest.

ERIC Educational Resources Information Center

Tauber, Robert T.

Research suggests that teacher expectations can predict changes in student achievement and behavior. This Digest discusses the Pygmalion effect, or the idea that one's expectations about a person can eventually lead that person to behave and achieve in ways that conform to those expectations. Many teachers believe that they can judge ahead of time…

James Wardrop and equine recurrent uveitis.

PubMed

Paglia, Danielle T; Miller, Paul E; Dubielzig, Richard R

2004-08-01

James Wardrop should be remembered not only as one of the founders of ocular pathology but also for his contributions to the field of comparative ophthalmology. He described a "specific inflammation" that veterinarians today know as equine recurrent uveitis. As described by Wardrop in the 19th century, this condition is known today to eventually lead to blindness.

Asian Longhorned Beetle - A New Introduction, Pest Alert

Treesearch

USDA Forest Service, State and Private Forestry, Northeastern Area; Animal and Plant Health Inspection Service

2008-01-01

The Asian longhorned beetle (ALB) has been discovered attacking trees in the United States. Tunneling by beetle larvae girdles tree stems and branches. Repeated attacks lead to dieback of the tree crown and, eventually, death of the tree. ALB probably traveled to the United States inside solid wood packing material from China. The beetle has been intercepted at ports...

Then and Now: Fundraising during a Fiscal Crisis--Lessons from the 19th Century

ERIC Educational Resources Information Center

Muscatelli, Anton; Mackay, Francesca

2011-01-01

A housing and municipal construction bubble popped and generated a lending crisis in which interbank lending rates became impossibly high. The banking crisis, which spread across Europe and the United States, eventually impacted other industries, leading to a stock market crash and an economic contraction lasting several years. This was not in…

E-selectin ligand-1 controls circulating prostate cancer cell rolling/adhesion and metastasis

PubMed Central

Yasmin-Karim, Sayeda; King, Michael R.; Messing, Edward M.; Lee, Yi-Fen

2014-01-01

Circulating prostate cancer (PCa) cells preferentially roll and adhere on bone marrow vascular endothelial cells, where abundant E-selectin and stromal cell-derived factor 1 (SDF-1) are expressed, subsequently initiating a cascade of activation events that eventually lead to the development of metastases. To elucidate the roles of circulating PCa cells' rolling and adhesion behaviors in cancer metastases, we applied a dynamic cylindrical flow-based microchannel device that is coated with E-selectin and SDF-1, mimicking capillary endothelium. Using this device we captured a small fraction of rolling PCa cells. These rolling cells display higher static adhesion ability, more aggressive cancer phenotypes and stem-like properties. Importantly, mice received rolling PCa cells, but not floating PCa cells, developed cancer metastases. Genes coding for E-selectin ligands and genes associated with cancer stem cells and metastasis were elevated in rolling PCa cells. Knock down of E-selectin ligand 1(ESL-1), significantly impaired PCa cells' rolling capacity and reduced cancer aggressiveness. Moreover, ESL-1 activates RAS and MAP kinase signal cascade, consequently inducing the downstream targets. In summary, circulating PCa cells' rolling capacity contributes to PCa metastasis, and that is in part controlled by ESL-1. PMID:25301730

Transient Hypothyroidism after Radioiodine for Graves’ Disease: Challenges in Interpreting Thyroid Function Tests

PubMed Central

Sheehan, Michael T.; Doi, Suhail A.R.

2016-01-01

Graves’ disease is the most common cause of hyperthyroidism and is often managed with radioactive iodine (RAI) therapy. With current dosing schemes, the vast majority of patients develop permanent post-RAI hypothyroidism and are placed on life-long levothyroxine therapy. This hypothyroidism typically occurs within the first 3 to 6 months after RAI therapy is administered. Indeed, patients are typically told to expect life-long thyroid hormone replacement therapy to be required within this timeframe and many providers expect this post-RAI hypothyroidism to be complete and permanent. There is, however, a small subset of patients in whom a transient post-RAI hypothyroidism develops which, initially, presents exactly as the typical permanent hypothyroidism. In some cases the transient hypothyroidism leads to a period of euthyroidism of variable duration eventually progressing to permanent hypothyroidism. In others, persistent hyperthyroidism requires a second dose of RAI. Failure to appreciate and recognize the possibility of transient post-RAI hypothyroidism can delay optimal and appropriate treatment of the patient. We herein describe five cases of transient post-RAI hypothyroidism which highlight this unusual sequence of events. Increased awareness of this possible outcome after RAI for Graves’ disease will help in the timely management of patients. PMID:26864507

A Waking Review: Old and Novel Insights into the Spore Germination in Streptomyces.

PubMed

Bobek, Jan; Šmídová, Klára; Čihák, Matouš

2017-01-01

The complex development undergone by Streptomyces encompasses transitions from vegetative mycelial forms to reproductive aerial hyphae that differentiate into chains of single-celled spores. Whereas their mycelial life - connected with spore formation and antibiotic production - is deeply investigated, spore germination as the counterpoint in their life cycle has received much less attention. Still, germination represents a system of transformation from metabolic zero point to a new living lap. There are several aspects of germination that may attract our attention: (1) Dormant spores are strikingly well-prepared for the future metabolic restart; they possess stable transcriptome, hydrolytic enzymes, chaperones, and other required macromolecules stabilized in a trehalose milieu; (2) Germination itself is a specific sequence of events leading to a complete morphological remodeling that include spore swelling, cell wall reconstruction, and eventually germ tube emergences; (3) Still not fully unveiled are the strategies that enable the process, including a single cell's signal transduction and gene expression control, as well as intercellular communication and the probability of germination across the whole population. This review summarizes our current knowledge about the germination process in Streptomyces , while focusing on the aforementioned points.

Death ends a life not a relationship: timework and ritualizations at Mindet.dk

NASA Astrophysics Data System (ADS)

Refslund christensen, Dorthe; Sandvik, Kjetil

2015-04-01

When parents are expecting, the child is usually awaited with hope and plans and reflections on how to share the life and future with this new child. As such the child opens the parents' perspective to a new future, a span of time or potentiality, a certain narrative-that is, being parents, raising a child. When a child is stillborn or dies at a very young age, this event not only turns off all hopes for this particular child, but also all good things envisioned for the child and his or her family, the world itself changes radically. At the Danish website Mindet.dk, parents engage in ritualizations through which they resituate themselves in the world through performing their grief and loss, re-relating themselves to others and renewing their acquaintance with themselves and the world. These ritualizations are carried out through narratives and performances dealing with different aspects of the loss and are not about "translating" the everyday experience into, for instance, a religious realm. Rather "the work of ritual … involves developing repertoires that operate in complex interplay with the world of everyday experience" and, eventually, through time and repetition, lead to re-experiencing life.

Logarithmic Compression of Sensory Signals within the Dendritic Tree of a Collision-Sensitive Neuron

PubMed Central

2012-01-01

Neurons in a variety of species, both vertebrate and invertebrate, encode the kinematics of objects approaching on a collision course through a time-varying firing rate profile that initially increases, then peaks, and eventually decays as collision becomes imminent. In this temporal profile, the peak firing rate signals when the approaching object's subtended size reaches an angular threshold, an event which has been related to the timing of escape behaviors. In a locust neuron called the lobula giant motion detector (LGMD), the biophysical basis of this angular threshold computation relies on a multiplicative combination of the object's angular size and speed, achieved through a logarithmic-exponential transform. To understand how this transform is implemented, we modeled the encoding of angular velocity along the pathway leading to the LGMD based on the experimentally determined activation pattern of its presynaptic neurons. These simulations show that the logarithmic transform of angular speed occurs between the synaptic conductances activated by the approaching object onto the LGMD's dendritic tree and its membrane potential at the spike initiation zone. Thus, we demonstrate an example of how a single neuron's dendritic tree implements a mathematical step in a neural computation important for natural behavior. PMID:22492048

Erosion and sedimentation during the September 2015 flooding of the Kinu River, central Japan.

PubMed

Dan Matsumoto; Sawai, Yuki; Yamada, Masaki; Namegaya, Yuichi; Shinozaki, Tetsuya; Takeda, Daisuke; Fujino, Shigehiro; Tanigawa, Koichiro; Nakamura, Atsunori; Pilarczyk, Jessica E

2016-09-28

Erosional and sedimentary features associated with flooding have been documented in both modern and past cases. However, only a few studies have demonstrated the relationship between these features and the corresponding hydraulic conditions that produced them, making it difficult to evaluate the magnitude of paleo-flooding. This study describes the characteristics associated with inundation depth and flow direction, as well as the erosional and sedimentary features resulting from the disastrous flooding of the Kinu River, central Japan, in September 2015. Water levels rose rapidly due to heavy rainfall that eventually overtopped, and subsequently breached, a levee in Joso City, causing destructive flooding on the surrounding floodplain. Distinctive erosional features are found next to the breached levee, while depositional features, such as a sandy crevasse-splay deposit are found further away from the breach. The deposit can be divided into three units based on sedimentary facies. The vertical and lateral changes of these sedimentary facies may be the result of temporal and spatial changes associated with flow during the single flooding event. These observations and quantitative data provide information that can be used to reveal the paleohydrology of flood deposits in the stratigraphic record, leading to improved mitigation of future flooding disasters.

LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes

PubMed Central

Peschel, Andrea; Langer, Brigitte; Gröger, Marion; Rees, Andrew; Kain, Renate

2016-01-01

ABSTRACT Autophagy is an evolutionarily conserved process used for removing surplus and damaged proteins and organelles from the cytoplasm. The unwanted material is incorporated into autophagosomes that eventually fuse with lysosomes, leading to the degradation of their cargo. The fusion event is mediated by the interaction between the Qa-SNARE syntaxin-17 (STX17) on autophagosomes and the R-SNARE VAMP8 on lysosomes. Cells deficient in lysosome membrane-associated protein-2 (LAMP-2) have increased numbers of autophagosomes but the underlying mechanism is poorly understood. By transfecting LAMP-2-deficient and LAMP-1/2­-double-deficient mouse embryonic fibroblasts (MEFs) with a tandem fluorescent-tagged LC3 we observed a failure of fusion between the autophagosomes and the lysosomes that could be rescued by complementation with LAMP-2A. Although we observed no change in expression and localization of VAMP8, its interacting partner STX17 was absent from autophagosomes of LAMP-2-deficient cells. Thus, LAMP-2 is essential for STX17 expression by the autophagosomes and this absence is sufficient to explain their failure to fuse with lysosomes. The results have clear implications for situations associated with a reduction of LAMP-2 expression. PMID:27628032

How cracks are hot and cool: a burning issue for this paper

NASA Astrophysics Data System (ADS)

Toussaint, Renaud; Santucci, Stéphane; Lengliné, Olivier; Maloy, Knut Jorgen; Vincent-Dospital, Tom; Naert-Giuillot, Muriel

2017-04-01

Material failure is accompanied by important heat exchange, with extremely high temperature - thousands of degrees - reached at crack tips. Such temperature may subsequently alter the mechanical properties of stressed solids, and finally facilitate their rupture. Thermal runaway weakening processes could indeed explain stick-slip motions and even be responsible for deep earthquakes. Therefore, to better understand and eventually prevent catastrophic rupture events, it appears crucial to establish an accurate energy budget of fracture propagation from a clear measure of the various energy dissipation sources. In this work, combining analytical calculations and numerical simulations, we directly relate the temperature field around a moving crack tip to the part α of mechanical energy converted into heat. Monitoring the slow crack growth in paper sheets with an infrared camera, we measure a significant fraction α = 12±4%. Besides, we show that (self-generated) heat accumulation could weaken our samples with microfibers combustion, and lead to a fast crack/dynamic failure/ regime. Reference: Toussaint, R., Lengline, O., Santucci, S., Vincent-Dospital, T., Naert-Guillot, M. and Maloy, K.J., How cracks are hot and cool: a burning issue for paper (2016), Soft Matter (12), 5563-5571, DOI: 10.1039/C6SM00615A

Mass-mortality of guillemots (Uria aalge) in the Gulf of Alaska in 1993

USGS Publications Warehouse

Piatt, John F.; van Pelt, Thomas I.

1997-01-01

During the first six months of 1993, about 3500 dead and moribund guillemots (Uria aalge) were observed throughout the northern Gulf of Alaska coast (ca 1800 km range). Mortality peaked during March. Highest numbers were observed in western Prince William Sound and along the south coast of the Kenai Peninsula. Large flocks of live guillemots gathered in nearshore waters, in contrast to most winters when guillemots reside offshore. Most guillemots recovered were extremely emaciated (ca 60% of normal weight) and sub-adult (80%). Based on carcass deposition and persistence experiments, we calculate that about 10 900 birds eventually came ashore on beaches that were surveyed. Even if most birds killed made it to shore, only a fraction of beaches in the Gulf of Alaska were surveyed and we estimate that a minimum total of 120 000 guillemots died. Results of other investigations on potential causes of mortality (biotoxins, pathogens, parasites, metals, etc.) were either negative or inconclusive, and necropsies lead us to believe that starvation was the proximate cause of death. Reduced food availability could have been related to anomalous sea conditions found during the prolonged 1990–1995 El Niño-Southern Oscillation event.

Symbiotic Origin of Aging.

PubMed

Greenberg, Edward F; Vatolin, Sergei

2018-06-01

Normally aging cells are characterized by an unbalanced mitochondrial dynamic skewed toward punctate mitochondria. Genetic and pharmacological manipulation of mitochondrial fission/fusion cycles can contribute to both accelerated and decelerated cellular or organismal aging. In this work, we connect these experimental data with the symbiotic theory of mitochondrial origin to generate new insight into the evolutionary origin of aging. Mitochondria originated from autotrophic α-proteobacteria during an ancient endosymbiotic event early in eukaryote evolution. To expand beyond individual host cells, dividing α-proteobacteria initiated host cell lysis; apoptosis is a product of this original symbiont cell lytic exit program. Over the course of evolution, the host eukaryotic cell attenuated the harmful effect of symbiotic proto-mitochondria, and modern mitochondria are now functionally interdependent with eukaryotic cells; they retain their own circular genomes and independent replication timing. In nondividing differentiated or multipotent eukaryotic cells, intracellular mitochondria undergo repeated fission/fusion cycles, favoring fission as organisms age. The discordance between cellular quiescence and mitochondrial proliferation generates intracellular stress, eventually leading to a gradual decline in host cell performance and age-related pathology. Hence, aging evolved from a conflict between maintenance of a quiescent, nonproliferative state and the evolutionarily conserved propagation program driving the life cycle of former symbiotic organisms: mitochondria.

Neurotic love letters.

PubMed

Tierra, Tatiana De La

2004-01-01

Abstract The intensity of falling in love is expressed through sexual longing and is focused on pleasures of the body. Fresh fruits and vegetables and other elements of nature-wind, birds, foliage-form part of the setting of seduction. Being in love with another woman makes the entire world beautiful. But the lesbian paradise is eventually eclipsed by bitter realities that intrude upon the relationship-the ever-present ex-lover (still in the picture), family ties (with homophobic overtones), business connections (that imperil lesbian economic independence), and issues of commitment and honesty that eventually lead to betrayal and a bittersweet breakup. Based on correspondence originally written in Spanish, "Neurotic Love Letters" is a testament to an unfortunate fact-that all the love and lust between two women cannot always conquer dubious circumstances and harsh realities unique to lesbian relationships.

Correlation between cytomegalovirus infection and Raynaud's phenomenon in lupus nephritis.

PubMed

Stratta, P; Canavese, C; Ciccone, G; Santi, S; Quaglia, M; Ghisetti, V; Marchiaro, G; Barbui, A; Fop, F; Cavallo, R; Piccoli, G

1999-06-01

Relationships between viruses and autoimmune diseases such as systemic lupus erythematosus (SLE) are still elusive. Recent reports demonstrated the association of some viral infections with peculiar clinical events in the general population, such as cytomegalovirus (CMV) with arterial damage and Parvovirus B19 (PV-B19) with hematologic abnormalities. We planned to look for this kind of viral imprinting in SLE, hypothesizing that traces of specific features of some viral infections might be found in some subsets of seropositive SLE patients. In 60 SLE patients recruited at our nephrologic center, serology for CMV, PV-B19, Epstein-Barr virus viral capsid antigen (EBV-VCA), Epstein-Barr nuclear antigen (EBNA) and Epstein-Barr virus early antigen (EBV-EA) was performed. chi2 and ANOVA were employed to compare the frequency and titers of antiviral antibodies in SLE patients with groups of transplant, hemodialysis and blood donor subjects. chi2, Fisher's test, Bonferroni and Scheffe's test were employed to compare the different biochemical/clinical features between seropositive and seronegative SLE patients. Univariate and multivariate analysis (logistic regression models) were employed to evaluate the odds ratio (OR) of different risk factors for vascular events (including Raynaud's phenomenon, deep venous thrombosis) and hematologic abnormalities (including severe anemia, leukopenia and thrombocytopenia). Anti-CMV (82%), anti-PV-B19 (60%), anti-EBV-VCA (92%) and EBV-EA (45%) IgG antibodies were frequent in SLE, with higher prevalence in comparison with the blood donor group and higher titers in comparison with transplant and hemodialysis groups. CMV seropositivity was a highly significant risk factor for Raynaud's phenomenon (OR +alpha in univariate and multivariate analysis = 13.51 using a correction of 0.5 in case of a zero event), but not for venous vascular events (OR = 1.31). An increased though not significant risk factor was found for antiphospholipid antibodies (OR = 2.71, p = 0.19), while the presence of nephrotic syndrome during the follow-up was a significant protective factor (OR = 0.15, p = 0.035). There was no significantly increased OR for PV-B19 seropositivity in cases with severe anemia (OR = 2.09, p = 0. 29). No significant associations were found with the status of EBV reactivation. In conclusion, our results support the hypothesis that viral infection may imprint the course of SLE leading to specific clinical subsets (i.e. CMV and 'vascular' SLE, with more frequent Raynaud's phenomenon and a less frequent typical histological renal picture responsible for nephrotic syndrome). Further prospective studies are justified to validate these correlations, mainly dealing with associations between acute viral infections and vascular events, thus eventually leading to a better understanding of mutual relationships between viruses and SLE.

Gap opening after merger events of 3-Earth-mass protoplanets

NASA Astrophysics Data System (ADS)

Broz, Miroslav; Chrenko, Ondrej

2017-10-01

While several-Earth-mass protoplanets can gain non-negligible eccentricities due to their interactions with the gaseous disk and ongoing pebble accretion (so called hot trail effect; see the contribution of Chrenko et al. 2017 for details), there is a opened pathway for giant-planet core formation by means of close encounters and eventual merging. As soon as a massive (~13 M_E) merger is formed, it seems necessary to account for one additional term in the set of hydrodynamic equations, namely the gas accretion, which may affect subsequent orbital evolution, and eventually change Type-I migration to Type-II. Using similar approximations as Crida and Bitsch (2017), we prolong our previous simulations towards the onset of gap opening.At the same time, we try to address the observability of these events, e.g. by ALMA in its full configuration. Because the disk is still mostly optically thick in the vertical direction (tau =~ 100), it is necessary to properly model the disk atmosphere. In the midplane, the mean-free path of gas molecules is small enough to assure a sufficient thermal contact and equilibrium between the gas and dust. This is no more true far from the midplane and one has to use a non-equilibrium model (e.g. Radmc-3d code) for the description of dust grain temperatures, resulting synthetic image, or emergent spectrum.

Altered cropping pattern and cultural continuation with declined prosperity following abrupt and extreme arid event at ~4,200 yrs BP: Evidence from an Indus archaeological site Khirsara, Gujarat, western India.

PubMed

Pokharia, Anil K; Agnihotri, Rajesh; Sharma, Shalini; Bajpai, Sunil; Nath, Jitendra; Kumaran, R N; Negi, Bipin Chandra

2017-01-01

Archaeological sites hold important clues to complex climate-human relationships of the past. Human settlements in the peripheral zone of Indus culture (Gujarat, western India) are of considerable importance in the assessment of past monsoon-human-subsistence-culture relationships and their survival thresholds against climatic stress exerted by abrupt changes. During the mature phase of Harappan culture between ~4,600-3,900yrsBP, the ~4,100±100yrsBP time slice is widely recognized as one of the major, abrupt arid-events imprinted innumerous well-dated palaeo records. However, the veracity of this dry event has not been established from any archaeological site representing the Indus (Harappan) culture, and issues concerning timing, changes in subsistence pattern, and the likely causes of eventual abandonment (collapse) continue to be debated. Here we show a significant change in crop-pattern (from barley-wheat based agriculture to 'drought-resistant' millet-based crops) at ~4,200 yrs BP, based on abundant macrobotanical remains and C isotopes of soil organic matter (δ13CSOM) in an archaeological site at Khirsara, in the Gujarat state of western India. The crop-change appears to be intentional and was likely used as an adaptation measure in response to deteriorated monsoonal conditions. The ceramic and architectural remains of the site indicate that habitation survived and continued after the ~4,200yrsBP dry climatic phase, but with declined economic prosperity. Switching to millet-based crops initially helped inhabitants to avoid immediate collapse due to climatic stresses, but continued aridity and altered cropping pattern led to a decline in prosperity levels of inhabitants and eventual abandonment of the site at the end of the mature Harappan phase.

Reducing lead in air and preventing childhood exposure near lead smelters: learning from the U.S. experience.

PubMed

Sullivan, Marianne

2015-05-01

Childhood lead exposure and poisoning near primary lead smelters continues in developed and developing countries. In the United States, the problem of lead poisoning in children caused by smelter emissions was first documented in the early 1970s. In 1978, Environmental Protection Agency set National Ambient Air Quality Standards for lead. Attainment of this lead standard in areas near operating lead smelters took twenty to thirty years. Childhood lead exposure and poisoning continued to occur after the lead National Ambient Air Quality Standards were set and before compliance was achieved. This article analyzes and discusses the factors that led to the eventual achievement of the 1978 lead National Ambient Air Quality Standards near primary smelters and the reduction of children's blood lead levels in surrounding communities. Factors such as federal and state regulation, monitoring of emissions, public health activities such as blood lead surveillance and health education, relocation of children, environmental group and community advocacy, and litigation all played a role. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Ice sheet runoff and Dansgaard-Oeschger Cycles

NASA Astrophysics Data System (ADS)

Hewitt, Ian; Wolff, Eric; Fowler, Andrew; Clark, Chris; Evatt, Geoff; Johnson, Helen; Munday, David; Rickaby, Ros; Stokes, Chris

2016-04-01

Many northern hemisphere climate records, particularly those from around the North Atlantic, show a series of rapid climate changes that recurred on centennial to millennial timescales throughout most of the last glacial period. These Dansgaard-Oeschger (D-O) sequences are observed most prominently in Greenland ice cores, although they have a global signature, including an out of phase Antarctic signal. They consist of warming jumps of order 10°C, occurring in typically 40 years, followed generally by a slow cooling (Greenland Interstadial, GI) lasting between a few centuries and a few millennia, and then a final rapid temperature drop into a cold Greenland Stadial (GS) that lasts for a similar period. Most explanations for D-O events call on changes in Atlantic meridional overturning circulation strength, and the majority of such explanations use changes in freshwater delivery from ice sheets as a trigger. Many have relied on large inputs of freshwater from singular events (such as lake outbursts or iceberg armadas) to push the AMOC into its cold state. However the evidence for such events at the right time in each cycle is sparse. Here we investigate mechanisms that would arise from a change in the rate of ice sheet runoff, which would be a natural feedback from each rapid warming or cooling event. Recent work has suggested that AMOC is most easily disrupted by freshwater delivered through the Arctic. We investigate whether the proposed AMOC changes could have occurred as part of a natural oscillation, in which runoff from the Laurentide ice sheet into the Arctic is controlled by temperature around the North Atlantic. The Arctic buffers the salinity changes, but under warm conditions, high runoff eventually leads to water entering the North Atlantic with low enough salinity to switch AMOC into its weaker state. Under the colder conditions now prevailing, the Arctic is starved of runoff, and the salinity rises until a further switch occurs. Contrary to many previous studies, this mechanism does not require large freshwater pulses to the North Atlantic. Instead, steady changes in ice-sheet runoff, driven by the AMOC, lead to a naturally arising oscillator, in which the rapid warmings come about because the Arctic Ocean is starved of freshwater. The changing size of the ice sheets would have affected the magnitude and extent of runoff, and we suggest that this could provide a simple explanation for the absence of the events during interglacials and around the time of glacial maxima. We construct a simple model to investigate whether the timescales and magnitudes would in practice make this a viable mechanism, and we consider other roles that runoff could play. Heinrich events, delivering additional freshwater into the Atlantic during a Greenland stadial, play no direct role in this mechanism, but would serve to delay the switch to faster AMOC.

Recording brain waves at the supermarket: what can we learn from a shopper's brain?

PubMed

Sands, Stephen F; Sands, J Andrew

2012-01-01

Communication and marketing campaigns have traditionally been divided into two lines: above the line (ATL) and below the line (BTL). ATL campaigns refer to communications such as TV, print, and outdoor displays that are intended to reach large audiences. The effects of ATL are inherently difficult to measure; we do not see the direct consequences of viewing an advertisement (i.e., a talking baby giving financial advice) and actual purchase of the product. ATL is intended to indirectly improve the impression of a brand. BTL campaigns refer to promotions and in-store displays and are designed to affect the point-of-purchase behavior. The effects of BTL are easier to measure; we see direct consequences of viewing a display (i.e., “Today Only, Two for the Price of One”) and eventual purchase of the product. BTL is intended to directly improve the impression of a brand. Neuroscience plays an important role in measuring the effects of marketing campaigns. Traditional methods of measurement (such as surveys and interviews) depend on the verbal ability of the consumer to articulate their motivations for purchasing a product. It is well known that participants are poor at introspective reasoning, leading to an eventual purchase that omits emotional elements. Recently, methods normally employed in cognitive neuroscience have been adapted for use in the evaluation of campaign effectiveness. These methods have increased our understanding of factors leading to economic decisions. The application of neuroscience in ATL campaigns is relatively straightforward. Participants view TV commercials, for example, seated in a comfortable setting with minimal movement while electroencephalogram (EEG) measures are monitored. These brain waves reveal cognitive events related to the media. Participants are exposed to a functional magnetic resonance imaging (fMRI) scanner to monitor changes in blood flow in various regions of the brain. Both of these methods are sensitive to underlying cognitive and emotional activity and are complimentary. EEG is more sensitive to time-locked events (i.e., story lines), whereas fMRI is more sensitive to the brain regions involved. The application of neuroscience in BTL campaigns is significantly more difficult to achieve. Participants move unconstrained in a shopping environment while EEG and eye movements are monitored. In this scenario, fMRI is not possible. fMRI can be used with virtual store mock-ups, but it is expensive and seldom used. We have developed a technology that allows for the measurement of EEG in an unobtrusive manner. The intent is to record the brain waves of participants during their day-to-day shopping experience. A miniaturized video recorder, EEG amplifiers, and eye-tracking systems are used. Digital signal processing is employed to remove the substantial artifact generated by eye movements and motion. Eye fixations identify specific viewings of products and displays, and they are used for synchronizing the behavior with EEG response. The location of EEG sources is determined by the use of a source reconstruction software.

Podocyte Depletion in Thin GBM and Alport Syndrome.

PubMed

Wickman, Larysa; Hodgin, Jeffrey B; Wang, Su Q; Afshinnia, Farsad; Kershaw, David; Wiggins, Roger C

2016-01-01

The proximate genetic cause of both Thin GBM and Alport Syndrome (AS) is abnormal α3, 4 and 5 collagen IV chains resulting in abnormal glomerular basement membrane (GBM) structure/function. We previously reported that podocyte detachment rate measured in urine is increased in AS, suggesting that podocyte depletion could play a role in causing progressive loss of kidney function. To test this hypothesis podometric parameters were measured in 26 kidney biopsies from 21 patients aged 2-17 years with a clinic-pathologic diagnosis including both classic Alport Syndrome with thin and thick GBM segments and lamellated lamina densa [n = 15] and Thin GBM cases [n = 6]. Protocol biopsies from deceased donor kidneys were used as age-matched controls. Podocyte depletion was present in AS biopsies prior to detectable histologic abnormalities. No abnormality was detected by light microscopy at <30% podocyte depletion, minor pathologic changes (mesangial expansion and adhesions to Bowman's capsule) were present at 30-50% podocyte depletion, and FSGS was progressively present above 50% podocyte depletion. eGFR did not change measurably until >70% podocyte depletion. Low level proteinuria was an early event at about 25% podocyte depletion and increased in proportion to podocyte depletion. These quantitative data parallel those from model systems where podocyte depletion is the causative event. This result supports a hypothesis that in AS podocyte adherence to the GBM is defective resulting in accelerated podocyte detachment causing progressive podocyte depletion leading to FSGS-like pathologic changes and eventual End Stage Kidney Disease. Early intervention to reduce podocyte depletion is projected to prolong kidney survival in AS.

Nonlinear multiscale interactions and internal dynamics underlying a typical eddy-shedding event at Luzon Strait

NASA Astrophysics Data System (ADS)

Zhao, Yuan-Bing; Liang, X. San; Gan, Jianping

2016-11-01

Eddy-shedding is a highly nonlinear process that presents a major challenge in geophysical fluid dynamics. Using the newly developed localized multiscale energy and vorticity analysis (MS-EVA), this study investigates an observed typical warm eddy-shedding event as the Kuroshio passes the Luzon Strait, in order to gain insight into the underlying internal dynamics. Through multiscale window transform (MWT), it is found that the loop-form Kuroshio intrusion into the South China Sea (SCS) is not a transient feature, but a quasi-equilibrium state of the system. A mesoscale reconstruction reveals that the eddy does not have its origin at the intrusion path, but comes from the Northwest Pacific. It propagates westward, preceded by a cyclonic (cold) eddy, through the Kuroshio into the SCS. As the eddy pair runs across the main current, the cold one weakens and the warm one intensifies through a mixed instability. In its development, another cold eddy is generated to its southeast, which also experiences a mixed instability. It develops rapidly and cuts the warm eddy off the stream. Both the warm and cold eddies then propagate westward in the form of a Rossby wave (first baroclinic mode). As the eddies approach the Dongsha Islands, they experience another baroclinic instability, accompanied by a sudden accumulation of eddy available potential energy. This part of potential energy is converted to eddy kinetic energy through buoyancy conversion, and is afterward transferred back to the large-scale field through inverse cascading, greatly reducing the intensity of the eddy and eventually leading to its demise.

75 FR 8471 - Airworthiness Directives; Airbus Model A340-200 and A340-300 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... condition as: A review of A340 missions has demonstrated that CFM56-5C forward engine mount thrust links... thrust link would reduce the forward engine mounts' structural integrity and could eventually lead to... products. The MCAI states: A review of A340 missions has demonstrated that CFM56-5C forward engine mount...

Foreword

Treesearch

Charles G. Terry Shaw

2010-01-01

It was in June, 1966 when I started working for the tree disease scientists at the Forestry Sciences Laboratory in Moscow, Idaho. That autumn I would start my University course in Forestry which eventually would lead to a long and rewarding career as a Forest Pathologist. But I knew none of that 44 years ago as a lowly paid summer aid hired by the Blister Rust research...

Game Theoretic Approaches to Protect Cyberspace

DTIC Science & Technology

2010-04-20

security problems. 3.1 Definitions Game A description of the strategic interaction between opposing, or co-operating, interests where the con ...that involves probabilistic transitions through several states of the system. The game pro - gresses as a sequence of states. The game begins with a...eventually leads to a discretized model. The reaction functions uniquely minimize the strictly con - vex cost functions. After discretization, this

Electric dipole moments of light nuclei from {chi}EFT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Higa, Renato

I present recent calculations of EDMs of light nuclei using chiral effective field theory techniques. At leading-order, we argue that they can be expressed in terms of six CP-violating low-energy constants. With our expressions, eventual non-zero measurements of EDMs of deuteron, helion, and triton can be combined to disentangle the different sources of CP-violation.

Electric dipole moments of light nuclei from χEFT

NASA Astrophysics Data System (ADS)

Higa, Renato

2013-03-01

I present recent calculations of EDMs of light nuclei using chiral effective field theory techniques. At leading-order, we argue that they can be expressed in terms of six CP-violating low-energy constants. With our expressions, eventual non-zero measurements of EDMs of deuteron, helion, and triton can be combined to disentangle the different sources of CP-violation.

Perceptions of Educators Regarding the Effectiveness of Alternative Programs in a Southern State

ERIC Educational Resources Information Center

Roberson, Lydia

2015-01-01

At-risk students are engaged in dangerous behaviors that lead them to become involved in the juvenile justice system and cause the feeling of low self-worth. This eventually causes at-risk youths to drop out of school and engage in detrimental behaviors that meddle in their academic success. The alternative education program provides these at-risk…

Children with ADHD Symptoms Show Decreased Activity in Ventral Striatum during the Anticipation of Reward, Irrespective of ADHD Diagnosis

ERIC Educational Resources Information Center

van Hulst, Branko M.; de Zeeuw, Patrick; Bos, Dienke J.; Rijks, Yvonne; Neggers, Sebastiaan F. W.; Durston, Sarah

2017-01-01

Background: Changes in reward processing are thought to be involved in the etiology of attention-deficit/hyperactivity disorder (ADHD), as well as other developmental disorders. In addition, different forms of therapy for ADHD rely on reinforcement principles. As such, improved understanding of reward processing in ADHD could eventually lead to…

A study of spaceraft technology and design concepts, volume 1

NASA Technical Reports Server (NTRS)

Zylius, F. A.

1985-01-01

Concepts for advancing the state of the art in the design of unmanned spacecraft, the requirements that gave rise to its configuration, and the programs of technology that are suggested as leading to its eventual development are examined. Particular technology issues discussed include: structures and materials; thermal control; propulsion; electrical power; communications; data management; and guidance, navigation, and control.

A procedure for maintenance of the virulence plasmid (pYV) in Yersinia pestis under culture conditions

USDA-ARS?s Scientific Manuscript database

The pathogenicity of Yersinia pestis depends on the presence of a virulence plasmid (pYV). The unstable nature of pYV in Y. pestis leads to the eventual outgrowth of pYV less cells due to its higher growth rate. Thus, it was necessary to develop procedures to monitor the presence of the plasmid du...

Neuroendocrine modulation and repercussions of female reproductive aging.

PubMed

Wise, Phyllis M; Smith, Matthew J; Dubal, Dena B; Wilson, Melinda E; Rau, Shane W; Cashion, Adrienne B; Böttner, Martina; Rosewell, Katherine L

2002-01-01

The menopause marks the end of a woman's reproductive life. During the postmenopausal period, plasma estrogen concentrations decrease dramatically and remain low for the rest of her life, unless she chooses to take hormone replacement therapy. During the past 20 years, we have learned that changes in the central nervous system are associated with and may influence the timing of the menopause in women. Recently, it has become clear that estrogens act on more than just the hypothalamus, pituitary, ovary, and other reproductive organs. In fact, they play roles in a wide variety of nonreproductive functions. With the increasing life span of humans from approximately 50 to 80 years and the relatively fixed age of the menopause, a larger number of women will spend over one third of their lives in the postmenopausal state. It is not surprising that interest has increased in factors that govern the timing of the menopause and the repercussions of the lack of estrogen on multiple aspects of women's health. We have used animal models to better understand the complex interactions between the ovary and the brain that lead to the menopause and the repercussions of the hypoestrogenic state. Our results show that when rats reach middle age, the patterns and synchrony of multiple neurochemical events that are critical to the preovulatory gonadotropin-releasing hormone (GnRH) surge undergo subtle changes. The precision of rhythmic pattern of neurotransmitter dynamics depends on the presence of estradiol. Responsiveness to this hormone decreases in middle-aged rats. The lack of precision in the coordination in the output of neural signals leads to a delay and attenuation of the luteinizing hormone surge, which lead to irregular estrous cyclicity and, ultimately, to the cessation of reproductive cycles. We also have examined the impact of the lack of estrogen on the vulnerability of the brain to injury. Our work establishes that the absence of estradiol increases the extent of cell death after stroke-like injury and that treatment with low physiological levels of estradiol are profoundly neuroprotective. We have begun to explore the cellular and molecular mechanisms that underlie this novel nonreproductive action of estrogens. In summary, our studies show that age-related changes in the ability of estradiol to coordinate the neuroendocrine events that lead to regular preovulatory GnRH surges contribute to the onset of irregular estrous cycles and eventually to acyclicity. Furthermore, we have shown that the lack of estradiol increases the vulnerability of the brain to injury and neurodegeneration.

Advances in Age-related Macular Degeneration Understanding and Therapy

PubMed Central

Miller, Joan W; Bagheri, Saghar; Vavvas, Demetrios G

2017-01-01

While the development of anti-vascular endothelial growth factor (anti-VEGF) as a therapy for neovascular age-related macular degeneration (AMD) was a great success, the pathologic processes underlying dry AMD that eventually leads to photoreceptor dysfunction, death, and vision loss remain elusive to date, with a lack of effective therapies and increasing prevalence of the disease. There is an overwhelming need to improve the classification system of AMD, to increase our understanding of cell death mechanisms involved in both neovascular and non-neovascular AMD, and to develop better biomarkers and clinical endpoints to eventually be able to identify better therapeutic targets—especially early in the disease process. There is no doubt that it is a matter of time before progress will be made and better therapies will be developed for non-neovascular AMD. PMID:29142592

Reaction Electronic Flux Perspective on the Mechanism of the Zimmerman Di-π-methane Rearrangement.

PubMed

Matute, Ricardo A; Pérez, Patricia; Chamorro, Eduardo; Villegas-Escobar, Nery; Cortés-Arriagada, Diego; Herrera, Barbara; Gutiérrez-Oliva, Soledad; Toro-Labbé, Alejandro

2018-06-01

The reaction electronic flux (REF) offers a powerful tool in the analysis of reaction mechanisms. Noteworthy, the relationship between aromaticity and REF can eventually reveal subtle electronic events associated with reactivity in aromatic systems. In this work, this relationship was studied for the triplet Zimmerman di-π-methane rearrangement. The aromaticity loss and gain taking place during the reaction is well acquainted by the REF, thus shedding light on the electronic nature of reactions involving dibenzobarrelenes.

Korean Affairs Report, KULLOJA, Number 7, July 1985

DTIC Science & Technology

1986-04-09

happy events worthy of special mention in the history of our people’s struggle for the chuche revolutionary cause, our party has energetically appealed ...construction in the coming year." (Book "New Year’s Address," 1985, p 11) Loftily upholding the militant appeal of the party for glorifying the 40th...eventually become unable to observe the partywide principle and in the end, will fall to the ground as a useless snob . In order to make the

KSC-2010-4382

NASA Image and Video Library

2010-08-12

CAPE CANAVERAL, Fla. -- In the Space Station Processing Facility at NASA's Kennedy Space Center in Florida, a robotics engineer animates the dexterous humanoid astronaut helper, Robonaut (R2) for the participants at a media event hosted by NASA. R2 will fly to the International Space Station aboard space shuttle Discovery on the STS-133 mission. Although it will initially only participate in operational tests, upgrades could eventually allow the robot to realize its true purpose -- helping spacewalking astronauts with tasks outside the space station. Photo credit: NASA/Jim Grossmann

Approximations first: a closer look at applications of the definite integral

NASA Astrophysics Data System (ADS)

Brandt, Keith

2017-01-01

I propose that students pay more attention to the approximations that lead to integral formulas when they study applications of the definite integral. The goal is to focus students on the underlying concepts and the definition of the definite integral - and to steer them away from memorizing formulas. To address this goal, I have written some computer-based activities that guide students through the nuts and bolts of the approximations that eventually lead to integral formulas. I describe the activities and suggest a few changes as to how we might approach this material.

Conception of the first magnetic resonance imaging contrast agents: a brief history.

PubMed

de Haën, C

2001-08-01

About 20 years ago, a technological innovation process started that eventually led to the affirmation of magnetic resonance imaging (MRI) contrast agents, which are used today in about 25% of all MRI procedures, as medical diagnostic tools. The process began with exploration of various technical possibilities and the conception in the years 1981 to 1982 of two types of agents (soluble paramagnetic chelates and protection colloid-stabilized colloidal particle solutions of magnetite) that eventually found embodiments in commercially available products. The pioneering products that eventually reached the market were gadopentetate dimeglumine (Magnevist, Schering AG) and the ferumoxides (Endorem, Guerbet SA; or Ferridex , Berlex Laboratories Inc.). The history of the conception phase of the technology is reconstructed here, focusing on the social dynamics rather than on technological aspects. In the period 1981 to 1982, a number of independent inventors from industry and academia conceived of water-soluble paramagnetic chelates and protection colloid-stabilized colloidal solutions of small particles of magnetite, both of acceptable tolerability, as contrast agents for MRI. Priorities on patents conditioned the further course of events. The analyzed history helps in understanding the typical roles of different institutions in technological innovation. The foundation of MRI contrast agent technology in basic science clearly was laid in academia. During the conception of practical products, industry assumed a dominant role. Beginning with the radiological evaluation of candidate products, the collaboration between industry and academia became essential.

Observation of a centrality-dependent dijet asymmetry in lead-lead collisions at sqrt[S(NN)] =2.76 TeV with the ATLAS detector at the LHC.

PubMed

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Zhou, N; Zhou, Y; Zhu, C G; Zhu, H; Zhu, Y; Zhuang, X; Zhuravlov, V; Zieminska, D; Zilka, B; Zimmermann, R; Zimmermann, S; Zimmermann, S; Ziolkowski, M; Zitoun, R; Zivković, L; Zmouchko, V V; Zobernig, G; Zoccoli, A; Zolnierowski, Y; Zsenei, A; zur Nedden, M; Zutshi, V; Zwalinski, L

2010-12-17

By using the ATLAS detector, observations have been made of a centrality-dependent dijet asymmetry in the collisions of lead ions at the Large Hadron Collider. In a sample of lead-lead events with a per-nucleon center of mass energy of 2.76 TeV, selected with a minimum bias trigger, jets are reconstructed in fine-grained, longitudinally segmented electromagnetic and hadronic calorimeters. The transverse energies of dijets in opposite hemispheres are observed to become systematically more unbalanced with increasing event centrality leading to a large number of events which contain highly asymmetric dijets. This is the first observation of an enhancement of events with such large dijet asymmetries, not observed in proton-proton collisions, which may point to an interpretation in terms of strong jet energy loss in a hot, dense medium.

Selection and geographic isolation influence hummingbird speciation: genetic, acoustic and morphological divergence in the wedge-tailed sabrewing (Campylopterus curvipennis).

PubMed

González, Clementina; Ornelas, Juan Francisco; Gutiérrez-Rodríguez, Carla

2011-02-08

Mesoamerica is one of the most threatened biodiversity hotspots in the world, yet we are far from understanding the geologic history and the processes driving population divergence and speciation for most endemic taxa. In species with highly differentiated populations selective and/or neutral factors can induce rapid changes to traits involved in mate choice, promoting reproductive isolation between allopatric populations that can eventually lead to speciation. We present the results of genetic differentiation, and explore drift and selection effects in promoting acoustic and morphological divergence among populations of Campylopterus curvipennis, a lekking hummingbird with an extraordinary vocal variability across Mesoamerica. Analyses of two mitochondrial genes and ten microsatellite loci genotyped for 160 individuals revealed the presence of three lineages with no contemporary gene flow: C. c. curvipennis, C. c. excellens, and C. c. pampa disjunctly distributed in the Sierra Madre Oriental, the Tuxtlas region and the Yucatan Peninsula, respectively. Sequence mtDNA and microsatellite data were congruent with two diversification events: an old vicariance event at the Isthmus of Tehuantepec (c. 1.4 Ma), and a more recent Pleistocene split, isolating populations in the Tuxtlas region. Hummingbirds of the excellens group were larger, and those of the pampa group had shorter bills, and lineages that have been isolated the longest shared fewer syllables and differed in spectral and temporal traits of a shared syllable. Coalescent simulations showed that fixation of song types has occurred faster than expected under neutrality but the null hypothesis that morphological divergence resulted from drift was not rejected. Our phylogeographic analyses uncovered the presence of three Mesoamerican wedge-tailed sabrewing lineages, which diverged at different time scales. These results highlight the importance of the Isthmus of Tehuantepec and more recent Pleistocene climatic events in driving isolation and population divergence. Coalescent analyses of the evolution of phenotypic traits suggest that selection is driving song evolution in wedge-tailed sabrewings but drift could not be rejected as a possibility for morphological divergence.

Technical Challenges for a Comprehensive Test Ban: A historical perspective to frame the future (Invited)

NASA Astrophysics Data System (ADS)

Wallace, T. C.

2013-12-01

In the summer of 1958 scientists from the Soviet block and the US allies met in Geneva to discuss what it would take to monitor a forerunner to a Comprehensive Test Ban Treaty at the 'Conference of Experts to Study the Possibility of Detecting Violations of a Possible Agreement on Suspension of Nuclear Tests'. Although armed with a limited resume of observations, the conference recommended a multi-phenomenology approach (air sampling, acoustics, seismic and electromagnetic) deployed it a network of 170 sites scattered across the Northern Hemisphere, and hypothesized a detection threshold of 1kt for atmospheric tests and 5kt for underground explosions. The conference recommendations spurred vigorous debate, with strong disagreement with the stated detection hypothesis. Nevertheless, the technical challenges posed lead to a very focused effort to improve facilities, methodologies and, most importantly, research and development on event detection, location and identification. In the ensuing 50 years the various challenges arose and were eventually 'solved'; these included quantifying yield determination to enter a Limited Threshold Test Ban, monitoring broad areas of emerging nuclear nations, and after the mid-1990s lowering the global detection threshold to sub-kiloton levels for underground tests. Today there is both an international monitoring regime (ie, the International Monitoring System, or IMS) and a group of countries that have their own national technical means (NTM). The challenges for the international regime are evolving; the IMS has established itself as a very credible monitoring system, but the demand of a CTBT to detect and identify a 'nuclear test' of diminished size (zero yield) poses new technical hurdles. These include signal processing and understanding limits of resolution, location accuracy, integration of heterogeneous data, and accurately characterizing anomalous events. It is possible to extrapolate past technical advances to predict what should be available by 2020; detection of coupled explosions to 100s of tons for all continental areas, as well as a probabilistic assessment of event identification.

Science and Strategic - Climate Implications

NASA Astrophysics Data System (ADS)

Tindall, J. A.; Moran, E. H.

2008-12-01

Energy of weather systems greatly exceeds energy produced and used by humans. Variation in this energy causes climate variability potentially resulting in local, national, and/or global catastrophes beyond our ability to deter the loss of life and economic destabilization. Large scale natural disasters routinely result in shortages of water, disruption of energy supplies, and destruction of infrastructure. The resulting unforeseen and disastrous events occurring beyond national emergency preparation, as related to climate variability, could insight civil unrest due to dwindling and/or inaccessible resources necessary for survival. Lack of these necessary resources in impacted countries often leads to wars. Climate change coupled with population growth, which exposes more of the population to potential risks associated with climate and environmental change, demands faster technological response. Understanding climate/associated environmental changes, the relation to human activity and behavior, and including this in national and international emergency/security management plans would alleviate shortcomings in our present and future technological status. The scale of environmental change will determine the potential magnitude of civil unrest at the local, national, and/or global level along with security issues at each level. Commonly, security issues related to possible civil unrest owing to temporal environmental change is not part of a short and/or long-term strategy, yet recent large-scale disasters are reminders that system failures (as in hurricane Katrina) include acknowledged breaches to individual, community, and infrastructure security. Without advance planning and management concerning environmental change, oncoming and climate related events will intensify the level of devastation and human catastrophe. Depending upon the magnitude and period of catastrophic events and/or environmental changes, destabilization of agricultural systems, energy supplies, and other lines of commodities often results in severely unbalanced supply and demand ratios, which eventually affect the entire global community. National economies potentially risk destabilization, which is especially important since economics plays a major role in strategic planning. This presentation will address these issues and the role that science can play in human sustainability and local, national, and international security.

Colonization and speciation of cave animals in the Philippines

NASA Astrophysics Data System (ADS)

Husana, D.; Yamamuro, M.; Kase, T.

2012-12-01

Island-like situation of caves resulted to species isolation while organism's phenotypic plasticity allows the animal to cope with the cave's environment. These conditions eventually lead to organism's speciation through genetic differentiation. Combined morphological and molecular analyses provided insights on the speciation events and colonization of the subterranean ecosystem. Morphological analysis of hypogean species, known as troglobite, and its epigean congeners showed the interesting differences in their characters. Troglobite exhibited cave adaptations such as degenerated eyesight, enlargement or elongation of ambulatory organs, loss of pigmentation and development of other useful organs that favors their survival in the dark cave environment. Molecular clock estimation based on the substitution rate of 0.88% per million years established for 16S rRNA for the grapsid crab genus Sesarma suggested that the troglobitic Sundathelphusa species colonized the cave habitat in Samar Island in the late Miocene epoch and started to diverge from its epigean ancestor ca. 5.92 mya. Interestingly, the five species of the genus Sundathelphusa from Bohol Island comprising of both hypogean and epigean species (S. cavernicola, S. sottoae, S. vediniki, S. urichi and S. boex) occupy a single clade with divergence time from its sister clade ca. 2.58 mya. This phenomenon suggests two possible interpretations of the existence of Bohol species: (1) they belong to a single species with regular genetic flow from their surface relative and that their character differences can be best interpreted as ecophenotypic, or, (2) the speciation event was very rapid and quite recent. Mitochondrial DNA sequences of 430 base pairs of the large subunit rRNA (16S rRNA) revealed the phylogenetic relationships of the genus Sundathelphusa suggesting a multiple colonizations of caves. The speciation events coincided with the timing of the eustatic sea level fluctuation and geologic changes in the Philippine archipelago. This eustatic event and subsequent geologic changes must have influenced the epigean organisms to migrate and invade the subterranean ecosystem. The bizarre feature of hypogean fauna is the result of many years of evolution due to long confinement in the underground ecosystem.

Three Dimensional Simulation of the Baneberry Nuclear Event

NASA Astrophysics Data System (ADS)

Lomov, Ilya N.; Antoun, Tarabay H.; Wagoner, Jeff; Rambo, John T.

2004-07-01

Baneberry, a 10-kiloton nuclear event, was detonated at a depth of 278 m at the Nevada Test Site on December 18, 1970. Shortly after detonation, radioactive gases emanating from the cavity were released into the atmosphere through a shock-induced fissure near surface ground zero. Extensive geophysical investigations, coupled with a series of 1D and 2D computational studies were used to reconstruct the sequence of events that led to the catastrophic failure. However, the geological profile of the Baneberry site is complex and inherently three-dimensional, which meant that some geological features had to be simplified or ignored in the 2D simulations. This left open the possibility that features unaccounted for in the 2D simulations could have had an important influence on the eventual containment failure of the Baneberry event. This paper presents results from a high-fidelity 3D Baneberry simulation based on the most accurate geologic and geophysical data available. The results are compared with available data, and contrasted against the results of the previous 2D computational studies.

Soliton formation from a noise-like pulse during extreme events in a fibre ring laser

NASA Astrophysics Data System (ADS)

Pottiez, O.; Ibarra-Villalon, H. E.; Bracamontes-Rodriguez, Y.; Minguela-Gallardo, J. A.; Garcia-Sanchez, E.; Lauterio-Cruz, J. P.; Hernandez-Garcia, J. C.; Bello-Jimenez, M.; Kuzin, E. A.

2017-10-01

We study experimentally the interactions between soliton and noise-like pulse (NLP) components in a mode-locked fibre ring laser operating in a hybrid soliton-NLP regime. For proper polarization adjustments, one NLP and multiple packets of solitons coexist in the cavity, at 1530 nm and 1558 nm, respectively. By examining time-domain sequences measured using a 16 GHz real-time oscilloscope, we unveil the process of soliton genesis: they are produced during extreme-intensity episodes affecting the NLP. These extreme events can emerge sporadically, appear in small groups or even form quasi-periodic sequences. Once formed, the wavelength-shifted soliton packet drifts away from the NLP in the dispersive cavity, and eventually vanishes after a variable lifetime. Evidence of the inverse process, through which NLP formation is occasionally seeded by an extreme-intensity event affecting a bunch of solitons, is also provided. The quasi-stationary dynamics described here constitutes an impressive illustration of the connections and interactions between NLPs, extreme events and solitons in passively mode-locked fibre lasers.

Visualizing High-Efficiency HIV Transfer | Center for Cancer Research

Cancer.gov

The Human Immunodeficiency Virus (HIV), the causative agent of Acquired Immunodeficiency Syndrome (AIDS), infects and eventually kills CD4 receptor-expressing T cells, which are critical for proper immune system function. The gp120 protein on the surface of HIV particles is known to bind CD4 and a co-receptor, either CCR5 or CXCR4, leading to fusion of the virus and T cell

Developing teamwork skills in capstone design courses.

PubMed

Goldberg, Jay

2010-01-01

The majority of our biomedical engineering graduates will eventually work in an industry where they will be part of multidisciplinary teams that use the collective skills, expertise, experience, and training of each team member. Diversity within these teams provides different perspectives, opinions, and ways of viewing problems, leading to a larger set of potential solutions. Successful careers require engineers to be able to function on multidisciplinary teams.

Use of an ELISA-based stability assay to examine host genotype, PrP**Sc stability, and incubation time relationships in U.S. livestock prion strains

USDA-ARS?s Scientific Manuscript database

Transmissible spongiform encephalopathies (TSEs) are caused by the misfolding of the cellular prion protein (PrP**C) into a disease-associated version (PrP**Sc) that accumulates in certain tissues, leading to pathological changes in the brain and eventual death. Different strains of TSEs have been d...

Information Control: Preserving the Advantage

DTIC Science & Technology

2015-06-01

sanitary laboratory for US forces to exploit technical solutions with minimal resistance, inevitably leading to potent and promising results on the...parity, eventually forcing decision makers to pursue bilateral and multilateral agreements in space law. See McDougall, 272. 21 James Clay Moltz, The...the discussions of human nature, control, and strategy outlined in Chapter 1. 12 James Clay Moltz, The Politics of Space Security: Strategic Restraint

The Moral Dimension of Teaching, Affectionate Schools and the Student Drop out: The Case Study of a Mountainous Community in Pakistan

ERIC Educational Resources Information Center

Shah, Zeenat; Alam, Sultan; Baig, Sharifullah

2012-01-01

This study explored the perceptions, perspectives and viewpoints of the students about the reasons for turning the schools into uninteresting and unaffectionate places for the students eventually leading to the increased drop out ratio. This qualitative study was conducted in four secondary schools, which provide education to the children in four…

Songs My Student Taught Me: Narrative of an Early Childhood Cello Teacher

ERIC Educational Resources Information Center

Hendricks, Karin S.

2013-01-01

Out of the mouth of babes (and even more nonverbal) has come perhaps the wisest music teacher education I have ever received. In this narrative I share my foibles as a young, over-confident, and naive music instructor who, through a great amount of error, eventually learned the value of letting a child lead his own music learning. Throughout this…

[EBOLA HEMORRHAGIC FEVER; ETIOLOGY, EPIDEMIOLOGY, PATHOGENESIS, AND CLINICAL SYMPTOMS].

PubMed

Zhdanov, K W; Zakharenko, S M; Kovalenko, A N; Semenov, A V; Fusin, A Ya

2015-01-01

The data on the prevalence of disease caused by Ebola virus, biological features of its pathogen, character of the epidemiological process, pathogenesis and clinical symptoms are presented. The disease is characterized by suppression of protective immunological mechanisms and systemic inflammatory reaction accounting for the lesions of vascular endothelium, hemostatic and immune systems. It eventually leads to polyorgan insufficiency and severe shock. Lethality amounts to 50%.

Plan Colombia: The Strategic and Operational Imperatives

DTIC Science & Technology

2001-04-01

through freer markets , and economic integration through free trade agreements leading to an eventual Free Trade Area of the Americas. Both the Clinton...such manifestations of the Colombian state as the judicial system, police, military, roads, schools, medical service, markets , and credit facilities... principles of democratic community—the rule of law, the inviolability of international borders, and the security of the individual and society. Illegal

Methodology Report for Phosgene Model (CGModel)

DTIC Science & Technology

2012-01-01

by hydrolysis and acylation reactions, causing irritation and damaging of pulmonary tissue membranes leading to respiratory failure and eventually...literature search: pulmonary edema. 23 Data. from literature search: pulmonary edema. 24 Data from literature search: dyspnea . . . . . . . 2-5 Data...example, "exposures to 2 ppm for 80 minutes will not cause any irritation but result in pulmonary oedema some 12- 16 hours later" [20. p.l50]. This

Bark and ambrosia beetles and their associated fungi colonizing stressed walnut in Missouri and Indiana

Treesearch

Sharon Reed; James English; Jennifer Juzwik; Matt Ginzel

2013-01-01

Thousand cankers disease (TCD) is a growing threat to black walnut, an economically and ecologically important tree in the eastern US. Trees in the earliest stages of TCD do not display symptoms. In later stages, leaves of the canopy become yellow, wilt, and ultimately die, yet remain attached to their branches. Eventually, all branches in the canopy may die, leading...

A Foundation's Story: The First Seventy-Five Years of the Carnegie Foundation for the Advancement of Teaching.

ERIC Educational Resources Information Center

Piefer, Alan

The history of The Carnegie Foundation for the Advancement of Teaching (CFAT) is traced. Three eras are described: 1905 to 1930, a period of initial creativity and influence; 1930 to 1966, a period of gradual decline, leading eventually to loss of independence and virtual extinction; and 1966 to 1979, a period of revitalization. Originally, CFAT…

A procedure for monitoring the presence of the virulence plasmid (pYV) in Yersinia pestis under culture conditions

USDA-ARS?s Scientific Manuscript database

The pathogenicity of Yersinia pestis depends on the presence of a virulence plasmid (pYV). The unstable nature of pYV in Y. pestis leads to the eventual outgrowth of pYV less cells due its higher growth rate. Thus, it was necessary to develop procedures to monitor the presence of the plasmid durin...

A Continuum Model for Metabolic Gas Exchange in Pear Fruit

PubMed Central

Ho, Q. Tri; Verboven, Pieter; Verlinden, Bert E.; Lammertyn, Jeroen; Vandewalle, Stefan; Nicolaï, Bart M.

2008-01-01

Exchange of O2 and CO2 of plants with their environment is essential for metabolic processes such as photosynthesis and respiration. In some fruits such as pears, which are typically stored under a controlled atmosphere with reduced O2 and increased CO2 levels to extend their commercial storage life, anoxia may occur, eventually leading to physiological disorders. In this manuscript we have developed a mathematical model to predict the internal gas concentrations, including permeation, diffusion, and respiration and fermentation kinetics. Pear fruit has been selected as a case study. The model has been used to perform in silico experiments to evaluate the effect of, for example, fruit size or ambient gas concentration on internal O2 and CO2 levels. The model incorporates the actual shape of the fruit and was solved using fluid dynamics software. Environmental conditions such as temperature and gas composition have a large effect on the internal distribution of oxygen and carbon dioxide in fruit. Also, the fruit size has a considerable effect on local metabolic gas concentrations; hence, depending on the size, local anaerobic conditions may result, which eventually may lead to physiological disorders. The model developed in this manuscript is to our knowledge the most comprehensive model to date to simulate gas exchange in plant tissue. It can be used to evaluate the effect of environmental stresses on fruit via in silico experiments and may lead to commercial applications involving long-term storage of fruit under controlled atmospheres. PMID:18369422

Stress, Allostatic Load, Catecholamines, and Other Neurotransmitters in Neurodegenerative Diseases

PubMed Central

2016-01-01

As populations age, the prevalence of geriatric neurodegenerative diseases will increase. These diseases generally are multifactorial, arising from complex interactions among genes, environment, concurrent morbidities, treatments, and time. This essay provides a concept for the pathogenesis of Lewy body diseases such as Parkinson disease, by considering them in the context of allostasis and allostatic load. Allostasis reflects active, adaptive processes that maintain apparent steady states, via multiple, interacting effectors regulated by homeostatic comparators—“homeostats.” Stress can be defined as a condition or state in which a sensed discrepancy between afferent information and a setpoint for response leads to activation of effectors, reducing the discrepancy. “Allostatic load” refers to the consequences of sustained or repeated activation of mediators of allostasis. From the analogy of an idling car, the revolutions per minute of the engine can be maintained at any of a variety of levels (allostatic states). Just as allostatic load (cumulative wear and tear) reflects design and manufacturing variations, byproducts of combustion, and time, eventually leading to engine breakdown, allostatic load in catecholaminergic neurons might eventually lead to Lewy body diseases. Central to the argument is that catecholaminergic neurons leak vesicular contents into the cytoplasm continuously during life and that catecholamines in the neuronal cytoplasm are autotoxic. These neurons therefore depend on vesicular sequestration to limit autotoxicity of cytosolic transmitter. Parkinson disease might be a disease of the elderly because of allostatic load, which depends on genetic predispositions, environmental exposures, repeated stress-related catecholamine release, and time. PMID:22297542

Stress, Allostatic Load, Catecholamines, and Other Neurotransmitters in Neurodegenerative Diseases

PubMed Central

2017-01-01

As populations age, the prevalence of geriatric neurodegenerative diseases will increase. These diseases generally are multifactorial, arising from complex interactions among genes, environment, concurrent morbidities, treatments, and time. This essay provides a concept for the pathogenesis of Lewy body diseases such as Parkinson disease, by considering them in the context of allostasis and allostatic load. Allostasis reflects active, adaptive processes that maintain apparent steady states, via multiple, interacting effectors regulated by homeostatic comparators—“homeostats.” Stress can be defined as a condition or state in which a sensed discrepancy between afferent information and a setpoint for response leads to activation of effectors, reducing the discrepancy. “Allostatic load” refers to the consequences of sustained or repeated activation of mediators of allostasis. From the analogy of an idling car, the revolutions per minute of the engine can be maintained at any of a variety of levels (allostatic states). Just as allostatic load (cumulative wear and tear) reflects design and manufacturing variations, byproducts of combustion, and time, eventually leading to engine breakdown, allostatic load in catecholaminergic neurons might eventually lead to Lewy body diseases. Central to the argument is that catecholaminergic neurons leak vesicular contents into the cytoplasm continuously during life and that catecholamines in the neuronal cytoplasm are autotoxic. These neurons therefore depend on vesicular sequestration to limit autotoxicity of cytosolic transmitter. Parkinson disease might be a disease of the elderly because of allostatic load, which depends on genetic predispositions, environmental exposures, repeated stress-related catecholamine release, and time. PMID:21615193

Macroevolutionary Immunology: A Role for Immunity in the Diversification of Animal life

PubMed Central

Loker, Eric S.

2012-01-01

An emerging picture of the nature of immune systems across animal phyla reveals both conservatism of some features and the appearance among and within phyla of novel, lineage-specific defense solutions. The latter collectively represent a major and underappreciated form of animal diversity. Factors influencing this macroevolutionary (above the species level) pattern of novelty are considered and include adoption of different life styles, life histories, and body plans; a general advantage of being distinctive with respect to immune defenses; and the responses required to cope with parasites, many of which afflict hosts in a lineage-specific manner. This large-scale pattern of novelty implies that immunological phenomena can affect microevolutionary processes (at the population level within species) that can eventually lead to macroevolutionary events such as speciation, radiations, or extinctions. Immunologically based phenomena play a role in favoring intraspecific diversification, specialization and host specificity of parasites, and mechanisms are discussed whereby this could lead to parasite speciation. Host switching – the acquisition of new host species by parasites – is a major mechanism that drives parasite diversity and is frequently involved in disease emergence. It is also one that can be favored by reductions in immune competence of new hosts. Mechanisms involving immune phenomena favoring intraspecific diversification and speciation of host species are also discussed. A macroevolutionary perspective on immunology is invaluable in today’s world, including the need to study a broader range of species with distinctive immune systems. Many of these species are faced with extinction, another macroevolutionary process influenced by immune phenomena. PMID:22566909

Ocean deoxygenation, the global phosphorus cycle and the possibility of human-caused large-scale ocean anoxia

NASA Astrophysics Data System (ADS)

Watson, Andrew J.; Lenton, Timothy M.; Mills, Benjamin J. W.

2017-08-01

The major biogeochemical cycles that keep the present-day Earth habitable are linked by a network of feedbacks, which has led to a broadly stable chemical composition of the oceans and atmosphere over hundreds of millions of years. This includes the processes that control both the atmospheric and oceanic concentrations of oxygen. However, one notable exception to the generally well-behaved dynamics of this system is the propensity for episodes of ocean anoxia to occur and to persist for 105-106 years, these ocean anoxic events (OAEs) being particularly associated with warm `greenhouse' climates. A powerful mechanism responsible for past OAEs was an increase in phosphorus supply to the oceans, leading to higher ocean productivity and oxygen demand in subsurface water. This can be amplified by positive feedbacks on the nutrient content of the ocean, with low oxygen promoting further release of phosphorus from ocean sediments, leading to a potentially self-sustaining condition of deoxygenation. We use a simple model for phosphorus in the ocean to explore this feedback, and to evaluate the potential for humans to bring on global-scale anoxia by enhancing P supply to the oceans. While this is not an immediate global change concern, it is a future possibility on millennial and longer time scales, when considering both phosphate rock mining and increased chemical weathering due to climate change. Ocean deoxygenation, once begun, may be self-sustaining and eventually could result in long-lasting and unpleasant consequences for the Earth's biosphere. This article is part of the themed issue 'Ocean ventilation and deoxygenation in a warming world'.

Resveratrol inhibits uveal melanoma tumor growth via early mitochondrial dysfunction.

PubMed

van Ginkel, Paul R; Darjatmoko, Soesiawati R; Sareen, Dhruv; Subramanian, Lalita; Bhattacharya, Saswati; Lindstrom, Mary J; Albert, Daniel M; Polans, Arthur S

2008-04-01

To test the efficacy of resveratrol, a nontoxic plant product, in the treatment of uveal melanoma. The effect of oral administration and peritumor injection of resveratrol was tested on tumor growth in two animal models of uveal melanoma. The mechanism of resveratrol action on uveal melanoma cells was studied in vitro in a cell-viability assay: with JC-1 dye, to measure mitochondrial membrane potential; by Western blot analysis, to analyze the cellular redistribution of cytochrome c and Smac/diablo; and in a fluorescence assay with specific substrates, to measure activation of different caspases. Resveratrol treatment inhibited tumor growth in animal models of uveal melanoma. Since oral administration resulted in relatively low bioavailability of resveratrol, the effect of increased local levels was tested by peritumor injection of the drug. This method resulted in tumor cell death and tumor regression. In vitro experiments with multiple uveal melanoma cell lines demonstrate that resveratrol causes a decrease in cell viability, resulting at least in part from an increase in apoptosis through a mitochondrial pathway. An early event in drug action is the direct targeting of mitochondria by resveratrol, which leads to a decrease in mitochondrial membrane potential and the eventual activation of caspase-3. These data suggest that resveratrol can inhibit tumor growth and can induce apoptosis via the intrinsic mitochondrial pathway and that by further increasing bioavailability of resveratrol the potency of the drug can be increased, leading to tumor regression. The nontoxic nature of the drug at levels needed for therapy make resveratrol an attractive candidate for the treatment of uveal melanoma.

Hypertension and Hyperglycemia Synergize to Cause Incipient Renal Tubular Alterations Resulting in Increased NGAL Urinary Excretion in Rats

PubMed Central

Blázquez-Medela, Ana M.; García-Sánchez, Omar; Blanco-Gozalo, Víctor; Quiros, Yaremi; Montero, María J.; Martínez-Salgado, Carlos; López-Novoa, José M.; López-Hernández, Francisco J.

2014-01-01

Background Hypertension and diabetes are the two leading causes of chronic kidney disease (CKD) eventually leading to end stage renal disease (ESRD) and the need of renal replacement therapy. Mortality among CKD and ESRD patients is high, mostly due to cardiovascular events. New early markers of risk are necessary to better anticipate the course of the disease, to detect the renal affection of additive risk factors, and to appropriately handle patients in a pre-emptive and personalized manner. Methods Renal function and NGAL urinary excretion was monitored in rats with spontaneous (SHR) or L-NAME induced hypertension rendered hyperglycemic (or not as controls). Results Combination of hypertension and hyperglycemia (but not each of these factors independently) causes an increased urinary excretion of neutrophil gelatinase-associated lipocalin (NGAL) in the rat, in the absence of signs of renal damage. Increased NGAL excretion is observed in diabetic animals with two independent models of hypertension. Elevated urinary NGAL results from a specific alteration in its tubular handling, rather than from an increase in its renal expression. In fact, when kidneys of hyperglycaemic-hypertensive rats are perfused in situ with Krebs-dextran solution containing exogenous NGAL, they excrete more NGAL in the urine than hypertensive rats. We also show that albuminuria is not capable of detecting the additive effect posed by the coexistence of these two risk factors. Conclusions Our results suggest that accumulation of hypertension and hyperglycemia induces an incipient and quite specific alteration in the tubular handling of NGAL resulting in its increased urinary excretion. PMID:25148248

Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.

PubMed

Blázquez-Medela, Ana M; García-Sánchez, Omar; Blanco-Gozalo, Víctor; Quiros, Yaremi; Montero, María J; Martínez-Salgado, Carlos; López-Novoa, José M; López-Hernández, Francisco J

2014-01-01

Hypertension and diabetes are the two leading causes of chronic kidney disease (CKD) eventually leading to end stage renal disease (ESRD) and the need of renal replacement therapy. Mortality among CKD and ESRD patients is high, mostly due to cardiovascular events. New early markers of risk are necessary to better anticipate the course of the disease, to detect the renal affection of additive risk factors, and to appropriately handle patients in a pre-emptive and personalized manner. Renal function and NGAL urinary excretion was monitored in rats with spontaneous (SHR) or L-NAME induced hypertension rendered hyperglycemic (or not as controls). Combination of hypertension and hyperglycemia (but not each of these factors independently) causes an increased urinary excretion of neutrophil gelatinase-associated lipocalin (NGAL) in the rat, in the absence of signs of renal damage. Increased NGAL excretion is observed in diabetic animals with two independent models of hypertension. Elevated urinary NGAL results from a specific alteration in its tubular handling, rather than from an increase in its renal expression. In fact, when kidneys of hyperglycaemic-hypertensive rats are perfused in situ with Krebs-dextran solution containing exogenous NGAL, they excrete more NGAL in the urine than hypertensive rats. We also show that albuminuria is not capable of detecting the additive effect posed by the coexistence of these two risk factors. Our results suggest that accumulation of hypertension and hyperglycemia induces an incipient and quite specific alteration in the tubular handling of NGAL resulting in its increased urinary excretion.

Interactions between aerosol absorption, thermodynamics, dynamics, and microphysics and their impacts on a multiple-cloud system

NASA Astrophysics Data System (ADS)

Lee, Seoung Soo; Li, Zhanqing; Mok, Jungbin; Ahn, Myoung-Hwan; Kim, Byung-Gon; Choi, Yong-Sang; Jung, Chang-Hoon; Yoo, Hye Lim

2017-12-01

This study investigates how the increasing concentration of black carbon aerosols, which act as radiation absorbers as well as agents for the cloud-particle nucleation, affects stability, dynamics and microphysics in a multiple-cloud system using simulations. Simulations show that despite increases in stability due to increasing concentrations of black carbon aerosols, there are increases in the averaged updraft mass fluxes (over the whole simulation domain and period). This is because aerosol-enhanced evaporative cooling intensifies convergence near the surface. This increase in the intensity of convergence induces an increase in the frequency of updrafts with the low range of speeds, leading to the increase in the averaged updraft mass fluxes. The increase in the frequency of updrafts induces that in the number of condensation entities and this leads to more condensation and cloud liquid that acts to be a source of the accretion of cloud liquid by precipitation. Hence, eventually, there is more accretion that offsets suppressed autoconversion, which results in negligible changes in cumulative precipitation as aerosol concentrations increase. The increase in the frequency of updrafts with the low range of speeds alters the cloud-system organization (represented by cloud-depth spatiotemporal distributions and cloud-cell population) by supporting more low-depth clouds. The altered organization in turn alters precipitation spatiotemporal distributions by generating more weak precipitation events. Aerosol-induced reduction in solar radiation that reaches the surface induces more occurrences of small-value surface heat fluxes, which in turn supports the more low-depth clouds and weak precipitation together with the greater occurrence of low-speed updrafts.

Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or -independent manners.

PubMed

Sarfstein, Rive; Friedman, Yael; Attias-Geva, Zohar; Fishman, Ami; Bruchim, Ilan; Werner, Haim

2013-01-01

Accumulating epidemiological evidence shows that obesity is associated with an increased risk of several types of adult cancers, including endometrial cancer. Chronic hyperinsulinemia, a typical hallmark of diabetes, is one of the leading factors responsible for the obesity-cancer connection. Numerous cellular and circulating factors are involved in the biochemical chain of events leading from hyperinsulinemia and insulin resistance to increased cancer risk and, eventually, tumor development. Metformin is an oral anti-diabetic drug of the biguanide family used for treatment of type 2 diabetes. Recently, metformin was shown to exhibit anti-proliferative effects in ovarian and Type I endometrial cancer, although the mechanisms responsible for this non-classical metformin action remain unclear. The insulin-like growth factors (IGFs) play a prominent role in cancer biology and their mechanisms of action are tightly interconnected with the insulin signaling pathways. Given the cross-talk between the insulin and IGF signaling pathways, the aim of this study was to examine the hypothesis that the anti-proliferative actions of metformin in uterine serous carcinoma (USC) are potentially mediated via suppression of the IGF-I receptor (IGF-IR) pathway. Our results show that metformin interacts with the IGF pathway, and induces apoptosis and inhibition of proliferation and migration of USC cell lines with both wild type and mutant p53. Taken together, our results suggest that metformin therapy could be a novel and attractive therapeutic approach for human USC, a highly aggressive variant of endometrial cancer.

Ab initio vel ex eventu

NASA Astrophysics Data System (ADS)

Thiessen, P. A.; Treder, H.-J.

Der gegenwärtige Stand der physikalischen Erkenntnis, in Sonderheit die Atomistik und die Quantentheorie, ermöglicht (in wohldefinierten Energie-Bereichen) eine ab initio-Berechnung aller physikalischen und chemischen Prozesse und Strukturen. Die Schrödinger-Gleichung erlaubt zusammen mit den Prinzipien der Quantenstatistik (Pauli-Prinzip) aus dem Planckschen Wirkungsquantum h und den atomischen Konstanten die Berechnung aller Energieumsätze, Zeitabläufe etc., die insbesondere die chemische Physik bestimmen. Die Rechenresultate gelten auch quantitativ bis auf die unvermeidliche Stochastik.Die ab initio-Berechnungen korrespondieren einerseits und sind andererseits komplementär zu den auf den Methoden der theoretischen Chemie und der klassischen Thermodynamik beruhenden Ergebnissen ex eventu. Die theoretische Behandlung ab initio führt zu mathematischen Experimenten, die die Laboratoriums-Experimente ergänzen oder auch substituieren.Translated AbstractAb initio vel ex eventuThe present state of physical knowledge, in peculiar atomistic and quantum theory, makes an ab initio calculation of all physical and chemical processes and structures possible (in well defined reaches of energy). The Schrödinger equation together with the principles of quantum statistics (Pauli principle) permits from the Planck and atomistic constants to calculate all exchanges of energy, courses of time, etc. which govern chemical physics. The calculated results are valid even quantitatively apart from the unavoidable stochastics.These ab initio calculations on the one hand correspond and are on the other complimentary to results ex eventu based on the methods of theoretical chemistry and classical thermodynamics. Theoretical treatment ab initio leads to mathematical experiments which add to or even substitute experiments in the laboratory.

Directional Characteristics of Inner Shelf Internal Tides

DTIC Science & Technology

2007-06-01

Figure 18. YD 202-206 Current vector plot of significant events. Significant events include internal tidal bores, solibores, and solitons . The upper...Events (Bores, Solibores, and Solitons ): Upper column leading-edge cross-shore current velocity and cross-shore wind regression. The small ellipse...Significant Events (Bores, Solibores, and Solitons ): Upper column leading-edge along-shore current velocity and along-shore wind regression. The small

Late orogenic processes between Baltica and Siberia cratons during the building of Pangea

NASA Astrophysics Data System (ADS)

Puchkov, V.

2003-04-01

Since the Middle Carboniferous, the territory between the Baltica, Kazakhstania and Siberia plates have been part of the continental crust, the last oceanic crust having by then been subducted. At this time continent-continent collision started and proceeded until the latest epochs of the Paleozoic, forming the Uralide orogen. Two features of this collision standout: 1) The northward movement of the Kazakhstanian block between the Baltica and Siberia plates resulted in a large-scale oroclinal bend of structures in West Siberia, which is well expressed in the magnetic field, as well as in the exposed Kazakhstanian structures, and 2) The orogenic event affected the whole territory between the Baltica and Siberia cratons, including the Kazakhstanian continent. A series of intermontane molasse basins are distributed throughout the orogen and in some places, like Bolshoi Karatau, are affected by Late Paleozoic deformation. Continent-continent collision had ceased by the end of the Permian, and in many places Triassic sediments unconformably overly the orogen. Triassic sedimentary sequences are typically coarse-grained (eventually proluvial), evidencing a new stage of mountain building, though many researchers have attributed this to a superplume event. The reason being the widespread flood basalt eruptions that took place not only between, but also on the cratons under discussion. There is a point of view that the break-up of the supercontinents (e.g., Pangea and Rodinia) was preceded by such a superplume event, passing to formation of linear graben systems and then to oceanic spreading. In the case under discussion, the process was arrested (the West Siberian basin with its grabens is often called a "failed ocean"). There is reason to suspect that the Paleozoic collision that led to formation of the Uralides left an enclosed ocean basin in the North, between the Baltica and Siberia plates. Only in the Early Jurassic, with the advent of the Old Kimmerian collision did it finally close, creating the Paykhoy-Novaya Zemlya foldbelt and reworking the Taymyr system. Paleomagnetic data support the conclusion that this event resulted from a rotation of the Siberian craton and high-amplitude strike-slip movements. Elsewhere in Pangea, the processes leading to its break-up had started by the time of the Old Kimmerian event.

Commercial biotechnology processing on International Space Station

NASA Astrophysics Data System (ADS)

Deuser, Mark S.; Vellinger, John C.; Hardin, Juanita R.; Lewis, Marian L.

1998-01-01

Commercial biotechnology processing in space has the potential to eventually exceed the $35 billion annual worldwide market generated by the current satellite communications industry (Parone 1997). The International Space Station provides the opportunity to conduct long-term, crew-tended biotechnology research in microgravity to establish the foundation for this new commercial biotechnology market. Industry, government, and academia are collaborating to establish the infrastructure needed to catalyze this biotechnology revolution that could eventually lead to production of medical and pharmaceutical products in space. The biotechnology program discussed herein is evidence of this collaborative effort, with industry involvement from Space Hardware Optimization Technology, Inc., government participation through the NASA Commercial Space program, and academic guidance from the Consortium for Materials Development in Space at the University of Alabama in Huntsville. Blending the strengths and resources of each collaborator creates a strong partnership, that offers enormous research and commercial opportunities.

Gamma-jet physics with the electro-magnetic calorimeter in the ALICE experiment at LHC

NASA Astrophysics Data System (ADS)

Bourdaud, G.

2008-05-01

The Electro-Magnetic Calorimeter (EMCal) will be fully installed for the first LHC heavy ion beam in order to improve the ALICE experiment performances in detection of high transverse momentum particles and in particular in reconstruction of γ-jet events. These events appear to be very interesting to probe the strongly interacting matter created in ultra-relativistic heavy ion collisions and the eventual Quark Gluon Plasma (QGP) state. Indeed, they may give information on the degree of medium opacity which induces the jet-quenching phenomenon: measuring the energy of the γ and comparing it to that of the associated jet may provide a unique way to quantify the jet energy loss in the dense matter. The interest of γ-jet studies in the framework of the quark gluon plasma physics will be discussed. A particular highlight will be stressed on the EMCal calorimeter. The detection of the γ-jet events will be then presented using this new ALICE detector.

Orbit selection and its impact on radiation warning architecture for a human mission to Mars.

PubMed

Turner, R E; Levine, J M

1998-01-01

With the recent announcement of the discovery of the possibility of life on Mars, there is renewed interest in Mars missions, perhaps eventually in human missions. Astronauts on such missions are at risk to occasional periods of enhanced high energy particle flux from the sun known as Solar Particle Events. These events can pose a substantial risk to the health of the astronauts and to the on-board electronics. Effective forecast and warning of these events could provide time to take steps to minimize the risk (retreating to a safe haven, shutting down sensitive equipment, etc.) Providing that forecast capability, will require additional monitoring capability. The extent of this architecture is sensitive to the orbit selected for the transfer to and from Mars. This paper looks at the major classes of Mars missions (Conjunction and Opposition) and sub-categories of these classes and draws conclusions on the number of monitoring satellites needed for each, with a goal to reducing total system cost through optimum orbit selection.

Microscopic and Metallurgical Aspects of the Space Shuttle Columbia Accident Investigation and Reconstruction

NASA Technical Reports Server (NTRS)

McDaniels, Steven J.

2004-01-01

The Space Shuttle Columbia was descending for a landing at the Kennedy Space Center (KSC) on February 1, 2003. Approximately 20 minutes prior to touchdown, the Columbia began disintegrating over the western United States; the majority of debris eventually impacted in eastern Texas and western Louisiana. A monumental effort eventually recovered approximately 84,000 pieces of debris, approximately 38% of the Orbiter's original dry weight. The debris was transported to KSC, where the items were catalogued and evaluated. Critical areas of interest, such as the left and right leading edge surfaces and the underside of the ship, were placed upon a grid to aid in the reconstruction. Items of interest included metallic structures, reinforced carbon-carbon composites, and ceramic heat insulation tiles. Many of the leading edge elements had re-solidified metallic deposits spattered on them. These deposits became known as slag and were one of the main focuses of the investigation. In order to help determine the sequence of events inside the left wing during the accident, the slag's composition, layering order, and directionality of deposition were studied. A myriad of analytical tests were performed in an attempt to ascertain the compositional and depositional characteristics of selected slag deposits, including the ordering of deposited layers within each individual slag deposit harvested. Initially, Scanning Electron Microscopy and Energy Dispersive X-Ray Spectroscopy (SEM/EDX) were performed to quickly characterize the overall composition of individual slag deposits: SEM utilizes a narrowlyfocused high-energy electron beam impinging upon a specimen. The incident beam excites and liberates lower energy secondary electrons, which are detected and analyzed, providing a visual representation of the sample's surface topography. EDX also relies on an incident electron beam, except an EDX unit measures X-ray energies generated by the impinging beam. Each element generates a unique X-ray signature; the EDX detector measures these discreet energies. EDX actually penetrates approximately 2 microns into the bulk of the sample. However, random examination of various portions of slag, coupled with the semiquantitative nature of the SEM/EDX analysis, did not yield convincingly pertinent data. Therefore, X-ray dot mapping was conducted, which provided more understandable data, both in terms of slag layering and composition. An X-ray dot map is generated by performing numerous EDX scans for individual elements, then compiling the scans in a visual representation. Eventually, specimens consisting of not only the slag, but of the adjacent RCC substrate as well were cross-sectioned. X-Ray dot mapping of the materialographicallymounted and -polished cross- sections provided a visual representation of both the layering sequence and compositional characteristics of the slag. Contemporaneously, Electron Spectroscopy for Chemical Analysis/X-Ray Photoelectron Spectroscopy (ESCA/XPS) and powdered X-Ray Diffraction (XRD) were performed to further characterize the deposits and to attempt to identify what, if any, compounds were present. The ESCA/XPS analysis allowed the analyst to "sputter" into the sample with an electron gun, aiding in the identification of the layering sequence. XPS uses photons, rather than electrons, which impinge upon the surface of the sample. XPS measures the electrons emitted from within the first 5 nm of the sample's surface. The XRD measures the scatter angles of incident X-rays; the angle and intensity of scatter depend upon the crystalline structure of the pulverized sample. XRD is considered a qualitative rather than quantitative technique. ESCA/XPS revealed that the final layer to deposit was predominantly carbonaceous. XRD was successful in identifying specific compounds, such as Al 2O3, Al and/or Al3 21SiO47, mullite (3(Al2)O3 -SiO2), and nickel-aluminides. Eventually, Electron MicroProbe Analysis (EMPA) was conducted on the marialographically-prepared cross- sections of selected slag deposits. Microprobe combines SEM and Wavelength Dispersive X-Ray Spectroscopy (WDS), and, like EDX, uses a narrowly-focused high-energy electron beam impinging upon a specimen to elicit, in the case of EPMA, characteristic X-rays with specific wavelengths. This quantitative, analytical tool proved the most useful in determining depositional layering and composition of the slag deposits. This information was utilized in verifying the location of the breach in the left leading edge of the wing of the Columbia.

Toward standardization of slow earthquake catalog -Development of database website-

NASA Astrophysics Data System (ADS)

Kano, M.; Aso, N.; Annoura, S.; Arai, R.; Ito, Y.; Kamaya, N.; Maury, J.; Nakamura, M.; Nishimura, T.; Obana, K.; Sugioka, H.; Takagi, R.; Takahashi, T.; Takeo, A.; Yamashita, Y.; Matsuzawa, T.; Ide, S.; Obara, K.

2017-12-01

Slow earthquakes have now been widely discovered in the world based on the recent development of geodetic and seismic observations. Many researchers detect a wide frequency range of slow earthquakes including low frequency tremors, low frequency earthquakes, very low frequency earthquakes and slow slip events by using various methods. Catalogs of the detected slow earthquakes are open to us in different formats by each referring paper or through a website (e.g., Wech 2010; Idehara et al. 2014). However, we need to download catalogs from different sources, to deal with unformatted catalogs and to understand the characteristics of different catalogs, which may be somewhat complex especially for those who are not familiar with slow earthquakes. In order to standardize slow earthquake catalogs and to make such a complicated work easier, Scientific Research on Innovative Areas "Science of Slow Earthquakes" has been developing a slow earthquake catalog website. In the website, we can plot locations of various slow earthquakes via the Google Maps by compiling a variety of slow earthquake catalogs including slow slip events. This enables us to clearly visualize spatial relations among slow earthquakes at a glance and to compare the regional activities of slow earthquakes or the locations of different catalogs. In addition, we can download catalogs in the unified format and refer the information on each catalog on the single website. Such standardization will make it more convenient for users to utilize the previous achievements and to promote research on slow earthquakes, which eventually leads to collaborations with researchers in various fields and further understanding of the mechanisms, environmental conditions, and underlying physics of slow earthquakes. Furthermore, we expect that the website has a leading role in the international standardization of slow earthquake catalogs. We report the overview of the website and the progress of construction. Acknowledgment: This work is supported by JSPS KAKENHI Grant Numbers JP16H06472, JP16H06473, JP16H06474, JP16H06477 in Scientific Research on Innovative Areas "Science of Slow Earthquakes", and JP15K17743 in Grant-in-Aid for Young Scientists (B).

Snow fracture: From micro-cracking to global failure

NASA Astrophysics Data System (ADS)

Capelli, Achille; Reiweger, Ingrid; Schweizer, Jürg

2017-04-01

Slab avalanches are caused by a crack forming and propagating in a weak layer within the snow cover, which eventually causes the detachment of the overlying cohesive slab. The gradual damage process leading to the nucleation of the initial failure is still not entirely understood. Therefore, we studied the damage process preceding snow failure by analyzing the acoustic emissions (AE) generated by bond failure or micro-cracking. The AE allow studying the ongoing progressive failure in a non-destructive way. We performed fully load-controlled failure experiments on snow samples presenting a weak layer and recorded the generated AE. The size and frequency of the generated AE increased before failure revealing an acceleration of the damage process with increased size and frequency of damage and/or microscopic cracks. The AE energy was power-law distributed and the exponent (b-value) decreased approaching failure. The waiting time followed an exponential distribution with increasing exponential coefficient λ before failure. The decrease of the b-value and the increase of λ correspond to a change in the event distribution statistics indicating a transition from homogeneously distributed uncorrelated damage producing mostly small AE to localized damage, which cause larger correlated events which leads to brittle failure. We observed brittle failure for the fast experiment and a more ductile behavior for the slow experiments. This rate dependence was reflected also in the AE signature. In the slow experiments the b value and λ were almost constant, and the energy rate increase was moderate indicating that the damage process was in a stable state - suggesting the damage and healing processes to be balanced. On a shorter time scale, however, the AE parameters varied indicating that the damage process was not steady but consisted of a sum of small bursts. We assume that the bursts may have been generated by cascades of correlated micro-cracks caused by localization of stresses at a small scale. The healing process may then have prevented the self-organization of this small scale damage and, therefore, the total failure of the sample.

Extreme air pollution events in Hokkaido, Japan, traced back to early snowmelt and large-scale wildfires over East Eurasia: Case studies.

PubMed

Yasunari, Teppei J; Kim, Kyu-Myong; da Silva, Arlindo M; Hayasaki, Masamitsu; Akiyama, Masayuki; Murao, Naoto

2018-04-25

To identify the unusual climate conditions and their connections to air pollutions in a remote area due to wildfires, we examine three anomalous large-scale wildfires in May 2003, April 2008, and July 2014 over East Eurasia, as well as how products of those wildfires reached an urban city, Sapporo, in the northern part of Japan (Hokkaido), significantly affecting the air quality. NASA's MERRA-2 (the Modern-Era Retrospective analysis for Research and Applications, Version 2) aerosol re-analysis data closely reproduced the PM 2.5 variations in Sapporo for the case of smoke arrival in July 2014. Results show that all three cases featured unusually early snowmelt in East Eurasia, accompanied by warmer and drier surface conditions in the months leading to the fires, inducing long-lasting soil dryness and producing climate and environmental conditions conducive to active wildfires. Due to prevailing anomalous synoptic-scale atmospheric motions, smoke from those fires eventually reached a remote area, Hokkaido, and worsened the air quality in Sapporo. In future studies, continuous monitoring of the timing of Eurasian snowmelt and the air quality from the source regions to remote regions, coupled with the analysis of atmospheric and surface conditions, may be essential in more accurately predicting the effects of wildfires on air quality.

Simultaneous knockdown of six non-family genes using a single synthetic RNAi fragment in Arabidopsis thaliana

DOE Office of Scientific and Technical Information (OSTI.GOV)

Czarnecki, Olaf; Bryan, Anthony C.; Jawdy, Sara S.

Genetic engineering of plants that results in successful establishment of new biochemical or regulatory pathways requires stable introduction of one or more genes into the plant genome. It might also be necessary to down-regulate or turn off expression of endogenous genes in order to reduce activity of competing pathways. An established way to knockdown gene expression in plants is expressing a hairpin-RNAi construct, eventually leading to degradation of a specifically targeted mRNA. Knockdown of multiple genes that do not share homologous sequences is still challenging and involves either sophisticated cloning strategies to create vectors with different serial expression constructs ormore » multiple transformation events that is often restricted by a lack of available transformation markers. Synthetic RNAi fragments were assembled in yeast carrying homologous sequences to six or seven non-family genes and introduced into pAGRIKOLA. Transformation of Arabidopsis thaliana and subsequent expression analysis of targeted genes proved efficient knockdown of all target genes. In conclusion, we present a simple and cost-effective method to create constructs to simultaneously knockdown multiple non-family genes or genes that do not share sequence homology. The presented method can be applied in plant and animal synthetic biology as well as traditional plant and animal genetic engineering.« less

Possible involvement of TLRs and hemichannels in stress-induced CNS dysfunction via mastocytes, and glia activation.

PubMed

Aguirre, Adam; Maturana, Carola J; Harcha, Paloma A; Sáez, Juan C

2013-01-01

In the central nervous system (CNS), mastocytes and glial cells (microglia, astrocytes and oligodendrocytes) function as sensors of neuroinflammatory conditions, responding to stress triggers or becoming sensitized to subsequent proinflammatory challenges. The corticotropin-releasing hormone and glucocorticoids are critical players in stress-induced mastocyte degranulation and potentiation of glial inflammatory responses, respectively. Mastocytes and glial cells express different toll-like receptor (TLR) family members, and their activation via proinflammatory molecules can increase the expression of connexin hemichannels and pannexin channels in glial cells. These membrane pores are oligohexamers of the corresponding protein subunits located in the cell surface. They allow ATP release and Ca(2+) influx, which are two important elements of inflammation. Consequently, activated microglia and astrocytes release ATP and glutamate, affecting myelinization, neuronal development, and survival. Binding of ligands to TLRs induces a cascade of intracellular events leading to activation of several transcription factors that regulate the expression of many genes involved in inflammation. During pregnancy, the previous responses promoted by viral infections and other proinflammatory conditions are common and might predispose the offspring to develop psychiatric disorders and neurological diseases. Such disorders could eventually be potentiated by stress and might be part of the etiopathogenesis of CNS dysfunctions including autism spectrum disorders and schizophrenia.

Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma.

PubMed

Matthews, Julie Marie; Bhatt, Shruti; Patricelli, Matthew P; Nomanbhoy, Tyzoon K; Jiang, Xiaoyu; Natkunam, Yasodha; Gentles, Andrew J; Martinez, Ezequiel; Zhu, Daxing; Chapman, Jennifer Rose; Cortizas, Elena; Shyam, Ragini; Chinichian, Shideh; Advani, Ranjana; Tan, Li; Zhang, Jianming; Choi, Hwan Geun; Tibshirani, Robert; Buhrlage, Sara J; Gratzinger, Dita; Verdun, Ramiro; Gray, Nathanael S; Lossos, Izidore S

2016-07-14

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, yet 40% to 50% of patients will eventually succumb to their disease, demonstrating a pressing need for novel therapeutic options. Gene expression profiling has identified messenger RNAs that lead to transformation, but critical events transforming cells are normally executed by kinases. Therefore, we hypothesized that previously unrecognized kinases may contribute to DLBCL pathogenesis. We performed the first comprehensive analysis of global kinase activity in DLBCL, to identify novel therapeutic targets, and discovered that germinal center kinase (GCK) was extensively activated. GCK RNA interference and small molecule inhibition induced cell-cycle arrest and apoptosis in DLBCL cell lines and primary tumors in vitro and decreased the tumor growth rate in vivo, resulting in a significantly extended lifespan of mice bearing DLBCL xenografts. GCK expression was also linked to adverse clinical outcome in a cohort of 151 primary DLBCL patients. These studies demonstrate, for the first time, that GCK is a molecular therapeutic target in DLBCL tumors and that inhibiting GCK may significantly extend DLBCL patient survival. Because the majority of DLBCL tumors (∼80%) exhibit activation of GCK, this therapy may be applicable to most patients. © 2016 by The American Society of Hematology.

Erosion and sedimentation during the September 2015 flooding of the Kinu River, central Japan

PubMed Central

Dan Matsumoto; Sawai, Yuki; Yamada, Masaki; Namegaya, Yuichi; Shinozaki, Tetsuya; Takeda, Daisuke; Fujino, Shigehiro; Tanigawa, Koichiro; Nakamura, Atsunori; Pilarczyk, Jessica E.

2016-01-01

Erosional and sedimentary features associated with flooding have been documented in both modern and past cases. However, only a few studies have demonstrated the relationship between these features and the corresponding hydraulic conditions that produced them, making it difficult to evaluate the magnitude of paleo-flooding. This study describes the characteristics associated with inundation depth and flow direction, as well as the erosional and sedimentary features resulting from the disastrous flooding of the Kinu River, central Japan, in September 2015. Water levels rose rapidly due to heavy rainfall that eventually overtopped, and subsequently breached, a levee in Joso City, causing destructive flooding on the surrounding floodplain. Distinctive erosional features are found next to the breached levee, while depositional features, such as a sandy crevasse-splay deposit are found further away from the breach. The deposit can be divided into three units based on sedimentary facies. The vertical and lateral changes of these sedimentary facies may be the result of temporal and spatial changes associated with flow during the single flooding event. These observations and quantitative data provide information that can be used to reveal the paleohydrology of flood deposits in the stratigraphic record, leading to improved mitigation of future flooding disasters. PMID:27677769

The retinoblastoma tumor suppressor and stem cell biology.

PubMed

Sage, Julien

2012-07-01

Stem cells play a critical role during embryonic development and in the maintenance of homeostasis in adult individuals. A better understanding of stem cell biology, including embryonic and adult stem cells, will allow the scientific community to better comprehend a number of pathologies and possibly design novel approaches to treat patients with a variety of diseases. The retinoblastoma tumor suppressor RB controls the proliferation, differentiation, and survival of cells, and accumulating evidence points to a central role for RB activity in the biology of stem and progenitor cells. In some contexts, loss of RB function in stem or progenitor cells is a key event in the initiation of cancer and determines the subtype of cancer arising from these pluripotent cells by altering their fate. In other cases, RB inactivation is often not sufficient to initiate cancer but may still lead to some stem cell expansion, raising the possibility that strategies aimed at transiently inactivating RB might provide a novel way to expand functional stem cell populations. Future experiments dedicated to better understanding how RB and the RB pathway control a stem cell's decisions to divide, self-renew, or give rise to differentiated progeny may eventually increase our capacity to control these decisions to enhance regeneration or help prevent cancer development.

LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes.

PubMed

Hubert, Virginie; Peschel, Andrea; Langer, Brigitte; Gröger, Marion; Rees, Andrew; Kain, Renate

2016-10-15

Autophagy is an evolutionarily conserved process used for removing surplus and damaged proteins and organelles from the cytoplasm. The unwanted material is incorporated into autophagosomes that eventually fuse with lysosomes, leading to the degradation of their cargo. The fusion event is mediated by the interaction between the Qa-SNARE syntaxin-17 (STX17) on autophagosomes and the R-SNARE VAMP8 on lysosomes. Cells deficient in lysosome membrane-associated protein-2 (LAMP-2) have increased numbers of autophagosomes but the underlying mechanism is poorly understood. By transfecting LAMP-2-deficient and LAMP-1/2--double-deficient mouse embryonic fibroblasts (MEFs) with a tandem fluorescent-tagged LC3 we observed a failure of fusion between the autophagosomes and the lysosomes that could be rescued by complementation with LAMP-2A. Although we observed no change in expression and localization of VAMP8, its interacting partner STX17 was absent from autophagosomes of LAMP-2-deficient cells. Thus, LAMP-2 is essential for STX17 expression by the autophagosomes and this absence is sufficient to explain their failure to fuse with lysosomes. The results have clear implications for situations associated with a reduction of LAMP-2 expression. © 2016. Published by The Company of Biologists Ltd.

The Effect of Haptic Guidance on Learning a Hybrid Rhythmic-Discrete Motor Task.

PubMed

Marchal-Crespo, Laura; Bannwart, Mathias; Riener, Robert; Vallery, Heike

2015-01-01

Bouncing a ball with a racket is a hybrid rhythmic-discrete motor task, combining continuous rhythmic racket movements with discrete impact events. Rhythmicity is exceptionally important in motor learning, because it underlies fundamental movements such as walking. Studies suggested that rhythmic and discrete movements are governed by different control mechanisms at different levels of the Central Nervous System. The aim of this study is to evaluate the effect of fixed/fading haptic guidance on learning to bounce a ball to a desired apex in virtual reality with varying gravity. Changing gravity changes dominance of rhythmic versus discrete control: The higher the value of gravity, the more rhythmic the task; lower values reduce the bouncing frequency and increase dwell times, eventually leading to a repetitive discrete task that requires initiation and termination, resembling target-oriented reaching. Although motor learning in the ball-bouncing task with varying gravity has been studied, the effect of haptic guidance on learning such a hybrid rhythmic-discrete motor task has not been addressed. We performed an experiment with thirty healthy subjects and found that the most effective training condition depended on the degree of rhythmicity: Haptic guidance seems to hamper learning of continuous rhythmic tasks, but it seems to promote learning for repetitive tasks that resemble discrete movements.

Transient Hypothyroidism after Radioiodine for Graves' Disease: Challenges in Interpreting Thyroid Function Tests.

PubMed

Sheehan, Michael T; Doi, Suhail A R

2016-03-01

Graves' disease is the most common cause of hyperthyroidism and is often managed with radioactive iodine (RAI) therapy. With current dosing schemes, the vast majority of patients develop permanent post-RAI hypothyroidism and are placed on life-long levothyroxine therapy. This hypothyroidism typically occurs within the first 3 to 6 months after RAI therapy is administered. Indeed, patients are typically told to expect life-long thyroid hormone replacement therapy to be required within this timeframe and many providers expect this post-RAI hypothyroidism to be complete and permanent. There is, however, a small subset of patients in whom a transient post-RAI hypothyroidism develops which, initially, presents exactly as the typical permanent hypothyroidism. In some cases the transient hypothyroidism leads to a period of euthyroidism of variable duration eventually progressing to permanent hypothyroidism. In others, persistent hyperthyroidism requires a second dose of RAI. Failure to appreciate and recognize the possibility of transient post-RAI hypothyroidism can delay optimal and appropriate treatment of the patient. We herein describe five cases of transient post-RAI hypothyroidism which highlight this unusual sequence of events. Increased awareness of this possible outcome after RAI for Graves' disease will help in the timely management of patients. © 2016 Marshfield Clinic.

Apico-basal forces exerted by apoptotic cells drive epithelium folding.

PubMed

Monier, Bruno; Gettings, Melanie; Gay, Guillaume; Mangeat, Thomas; Schott, Sonia; Guarner, Ana; Suzanne, Magali

2015-02-12

Epithelium folding is a basic morphogenetic event that is essential in transforming simple two-dimensional epithelial sheets into three-dimensional structures in both vertebrates and invertebrates. Folding has been shown to rely on apical constriction. The resulting cell-shape changes depend either on adherens junction basal shift or on a redistribution of myosin II, which could be driven by mechanical signals. Yet the initial cellular mechanisms that trigger and coordinate cell remodelling remain largely unknown. Here we unravel the active role of apoptotic cells in initiating morphogenesis, thus revealing a novel mechanism of epithelium folding. We show that, in a live developing tissue, apoptotic cells exert a transient pulling force upon the apical surface of the epithelium through a highly dynamic apico-basal myosin II cable. The apoptotic cells then induce a non-autonomous increase in tissue tension together with cortical myosin II apical stabilization in the surrounding tissue, eventually resulting in epithelium folding. Together our results, supported by a theoretical biophysical three-dimensional model, identify an apoptotic myosin-II-dependent signal as the initial signal leading to cell reorganization and tissue folding. This work further reveals that, far from being passively eliminated as generally assumed (for example, during digit individualization), apoptotic cells actively influence their surroundings and trigger tissue remodelling through regulation of tissue tension.

The difference between radio-loud and radio-quiet active galaxies

NASA Astrophysics Data System (ADS)

Wilson, A. S.; Colbert, E. J. M.

1995-01-01

The recent development of unified theories of active galactic nuclei (AGNs) has indicated that there are two physically distinct classes of these objects--radio-loud and radio-quiet. Despite differences, the (probable) thermal emissions from the AGNs (continua and lines from X-ray to infrared wavelengths) are quite similar to the two classes of object. We argue that this last result suggests that the black hole masses and mass accretion rates in the two classes are not greatly different, and that the difference between the classes is associated with the spin of the black hole. We assume that the normal process of accretion through a disk does not lead to rapidly spinning holes and propose that galaxies (e.g., spirals) which have not suffered a recent major merger event contain nonrotating or only slowly rotating black holes. When two such galaxies merge, the two black holes are known to form a binary and we assume that they eventually coalesce. The ratio of the number of radio-loud to radio-quiet AGNs at a given thermal (e.g., optical) luminosity is determined by the galaxy merger rate. Comparisons between the predicted and observed radio luminosity functions constrain the efficiencies with which jet power is extracted from the spinning hole and radio emission is produced by the jet.

Simultaneous knockdown of six non-family genes using a single synthetic RNAi fragment in Arabidopsis thaliana

DOE PAGES

Czarnecki, Olaf; Bryan, Anthony C.; Jawdy, Sara S.; ...

2016-02-17

Genetic engineering of plants that results in successful establishment of new biochemical or regulatory pathways requires stable introduction of one or more genes into the plant genome. It might also be necessary to down-regulate or turn off expression of endogenous genes in order to reduce activity of competing pathways. An established way to knockdown gene expression in plants is expressing a hairpin-RNAi construct, eventually leading to degradation of a specifically targeted mRNA. Knockdown of multiple genes that do not share homologous sequences is still challenging and involves either sophisticated cloning strategies to create vectors with different serial expression constructs ormore » multiple transformation events that is often restricted by a lack of available transformation markers. Synthetic RNAi fragments were assembled in yeast carrying homologous sequences to six or seven non-family genes and introduced into pAGRIKOLA. Transformation of Arabidopsis thaliana and subsequent expression analysis of targeted genes proved efficient knockdown of all target genes. In conclusion, we present a simple and cost-effective method to create constructs to simultaneously knockdown multiple non-family genes or genes that do not share sequence homology. The presented method can be applied in plant and animal synthetic biology as well as traditional plant and animal genetic engineering.« less

The role played by stakeholders in the public debate that brought Italy out of the club of nuclear energy producers.

PubMed

Cantone, Marie Claire; Sturloni, Giancarlo; Brunelli, Giancarlo

2007-10-01

In 1964, Italy was the fourth largest world producer of electricity generated by nuclear reactors, second in Europe only to United Kingdom. In subsequent years, various controversial political events contributed towards drastically slowing down the development of the Italian national nuclear program. The 1986 Chernobyl Nuclear Power Plant accident, which caused a public outcry all over Europe, had particularly serious repercussions in Italy. In a controversial referendum, held in November 1987, Italian citizens voted to repeal three laws promoting the installation of nuclear power plants (NPP) on Italian soil and allowing the National Institute for Electrical Energy (ENEL) to participate in the construction of NPP's abroad. This work analyzes the reasons for that decision and the communication strategies of the stakeholders that took part in the public debate on nuclear energy during the weeks following the Chernobyl accident. Drawing from the methodologies used in media studies, a quantitative and qualitative analysis of two leading Italian newspapers was performed. The results reveal that a variety of stakeholders, upholding different values and interests, took part in the debate. There being no tradition of a public dialogue and participation in Italy, the debate was polarized to a "yes/no choice," which eventually caused Italy to abandon the production of nuclear power for civilian use.

The Outflow Pathway: A Tissue With Morphological and Functional Unity.

PubMed

Saccà, Sergio Claudio; Gandolfi, Stefano; Bagnis, Alessandro; Manni, Gianluca; Damonte, Gianluca; Traverso, Carlo Enrico; Izzotti, Alberto

2016-09-01

The trabecular meshwork (TM) plays an important role in high-tension glaucomas. Indeed, the TM is a true organ, through which the aqueous humor flows from the anterior chamber to Schlemm's canal (SC). Until recently, the TM, which is constituted by endothelial-like cells, was described as a kind of passive filter. In reality, it is much more. The cells delineating the structures of the collagen framework of the TM are endowed with a cytoskeleton, and are thus able to change their shape. These cells also have the ability to secrete the extracellular matrix, which expresses proteins and cytokines, and are capable of phagocytosis and autophagy. The cytoskeleton is attached to the nuclear membrane and can, in millionths of a second, send signals to the nucleus in order to alter the expression of genes in an attempt to adapt to biomechanical insult. Oxidative stress, as happens in aging, has a deleterious effect on the TM, leading eventually to cell decay, tissue malfunction, subclinical inflammation, changes in the extracellular matrix and cytoskeleton, altered motility, reduced outflow facility, and (ultimately) increased IOP. TM failure is the most relevant factor in the cascade of events triggering apoptosis in the inner retinal layers, including ganglion cells. J. Cell. Physiol. 231: 1876-1893, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

A diffusion model for the fate of tandem gene duplicates in diploids.

PubMed

O'Hely, Martin

2007-06-01

Suppose one chromosome in one member of a population somehow acquires a duplicate copy of the gene, fully linked to the original gene's locus. Preservation is the event that eventually every chromosome in the population is a descendant of the one which initially carried the duplicate. For a haploid population in which the absence of all copies of the gene is lethal, the probability of preservation has recently been estimated via a diffusion approximation. That approximation is shown to carry over to the case of diploids and arbitrary strong selection against the absence of the gene. The techniques used lead to some new results. In the large population limit, it is shown that the relative probability that descendants of a small number of individuals carrying multiple copies of the gene fix in the population is proportional to the number of copies carried. The probability of preservation is approximated when chromosomes carrying two copies of the gene are subject to additional, fully non-functionalizing mutations, thereby modelling either an additional cost of replicating a longer genome, or a partial duplication of the gene. In the latter case the preservation probability depends only on the mutation rate to null for the duplicated portion of the gene.

Arctic ice cover, ice thickness and tipping points.

PubMed

Wadhams, Peter

2012-02-01

We summarize the latest results on the rapid changes that are occurring to Arctic sea ice thickness and extent, the reasons for them, and the methods being used to monitor the changing ice thickness. Arctic sea ice extent had been shrinking at a relatively modest rate of 3-4% per decade (annually averaged) but after 1996 this speeded up to 10% per decade and in summer 2007 there was a massive collapse of ice extent to a new record minimum of only 4.1 million km(2). Thickness has been falling at a more rapid rate (43% in the 25 years from the early 1970s to late 1990s) with a specially rapid loss of mass from pressure ridges. The summer 2007 event may have arisen from an interaction between the long-term retreat and more rapid thinning rates. We review thickness monitoring techniques that show the greatest promise on different spatial and temporal scales, and for different purposes. We show results from some recent work from submarines, and speculate that the trends towards retreat and thinning will inevitably lead to an eventual loss of all ice in summer, which can be described as a 'tipping point' in that the former situation, of an Arctic covered with mainly multi-year ice, cannot be retrieved.

Mitochondrial dysfunction: a key player in the pathogenesis of cardiovascular diseases linked to air pollution.

PubMed

Boovarahan, Sri Rahavi; Kurian, Gino A

2018-01-18

Air pollution has become an environmental burden with regard to non-communicable diseases, particularly heart disease. It has been reported that air pollution can accelerate the development of heart failure and atrial fibrillation. Air pollutants encompass various particulate matters (PMs), which change the blood composition and heart rate and eventually leads to cardiac failure by triggering atherosclerotic plaque ruptures or by developing irreversible ischemia. A series of major epidemiological and observational studies have established the noxious effect of air pollutants on cardiovascular diseases (CVD), but the underlying molecular mechanisms of its susceptibility and the pathological disease events remain largely elusive and are predicted to be initiated in the cell organelle. The basis of this belief is that mitochondria are one of the major targets of environmental toxicants that can damage mitochondrial morphology, function and its DNA (manifested in non-communicable diseases). In this article, we review the literature related to air pollutants that adversely affect the progression of CVD and that target mitochondrial morphological and functional activities and how mitochondrial DNA (mtDNA) copy number variation, which reflects the airborne oxidant-induced cell damage, correlates with heart failure. We conclude that environmental health assessment should focus on the cellular/circulatory mitochondrial functional copy number status, which can predict the outcome of CVD.

Drosophila cell cycle under arrest: uncapped telomeres plead guilty.

PubMed

Cenci, Giovanni

2009-04-01

Telomeres are specialized structures that protect chromosome ends from degradation and fusion events. In most organisms, telomeres consist of short, repetitive G-rich sequences added to chromosome ends by a reverse transcriptase with an internal RNA template, called telomerase. Specific DNA-binding protein complexes associate with telomeric sequences preventing chromosome ends from being recognized as DNA double strand breaks (DSBs). Telomeres that lose their cap activate the DNA damage response (DDR) likewise DSBs and, if inappropriately repaired, generate telomeric fusions, which eventually lead to genome instability. In Drosophila there is not telomerase, and telomere length is maintained by transposition of three specialized retroelements. However, fly telomeres are protected by multi protein complexes like their yeast and vertebrate counterparts; these complexes bind chromosome ends in a sequence-independent fashion and are required to prevent checkpoint activation and end-to-end fusion. Uncapped Drosophila telomeres elicit a DDR just as dysfunctional human telomeres. Most interestingly, uncapped Drosophila telomeres also activate the spindle assembly checkpoint (SAC) by recruiting the SAC kinase BubR1. BubR1 accumulations at chromosome ends trigger the SAC that inhibits the metaphase-to-anaphase transition. These findings, reviewed here, highlight an intriguing and unsuspected connection between telomeres and cell cycle regulation, providing a clue to understand human telomere function.

KSC-2012-4404

NASA Image and Video Library

2012-08-14

CAPE CANAVERAL, Fla. -- Florida's Lt. Gov. Jennifer Carroll, left, and NASA Commercial Crew Program Manager Ed Mango shake hands at the National Space Club Florida Committee's August luncheon at the Radisson Resort at the Port in Cape Canaveral, Fla. Mango was the event's guest speaker, discussing the innovative steps the agency is taking with industry partners to develop the next U.S. space transportation capability to and from low Earth orbit, which will eventually be available for use by the U.S. government and other commercial customers. To learn more about the Commercial Crew Program, visit www.nasa.gov/commercialcrew. Photo credit: Kim Shiflett NASA's Ground Systems Development and Operations Program is leading the 20-year life-extension project for the crawler. A pair of behemoth machines called crawler-transporters has carried the load of taking rockets and spacecraft to the launch pad for more than 40 years at NASA’s Kennedy Space Center in Florida. Each weighing six and a half million pounds and larger in size than a professional baseball infield, the crawler-transporters are powered by locomotive and large electrical power generator engines. The crawler-transporters will stand ready to keep up the work for the next generation of launch vehicles to lift astronauts into space. For more information, visit http://www.nasa.gov/exploration/systems/ground/index.html Photo credit: NASA/Jim Grossmann

Early release improves long-term growth and development of direct-seeded nuttall oak saplings

Treesearch

James S. Meadows; Robert L. Johnson; Roger M. Krinard

2015-01-01

Early growth of bottomland oaks is typically slow, and many oaks eventually become overtopped by trees of other species. Removal of these larger competitors in a young stand might improve growth of the oaks and lead to more free-to-grow oaks as the stand matures. Release treatments were applied in 1980 to an 11-year-old, direct-seeded Nuttall oak (Quercus texana Buckl...

Atomization of Wall-Bounded Two-Phase Flows (Preprint)

DTIC Science & Technology

2006-11-07

are given in Fig. 2. In the Rayleigh mode hydrodynamic instabilities produced by surface tension cause the jet surface to undulate [16]. Eventually...18], hydrodynamic instabilities [16] or the interaction of vortices in the gas phase [19]. Various mechanisms, discussed in the Atomization...width of the leading edge of the sheet. This regime is analogous to the Rayleigh mode in jets— hydrodynamic instabilities cause the surface of the

A Study of Religious Faith and the Ethical Decision Making Process

DTIC Science & Technology

2007-09-01

Piaget , 1965; and Rest, 1986) leading to the stage models of moral development . Moral development is the change in how people think about ethical...the environment (Coleman & Wilkins, 2004, p. 512). Jean Piaget (1965) showed how young boys developed morally in stages through observing them...decisions” (Kohlberg, 1981, p. 412). Kohlberg continued with his stage development theory to eventually include a Stage 7 (Kohlberg, 1981, p. 310

Logging damage to residual trees following partial cutting in a green ash-sugarberry stand in the Mississippi Delta

Treesearch

James S. Meadows

1993-01-01

Partial cutting in bottomland hardwoods to control stand density and species composition sometimes results in logging damage to the lower bole and/or roots of residual trees. If severe, logging damage may lead to a decline in tree vigor, which may subsequently stimulate the production of epicormic branches, causing a decrease in bole quality and an eventual loss in...

Quantum chaos inside black holes

NASA Astrophysics Data System (ADS)

Addazi, Andrea

2017-06-01

We show how semiclassical black holes can be reinterpreted as an effective geometry, composed of a large ensemble of horizonless naked singularities (eventually smoothed at the Planck scale). We call these new items frizzy-balls, which can be rigorously defined by Euclidean path integral approach. This leads to interesting implications about information paradoxes. We demonstrate that infalling information will chaotically propagate inside this system before going to the full quantum gravity regime (Planck scale).

Logging Damage to Residual Trees Following Partial Cutting in a Green Ash-Sugarberry Stand in the Mississippi Delta

Treesearch

James S. Meadows

1993-01-01

Partial cutting in bottomland hardwoods to control stand density and species composition sometimes results in logging damage to the lower bole and/or roots of residual trees. If severe, logging damage may lead to a decline in tree vigor, which may subsequently stimulate the production of epicormic branches, causing a decrease in bole quality and an eventual loss in...

Discovering the Factors Contributing to the Decline and Mortality of Willow Oaks in the D'Arbonne National Wildlife Refuge, LA.

Treesearch

Theodor D. Leininger

1998-01-01

Since the early 1990's, mature willow oaks (Quercus phellos L.) on certain sites in the D'Arbonne National Wildlife Refuge(DNWR), in northeast Louisiana, have shown crown dieback. The die back is progressive with some trees continuing to decline, eventually leading to death, within one to three years. This condition has caused the Refuge forester to...

Military Planning in the Twentieth Century

DTIC Science & Technology

1986-01-01

Mehr sein als scheinen” (be more than you appear to be) was his principal motto. Single-mindedness that critics have at times labeled obsessiveness...interviewing nearly a hundred leading figures of the World War I era, the Schlieffen Plan and the eventuating Marne campaign were major topics of...rehabilitate him as a commander, he remains the chief whipping boy for the disaster of the Marne . Criticisms of Moltke’s generalship focus about

Arsenic, microbes and contaminated aquifers

USGS Publications Warehouse

Oremland, Ronald S.; Stolz, John F.

2005-01-01

The health of tens of millions of people world-wide is at risk from drinking arsenic-contaminated well water. In most cases this arsenic occurs naturally within the sub-surface aquifers, rather than being derived from identifiable point sources of pollution. The mobilization of arsenic into the aqueous phase is the first crucial step in a process that eventually leads to human arsenicosis. Increasing evidence suggests that this is a microbiological phenomenon.

Finding a Vulnerable Spot in HIV’s Armor by Investigating the Structure of HIV | Center for Cancer Research

Cancer.gov

The Human Immunodeficiency Virus (HIV) infects and eventually kills CD4-expressing T cells, which are essential for the immune system to function appropriately. Loss of significant numbers of T cells leads to Acquired Immunodeficiency Syndrome (AIDS), a disease that kills over two million people around the world every year. HIV infection depends on two proteins expressed on

Endosomal sorting complexes required for ESCRTing cells toward death during neurogenesis, neurodevelopment and neurodegeneration.

PubMed

Kaul, Zenia; Chakrabarti, Oishee

2018-03-25

The endosomal sorting complexes required for transport (ESCRT) proteins help in the recognition, sorting and degradation of ubiquitinated cargoes from the cell surface, long-lived proteins or aggregates, and aged organelles present in the cytosol. These proteins take part in the endo-lysosomal system of degradation. The ESCRT proteins also play an integral role in cytokinesis, viral budding and mRNA transport. Many neurodegenerative diseases are caused by toxic accumulation of cargo in the cell, which causes stress and ultimately leads to neuronal death. This accumulation of cargo occurs because of defects in the endo-lysosomal degradative pathway-loss of function of ESCRTs has been implicated in this mechanism. ESCRTs also take part in many survival processes, lack of which can culminate in neuronal cell death. While the role played by the ESCRT proteins in maintaining healthy neurons is known, their role in neurodegenerative diseases is still poorly understood. In this review, we highlight the importance of ESCRTs in maintaining healthy neurons and then suggest how perturbations in many of the survival mechanisms governed by these proteins could eventually lead to cell death; quite often these correlations are not so obviously laid out. Extensive neuronal death eventually culminates in neurodegeneration. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Silicosis and coal workers' pneumoconiosis.

PubMed Central

Castranova, V; Vallyathan, V

2000-01-01

Exposure to coal mine dust and/or crystalline silica results in pneumoconiosis with initiation and progression of pulmonary fibrosis. This review presents characteristics of simple and complicated coal workers' pneumoconiosis (CWP) as well as pathologic indices of acute and chronic silicosis by summarizing results of in vitro, animal, and human investigations. These results support four basic mechanisms in the etiology of CWP and silicosis: a) direct cytotoxicity of coal dust or silica, resulting in lung cell damage, release of lipases and proteases, and eventual lung scarring; b) activation of oxidant production by pulmonary phagocytes, which overwhelms the antioxidant defenses and leads to lipid peroxidation, protein nitrosation, cell injury, and lung scarring; c) activation of mediator release from alveolar macrophages and epithelial cells, which leads to recruitment of polymorphonuclear leukocytes and macrophages, resulting in the production of proinflammatory cytokines and reactive species and in further lung injury and scarring; d) secretion of growth factors from alveolar macrophages and epithelial cells, stimulating fibroblast proliferation and eventual scarring. Results of in vitro and animal studies provide a basis for proposing these mechanisms for the initiation and progression of pneumoconiosis. Data obtained from exposed workers lend support to these mechanisms. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 PMID:10931786

Polynyas and Ice Production Evolution in the Ross Sea (PIPERS)

NASA Astrophysics Data System (ADS)

Ackley, S. F.

2017-12-01

One focus of the PIPERS cruise into the Ross Sea ice cover during April-June 2017 was the Terra Nova Bay (TNB) polynya where joint measurements of air-ice-ocean wave interaction were conducted over twelve days. In Terra Nova Bay, measurements were made in three katabatic wind events each with sustained winds over 35 ms-1 and air temperatures below -15C. Near shore, intense wave fields with wave amplitudes of over 2m and 7-9 sec periods built and large amounts of frazil ice crystals grew. The frazil ice gathered initially into short and narrow plumes that eventually were added laterally to create longer and wider streaks or bands. Breaking waves within these wider streaks were dampened which appeared to enhance the development of pancake ice. Eventually, the open water areas between the streaks sealed off, developing a complete ice cover of 100 percent concentration (80-90 percent pancakes, 20-10 percent frazil) over a wide front (30km). The pancakes continued to grow in diameter and thickness as waves alternately contracted and expanded the ice cover, with the thicker larger floes further diminishing the wave field and lateral motion between pancakes until the initial pancake ice growth ceased. The equilibrium thickness of the ice was 20-30cm in the pancake ice. While the waves had died off however, katabatic wind velocities were sustained and resulted in a wide area of concentrated, rafted, pancake ice that was rapidly advected downstream until the end of the katabatic event. High resolution TerraSar-X radar satellite imagery showed the length of the ice area produced in one single event extended over 300km or ten times the length of the open water area during one polynya event. The TNB polynya is therefore an "ice factory" where frazil ice is manufactured into pancake ice floes that are then pushed out of the assembly area and advected, rafted (and occasionally piled up into "dragon skin" ice), until the katabatic wind dies off at the coastal source.

Constraining the rate of oceanic deoxygenation leading up to a Cretaceous Oceanic Anoxic Event (OAE-2: ~94 Ma)

PubMed Central

Ostrander, Chadlin M.; Owens, Jeremy D.; Nielsen, Sune G.

2017-01-01

The rates of marine deoxygenation leading to Cretaceous Oceanic Anoxic Events are poorly recognized and constrained. If increases in primary productivity are the primary driver of these episodes, progressive oxygen loss from global waters should predate enhanced carbon burial in underlying sediments—the diagnostic Oceanic Anoxic Event relic. Thallium isotope analysis of organic-rich black shales from Demerara Rise across Oceanic Anoxic Event 2 reveals evidence of expanded sediment-water interface deoxygenation ~43 ± 11 thousand years before the globally recognized carbon cycle perturbation. This evidence for rapid oxygen loss leading to an extreme ancient climatic event has timely implications for the modern ocean, which is already experiencing large-scale deoxygenation. PMID:28808684

Erythrocyte ion channels in regulation of apoptosis.

PubMed

Lang, Florian; Birka, Christina; Myssina, Svetlana; Lang, Karl S; Lang, Philipp A; Tanneur, Valerie; Duranton, Christophe; Wieder, Thomas; Huber, Stephan M

2004-01-01

Erythrocytes lack mitochondria and nuclei, key organelles in the regulation of apoptosis. Until recently, erythrocytes were thus not considered subject to this type of cell death. However, exposure of erythrocytes to the Ca2+ ionophore ionomycin was shown to induce cell shrinkage, cell membrane blebbing and breakdown of phosphatidylserine asymmetry with subsequent phosphatidylserine exposure at the cell surface, all typical features of apoptosis. Further studies revealed the participation of ion channels in the regulation of erythrocyte "apoptosis." Osmotic shock, oxidative stress and energy depletion all activate a Ca2(+)-permeable non-selective cation channel in the erythrocyte cell membrane. The subsequent increase of Ca2+ concentration stimulates a scramblase leading to breakdown of cell membrane phosphatidylserine asymmetry and activates Ca2+ sensitive K+ (Gardos) channels leading to KCl loss and (further) cell shrinkage. Phosphatidylserine exposure and cell shrinkage are blunted in the nominal absence of extracellular Ca2+, in the presence of the cation channel inhibitors amiloride or ethylisopropylamiloride, at increased extracellular K+ or in the presence of the Gardos channel inhibitors clotrimazole or charybdotoxin. Thus, increase of cytosolic Ca2+ and cellular loss of K+ participate in the triggering of erythrocyte scramblase. Nevertheless, phosphatidylserine exposure is not completely abrogated in the nominal absence of Ca2+, pointing to additional Ca2(+)-independent pathways. One of those is activation of sphingomyelinase with subsequent formation of ceramide which in turn leads to stimulation of erythrocyte scramblase. The exposure of phosphatidylserine at the extracellular face of the cell membrane stimulates phagocytes to engulf the apoptotic erythrocytes. Thus, sustained activation of the cation channels eventually leads to clearance of affected erythrocytes from peripheral blood. Erythropoietin inhibits the non-selective cation channel and thus interferes with erythrocyte "apoptosis." Susceptibility to scramblase activation is enhanced in thalassemia, sickle cell disease and glucose-6-phosphate dehydrogenase deficiency. Infection with Plasmodium falciparum leads to activation of the cation channel eventually triggering erythrocyte "apoptosis."

Phononic Band Gaps in 2D Quadratic and 3D Cubic Cellular Structures

PubMed Central

Warmuth, Franziska; Körner, Carolin

2015-01-01

The static and dynamic mechanical behaviour of cellular materials can be designed by the architecture of the underlying unit cell. In this paper, the phononic band structure of 2D and 3D cellular structures is investigated. It is shown how the geometry of the unit cell influences the band structure and eventually leads to full band gaps. The mechanism leading to full band gaps is elucidated. Based on this knowledge, a 3D cellular structure with a broad full band gap is identified. Furthermore, the dependence of the width of the gap on the geometry parameters of the unit cell is presented. PMID:28793713

KSC-04pd2127

NASA Image and Video Library

2004-10-12

KENNEDY SPACE CENTER, FLA. - This photo shows the size of the sensors being placed on the wing leading edge of orbiter Discovery. In her hand, United Space Alliance technician Lisa Campbell holds an accelerometer (left), which will eventually be installed on a mounting nut. The sensors are part of the Wing Leading Edge Impact Detection System, a new safety measure added for all future Space Shuttle missions. The system also includes accelerometers that monitor the orbiter's wings for debris impacts during launch and while in orbit. There are 22 temperature sensors and 66 accelerometers on each wing. Sensor data will flow from the wing to the crew compartment, where it will be transmitted to Earth.

KSC-04PD-2127

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. This photo shows the size of the sensors being placed on the wing leading edge of orbiter Discovery. In her hand, United Space Alliance technician Lisa Campbell holds an accelerometer (left), which will eventually be installed on a mounting nut. The sensors are part of the Wing Leading Edge Impact Detection System, a new safety measure added for all future Space Shuttle missions. The system also includes accelerometers that monitor the orbiter's wings for debris impacts during launch and while in orbit. There are 22 temperature sensors and 66 accelerometers on each wing. Sensor data will flow from the wing to the crew compartment, where it will be transmitted to Earth.

The astrochemistry of H+3

NASA Astrophysics Data System (ADS)

Herbst, E.

2000-09-01

The reactions of the molecular ion H3+ are pivotal to the chemistry of dense interstellar clouds. Produced by the cosmic-ray ionizati on of molecular hydrogen, H3+ reacts with a variety of a toms and molecules to produce species that are precursors to many of the detect ed molecules in dense clouds. For example, the reaction of H3+ with atomic O leads, eventually, to the production of water, while the re action with HD leads to the production of a wide variety of deuterated isotopom ers. In this article, the chemistry of H3+ and the produc ts derived from it are discussed in the larger context of interstellar chemistr y.

Building confident organizations by filling buckets, building infrastructures, and shining the flashlight.

PubMed

Kerfoot, Karlene

2005-01-01

Leaders have the ability to create confidence or fear in the organization. Kanter (2004) writes that confidence is the "...sweet spot between arrogance and despair" (p. 8). Overconfidence causes people to overshoot, and to assume they are invulnerable. Under-confidence is just as harmful because it leads to under-investing in people, under-innovating, and eventually leads to the disenfranchisement of staff and poor morale. If we take Kanter's advice, we will build an infrastructure that creates confidence in everyone and the organization. But we will not stop there. We will focus "flashlights" on people and activities that are inspiring to others.

Building confident organizations by filling buckets, building infrastructures, and shining the flashlight.

PubMed

Kerfoot, Karlene

2004-01-01

Leaders have the ability to create confidence or fear in the organization. Kanter (2004) writes that confidence is the "...sweet spot between arrogance and despair" (p. 8). Overconfidence causes people to overshoot, and to assume they are invulnerable. Under-confidence is just as harmful because it leads to under-investing in people, under-innovating, and eventually leads to the disenfranchisement of staff and poor morale. If we take Kanter's advice, we will build an infrastructure that creates confidence in everyone and the organization. But we will not stop there. We will focus "flashlights" on people and activities that are inspiring to others.

Building confident organizations by filling buckets, building infrastructures, and shining the flashlight.

PubMed

Kerfoot, Karlene

2005-04-01

Leaders have the ability to create confidence or fear in the organization. Kanter (2004) writes that confidence is the "...sweet spot between arrogance and despair" (p. 8). Overconfidence causes people to overshoot, and to assume they are invulnerable. Underconfidence is just as harmful because it leads to underinvesting in people, under-innovating, and eventually leads to the disenfranchisement of staff and poor morale. If we take Kanter's advice, we will build an infrastructure that creates confidence in everyone and the organization. But we will not stop there. We will focus "flashlights" on people and activities that are inspiring to others.

Phononic Band Gaps in 2D Quadratic and 3D Cubic Cellular Structures.

PubMed

Warmuth, Franziska; Körner, Carolin

2015-12-02

The static and dynamic mechanical behaviour of cellular materials can be designed by the architecture of the underlying unit cell. In this paper, the phononic band structure of 2D and 3D cellular structures is investigated. It is shown how the geometry of the unit cell influences the band structure and eventually leads to full band gaps. The mechanism leading to full band gaps is elucidated. Based on this knowledge, a 3D cellular structure with a broad full band gap is identified. Furthermore, the dependence of the width of the gap on the geometry parameters of the unit cell is presented.

A Dark Year for Tidal Disruption Events

NASA Astrophysics Data System (ADS)

Guillochon, James; Ramirez-Ruiz, Enrico

2015-08-01

Main-sequence disruptions of stars by supermassive black holes result in the production of an extended, geometrically thin debris stream winding repeatedly around the black hole. In the absence of black hole spin, in-plane relativistic precession causes this stream to intersect with itself after a single winding. In this paper we show that relativistic precessions arising from black hole spin can induce deflections out of the original orbital plane that prevent the stream from self-intersecting even after many windings. This naturally leads to a “dark period” in which the flare is not observable for some time, persisting for up to a dozen orbital periods of the most bound material, which translates to years for disruptions around black holes with masses ˜ {10}7{M}⊙ . When the stream eventually self-intersects, the distance from the black hole and the angle at which this collision occurs determine the rate of energy dissipation. We find that more-massive black holes ({M}{{h}}≳ {10}7{M}⊙ ) tend to have more violent stream self-intersections, resulting in prompt accretion. For these tidal disruption events (TDEs), the accretion rate onto the black hole should still closely follow the original fallback rate after a fixed delay time {t}{delay}, {\\dot{M}}{acc}(t+{t}{delay})={\\dot{M}}{fb}(t). For lower black hole masses ({M}{{h}}≲ {10}6), we find that flares are typically slowed down by about an order of magnitude, resulting in the majority of TDEs being sub-Eddington at peak. This also implies that current searches for TDEs are biased toward prompt flares, with slowed flares likely having been unidentified.

Insights into the Structural Dynamics of Nucleocytoplasmic Transport of tRNA by Exportin-t

PubMed Central

Gupta, Asmita; Kailasam, Senthilkumar; Bansal, Manju

2016-01-01

Exportin-t (Xpot) transports mature 5′- and 3′-end processed tRNA from the nucleus to the cytoplasm by associating with a small G-protein Ran (RAs-related nuclear protein), in the nucleus. The release of tRNA in cytoplasm involves RanGTP hydrolysis. Despite the availability of crystal structures of nuclear and cytosolic forms of Xpot, the molecular details regarding the sequential events leading to tRNA release and subsequent conformational changes occurring in Xpot remain unknown. We have performed a combination of classical all-atom and accelerated molecular dynamics simulations on a set of complexes involving Xpot to study a range of features including conformational flexibility of free and cargo-bound Xpot and functionally critical contacts between Xpot and its cargo. The systems investigated include free Xpot and its different complexes, bound either to Ran (GTP/GDP) or tRNA or both. This approach provided a statistically reliable estimate of structural dynamics of Xpot after cargo release. The mechanistic basis for Xpot opening after cargo release has been explained in terms of dynamic structural hinges, about which neighboring region could be displaced to facilitate the nuclear to cytosolic state transition. Post-RanGTP hydrolysis, a cascade of events including local conformational change in RanGTP and loss of critical contacts at Xpot/tRNA interface suggest factors responsible for eventual release of tRNA. The level of flexibility in different Xpot complexes varied depending on the arrangement of individual HEAT repeats. Current study provides one of the most comprehensive and robust analysis carried out on this protein using molecular dynamics schemes. PMID:27028637

Incidence of pericardial effusion after left atrial appendage closure: The impact of underlying heart rhythm. data from the EWOLUTION study.

PubMed

Schmidt, Boris; Betts, Timothy R; Sievert, Horst; Bergmann, Martin W; Kische, Stephan; Pokushalov, Evgeny; Schmitz, Thomas; Meincke, Felix; Mazzone, Patrizio; Stein, Kenneth M; Ince, Hüseyin; Boersma, Lucas V A

2018-05-03

Pericardial effusion/tamponade (PE/PT) is a rare but serious complication following left atrial appendage closure (LAAC). It may be speculated that LAA contraction during sinus rhythm (SR) exerts mechanical force on the device that eventually leads to PE. We sought to determine the incidence and predictors of PE following LAAC using Watchman with special emphasis on the underlying heart rhythm during implant. From 47 centers in 13 European countries 1020 patients underwent LAAC and data on baseline rhythm were available from 1010 patients (mean age 73 ± 9 years, 60% male, median CHA2DS2-VASc = 4). Data were collected via electronic case report forms. A Cox-proportional hazard model was calculated adjusting for multiple variables: age, gender, number of recaptures and device oversizing. During implant, 41% and 59% of patients were in SR and atrial fibrillation (AF), respectively. PE/PT rate was significantly lower in patients implanted during AF at day 30 post implant (n = 1; 0.2% versus n = 6; 1.5%; p = 0.02). No PE requiring intervention occurred in the AF group compared to 5 events (1.2%) in the SR group (p = 0.01). While univariate analysis identified SR and gender as predictors for PE/tamponade, multivariate analysis only showed a statistical trend for both variables. The overall incidence of PE/PT was very low after LAAC using Watchman. Although SR was not identified as an independent predictor of PE/PT, all events requiring intervention occurred in patients with SR. It may be advisable to perform an extended echocardiographic follow-up in that patient population. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Psychosocial risk factors, pre-motor symptoms and first-time hospitalization with Parkinson's disease: a prospective cohort study.

PubMed

Clark, A J; Ritz, B; Prescott, E; Rod, N H

2013-08-01

Experimental studies support a link between stress and development of parkinsonian symptoms, but prospective population studies are lacking. The aim of the current study is to determine the effects of several psychosocial factors on the risk of Parkinson's disease (PD), as well as to identify potential pre-motor symptoms for PD in a large prospective cohort study. In 1991-1993, a total of 9955 women and men free of PD from the Copenhagen City Heart Study were asked about major life events, economic hardship, social network, impaired sleep and vital exhaustion. The participants were followed for first-time hospitalization with PD in nationwide registers until 2011. Vital exhaustion was associated with a higher risk of PD hospitalization in an exposure-dependent manner (P(trend) = 0.001), with high vs. low vital exhaustion being associated with a hazard ratio of 2.50 [95% confidence interval (CI): 1.28-4.89]. A slightly higher risk of PD hospitalization (hazard ratio = 1.49; 95% CI: 0.87-2.56) was suggested in participants with impaired sleep at baseline. No more than weak associations were observed for economic hardship, major life events or inadequate social network in the current study. Overall, the hypothesis that psychosocial risk factors affect the risk of PD is not supported. The results, however, suggest that vital exhaustion may be a pre-motor marker of the neurodegenerative process eventually leading to motor symptoms and clinical PD. Vital exhaustion may be useful for screening aimed at early detection and when considering disease-modifying therapies in people at high risk of clinical PD. © 2013 The Author(s) European Journal of Neurology © 2013 EFNS.

Predator crown-of-thorns starfish (Acanthaster planci) outbreak, mass mortality of corals, and cascading effects on reef fish and benthic communities.

PubMed

Kayal, Mohsen; Vercelloni, Julie; Lison de Loma, Thierry; Bosserelle, Pauline; Chancerelle, Yannick; Geoffroy, Sylvie; Stievenart, Céline; Michonneau, François; Penin, Lucie; Planes, Serge; Adjeroud, Mehdi

2012-01-01

Outbreaks of the coral-killing seastar Acanthaster planci are intense disturbances that can decimate coral reefs. These events consist of the emergence of large swarms of the predatory seastar that feed on reef-building corals, often leading to widespread devastation of coral populations. While cyclic occurrences of such outbreaks are reported from many tropical reefs throughout the Indo-Pacific, their causes are hotly debated, and the spatio-temporal dynamics of the outbreaks and impacts to reef communities remain unclear. Based on observations of a recent event around the island of Moorea, French Polynesia, we show that Acanthaster outbreaks are methodic, slow-paced, and diffusive biological disturbances. Acanthaster outbreaks on insular reef systems like Moorea's appear to originate from restricted areas confined to the ocean-exposed base of reefs. Elevated Acanthaster densities then progressively spread to adjacent and shallower locations by migrations of seastars in aggregative waves that eventually affect the entire reef system. The directional migration across reefs appears to be a search for prey as reef portions affected by dense seastar aggregations are rapidly depleted of living corals and subsequently left behind. Coral decline on impacted reefs occurs by the sequential consumption of species in the order of Acanthaster feeding preferences. Acanthaster outbreaks thus result in predictable alteration of the coral community structure. The outbreak we report here is among the most intense and devastating ever reported. Using a hierarchical, multi-scale approach, we also show how sessile benthic communities and resident coral-feeding fish assemblages were subsequently affected by the decline of corals. By elucidating the processes involved in an Acanthaster outbreak, our study contributes to comprehending this widespread disturbance and should thus benefit targeted management actions for coral reef ecosystems.

Charging of the Van Allen Probes: Theory and Simulations

NASA Astrophysics Data System (ADS)

Delzanno, G. L.; Meierbachtol, C.; Svyatskiy, D.; Denton, M.

2017-12-01

The electrical charging of spacecraft has been a known problem since the beginning of the space age. Its consequences can vary from moderate (single event upsets) to catastrophic (total loss of the spacecraft) depending on a variety of causes, some of which could be related to the surrounding plasma environment, including emission processes from the spacecraft surface. Because of its complexity and cost, this problem is typically studied using numerical simulations. However, inherent unknowns in both plasma parameters and spacecraft material properties can lead to inaccurate predictions of overall spacecraft charging levels. The goal of this work is to identify and study the driving causes and necessary parameters for particular spacecraft charging events on the Van Allen Probes (VAP) spacecraft. This is achieved by making use of plasma theory, numerical simulations, and on-board data. First, we present a simple theoretical spacecraft charging model, which assumes a spherical spacecraft geometry and is based upon the classical orbital-motion-limited approximation. Some input parameters to the model (such as the warm plasma distribution function) are taken directly from on-board VAP data, while other parameters are either varied parametrically to assess their impact on the spacecraft potential, or constrained through spacecraft charging data and statistical techniques. Second, a fully self-consistent numerical simulation is performed by supplying these parameters to CPIC, a particle-in-cell code specifically designed for studying plasma-material interactions. CPIC simulations remove some of the assumptions of the theoretical model and also capture the influence of the full geometry of the spacecraft. The CPIC numerical simulation results will be presented and compared with on-board VAP data. This work will set the foundation for our eventual goal of importing the full plasma environment from the LANL-developed SHIELDS framework into CPIC, in order to more accurately predict spacecraft charging.

Yurchikhin in Service Module

NASA Image and Video Library

2013-06-15

ISS036-E-008165 (15 June 2013) --- Expedition 36 Flight Engineer Fyodor Yurchikhin with Russia's Federal Space Agency (Roscosmos) takes pictures of a highly anticipated event from a window in the Pirs module on the International Space Station. His electronic still camera is equipped with a 400mm lens to capture distant images of the European Space Agency's Automated Transfer Vehicle-4 (ATV-4) “Albert Einstein.” The spacecraft eventually moved in much closer and successfully docked to the orbital outpost at 2:07 GMT, June 15, 2013, following a ten-day period of free-flight.

Data indexing techniques for the EUVE all-sky survey

NASA Technical Reports Server (NTRS)

Lewis, J.; Saba, V.; Dobson, C.

1992-01-01

This poster describes techniques developed for manipulating large full-sky data sets for the Extreme Ultraviolet Explorer project. The authors have adapted the quatrilateralized cubic sphere indexing algorithm to allow us to efficiently store and process several types of large data sets, such as full-sky maps of photon counts, exposure time, and count rates. A variation of this scheme is used to index sparser data such as individual photon events and viewing times for selected areas of the sky, which are eventually used to create EUVE source catalogs.

KSC-2012-4407

NASA Image and Video Library

2012-08-14

CAPE CANAVERAL, Fla. -- National Space Club Florida Committee Chair Steve Griffin welcomes attendees of the club's August luncheon at the Radisson Resort at the Port in Cape Canaveral, Fla. NASA Commercial Crew Program Manager Ed Mango was the event's guest speaker, discussing the innovative steps the agency is taking with industry partners to develop the next U.S. space transportation capability to and from low Earth orbit, which will eventually be available for use by the U.S. government and other commercial customers. To learn more about the Commercial Crew Program, visit www.nasa.gov/commercialcrew. Photo credit: Kim Shiflett

Forward end (+XA side) of the PMA-2 prior to mating to the Orbiter Docking System (ODS).

NASA Image and Video Library

1998-12-05

STS088-335-017 (5 Dec. 1998) --- One of the STS-88 astronauts aimed a 35mm camera through Endeavour's aft flight deck windows to record this Dec. 5 image of the Unity connecting module as it was being unberthed in the cargo bay. The berthing and mating process constituted the first link in a long chain of events that led up to the eventual deployment in Earth orbit of the connected Unity and Zarya modules later in the 11-day mission. Photo credit: NASA

Strampelli's osteo-odonto-keratoprosthesis. Clinical and histological long-term features of three prostheses.

PubMed Central

Ricci, R.; Pecorella, I.; Ciardi, A.; Della Rocca, C.; Di Tondo, U.; Marchi, V.

1992-01-01

The histological features are reported of osteo-odonto-acrylic laminae removed from three patients who for differing underlying causes received Strampelli's osteo-odonto-keratoprostheses (OOK) 20, 16, and 12 years previously. It appears that preservation of the alveolar-dental ligament plays a definitive role in the maintenance of the prosthesis. If this tissue undergoes necrosis as a consequence of an inflammatory disease the implanted material is eventually lost. However when no such event occurs the OOK is well preserved and well tolerated even 20 years after implantation. Images PMID:1390492

Lead mobilization during tectonic reactivation of the western Baltic Shield

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romer, R.L.; Wright, J.E.

Lead isotope data from sulfide deposits of the western part of the Baltic Shield define mixing lines in the [sup 206]Pb/[sup 204]Pb-[sup 207]Pb/[sup 204]Pb diagram. Lead from two types of sulfide deposits have been investigated: (1) Exhalative and volcanogenic deposits that are syngenetic with their host rocks; and (2) vein deposits. The syngenetic deposits locally show a very wide range of lead isotopic compositions that reflect a variable addition of highly radiogenic lead, while the vein deposits, although they have radiogenic lead isotopic compositions, exhibit only limited isotopic variations. In different provinces of the shield, both types of deposits fallmore » on the same lead mixing array. The slope of the lead mixing lines varies as a function of the age of basement rocks and the age of the tectonic event which produced the lead mobilization and therefore relates the source rock age with the age of lead mobilization. Calculated mixing ages fall into several short time periods that correspond either to orogenic events or to major phases of continental rifting. The orogenic events are the ca 360--430 Ma Caledonian, ca 900--1100 Ma Sveconorwegian, and the ca 1800--1900 Ma Svecofennian orogenic cycles. The rifting events correspond to the formation of the ca 280 Ma Oslo rift and the Ordovician (ca 450 Ma) graben system in the area of the present Gulf of Bothnia. Each mixing age indicates that lead was mobilized, probably as a consequence of mild thermal disturbances, and that the crust was permeable to lead migration. The data show that the geographic distribution of sulfide deposits with highly radiogenic lead isotopic compositions coincides with old graben systems, orogenic belts, and orogenic forelands on the Baltic Shield. The ages of vein deposits and their geographic distribution demonstrate multiple tectonic reactivation of the interior of the Baltic Shield in response to orogenic events at its margin. 68 refs., 6 refs., 4 tabs.« less

Species-specific Mechanisms Contributing to the Mesophication of Upland Oak Stands in the Absence of Fire

NASA Astrophysics Data System (ADS)

Babl, E. K.; Alexander, H. D.; Siegert, C. M.; Willis, J. L.; Berry, A. I.

2017-12-01

Upland oak forests of the eastern United States are shifting dominance towards shade-tolerant, fire-intolerant species. This shift is hypothesized to be driven by anthropogenic fire suppression and lead to mesophication, a positive feedback loop where shade-tolerant, fire-sensitive species (i.e. mesophytes) create a cool, moist understory, reducing forest flammability and promoting their own proliferation at the expense of pyrophytic, shade-intolerant species such as oaks. There have been few empirical studies identifying mechanisms of mesophication, and these studies have yet to extensively explore potential mesophytes other than red maple (Acer rubrum). To address this issue, we sampled four hypothesized mesophytes (A. rubrum, A. saccharum, Carya glabra, and Fagus grandifolia) and two upland oak species (Quercus alba and Q. montana) across a gradient of sizes (20-60 cm DBH) in western Kentucky. We quantified canopy, bark, and leaf litter traits among upland oaks and mesophytes that may lead to differences in forest flammability. Preliminary results show that mesophytes had thinner and smoother bark than upland oaks and an increased canopy volume (normalized to stem volume), traits known to influence water movement through the canopy and understory microclimate. Maple leaf litter also decomposed faster, which could decrease fuel loads; after 6 months, red and sugar maple leaf litter lost 37% of original mass compared to 32%, 22%, and 14% mass loss in hickory, oak, and American beech litter, respectively. Furthermore, volumetric soil moisture of the soil organic layer beneath the canopies of mesophytes was 62% moister two days following a rainfall event compared to oaks. These differences in soil organic layer water retention after rainfall could lead to fuel discontinuity. These findings suggest that mesophytes may alter future forest flammability through their bark, canopy, and leaf litter traits which may modify fuel moisture, loads, and continuity and that a mesophication tipping point may eventually occur that prevents restoration efforts using prescribed fire.

Altered cropping pattern and cultural continuation with declined prosperity following abrupt and extreme arid event at ~4,200 yrs BP: Evidence from an Indus archaeological site Khirsara, Gujarat, western India

PubMed Central

Pokharia, Anil K.; Sharma, Shalini; Bajpai, Sunil; Nath, Jitendra; Kumaran, R. N.; Negi, Bipin Chandra

2017-01-01

Archaeological sites hold important clues to complex climate-human relationships of the past. Human settlements in the peripheral zone of Indus culture (Gujarat, western India) are of considerable importance in the assessment of past monsoon-human-subsistence-culture relationships and their survival thresholds against climatic stress exerted by abrupt changes. During the mature phase of Harappan culture between ~4,600–3,900yrsBP, the ~4,100±100yrsBP time slice is widely recognized as one of the major, abrupt arid-events imprinted innumerous well-dated palaeo records. However, the veracity of this dry event has not been established from any archaeological site representing the Indus (Harappan) culture, and issues concerning timing, changes in subsistence pattern, and the likely causes of eventual abandonment (collapse) continue to be debated. Here we show a significant change in crop-pattern (from barley-wheat based agriculture to ‘drought-resistant’ millet-based crops) at ~4,200 yrs BP, based on abundant macrobotanical remains and C isotopes of soil organic matter (δ13CSOM) in an archaeological site at Khirsara, in the Gujarat state of western India. The crop-change appears to be intentional and was likely used as an adaptation measure in response to deteriorated monsoonal conditions. The ceramic and architectural remains of the site indicate that habitation survived and continued after the ~4,200yrsBP dry climatic phase, but with declined economic prosperity. Switching to millet-based crops initially helped inhabitants to avoid immediate collapse due to climatic stresses, but continued aridity and altered cropping pattern led to a decline in prosperity levels of inhabitants and eventual abandonment of the site at the end of the mature Harappan phase. PMID:28985232

Leading a highly visible hospital through a serious reportable event.

PubMed

Erickson, Jeanette Ives

2012-03-01

Most preventable adverse events result from systemic causes, not human error. The senior vice president for patient care/chief nurse at a leading hospital recounts the unnecessary death of a patient and the investigation that followed. Citing the critical importance of a "just culture," this case study offers a blueprint for managing a serious reportable event.

Lead poisoning in cattle and horses in the vicinity of a smelter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hammond, P.B.; Aronson, A.L.

1964-01-01

An outbreak of lead poisoning near a smelter is described. Fatalities in horses and cattle occurred. Data presented concern the pattern and degree of contamination in animals and vegetation. The daily intake of approximately 6-7 mg. Pb/kg appears to be close to the minimum which eventually gives rise to signs of poisoning in cattle. Horses appear to be somewhat more susceptible. Even under conditions of chronic lead intake, the syndrome in cattle generally is acute or peracute. The concentration of lead in milk is linearly related to the concentration in blood cells at a ratio Pb cells/Pb milk of approximatelymore » 23. Evidence is presented indicating that relief of the burden of lead in tissues with EDTA therapy following chronic intake of the metal is a hazardous procedure. Data gathered by the Minnesota State Health Department during the episode indicate that people in the area and their water supply were not affected. 31 references.« less

Toward an automated signature recognition toolkit for mission operations

NASA Technical Reports Server (NTRS)

Cleghorn, T.; Laird, P; Perrine, L.; Culbert, C.; Macha, M.; Saul, R.; Hammen, D.; Moebes, T.; Shelton, R.

1994-01-01

Signature recognition is the problem of identifying an event or events from its time series. The generic problem has numerous applications to science and engineering. At NASA's Johnson Space Center, for example, mission control personnel, using electronic displays and strip chart recorders, monitor telemetry data from three-phase electrical buses on the Space Shuttle and maintain records of device activation and deactivation. Since few electrical devices have sensors to indicate their actual status, changes of state are inferred from characteristic current and voltage fluctuations. Controllers recognize these events both by examining the waveform signatures and by listening to audio channels between ground and crew. Recently the authors have developed a prototype system that identifies major electrical events from the telemetry and displays them on a workstation. Eventually the system will be able to identify accurately the signatures of over fifty distinct events in real time, while contending with noise, intermittent loss of signal, overlapping events, and other complications. This system is just one of many possible signature recognition applications in Mission Control. While much of the technology underlying these applications is the same, each application has unique data characteristics, and every control position has its own interface and performance requirements. There is a need, therefore, for CASE tools that can reduce the time to implement a running signature recognition application from months to weeks or days. This paper describes our work to date and our future plans.

Toward an automated signature recognition toolkit for mission operations

NASA Astrophysics Data System (ADS)

Cleghorn, T.; Laird, P.; Perrine, L.; Culbert, C.; Macha, M.; Saul, R.; Hammen, D.; Moebes, T.; Shelton, R.

1994-10-01

Signature recognition is the problem of identifying an event or events from its time series. The generic problem has numerous applications to science and engineering. At NASA's Johnson Space Center, for example, mission control personnel, using electronic displays and strip chart recorders, monitor telemetry data from three-phase electrical buses on the Space Shuttle and maintain records of device activation and deactivation. Since few electrical devices have sensors to indicate their actual status, changes of state are inferred from characteristic current and voltage fluctuations. Controllers recognize these events both by examining the waveform signatures and by listening to audio channels between ground and crew. Recently the authors have developed a prototype system that identifies major electrical events from the telemetry and displays them on a workstation. Eventually the system will be able to identify accurately the signatures of over fifty distinct events in real time, while contending with noise, intermittent loss of signal, overlapping events, and other complications. This system is just one of many possible signature recognition applications in Mission Control. While much of the technology underlying these applications is the same, each application has unique data characteristics, and every control position has its own interface and performance requirements. There is a need, therefore, for CASE tools that can reduce the time to implement a running signature recognition application from months to weeks or days. This paper describes our work to date and our future plans.

A study of axonal degeneration in the optic nerves of aging mice

NASA Technical Reports Server (NTRS)

Johnson, J. E., Jr.; Philpott, D. E.; Miquel, J.

1978-01-01

The optic nerves of C57BL/6J mice ranging from 3 to 30 months were examined by electron microscopy. At all ages investigated, optic nerve axons contained enlarged mitochondria with abnormal cristae. With increasing age, a large number of necrotic axons were observed and were in the process of being phagocytized. The abnormal mitochondria may represent preliminary changes that eventually lead to necrosis of the axon.

The New Soviet Strategy in the Third World.

DTIC Science & Technology

1983-06-01

prerequisite for the achievement of complete independence and eventual transition to socialism. More important, the national bourgeoisie was recognized as a...Future?" Conflict Studies, No. 95, May 1978; also see Marina Ottaway, "The Theory and Practice of Marxism -Leninism in Mozambique and Ethiopia," in...absolutely identical." 2 Frelimo’s statements stress the leading role of the party in Mozambique society on the basis of Marxism -Leninism and . calls

Endocrine Therapy of Breast Cancer

DTIC Science & Technology

2009-06-01

the LCCC and shared fully with the broader research community . Our adoption of caBIG and our activities in this large federally funded research... community also allows us to share our expertise and tools with many other cancer researchers. We also continue to further develop and optimize our...cell growth arrest in M1, eventually leading to critically short telomeres and massive cell death or “mortality stage 2 (M2)” or “ crisis .” Individual

Heavy Metal Contaminated Soil Treatment: Conceptual Development

DTIC Science & Technology

1987-02-01

utilized, particularly for trivalent chromium . ’Breakthrough did eventually occur, due to the coating of the crushed limestone, with only partial...characterizations indicated that several Army installations had elevated total metal concentrations in their soils and Chromium , Cadmium and Lead were the most...2,2000 F) were effective in reducing chromium levels below 1 mg/L in both boiling water and weak acid (pH 5; H2 SO 4) extractions. These extractions were

Robust Intelligence (RI) Under Uncertainty: Mathematical Foundations of Autonomous Hybrid (Human-Machine-Robot) Teams, Organizations and Systems

DTIC Science & Technology

2013-01-01

seeds of chaos. Stability and internal peace bring prosperity; prosperity causes population increase. Demographic growth leads to overpopulation ... overpopulation causes lower wages, higher land rents, and falling per-capita incomes … [Eventually, the] collapse of order brings … famine, war...one of the most innovative, competitive and largest firms in the world (e.g., Investors Business Daily, 2000, 10/31; Bloomberg’s Businessweek, 2001, 9

Natural and Artificial Satellite Dynamics and Evolution around Near-Earth Asteroids with Solar Radiation Pressure

NASA Astrophysics Data System (ADS)

Rieger, Samantha M.

Natural and artificial satellites are subject to perturbations when orbiting near-Earth asteroids. These perturbations include non-uniform gravity from the asteroid, third-body disturbances from the Sun, and solar radiation pressure. For small natural (1 cm-15 m) and artificial satellites, solar radiation pressure is the primary perturbation that will cause their orbits to go unstable. For the asteroid Bennu, the future target of the spacecraft OSIRIS-REx, the possibility of natural satellites having stable orbits around the asteroid and characterize these stable regions is investigated. It has been found that the main orbital phenomena responsible for the stability or instability of these possible natural satellites are Sun-synchronous orbits, the modified Laplace plane, and the Kozai resonance. These findings are applied to other asteroids as well as to artificial satellites. The re-emission of solar radiation pressure through BYORP is also investigated for binary asteroid systems. Specifically, the BYORP force is combined with the Laplace plane such that BYORP expands the orbit of the binary system along the Laplace surface where the secondary increases in inclination. For obliquities from 68.875° - 111.125° the binary will eventually extend into the Laplace instability region, where the eccentricity of the orbit will increase. A subset of the instability region leads to eccentricities high enough that the secondary will impact the primary. This result inspired the development of a hypothesis of a contact-binary binary cycle described briefly in the following. YORP will increase the spin rate of a contact binary while also driving the spin-pole to an obliquity of 90°. Eventually, the contact binary will fission. The binary will subsequently become double-synchronous, thus allowing the BYORP acceleration to have secular effects on the orbit. The orbit will then expand along the Laplace surface to the Laplace plane instability region eventually leading to an impact and the start of a new cycle with the YORP process.

First In-Human Experience With Complete Integration of Neuromodulation Device Within a Customized Cranial Implant.

PubMed

Gordon, Chad R; Santiago, Gabriel F; Huang, Judy; Bergey, Gregory K; Liu, Shuya; Armand, Mehran; Brem, Henry; Anderson, William S

2017-10-06

Neuromodulation devices have the potential to transform modern day treatments for patients with medicine-resistant neurological disease. For instance, the NeuroPace System (NeuroPace Inc, Mountain View, California) is a Food and Drug Administration (FDA)-approved device developed for closed-loop direct brain neurostimulation in the setting of drug-resistant focal epilepsy. However, current methods require placement either above or below the skull in nonanatomic locations. This type of positioning has several drawbacks including visible deformities and scalp pressure from underneath leading to eventual wound healing difficulties, micromotion of hardware with infection, and extrusion leading to premature explantation. To introduce complete integration of a neuromodulation device within a customized cranial implant for biocompatibility optimization and prevention of visible deformity. We report a patient with drug-resistant focal epilepsy despite previous seizure surgery and maximized medical therapy. Preoperative imaging demonstrated severe resorption of previous bone flap causing deformity and risk for injury. She underwent successful responsive neurostimulation device implantation via complete integration within a clear customized cranial implant. The patient has recovered well without complication and has been followed closely for 180 d. Device interrogation with electrocorticographic data transmission has been successfully performed through the clear implant material for the first time with no evidence of any wireless transmission interference. Cranial contour irregularities, implant site infection, and bone flap resorption/osteomyelitis are adverse events associated with implantable neurotechnology. This method represents a novel strategy to incorporate all future neuromodulation devices within the confines of a low-profile, computer-designed cranial implant and the newfound potential to eliminate contour irregularities, improve outcomes, and optimize patient satisfaction. Copyright © 2017 by the Congress of Neurological Surgeons

Ocean deoxygenation, the global phosphorus cycle and the possibility of human-caused large-scale ocean anoxia.

PubMed

Watson, Andrew J; Lenton, Timothy M; Mills, Benjamin J W

2017-09-13

The major biogeochemical cycles that keep the present-day Earth habitable are linked by a network of feedbacks, which has led to a broadly stable chemical composition of the oceans and atmosphere over hundreds of millions of years. This includes the processes that control both the atmospheric and oceanic concentrations of oxygen. However, one notable exception to the generally well-behaved dynamics of this system is the propensity for episodes of ocean anoxia to occur and to persist for 10 5 -10 6 years, these ocean anoxic events (OAEs) being particularly associated with warm 'greenhouse' climates. A powerful mechanism responsible for past OAEs was an increase in phosphorus supply to the oceans, leading to higher ocean productivity and oxygen demand in subsurface water. This can be amplified by positive feedbacks on the nutrient content of the ocean, with low oxygen promoting further release of phosphorus from ocean sediments, leading to a potentially self-sustaining condition of deoxygenation. We use a simple model for phosphorus in the ocean to explore this feedback, and to evaluate the potential for humans to bring on global-scale anoxia by enhancing P supply to the oceans. While this is not an immediate global change concern, it is a future possibility on millennial and longer time scales, when considering both phosphate rock mining and increased chemical weathering due to climate change. Ocean deoxygenation, once begun, may be self-sustaining and eventually could result in long-lasting and unpleasant consequences for the Earth's biosphere.This article is part of the themed issue 'Ocean ventilation and deoxygenation in a warming world'. © 2017 The Authors.

Ocean deoxygenation, the global phosphorus cycle and the possibility of human-caused large-scale ocean anoxia

PubMed Central

Lenton, Timothy M.; Mills, Benjamin J. W.

2017-01-01

The major biogeochemical cycles that keep the present-day Earth habitable are linked by a network of feedbacks, which has led to a broadly stable chemical composition of the oceans and atmosphere over hundreds of millions of years. This includes the processes that control both the atmospheric and oceanic concentrations of oxygen. However, one notable exception to the generally well-behaved dynamics of this system is the propensity for episodes of ocean anoxia to occur and to persist for 105–106 years, these ocean anoxic events (OAEs) being particularly associated with warm ‘greenhouse’ climates. A powerful mechanism responsible for past OAEs was an increase in phosphorus supply to the oceans, leading to higher ocean productivity and oxygen demand in subsurface water. This can be amplified by positive feedbacks on the nutrient content of the ocean, with low oxygen promoting further release of phosphorus from ocean sediments, leading to a potentially self-sustaining condition of deoxygenation. We use a simple model for phosphorus in the ocean to explore this feedback, and to evaluate the potential for humans to bring on global-scale anoxia by enhancing P supply to the oceans. While this is not an immediate global change concern, it is a future possibility on millennial and longer time scales, when considering both phosphate rock mining and increased chemical weathering due to climate change. Ocean deoxygenation, once begun, may be self-sustaining and eventually could result in long-lasting and unpleasant consequences for the Earth's biosphere. This article is part of the themed issue ‘Ocean ventilation and deoxygenation in a warming world’. PMID:28784709

Blocking the 4-1BB Pathway Ameliorates Crystalline Silica-induced Lung Inflammation and Fibrosis in Mice

PubMed Central

Li, Chao; Du, Sitong; Lu, Yiping; Lu, Xiaowei; Liu, Fangwei; Chen, Ying; Weng, Dong; Chen, Jie

2016-01-01

Long term pulmonary exposure to crystalline silica leads to silicosis that manifests progressive interstitial fibrosis, eventually leading to respiratory failure and death. Despite efforts to eliminate silicosis, clinical cases continue to occur in both developing and developed countries. The exact mechanisms of crystalline silica-induced pulmonary fibrosis remain elusive. Herein, we find that 4-1BB is induced in response to crystalline silica injury in lungs and that it is highly expressed during development of experimental silicosis. Therefore, we explore the role of 4-1BB pathway during crystalline silica-induced lung injury and find that a specific inhibitor blocking the pathway could effectively alleviate crystalline silica-induced lung inflammation and subsequent pulmonary fibrosis in vivo. Compared to controls, the treated mice exhibited reduced Th1 and Th17 responses. The concentrations of pro-inflammatory cytokines in bronchoalveolar lavage fluid (BALF), including tumor necrosis factor (TNF)-α, interferon (IFN)-γ and interleukin (IL)-17A following crystalline silica challenge were also reduced in inhibitor-treated mice. Although there was no significant alteration in Th2 cytokines of IL-4 and IL-13, another type of pro-fibrogenic cell, regulatory T cell (Treg) was significantly affected. In addition, one of the major participants in fibrogenesis, fibrocyte recruited less due to the blockade. Furthermore, we demonstrated the decreased fibrocyte recruitment was associated with chemokine reductions in lung. Our study discovers the 4-1BB pathway signaling enhances inflammatory response and promotes pulmonary fibrosis induced by crystalline silica. The findings here provide novel insights into the molecular events that control crystalline silica-induced lung inflammation and fibrosis through regulating Th responses and the recruitment of fibrocytes in crystalline silica-exposed lung. PMID:27698940

Neurochemical differences in learning and memory paradigms among rats supplemented with anthocyanin-rich blueberry diets and exposed to acute doses of 56Fe particles

NASA Astrophysics Data System (ADS)

Poulose, Shibu M.; Rabin, Bernard M.; Bielinski, Donna F.; Kelly, Megan E.; Miller, Marshall G.; Thanthaeng, Nopporn; Shukitt-Hale, Barbara

2017-02-01

The protective effects of anthocyanin-rich blueberries (BB) on brain health are well documented and are particularly important under conditions of high oxidative stress, which can lead to "accelerated aging." One such scenario is exposure to space radiation, consisting of high-energy and -charge particles (HZE), which are known to cause cognitive dysfunction and deleterious neurochemical alterations. We recently tested the behavioral and neurochemical effects of acute exposure to HZE particles such as 56Fe, within 24-48 h after exposure, and found that radiation primarily affects memory and not learning. Importantly, we observed that specific brain regions failed to upregulate antioxidant and anti-inflammatory mechanisms in response to this insult. To further examine these endogenous response mechanisms, we have supplemented young rats with diets rich in BB, which are known to contain high amounts of antioxidant-phytochemicals, prior to irradiation. Exposure to 56Fe caused significant neurochemical changes in hippocampus and frontal cortex, the two critical regions of the brain involved in cognitive function. BB supplementation significantly attenuated protein carbonylation, which was significantly increased by exposure to 56Fe in the hippocampus and frontal cortex. Moreover, BB supplementation significantly reduced radiation-induced elevations in NADPH-oxidoreductase-2 (NOX2) and cyclooxygenase-2 (COX-2), and upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) in the hippocampus and frontal cortex. Overall results indicate that 56Fe particles may induce their toxic effects on hippocampus and frontal cortex by reactive oxygen species (ROS) overload, which can cause alterations in the neuronal environment, eventually leading to hippocampal neuronal death and subsequent impairment of cognitive function. Blueberry supplementation provides an effective preventative measure to reduce the ROS load on the CNS in an event of acute HZE exposure.

Benefits of Synchrotron Microangiography for Dynamic Studies of Smooth Muscle and Endothelial Roles in the Pathophysiology of Vascular Disease

NASA Astrophysics Data System (ADS)

Pearson, James T.; Schwenke, Daryl O.; Jenkins, Mathew J.; Edgley, Amanda J.; Sonobe, Takashi; Ishibashi-Ueda, Hatsue; Umetani, Keiji; Eppel, Gabriela A.; Evans, Roger G.; Okura, Yasuhiko; Shirai, Mikiyasu

2010-07-01

Changes in endothelial and smooth muscle function compromise organ perfusion in the chronic disease states of diabetes, atherosclerosis and hypertension. Moreover, vascular dysfunction increases the likelihood of lethal acute events such as myocardial infarction and stroke, which are now leading causes of adult mortality. Many circulating and local tissue factors in these disease states contribute to impaired vasomotor regulation of the arterial vessels, leading to spasm, chronic constriction and eventually vessel remodelling. X-ray contrast absorption imaging allows assessment of vessel lumen diameter and the factors contributing to steady-state vessel calibre, however, conventional clinical devices (>200 μm resolution) are not adequate to detect microvessels or accurately assess function in real time. Using synchrotron imaging we are now able to detect small vessel calibres (˜30 μm) and quantify regional differences in calibre even under conditions of high heart rate (>500 bpm). Herein we describe recent experiments that were conducted at the Japanese Synchrotron, SPring-8 using anaesthetised Sprague-Dawley rats and C57Bl/6 mice and a synchrotron radiation contrast angiography (single narrow energy bandwidth) approach based on selective arterial injection of iodine contrast agents. Application of this approach to imaging of the heart and other vasculatures are described. Our studies show that within-animal comparisons of 3-4 branching orders of arterial vessels are possible using small bolus contrast injections and appropriate contrast washout times (15-30 min) in many organ systems. Determination of relative calibre changes before and after any treatment allows us to evaluate the contributions of different endogenous factors and ligand-receptor pathways in the maintenance of vasomotor tone. Finally, we will present our findings relating to novel therapies to prevent endothelial dysfunction in heart failure.

Benefits of Synchrotron Microangiography for Dynamic Studies of Smooth Muscle and Endothelial Roles in the Pathophysiology of Vascular Disease

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pearson, James T.; Department of Physiology, Monash University, 3800 Clayton; Schwenke, Daryl O.

2010-07-23

Changes in endothelial and smooth muscle function compromise organ perfusion in the chronic disease states of diabetes, atherosclerosis and hypertension. Moreover, vascular dysfunction increases the likelihood of lethal acute events such as myocardial infarction and stroke, which are now leading causes of adult mortality. Many circulating and local tissue factors in these disease states contribute to impaired vasomotor regulation of the arterial vessels, leading to spasm, chronic constriction and eventually vessel remodelling. X-ray contrast absorption imaging allows assessment of vessel lumen diameter and the factors contributing to steady-state vessel calibre, however, conventional clinical devices (>200 {mu}m resolution) are not adequatemore » to detect microvessels or accurately assess function in real time. Using synchrotron imaging we are now able to detect small vessel calibres ({approx}30 {mu}m) and quantify regional differences in calibre even under conditions of high heart rate (>500 bpm). Herein we describe recent experiments that were conducted at the Japanese Synchrotron, SPring-8 using anaesthetised Sprague-Dawley rats and C57Bl/6 mice and a synchrotron radiation contrast angiography (single narrow energy bandwidth) approach based on selective arterial injection of iodine contrast agents. Application of this approach to imaging of the heart and other vasculatures are described. Our studies show that within-animal comparisons of 3-4 branching orders of arterial vessels are possible using small bolus contrast injections and appropriate contrast washout times (15-30 min) in many organ systems. Determination of relative calibre changes before and after any treatment allows us to evaluate the contributions of different endogenous factors and ligand-receptor pathways in the maintenance of vasomotor tone. Finally, we will present our findings relating to novel therapies to prevent endothelial dysfunction in heart failure.« less

Researching glutamate – induced cytotoxicity in different cell lines: a comparative/collective analysis/study

PubMed Central

Kritis, Aristeidis A.; Stamoula, Eleni G.; Paniskaki, Krystallenia A.; Vavilis, Theofanis D.

2015-01-01

Although glutamate is one of the most important excitatory neurotransmitters of the central nervous system, its excessive extracellular concentration leads to uncontrolled continuous depolarization of neurons, a toxic process called, excitotoxicity. In excitotoxicity glutamate triggers the rise of intracellular Ca2+ levels, followed by up regulation of nNOS, dysfunction of mitochondria, ROS production, ER stress, and release of lysosomal enzymes. Excessive calcium concentration is the key mediator of glutamate toxicity through over activation of ionotropic and metabotropic receptors. In addition, glutamate accumulation can also inhibit cystine (CySS) uptake by reversing the action of the CySS/glutamate antiporter. Reversal of the antiporter action reinforces the aforementioned events by depleting neurons of cysteine and eventually glutathione’s reducing potential. Various cell lines have been employed in the pursuit to understand the mechanism(s) by which excitotoxicity affects the cells leading them ultimately to their demise. In some cell lines glutamate toxicity is exerted mainly through over activation of NMDA, AMPA, or kainate receptors whereas in other cell lines lacking such receptors, the toxicity is due to glutamate induced oxidative stress. However, in the greatest majority of the cell lines ionotropic glutamate receptors are present, co-existing to CySS/glutamate antiporters and metabotropic glutamate receptors, supporting the assumption that excitotoxicity effect in these cells is accumulative. Different cell lines differ in their responses when exposed to glutamate. In this review article the responses of PC12, SH-SY5Y, HT-22, NT-2, OLCs, C6, primary rat cortical neurons, RGC-5, and SCN2.2 cell systems are systematically collected and analyzed. PMID:25852482

Association study of sorbitol dehydrogenase -888G>C polymorphism with type 2 diabetic retinopathy in Caucasian-Brazilians.

PubMed

Ferreira, Fábio Netto; Crispim, Daisy; Canani, Luís Henrique; Gross, Jorge Luiz; dos Santos, Kátia Gonçalves

2013-10-01

Diabetic retinopathy (DR) is a common chronic complication of diabetes and remains the leading cause of blindness in working-aged people. Hyperglycemia increases glucose flux through the polyol pathway, in which aldose reductase converts glucose into intracellular sorbitol, which is subsequently converted to fructose by sorbitol dehydrogenase (SDH). The accelerated polyol pathway triggers a cascade of events leading to retinal vascular endothelial dysfunction and the eventual development of DR. Polymorphisms in the gene encoding aldose reductase have been consistently associated with DR. However, only two studies have analyzed the relationship between polymorphisms in the gene encoding SDH (SORD) and DR. In this case-control study, we investigated whether the -888G > C polymorphism (rs3759890) in the SORD gene is associated with the presence or severity of DR in 446 Caucasian-Brazilians with type 2 diabetes (241 subjects with and 205 subjects without DR). The -888G > C polymorphism was also examined in 105 healthy Caucasian blood donors, and the genotyping of this polymorphism was carried out by real-time PCR. The genotype and allele frequencies of the -888G > C polymorphism in patients with type 2 diabetes were similar to those of blood donors (G allele frequency = 0.16 in both groups of subjects). Similarly, the genotype and allele frequencies in patients with DR or the proliferative form of DR were similar to those of patients without this complication (P > 0.05 for all comparisons). Thus, our findings suggest that the -888G > C polymorphism in the SORD gene is not involved in the pathogenesis of DR in type 2 diabetes. Copyright © 2013 Elsevier Ltd. All rights reserved.

Blocking the 4-1BB Pathway Ameliorates Crystalline Silica-induced Lung Inflammation and Fibrosis in Mice.

PubMed

Li, Chao; Du, Sitong; Lu, Yiping; Lu, Xiaowei; Liu, Fangwei; Chen, Ying; Weng, Dong; Chen, Jie

2016-01-01

Long term pulmonary exposure to crystalline silica leads to silicosis that manifests progressive interstitial fibrosis, eventually leading to respiratory failure and death. Despite efforts to eliminate silicosis, clinical cases continue to occur in both developing and developed countries. The exact mechanisms of crystalline silica-induced pulmonary fibrosis remain elusive. Herein, we find that 4-1BB is induced in response to crystalline silica injury in lungs and that it is highly expressed during development of experimental silicosis. Therefore, we explore the role of 4-1BB pathway during crystalline silica-induced lung injury and find that a specific inhibitor blocking the pathway could effectively alleviate crystalline silica-induced lung inflammation and subsequent pulmonary fibrosis in vivo. Compared to controls, the treated mice exhibited reduced Th1 and Th17 responses. The concentrations of pro-inflammatory cytokines in bronchoalveolar lavage fluid (BALF), including tumor necrosis factor (TNF)-α, interferon (IFN)-γ and interleukin (IL)-17A following crystalline silica challenge were also reduced in inhibitor-treated mice. Although there was no significant alteration in Th2 cytokines of IL-4 and IL-13, another type of pro-fibrogenic cell, regulatory T cell (Treg) was significantly affected. In addition, one of the major participants in fibrogenesis, fibrocyte recruited less due to the blockade. Furthermore, we demonstrated the decreased fibrocyte recruitment was associated with chemokine reductions in lung. Our study discovers the 4-1BB pathway signaling enhances inflammatory response and promotes pulmonary fibrosis induced by crystalline silica. The findings here provide novel insights into the molecular events that control crystalline silica-induced lung inflammation and fibrosis through regulating Th responses and the recruitment of fibrocytes in crystalline silica-exposed lung.

Dynamical evolution of young binaries and multiple systems

NASA Astrophysics Data System (ADS)

Reipurth, B.

Most stars, and perhaps all, are born in small multiple systems whose components interact, leading to chaotic dynamic behavior. Some components are ejected, either into distant orbits or into outright escapes, while the remaining components form temporary and eventually permanent binary systems. More than half of all such breakups of multiple systems occur during the protostellar phase, leading to the occasional ejection of protostars outside their nascent cloud cores. Such orphaned protostars are observed as wide companions to embedded protostars, and thus allow the direct study of protostellar objects. Dynamic interactions during early stellar evolution explain the shape and enormous width of the separation distribution function of binaries, from close spectroscopic binaries to the widest binaries.

Linking cases of illegal shootings of the endangered California condor using stable lead isotope analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Finkelstein, Myra E., E-mail: myraf@ucsc.edu; Kuspa, Zeka E.; Welch, Alacia

Lead poisoning is preventing the recovery of the critically endangered California condor (Gymnogyps californianus) and lead isotope analyses have demonstrated that ingestion of spent lead ammunition is the principal source of lead poisoning in condors. Over an 8 month period in 2009, three lead-poisoned condors were independently presented with birdshot embedded in their tissues, evidencing they had been shot. No information connecting these illegal shooting events existed and the timing of the shooting(s) was unknown. Using lead concentration and stable lead isotope analyses of feathers, blood, and recovered birdshot, we observed that: i) lead isotope ratios of embedded shot frommore » all three birds were measurably indistinguishable from each other, suggesting a common source; ii) lead exposure histories re-constructed from feather analysis suggested that the shooting(s) occurred within the same timeframe; and iii) two of the three condors were lead poisoned from a lead source isotopically indistinguishable from the embedded birdshot, implicating ingestion of this type of birdshot as the source of poisoning. One of the condors was subsequently lead poisoned the following year from ingestion of a lead buckshot (blood lead 556 µg/dL), illustrating that ingested shot possess a substantially greater lead poisoning risk compared to embedded shot retained in tissue (blood lead ∼20 µg/dL). To our knowledge, this is the first study to use lead isotopes as a tool to retrospectively link wildlife shooting events. - Highlights: • We conducted a case-based analysis of illegal shootings of California condors. • Blood and feather Pb isotopes were used to reconstruct the illegal shooting events. • Embedded birdshot from the three condors had the same Pb isotope ratios. • Feather and blood Pb isotopes indicated that the condors were shot in a common event. • Ingested shot causes substantially greater lead exposure compared to embedded shot.« less

Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice.

PubMed

Ma, Wenqiang; Li, Shihua; Ma, Shuoqian; Jia, Lina; Zhang, Fuchun; Zhang, Yong; Zhang, Jingyuan; Wong, Gary; Zhang, Shanshan; Lu, Xuancheng; Liu, Mei; Yan, Jinghua; Li, Wei; Qin, Chuan; Han, Daishu; Qin, Chengfeng; Wang, Na; Li, Xiangdong; Gao, George Fu

2016-12-01

Zika virus (ZIKV) persists in the semen of male patients, a first for flavivirus infection. Here, we demonstrate that ZIKV can induce inflammation in the testis and epididymidis, but not in the prostate or seminal vesicle, and can lead to damaged testes after 60 days post-infection in mice. ZIKV induces innate immune responses in Leydig, Sertoli, and epididymal epithelial cells, resulting in the production of pro-inflammatory cytokines/chemokines. However, ZIKV does not induce a rapid and abundant cytokine production in peritubular cell and spermatogonia, suggesting that these cells are vulnerable for ZIKV infection and could be the potential repositories for ZIKV. Our study demonstrates a correlation between ZIKV and testis infection/damage and suggests that ZIKV infection, under certain circumstances, can eventually lead to male infertility. Copyright © 2016 Elsevier Inc. All rights reserved.

Defect-mediated spatial complexity and chaos in a phase-conjugate resonator

NASA Technical Reports Server (NTRS)

Indebetouw, Guy; Liu, Siuying R.

1992-01-01

We have studied the spatiotemporal dynamics of a phase-conjugate resonator. The cavity Fresnel number is used to vary the degree of transverse confinement of the system. The generation and subsequent motion of the phase defects in the wave front are seen to mediate the system's dynamics. The number of defects and the complexity of their motion increases as the confinement is relaxed, leading the system through a sequence of bifurcations and eventually to chaos.

A Functional Theory of Creative Reading

DTIC Science & Technology

1994-01-01

small an area results in a theory having to explain too much outside its scope, leading to overload and eventual failure . We present a functional...of several of the issues which a reading system must address. I’m an archaeologist, and Men are my business . Just the same, I wonder if we’ll ever...formal business setting. Several of these social relations can be seen in Men Are Different: the protagonist is a peer among the robot archaeologists

Redox Regulation in Bone Marrow Failure

DTIC Science & Technology

2012-06-01

Fanconi anemia mutation for hematopoietic senescence. J Cell Sci, 2007. 120(Pt 9): p. 1572-83. 2. Aylon, Y. and M. Oren, Living with p53, dying of p53...aplastic anemia patients with a p38 MAPK inhibitor can restore defective hematopoietic activity, suggesting the critical role of p38 in bone marrow...hematopoietic stem cells, and eventually leading to bone marrow failure [7, 8] [9] [10]. On the other hand, treating aplastic anemia patients with a p38

Electric Dipole Moments of Light Nuclei From Chiral Effective Field Theory

NASA Astrophysics Data System (ADS)

Higa, R.

2013-08-01

Recent calculations of EDMs of light nuclei in the framework of chiral effective field theory are presented. We argue that they can be written in terms of the leading six low-energy constants encoding CP-violating physics. EDMs of the deuteron, triton, and helion are explicitly given in order to corroborate our claim. An eventual non-zero measurement of these EDMs can be used to disentangle the different sources and strengths of CP-violation.

Researchers unmask secret to long-lasting effects of botulinum neurotoxin A in motor neurons | Center for Cancer Research

Cancer.gov

A team of scientists led by the Center for Cancer Research's Allan M. Weissman, M.D., and Yien Che Tsai, Ph.D., has discovered a molecular mechanism that explains the extreme toxicity of botulinum neurotoxin A (BoNT/A), the most potent BoNT strain. The discovery, published June 5 in PNAS, also identifies a molecular target that the researchers hope will eventually lead to

Aerophagia due to abdomino-phrenic dyssynergia in a 2-year-old child.

PubMed

Ercoli, Pablo; García, Belinda; Del Campo, Enrique; Pinillos, Sergio

2018-05-01

We report the case of a previously healthy 2-year-old child who presented with significant abdominal distension. After several interventions that proved ineffective, pathologic aerophagia was eventually diagnosed. In pediatrics, pathologic aerophagia is an uncommon disorder that almost exclusively affects children with an underlying neurological condition. It may lead to multiple diagnostic tests and unnecessary aggressive therapies. A recent case report associated aerophagia with a novel concept of abdomino-phrenic dyssynergia.

Monitoring the Future: National Survey Results on Drug Use, 1975-2003. Volume I: Secondary School Students 2003. NIH Publication No. 04-5507

ERIC Educational Resources Information Center

Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.; Schulenberg, John E.

2004-01-01

The use of licit and illicit drugs by American young people has been a source of major policy and public health concerns for the United States since the mid-1960s. The use of these substances is a leading cause of eventual disease and death in the population, but it also contributes in important ways to mortality and morbidity during adolescence. …

The Future of US Nuclear Deterrence and the Impact of the Global Zero Movement

DTIC Science & Technology

2013-02-10

The most appealing GZC recommendation is for a de facto minimum deterrence model en route to GZ. To its detriment, however, the GZC proposal relies...difficult to dispute that this path leads, at least eventually, to a minimum deterrence model . It is likely that the US can continue to wield a...instead, a capable, credible deterrent is critical to countering these threats and is especially so in a minimum deterrence model . Two key

A Student View of Experimental Physics

NASA Astrophysics Data System (ADS)

Bu, Frank; Marlowe, Robert Lloyd; Whitson, Kristin

2017-03-01

This is the story of how an enterprising high school student came to my lab one afternoon, asking if there were any way that he could gain "hands-on" lab experience by working with me. While I had some doubts about allowing him to work in an area with an expensive 150-mW focused laser beam, I eventually said yes. I was well aware that a couple of weeks of lab work could lead to interesting investigations for him….

DS2 Container and Weatherproofing Study

DTIC Science & Technology

1990-12-01

compatible with polyurethane based coating systems in general? Is it compatible with alkyd -based coatings? 10. How well do the labels placed on the...of the (older) alkyd enamel and (more recently) polyurethane camouflage coatings, leading eventually to seepage of the DS2. A shrink-wrap overpack...by John Wiley and Sons, Inc., Vol. 2, pp. 118- 119; Vol. 4, p. 3 and pp. 284-295; Vol. I, p. 133. 8. Fiber Composite Hybrid Materials, N.L. Hancox

Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-Bromopyruvate

PubMed Central

Chen, Zhao; Zhang, Hui; Lu, Weiqin; Huang, Peng

2009-01-01

Summary It has long been observed that cancer cells rely more on glycolysis to generate ATP and actively use certain glycolytic metabolic intermediates for biosynthesis. Hexokinase II (HKII) is a key glycolytic enzyme that plays a role in the regulation of the mitochondria-initiated apoptotic cell death. As a potent inhibitor of hexokinase, 3-bromopyruvate (3-BrPA) is known to inhibit cancer cell energy metabolism and trigger cell death, supposedly through depletion of cellular ATP. The current study showed that 3-BrPA caused a covalent modification of HKII protein and directly triggered its dissociation from mitochondria, leading to a specific release of apoptosis-inducing factor (AIF) from the mitochondria to cytosol and eventual cell death. Co-immunoprecipitation revealed a physical interaction between HKII and AIF. Using a competitive peptide of HKII, we showed that the dissociation of hexokinase II from mitochondria alone could cause apoptotic cell death, especially in the mitochondria-deficient ρ0 cells that highly express HKII. Interestingly, the dissociation of HKII itself did no directly affect the mitochondrial membrane potential, ROS generation, and oxidative phosphorylation. Our study suggests that the physical association between HKII and AIF is important for the normal localization of AIF in the mitochondria, and disruption of this protein complex by 3-BrPA leads to their release from the mitochondria and eventual cell death. PMID:19285479

Analogue of Caldera Dynamics: the Controlled Salt Cavern Collapse

NASA Astrophysics Data System (ADS)

Jousset, P. G.; Rohmer, J.

2012-12-01

Caldera collapse (or pit-crater) dynamics are inferred from geological observations and laboratory experiments. Here, we present an analogue of caldera collapse at field scale and possible analogy with large scale caldera dynamics. Through an original exploitation technique in sedimentary environment, a salt layer is emptied, leaving a brine-filled cavern, which eventually collapses after overburden falls into the cavern. Such a collapse was monitored in East France by many instruments (including GPS, extensometers, geophones, broadband seismological sensors, tiltmeter, gravity meter, … ), which allowed us to describe mechanisms of the collapse. Micro-seismicity is a good indicator of spatio-temporal evolution of physical properties of rocks prior to catastrophic events like volcanic eruptions or landslides and may be triggered by a number of causes including dynamic characteristics of processes in play or/and external forces. We show evidence of triggered micro-seismicity observed in the vicinity of this underground salt cavern prone to collapse by a remote M~7.2 earthquake, which occurred ~12000 kilometres away. High-dynamic broadband records reveal the strong time-correlation between a dramatic change in the rate of local high-frequency micro-seismicity and the passage of low-frequency seismic waves, including body, Love and Rayleigh surface waves. Pressure was lowered in the cavern by pumping operations of brine out of the cavern. We demonstrate the near critical state of the cavern before the collapse by means of 2D axisymmetric elastic finite-element simulations. Stress oscillations due to the seismic waves may have exceeded the strength required for the rupture of the complex media made of brine and rock triggering micro-earthquakes and leading to damage of the overburden and eventually collapse of the salt cavern. The increment of stress necessary for the failure of a Dolomite layer is of the same order or magnitude as the maximum dynamic stress magnitude observed during the passage of the earthquakes waves. On this basis, we discuss the possible contribution of the Love and Rayleigh low-frequency surfaces waves. This experiment may help us understand mechanisms of caldera formation.

Overly long centrioles and defective cell division upon excess of the SAS-4-related protein CPAP.

PubMed

Kohlmaier, Gregor; Loncarek, Jadranka; Meng, Xing; McEwen, Bruce F; Mogensen, Mette M; Spektor, Alexander; Dynlacht, Brian D; Khodjakov, Alexey; Gönczy, Pierre

2009-06-23

The centrosome is the principal microtubule organizing center (MTOC) of animal cells. Accurate centrosome duplication is fundamental for genome integrity and entails the formation of one procentriole next to each existing centriole, once per cell cycle. The procentriole then elongates to eventually reach the same size as the centriole. The mechanisms that govern elongation of the centriolar cylinder and their potential relevance for cell division are not known. Here, we show that the SAS-4-related protein CPAP is required for centrosome duplication in cycling human cells. Furthermore, we demonstrate that CPAP overexpression results in the formation of abnormally long centrioles. This also promotes formation of more than one procentriole in the vicinity of such overly long centrioles, eventually resulting in the presence of supernumerary MTOCs. This in turn leads to multipolar spindle assembly and cytokinesis defects. Overall, our findings suggest that centriole length must be carefully regulated to restrict procentriole number and thus ensure accurate cell division.

Information Dynamics and Aspects of Musical Perception

NASA Astrophysics Data System (ADS)

Dubnov, Shlomo

Musical experience has been often suggested to be related to forming of expectations, their fulfillment or denial. In terms of information theory, expectancies and predictions serve to reduce uncertainty about the future and might be used to efficiently represent and "compress" data. In this chapter we present an information theoretic model of musical listening based on the idea that expectations that arise from past musical material are framing our appraisal of what comes next, and that this process eventually results in creation of emotions or feelings. Using a notion of "information rate" we can measure the amount of information between past and present in the musical signal on different time scales using statistics of sound spectral features. Several musical pieces are analyzed in terms of short and long term information rate dynamics and are compared to analysis of musical form and its structural functions. The findings suggest that a relation exists between information dynamics and musical structure that eventually leads to creation of human listening experience and feelings such as "wow" and "aha".

DNA Damage Induced by Alkylating Agents and Repair Pathways

PubMed Central

Kondo, Natsuko; Takahashi, Akihisa; Ono, Koji; Ohnishi, Takeo

2010-01-01

The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes, necessitating a clear understanding of the repair mechanisms. Simple methylating agents form adducts at N- and O-atoms. N-methylations are removed by base excision repair, AlkB homologues, or nucleotide excision repair (NER). O6-methylguanine (MeG), which can eventually become cytotoxic and mutagenic, is repaired by O6-methylguanine-DNA methyltransferase, and O6MeG:T mispairs are recognized by the mismatch repair system (MMR). MMR cannot repair the O6MeG/T mispairs, which eventually lead to double-strand breaks. Bifunctional alkylating agents form interstrand cross-links (ICLs) which are more complex and highly cytotoxic. ICLs are repaired by complex of NER factors (e.g., endnuclease xeroderma pigmentosum complementation group F-excision repair cross-complementing rodent repair deficiency complementation group 1), Fanconi anemia repair, and homologous recombination. A detailed understanding of how cells cope with DNA damage caused by alkylating agents is therefore potentially useful in clinical medicine. PMID:21113301

Are CMEs capable of producing Moreton waves? A case study: the 2006 December 6 event

NASA Astrophysics Data System (ADS)

Krause, G.; Cécere, M.; Zurbriggen, E.; Costa, A.; Francile, C.; Elaskar, S.

2018-02-01

Considering the chromosphere and a stratified corona, we examine, by performing 2D compressible magnetohydrodynamics simulations, the capability of a coronal mass ejection (CME) scenario to drive a Moreton wave. We find that given a typical flux rope (FR) magnetic configuration, in initial pseudo-equilibrium, the larger the magnetic field and the lighter (and hotter) the FR, the larger the amplitude and the speed of the chromospheric disturbance, which eventually becomes a Moreton wave. We present arguments to explain why Moreton waves are much rarer than CME occurrences. In the frame of the present model, we explicitly exclude the action of flares that could be associated with the CME. Analysing the Mach number, we find that only fast magnetosonic shock waves will be able to produce Moreton events. In these cases an overexpansion of the FR is always present and it is the main factor responsible for the Moreton generation. Finally, we show that this scenario can account for the Moreton wave of the 2006 December 6 event (Francile et al. 2013).

Intermittent burst of a super rogue wave in the breathing multi-soliton regime of an anomalous fiber ring cavity.

PubMed

Lee, Seungjong; Park, Kyoungyoon; Kim, Hyuntai; Vazquez-Zuniga, Luis Alonso; Kim, Jinseob; Jeong, Yoonchan

2018-04-30

We report the intermittent burst of a super rogue wave in the multi-soliton (MS) regime of an anomalous-dispersion fiber ring cavity. We exploit the spatio-temporal measurement technique to log and capture the shot-to-shot wave dynamics of various pulse events in the cavity, and obtain the corresponding intensity probability density function, which eventually unveils the inherent nature of the extreme events encompassed therein. In the breathing MS regime, a specific MS regime with heavy soliton population, the natural probability of pulse interaction among solitons and dispersive waves exponentially increases owing to the extraordinarily high soliton population density. Combination of the probabilistically started soliton interactions and subsequently accompanying dispersive waves in their vicinity triggers an avalanche of extreme events with even higher intensities, culminating to a burst of a super rogue wave nearly ten times stronger than the average solitons observed in the cavity. Without any cavity modification or control, the process naturally and intermittently recurs within a time scale in the order of ten seconds.

Stellar Death by Black Hole: How Tidal Disruption Events Unveil the High Energy Universe

NASA Astrophysics Data System (ADS)

Coughlin, Eric Robert

2017-08-01

When a star comes very close to a supermassive black hole, the tidal field of the hole can be strong enough to deform and stretch the star into a stream of debris. Half of this stellar debris stream returns to the black hole and forms an accretion disk, briefly lighting up the black hole and, in the most extreme cases, launching relativistic jets. These ``tidal disruption events,'' from the initial stellar destruction to the eventual jet production, are the focus of my thesis, and during this talk I will describe some of the theoretical advances we have made in understanding them. I will also discuss more recent work that shows how this relatively simple picture can be more complicated when the disrupting black hole is part of a binary system. Despite the added complexity, I will argue that there is a timescale over which one expects to see variation in the luminosity of a tidal disruption event from a binary supermassive black hole system. Using these predictions and a set of simulations, I will motivate such an interpretation for the superluminous supernova ASASSN-15lh.

Geodetic Imaging and Tsunami Modeling of the 2017 Coupled Landslide-Tsunami Event in Karrat Fjord, West Greenland.

NASA Astrophysics Data System (ADS)

Barba, M.; Willis, M. J.; Tiampo, K. F.; Lynett, P. J.; Mätzler, E.; Thorsøe, K.; Higman, B. M.; Thompson, J. A.; Morin, P. J.

2017-12-01

We use a combination of geodetic imaging techniques and modelling efforts to examine the June 2017 Karrat Fjord, West Greenland, landslide and tsunami event. Our efforts include analysis of pre-cursor motions extracted from Sentinal SAR interferometry that we improved with high-resolution Digital Surface Models derived from commercial imagery and geo-coded Structure from Motion analyses. We produce well constrained estimates of landslide volume through DSM differencing by improving the ArcticDEM coverage of the region, and provide modeled tsunami run-up estimates at villages around the region, constrained with in-situ observations provided by the Greenlandic authorities. Estimates of run-up at unoccupied coasts are derived using a blend of high resolution imagery and elevation models. We further detail post-failure slope stability for areas of interest around the Karrat Fjord region. Warming trends in the region from model and satellite analysis are combined with optical imagery to ascertain whether the influence of melting permafrost and the formation of small springs on a slight bench on the mountainside that eventually failed can be used as indicators of future events.

Is the Gravitational-Wave Ringdown a Probe of the Event Horizon?

PubMed

Cardoso, Vitor; Franzin, Edgardo; Pani, Paolo

2016-04-29

It is commonly believed that the ringdown signal from a binary coalescence provides a conclusive proof for the formation of an event horizon after the merger. This expectation is based on the assumption that the ringdown waveform at intermediate times is dominated by the quasinormal modes of the final object. We point out that this assumption should be taken with great care, and that very compact objects with a light ring will display a similar ringdown stage, even when their quasinormal-mode spectrum is completely different from that of a black hole. In other words, universal ringdown waveforms indicate the presence of light rings, rather than of horizons. Only precision observations of the late-time ringdown signal, where the differences in the quasinormal-mode spectrum eventually show up, can be used to rule out exotic alternatives to black holes and to test quantum effects at the horizon scale.

Risky communication: pitfalls in counseling about risk, and how to avoid them.

PubMed

O'Doherty, K; Suthers, G K

2007-08-01

A genetic counselor is often faced with the difficult task of conveying a set of complex and highly abstract factors associated with the client's risk of developing a familial disorder. The client is faced with the even more difficult task of making significant health-related decisions about an event which may or may not eventuate. Although there is a large corpus of research on this topic, much of the knowledge on risk communication is difficult to apply in a practical context. In this paper we draw together some insights on risk communication and decision-making under conditions of uncertainty, and apply them directly to the problem of communicating familial cancer risk. In particular, we focus on the distinction between individual risk and observed frequencies of adverse events, various framing effects, and contextualizing risk communication. We draw attention to some of the potential pitfalls in counseling about risk and offer avenues for circumventing them.

Predicted and experienced affective responses to the outcome of the 2008 U.S. presidential election.

PubMed

Kitchens, Michael B; Corser, Grant C; Gohm, Carol L; VonWaldner, Kristen L; Foreman, Elizabeth L

2010-12-01

People typically have intense feelings about politics. Therefore, it was no surprise that the campaign and eventual election of Barack Obama were highly anticipated and emotionally charged events, making it and the emotion experienced afterward a useful situation in which to replicate prior research showing that people typically overestimate the intensity and duration of their future affective states. Consequently, it was expected that Obama supporters and McCain supporters might overestimate the intensity of their affective responses to the outcome of the election. Data showed that while McCain supporters underestimated how happy they would be following the election, Obama supporters accurately predicted how happy they would be following the election. These data provide descriptive information on the accuracy of people's predicted reactions to the 2008 U.S. presidential election. The findings are discussed in the context of the broad literature and this specific and unique event.

Perspective: Advanced particle imaging

DOE PAGES

Chandler, David W.; Houston, Paul L.; Parker, David H.

2017-05-26

This study discuss, the first ion imaging experiment demonstrating the capability of collecting an image of the photofragments from a unimolecular dissociation event and analyzing that image to obtain the three-dimensional velocity distribution of the fragments, the efficacy and breadth of application of the ion imaging technique have continued to improve and grow. With the addition of velocity mapping, ion/electron centroiding, and slice imaging techniques, the versatility and velocity resolution have been unmatched. Recent improvements in molecular beam, laser, sensor, and computer technology are allowing even more advanced particle imaging experiments, and eventually we can expect multi-mass imaging with co-variancemore » and full coincidence capability on a single shot basis with repetition rates in the kilohertz range. This progress should further enable “complete” experiments—the holy grail of molecular dynamics—where all quantum numbers of reactants and products of a bimolecular scattering event are fully determined and even under our control.« less

Acute Cerebellar Ataxia Induced by Nivolumab

PubMed Central

Kawamura, Reina; Nagata, Eiichiro; Mukai, Masako; Ohnuki, Yoichi; Matsuzaki, Tomohiko; Ohiwa, Kana; Nakagawa, Tomoki; Kohno, Mitsutomo; Masuda, Ryota; Iwazaki, Masayuki; Takizawa, Shunya

2017-01-01

A 54-year-old woman with adenocarcinoma of the lung and lymph node metastasis experienced nystagmus and cerebellar ataxia 2 weeks after initiating nivolumab therapy. An evaluation for several autoimmune-related antibodies and paraneoplastic syndrome yielded negative results. We eventually diagnosed the patient with nivolumab-induced acute cerebellar ataxia, after excluding other potential conditions. Her ataxic gait and nystagmus resolved shortly after intravenous steroid pulse therapy followed by the administration of decreasing doses of oral steroids. Nivolumab, an immune checkpoint inhibitor, is known to induce various neurological adverse events. However, this is the first report of acute cerebellar ataxia associated with nivolumab treatment. PMID:29249765

Research Issues in Genetic Testing of Adolescents for Obesity

PubMed Central

Segal, Mary E.; Sankar, Pamela; Reed, Danielle R.

2006-01-01

Obesity is often established in adolescence, and advances are being made in identifying its genetic underpinnings. We examine issues related to the eventual likelihood of genetic tests for obesity targeted to adolescents: family involvement; comprehension of the test’s meaning; how knowledge of genetic status may affect psychological adaptation; minors’ ability to control events; parental/child autonomy; ability to make informed medical decisions; self-esteem; unclear distinctions between early/late onset for this condition; and social stigmatization. The public health arena will be important in educating families about possible future genetic tests for obesity. PMID:15478685

KSC-2012-4418

NASA Image and Video Library

2012-08-14

CAPE CANAVERAL, Fla. -- National Space Club Florida Committee Chair Steve Griffin presents NASA Commercial Crew Program Manager Ed Mango with an eagle statue during the club's August luncheon at the Radisson Resort at the Port in Cape Canaveral, Fla. Mango was the event's guest speaker, discussing the innovative steps the agency is taking with industry partners to develop the next U.S. space transportation capability to and from low Earth orbit, which will eventually be available for use by the U.S. government and other commercial customers. To learn more about the Commercial Crew Program, visit www.nasa.gov/commercialcrew. Photo credit: Kim Shiflett

KSC-2012-4402

NASA Image and Video Library

2012-08-14

CAPE CANAVERAL, Fla. -- Florida's Lt. Gov. Jennifer Carroll, left, and NASA Commercial Crew Program Manager Ed Mango pose for a photo at the National Space Club Florida Committee's August luncheon at the Radisson Resort at the Port in Cape Canaveral, Fla. Mango was the event's guest speaker, discussing the innovative steps the agency is taking with industry partners to develop the next U.S. space transportation capability to and from low Earth orbit, which will eventually be available for use by the U.S. government and other commercial customers. To learn more about the Commercial Crew Program, visit www.nasa.gov/commercialcrew. Photo credit: Kim Shiflett

KSC-2012-4401

NASA Image and Video Library

2012-08-14

CAPE CANAVERAL, Fla. -- Florida's Lt. Gov. Jennifer Carroll, left, and NASA Commercial Crew Program Manager Ed Mango discuss the future of human spaceflight at the National Space Club Florida Committee's August luncheon at the Radisson Resort at the Port in Cape Canaveral, Fla. Mango was the event's guest speaker, discussing the innovative steps the agency is taking with industry partners to develop the next U.S. space transportation capability to and from low Earth orbit, which will eventually be available for use by the U.S. government and other commercial customers. To learn more about the Commercial Crew Program, visit www.nasa.gov/commercialcrew. Photo credit: Kim Shiflett

KSC-2012-4403

NASA Image and Video Library

2012-08-14

CAPE CANAVERAL, Fla. -- Florida's Lt. Gov. Jennifer Carroll, left, and NASA Commercial Crew Program Manager Ed Mango pose for a photo at the National Space Club Florida Committee's August luncheon at the Radisson Resort at the Port in Cape Canaveral, Fla. Mango was the event's guest speaker, discussing the innovative steps the agency is taking with industry partners to develop the next U.S. space transportation capability to and from low Earth orbit, which will eventually be available for use by the U.S. government and other commercial customers. To learn more about the Commercial Crew Program, visit www.nasa.gov/commercialcrew. Photo credit: Kim Shiflett

Application of powder metallurgy techniques for the development of non-toxic ammunition. Final CRADA report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lowden, R.; Kelly, R.

1997-05-30

The purpose of the Cooperative Research and Development Agreement (CRADA) between Martin Marietta Energy Systems, Inc., and Delta Frangible Ammunition (DFA), was to identify and evaluate composite materials for the development of small arms ammunition. Currently available small arms ammunition utilizes lead as the major component of the projectile. The introduction of lead into the environment by these projectiles when they are expended is a rapidly increasing environmental problem. At certain levels, lead is a toxic metal to the environment and a continual health and safety concern for firearm users as well as those who must conduct lead recovery operationsmore » from the environment. DFA is a leading supplier of high-density mixtures, which will be used to replace lead-based ammunition in specific applications. Current non-lead ammunition has several limitations that prevent it from replacing lead-based ammunition in many applications (such as applications that require ballistics, weapon recoil, and weapon function identical to that of lead-based ammunition). The purpose of the CRADA was to perform the research and development to identify cost-effective materials to be used in small arms ammunition that eventually will be used in commercially viable, environmentally conscious, non-lead, frangible and/or non-frangible, ammunition.« less

Geoarchaelogical documentation of a series of destructive events at Montegibbio Roman villa site

NASA Astrophysics Data System (ADS)

Borgatti, Lisa; Cervi, Federico; Corsini, Alessandro; Castagnetti, Cristina; Cremonini, Stefano; Guandalini, Francesca; Labate, Donato; Pellegrini, Maurizio; Ronchetti, Francesco

2010-05-01

The Italian territory is rich in archaeological heritage, located in hilly, plain or coastal areas. Frequently, it is possible to find only the remains of ancient cultures, villages and sparse houses dating back many centuries. Therefore, no other documentation but the remains themselves can give information about both the existence and the events that eventually determined the end of historical sites, caused either by abandonment or destruction. The causes that can determine the abandonment or the destruction can be various, and may be due to anthropic and/or natural causes, and only in very few cases documents or pictures of these events are preserved. Anthropic causes can be diverse: wrong design and/or building schemes of the structure or of the foundation, wars etc. Natural causes could be variuos as well, and can be related to the environmental context of the site. For example, in mountainous areas the main causes can be landslides, snow avalanches, soil creep affecting the foundations. In plain areas floods are the main process leading to the disruption of hamlets. Along the coast tsunamis are to be considered. Other natural causes could be earthquakes or climate changes. In the Emilian Apennines, near Sassuolo (Modena, Italy), a Roman villa dated from the I century B.C. to the VI century A.D. has been excavated along a gentle slope. The villa can be divided in four different buildings from successive periods. During the first period of life of the villa (I century B.C.-I century A.D.) a destructive event caused the abandonment of this building, whose walls and mosaic floors have been destroyed in a odd way. Which was the cause of this destruction? An earthquake, a human error in construction or a landslide? What makes this question even more interesting is the probable relation of this event with an ancient source (Pliny the Older, Naturalis Historia II, 199) who remembers how in the Modena area a "portentum terrarum" (earthquake) and the collision of two mountains destroyed buildings and properties. Historically, the Sassuolo hills are identified as the location of this event, where similar destructive events have been attested also later on, also in correlation with the presence of mud volcanoes nearby the area. The research is aimed at defining the causes that determined the destruction of the Roman villa located along the Montegibbio slope. The study was carried out with a multidisciplinary approach, integrating several experts, including archaeologists, geologists and engineers. At present, no document or picture referring the causes of the destruction have been found. Therefore, in order to draw some hypotheses on the nature of the events, the analysis of the deformation of the remains, of the foundation of the buildings and the reconstruction of the slope evolution have been carried out. The results obtained so far highlight the fact that integration of geological records and archaeological evidence is the key point to unravel the evolution of this historical site.

Performance Analysis of Different Backoff Algorithms for WBAN-Based Emerging Sensor Networks

PubMed Central

Khan, Pervez; Ullah, Niamat; Ali, Farman; Ullah, Sana; Hong, Youn-Sik; Lee, Ki-Young; Kim, Hoon

2017-01-01

The Carrier Sense Multiple Access with Collision Avoidance (CSMA/CA) procedure of IEEE 802.15.6 Medium Access Control (MAC) protocols for the Wireless Body Area Network (WBAN) use an Alternative Binary Exponential Backoff (ABEB) procedure. The backoff algorithm plays an important role to avoid collision in wireless networks. The Binary Exponential Backoff (BEB) algorithm used in different standards does not obtain the optimum performance due to enormous Contention Window (CW) gaps induced from packet collisions. Therefore, The IEEE 802.15.6 CSMA/CA has developed the ABEB procedure to avoid the large CW gaps upon each collision. However, the ABEB algorithm may lead to a high collision rate (as the CW size is incremented on every alternative collision) and poor utilization of the channel due to the gap between the subsequent CW. To minimize the gap between subsequent CW sizes, we adopted the Prioritized Fibonacci Backoff (PFB) procedure. This procedure leads to a smooth and gradual increase in the CW size, after each collision, which eventually decreases the waiting time, and the contending node can access the channel promptly with little delay; while ABEB leads to irregular and fluctuated CW values, which eventually increase collision and waiting time before a re-transmission attempt. We analytically approach this problem by employing a Markov chain to design the PFB scheme for the CSMA/CA procedure of the IEEE 80.15.6 standard. The performance of the PFB algorithm is compared against the ABEB function of WBAN CSMA/CA. The results show that the PFB procedure adopted for IEEE 802.15.6 CSMA/CA outperforms the ABEB procedure. PMID:28257112

The "perfect storm" in compensation: convergence of events leads to a greater need to review compensation strategies.

PubMed

Jones, Robert B

2004-01-01

The recent unprecedented convergence of significant strategic events in the compensation arena has created the need for ongoing and extensive compensation planning. This article reviews the events leading to this point, describes the implications of the results from a recent Aon study with WorldatWork, and suggests what employers can do to successfully navigate the "perfect storm" in compensation.

Processing circuitry for single channel radiation detector

NASA Technical Reports Server (NTRS)

Holland, Samuel D. (Inventor); Delaune, Paul B. (Inventor); Turner, Kathryn M. (Inventor)

2009-01-01

Processing circuitry is provided for a high voltage operated radiation detector. An event detector utilizes a comparator configured to produce an event signal based on a leading edge threshold value. A preferred event detector does not produce another event signal until a trailing edge threshold value is satisfied. The event signal can be utilized for counting the number of particle hits and also for controlling data collection operation for a peak detect circuit and timer. The leading edge threshold value is programmable such that it can be reprogrammed by a remote computer. A digital high voltage control is preferably operable to monitor and adjust high voltage for the detector.

Propagation of damage in the rat brain following sarin exposure: Differential progression of early processes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lazar, Shlomi; Egoz, Inbal; Brandeis, Rachel

Sarin is an irreversible organophosphate cholinesterase inhibitor and a highly toxic warfare agent. Following the overt, dose-dependent signs (e.g. tremor, hyper secretion, seizures, respiratory depression and eventually death), brain damage is often reported. The goal of the present study was to characterize the early histopathological and biochemical events leading to this damage. Rats were exposed to 1LD50 of sarin (80 μg/kg, i.m.). Brains were removed at 1, 2, 6, 24 and 48 h and processed for analysis. Results showed that TSPO (translocator protein) mRNA increased at 6 h post exposure while TSPO receptor density increased only at 24 h. Inmore » all brain regions tested, bax mRNA decreased 1 h post exposure followed by an increase 24 h later, with only minor increase in bcl2 mRNA. At this time point a decrease was seen in both anti-apoptotic protein Bcl2 and pro-apoptotic Bax, followed by a time and region specific increase in Bax. An immediate elevation in ERK1/2 activity with no change in JNK may indicate an endogenous “first response” mechanism used to attenuate the forthcoming apoptosis. The time dependent increase in the severity of brain damage included an early bi-phasic activation of astrocytes, a sharp decrease in intact neuronal cells, a time dependent reduction in MAP2 and up to 15% of apoptosis. Thus, neuronal death is mostly due to necrosis and severe astrocytosis. The data suggests that timing of possible treatments should be determined by early events following exposure. For example, the biphasic changes in astrocytes activity indicate a possible beneficial effects of delayed anti-inflammatory intervention. - Highlights: • The severity of brain damage post 1LD50 sarin exposure is time dependent. • Sarin induce differential progression of early processes in the rat brain. • Potential treatments should be timed according to early events following exposure. • The biphasic astrocytes activity suggests a delay in anti-inflammatory intervention.« less

Changes in water, nitrogen and carbon cycling in loblolly pine (Pinus taeda L.) during a mortality event

NASA Astrophysics Data System (ADS)

Renninger, H. J.; Hornslein, N.; Siegert, C. M.

2017-12-01

Depending on the type of disturbance, the mortality process of an individual tree may occur over an extended period leading to changes in tree and ecosystem functioning throughout this time period and before ultimate tree death is evident. Therefore, the goals of this research were to quantify physiological changes occurring in loblolly pine (Pinus taeda L.) during an extended mortality event. In July 2015, ten trees were girdled to simulate a Southern pine beetle disturbance and trees were monitored until their eventual mortality which occurred from Aug. to Dec. of 2016. Sapflow rates and litterfall were monitored throughout the mortality process and photosynthetic rates and leaf nitrogen concentrations were measured at the height of the 2016 growing season. Girdled pines had significantly higher sapflow compared with control pines in the first month following girdling, then sapflow did not differ significantly for the remainder of the 2015 growing season. From Dec. 2015 to Dec. 2016, control trees had about 25% higher sapflow compared with girdled pines, but both groups maintained a similar relationship between sapflow and soil moisture. Extensive litterfall occurred throughout the 2016 growing season and litter had 50% higher N concentration than the prior growing season. N concentration of fresh leaves collected in 2016 did not differ in girdled vs. control pines but control pines had 64% higher maximum Rubisco-limited carboxylation rates (Vcmax) and 68% higher electron transport-limited carboxylation rates (Jmax) compared to girdled pines. Control pines also had 66% higher foliage densities and 44% larger growth ring widths than girdled pines at the end of the 2016 growing season. Taken together, these results highlight the physiological changes that occur in pines undergoing mortality before needles completely discolor and drop. Compared with control pines, girdled pines exhibited greater changes in carbon and nitrogen compared with water use suggesting that sapflow per unit leaf area was increased to compensate for the losses in total leaf area. These data highlight the importance of physiological measurements taken throughout a mortality event to more accurately quantify the changes in ecosystem-scale water, nitrogen and carbon balance occurring during disturbance episodes.

Observations of Solar Energetic Protons: A Comparison Between Model, Balloon, and In Situ Observations

NASA Astrophysics Data System (ADS)

Halford, A.; Millan, R. M.; Hudson, M. K.; McGregor, S. L.; Kress, B. T.

2014-12-01

The Balloon Array for Radiation belt Relativistic Electron Losses (BARREL) was designed to observe X-rays from precipitating electrons in the Earth's atmosphere. During the second campaign in January 2014 Solar Energetic Proton (SEP) events were detected in the BARREL payloads as they produced atmospheric x-rays, γ-rays, and directly injected protons observed by the scintillator on the BARREL payloads. A total of 6 payloads were up during the event beginning 7 January with an X-class flare at 1832 UT, spread across a wide range of L and MLT. Payload 2I was on open field lines for the entire event while 2T (2W) crossed from open (closed) to closed (open) field lines over the course of the three day event. Payloads 2K and 2L were moving from the inner magnetosphere (L ~ 4) to higher field lines (L>6) while 2X stayed within the inner magnetosphere (L<6) for the entire event. Throughout this time, there were multiple conjunctions with the Van Allen Probes and good agreement with when (UT) and where (L-values) the energetic protons were observed, both in situ and at the balloons. In this poster we consider the transport of the protons from the sun and through the magnetosphere and eventual precipitation observed by the BARREL balloons.

Insulin, cognition, and dementia

PubMed Central

Cholerton, Brenna; Baker, Laura D.; Craft, Suzanne

2015-01-01

Cognitive disorders of aging represent a serious threat to the social and economic welfare of current society. It is now widely recognized that pathology related to such conditions, particularly Alzheimer’s disease, likely begins years or decades prior to the onset of clinical dementia symptoms. This revelation has led researchers to consider candidate mechanisms precipitating the cascade of neuropathological events that eventually lead to clinical Alzheimer’s disease. Insulin, a hormone with potent effects in the brain, has recently received a great deal of attention for its potential beneficial and protective role in cognitive function. Insulin resistance, which refers to the reduced sensitivity of target tissues to the favorable effects of insulin, is related to multiple chronic conditions known to impact cognition and increase dementia risk. With insulin resistance-associated conditions reaching epidemic proportions, the prevalence of Alzheimer’s disease and other cognitive disorders will continue to rise exponentially. Fortunately, these chronic insulin-related conditions are amenable to pharmacological intervention. As a result, novel therapeutic strategies that focus on increasing insulin sensitivity in the brain may be an important target for protecting or treating cognitive decline. The following review will highlight our current understanding of the role of insulin in brain, potential mechanisms underlying the link between insulin resistance and dementia, and current experimental therapeutic strategies aimed at improving cognitive function via modifying the brain’s insulin sensitivity. PMID:24070815

Simultaneously hermaphroditic shrimp use lipophilic cuticular hydrocarbons as contact sex pheromones.

PubMed

Zhang, Dong; Terschak, John A; Harley, Maggy A; Lin, Junda; Hardege, Jörg D

2011-04-20

Successful mating is essentially a consequence of making the right choices at the correct time. Animals use specific strategies to gain information about a potential mate, which is then applied to decision-making processes. Amongst the many informative signals, odor cues such as sex pheromones play important ecological roles in coordinating mating behavior, enabling mate and kin recognition, qualifying mate choice, and preventing gene exchange among individuals from different populations and species. Despite overwhelming behavioral evidence, the chemical identity of most cues used in aquatic organisms remains unknown and their impact and omnipresence have not been fully recognized. In many crustaceans, including lobsters and shrimps, reproduction happens through a cascade of events ranging from initial attraction to formation of a mating pair eventually leading to mating. We examined the hypothesis that contact pheromones on the female body surface of the hermaphroditic shrimp Lysmata boggessi are of lipophilic nature, and resemble insect cuticular hydrocarbon contact cues. Via chemical analyses and behavioural assays, we show that newly molted euhermaphrodite-phase shrimp contain a bouquet of odor compounds. Of these, (Z)-9-octadecenamide is the key odor with hexadecanamide and methyl linoleate enhancing the bioactivity of the pheromone blend. Our results show that in aquatic systems lipophilic, cuticular hydrocarbon contact sex pheromones exist; this raises questions on how hydrocarbon contact signals evolved and how widespread these are in the marine environment.

Peer-to-peer lending and bias in crowd decision-making

PubMed Central

Uparna, Jayaram; Karampourniotis, Panagiotis; Horvat, Emoke-Agnes; Szymanski, Boleslaw; Korniss, Gyorgy; Bakdash, Jonathan Z.; Uzzi, Brian

2018-01-01

Peer-to-peer lending is hypothesized to help equalize economic opportunities for the world’s poor. We empirically investigate the “flat-world” hypothesis, the idea that globalization eventually leads to economic equality, using crowdfinancing data for over 660,000 loans in 220 nations and territories made between 2005 and 2013. Contrary to the flat-world hypothesis, we find that peer-to-peer lending networks are moving away from flatness. Furthermore, decreasing flatness is strongly associated with multiple variables: relatively stable patterns in the difference in the per capita GDP between borrowing and lending nations, ongoing migration flows from borrowing to lending nations worldwide, and the existence of a tie as a historic colonial. Our regression analysis also indicates a spatial preference in lending for geographically proximal borrowers. To estimate the robustness for these patterns for future changes, we construct a network of borrower and lending nations based on the observed data. Then, to perturb the network, we stochastically simulate policy and event shocks (e.g., erecting walls) or regulatory shocks (e.g., Brexit). The simulations project a drift towards rather than away from flatness. However, levels of flatness persist only for randomly distributed shocks. By contrast, loss of the top borrowing nations produces more flatness, not less, indicating how the welfare of the overall system is tied to a few distinctive and critical country–pair relationships. PMID:29590131

RNA Encapsidation and Packaging in the Phleboviruses

PubMed Central

Hornak, Katherine E.; Lanchy, Jean-Marc; Lodmell, J. Stephen

2016-01-01

The Bunyaviridae represents the largest family of segmented RNA viruses, which infect a staggering diversity of plants, animals, and insects. Within the family Bunyaviridae, the Phlebovirus genus includes several important human and animal pathogens, including Rift Valley fever virus (RVFV), severe fever with thrombocytopenia syndrome virus (SFTSV), Uukuniemi virus (UUKV), and the sandfly fever viruses. The phleboviruses have small tripartite RNA genomes that encode a repertoire of 5–7 proteins. These few proteins accomplish the daunting task of recognizing and specifically packaging a tri-segment complement of viral genomic RNA in the midst of an abundance of host components. The critical nucleation events that eventually lead to virion production begin early on in the host cytoplasm as the first strands of nascent viral RNA (vRNA) are synthesized. The interaction between the vRNA and the viral nucleocapsid (N) protein effectively protects and masks the RNA from the host, and also forms the ribonucleoprotein (RNP) architecture that mediates downstream interactions and drives virion formation. Although the mechanism by which all three genomic counterparts are selectively co-packaged is not completely understood, we are beginning to understand the hierarchy of interactions that begins with N-RNA packaging and culminates in RNP packaging into new virus particles. In this review we focus on recent progress that highlights the molecular basis of RNA genome packaging in the phleboviruses. PMID:27428993

Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding

PubMed Central

Smirnov, Alexey; Zubrienė, Asta; Manakova, Elena; Gražulis, Saulius

2018-01-01

The structure-thermodynamics correlation analysis was performed for a series of fluorine- and chlorine-substituted benzenesulfonamide inhibitors binding to several human carbonic anhydrase (CA) isoforms. The total of 24 crystal structures of 16 inhibitors bound to isoforms CA I, CA II, CA XII, and CA XIII provided the structural information of selective recognition between a compound and CA isoform. The binding thermodynamics of all structures was determined by the analysis of binding-linked protonation events, yielding the intrinsic parameters, i.e., the enthalpy, entropy, and Gibbs energy of binding. Inhibitor binding was compared within structurally similar pairs that differ by para- or meta-substituents enabling to obtain the contributing energies of ligand fragments. The pairs were divided into two groups. First, similar binders—the pairs that keep the same orientation of the benzene ring exhibited classical hydrophobic effect, a less exothermic enthalpy and a more favorable entropy upon addition of the hydrophobic fragments. Second, dissimilar binders—the pairs of binders that demonstrated altered positions of the benzene rings exhibited the non-classical hydrophobic effect, a more favorable enthalpy and variable entropy contribution. A deeper understanding of the energies contributing to the protein-ligand recognition should lead toward the eventual goal of rational drug design where chemical structures of ligands could be designed based on the target protein structure. PMID:29503769

Reinforcement principles for addiction medicine; from recreational drug use to psychiatric disorder.

PubMed

Edwards, Scott

2016-01-01

The transition from recreational drug use to addiction can be conceptualized as a pathological timeline whereby the psychological mechanisms responsible for disordered drug use evolve from positive reinforcement to favor elements of negative reinforcement. Abused substances (ranging from alcohol to psychostimulants) are initially ingested at regular occasions according to their positive reinforcing properties. Importantly, repeated exposure to rewarding substances sets off a chain of secondary reinforcing events, whereby cues and contexts associated with drug use may themselves become reinforcing and thereby contribute to the continued use and possible abuse of the substance(s) of choice. Indeed, the powerful reinforcing efficacy of certain drugs may eclipse that of competing social rewards (such as career and family) and lead to an aberrant narrowing of behavioral repertoire. In certain vulnerable individuals, escalation of drug use over time is thought to drive specific molecular neuroadaptations that foster the development of addiction. Research has identified neurobiological elements of altered reinforcement following excessive drug use that comprise within-circuit and between-circuit neuroadaptations, both of which contribute to addiction. Central to this process is the eventual potentiation of negative reinforcement mechanisms that may represent the final definitive criterion locking vulnerable individuals into a persistent state of addiction. Targeting the neural substrates of reinforcement likely represents our best chances for therapeutic intervention for this devastating disease. © 2016 Elsevier B.V. All rights reserved.

Peer-to-peer lending and bias in crowd decision-making.

PubMed

Singh, Pramesh; Uparna, Jayaram; Karampourniotis, Panagiotis; Horvat, Emoke-Agnes; Szymanski, Boleslaw; Korniss, Gyorgy; Bakdash, Jonathan Z; Uzzi, Brian

2018-01-01

Peer-to-peer lending is hypothesized to help equalize economic opportunities for the world's poor. We empirically investigate the "flat-world" hypothesis, the idea that globalization eventually leads to economic equality, using crowdfinancing data for over 660,000 loans in 220 nations and territories made between 2005 and 2013. Contrary to the flat-world hypothesis, we find that peer-to-peer lending networks are moving away from flatness. Furthermore, decreasing flatness is strongly associated with multiple variables: relatively stable patterns in the difference in the per capita GDP between borrowing and lending nations, ongoing migration flows from borrowing to lending nations worldwide, and the existence of a tie as a historic colonial. Our regression analysis also indicates a spatial preference in lending for geographically proximal borrowers. To estimate the robustness for these patterns for future changes, we construct a network of borrower and lending nations based on the observed data. Then, to perturb the network, we stochastically simulate policy and event shocks (e.g., erecting walls) or regulatory shocks (e.g., Brexit). The simulations project a drift towards rather than away from flatness. However, levels of flatness persist only for randomly distributed shocks. By contrast, loss of the top borrowing nations produces more flatness, not less, indicating how the welfare of the overall system is tied to a few distinctive and critical country-pair relationships.

Chronic ibuprofen administration reduces neuropathic pain but does not exert neuroprotection after spinal cord injury in adult rats.

PubMed

Redondo-Castro, Elena; Navarro, Xavier

2014-02-01

Ibuprofen is commonly used as an anti-inflammatory analgesic drug, although it is not amongst the first-line treatments for neuropathic pain. Its main effects are mediated by non-specific inhibition of COX enzymes, but it also exerts some COX-independent effects, such as the inhibition of RhoA signaling and the modulation of glial activity. These effects have boosted the use of ibuprofen as a tool to promote axonal regeneration and to increase functional recovery after neural injuries, although with controversial results showing positive and negative outcomes of ibuprofen treatment in several experimental models. We have evaluated the effects of ibuprofen administered at 60 mg/kg twice a day to rats subjected to a mild spinal cord contusion. Our results indicate that ibuprofen ameliorates mechanical hyperalgesia in rats by reducing central hyperexcitability, but failed to produce improvements in the recovery of locomotion. Despite an early effect on reducing microglial reactivity, the ibuprofen treatment did not provide histological evidence of neuroprotection; indeed the volume of cord tissue spared rostral to the lesion was decreased in ibuprofen treated rats. In summary, the early modulation of neuroinflammation produced by the administration of ibuprofen seems to eventually lead to a worse resolution of detrimental events occurring in the secondary injury phase, but also to reduce the development of neuropathic pain. Copyright © 2013 Elsevier Inc. All rights reserved.

Rollover in volcanic crater lakes: a possible cause for Lake Nyos type disasters

NASA Astrophysics Data System (ADS)

Rice, A.

2000-04-01

Seemingly stably stratified fluids, that is a heavier layer of fluid underlying an upper layer of lighter fluid, can overturn if there is a heat flux through the system. Such events are termed ;rollover; in the engineering literature (occurring for instance in liquid natural gas tanks). They take place as well in lakes and ponds. In all such cases, the stratification starts off with the heavier, more dense fluid underlying lighter. Convection driven mixing at the stratification interface (due to the heat flux) as well as other processes serves to minimize with time the stabilizing density differences, which may eventually cause the stratification to invert. If gas has been contained under pressure in the lower layer, this gas may explosively vent from the fluid as it suddenly rises to the top such as occurs in liquid natural gas tanks where rollover is a hazard. These processes are quantifiable and are applied here to various scenarios that might refer to volcanic crater lakes whose lower layers are charged with volatiles. Provided herein are some examples of calculated conditions and calculated time of evolution leading to rollover with attendant release of gases from supersaturated ascending fluids. These calculations suggest rollover could occur in volcanic lakes. The August 1986 gas release at Lake Nyos is employed as an example. These estimates were made taking note that water is commonly supersaturated in CO2

Geodynamic processes and deformation in orogenic belts

NASA Astrophysics Data System (ADS)

Dennis, John G.; Jacoby, Wolfgang R.

1980-03-01

The development of geosynclines and orogenic belts is related to lithosphere convergence. Initial sediment accumulation implying subsidence, and volcanic activity implying extension and rise of geotherms, are in most cases followed by folding and thrusting suggesting compression and by uplift. In terms of recent analogs, sediment accumulation and crustal extension are characteristic of back-arc spreading; subsequent compression would indicate continent—continent collision; and rise of geotherms most likely requires localized thermal flow (convection) in the asthenosphere. These events are here shown to agree with Andrews and Sleep's (1974) numerical model of asthenosphere flow at converging plate margins. Orthogeosynclinal subsidence appears to be a consequence of subcrustal ablation and lithosphere extension and thinning in active marginal basins. Arc and Andean type magmatism mark the reappearance of ablated and transported, relatively low-density subcrustal material. Collision slows and eventually stops the local convection cell, resulting in local heat accumulation and hence high- T, low- P metamorphism and granitization while marginal basin (orthogeosynclinal) deposits are being compressed into Alpine style orogenic structures. Moreover, closing of the marginal basin leads to subsidiary subduction, which in turn may be responsible for some Alpine style structures. Oceanic trench deposits may become incorporated in orogenic zones, as high- P, low- T metamorphic belts (thalassogeosynclines). Dynamic uplift is a fundamental characteristic of orogeny. Most rising and sinking in orogenic zones can be linked to those asthenosphere processes which are a consequence of Andrews-Sleep convection.

Fasciola hepatica glycoconjugates immuneregulate dendritic cells through the Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin inducing T cell anergy

PubMed Central

Rodríguez, Ernesto; Kalay, Hakan; Noya, Verónica; Brossard, Natalie; Giacomini, Cecilia; van Kooyk, Yvette; García-Vallejo, Juan J.; Freire, Teresa

2017-01-01

Dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN) expressed on a variety of DCs, is a C-type lectin receptor that recognizes glycans on a diverse range of pathogens, including parasites. The interaction of DC-SIGN with pathogens triggers specific signaling events that modulate DC-maturation and activity and regulate T-cell activation by DCs. In this work we evaluate whether F. hepatica glycans can immune modulate DCs via DC-SIGN. We demonstrate that DC-SIGN interacts with F. hepatica glycoconjugates through mannose and fucose residues. We also show that mannose is present in high-mannose structures, hybrid and trimannosyl N-glycans with terminal GlcNAc. Furthermore, we demonstrate that F. hepatica glycans induce DC-SIGN triggering leading to a strong production of TLR-induced IL-10 and IL-27p28. In addition, parasite glycans induced regulatory DCs via DC-SIGN that decrease allogeneic T cell proliferation, via the induction of anergic/regulatory T cells, highlighting the role of DC-SIGN in the regulation of innate and adaptive immune responses by F. hepatica. Our data confirm the immunomodulatory properties of DC-SIGN triggered by pathogen-derived glycans and contribute to the identification of immunomodulatory glyans of helminths that might eventually be useful for the design of vaccines against fasciolosis. PMID:28436457

Fasciola hepatica glycoconjugates immuneregulate dendritic cells through the Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin inducing T cell anergy.

PubMed

Rodríguez, Ernesto; Kalay, Hakan; Noya, Verónica; Brossard, Natalie; Giacomini, Cecilia; van Kooyk, Yvette; García-Vallejo, Juan J; Freire, Teresa

2017-04-24

Dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN) expressed on a variety of DCs, is a C-type lectin receptor that recognizes glycans on a diverse range of pathogens, including parasites. The interaction of DC-SIGN with pathogens triggers specific signaling events that modulate DC-maturation and activity and regulate T-cell activation by DCs. In this work we evaluate whether F. hepatica glycans can immune modulate DCs via DC-SIGN. We demonstrate that DC-SIGN interacts with F. hepatica glycoconjugates through mannose and fucose residues. We also show that mannose is present in high-mannose structures, hybrid and trimannosyl N-glycans with terminal GlcNAc. Furthermore, we demonstrate that F. hepatica glycans induce DC-SIGN triggering leading to a strong production of TLR-induced IL-10 and IL-27p28. In addition, parasite glycans induced regulatory DCs via DC-SIGN that decrease allogeneic T cell proliferation, via the induction of anergic/regulatory T cells, highlighting the role of DC-SIGN in the regulation of innate and adaptive immune responses by F. hepatica. Our data confirm the immunomodulatory properties of DC-SIGN triggered by pathogen-derived glycans and contribute to the identification of immunomodulatory glyans of helminths that might eventually be useful for the design of vaccines against fasciolosis.

Acute-on-chronic liver failure: Pathogenesis, prognostic factors and management

PubMed Central

Blasco-Algora, Sara; Masegosa-Ataz, José; Gutiérrez-García, María Luisa; Alonso-López, Sonia; Fernández-Rodríguez, Conrado M

2015-01-01

Acute-on-chronic liver failure (ACLF) is increasingly recognized as a complex syndrome that is reversible in many cases. It is characterized by an acute deterioration of liver function in the background of a pre-existing chronic liver disease often associated with a high short-term mortality rate. Organ failure (OF) is always associated, and plays a key role in determining the course, and the outcome of the disease. The definition of ACLF remains controversial due to its overall ambiguity, with several disparate criteria among various associations dedicated to the study of liver diseases. Although the precise pathogenesis needs to be clarified, it appears that an altered host response to injury might be a contributing factor caused by immune dysfunction, ultimately leading to a pro-inflammatory status, and eventually to OF. The PIRO concept (Predisposition, Insult, Response and Organ Failure) has been proposed to better approach the underlying mechanisms. It is accepted that ACLF is a different and specific form of liver failure, where a precipitating event is always involved, even though it cannot always be ascertained. According to several studies, infections and active alcoholism often trigger ACLF. Viral hepatitis, gastrointestinal haemorrhage, or drug induced liver injury, which can also provoke the syndrome. This review mainly focuses on the physiopathology and prognostic aspects. We believe these features are essential to further understanding and providing the rationale for improveddisease management strategies. PMID:26576097

Inferior ST-Elevation Acute Myocardial Infarction or an Inferior-Lead Brugada-like Electrocardiogram Pattern Associated With the Use of Pregabalin and Quetiapine?

PubMed

Brunetti, Natale D; Ieva, Riccardo; Correale, Michele; Cuculo, Andrea; Santoro, Francesco; Guaricci, Andrea I; De Gennaro, Luisa; Gaglione, Antonio; Di Biase, Matteo

2016-01-01

The Brugada electrocardiogram pattern is characterized by coved-type ST-elevation (>2 mm) in the right precordial leads. We report the case of a 62-year-old man, with bipolar disorder, admitted to the emergency department because of dyspnea and chest discomfort. The patient was on treatment with pregabalin and quetiapine. Unexpectedly, electrocardiogram at admission showed diffuse ST-elevation, more evident in inferior leads, where a Brugada-like pattern was present. The patient underwent coronary angiography with a diagnosis of suspected acute coronary syndrome. Coronary angiography, however, showed mild coronary artery disease not requiring coronary angioplasty. Echocardiography did not reveal left ventricular dysfunction or pericardial effusion. Troponin levels remained normal over serial controls. Eventually, chest radiography showed lung opacities and consolidation suggestive for pneumonia. To the best of our knowledge, this is one of the first cases showing a transient Brugada-like electrocardiogram pattern in inferior leads, probably amplified by the administration of pregabalin and quetiapine.

Future climate risk from compound events

NASA Astrophysics Data System (ADS)

Zscheischler, Jakob; Westra, Seth; van den Hurk, Bart J. J. M.; Seneviratne, Sonia I.; Ward, Philip J.; Pitman, Andy; AghaKouchak, Amir; Bresch, David N.; Leonard, Michael; Wahl, Thomas; Zhang, Xuebin

2018-06-01

Floods, wildfires, heatwaves and droughts often result from a combination of interacting physical processes across multiple spatial and temporal scales. The combination of processes (climate drivers and hazards) leading to a significant impact is referred to as a `compound event'. Traditional risk assessment methods typically only consider one driver and/or hazard at a time, potentially leading to underestimation of risk, as the processes that cause extreme events often interact and are spatially and/or temporally dependent. Here we show how a better understanding of compound events may improve projections of potential high-impact events, and can provide a bridge between climate scientists, engineers, social scientists, impact modellers and decision-makers, who need to work closely together to understand these complex events.

A Study of a Classical Leader: Sun Tzu and His Influence on Mao Tse-Tung

DTIC Science & Technology

1986-04-01

lived. The primary source for this chapter is Dr. Samuel B. Griffith’s translation of the treatise from Sun Hsing- yen , a leading Chinese authority on Sun...Ch in, Wei, Han, Chao, Yen , and Yueh. The latter two states played no major parts in the wars which were to eventually unite China. Because all the...troops. 8. The nine variables: The nine variables of tactics are as follows: (.) You should not encamp in low-lying ground. (2.) In communicating

The Role of an Organized Exercise and Diet Program in the Primary Prevention of Ischemic Coronary Artery Disease in the U.S. Air Force Aviators

DTIC Science & Technology

1997-05-01

33.3% in 1988 and 25.4% in 1980."° This upward trend in obesity has been attributed to Americans leading a more sedentary lifestyle (i.e. lack of...has revealed several articles which link hypercholesterolemia and sedentary lifestyle epidemiologically to ischemic coronary artery disease.’ 49...and eventually can obstruct coronary arteries. Biological plausibility is therefore demonstrated by a high TC/HDL ratio and sedentary lifestyle hastening

Gene Expression and Structural Skeletal Responses to Long-Duration Simulated Microgravity in Rats

NASA Technical Reports Server (NTRS)

Shirazi-Fard, Yasaman; Rael, Victoria E.; Torres, Samantha; Steczina, Sonette; Bryant, Sheenah; Tahimic, Candice; Globus, Ruth K.

2017-01-01

In this study, we aim to examine skeletal responses to simulated long-duration spaceflight (90 days) and weight-bearing recovery on bone loss using the ground-based hindlimb unloading (HU) model in adolescent (3-month old) male rats. We hypothesized that simulated microgravity leads to the temporal regulation of oxidative defense genes and pro-bone resorption factors, where there is a progression and eventual plateau; furthermore, early transient changes in these pathways precede skeletal adaptations.

Transformation and Precipitation of Toxic Metals by Pseudomonas maltophilia

DTIC Science & Technology

1990-05-31

under investigation. This project could provide useful information toward the eventual exploitation of P . maltophilia and related organisms for the...Chromate . P CW1 I. SCUJ CLASWICATIN I | 5CUU1T CLAS31F ATON I. SCURFl’ CASSW CA1 .O- W MTA.nQN Of A&STIACT of REPQRT OP THIS PAGE 00 AASTRAC1...chromate (Cr04 or Cr(VI)), and lead (Pb(II)). Experimental progress to date is summarized below. (i) Reduction of selenite When P . maltophilia (strain OR-02

Jamaican Maritime Security. What are the Capability Gaps that Limit the Jamaica Defence Force in the Execution of its Roles in Maritime Security

DTIC Science & Technology

2017-06-09

revenue was generated from living resources such as fish, non-living resources such as oil, and ecosystems and ecosystem processes such as tourism ...however, based on the size of Jamaica’s tourism industry and other ocean economy related industries it is reasonable to conclude that it is a...and other marine resources eventually leads to damaged beaches and coastlines, and ultimately damages tourism and other industries. Though Jamaicans

Remote measurement utilizing NASA's scanning laser Doppler systems. Volume 2: Laser Doppler dust devil velocity profile measurement program

NASA Technical Reports Server (NTRS)

Howle, R. E.; Krause, M. C.; Craven, C. E.; Gorzynski, E. J.; Edwards, B. B.

1976-01-01

The first detailed velocity profile data on thermally induced dust vortices are presented. These dust devils will be analyzed and studied to determine their flow fields and origin in an effort to correlate this phenomena with the generation and characteristics of tornadoes. A continuing effort to increase mankind's knowledge of vortex and other meteorological phenomena will hopefully allow the prediction of tornado occurrence, their path, and perhaps eventually even lead to some technique for their destruction.

Paths of Adoption: Routes to Continuous Process Improvement

DTIC Science & Technology

2014-07-01

To obtain a process the team will use: The Team Lead has worked on teams with good processes and wants their new team to start out on the right foot ...eventually going to have to eat the entire process-improvement elephant . So, how do you get the “Never- Adopters” to undertake the effort? The key is to...Air Warfare Center Abstract. This paper covers the different types of teams the authors have en- countered as NAVAIR Internal Process Coaches and how

Modification of the actions of some neuroactive drugs by growth hormone

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tang, L.C.; Cotzias, G.C.

The flat serum growth hormone (GH) patterns of untreated parkinsonian patients develop diurnal rises during treatment with levodopa. This chronic exposure to excesses of GH might lead to the eventual emergence of the ''on-off'' phenomenon, which would indicate a need for animal experiments. Pretreatment of mice with GH increased (1) cerebral dopa and dopamine concentrations in levodopa-treated mice, (2) cerebral accumulation of injected tritiated apomorphine and tritiated thymidine, and (3) behavioral responses to levodopa, L-m-tyrosine, apomorphine hydrochloride, and oxotremorine. (auth)

Infantile Hepatic Hemangioendothelioma: An Uncommon Cause of Persistent Pulmonary Hypertension in a Newborn Infant.

PubMed

Chatmethakul, Trassanee; Bhat, Ramachandra; Alkaabi, Maryam; Siddiqui, Abdul; Peevy, Keith; Zayek, Michael

2016-07-01

Multifocal and diffuse infantile hepatic hemangioendotheliomas commonly present with signs of high-output congestive heart failure. In addition, prolonged persistent pulmonary overcirculation eventually leads to the development of pulmonary hypertension at a later age. We report a 2-day old, full-term infant with multifocal, large infantile hepatic hemangioendothelioma, who presented with an early onset of pulmonary hypertension, managed successfully with supportive care and systemic therapy directed toward the involution of infantile hepatic hemangioendothelioma.

Population mixture model for nonlinear telomere dynamics

NASA Astrophysics Data System (ADS)

Itzkovitz, Shalev; Shlush, Liran I.; Gluck, Dan; Skorecki, Karl

2008-12-01

Telomeres are DNA repeats protecting chromosomal ends which shorten with each cell division, eventually leading to cessation of cell growth. We present a population mixture model that predicts an exponential decrease in telomere length with time. We analytically solve the dynamics of the telomere length distribution. The model provides an excellent fit to available telomere data and accounts for the previously unexplained observation of telomere elongation following stress and bone marrow transplantation, thereby providing insight into the nature of the telomere clock.

Using the Lagrangian Method to Track Trajectories of Fog And Mist in the Monterey Bay

DTIC Science & Technology

2017-12-01

inversions (Koračin et al. 2014). During these extensive research experiments (Pilié et al. 1979) the role of the Eastern Pacific High was the...the inversion , which then lifts and eventually erodes the marine layer (Koračin et al. 2005). 22 Figure 13. Trajectories from a thermal low lead... inversion characteristics support fog and stratus conditions. Figure 20. Annotation of “L” for June 1, which classifies “Local” wind conditions

Early boost and slow consolidation in motor skill learning.

PubMed

Hotermans, Christophe; Peigneux, Philippe; Maertens de Noordhout, Alain; Moonen, Gustave; Maquet, Pierre

2006-01-01

Motorskill learning is a dynamic process that continues covertly after training has ended and eventually leads to delayed increments in performance. Current theories suggest that this off-line improvement takes time and appears only after several hours. Here we show an early transient and short-lived boost in performance, emerging as early as 5-30 min after training but no longer observed 4 h later. This early boost is predictive of the performance achieved 48 h later, suggesting its functional relevance for memory processes.

A Novel Cutaneous Fatty Acid–Binding Protein-Related Signaling Pathway Leading to Malignant Progression in Prostate Cancer Cells

PubMed Central

Bao, Zhengzheng; Malki, Mohammad I.; Forootan, Shiva S.; Adamson, Janet; Forootan, Farzad S.; Chen, Danqing; Foster, Christopher S.; Rudland, Philip S.

2013-01-01

Cutaneous fatty acid–binding protein (C-FABP), a cancer promoter and metastasis inducer, is overexpressed in the majority of prostatic carcinomas. Investigation of molecular mechanisms involved in tumor-promoting activity of C-FABP has established that there is a fatty acid–initiated signaling pathway leading to malignant progression of prostatic cancer cells. Increased C-FABP expression plays an important role in this novel signaling pathway. Thus, when C-FABP expression is increased, excessive amounts of fatty acids are transported into the nucleus where they act as signaling molecules to stimulate their nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ). The activated PPARγ then modulates the expression of its downstream target regulatory genes, which eventually lead to enhanced tumor expansion and aggressiveness caused by an overgrowth of cells with reduced apoptosis and an increased angiogenesis. PMID:24167657

Comparative hazard analysis of processes leading to remarkable flash floods (France, 1930-1999)

NASA Astrophysics Data System (ADS)

Boudou, M.; Lang, M.; Vinet, F.; Cœur, D.

2016-10-01

Flash flood events are responsible for large economic losses and lead to fatalities every year in France. This is especially the case in the Mediterranean and oversea territories/departments of France, characterized by extreme hydro-climatological features and with a large part of the population exposed to flood risks. The recurrence of remarkable flash flood events, associated with high hazard intensity, significant damage and socio-political consequences, therefore raises several issues for authorities and risk management policies. This study aims to improve our understanding of the hazard analysis process in the case of four remarkable flood events: March 1930, October 1940, January 1980 and November 1999. Firstly, we present the methodology used to define the remarkability score of a flood event. Then, to identify the factors leading to a remarkable flood event, we explore the main parameters of the hazard analysis process, such as the meteorological triggering conditions, the return period of the rainfall and peak discharge, as well as some additional factors (initial catchment state, flood chronology, cascade effects, etc.). The results contribute to understanding the complexity of the processes leading to flood hazard and highlight the importance for risk managers of taking additional factors into account.

On the dynamics of neutral mutations in a mathematical model for a homogeneous stem cell population.

PubMed

Traulsen, Arne; Lenaerts, Tom; Pacheco, Jorge M; Dingli, David

2013-02-01

The theory of the clonal origin of cancer states that a tumour arises from one cell that acquires mutation(s) leading to the malignant phenotype. It is the current belief that many of these mutations give a fitness advantage to the mutant population allowing it to expand, eventually leading to disease. However, mutations that lead to such a clonal expansion need not give a fitness advantage and may in fact be neutral--or almost neutral--with respect to fitness. Such mutant clones can be eliminated or expand stochastically, leading to a malignant phenotype (disease). Mutations in haematopoietic stem cells give rise to diseases such as chronic myeloid leukaemia (CML) and paroxysmal nocturnal haemoglobinuria (PNH). Although neutral drift often leads to clonal extinction, disease is still possible, and in this case, it has important implications both for the incidence of disease and for therapy, as it may be more difficult to eliminate neutral mutations with therapy. We illustrate the consequences of such dynamics, using CML and PNH as examples. These considerations have implications for many other tumours as well.

Sulfation in lead-acid batteries

NASA Astrophysics Data System (ADS)

Catherino, Henry A.; Feres, Fred F.; Trinidad, Francisco

Virtually, all military land vehicle systems use a lead-acid battery to initiate an engine start. The maintainability of these batteries and as a consequence, system readiness, has suffered from a lack of understanding of the reasons for battery failure. Often, the term most commonly heard for explaining the performance degradation of lead-acid batteries is the word, sulfation. Sulfation is a residual term that came into existence during the early days of lead-acid battery development. The usage is part of the legend that persists as a means for interpreting and justifying the eventual performance deterioration and failure of lead-acid batteries. The usage of this term is confined to the greater user community and, over time, has encouraged a myriad of remedies for solving sulfation problems. One can avoid the connotations associated with the all-inclusive word, sulfation by visualizing the general "sulfation" effect in terms of specific mechanistic models. Also, the mechanistic models are essential for properly understanding the operation and making proper use this battery system. It is evident that the better the model, the better the level of understanding.

Mood, food, and obesity.

PubMed

Singh, Minati

2014-01-01

Food is a potent natural reward and food intake is a complex process. Reward and gratification associated with food consumption leads to dopamine (DA) production, which in turn activates reward and pleasure centers in the brain. An individual will repeatedly eat a particular food to experience this positive feeling of gratification. This type of repetitive behavior of food intake leads to the activation of brain reward pathways that eventually overrides other signals of satiety and hunger. Thus, a gratification habit through a favorable food leads to overeating and morbid obesity. Overeating and obesity stems from many biological factors engaging both central and peripheral systems in a bi-directional manner involving mood and emotions. Emotional eating and altered mood can also lead to altered food choice and intake leading to overeating and obesity. Research findings from human and animal studies support a two-way link between three concepts, mood, food, and obesity. The focus of this article is to provide an overview of complex nature of food intake where various biological factors link mood, food intake, and brain signaling that engages both peripheral and central nervous system signaling pathways in a bi-directional manner in obesity.

Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus

PubMed Central

Tangvarasittichai, Surapon

2015-01-01

Oxidative stress is increased in metabolic syndrome and type 2 diabetes mellitus (T2DM) and this appears to underlie the development of cardiovascular disease, T2DM and diabetic complications. Increased oxidative stress appears to be a deleterious factor leading to insulin resistance, dyslipidemia, β-cell dysfunction, impaired glucose tolerance and ultimately leading to T2DM. Chronic oxidative stress, hyperglycemia and dyslipidemia are particularly dangerous for β-cells from lowest levels of antioxidant, have high oxidative energy requirements, decrease the gene expression of key β-cell genes and induce cell death. If β-cell functioning is impaired, it results in an under production of insulin, impairs glucose stimulated insulin secretion, fasting hyperglycemia and eventually the development of T2DM. PMID:25897356

Retaining customers in a managed care market. Hospitals must understand the connection between patient satisfaction, loyalty, retention, and revenue.

PubMed

Gemme, E M

1997-01-01

Traditionally, health care patients have been treated by health care professionals as people with needs rather than as customers with options. Although managed care has restricted patient choice, choice has not been eliminated. The premise of this article is that patients are primary health care consumers. Adopting such a premise and developing an active customer retention program can help health care organizations change their culture for the better, which may lead to higher customer retention levels and increased revenues. Customer retention programs based on service excellence that empower employees to provide excellent care can eventually lead to a larger market share for health care organizations trying to survive this era of intense competition.

Progress of a Cross-Correlation Based Optical Strain Measurement Technique for Detecting Radial Growth on a Rotating Disk

NASA Technical Reports Server (NTRS)

Clem, Michelle M.; Abdul-Aziz, Ali; Woike, Mark R.; Fralick, Gustave C.

2015-01-01

The modern turbine engine operates in a harsh environment at high speeds and is repeatedly exposed to combined high mechanical and thermal loads. The cumulative effects of these external forces lead to high stresses and strains on the engine components, such as the rotating turbine disks, which may eventually lead to a catastrophic failure if left undetected. The operating environment makes it difficult to use conventional strain gauges, therefore, non-contact strain measurement techniques is of interest to NASA and the turbine engine community. This presentation describes one such approach; the use of cross correlation analysis to measure strain experienced by the engine turbine disk with the goal of assessing potential faults and damage.

[Agonism and antagonism].

PubMed

Rey, Anne-Lise

2016-12-01

This essay considers dissensus as the starting point for the construction of a common epistemic space rather than as the acknowledgement of an irreducible disagreement. In the argumentative confrontation and disagreements, we do not want to identify a process which might lead to agreement through rational debate. The aim of this essay is rather to understand how dissensus leads to the constitution of plural communities. It discusses a certain number of texts of political philosophy (Habermas, Mouffe, etc.), where the notion of agreement is crucial to an analysis of argumentative confrontations. This essay uses the hypothesis to analyse the circulation of Leibniz's dynamics in his correspondence with De Volder. This perspective shows eventually that dissensus is not an obstacle but the basis on which multiple circulations of theories are possible.

Effects of Replication and Transcription on DNA Structure-Related Genetic Instability.

PubMed

Wang, Guliang; Vasquez, Karen M

2017-01-05

Many repetitive sequences in the human genome can adopt conformations that differ from the canonical B-DNA double helix (i.e., non-B DNA), and can impact important biological processes such as DNA replication, transcription, recombination, telomere maintenance, viral integration, transposome activation, DNA damage and repair. Thus, non-B DNA-forming sequences have been implicated in genetic instability and disease development. In this article, we discuss the interactions of non-B DNA with the replication and/or transcription machinery, particularly in disease states (e.g., tumors) that can lead to an abnormal cellular environment, and how such interactions may alter DNA replication and transcription, leading to potential conflicts at non-B DNA regions, and eventually result in genetic stability and human disease.

Effects of Replication and Transcription on DNA Structure-Related Genetic Instability

PubMed Central

Wang, Guliang; Vasquez, Karen M.

2017-01-01

Many repetitive sequences in the human genome can adopt conformations that differ from the canonical B-DNA double helix (i.e., non-B DNA), and can impact important biological processes such as DNA replication, transcription, recombination, telomere maintenance, viral integration, transposome activation, DNA damage and repair. Thus, non-B DNA-forming sequences have been implicated in genetic instability and disease development. In this article, we discuss the interactions of non-B DNA with the replication and/or transcription machinery, particularly in disease states (e.g., tumors) that can lead to an abnormal cellular environment, and how such interactions may alter DNA replication and transcription, leading to potential conflicts at non-B DNA regions, and eventually result in genetic stability and human disease. PMID:28067787

Bandgap engineering through nanocrystalline magnetic alloy grafting on reduced graphene oxide.

PubMed

De, D; Chakraborty, M; Majumdar, S; Giri, S

2014-09-28

High conductivity and the absence of ferromagnetism in pristine graphene fail to satisfy primary criteria for possible technological application in spintronics. Opening of the bandgap in graphene is primarily desirable for such applications. We report a simplified and novel approach of controlled grafting of a magnetic alloy on reduced graphene oxide. This eventually leads to ferromagnetism of the stable hybrid material at room temperature, with a large moment (∼1.2 μB) and a remarkable decrease in conductivity (∼10 times) compared to highly ordered pyrolytic graphite. Our model band-structure calculation indicates that the combined effect of controlled vacancies and impurities attributed to the nanocrystalline alloy grafting leads to a promising step toward band gap engineering.

A Multi-Objective Partition Method for Marine Sensor Networks Based on Degree of Event Correlation.

PubMed

Huang, Dongmei; Xu, Chenyixuan; Zhao, Danfeng; Song, Wei; He, Qi

2017-09-21

Existing marine sensor networks acquire data from sea areas that are geographically divided, and store the data independently in their affiliated sea area data centers. In the case of marine events across multiple sea areas, the current network structure needs to retrieve data from multiple data centers, and thus severely affects real-time decision making. In this study, in order to provide a fast data retrieval service for a marine sensor network, we use all the marine sensors as the vertices, establish the edge based on marine events, and abstract the marine sensor network as a graph. Then, we construct a multi-objective balanced partition method to partition the abstract graph into multiple regions and store them in the cloud computing platform. This method effectively increases the correlation of the sensors and decreases the retrieval cost. On this basis, an incremental optimization strategy is designed to dynamically optimize existing partitions when new sensors are added into the network. Experimental results show that the proposed method can achieve the optimal layout for distributed storage in the process of disaster data retrieval in the China Sea area, and effectively optimize the result of partitions when new buoys are deployed, which eventually will provide efficient data access service for marine events.

Electrochemical inactivation of cyanobacteria and microcystin degradation using a boron-doped diamond anode - A potential tool for cyanobacterial bloom control.

PubMed

Meglič, Andrej; Pecman, Anja; Rozina, Tinkara; Leštan, Domen; Sedmak, Bojan

2017-03-01

Cyanobacterial blooms are global phenomena that can occur in calm and nutrient-rich (eutrophic) fresh and marine waters. Human exposure to cyanobacteria and their biologically active products is possible during water sports and various water activities, or by ingestion of contaminated water. Although the vast majority of harmful cyanobacterial products are confined to the interior of the cells, these are eventually released into the surrounding water following natural or artificially induced cell death. Electrochemical oxidation has been used here to damage cyanobacteria to halt their proliferation, and for microcystin degradation under in-vitro conditions. Partially spent Jaworski growth medium with no addition of supporting electrolytes was used. Electrochemical treatment resulted in the cyanobacterial loss of cell-buoyancy regulation, cell proliferation arrest, and eventual cell death. Microcystin degradation was studied separately in two basic modes of treatment: batch-wise flow, and constant flow, for electrolytic-cell exposure. Batch-wise exposure simulates treatment under environmental conditions, while constant flow is more appropriate for the study of boron-doped diamond electrode efficacy under laboratory conditions. The effectiveness of microcystin degradation was established using high-performance liquid chromatography-photodiode array detector analysis, while the biological activities of the products were estimated using a colorimetric protein phosphatase-1 inhibition assay. The results indicate potential for the application of electro-oxidation methods for the control of bloom events by taking advantage of specific intrinsic ecological characteristics of bloom-forming cyanobacteria. The applicability of the use of boron-doped diamond electrodes in remediation of water exposed to cyanobacteria bloom events is discussed. Copyright © 2016. Published by Elsevier B.V.

Atmospheric blocking as a traffic jam in the jet stream

NASA Astrophysics Data System (ADS)

Nakamura, N.; Huang, S. Y.

2017-12-01

It is demonstrated using the ERA-Interim product that synoptic to intraseasonal variabilities of extratropical circulation in the boreal storm track regions are strongly affected by the zonal convergence of the column-integrated eastward flux of local wave activity (LWA). In particular, from the multi-year daily samples of LWA fluxes, we find that the wintertime zonal LWA flux in the jet exit regions tends to maximize for an intermediate value of column-averaged LWA. This is because an increasing LWA decelerates the zonal flow, eventually weakening the eastward advection of LWA. From theory we argue that large wave events on the decreasing side of the flux curve with increasing LWA cannot be maintained as a stable steady state. Consistent with this argument, observed states corresponding to that side of flux curve often exhibit local wave breaking and blocking events. A close parallelism exists for the traffic flow problem, in which the traffic flux (traffic density times traffic speed) is often observed to maximize for an intermediate value of traffic density. This is because the traffic speed is controlled not only by the imposed speed limit but also by the traffic density — an increasingly heavy traffic slows down the flow naturally and eventually decreases the flux. Once the flux starts to decrease with an increasing traffic density, a traffic jam kicks in suddenly (Lighthill and Whitham 1955, Richards 1956). The above idea is demonstrated by a simple conceptual model based on the equivalent barotropic PV contour design (Nakamura and Huang 2017, JAS), which predicts a threshold of blocking onset. The idea also suggests that the LWA that gives the `flux capacity,' i.e., the maximum LWA flux at a given location, is a useful predictor of local wave breaking/block formation.

An A-train climatology of extratropical cyclone clouds and precipitation

NASA Astrophysics Data System (ADS)

Naud, C. M.; Booth, J.; Del Genio, A. D.; van den Heever, S. C.; Posselt, D. J.

2016-12-01

It is demonstrated using the ERA-Interim product that synoptic to intraseasonal variabilities of extratropical circulation in the boreal storm track regions are strongly affected by the zonal convergence of the column-integrated eastward flux of local wave activity (LWA). In particular, from the multi-year daily samples of LWA fluxes, we find that the wintertime zonal LWA flux in the jet exit regions tends to maximize for an intermediate value of column-averaged LWA. This is because an increasing LWA decelerates the zonal flow, eventually weakening the eastward advection of LWA. From theory we argue that large wave events on the decreasing side of the flux curve with increasing LWA cannot be maintained as a stable steady state. Consistent with this argument, observed states corresponding to that side of flux curve often exhibit local wave breaking and blocking events. A close parallelism exists for the traffic flow problem, in which the traffic flux (traffic density times traffic speed) is often observed to maximize for an intermediate value of traffic density. This is because the traffic speed is controlled not only by the imposed speed limit but also by the traffic density — an increasingly heavy traffic slows down the flow naturally and eventually decreases the flux. Once the flux starts to decrease with an increasing traffic density, a traffic jam kicks in suddenly (Lighthill and Whitham 1955, Richards 1956). The above idea is demonstrated by a simple conceptual model based on the equivalent barotropic PV contour design (Nakamura and Huang 2017, JAS), which predicts a threshold of blocking onset. The idea also suggests that the LWA that gives the `flux capacity,' i.e., the maximum LWA flux at a given location, is a useful predictor of local wave breaking/block formation.

Feature analysis and primary causes of pre-flood season "cumulative effect" of torrential rain over South China

NASA Astrophysics Data System (ADS)

Chu, Qu-cheng; Wang, Qi-guang; Qiao, Shao-bo; Feng, Guo-lin

2018-01-01

When persistent rainfall occurs frequently over South China, meso-scale and micro-scale synoptic systems persist and expand in space and time and eventually form meso-scale and long-scale weather processes. The accumulation of multiple torrential rain processes is defined as a "cumulative effect" of torrential rain (CETR) event. In this paper, daily reanalysis datasets collected by the National Centers for Environmental Prediction-Department of Energy (NCEP-DOE) during 1979-2014 are used to study the anomalous features and causes of heavy CETR events over South China. The results show that there is a significant difference in the spatial distribution of the heavy CETR events. Based on the center position of the CETR, the middle region displayed middle-region-heavy CETR events while the western region displayed west-region-heavy CETR events. El Niño events in the previous period (December, January, February, March (DJFM)) are major extra-forcing factors of middle-region-heavy CETR events, which is beneficial for the continuous, anomalous Philippine Sea anticyclone and strengthens the West Pacific Subtropical High (WPSH), extending it more westward than normal. The primary water vapor source for precipitation in middle-region-heavy CETR events is the Tropical Western Pacific Ocean. The major extra-forcing factor of a west-region-heavy CETR is the negative anomaly in the southern Tropical Indian Ocean (TIO) during the previous period (DJFM). This factor is beneficial for strengthening the cross-equatorial flow and westerly winds from the Bay of Bengal to the South China Sea (SCS) and early SCS summer monsoon onset. The primary water vapor source of precipitation in the west-region-heavy CETR is the southern TIO.

Construction and Updating of Event Models in Auditory Event Processing

ERIC Educational Resources Information Center

Huff, Markus; Maurer, Annika E.; Brich, Irina; Pagenkopf, Anne; Wickelmaier, Florian; Papenmeier, Frank

2018-01-01

Humans segment the continuous stream of sensory information into distinct events at points of change. Between 2 events, humans perceive an event boundary. Present theories propose changes in the sensory information to trigger updating processes of the present event model. Increased encoding effort finally leads to a memory benefit at event…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Behroozi, Peter S.; Wechsler, Risa H.; Lu, Yu

We find that infalling dark matter halos (i.e., the progenitors of satellite halos) begin losing mass well outside the virial radius of their eventual host halos. The peak mass occurs at a range of clustercentric distances, with median and 68th percentile range ofmore » $$1.8^{+2.3}_{-1.0} \\,R_\\mathrm{vir,host}$$ for progenitors of z = 0 satellites. The peak circular velocity for infalling halos occurs at significantly larger distances ($$3.7^{+3.3}_{-2.2} \\,R_\\mathrm{vir,host}$$ at z = 0). This difference arises because different physical processes set peak circular velocity (typically, ~1:5 and larger mergers which cause transient circular velocity spikes) and peak mass (typically, smooth accretion) for infalling halos. We find that infalling halos also stop having significant mergers well before they enter the virial radius of their eventual hosts. Mergers larger than a 1:40 ratio in halo mass end for infalling halos at similar clustercentric distances (~1.9 R vir, host) as the end of overall mass accretion. However, mergers larger than 1:3 typically end for infalling halos at more than four virial radial away from their eventual hosts. This limits the ability of mergers to affect quenching and morphology changes in clusters. We also note that the transient spikes which set peak circular velocity may lead to issues with abundance matching on that parameter, including unphysical galaxy stellar mass growth profiles near clusters; we propose a simple observational test to check if a better halo proxy for galaxy stellar mass exists.« less

Revisiting salt marsh resilience to sea level rise: Are ponds responsible for permanent land loss?

NASA Astrophysics Data System (ADS)

Mariotti, G.

2016-12-01

Ponds are un-vegetated rounded depressions commonly present on marsh platforms. The role of ponds on the long-term morphological evolution of tidal marshes is unclear - at times ponds expand but eventually recover the marsh platform, at other times ponds never recover and lead to permanent marsh loss. Existing field observations indicate that episodic disturbances of the marsh vegetation cause the formation of small (1-10 m) isolated ponds, even if the vegetated platform keeps pace with Relative Sea Level Rise (RSLR), and that isolated ponds tend to deepen and enlarge until they eventually connect to the channel network. Here I implement a simple model to study the vertical and planform evolution of a single connected pond. A newly connected pond recovers if its bed lies above the limit for marsh plant growth, or if the inorganic deposition rate is larger than the RSLR rate. A pond that cannot accrete faster than RSLR will deepen and enlarge, eventually entering a runaway erosion by wave edge retreat. A large tidal range, a large sediment supply, and a low rate of RSLR favor pond recovery. The model suggests that inorganic sediment deposition alone controls pond recovery, even in marshes where organic matter dominates accretion of the vegetated platform. As such, halting permanent marsh loss by pond collapse requires to increase inorganic sediment deposition. Because pond collapse is possible even if the vegetated platform keeps pace with RSLR, I conclude that marsh resilience to RSLR is less than previously quantified.

An empirical study of the nuclear explosion-induced lightning seen on IVY-MIKE

NASA Astrophysics Data System (ADS)

Colvin, J. D.; Mitchell, C. K.; Greig, J. R.; Murphy, D. P.; Pechacek, R. E.; Raleigh, M.

1987-05-01

We report the results of a unique study of the lightninglike phenomena that were seen to accompany the MIKE shot of operation IVY on October 31 1952. MIKE was a thermonuclear surface burst yielding 10.4 MT, which took place on Enewetak Atoll. During the period of approximately 10 ms after detonation, five discrete luminous channels were seen to start from the ground or sea surface at a distance of approximately 1 km from the burst point and to grow up into the clouds. We have reexamined the original photographic records of IVY-MIKE, obtaining effective brightnesses (optical powers per unit length) for the luminous channels at different altitudes as functions of time. The absolute calibration for the MIKE records was deduced by comparison with the photographic records of other events of that era, laboratory measurements of film sensitivity, and use of atmospheric transmission data taken just prior to the MIKE event. Errors in this analysis lead to an uncertainty of a factor of ˜2 in the brightnesses of the luminous channels. In the laboratory we have used laser-guided electric discharges to create long (100 cm), arclike plasma channels to simulate the observed luminous channels and to allow determination of an empirical relation between the brightness of the channel and the electric current flowing in the channel. These laboratory discharges had peak currents up to 100 kA and periods of ˜2 ms. Spectroscopic analysis showed that the luminous channels consisted primarily of normal air plasma with typical ground-level contaminants. Photographic studies showed that these long-duration discharges are unstable to the m = 1 magnetohydrodynamic (MHD) instability and become severely distorted in less than 1 ms. By direct comparison of the luminous channels seen at MIKE and the laboratory discharges, we deduce: (1) the peak current in the prominent (brightest) channel at MIKE was between 200 and 600 kA. Here the most likely value of the peak current was 250±50 kA, but potential systematic errors in the film calibration and the comparison of MIKE and laboratory data make higher currents possible. (2) The rapid decline in the brightness of the luminous channels seen at MIKE is caused by a combination of the effects of the MHD instability, which eventually leads to a broadening of the current-carrying channel, and channel cooling by turbulent convective mixing.

Sustainable Land Management's potential for climate change adaptation in Mediterranean environments: a regional scale assessment

NASA Astrophysics Data System (ADS)

Eekhout, Joris P. C.; de Vente, Joris

2017-04-01

Climate change has strong implications for many essential ecosystem services, such as provision of drinking and irrigation water, soil erosion and flood control. Especially large impacts are expected in the Mediterranean, already characterised by frequent floods and droughts. The projected higher frequency of extreme weather events under climate change will lead to an increase of plant water stress, reservoir inflow and sediment yield. Sustainable Land Management (SLM) practices are increasingly promoted as climate change adaptation strategy and to increase resilience against extreme events. However, there is surprisingly little known about their impacts and trade-offs on ecosystem services at regional scales. The aim of this research is to provide insight in the potential of SLM for climate change adaptation, focusing on catchment-scale impacts on soil and water resources. We applied a spatially distributed hydrological model (SPHY), coupled with an erosion model (MUSLE) to the Segura River catchment (15,978 km2) in SE Spain. We run the model for three periods: one reference (1981-2000) and two future scenarios (2031-2050 and 2081-2100). Climate input data for the future scenarios were based on output from 9 Regional Climate Models and for different emission scenarios (RCP 4.5 and RCP 8.5). Realistic scenarios of SLM practices were developed based on a local stakeholder consultation process. The evaluated SLM scenarios focussed on reduced tillage and organic amendments under tree and cereal crops, covering 24% and 15% of the catchment, respectively. In the reference scenario, implementation of SLM at the field-scale led to an increase of the infiltration capacity of the soil and a reduction of surface runoff up to 29%, eventually reducing catchment-scale reservoir inflow by 6%. This led to a reduction of field-scale sediment yield of more than 50% and a reduced catchment-scale sediment flux to reservoirs of 5%. SLM was able to fully mitigate the effect of climate change at the field-scale and partly at the catchment-scale. Therefore, we conclude that large-scale adoption of SLM can effectively contribute to climate change adaptation by increasing the soil infiltration capacity, the soil water retention capacity and soil moisture content in the rootzone, leading to less crop stress. These findings of regional scale impacts of SLM are of high relevance for land-owners, -managers and policy makers to design effective climate change adaptation strategies.

Event Segmentation Improves Event Memory up to One Month Later

ERIC Educational Resources Information Center

Flores, Shaney; Bailey, Heather R.; Eisenberg, Michelle L.; Zacks, Jeffrey M.

2017-01-01

When people observe everyday activity, they spontaneously parse it into discrete meaningful events. Individuals who segment activity in a more normative fashion show better subsequent memory for the events. If segmenting events effectively leads to better memory, does asking people to attend to segmentation improve subsequent memory? To answer…

Comparison of Outcomes of antibiotic Drugs and Appendectomy (CODA) trial: a protocol for the pragmatic randomised study of appendicitis treatment

PubMed Central

Davidson, Giana H; Flum, David R; Talan, David A; Kessler, Larry G; Lavallee, Danielle C; Bizzell, Bonnie J; Farjah, Farhood; Stewart, Skye D; Krishnadasan, Anusha; Carney, Erin E; Wolff, Erika M; Comstock, Bryan A; Monsell, Sarah E; Heagerty, Patrick J; Ehlers, Annie P; DeUgarte, Daniel A; Kaji, Amy H; Evans, Heather L; Yu, Julianna T; Mandell, Katherine A; Doten, Ian C; Clive, Kevin S; McGrane, Karen M; Tudor, Brandon C; Foster, Careen S; Saltzman, Darin J; Thirlby, Richard C; Lange, Erin O; Sabbatini, Amber K; Moran, Gregory J

2017-01-01

Introduction Several European studies suggest that some patients with appendicitis can be treated safely with antibiotics. A portion of patients eventually undergo appendectomy within a year, with 10%–15% failing to respond in the initial period and a similar additional proportion with suspected recurrent episodes requiring appendectomy. Nearly all patients with appendicitis in the USA are still treated with surgery. A rigorous comparative effectiveness trial in the USA that is sufficiently large and pragmatic to incorporate usual variations in care and measures the patient experience is needed to determine whether antibiotics are as good as appendectomy. Objectives The Comparing Outcomes of Antibiotic Drugs and Appendectomy (CODA) trial for acute appendicitis aims to determine whether the antibiotic treatment strategy is non-inferior to appendectomy. Methods/Analysis CODA is a randomised, pragmatic non-inferiority trial that aims to recruit 1552 English-speaking and Spanish-speaking adults with imaging-confirmed appendicitis. Participants are randomised to appendectomy or 10 days of antibiotics (including an option for complete outpatient therapy). A total of 500 patients who decline randomisation but consent to follow-up will be included in a parallel observational cohort. The primary analytic outcome is quality of life (measured by the EuroQol five dimension index) at 4 weeks. Clinical adverse events, rate of eventual appendectomy, decisional regret, return to work/school, work productivity and healthcare utilisation will be compared. Planned exploratory analyses will identify subpopulations that may have a differential risk of eventual appendectomy in the antibiotic treatment arm. Ethics and dissemination This trial was approved by the University of Washington’s Human Subjects Division. Results from this trial will be presented in international conferences and published in peer-reviewed journals. Trial registration number NCT02800785. PMID:29146633

Lead arthritis and lead poisoning following bullet wounds: a clinicopathologic, ultrastructural, and microanalytic study of two cases.

PubMed

Slavin, R E; Swedo, J; Cartwright, J; Viegas, S; Custer, E M

1988-02-01

Bullet wounds causing lead synovitis in the wrist and knee are reported in two patients, one of whom also developed clinical plumbism. Very high lead levels in the synovial fluid are believed to be responsible for toxicity changes that occurred in the synovium and bone. Ultrastructurally, these alterations included the formation of nuclear lead inclusions, dilation, and degranulation of the rough endoplasmic reticulum and deposition of crystalline precipitates in the matrix of the mitochondria in macrophages, osteoclasts, and synoviocytes, as well as the development of cytoplasmic lead inclusions in osteoclasts. Energy-dispersive x-ray elemental analysis (EDXEA) indicated that the nuclear inclusions contained only lead, whereas precipitates within the mitochondria and elsewhere in the cytoplasm were composed of complexes containing lead, calcium, and phosphorus. Similarly constituted extracellular complexes were incorporated into newly formed trabecular bone laid down as a physiologic response to the bullet lodged within the wrist bones. This bone subsequently exhibited defects in bone resorption, which were characterized by depressed osteoclastic function and a unique lesion termed incomplete osteocytic osteolysis. The genesis of this latter lesion is uncertain. The sequestration of the partially degraded bone fragments containing lead complexes into the marrow and eventually into the joint spaces and synovium permitted the recycling of bone lead, and this may have played an important role in inducing clinical plumbism in one of the patients in this study.

Analysis of Effects of Sensor Multithreading to Generate Local System Event Timelines

DTIC Science & Technology

2014-03-27

works on logs highlights the importance of logs [17, 18]. The two aforementioned works both reference the same 2009 Data Breach Investigations Report...the data breaches report on, the logs contained evidence of events leading up to 82% of those data breaches . This means that preventing 82% of the data ...report states that of the data breaches reported on, the logs contained evidence of events leading up to 66% of those data breaches . • The 2010 DBIR

KSC-2012-4399

NASA Image and Video Library

2012-08-14

CAPE CANAVERAL, Fla. -- National Space Club Florida Committee Chair Steve Griffin, left, Florida's Lt. Gov. Jennifer Carroll, and NASA Commercial Crew Program Manager Ed Mango pose for a photo at the club's August luncheon at the Radisson Resort at the Port in Cape Canaveral, Fla. Mango was the event's guest speaker, discussing the innovative steps the agency is taking with industry partners to develop the next U.S. space transportation capability to and from low Earth orbit, which will eventually be available for use by the U.S. government and other commercial customers. To learn more about the Commercial Crew Program, visit www.nasa.gov/commercialcrew. Photo credit: Kim Shiflett

Challenge To Apollo: The Soviet Union and The Space Race, 1945-1974

NASA Technical Reports Server (NTRS)

Siddiqi, Asif A.

2000-01-01

This book is, in essence, sixteen years in the making. First attempted to compile a history of the Soviet space program in 1982 author put together a rough chronology of the main events. A decade later, while living on a couch in a college friend's apartment, he began writing what would be a short history of the Soviet lunar landing program. The first draft was sixty-nine pages long. Late the following year, he decided to expand the topic to handle all early Soviet piloted exploration programs. That work eventually grew into what you are holding in your hand now.

KSC-2012-4406

NASA Image and Video Library

2012-08-14

CAPE CANAVERAL, Fla. -- NASA Commercial Crew Program Manager Ed Mango, right, shows Florida's Lt. Gov. Jennifer Carroll the program's "Same Crew, New Ride" poster at the National Space Club Florida Committee's August luncheon at the Radisson Resort at the Port in Cape Canaveral, Fla. Mango was the event's guest speaker, discussing the innovative steps the agency is taking with industry partners to develop the next U.S. space transportation capability to and from low Earth orbit, which will eventually be available for use by the U.S. government and other commercial customers. To learn more about the Commercial Crew Program, visit www.nasa.gov/commercialcrew. Photo credit: Kim Shiflett

DOE Office of Scientific and Technical Information (OSTI.GOV)

Madison, Alison L.

As they say, membership has its privileges. Starbucks Gold members get coffee discounts. Costco members get to spend at least $100 per trip no matter what they went for. And loyalists of certain local businesses get first dibs on boat race tickets that actually involve shade. Here’s a new one for you. Members of the EB-5 Visa Program get legal residency--and eventually citizenship--in the U.S. When I first heard about it, I poignantly thought to myself, "Say what?" But I am now enlightened, and admittedly a tad enthusiastic, thanks to a couple of presenters at a recent Tri-Cities Research Districtmore » Speaker Series event.« less

Life on Mars - How it disappeared (if it was ever there)

NASA Technical Reports Server (NTRS)

Friedmann, E. Imre; Koriem, Ali M.

1989-01-01

Information available on Mars chemistry suggest that conditions on early Mars may have been suitable for life. This paper examines the possible events that led to the disappearance of life, assuming it existed, from the surface of Mars. The sequence of events leading to life extinction on early Mars assumes the following steps: (1) a decrease of temperature and humidity levels, leading to a selection of microorganisms for tolerance of low temperatures and arid conditions; (2) further deterioration of environment leading to withdrawal of cold-adapted organisms to protected niches under the surface; (3) further cooling producing heavy stresses in these organisms; and (4) further deterioration of the environment resulting in extinction. This sequence of events is considered parallel events documented for the microbial community in the Ross Desert of Antarctica, where TEM examinations of the material detected progressive stages of cell damage and death.

Fear of driving license withdrawal in patients with insulin-treated diabetes mellitus negatively influences their decision to report severe hypoglycemic events to physicians.

PubMed

Brož, Jan; Brabec, Marek; Janíčková Žďárská, Denisa; Fedáková, Zuzana; Hoskovcová, Lucie; You, Jee Young; Doničová, Viera; Hlaďo, Petr; Rahelić, Dario; Kvapil, Milan; Polák, Jan

2015-01-01

Under current European Union legislation, two severe hypoglycemic events within 12 months is grounds for driving license withdrawal. The aim of the study reported here was to determine whether fear of such a withdrawal could lead to patients concealing severe hypoglycemia from physicians, which could negatively impact further treatment decisions. A total of 663 patients with insulin-treated diabetes were anonymously surveyed about whether they would conceal severe hypoglycemic events from their physicians, if revealing them could result in driving license withdrawal. This investigation utilized an adapted and expanded questionnaire by Graveling et al. Of all diabetic patients surveyed, 26.17% would most likely not report hypoglycemia, and 25.86% were undecided. In a group of patients with type 1 diabetes, 31.83% would likely not report hypoglycemic events, and 25.06% were undecided. The patients least likely to report severe hypoglycemic events were those who indicated that vehicles were partly essential for work, and who also had more than two hypoglycemic events monthly. A considerable percentage of diabetic patients would likely conceal severe hypoglycemic events from their physicians due to fear of driving license withdrawal. Patient failure to report severe hypoglycemic events can potentially lead to physicians being misinformed regarding the patient's condition, which could lead to inadequate monitoring and treatment.

Discharge and suspended sediment patterns in a small mountainous watershed with widely distributed rock fragments

NASA Astrophysics Data System (ADS)

Fang, N. F.; Shi, Z. H.; Chen, F. X.; Zhang, H. Y.; Wang, Y. X.

2015-09-01

Understanding and quantifying sediment loads is important in watersheds with highly erodible materials, which will eventually cause environmental and ecological problems. Within this context, suspended sediment (SS) transport and its temporal dynamics were studied in a small mountainous watershed with sloping lands containing rock fragments in subtropical China. Soils containing rock fragments with many macro-pores have a high permeability rate. Over a 7-year period, the mean runoff coefficient of this watershed was 0.65. Overall, 30 flood events were monitored and accounted for 95.5%, 27.3%, 17.1% of the total SS load, precipitation and total discharge, respectively, over a 5-year period. The presence of rock fragments in soils can affect soil loss. When comparing the soil loss in the studied watershed with that of other watersheds under similar climatic conditions, rock fragments negatively affect soil loss. However, an extreme event occurred on 14 August 1990, and the sediment load exhibited a phenomenon called "small deposits towards lump withdrawal", which resulted in a soil loss of 20,499 t (4.6 times the mean yearly soil loss). This event exhausted most of the SSs stored by the rock fragments on the slope and channel. Following this event, the mean SS concentration (SSC) of the 11 events was 1.05 kg m-3, and the mean SSC of the 18 previous events was 1.75 kg m-3. Twelve variables were separated using the classical hydrograph separation method. Partial least-squares regression (PLSR) was used to determine the highly co-related variables of the discharge. The results indicated that PLSR could explain runoff well. The relationship between discharge and SSC was highly scattered. During 24 flood events, three types of hysteresis loops were observed: clockwise (17 events), figure-eight (3 events), and complex (4 events).

Tolerability of sibutramine during a 6-week treatment period in high-risk patients with cardiovascular disease and/or diabetes: a preliminary analysis of the Sibutramine Cardiovascular Outcomes (SCOUT) Trial.

PubMed

Maggioni, Aldo P; Caterson, Ian; Coutinho, Walmir; Finer, Nick; Gaal, Luc Van; Sharma, Arya M; Torp-Pedersen, Christian; Bacher, Peter; Shepherd, Gillian; Sun, Rui; James, Philip

2008-11-01

Uncertainties about the cardiovascular safety of sibutramine led to the SCOUT trial that is investigating sibutramine plus weight management in high-risk, overweight/obese patients. A 6-week lead-in period during which all patients received sibutramine permitted an initial assessment of tolerability. A total of 10,742 patients received sibutramine and 3.1% of these discontinued due to an adverse event; issues affecting more than 10 patients were drug intolerance, headache, insomnia, nausea, dry mouth, and constipation-, tachycardia-, and hypertension-related events. Serious adverse events, most commonly associated with the System Organ Class, Cardiac disorders, were reported by 2.7% of patients; however, the majority was not considered sibutramine-related. Adverse events relating to high blood pressure and/or pulse rate, whether reported as adverse events leading to discontinuation, or serious adverse events were reported by less than 0.2% of patients. No serious or individual events leading to discontinuation occurred in more than 25 patients. There were 15 (0.1%) deaths; 10 were attributed to a cardiovascular cause. Discontinuations for adverse events were lower than anticipated. Serious adverse events generally reflected sibutramine's known pharmacology or were related to cardiac disorders already present in this high-risk population. When compared with epidemiological data, overall mortality rate was low and sibutramine was well tolerated in this mainly off-label population. No new safety issues were detected.

Event-driven charge-coupled device design and applications therefor

NASA Technical Reports Server (NTRS)

Doty, John P. (Inventor); Ricker, Jr., George R. (Inventor); Burke, Barry E. (Inventor); Prigozhin, Gregory Y. (Inventor)

2005-01-01

An event-driven X-ray CCD imager device uses a floating-gate amplifier or other non-destructive readout device to non-destructively sense a charge level in a charge packet associated with a pixel. The output of the floating-gate amplifier is used to identify each pixel that has a charge level above a predetermined threshold. If the charge level is above a predetermined threshold the charge in the triggering charge packet and in the charge packets from neighboring pixels need to be measured accurately. A charge delay register is included in the event-driven X-ray CCD imager device to enable recovery of the charge packets from neighboring pixels for accurate measurement. When a charge packet reaches the end of the charge delay register, control logic either dumps the charge packet, or steers the charge packet to a charge FIFO to preserve it if the charge packet is determined to be a packet that needs accurate measurement. A floating-diffusion amplifier or other low-noise output stage device, which converts charge level to a voltage level with high precision, provides final measurement of the charge packets. The voltage level is eventually digitized by a high linearity ADC.

Slip triggered on southern California faults by the 1992 Joshua Tree, Landers, and big bear earthquakes

USGS Publications Warehouse

Bodin, Paul; Bilham, Roger; Behr, Jeff; Gomberg, Joan; Hudnut, Kenneth W.

1994-01-01

Five out of six functioning creepmeters on southern California faults recorded slip triggered at the time of some or all of the three largest events of the 1992 Landers earthquake sequence. Digital creep data indicate that dextral slip was triggered within 1 min of each mainshock and that maximum slip velocities occurred 2 to 3 min later. The duration of triggered slip events ranged from a few hours to several weeks. We note that triggered slip occurs commonly on faults that exhibit fault creep. To account for the observation that slip can be triggered repeatedly on a fault, we propose that the amplitude of triggered slip may be proportional to the depth of slip in the creep event and to the available near-surface tectonic strain that would otherwise eventually be released as fault creep. We advance the notion that seismic surface waves, perhaps amplified by sediments, generate transient local conditions that favor the release of tectonic strain to varying depths. Synthetic strain seismograms are presented that suggest increased pore pressure during periods of fault-normal contraction may be responsible for triggered slip, since maximum dextral shear strain transients correspond to times of maximum fault-normal contraction.

Medical Error Disclosure and Patient Safety: Legal Aspects

PubMed Central

Guillod, Olivier

2013-01-01

Reducing the number of preventable adverse events has become a public health issue. The paper discusses in which ways the law can contribute to that goal, especially by encouraging a culture of safety among healthcare professionals. It assesses the need or the usefulness to pass so-called disclosure laws and apology laws, to adopt mandatory but strictly confidential Critical Incidents Reporting Systems in hospitals, to change the fault-based system of medical liability or to amend the rules on criminal liability. The paper eventually calls for adding the law to the present agenda of patient safety. Significance for public health The extent of preventable adverse events and the correlative need to improve patient safety are recognized today as a public health issue. In order to lower the toll associated with preventable adverse events, the former culture of professionalism (based on the premise that a good physician doesn’t make mistakes) must be replaced by a culture of safety, which requires a multi-pronged approach that includes all the main stakeholders within the healthcare system. A number of legal reforms could help in prompting such a change. This contribution stresses the need to include legal aspects when trying to find appropriate responses to public health issues. PMID:25170502

The Water Cycle, a Potential Source of the Bacterial Pathogen Bacillus cereus.

PubMed

Brillard, Julien; Dupont, Christian M S; Berge, Odile; Dargaignaratz, Claire; Oriol-Gagnier, Stéphanie; Doussan, Claude; Broussolle, Véronique; Gillon, Marina; Clavel, Thierry; Bérard, Annette

2015-01-01

The behaviour of the sporulating soil-dwelling Bacillus cereus sensu lato (B. cereus sl) which includes foodborne pathogenic strains has been extensively studied in relation to its various animal hosts. The aim of this environmental study was to investigate the water compartments (rain and soil water, as well as groundwater) closely linked to the primary B. cereus sl reservoir, for which available data are limited. B. cereus sl was present, primarily as spores, in all of the tested compartments of an agricultural site, including water from rain to groundwater through soil. During rain events, leachates collected after transfer through the soil eventually reached the groundwater and were loaded with B. cereus sl. In groundwater samples, newly introduced spores of a B. cereus model strain were able to germinate, and vegetative cells arising from this event were detected for up to 50 days. This first B. cereus sl investigation in the various types of interrelated environments suggests that the consideration of the aquatic compartment linked to soil and to climatic events should provide a better understanding of B. cereus sl ecology and thus be relevant for a more accurate risk assessment of food poisoning caused by B. cereus sl pathogenic strains.

Formulating a subgrid-scale breakup model for microbubble generation from interfacial collisions

NASA Astrophysics Data System (ADS)

Chan, Wai Hong Ronald; Mirjalili, Shahab; Urzay, Javier; Mani, Ali; Moin, Parviz

2017-11-01

Multiphase flows often involve impact events that engender important effects like the generation of a myriad of tiny bubbles that are subsequently transported in large liquid bodies. These impact events are created by large-scale phenomena like breaking waves on ocean surfaces, and often involve the relative approach of liquid surfaces. This relative motion generates continuously shrinking length scales as the entrapped gas layer thins and eventually breaks up into microbubbles. The treatment of this disparity in length scales is computationally challenging. In this presentation, a framework is presented that addresses a subgrid-scale (SGS) model aimed at capturing the process of microbubble generation. This work sets up the components in an overarching volume-of-fluid (VoF) toolset and investigates the analytical foundations of an SGS model for describing the breakup of a thin air film trapped between two approaching water bodies in a physical regime corresponding to Mesler entrainment. Constituents of the SGS model, such as the identification of impact events and the accurate computation of the local characteristic curvature in a VoF-based architecture, and the treatment of the air layer breakup, are discussed and illustrated in simplified scenarios. Supported by Office of Naval Research (ONR)/A*STAR (Singapore).

The Water Cycle, a Potential Source of the Bacterial Pathogen Bacillus cereus

PubMed Central

Brillard, Julien; Dupont, Christian M. S.; Berge, Odile; Dargaignaratz, Claire; Oriol-Gagnier, Stéphanie; Doussan, Claude; Broussolle, Véronique; Gillon, Marina; Clavel, Thierry; Bérard, Annette

2015-01-01

The behaviour of the sporulating soil-dwelling Bacillus cereus sensu lato (B. cereus sl) which includes foodborne pathogenic strains has been extensively studied in relation to its various animal hosts. The aim of this environmental study was to investigate the water compartments (rain and soil water, as well as groundwater) closely linked to the primary B. cereus sl reservoir, for which available data are limited. B. cereus sl was present, primarily as spores, in all of the tested compartments of an agricultural site, including water from rain to groundwater through soil. During rain events, leachates collected after transfer through the soil eventually reached the groundwater and were loaded with B. cereus sl. In groundwater samples, newly introduced spores of a B. cereus model strain were able to germinate, and vegetative cells arising from this event were detected for up to 50 days. This first B. cereus sl investigation in the various types of interrelated environments suggests that the consideration of the aquatic compartment linked to soil and to climatic events should provide a better understanding of B. cereus sl ecology and thus be relevant for a more accurate risk assessment of food poisoning caused by B. cereus sl pathogenic strains. PMID:25918712

[Influence of new technologies in modern microbiology].

PubMed

Pumarola, Tomás

2010-10-01

The influence of new technologies in modern microbiology is directly related to their automation, the real driving force of change. Automation has occurred since the beginning of clinical microbiology, but from the 1980s has experienced huge development, which is being projected through the immediate future to all areas of the speciality. Automation has become a prime organizational tool. However, its main disadvantage is that it has no limits, which in association with the current economicallyoriented criteria, is encouraging initiatives to integrate the various laboratory specialities into one production center and, eventually, to outsource its activity. This process could significantly reduce the quality of clinical microbiology and the training of future specialists, or even worst, lead to the eventual disappearance of the speciality, at least as it is known today. The future development of highly automated and integrated laboratories is an irreversible process. To preserve the quality of the speciality and of specialist training, rather than fight directly against this process, we must, as microbiologists, actively participate with creativity and leadership. Copyright © 2010 Elsevier España S.L. All rights reserved.